KR20220140352A - vial device for containing exfoliative cells for smearing process - Google Patents

Abstract

The present invention relates to a technique regarding a vial device which stores a specimen including an exfoliative cell of a human body and smears the specimen. The present invention relates to a technique regarding a vial device, wherein the vial device is erected upside down in a state storing a specimen containing an exfoliative cell and a liquid medium therein such that an operation of smearing the exfoliative cell in the specimen on a surface of an external filter can be effectively performed. Specifically, the present invention relates to a technique regarding a vial device which is improved such that during a process of smearing an exfoliative cell on an external filter, a user operation of the vial device can be smoothly performed. According to the present invention, a plurality of cushion protruding members are provided on a membrane fixing member so as to increase the frictional force of an external grip member with respect to the vial device. Therefore, the external force can be accurately delivered to the vial device.

Description

Vial device for storing exfoliative cells for smearing {vial device for containing exfoliative cells for smearing process}

The present invention relates to a vial device for storing and smearing a specimen containing human decidual cells.

More specifically, the present invention can effectively perform the operation of smearing the decidual cells in the sample on the surface of the external filter as it stands upside down while storing the sample containing the decidual cells and liquid medium inside itself. It is a technology related to the vial device.

In particular, it relates to an improved type of vial device that can smoothly perform user manipulation of the vial device in the process of performing smearing of decidual cells on an external filter.

Usually, various screening processes can be performed through cell examination of the human body, one of which is to obtain decidual cells from a sample containing human decidual cells (eg, liquid medium and decidual cells) and then perform a cytological examination of the obtained decidual cells. More accurate observation and diagnosis of the decidual cells can be made possible by applying a thin smear on the slide of the deciduous cell.

However, in the prior art, the process of smearing on the slide of the cytology examination is not delicate, and as the decidual cells in the smeared state form an unspecified layer and overlap each other, the observation and diagnosis of decidual cells are lowered. there was

In contrast, recently, a vial device has been disclosed in which the specimen is stored, as well as deciduous cells are obtained directly from the stored specimen, and a smearing operation is possible.

However, this vial device also raises a problem that the structure needs to be improved enough to accommodate more precise external manipulation in the process of acquiring and smearing the specimen stored inside itself.

Accordingly, in the process of applying the smear on the upper surface of the filter by turning the vial device upside down, the structure is improved to the extent that the vial device can maintain a properly erected state by itself. this is required

The present invention has been proposed in view of the above, and an object of the present invention is to provide a vial device for storing decidual cells for smearing that can be maintained in an inverted position that is stable enough to keep the vial in an upright state by itself during smearing. is in providing.

In addition, an object of the present invention is to provide a vial device for storing deciduous cells for smearing, which can improve frictional force with respect to an external grip member to enable accurate external force transmission to the vial during smearing.

In order to achieve the above object, the vial device for storing decidual cells for smearing according to the first embodiment of the present invention has an entrance and exit passage for internal and external access at the upper end so as to contain the decidual cells and the liquid medium of the decidual cells. provided container member 110; Membrane fixing member 120 which is mounted on the rim of the container member corresponding to the entry and exit passage as a hollow cap formed through the central portion, and whose outer diameter is maintained uniformly in the vertical vertical direction from the upper end to the lower end; When the container member is erected upside down so that the access passage faces downward as it is made of a porous membrane and its edge is connected to the inner wall of the central part formed through the membrane fixing member, it blocks the downward fall of the deciduous cells and the liquid medium in the container member, a porous permeable membrane member 130 for discharging a portion of the liquid medium and decidual cells in the container member in the downward direction when an external force is applied in a state in which the container member is upside down; As it is detachably connected to the through-formed portion of the membrane fixing member, the opening/closing cap member 140 blocks the entry and exit of the container member through the porous permeable membrane member.

In addition, the opening/closing cap member 140 includes a depression member 141 which is recessed downwardly in the center of its upper surface; One or more locking rib members 142 erected on the inside of the recessed member in the form of connecting the inner wall and the inner wall of the recessed member, the rotary member is rotated when the external rotary member is rotated while being fitted in the recessed member The opening/closing cap member may be configured to be separated from the membrane fixing member by being caught by the locking rib member.

In addition, the container member 110 includes an inwardly stepped member 111 that is cut inwardly along its rim from its lower outer surface, so that the grip member is in a state in which the external grip member grips the container member. It may be configured to be draped over the inwardly stepped member.

On the other hand, according to the second embodiment of the present invention, the membrane fixing member 120 is a plurality of cushion protrusion members 122 that are disposed to be spaced apart from each other by a predetermined distance along the edge of the membrane fixing member 120 vertically protruding from its outer surface in the vertical direction. ); may be provided.

The present invention shows the advantage of being able to stably maintain the erected state of the container member in an erected state for the smearing operation by having the membrane fixing member of an improved structure.

In addition, the present invention is provided with a plurality of cushion protruding members in the membrane fixing member to improve the frictional force of the external grip member with respect to the vial during the smearing operation, it also shows the advantage that it is possible to accurately transmit the external force to the vial.

[Figure 1] is a front view showing a vial device according to a first embodiment of the present invention,
[Figure 2] is a perspective view showing a vial device according to a first embodiment of the present invention,
[FIG. 3] is a diagram showing each configuration separately in [FIG. 2],
[FIG. 4] is a view of [FIG. 3] viewed from another angle,
[FIG. 5] is a cross-sectional view of the state excluding the cap member in [FIG. 2],
[FIG. 6] is a view of [FIG. 5] viewed from another angle,
[FIG. 7] is a front view of [FIG. 6],
[FIG. 8] is an exemplary view showing the process in which the porous permeable membrane member approaches the filter member by inverting [FIG. 7];
[FIG. 9] is an exemplary view showing a state in which the porous permeable membrane member is in contact with the filter member in [FIG. 8];
[Figure 10] is a front view and a partially enlarged view showing a vial device according to a second embodiment of the present invention;
[FIG. 11] is a perspective view and a partially enlarged view showing a vial device according to a second embodiment of the present invention;
[FIG. 12] is a view showing each configuration separated from [FIG. 11] and a partially enlarged view,
[FIG. 13] is a view and a partial enlarged view of [FIG. 12] viewed from another angle.

Hereinafter, the present invention will be described in detail with reference to the drawings.

[Figure 1] is a front view showing the vial device according to the first embodiment of the present invention, [Figure 2] is a perspective view showing the vial device according to the first embodiment of the present invention, [Figure 3] is [ 2] is a view showing each configuration separately, [Fig. 4] is a view viewed from a different angle [Fig. 3], [Fig. 5] is a cross-sectional view of the state excluding the cap member in [Fig. 2] , [FIG. 6] is a view viewed from another angle of [FIG. 5], [FIG. 7] is a front view of [FIG. 6], and [FIG. 8] is [FIG. 7] inverted so that the porous permeable membrane member filters It is an exemplary view showing the process of approaching the member, [FIG. 9] is an exemplary view showing the state in which the porous permeable membrane member is in contact with the filter member in [FIG. 8].

1 to 7, the vial device for storing deciduous cells for smearing according to the present invention is a container member 110, a membrane fixing member 120, a porous permeable membrane member 130, opening and closing The cap member 140 may be included.

The container member 110 may be provided with a passageway for internal and external access at the upper end to contain the decidual cells and the liquid medium of the decidual cells, as shown in FIGS. 3 to 7 . In addition, the container member 110 may include an inward stepped member 111 and an outward stepped member 112 .

First, the inward step member 111 may be inwardly cut along the rim of the container member 110 body from the lower outer surface of the body of the container member 110 as shown in FIGS. 1 to 9 .

As a result, in a state in which an external grip member (not shown) grips the container member 110 , the grip member may span the recessed portion of the inwardly stepped member 111 , thereby gripping the container member 110 . It is possible to prevent the grip member from sliding from the container member 110 through the inwardly stepped member 111 in one state.

And, the outward step member 112 may be formed to protrude along the rim on the outer surface of the container member 110 body, as in [FIG. 1] to [FIG. 9].

As a result, when the membrane fixing member 120 is connected to the container member 110 by screwing, for example, the lower end of the membrane fixing member 120 is the upper end of the outwardly stepped member 112 on [ FIGS. 1 ] to [ FIG. 4 ]. As it comes into contact with the container member 110, the degree of screwing of the membrane fixing member 120 is guided.

Here, the 'sample' consists of a liquid component of the human body from a component obtained from the human body and several decidual cells mixed in the liquid component. In addition, the liquid component was expressed as a liquid medium for the decidual cells in that the several decidual cells interfaced so that they could be mixed with each other or floating.

In addition, the 'sample' may include by-products obtained from the human body in addition to decidual cells and liquid medium.

The membrane fixing member 120 is a hollow cap through which the central part is formed as shown in [Figs. have.

In addition, the membrane fixing member 120 may be uniformly maintained in the vertical vertical direction from the upper end to the lower end as shown in [Fig. 1] to [Fig. 4]. As a result, the container member 110 is supported by the support member so that the porous permeable membrane member 130 is adjacent to the filter member 10 in a state in which the container member 110 is upside down as in FIGS. 8 and 9 . When disposed as in [Fig. 9] with respect to (20), the erected state of the container member 110 may be stably maintained.

Here, as the outer diameter of the membrane fixing member 120 maintains a uniform outer diameter in the vertical vertical direction from the upper end to the lower end of the membrane fixing member 120 as in [Fig. 1] to [Fig. 4], [Fig. 9] and When disposed together, the erected state of the container member 110 can be stably maintained. Strictly, in the local portion of the upper edge of the membrane fixing member 120 and the local portion of the lower edge of the membrane fixing member 120 [FIG. 1] to [FIG. 4] As in ], it is rounded in the form of a so-called fillet.

As such, the degree of rounding of the local portion of the upper edge of the membrane fixing member 120 and the local portion of the lower edge of the edge of the membrane fixing member 120 as in [FIG. 1] to [FIG. It is preferable to remove only the degree and not to prevent the standing state of the container member 110 from being stably maintained when it is disposed as shown in [FIG. 9].

The porous permeable membrane member 130 is made of a porous membrane capable of filtering the contents while permeating the liquid with respect to the contents (eg, decidual cells) mixed with the liquid, and its edge is [FIG. 3] to [ 7], it may be connected to the inner wall of the central portion formed through the membrane fixing member 120 .

As a result, when the container member 110 is upside down as in [FIG. 8] and [FIG. 9] so that the access passage of the container member 110 faces downward, the deciduous cells and the liquid medium in the container member 110 are can block the downward fall of

At this time, when an external force is applied in a state in which the container member 110 is upside down as shown in FIG. 9 , the deciduous cells and a portion of the liquid medium in the container member 110 may be discharged downward.

Here, since the membrane fixing member 120 supporting the porous permeable membrane member 130 maintains a state connected to the container member 110, the sample is contained inside the container member 110 [FIG. 8] When the container member 110 is upside down as in and [FIG. 9], the porous permeable membrane member 130 can maintain its current position despite the sample load in the container member 110 without being separated downward. there will be

Meanwhile, the membrane fixing member 120 may include an inner bridge member 121 connected to the inner wall along its inner wall edge as shown in FIGS. 3 and 5 to 9 . In this case, the porous permeable membrane member 130 may preferably be integrally fixed to the inner wall of the inner bridge 131 as shown in [Fig. 3] and [Fig. 5] to [Fig. 9].

In addition, the inner bridge member 121 may be elastically connected from the body of the membrane fixing member 120 preferably.

As a result, when an external force is applied from the bottom to the porous permeable membrane member 130 in a state in which the container member 110 in a state containing the sample inside is upside down as in [FIG. 8] and [FIG. 9], the inner bridge Due to the elastic force of the member 121 , the magnitude of the external force applied to the connection portion between the membrane fixing member 120 and the porous permeable membrane member 130 may be reduced.

Meanwhile, the membrane fixing member 120 may be detachably connected to the rim of the container member 110 to form a double cap structure together with the opening/closing cap member 140 as shown in FIGS. 3 to 7 .

Here, when the membrane fixing member 120 is separated from the container member 110 , a separate suction unit (not shown) provided in the external decidual cell processing apparatus is installed through the container member 110 through the access passage of the container member. The sample contained in the container member 110 can be sucked while entering and exiting in the vertical direction with respect to 110 .

At this time, the container member 110 is preferably made of a hollow cylindrical shape so that the suction unit can smoothly enter and exit the inside and outside of the container member 110 without any jamming, and the inner wall may be flat.

The opening/closing cap member 140 is detachably connected to the through-formed portion of the membrane fixing member 120 as shown in FIGS. 1 to 4 , and thus the container member 110 through the porous permeable membrane member 130 . blocking the entry and exit of

And, the opening/closing cap member 140 is a porous permeable membrane member 130 integrally connected to the membrane fixing member 120 as it is separated from the membrane fixing member 120 as in [FIG. 3] to [FIG. 9]. It is exposed to the outside as in [FIG. 3] to [FIG. 9].

In addition, the opening/closing cap member 140 includes a depression member 141 dented downward in the center of its upper surface, and one connected to the inner wall of the depression member 141 while standing inside the depression member 141 . The above locking rib member 142 may be provided.

At this time, when the external rotating member (not shown) rotates while being fitted in the recessed member 141 , the rotating member is caught by the engaging rib member 142 and the opening/closing cap member 140 rotates from the membrane fixing member 120 . As a result, it is separated from the membrane fixing member 130 .

As a result, as the opening/closing cap member 140 is separated from the membrane fixing member 120 as shown in FIGS. 3 to 7 , the porous permeable membrane member 130 integrally connected to the membrane fixing member 120 . may be exposed to the outside.

[Fig. 10] is a front view and a partially enlarged view of a vial device according to a second embodiment of the present invention, and [Fig. 11] is a perspective view and partially enlarged view showing a vial device according to a second embodiment of the present invention. Fig. 12 is a view and a partially enlarged view showing each configuration separated in [Fig. 11], and [Fig. 13] is a view and a partially enlarged view of [Fig. 12] viewed from different angles.

In the vial device according to the second embodiment of the present invention, the membrane fixing member 120 may include a plurality of cushion protruding members 122 as shown in FIGS. 10 to 13 preferably.

The cushion protrusion member 122 protrudes vertically from the outer surface of the membrane fixing member 120 in the vertical direction as shown in FIGS. Thus, a plurality may be disposed.

As such, as the plurality of cushion protrusion members 122 are provided along the outer surface edge of the membrane fixing member 120, the frictional force of the grip member (not shown) with respect to the vial device during the smearing operation can be improved, thereby Accurate external force transmission to the vial device is possible.

If, as in [Fig. 9], when the porous permeable membrane member 130 maintains a state adjacent to the filter member 10 in a state in which the vial device is upside down as in [Fig. If the gripping state is maintained, the durability of the porous permeable membrane member 130 is maintained when a certain amount of movement can be maintained between the membrane fixing member 120 and the grip member by the tension of the cushion protruding member 122 . It might be possible.

Here, the position for gripping the vial device may be the inward stepped member 111 of the container member 110 or the membrane fixing member 120 depending on the grip position in the decidual cell processing device and the grip position required for smearing. It can also be the outer surface of the border.

10: no filter
20: support member
110: container member
111: no inward step difference
112: no outward step
120: membrane fixing member
121: inner bridge member
122: cushion protrusion member
130: porous permeable membrane member
140: opening and closing cap member
141: no depression
142: locking rib member

Claims (4)

A container member 110 provided with an access passage for entering and leaving the decidual cells and the liquid medium of the decidual cells at the upper end;
A hollow cap having a central portion formed therethrough, the membrane fixing member 120 is mounted on the rim of the container member corresponding to the access passage and its outer diameter is maintained uniformly in the vertical vertical direction from the upper end to the lower end;
When the container member is made of a porous membrane and its edge is connected to the inner wall of the central part formed through the membrane fixing member, when the container member is upside down so that the access passage faces downward, the deciduous cells and the liquid medium in the container member A porous permeable membrane member 130 for blocking the fall and discharging a portion of the liquid medium and deciduous cells in the container member in the downward direction when an external force acts in a state in which the container member is upside down;
an opening/closing cap member 140 for blocking the entry and exit of the container member through the porous permeable membrane member as it is detachably connected to the through-formed portion of the membrane fixing member;
A vial device for storing decidual cells for smearing, comprising a.
The method according to claim 1,
The membrane fixing member 120,
A plurality of cushion protrusion members 122 that protrude vertically from their outer surface and are disposed to be spaced apart from each other by a predetermined distance along their rims;
A vial device for storing decidual cells for smearing, characterized in that it comprises a.
The method according to claim 1 or 2,
The opening and closing cap member 140,
a depression member 141 that is recessed downwardly in the center of its upper surface;
one or more engaging rib members 142 erected on the inner side of the recessed member in a form for connecting the inner wall and the inner wall of the recessed member;
provided with
Deciduous cell storage for smearing, characterized in that when an external rotating member rotates while being fitted in the recessed member, the rotating member is caught by the locking rib member and the opening/closing cap member is separated from the membrane fixing member for vial devices.
4. The method of claim 3,
The container member 110,
an inwardly stepped member 111 formed inwardly along its rim from its lower outer surface;
provided with
A vial device for storing deciduous cells for smearing, characterized in that the grip member can be draped over the inwardly stepped member while the external grip member grips the container member.

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