KR20220138388A - Cd28 돌연변이를 갖는 키메라 항원 수용체 및 그의 용도 - Google Patents

Cd28 돌연변이를 갖는 키메라 항원 수용체 및 그의 용도 Download PDF

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KR20220138388A
KR20220138388A KR1020227029292A KR20227029292A KR20220138388A KR 20220138388 A KR20220138388 A KR 20220138388A KR 1020227029292 A KR1020227029292 A KR 1020227029292A KR 20227029292 A KR20227029292 A KR 20227029292A KR 20220138388 A KR20220138388 A KR 20220138388A
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seq
car
gly
ser
cells
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앤서니 다니얀
레니어 제이. 브렌트젠스
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메모리얼 슬로안 케터링 캔서 센터
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
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    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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KR1020227029292A 2020-02-05 2021-02-05 Cd28 돌연변이를 갖는 키메라 항원 수용체 및 그의 용도 Pending KR20220138388A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062970401P 2020-02-05 2020-02-05
US62/970,401 2020-02-05
PCT/US2021/016713 WO2021158850A1 (en) 2020-02-05 2021-02-05 Chimeric antigen receptors with cd28 mutations and use thereof

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KR20220138388A true KR20220138388A (ko) 2022-10-12

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KR1020227029292A Pending KR20220138388A (ko) 2020-02-05 2021-02-05 Cd28 돌연변이를 갖는 키메라 항원 수용체 및 그의 용도

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US (1) US20230051064A1 (https=)
EP (1) EP4100025A4 (https=)
JP (2) JP7698655B2 (https=)
KR (1) KR20220138388A (https=)
CN (1) CN115397461A (https=)
AU (1) AU2021216450A1 (https=)
BR (1) BR112022015529A2 (https=)
CA (1) CA3170706A1 (https=)
IL (1) IL295405B1 (https=)
MX (1) MX2022009704A (https=)
WO (1) WO2021158850A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114031690B (zh) * 2021-12-03 2022-07-15 广州百暨基因科技有限公司 靶向ccr1和nkg2d配体的嵌合抗原受体及其应用
EP4630537A1 (en) 2022-12-07 2025-10-15 Fondazione Matilde Tettamanti e Menotti de Marchi Onlus Methods for generating genetically modified cytokine induced killer (cik) cells
EP4382118B1 (en) * 2022-12-07 2025-08-20 Eberhard Karls Universität Tübingen, Medizinische Fakultät Modified immune cell
WO2025084881A1 (ko) * 2023-10-20 2025-04-24 주식회사 이온셀 Ct83 항원에 결합하는 car-t 세포 및 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525503A (en) * 1993-09-28 1996-06-11 Dana-Farber Cancer Institute, Inc. Signal transduction via CD28
AU2002220265A1 (en) * 2000-11-03 2002-05-15 University Of Vermont And State Agricultural College Compositions for inhibiting grb7
US9096663B2 (en) * 2001-02-15 2015-08-04 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating conditions related to ephrin signaling with cupredoxins and mutants thereof
EP4012714A1 (en) * 2010-03-23 2022-06-15 Iogenetics, LLC. Bioinformatic processes for determination of peptide binding
CN109069537B (zh) * 2016-04-04 2022-04-15 亘喜生物科技（上海）有限公司 共刺激结构域中具有重复结合基序的car
ES2912408T3 (es) * 2017-01-26 2022-05-25 Novartis Ag Composiciones de CD28 y métodos para terapia con receptores quiméricos para antígenos
KR20200027508A (ko) * 2017-07-07 2020-03-12 에이치 리 모피트 캔서 센터 앤드 리서어치 인스티튜트 아이엔씨 돌연변이된 cd28 공동자극 도메인을 갖는 키메라 항원 수용체

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JP2023514148A (ja) 2023-04-05
JP7698655B2 (ja) 2025-06-25
BR112022015529A2 (pt) 2022-12-13
MX2022009704A (es) 2022-11-08
JP2025085754A (ja) 2025-06-05
CN115397461A (zh) 2022-11-25
IL295405B1 (en) 2026-04-01
CA3170706A1 (en) 2021-08-12
AU2021216450A1 (en) 2022-09-08
WO2021158850A1 (en) 2021-08-12
IL295405A (en) 2022-10-01
EP4100025A1 (en) 2022-12-14
EP4100025A4 (en) 2025-03-05
US20230051064A1 (en) 2023-02-16

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