KR20220150881A - 핵산 및 반감기 연장 모티프를 포함하는 화합물 - Google Patents

핵산 및 반감기 연장 모티프를 포함하는 화합물 Download PDF

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KR20220150881A
KR20220150881A KR1020227021677A KR20227021677A KR20220150881A KR 20220150881 A KR20220150881 A KR 20220150881A KR 1020227021677 A KR1020227021677 A KR 1020227021677A KR 20227021677 A KR20227021677 A KR 20227021677A KR 20220150881 A KR20220150881 A KR 20220150881A
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South Korea
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independently
unsubstituted
substituted
alkylene
compound
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Korean (ko)
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아서 티 서코우
찰스 앨러슨
파비오 씨 투씨
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디티엑스 파마, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
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KR1020227021677A 2019-11-26 2020-11-25 핵산 및 반감기 연장 모티프를 포함하는 화합물 Pending KR20220150881A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962940835P 2019-11-26 2019-11-26
US62/940,835 2019-11-26
PCT/US2020/062358 WO2021108662A1 (en) 2019-11-26 2020-11-25 Compound comprising a nucleic acid and a half-life extension motif

Publications (1)

Publication Number Publication Date
KR20220150881A true KR20220150881A (ko) 2022-11-11

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KR1020227021677A Pending KR20220150881A (ko) 2019-11-26 2020-11-25 핵산 및 반감기 연장 모티프를 포함하는 화합물

Country Status (11)

Country Link
US (1) US20230158150A1 (https=)
EP (1) EP4065172A1 (https=)
JP (1) JP7821737B2 (https=)
KR (1) KR20220150881A (https=)
CN (1) CN115397471B (https=)
AU (1) AU2020391218A1 (https=)
BR (1) BR112022009976A2 (https=)
CA (1) CA3161669A1 (https=)
IL (1) IL293341B1 (https=)
MX (1) MX2022006097A (https=)
WO (1) WO2021108662A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023039522A1 (en) * 2021-09-10 2023-03-16 Guardian Therapeutics, Llc Fatty acid conjugates of nucleic acids
EP4522742A2 (en) 2022-05-13 2025-03-19 Alnylam Pharmaceuticals, Inc. Single-stranded loop oligonucleotides
EP4709855A2 (en) 2023-05-12 2026-03-18 Alnylam Pharmaceuticals, Inc. Single-stranded loop oligonucleotides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2586704B1 (fr) * 1985-09-04 1987-12-18 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation et a un groupe chimique activable, leur synthese et leurs applications a titre de nucleases artificielles specifiques de sequences. centre national de la recherche scientifique (cnrs)
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
WO2015006740A2 (en) * 2013-07-11 2015-01-15 Alnylam Pharmaceuticals, Inc. Oligonucleotide-ligand conjugates and process for their preparation
US10588980B2 (en) * 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
EP3603648B1 (en) * 2017-03-29 2025-09-17 Shionogi & Co., Ltd Complex of nucleic acid medicine and multibranched lipid
CN120247995A (zh) * 2018-05-30 2025-07-04 诺华股份有限公司 脂质修饰的核酸化合物和方法

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Publication number Publication date
IL293341B1 (en) 2026-04-01
CN115397471B (zh) 2026-01-23
EP4065172A1 (en) 2022-10-05
JP2023503722A (ja) 2023-01-31
MX2022006097A (es) 2022-10-18
BR112022009976A2 (pt) 2022-10-04
JP7821737B2 (ja) 2026-02-27
CA3161669A1 (en) 2021-06-03
US20230158150A1 (en) 2023-05-25
IL293341A (en) 2022-07-01
AU2020391218A1 (en) 2022-06-02
WO2021108662A1 (en) 2021-06-03
CN115397471A (zh) 2022-11-25

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