KR20230133986A - 에스테르-연결된 아세탈을 포함하는 나노물질 - Google Patents
에스테르-연결된 아세탈을 포함하는 나노물질 Download PDFInfo
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- KR20230133986A KR20230133986A KR1020237023906A KR20237023906A KR20230133986A KR 20230133986 A KR20230133986 A KR 20230133986A KR 1020237023906 A KR1020237023906 A KR 1020237023906A KR 20237023906 A KR20237023906 A KR 20237023906A KR 20230133986 A KR20230133986 A KR 20230133986A
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
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- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
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- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
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| US12569438B2 (en) | 2019-07-29 | 2026-03-10 | Georgia Tech Research Corporation | Nanomaterials containing constrained lipids and uses thereof |
| US12435035B2 (en) | 2020-01-09 | 2025-10-07 | Guide Therapeutics, Llc | Nanomaterials |
| CN116782913A (zh) * | 2020-12-21 | 2023-09-19 | 比姆医疗股份有限公司 | 包括缩醛的纳米材料 |
| IL303845A (en) | 2021-01-20 | 2023-08-01 | Beam Therapeutics Inc | Nanomaterials include a degradable property |
| KR20230131863A (ko) | 2021-01-20 | 2023-09-14 | 빔 테라퓨틱스, 인크. | 나노물질 |
| EP4182295A1 (en) * | 2021-05-06 | 2023-05-24 | Stemirna Therapeutics Co., Ltd. | A lipid |
| TW202328067A (zh) | 2021-09-14 | 2023-07-16 | 美商雷納嘉德醫療管理公司 | 環狀脂質及其使用方法 |
| CN118317944A (zh) * | 2021-09-14 | 2024-07-09 | 雷纳嘉德医疗管理公司 | 非环状脂质及其使用方法 |
| EP4430024A1 (en) | 2021-11-08 | 2024-09-18 | Orna Therapeutics, Inc. | Lipid nanoparticle compositions for delivering circular polynucleotides |
| EP4452925A1 (en) * | 2021-12-20 | 2024-10-30 | Beam Therapeutics Inc. | Nanomaterial comprising diamines |
| WO2023122752A1 (en) | 2021-12-23 | 2023-06-29 | Renagade Therapeutics Management Inc. | Constrained lipids and methods of use thereof |
| TW202330457A (zh) * | 2022-01-19 | 2023-08-01 | 大陸商蘇州艾博生物科技有限公司 | 脂質化合物和脂質奈米顆粒組合物 |
| WO2024019936A1 (en) | 2022-07-20 | 2024-01-25 | Beam Therapeutics Inc. | Nanomaterials comprising triols |
| WO2024102972A1 (en) | 2022-11-11 | 2024-05-16 | Beam Therapeutics Inc. | Base editing of transthyretin gene |
| WO2024112775A1 (en) * | 2022-11-25 | 2024-05-30 | Beam Therapeutics Inc. | Compositions and methods for editing a transthyretin gene |
| WO2024138115A1 (en) | 2022-12-23 | 2024-06-27 | Intellia Theraperutics, Inc. | Systems and methods for genomic editing |
| CN118108613B (zh) * | 2022-12-26 | 2025-05-06 | 北京新合睿恩生物医疗科技有限公司 | 一种阳离子脂质化合物及制备方法和应用、mRNA递送系统 |
| WO2024192291A1 (en) * | 2023-03-15 | 2024-09-19 | Renagade Therapeutics Management Inc. | Delivery of gene editing systems and methods of use thereof |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025000542A1 (en) * | 2023-06-30 | 2025-01-02 | Shanghai Vitalgen Biopharma Co., Ltd. | Ionizable cationic lipid compounds for delivery of biologically active agents |
| CN121532376A (zh) * | 2023-07-19 | 2026-02-13 | 正基基因科技有限公司 | 脂质和脂质纳米颗粒 |
| WO2025038855A1 (en) * | 2023-08-16 | 2025-02-20 | Beam Therapeutics Inc. | Ionizable lipids with branched head groups |
| WO2025159966A1 (en) * | 2024-01-23 | 2025-07-31 | Beam Therapeutics Inc. | Compositions and methods for altering a nucleobase in a transthyretin polynucleotide |
| WO2025212851A2 (en) | 2024-04-03 | 2025-10-09 | Orbital Therapeutics, Inc. | mRNA COMPOSITIONS AND USES THEREOF IN VARICELLA ZOSTER VIRUS VACCINES |
| WO2025259931A1 (en) | 2024-06-14 | 2025-12-18 | Orbital Therapeutics, Inc. | Compositions and methods for rna circularization |
| WO2026006203A2 (en) | 2024-06-24 | 2026-01-02 | Orbital Therapeutics, Inc. | Compositions and methods for making circular rna |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
| WO2026006687A1 (en) | 2024-06-28 | 2026-01-02 | Orbital Therapeutics, Inc. | Circular rna compositions and uses thereof for diseases caused by varicella-zoster virus |
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| GB2075970B (en) * | 1980-04-10 | 1984-05-02 | Nippon Paint Co Ltd | Polymerisable amino acid compounds and their production |
| US20030083272A1 (en) | 1997-09-19 | 2003-05-01 | Lahive & Cockfield, Llp | Sense mrna therapy |
| DE19940641A1 (de) * | 1999-08-26 | 2001-03-01 | Basf Ag | Verfahren zur Herstellung von 4-Acyl-aminosäureestern und N-Acyl-Aminoacetalen |
| AU2009238175C1 (en) | 2008-04-15 | 2023-11-30 | Arbutus Biopharma Corporation | Novel lipid formulations for nucleic acid delivery |
| EP4286012A3 (en) | 2015-09-17 | 2024-05-29 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| JP2020514321A (ja) * | 2017-02-01 | 2020-05-21 | モデルナティーエックス, インコーポレイテッド | 活性化がん遺伝子変異ペプチドをコードする免疫調節治療mRNA組成物 |
| WO2020072605A1 (en) * | 2018-10-02 | 2020-04-09 | Intellia Therapeutics, Inc. | Ionizable amine lipids |
| WO2020219876A1 (en) * | 2019-04-25 | 2020-10-29 | Intellia Therapeutics, Inc. | Ionizable amine lipids and lipid nanoparticles |
| US12435035B2 (en) * | 2020-01-09 | 2025-10-07 | Guide Therapeutics, Llc | Nanomaterials |
| AU2021269137A1 (en) * | 2020-05-08 | 2022-12-15 | Orna Therapeutics, Inc. | Circular RNA compositions and methods |
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| EP4262819A1 (en) | 2023-10-25 |
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| AU2021410666A1 (en) | 2023-06-29 |
| IL303365A (en) | 2023-08-01 |
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| EP4262819A4 (en) | 2024-12-04 |
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