KR20220101860A - Diagnosis kit manufacturing system - Google Patents

Abstract

The present invention provides a diagnosis kit manufacturing system wherein the diagnosis kit includes: a cover provided with a space for storing reagents; a main body coupled to the cover and storing reagents and samples which are discharged from an upper cover; a piston unit mounted on the central portion of the main body and flowing the reagents or the samples stored in the main body; a valve unit mounted on the lower portion of the main body to be able to rotate and controlling the flow direction of the reagents or the samples; and a reading plate detachably provided on the main body and receiving a reaction solution reacted in the main body. The diagnosis kit manufacturing system comprises: a reagent supply unit supplying reagents to a plurality of spaces formed in the cover; a first reactant supply unit supplying, to the main body, a first reactant reacting with a reagent supplied to the cover by the reagent supply unit or a sample supplied to the main body; a second reactant supply unit supplying, to the reading plate, a second reactant for reacting with an extraction solution discharged from the main body; an assembling unit assembling the cover passing the reagent supply unit, the main body passing the first reactant supply unit, the piston unit, and the valve unit to one another; and an insertion unit inserting the reading plate, which is provided with the second reactant, into the main body passing the assembly unit. The present invention can reduce a defect ratio of the diagnosis kit.

Description

Diagnostic kit manufacturing system {DIAGNOSIS KIT MANUFACTURING SYSTEM}

The present invention relates to a diagnostic kit manufacturing system configured to mass-produce a diagnostic kit for detecting a disease or virus.

In general, a diagnostic kit may be a device that detects or measures a specific indicator material from a biological sample such as blood, urine, saliva, etc. It is used in hospitals, laboratories, and fields.

The biodiagnostic assay is widely used in various fields such as development of customized new drugs, forensic medicine, and environmental hormone detection, as well as for diagnostic purposes such as etiology confirmation, treatment, prevention, and prediction.

In recent years, diagnostic kits have been developed and used so that biodiagnostic assays can be easily performed in the field and, in particular, can detect various diseases or viruses.

However, the diagnostic kit as described above has a problem in that productivity is low because the number of parts is large and the assembly process is complicated. That is, since the process of injecting a plurality of reagents, the assembly process, the packaging process, etc. are all manually performed by the operator, there is a problem in that productivity is lowered.

When a pandemic occurs due to a worldwide epidemic such as coronavirus, a large number of virus tests must be performed quickly on site to confirm the presence of infection. There is a problem in that the supply quantity corresponding to the inspection demand cannot be met.

Accordingly, the present applicant has proposed the present invention in order to solve the above problems, and as a related prior art document, there is an 'automatic printing apparatus for a diagnostic kit' of Korean Patent Registration No. 10-1455250.

In order to solve the above problems, the present invention is configured to store and discharge various kinds of reagents, and to manufacture a diagnostic kit configured to extract nucleic acids from a biological sample through an automated process, and to rapidly mass-produce it An object of the present invention is to provide a diagnostic kit manufacturing system.

The present invention, a cover provided with a space for storing reagents; a body coupled to the cover and storing reagents and samples discharged from the upper cover; a piston part mounted on the central part of the main body and flowing a reagent or sample stored in the main body; a valve part which is rotatably mounted on the lower part of the body and controls the flow direction of the reagent or sample; and a reading plate detachably provided on the body and receiving the reaction solution reacted in the body, comprising: a reagent supply unit for supplying reagents to a plurality of spaces formed in the cover; a first reactant supply unit supplying a reagent supplied to the cover by the reagent supply unit or a first reactant reacting with a sample supplied to the main body to the main body; a second reactant supply unit for supplying a second reactant for reacting with the extraction solution discharged from the main body to the reading plate; an assembly unit for coupling the cover through the reagent supply unit, the body through the first reactant supply unit, the piston unit, and the valve unit to each other; and an insertion unit for mounting the reading plate provided with the second reactant to the main body via the assembly unit.

In addition, the reagent supply unit, a rotary table on which the cover is placed in an inverted state; a reagent injection unit arranged in plurality at a distance from each other on the periphery of the rotary table and supplying reagents having at least one kind to each of the plurality of spaces formed in the cover; and a first sealing unit sealing the space portion of the cover filled with the reagent by the reagent injection unit.

In addition, the first reactant supply unit, a first reactant injection unit for supplying a first reactant to the reaction space formed in the body; a first inspection unit for inspecting the body passing through the first reactant injection unit; and a first drying unit that dries the main body via the first inspection unit.

In addition, the second reactant supply unit may include: a washing unit for washing the reading plate; a humidifying unit for forming moisture in the reading plate passing through the washing unit; a second reactant injection unit supplying a second reactant to the reading plate in which moisture is formed by the humidifying unit; a second inspection unit that inspects the reading plate passing through the second reactant injection unit; a second inspection unit that inspects the reading plate passing through the second reactant injection unit; a second drying unit for drying the reading plate passing through the second inspection unit; and a second sealing unit sealing one surface of the read plate passing through the second drying unit with a sealing film.

In addition, the assembly unit, a bottom plate assembly unit for seating the bottom plate on the first jig; a valve member assembly unit for coupling the valve member to the bottom plate seated on the first jig by the push plate assembly unit; a body assembly unit for seating the body on an upper portion of the valve member coupled to the push plate by the valve member assembly unit; an inlet pipe assembling unit for coupling the sample inlet pipe to the body on which the valve member is seated by the body assembling unit; a first piston assembling unit for coupling a first piston to the body to which the sample inlet pipe is mounted by the inlet pipe assembling unit; a second piston assembling unit coupling a second piston to the first piston coupled to the body by the first piston assembling unit; and a cover assembly unit for coupling the cover to the main body to which the first piston and the second piston are coupled by the first piston assembly unit and the second piston assembly unit.

In addition, the insertion unit, the first transfer unit for seating the diagnostic kit assembled by the assembly unit on one side of the second jig; a second transfer unit for seating the read plate on which a second reactant is provided on the other side of the second jig by the second reactant supply unit; and a pressing unit that presses the reading plate seated on the other side of the second jig by the second transfer unit to couple it with the main body.

In addition, the second transfer unit may seat the read plate in the space of the other side of the second jig so that one end of the read plate in the longitudinal direction is exposed to the outside of the second jig.

In addition, the pressing unit may press one end in the longitudinal direction of the read plate exposed to the outside other than the second jig.

In addition, a cover supply unit for supplying a cover in an inverted state to the rotation table is disposed on one side of the rotation table, and on the other side of the rotation table, a cover receiving the cover in a sealed state from the first sealing unit is loaded. Additional can be placed.

In addition, the first drying unit may dry the first reactant injected into the reaction space of the main body and heat disinfection of the inside of the main body at the same time.

Since the diagnostic kit manufacturing system according to the present invention provides a configuration that enables mass production of POCT diagnostic kits by an automated process, diagnostic kits are provided quickly and in large quantities in situations such as a pandemic that requires rapid and frequent diagnostic tests can do.

In addition, the diagnostic kit manufacturing system according to the present invention provides a configuration in which various reagents and solutions used to detect diseases and viruses are injected into an automated process machine instead of by human hands, and a cover in which reagents and samples are stored Alternatively, by providing a configuration capable of sterilizing and inspecting the body, it is possible to significantly lower the defective rate of the diagnostic kit, and thus, to improve the detection accuracy.

1 is a plan view showing the configuration of a diagnostic kit manufacturing system according to an embodiment of the present invention.
2 is a perspective view showing the configuration of a reagent supply unit according to an embodiment of the present invention.
3 is a plan view of the reagent supply unit shown in FIG. 2 .
4 is a perspective view of a first reactant supply unit according to an embodiment of the present invention;
5A is a perspective view of a second reactant supply unit according to an embodiment of the present invention;
5B is a side view of a second reactant supply unit according to an embodiment of the present invention;
6A is a perspective view of an assembly part according to an embodiment of the present invention;
6B is a plan view of an assembly unit according to an embodiment of the present invention;
7 is a perspective view of an insert according to an embodiment of the present invention;
8 is a plan view showing the configuration of a second jig and a pressing unit according to an embodiment of the present invention.
9 is a perspective view showing the configuration of a second jig and a pressing unit according to an embodiment of the present invention.
10 is a perspective view of a diagnostic kit manufactured by a diagnostic kit manufacturing system according to an embodiment of the present invention;
11 is an exploded perspective view of the diagnostic kit shown in FIG. 10;
12 is a perspective view showing a space formed in a cover.

Advantages and features of the present invention and methods of achieving them will become apparent with reference to the embodiments described below in detail in conjunction with the accompanying drawings.

However, the present invention is not limited to the embodiments disclosed below, but will be implemented in a variety of different forms, and only these embodiments allow the disclosure of the present invention to be complete, and common knowledge in the art to which the present invention pertains It is provided to fully inform those who have the scope of the invention, and the present invention is only defined by the scope of the claims.

Hereinafter, a diagnostic kit manufacturing system according to an embodiment of the present invention will be described in detail with reference to FIGS. 1 to 12 . In describing the present invention, detailed descriptions of related well-known functions or configurations are omitted so as not to obscure the gist of the present invention.

First, before the diagnostic kit manufacturing system 100 according to an embodiment of the present invention is described, the diagnostic kit 10 manufactured by the manufacturing system 100 is briefly described with reference to FIGS. 10 and 11 . .

As shown in FIGS. 10 and 11 , the diagnostic kit 10 includes a cover 11 provided with a plurality of space portions for storing reagents, and a body for storing reagents and samples discharged from the cover 11 ( 12); a piston unit 13 mounted on the central portion of the main body 12 and flowing reagents or samples stored in the main body 12; a valve unit 14 mounted on the lower portion of the main body 12 and configured to control the flow direction of reagents or samples; and a reading plate 15 which is detachably provided on the main body 12 and receives the reaction solution reacted in the main body 12 .

The diagnostic kit 10 configured as described above is disclosed in Korean Patent Laid-Open Publication No. 10-2018-0098089 with the name of 'a biological sample analysis kit assembled with a nucleic acid extraction cartridge and various PCR panels'.

Accordingly, in the specification of the present invention, a detailed description of the configuration of the diagnostic kit 10 is omitted so as not to obscure the gist of the present invention.

A diagnostic kit manufacturing system 100 according to an embodiment of the present invention includes, as shown in FIG. 1 , a reagent supply unit 200 for supplying reagents to a plurality of spaces formed in the cover 11; The first reactant supply unit 300 for supplying a first reactant reacting with the reagent supplied to the cover 11 by the reagent supply unit 200 or the sample supplied to the main body 12 to the main body 12 . ); a second reactant supply unit 400 for supplying a second reactant for reacting with the extraction solution discharged from the main body 12 to the reading plate 15; The assembly part 500 for coupling the cover 11 via the reagent supply part 200, the body 12 via the first reactant supply part, and the piston part 13 and the valve part 14 to each other. ); and an insertion unit 600 for mounting the reading plate 15 provided with the second reactant to the main body 12 via the assembly unit 500 .

The reagent supply unit 200, as shown in FIGS. 2 and 3, a rotary table 210 on which the cover 11 is placed in an inverted state; a reagent injection unit 220 which is arranged in plurality at a distance from each other at a periphery of the rotary table 210 and supplies reagents having at least one or more types to a plurality of spaces formed in the cover 11, respectively; and a first sealing unit 230 sealing the space portion of the cover filled with reagents by the reagent injection unit 220 .

The rotary table 210 may be rotated in one direction or the other with the cover 11 placed thereon.

The reagent injection unit 220 may inject the reagent into the space of the cover 11 transferred by the rotary table 210 .

The reagent injection unit 220 may be fixedly provided on the base portion b, and a nozzle for discharging the reagent may be disposed on the rotary table 210 .

The reagent injection unit 220 may be configured such that a nozzle for discharging the reagent can be lifted up and down, and may include a pump for pulling up the reagent from the storage unit 221 in which the reagent is stored.

A plurality of space portions 11a (refer to FIG. 12 ) formed in the cover 11 may be disposed in a state of being divided from each other by a partition wall, as shown in FIG. 12 . For reference, FIG. 12 shows a state in which the cover 11 in an inverted state is transported by the holding unit.

The plurality of reagent injection units 220 may inject different types of reagents into the respective space portions 11a. For reference, in one embodiment of the present invention, it is shown in FIG. 12 that five space portions 11a are formed in the cover 11 . Accordingly, the plurality of reagent injection units 220 may inject different reagents into the five space portions 11a, respectively.

For example, the cover 11 placed on the rotary table 210 may be rotated and transported in one direction by driving the rotary table 210 . The cover 11 is stopped at the position where the reagent injection unit 220 is disposed, and then receives the reagent from the reagent injection unit 220 . When this process is performed five times, different types of reagents may be injected into the five space portions 12a formed in the cover 11 .

Meanwhile, the reagent injected into the space 11a of the cover 11 may be a material for extracting nucleic acids from the sample injected from the outside. For example, the reagent may be at least one of a lysis buffer, a binding buffer, a cleaning buffer, and an elution buffer.

The first sealing unit 230 may be disposed on one side of the rotary table 210 in the circumferential direction, and may be a component that blocks the space portion 11a of the cover 11 filled with reagents with a sealing film. . That is, the first sealing unit 230 may receive the cover 11 in which the reagent is transferred while being filled in the space 11a and block the open portion of the space 11a with a sealing film. Then, the reagent filled in the space 11a does not flow out by the sealing membrane.

On the other hand, the first sealing unit 230 is configured to cut the sealing film blocking the space portion 11a of the cover 11, and the cover 11 in which the space portion 11a is blocked by the sealing film is inverted. It may have a configuration for delivering to the rear discharge unit.

In addition, a cover supply unit 240 for supplying the cover 11 in an inverted state to the rotation table 210 may be disposed on one side of the rotation table 210 , and the first sealing portion is located on the other side of the rotation table 210 . A cover loading unit 250 receiving the cover 11 in a closed state of the space portion 11a from the unit 230 may be disposed.

The first reactant supply unit 300 includes, as shown in FIG. 4 , a first reactant injection unit 310 for supplying a first reactant to the reaction space formed in the main body 12 ; a first inspection unit 320 for inspecting the main body 12 via the first reactant injection unit 310; and a first drying unit 330 for drying the main body 12 via the first inspection unit 320 .

The first reactant injection unit 310 may be disposed on one side in the longitudinal direction of the conveyor c1 to which the body 12 is transported, and has the same configuration as the reagent injection unit 220 described in the reagent supply unit 200 . can have

The first reactant injected from the first reactant injection unit 310 into the body 12 may be preferentially filled in a reaction space in which a reagent and a sample are mixed. For reference, the reaction space formed in the main body 12 may be referred to as a space in which the reagents filled in the space 11a of the cover 11 and the sample introduced into the main body 12 from the outside are mixed with each other. Here, the first reactant may be a material that reacts with the extraction solution formed by mixing the reagent and the sample, and may be provided in the reaction space of the body 12 while having a liquid form or a solid form. For reference, in one embodiment of the present invention, it is described that the first reactant in a liquid state is filled in the reaction space of the body 12 . In addition, the sample introduced into the reaction space through the sample inlet pipe (P, see FIGS. 10 and 11) to be described later may be at least one of blood, manure, saliva, and mucus.

For example, the first reactant may be a material that helps the nucleic acid contained in the extraction solution to be easily extracted from the reading plate 15 to be described later. That is, it may be a material having a magnetic property that the nucleic acid contained in the extraction solution can cling. Then, the nucleic acid attached to the first reactant can be easily separated from the extraction solution. At this time, the main body 12 may be provided with a magnet for separating the first reactant and the nucleic acid.

The first inspection unit 320 may be a component for determining the amount of the first reactant injected into the main body 12 or the presence or absence of foreign substances formed inside the main body 12 . That is, the first inspection unit 320 is a component for determining whether the first reactant is injected into the main body 12 by a predetermined amount or for determining whether a foreign material is present in the main body 12 . .

The first inspection unit 320 may inspect the main body 12 by a vision inspection method of irradiating light to the main body 12 transported along the conveyor c1. That is, the first inspection unit 320 may be configured to include a camera provided with an illumination module emitting infrared light or visible light.

As described above, the first inspection unit 320 for inspecting a product in the vision inspection method is a well-known configuration that can be easily implemented by those skilled in the art, and thus detailed configuration descriptions thereof will be omitted in the context of the present invention.

The first drying unit 330 may be a component for drying the main body 12 transported along the conveyor c1 via the first inspection unit 320 .

The first drying unit 330 may be provided along the longitudinal direction of the conveyor c1 while being disposed on the conveyor c1.

The first drying unit 330 may heat the interior of the body 12 while drying the first reactant injected into the reaction space of the body 12 . That is, the first drying unit 330 may dry the first reactant injected into the interior and reaction space of the main body 12 by an infrared drying method. For reference, the first reactant may be dried by the first drying unit 330 to provide a gel-type form in the reaction space.

On the other hand, the main body supply unit 340 is disposed on one side in the longitudinal direction of the conveyor c1 to which the main body 12 is transferred, and the main body 12 that has completed the drying process is received and loaded on the other side in the longitudinal direction of the conveyor c1. A loading unit 350 may be disposed.

The second reactant supply unit 400 includes, as shown in FIGS. 5A and 5B , a washing unit 410 for washing the reading plate 15 ; a humidifying unit 420 for forming moisture on the surface of the reading plate 15 cleaned by the washing unit 410; a second reactant injection unit 430 for supplying a second reactant to the reading plate 15 on which moisture is formed on the surface by the humidifying unit 420; a second inspection unit 440 for inspecting the reading plate 15 via the second reactant injection unit 430; a second drying unit 450 for drying the reading plate 15 via a second inspection unit 440; and a second sealing unit 460 for sealing one surface of the reading plate 15 via the second drying unit 450 with a sealing film.

The cleaning unit 410 may be provided at one side in the longitudinal direction of the conveyor c2 to which the read plate 15 is transferred, and may wash the read plate 15 by a cleaning method using plasma. That is, the reading plate 15 may be sterilized by the washing unit 410 . Meanwhile, the cleaning unit 410 may preferentially spray compressed air before the plasma disinfection process in order to remove foreign substances adhering to the surface of the reading plate 15 .

The humidifying unit 420 may be a component that forms moisture on the surface of the read plate 15 as described above. The reason why moisture is formed on the surface of the read plate 15 is so that the second reactant can easily diffuse on the surface of the read plate 15 .

The second reactant injection unit 430 may be disposed on one side in the longitudinal direction of the conveyor c2 to which the read plate 15 is transferred, and may include the reagent injection unit 220 or the first reagent injection unit 220 described in the reagent supply unit 200 . It may have the same configuration as the first reactant injection unit 310 described in the first reactant supply unit 300 .

The second reactant supplied from the second reactant injection unit 430 to the read plate 15 may be a substance that reacts with the extraction solution discharged from the main body 12 to amplify the nucleic acid contained in the extraction solution. For reference, in one embodiment of the present invention, it is described that the second reactant in a liquid state is filled in the reading plate 15 .

The second inspection unit 440 may be a component for determining the amount of the second reactant injected into the reading plate 15 , or whether foreign matter is formed on the surface of the reading plate 15 . That is, the second inspection unit 440 is a component that determines whether a predetermined amount of the second reactant has been injected into the reading plate 15 or detects whether foreign matter is present on the surface of the reading plate 15 . can do.

The second inspection unit 440 may inspect the reading plate 15 in a vision inspection method of irradiating light to the reading plate 15 transferred along the conveyor c2 . That is, the second inspection unit 440 may be configured to include a camera provided with an illumination module emitting infrared light or visible light. As described above, the first inspection unit 440 for inspecting a product in the vision inspection method is a well-known configuration that can be easily implemented by those skilled in the relevant field, and thus a detailed configuration description thereof will be omitted in the context of the present invention.

The second drying unit 450 may be a component for rolling the reading plate 15 transferred along the conveyor c2 while passing through the second inspection unit 440 .

The second drying unit 450 may be provided along the longitudinal direction of the conveyor c1 while being disposed on the conveyor c2.

The second drying unit 450 may heat-sterilize the surface of the read plate 15 while drying the second reactant injected into the groove formed in the read plate 15 . That is, the second drying unit 450 may dry the surface of the read plate 15 and the second reactant injected into the read plate 15 in an infrared drying method. For reference, the second reactant injected into the groove of the read plate 15 may be dried by the second drying unit 450 to be transformed into a gel type, or may be transformed into a solid form.

The second sealing unit 460 may be disposed on the other side in the longitudinal direction of the conveyor c2, and may be said to be a component that blocks one surface of the reading plate 15 passing through the drying unit 450 with a sealing film. have. That is, the second sealing unit 460 may block one surface of the read plate 15 with a sealing film so that the second reactant injected on one surface of the read plate 15 does not flow out.

On the other hand, the read plate supply unit 470 is disposed on one side in the longitudinal direction of the conveyor c2 to which the read plate 15 is transferred, and the read plate 15 after the drying and sealing processes are completed on the other longitudinal side of the conveyor c2. A reading plate loading unit 480 for receiving and loading may be disposed.

The assembly unit 500, as shown in FIGS. 6a and 6b, a bottom plate assembly unit 510 for seating the bottom plate 14a of the valve part 14 on the first jig j1; a valve member assembly unit 520 for coupling the valve member 14b to the bottom plate 14a seated on the first jig j1 by the push plate assembly unit 510; a body assembly unit 530 for seating the body 12 on an upper portion of the valve member 14b coupled to the bottom plate 14a by the valve member assembly unit 520; an inlet pipe assembling unit 540 for coupling a sample inlet pipe (P, see FIG. 10) to the body 12 on which the valve member 14b is seated by the body assembling unit 530; a first piston assembling unit 550 for coupling the first piston 13a of the piston 13 to the body 12 on which the sample inlet pipe P is mounted by the inlet pipe assembling unit 540; A second piston assembling unit 560 for coupling the second piston 13b of the valve part 13 to the first piston 13a coupled to the body 12 by the first piston assembling unit 550 . ; and the cover 11 to the main body 12 to which the first piston 13a and the second piston 13b are coupled by the first piston assembly unit 550 and the second piston assembly unit 560. ) a cover assembly unit 570 for coupling; may include.

The first jig j1 forms a predetermined seating space in which the bottom plate 14a, the body 14a, and the cover 11 constituting the diagnostic kit 10 can be accommodated, and follows the conveyor c3. can be transported In addition, the seating space may be formed in plurality.

The bottom plate assembly unit 510, the valve member assembly unit 520, the body assembly unit 530, the inlet pipe assembly unit 540, the first piston assembly unit 550, and the second The piston assembly unit 560 and the cover assembly unit 570 may be disposed at predetermined intervals along the longitudinal direction of the conveyor c3 to which the first jig j1 is transferred, and constitute the diagnostic kit 10 . It has a configuration that can grip and transport each of the components. For example, it may be configured to be movable by a variety of known driving means, and may include a known gripping means capable of gripping each component constituting the diagnostic kit 10 .

In addition, the diagnostic kit 10 assembled by the assembly unit 500 may be transferred to the insertion unit 600 , which will be described later.

The insertion unit 600 is, as shown in FIGS. 1 and 7, a first transfer unit ( 610); a second transfer unit 620 for seating the read plate 15 on which a second reactant is provided by the second reactant supply unit 400 on the other side of the second jig j2; and a pressing unit 630 that presses the reading plate 15 seated on the other side of the second jig j2 by the second transfer unit 620 and couples it with the main body 12 of the diagnostic kit 10 . ); may be included.

The second jig j2 includes a space on one side in which the diagnostic kit 10 assembled in the assembly unit 500 can be seated, and a readout in which a second reactant is provided by the second reactant supply unit 400 . The other side space in which the plate 15 can be seated is formed. This second jig j2 may be transferred along the conveyor c4.

The first transfer unit 610 has a configuration capable of holding the diagnostic kit 10 assembled by the assembly unit 500 and seated in a space on one side of the second jig j2. For example, it may be movable by a variety of known driving means, and may include a known gripping means capable of gripping the diagnostic kit 10 .

The second transfer unit 620 has a configuration capable of holding the read plate 15 provided with the second reactant material by the second reactant supply unit 400 and seated in the space on the other side of the second jig j2. have. For example, it may be movable by a variety of known driving means, and may include a known gripping means capable of gripping the read plate 15 .

8 and 9, the diagnostic kit 10 is seated in the space on one side of the second jig j2 by the first transfer unit 610 and the second transfer unit 620, and the other space The reading plate 15 may be seated there.

At this time, the read plate 15 is seated in the other space of the second jig j2 so that one end thereof in the longitudinal direction is exposed to the outside in the space on the other side of the second jig j2 . That is, the second transfer unit 620 seats the read plate 15 on the other side of the second jig j2 so that one end in the longitudinal direction of the read plate 15 is exposed to the outside of the second jig j2 . can do it

The pressing unit 630 includes a first pressing member 631 that presses one end in the longitudinal direction of the reading plate 15 exposed to the outside of the second jig j2 in the direction in which the diagnostic kit 10 is seated. ) and a second pressing member 632 for pressing the upper end of the diagnostic kit 10 seated in the space on one side of the second jig j2 with a predetermined pressure.

When the first pressing member 631 presses one end of the read plate 15 in the longitudinal direction with a predetermined pressure, the other end of the read plate 15 in the longitudinal direction of the main body 12 is seated on the second jig j2. It can be inserted into the coupling hole of Then, the reading plate 15 and the main body 12 are coupled to each other.

Meanwhile, in the second pressing member 632 , when the first pressing member 631 presses one end of the read plate 15 in the longitudinal direction, the diagnostic kit 10 seated on the second jig j2 flows. make sure it doesn't happen That is, the other longitudinal end of the reading plate 15 can be easily and accurately inserted into the coupling hole of the main body 12 by preventing the diagnostic kit 10 from flowing from the external force generated through the first pressing member 631 . let it be

The first pressing member 631 and the second pressing member 632 may be linearly reciprocated by receiving power from a known driving means, and may include a buffering means (not shown) such as an elastic spring. .

The diagnostic kit 10 in a state in which the reading plate 15 and the main body 12 are combined can be shipped as a final product through a packaging unit 700 (refer to FIG. 1 ) that performs a known labeling process and a packaging process. .

That is, the diagnostic kit 10 passed through the insertion unit 600 undergoes a labeling process of attaching a label to the main body 12 or cover 11, and then undergoes a first packaging process of being inserted and packaged into a plastic molding container. can In addition, the plastic molded container in which the diagnostic kit is packaged in the first packaging process may be accommodated in a box and subjected to a first packaging process in which it is packaged. Each of these processes can be performed by a known labeling apparatus and a known molding apparatus for molding, sealing, and cutting a plastic molding container, and a box-making apparatus for forming a box. In order not to do so, the configuration description of each device is omitted.

Although specific embodiments according to the present invention have been described so far, various modifications are possible without departing from the scope of the present invention.

Therefore, the scope of the present invention should not be limited to the described embodiments, but should be defined by the claims described below as well as the claims and equivalents.

100: diagnostic kit manufacturing system
200: reagent supply 210: rotary table
220: reagent injection unit 230: first sealing unit
300: first reactant supply unit 310: first reactant injection unit
320: first inspection unit 330: first drying unit
400: second reactant supply unit 410: washing unit
420: humidification unit 430: second reactant injection unit
440: second inspection unit 450: second drying unit
460: second sealing unit 500: assembly part
510: bottom plate assembly unit 520: valve member assembly unit
530: body assembly unit 540: inlet pipe assembly unit
550: first piston assembly unit 560: second piston assembly unit
570: cover assembly unit 600: insertion unit
610: first transfer unit 620: second transfer unit
630: pressurization unit 700: packaging unit
10: diagnostic kit 11: cover
12: body 13: piston part
13a: first piston 13b: second piston
14: valve part 14a: bottom plate
14b: valve member 15: read plate

Claims (10)

a cover provided with a space for storing reagents; a body coupled to the cover and storing reagents and samples discharged from the upper cover; a piston part mounted on the central part of the main body and flowing a reagent or sample stored in the main body; a valve part which is rotatably mounted on the lower part of the body and controls the flow direction of the reagent or sample; and a reading plate detachably provided on the main body and receiving the reaction solution reacted in the main body;
a reagent supply unit for supplying reagents to a plurality of spaces formed in the cover;
a first reactant supply unit supplying a reagent supplied to the cover by the reagent supply unit or a first reactant reacting with a sample supplied to the main body to the main body;
a second reactant supply unit for supplying a second reactant for reacting with the extraction solution discharged from the main body to the reading plate;
an assembly unit for coupling the cover through the reagent supply unit, the body through the first reactant supply unit, the piston unit, and the valve unit to each other; and
and an insertion unit for mounting the reading plate provided with the second reactant to the main body via the assembly unit.
The method of claim 1,
The reagent supply unit,
a rotary table on which the cover is placed in an inverted state;
a reagent injection unit arranged in plurality at a distance from each other at a periphery of the rotary table and supplying reagents having at least one kind or more to a plurality of spaces formed in the cover; and
and a first sealing unit sealing the space of the cover filled with the reagent by the reagent injection unit.
3. The method of claim 2,
The first reactant supply unit,
a first reactant injection unit for supplying a first reactant to the reaction space formed in the body;
a first inspection unit for inspecting the body passing through the first reactant injection unit; and
and a first drying unit for drying the main body passing through the first inspection unit.
4. The method of claim 3,
The second reactant supply unit,
a washing unit for washing the reading plate;
a humidifying unit for forming moisture in the reading plate passing through the washing unit;
a second reactant injection unit supplying a second reactant to the reading plate in which moisture is formed by the humidifying unit;
a second inspection unit that inspects the reading plate passing through the second reactant injection unit;
a second inspection unit that inspects the reading plate passing through the second reactant injection unit;
a second drying unit for drying the reading plate passing through the second inspection unit; and
and a second sealing unit sealing one surface of the reading plate passing through the second drying unit with a sealing film.
5. The method of claim 4,
The assembly part,
a bottom plate assembly unit for seating the bottom plate on the first jig;
a valve member assembly unit for coupling the valve member to the bottom plate seated on the first jig by the push plate assembly unit;
a body assembly unit for seating the body on an upper portion of the valve member coupled to the push plate by the valve member assembly unit;
an inlet pipe assembling unit for coupling the sample inlet pipe to the body on which the valve member is seated by the body assembling unit;
a first piston assembling unit for coupling a first piston to the body to which the sample inlet pipe is mounted by the inlet pipe assembling unit;
a second piston assembling unit coupling a second piston to the first piston coupled to the body by the first piston assembling unit; and
and a cover assembly unit coupling the cover to the main body to which the first piston and the second piston are coupled by the first piston assembly unit and the second piston assembly unit. .
6. The method of claim 5,
The insert is
a first transfer unit for seating the diagnostic kit assembled by the assembly unit on one side of the second jig;
a second transfer unit for seating the read plate on which a second reactant is provided on the other side of the second jig by the second reactant supply unit; and
and a pressing unit which presses the reading plate seated on the other side of the second jig by the second transfer unit and combines it with the main body.
7. The method of claim 6,
The second transfer unit is configured to seat the read plate in a space on the other side of the second jig so that one end of the read plate in the longitudinal direction is exposed to the outside of the second jig.
8. The method of claim 7,
The pressurizing unit,
A diagnostic kit manufacturing system, characterized in that pressurizing one end in the longitudinal direction of the reading plate exposed to the outside other than the second jig.
3. The method of claim 2,
A cover supply unit for supplying an upside-down cover to the rotary table is disposed on one side of the rotary table,
A diagnostic kit manufacturing system, characterized in that a cover loading unit receiving a cover in a sealed state from the first sealing unit is disposed on the other side of the rotary table.
4. The method of claim 3,
The first drying unit dries the first reactant injected into the reaction space of the main body and at the same time thermally sterilizes the inside of the main body.

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