KR20230032868A - Honey foam - Google Patents

Abstract

The present invention relates to an improved wound product which does not have the same antibacterial and wound healing effects as Manuka honey, but can be mixed with therapeutic anesthetic, can be scented, can be stored in a spray dispenser, can be used with a straw, and thus can be applied as a foam. The present invention provides the option of attaching a straw to the dispenser hole to dispense honey foam in deep tunneling wounds. The present invention can be applied by spraying directly onto a wound or burn or by spraying the same onto a sterile sponge.

Description

Honey Foam {HONEY FOAM}

The present invention relates to medical products, and more particularly to honey foam. This honey foam can be mixed with anesthetics in a spray applicator with or without a straw for contaminated, uncontaminated wounds, decubitus ulcers, deep ulcers, burns and pre-surgical scrubs.

This section provides background information relating to the present disclosure that is not necessarily prior art.

The present invention is an improvement that does not have the same antibacterial and wound healing effects as manuka honey, but can be mixed with a therapeutic anesthetic, stored in a spray dispenser, used with a straw, and applied as a foam. Regarding the wound product, Manuka honey comes from Australia and New Zealand, as that is where the Australian plum (Leptospermum scoparium) tree grows. Manuka honey has been studied for its antibacterial and wound healing properties, and honey containing moderate amounts of methylglyoxal has been approved for use as a wound healing honey. The problem with Manuka Honey is that it is limited to these regions, production of Manuka Honey is limited, and the price is very high. Due to cost, many people cannot afford to use Manuka Honey. Honey has been used for wound healing and as a natural skin moisturizer. It has been known for decades that wet wounds heal faster than dry wounds. Table honey contains hydrogen peroxide instead of methylglyoxal. The present inventors have found that adding hydrogen peroxide to honey produces a semi-solid foam. The hydrogen peroxide adds an antibacterial effect to the honey and the foam allows more coverage with less honey to cover a larger surface area where less honey is needed. Foam honey can also be used for deeper wounds such as tunneling pressure sore ulcers. Wound honey not only protects the wound from infection, but also maintains its ideal moisture content. Honey can be mixed and stored with other natural antibacterial sweeteners such as molasses, syrup, artificial honey or nectar. It may be mixed with natural or synthetic anesthetics or fragrances.

Two methods of protecting a product from microbial spoilage are water activity and acidity. Products with low water activity can be damaged because there is not enough moisture for bacteria or fungi to grow. Acidity or low pH prevents product damage by damaging microorganisms. Honey has a naturally low water activity and acidity. Ingredients with low water activity and low acidity, such as the non-limiting example of oxalic acid, are added to further protect the product.

Honey is naturally preserved with hydrogen peroxide, polyphenols and organic acids. However, while this combination prevents bacteria from growing on the honey, it is not necessarily bactericidal. Some honeys with higher levels of hydrogen peroxide, such as honeydew honey, are more bactericidal at lower concentrations than Manuka honey. There is a synergistic bactericidal effect between the organic acid and hydrogen peroxide. Honey contains various organic acids. Hydrogen peroxide can be added to honey for an antiseptic effect. See Table 1.

Synergistic bactericidal combination of hydrogen peroxide and organic acids in percentage. mountain bacterial strain mbc acid MBC
hydrogen peroxide MBC combination
bovine albumin + yeast extract 1%
acid/H2O2 formic acid enterococci 5% 12.5% 0.625% / 3.12% formic acid Staphylococcus aureus 1.25% 3.12% 0.312% / 1.56% formic acid Listeria 1.56% 6.25% 0.625% / 0.78% formic acid Pseudomonas aeruginosa 0.025% 1.56% 0.025% / 0.39% acetic Pseudomonas aeruginosa 0.625% 1.56% 0.625% / 0.39%

Anesthetics such as lidocaine also have antibacterial effects.

Minimum inhibitory concentration of lidocaine microbe MIC
mg/ml Staphylococcus aureus ATCC 29213 20 Escherichia coli ATCC 25922 5

Some phytochemicals also have anesthetic effects.

A phytochemical with local anesthetic activity. class Phytochemical ester cocaine Acyclic monoterpinoids linalool Acyclic monoterpinoids linalyl acetate Acyclic monoterpinoids geranium Acyclic monoterpinoids Neral Acyclic monoterpinoids citronellol Acyclic monoterpinoids Citronellal Acyclic monoterpinoids Geraniol Acyclic monoterpinoids Geranyl Acetate monocyclic monoterpinoids menthol monocyclic monoterpinoids cement monocyclic monoterpinoids thymol monocyclic monoterpinoids carvacrol monocyclic monoterpinoids Terpineol monocyclic monoterpinoids Terpinene monocyclic monoterpinoids Mentone monocyclic monoterpinoids carbon monocyclic monoterpinoids fullegon monocyclic monoterpinoids limonene monocyclic monoterpinoids Eugenol bicyclic monoterpinoids eucalyptol bicyclic monoterpinoids cineole bicyclic monoterpinoids pinene bicyclic monoterpinoids penzone bicyclic monoterpinoids Borneol bicyclic monoterpinoids bornyl acetate bicyclic monoterpinoids Kampen bicyclic monoterpinoids cinnamic aldehyde bicyclic monoterpinoids anethol bicyclic monoterpinoids Estragol Sesquiterpenoids Furanodiene Sesquiterpenoids Methoxyfuranoguaia Sesquiterpenoids Caryophyllene Sesquiterpenoids nerolidol flavonols quercetin flavonols Catechin flavonols epicatechin flavonols Epigallocatechin flavonols Epigallocatechin Gallate anthocyanidins pelargonidin anthocyanidins Cyanidin anthocyanidins delphinidin isoflavones Genistein isoflavones die jane stilvenoid resveratrol

Advantageously, a non-limiting use of this product may include a spray bottle with a dispensing straw for deep wounds. The product may include hydrogen peroxide at a concentration of 0.01% to 10%, an anesthetic agent at a concentration of 0.1% to 10%, and a fragrance at a concentration of 0.01% to 3%. Another embodiment is for wounds on a whipped topping dispenser, sponge top, or a honey foam dispenser with a sponge containing honey foam for burns, exposed wounds, contaminated wounds, tunneling wounds, or surgical use. includes honey

According to the present disclosure, the present invention is an improved natural honey foam or honey substitute foam product that can be used as a medical product. An anesthetic and/or fragrance may be added as needed and the product may be dispensed from a straw tip applicator, sponge tip applicator or sponge for scrubbing wounds, burns, deep wounds or pre-surgical scrubs. This product may be on par with Manuka Honey in its antibacterial and wound healing properties, but may cost less. One example of several potential medical products not limiting this patent application is sterile medical honey mixed with 0.1%-4% lidocaine, 0.01-0.05% clove essential oil and 0.01-1% star anise essential oil, which contains 0.01%- Dispensed from a pressurized spray bottle containing 1% hydrogen peroxide. A variation is a sterile medical honey and 6.5% pomegranate syrup product in a whipped dispenser with nitrous oxide. The dispenser nozzle can be pushed to one side to spray the product directly onto the pressure sore ulcer. Another example is wound honey in a foam-top dispenser. When you press the handle, hydrogen peroxide is released into the honey and foam honey is ejected from the dispenser. A fourth example could be a sterile honey preoperative scrub packaged in a sealed sponge with a capsule containing hydrogen peroxide. When ready to use, unwrap the sponge from its sterile wrapper, squeeze the hydrogen peroxide in the capsule to release the hydrogen peroxide into the sponge, and apply the honey foam to wounds, burns, or as a pre-surgery scrub.

These products may contain artificial honey, molasses, syrups or fruit juices for better antibacterial effect or lower cost. They may contain synthetic or natural anesthetics to reduce pain. These can contain synthetic or natural fragrances that can create a pleasant fragrance and mask odors. Because it uses cheaper honey, the cost is greatly reduced. Versatile Wound Honey Foam / Burn Honey Foam / Surgical Disinfectant Honey Foam can be used in multiple departments, saving time and money in hospitals, burn centers, surgical centers, and wound centers.

The following description of technology is only illustrative in nature of the subject matter, manufacture and use of one or more of the inventions, and specific inventions claimed in this application or other applications that may be filed claiming priority to this application, or patents issued therefrom. It is not intended to limit the scope, application or use of With respect to the disclosed methods, the order of steps presented is illustrative in nature, and thus the order of steps may differ in various embodiments, including where certain steps may be performed concurrently. The singular expressions “A” and “an” as used herein indicate the presence of “at least one” of the item; Where possible, there may be several of these items. Except where expressly indicated otherwise, all figures in this description are to be understood as modified by the word "about" and all geometric and spatial descriptors are to be read as modified by the word "substantially" when describing the widest extent of the technology. It should be understood as modified. "About" when applied to a numeric value indicates that a calculation or measurement tolerates some imprecision in the value (with some approximation to the accuracy of the value; approximately or reasonably close to the value; nearly). As used herein, “about” and/or “substantially” refers to such parameters, unless for any reason the imprecision provided by “about” and/or “substantially” is not otherwise understood in the art in this general sense. Indicates at least variations that may occur from the usual methods of measurement or use.

Although the open-ended term “comprising” as a synonym for non-limiting terms such as including, containing or having is used herein to describe and claim embodiments of the present technology, embodiments may alternatively be used. may be described using more restrictive terms such as “consisting of” or “consisting essentially of”. Thus, for any given embodiment reciting a material, component, or process step, the disclosure also covers the additional material, component, or process (even if such additional material, component, or process is not explicitly recited in the present application). Embodiments consisting of or consisting essentially of such materials, components, or process steps, excluding (to constitute essentially) and excluding (to constitute essentially) any additional materials, components, or processes that affect significant characteristics of the embodiments. specifically include For example, a recitation of a configuration or process that recites elements A, B, and C, except for element D, which may be cited in a particular technical field, even if element D is not explicitly described as excluded herein, A , B and C are contemplated.

The beginning of a range is inclusive of the endpoints unless otherwise specified, and includes all unique values and further subdivided ranges within the entire range. Thus, for example, a range of “from A to B” or “from about A to about B” includes A and B. Disclosure of values and value ranges for particular parameters (eg, amounts, weight percentages, etc.) does not exclude other values and value ranges useful herein. It is contemplated that two or more specific illustrated values for a given parameter may define endpoints for a range of values that may be claimed for the parameter. For example, if a parameter X is illustrated herein as having the value A and is also illustrated as having the value Z, it is envisioned that the parameter X can have a value range from about A to about Z. Similarly, disclosure of two or more ranges of values for a parameter (whether such ranges are interleaved, overlapping, or separate) is intended to include all possible combinations of ranges for values that can be claimed using the endpoints of the disclosed ranges. is envisioned as For example, if parameter X is exemplified herein as having a value in the range of 1-10, 2-9 or 3-8, then parameter X is also 1-9, 1-8, 1-3, 1-2, It may have other ranges of values including 2-10, 2-8, 2-3, 3-10, 3-9, etc.

The present disclosure relates to hydrogen peroxide mixed with honey or a honey substitute as described in more detail below.

One example of several potential medical products not limiting this patent application is sterile medical honey mixed with 4% lidocaine, 0.03% clove essential oil, 0.02% star anise essential oil and 1% hydrogen peroxide dispensed from a spray dispenser. The dispenser, one of several potential examples, is a 200ml pressurized spray bottle with a straw. This gives you the option of attaching a straw to the dispenser hole for dispensing honey foam in deep tunneling wounds. The straw can be removed and sprayed directly on the wound or burn, or a sterile sponge can be applied.

A non-limiting variant of this patent is a sterile honey 93.5% and sterile pomegranate syrup 6.5% product in a 6.5 ounce whipped dispenser with nitrous oxide. The dispenser nozzle can be pushed to one side to spray the product directly onto the pressure sore ulcer.

Another non-limiting example of this patent is the sore honey in a 3.5 oz sponge top dispenser. When the handle of the flexible plastic dispenser is pressed, hydrogen peroxide is released from the bottom of the dispenser as 100% Leptospermum honey, and honey foam comes out from the dispenser to moisten and apply with a sponge.

A fourth non-limiting example of this patent is sterile buckwheat honey soaked in a 2 ½" X 3 ½" pre-surgical scrub sponge with capsules containing 50ml hydrogen peroxide in the sponge. When ready to use, unwrap the sponge from its sterile wrapper, squeeze the hydrogen peroxide in the capsule, the hydrogen peroxide is released into the sponge, and the honey foam is applied as a scrub for wounds, burns, or pre-surgery.

It is desirable that the water activity of the supplement is low. Honey naturally has a low water activity, containing about 17% water. Other additional wetting agents may include nitric acid, glucose, fructose, glycerol, glycine, glucose, malic acid, salts, sorbitol, sucrose and tartaric acid. A skilled artisan can select any suitable wetting agent as desired. For example, the supplement may have a water activity of 0.86.

It is also desirable for the product to have a low pH because it inhibits microbes. The pH of honey is generally between 3.5 and 5.5. Acid lowers pH. Some acids, such as formic acid, acetic acid, oxalic acid, nitric acid, lactic acid, succinic acid, tartaric acid, citric acid, propionic acid, sulfuric acid, benzoic acid, sorbic acid, sulphate, phosphoric acid, mandelic acid, and adipic acid, have a synergistic antibacterial effect with hydrogen peroxide against bacteria. . Hydrogen peroxide is found naturally in honeysuckle, not mauka.

Also, as may be set forth in the claims herein, language “consisting of” is intended to exclude any ingredient not specified in the claims. Therefore, supplements made up of specific ingredients described above contain only those ingredients.

Exemplary embodiments are provided so that this disclosure will be thorough and will fully convey its scope to those skilled in the art. Numerous specific details are set forth, such as examples of specific components, devices and methods, to provide a thorough understanding of embodiments of the present disclosure. It will be apparent to those skilled in the art that no specific details need be used, and that the illustrative embodiments may be embodied in many different forms, and none should be construed as limiting the scope of the present disclosure. In some exemplary embodiments, well-known processes, well-known device structures and well-known technologies are not described in detail. Equivalent changes, modifications and variations of some embodiments, materials, compositions and methods may be made within the scope of the present technology with substantially similar results.

Claims (14)

Before wounds, burns or surgery (including honey, artificial honey, molasses, nectar, or syrup mixed with hydrogen peroxide or carbon dioxide in a concentration sufficient to cause the product to form a foam) pre-surgical) scrubs, products. The product of claim 1 , stored in a pressurized container. The product of claim 1 , which can be applied using a straw. The product of claim 1 , mixed with an anesthetic. The product of claim 1 , mixed with an acid. The product of claim 1 , wherein the water activity level is less than 0.87. Honey foam combined with natural or synthetic anesthetics. 8. The product of claim 7, mixed with lidocaine at a concentration of less than 5.1%. 8. The product according to claim 7, mixed with clove essential oil at a concentration of less than 0.06%. 8. The product according to claim 7, mixed with star anise essential oil at a concentration of less than 0.5%. 8. The product of claim 7, mixed with 4% lidocaine and 0.03% clove essential oil. A process in which hydrogen peroxide, carbon dioxide or nitrous oxide is mixed with at least one of honey, artificial honey, molasses, fruit juice, syrup to produce a foam product. 13. The process of claim 12, which produces honey foam. 13. The product of claim 12, created from material stored in a sponge or sponge-top dispenser.