KR20230074719A - T 세포 제조 조성물 및 방법 - Google Patents

T 세포 제조 조성물 및 방법 Download PDF

Info

Publication number
KR20230074719A
KR20230074719A KR1020237008593A KR20237008593A KR20230074719A KR 20230074719 A KR20230074719 A KR 20230074719A KR 1020237008593 A KR1020237008593 A KR 1020237008593A KR 20237008593 A KR20237008593 A KR 20237008593A KR 20230074719 A KR20230074719 A KR 20230074719A
Authority
KR
South Korea
Prior art keywords
cells
antigen
cell
culture medium
peptide antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020237008593A
Other languages
English (en)
Korean (ko)
Inventor
비크람 주네자
제러드 디에체
브랜든 콘
재원 최
Original Assignee
바이오엔테크 유에스 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 바이오엔테크 유에스 인크. filed Critical 바이오엔테크 유에스 인크.
Publication of KR20230074719A publication Critical patent/KR20230074719A/ko
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K39/4611
    • A61K39/4622
    • A61K39/464464
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24Antigen-presenting cells [APC]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/34Antigenic peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4201Neoantigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4244Enzymes
    • A61K40/4253GTPases, e.g. Ras or Rho
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1121Dendritic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Moulding By Coating Moulds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Casting Or Compression Moulding Of Plastics Or The Like (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020237008593A 2020-08-13 2021-08-12 T 세포 제조 조성물 및 방법 Pending KR20230074719A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063065327P 2020-08-13 2020-08-13
US63/065,327 2020-08-13
PCT/US2021/045800 WO2022036137A1 (en) 2020-08-13 2021-08-12 T cell manufacturing compositions and methods

Publications (1)

Publication Number Publication Date
KR20230074719A true KR20230074719A (ko) 2023-05-31

Family

ID=80248187

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237008593A Pending KR20230074719A (ko) 2020-08-13 2021-08-12 T 세포 제조 조성물 및 방법

Country Status (14)

Country Link
US (1) US20230374455A1 (https=)
EP (1) EP4196135A4 (https=)
JP (1) JP2023539056A (https=)
KR (1) KR20230074719A (https=)
CN (1) CN116710551A (https=)
AU (1) AU2021325081A1 (https=)
BR (1) BR112023002733A2 (https=)
CA (1) CA3189285A1 (https=)
CL (1) CL2023000437A1 (https=)
CO (1) CO2023002953A2 (https=)
CU (1) CU20230011A7 (https=)
IL (1) IL300564A (https=)
MX (1) MX2023001815A (https=)
WO (1) WO2022036137A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3081840A1 (en) 2017-11-08 2019-05-16 Neon Therapeutics, Inc. T cell manufacturing compositions and methods
WO2023159088A1 (en) * 2022-02-15 2023-08-24 Marker Therapeutics, Inc. Compositions and methods for antigen-specific t cell expansion
CA3254900A1 (en) * 2022-03-30 2023-10-05 Mdx Management Llc COMPOSITIONS AND METHODS FOR ACTIVATING IMMUNE CELLS
CN121548636A (zh) * 2023-06-19 2026-02-17 北京沙砾生物医药股份有限公司 一种肿瘤特异性细胞的富集方法和应用
WO2025245492A1 (en) * 2024-05-24 2025-11-27 Biontech Us Inc. Compositions and methods for t cell manufacturing and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022788D0 (en) 1990-10-19 1990-12-05 Cortecs Ltd Pharmaceutical formulations
AU4998993A (en) 1992-08-07 1994-03-03 Epimmune, Inc. Hla binding peptides and their uses
CN1118572A (zh) 1993-03-05 1996-03-13 萨依特尔有限公司 Hla-a2.1组合肽及其用途
US5849589A (en) 1996-03-11 1998-12-15 Duke University Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
BR112012029066A2 (pt) 2010-05-14 2020-09-01 The General Hospital Corporation composições e processos de identificação de neoantígenos específicos de tumor.
EP3082853A2 (en) 2013-12-20 2016-10-26 The Broad Institute, Inc. Combination therapy with neoantigen vaccine
EP3446119A1 (en) 2016-04-18 2019-02-27 The Broad Institute Inc. Improved hla epitope prediction
CA3081840A1 (en) * 2017-11-08 2019-05-16 Neon Therapeutics, Inc. T cell manufacturing compositions and methods
WO2020047449A2 (en) * 2018-08-31 2020-03-05 Novartis Ag Methods of making chimeric antigen receptor-expressing cells
TWI777160B (zh) * 2019-05-08 2022-09-11 美商百歐恩泰美國公司 T細胞製備組合物及方法

Also Published As

Publication number Publication date
BR112023002733A2 (pt) 2023-05-02
EP4196135A1 (en) 2023-06-21
EP4196135A4 (en) 2024-08-21
CN116710551A (zh) 2023-09-05
MX2023001815A (es) 2023-04-11
CL2023000437A1 (es) 2023-07-28
JP2023539056A (ja) 2023-09-13
CA3189285A1 (en) 2022-02-17
IL300564A (en) 2023-04-01
CO2023002953A2 (es) 2023-05-19
CU20230011A7 (es) 2023-12-07
AU2021325081A1 (en) 2023-04-13
WO2022036137A1 (en) 2022-02-17
US20230374455A1 (en) 2023-11-23

Similar Documents

Publication Publication Date Title
JP7420856B2 (ja) T細胞を製造する組成物及び方法
KR102756321B1 (ko) T 세포 제조 조성물 및 방법
KR20230074719A (ko) T 세포 제조 조성물 및 방법
WO2023064930A1 (en) T cell manufacturing compositions and methods
RU2793344C2 (ru) Композиции и способы для производства т-клеток
WO2025227066A2 (en) Ras vaccine compositions and methods of use
WO2025179050A2 (en) Vaccine compositions and methods of use
CN118574629A (zh) T细胞制备组合物和方法
HK40115457A (zh) T细胞制备组合物和方法
HK40071072A (en) T cell manufacturing compositions and methods
HK40039283A (en) T cell manufacturing compositions and methods
HK40071072B (zh) T细胞制备组合物和方法
HK40039283B (zh) T细胞制备组合物和方法

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20230310

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20240809

Comment text: Request for Examination of Application