KR20220167076A - Needleless microjet injection device - Google Patents

Abstract

The present invention provides a needle-free jet injection device comprising: a syringe in which a nozzle hole with a micro-sized diameter is formed, a receiving space communicating with the nozzle hole receives pressurized effective drug, and the nozzle hole is opened by the rise of an opening and closing needle provided in the nozzle hole, wherein the syringe releases the effective drug contained in the receiving space; an injection chamber provided on one side of the syringe, connected to a drug channel, and receiving an effective drug in an internal space; a pressurizing means provided in the injection chamber and pressurizing the effective drug by providing pressure to the internal space of the injection chamber; a spray speed control means that is physically connected to the opening and closing needles and controls the raising and lowering of the opening and closing needles selectively by an externally applied control signal to adjust the spraying speed of the microjet water stream in multiple stages; and a control unit electrically connected to the spray speed control means and electrically controlling the spray speed control means. By controlling the opening and closing needle that opens and closes the micro-sized diameter nozzle hole using an actuator using piezoelectric or Lorentz force that is dynamically controlled by an electrical signal, skin puncturing is performed by spraying a high-speed microjet water stream of over 100 m/s for a short period of time, and then immediately sprayed is a relatively low-speed microjet water stream for a longer period of time. Thus, a drug injected through punctured skin causes spherical dispersion.

Description

Needleless microjet injection device {Needleless microjet injection device}

The present invention relates to a needle-free microjet injection device, and more particularly, by controlling an opening/closing needle for opening and closing a nozzle hole having a micro-sized diameter using an actuator using a piezoelectric or Lorentz force dynamically controlled by an electrical signal, A needle-free jet injection device for injecting a drug through the skin by controlling the speed of a microjet sprayed through a nozzle hole in multiple steps for each corresponding time.

As a drug delivery system for injecting drugs into the body, a syringe with a needle has traditionally been used. However, these traditional syringes have been feared by patients due to pain during injection, and have unavoidable problems such as fear of infection due to wounds.

In order to solve these problems, drug delivery systems such as needle-free injectors are being developed, and as part of this research, drugs are sprayed at high speed in a microjet method to directly penetrate the body through the epidermis. A drug delivery system of the method is presented.

In order to generate such high-speed injection of the microjet method, it is necessary to accurately and powerfully inject the drug to the outside (ie, the skin). This spraying method has been developed in various ways since the 1930s. Recently, a spraying method using a piezoelectric ceramic element, a spraying method using a shock wave caused by applying a laser beam to an aluminum foil, and a spraying method using the Lorentz force Various spraying methods have been developed.

For example, Patent Publication No. 10-2009-0051246 discloses a needle-free transdermal delivery device comprising a chamber for holding a substance to be injected, a nozzle in fluid communication with the chamber, and a drug reservoir for storing the substance to be delivered to the chamber. is disclosed.

The needle-free transdermal delivery device also includes a controllable magnet and coil electromagnet actuator in communication with the chamber.

The actuator accepts electrical input and generates force in response. The force causes needle-free transfer of the material from the chamber to the living body.

In addition, recently, unlike the conventional microjet injection, the amount of drug injected and the injection speed of the drug can be finely controlled, continuous injection is possible, and the laser-bubble method is reusable. of microjet injection method was developed.

For example, in Registered Patent No. 10-1500568 and Registered Patent No. 10-1834773, the liquid for pressure generation is rapidly vaporized using a laser to increase the pressure so that the elastic membrane disposed between the drug and the liquid for pressure generation is directed toward the drug. A deformable laser bubble-type microjet drug delivery device is disclosed. However, there are limitations in miniaturization and popularization due to the size and cost of laser equipment.

A conventional needle-free injection device used a mechanical operation method by compressed air or a spring. In these systems, once injection is started, the injection characteristics cannot be changed midway through. Therefore, an electric operating device using a piezo element is an alternative, but there is a problem in that the water stream generating the piezo element lacks sufficient force to penetrate the piston due to the small movement of the piston.

The present invention adjusts the opening and closing needles that open and close nozzle holes having micro-sized diameters using actuators using piezoelectricity or Lorentz force dynamically controlled by electrical signals, thereby controlling the speed of the microjet jetted through the nozzle holes at each corresponding time. Its object is to provide a needle-free jet injection device for injecting drugs through the skin by multi-stage control.

In the needle-free microjet injection device according to the present invention, a nozzle hole having a micro-sized diameter is formed, a pressurized effective drug is accommodated in an accommodation space communicating with the nozzle hole, and an opening/closing needle provided in the nozzle hole rises to a syringe having a nozzle hole opened to release an effective drug contained in the accommodation space; an injection chamber provided on one side of the syringe, connected to a drug channel, and accommodating an effective drug in an internal space; a pressurizing means provided in the injection chamber and providing pressure to an inner space of the injection chamber to pressurize an effective drug; an ejection speed adjusting means physically connected to the opening/closing needle and selectively controlling the elevation of the opening/closing needle according to a control signal applied to the outside to continuously adjust the ejection speed of the microjet stream in multiple stages; and a control unit that is electrically connected to the jet speed control unit and electrically controls the jet speed control unit.

At this time, the injection speed adjusting means according to the present invention is physically connected to the opening and closing needles, and a spring that provides elasticity to the opening and closing needles in a descending direction, and a spring physically connected to the opening and closing needles and electrical power applied by the control unit. and an actuator for displacing the opening/closing needle in response to a signal.

And it is provided as an actuator of any one of a piezoelectric actuator or a Lorentz force actuator that displaces the opening/closing needle with an electrical signal applied from the outside according to the present invention.

In addition, it is preferable that the controller according to the present invention multistagely controls the spraying speed adjusting means so that a micjet water stream with a speed of 100 m/s or more and a micjet water stream with a relatively low speed are jetted during a corresponding time period.

In addition, the syringe according to the present invention forms a plurality of nozzle holes spaced apart from each other at regular intervals, and each of the plurality of nozzle holes has an opening and closing needle for opening and closing the nozzle holes, so that the plurality of nozzle holes are identical to each other, It can fire a stream of micjets at different jetting speeds.

The effects of the needle-free microjet injection device according to the present invention are as follows.

Using an actuator using piezoelectricity or Lorentz force dynamically controlled by an electrical signal, by adjusting the opening and closing needles that open and close the micro-sized nozzle ball, the microjet water stream at a high speed of 100 m/s or more is sprayed for a short time to treat the skin. After the puncture, a relatively low-velocity microjet stream is immediately jetted for a longer period of time to cause a spherical dispersion of the drug injected through the punctured skin.

1 is an exemplary view showing a needle-free microjet injection device according to an embodiment of the present invention.
2 is a graph showing the speed of a microjet water stream injected during a corresponding time of a needle-free microjet injection device according to an embodiment of the present invention.
3 is an exemplary view showing a state in which a plurality of nozzle holes of a needle-free microjet injection device according to an embodiment of the present invention are formed.
Figure 4 is a graph showing the displacement of the opening and closing needle and the speed of the microjet water stream sprayed during the corresponding time by the spraying speed adjusting means according to an embodiment of the present invention.
5 is a graph showing a change in speed of a water stream of a microjet according to a degree of displacement of an opening/closing needle for a corresponding time by means of an injection speed adjusting unit according to an embodiment of the present invention.
6 is a graph showing a state in which a water jet of a microjet is jetted in a pulse form to an jetting speed adjusting means according to an embodiment of the present invention.

Hereinafter, preferred embodiments according to the present invention will be described in detail with reference to the accompanying drawings. Prior to this, the terms or words used in this specification and claims should not be construed as being limited to the usual or dictionary meaning, and the inventor appropriately uses the concept of the term in order to explain his/her invention in the best way. Based on the principle that it can be defined, it should be interpreted as meaning and concept consistent with the technical spirit of the present invention.

Therefore, the embodiments described in this specification and the configurations shown in the drawings are only the most preferred embodiments of the present invention, and do not represent all the technical ideas of the present invention, so at the time of this application, they are equivalent alternatives that can be replaced. It should be understood that variations may exist.

The present invention uses an actuator using piezoelectricity or Lorentz force dynamically controlled by an electrical signal to control the opening and closing needles that open and close the micro-sized nozzle ball, thereby spraying a microjet water stream at a high speed of 100 m/s or more for a short period of time. After perforating the skin, immediately spraying a relatively low-speed microjet water stream for a longer period of time so that the drug injected through the perforated skin causes a spherical dispersion. Referring to the drawings, Looking at it:

Referring to FIG. 1, the needle-free jet injection device according to an embodiment of the present invention includes a syringe 100, an injection chamber 200, a pressurizing means 300, an injection speed adjusting means 400, and a controller 500. First, the syringe 100 has a cylindrical body 110, and inside the body 110 of the syringe 100, an accommodation space 111 accommodating a pressurized effective drug in a corresponding amount is provided. form

At this time, a nozzle hole 112 having a micro-sized diameter is formed on the lower side of the accommodation space 111 of the body 110, and the nozzle hole 112 has a conical shape that becomes narrower from the upper side to the lower side.

The nozzle hole 112 is provided with an opening/closing needle 120 that selectively moves up and down to open and close the nozzle hole 112 .

Here, it is preferable that the lower end of the opening/closing needle 120 also forms a conical shape that becomes narrower from the upper side to the lower side to correspond to the nozzle hole 112 .

Therefore, when the opening/closing needle 120 descends, the lower end of the opening/closing needle 120 comes into contact with the upper side of the nozzle hole 112 to form the closed state of the nozzle hole 112. As the opening and closing needle 120 is separated from the nozzle hole 112 by the rising of the opening and closing needle 120, the effective drug contained in the accommodation space 111 of the body 110 is released through the nozzle hole 112. to form the open state of the nozzle hole 112.

In addition, one side of the syringe 100 is provided with an injection chamber 200, and the injection chamber 200 is connected to a drug channel 201 through which the drug pressurized on one side of the syringe 100 flows, The effective drug is accommodated in the inner space.

Here, the injection chamber 200 is provided with a pressurizing means 300, and the pressurizing means 300 selectively pressurizes the effective drug accommodated in the inner space of the injection chamber 200.

At this time, the pressurizing means 300 may be used as compressed air or a spring-driven actuator.

The needle-free jet injection device according to an embodiment of the present invention includes a jetting speed adjusting means 400 for selectively adjusting the speed of the microjet water stream ejected from the nozzle hole 112 in multiple stages, the jetting speed adjusting means ( 400) is physically connected to the opening/closing needle 120 and selectively controls the elevation of the opening/closing needle 120 by an electrical signal (control signal) applied to the control unit 500 to adjust the spraying speed of the microjet stream. do.

Here, looking at the injection speed adjusting means 400 in more detail, it includes a horizontal bar 121 to which the upper end and one side of the opening and closing nozzle 120 are connected, and an actuator 410 at the bottom of the other side of the horizontal bar 121 ), and a spring 420 is provided on the upper part of the other side of the horizontal bar 121 facing the actuator 410.

At this time, a support part 113 is extended on the other side of the body 110 of the syringe 100, and the support part 113 is extended in a '[' shape, and the lower side is integrally formed with the other side of the body 110. connected, and the spring 420 is supported on the upper side.

Accordingly, the spring 420 provides elasticity to the opening/closing nozzle 120 connected to the horizontal bar 121 in a descending direction.

The actuator 410 is preferably provided with either a piezoelectric actuator or a Lorentz force actuator, and the actuator 410 is electrically connected to the controller 500, and an electrical signal applied by the controller 500 (control signal) to control the displacement (elevation) of the opening/closing needle 120 by being driven dynamically (length extension).

In addition, the control unit 500 electrically connected to the spraying speed adjusting unit 400 selectively sends a voltage as an electrical signal to the spraying speed adjusting unit 400 so that the microjet water stream at the corresponding speed is sprayed from the nozzle hole 112. Alternatively, by generating a frequency, the generated voltage and frequency are applied to the injection speed control means 400 to control the injection speed control means 400.

At this time, it is preferable that the control unit 500 generates an electrical signal so that the ejection speed of the microjet stream is multi-stage.

Therefore, the micro water stream of the needle-free microjet injection device according to an embodiment of the present invention with reference to FIG. 2 is micro-water by the energy movement of the effective drug pressurized by the pressurizing means 300 in the inner space of the injection chamber 200. The nozzle hole 112 of the syringe 100 generates a microjet water stream at a high speed of 100 m/s or more.

The microjet water stream penetrates the skin when the stagnant pressure (about 15 MPa in the case of human skin) is exceeded. (This phenomenon appears at the beginning of the injection and appears according to the peak of the stagnation pressure value.)

Subsequently, a relatively low-velocity microjet stream is continuously jetted to cause a spherical dispersion of the injected liquid within the skin layer.

Combining the energy efficiency of mechanical systems with the dynamic control of electrical systems is an unprecedented approach. The electrical control can control the degree of opening of the nozzle hole 112 and thereby control the speed of injection.

Therefore, it can be used for pulse injection or two-velocity injection.

In addition, in the needle-free microjet injection device according to an embodiment of the present invention with reference to FIG. 3, the syringe 100 forms a plurality of nozzle holes 112 spaced apart from each other at regular intervals, and the plurality of nozzle holes 112 ) Each nozzle hole 112 may be provided with an opening/closing needle 120 that opens and closes the nozzle holes 112, so that the plurality of nozzle holes 112 may spray the mic jet stream at the same spraying speed.

The nozzle hole 112 of the needle-free microjet injection device according to an embodiment of the present invention described above adjusts the displacement of the opening/closing needle 120 operated by a piezoelectric or Lorentz force actuator, which is the jetting speed adjusting means 400, to obtain the necessary Dynamic control can be obtained.

), 수직선상을 기준으로 상기 개폐니들(120)의 하단 외주변 각도(

), 상기 개폐니들(120) 끝단의 변위(s), 및 상기 노즐공의 길이(h)를 갖고, 상기 노즐공(112)의 외주변 기울기 각도(

), 수직선상을 기준으로 상기 개폐니들(120)의 하단 외주변 각도(

) 및 상기 노즐공의 길이(h)는 고정된 값으로 상기 개폐니들(120) 끝단의 변위(s)로 상기 노즐공을 통해 분사되는 마이크로젯 물줄기의 속도를 조절할 수 있다.4 to 6 show the change in speed of the microjet water stream according to the displacement of the opening and closing needle 120, and the effective nozzle change parameter is the inclination angle of the outer periphery of the nozzle hole 112 with respect to the horizontal line (

), the outer peripheral angle of the lower end of the opening and closing needle 120 based on the vertical line (

), the displacement (s) of the end of the opening and closing needle 120, and the length (h) of the nozzle hole, and the outer peripheral inclination angle of the nozzle hole 112 (

), the outer peripheral angle of the lower end of the opening and closing needle 120 based on the vertical line (

) and the length (h) of the nozzle hole is a fixed value, and the speed of the microjet stream sprayed through the nozzle hole can be controlled by the displacement (s) of the tip of the opening/closing needle 120.

Here, the displacement (s) of the end of the opening/closing needle 120 varies depending on the voltage applied to the actuator 410 (piezoelectric/Lorentz force actuator) of the jetting speed adjusting means 400.

When the control unit 500 applies an electric signal having a changed voltage or frequency to the actuator (410: piezoelectric / Lorentz force actuator) of the injection speed adjusting means 400, the displacement (s) of the tip of the opening and closing needle 120 is changed to a corresponding displacement, so that the microjet water stream can perform multi-stage injection and pulse injection.

Therefore, the needle-free jet injection device according to an embodiment of the present invention uses an actuator using piezoelectricity or Lorentz force dynamically controlled by an electrical signal to adjust the opening and closing needles that open and close the micro-sized nozzle hole, In the penetration step, the maximum speed of the microjet stream is controlled, and then the injection characteristics can be controlled by controlling the speed of the microjet stream as the average speed.

Although the present invention has been described with reference to the embodiments shown in the drawings, this is merely exemplary, and those skilled in the art will understand that various modifications and equivalent other embodiments are possible therefrom. Therefore, the true technical protection scope of the present invention should be determined by the technical spirit of the appended claims.

100: syringe
110: body
111: accommodation space
112: nozzle ball
113: support
120: opening and closing needle
121: horizontal bar
200: injection chamber
201: drug channel
300: pressurization means
400: injection speed control means
410: actuator
420: spring
500: control unit

Claims (5)

A nozzle hole having a micro-sized diameter is formed, and a pressurized effective drug is accommodated in an accommodation space communicating with the nozzle hole, and the nozzle hole is opened by lifting of an opening/closing needle provided in the nozzle hole, so that the accommodation space accommodated in the accommodation space a syringe that releases an effective drug;
an injection chamber provided on one side of the syringe, connected to a drug channel, and accommodating an effective drug in an internal space;
a pressurizing means provided in the injection chamber and providing pressure to an inner space of the injection chamber to pressurize an effective drug;
an ejection speed adjusting means physically connected to the opening/closing needle and selectively controlling the elevation of the opening/closing needle according to a control signal applied to the outside to continuously adjust the ejection speed of the microjet stream in multiple stages; and
A needle-free microjet injection device comprising: a control unit electrically connected to the jet speed control unit and electrically controlling the jet speed control unit.
The method of claim 1,
The spray speed control means
a spring physically connected to the opening and closing needles to provide elasticity to the opening and closing needles in a descending direction;
and an actuator physically connected to the opening/closing needle to displace the opening/closing needle in response to an electrical signal applied by the control unit.
The method of claim 2,
the actuator
A needle-free microjet injection device provided with either a piezoelectric actuator or a Lorentz force actuator for displacing the opening/closing needle with an electrical signal applied from the outside.
The method of claim 2,
The control unit
A needle-free microjet injector that controls the ejection speed adjusting means in multiple stages so that a micjet stream of 100 m/s or more and a micjet stream of relatively low speed are jetted during a corresponding time.
The method of claim 1,
The syringe is
Forming a plurality of nozzle holes spaced apart from each other at regular intervals,
Each of the plurality of nozzle holes has an opening/closing needle for opening and closing the nozzle holes, so that the plurality of nozzle holes spray the micjet water stream at the same or different spraying speeds.

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