KR20230002788A - 신피질 레이어 5 글루타메이트성 뉴런에서 유전자 발현을 선택적으로 조절하기 위한 인공 발현 작제물 - Google Patents

신피질 레이어 5 글루타메이트성 뉴런에서 유전자 발현을 선택적으로 조절하기 위한 인공 발현 작제물 Download PDF

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KR20230002788A
KR20230002788A KR1020227040046A KR20227040046A KR20230002788A KR 20230002788 A KR20230002788 A KR 20230002788A KR 1020227040046 A KR1020227040046 A KR 1020227040046A KR 20227040046 A KR20227040046 A KR 20227040046A KR 20230002788 A KR20230002788 A KR 20230002788A
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ehgt
wpre3
bghpa
coding sequence
heterologous coding
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타냐 다이겔
루카스 티. 그레이벅
브라이언 에드워드 캄바크
에드워드 세바스찬 레인
보아즈 피. 레비
존 케이. 미치
아드리아나 에스텔라 세데노 코르테스
보실즈카 타식
조나단 팅
홍쿠이 젱
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알렌 인스티튜트
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KR1020227040046A 2020-04-21 2021-04-21 신피질 레이어 5 글루타메이트성 뉴런에서 유전자 발현을 선택적으로 조절하기 위한 인공 발현 작제물 Pending KR20230002788A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063013342P 2020-04-21 2020-04-21
US63/013,342 2020-04-21
PCT/US2021/028489 WO2021216778A2 (en) 2020-04-21 2021-04-21 Artificial expression constructs for selectively modulating gene expression in neocortical layer 5 glutamatergic neurons

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KR20230002788A true KR20230002788A (ko) 2023-01-05

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US (1) US20230159952A1 (https=)
EP (1) EP4139462A4 (https=)
JP (2) JP7721568B2 (https=)
KR (1) KR20230002788A (https=)
AU (1) AU2021261359A1 (https=)
CA (1) CA3175993A1 (https=)
WO (1) WO2021216778A2 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4413142A4 (en) * 2021-10-05 2025-11-05 Allen Inst ARTIFICIAL EXPRESSION CONSTRUCTIONS TO MODULATE GENE EXPRESSION IN THE CEREBELLUM AND IN A SECONDARY CELL TYPE
JP2025520385A (ja) * 2022-06-13 2025-07-03 アレン インスティテュート 中枢神経系の非神経細胞において遺伝子発現を調節するための人工発現コンストラクト
WO2025059552A1 (en) * 2023-09-14 2025-03-20 Allen Institute Artificial expression constructs for modulating gene expression in the basal ganglia
WO2025179180A1 (en) * 2024-02-23 2025-08-28 Allen Institute Artificial expression constructs for modulating gene expression in motor neurons and cerebellar neurons

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9920317B2 (en) * 2010-11-12 2018-03-20 The General Hospital Corporation Polycomb-associated non-coding RNAs
US10973930B2 (en) * 2016-02-18 2021-04-13 The Penn State Research Foundation Generating GABAergic neurons in brains
WO2020076614A1 (en) * 2018-10-08 2020-04-16 Allen Institute Artificial expression constructs for selectively modulating gene expression in interneurons
AU2019357039B2 (en) * 2018-10-12 2025-10-09 Genzyme Corporation Generation of improved human pah for treatment of severe PKU by liver-directed gene replacement therapy
US20220249703A1 (en) * 2019-02-15 2022-08-11 Allen Institute Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations

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US20230159952A1 (en) 2023-05-25
JP7721568B2 (ja) 2025-08-12
CA3175993A1 (en) 2021-10-28
WO2021216778A2 (en) 2021-10-28
EP4139462A2 (en) 2023-03-01
WO2021216778A3 (en) 2021-12-16
AU2021261359A1 (en) 2022-12-08
JP2025163106A (ja) 2025-10-28
EP4139462A4 (en) 2025-03-12
JP2023522708A (ja) 2023-05-31

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