KR20220040586A - vapor inhalation antiviral composition - Google Patents

Abstract

The present invention is to inhibit and kill viruses and bacteria, and by inhalation spraying an aqueous solution of a composition containing at least one selected from catechin and theaflavin-containing black tea extract, and vitamin C quecetin, fisetin, MSM, chlorhexidine gluconate, and povidone-iodine with vapor, it is possible to inhibit and kill viruses and bacteria infected with the respiratory tract and lungs, thereby being able to contribute to prevent and treat respiratory infections. Steroids are a major therapeutic agent for skin diseases that bind to steroid receptors in cells and generate strong immunomodulatory and anti-inflammatory effects through gene inhibition or activation. Dexamethasone has a glucocorticoid activity 25 to 30 times stronger than that of hydrocortisone and a long duration of action (36 to 72 hours), so it is mainly used for acute and serious diseases.

Description

Antiviral composition inhaled by vapor { vapor inhalation antiviral composition}

The present invention relates to a pharmaceutically effective composition that inactivates and kills viruses and bacteria by inhaling an antiviral and antibacterial composition infected with the respiratory tract as a vapor and spraying it to the respiratory tract and lungs (Metabolism).

Specifically, green tea or black tea extract containing catechin and theaflavin as active ingredients, ascorbic acid, quercetin, dietary sulfur (Methyl-sulfonyl-Methane: MSM), fisetin (Fisetin) Citric acid, chlorhexidine gluconate, povidoneodine, melatonin, and at least one selected from derivatives thereof It relates to a pharmaceutically effective composition that inactivates and kills viruses by inhaling the composition vapor

Viruses that infect the respiratory tract include adenovirus, parainfluenzavirus, respiratory syncytial virus, rhinovirus, and coronavirus.

The size of the virus is generally 30 nm to 100 nm, for example, the SARS-CoV-2 size is known to be about 80 to 100 nm.

Bacteria are prokaryotes with prokaryotic cells. They are the smallest single cells among living things, and they can survive alone because they contain DNA and RNA. Generally, the size is about 1-5㎛.

Viruses that infect the human respiratory tract are highly contagious, and most infections start from the respiratory tract and lungs. The method to suppress and kill viruses and bacteria that infect the respiratory tract is to block the infection, inoculate with antiviral drugs, and take orally drugs. It is unique as a conventional invention for inhibiting and killing these viruses and bacteria, and in Patent Registration No. 10-1796423, in the method for producing an antiviral or antibacterial composition, yellow lotus extract, magnolia bark extract, centella asiatica extract. 10-40 parts by weight of licorice extract , DPG 02 to 10 parts by weight is disclosed, and Patent Registration No. 10-2145634 has antibacterial, antifungal and antiviral activity containing cyclic dipeptide and DL-3-phenyllactic acid for antibacterial, antifungal and antiviral composition. Patent No. 10-1063825 discloses a pharmaceutical composition containing an extract having antiviral activity derived from deciduous mud mushroom as an active ingredient. 0,01 to 03w/v%, 1 to 5w/v% of one or more osmotic taste agents selected from sodium chloride or glycerol, and an aqueous solution containing 00001 to 01w/v% of fragrance for eyes, oral cavity, Disclosed are antiviral and antibacterial compositions for nasal or inhalation use.

1. Patent No. 10-1796423 1. Patent No. 10-2145634 1. Patent No. 10-1063825 1. Patent No. 10-1935250

An object of the present invention is to inactivate and kill viruses and bacteria of the respiratory tract and lungs by inhaling the vapor of an antiviral and antibacterial composition.

Another object of the present invention is to inactivate and kill respiratory and lung viruses by inhaling the vapor of the composition, and to block expansion and cell penetration.

The present invention is to inactivate and kill a virus that infects the respiratory tract in the cell surface layer, inhaling the vapor of a pharmacologically effective composition and spraying it on the respiratory and lung cell surface layers.

Influenza virus that infects the respiratory tract Parainfluenza Virus Adenovirus Rhinovirus Coronavirus RespiratorySyncytialVirus RSV Metapneumovirus Metapneumovirus Metapneumovirus) and, for example, SARS-CoV-2 bind to angiotensin-converting enzyme 2 (ACE2), a surface protein of lung cells, and move into cells in vivo to reproduce and reproduce.

In order for SARS-CoV-2 to penetrate human cells, the site that recognizes ACE2 is a protrusion-shaped spike protein embedded in the ARS-CoV-2 virus envelope. can prevent replication

The detailed description of the antiviral composition of the present invention is as follows.

1) Green tea and black tea extracts and derivatives containing 0.001 to 30 parts by weight of catechin, theaflavin and their derivatives as active ingredients, whose antiviral mechanism of action against SARS-CoV- has been revealed

2) 0.001 to 30 parts by weight of ascorbic acid and derivatives that are converted into dehydroascorbic acid by oxidation and generate hydrogen peroxide (H2O2) and hydroxyl radical (OH-) 3) Strong antiviral mechanism of action 0.001 to 15 parts by weight of quercetin and derivatives 4) Vicetin and derivatives synergistic with quercetin 5) 0.001 to 15 parts by weight of MSM and derivatives synergistic with ascorbic acid 6) citric acid with antiviral action 7) and Derivatives 0.001-15 parts by weight 8) Chlorhexidine gluconate and derivatives that kill viruses and bacteria 0.001-5 parts by weight 9) Iodine and derivatives that kill viruses and bacteria 0.001-5 parts by weight Melatonin 0.001-15 parts by weight And by inhaling the composition vapor of one or more pharmacologically active ingredients selected from derivatives, inactivated and killed by vapor spraying of SARS-CoV-2 in respiratory and pulmonary cells.

The present invention having such an action can be quickly and widely applied to a target without going through metabolism in the human body, such as intravenous injection or oral medication.

SARS-CoV-2 enters cells and self-replicates genetic material (RNA), so SARS-CoV-2, which infects the respiratory tract and moves to the lungs, sprays antiviral vapor before infiltrating the cells to create spikes ( spike) to inactivate and kill the protein, and the present invention will be described in detail below.

Green tea and black tea, the composition of the present invention, are made from the same Camellia Sinensis tea leaves, and can be classified into green tea, oolong tea, black tea, and puer tea according to the process. In general, green tea leaves contain about 75-80% It contains water and 20-25% of polyphenol compounds (flavanols, flavandiols flavonoids, phenolicacids), and most of the polyphenol compounds are catechins.

Green tea is obtained by collecting leaves and steaming or roasting them to stop fermentation. Green tea leaves contain a large amount of catechins. Catechins have excellent antiviral and antibacterial action mechanisms. Among the catechins, epigallocatechin gallate (EGCG) has the strongest antioxidant activity.

EGCG accounts for 7-13% of the dry weight of green tea and has a strong antiviral effect against swine flu virus, seasonal flu virus, and avian influenza.

Oolong tea is fermented about 20% to 65% of green tea, and black tea is fermented more than 85%. During fermentation, catechins are oxidized and theaflavins are produced. Polyphenols catechins are oxidized to quinones, and two quinones are becomes theaflavin

When green tea is fermented for 90 minutes, epigallocatechin gallate is reduced by about 98% or more and is produced as theaflavin.

The antiviral and antibacterial action mechanisms of catechins and theaflavingallate and its derivatives from black tea extract have been known for a long time. Severe acute respiratory syndrome (SARS-CoV) The research results that theaflavin is effective were also presented several times in related academic circles, and it was also published in the world-class medical virology journal (Journal of Medical Virology) on March 10, 2020.

Theaflavin, theaflavin-3 gallate (theaflavin-3-gallate, theaflavin-3'-gallate) theaflavin-3,3' produced from catechins -Digallate (theaflavine-3,3'-digallate) has been reported to have an excellent antiviral effect.

Research results have also been published that the antiviral action of theaflavin is stronger than that of catechin.

Natural antioxidants can protect cells in the human body from damage caused by hydrogen peroxide and the oxidation system, but when trace transition metal ions in tissues exist in free form, they generate hydrogen peroxide (H2O2) and act as a powerful oxidizing agent. used to remove infected cells

The present invention inhales the vapor of green tea or black tea extract containing catechin or theaflavin to the lungs, so the application to the target is dense and wide. And it may be a heating vaporization system, it may be deformed, and it may be a vapor inhalation device in the form of a mask, and it is not limited as long as it is a device capable of inhaling vapor.

The present invention constituted as described above obtains and uses green tea or black tea extract containing 0.001 to 15 parts by weight of the active ingredient of catechin or theaflavin, and 0.1 to 50 parts by weight of green tea or black tea leaves in 100 parts by weight of distilled water, and about 70 to It can be extracted with hot water at 100°C, or an extract can be obtained by selecting at least one of ultrasonic extraction or ethanol extraction, or an aqueous solution can be obtained by including 0.001 to 15 parts by weight of catechin or theaflavin in 100 parts by weight of distilled water, and pharmacology Caffeine contained in black tea extract can be removed if necessary.

For example, there may be a method of adding calcium carbonate to distilled water and black tea leaves, extracting hot water, filtration under reduced pressure, and adding ethylene chloride to remove caffeine, but is not limited thereto. Methods for removing caffeine from green tea or black tea are in this field Since it is a known technique in

Formula 1 below is EGCG contained in green tea and black tea, or a derivative thereof

Formula 2 below is green tea or black tea theaflavin or a derivative thereof

Ascorbic acid, the second composition of the present invention, is a type of water-soluble antioxidant vitamin. Ascorbic acid is a powerful antioxidant that is essential for collagen synthesis and human body. In the human body, glucose transporter molecules are involved in moving vitamin C into cells.

It has been found that when transported, it is converted to the form of oxidized dehydroascorbic acid, and when it enters the cell, it is converted back to ascorbic acid.

Humans need oxygen for survival, and oxygen creates free radicals that are harmful to human tissues during metabolism and can be classified into four types.

1.Superoxide(O2-) 2.Hydroxyl radical(OH-) 3. Hydrogen peroxide(H2O2) 4. Lipid hydroperoxide

Oxygen gains electrons and is reduced to become superoxide. Superoxide is an anion radical of oxygen, a precursor of free radicals. The disproportionation reaction of superoxide produces hydrogen peroxide and hydrogen peroxide generates hydroxyl radicals. Hydrogen peroxide (H2O2) ) is converted into hydroxyl radicals, ascorbic acid contributes to ascorbic acid. Ascorbic acid removes free radicals through its antioxidant action, but also creates them. Hydroxyl radicals are the glycoprotein and Oxidative destruction of spike proteins to inactivation and death

In this process, normal cells are not destroyed by catalase and glutathione peroxidase enzymes decomposing hydrogen peroxide into water. The present invention obtains the pharmacologically active ingredient of ascorbic acid as described above in an aqueous solution, and then vaporizes it with ultrasound and heat to inhale the vapor to the lungs to breathe. and inactivates the virus in the lungs

A composition containing 0.001 to 30 parts by weight of pure ascorbic acid can be obtained based on 100 parts by weight of distilled water, or a composition containing 0.001 to 30 parts by weight of ascorbic acid and its derivatives in 100 parts by weight of green tea and black tea extract can be obtained. In this process, ascorbic acid can be oxidized by reacting with water (H2O).

Formula 3 below refers to ascorbic acid or dihydroascorbic acid and derivatives thereof

The third composition of the present invention, quercetin, is quercetin 4-glucoside, quercetin 4,7-diglycoside, quercetin 3,7-diglycoside (quercetin). 3,7-diglycoside) and quercetin aglycone exist in the form of aglycones such as quercetin diglycosid monoglycoside and quercetin aglycone.

The mechanism of action of quercetin is 1) Inhibits virus cell infection 2) Inhibits replication of infected cells 3) Inhibits resistance of infected cells

According to a study published in Microbial Pathogenesis journal in March 2020, quercetin neutralizes pneumococcal hemolysis and blocks streptococcal pneumonia infection in vitro and in vivo. It has been reported as a substance that causes pneumonia

In a study published in 2016, it was reported that quercetin suppressed a wide range of influenza virus strains including H1N1, H3N2 and H5N1, and had an antiviral action against H1N1 (swine flu) by regulating protein expression

Quercetin is an antioxidant flavonoid present in red wine, apple, plum, red grape, green tea, elderflower and onion.

According to a 2016 Scientific Reports publication, quercetin has been shown to have a therapeutic effect on tumors by interacting with DNA and activating the mitochondrial pathway of natural cell death.

In the present invention, the pharmacologically active ingredient of quercetin is obtained as an aqueous solution, and the vapor is inhaled to the lungs by ultrasonication and heat vaporization to inactivate and kill viruses and bacteria in the respiratory tract and lungs.

It may be a composition containing 0.001 to 15 parts by weight of quercetin in 100 parts by weight of distilled water or an aqueous solution containing green and black tea extracts or ascorbic acid.

The fourth composition of the present invention is fisetin. Fisetin is excellent in antiviral antibacterial, anti-inflammatory, antioxidant and especially in removing senescent cells, so it is used as a cocktail therapy with dasatinib, a leukemia treatment. It is being studied as an anti-aging substance that

Ficetin is a plant flavonoid found in strawberries, mango, cucumber, and fruits and vegetables, and its chemical structure is similar to that of quercetin. It may be a composition containing 0.001 to 15 parts by weight of bicetin in 100 parts by weight of an aqueous solution containing corbic acid or an aqueous solution containing quercetin.

Formula 4 below refers to quercetin, fisetin and derivatives thereof

The fifth composition of the present invention is dietary sulfur (Methyl-sulfonyl-Methane:MSM). MSM is a very simple molecule with 11 atoms of sulfur and methyl groups with the formula (CH3)2SO2, and is organic sulfur. Water and It is one of the basic substances that make up living things, and sulfur is the second most abundant mineral after calcium and phosphorus in the human body.

MSM has a detoxifying effect and increases collagen formation and glutathione production by 80%. It is contained in ginseng, garlic, leek, and green onion, and has an anti-bacterial function. Contains catechin, theaflavin, and black tea extract and ascorbic acid. Activation action is increased when distilled water or green and black tea extracts or aqueous solution containing ascorbic acid or aqueous solution containing quercetin or aqueous solution containing vicetin may be a composition containing 0.001 to 15 parts by weight of MSM

Formula 5 below refers to the dietary sulfur SMS and its derivatives

Citric acid, the sixth composition of the present invention, has strong antiviral and antibacterial properties, and is also called citric acid. It is an organic acid soluble in water and ethanol. One of the carboxylic acids is ionized and acts as a trivalent anion.

If you look at the TCA cycle (Tricarboxylic Acid Cycle), which is the main pathway of mitochondrial metabolism in living cells, citric acid is produced in the process of generating energy (ATP) by ingesting glucose, and it is the main component of citrus fruits in a free state or as a salt. Industrially, citric acid is produced by breeding black mold (aspergillus niger) on sucrose or glucose.

It may be a composition containing 0.001 to 15 parts by weight of citric acid in an aqueous solution containing distilled water or green and black tea extracts or ascorbic acid or an aqueous solution containing quercetin or an aqueous solution containing bicetin or an aqueous solution containing MSM.

The structure of Formula 6 below refers to citric acid and its derivatives

Chlorhexidine gluconate, the 7th composition of the present invention, is a sterilization and disinfectant known to be the safest with strong, broad-spectrum sterilization power. It is used to sterilize hands and skin, or as a sterilization and preservative for cosmetics and various drugs. It is used as a gargle solution for

Chlorhexidine gluconate is dissociated at physiological pH to release positively charged chlorhexidine cations, and cation molecules bind to negatively charged virus and bacterial cell walls to sterilize. Directly disinfects and kills viruses and bacteria in the respiratory tract and lungs

It may be a composition containing 0.001 to 5 parts by weight of chlorhexidine gluconate in distilled water or green and black tea extracts, or an aqueous solution containing ascorbic acid, or an aqueous solution containing quercetin, an aqueous solution containing bicetin, or an aqueous solution containing MSM.

Formula 7 below refers to chlorhexidine gluconate and derivatives thereof

Povidone-iodine, composition 8 of the present invention, is a chemical compound that combines polyvinylpyrrolidone and iodine and has a disinfecting effect on a wide range of pathogens such as viruses, bacteria, fungi, and protists such as amoeba. It oxidizes and destroys the constituent proteins of Gram-positive and negative, and kills all pathogens such as viruses, bacteria, and fungi. Excellent antiviral effect of 99% in

Distilled water or green tea, black tea extract or aqueous solution containing ascorbic acid, aqueous solution containing quercetin, aqueous solution containing vicetin, aqueous solution containing MSM, or aqueous solution containing chlorhexidine gluconate contains 0.001 to 5 parts by weight of iodine can be a composition

Formula 8 below refers to povidone iodine and its derivatives

Melatonin, the ninth composition of the present invention, is water-soluble and easily decomposed and oxidized when exposed to infrared and ultraviolet rays, and its pharmaceutical components are reduced. Melatonin is a hormone secreted from the pineal gland in the upper part of the cerebellum. It has a structure in which a methoxy group is substituted for a benzene ring. Melatonin has an excellent ability to remove free radicals, so it has been found to have anti-cancer effects, strengthen the immune function of the human body, and have anti-aging effects. Melatonin is a powerful antiviral antibacterial antioxidant it works

Melatonin has a stronger antioxidant action than glutathione vitamin C and vitamin E. Conventional vitamins do not easily enter cells or organelles, but melatonin freely moves all parts of the cell, protecting DNA from free radicals, repairing damaged DNA, Inhibits skin aging The effective pharmacological action of melatonin has been confirmed by numerous studies.

Distilled water or an aqueous solution containing green or black tea extract or ascorbic acid, or an aqueous solution containing quercetin, an aqueous solution containing bicetin, an aqueous solution containing MSM, or an aqueous solution containing chlorhexidine gluconate or an aqueous solution containing povidone iodine ㅁ May be a composition containing 0.001 to 15 parts by weight of memelatonin

As described above, the present invention provides green tea, black tea extract containing catetin and theaflavin as active ingredients and/or distilled water selected from ascorbic acid, quercetin, fisetin, MSM, chlorhexidine gluconate, povidone iodine, melatonin and derivatives thereof. It may be a composition containing one or more

For example, 0.001 to 30 parts by weight of ascorbic acid may be further included in green tea and black tea extract containing 0.001 to 30 parts by weight of catechin theaflavin as an active ingredient, 0.001 to 15 parts by weight of quercetin may be further included, and 0.001 to 15 parts by weight of vicetin Additional parts may be further included, MSM may further include 0.001-15 parts by weight, chlorhexidine gluconate may further include 0.001-5 parts by weight, povidone iodine 0.001-5 parts by weight, and melatonin 0.001-15 parts by weight may be further included. It may be a composition containing at least one type, and may be a composition containing catechin or theaflavin in distilled water.

In the present invention, the method of pulmonary breathing of the vapor of the composition is, for example, inhaling the vapor by targeting the corona 19 virus infected in the throat, mouth, nose, airways and lungs.

Because it is ultrasonic and heat-vaporized steam, the distribution is dense and extensive, so the pharmacologically active ingredient can reach the pulmonary vesicles and can be quickly applied directly to the target.

In the present invention, the steam generation of the composition may be various methods. For example, it may be a heating vaporization method, an ultrasonic method, and may be a method of applying one or more methods, and may be a method of applying one or more methods, but is not limited thereto. can be a way

On the other hand, if the vapor of the present invention composition is sprayed on the skin and indoors, viruses and bacteria can be inhibited and killed can do

The present invention directly destroys viruses that infect the respiratory tract and lungs by inhaling the vapor of a pharmaceutically effective composition of antiviral and antibacterial action into the lungs, so it can be inactivated and killed quickly.

The present invention will be described in more detail with reference to the following examples. These examples are only for illustrating the present invention in more detail, and the scope of the present invention is not limited by these examples.

Example 1

1. Pure black tea leaves containing catechin theaflavin in 1000 g of distilled water were extracted with hot water at 70 to 100 degrees for 1 to 48 hours and filtered under pressure to obtain a black tea extract containing 0.001 to 30 parts by weight of catechin theaflavin.

Example 2

1000 g of distilled water contained 0.001 parts by weight to 30 parts by weight of ascorbic acid, maintained a temperature of 1 to 25 degrees, blocked light, and stirred at 5 to 30 rpm for 30 to 120 minutes. Ascorbic acid was dissolved and the composition was refrigerated.

Example 3

1000g of distilled water contains 0.001 parts by weight to 15 parts by weight of querserin, maintains a temperature of 1 to 25 degrees, blocks light, and stirs at 5 to 30 rpm for 30 to 120 minutes. Querserin was dissolved and the composition was refrigerated.

Example 4

0.001 to 15 parts by weight of fisetin was contained in 1000 g of distilled water, kept at a temperature of 1 to 25 degrees, blocked from light, and stirred at 5 to 30 rpm for 30 to 120 minutes. The fisetin was dissolved and the composition was refrigerated.

Example 5

0.001 to 15 parts by weight of MSM was contained in 1000 g of distilled water, kept at a temperature of 1 to 25 degrees, blocked from light, and stirred at 5 to 30 rpm for 30 to 120 minutes. MSM was dissolved and the composition was refrigerated.

Example 6

In 1000 g of distilled water, 0.001 parts by weight to 5 parts by weight of chlorhexidine gluconate was contained, the temperature was maintained at 1 to 25 degrees, light was blocked, and the mixture was stirred at 5 to 30 rpm for 30 to 120 minutes. The composition was refrigerated.

Example 7

0.001 parts by weight to 5 parts by weight of povidone iodine were contained in 1000 g of distilled water, the temperature was maintained at 1 to 25 degrees, light was blocked, and the mixture was stirred at 5 to 30 rpm for 30 to 120 minutes. The composition was refrigerated.

Example 8

Same as Examples 2 to 7, except that distilled water was replaced with black tea extract, and the composition was refrigerated.

Example 9

Same as Example 1, except that 0.001 parts by weight to 15 parts by weight of at least one selected from ascorbic acid, quercetin, xicetin, MSM, chlorhexidine gluconate, povidone-iodine, and melatonin

Example 10

Same as Example 2, except that it contained 0.001 parts by weight to 15 parts by weight of at least one selected from xetine, theaflavin, theaflavingalate, quercetin, xietin, MSM chlorhexidine gluconate, povidone-iodine, and melatonin.

implementation 11

50 ml of the composition obtained in the same manner as in Examples 1 to 10 was filled in the liquid container of a vapor generating device similar to a general electronic cigarette, and the vaporization part was heated with power applied from the battery to vaporize the composition in the liquid container and lung respiration was inhaled.

12 in practice

The composition obtained in the same manner as in Example 11 was vaporized by ultrasound and inhaled by pulmonary respiration.

12 in practice

200ml of the compositions of Examples 1 to 10 were filled in an ultrasonic wave and heat vaporization humidifier, and UV-C (ultraviolet rays) was irradiated to the composition and sprayed indoors.

Claims (14)

A pharmaceutical composition that kills viruses and bacteria by inhaling the steam of an aqueous solution of green tea, black tea and extract containing 0.001 to 30 parts by weight of catechin, fetal flavin and its derivatives as active ingredients A pharmaceutical composition that kills viruses and bacteria by inhaling the vapor of an aqueous solution containing 0.001 to 30 parts by weight of catechin, fetaflavin and its derivatives as active ingredients in distilled water A pharmaceutical composition that kills viruses and bacteria by inhaling the vapor of an aqueous solution containing 0.001 to 30 parts by weight of ascorbic acid and dihydroascorbic acid derivatives thereof as an active ingredient in distilled water [Claim 3] The pharmaceutical composition for killing viruses and bacteria by inhaling the vapor of an aqueous solution according to claim 1, wherein 0.001 to 30 parts by weight of ascorbic acid and dihydroascorbic acid derivatives thereof are included. [Claim 5] The pharmaceutical composition for killing viruses and bacteria by inhaling the vapor of an aqueous solution according to claim 1 to 4, further comprising 0.001 to 15 parts by weight of querserine and its derivatives. [Claim 6] The pharmaceutical composition for killing viruses and bacteria by inhaling the vapor of an aqueous solution according to claim 1 to 5, further comprising 0.001 to 15 parts by weight of vicetin and its derivatives. [Claim 7] The pharmaceutical composition for killing viruses and bacteria by inhaling the vapor of an aqueous solution according to any one of claims 1 to 6, further comprising 0.001 to 15 parts by weight of MSM and its derivatives. [Claim 8] The pharmaceutical composition according to claim 1 to 7, wherein the chlorhexidine gluconate and its derivatives are contained in an amount of 0.001 to 5 parts by weight of an aqueous solution vapor inhaling to kill viruses and bacteria. [Claim 9] The pharmaceutical composition for killing viruses and bacteria by inhaling the vapor of an aqueous solution according to any one of claims 1 to 8, further comprising 0.001 to 5 parts by weight of povidone-iodine and its derivatives. [Claim 5] The method of claim 1 to 4, wherein at least one selected from quercetin, vicetin, theaflavin, theaflavingalate, quercetin, xetine, MSM, chlorhexidine gluconate, povidone-iodine, and melatonin is 0.001 parts by weight to 15 parts by weight. Pharmaceutical composition for killing viruses and bacteria by inhaling the vapor of an aqueous solution characterized in that it contains An aqueous solution comprising 0.001 to 15 parts by weight of at least one selected from among quercetin, vicetin, theaflavin, theaflavingalate, quercetin, xixetine, MSM, chlorhexidine gluconate, povidone iodine, and melatonin in distilled water Pharmaceutical composition that kills viruses and bacteria by inhaling vapors The method for killing viruses and bacteria by spraying an aqueous solution vapor, characterized in that the composition is sprayed indoors in the same manner according to claim 1 to 11 The method of claim 12, wherein the composition is irradiated with UV (ultraviolet rays) to generate free radicals. [Claim 14] The method of claim 1 to 13, wherein the steam generation is at least one of ultrasonic waves and heat vaporization method.