KR20220058245A - Open Magnetic Particle Imaging Apparatus - Google Patents

Abstract

The present invention relates to an open-type magnetic particle imaging apparatus. According to one embodiment of the present invention, the open-type magnetic particle imaging apparatus may comprise: a selection coil unit generating a field free line (FFL) for a nano particle in a first direction; a first drive coil unit generating a magnetic field in a second direction to move the FFL in a third direction; a second drive coil unit generating a magnetic field in the third direction to move the FFL in the second direction; an excitation coil unit for oscillating the nano particle; and a receiver coil unit for detecting a signal for the nano particle.

Description

Open Magnetic Particle Imaging Apparatus

The present invention relates to an open magnetic particle imaging apparatus, and more particularly, to an open magnetic particle imaging apparatus using a magnetic field coil.

In general, non-invasive imaging equipment widely used in medical and industrial fields is X-ray or X-ray CT (Computed to Mography), ultrasound imaging equipment, PET (Positron Emission Tomography) using radioactive materials, magnetic field-based It can be broadly divided into video equipment of

Magnetic Particle Imaging (MPI) is an imaging method for imaging nanoparticles of interest. Nanoparticles may be injected intravenously or orally administered to a patient/object. There are several potential uses for medical imaging, such as angiography, stem cell tracking, and tumor detection.

However, research for more efficient imaging of such magnetic particles is insufficient.

[Patent Document 1] Korean Patent Publication No. 10-2020-0070971

The present invention was created to solve the above problems, and an object of the present invention is to provide an open magnetic particle imaging apparatus.

Another object of the present invention is to provide an open magnetic particle imaging apparatus for controlling a Field Free Line (FFL) through a magnetic field.

Objects of the present invention are not limited to the objects mentioned above, and other objects not mentioned will be clearly understood from the description below.

In order to achieve the above objects, an open magnetic particle imaging apparatus according to an embodiment of the present invention includes a selection coil unit for generating FFL (Field Free Line) for nanoparticles in a first direction; a first drive coil unit generating a magnetic field in a second direction to move the FFL in a third direction; a second drive coil unit generating a magnetic field in the third direction to move the FFL in a second direction; an excitation coil unit for oscillating the nanoparticles; and a receiver coil unit for detecting a signal for the nanoparticles.

In an embodiment, the selection coil unit and the first drive coil unit may rotate in the same direction.

In an embodiment, the selection coil unit includes first and second lower selection coils and first and second upper selection coils positioned on the first and second lower selection coils, and the first and second lower Each of the selection coil and the first and second upper selection coils may include a core member.

In an embodiment, the first upper selection coil may be disposed parallel to a side surface of the second upper selection coil, and the first lower selection coil may be disposed parallel to a side surface of the second lower selection coil.

In an embodiment, the first drive coil unit may include first and second lower drive coils and first and second upper drive coils positioned on the first and second lower drive coils.

In an embodiment, the first upper drive coil may be disposed parallel to a side surface of the second upper drive coil, and the first lower drive coil may be disposed parallel to a side surface of the second lower drive coil.

In an embodiment, the second drive coil unit may include a third lower drive coil and a third upper drive coil positioned on the third lower drive coil.

In an embodiment, the excitation coil unit may include a first lower excitation coil and a first upper excitation coil positioned on the first lower excitation coil.

In an embodiment, the receiver coil unit may include a lower receiver coil and an upper receiver coil positioned on the lower receiver coil.

In an embodiment, the first and second lower drive coils are positioned on the first and second lower selection coils, the third lower drive coil is positioned on the first and second lower drive coils, and the third The first lower excitation coil may be positioned on a lower drive coil, and the lower receiver coil may be positioned on the first lower excitation coil.

In an embodiment, the upper receiver coil is positioned on the lower receiver coil, the first upper excitation coil is positioned on the upper receiver coil, the third upper drive coil is positioned on the first upper excitation coil, and the The first and second upper drive coils may be positioned on a third upper drive coil, and the first and second lower selection coils may be positioned on the first and second upper drive coils.

In an embodiment, a field of view (FOV) may be formed between the lower receiver coil and the upper receiver coil, and the nanoparticles may be positioned inside the FOV.

In an embodiment, the open magnetic particle imaging device includes a fourth lower drive coil positioned parallel to the third lower drive coil, and a second lower drive coil positioned on the fourth lower drive coil and positioned parallel to the first lower excitation coil. a lower excitation coil, a lower attenuation coil over the second lower excitation coil and parallel to the lower receiver coil, an upper attenuation coil over the lower attenuation coil and parallel to the upper receiver coil, the upper attenuation coil Attenuation comprising: a second upper excitation coil positioned on and positioned parallel to the first upper excitation coil, a fourth upper drive coil positioned on the second upper excitation coil and positioned parallel to the third upper drive coil; The unit may further include, wherein a winding direction of the upper and lower receiver coils and a winding direction of the upper attenuation coil and the lower attenuation coil may be opposite to each other.

In an embodiment, the attenuator may attenuate the signal of the receiver coil unit.

In an embodiment, the open magnetic particle imaging apparatus includes a lower metal member for removing magnetic field interference between the first and second lower selection coils and the first and second lower drive coils, and the first and second upper selection coils and a metal member including an upper metal member for removing magnetic field interference between the first and second upper drive coils.

Specific details for achieving the above objects will become clear with reference to the embodiments to be described in detail below in conjunction with the accompanying drawings.

However, the present invention is not limited to the embodiments disclosed below, it may be configured in various different forms, and those of ordinary skill in the art to which the present invention belongs ( Hereinafter, "a person skilled in the art") is provided to fully inform the scope of the invention.

According to an embodiment of the present invention, it is possible to obtain an MPI image of the nanoparticles by controlling the FFL through a magnetic field.

Effects of the present invention are not limited to the above-described effects, and potential effects expected by the technical features of the present invention will be clearly understood from the following description.

1 is a view showing a side view of an open magnetic particle imaging apparatus according to an embodiment of the present invention.
2 is a diagram illustrating a perspective view of an open magnetic particle imaging apparatus according to an embodiment of the present invention.
3A and 3B are diagrams illustrating FFL generation of a selection coil unit according to an embodiment of the present invention.
3c and 3d are views illustrating a selection coil unit composed of a permanent magnet according to an embodiment of the present invention.
4A to 4C are diagrams illustrating magnetic field induction of a first drive coil unit according to an embodiment of the present invention.
4D and 4E are diagrams illustrating FFL generation by the selection coil unit and the first drive coil unit according to an embodiment of the present invention.
5A to 5C are diagrams illustrating magnetic field induction of a second drive coil unit according to an embodiment of the present invention.
5D and 5E are diagrams illustrating FFL generation by the selection coil unit and the second drive coil unit according to an embodiment of the present invention.
5F is a diagram illustrating FFL generation by the selection coil unit and the first and second drive coil units according to an embodiment of the present invention.
6A and 6B are diagrams illustrating FFL generation according to rotation of a selection coil unit and a first drive coil unit according to an embodiment of the present invention.
7A to 7C are diagrams illustrating magnetic field induction of an excitation coil unit according to an embodiment of the present invention.
8A to 8C are diagrams illustrating a receiver coil unit according to an embodiment of the present invention.
9A and 9B are diagrams illustrating magnetic field interference control of a metal member according to an embodiment of the present invention.
10A and 10B are diagrams illustrating signal detection for the presence or absence of nanoparticles according to an embodiment of the present invention.
11 is a diagram illustrating an open magnetic particle imaging system according to an embodiment of the present invention.

Since the present invention can have various changes and can have various embodiments, specific embodiments are illustrated in the drawings and described in detail.

Various features of the invention disclosed in the claims may be better understood upon consideration of the drawings and detailed description. The apparatus, methods, preparations, and various embodiments disclosed herein are provided for purposes of illustration. The disclosed structural and functional features are intended to enable those skilled in the art to specifically practice the various embodiments, and are not intended to limit the scope of the invention. The disclosed terms and sentences are for the purpose of easy-to-understand descriptions of various features of the disclosed invention, and are not intended to limit the scope of the invention.

In describing the present invention, if it is determined that a detailed description of a related known technology may unnecessarily obscure the gist of the present invention, the detailed description thereof will be omitted.

Hereinafter, an open magnetic particle imaging apparatus according to an embodiment of the present invention will be described.

1 is a view showing a side view of an open magnetic particle imaging apparatus 100 according to an embodiment of the present invention. 2 is a diagram illustrating a perspective view of an open magnetic particle imaging apparatus 100 according to an embodiment of the present invention.

1 and 2, the open magnetic particle imaging apparatus 100 includes a selection coil 101, a first drive coil 102, a second drive coil 103, It may include an excitation coil unit 104 , a receiver coil unit 105 , a metal member 106 , and a cancellation unit 201 .

The selection coil unit 101 may generate a Field Free Line (FFL) for the nanoparticles in the first direction. Here, the first direction may refer to a y-axis direction by a Cartesian coordinate system with respect to the open magnetic particle imaging apparatus 100 . However, the ordinal numbers of the first, second, third, etc. are in an arbitrary order, and the order is not limited thereto.

In an embodiment, the selection coil unit 101 may include first and second lower selection coils 111 and 112 and first and second upper selection coils 113 and 114 .

As used herein, when referring to being “on” or “over” a coil, layer, or member, it may be located directly on the coil, layer, or member, or another coil or intermediate layer may exist in between. Also, when a coil or layer is referred to as being “on” or “over” another coil, layer or member, it may be understood that it may cover the entire coil, layer, or member or cover a portion of the coil, layer or member. there is.

In this case, each of the first and second lower selection coils 111 and 112 and the first and second upper selection coils 113 and 114 may include a core member 115 , 116 , 117 , and 118 .

The first drive coil unit 102 may generate a magnetic field in the second direction to move the FFL in the third direction.

Here, the second direction may refer to the x-axis direction by the Cartesian coordinate system with respect to the open magnetic particle imaging apparatus 100 . However, the ordinal numbers of the first, second, third, etc. are in an arbitrary order, and the order is not limited thereto.

In an embodiment, the first drive coil unit 102 may include first and second lower drive coils 121 and 122 and first and second upper drive coils 123 and 124 .

In one embodiment, the selection coil unit 101 and the first drive coil unit 102 may rotate in the same direction.

The second drive coil unit 103 may generate a magnetic field in the third direction to move the FFL in the second direction.

Here, the third direction may refer to the z-axis direction by the Cartesian coordinate system with respect to the open magnetic particle imaging apparatus 100 . However, the ordinal numbers of the first, second, third, etc. are in an arbitrary order, and the order is not limited thereto.

In an embodiment, the second drive coil unit 103 may include a third lower drive coil 131 and a third upper drive coil 132 .

The excitation coil unit 104 may be used to oscillate nanoparticles.

In one embodiment, the excitation coil unit 104 may include a first lower excitation coil 141 and a first upper excitation coil 142 .

The receiver coil unit 105 may detect a signal for nanoparticles.

In an embodiment, the receiver coil unit 105 may include a lower receiver coil 151 and an upper receiver coil 152 .

In an embodiment, the first and second lower drive coils 121 and 122 may be positioned on the first and second lower selection coils 111 and 112 . Also, the third lower drive coil 131 may be positioned on the first and second lower drive coils 121 and 122 . Also, the first lower excitation coil 141 may be positioned on the third lower drive coil 131 . Also, a lower receiver coil 151 may be positioned on the first lower excitation coil 141 . Also, the upper receiver coil 152 may be positioned on the lower receiver coil 151 .

In one embodiment, the first upper excitation coil 142 may be positioned on the upper receiver coil 152 . Also, a third upper drive coil 132 may be positioned on the first upper excitation coil 142 . Also, the first and second upper drive coils 123 and 124 may be positioned on the third upper drive coil 132 . Also, the first and second lower selection coils 113 and 114 may be positioned on the first and second upper drive coils 123 and 124 .

In an embodiment, a field of view (FOV) may be formed between the lower receiver coil 151 and the upper receiver coil 152 . In this case, nanoparticles may be located inside the FOV.

In an embodiment, the metal member 106 may include a lower metal member 161 and an upper metal member 162 . For example, the metal member 106 may be formed of a copper plate.

In an embodiment, the attenuation unit 201 may include a second drive coil unit 203 , an excitation coil unit 204 , and an attenuation coil unit 206 .

In this case, the second drive coil unit 203 may include a fourth lower drive coil 231 and a fourth upper drive coil 232 .

The excitation coil unit 204 may include a second lower excitation coil 241 and a second upper excitation coil 242 .

The attenuation coil unit 206 may include a lower attenuation coil 261 and an upper attenuation coil 262 .

More specifically, in an embodiment, the fourth lower drive coil 231 may be positioned parallel to the third lower drive coil 131 .

Also, the second lower excitation coil 241 may be positioned on the fourth lower drive coil 231 and may be positioned parallel to the first lower excitation coil 151 .

In addition, the lower attenuation coil 261 may be positioned on the second lower excitation coil 241 and parallel to the lower receiver coil 151 .

In addition, the upper attenuation coil 262 may be located on the lower attenuation coil 261 and parallel to the upper receiver coil 152 .

Also, the second upper excitation coil 242 may be positioned on the upper attenuation coil 262 and positioned parallel to the first upper excitation coil 142 .

In addition, the fourth upper drive coil 232 may be positioned on the second upper excitation coil 242 and parallel to the third upper drive coil 132 .

In this case, the winding directions of the upper receiver coil 152 and the lower receiver coil 151 and the winding directions of the upper attenuation coil 262 and the lower attenuation coil 261 may be opposite to each other. Through this, the attenuator 201 may attenuate the signal of the receiver coil unit 105 .

3A and 3B are diagrams illustrating FFL generation of the selection coil unit 101 according to an embodiment of the present invention. 3c and 3d are diagrams showing the selection coil unit 101 composed of a permanent magnet 310 according to an embodiment of the present invention.

Referring to FIGS. 3A and 3B , the selection coil unit 101 may generate FFLs for nanoparticles in a first direction.

In one embodiment, the selection coil unit 101 is located on the first and second lower selection coils 111 and 112 and the first and second lower selection coils 111 and 112 first and second upper selection It may include coils 113 and 114 .

The first lower selection coil 111 may be disposed parallel to the side surface of the second lower selection coil 112 .

Also, the first upper selection coil 113 may be disposed parallel to the side surface of the second upper selection coil 114 .

In this case, current I in opposite directions may flow through the first lower selection coil 111 and the second lower selection coil 112 . In addition, in the first upper selection coil 113 , current I in opposite directions to the second upper selection coil 114 may flow.

For example, current may flow in the first lower selection coil 111 and the first upper selection coil 113 in a clockwise direction, and the second lower selection coil 112 and the second upper selection coil 114 are half Current can flow in a clockwise direction.

In one embodiment, referring to FIGS. 3C and 3D , the selection coil unit 101 may be configured as a permanent magnet 310 .

4A to 4C are diagrams illustrating magnetic field induction of the first drive coil unit 102 according to an embodiment of the present invention. 4D and 4E are diagrams illustrating FFL generation by the selection coil unit 101 and the first drive coil unit 102 according to an embodiment of the present invention.

4A to 4C , the first drive coil unit 102 may generate a magnetic field in the second direction. For example, a uniform magnetic field may be formed in the x-axis direction at a high frequency up to 1 kHz.

The first drive coil unit 102 includes first and second lower drive coils 121 and 122 and first and second upper drive coils 123 positioned on the first and second lower drive coils 121 and 122 . , 124) may be included.

The first lower drive coil 121 may be disposed parallel to a side surface of the second lower drive coil 122 . Also, the first upper drive coil 123 may be disposed parallel to a side surface of the second upper drive coil 124 .

In this case, both clockwise and counterclockwise AC currents may flow through the first and second lower drive coils 121 and 122 and the first and second upper drive coils 123 and 124 through matching.

4D and 4E , the first drive coil unit 102 may generate a magnetic field in the second direction to move the FFL in the third direction.

For example, the first drive coil unit 102 may generate a magnetic field in the x-axis direction to move the FFL in the z-axis direction.

In this case, the magnetic field by the first drive coil unit 102 may be combined with the selection field by the selection coil unit 101 .

5A to 5C are diagrams illustrating magnetic field induction of a second drive coil unit according to an embodiment of the present invention. 5D and 5E are diagrams illustrating FFL generation by the selection coil unit and the second drive coil unit according to an embodiment of the present invention. 5F is a diagram illustrating FFL generation by the selection coil unit and the first and second drive coil units according to an embodiment of the present invention.

5A to 5C , the second drive coil unit 103 may generate a magnetic field in a third direction. For example, a uniform magnetic field may be formed in the z-axis direction at a high frequency up to 25 kHz.

The second drive coil unit 103 may include a third lower drive coil 131 and a third upper drive coil 132 positioned on the third lower drive coil 131 .

In this case, both clockwise and counterclockwise AC currents may flow through the third lower drive coil 131 and the third upper drive coil 132 through matching.

5D and 5E , the second drive coil unit 103 may generate a magnetic field in the third direction to move the FFL in the second direction.

For example, the second drive coil unit 103 may generate a magnetic field in the z-axis direction to move the FFL in the x-axis direction.

In this case, the magnetic field by the second drive coil unit 103 may be combined with the selection field by the selection coil unit 101 .

Referring to FIG. 5F , the FFL may be formed in a Cartesian trajectory within the FOV. In this case, the magnetic field by the second drive coil unit 103 may be combined with the selection field by the selection coil unit 101 and the magnetic field by the first drive coil unit 102 .

6A and 6B are diagrams illustrating FFL generation according to rotation of the selection coil unit 101 and the first drive coil unit 102 according to an embodiment of the present invention.

6A and 6B , in the open magnetic particle imaging apparatus 100 , the selection coil unit 101 and the first drive coil unit 102 may rotate in the same direction.

For example, the selection coil unit 101 and the first drive coil unit 102 may rotate in a clockwise direction with respect to the z-axis direction. Through this, the open magnetic particle imaging apparatus 100 may acquire a 3D MPI image of nanoparticles through FFL.

7A to 7C are diagrams illustrating magnetic field induction of an excitation coil unit according to an embodiment of the present invention.

7A to 7C , the excitation coil unit 104 may oscillate nanoparticles. Also, the excitation coil unit 104 may generate a magnetic field in the third direction. For example, a uniform magnetic field may be formed in the z-axis direction at a high frequency up to 40 kHz.

The excitation coil unit 104 may include a first lower excitation coil 141 and a first upper excitation coil 142 positioned on the first lower excitation coil 141 .

In this case, both clockwise and counterclockwise AC currents may flow through the first lower excitation coil 141 and the first upper excitation coil 142 through matching.

8A to 8C are diagrams illustrating a receiver coil unit according to an embodiment of the present invention.

8A to 8C , the receiver coil unit 105 may include a lower receiver coil 151 and an upper receiver coil 152 positioned on the lower receiver coil 151 .

An FOV may be formed between the lower receiver coil 151 and the upper receiver coil 152 , and the nanoparticles may be positioned inside the FOV. In this case, uniform sensitivity of the receiver coil unit 105 may be formed.

For example, the receiver coil unit 105 may form a spiral coil.

9A and 9B are diagrams illustrating magnetic field interference control of a metal member according to an embodiment of the present invention.

9A and 9B , the metal member 106 may include a lower metal member 161 and an upper metal member 162 .

In an embodiment, the upper metal member 162 may be positioned between the first and second upper drive coils 123 and 124 and the first and second upper selection coils 113 and 114 .

In an embodiment, the upper metal member 162 may remove magnetic field interference between the first and second upper drive coils 123 and 124 and the first and second upper selection coils 113 and 114 .

In an embodiment, the lower metal member 161 may be positioned between the first and second lower drive coils 121 and 122 and the first and second lower selection coils 111 and 112 .

In an embodiment, the lower metal member 161 may remove magnetic field interference between the first and second lower drive coils 121 and 122 and the first and second lower selection coils 111 and 112 .

That is, the metal member 106 can isolate a high magnetic field and a static magnetic field and reduce noise from the outside.

10A and 10B are diagrams illustrating signal detection for the presence or absence of nanoparticles according to an embodiment of the present invention.

10A and 10B , the receiving unit (ie, group 1) may include a second drive coil unit 103 , an excitation coil unit 104 , and a receiver coil unit 105 .

The attenuation unit (ie, group 2) may include a second drive coil unit 203 , an excitation coil unit 204 , and an attenuation coil unit 206 .

In this case, the winding direction of the receiver coil unit 105 and the winding direction of the attenuation coil unit 206 may be opposite to each other. In addition, the distance between the receiver and the attenuator may be sufficiently spaced to remove the influence of each other.

In this case, referring to FIG. 10A , when nanoparticles are not present, the voltage induced in the receiver coil unit 105 may be expressed as in Equation 1 below.

는 수신기 코일부(105)에서 유도되는 전압,

는 제2 드라이브 코일부(103)에 의해 유도되는 전압,

는 여기 코일부(104)에 의해 유도되는 전압을 나타낸다. here,

is the voltage induced in the receiver coil unit 105,

is the voltage induced by the second drive coil unit 103,

denotes the voltage induced by the excitation coil unit 104 .

Also, in an embodiment, the voltage induced by the attenuation coil unit 206 may be expressed as in Equation 2 below.

는 감쇄 코일부(206)에 의해 유도되는 전압,

는 제2 드라이브 코일부(203)에 의해 유도되는 전압,

는 여기 코일부(204)에 의해 유도되는 전압을 나타낸다. here,

is the voltage induced by the attenuation coil unit 206,

is the voltage induced by the second drive coil unit 203,

denotes the voltage induced by the excitation coil unit 204 .

In an embodiment, since the receiver coil unit 105 and the attenuation coil unit 206 are connected in series, the voltage of the received signal may be expressed as in Equation 3 below.

는 수신기 코일부(105)와 감쇄 코일부(206)에 의해 수신되는 신호의 전압을 나타낸다. 즉,

는 나노입자가 존재하지 않는 경우 0(zero)에 근사한 값으로 결정됨을 확인할 수 있다. here,

denotes a voltage of a signal received by the receiver coil unit 105 and the attenuation coil unit 206 . in other words,

It can be confirmed that is determined as a value close to 0 (zero) when nanoparticles do not exist.

Referring to FIG. 10B , when nanoparticles are present, the voltage induced in the receiver coil unit 105 may be expressed as in Equation 4 below.

는 수신기 코일부(105)에서 유도되는 전압,

는 제2 드라이브 코일부(103)에 의해 유도되는 전압,

는 여기 코일부(104)에 의해 유도되는 전압,

는 나노입자에 의한 신호의 전압을 나타낸다. here,

is the voltage induced in the receiver coil unit 105,

is the voltage induced by the second drive coil unit 103,

is the voltage induced by the excitation coil unit 104,

represents the voltage of the signal by the nanoparticles.

Also, in an embodiment, the voltage induced by the attenuation coil unit 206 may be expressed as in Equation 5 below.

는 감쇄 코일부(206)에 의해 유도되는 전압,

는 제2 드라이브 코일부(203)에 의해 유도되는 전압,

는 여기 코일부(204)에 의해 유도되는 전압을 나타낸다. here,

is the voltage induced by the attenuation coil unit 206,

is the voltage induced by the second drive coil unit 203,

denotes the voltage induced by the excitation coil unit 204 .

In an embodiment, since the receiver coil unit 105 and the attenuation coil unit 206 are connected in series, the voltage of the received signal may be expressed as Equation 6 below.

는 수신기 코일부(105)와 감쇄 코일부(206)에 의해 수신되는 신호의 전압을 나타낸다. 즉,

는 나노입자가 존재하는 경우 나노입자에 의한 신호의 전압(

)에 근사한 값으로 결정됨을 확인할 수 있다. here,

denotes a voltage of a signal received by the receiver coil unit 105 and the attenuation coil unit 206 . in other words,

is the voltage of the signal by the nanoparticles in the presence of nanoparticles (

), it can be confirmed that it is determined as a value close to

Therefore, it can be confirmed that the attenuation method by the attenuator is helpful when nanoparticles are present, and due to the limitations of the analog-to-digital converter (ADC), the signal by the nanoparticles is transmitted to the second drive coil unit 103 and the excitation Since it is too small compared to the signal induced by the coil unit 104, the signal by the nanoparticles cannot be processed, so this attenuation method may be used.

11 is a diagram illustrating an open magnetic particle imaging system 1100 according to an embodiment of the present invention.

Referring to FIG. 11 , the open magnetic particle imaging system 1100 may include an open magnetic particle imaging apparatus 100 , a fixing unit 1101 , a belt unit 1102 , and a motor unit 1103 .

In this case, the fixing unit 110 , the belt unit 1102 , and the motor unit 1103 may be coupled to each other. The belt unit 1102 is coupled to the selection coil unit 101 and the first drive coil unit 102 of the open magnetic particle imaging apparatus 100 and is coupled to the selection coil unit 101 and the first drive unit through the motor unit 1103 . The coil unit 102 may be rotated.

In an embodiment, the open magnetic particle imaging system 1100 may further include a controller (not shown) to control the above-described rotation and operation of the open magnetic particle imaging apparatus 100 .

In one embodiment, the control unit may include at least one processor or microprocessor, or may be a part of the processor. Also, the controller may be referred to as a communication processor (CP). The controller may control the operation of the open magnetic particle imaging apparatus 100 according to various embodiments of the present disclosure.

The above description is merely illustrative of the technical spirit of the present invention, and various changes and modifications may be made by those skilled in the art without departing from the essential characteristics of the present invention.

The various embodiments disclosed herein may be performed out of order, and may be performed simultaneously or separately.

In one embodiment, at least one step may be omitted or added in each figure described herein, may be performed in the reverse order, or may be performed simultaneously.

The embodiments disclosed in the present specification are not intended to limit the technical spirit of the present invention, but to illustrate, and the scope of the present invention is not limited by these embodiments.

The protection scope of the present invention should be interpreted by the claims, and all technical ideas within the scope equivalent thereto should be understood to be included in the scope of the present invention.

100: open magnetic particle imaging device
101: selection coil unit
102: first drive coil unit
103: second drive coil unit
104: excitation coil unit
105: receiver coil unit
106: metal member
111: first lower selection coil
112: second lower selection coil
113: first upper selection coil
114: second upper selection coil
121: first lower drive coil
122: second lower drive coil
123: first upper drive coil
124: second upper drive coil
131: third lower drive coil
132: third upper drive coil
141: first lower excitation coil
142: first upper excitation coil
151: lower receiver coil
152: upper receiver coil
161: lower metal member
162: upper metal member
201: attenuation unit
203: second drive coil unit
204: excitation coil unit
206: attenuation coil unit
231: fourth lower drive coil
232: fourth upper drive coil
241: second lower excitation coil
243: second upper excitation coil
261: lower attenuation coil
262: upper attenuation coil
310: permanent magnet
1100: open magnetic particle imaging system
1101: fixed part
1102: belt part
1103: motor unit

Claims (15)

a selection coil unit for generating FFL (Field Free Line) for nanoparticles in a first direction;
a first drive coil unit generating a magnetic field in a second direction to move the FFL in a third direction;
a second drive coil unit generating a magnetic field in the third direction to move the FFL in a second direction;
an excitation coil unit for oscillating the nanoparticles; and
a receiver coil unit for detecting a signal for the nanoparticles;
containing,
An open magnetic particle imaging device.
According to claim 1,
The selection coil unit and the first drive coil unit rotate in the same direction,
An open magnetic particle imaging device.
According to claim 1,
The selection coil unit includes first and second lower selection coils and first and second upper selection coils positioned on the first and second lower selection coils,
Each of the first and second lower selection coils and the first and second upper selection coils includes a core member,
An open magnetic particle imaging device.
4. The method of claim 3,
The first upper selection coil is disposed parallel to the side surface of the second upper selection coil,
The first lower selection coil is disposed parallel to the side of the second lower selection coil,
An open magnetic particle imaging device.
4. The method of claim 3,
The first drive coil unit includes first and second lower drive coils and first and second upper drive coils positioned on the first and second lower drive coils,
An open magnetic particle imaging device.
6. The method of claim 5,
The first upper drive coil is disposed parallel to a side surface of the second upper drive coil,
The first lower drive coil is disposed parallel to a side surface of the second lower drive coil,
An open magnetic particle imaging device.
6. The method of claim 5,
The second drive coil unit comprises a third lower drive coil and a third upper drive coil positioned on the third lower drive coil,
An open magnetic particle imaging device.
8. The method of claim 7,
The excitation coil unit includes a first lower excitation coil and a first upper excitation coil positioned on the first lower excitation coil,
An open magnetic particle imaging device.
9. The method of claim 8,
The receiver coil unit comprises a lower receiver coil and an upper receiver coil positioned on the lower receiver coil,
An open magnetic particle imaging device.
10. The method of claim 9,
The first and second lower drive coils are positioned on the first and second lower selection coils,
The third lower drive coil is positioned on the first and second lower drive coils,
the first lower excitation coil is positioned on the third lower drive coil;
the lower receiver coil is located on the first lower excitation coil;
An open magnetic particle imaging device.
11. The method of claim 10,
the upper receiver coil is positioned on the lower receiver coil;
the first upper excitation coil is positioned on the upper receiver coil;
the third upper drive coil is positioned on the first upper excitation coil;
The first and second upper drive coils are positioned on the third upper drive coil,
The first and second lower selection coils are positioned on the first and second upper drive coils,
An open magnetic particle imaging device.
12. The method of claim 11,
A Field Of View (FOV) is formed between the lower receiver coil and the upper receiver coil,
Wherein the nanoparticles are located inside the FOV,
An open magnetic particle imaging device.
12. The method of claim 11,
a fourth lower drive coil positioned parallel to the third lower drive coil;
a second lower excitation coil positioned on the fourth lower drive coil and positioned parallel to the first lower excitation coil;
a lower attenuation coil positioned on the second lower excitation coil and parallel to the lower receiver coil;
an upper damping coil positioned on the lower damping coil and positioned parallel to the upper receiver coil;
a second upper excitation coil positioned on the upper attenuation coil and positioned parallel to the first upper excitation coil;
a fourth upper drive coil positioned on the second upper excitation coil and positioned parallel to the third upper drive coil;
Attenuation unit comprising;
further comprising,
A winding direction of the upper receiver coil and the lower receiver coil and a winding direction of the upper attenuation coil and the lower attenuation coil are opposite to each other,
An open magnetic particle imaging device.
14. The method of claim 13,
The attenuation unit attenuates the signal of the receiver coil unit,
An open magnetic particle imaging device.
12. The method of claim 11,
A lower metal member for removing magnetic field interference between the first and second lower selection coils and the first and second lower drive coils, and
an upper metal member for removing magnetic field interference between the first and second upper selection coils and the first and second upper drive coils;
A metal member comprising;
further comprising,
An open magnetic particle imaging device.

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