KR20230005379A - aerosol generating material - Google Patents

Abstract

The present invention relates to an aerosol generating material for inclusion in an aerosol providing system, such as a device for heating an aerosol generating material to volatilize at least one component of the aerosol generating material, the aerosol generating material comprising a volatile component incorporated by injection. and active substances. The present invention also relates to methods for preparing such compositions and apparatus comprising such materials.

Description

aerosol generating material

The present invention relates to an aerosol-generating material for inclusion in an aerosol-generating system, such as a device for heating an aerosol-generating material to volatilize at least one component of the aerosol-generating material, wherein the aerosol-generating material is incorporated by injection with an active material. contains volatile components. The invention also relates to methods for preparing such compositions.

Smoking articles such as cigarettes, cigarettes, cigars, and the like burn the tobacco during use to produce tobacco smoke. Attempts have been made to provide alternatives to these articles by creating products that release compounds without burning. Examples of such products are so-called “heat not burn” products or tobacco heating devices or products that release compounds by heating the smokeable material but not burning it.

It is also known to incorporate flavors into smoking articles to add certain desirable flavors to the aerosol produced by the smoking article. This has been accomplished in a variety of different ways, including the use of crushable capsules containing flavor compositions.

According to a first aspect of the present invention there is provided an aerosol generating material comprising at least one particle comprising an active substance and a volatile component, wherein the volatile component has a vapor pressure at 20°C equal to or greater than the vapor pressure of the active substance at 20°C. The volatile component is incorporated into the aerosol-generating material by injection and the release of the active substance from the aerosol-generating material is controlled by competition with the release of the volatile component.

In some embodiments, the aerosol generating material is for inclusion in an aerosol delivery system.

In some embodiments, the active substance is nicotine.

In some embodiments, the particles comprising the active substance are tobacco particles.

In some embodiments, the vapor pressure of the volatile component is at least 6 Pa at 20°C.

In some embodiments, the volatile component is a volatile flavor. In some embodiments, the volatile component is selected from the group consisting of menthol, limonene, linalool, camphene and eucalyptol.

In some embodiments, the volatile component has no distinctive or characteristic flavor.

In some embodiments, the pH of the aerosol generating material is between about 4 and about 9.5.

In some embodiments, the pH of the aerosol generating material is increased by the addition of one or more bases or a basic buffering system.

In some embodiments, the one or more bases are selected from the group consisting of hydroxides, carbonates and hydrogen carbonates, and optionally, the one or more bases are selected from the group consisting of potassium hydroxide, sodium hydroxide, sodium carbonate, and sodium bicarbonate. do.

In some embodiments, the particles comprising the active material have an average diameter of 3 mm or less, 1 mm or less, 0.5 mm or less, or 0.3 mm or less.

In some embodiments, the aerosol generating material further comprises one or more aerosol formers. In some embodiments, the aerosol former is selected from the group consisting of glycerol, propylene glycol and glyceryl triacetate.

In some embodiments, the aerosol generating material further comprises one or more binders. In some embodiments, the one or more binders are thermoreversible gelling agents, such as gelatin; starches; polysaccharides; pectins; celluloses; cellulose derivatives such as carboxymethylcellulose; and alginates.

In some embodiments, a precursor composition comprising particles comprising an active material is granulated or spheronized to form an agglomerated structure.

In some embodiments, a precursor composition comprising particles comprising an active material is extruded to form an agglomerated structure.

In some embodiments, the aerosol generating material is in the form of granules.

According to a second aspect of the present invention, an aerosol providing system comprising the aerosol generating material according to the first aspect is provided.

In some embodiments, the system is an aerosol generating material heating system that includes an aerosol generating material to be heated to volatilize the components, and optionally includes a filter or filter element.

In some implementations, the system is a hybrid system comprising an aerosol generating material to be heated to volatilize the components, and a liquid to be heated to form vapor, and optionally comprising a filter or filter element.

In some embodiments, the aerosol generating material is composed of one or more particles of the aerosol generating material.

In some embodiments, the aerosol generating material is heated by steam.

In some embodiments, the liquid is a nicotine-free liquid.

In some implementations, the device includes means for heating the liquid to form vapor, but does not include separate means for heating the aerosol generating material.

According to a third aspect of the present invention there is provided a method for preparing an aerosol generating material comprising particles comprising an active substance and a volatile component for use in an aerosol delivery system, the method comprising: forming an agglomerated structure comprising particles and incorporating a volatile component into the agglomerated structure by injection, wherein the volatile component has a vapor pressure at 20° C. equal to or greater than the vapor pressure of the active material at 20° C. has a vapor pressure.

In some embodiments, the aerosol generating material is formed from a precursor composition comprising particles comprising an active material, and the resulting composition is impregnated with a volatile component.

In some embodiments, the precursor composition is granulated or spheronized to form an agglomerated structure.

In some embodiments, the precursor composition is extruded to form an agglomerated structure.

According to a fourth aspect of the present invention there is provided an apparatus for heating an aerosol generating material to volatilize at least one component of the aerosol generating material and a nicotine-free liquid to be heated to form a vapor, comprising: comprises an aerosol generating material according to the first aspect, wherein the aerosol generating material is heated by steam.

In some embodiments, the device includes means for heating the liquid to form vapor, but does not include separate means for heating the aerosol generating material.

In some embodiments, the pH is increased by the addition of one or more bases or a basic buffer system.

According to a fifth aspect of the present invention there is provided a particle comprising by injection a volatile component having a vapor pressure equal to the vapor pressure at 20° C. of the active substance for use in controlling the release of nicotine in an aerosol generating material. or greater vapor pressure at 20°C.

Embodiments of the present invention will now be described, by way of example only, with reference to the accompanying drawings.
1 is a flow diagram illustrating the main steps of a process according to implementations of the present invention.
Figure 2 is a schematic diagram of some extruded granules.
3 is a schematic cross-sectional view of an article for heating an aerosol generating material to volatilize at least one component of the aerosol generating material.
4 is a schematic diagram of a hybrid system for heating an aerosol generating material to volatilize at least one component of the aerosol generating material.
5 is a schematic cross-sectional view of an example of a cartridge containing multiple particles of aerosol generating material.

The present invention relates to an aerosol generating material comprising an active substance and a volatile component added to the composition by injection. The composition may release volatile components and active substances when heated.

In some embodiments, the aerosol generating material is in particulate or monolithic form. In some embodiments, the material is an agglomerated structure. This means that they are agglomerates or clusters formed by fusing or attaching a number of particles to each other.

The aerosol generating material can provide a consistent and prolonged release of the active substance from the aerosol generating material as a result of the presence of a volatile component having a vapor pressure at 20°C equal to or greater than that of the active substance. . While not wishing to be bound by any particular theory, it is believed that the active substance and volatile component compete for volatilization from the aerosol generating material. It is believed that the presence of volatile components that readily volatilize upon heating inhibits volatilization of the active material, thereby slowing the release of the active material from the aerosol generating material. This is in tobacco heating devices and hybrids, where an active substance, such as nicotine, generally volatilizes quickly, providing an initial rapid release of the active ingredient, followed by a rapid drop in nicotine release resulting in inconsistent delivery and user experience. It is particularly advantageous in devices.

Thus, in some embodiments of the invention, the presence of a volatile component controls the release of the active agent(s) from the aerosol generating material. This is an unexpected and highly beneficial effect of the compositions described herein.

volatile components

In some embodiments, the composition includes a volatile component added by injection.

Upon heating the injected aerosol-generating material, volatile components within the porous surface of the material are released and transferred to the aerosol generated by heating the aerosol-generating material.

The aerosol-generating material is doped with a volatile component. In some embodiments, the volatile component is transported during injection and provided to the pores of the particles of the aerosol generating material. The injection process depends on the low vapor pressure and/or high volatility of the volatile components provided in solid or liquid form. Volatile components volatilize from either solid or liquid form. When the aerosol-generating material is in close proximity to the volatile component, the volatilized volatile component is deposited on the surface of the material, particularly in the pores of the material, to form an aerosol-generating material infused with the volatile component.

active substance

An active substance as used herein may be a physiologically active material, which is a material intended to achieve or enhance a physiological response. The active substance may be selected from, for example, nutraceuticals, nootropics and psychoactives. The active substance may be naturally occurring or obtained synthetically. The active substance may include, for example, nicotine, caffeine, taurine, thein, vitamins such as B6 or B12 or C, melatonin, cannabinoids, or constituents, derivatives, or combinations thereof. . The active substance may include one or more constituents, derivatives or extracts of tobacco, cannabis or other plant kingdoms.

In some embodiments, the active substance includes nicotine. In some embodiments, the active agent includes caffeine, melatonin or vitamin B12.

As referred to herein, the active substance may include or be derived from one or more plants or constituents, derivatives or extracts thereof. As used herein, the term "botanical" includes, but is not limited to, extracts, leaves, bark, fibers, stems, roots, seeds, flowers, fruits, pollen, bark, hulls, and the like. It includes any material derived from plants that are not Alternatively, the material may contain active compounds naturally present in botanicals obtained synthetically. The material may be in the form of a liquid, gas, solid, powder, dust, comminuted particles, granules, granules, flakes, strips, sheets, and the like. Exemplary botanicals are tobacco, eucalyptus, star anise, hemp, cocoa, cannabis, fennel, lemongrass, peppermint, spearmint, rooibos, chamomile, flax, ginger, ginkgo, hazelnut, hibiscus, bay, licorice, matcha, orange skin, Papaya, rose, sage, tea such as green or black tea, thyme, cloves, cinnamon, coffee, aniseed, basil, bay leaf, cardamom, coriander, cumin, nutmeg, oregano, paprika, rosemary, saffron, lavender , lemon peel, mint, juniper, elderflower, vanilla, winter green, lobules, turmeric, turmeric, sandalwood, cilantro, bergamot, orange blossom, myrtle, cassis, valerian, pimento, mace, damian, marjoram, olive, lemon chestnut, lemon basil, chive, carbi, verbena, tarragon, geranium, mulberry, ginseng, theanine, theacrine, maca, ashwagandha, damiana, guarana, chlorophyll, baobab or any combination thereof. Mint can be selected from the following mint cultivars: Mentha arvensis, Mentha c.v., Mentha niliaca, Mentha piperita, Mentha piperita citrata c.v., Mentha piperita c.v., Mentha spicata crispa, Mentha cordifolia, Mentha longifolia, Mentha suaveolens variegata, Mentha pulegium, Mentha spicata c.v. and Mentha suaveolens.

In some embodiments, the active substance comprises or is derived from one or more botanicals or components, derivatives or extracts thereof, and the botanical is tobacco.

In some embodiments, the active substance comprises or is derived from one or more botanicals or components, derivatives or extracts thereof, the botanical being selected from eucalyptus, star anise, cocoa and hemp.

In some embodiments, the active substance comprises or is derived from one or more plants or components, derivatives or extracts thereof, and the botanical is selected from rooibos and fennel.

particles of active substance

In some embodiments, the aerosol generating material comprises a particle or particles comprising an active substance. Herein, particles of active material are also referred to as “active particles”.

In some embodiments, the active substance is a plant-derived active substance. In such embodiments, the particles of active material may be plant particles comprising the active material. Alternatively, the particles of active material may comprise active material deposited in or on particles of carrier material.

In some embodiments, the active substance is nicotine. The nicotine particles may be particles of tobacco material. Alternatively, the nicotine particles may include a carrier material and nicotine.

In some embodiments, the particles comprising the active substance present in the aerosol generating material are used to ensure that a number of such particles can be aggregated to form an aerosol-providing system having desired dimensions based on their intended use. has a size small enough for

Smaller particles of active material have a higher surface area to volume ratio, and thus they may exhibit improved release of active material compared to particles of larger sizes.

Additionally, the size of the active particles (and of other particles in the precursor composition) will affect the porosity and density of the aerosol generating material and agglomerated structures. Accordingly, the size of the active particles can be selected to create a more porous, agglomerated structure, which will affect the release of the active material. Thus, the size of the active particles is another factor that can be tuned to affect the release of the active substance, particularly where the aerosol generating material has an agglomerated structure made by granulation, as opposed to extrusion.

The preferred size of the active particles may also depend on the method used to form the agglomerated structures. For example, extrusion processes can be sensitive to the size of the particles in the composition being extruded. Specifically, in some embodiments in which the precursor composition is extruded to form an agglomerated structure, the particles of the precursor composition comprising active particles, such as tobacco particles, as measured by sieving, are about 3 mm or less, It may be desirable to have an average particle size of 1 mm or less, about 0.5 mm or less, or about 0.3 mm or less.

In some embodiments, the active particles of the precursor composition and/or aerosol generating material have an average particle size of about 3 mm or less, 1 mm or less, or about 0.5 mm or less, or about 0.3 mm or less, as measured by sieving. It may be desirable to have an average particle size of In some embodiments, the average particle size is in the range of about 0.1 to about 3 mm, about 0.1 to about 1 mm, about 0.1 to about 0.5 mm, about 0.1 to about 0.4 mm, or in the range of about 0.2 to about 0.3 mm. to be. In some embodiments, at least about 90% of the particles of the precursor composition will have a particle size within the range of about 0.1 to about 3 mm, or about 0.1 to about 1 m, or about 0.1 to about 0.5 mm. In some embodiments, at least about 90% of the active particles of the precursor composition will have a particle size within the range of about 0.1 to about 3 mm, or about 0.1 to about 1 mm, or about 0.1 to 0.5 mm. In some embodiments, none of the particles in the precursor composition have a particle size greater than 5 mm, greater than 4 mm, greater than 2 mm, greater than 1.5 mm, or greater than about 1 mm.

In some embodiments, the active particles are particles of plant material. When the active substance is or comprises nicotine, the active particles may be particles of tobacco material (referred to herein as tobacco particles).

Particles of a desired size can be formed by grinding, crushing, cutting or crushing plant material, such as tobacco material. Suitable machinery for producing such plant particles is, for example, shredders, cutters, or mills, such as hammer mills, roller mills or Other types include commercially available milling machines. The size of the plant particles can be readily manufactured from a variety of different types of plant material, formed into agglomerated structures using the processes described herein and having the properties described herein, and are readily released. selected to provide particles that provide a source of active substances.

Without wishing to be bound by any one particular theory, it is believed that the chopping of tobacco to form tobacco particles enhances the release of nicotine, as well as tobacco constituents, including volatile flavors and aromatic constituents. guessed The increased surface area of the tobacco particles is also believed to aid volatilization. Smaller tobacco particles also improve the homogeneity of the agglomerated structures formed therefrom along with other ingredients.

Tobacco material used to form the tobacco particles may include tobacco lamina, stem, stalk, ribs, scraps and shorts or two of these. It may be any type of tobacco and any part of the tobacco plant, including mixtures of one or more. Suitable tobacco materials include the following types: Virginia or flue-cured tobacco, Burley tobacco, Oriental tobacco, or tobacco optionally including those listed herein. A blend of ingredients. Tobacco can be expanded, such as dry-ice expanded tobacco (DIET), or processed by any other means. In some embodiments, the tobacco material can be reconstituted tobacco material. Tobacco may or may not be pre-processed, such as solid stems (SS); shredded dried stems (SDS); steam treated stems (STS); or any combination thereof. The tobacco material may be fermented, cured, uncured, toasted, or otherwise pretreated.

pH control

In some embodiments, the aerosol generating material is formed from a precursor composition comprising active particles, wherein the pH of the active particles has been adjusted to a basic pH. For example, the pH may be adjusted to at least about 7.5. pH can be adjusted by the addition of one or more bases. Alternatively, pH may be adjusted by use of a buffer solution. In some embodiments, the active substance in the pH-adjusted material is nicotine.

In some embodiments, the aerosol generating material comprises the active particles and one or more bases or a basic buffer system such that the nicotine particles have a basic pH. For example, the pH may be at least about 7.5.

The purpose of adjusting the pH of the active particles and/or precursor composition is to provide the active substances in chemical form that are readily released from the aerosol generating material and/or that they are readily delivered to the aerosol generated by the smoking article. .

In some embodiments, the pH of the active particles is adjusted to at least about 7.5, at least about 8, at least about 8.5, at least about 9, at least about 9.5 or at least about 10. In some embodiments, the pH is adjusted to about 14 or less, about 13.5 or less, about 13 or less, about 12.5 or less, about 12 or less, about 11.5 or less, about 11 or less, about 10.5 or less, or about 10 or less. In some embodiments, the pH of the active particles is adjusted to about 8 to about 10, or about 8.5 to about 9.5.

In some embodiments, the pH of the aerosol generating material is at least about 7.5, at least about 8, at least about 8.5, at least about 9, at least about 9.5 or at least about 10. In some embodiments, the pH is about 14 or less, about 13.5 or less, about 13 or less, about 12.5 or less, about 12 or less, about 11.5 or less, about 11 or less, about 10.5 or less, or about 10 or less. In some embodiments, the pH of the aerosol generating material is adjusted to between about 8 and about 10, or between about 8.5 and about 9.5.

In some embodiments, the pH of the aerosol generating material is adjusted to about 7.5 to about 10, or about 8 to about 9, or about 8.5, about 9, about 9.5, or about 10.

In some embodiments, the base used to adjust the pH is a hydroxide or carbonate. The hydroxides used may be monoacidic bases, diacidic bases or triacidic bases. Suitable bases include, for example, potassium hydroxide, calcium hydroxide, silver hydroxide, ammonium hydroxide, magnesium hydroxide, sodium carbonate, sodium bicarbonate, hydrogen bicarbonate (also known as sodium hydrogen carbonate), and potassium carbonate.

The base may be added in the form of a liquid, such as an aqueous or non-aqueous solution or suspension, or in the form of a solid, such as a powder.

In some embodiments, the pH of the particles comprising the volatile component is not adjusted.

In some embodiments, the aerosol generating material is formed from a precursor composition comprising a mixture of particles comprising an active substance. In some embodiments, the precursor composition further includes a pH adjusting agent. In embodiments where the active particles and pH adjuster are dry, e.g., the base is in the form of a dry powder, the pH of the precursor composition will be adjusted when water is added to the composition (compared to the pH of the particles without the pH adjuster). ).

As used herein, the pH of a precursor composition or aerosol generating material refers to the pH when water is added to the composition in a dry state.

In some embodiments, the buffer system used to adjust pH is a mixture of a weak base and its conjugate acid. Suitable buffer systems include, for example, those having a pH of at least about 7.5, at least about 8, at least about 8.5 or at least about 9. In some embodiments, the pH of the buffer system is between about 8 and about 10, or between about 8.5 and about 9.5. Suitable buffer systems include, for example, those based on ammonia, carbonates or hydroxides with suitable counterions. An example of a specific buffer system is a mixture of ammonia and ammonium chloride.

Additional Ingredients of the Aerosol Generating Material

In some embodiments, the aerosol generating material having an agglomerated structure is formed from a precursor composition comprising active particles.

In some embodiments, the precursor composition and/or aerosol generating material does not include a binder or binder additive. In other embodiments, the precursor composition includes a binder or binding additive. Binding additives may be selected to aid in the formation of an agglomerated structure by helping the particles adhere to each other and to other components in the composition. Suitable binding additives include, for example, thermoreversible gelling agents such as gelatin, starches, polysaccharides, pectins, alginates, wood pulp, celluloses, and cellulose derivatives such as carboxymethylcellulose.

In some embodiments, the precursor composition and/or aerosol generating material further comprises a diluent. Diluents may be in solid or liquid form. In some embodiments, the diluent is inert or substantially inert.

In some embodiments, an agglomerated structure formed from a precursor composition can have an increased surface area by including particles of an inert filler material in the precursor composition. Suitable inert fillers may be porous or non-porous.

In some embodiments, the precursor composition and/or aerosol generating material further comprises at least one aerosol former, which can be, for example, a polyol aerosol generating agent or a non-polyol aerosol generating agent, preferably a non-polyol aerosol generating agent. include It can be solid or liquid at room temperature, but is preferably liquid at room temperature. Suitable polyols include sorbitol, glycerol, and glycols such as propylene glycol or triethylene glycol. Suitable non-polyols include monohydric alcohols, high boiling hydrocarbons, acids such as lactic acid, and esters such as diacetin, triacetin, triethyl citrate or isopropyl myristate. Combinations of aerosol formers may be used in equal or different proportions. Glycerol and propylene glycol may be particularly preferred.

In some embodiments, the precursor composition and/or aerosol generating material may include a flavor-modifying agent to modify or add flavor to the flavor provided by the active particles. In some embodiments, a flavor-modifying agent may be included in the precursor composition. Alternatively or additionally, flavor-modifiers may be added or applied to the aggregated structure. As used herein, the terms "flavour" and "flavourant" refer to a desired taste, aroma ( aroma) or other materials that can be used to create somatosensory sensations. These include naturally occurring flavor ingredients, botanicals, extracts of botanicals, ingredients obtained synthetically, or combinations thereof (eg, tobacco, cannabis, licorice, hydrangea, eugenol, Japanese white bark magnolia leaf). , Chamomile, Fenugreek, Cloves, Maple, Matcha, Menthol, Japanese Mint, Aniseed, Cinnamon, Turmeric, Indian Spices, Asian Spices, Herbs, Wintergreen, Cherry, Berry, Red Berry, Cranberry, Peach, Apple , Orange, Mango, Clementine, Lemon, Lime, Tropical Fruit, Papaya, Rhubarb, Grape, Durian, Dragon Fruit, Cucumber, Blueberry, Mulberry, Citrus, Dramv, Bourbon, Scotch, Whiskey, Gin, Tequila, Rum, Spearmint , Peppermint, Lavender, Aloe Vera, Cardamom, Celery, Cascarilla, Nutmeg, Sandalwood, Bergamot, Geranium, Kat, Naswar, Betel Nut, Shisha, Pine, Honey Essence, Rose Oil, Vanilla, Lemon Oil, Orange Oils, orange blossom, cherry, cassia, caraway, cognac, jasmine, ylang-ylang, sage, fennel, wasabi, chilli, ginger, coriander, coffee, hemp, mint oil from any species of the genus mint, eucalyptus, star anise , cocoa, lemongrass, rooibos, flax, ginkgo biloba, hazel, hibiscus, laurel, mate, orange skin, rose, tea like green or black tea, thyme, juniper, elderflower, basil, bay leaves, cumin, oregano, paprika , rosemary, saffron, lemon peel, mint, lobules, turmeric, coriander, myrtle, cassis, valerian, pimento, mace, damian, marjoram, olive, lemon balm, lemon basil, chive, carbi, verbena, tarragon, limonene , thymol, camphene), flavor enhancers, bitter receptor site blockers, sensory receptor site activators or stimulants, sugars and/or sugar substitutes (e.g. sucralose, acesulfame potassium, aspartame, saccharin, cicl lamates, lactose, sucrose, glucose, fructose, sorbitol or mannitol), and other additives such as charcoal, chlorophyll, minerals, botanicals or breath fresheners. all. “Flavor” and “flavoring agent” may be imitation, synthetic or natural ingredients or blends thereof. “Flavor” and “flavoring agent” may be in any suitable form, eg, a liquid such as an oil, a solid such as a powder, or a gas.

In some embodiments, the flavor includes menthol, spearmint and/or peppermint. In some embodiments, the flavor includes flavor components of cucumber, blueberry, citrus and/or redberry. In some embodiments, the flavor includes eugenol. In some embodiments, the flavor comprises flavor components extracted from tobacco. In some embodiments, the flavor includes flavor components extracted from cannabis.

In some embodiments, a flavor is a sensate intended to achieve a somatosensory sensation that is generally chemically induced and perceived by stimulation of the 5th cranial nerve (trigeminal nerve) in addition to or instead of flavor or taste nerves. ), which may include agents that provide a sensation of heat, sensation of coolness, tingling, or numbness. A suitable thermogenic agent may be, but is not limited to, vanillyl ethyl ether, and a suitable cooling agent may be, but is not limited to, Eucolyptol, WS-3.

In some embodiments, the precursor composition and/or aerosol generating material further comprises a preservative. Suitable preservatives will be readily known to those skilled in the art and will include, for example, those that are safe for use in products that produce inhalable aerosols. Examples of preservatives that may be used are propylene glycol, carvacrol, thymol, L-menthol, 1,8-cineol, phenoxyethanol, phytoside, sorbic acid and salts thereof, sodium hydroxymethylglycinate, ethylhexyl glycerin, parabens, and vitamins such as vitamin E or vitamin C.

In some embodiments, neither the precursor composition nor the aerosol generating material includes a gelling agent.

Shapes of Aggregated Structures

In some embodiments, the aerosol generating material is in particulate form and is small discrete particles. In most embodiments, multiple particles will be included in the device to have a desired effect on the aerosol of the device.

In some embodiments, the particulate aerosol generating material has an average size (as measured by sieving) of about 0.5 mm to about 4 mm. In some embodiments, it may be desirable for the granules to have an average size of about 0.7 mm to about 3 mm.

In other embodiments, the aerosol generating material is in monolithic form, which is larger articles. In most embodiments, a single monolithic component will be included in the device to have the desired effect on the aerosol of the device.

In some implementations, the monolithic components are approximately spherical or cylindrical in shape. They may have a diameter of about 4 mm to about 10 mm. In some embodiments, the diameter can be between about 5 mm and about 8 mm. Additionally, the cylindrical components may have a length of about 5 mm to about 80 mm, about 15 mm to about 50 mm, or about 20 mm to about 30 mm.

formation of aggregated structures

1 is a flow diagram illustrating key steps in the processes of some implementations of the invention. Tobacco starting material, which may be pre-treated or pre-processed, is ground to the desired particle size. The pH is optionally adjusted by adding one or more bases or by adding a buffer solution to the tobacco particles. Optional additional ingredients may be added to the precursor material. These additional ingredients may be in liquid form or in solid form. The additional solid ingredients are preferably in particulate or powder form. Additional ingredients may be added before, during, or after the pH adjustment step. An agglomerated structure is then formed from the resulting precursor composition by adhering the pH-adjusted tobacco particles and optional other ingredients to form multi-particle entities.

In some embodiments, water can be added to the precursor composition as a processing aid. For example, the presence of water can help dissolve components of the precursor composition, such as pH modifiers and sugars, and/or water can aid binding or improve aggregation.

In some embodiments, an agglomerated structure may be formed from a precursor composition by a process comprising one or more steps selected from the group consisting of granulation, extrusion and spheronization.

After formation of the particles of the nicotine delivery composition, the volatile component is added to the particles by injection.

granulation

Granulation of the precursor composition includes binding or fusing the particles of the precursor composition together to form larger multi-particulate entities, referred to herein as agglomerated structures. Multi-particulate entities formed by granulation are referred to as granules, and they may have a variety of geometries, including general shapes such as spheres, cylinders, and the like.

In one embodiment, the granulation step used is wet granulation. In wet granulation, granules are formed by adding a granulating liquid onto a powder bed. Agitation in the system, along with wetting of the components within the precursor composition, results in agglomeration of the particles to produce wet granules. The granulating liquid may be at least partially removed by drying to provide dry granules. The granulation liquid may be water-based or solvent-based. Suitable granulating liquids include, for example, water, glycerol, ethanol and isopropanol alone or in combination. In some embodiments, the granulating liquid includes an aerosol former, such as glycerol or one of the other agents mentioned herein, and/or a binder or binding agent. In some embodiments, no water is added to the precursor composition to aid granulation.

In another embodiment, the granulation step used is dry granulation. In dry granulation, granules are formed without using a granulating liquid. This type of process has the advantage that it does not expose the precursor composition to moisture and, therefore, does not need to expose the granules to heat to dry them. Forming the granules by dry granulation involves compacting and densifying the precursor composition, usually under high pressure.

extrusion

Extruding the precursor composition includes feeding the precursor composition through an orifice to create an extruded agglomerate. The process of pressurizing the precursor composition with shear forces results in agglomerated structures.

Extrusion can be performed using one of the main classes of extruders: screw, sieve and basket, roll, ram and pin barrel extruders. . Single screw or twin screw extruders may be used. Forming the aerosol generating material by extrusion has the advantage that this processing combines mixing, conditioning, homogenization and shaping of the precursor composition.

In some embodiments, during extrusion, the free-flowing precursor composition is exposed to elevated pressure and temperature and passed through an orifice, such as a forming nozzle or die, to form extruded agglomerates. In some embodiments, the extruded agglomerate has a rod-like shape, and/or the extruded agglomerate can be cut into segments of a desired length as it exits the orifice. The rod-shaped extruded agglomerates can then be cut into segments of desired length.

In some embodiments, the precursor composition is exposed to temperatures in the extruder from about 40°C to about 150°C, or from about 80°C to about 130°C, or from about 60°C to about 95°C. In some embodiments, including those using dual extrusion, the precursor composition is exposed to temperatures of about 70°C to about 95°C in the extruder. In some embodiments, including those using single extrusion, the precursor composition is exposed to temperatures of about 60° C. to about 80° C. in the extruder. The composition may be exposed to pressures (immediately before the die or nozzle) ranging from about 2 bar to about 100 bar, or from about 5 bar to about 60 bar, depending on the design of the die or nozzle used.

In some embodiments, where the active particles are particles of plant material, such as tobacco, due to the relatively high density of the extruded agglomerates and the relatively open surface of the plant particles within the agglomerates, the aerosol generating material formed from the extruded agglomerates is Including good heat transfer and mass transfer, which positively affects the release of active substances and volatile components.

In some embodiments, extrusion may be a generally dry process, wherein the precursor composition may optionally include other particulate materials, such as bases, diluents, solid aerosol formers, solid flavor modifiers, and the like, in addition to the active particles. It is a dry or substantially dry material comprising

In some embodiments, liquids may be added to the precursor composition during the extrusion process. For example, water may be added to the precursor composition as a processing aid, eg, to aid in dissolution or solubilization of the components of the composition, or to aid in binding or aggregation. Alternatively or additionally, wetting agents may be added to the precursor composition. In some embodiments, the liquid volatile component can be added to the precursor composition as a liquid component. This may be in addition to or in lieu of applying a liquid volatile component to the agglomerated structures once they are formed (as shown in Figure 1).

In some embodiments, the liquid added to the precursor composition can be an aerosol former, such as glycerol or others discussed herein. When a liquid is added to the precursor composition in this way, the liquid is not only applied onto the surface, but as a result of the extruder pressure combined with intensive mixing by high shear forces, the extruded agglomerate is impregnated with the liquid. When the liquid is an aerosol former, this can result in high availability of the aerosol former in the agglomerated product, enhancing evaporation and release of the active substance and other volatile components from the agglomerated structure. This same integration or impregnation of the agglomerated structure can be achieved when the liquid volatile component is added to the precursor composition and extruded together with other components, such as the active particles.

In some embodiments, given impregnation of the extruded agglomerates with an aerosol former, a larger volume of this additive may be included in the aerosol generating material than if the aerosol former were simply applied to the surface of the precursor composition or extruded agglomerates. In some embodiments, the amount of aerosol former included in the aerosol generating material is at least about 1%, at least about 1.5%, at least about 2%, at least about 3%, at least about 5%, at least about 10% by weight. %, at least about 15% or at least about 20%. In some embodiments, the amount of aerosol former included in the aerosol generating material can be up to about 30% by weight and even up to about 40% by weight. Higher amounts of aerosol former, such as at least about 10% by weight or at least about 20% by weight, may be advantageous if the aerosol generating material generates an aerosol in addition to releasing the active agent(s) and volatile components. If the primary function of the aerosol generating material is to release the active substance(s) and volatile constituents carried by the material into the existing aerosol or airflow, smaller amounts of aerosol former, such as up to about 5% by weight, may suffice. can

The extruded agglomerates will be shaped by a nozzle or die through which they are passed. In some embodiments, the extruded agglomerate is cut into pieces of desired length. The pieces formed in this way can be used as an aerosol generating material, or they can undergo further processing.

In some embodiments, the nozzle or die is shaped to provide a solid strand of extruded agglomerate. For example, an extruded agglomerate may have the form of a solid cylindrical rod. Alternatively, the extruded agglomerates may have different cross-sectional shapes including elliptical, polygonal (eg, triangular, square, etc.) and star shapes.

In some embodiments, the extruded composition is formed into a desired shape selected to enhance or accelerate the release of the active agent and volatile components, such as by providing a shape having a high surface area per unit volume. Such a large surface area can be provided on the outer surface of the extruded agglomerate, for example by selecting cross-sectional shapes with a large perimeter. Alternatively or additionally, high surface area can be provided through the creation of channels in the extruded agglomerates.

In some embodiments, the nozzle is shaped to provide an extruded agglomerate with internal channels. These inner channels can provide additional surface area and enhance active and volatile component release.

Aerosol generating materials formed from these shaped extruded agglomerate sections have advantageous adjustable strand ventilation properties and internal channel structures with significantly enlarged internal surfaces leading to improved heat and mass transfer. As a result, such shaped compositions exhibit better and more uniform release of active substances and flavors by evaporation. In addition, the structure with internal channels exhibits significantly improved strength in both the radial and axial directions, which is beneficial for further processing of the extruded agglomerate, for example when the extruded agglomerate is cut into segments.

Different nozzle or die designs and/or different process parameters in the extruder, including temperature, pressure and shear forces, can produce different aerosols, including different heat transfer properties, draft resistance, and/or Alternatively, extruded agglomerates can be prepared with different physical properties that can modify the aerosol drawn through the extruded agglomerates.

In some embodiments, the extruded agglomerates are shaped upon release from the extruder. In some embodiments, the extruded agglomerate is cut to an initial length, such as 1 meter, allowed to cool, and then cut into sections of the desired length to provide the nicotine delivery composition in the form of particles of the desired dimensions.

In some embodiments, the extruded agglomerate may be cooled just before it leaves the extruder or as it leaves the extruder. In some embodiments, the cooling is intensive, extruded agglomerates that would be at an elevated temperature, such as about 30°C to about 100°C, or about 40°C to about 70°C, from about 0°C to about 70°C, from about 0°C to about 0°C. exposure to a cooling means that will reduce the temperature to within the range of about 50°C, about 5°C to about 25°C or about 5°C to about 15°C. This rapid cooling of the extruded agglomerates can improve the internal and external stability of the extruded agglomerates. In some implementations, it is the nozzle or die that is cooled to achieve this effect.

In some embodiments, it may be desirable to control the temperature of the precursor composition during extrusion, including prior to feeding the composition through a nozzle or die. This is especially the case when the precursor composition comprises temperature sensitive components, such as volatile components or aerosol formers, such as glycerol. Thus, in some embodiments, extruding the precursor composition includes reducing the temperature of the precursor composition before the precursor composition reaches the nozzle or die. Such cooling of the precursor composition can result in the formation of extruded agglomerates with advantageous properties or can improve the strand-forming process, for example, in which channels must be formed in the extruded agglomerate strands.

In some embodiments, spheronization is used to further process the extruded segments. These segments are typically cylindrical in shape and are cut or divided into uniform lengths after extrusion. Afterwards, the segments are progressively deformed into spherical shapes by spheronization. This shaping occurs as a result of plastic deformation, and spheronization can often result in spherical, agglomerated structures of nearly uniform diameter.

After forming the particles of the nicotine delivery composition, a volatile component is added to the particles by injection. In some embodiments, the volatile component is provided in solid or liquid form. The low vapor pressure and high volatility of the volatile component allows the volatile component to migrate from the solid or liquid and deposit on the surface of the particles. In particular, volatile components may be present in the pores on and within the particles.

Addition of volatile components

After formation of agglomerated particles, a volatile component is added by injection.

In some embodiments, the injection process includes the addition/inclusion of a volatile component (either in solid form and with a specified PSD or in liquid form) into a sealed container containing particles of an aerosol generating material. Contents are stored in sealed containers for specified periods in a controlled environment.

In some embodiments, the volatile component is menthol and solid particles of menthol are used for infusion. The agglomerated structure formed of nicotine particles, such as tobacco particles, is placed in a container with particles of menthol. The container is sealed and maintained at a constant temperature and humidity for a predetermined period of time. During this period, menthol volatilizes and is adsorbed into the pores of the aggregated structure. Eventually, an equilibrium will be reached and the amount of volatile components present in and out of the agglomerated structures will remain constant. At this point, further implantation of aggregated structures is not worthwhile. To enhance volatilization of volatile components, mild heating may be helpful.

A similar process can be carried out with alternative volatile components and/or alternative active materials having the required volatility and vapor pressure and/or volatile components in liquid form. When the volatile component is used in liquid form, as well as injection, the volatile component in liquid form may be slightly adsorbed.

inclusion into the device

One or more particles of aerosol generating material may be included in an aerosol providing system, such as a device for heating the aerosol generating material to volatilize at least one component of the aerosol generating material. The aerosol generating material may include, consist essentially of, or consist of an aerosol generating material as described herein. In some embodiments, the aerosol generating material used in the aerosol providing system further comprises one or more other aerosol generating materials, such as tobacco material.

As used herein, an aerosol-provisioning system is a combination of non-combustible aerosol-provisioning systems, such as tobacco heating products, and aerosol-generating material that release compounds from the aerosol-generating material without burning the aerosol-generating material. It includes hybrid systems that generate aerosols using

In accordance with the present disclosure, a “non-combustible” aerosol-delivery system is one in which an aerosol-generating material that is a component of the aerosol-delivery system (or components thereof) is combusted or burned to facilitate delivery of at least one substance to a user. it does not support

In some embodiments, the delivery system is a non-combustible aerosol delivery system, such as a powered non-combustible aerosol delivery system.

In some embodiments, the non-combustible aerosol delivery system is an electronic cigarette, also known as a vaping device or electronic nicotine delivery system (END), although it is noted that the presence of nicotine in the aerosolizable material is not a requirement. .

In some embodiments, the non-combustible aerosol providing system is an aerosol generating material heating system, also known as a heat-not-burn system. An example of such a system is a tobacco heating system.

In some embodiments, the non-combustible aerosol-provisioning system is a hybrid system for generating an aerosol using a combination of aerosol-generating materials, one or a plurality of which may be heated. Each of the aerosol generating materials may be in the form of a solid, liquid or gel, for example, and may or may not contain nicotine. In some embodiments, the hybrid system includes a liquid or gel aerosol generating material and a solid aerosol generating material. Solid aerosol generating materials may include, for example, tobacco or non-tobacco products.

Typically, a non-combustible aerosol-providing system may include a non-combustible aerosol-providing device and consumables for use with the non-combustible aerosol-providing device.

In some implementations, the present disclosure relates to consumables comprising an aerosol generating material and configured for use with non-combustible aerosol providing devices. These consumables are sometimes referred to as articles throughout this disclosure.

In some implementations, a non-combustible aerosol-providing system, such as its non-combustible aerosol-providing device, can include a power source and a controller. The power source may be an electric power source or an exothermic power source. In some implementations, the exothermic power source can include a carbon substrate that can be energized to distribute power in the form of heat to an aerosol generating material or heat transfer material proximate to the exothermic power source.

In some embodiments, a non-combustible aerosol delivery system can include an area for containing consumables, an aerosol generating agent, an aerosol generating area, a housing, a mouthpiece, a filter, and/or an aerosol-modifying agent.

In some embodiments, a consumable for use with a combustible aerosol providing device includes an aerosol generating material, an aerosol generating material storage area, an aerosol generating material delivery component, an aerosol generating agent, an aerosol generating area, a housing, a wrapper, a filter, a mouthpiece. and/or an aerosol modifier.

The aerosol-generating material may be positioned within the apparatus or device such that the active substances and volatile components released are entrained in the aerosol generated by the apparatus or device upon use and modify the properties of the aerosol. Additionally or alternatively, the aerosol-generating material itself may generate an aerosol during use, the aerosol comprising the released active substance and volatile components.

According to some embodiments, one or more particles of aerosol generating material are included in an aerosol providing system to volatilize components of the aerosol generating material by heating but not burning the material (ie, a tobacco heated product or so-called non-combustible product). . In some of these products, the aerosol generating material is heated to create an aerosol.

In some embodiments, one or more particles of aerosol generating material are heated by these products. In some embodiments, one or more particles of aerosol generating material may be included in the tobacco material to form the material to be heated. For example, one or more particles of an aerosol generating material may be dispersed within a tobacco material, such as cut tobacco or reconstituted tobacco, to contribute to the active substances and flavor imparted by the tobacco. In other embodiments, the tobacco contained in the material to be heated by the aerosol generating material heating system consists of or consists essentially of one or more particles of the aerosol generating material. The aerosol generating material may be directly heated. If there are multiple particles of aerosol generating material, they may be held in a container or cartridge. At least portions of the container or cartridge may be permeable to air to allow air to flow over or through the particles of the aerosol generating material.

3 shows a cross-sectional view of an example of a tobacco heating article for heating an aerosol generating material. Device 11 has a heating chamber 14, which contains an aerosol generating material to be heated and volatilized in use. In this embodiment, the aerosol-generating material is in the form of a monolithic nicotine delivery composition 13 . However, the aerosol generating material may be a plurality of particles of aerosol generating material provided in a cartridge such as illustrated in FIG. 5 or held in a heating chamber.

Device 11 of FIG. 3 further has electronics/power chamber 16 which may include, for example, electrical control circuitry and/or a power source (not shown). The electrical control circuitry may include a controller, such as a microprocessor arrangement, constructed and arranged to control heating of the aerosol generating material via a heating element (not shown). The electrical control circuitry may receive a signal from a puff-actuated sensor that is sensitive to changes in air flow rate or pressure that occur in use, such as upon initiation of suction of device 11 by a user. The electrical control circuitry may then operate to cause heating of the aerosol generating material “on demand”. A variety of arrangements are available for puff-actuated sensors including, for example, thermistors, electro-mechanical devices, mechanical devices, optical devices, opto-mechanical devices and micro electro mechanical systems (MEMS) based sensors. Alternatively, the device may have a manually operable switch for the user to initiate a puff.

Heating chamber 14 is contained within housing 12 . For example, there may be supports and/or insulating means (not shown) positioned between the heating chamber 14 and the housing 12 to help insulate the housing 12 from the heating chamber 14, The housing 12 does not get hot, or at least not too hot to the touch, during use.

The housing 12 includes an inlet 15 through which air is drawn into the device. The housing 12 also includes an outlet 17 on the mouthpiece 18 of the device 11 . Air is drawn into the device 11 through the inlet 15, travels through the device picking up the active substance and other volatile components released by the aerosol generating material 13, and the result produced by the device 11 The negative aerosol exits the device 11 through the outlet 19 and is inhaled by the user.

According to some embodiments, one or more particles of aerosol generating material are included in a so-called hybrid product for heating the aerosol generating material to volatilize at least one component of the aerosol generating material. In some of these products, in addition to heating a liquid, such as a nicotine-free liquid or a nicotine-containing liquid, which is heated by a heat source to form an aerosol or vapor, the aerosol-generating material is heated to create an aerosol. In some hybrid products, an aerosol or vapor formed from a liquid is drawn over or through the aerosol generating material, picking up the active agent(s) and other volatilized ingredients. In other embodiments, the aerosol or vapor formed from the liquid is not drawn over or through the aerosol generating material.

In some implementations of the hybrid systems, the material to be heated includes an aerosol generating material and a tobacco material, such as bold tobacco. In some embodiments, one or more particles of aerosol generating material may be included in a cigarette. For example, one or more particles of aerosol generating material may be dispersed within a tobacco material, such as bold or reconstituted tobacco, to contribute to the active substances and flavor provided by the tobacco. In other embodiments, the aerosol generating material of the hybrid system consists of particles of the aerosol generating material.

4 shows a cross-sectional view of an example of a hybrid article for heating a liquid and an aerosol generating material. The device 21 has a housing 22 comprising a chamber 24 containing an aerosol generating material that will be heated and volatilized in use. In this embodiment, the aerosol generating material is in the form of a monolithic aerosol generating material 23 . However, the aerosol generating material may be a plurality of particles of aerosol generating material provided in a cartridge such as illustrated in FIG. 5 or held in a chamber. Housing 22 also includes a liquid reservoir 25 containing liquid 26 to be heated to form vapor.

Device 21 further has an electronics/power chamber 27 which may include, for example, electrical control circuitry and/or a power source (not shown). The electrical control circuitry may include a controller, such as a microprocessor arrangement, constructed and arranged to control heating of the aerosol generating material and liquid 26 via one or more heating elements (not shown). Electrical control circuitry may enable device 21 to be puff-actuated to heat the aerosol generating material “on demand”. Alternatively, device 22 may have a manually operable switch for the user to initiate a puff.

The housing 22 also includes an inlet 28 through which air is drawn into the device. Housing 22 also includes an outlet 29 for mouthpiece 30 of device 21 . Air is drawn into the device 21 through the inlet 28, the vapor produced by heating the liquid 26 in the liquid reservoir 25, and the active substance(s) released by the aerosol generating material 23 and The resulting aerosol produced by the device 21, which travels through the device picking up the volatile components, leaves the device 21 via the outlet 29 and is inhaled by the user.

The hybrid device 21 shown schematically in FIG. 4 represents just one possible configuration of such a device. The relative positions of the liquid reservoir 25 and the aerosol-generating material chamber 24 can be varied, just as the path of air flowing through the device can be altered.

In one embodiment, the liquid reservoir is positioned upstream of the aerosol generating material to be volatilized. Alternatively, the liquid reservoir may be positioned downstream of the aerosol generating material to be volatilized. In yet a further arrangement, the two aerosol sources in the device can be arranged side by side, and so on.

In some embodiments, the vapor produced by heating the liquid in the liquid reservoir flows over or through the aerosol generating material comprising or consisting of one or more aerosol generating materials. In some embodiments, the elevated temperature of the vapor causes the active material and volatile components to be released. Alternatively or additionally, the aerosol generating material may be individually heated by means of a heating means.

In some embodiments, a hybrid device is provided in which vapor generated by heating a liquid heats the aerosol generating material to volatilize at least one component of the aerosol generating material. In some embodiments, the liquid is a nicotine-free liquid. In other embodiments, the liquid contains nicotine. Where the aerosol-generating material is heated by the vapor to volatilize at least one component of the aerosol-generating material, in certain embodiments the device does not include separate means for heating the aerosol-generating material.

In other embodiments, the vapor produced by heating the liquid in the liquid reservoir does not flow over or through the aerosol generating material. Rather, this vapor and the aerosol produced by heating the aerosol-generating material are mixed only after they are both formed.

In some embodiments, the tobacco heating products and hybrid products described herein may include an aerosol generating material in the form of containers or cartridges containing the aerosol generating material. These containers or cartridges may be removable. These may replace both the aerosol-generating material and the chamber for holding the aerosol-generating material in the device described above with reference to FIGS. 3 and 4 and in the alternative embodiments discussed.

Referring to FIG. 5 , a tobacco segment cartridge 31 is shown comprising a housing 32 defining a cavity (not shown) within which one or more particles of an aerosol generating material are held. The housing 32 may be made of, for example, molded plastic or the like. Vent holes 33 are provided in the housing of the cartridge 31 to allow air drawn through the device to pass into the cartridge 31 and over or through one or more particles of aerosol generating material and then out of the cartridge 31 . 32) is provided. In some embodiments, the cartridge 31 may further comprise heating means heatable by suitable means for heating the one or more particles of aerosol generating material held therein.

Example

In this experiment, menthol was used as a volatile component injected into tobacco granules to form a nicotine delivery composition. Individual menthol particles were used as a source of volatile components.

The injection step utilizes the low vapor pressure of menthol to move the menthol from the individual menthol particles into menthol pockets present within the porous surface of the tobacco granules that are later released when the nicotine delivery composition is heated to create an aerosol. The injection process involved adding menthol particles to a bag containing tobacco granules and leaving them for a specified period of time in a controlled environment.

The performance of the mentholized infused granules was tested to evaluate the impact of inclusion of menthol in the composition when the granules were incorporated into a hybrid device.

Extruded tobacco granules were formed from a feedstock comprising ground tobacco particles, sodium carbonate (Na ₂ CO ₃ ), carboxymethylcellulose (CMC) and water. The pH of the feedstock used was 8.5 for each of the samples produced.

In this study, various menthol loading levels were used as shown in the table below.

A nicotine delivery composition was included in the hybrid device with 430 mg of the nicotine delivery composition contained in a pod. For the purposes of this experiment, the liquid contained in the device to form the aerosol was a proxy, unscented liquid. Figures show average menthol delivery per puff over a course of 60 puffs.

The data show that the nicotine delivery composition provides a steady release of menthol, a volatile component.

The various implementations described herein are presented only as an aid in teaching and understanding the claimed features. These implementations are provided only as a representative sample of implementations, and are not exhaustive and/or exclusive. The advantages, implementations, examples, functions, features, structures and/or other aspects described herein are not limitations on the scope of the invention as defined by the claims or limitations on equivalents of the claims. It should be understood that other implementations may be utilized and modifications may be made without departing from the scope of the claimed invention. Various embodiments of the present invention suitably include, consist of, or consist of appropriate combinations of the disclosed elements, elements, features, parts, steps, means, etc. other than those specifically described herein. , or may be configured with these as essential elements. In addition, the disclosure may cover other inventions not currently claimed that may be claimed in the future.

The delivery system described herein may be implemented as a combustible aerosol delivery system, a non-combustible aerosol delivery system, or a non-aerosol delivery system.

Claims (34)

an aerosol-generating material comprising at least one particle comprising an active substance, and a volatile component, wherein the volatile component has a vapor pressure at 20° C. that is equal to or greater than the vapor pressure at 20° C. of the active substance; An aerosol-generating material is incorporated into the aerosol-generating material by injection, wherein the release of the active substance from the aerosol-generating material is controlled by competition with the release of the volatile component. The aerosol generating material according to claim 1 , for inclusion in an aerosol delivery system. An aerosol-generating material according to claim 1 or 2, wherein the active substance is nicotine. 4. Aerosol generating material according to any one of claims 1 to 3, wherein the particles comprising the active substance are tobacco particles. 5. An aerosol-generating material according to any one of claims 1 to 4, wherein the vapor pressure of the volatile component is at least 6 Pa at 20°C. 6. An aerosol-generating material according to any one of claims 1 to 5, wherein the volatile component is a volatile flavor. 7. An aerosol-generating material according to claim 6, wherein the volatile component is selected from the group consisting of menthol, limonene, linalool, camphene and eucalyptol. 6. An aerosol-generating material according to any one of claims 1 to 5, wherein the volatile component has no characteristic or characteristic flavor. 9. The aerosol generating material according to any one of claims 1 to 8, wherein the pH of the aerosol generating material is from about 4 to about 9.5. 10. The aerosol-generating material according to claim 9, wherein the pH of the aerosol-generating material is increased by the addition of one or more bases or a basic buffering system. 11. The method of claim 10, wherein the one or more bases are selected from the group consisting of hydroxides, carbonates and hydrogen carbonates, and optionally, the one or more bases are selected from the group consisting of potassium hydroxide, sodium hydroxide, sodium carbonate, and sodium bicarbonate. Optional, aerosol generating material. 12. The aerosol-generating material according to any preceding claim, wherein the particles comprising the active substance have an average diameter of less than 3 mm, less than 1 mm, less than 0.5 mm or less than 0.3 mm. 13 . The aerosol generating material according to claim 1 , further comprising one or more aerosol formers. 14. The aerosol generating material of claim 13, wherein the aerosol former is selected from the group consisting of glycerol, propylene glycol and glyceryl triacetate. 15. The aerosol generating material according to any one of claims 1 to 14, further comprising one or more binders. 16. The method of claim 15, wherein the one or more binders are thermoreversible gelling agents, such as gelatin; starches; polysaccharides; pectins; celluloses; cellulose derivatives such as carboxymethylcellulose; and alginates. 17. Aerosol generating material according to any one of claims 1 to 16, wherein the precursor composition comprising particles comprising the active substance is granulated or spheronized to form an agglomerated structure. 18. An aerosol-generating material according to any one of claims 1 to 17, wherein a precursor composition comprising particles comprising the active material is extruded to form an agglomerated structure. 19. Aerosol generating material according to any one of claims 1 to 18, in the form of granules. An aerosol dispensing system comprising an aerosol generating material according to claim 1 . 21. The system of claim 20, wherein the system is an aerosol generating material heating system comprising an aerosol generating material to be heated to volatilize the constituents, optionally comprising a filter or filter element. 21. The system of claim 20, wherein the system is a hybrid system comprising an aerosol generating material to be heated to volatilize the constituents, and a liquid to be heated to form vapor, and optionally comprising a filter or filter element. 23. The system of claim 22, wherein the aerosol generating material is comprised of one or more particles of the aerosol generating material. 23. The system of claim 22, wherein the aerosol generating material is heated by the vapor. 25. The system of claim 24, wherein the liquid is a nicotine-free liquid. 26. The system according to claim 24 or 25, wherein the device includes means for heating the liquid to form vapor, but does not include separate means for heating the aerosol generating material. A method for preparing an aerosol generating material comprising particles comprising an active agent and a volatile component for use in an aerosol delivery system, the method forming an agglomerated structure comprising particles comprising the active agent and incorporating the volatile component into the agglomerated structure by injection, wherein the volatile component has a vapor pressure at 20°C that is equal to or greater than the vapor pressure at 20°C of the active material. . 28. The method of claim 27, wherein the aerosol-generating material is formed from a precursor composition comprising particles comprising an active substance, and wherein the resulting composition is infused with the volatile component. 29. The method of claim 28, wherein the precursor composition is granulated or spheronized to form an agglomerated structure. 29. The method of claim 28, wherein the precursor composition is extruded to form an agglomerated structure. An apparatus for heating an aerosol-generating material to volatilize at least one component of the aerosol-generating material, and for heating a nicotine-free liquid to be heated to form a vapor, wherein the aerosol-generating material comprises: An apparatus comprising an aerosol generating material according to claim 1 , wherein the aerosol generating material is heated by the vapor. 32. The device of claim 31 comprising means for heating the liquid to form vapor, but not comprising separate means for heating the aerosol generating material. 33. The device of claim 31 or 32, wherein the addition of the one or more bases or basic buffer system increases the pH. Particles comprising a volatile component by injection, wherein the volatile component has a vapor pressure at 20°C that is equal to or greater than the vapor pressure at 20°C of the active substance for use in controlling the release of nicotine in an aerosol generating material. , particle.

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