KR20230010994A - Multifunctional cosmetic composition containing peat extracts and salts effective for skin wrinkle improvement, whitening, cell regeneration, and wound healing as an active ingredient - Google Patents

Abstract

Provided is a multifunctional cosmetic composition containing a peat extract and salt effective for elasticity improvement, wrinkle improvement, whitening, anti-inflammatory, atopy, cell regeneration, and wound healing of skin as active ingredients comprising: the peat extract which is extracted with water of 65-85 ℃ as an extract solvent; and 5-15 parts by weight of the salt for 100 parts by weight of the peat extract as the active ingredients. The multifunctional cosmetic composition selectively further comprises: one or more ingredients selected from a group consisting of fermented protaetia brevitarsis seulensis larval peptide powder; fermented protaetia brevitarsis seulensis larval oil; a protaetia brevitarsis seulensis larval ethanol extract; and a kamchatka pleurospermum ethanol and acorus calamus ethanol extract.

Description

Multifunctional cosmetic composition containing peat extracts and salts effective for skin wrinkle improvement, whitening, cell regeneration, and wound healing healing as an active ingredient}

The present invention relates to a multifunctional cosmetic composition containing pit extract as an active ingredient and having excellent skin elasticity enhancement, wrinkle improvement, skin whitening, anti-inflammatory, atopy, skin regeneration, and skin wound recovery effects.

Pit is made by rotting dead trees, shrubs, moss, etc. in shallow acidic water and then compressing it with other trees piled on top of it. , The effect of improving cold symptoms of hands and feet by activating blood circulation and metabolism was confirmed, and in particular, it is known to be effective in improving skin elasticity and moisturizing.

In addition, US Patent No. 6267962 (filed on June 30, 1997) treats wounds caused by fungi, bacteria, rickettsia, viral infections, psoriasis, allergies and other dermatitis, eczema, pain, itching, A composition made from peat or the like that can be used for the treatment of inflammation, abnormal cell proliferation or infection is disclosed.

However, despite the various effects of pits as described above, commercialization of cosmetic compositions containing pits as a main component has limitations due to their weak activity.

1. US Patent No. 6267962

Therefore, the problem to be achieved by the present invention is to provide a multifunctional cosmetic composition with excellent skin elasticity enhancement, wrinkle improvement, skin whitening, anti-inflammatory, atopy, skin regeneration, and skin wound recovery by adding a natural substance capable of enhancing its activity to a pit extract. make it a task to do

In order to achieve the above technical problem, the present invention

peat extract extracted with water at 65 to 85° C. as the extraction solvent; and

It provides a multi-functional cosmetic composition comprising 5 to 15 parts by weight of salt as an active ingredient based on 100 parts by weight of the pit extract.

As described above, the multifunctional cosmetic composition according to the present invention is in the group consisting of fermented white-spotted radish larvae peptide powder, fermented white-spotted radish larvae oil, white-spotted radish larvae ethanol extract, Japanese umbrella plant ethanol, and calamus ethanol extract. It further includes any one or more selected ingredients as an active ingredient, and the content is characterized in that 5 parts by weight based on 100 parts by weight of the pit extract.

In the multifunctional cosmetic composition according to the present invention as described above,

The multifunctionality is to show remarkable effects on skin elasticity enhancement, skin whitening, skin wrinkle prevention, antioxidant, anti-inflammatory, anti-atopic, skin regeneration and skin wound healing.

According to the present invention, skin elasticity enhancement, wrinkle improvement, skin whitening, anti-inflammation, atopy, skin regeneration, and skin wound recovery effects are simultaneously enhanced by enhancing the skin activity effect of pits using salt, white-spotted flower larvae, Japanese umbrella grass, and calamus. It is possible to manufacture multi-functional cosmetics that can exert their full potential.

Hereinafter, specific details for carrying out the present invention will be described in detail through examples and test examples.

The present invention is a peat extract extracted with water at 65 to 85 ° C. as an extraction solvent to provide a multifunctional cosmetic composition with excellent skin elasticity enhancement, wrinkle improvement, skin whitening, anti-inflammatory, atopy, skin regeneration, and skin wound recovery effects; And it provides a composition comprising 5 to 15 parts by weight of salt as an active ingredient based on 100 parts by weight of the pit extract.

As described above, the present invention increases the activity of the pit extract on the skin when extracted with water at 65 to 85 ° C instead of hot water at 100 ° C, and dissolves 5 to 15 parts by weight of salt with respect to 100 parts by weight of the pit extract It was completed by confirming that there is a significant effect improvement by synergistic action.

If the content of salt compared to the peat extract is less than 5 parts by weight, synergistic effect does not appear, and if it exceeds 15 parts by weight, there is a problem such as skin irritation and the synergistic effect does not occur, so the meaning of adding is lost.

In addition, the salt is not particularly limited, but it is preferable that it is natural natural salt or self-salt.

also. In the present invention, any one or more components selected from the group consisting of selectively fermented white-spotted flower radish larvae peptide powder, fermented white-spotted flower radish larvae oil, white-spotted flower radish larvae ethanol extract, Japanese umbrella plant ethanol, and calamus ethanol extract It provides a multi-functional cosmetic composition characterized by further comprising as an active ingredient, and it is preferable that they contain 5 parts by weight relative to 100 parts by weight of peat extract, and Japanese umbrella grass and calamus are used by drying the above-ground part from which the roots are removed, The extraction method using ethanol is not particularly limited as long as it is widely known in the art to which the present invention belongs, and means that the white-spotted flower larvae are fasted to remove foreign substances therein, dried, and extracted with ethanol.

In addition, the fermented white-spotted radish larvae peptide powder and the fermented white-spotted radish larvae oil are peptide powders or oils obtained after fermenting the white-spotted radish larvae with lactic acid bacteria. As a substance registered as a cosmetic raw material by , it is also used in the present invention, and a specific manufacturing method is disclosed in Korean Registered Patent No. 10-1938348, the method of which is (a) put slugs or pulverized slugs in water and add Bacillus subtilis var. fermenting by inoculating one or more strains selected from the group consisting of natto strains, Bacillus subtilis strains, and Aspergillus kawachii strains; And (b) separating and obtaining the oil phase of the upper part containing fatty acid oil and the water phase of the lower part containing water-soluble peptide after completion of step (a). Separating fatty oil and water-soluble peptide from slugs, characterized in that It is composed in such a way that

The cosmetic composition of the present invention may include components commonly used in cosmetic compositions, and for example, antioxidants, stabilizers, solubilizers, vitamins, pigments, and flavoring agents, and carriers.

Such a cosmetic composition may be prepared in any formulation conventionally prepared in the art. As a specific example, it may be any one formulation selected from the group consisting of a high-viscosity emulsifier type, a low-viscosity emulsifier type, and a solubilization formulation, but is not limited thereto. Depending on the formulation to be prepared, cosmetic composition ingredients commonly used in the technical field to which the invention pertains may be included. For example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations, packs, massage creams and sprays can be formulated. It may, but is not limited thereto. More specifically, softening lotion, nourishing lotion, nourishing cream, massage cream, essence, eye cream, sun lotion, sun cream, makeup base, BB cream, cleansing cream, cleansing foam, cleansing water, pack, stick product, balm ( Balm) type product, spray or powder formulation.

Depending on the formulation to be prepared, an aqueous phase component, an oil phase component, a surfactant, a moisturizer, a lower alcohol, a thickener, a chelating agent, a preservative, a flavoring agent, etc. may be selected and added.

Hereinafter, the present invention will be described in detail by the following Examples and Experimental Examples. However, the following Examples and Experimental Examples are only to illustrate the present invention, and the content of the present invention is not limited by the following Examples and Experimental Examples.

< Example 1>

6 kg of peat was mixed with 60 liters of purified water heated to 75 ° C, extracted while maintaining 75 ° C for 3 hours to prepare a pit extract, and then dissolved RED SALT from Taehyeon Protection Works made from Taean sun salt to produce according to the present invention A composition was prepared.

Here, the amount of RED SALT used was 10 parts by weight based on 100 parts by weight of the pit extract.

< Example 2>

It is the same as in Example 1, except that it was prepared by further including 5 parts by weight of the ethanol extract of the white-spotted flower larvae based on 100 parts by weight of the pit extract.

< Example 3>

It is the same as Example 1, but there is a difference in that it was prepared by further including 5 parts by weight of the ethanol extract of Japanese umbrella plant relative to 100 parts by weight of the pit extract.

< Example 4>

It is the same as in Example 1, except that the ethanol extract of Calamus was prepared by further including 5 parts by weight based on 100 parts by weight of pit extract.

< Example 5>

It is the same as in Example 1, except that the ethanol extract prepared after mixing the white-spotted flower larvae, Japanese umbrella plant, and calamus in the same weight ratio was prepared by further including 5 parts by weight based on 100 parts by weight of the peat extract. .

< Example 6>

It is the same as in Example 1, except that it was prepared by further including 5 parts by weight of the fermented white-spotted radish larvae peptide powder based on 100 parts by weight of the pit extract.

The fermented white-spotted radish larvae peptide powder was supplied and used from HMO Health Dream Farming Association located in Taean, Chungcheongnam-do.

< Example 7>

It is the same as in Example 1, except that it was prepared by further including 5 parts by weight of fermented white-spotted radish larvae oil based on 100 parts by weight of pit extract.

The fermented white-spotted flower radish larvae oil was supplied and used from HMO Health Dream Farming Association located in Taean, Chungcheongnam-do.

< comparative example 1>

6 kg of peat was mixed with 60 liters of purified water heated to 75° C. and extracted while maintaining the temperature at 75° C. for 3 hours to prepare a composition containing the peat extract as an active ingredient.

< comparative example 2>

6 kg of peat was mixed with 60 L of purified water heated to 100 ° C. and extracted while maintaining 100 ° C. for 3 hours to prepare a composition containing the peat extract as an active ingredient.

< test example One: Elastase Evaluation of skin elasticity enhancement and anti-wrinkle efficacy through inhibitory activity>

After adding 40 μl of a solution of proporcine pancreas elastase (2.5 U/ml) dissolved in 50 mM Tris-HCl buffer (pH 8.6) to 40 μl of the test solution diluted with the compositions of Examples and Comparative Examples in methanol, 50 mM Tris-HCl buffer ( 80 μl of N-succinyl-(L-Ala)3-p-nitroanilide (0.5 mg/ml) dissolved in pH 8.6) was added and mixed. After reacting at 37° C. for 30 minutes, absorbance was measured at 410 nm. As a positive control, oleanolic acid was used.

Elastase inhibitory activity was calculated by the absorbance reduction rate of the sample solution added and unadded as in the following formula, and the results are shown in Table 1.

Calculation formula: Inhibition rate (%) = 1-(absorbance of sample added group/absorbance of sample-free group) x 100

Sample Concentration (100 μg/mL) Example 1 82.3±0.6 Example 2 85.9±0.7 Example 3 86.3±0.6 Example 4 86.2±0.5 Example 5 90.3±0.6 Example 6 91.5±0.4 Example 7 92.6±0.6 Comparative Example 1 55.4±0.6 Comparative Example 2 32.7±0.6 oleanolic acid 70.6±0.5

Elastase present in human neutrophil granulocytes degrades elastin, an insoluble elastic fiber protein of animal connective tissue, and breaks the network structure of the dermal tissue of the skin. In the case of suppression, it is possible to maintain or restore skin elasticity and prevent skin wrinkles. Looking at the results of Table 1 above, all the extracts of the examples of the present invention showed superior effects than the positive control group, and the synergistic effect of salt, etc. It was confirmed, and especially in Examples 5, 6, and 7, very good effects were shown.

In addition, looking at Comparative Example, it was found that extracting pits at a temperature lower than 100 ° C. was effective, as the effect was lower than that of Comparative Example 1 in Comparative Example 2 extracted with hot water.

< test example 2: Evaluation of whitening efficacy>

One) tyrosinase Inhibition activity measurement

0.175M sodium phosphate buffer (pH 6.8) 0.2ml of 10mM L-DOPA and 0.1ml of sample solution were added to 0.5ml of 0.175M sodium phosphate buffer (pH 6.8) in a 96 well plate. DOPA chrome generated in the reaction solution by reacting at ℃ for 2 minutes was measured at 475 nm, and Arbutin was used as a positive control.

Tyrosinase inhibitory activity was calculated by the absorbance reduction rate of the sample solution added and unadded as in the following formula, and the results are shown in Table 2.

Calculation formula: Inhibition rate (%) = 1-(absorbance of sample added group/absorbance of sample-free group) x 100

Sample Concentration (100 μg/ml) Example 1 67.8±0.3 Example 2 76.5±0.5 Example 3 75.9±0.6 Example 4 74.2±0.5 Example 5 81.9±0.6 Example 6 82.7±0.5 Example 7 82.4±0.6 Comparative Example 1 42.5±0.8 Comparative Example 2 29.5±0.8 Arbutin 55.8±0.8

Tyrosinase plays a very important role in the production of melanin in the skin. It is a tyrosine hydroxylase that oxidizes tyrosine in the melanosome to make DOPA. It oxidizes DOPA to make DOPA quinone. , If this is suppressed, the production of melanin is suppressed to exhibit a skin whitening effect. Looking at the results of Table 2, all the extracts of the examples of the present invention showed a superior effect than the positive control group, and the synergistic effect through salt It was confirmed, and in particular, Examples 5, 6, and 7 showed very good effects.

In addition, looking at Comparative Example, it was found that extracting pits at a temperature lower than 100 ° C. was effective, as the effect was lower than that of Comparative Example 1 in Comparative Example 2 extracted with hot water.

2) Measurement of melanin biosynthesis inhibitory activity

B16F10 cells, a melanoma cell line, were purchased from the Korean Cell Line Bank, Dulbecco's modified Eagle's supplemented with 1% antibiotic (Gibco, USA) and 10% fetal bovine serum (FBS; Gibco, Grand Island, USA). It was cultured in a 37°C, 5% CO ₂ incubator using a medium (DMEM) medium, and subculture was performed once every 2 days.

B16F10 cells cultured in DMEM medium were inoculated in a 24 well plate at 2.0 X 10 ⁴ cells/well, and then cultured for 24 hours in a 37°C, 5% CO ₂ incubator and mixed with the sample.

To stimulate the samples and cells, α-MSH, a stimulant, was mixed and added at 200 nM, cultured for 48 hours in an incubator at 37°C, 5% CO ₂ , then the culture medium was removed, and each well was washed with phosphate buffer (pH 7.4). did

Subsequently, 100 μl of 1N NaOH was added to detach the cells, and then transferred to a 1.5 ml tube. After reacting at 80 ℃ for 1 hour, the absorbance was measured at 405 nm with a spectrophotometer, and melanin biosynthesis inhibition was calculated by the absorbance decrease rate of the sample solution added and unadded, and the results are shown in Table 3.

sample Melanin contents (%) α-MSH(-) - α-MSH (+, 200 nm) 100 α-MSH (+, 200 nM) + Example 1 42.8 ± 1.2 α-MSH (+, 200 nM) + Example 2 35.9±1.5 α-MSH (+, 200 nM) + Example 3 35.1 ± 1.1 α-MSH (+, 200 nM) + Example 4 34.5 ± 1.3 α-MSH (+, 200 nM) + Example 5 26.1 ± 1.2 α-MSH (+, 200 nM) + Example 6 24.8 ± 1.1 α-MSH (+, 200 nM) + Example 7 25.1 ± 1.2 α-MSH (+, 200 nM) + Comparative Example 1 66.2 ± 1.3 α-MSH (+, 200 nM) + Comparative Example 2 77.8 ± 1.3

Looking at Table 3, it was confirmed that melanin synthesis was induced by α-MSH through the α-MSH alone treatment group, and all of the example extracts of the present invention showed excellent effects compared to the α-MSH alone treatment group. Significance of the effect, such as synergistic effect, was confirmed, and particularly excellent effects were shown in Examples 5, 6, and 7.

< test example 3: Evaluation of anti-inflammatory efficacy through inhibition of nitric oxide (NO) production>

RAW 264.7 cells, a murine macrophage cell line, were purchased from the Korean Cell Line Bank and were supplemented with 1% antibiotic (Gibco, USA) and 10% fetal bovine serum (FBS; Gibco, Grand Island, USA) from Dulbecco's. It was cultured in a 37°C, 5% CO ₂ incubator using modified Eagle's medium (DMEM) medium, and subculture was performed once every 2 days.

RAW 264.7 cells were placed in a 24 well plate at 2.0 × 10 ⁵ cells/ml using DMEM medium supplemented with 10% FBS and cultured for 18 hours. LPS was mixed with the prepared sample at a concentration of 1 ug/ml and the cells were simultaneously treated. and cultured for 24 hours in a 37°C, 5% CO ₂ incubator.

Subsequently, 100 μl of the cell culture supernatant and 100 μl of Griess reagent were mixed and reacted in a 96 well plate for 10 minutes, and then absorbance was measured at 540 nm.

The amount of NO produced was determined in the form of NO ₂ ^- present in the cell culture medium using Griess reagent [1% (w/v) sulfanilamide, 0.1% (w/v) naphylethylenediamine in 2.5% (v/v) phosphoric acid]. It was measured and confirmed using sodium nitrite (NaNO ₂ ) as a standard. The results are shown in Table 4, and 2-amino-4-methylpyridine, a control group, was used as a positive control.

Sample NO production (%) LPS (-) - LPS (+, 1 μg/ml) 100 2-amino-4-methylpyridine 36.8 ± 1.9 LPS (1 μg/ml) + Example 1 (1000 μg/ml) 29.9 ± 1.3 LPS (1 μg/ml) + Example 2 (1000 μg/ml) 20.7 ± 1.9 LPS (1 μg/ml) + Example 3 (1000 μg/ml) 20.9 ± 1.4 LPS (1 μg/ml) + Example 4 (1000 μg/ml) 20.9 ± 1.2 LPS (1 μg/ml) + Example 5 (1000 μg/ml) 17.1 ± 1.3 LPS (1 μg/ml) + Example 6 (1000 μg/ml) 15.7±1.2 LPS (1 μg/ml) + Example 7 (1000 μg/ml) 16.2 ± 1.3 LPS (1 μg/ml) + Comparative Example 1 (1000 μg/ml) 55.7 ± 1.9 LPS (1 μg/ml) + Comparative Example 2 (1000 μg/ml) 71.2 ± 1.9

Looking at the results of Table 4, all of the extracts of the examples of the present invention showed a superior effect than the positive control group, and it was confirmed that the effect such as the synergistic effect through salt was remarkable, especially in Examples 5, 6, and 7. showed

< Sihimye 4: inflammatory chemokines ( TARC , MDC ) through production inhibition activity anti-atopy Efficacy evaluation>

HaCaT cells, a human keratinocyte cell line, were purchased from the Korean Cell Line Bank and cultured in a 37°C, 5% CO ₂ incubator using Dulbecco's modified Eagle's medium containing 1% antibiotic and 10% fetal bovine serum. Subculture was performed once.

HaCaT cells 3.0 * 10 ⁵ cells / ㎖ was cultured in a 24 well plate for 18 hours before, and IFN-γ and TNF-α were mixed with the prepared sample at a concentration of 10 ng / ㎖, respectively, and the cells were simultaneously treated at 37 ℃, 5% CO ₂ incubator incubated for 24 hours.

Subsequently, the culture medium was transferred to a 1.5 ml tube and centrifuged to measure the amount of chemonkines synthesized in the supernatant obtained. ELISA) kit (R&D Systems), and the r ² value of the standard curve for the standard was 0.99 or more.

Sample TARC production (%) - 0 TNF-α (10ng/ml) + IFN-γ (10ng/ml) 100 TNF-α (10ng/ml) + IFN-γ (10ng/ml) +
Example 1 (1000 μg/ml) 35.1 ± 1.3 TNF-α (10ng/ml) + IFN-γ (10ng/ml) +
Example 2 (1000 μg/ml) 27.9 ± 2.1 TNF-α (10ng/ml) + IFN-γ (10ng/ml) +
Example 3 (1000 μg/ml) 28.3 ± 1.6 TNF-α (10ng/ml) + IFN-γ (10ng/ml) +
Example 4 (1000 μg/ml) 27.6±1.5 TNF-α (10ng/ml) + IFN-γ (10ng/ml) +
Example 5 (1000 μg/ml) 20.4 ± 1.6 TNF-α (10ng/ml) + IFN-γ (10ng/ml) +
Example 6 (1000 μg/ml) 19.5 ± 1.7 TNF-α (10ng/ml) + IFN-γ (10ng/ml) +
Example 7 (1000 μg/ml) 19.6 ± 1.3 TNF-α (10ng/ml) + IFN-γ (10ng/ml) +
Comparative Example 1 (1000 μg/ml) 67.1 ± 1.2 TNF-α (10ng/ml) + IFN-γ (10ng/ml) +
Comparative Example 2 (1000 μg/ml) 79.2 ± 1.2

It is known that the expression of TARC is increased in patients with atopic dermatitis. Looking at the results of Table 5 above, it was confirmed that the expression of TARC was induced through the TNF-α and IFN-γ alone treatment group, and when treated with the sample of Example Compared to the TNF-α and IFN-γ treatment groups, it was confirmed that the expression of TARC was highly inhibited, and in particular, examples 5, 6, and 7 showed excellent effects.

< Sihimye 5: Evaluation of skin cell regeneration and wound healing effects through fibroblast mobility evaluation>

Human dermal fibroblast cells were purchased from the Korea Cell Line Bank and cultured in a 37°C, 5% CO ₂ incubator using Dulbecco's modified Eagle's medium containing 1% antibiotic and 10% fetal bovine serum, and cultured once every 3 or 4 days. Subculture was performed.

To evaluate the mobility of fibroblast, CytoSelect ^TM 24-Well Wound Healing Assay kit (CELL BIOLABS INC. USA) was used. After the wound field inserts were well fixed to each well of a 24-well plate using sterilized forceps, fibroblasts were inoculated into the 24-well plate at 8.0x10 ⁴ cells/well and 3.0x10 ⁵ cells/well, respectively.

After 18 hours of pre-incubation in a 37°C, 5% CO ₂ incubator, samples are prepared by concentration. After removing the wound field insert using sterilized forceps, the culture medium was removed, washed twice with PBS, and then treated with the prepared sample, the composition of Example 1, in each well, and then incubated at 37°C, 5% CO ₂ incubator for 2 hours. After culturing, the culture medium was removed, washed with PBS, and replaced with a culture medium containing no sample.

Then, check the cell status hourly for 24 hours, 48 hours, and 72 hours in a 37℃, 5% CO ₂ incubator, remove the culture medium at the time to stop the culture, and wash twice with PBS so that no cell residue remains. Next, 250 μl of cell stain solution was added to each well, reacted at room temperature for 15 minutes, washed again with PBS three times, and the cell mobility was checked under a microscope with the plate dried at room temperature.

The skin plays a major role in protecting the individual as the primary barrier to the external environment. Fibroblasts produce collagen, which accounts for 70% of the dry weight of the dermal layer in the skin, and is the main cell constituting the dermal layer. In order to regenerate the dermal layer of the damaged skin, the regeneration of fibroblast is the most important, and a wound healing assay was performed to check whether the Example extracts affect wound healing on fibroblast. The untreated control group and Example 1 extract The degree of proliferation of each cell group treated with 6.25 μg/ml was observed and the results are shown in Table 6.

fibroblast sample N.C. hour 48 hours 72 hours

sample Example 1 composition Sigyn 48 hours 72 hours

Looking at Table 6, as a result of culturing for 48 hours and 72 hours, it was observed that the speed of cell migration and proliferation was faster than that of the negative control over time in the cells treated with the extract of Example 1. A significant effect could be confirmed.

As described above, according to the present invention, skin elasticity enhancement, wrinkle improvement, skin whitening, anti-inflammation, atopy, skin regeneration, skin regeneration, and It is possible to manufacture multi-functional cosmetics that can simultaneously exhibit wound healing effects.

Claims (4)

peat extract extracted with water at 65 to 85° C. as the extraction solvent; and
A multifunctional cosmetic composition comprising 5 to 15 parts by weight of salt as an active ingredient based on 100 parts by weight of the pit extract.
According to claim 1,
Further containing as an active ingredient at least one component selected from the group consisting of fermented white-spotted radish larvae peptide powder, fermented white-spotted radish larvae oil, white-spotted radish larvae ethanol extract, Japanese umbrella grass ethanol, and calamus ethanol extract A multifunctional cosmetic composition, characterized in that.
In claim 2,
A multifunctional cosmetic composition, characterized in that 5 parts by weight of at least one component selected from the group consisting of the ethanol extract of the white-spotted flower radish larva, ethanol extract of Japanese umbrella plant, and ethanol extract of calamus is included based on 100 parts by weight of the pit extract.
According to any one of the preceding claims,
A multifunctional cosmetic composition, characterized in that the multifunctionality is skin elasticity enhancement, skin whitening, skin wrinkle prevention, antioxidant, anti-inflammatory, anti-atopic, skin regeneration and skin wound healing.