KR20220151135A - Medical implant for improvement in wrinkle - Google Patents

Abstract

According to the present invention, a prosthesis includes a frame portion formed along an imaginary closed curved surface to form an inner space and having a plurality of through-holes formed so that the inside and outside communicate with each other. The frame portion is made of any one of cross-linked hyaluronic acid (HA), cat gut, polydioxanone (PDS), polyglactin (Vicryl), polyglutamic acid (PGA), polylactic acid (PLA), poly(lactic-co-glycolic) acid (PLGA), polyamide (nylon), polypropylene (Prolene), polypehyl ether (PPE), polyester, polyethylene, polycaprolactone (PCL), polylactic acid (PLLA), seaweed calcium, and bone cement. According to the prosthesis of present invention, by injecting a granular prosthesis into wrinkles, etc., an effect of maintaining a position in an inserted region is increased compared to a wire-type prosthesis, etc. In addition, compared to a liquid-type prosthesis or a gel-type prosthesis, problems such as dripping is reduced, and the prosthesis can be maintained naturally according to muscle movement.

Description

Medical implant for improvement in wrinkle}

The present invention relates to a medical implant for improving wrinkles, and relates to an implant for improving wrinkles and the like due to aging.

Various methods are used for the purpose of restoring a damaged human body such as a depression due to an unexpected accident or disease or improving the appearance of a woman's breast. For example, implants, fillers, etc. may be used to aesthetically improve the shape of the breast, which may be necessary after tumor removal, and implants, fillers, or botox may be used to improve wrinkles.

In particular, facial wrinkles can be caused by frowning or frequent laughter, and botox or fillers are used depending on the condition, shape, and depth of these wrinkles. For example, in the case of shallow wrinkles, symptoms can be alleviated by using muscle-reducing botox, etc., and in the case of deep wrinkles that have already occurred, wrinkles are improved by lifting or inserting fillers in addition to Botox treatment.

However, in the case of a procedure using botox or filler, there is a problem in that the effect rapidly decreases due to the decomposition and absorption of the contents in the human body as a certain period of time elapses.

(Patent Document 1) KR 10-2011-0075618 A1

The present invention not only increases the effect of maintaining the position in the inserted position compared to wire-type implants, etc., but also reduces problems such as dripping compared to liquid-type or gel-type implants, and provides an implant that can be naturally maintained according to muscle movement. to provide.

The implant according to the present invention includes a frame portion formed along an imaginary closed curved surface to form an inner space portion and formed with a plurality of through-holes through which the inside and the outside communicate, wherein the frame portion includes cross-linked hyaluronic acid (HA) and catgut. (Cat gut), Polydioxanone (PDS), Polyglactin (Vicryl), Polyglutamic Acid (PGA), Polylactic acid (PLA), Poly(Lactic- co-Glycolic)Acid (PLGA), Polyamide, Nylon, Polypropylene, Prolene, Polyphenylether, PPE, Polyester, Polyethylene, PCL (Polycaprolactone) , PLLA (Polylactic acid), seaweed calcium, and bone cement.

In addition, the diameter of the frame portion may be formed to a size of 0.3 mm to 1 mm.

In addition, at least one of an antibiotic and a bleaching agent for treating skin pigmentation may be infiltrated into the frame part.

In addition, a capsule containing at least one of an antibiotic and a bleaching agent for treatment of skin discoloration may be provided in the inner space of the frame unit.

On the other hand, as a method for manufacturing the above implant, the first step of forming an inner core; a second step of forming an intermediate body by assembling a mixed powder in which particles of a first material and particles of a water-soluble second material are mixed outside the inner core; a third step of removing the particles of the water-soluble second material from the intermediate by putting the intermediate in water; and a fourth step of preparing an implant by drying the intermediate from which the particles of the water-soluble second material are removed, wherein the particles of the first material include cross-linked hyaluronic acid (HA), cat gut, polydioxa Polydioxanone (PDS), Polyglactin (Vicryl), Polyglutamic Acid (PGA), Polylactic acid (PLA), Poly(Lactic-co-Glycolic)Acid (PLGA) , Polyamide, Nylon, Polypropylene, Prolene, Polyphenylether, PPE, Polyester, Polyethylene, PCL(Polycaprolactone), PLLA(Polylactic acid), seaweed It may be formed of any one of calcium and bone cement.

Also, the inner core may be formed of the same material as the water-soluble second material.

In addition, the inner core may be formed of a single crystal of any one of sugar and salt.

In addition, the inner core may be a capsule containing at least one of an antibiotic and a bleaching agent for treatment of skin discoloration.

In addition, a fifth step of infiltrating the dried implant with any one of an antibiotic and a bleaching agent for treating skin discoloration may be further included.

In addition, the second step may include a 2-1 step of assembling the mixed powder outside the inner core by rolling the inner core on the mixed powder; and a 2-2 step of removing the remaining mixed powder by filtering the mixed powder and the inner core through a sieve having a predetermined size.

In addition, the second step may include a second-third step of heat-treating the assembled inner core and the mixed powder.

On the other hand, the method for manufacturing an implant according to the present invention is cross-linked hyaluronic acid (HA), cat gut, polydioxanone (PDS), polyglactin (Vicryl), polyglutamic acid (Polyglutamic acid) Acid (PGA), Polylactic acid (PLA), Poly(Lactic-co-Glycolic)Acid (PLGA), Polyamide (Nylon), Polypropylene (Prolene), Polyphenyl ether (Polypehyl ether) , PPE), polyester (Polyester), polyethylene (Polyetylene), PCL (Polycaprolactone), PLLA (Polylactic acid), seaweed calcium, the first step of forming particles of a first material that is any one of bone cement ; a second step of infiltrating the particles of the first material into water; and a third step of freeze-drying the particles of the first material impregnated with water.

The implant according to the present invention not only increases the effect of maintaining the position at the inserted position compared to wire-type implants by injecting granular implants into wrinkles, etc., but also avoids problems such as dripping compared to liquid-type or gel-type implants. It can be reduced and naturally maintained according to muscle movement.

1 is a schematic view showing an implant according to an embodiment of the present invention.
2 is a cross-sectional view showing an implant according to another embodiment of the present invention.
3 is a flowchart illustrating a method of manufacturing an implant according to an embodiment.
Figure 4 is a photograph showing crystals of salt available as an inner core according to one embodiment.
5 is a schematic diagram showing a process of forming a mixed powder according to an embodiment.
6 is a schematic diagram showing a method for forming an intermediate according to one embodiment.
7 is a schematic diagram showing an intermediate according to an embodiment.
8 is a schematic diagram showing a process of removing water-soluble substances from an intermediate according to an embodiment.
9 is a schematic diagram showing a general state (A) and a state in which moisture is absorbed in the body (B) of an implant according to an embodiment.

Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings. Unless there is a specific definition or reference, the terms indicating directions used in this description are based on the state shown in the drawings. In addition, the same reference numerals refer to the same members throughout each embodiment. On the other hand, the thickness or dimensions of each component shown in the drawings may be exaggerated for convenience of description, and it does not mean that the dimensions or proportions between the components should actually be configured.

A prosthesis according to an embodiment will be described with reference to FIGS. 1 and 2 . 1 is a schematic view showing an implant according to an embodiment of the present invention, and FIG. 2 is a cross-sectional view showing an implant according to another embodiment of the present invention.

As shown in FIG. 1 , the prosthesis according to the present embodiment includes a frame portion 110 . The frame part 110 is formed along an imaginary closed surface to form an inner space, and a plurality of through-holes 115 are formed so that the inside and outside communicate. The frame unit 110 is formed in a spherical shape for convenience of description, but may be formed in a spherical shape or various three-dimensional shapes according to the shape of an inner core in a manufacturing method to be described later.

The frame part 110 is made of cross-linked hyaluronic acid (HA), cat gut, polydioxanone (PDS), polyglactin (Vicryl), polyglutamic acid (PGA), Polylactic acid (PLA), Poly(Lactic-co-Glycolic)Acid (PLGA), Polyamide (Nylon), Polypropylene (Prolene), Polyphenyl ether (PPE), Poly It is made of any one of polyester, polyethylene, polycaprolactone (PCL), polylactic acid (PLLA), seaweed calcium, and bone cement.

As the material of the frame part 110, in addition to the materials mentioned above, various materials can be implemented with a lower dissolution rate than water-soluble materials (salt, sugar, etc.) to be described later within the limit of biocompatibility.

The diameter of the frame unit 110, that is, the outer diameter may be formed in a size of 0.3 mm to 1 mm, and the inner diameter may be formed in a size of 0.2 mm to 0.8 mm. However, the inner and outer diameters of the frame portion 110 may be variously applied to the extent of maintaining structural stability or insertion site of the human body.

In addition, the frame portion 110 may be provided in a state in which at least one of antibiotics, bleaching agents for skin pigmentation treatment, cytokines, lecithin, glucose preparations, and other cell differentiation inducers is infiltrated. When the frame part 110 is infiltrated with drugs such as antibiotics, when an implant including a plurality of frame parts 110 is injected into the human body, the effect of applying the drug can be obtained gradually, which causes the inconvenience of having to inject a separate drug. You can lessen your worries.

In this way, when the mesh-type frame part 110 having a certain inner space formed therein and having through-holes 115 penetrating the inside and outside is injected into the human body, biological tissue outside the frame part 110 penetrates the frame part 110. It can grow into the inner space.

Meanwhile, as another embodiment, as shown in FIG. 2 , a capsule C1 may be provided in the inner space of the frame unit 110 . Drugs such as osteomyelitis treatment, antibiotics, bleaching agent for skin discoloration treatment, cytokine, lecithin, glucose preparation, and other cell differentiation inducers may be contained inside the capsule C1. The capsule C1 is gradually decomposed in the human body and absorbed into the human body. In this way, the supply timing of the drug contained in the capsule (C1) can be controlled by using the time required for the capsule (C1) to be decomposed in the body. That is, the drug supply timing can be controlled by adjusting the thickness of the capsule C1.

After infiltrating the frame part 110 using cytokine, lecithin, glucose preparations, etc., it is applied to the human body so that it can be applied within the first week to promote cell migration and differentiation, and the time after 2 weeks In order to prevent inflammatory symptoms from occurring, the application timing of the drug may be adjusted in such a way that antibiotics are provided in the capsule C1.

A method for manufacturing an implant according to an embodiment will be described with reference to FIGS. 3 to 8 . 3 is a flow chart showing a method for manufacturing an implant according to an embodiment, FIG. 4 is a photograph showing crystals of salt usable as an inner core according to an embodiment, and FIG. 5 is a method for forming a mixed powder according to an embodiment. It is a schematic diagram showing the process. 6 is a schematic diagram showing a method for forming an intermediate according to an embodiment, FIG. 7 is a schematic diagram showing an intermediate according to an embodiment, and FIG. 8 is a method for removing water-soluble substances from an intermediate according to an embodiment. It is a schematic diagram showing the process.

A method of manufacturing an implant according to an embodiment includes the following steps as shown in FIG. 3 .

In the first step, an inner core is formed (S100), and in the second step, an intermediate body is formed by assembling a mixed powder in which particles of a first material and particles of a water-soluble second material are mixed outside the inner core (S200), In step 3, the intermediate is put into water to remove particles of the second material from the intermediate (S300), and in step 4, the intermediate from which the particles of the second material are removed is dried to manufacture an implant (S400). However, the first step can be omitted if the inner space is not separately formed, and in this case, the second step can assemble only the particles of the first material and the particles of the water-soluble second material into a spherical or three-dimensional shape.

Specifically, in the first step, the inner core is prepared. As the inner core, single crystals of sugar and salt or the like previously described capsules may be used.

Salt crystals are prepared as shown in FIG. 4 by preparing a supersaturated salt solution and then evaporating it. The salt crystals prepared in this way are grown to a certain size and used as they are, or vibration is generated after accommodating the salt crystals in a container of a certain size, or pressurization between particles is performed using the pressure rolling device 210 and 220 of FIG. Rubbing can reduce surface roughness. At this time, the average diameter of the salt crystals is formed to a size corresponding to the inner diameter of the frame portion described above.

In the second step, an intermediate body is formed by assembling a mixed powder in which particles of the first material and particles of the water-soluble second material are mixed on the outside of the aforementioned inner core. At this time, the particles of the first material (P2) include crosslinked hyaluronic acid (HA), cat gut, polydioxanone (PDS), polyglactin (Vicryl), polyglutamic acid Acid (PGA), Polylactic acid (PLA), Poly(Lactic-co-Glycolic)Acid (PLGA), Polyamide (Nylon), Polypropylene (Prolene), Polyphenyl ether (Polypehyl ether) , PPE), polyester, polyethylene, seaweed calcium, or bone cement.

As an example, hyaluronic acid is a natural polymer having a disaccharide repeating unit of D-glucuronic acid and D-N-acetylglucosamine bond, and is well known as an extracellular matrix that affects the growth and differentiation of cartilage, skin, nerves, and blood vessels in vivo. It is known and plays an important role as a wide range of biological reactions and structures in the human body. In terms of biological function, hyaluronic acid is reported to regulate tissue development and regeneration by affecting cell migration, differentiation, and signal transmission between cells. Hyaluronic acid, which has various biological functions, is degraded in vivo by hyaluronidase enzyme and hydrolysis in vivo. This biodegradable function has been recognized for its applicability as a biodegradable biomaterial in tissue regeneration engineering, and is being used in various ways as a biocompatible biomedical engineering material. Currently, hyaluronic acid is widely used as various biomaterials such as hydrogels, film-type anti-adhesion agents, tubular vascular scaffolds for tissue regeneration engineering, and hydrogels for plastic surgery, wound healing, and arthritis treatment.

In order to prepare particles of crosslinked hyaluronic acid, hyaluronic acid was dissolved in 1% NaOH aqueous solution to prepare a hyaluronic acid solution having a concentration of 7.5%, and 0.4 to 0.6% (v /v) Convert to mixed solution. After uniformly mixing the mixed solution, it was placed in a polyethylene mold (PE mold) and gelation was performed at room temperature for 24 hours. After mixing for 24 hours to induce a hyaluronic acid gel, a hyaluronic acid film having a diameter of 10 mm and a thickness of 2 mm is prepared. After washing the prepared film, it is pulverized with a homogenizer to form particulate hyaluronic acid.

As the particles of the second hydrophilic material, salt or sugar crystals may be pulverized and used as described above.

The prepared particles P1 of the first material and particles P2 of the second material are mixed as shown in FIG. 5, and the mixed powder is assembled on the outer surface of the inner core.

In the assembly process, the pressure rollers 210 and 200 may be used as shown in FIG. 6 . After the mixed powder (MP) is first laid on the base 200, the inner core (C1) is positioned on the mixed powder (MP), and the upper pressing part 210 is pressed with an appropriate force and moved.

Meanwhile, when the size of the inner core is not larger than that of the mixed powder, it is not necessary to separately form the inner core, and it is sufficient to simply assemble and form the mixed powder into a spherical shape.

Furthermore, it is also possible to form porous particles formed of the first material by freeze-drying the particles of the first material impregnated with water.

Through this device, the mixed powder (MP) can be evenly attached to the outside of the inner core.

It is also possible to replace this assembly process with a process of simply mixing and pressurizing the mixed powder MP and the inner core C1.

Thereafter, the mixed powder (MP) and the inner core (C1) are filtered through a sieve of a certain size to remove the remaining mixed powder. Particles of the first material and particles of the second material are preferably formed in a size of 10 to 30% compared to the inner core, and the remaining mixed powder (MP) and the assembled inner core (C1) use the difference in size +MP) isolate.

On the other hand, by heat-treating the assembled inner core and the mixed powder (C1+MP) so that the assembled mixed powder (MP) is fused, the fixing force can be improved, and it is also possible to add a binder such as resin instead of heat treatment. do. A binder may be added in the mixing step of FIG. 5 .

Hereinafter, the assembled inner core and the mixed powder (C1+MP) are referred to as an intermediate body 100P, and as shown in FIG. 7, the middle of the frame portion 110 formed of the first material and the frame portion 110 Particles P2 of the second material located in the middle can be observed.

In the third step, as shown in FIG. 8, the intermediate (100P) is put into distilled water to melt the inner core formed of a hydrophilic material and the particles (P2) of the second hydrophilic material so that they come out. At this time, the inner space where the inner core was located and the outer space where the particles of the first material were located become empty spaces to form the frame part 110 in the form of a porous shell.

Then, in the fourth step, the frame part 110 is dried. In the case of hyaluronic acid, when water is infiltrated, it becomes swollen, and on the contrary, when it dries and moisture escapes, it has the property of shrinking.

Next, as described above, the dried frame portion 110, that is, the implant, may be infiltrated with antibiotics or various therapeutic drugs and coated.

Referring to FIG. 9, a state in the case of application to the human body will be described. 9 is a schematic diagram showing a general state (A) and a state in which moisture is absorbed in the body (B) of an implant according to an embodiment.

As shown in FIG. 9 , the dried prosthesis 100a according to the present embodiment is mixed with physiological saline and injected into the human body. At this time, autologous blood (PRP) can be mixed.

When the frame part 110 of the mesh type, in which a certain inner space part is formed and the through hole 115 penetrating the inside and outside, is injected into the human body, biological tissue outside the frame part 110 enters the inner space of the frame part 110. can grow into

On the other hand, when a material such as hyaluronic acid is saturated with water, it is in a swelling state, and on the contrary, when it is dried and moisture escapes, it is obvious that it is dried and contracted. As described above, when the prosthesis 100A is injected into the human body, it expands in the living body, so that the size of the frame portion 110 is enlarged to increase the inner space, and at the same time, the size of the through hole 115 is also expanded.

In this state, biological tissue outside the prosthesis 100a may grow into the frame part 110 . At this time, when the frame part 110 is infiltrated with the drug and the capsule c1 contains antibiotics, the treatment action or cell differentiation action is promoted by the drug infiltrated at the beginning of the injection, and after a certain period of time, Inflammation and the like can be prevented as antibiotics inside the capsule c1 are gradually discharged.

Although the preferred embodiments of the present invention have been described above, the technical spirit of the present invention is not limited to the above-described preferred embodiments, and can be implemented in various ways within the scope of the technical spirit of the present invention embodied in the claims. have.

100, 100a: implant
110: frame part
115: through hole
C1: capsule
M1: Drugs

Claims (7)

A first step of preparing the inner core;
A second step of assembling a mixed powder in which particles of a first material and particles of a water-soluble second material are mixed to form an intermediate body;
a third step of removing the particles of the water-soluble second material from the intermediate by putting the intermediate in water; and
A fourth step of manufacturing an implant by drying the intermediate from which the particles of the water-soluble material 2 are removed;
The particles of the first material are cross-linked hyaluronic acid (HA), cat gut, polydioxanone (PDS), polyglactin (Vicryl), polyglutamic acid (PGA) , Polylactic acid (PLA), Poly(Lactic-co-Glycolic)Acid (PLGA), Polyamide (Nylon), Polypropylene (Prolene), Polyphenyl ether (PPE), It is formed of any one of polyester, polyethylene, PCL (Polycaprolactone), PLLA (Polylactic acid), seaweed calcium, and bone cement,
In the second step, a mixed powder in which particles of a first material and particles of a water-soluble second material are mixed is assembled outside the inner core. According to claim 1,
The inner core is formed of the same material as the water-soluble second material. According to claim 1,
The method of manufacturing an implant in which the inner core is formed of a single crystal of any one of sugar and salt. According to claim 1,
The method of manufacturing an implant in which the inner core is a capsule containing at least one of an antibiotic and a bleaching agent for skin discoloration treatment. According to claim 1,
The method of manufacturing an implant further comprising a fifth step of infiltrating the dried implant with any one of an antibiotic and a bleaching agent for treating skin discoloration. According to claim 2,
The second step,
a 2-1 step of assembling the mixed powder outside the inner core by rolling the inner core on the mixed powder; and
A 2-2 step of removing the remaining mixed powder by filtering the mixed powder and the inner core through a sieve having a predetermined size; According to claim 6,
The second step,
2-3 steps of heat-treating the assembled inner core and mixed powder;

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