KR20220138160A - Multi-wavelength LED catheter for photodynamic and photothermal therapy - Google Patents

Abstract

The present invention provides a multi-wavelength LED catheter for a photodynamic and photothermal treatment comprising: a catheter main body of a polygonal column form having a polygonal cross-section; micro-LEDs each attached to each side surface of the catheter main body; and encapsulation parts each attached to each side surface of the catheter main body to cover and encapsulate the micro-LEDs. Therefore, the present invention is capable of enabling a size of the catheter to be much more miniaturized.

Description

Multi-wavelength LED catheter for photodynamic and photothermal therapy

Embodiments of the present invention relate to multi-wavelength LED flexible catheters for photodynamic and photothermal therapy.

The duodenum is the site of increased secretion of type 2 diabetes/nonalcoholic fatty liver-related hormones (eg GIP) during abnormal mucosal thickening in patients with type 2 diabetes. It is a key position in treatment. For the treatment of these diseases, duodenal mucosal resurfacing has been applied. The duodenal mucosal resurfacing procedure can be used to treat metabolic diseases such as type 2 diabetes, obesity and nonalcoholic fatty liver by inducing regeneration of the pancreas by applying photothermal treatment to the duodenal surface using LED heat.

Meanwhile, photodynamic therapy (PDT) is based on the administration of a photoreactive agent, a photo-initiating agent, or a photosensitizing agent, a specific wavelength or waveband ) is a process in which light is directed toward a photosensitive target cell.

One type of light delivery system used for photodynamic therapy involves the delivery of light from a light source, such as a laser, to target cells, using a single fiber delivery system with a specific light-diffusing tip. In another version, the light source used for photodynamic therapy may also be a light emitting diode (LED). For example, it can be used for photodynamic therapy by forming a light bar for arranging LEDs.

An object of the present invention is to provide a multi-wavelength LED flexible catheter that can perform photodynamic therapy and photothermal therapy together.

However, these problems are exemplary, and the scope of the present invention is not limited thereto.

Multi-wavelength LED catheter for photodynamic and photothermal therapy according to an embodiment of the present invention, having a polygonal cross-section, a catheter body in the form of a polygonal column; LEDs respectively attached to each side of the catheter body; and encapsulation units respectively attached to each side of the catheter body to cover and encapsulate the LED.

According to one embodiment, an LED emitting light of one wavelength band is attached to one side of the catheter body, and an LED emitting light of another wavelength band is attached to the other side of the catheter body.

According to an embodiment, an LED emitting light of a first wavelength band and an LED emitting light of a second wavelength band may be alternately attached to the first side of the catheter body.

According to one embodiment, the second side of the catheter body, the LED emitting the light of the second wavelength band and the LED emitting the light of the third wavelength band may be alternately attached.

According to an embodiment, the first wavelength band is a predetermined wavelength band between 500 and 600 nm, the second wavelength band is a predetermined wavelength band between 600 and 700 nm, and the third wavelength band is a predetermined wavelength band between 800 and 900 nm. may be in the wavelength band of

According to one embodiment, the temperature of the photothermal treatment may be controlled based on a ratio of the number of LEDs emitting light of the second wavelength band and the number of LEDs emitting light of the third wavelength band.

According to one embodiment, it is possible to control the temperature of the photothermal treatment based on the irradiation time of the number of LEDs emitting light of the second wavelength band and the irradiation time of the LED emitting light of the third wavelength band.

According to one embodiment, the catheter body may be formed with a guide hole for the guide wire to pass through and a wiring hole for placing the LED wire. Through these guide wires, various digestive organs are accessed and treated through the digestive lumen including the bile duct and pancreatic duct.

According to one embodiment, a protective cap is disposed on the front end of the catheter body, a hole connected to the guide hole is formed in the protective cap, and the protective cap may seal and cover the wiring hole.

Other aspects, features and advantages other than those described above will become apparent from the following drawings, claims, and detailed description of the invention.

According to an embodiment of the present invention made as described above, photothermal treatment and photodynamic treatment can be simultaneously performed using a multi-wavelength light source, and can be selectively or uniformly performed for each region.

In addition, unlike a general cylindrical catheter, by using a polygonal columnar catheter having a flat side, mini or micro LED transfer is easy to facilitate manufacturing, and the size of the catheter can be much reduced.

Of course, the scope of the present invention is not limited by these effects.

1 is a schematic diagram of a multi-wavelength LED catheter 100 in accordance with one embodiment of the present invention.
FIG. 2 is an enlarged view of the distal end of the multi-wavelength LED catheter 100 shown in FIG. 1 .
3 shows a state in which the encapsulation part 120 and the protective cap 121 are removed in an enlarged view of the distal end of the multi-wavelength LED catheter 100 shown in FIG. 1 .
4 is a view for explaining the light emitted by the LEDs disposed on each side in the multi-wavelength LED catheter 100 according to an embodiment of the present invention.
5 is a view for explaining the light emitted by the LEDs disposed on each side in the multi-wavelength LED catheter 100 according to another embodiment of the present invention.
6 is a schematic diagram of a multi-wavelength LED catheter 200 according to another embodiment of the present invention.
FIG. 7 is an enlarged view of the distal end of the multi-wavelength LED catheter 200 shown in FIG. 6 .
8 to 10 are views for explaining a method of manufacturing a multi-wavelength LED catheter according to an embodiment of the present invention.

Since the present invention can apply various transformations and can have various embodiments, specific embodiments are illustrated in the drawings and described in detail in the detailed description. Effects and features of the present invention, and a method for achieving them, will become apparent with reference to the embodiments described below in detail in conjunction with the drawings. However, the present invention is not limited to the embodiments disclosed below and may be implemented in various forms.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings, and when described with reference to the drawings, the same or corresponding components are given the same reference numerals, and the overlapping description thereof will be omitted. .

In the following embodiments, terms such as first, second, etc. are used for the purpose of distinguishing one component from another, not in a limiting sense.

In the following examples, the singular expression includes the plural expression unless the context clearly dictates otherwise.

In the following embodiments, terms such as include or have means that the features or components described in the specification are present, and the possibility that one or more other features or components may be added is not excluded in advance.

In the drawings, the size of the components may be exaggerated or reduced for convenience of description. For example, since the size and thickness of each component shown in the drawings are arbitrarily indicated for convenience of description, the present invention is not necessarily limited to the illustrated bar.

In the following embodiments, when it is said that a part such as a component is on or on another part, it includes not only a case where it is directly on the other part but also a case where another component is interposed therebetween.

In the following embodiments, when components are connected, it includes not only cases in which components are directly connected but also cases in which other components are interposed between components and connected indirectly.

1 is a schematic diagram of a multi-wavelength LED catheter 100 in accordance with one embodiment of the present invention. FIG. 2 is an enlarged view of the distal end of the multi-wavelength LED catheter 100 shown in FIG. 1 . 3 shows a state in which the encapsulation part 120 and the protective cap 121 are removed in an enlarged view of the distal end of the multi-wavelength LED catheter 100 shown in FIG. 1 .

1 to 3, the multi-wavelength LED catheter 100 includes a catheter body 110, a micro LED 150 attached to the side of the catheter body 110, and an encapsulation unit 120 covering the micro LED. include The multi-wavelength LED catheter 100 may be connected to an external control device 130 .

In the embodiment of the present invention, the catheter body 110 is not a cylindrical shape, but a flexible polygonal column shape. Accordingly, the catheter body 110 has a polygonal cross-section. That is, the cross section perpendicular to the longitudinal direction of the catheter body 110 is polygonal. The catheter body 110 may be formed of, for example, a flexible material such as polyurethane, and may have a diameter of 1-2 mm.

1 to 3, a catheter in the form of a triangular prism is shown. However, the present invention is not limited thereto, and the catheter according to various embodiments may be in the form of a quadrangular prism or a pentagonal prism.

Since the catheter body 110 is in the form of a polygonal column, the side surface of the catheter body 110 may be composed of a plurality of divided planes. Here, since the catheter body 110 may be configured to be flexible, each side is not always in a perfectly flat state, and may include a flexible bent state in the longitudinal direction. However, the meaning that the side surface of the catheter body 110 is composed of a plurality of divided planes means that the catheter body 110 can be formed of a plurality of divided planes corresponding to the sides of the polygonal pole in a straight state. to be.

A micro LED 150 is attached to the side of the catheter body 110 . The micro LED 150 may be arranged along the longitudinal direction from the tip side of the catheter 100 . Micro LED 150 may be attached to both sides of the catheter body 110 . Here, the micro LED 150 may include an LED having a size of 5 to 100 μm, but the present invention is not limited thereto, and may include a mini LED having a size of 100 to 200 μm. The micro LED 150 may be a micro LED patch. Although not shown, the micro LED 150 may be connected to a driving control circuit and a thin film battery.

In one embodiment, when the catheter body 110 has a triangular prism shape, the catheter body 110 may have a first side, a second side, and a third side. The micro LED 150 may be attached to each of the first side, the second side, and the third side.

In various embodiments of the present invention, a plurality of micro LEDs 150 attached to a plurality of sides of the catheter body 110 may emit light of various wavelengths. For example, among the plurality of micro LEDs 150 , some may emit light in a first wavelength band, and some may emit light in a second wavelength band. For another example, some of the plurality of micro LEDs 150 may emit light of a first wavelength band, some may emit light of a second wavelength band, and some may emit light of a third wavelength band. However, the present invention is not limited thereto.

In various embodiments, the first wavelength band is a predetermined wavelength band between 500 and 600 nm, the second wavelength band is a predetermined wavelength band between 600 and 700 nm, and the third wavelength band is a predetermined wavelength band between 800 and 900 nm. can However, the present invention is not limited thereto.

The first micro LED of the first wavelength band can have a low output, and the light of the first wavelength band has excellent absorption power to the red light sensitive agent. Therefore, light in the first wavelength band can be used for selective treatment through photodynamic therapy. In some cases, a combination of the first wavelength band and the second wavelength band may be used for photodynamic therapy.

The second micro LED in the second wavelength band has low light efficiency and a relatively high surface temperature, so it is easy for photothermal treatment. Therefore, light in the second wavelength band may be used for photothermal therapy, and in some cases, a combination of light in the second wavelength band and light in the third wavelength band may be used for photothermal therapy.

Light in the third wavelength band has high penetrating power compared to energy efficiency and good light efficiency, so it can penetrate deep tissues and be used for cell therapy, and the effect of photothermal therapy can be maximized. For example, when the multi-wavelength LED catheter 100 is inserted into the duodenum, the light of the third wavelength band penetrates to the pancreas near the duodenum, and can be used for cell therapy and regeneration of the pancreas.

4 is a view for explaining the light emitted by the micro LEDs disposed on each side in the multi-wavelength micro LED catheter 100 according to an embodiment of the present invention.

Referring to FIG. 4 , according to an embodiment of the present invention, first micro LEDs 150 emitting light L1 of a first wavelength band are attached to the first side of the catheter body 110, and the catheter body 110 ) is attached to the second side of the second microLED 150 that emits light L2 of the second wavelength band, and the third side of the catheter body 110 emits light (not shown) of the third wavelength band. Third micro LEDs 150 may be attached thereto.

In this case, the light L1 of the first wavelength band is emitted from the first side of the LED catheter 100, the light L2 of the second wavelength band is emitted from the second side, and the light of the third wavelength band is emitted from the third side (not shown). city) is released. In other words, the LED catheter 100 according to this embodiment irradiates the light L1 of the first wavelength band in the first direction, the light L2 of the second wavelength band in the second direction, and the third side The light of the third wavelength band may be irradiated in the third direction to be viewed.

According to this embodiment, by selectively distributing or dividing wavelength bands of light irradiated in each direction, it is possible to maximize the treatment effect for each wavelength band in each direction. For example, the light of the third wavelength band having high penetrating power may be irradiated in the direction in which the pancreas is located so as to contribute to the treatment of cells of the pancreas. In this case, the LED catheter 100 may be oriented so that the above-described third side faces the direction in which the pancreas is located.

5 is a view for explaining the light emitted by the micro LEDs disposed on each side in the multi-wavelength LED catheter 100 according to another embodiment of the present invention.

Referring to Figure 5, according to another embodiment of the present invention, a first micro LED emitting light (L1) of a first wavelength band and a light (L2) of a second wavelength band are provided on the first side of the catheter body 110 Emitting second micro LEDs may be alternately attached.

The second microLED emitting the light L2 of the second wavelength band and the third micro LED emitting the light L3 of the third wavelength band may be alternately attached to the second side of the catheter body 110 . Although not shown, the third side of the catheter body 110 is similarly, according to the embodiment, different micro LEDs emitting light of different wavelength bands may be alternately disposed.

For example, referring to FIG. 3 , the first micro LED 150-1, the second micro LED 150-2, and the third micro LED on the first side of the catheter body 110 in the LED catheter 100 ( 150-3) and a fourth micro LED (not shown) may be sequentially arranged. According to the embodiment described in FIG. 5 , the first micro LED 150-1 emits light L1 in a first wavelength band, and the second micro LED 150-2 emits light L2 in the second wavelength band. , the third micro LED 150 - 3 may emit light L1 of the first wavelength band, and the fourth micro LED (not shown) may emit light L2 of the second wavelength band.

According to this embodiment, light of various wavelength bands may be uniformly irradiated in each direction. For example, light irradiated in one direction may have a dual wavelength band, and a dual treatment effect according to the dual wavelength band may be exhibited.

For example, the first aspect in which the first micro LEDs in the first wavelength band between 500 and 600 nm and the second micro LEDs in the second wavelength band between 600 and 700 nm are alternately arranged may be used for intensive treatment (eg, photodynamic therapy) and photothermal treatment at the same time.

For another example, the second side in which the second micro LED in the second wavelength band between 600 and 700 nm and the third micro LED in the third wavelength band between 800 and 900 nm are alternately arranged, the photothermal treatment can be performed through precise temperature control. can be done effectively. In the second aspect, temperature control can be precisely controlled by arranging the third microLED in the third wavelength band having high light efficiency and the second microLED in the second wavelength band having low light efficiency in a predetermined ratio. For example, the number of micro LEDs in the second wavelength band and the number of micro LEDs in the third wavelength band disposed on the second side of the LED catheter 100 according to the embodiment may have a specified ratio. For example, the second microLED of the second wavelength band and the third microLED of the third wavelength band may be arranged on the second side in a ratio of 1:1, 1:2, or 2:3. For another example, the temperature may be controlled by controlling the irradiation time of the second microLED of the second wavelength band and the third microLED of the third wavelength band, respectively. The irradiation time of the second wavelength band, which generates a lot of heat due to low light efficiency, may be set shorter than the irradiation time of the third wavelength band. According to the set irradiation time, the micro LED of the second and third wavelength bands may be repeatedly turned on/off.

In addition, when using a combination of the second micro LED of the second wavelength band and the third micro LED of the third wavelength band compared to the case of using only the second micro LED of the second wavelength band, the penetration power is better and the depth and efficiency of photothermal treatment this could be better

Referring back to FIGS. 1 to 3 , a guide hole 112 may be formed in the catheter body 110 in the longitudinal direction. A guide wire 140 may pass through the guide hole 112 . A diameter of the guide wire 140 may be about 0.025 inches, and a movement space of the guide wire 140 may be secured through the guide hole 112 . The procedure using the endoscope is possible through the guide wire 140 and the guide hole 112 .

A wiring hole 111 may be formed in the catheter body 110 in the longitudinal direction. Through this, the LED wiring may be located inside the wiring hole 111 , that is, the catheter body 110 . The wiring hole 111 is separated from the guide hole 112 .

On each side of the multi-wavelength catheter body 110, an encapsulation portion 120 for covering and encapsulating the micro LED may be formed.

The encapsulation unit 120 may be formed on each side of the catheter body 110 . For example, when the catheter body 110 is a triangular prism shape, the encapsulation unit 120 is a first encapsulation unit 120-1 for encapsulating the micro LEDs attached to the first side of the catheter body 110, the first It may be composed of a second encapsulation unit 120-2 for encapsulating the micro LEDs attached to the second side, and a third encapsulation unit 120-3 for encapsulating the micro LEDs attached to the third side. The encapsulation unit 120 may be formed of, for example, silicon packaging to protect the micro LED catheter 100 . The encapsulation unit 120 may allow light of the first, second, and third wavelength bands to pass therethrough, and may be transparent, for example.

The distal end of the catheter body 110 may be covered with a protective cap 121 . The protective cap 121 may be formed of, for example, the same material as the encapsulation unit 120 , but is not limited thereto. A hole 122 connected to the guide hole 112 through which the guide wire 140 may pass may be formed in the protective cap 121 . That is, the guide hole 112 formed in the catheter body 110 and the hole 122 formed in the protective cap 121 may be connected, and the guide wire 140 passes through the guide hole 112 and the hole 122 . and can move

The protective cap 121 may cover or seal the wiring hole 111 so that the wiring hole 111 in which the micro LED wiring is disposed is not exposed to the outside.

As another embodiment, a micro LED may be further attached to the tip of the catheter body 110 . In other words, by using the micro LED disposed at the tip of the catheter body 110, photothermal and photodynamic therapy can be performed not only in the lateral direction of the catheter body 110 but also in the front. In this case, the protective cap 121 may cover and protect the micro LED.

According to an embodiment of the present invention, by configuring the catheter body 110 of the LED catheter 100 in the form of a polygonal column, each side of the catheter body 110 can correspond to a plane, and thus micro LED ( 150) the transcription process can be very easy. In general, since the existing micro LED catheter has a small diameter cylindrical shape, the micro LED had to be attached to the catheter by hand. In addition, there was a limit to reducing the diameter of the existing cylindrical micro LED catheter.

On the other hand, according to the embodiment of the present invention, after growing the micro LED on the growth substrate, there is an advantage that can be transferred (transfer) to each side of the catheter body 110 according to the present invention in a batch. That is, the micro LED catheter 100 in the form of a polygonal column according to the present invention very facilitates the micro LED transfer, so it may be possible to miniaturize using a mini micro LED or micro LED.

On the other hand, the manufacturing method of the multi-wavelength LED catheter 100 according to the embodiment of the present invention, after growing the micro LED on the growth substrate, transferring the micro LED to the catheter body 110, separating the growth substrate, the catheter encapsulating each side of the body 110, respectively. More details will be described later.

6 is a schematic diagram of a multi-wavelength LED catheter 200 according to another embodiment of the present invention. FIG. 7 is an enlarged view of the distal end of the multi-wavelength LED catheter 200 shown in FIG. 6 .

Compared with the above-described multi-wavelength LED catheter 100, the multi-wavelength LED catheter 200 of FIGS. 6 and 7 is only a difference in that it is in the form of a pentagonal column, so only the difference will be described.

Multi-wavelength LED catheter 200 according to another embodiment of the present invention, the catheter body 210 in the form of a pentagonal column, micro LEDs attached to each side of the catheter body 210, respectively, cover and encapsulate the micro LEDs It includes an encapsulation unit 220 that is respectively attached to each of the side surfaces. The multi-wavelength LED catheter 200 may be connected to an external control device 230 .

When the LED catheter 200 is in the form of a pentagonal column, the encapsulation unit 220 includes a first encapsulation unit 220-1 encapsulating at least a portion of the first side surface, and a second encapsulation unit encapsulating at least a portion of the second side surface. 220-2, a third encapsulant 220-3 encapsulating at least a portion of the third side, a fourth encapsulant 220-4 encapsulating at least a portion of the fourth side, and at least a fifth side It may be composed of a fifth encapsulation unit (not shown) that encapsulates a part.

In the catheter body 110, a wiring hole for arranging the LED wiring may be formed along the longitudinal direction, and a guide hole separated from the wiring hole may be formed along the longitudinal direction.

A protective cap 221 may cover and seal the wiring hole at the distal end of the catheter body 110 . A hole 222 connected to the guide hole may be formed in the protective cap 221 . The guide wire 240 may be movable through the hole 222 and the guide hole.

According to an embodiment of the present invention, the second wavelength band may be a wavelength band including 630 nm or a wavelength band including 660 nm. According to an embodiment of the present invention, the third wavelength band may be a wavelength band including 850 nm.

8 to 10 are views for explaining a method of manufacturing a multi-wavelength LED catheter according to an embodiment of the present invention.

Conventionally, as a method of transferring micro LEDs to a substrate, a technique of picking up and transferring one by one using static electricity or a laser or a technique of transferring several LEDs using a roll is used. However, the roll transfer technique is a method for increasing the yield in a large area, and it is difficult to apply it to a narrow area as in the present invention. There is a problem that the efficiency is lowered. The method for manufacturing a multi-wavelength LED catheter according to an embodiment of the present invention is characterized in that the micro LED is transferred by using buoyancy to solve the above problems.

Referring to FIG. 8 , in the method of manufacturing a multi-wavelength LED catheter according to an embodiment of the present invention, first, the growth substrate 10 on which the micro LED 150 is mounted may be prepared. The growth substrate 10 may have a seating portion 11 on which the micro LED 150 is individually mounted, and the micro LED 150 may be formed on the seating portion 11 with fine nano-protrusions 12 supporting the micro LED 150 . can At this time, the fine nano-protrusions 12 may be formed in the form of a filament, and may include a hydrophobic component or may be formed by coating with a hydrophobic component. For example, the hydrophobic component may be a fluororesin, a silicone resin, or the like. The growth substrate 10 having the above structure may be disposed in the accommodating unit 1 for accommodating the fluid.

Meanwhile, the growth substrate 10 may be made of a flexible material, and although not shown, may further include a handle at the end. Through this, the method of manufacturing a multi-wavelength LED catheter according to an embodiment of the present invention can apply various pressures while fixing the growth substrate 10, so that it is possible to facilitate the peeling of the micro LED.

Referring to FIG. 9 , the growth substrate 10 is disposed in the accommodation unit 1 , and a fluid such as water may be accommodated in the accommodation unit 1 . The accommodation unit 1 may include a configuration for controlling the temperature, thereby maintaining the temperature of the fluid constant.

On the other hand, the manufacturing method can prepare the catheter body 110 in the form of a polygonal column. As described above, the catheter body 110 may have a polygonal cross-section perpendicular to the longitudinal direction, and each side may be formed of a flat surface. In order to transfer the micro LED to each of the above-described sides, an adhesive (HC) may be coated. In this case, the adhesive (HC) may be a hydrophilic adhesive. For example, the pressure-sensitive adhesive (HC) may include components such as pectin, gelatin, and carboxylmethyl cellulose.

Referring to FIG. 10 , the side of the catheter body 110 coated with an adhesive (HC) is then placed toward the growth substrate 10 and then moved downward, the side of the catheter body 110 and the micro LED 150 ) can be contacted. In this case, the fluid accommodated in the accommodation unit 1, ie, water, comes into contact with the side of the catheter body 110, so that the hydrophilic pressure-sensitive adhesive (HC) is converted into a gel form, and the micro LED 150 may be attached thereto.

At this time, the micro LED 150 connected to the filament-shaped fine nano-protrusions 12 may act as a buoyant force by a portion submerged in the fluid W. In other words, in the manufacturing method of the present invention, when the growth substrate 10 is precipitated in a fluid of a certain temperature, that is, water (W) accommodated in the receiving unit 1, the micro LED 150 by the lotus effect A pressure may be applied toward the side of the catheter body 110 . By this pressure, the micro LED 150 may be more easily attached to and transferred to the hydrophilic adhesive (HC) of the catheter body 110 converted into a gel form.

On the other hand, in the method of manufacturing a multi-wavelength LED catheter according to an embodiment of the present invention, in order to more easily separate the micro LED 150 from the growth substrate 10, using carbon dioxide gas (CO ₂ injection kinife) or ultrasound (eg, cavitational ultrasonic aspiration) may be used.

Through the above-described process, the method for manufacturing a multi-wavelength LED catheter according to an embodiment of the present invention can easily and effectively transfer the micro LED to the catheter body having a narrow area.

Although the present invention has been described with reference to one embodiment shown in the drawings, it will be understood that this is merely exemplary and that those skilled in the art can make various modifications and variations therefrom. Therefore, the true technical protection scope of the present invention should be determined by the technical spirit of the appended claims.

100, 200: multi-wavelength LED catheter
110, 210: catheter body
111: wiring hole
112: guide hole
120, 120-1, 120-2, 120-3, 220, 220-1, 220-2, 220-3, 220-4: encapsulation part
121, 221: protective cap
122, 222: hole
130, 230: control device
140, 240: guide wire
150, 150-1, 150-2, 150-3: Micro LED
151: wiring

Claims (11)

Having a polygonal cross-section, the catheter body in the form of a polygonal column;
Micro LEDs respectively attached to each side of the catheter body;
A multi-wavelength LED catheter for photodynamic and photothermal therapy, including; encapsulation portions respectively attached to each side of the catheter body to cover and encapsulate the micro LED. According to claim 1,
A first micro LED emitting light of one wavelength band is attached to one side of the catheter body,
A second micro LED emitting light of a different wavelength band is attached to the other side of the catheter body,
Multi-wavelength LED catheters for photodynamic and photothermal therapy. According to claim 1,
A first micro LED emitting light of a first wavelength band and a second micro LED emitting light of a second wavelength band are alternately attached to the first side of the catheter body,
Multi-wavelength LED catheters for photodynamic and photothermal therapy. 4. The method of claim 3,
On the second side of the catheter body, a second micro LED emitting light of the second wavelength band and a third micro LED emitting light of a third wavelength band are alternately attached,
Multi-wavelength LED catheters for photodynamic and photothermal therapy. 5. The method of claim 4,
The first wavelength band is a predetermined wavelength band between 500 and 600 nm,
The second wavelength band is a predetermined wavelength band between 600 and 700 nm,
The third wavelength band is a predetermined wavelength band between 800 and 900 nm,
Multi-wavelength LED catheters for photodynamic and photothermal therapy. 5. The method of claim 4,
Controlling the temperature of the photothermal treatment based on the ratio of the number of the second microLED emitting light of the second wavelength band and the number of the third micro LED emitting light of the third wavelength band,
Multi-wavelength LED catheters for photodynamic and photothermal therapy.
5. The method of claim 4,
Controlling the temperature of photothermal treatment based on the irradiation time of the second microLED emitting the light of the second wavelength band and the irradiation time of the number of the third micro LED emitting the light of the third wavelength band,
Multi-wavelength LED catheters for photodynamic and photothermal therapy. According to claim 1,
In the catheter body, a guide hole for passing a guide wire and a wiring hole for placing an LED wire are formed,
Multi-wavelength LED catheters for photodynamic and photothermal therapy. 9. The method of claim 8,
A protective cap is disposed at the distal end of the catheter body,
A hole connected to the guide hole is formed in the protective cap,
The protective cap sealing and covering the wiring hole,
Multi-wavelength LED catheters for photodynamic and photothermal therapy. 10. The method of claim 9,
The micro LED is further attached to the tip of the catheter body,
The protective cap covers the micro LED attached to the front end of the catheter body,
Multi-wavelength LED catheters for photodynamic and photothermal therapy.
The method of claim 1,
Each side of the catheter body is coated with a hydrophilic adhesive for transferring the micro LED,
Multi-wavelength LED catheters for photodynamic and photothermal therapy.

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