KR20220086098A - Needle guide unit of electroporation injector - Google Patents

Abstract

The disclosed content is that the electrode fixing substrate on which the electrode is fixed is installed in the front of the electroporation injector in a replaceable manner, and the needle of the syringe is connected through the rear side, so that the protrusion length of the needle with respect to the electrode can be adjusted according to the treatment site. It relates to a needle guide unit of an electroporation injector that can be easily made and that the replacement of the electrode fixing substrate on which the electrode is fixed and the replacement of the syringe including the needle can be individually easily performed.
Disclosed is a needle guide unit provided in an electroporation injector that allows a chemical solution to easily penetrate into the body through application of an electric field by an electrode at the same time as injection of a chemical solution by a needle, front and rear on the front side of the electroporation injector A housing that is movably installed and has an open front housing shape and a first needle through hole is formed in the center of the rear surface, and the needle hub that is integrally coupled to protrude from the center of the rear surface of the housing and connects the syringe and the needle is detachable An electrode having a needle hub coupling bushing coupled to the housing, and the electrode inserted into the housing and protruding forward to allow current to be applied, and a second needle through hole through which the needle passing through the first needle through hole is formed in the center. The needle guide unit of the electroporation injector comprising a fixed substrate is presented as an embodiment.

Description

Electroporation injector needle guide unit

The disclosed subject matter relates to a needle guide unit of an electroporation injector that allows a chemical solution to easily penetrate into a cell by increasing the permeability of the plasma membrane by applying an electric current to the cell at the same time as the injection of the chemical solution.

Unless otherwise indicated herein, the contents described in this identification are not prior art to the claims of this application, and the description in this identification is not admitted to be prior art.

As the skin is evaluated as one of competitiveness, as the era of skin care not only for women but also for men is coming, the number of people receiving skin treatment or skin care at dermatologists or esthetic shops is increasing. The so-called self-home care group who takes care of the skin is also increasing. In line with this, in the home beauty device market, beauty devices equipped with various functions are being launched.

One of the most popular techniques among various skin treatments or skin care methods is electroporation, also called electroporation. Originally, the skin had a function of protecting the human body from external stimuli or substances, and thus showed an impermeable property to water-soluble ingredients. However, electroporation is a method in which electric pulses applied to skin cells and tissues temporarily create penetration holes to allow active ingredients to penetrate, maximizing the absorption rate of nutrients in drugs or cosmetics that could not be absorbed deep into the dermis. In particular, since the electroporation technology exhibits an absorption rate close to 10 times that of the existing iontophoresis method, the best effect can be expected depending on the medium.

As an example of an electroporation injector that increases the permeability of the plasma membrane by increasing the permeability of the plasma membrane by applying an electric current to the cells at the same time as the injection of the drug solution, Korean Patent Laid-Open No. 10-2018-0098591 (2018.09.04. .disclosure) includes a housing with a volume defined therein; a circuit board disposed at least partially within the volume; an electrode extending from the housing and in electrical communication with the circuit board; and a battery pack, wherein the battery pack is coupled to a battery pack housing, a plurality of battery cells disposed within the battery pack housing, a first power lead in electrical communication with the circuit board, and the plurality of battery cells; A handset of an electroporation device is disclosed, comprising: a second power lead in electrical communication with the circuit board; and a safety switch disposed within the battery pack housing and coupled between the first power lead and the plurality of battery cells.

This electroporation injector simultaneously includes an electrode for applying an electric field (electrical pulse) to the cells and a needle for injecting a chemical solution. In particular, Korean Patent Publication No. 10-2015-0071181 (published on June 26, 2015) has a front A cylindrical casing in which a through hole is formed; a hub coupled to the rear end of the casing so as to be movable back and forth and having a hub shaft protruded to the rear to which an injector for injecting the target material is to be coupled; a needle coupled to the hub, protruding forward through a through hole of the casing, and inserted into a living tissue to inject the target material into the outer cell membrane; It is coupled to the hub, protrudes forward through the through hole of the casing, extends side by side adjacent to the needle, and is inserted into the living tissue at the same time as the needle, and artificial perforation for penetration of the target material into the outer cell membrane by applying a high voltage pulse an electrode needle to form a; and a spring interposed in the casing to elastically bias the hub to the rear, wherein the hub has an accommodation space formed at the front, the hub shaft protrudes at the rear, and the rear end of the spring is seated in the center A hub body on which a flange is formed to protrude, a needle fixing plate coupled to the rear end side of the receiving space and to which a plurality of needles are coupled, and a front side of the receiving space coupled to a plurality of electrode needles, through which the needles are penetrated An electrode needle integrated type for electroporation, characterized in that it comprises an electrode fixing plate having a needle through hole formed therein and an electrode connection part protruding from one side of the casing so that a high voltage pulse is applied to the electrode needle from an external high voltage pulse generator on one side. A needle device is disclosed.

However, in the case of the electrode needle integrated needle device of the electroporation injector described above, the electrode for applying a current (electrical pulse) to the cells and the needle for injecting the chemical solution are integrated into one configuration, so the needle for the electrode depends on the treatment site. There was a problem in that it was not easy to control the protrusion length of the device and it was not easy to replace the parts.

1. Korean Patent Publication No. 10-2018-0098591 (published on September 4, 2018) 2. Korean Patent Publication No. 10-2015-0071181 (published on June 26, 2015)

As the electrode fixing substrate on which the electrode is fixed is replaceably mounted on the front side and the needle of the syringe is connected through the rear side, the protrusion length of the needle with respect to the electrode can be easily adjusted depending on the treatment site, and the electrode is fixed. An object of the present invention is to provide a needle guide unit for an electroporation injector that facilitates replacement of a fixed electrode substrate and replacement of a syringe including a needle.

In addition, it is not limited to the technical problems as described above, and it is obvious that another technical problem may be derived from the following description.

Disclosed is a needle guide unit provided in an electroporation injector that allows a chemical solution to easily penetrate into the body through application of an electric field by an electrode at the same time as injection of a chemical solution by a needle, front and rear on the front side of the electroporation injector A housing that is movably installed and has an open front housing shape and a first needle through hole is formed in the center of the rear surface, and the needle hub that is integrally coupled to protrude from the center of the rear surface of the housing and connects the syringe and the needle is detachable An electrode having a needle hub coupling bushing coupled to the housing, and the electrode inserted into the housing and protruding forward to allow current to be applied, and a second needle through hole through which the needle passing through the first needle through hole is formed in the center. The needle guide unit of the electroporation injector comprising a fixed substrate is presented as an embodiment.

The needle guide unit of the electroporation injector according to an embodiment of the present disclosure is an elastic coil that is through-coupled to an electrode to elastically deflect the housing to which the electrode fixing substrate is inserted in the rear with respect to the front end side of the electroporation injector. It further includes a spring.

According to the needle guide unit of the electroporation injector according to an embodiment of the present disclosure, not only the electrode fixing substrate having the electrode fixed thereon is installed interchangeably on the front side, but also the needle hub connecting the syringe and the needle is inserted and coupled to the rear side. As the needle is configured to protrude forward, not only can the length of the protrusion of the needle to the electrode be easily adjusted depending on the treatment site, but also the replacement and installation of the electrode fixing substrate on which the electrode is fixed and the replacement and combination of the syringe including the needle are individually performed. It has the advantage of being easily accomplished.

Effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the description of the claims.

1 is a perspective view of an electroporation injector including a needle guide unit according to an embodiment of the disclosed subject matter.
2 is a partially exploded perspective view of an electroporation injector including a needle guide unit according to an embodiment of the present disclosure;
3 is an exploded perspective view of a needle guide unit of an electroporation injector according to an embodiment of the present disclosure;
Figure 4 is a cross-sectional structural view of the needle guide unit of the electroporation injector according to an embodiment of the disclosed subject matter.

Hereinafter, the configuration, operation, and effect of the preferred embodiment will be described with reference to the accompanying drawings. For reference, in the following drawings, each component is omitted or schematically illustrated for convenience and clarity, and the size of each component does not reflect the actual size. In addition, the same reference numerals refer to the same components throughout the specification, and reference numerals for the same components in individual drawings will be omitted.

Hereinafter, the configuration, operation, and effect of the preferred embodiment will be described with reference to the accompanying drawings. For reference, in the following drawings, each component is omitted or schematically illustrated for convenience and clarity, and the size of each component does not reflect the actual size. In addition, the same reference numerals refer to the same components throughout the specification, and reference numerals for the same components in individual drawings will be omitted.

1 is a perspective view of an electroporation injector including a needle guide unit according to an embodiment of the disclosed subject matter.

The electroporation injector 100 including the needle guide unit 1 according to an embodiment of the disclosure is to allow the chemical solution to easily penetrate into the body through the injection of the chemical solution by the needle and the application of the electric field by the electrode at the same time. , has a gun-shaped body 110 that can be gripped by a user or operator as a whole, as shown in FIG. 1 . A control button 111 for setting such as manual forward or manual reverse of the syringe mounted therein is provided on the rear upper side of the body 110, and is linked to the control button 111 inside the rear upper side of the body 110 A separate control panel can be arranged.

In addition, a gripping handle 120 is provided on the lower side of the body 110, a control board can be arranged in the gripping handle 120, and a trigger unit 121 for turning ON or OFF the operation in front of the gripping handle 120 ) is provided. In addition, the cartridge 130 is detachably coupled to the upper portion of the body 110, and the needle electrode for medicament injection and the electrode for current application are guided simultaneously in and out of the front of the cartridge 130. A needle electrode withdrawing guide unit 140 ) is provided.

2 is a partially exploded perspective view of an electroporation injector including a needle guide unit according to an embodiment of the present disclosure;

In the cartridge 130 of the electroporation injector 100 including the needle guide unit 1 according to an embodiment of the present disclosure, a syringe including a needle and filled with a chemical solution is installed in a replaceable manner.

In addition, as shown in FIG. 2 , a syringe holder 150 on which a syringe is seated and supported is slidably provided on the lower side of the cartridge 130 , for example, by magnetic force, and the body 110 has a syringe holder 150 . ) is provided with, for example, a syringe transfer mechanism 160 in the form of a lead screw for reciprocating back and forth. In addition, the plunger support rod 170 for pushing the plunger of the syringe forward is also provided to be movable back and forth by the pressure belt transfer mechanism (not shown).

In addition, an electrode 33 for applying a current is provided on the front side of the cartridge 130 and a needle guide unit 1 of an electroporation injector according to an embodiment of the disclosure for guiding the penetration of a needle (not shown). do. In addition, a forward and backward movement guide 180 forming a guide rail guiding the forward and backward movement of the needle guide unit 1 of the electroporation injector according to an embodiment of the disclosed contents is provided on the lower front side of the cartridge 130 and moves forward and backward A power connection plug (not shown) for applying electricity to the electrode 33 is provided on the rear lower surface of the guide 180 .

3 is an exploded perspective view of a needle guide unit of an electroporation injector according to an embodiment of the disclosed subject matter, and FIG. 4 is a cross-sectional structural view of a needle guide unit of an electroporation injector according to an embodiment of the disclosed subject matter.

The needle guide unit 1 of the electroporation injector according to an embodiment of the disclosure is installed movably back and forth on the front side of the electroporation injector 100 (refer to FIG. 2 ) and has an open front housing shape and has a rear surface A housing 10 having a first needle through hole 11 formed in the center thereof, and a needle hub 5 that is integrally coupled to protrude from the center of the rear surface of the housing 10 and connects the syringe 3 and the needle 7 A needle hub coupling bushing 20 to which is detachably coupled, and an electrode 33 inserted and coupled into the housing 10 and protruding forward are provided to allow current to be applied, and the first needle through hole 11 is penetrated in the center. It includes an electrode fixing substrate 30 in which a second needle through hole 31 through which one needle 7 is penetrated is formed.

Here, the housing 10 forms the body frame of the needle guide unit 1 of the electroporation injector according to an embodiment of the present disclosure, and the front side of the electroporation injector 100 (refer to FIG. 2 ), in particular It is installed in the forward and backward movement guide (180: see FIG. 2) to be movable forward and backward.

The housing 10 has an overall front open housing, in particular, a rectangular housing shape, and a first needle through hole 11 for penetrating the needle 7 is formed in the center of the rear surface.

In addition, conducting wire guide slits 13 are formed on both sidewalls of the housing. The lead wire guide slit 13 is a power connection plug (not shown) provided on the lower surface of the lead wire 35 for applying a current to the electrode fixing substrate 30, which will be described later, is drawn out, and the forward and backward movement guide 180 (refer to FIG. 2). ), and is formed in a straight line at the front ends of both side walls of the housing up to a certain length.

This housing 10 can be manufactured from a synthetic resin material.

In the center of the rear surface of the above-described housing 10, the needle hub coupling bushing 20 is integrally coupled to protrude. The needle hub coupling bushing 20 is a component in which the needle hub 5 connecting the syringe 3 and the needle 7 is detachably inserted and coupled, and the needle hub 5 is press-fitted inside the needle hub ( A hollow part corresponding to the outline of 5) is formed.

The needle hub coupling bushing 20 may be made of a synthetic resin material, but is preferably made of a metal material having relatively high strength for durability.

The needle hub coupling bushing 20 may be press-fitted to the coupling protrusion protruding from the rear surface of the housing 10, or may be integrated into the housing through insert injection when the housing 10 is manufactured, depending on the embodiment. .

The above-described housing 10 is inserted and coupled to the electrode fixing substrate 30 . The electrode fixing substrate 30 is a component that allows power (current) to be applied to the electrode 33 for applying a current for electroporation in the body, and a (+) or (-) current is provided to a specific contact point. For example, it is formed of a printed circuit board having a shape such as a square.

In the center, the second needle through-hole 31 through which the needle 7 through the first needle through-hole 11 passes is formed in communication with the first needle through-hole 11, and at a specific contact point exposed to the front, the front The rear ends of the plurality of electrodes 33 protruding to the poles are fixed so as to be able to apply power by, for example, soldering. It is preferable that one electrode 33 is provided at each of four points on the front surface of the electrode fixing substrate 30 .

In particular, the electrode 33 is fixed to the vertex of a square having a side of 10 mm, and it is preferable to protrude to the outside by a length of about 25 mm through the needle electrode withdrawing guide unit 140 (refer to FIGS. 1 and 2). In addition, the electrode 33 is preferably insulated except for about 3 mm of the end. In addition, it is preferable that the electrode 33 protrudes to the outside with a length of 25 mm through the needle electrode withdrawing guide unit 140 (refer to FIGS. 1 and 2). The protrusion length of the needle 7 with respect to the electrode 33 is adjustable through the operation of the button 111 (refer to FIGS. 1 and 2).

In addition, it is preferable that the electrode fixing substrate 30 is detachably coupled to the housing 10 by a fastening screw 37 . In this case, since the electrode fixing substrate 30 can be easily replaced and mounted, maintenance or replacement of the electrode fixing substrate 30 including the electrode 33 can be easily performed.

In addition, the end of the conductive wire 35 can be bonded to the rear contact point of the electrode fixing substrate 30, and the conductive wire 35 can be drawn out through the conductive wire guide slits 13 formed on both sidewalls of the housing 10.

An elastic coil spring 40 may be through-coupled to the aforementioned electrode 33 . The elastic coil spring 40 has a rear end supported on the electrode fixing substrate 30 and a front end supported on the needle electrode withdrawing guide unit 140; It serves to elastically deflect the end side, in particular, backward with respect to the needle electrode withdrawing guide unit 140 (refer to FIG. 2).

In the needle guide unit 1 of the electroporation injector according to an embodiment of the disclosed subject matter as described above, the electrode fixing substrate 30 on which the electrode 33 is fixed to the front side of the housing 10 is a fastening screw 37 ), the needle hub 5 connecting the syringe 3 and the needle 7 is inserted and coupled to the needle hub coupling bushing 20 provided at the rear of the housing 10, and the needle 7 ) protrudes forward through the first needle through hole 11 of the housing 10 and the second needle through hole 31 of the electrode fixing substrate 30 .

Due to this, the protrusion length of the needle 7 with respect to the electrode 33 can be easily adjusted according to the treatment site, and the electrode fixing substrate 30 on which the electrode 33 is fixed can be easily replaced with respect to the housing 10. It is possible, and replacement of the syringe 3 including the needle 7 can also be made easily.

Although preferred embodiments of the present invention have been described with reference to the accompanying drawings, the embodiments described in the present specification and the configurations shown in the drawings are only the most preferred embodiments of the present invention and represent all of the technical spirit of the present invention. Therefore, it should be understood that there may be various equivalents and modifications that can be substituted for them at the time of filing the present application. Therefore, the embodiments described above are to be understood as illustrative and not restrictive in all respects, and the scope of the present invention is indicated by the following claims rather than the detailed description, and the meaning and scope of the claims and their All changes or modifications derived from the concept of equivalents should be construed as being included in the scope of the present invention.

1: Needle guide unit
3: Syringe
5: Needle Hub
7: Needle
10: housing
11: first needle through hole
13: conductor guide slit
20: Needle hub coupling bushing
30: electrode fixed substrate
31: second needle through hole
33: electrode
35: lead wire
37: fastening screw
40: elastic coil spring
100: electroporation injector
110: body
111: control button
120: grip handle
121: trigger unit
130: cartridge
140: needle electrode withdrawing guide unit
150: syringe seat
160: syringe transfer mechanism
170: plunger support bar
180: forward and backward movement guide

Claims (5)

In the needle guide unit provided in the electroporation injector, which allows the chemical solution to easily penetrate into the body through the application of an electric field by the electrode at the same time as the injection of the chemical solution by the needle,
a housing which is installed movably back and forth on the front side of the electroporation injector, has a front open housing shape, and has a first needle through hole formed in the center of the rear surface;
a needle hub coupling bushing which is integrally coupled to protrude from the center of the rear surface of the housing and to which a needle hub connecting a syringe and the needle is detachably coupled; and
The electrode inserted into the housing and protruding forward is provided so as to apply a current, and in the center of which a second needle through hole through which the needle through the first needle through hole is penetrated is formed, it characterized in that it comprises an electrode fixing substrate Electroporation injector needle guide unit. The method according to claim 1,
A needle guide unit for an electroporation injector, characterized in that conducting wire guide slits are formed on both sidewalls of the housing, and a conducting wire for applying a current to the electrode fixing substrate is drawn out through the conducting wire guide slit. The method according to claim 1,
The electrode fixing substrate is a needle guide unit for an electroporation injector, characterized in that it is detachably coupled to the housing by a fastening screw. The method according to claim 1,
The needle guide unit of the electroporation injector, characterized in that the housing is made of a synthetic resin material, and the needle hub coupling bushing is made of a metal material or a synthetic resin material. 5. The method according to any one of claims 1 to 4,
Electroporation injector needle guide, characterized in that it further comprises an elastic coil spring which is coupled through the electrode and elastically biases the housing to which the electrode fixing substrate is inserted with respect to the front end side of the electroporation injector rearward. unit.

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