KR20230027654A - Cell and fluid collecting device for screening of endometrial and ovarian cancers - Google Patents

Abstract

The present invention relates to a cell and fluid collecting device for screening of endometrial and ovarian cancers, which comprises a base configured to be insertable into the vaginal canal, a plurality of elastic parts one end of which is fixed to the base and which are spaced apart along the circumference of a receiving space, and a receiving part which is closed at one end, has an opening at the other end, and is configured to define the receiving space therein. At least a portion of the receiving part is connected to the plurality of elastic parts so as to be deformed by the plurality of elastic parts. The cell and fluid collecting device for screening of endometrial and ovarian cancers according to the present invention can collect cells and body fluids within a woman vaginal canal for a predetermined period of time. Therefore, screening tests for endometrial and ovarian cancers can be performed minimally invasively. In addition, after completing the collection of cells and fluid, the collection device can be removed in a folded state, minimizing discomfort which can occur during insertion and removal.

Description

Cell and fluid collecting device for screening of endometrial and ovarian cancers {Cell and fluid collecting device for screening of endometrial and ovarian cancers}

This study was conducted with the support of the Korea Health Industry Development Institute's health and medical technology R&D project (project identification number: HI19C0664) funded by the Ministry of Health and Welfare.

The present invention relates to a device for collecting cells and body fluid for endometrial cancer and ovarian cancer screening, and more particularly, to a device for collecting cells and body fluid by being placed in the human body for a certain period of time.

Ovarian cancer accounts for about 20% of gynecological cancers, and the peak age is known to be 50 years. Most of the cases are asymptomatic until metastasis occurs in the peritoneal cavity after cancer has occurred, and at the time of initial diagnosis, about 2/3 of them are already found in an advanced state (stage 3 or higher), so it is the most common gynecological cancer that occurs in the female genital tract. It is known as a cancer with a poor prognosis. In particular, epithelial ovarian cancer, which accounts for about 90% of ovarian cancer, is mostly found in advanced stage 3 or higher, and in this case, the 5-year survival rate is reported to be about 40%.

On the other hand, although the diagnosis and staging of ovarian cancer is performed through surgery, if there is a suspected ovarian cancer lesion before surgery, tests are needed to confirm the progress of the disease and whether it has metastasized to surrounding organs. First, a pelvic ultrasound is performed to check the external shape and size of the tumor, and as a hematological test, a tumor marker (CA-125) with sensitivity to ovarian cancer is tested. Afterwards, imaging diagnosis including computed tomography (CT) or magnetic resonance imaging (MRI) and endoscopy of the digestive organs are performed to confirm the progress of the disease.

However, there is no groundbreaking test method for early detection of ovarian cancer, and methods such as tumor marker test (CA-125) and pelvic ultrasound are known to be useful. However, regular vaginal ultrasonography and CA-125 testing do not reduce mortality from ovarian cancer.

On the other hand, it has recently been reported that DNA associated with ovarian cancer / endometrial cancer can be detected through conventional cervical cytology, and it is possible to obtain a more effective sample by improving it. It has also been reported that endometrial cancer and ovarian cancer can be diagnosed before clinical symptoms appear.

In addition, studies have reported that CA-125 and HE4, which are used as blood tumor markers for ovarian cancer, are detected 38 times and 23 times higher in uterine lavage fluid than in blood, respectively, and can be usefully used for diagnosis. Korean Patent Registration No. 2260999 is disclosed in relation to a device placed in the uterus for such diagnosis. However, a device capable of collecting cells or body fluids shed or secreted from the endometrium and fallopian tubes has not yet been developed. Therefore, there is a need to develop a device capable of collecting cells and body fluid secreted from the endometrium and fallopian tube in a minimally invasive, effective, and sufficient manner.

Korean Registered Patent No. 2,260,999

An object of the present invention is to provide a cell and body fluid collection device capable of collecting cells and body fluids shed from fallopian tubes and endometrium in a minimally invasive, effective and sufficient manner for conventional endometrial and ovarian cancer screening tests.

As a means of solving the above problems, a base configured to be inserted into the vaginal canal, one end fixed to the base, a plurality of elastic parts disposed spaced apart along the circumference of the accommodation space, and one end closed, the other end formed with an opening, , Cells and body fluids for endometrial cancer and ovarian cancer screening, including an accommodating portion configured to define an accommodating space therein, wherein at least a portion of the accommodating portion is connected to the plurality of elastic portions so as to be deformable by the plurality of elastic portions. A collection device may be provided.

Meanwhile, the elastic part may be configured to expand the receiving part when there is no external force.

Meanwhile, a guide portion extending inwardly from one side of the accommodation unit may be included to prevent cells and body fluids accommodated in the accommodation space from leaking out.

In addition, the guide part may be formed to extend inwardly at a point spaced apart from the end of the receiving part by a predetermined distance.

On the other hand, the guide unit, when the collecting device is placed in the vaginal canal, at least a part of the outer surface is configured to come into close contact with the cervix, and a hollow can be formed so that body fluid and cells discharged from the uterus can pass through and be accommodated in the accommodation space.

Furthermore, the guide part may be configured to be deformed dependently according to the deformation of the accommodation part.

In addition, the guide part may be configured to be deformed together when the receiving part is contracted by an external force so that the hollow can be substantially closed.

On the other hand, the end of the receiving portion may be formed inclined so as to be in close contact with the cervix when the collecting device is placed in the vaginal canal.

Also, an end portion of the accommodating portion may be deformed into a substantially elliptical shape in the deployed position.

On the other hand, it extends to a predetermined length and further includes a housing having an insertion space formed therein along the longitudinal direction and a pushing bar configured to be inserted from one side of the housing, and the base, the elastic part, the receiving part and the guide part are inserted It may be configured to be inserted into the other side of the space.

Meanwhile, the elastic part, the accommodating part, and the guide part may be arranged in a contracted form within the housing, and may be configured to be deployed by the elastic part as the elastic part, the accommodating part, and the guide part come out of the housing.

In addition, the side wall of the accommodating unit may be formed in a curved surface corresponding to an anatomical space in the vaginal canal adjacent to the cervix in the deployed position. On the other hand, the base is formed to a predetermined length, an external base in which a hollow is formed in the longitudinal direction, an internal base configured to reciprocate a predetermined distance by inserting at least a part of the external base into the external base, and separating the internal base from the external base. It includes a spring for applying an elastic force so that a plurality of elastic parts may be connected to one side of the inner base.

In addition, the base may further include a locking portion configured to fix the position of the inner base when the inner base is inserted into the outer base to a predetermined length.

Furthermore, the base may further include an unlocking unit configured to unlock the locking unit.

In addition, the unlocking unit is configured to be inserted into the inner base in the longitudinal direction, and one side may be configured to be associated with the locking unit.

Meanwhile, the locking unit may include a protrusion protruding radially from the inner base and/or the outer base, and the unlocking unit may be configured to release the lock by pressing the protrusion in the radial direction as it is inserted into the inner base.

On the other hand, it is provided on one side of the base, and may further include a traction part configured to be extended to a predetermined length and pulled to pull the collecting device out in a state disposed in the vaginal canal.

The apparatus for collecting cells and body fluids for endometrial cancer and ovarian cancer screening according to the present invention can collect cells and body fluids from the vaginal canal of a woman for a certain period of time. Therefore, screening tests for ovarian cancer and endometrial cancer can be performed minimally invasively.

In addition, after the cell and bodily fluid collection is completed, the collection device can be removed in a folded state, thereby minimizing discomfort that may occur during the insertion and removal process.

1 is a perspective view of a cell and body fluid collection device for screening endometrial cancer and ovarian cancer according to a first embodiment of the present invention.
2 is an exploded perspective view of a cell and body fluid collection device for endometrial cancer and ovarian cancer screening tests according to a first embodiment.
3 is a cross-sectional view of a cell and body fluid collection device for endometrial cancer and ovarian cancer screening tests according to a first embodiment.
4 is an operating state diagram of a cell and body fluid collection device for endometrial cancer and ovarian cancer screening tests according to the first embodiment.
5 is a diagram showing a state of use of a cell and body fluid collection device for endometrial cancer and ovarian cancer screening tests according to the first embodiment.
6 is another operating state diagram of the cell and body fluid collection device for endometrial cancer and ovarian cancer screening test according to the first embodiment.
FIG. 7 is a diagram illustrating another state of use of the cell and body fluid collection device for endometrial cancer and ovarian cancer screening tests according to the first embodiment.
8 is a perspective view of a cell and body fluid collection device for endometrial cancer and ovarian cancer screening according to a second embodiment of the present invention.
9 and 10 are operational state diagrams of a cell and body fluid collection device for endometrial cancer and ovarian cancer screening tests according to a second embodiment of the present invention.
11 is a perspective view of a cell and body fluid collection device for endometrial cancer and ovarian cancer screening according to a third embodiment of the present invention.
12 is a perspective view of a cell and body fluid collection device for endometrial cancer and ovarian cancer screening according to a fourth embodiment of the present invention.
13 is an operating state diagram of a cell and body fluid collection device for endometrial cancer and ovarian cancer screening according to a fourth embodiment of the present invention.
14 to 18 are operational state diagrams when a user manipulates the cell and body fluid collection device for endometrial cancer and ovarian cancer screening tests according to the fourth embodiment.

Hereinafter, a cell and body fluid collection device for endometrial cancer and ovarian cancer screening according to embodiments of the present invention will be described in detail with reference to the accompanying drawings. In addition, in the description of the following embodiments, the name of each component may be called a different name in the art. However, if they have functional similarity and identity, even if a modified embodiment is employed, it can be regarded as an equivalent configuration. In addition, signs added to each component are described for convenience of description. However, the contents of the drawings in which these symbols are written do not limit each component to the scope in the drawings. Likewise, even if an embodiment in which the configuration in the drawings is partially modified is employed, it can be regarded as an equivalent configuration if there is functional similarity and identity. In addition, in light of the level of a general technician in the art, if it is recognized as a component that should be included, the description thereof will be omitted.

Hereinafter, a cell and body fluid collection device for endometrial cancer and ovarian cancer screening test according to a first embodiment of the present invention will be described with reference to FIGS. 1 to 7 .

1 is a perspective view of a cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening according to the first embodiment of the present invention, and FIG. 2 is a perspective view for endometrial and ovarian cancer screening according to the first embodiment. It is an exploded perspective view of the cell and body fluid collecting device 1, and FIG. 3 is a cross-sectional view of the cell and body fluid collecting device 1 for endometrial cancer and ovarian cancer screening tests according to the first embodiment.

1 is a perspective view of a cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening according to the first embodiment of the present invention, and FIG. 2 is a perspective view for endometrial and ovarian cancer screening according to the first embodiment. It is an exploded perspective view of the cell and body fluid collecting device 1, and FIG. 3 is a cross-sectional view of the cell and body fluid collecting device 1 for endometrial cancer and ovarian cancer screening tests according to the first embodiment.

1 to 3, the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening according to the first embodiment of the present invention has an accommodation space 310 inside and cells discharged from the uterus. And it is configured to collect the bodily fluid (S).

The cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening according to the first embodiment of the present invention includes a base 100, an elastic part 200, a receiving part 300, and a guide part 400. can be configured to include

The base 100 becomes a base on which the elastic part 200 and the accommodating part 300, which will be described later, can be fixed. The base 100 may be configured to a diameter capable of being inserted through the vaginal canal. The base 100 may be made of a hard material so that the elastic part 200 to be described later is connected and fixed at one side.

The elastic part 200 is composed of a plurality, and may be configured such that the ends of each other can be maintained in an unfolded state when there is no external force. The lower end of each elastic part 200 may be fixed to the base 100 based on FIGS. 1 to 3 . A plurality of elastic parts 200 may be radially disposed on the base 100 . Each of the elastic parts 200 may be made of a material having appropriate elasticity so as to be deformed by an external force. In addition, the elasticity of the elastic part 200 may be configured to have a degree that tissue is not damaged by the restoring force. When inserted into the vaginal canal, it may be configured to conform to some extent and be deformed by an external force caused by the vaginal canal.

An accommodation space 310 capable of accommodating cells and body fluids S may be defined inside the accommodation unit 300 . The receiving part 300 is configured in a form with one side open and may be configured in a concave form. The accommodating part 300 may be connected to at least a portion of each of the elastic parts 200 so that the elastic parts 200 can be deformed. When the receiving part 300 is deformed by the elastic part 200 or an external force, at least a portion of the receiving part 300 may be folded or deformed so that the outer diameter may be changed. As an example, the accommodating part 300 may be configured in the form of a membrane through which liquid does not pass.

The guide unit 400 may be configured to prevent leakage of cells and body fluids (S) accommodated in the accommodation unit 300 . The guide part 400 may be formed to extend inwardly to a predetermined width on the upper side of the accommodating part 300 . A hollow 410 may be formed in the central portion of the guide part 400 so that cells and body fluids (S) leaked from the uterus pass through and enter the accommodation space 310 . The guide part 400 may be configured to be deformed dependently by the deformation of the accommodating part 300 . The guide part 400 is configured in the form of a thin film similarly to the accommodating part 300 and can be configured to be relatively freely deformed.

The elastic part 200, the receiving part 300, and the guide part 400 described above may be configured at an angle with an inclined upper side as a whole. This is to prevent tissue damage and minimize foreign body sensation when the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening is inserted into the vaginal canal, since the uterus is tilted forward in the human body. In addition, since the guide part 400 is obliquely arranged, it can adhere closely to the cervix, and the opening of the guide part 400 exposes the opening of the cervix to the accommodation space 310 so that cells and body fluids S can be efficiently accommodated. It helps to enter the space 310.

Meanwhile, the aforementioned base 100, elastic part 200, accommodating part 300, and guide part 400 may be made of a non-toxic material so that there is no effect even if they are placed in the human body for a predetermined period of time.

4 is an operating state diagram of the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening tests according to the first embodiment.

Referring to FIG. 4(a), the form of the first embodiment is shown when there is no external force. When there is no external force, the receiving part 300 is expanded to the maximum size by receiving force in the direction in which it is expanded by the elastic part 200 . At this time, the guide part 400 and the accommodating part 300 may also be deformed in a fully unfolded state by the elastic part 200 . That is, the elastic part 200 acts as a restoring force in the direction of deploying the accommodating part 300, but the maximum size may be limited by the elasticity of the accommodating part 300 itself. The accommodating part 300 may have an elliptical end in a state in which it is unfolded (expanded) to the maximum size, and at this time, the guide part 400 may also be unfolded in an elliptical shape as a whole. At this time, at least a part of the guide part 400 may be concavely deformed on the cross section of the inclined receiving part 300 . When the guide part 400 is unfolded to its maximum size, since the support force exerted in the thickness direction from the elastic part around the hollow 410 is not transmitted, when the upper surface is in close contact with the cervix, it is naturally concave inside the accommodation space 310. transformation can be made.

Referring to FIG. 4(b) , when an external force in a radial direction is applied, the elastic part 200, the accommodating part 300, and the guide part 400 may be converted into a folded form (contracted form). That is, the elastic part 200, the accommodating part 300, and the guide part 400 may be deformed conformally by an external force. At this time, the sidewall of the accommodating part 300 is deformed in the circumferential direction to the maximum. Some of the sidewalls of the accommodating portion 300 are deformed along with the elastic portion 200, and at least a portion of the portion to which the elastic portion 200 is not connected may be deformed while being folded and overlapped. At least a part of the side wall of the accommodating part 300 may be configured as a curved surface so that it can be mounted in accordance with the anatomical space adjacent to the cervix when inserted into the vagina. Of course, even in this case, when an external force is applied to the side wall of the accommodating part 300 by the cervix and vaginal canal, contraction may be achieved to some extent in compliance with the external force.

Meanwhile, at this time, the guide portion 400 is deformed as the accommodating portion 300 contracts, and the opening may be substantially closed. When the guide part 400 is also contracted and folded according to the contraction and folding of the accommodating part 300 and the opening of the guide part 400 is substantially closed, the cells and body fluids S accommodated in the accommodating space 310 It is possible to prevent outflow and prevent external substances from entering the receiving space 310 .

5 is a diagram showing a state of use of the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening tests according to the first embodiment.

Referring to FIG. 5 , the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening according to the first embodiment of the present invention can be inserted and placed in a position adjacent to the uterine (U) cervix in the vaginal canal. . In the mounted state, the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening can be mounted in a deployed (unfolded) state by the elastic part 200 . In the mounted state, the cervix may be in close contact with the upper surface of the guide part 400, and body fluids and cells discharged from the uterine cavity may enter the accommodation space 310 through the hollow of the guide part 400 and be accommodated therein. . The cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening is placed in the vaginal canal V for a predetermined period of time, and when the cells and body fluid S are collected for a predetermined period of time, they are taken out of the body, and the receiving space 310 ), it is possible to diagnose endometrial cancer and ovarian cancer at an early stage.

6 is another operating state diagram of the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening tests according to the first embodiment.

Referring to FIG. 6 , in the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening according to the first embodiment of the present invention, cells and body fluids accommodated in the accommodation space 310 (S ) can be minimized. The user can lead a daily life in various postures with the cell and body fluid collection device 1 for endometrial and ovarian cancer screening tests inserted. And the body fluid collecting device 1 may also have a different posture. Although leakage to the outside can be prevented to some extent by the pressure of the vaginal canal, the guide part 400 extends a predetermined length from the inner surface of the receiving part 300 toward the center in order to more surely prevent leakage. Therefore, even if the accommodation part 300 is inclined, the outflow of cells and body fluid S can be prevented by the guide part 400 . In addition, since the upper surface of the guide part 400 is in close contact with the cervix, a sealing effect can be exerted even if the user's posture changes, and leakage due to the opening of the guide part 400 can also be prevented.

FIG. 7 is another use state diagram of the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening tests according to the first embodiment.

Referring to FIG. 7 , the cell and body fluid collection device 1 for screening for endometrial cancer and ovarian cancer according to the first embodiment is configured to be inserted through the vaginal canal V and into the cervix of the uterus U. The guide portion may be disposed in a closely spaced position. Meanwhile, when passing through the vaginal canal (V), it may be configured to move along the vaginal canal (V) in a contracted state. Therefore, in the process of inserting or withdrawing the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening through the vaginal canal V, the user's discomfort and tissue damage can be minimized. On the other hand, in the process of withdrawing through the vaginal canal V, the accommodating part 300 and the guide part 400 are contracted, and the opening of the guide part 400 can be substantially closed, so that the cells collected in the accommodating space 310 and The bodily fluid (S) can be safely secured without leakage.

Hereinafter, a cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening test according to a second embodiment of the present invention will be described with reference to FIGS. 8 to 10 .

The following embodiments may also include the same components as the above-described embodiments, and descriptions of the same configurations are omitted to avoid redundant description, and configurations with differences will be described.

8 is a perspective view of a cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening according to a second embodiment of the present invention.

Referring to FIG. 8 , a cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening according to a second embodiment of the present invention may further include a housing 510 and a pushing bar 520. there is. The housing 510 and the pushing bar 520 are configured so that the user can withdraw the base 100, the elastic part 200, the receiving part 300, and the guide part 400 forward by a pressing motion.

The housing 510 may be configured to cover the base 100, the elastic part 200, the accommodating part 300, and the guide part 400. The housing 510 is formed to extend to a predetermined length, and an insertion space may be provided inside along the longitudinal direction. The base 100, the elastic part 200, the accommodating part 300, and the guide may be inserted into the insertion space along the longitudinal direction in a folded state (contracted state). A support portion 511 extending in a radial direction may be provided on an outer surface of the housing 510 . The support part 511 is provided to fix the housing 510 when a user presses the pushing bar 520, which will be described later.

One side of the pushing bar 520 may be configured to be inserted into the insertion space of the housing 510 in the longitudinal direction. The pushing bar 520 is configured to support the end of the base 100 disposed in the insertion space. When the user enters the pushing bar 520 into the insertion space, the end of the pushing bar 520 pushes the base 100 in the longitudinal direction and eventually the base 100, the elastic part 200, the receiving part 300 and The guide part 400 can come out of the insertion space.

Meanwhile, the housing 510 and the pushing bar 520 may be removed by placing the base 100, the elastic part 200, the receiving part 300, and the guide part 400 in appropriate positions in the vaginal canal and then pulling them out of the body. there is.

9 and 10 are operational state diagrams of the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening tests according to the second embodiment of the present invention.

Referring to FIG. 9 , when the user presses the pushing bar 520, the end of the pushing bar 520 pushes the base 100, and the elastic part 200 and the receiving part 300 are formed at the end of the housing 510. And the guide part 400 gradually comes out to the outside.

At the initial position, the elastic part 200, the accommodating part 300, and the guide part 400 receive an external force from the inner surface of the housing 510 and maintain a contracted state. Then, as the pushing bar 520 is pressed, the elastic part 200 and the accommodating part 300 rotate so that the portion receiving the external force by the housing 510 gradually decreases. Therefore, as the pushing bar 520 is pressed, the elastic part 200, the accommodating part 300, and the guide part 400 come out of the housing 510, and are gradually unfolded by the restoring force of the elastic part 200. .

Referring to FIG. 10 , when the elastic part 200, the accommodating part 300, and the guide part 400 come out of the insertion space by completely pushing the pushing bar 520, deployment may be completed. At this time, when there is no external force, the accommodation space 310 may expand to a maximum volume. However, when unfolded in the vaginal canal, it will substantially expand to a size slightly smaller than its maximum size due to pressure by the inner wall of the vaginal canal.

On the other hand, although not shown, as shown in FIG. 10, when the base 100, the elastic part 200, the receiving part 300, and the guide part 400 are properly disposed in the vaginal canal, the user can use the housing 510 and By withdrawing the pushing bar 520 into the vaginal canal, the arrangement of the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening may be completed.

Hereinafter, a third embodiment will be described with reference to FIG. 11 .

11 is a perspective view of a cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening according to a third embodiment of the present invention.

Referring to FIG. 11 , in the cell and body fluid collection device 1 for endometrial and ovarian cancer screening according to the third embodiment of the present invention, after cells and body fluids (S) are collected, endometrial and ovarian cancer A traction unit 600 may be included to smoothly pull out the cell and body fluid collection device 1 for the screening test.

One side of the traction unit 600 is connected to the base 100 and may be configured such that a user can pull one side of the traction unit 600 disposed at the entrance of the vaginal canal or at a point close to the entrance. The traction unit 600 may be made of a fiber material to minimize the foreign body sensation. When the user pulls the traction part 600, the elastic part 200, the accommodating part 300, and the guide part 400 of the cell and body fluid collection device 1 for screening endometrial cancer and ovarian cancer are moved to the traction part. It can come out along the vaginal canal along 600. Meanwhile, at this time, the elastic part 200, the accommodating part 300, and the guide part 400 can come out of the vaginal canal in a naturally contracted state by the pressure of the vaginal canal.

Hereinafter, a cell and body fluid collection device 1 for screening for endometrial cancer and ovarian cancer according to a fourth embodiment according to the present invention will be described with reference to FIGS. 12 to 18 .

12 is a perspective view of a cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening according to a fourth embodiment of the present invention.

Referring to FIG. 12 , in the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening according to the fourth embodiment of the present invention, the user can use the elastic part 200, the accommodating part 300, and the guide part 400 ) can be configured to actively switch to a unfolded or folded state.

In this embodiment, the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening includes a base 100 including an external base 120, an internal base 110, a spring 150, and a fund release unit 140. ). In addition, a storage unit 350 configured to store cells and body fluids collected at the rear of the accommodation unit 300 may be included.

The outer base 120 is composed of a tubular member, may be formed to extend to a predetermined length, and may have a hollow formed on the inside in the longitudinal direction. The outer base 120 may be configured such that the inner base 100, a part of the elastic part 200, and a part of the receiving part 300 can be inserted therein. When some of the elastic part 200 and the receiving part 300 are inserted into the outer base 120, they are supported by the inner surface of the outer base 120 according to the length of the insertion, and the degree of deployment may vary.

At least a part of the inner base 110 is configured to be inserted into the outer base 120, and can be configured to reciprocate a predetermined distance in the longitudinal direction on the outer base 120. At least one of the elastic part 200 and the accommodating part 300 may be fixed to the center portion of the inner base 110 . Therefore, when adjusting the relative position of the inner base 110 on the outer base 120, the elastic part 200, the accommodating part 300, and the guide part 400 can also be moved together.

That is, the user can adjust the relative lengthwise positions of the inner base 110 and the outer base 120 to convert the elastic part 200, the accommodating part 300, and the guide part 400 into a unfolded or folded form. .

An annular space into which the spring 150 can be inserted may be provided inside the outer base 120 . One side of the spring 150 is supported by the outer base 120, and the other side may be supported by the inner base 110. That is, the spring 150 may provide restoring force in a direction in which the outer base 120 and the inner base 110 are spaced apart from each other.

One side of the inner base 110 and one side of the outer base 120 may include locking parts 130 associated with each other. For example, the locking part 130 may be composed of a pair of cantilever snap fits corresponding to each other. That is, when the inner base 110 is inserted into the outer base 120 over a predetermined distance, the position may be fixed by the locking part 130 .

The unlocking unit 140 may be configured to selectively unlock the locking unit 130 . The unlocking part 140 includes a protruding part 141 protruding in the radial direction, and when the user moves the unlocking part 140, the protruding part 141 presses one side of the locking part 130 to lock it. It is configured to release. On the other hand, the unlocking unit 140 is configured to be movable a predetermined distance in the longitudinal direction from one side of the inner base 110, and when the user presses the unlocking unit 140 to move a predetermined distance to the inside of the internal base 110 In this case, it may be arranged so that unlocking can be performed.

However, the configuration of the locking unit 130 and the unlocking unit described above is only an example and may be modified and applied to various configurations for locking and releasing the position of the inner base 110 .

The storage unit 350 may be configured to prevent cells and body fluids collected in the accommodation space from leaking to the outside when the accommodation unit is contracted while retracting. The storage unit 350 is provided between the accommodating unit 300 and the internal base 110, and may be configured to expand the internal space while extending as the internal base 110 retracts. The storage unit 350 may be configured to have an outer wall that is wrinkled along the longitudinal direction, and may be configured to expand and contract along the external force in the longitudinal direction. The storage unit 350 is provided with a space in which cells and body fluids can be accommodated, and one side can be in fluid communication with the accommodation space 310 of the accommodation unit 300 . Accordingly, bodily fluids and liquids accommodated in the accommodating space can move into the storage unit. The other side of the storage unit 350 may be closed and connected to one side of the inner base 110 . The storage unit 350 may be, for example, a tube in the form of bellows.

13 is a diagram illustrating an operating state of a cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening according to a fourth embodiment of the present invention.

Referring to FIG. 13 , a state in which the user pushes the inner base 110 into the outer base 120 to unfold the elastic part 200, the receiving part 300, and the guide part 400 is shown. The relative position of the inner base 110 with the outer base 120 is fixed in the pushed state by the aforementioned locking part 130, and the elastic part 200, the receiving part 300 and the guide part 400 are deployed. status can be maintained.

14 to 18 are operational state diagrams when a user operates the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening tests according to the fourth embodiment.

Referring to FIG. 14, in an initial state, the inner base 110 is disposed at a position maximally spaced from the outer base 120, and the elastic part 200 and the receiving part 300 are moved toward the inside of the outer base 120. In a state where it is inserted a certain distance, it maintains a contracted state as a whole. In this state, the user can insert the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening into the vaginal canal.

Referring to FIG. 15 , after the user inserts the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening through the vaginal canal, it can be determined that the end is positioned in an appropriate place (as an example, no more if not inserted). At this time, the user may enter the inner base 110 into the outer base 120 to develop the elastic part 200, the accommodating part 300, and the guide part 400. Meanwhile, the storage unit 350 may move forward together with the elastic unit 200, the accommodation unit 300, and the guide unit 400 in a contracted state. When the inner base 110 is inserted into the outer base 120 at a certain distance, a locking operation occurs by the locking part 130 . Meanwhile, this operation may be performed by substantially fixing the position of the inner base 110 and pulling the outer base 120 toward the entrance of the vaginal canal.

On the other hand, the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening is placed in the vaginal canal for a predetermined period of time in the state shown in FIG. 15 to collect cells and body fluid.

Afterwards, referring to FIG. 16 , when removing the cell and body fluid collecting device 1 for endometrial cancer and ovarian cancer screening, the user may press the unlocking unit 140 . The unlocking part 140 may be unlocked by pressing the snap-fit fastening part of the locking part 130 in a radial direction.

Afterwards, referring to FIG. 17 , the internal base 110 is gradually pulled out of the external base 120 by the spring 150, and the storage unit 350 may be expanded first in the initial movement section. The storage unit 350 may contract before the contraction of the accommodating unit 300 or may expand simultaneously with the contraction of the accommodating unit 300 . Therefore, the cells and body fluids collected in the storage unit 300 can be moved into the storage unit due to a pressure difference caused by the expansion of the storage unit 350 . Afterwards, even if the storage unit 300 is contracted, the cells and body fluids have already been moved to the storage unit 350 to some extent, so that leakage of the collected cells and body fluids can be minimized.

Referring to FIG. 18 thereafter, the inner base 110 may be further separated from the outer base 120 by the spring 150, and thus the elastic part 200, the receiving part 300 and the guide part 400 A portion of may be contracted while being inserted into the outer base 120. Then, the user can pull the outer base 120 or the inner base 110 to remove the cell and body fluid collection device 1 for endometrial cancer and ovarian cancer screening outside the vaginal canal.

As described above, the apparatus for collecting cells and body fluids for endometrial cancer and ovarian cancer screening according to the present invention can collect cells and body fluids from the vaginal canal of a woman for a certain period of time. Therefore, screening tests for ovarian cancer and endometrial cancer can be performed minimally invasively.

In addition, after the cell and bodily fluid collection is completed, the collection device can be removed in a folded state, thereby minimizing discomfort that may occur during the insertion and removal process.

1: Cell and body fluid collection device for endometrial and ovarian cancer screening
100: base
110: inner base
120: external base
130: locking part
140: unlocking unit
141: protrusion
150: spring
200: elastic part
300: receiving part
310: receiving space
400: guide part
410: hollow
510: housing
511: support
520: pushing bar
600: traction unit
s: cells and body fluids
U: Uterus
V: vaginal canal

Claims (18)

a base configured to be insertable into the vaginal canal;
a plurality of elastic parts having one end fixed to the base and spaced apart from each other along the circumference of the accommodation space; and
One end is closed, the other end is formed with an opening, and includes an accommodation portion configured to define an accommodation space inside,
The cell and body fluid collection device for screening endometrial cancer and ovarian cancer, wherein at least a part of the receiving part is connected to the plurality of elastic parts so that it can be deformed by the plurality of elastic parts. According to claim 1,
The cell and body fluid collection device for screening endometrial cancer and ovarian cancer, wherein the elastic part is configured to unfold the accommodation part when there is no external force. According to claim 2,
A cell and body fluid collection device for endometrial cancer and ovarian cancer screening including a guide part extending inwardly from one side of the accommodation part to prevent the cells and body fluids accommodated in the accommodation space from leaking out. According to claim 3,
The guide part,
A cell and body fluid collecting device for screening endometrial cancer and ovarian cancer formed by extending inward from a point spaced apart by a predetermined distance from an end of the accommodation part. According to claim 3,
The guide part,
At least a part of the outer surface is configured to be in close contact with the cervix when the collecting device is placed in the vaginal canal,
A cell and body fluid collection device for endometrial cancer and ovarian cancer screening tests in which a hollow is formed so that body fluid and cells discharged from the uterus can pass through and be accommodated in the receiving space. According to claim 5,
The guide part,
A cell and body fluid collection device for screening endometrial cancer and ovarian cancer configured to be deformed dependently according to the deformation of the accommodation unit. According to claim 6,
The guide part,
A cell and body fluid collecting device for screening endometrial cancer and ovarian cancer, the cell and body fluid collection device configured to be deformed together when the accommodation part is contracted by an external force so that the hollow can be substantially closed. According to claim 5,
The cell and body fluid collection device for screening endometrial cancer and ovarian cancer, wherein an end portion of the receiving portion is inclined so as to adhere to the cervix when the collecting device is placed in the vaginal canal. According to claim 8,
The cell and body fluid collection device for screening endometrial cancer and ovarian cancer, wherein the end of the receiving portion is substantially deformed into an elliptical shape in a deployed position. According to claim 4,
a housing extending to a predetermined length and having an insertion space formed therein along the longitudinal direction; and
Further comprising a pushing bar configured to be inserted from one side of the housing,
The base, the elastic part, the accommodating part, and the guide part are configured to be inserted into the other side of the insertion space, and a cell and body fluid collecting device for screening endometrial cancer and ovarian cancer. According to claim 10,
The elastic part, the accommodating part, and the guide part are disposed in a contracted form within the housing,
A cell and body fluid collecting device for screening endometrial cancer and ovarian cancer, wherein the elastic part, the accommodating part, and the guide part are configured to be deployed by the elastic part as they come out of the housing. According to claim 5,
A cell and body fluid collection device for screening endometrial cancer and ovarian cancer, wherein the sidewall of the accommodation portion is formed in a curved surface corresponding to an anatomical space in the vaginal canal adjacent to the cervix in a deployed position. According to claim 1,
The base is
An outer base formed to a predetermined length and having a hollow in the longitudinal direction;
an inner base having at least a portion of the outer base inserted into the outer base to reciprocate a predetermined distance; and
And a spring for applying an elastic force to separate the inner base from the outer base,
The plurality of elastic parts are connected to one side of the inner base to collect cells and body fluids for endometrial cancer and ovarian cancer screening tests. According to claim 13,
The base is
A cell and body fluid collection device for screening endometrial cancer and ovarian cancer, further comprising a locking portion configured to fix a position of the inner base when the inner base is inserted into the outer base to a predetermined length. According to claim 14,
The base is
A cell and body fluid collection device for screening endometrial cancer and ovarian cancer, further comprising an unlocking unit configured to unlock the locking unit. According to claim 15,
The unlocking unit,
It is configured to be inserted in the longitudinal direction into the inner base,
A cell and body fluid collection device for screening endometrial cancer and ovarian cancer, one side of which is configured to be associated with the locking portion. According to claim 16,
the locking part,
A protrusion protruding in a radial direction from the inner base and/or the outer base,
The cell and body fluid collection device for endometrial cancer and ovarian cancer screening test, wherein the unlocking unit is configured to release the lock by pressing the protrusion in a radial direction as it is inserted into the inner base. According to claim 1,
Cells for screening endometrial cancer and ovarian cancer, which are provided on one side of the base and further include a traction part extending to a predetermined length and configured to be pulled to take the collection device out from the vaginal canal, and bodily fluid collection device.

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