KR20220074353A - Compositions comprising Ecklonia cava extract for acceleration of gastric motility - Google Patents

Abstract

The present invention relates to a food composition for promoting gastrointestinal motility and a composition for adding feed, comprising an Ecklonia extract as an active ingredient. When administered to an animal with reduced gastrointestinal motility, the Ecklonia cava extract of the present invention promoted gastrointestinal motility, promoted the secretion of related hormones, and showed the effect of facilitating the secretion of mucin. It can be used as a composition taken for a long time to improve deterioration.

Description

Composition comprising Ecklonia cava extract for acceleration of gastric motility, comprising Ecklonia cava extract as an active ingredient

The present invention relates to a composition for facilitating gastrointestinal motility comprising an Ecklonia cava extract as an active ingredient.

Gastrointestinal motility disorders include gastroesophageal reflux, functional dyspepsia, irritable colitis, gastrointestinal paralysis, vomiting, diabetic gastrointestinal motility disorder, gastrointestinal motility disorder due to chemotherapy, intestinal obstruction due to gastrointestinal motility disorder, postoperative gastrointestinal obstruction including postoperative ileus. It refers to a condition in which normal gastrointestinal motility is impaired, inhibited, or impaired, such as dysfunction or gastrointestinal motility disorder due to myotonic dystrophy.

Gastrointestinal motility disorders occur quite frequently in developed countries as well as in Korea, and show a variety of symptoms. These gastrointestinal motility disorders are functional symptoms related to gastrointestinal peristalsis, not histopathological and biochemical lesions of the gastrointestinal tract.

Currently, gastrointestinal motility disorder is diagnosed through the diagnosis of various symptoms without a clear organic lesion, so the treatment is not simple, and most of the symptoms repeat improvement and exacerbation, and the changes are severe due to food and stress.

Currently, as representative gastrointestinal motility promoters, there are drugs such as domperidone, metoclopramide, levosulpiride, mosapride, and itopride.

Among them, metoclopramide, domperidone, cisapride, levosulpride, erythromycin, and other gastrointestinal motility stimulants are known in several studies to have excellent effects. , Metoclopramide is the most commonly used antidopamine drug, which inhibits dopamine receptors in the central nervous system and gastrointestinal tract. Dopamine plays a role in inhibiting gastrointestinal motility. Metoclopramide enhances gastroduodenal movement, improves gastric emptying, and has an analgesic action to improve symptoms of patients suffering from diseases caused by gastrointestinal motility disorders such as functional dyspepsia. and acts on dopamine receptors in the central nervous system, and may cause side effects of the nervous system in up to 24% of patients.

In particular, gastrointestinal motility disorders often require long-term use because improvement and deterioration are repeated.

The present inventors have completed the present invention by confirming that the natural product-derived extract promotes reduced gastrointestinal motility.

Accordingly, an object of the present invention is to provide a food composition for promoting gastrointestinal motility.

Another object of the present invention is to provide a method for preparing a food composition for promoting gastrointestinal motility.

Another object of the present invention is to provide a composition for adding feed for promoting gastrointestinal motility.

In order to achieve the above object, the present invention provides a food composition for promoting gastrointestinal motility comprising an extract of Ecklonia cava as an active ingredient.

In addition, in order to achieve the above another object, the present invention is Ecklonia cava pulverizing step for producing Ecklonia cava powder by pulverizing; Extraction step of circulating extraction of the Ecklonia cava powder; filtering the extracted Ecklonia cava extract; Concentrating the filtered Ecklonia extract to dryness; and diluting the dried and concentrated Ecklonia cava extract in a solvent; provides a method for producing a food composition for promoting gastrointestinal motility comprising.

In addition, in order to achieve the above another object, the present invention provides a composition for adding a feed for facilitating gastrointestinal motility comprising an Ecklonia cava extract as an active ingredient.

Ecklonia cava extract according to the present invention, when administered to animals with reduced gastrointestinal motility, promoted gastrointestinal motility, promoted the secretion of related hormones, and had the effect of promoting the secretion of mucin. It can be usefully used as an additive composition or the like.

1 is a result of confirming the constituents of Ecklonia cava extract according to the present invention using GC-MS (gas chromatograph-mass spectrometer).
2 is a result of confirming the components of the Ecklonia cava extract according to the present invention using FTIR (Fourier transform infrared spectroscopy).
Figure 3 is the result of confirming the effect of promoting intestinal movement of Ecklonia cava extract according to the present invention.
Figure 4 is the result of confirming the effect of stimulating the secretion of intestinal motility hormone of Ecklonia cava extract according to the present invention.
5 is a result confirming the mucin secretion promoting effect of Ecklonia cava extract according to the present invention.
6 is a result confirming the mucin-related gene expression promoting effect of the Ecklonia cava extract according to the present invention.

Hereinafter, the present invention will be described in detail.

The present invention provides a food composition for facilitating gastrointestinal motility comprising an Ecklonia cava extract as an active ingredient.

In the present invention, the Ecklonia cava is a seaweed of the scientific name Ecklonia cava, and belongs to the seaweed family of the brown algae plant kelp family. The middle part is thick and the inside is full when young, but sometimes the middle part is empty when grown up. The upper part of the stem is gradually flattened, and right upper lobes appear on both sides, and alternate upper right lobules are produced here. There are no wrinkles on the leaf surface. It is brown in color, but turns black when dried. It is mainly distributed around Jeju Island and some southern coasts, and inhabits at a depth of about 10m in the lunch zone. As a perennial plant that grows for 2-3 years, Ecklonia, which is the main food for abalone, contains a lot of nutrients such as alginic acid, iodine, and potassium, and is attracting attention as a health food resource.

The Ecklonia extract of the present invention can be extracted by a known natural extracting method, and the type of extraction solvent used for extraction is not particularly limited as long as it is known in the art as a solvent for extracting seaweed components, but preferably water. , lower alcohols having 1 to 6 carbon atoms (eg methanol, ethanol, propanol, butanol, pentanol, hexanol, glycerin, propylene glycol and 1,3-butylene glycol), lower ketones having 1 to 4 carbon atoms (eg. It may be extracted with one or more solvents selected from the group consisting of acetone, methyl ethyl ketone, etc.), lower esters having 1 to 4 carbon atoms (eg, ethyl acetate and butyl acetate, etc.), subcritical fluids and supercritical fluids, and more Preferably, it may be extracted with one or more solvents selected from the group consisting of water, lower alcohols having 1 to 6 carbon atoms, acetone, ethyl acetate, subcritical fluids and supercritical fluids. Most preferably, it may be extracted with one or more solvents selected from the group consisting of water, lower alcohols having 1 to 4 carbon atoms, and mixed solvents thereof.

The preparation of the Ecklonia cava extract may include a pretreatment process to increase extraction efficiency, for example, it may be used by drying Ecklonia cava and pulverizing it with a grinder.

The extraction temperature of the extract of the present invention is not particularly limited, and may be, for example, 0°C to 150°C, preferably 10°C to 80°C, and more preferably 30°C to 70°C. The extract extraction time of the present invention is not particularly limited as those skilled in the art can appropriately set and change according to the extraction temperature, and may be, for example, 10 minutes to 10 days, preferably 1 hour to 72 hours, more preferably may be 12 to 24 hours.

The extract of the present invention may be extracted by a known natural product extraction method. For example, circulation extraction, cold extraction, room temperature extraction, hot water extraction, reflux cooling extraction, heating extraction, high pressure extraction, ultrasonic extraction, subcritical extraction, supercritical extraction, etc. can be used to extract, preferably from 1 to 10 times. The extraction can be repeated 2 to 7 times.

In addition, filtration process, concentration and purification process, drying process, freezing process, powdering process, etc. may be arbitrarily added for ease of processing, storage, etc.

The filtration process may be performed by a known filtration method, but is not limited thereto, and for example, filtration using a filtration network or microfilter, centrifugation, and a separatory funnel may be used. The concentration process may be by a known concentration method, but is not limited thereto, and may be concentrated using, for example, precipitation concentration, evaporative concentration, reduced pressure concentration, ultrafiltration, reverse osmosis, and centrifugation.

The drying process may be by a known drying method, but is not limited thereto, and may be, for example, freeze drying, spray drying, or hot air drying. In addition, the powdering process may be performed by a known powdering method, but is not limited thereto, and may be powdered by, for example, a process such as dextrin inclusion.

Ecklonia cava extract of the present invention is characterized in that promoting gastrointestinal motility promotes gastrointestinal peristalsis (gastric motility) action.

According to one embodiment of the present invention, it was confirmed that when the Ecklonia cava extract according to the present invention was treated in an animal model with impaired gastrointestinal motility, the gastrointestinal transit increased in a concentration-dependent manner.

The “food” of the present invention may be prepared in any form, such as functional food, nutritional supplement, health food, and food additives. For example, as a health food, the Ecklonia cava extract of the present invention may be prepared and consumed in the form of tea, juice, and drink, or may be ingested by granulation, encapsulation and powdering. In addition, functional foods include beverages (including alcoholic beverages), fruits and their processed foods (eg, canned fruit, bottled, jam, marmalade, etc.), fish, meat, and their processed foods (eg, ham, sausage, corned beef, etc.) , breads and noodles (eg udon noodles, noodles, ramen, spaghetti, macaroni, etc.), fruit juice, various drinks, cookies, syrup, dairy products (eg butter, cheese, etc.), edible vegetable oils and fats, margarine, vegetable protein, retort food , frozen food, various seasonings (eg, soybean paste, soy sauce, sauce, etc.), etc. can be prepared by adding the extract of the present invention.

When the Ecklonia cava extract of the present invention is used in the form of a food composition, the food composition may be used as it is, or it may be added to other foods or used together with other foods or food ingredients, which may be appropriately used according to a conventional method. The mixed amount of the active ingredient may be appropriately determined according to the purpose of use (prevention, health or therapeutic treatment).

The food composition of the present invention may contain various flavoring agents or natural carbohydrates as additional ingredients. As the above-mentioned natural carbohydrates, monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, and natural sweeteners such as dextrin and cyclodextrin, synthetic sweeteners such as saccharin and aspartame may be used. . The proportion of the natural carbohydrate is generally about 0.01 to 0.4 g, preferably about 0.02 to 0.03 g per 100 ml of the composition of the present invention.

In addition to the above, the food composition of the present invention includes various nutrients, vitamins, electrolytes, flavoring agents, coloring agents, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohol , a carbonation agent used in carbonated beverages, and the like. In addition, the food composition of the present invention may contain fruit for the production of natural fruit juice, fruit juice beverage, and vegetable beverage. These components may be used independently or in combination. The proportion of these additives is generally selected from 0.01 to 0.1 parts by weight per 100 parts by weight of the composition of the present invention, but is not limited thereto.

In addition, the present invention is Ecklonia cava pulverization step for producing Ecklonia cava powder by pulverizing; Extraction step of circulating extraction of the Ecklonia cava powder; filtering the extracted Ecklonia cava extract; Concentrating the filtered Ecklonia extract to dryness; and diluting the dried and concentrated Ecklonia cava extract in a solvent; It provides a method for producing a food composition for promoting gastrointestinal motility comprising a.

The circulation extraction may be performed at 30 to 70° C. for 12 to 48 hours, but is not limited thereto, and more preferably at 50° C. for 24 hours, but is not limited thereto.

In addition, the filtration may be performed using a filtration filter having a filtration size of 0.2 to 0.6 μm, but is not limited thereto. More preferably, it may be performed using a filtration filter having a filtration size of 0.4 μm, but this It is not limited.

In addition, the present invention provides a composition for adding a feed for promoting gastrointestinal motility comprising the Ecklonia cava extract as an active ingredient.

As used herein, the term "feed" refers to any natural or artificial Chinese food eaten by animals, such as one meal meal, or a component of the one meal meal, and a feed containing the composition for promoting gastrointestinal motility according to the present invention as an active ingredient is It can be prepared in various types of feed known in the art, and preferably, it may include, but is not limited to, a concentrated feed, roughage and/or special feed.

In the present invention, the term "composition for feed addition" may mean "feed additive", which in animals relieves disease symptoms, supplements nutrients and prevents weight loss, enhances digestibility of fiber in feed, improves oil quality, breeding It includes substances added to feed for the purpose of various effects, such as preventing disorders, improving fertility, and preventing high temperature stress in summer.

The composition for feed addition of the present invention corresponds to an auxiliary feed under the Feed Management Act, and mineral preparations such as sodium bicarbonate, bentonite, magnesium oxide, and complex minerals, and trace minerals such as zinc, copper, cobalt, and selenium. , kerotene, vitamins A, D, E, nicotinic acid, vitamin B complex, etc., protective amino acids such as methionine and lysine, protective fatty acids such as fatty acid calcium salts, probiotics (lactic acid bacteria), yeast cultures, mold fermented products, etc. Live bacteria, yeast agents, etc. may be further included.

Among the feeds, the enriched feed includes seed fruits containing grains such as wheat, oats, and corn, bran containing rice bran, bran, barley bran, etc. Sesame cakes, which are by-products obtained from oil extraction of palms, etc., residual starches, which are the main components of starch residues, which are the remainder after removing starch from sweet potatoes and potatoes, fish meal, fish residues, and fresh liquids obtained from fish. Animal substances such as dried whey, which is the residue from the production of concentrated fish soluble, meat meal, blood meal, down feather, skim milk powder, milk, and casein from skim milk Feed, yeast, chlorella, seaweed, but not limited thereto.

Among the feeds, forage includes raw grass feed such as wild grass, grass, green cut crops, turnips for feed, beets for feed, root vegetables such as Luther Bearger, which is a type of turnip, raw herbs, green crops, and grains. Examples include, but are not limited to, silage, which is stored feed fermented with lactic acid after filling a silo with a back, wild grass, hay obtained by cutting and drying grass, straw for breeding crops, and leaves of legumes. Special feed includes mineral feed such as oyster shells and rock salt, urea feed such as urea or its derivative diureide isobutane, supplementing ingredients that are easily lacking when only natural feed raw materials are mixed, or added to formulated feed to increase feed storage. There are feed additives and dietary supplements, which are substances added in trace amounts, but are not limited thereto.

The composition for feed addition according to the present invention can be prepared by adding Ecklonia cava extract in an appropriate effective concentration range according to various feed preparation methods known in the art.

The feed additive according to the present invention can be applied without limitation as long as it is an individual for the purpose of promoting gastrointestinal motility. For example, non-human animals such as monkeys, dogs, cats, rabbits, guinea pigs, rats, mice, cattle, sheep, pigs, goats, etc., birds and fish can be applied to any object.

The above-described contents of the present invention are equally applied to each other as long as they do not contradict each other, and those skilled in the art to implement with appropriate changes are also included in the scope of the present invention.

Hereinafter, the present invention will be described in detail through Examples, but the scope of the present invention is not limited only to the Examples below.

Example 1. Preparation of Ecklonia cava extract

A dried sample of Ecklonia cava was obtained from Parajeju Com. It was purchased from (Jeju, Korea), and a sample of Ecklonia (WPC-19-001) voucher was deposited at the Functional Materials Bank of Pusan National University Well-being RIS Center. After pulverizing the dried Ecklonia cava using a grinder (MF-3100S, Hanil Electric Co., Seoul), circulation extraction equipment (SHWB-30/45, Woori Science Instrument Co., Pocheon) was used at 50 ° C for 24 hours. and extracted with a fixed solution ratio (Ecklonia cava dry powder: dH ₂ O, 1:10). After that, the extract was filtered through a 0.4 μ filter, dried using a rotary evaporator (EYELA, Tokyo, Japan), and stored at -80°C until use. And according to the experimental concentration, 200 mg of low concentration and 400 mg of high concentration were diluted in dH ₂ O to prepare an Ecklonia extract.

Example 2. Analysis of components of Ecklonia cava extract

The total tannin content of the Ecklonia cava extract prepared in Example 1 was measured using the Vanillin method. First, Ecklonia cava extract (100 uL) was mixed with 500 uL of a mixed solution (1% vanillin/MeOH and 8% HCl/MeOH, 1:1 ratio), and then incubated at 30° C. for 20 minutes. After incubation, absorbance was measured at 500 nm using a VersaMax plate reader (Molecular Devices). The total condensed tannin content was calculated from a calibration curve constructed using a purified (+)-catechin hydrate standard ((+)-catechin hydrate standard (Sigma-Aldrich Co.)), and the results are shown in Table 1 below.

classification Concentration (mg/g) Total flavonoid content 34.9±0.2 Total phenol content 74.6±0.6 Total condensed tannin content 326.5±12.2

The total condensed tannin content of the E. E. extract was 326.5±12.2 mg/g, which was confirmed to be about ten times higher than the total flavonoid content (34.9 mg/g) and the total phenol content (74.6 mg/g).

In addition, the components of the Ecklonia cava extract were analyzed using gas chromatograph-mass spectrometer (GC-MS) and Fourier transform infrared spectroscopy (FTIR). GC-MS (QP-2010A, Shimadzu, Japan) equipped with an automatic thermal desorption device (ATD 400, Perkin Elmer, UK) was used, and the capillary column AT-1 was 60 m × 0.32 mm × 1.0 mm with a mass range of 20 - 350 m/z. FTIR spectroscopy (Impact 400D, Nicolet, Madison, WI, USA) showed that 32 scans were collected in transmission mode at 4 cm ⁻¹ resolution between 400 and 4000 cm ⁻¹ for each IR spectrometer sample.

As a result, as shown in Figure 1, the main components of the Ecklonia extract are carbamic acid, ethanol, acetone, toluene, decanal, silicate anion tetramer ( silicate anion tetramer), was identified as n-nonanal. In addition, as a result of confirming using FTIR, as shown in Figure 2, alcohol (3274cm ^-1 ), cellulose and tannin (2971 and 2948cm ^-1 ), lignin and tannin (1608 and 1521 cm ^-1 ), etc. It was confirmed that the presence of Ecklonia cava extract did.

Example 3. Confirmation of intestinal motility promoting effect of Ecklonia cava extract

Gastrointestinal transit was analyzed to confirm the intestinal motility promoting function of the E. E. extract. First, SD rats were classified into three groups (control group: Vehicle group, low-concentration Ecklonia cava extract group (WELo group), high-concentration Ecklonia cava extract group (WEHi group). Then, loperamide was administered to the rats of each experimental group. After administration, 3 ml of charcoal (3% activated charcoal suspension in 0.5% aqueous methylcellulose (Sigma-Aldrich Co.)) was orally administered after 30 minutes. The intestines of euthanized rats were collected, the total length of the intestine and the movement distance of activated carbon were measured, and the movement rate of food in the intestine was calculated as follows.

[Equation 1]

Movement rate of intestinal food (%) = [(length of small intestine - movement distance of activated carbon)/length of total small intestine)] × 100

As a result, as shown in FIG. 3, the movement of activated carbon was increased in a concentration-dependent manner in the WELo and WEHi groups to which Ecklonia was administered compared to the Vehicle group in which gastrointestinal motility was inhibited. In addition, it was confirmed that the length of the intestine was recovered in the animals treated with the Ecklonia cava extract. Therefore, it was confirmed that the Ecklonia cava extract according to the present invention can restore the decreased intestinal motility.

Example 4. Confirmation of the intestinal motility hormone secretion promoting effect of Ecklonia cava extract

In the expression of intestinal motility hormone secreted by the large intestine, the effect of the Ecklonia cava extract according to the present invention was confirmed. In order to measure the expression of intestinal motility hormones, cholecystokinin (CCK), gastrin, and somatostatin (SS), an ELISA kit (Cusabio Biotech Co., Ltd., Wuhan, China) was used. After quantifying 100 mg of colonic tissue, 1 ml of phosphate buffered saline (PBS, pH 7.2-7.4) stored on ice was added and pulverized, followed by centrifugation at 4° C. at 1,000 x g for 5 minutes, and the supernatant. obtained. To this, the three types of hormonal antibodies (separately to each well) were added, and after incubation at 37°C for 1 hour, HRP-Streptavidin solution was added and further incubated at 37°C for 1 hour. did. Then, after adding TMP One-Step Substrate Reagent and reacting at 37° C. for 30 minutes, a stop solution was added to stop the reaction. Thereafter, the absorbance was measured at 450 nm using a Molecular Devices VERSA max Plate reader (Sunnyvale, CA, USA).

As a result, as shown in FIG. 4 , the concentration of three types of intestinal hormones was significantly decreased in the Vehicle group in which gastrointestinal motility was inhibited, but increased in a concentration-dependent manner in the WELo and WEHi groups administered with the Ecklonia cava extract according to the present invention. Therefore, it was confirmed that the Ecklonia cava extract according to the present invention has an effect of restoring the decreased concentration of intestinal motility hormone due to decreased gastrointestinal motility.

Example 5. Confirmation of mucin secretion promoting effect of Ecklonia cava extract

Alcian blue staining was performed according to a known method in order to confirm the effect of the E. coccyx extract of the present invention on the secretion of mucin in the colon. Alcian blue staining analysis involves immersing the sliced tissue in xylene 3 times for 3 minutes each, immersing them in 100% alcohol for 2 minutes and 1 minute, respectively, and then immersing them in 95, 80, and 70% alcohol for 1 minute and 30 seconds, respectively. After washing with water for 1 minute, it was stained using an Alcian Blue Stain kit (IHC WORLD, Woodstock, MD, USA). After fixing the slides, they were dried and observed using a BX50F-3 microscope (Olympus, Tokyo, Japan), and analyzed using the Leica Application Suite (Leica Microsystems, Wetzlar, Germany).

As a result, as shown in FIG. 5, the secretion of mucin from the colonic crypt was decreased in the Vehicle group in which gastrointestinal motility was inhibited, but significantly increased in the WELo group and WEHi group administered with the Ecklonia cava extract according to the present invention. did Therefore, it was confirmed that the Ecklonia cava extract according to the present invention has the effect of promoting mucin secretion.

Example 6. Confirmation of mucin-related gene expression promotion effect of Ecklonia cava extract

The effect of the Ecklonia cava extract according to the present invention on the expression of the mucin gene was confirmed by performing qRT-PCR. qRT-PCR was performed by isolating RNA from rat colon tissue. 300 mg of colonic tissue from SD rats was extracted and pulverized using a homogenizer, and then RNA was extracted. The protein contained in the RNAzol extract was harvested by extracting the RNA using chloroform and then precipitating the RNA using isopropanol. The absorbance of the isolated total RNA was measured at 260 nm, and 5 μg was used. First, 5 μg of RNA was treated with Oligo dT (invitrogen, 18418-012), and reacted at 70° C. for 10 minutes to bind Oligo dT to RNA. 5x buffer, 10 mM dNTP, 0.1 M DTT, and Superscript II (Invitrogen, 18064-014, 200 U/μl) were added thereto, left at room temperature for 10 minutes, and then reacted at 42° C. for 50 minutes. After the reaction was completed, RNA was decomposed by treatment with RNaseH (Invitrogen, 18021-071) and reacting at 37° C. for 20 minutes. qPCR was performed with the obtained cDNA template (2 μL) and 2x Power SYBR Green (6 μL; Toyobo Life Science, Osaka, Japan) containing the following primers. 94 ℃ (15 sec), 70 ℃ (60 sec) was carried out 40 times (cycle), primer for MUC2 (5'TCCTG TGGCA TCCAT GAAAC-3' β-actin (β-actin) for primer (5') CGCAG CTCAG TAACA GTCCG-3' was used. In addition, the reaction cycle in which the PCR product exceeds the fluorescence intensity threshold in the exponential phase of PCR amplification was regarded as the threshold cycle (Ct). By comparing Cts at a constant fluorescence intensity, Expression of the target gene was quantified by comparison with β-actin.

As a result, as shown in FIG. 6, the expression of the mucin gene was decreased in the Vehicle group in which gastrointestinal motility was inhibited, but significantly increased in the experimental group treated with the Ecklonia cava extract of the present invention. Therefore, it was confirmed that the Ecklonia cava extract according to the present invention has the effect of promoting the expression of the mucin gene.

Overall, the present invention confirms the gastrointestinal motility promoting effect of the Ecklonia cava extract, and when administered to animals with reduced gastrointestinal motility, the Ecklonia cava extract according to the present invention promotes gastrointestinal motility, promotes the secretion of related hormones, and inhibits the secretion of mucin. Since it showed the effect of promoting it, it can be usefully used as a food composition for promoting gastrointestinal motility, a composition for adding feed, and the like.

Claims (8)

A food composition for facilitating gastrointestinal motility comprising an Ecklonia cava extract as an active ingredient.
The method of claim 1,
The Ecklonia extract is characterized in that extracted with one or more solvents selected from the group consisting of water, alcohols having 1 to 6 carbon atoms, and mixed solvents thereof, a food composition.
The method of claim 1,
The gastrointestinal motility promotion is characterized in that the gastrointestinal peristalsis (gastric motility) to promote action, a food composition.
The method of claim 1,
The food composition is characterized in that any one selected from the group consisting of functional food (functional food), nutritional supplements (nutritional supplement), health food (health food) and food additives (food additives), food composition.
Ecklonia cava pulverization step of pulverizing Ecklonia cava to produce Ecklonia cava powder;
Extraction step of circulating extraction of the Ecklonia cava powder;
filtering the extracted Ecklonia cava extract;
Concentrating the filtered Ecklonia extract to dryness; and
Method for producing a food composition for promoting gastrointestinal motility comprising a;
6. The method of claim 5,
The circulation extraction is characterized in that carried out for 12 to 48 hours at 30 to 70 ℃, the manufacturing method.
6. The method of claim 5,
The filtration is characterized in that it is performed using a filtration filter having a filtration size of 0.2 to 0.6 ㎛, the manufacturing method.
A composition for adding a feed for promoting gastrointestinal motility comprising an Ecklonia extract as an active ingredient.

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