KR20220128140A - Manufacturing method for therapeutic agent of athlete's foot - Google Patents

Abstract

The present invention relates to a method for manufacturing a medicine for athlete's foot fungus, containing pine bark, fig bark, and wormwood powder. The medicine for athlete's foot fungus of the present invention is manufactured by the following steps of: collecting pine bark, fig bark, and wormwood, washing the same in clean water, shaking off the water, and drying the same naturally for 5 to 10 days; pulverizing the dried pine bark, fig bark, and wormwood to a size of 1 cm or less to prepare a pulverized material; mixing the pulverized pine bark, pulverized fig bark, and pulverized wormwood in an agitator at a ratio of 1: 1: 1; putting the pulverized material after agitation into a molding machine and compression molding the same to a certain thickness; cutting the compression molded material into a circular shape or polygonal shape with a size of 3 to 10 cm, and then individually packing the same. The medicine for athlete's foot fungus can protect a skin and effectively remove an athlete's foot fungus.

Description

A method of manufacturing a treatment for athlete's foot bacteria {Manufacturing method for therapeutic agent of athlete's foot}

The present invention relates to a method for preparing a therapeutic agent for athlete's foot fungus comprising pine bark, fig bark, and wormwood powder.

In general, it can be said that the number and types of athlete's foot medicines in Korea and other countries around the world are very large enough to be second to those of diet foods or medicines.

Athlete's foot is commonly used as an external solution, ointment powder, spray, and even folk remedies to treat athlete's foot.

Most of the treatments for athlete's foot on the market are prescription products such as antifungal agents and silacyl acid.

However, mycoses of the skin, represented by athlete's foot, mainly occur in moist affected areas. Therefore, when an ointment or gel is administered to the affected area, the affected area becomes more moist, giving a feeling of discomfort or soiling of clothing. These are drawbacks in the use of gels or ointments.

In addition, since it is applied once or twice a day to the affected area of athlete's foot, it is cumbersome and does not improve, and in severe cases, it is very itchy as it flows and keratinizes. can

And the mycoses represented by athlete's foot bacillus can be said to be in a state of temporary treatment using ointments or gels. In addition, there are many problems that regular drugs for long-term treatment do not heal well despite the investment site and long time required, so those who have been treated with the methods and methods listed above are more disappointed.

With such a prescription, it is almost impossible to cure athlete's foot, and the problem is that it recurs after a certain period of time after treatment.

It can be said that the reality of athlete's foot patients is that they have no choice but to use the old method even though they know that athlete's foot is not cured. . Even to the extent that athlete's foot is said to have no 'complete eradication', it is not an exaggeration to say that it is one of the most difficult diseases to cure.

As a prior art, an athlete's foot treatment using herbal ingredients such as licorice or wood vinegar is disclosed, and a technology related to an antibacterial composition containing herbal ingredients is also disclosed.

However, there is still insufficient treatment for athlete's foot using ingredients that simply contain any one herbal ingredient and contain a significant amount of antioxidants.

Unexamined Patent Publication No. 10-2015-0059872 (2015.06.03. Athlete's foot treatment composition using herbal herbal preparations as main raw materials and manufacturing method thereof) Patent Publication No. 10-2018-0083019 (2018.07.20. Antioxidant or antibacterial composition containing fermented wormwood) Patent Publication No. 10-2020-0068967 (2020.06.16. Antibacterial and anti-inflammatory composition comprising cheongho extract, ginkgo leaf extract and fig extract as active ingredients)

The present invention was devised to solve the above problems, and it was confirmed that the athlete's foot fungus was eradicated within a short time when pine bark, fig bark, and mugwort were used as natural substances excellent for antibacterial and antioxidant activity. An object of the present invention is to provide a method for manufacturing a therapeutic agent for athlete's foot that can improve and treat athlete's foot by using it as a component.

The method for producing a treatment for athlete's foot fungus of the present invention for solving the above problems comprises the steps of: collecting pine bark, fig bark, and wormwood, washing them in clean water, shaking them off, and drying them naturally for 5 to 10 days; preparing a pulverized product by pulverizing dried pine bark, fig bark, and wormwood into sizes of 1 cm or less, respectively; The pulverized pine bark pulverized product, the fig bark pulverized product, and the pulverized wormwood pulverized product are mixed in a stirrer at a ratio of 1:1:1; Compression molding to a predetermined thickness by putting the agitated pulverized product into a molding machine; It is manufactured through the step of cutting the compression-molded molding into a circle or polygon of 3 to 10 cm in size and packaging each individually.

In addition, as another manufacturing method, a step of collecting pine bark, fig bark, and wormwood, washing in clean water, shaking off, and drying naturally for 5 to 10 days; preparing a pulverized product by pulverizing dried pine bark, fig bark, and wormwood into sizes of 1 cm or less, respectively; The pulverized pine bark pulverized product, the fig bark pulverized product, and the pulverized wormwood pulverized product are mixed in a stirrer at a ratio of 1:1:1; Putting 1 kg of the mixed pulverized product and 15 to 25 liters of water into an aging container and then aging at 40 to 45° C. for 60 to 80 hours; It is manufactured through a step of packing the matured pulverized product and water in a container with a fixed capacity.

In addition, as another manufacturing method, the steps of collecting pine bark, fig bark, and wormwood, washing in clean water, shaking off, and natural drying for 5 to 10 days; preparing a pulverized product by pulverizing dried pine bark, fig bark, and wormwood into sizes of 1 cm or less, respectively; The pulverized pine bark pulverized product, the fig bark pulverized product, and the pulverized wormwood pulverized product are mixed in a stirrer at a ratio of 1:1:1; Putting 1 kg of the mixed pulverized product and 1.8 to 2 liters of water into a fermentation vessel, followed by fermentation at 65 to 75° C. for 10 to 12 days; It is manufactured through a step of filtering the pulverized product after the fermentation process, obtaining only the extract, and packing it in an extract container.

The athlete's foot antibacterial agent prepared by the above manufacturing method is not only manufactured with ingredients that are harmless to the human body, but also greatly enhances antibacterial and antioxidant activity due to the ingredients of pine bark, fig bark, and mugwort, so that it not only protects the skin but also protects the skin and spreads to the entire foot. It has the effect of effectively eradicating or removing athlete's foot bacteria.

1 is a process diagram showing a method for preparing a therapeutic agent for athlete's foot according to a first embodiment of the present invention.

Hereinafter, with reference to the accompanying drawings, the method for manufacturing an athlete's foot treatment agent according to the present invention will be described in detail.

- Pine bark: Pine trees emit special chemical substances in order to survive in the natural environment, and the phytonside emitted by pine trees is a plant sterilizing substance, which performs antibacterial action against microorganisms and bacteria and discharges antibacterial substances. 'Pyton' means 'plant' and 'side' means 'kill'. Pine trees have been used as medicinal and health food materials for a long time. has been shown to be effective.

In particular, high-quality natural polyphenols extracted from pine bark not only have strong anti-inflammatory and antibacterial activity, but also various physiological activities such as antioxidant, anti-viral, immune enhancement, asthma improvement, blood circulation promotion, arteriosclerosis improvement, blood clot prevention, and athletic performance improvement. is known to have

In particular, according to a study on Pycnogenol, a French sea pine bark extract, the pine bark extract had an anti-inflammatory effect (M. Stenfanescu et al., Phytotherapy Research 15: 698-704; 2001), a collagen degradation inhibitory effect (Grimm et al). ., Free Rad Biol Med 36: 811-822, 2004), blemish removal effect (Ni et al., Phytother Res 16: 567-571, 2002), skin elasticity enhancing effect (D. Segger and F. Schonlau, J. Dermatol. Treatment, 15: 1-5, 2004), edema improvement (Arcangeli, Fitoterapia 71: 236-244, 2000), menstrual pain relief (Kohama & Suzuki, Eur Bull Drug Res, 7: 30-32, 1999), vascular Expanding effect (D.F. Fitzpatrick et al., J. Cardiovasc. Pharm. 32: 509-515, 1998), hypoglycemic effect (Liu et al., Diabetes Care 27(3): 839, 2004), blood pressure lowering effect (Hosseini) et al., Nutrition Res 21: 1251-1260, 2001), etc., have proven that it is a substance with strong physiologically active effects through various animal and clinical tests. is revealed by

- Fig Bark: 'Ficus (Ficuscarica L)' is a subtropical semi-arborescent deciduous broad-leaved plant belonging to the Morus family, with more than 600 varieties distributed worldwide, and is known as the first fruit used by humans in its long history. Figs, the fruit of the fig tree, have been shown to have coercive action, anticancer action, digestion action, mild diarrhea action, etc. in pharmacological experiments, and are known to be good for blood pressure enhancement, health, nourishment, constipation, hepatitis, cancer, and recovery of vitality from gynecological diseases.

In particular, the bark of the fig tree contains a lot of antioxidants, so its detoxifying action is excellent for skin beauty such as soothing the skin and recovering from wounds.

- Mugwort: It is an annual plant belonging to the genus Asteraceae and mugwort of the dicotyledonous plant, Asteraceae, and other names are Hwanghwaho (黃花蒿), Chihuho (臭蒿), Hyangsacho (香絲草), Manyoho (horse-flowering), and Hwanghyangho (黃香蒿). ), gyeseulyeop (鷄葉), chuho (秋蒿), small leaf mugwort, gaetang wormwood, etc. It has various anticancer, antioxidant, antibacterial, and skin fungal activities, and is effective in strengthening immunity and treating various inflammations.

The main active ingredients of wormwood are flavonoids, artemisinin derivatives, and terpenoids, and contain a large amount of essential oil. Until now, studies have been conducted on various pharmacological effects of artemisinin derivatives and flavonoids, which are major components of wormwood. In particular, Artesunate is a semisynthetic derivative of Artemisinin, an active ingredient in Artemisia, and has a remarkable therapeutic effect on multidrug-resistant malaria. (Artesunate for the Treatment of Severe Falciparum Malaria. N Engl J Med. 2008;358 :1829-1836)

In addition, as a result of examining the antitumor activity of artesunate, the most effective were leukemia and colorectal cancer, and the concentration exhibiting antitumor activity was the same as that of general anticancer drugs. In addition, it has shown antitumor activity against cancer cells resistant to general anticancer drugs and is being studied as a promising candidate for cancer treatment because of its low toxicity.

The flanoid component of wormwood is also known to have antimalarial effects and is being used in treatment. (The anti-malarial artesunate is also active against cancer. Int J Oncol. 2001;18(4):767-73)

A method for preparing a therapeutic agent for athlete's foot fungus prepared by using the above components as a main component will be described.

In the method of manufacturing the athlete's foot fungus therapeutic agent of the first embodiment,

a) Collect pine bark, fig bark, and mugwort, wash in clean water, shake off water, and dry naturally for 5-10 days.

b) Pulverize the dried pine bark, fig bark, and mugwort into pieces of 1 cm or less, respectively, to prepare a pulverized product. It does not matter even if it is powdered, but if the particles are too small, the compression molding process may cause problems such as scattering of the particles, so it is preferable to pulverize to about 0.5 to 1 cm.

c) Pulverized pine bark, pulverized fig bark, and pulverized mugwort are mixed in a stirrer at a ratio of 1:1:1 and then mixed evenly.

d) The pulverized product stirred and uniformly mixed with the stirrer is put into the molding machine, and the molding is completed to a certain thickness through compression molding.

e) Cut the compression molded product to a size of 3 to 10 cm using a cutting device. The shape to be cut can be cut into polygons such as circles or squares, and after cutting, each is individually packaged to complete the treatment for athlete's foot fungus.

The completed treatment for athlete's foot fungus is used by putting it in the foot bath water during the foot bath. Therefore, in order to exert its efficacy, it must be immersed in water for at least 12 hours to release the compressed state as well as to be concerned with water.

The foot bath water should be bathed at a temperature of 45°C or lower, and although there is no set time for the foot bath, it can be done for 10 to 30 minutes in the same way as the general foot bath time.

The method for producing the athlete's foot treatment agent of Example 2 is the same as in Steps a to c of Example 1, and then, 1 kg of the mixed pulverized product and 15 to 25 liters of water are put into the aging container, and then the aging container is 40 to 45 It is aged at ℃ for 60~80 hours.

After aging is completed, it is packed in a container with the capacity of the aged product including the pulverized product.

It is preferable that the aged product stored in the container is packaged after filtering the pulverized product with a sieve to obtain only the aged liquid. Even if only the aged liquid is plentiful, the ingredients contained in the pulverized product can be sufficiently effective because the aged liquid is produced during the aging period.

The treatment for athlete's foot fungus of the second embodiment may be used by diluting it in the foot bath water during a foot bath.

The manufacturing method of the athlete's foot treatment agent of Example 3 is the same as in the steps a to c of the first example, and then, 1 kg of the mixed pulverized product and 1.8 to 2 liters of water are put into the fermentation vessel, and then 10 to at 65 to 75 ° C. Fermented for 12 days.

After the fermentation process, the pulverized material is filtered through a sieve, and only the extract is obtained and packaged in an extract container.

The treatment for athlete's foot fungus of the third embodiment is intended to be drunk rather than diluted in foot bath water, and the extract may be consumed as it is or diluted in water.

Pine bark, fig bark, and mugwort, which are the main ingredients used in the present invention, contain a large amount of antibacterial and antioxidant ingredients, and have excellent anti-bacterial and anti-oxidant properties, and have excellent anti-bacterial and anti-inflammatory properties by soothing the skin and restoring wounds. , in particular, it has the advantage of being completely harmless to the human body as it is composed only of pure natural substances without the addition of chemical components.

[Experimental example]

An experiment was conducted with the treatment for athlete's foot fungus prepared by the manufacturing method of Example 1, and 20 patients with athlete's foot in the general public took a foot bath for 20 minutes every evening for 10 days, and the therapeutic effect was observed.

Athlete's foot patients are patients with severe athlete's foot ( blistering, foot odor, itching), and the use of other treatments or ointments was prohibited during the experimental period.

The results are shown in Table 1 below, and the number of patients was indicated according to the degree of feeling after treatment.

As can be seen in Table 1, the therapeutic effect of the treatment for athlete's foot fungus of the present invention started to appear slightly from the 3rd day of the foot bath, and from the 7th day, a significant number of subjects responded that they improved significantly, and during the 10th day of the foot bath, almost all subjects He replied that he had improved a lot.

Also, in response to the overall treatment effect of the 10-day foot bath, all the experimenters responded that they improved, and among them, 60% of the subjects responded that they had improved very much to the level of cure.

Therefore, it can be confirmed that the therapeutic agent for athlete's foot fungus of the present invention is effective in treating athlete's foot fungus even through the experimental examples.

Claims (4)

A step of collecting pine bark, fig bark, and wormwood, washing it in clean water, shaking off the water, and drying it naturally for 5 to 10 days;
preparing a pulverized product by pulverizing dried pine bark, fig bark, and wormwood into sizes of 1 cm or less, respectively;
Mixing the pulverized pine bark pulverized product, the fig tree bark pulverized product, and the wormwood pulverized product into a stirrer at a ratio of 1:1:1;
Compression molding to a predetermined thickness by putting the agitated pulverized product into a molding machine;
After cutting the compression-molded molding into a circle or polygon with a size of 3 to 10 cm, and packaging each individually; manufactured through,
A method of manufacturing an athlete's foot antibacterial agent, characterized in that individually wrapped packaging is poured into the foot bath water 12 hours before the foot bath, brewed and used.
A step of collecting pine bark, fig bark, and wormwood, washing it in clean water, shaking it off, and drying it naturally for 5 to 10 days;
preparing a pulverized product by pulverizing dried pine bark, fig bark, and wormwood into sizes of 1 cm or less, respectively;
The pulverized pine bark pulverized product, the fig bark pulverized product, and the pulverized wormwood pulverized product are mixed in a stirrer at a ratio of 1:1:1;
Putting 1 kg of the mixed pulverized product and 15 to 25 liters of water in an aging container, and then aging at 40 to 45° C. for 60 to 80 hours;
A method of manufacturing a treatment for athlete's foot, characterized in that it is manufactured through a step of packaging the matured pulverized product and water in a container with a fixed capacity.
3. The method of claim 2,
In the step of packaging the aged product, after filtering the pulverized product, only the aged liquid is obtained and packaged.
A step of collecting pine bark, fig bark, and wormwood, washing it in clean water, shaking it off, and drying it naturally for 5 to 10 days;
preparing a pulverized product by pulverizing dried pine bark, fig bark, and wormwood into sizes of 1 cm or less, respectively;
The pulverized pine bark pulverized product, the fig bark pulverized product, and the pulverized wormwood pulverized product are mixed in a stirrer at a ratio of 1:1:1;
Putting 1 kg of the mixed pulverized product and 1.8 to 2 liters of water into a fermentation vessel, followed by fermentation at 65 to 75° C. for 10 to 12 days;
A method of manufacturing a treatment for athlete's foot, characterized in that it is manufactured through a step of filtering the pulverized product after the fermentation process, obtaining only the extract, and packaging it in an extract container.

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