KR20220021748A - Suture forming a three-dimensional protrusion and process for manufacturing the same - Google Patents

Abstract

The present invention provides a method for manufacturing a suture in which three-dimensional protrusions are formed. According to embodiments of the present invention, the manufacturing method comprises: a step for rotating a suture preform having an elastic force, and forming three-dimensional micro cogs on the surface of the suture preform through a forming mold; and a step for applying a tensile force and a rotational force to the suture preform on which micro cogs have been formed, by deforming the spatial position of the forming mold, at a temperature between equal to or higher than the glass transition temperature and equal to or lower than the melting point of the main component contained in the suture preform, so as to produce a suture having a three-dimensional structure.

Description

Suture forming a three-dimensional protrusion and manufacturing method thereof

The present invention relates to a suture and a method for manufacturing the same, and more particularly, to a suture for forming a three-dimensional protrusion and a method for manufacturing the same.

The content described in this section merely provides background information for the present embodiment and does not constitute the prior art.

In suturing surgery and plastic surgery, when using a general suture to suture, the effect of the plastic surgery is halved, and the skin tissue cannot be fixed or held, so there is a problem in that the finishing of the hall after surgery is not good. Accordingly, in place of the surgical suture that has been conventionally used in conventional suture surgery, especially in wrinkle removal plastic surgery, the suture itself not only fixes and maintains the skin tissue, Many techniques for sutures that can easily remove wrinkles by pulling them have been proposed.

A barbed suture is formed by forming one or more barbed projections at regular intervals along the surface of the suture. When the suture is inserted in one direction and tension is applied in the opposite direction, the barbs located on the surface of the suture are firmly adhered to the tissue and are separated from the normal suture. It was used as a suture that did not need to be knotted otherwise.

In order to form and shape the protrusion on the outer circumferential surface of the suture, the structure and operation of the manufacturing device must be very precise and minute. That is, the surgical suture has a very thin thickness, unlike a general thread, and therefore, in order to form fine barb projections with a uniform height and thickness in such a thin suture, the molding operation must be performed very precisely, and the There is a problem in that it is formed in two dimensions and affects the traction force.

Embodiments of the present invention have been devised to solve the above problems, and by applying a rotational force to the suture body, a three-dimensional three-dimensional surface of a 360° tornado structure is implemented to enhance the lifting effect and strengthen the tensile force. There is a purpose.

Other objects not specified in the present invention may be additionally considered within the scope that can be easily inferred from the following detailed description and effects thereof.

According to one aspect of this embodiment, in the present invention, in a method for manufacturing a suture by a suture manufacturing apparatus, a suture body having elastic force is rotated and processed, and three-dimensional microprotrusions are formed on the surface of the suture body through a molding mold. In the step of forming (Micro Cog) and above the glass transition temperature below the melting point of the main component included in the whole body of the suture, by changing the spatial position of the molding mold or rotating the whole body of the suture, the microprotrusions are We propose a suture manufacturing method comprising the step of manufacturing a suture having a three-dimensional structure by applying a tensile force and a rotational force to the formed suture body.

According to another embodiment of the present invention, the present invention is a suture body formed in a linear structure having an elastic force; and micro-cogs formed on the outer surface of the suture body, wherein the micro-protrusions are formed at regular intervals throughout the suture body in a three-dimensional three-dimensional structure. sutures are suggested.

According to another embodiment of the present invention, the present invention provides a supply unit for supplying a suture body having elastic force, a discharge unit for discharging a suture body with three-dimensional microprotrusions formed on the surface of the suture body body, and the supply unit Protrusion molding for producing a suture having a three-dimensional structure by applying tensile and rotational force to the suture body in which the microprotrusions are formed by changing the spatial position of the molding mold by fixing the suture body and fixing the suture body A suture manufacturing apparatus including the apparatus is proposed.

As described above, according to the embodiments of the present invention, the present invention has excellent tensile strength and high traction force through the suture forming the protrusion of a three-dimensional structure.

also. According to the embodiments of the present invention, the present invention has an effect of maintaining the shape of the protrusion for a long time by implementing a protruding external structure (protrusion) through a molding method.

Even if it is an effect not explicitly mentioned herein, the effects described in the following specification expected by the technical features of the present invention and their potential effects are treated as if they were described in the specification of the present invention.

1 and 2 are flowcharts schematically illustrating a method of manufacturing a suture for forming a three-dimensional protrusion according to an embodiment of the present invention.
3 to 6 are exemplary views for manufacturing a suture forming a three-dimensional protrusion according to an embodiment of the present invention.
7 and 8 are exemplary views showing a suture forming a three-dimensional protrusion according to an embodiment of the present invention.
9 is an exemplary view illustrating the shape of a suture forming a three-dimensional protrusion after time has elapsed according to an embodiment of the present invention.
10 is a view comparing the suture forming the three-dimensional protrusion and the suture forming the cut protrusion according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. Advantages and features of the present invention, and a method for achieving them will become apparent with reference to the embodiments described below in detail in conjunction with the accompanying drawings. However, the present invention is not limited to the embodiments published below, but may be implemented in various different forms, and only these embodiments allow the publication of the present invention to be complete, and common knowledge in the technical field to which the present invention pertains It is provided to fully inform the possessor of the scope of the invention, and the present invention is only defined by the scope of the claims. Like reference numerals refer to like elements throughout.

Unless otherwise defined, all terms (including technical and scientific terms) used herein may be used with the meaning commonly understood by those of ordinary skill in the art to which the present invention belongs. In addition, terms defined in a commonly used dictionary are not to be interpreted ideally or excessively unless clearly defined in particular.

The terms used in this application are only used to describe specific embodiments, and are not intended to limit the present invention. The singular expression includes the plural expression unless the context clearly dictates otherwise. In the present application, terms such as “comprise” or “have” are intended to designate that a feature, number, step, operation, component, part, or combination thereof described in the specification exists, but one or more other features It should be understood that this does not preclude the existence or addition of numbers, steps, operations, components, parts, or combinations thereof.

Terms including an ordinal number such as second, first, etc. may be used to describe various elements, but the elements are not limited by the terms. The above terms are used only for the purpose of distinguishing one component from another. For example, without departing from the scope of the present invention, the second component may be referred to as the first component, and similarly, the first component may also be referred to as the second component. and/or includes a combination of a plurality of related listed items or any of a plurality of related listed items.

The present invention relates to a suture for forming a three-dimensional protrusion and a method for manufacturing the same.

The fascia of a person's face is a slippery membrane composed of connective tissues and muscles beneath the skin and fat, and consists of several layers, not one. In addition, the fascia can play a role in creating facial expressions by transferring muscle movements to the skin, and is the layer where most of the procedures are performed in thread lifting. The support ligament is a tissue that holds the soft tissues from sagging due to aging of the skin. At this time, the sagging phenomenon is conspicuous, and it can be used as a fixing point or a lifting point during the thread lifting procedure. When the skin is aging and the fat layer comes down, a thread lifting procedure can be performed. For the thread lifting procedure, a thread with a protrusion is used, and the protrusion of the thread inserted into the skin is caught in the tissue such as retaining ligament or fibrous compound and the fascia (SMAS, Superficial Muscular Aponeurotic System) A method of physically pulling the layer can be used.

A suture is a thread used for suturing tissue damage caused by surgery or trauma, or for plastic surgery, and may serve to support the tissue. Sutures include non-absorbable sutures and absorbable sutures. In particular, the thickness of the suture does not affect the absorption rate, but the thin suture heals faster and the tissue response is less than the thick suture because of the tissue reaction or tissue stimulation.

The suture 10 forming a three-dimensional protrusion is two-dimensionally in a state in which the thread is twisted using a suture fixing part (for example, a tool for holding and fixing a thread such as a pin vise) indicating an accessory holding the suture body. If the shape is taken and unwrapped, a three-dimensional protrusion shape can be realized, or a three-dimensional protrusion shape can be realized by forming a two-dimensional protrusion and rotating the yarn, and then curing it at a certain temperature. In addition, the suture 10 forming the three-dimensional protrusion may implement a three-dimensional protrusion while the forming mold only moves up and down, and the three-dimensional protrusion may be implemented while the thread is rotated, or the forming mold itself rotates.

1 and 2 are flowcharts schematically illustrating a method of manufacturing a suture for forming a three-dimensional protrusion according to an embodiment of the present invention.

The suture manufacturing method for forming a three-dimensional protrusion includes the steps of rotating the suture body having elastic force, and forming three-dimensional micro cogs on the surface of the suture body through a molding mold (S100) and before the suture. Manufacturing a suture having a three-dimensional structure by applying tensile and rotational forces to the entire body of the suture in which microprotrusions are formed by deforming the spatial position of the molding mold under the conditions of the glass transition temperature or lower below the melting point of the main component included in the body (S200) is included.

The step of rotating the suture body having elastic force and forming three-dimensional micro-cogs on the surface of the suture body through a molding mold (S100) is to attach both ends of the suture body to the suture fixing part, respectively. It is connected and rotated to rotate the suture, and the rotated suture body can be processed to manufacture the suture body with the three-dimensional microprotrusions formed therein.

The step (S100) of rotating the suture body having elastic force and forming three-dimensional micro protrusions (Micro Cog) on the surface of the suture body through a molding mold (S100) includes the suture whole body at both ends of each suture fixing part. When this is fixed and rotates a preset number of times, and forms microprotrusions on the rotated suture body or loosens the rotated suture after curing, the number of rotations may be reduced by 0% to 30%.

Specifically, if the shape of the suture is taken while the whole body of the suture is rotated, or the thread is unscrewed after curing, a difference in the number of rotations may occur. The difference in the number of rotations may vary depending on the length of the molding mold taking the shape, and the number of rotations may be reduced by about 0% to 30%. For example, if the whole body of a suture is rotated 10 times and the rotation is released after forming or processing the shape, it may be rotated about 7 to 10 times. This is a shape that occurs when the shape of the microprotrusion is taken or processed while the whole body of the suture is rotated.

The step (S100) of rotating the suture body having elastic force, and forming three-dimensional micro-cogs on the surface of the suture body through a molding mold (S100) to produce a suture body forming a three-dimensional protrusion The first protrusion manufacturing step (S122) of manufacturing the whole body of the suture with microprotrusions formed using a roll mill or a compression press through the step (S110) of selecting a method for using an overflow mold A second protrusion manufacturing step (S124) of manufacturing a suture body with microprotrusions formed therein, and a third step of manufacturing a suture body with microprotrusions formed by rotational processing using a molding mold that forms the shape of the suture body and microprotrusions It can be performed by selecting one of the protrusion manufacturing steps (S126).

In the first protrusion manufacturing step (S122) of manufacturing the suture body with fine protrusions using a roll mill or a compression press, the rotated suture body is pressed using a roll mill, and the suture is passed through a molding mold. The whole body can be manufactured.

The second protrusion manufacturing step (S124) of manufacturing the suture whole body with fine protrusions using an overflow mold is a temperature condition and a certain range below the melting point to above the glass transition temperature by melting the suture whole body rotated in the flow mold. The suture body can be manufactured by heat-pressing solid-phase forming method under the pressure condition of

The third protrusion manufacturing step (S126) of manufacturing the suture body by rotational processing using a molding mold that forms the shape of the suture and microprotrusions rotates the suture body connected to both ends of the suture fixing part, and moves the molding mold up and down The first processing step of compressing the suture by rotating the suture body connected to both ends of the suture fixing part, and the second processing step of compressing the suture body by rotating and up and down the molding mold itself using at least one cylinder You can do this by choosing one of them.

The second processing step of rotating the suture body connected to both ends of the suture fixing part and compressing the suture body by rotating the molding mold itself using at least one cylinder and moving up and down is constant by placing the cylinder in an oblique line on the suture. The forming mold is rotated by forming atmospheric pressure, and the forming mold can be rotated by 40° to 70° using a cylinder arranged in an oblique line.

In the second processing step, when the mold is rotated clockwise or counterclockwise using a cylinder, it may be rotated within 360° and then rotated in the opposite direction to the rotational direction to return to its original state, which may or may not be the case.

The step (S100) of rotating the suture body having elastic force and forming three-dimensional micro-protrusions (Micro Cog) on the surface of the suture body through a molding mold (S100) is the suture body rotates at the moment the molding mold moves. And, the rotation of the suture body can be stopped at the moment when the molding mold compresses the suture body.

According to an embodiment of the present invention, the suture body is a material used to prepare a suture that forms a three-dimensional protrusion, and can form the suture body 12, and can be implemented as the suture body 12, It is not necessarily limited to this.

According to an embodiment of the present invention, the suture body is an ester-based biodegradable polymer such as PGA, PLLA, PCL, PDO, PLGA, PHA, etc., with a total length of 40 to 430 mm and a thickness of 0.3 mm. may be formed, but is not necessarily limited thereto.

According to an embodiment of the present invention, the microprotrusions may be formed to have a length of 1.0 to 3.0 mm and a height of 0.2 to 0.4 mm, but is not necessarily limited thereto.

According to an embodiment of the present invention, the molding mold for forming the microprotrusions is a mold material such as SK11, and may be formed of Sk61, sk11, kp4, s45c, etc., but is not necessarily limited thereto.

In Figures 1 and 2, although it is interposed as sequentially executing each process, this is merely illustrative, and those skilled in the art are shown in Figures 1 and 2 within the range not departing from the essential characteristics of the embodiment of the present invention. Various modifications and variations may be applied by changing the described order, executing one or more processes in parallel, or adding other processes.

3 to 6 are exemplary views for manufacturing a suture forming a three-dimensional protrusion according to an embodiment of the present invention.

According to an embodiment of the present invention, in an overflow mold (overflow mould), heat-press under a temperature condition below the melting point of the main component contained in the suture to a temperature condition above the glass transition temperature and a pressure condition in the range of 10 to 200kgf/cm2 ) It is possible to manufacture a suture preform in which micro cogs are formed on the surface of the suture by solid-phase forming method. Here, the pressure condition is not limited to 10-200 kgf/cm 2 .

The suture 10 for forming a three-dimensional protrusion is one in which microprotrusions are formed without forming a cut angle on the surface of the suture, and a rotation of 30° to 360° is added per cm of the length of the suture, and the microprotrusions have directivity. and may have anchoring ability in the opposite direction of insertion when inserted into soft tissue.

The preparation of the suture body is based on the molecular arrangement and thermal properties of the main component included in the suture. The suture 10 forming the three-dimensional protrusion has a directional molecular orientation therein, so that it maintains high tensile strength of the suture 10 forming the three-dimensional protrusion. However, when the suture 10 forming the three-dimensional protrusion is heated in the range from the melting point to 30 ° C below the melting point (Tm to Tm-30 ° C), the ductility increases but shrinkage deformation occurs and the molecular arrangement is lost, The tensile strength required for tissue sealing is lost.

Even if the suture 10 forming the three-dimensional protrusion is in the heating section, when both ends are fixed to prevent shrinkage and deformation and then heat in the same range is applied, the ductility of the polymer suture increases while the tensile strength is maintained like the yarn of the polymer suture. have

The suture 10 forming the three-dimensional protrusion uses the above characteristics of the polymer suture, and increases the ductility by heating the yarn to a specific temperature below the melting point of the main component contained in the suture, but by fixing both ends to suppress the shrinkage deformation. In the case of forming a protrusion on the surface by compression molding in one state, there is a feature that microprotrusions can be formed on the surface of the yarn while maintaining the molecular orientation of the polymer suture.

According to an embodiment of the present invention, an overflow mold may be used to manufacture the suture body. The outflow mold is composed of a molding space and an outflow space, and it is preferable that the molding space and the outflow space be separated by a partition wall not exceeding 60 μm. Preferably, the distance between the molding space and the outlet space of the outlet mold is in the range of 30 μm to 60 μm. If the distance between the molding space and the outflow space exceeds 60 μm, there is a problem in that the separation of the product from the burr after press molding is not performed well. Separation of the product from the burr may be difficult.

According to an embodiment of the present invention, when the molding mold is used to manufacture the suture whole body, the flattened suture whole body may be cut and molded. Here, the molding mold is provided in the longitudinal direction of the suture body to form a protrusion by cutting some of both ends of the flattened suture body in a press manner.

Specifically, the protrusion formation using the molding mold can be flattened after the suture whole body is pressed by supplying the suture whole body of a certain length through the supply part in a state in which the suture whole body is wound. In the protrusion formation using the molding mold, when the upper mold lowers the suture whole body, the protrusion forming stripper contacts the lower mold, and the barb-shaped stripper fixes the suture body in the seating groove, and at this time, the upper mold continues to descend and the first, The second punch is further lowered to form a flattened suture whole body through press molding for the suture body, and cutting is performed while passing a part of one or both sides of the flattened suture body through the blade head of the second punch. made, press molding of the microprotrusions is made. At this time, the cutting scrap cut from the wire by the blade head unit 32 is discharged to the discharge unit, and the cutting scrap sucked through the suction means may be discharged to the outside of the press working unit PU and then collected. At this time, even if a burr is generated on the cut surface of the suture body and the microprotrusion due to contact during the elevating and lowering of the punch, the burr is adsorbed by a negative pressure and discharged through the discharge unit and then collected. Through the press-cutting molding of the above-described process, a plurality of fine protrusions in the longitudinal direction of the whole body of the suture can be created with the same standard, and the effect of reducing the manufacturing cost and improving productivity can be provided.

Further, according to an embodiment of the present invention, the introduction portion of the outlet space is 45° to 90°, preferably 80°. If the outflow space inlet is less than 45°, high pressure is required for press molding and the separation of the burr from the product tends to be difficult after molding. The depth of the outlet space should be formed so as not to exceed the depth of the molding space, and is preferably in the range of 50 μm to 100 μm. Preferably, it can be formed to be 100 μm to facilitate separation of the product and the burr.

The width of the outlet space is formed along the boundary line of the molding space and ranges from 250 µm to 500 µm, preferably 500 µm. When the width of the outlet space exceeds the above range, there is a problem in that the pressure applied to the outlet mold is increased to weaken the durability of the molded part.

The size of the outlet space mentioned above enables the removal of burrs that appear on the surface after thermocompression molding of the suture 10 forming a three-dimensional protrusion, Since it is not easily removed from the molded product, it cannot be processed into a medical suture.

The temperature at the time of outflow molding is a specific temperature within the temperature conditions from below the melting point of the main component included in the suture to above the glass transition temperature, and preferably from 15°C (Tm-15°C) below the melting point to 30°C below the melting point (Tm- 30°C). At this time, when the applied temperature is room temperature, the compression-expansion phenomenon occurs during compression molding due to the elasticity of the polymer suture. However, when the compressive force is removed, a certain part of the restoration and expansion is made, and the burr part between the molds is contracted, which may mean that the shape of the product is formed differently from the molding space. In order to overcome this, the heating-compression temperature was adjusted to a specific temperature within the temperature conditions from below the melting point of the main component contained in the suture to above the glass transition temperature.

The size of the pressure applied to the outlet mold is in the range of 10 to 200 kgf/cm 2 , preferably 80 to 160 kgf/cm 2 , and it is suitable to use a size in the range of 15 to 50 tons for the press. If the pressure is less than the above range, it tends to be difficult to process into a medical suture because the burr is not removed by the outflow mold. can cause

The whole body of the suture, which is the primary molded foam processed by heat-compression molding in the step that satisfies all of the above conditions, can form micro cogs on the surface while maintaining the strength of the polymer suture at 80 to 90%. And, the microprotrusions may be formed in a three-dimensional shape.

In this step, tensile force is applied to the whole body of the suture molded by heat compression with both ends fixed, and heat-treated for a certain period of time to manufacture a suture, a secondary molded foam. At this time, the magnitude of the tensile force is 10% to 30% of the maximum tensile strength of the whole body of the suture, and preferably 20%. The time for applying the heat may be formed in the range of 2 hours or more.

By applying a twist to the medical suture by applying a rotational force at the same time as a tensile force, the position of the microprotrusions can be made in a multi-directional spiral direction. It has a maximum angle of rotation of both ends of 360°/cm or less. The temperature of the heat applied in this step is above the glass transition temperature (Tg) of the main component included in the suture used to prepare the whole body of the suture and below the melting point (Tm), and preferably below the melting point 15 °C (Tm-15). ℃) below the melting point 30 ℃ (Tm-30 ℃) range.

A thorn with directionality, which is an ideal protrusion shape, is formed, and due to the nature of heat-compressing the suture yarn to form protrusions, the positions of protrusions are staggered. The size of the microprotrusion located on the surface of the medical suture is determined in proportion to the size of the suture yarn. The height of the protrusion is proportional to the size of the suture yarn, but it is preferable not to exceed the diameter size of the suture yarn in view of the moldability of the product.

Figure 3 is an exemplary view showing a pin vise for fixing the suture body in order to manufacture a suture forming a three-dimensional protrusion according to an embodiment of the present invention. Figure 3 (a) is a view showing the shape of the pin vise for fixing the suture, Figure 3 (b) is a cross-sectional view of the pin vise for fixing the suture.

The suture fixing part 20 may be implemented as a pin vise, but is not necessarily limited thereto, and may be implemented as a tool for holding the suture body.

According to an embodiment of the present invention, the pin vise 20 for fixing the whole body of the suture may be implemented as a device serving to fix the whole body of the suture.

The pin vise 20 may include a fixing part 22 and a screw wire 24 .

The fixing part 22 can move up or down along the screw line 24 to fix a part of the suture body 12, and can be rotated by 360°.

The left side of Fig. 3 (a) shows the shape of the fixing part 22 for connecting the suture body 12 before fixing the suture body 12, and the right side of Fig. 3 (a) is the suture body ( The shape of the fixing part 22 fixed by connecting 12) is shown.

4 is an exemplary view illustrating an apparatus for manufacturing a suture after fixing the suture body through a pin vise according to an embodiment of the present invention.

Figure 4a (a) is a block diagram showing a suture manufacturing apparatus according to an embodiment of the present invention, Figure 4a (b) is a process process of the protrusion molding apparatus of the suture manufacturing apparatus according to an embodiment of the present invention It is an example diagram to illustrate. Figure 4b is an exemplary view showing a protrusion molding apparatus of the suture manufacturing apparatus according to an embodiment of the present invention.

Referring to FIG. 4A , the suture manufacturing apparatus 60 includes a supply unit 62 , a discharge unit 66 , and a protrusion forming apparatus 64 . 4B is a diagram illustrating the projection molding apparatus 64, and the shape of the projection molding apparatus 64 is not necessarily limited thereto.

The protrusion molding apparatus 64 may include a jig 30 , a support part 32 , a lower plate 34 , a suture fixing part 20 , and a molding mold 40 . Here, the protrusion molding apparatus 64 may rotate the suture body by fixing the suture body to the jig 30 through the suture fixing part 20 .

The suture fixing unit 20 may be implemented as a tool for holding the suture body. For example, the suture fixing unit 20 may be implemented in such a way that the whole body of the suture is held together like a configuration in which the whole body of the suture is fixed by passing through grooves at opposite ends like a wire meat plate. The suture fixing part 20 is implemented and described as a pin vise representing an embodiment of the present invention, but is not necessarily limited thereto.

The protrusion forming apparatus 64 may maintain twisting (rotation) in a temperature condition above the glass transition temperature, and may be cured using an oven after fixing the yarn using the jig 30 .

Curing may be performed at a temperature above the glass transition temperature (Tg) and below the melting point (Tm) as a post-processing after processing the yarn. At this time, all of the polyester-based sutures are rotatable. This uses the crystalline and amorphous structures of all polymer characteristics, and the glass transition temperature (Tg) represents the temperature at which the amorphous moves.

According to an embodiment of the present invention, if a movement is applied at a temperature above the glass transition temperature (Tg) to give orientation, the main surface may be re-oriented and fixed. The orientation indicates that the orientation of bonds and dipoles constituting a substance, molecules and polymer chains, or microcrystals, etc. are shifted in a specific direction.

The suture manufacturing apparatus 60 may include a supply unit 62 for supplying the suture body and a discharge unit 66 for discharging the suture body in which the fine protrusions 14 are formed. At this time, the supply unit 62 and the discharge unit 66 may be supplied with the whole body of the suture by a transfer means for transporting the whole body of the suture in the longitudinal direction, and the whole body of the suture having the fine protrusions 14 may be discharged.

Here, the supply part 62 and the discharge part 66 are connected to the projection forming apparatus 64 .

The suture 10 forming the three-dimensional protrusion may be cut to a predetermined length by the discharge unit 66 when the three-dimensional microprotrusion 14 is formed.

At least two pin vise 20 may be formed in pairs to fix both ends of the suture body.

The jig 30 may support a plurality of pin vices 20 respectively provided at both ends of the suture body in a state of being fixed to the plate.

The forming mold 40 may be spatially deformed to form three-dimensional microprotrusions 14 on the surface of the suture body fixed to the pin vise 20 .

The protrusion forming apparatus 64 may further include a cylinder connected to the forming mold 40 to rotate the forming mold 40 . The cylinder 50 rotates the molding mold 40 clockwise or counterclockwise, and after the molding mold 40 rotates within 360°, it can be rotated in the opposite direction to the rotational direction to return to the original state.

The molding mold 40 is installed at regular intervals in a direction in which both ends of the suture body are fixed and connected to a plurality of pin vise 20, and are installed to face different directions along the outer circumferential surface of the suture body by vertical rotation. Fine protrusions 14 may be created.

The pin vise 20 may rotate the whole body of the suture at the moment the molding mold 40 moves, and may stop the rotation of the whole body of the suture at the moment when the molding mold 40 compresses the entire body of the suture.

According to an embodiment of the present invention, the microprotrusions 14 of the suture 10 forming the three-dimensional protrusions are formed by taking a forming mold while moving the whole body of the suture connected through the protrusion forming device 64 at regular intervals. Alternatively, by increasing the length of the molding mold, the suture may be formed by pressing without moving the entire body.

According to an embodiment of the present invention, the manufacturing apparatus may connect the suture body to a length of 30 to 40 cm and rotate it 15 times to form three-dimensional microprotrusions, but is not necessarily limited thereto.

Referring to (b) of FIG. 4A , the protrusion forming apparatus 64 may undergo a press process, a burr removal process, a rotation process, and a hardening process process.

The protrusion forming device 64 can first compress the suture body with a roll mill or a compression press, and secondly process it into a microprotrusion shape and remove the burr, and rotate the processed suture body through a ossification and hardening process. Through this process, 3D microprotrusions can be formed on the whole body of the suture. Here, the roll and/or compression press may form the suture body like kalguksu noodles.

The protrusion forming device 64 is processed in the shape of a fine protrusion through a mold that only moves up and down in the press process, and it can be processed by moving the processing part by 2 cm. At this time, the protrusion forming device 64 moves while rotating the suture body, so that the suture body forming 3D-shaped microprotrusions can be processed.

According to an embodiment of the present invention, the protrusion forming device 64 may rotate the suture whole body when making the suture whole body compressed with a roll mill or a compression press, but when compressed, a two-dimensional wide part is Because it has to be processed, the pressing press and the microprotrusion processing part can process the same 2cm increments equally.

5 and 6 are views showing the manufacture of microprotrusions according to an embodiment of the present invention.

According to an embodiment of the present invention, the suture 10 forming the three-dimensional protrusion is connected to the pin vise 20 in the manufacturing apparatus of FIG. 4 to form three-dimensional microprotrusions through a roll mill, rotation processing, etc. can Here, the three-dimensional microprotrusions may be shaped by a molding mold.

Figure 5 (a) is a view of manufacturing a suture body using a roll mill, Figure 5 (b) is a view of manufacturing a suture body using an outflow mold.

According to one embodiment of the present invention, after mounting a polydioxanone suture of USP 2 size (diameter 0.59 mm) or USP 3 size (diameter 0.65 mm) made of single fibers to the spill mold, 140 kgf / ㎠ at 90 ° C. Compression molding was performed for 1 to 5 seconds under pressure. The thickness of the burr was less than 50 μm, and the molded foam and the burr were completely separated by the outflow space without cracking. The primary molded form was converted into a secondary molded foam by heating it to a temperature above the glass transition temperature (about 45℃ to about 80℃ for 2 hours or more with a tensile force of 5N or more applied to both ends. Size of the microprotrusions formed on the primary molded foam was 200μm to 400μm in height, 1000μm to 3000μm in length, 120° to 170° anterior angle, and 30° to 60° posterior angle.

According to one embodiment of the present invention, after mounting a polydioxanone suture of USP 2 size (diameter 0.59 mm) or USP 3 size (diameter 0.65 mm) made of single fibers to the spill mold, 140 kgf / ㎠ at 90 ° C. Compression molding was performed for 1 to 5 seconds under pressure. The thickness of the burr was less than 50 μm, and the molded foam and the burr were completely separated by the outflow space without cracking. The primary molded foam was heated at a temperature of 90°C in a vacuum for 24 hours to be converted into a secondary molded foam, and a force of 5N or more and a rotation of 72°/cm were applied to both ends of the primary molded foam. The spinous protrusions of the secondary molded form are positioned at positions that rotate by 30° in both directions, so that they can have a helical multidirectional structure.

6 is a view of manufacturing a suture body through rotation processing.

Rotational processing includes a first embodiment in which the molding mold is moved up and down and the fine protrusions 14 are generated while rotating the thread, and a second embodiment in which the molding mold 40 itself is rotated using a cylinder 50. can

According to an embodiment of the present invention, in the second embodiment, the molding mold may form an angle of 30° with the suture body connected between the pin visees at both ends, and may be rotated by 60° in total and is necessarily limited thereto. it is not

According to an embodiment of the present invention, the shape of the suture body in which the three-dimensional protrusion is formed is not deformed even when the rotation process is applied, and the rotation of the molding mold 40 itself is not rotated by 360°, but the mainspring is wound and then back to the original shape. It can rotate as if returning to a state. Specifically, it is possible to use a method of holding the cylinder 50 at 0° horizontally, rotating it at 0°, 90°, 180°, and 270°, and then returning to 270°, 180°, 90°, and 0°. .

According to an embodiment of the present invention, the cylinder 50 may be implemented as a booster cylinder that converts pneumatic pressure into hydraulic pressure, but is not necessarily limited thereto. Preferably, the cylinder 50 can be used at 8 atmospheres, and the microprotrusions 14 are formed by pressing the molding mold 40 for 2 to 3 seconds, or the molding mold using a hydraulic press (15 tons or more). You can form the microprotrusions 14 by pressing for 2-3 seconds. At this time, this process can be performed by transferring the temperature from the bottom, and the rotation of the suture body is stopped at the moment of taking the suture body through the molding mold 40, and after taking it, it can be rotated again.

The molding mold used to form three-dimensional microprotrusions can move up and down with an interval of 1 to 50 cm. At this time, when the spacing between the molding molds is smaller than 1 cm and larger than 50 cm, there is a problem in that the interval between the fine projections is not constant, deviated from the timing of taking pictures to form the fine projections.

In addition, the molding mold may imprint the microprotrusion shape on the suture body at a pressure of 3 kgf/cm² to 20 kgf/cm². At this time, when the pressure is less than 3 kgf/cm², there is a problem in that the shape of the microprotrusions cannot be accurately realized. There may be issues that can break.

7 and 8 are exemplary views showing a suture forming a three-dimensional protrusion according to an embodiment of the present invention.

7 and 8 , the suture 10 forming the three-dimensional protrusion includes a suture body 12 and microprotrusions 14 . The suture 10 forming the three-dimensional protrusion may omit some of the various components exemplarily illustrated in FIG. 3 or may additionally include other components.

According to an embodiment of the present invention, the suture 10 for forming the three-dimensional protrusion is centered on the suture body connected through each vise pin, and the angle of the molding mold is adjusted, the shape of the molding mold is changed, The microprotrusions 14 may be formed so as to face different directions through a post-processing process or the like.

The suture body 12 may be formed in a linear structure including elastic force.

The suture body 12 may be implemented as a whole body of a suture, and may represent a thread that does not include the microprotrusions 14 .

The microprotrusions 14 may be formed on the outer surface of the suture body 12 .

The microprotrusions 14 may be formed at regular intervals throughout the suture body 12 in a three-dimensional three-dimensional structure.

The microprotrusions 14 have a protrusion shape formed around the suture body 12 and may be implemented with barbs, etc., but is not necessarily limited thereto. Here, the barb refers to the shape of a hook in the shape of a goose, such as fishing.

According to an embodiment of the present invention, the suture 10 forming the three-dimensional protrusion uses a main component included in the suture having viscoelasticity and elastic force (restorative force).

The suture 10 forming the three-dimensional protrusion is polydioxanone (PDO, Polydioxanone), polylactic acid (PLLA, Poly-(L-Lactic) Acid), polyglycolic acid (PCL, Polyglycolic Acid), polycaprolactone ( Poly Caprolactone) and a bioabsorbable medical polymer material made of any one selected from copolymers thereof or a bioabsorbable medical polymer material made of any one selected from polyprophylene, nylon, and mixtures thereof.

Polydioxanone (PDO, polydioxanone) accounts for more than 80% of the meltable thread market, and is a component mainly used in sutures. Polydioxanone is hydrolyzed and excreted in the urine, and when decomposed, it stimulates collagen production to promote skin regeneration to improve skin elasticity, and is weak to heat and can be decomposed for 6 to 8 months.

Polylactic acid (PLLA, poly-(l-lactic) acid) is a raw material for Sculptra, and after about 2 months, it starts to decompose into H2O, CO2, and glucose, and through decomposition, continuous collagen can be produced. The polylactic acid thread is hard and stiff without elasticity, causing foreign body sensation and pain after insertion, and can be maintained for 18 months.

Poly Caprolactone, a raw material for Ellanse, is decomposed into H2O and CO2, and collagen is continuously generated through decomposition. Polycaprolactone can be maintained for 24 months.

Thread lifting is a cutting thread, two-way cock seal (2D), Epiticon, N-Fix, Concertina, Scaffold, TESSLIFT-SOFT ( Various types of PDO yarn such as cutting protrusion center thread + mesh) can be used. The suture 10 forming the three-dimensional protrusion of the present invention may be implemented as a PDO thread forming the three-dimensional protrusion, but is not necessarily limited thereto.

The suture 10 forming the three-dimensional protrusion is for fixing facial tissue (lifting thread) of an absorbent material (PDO) used when pulling or fixing skin tissue for the purpose of improving wrinkles.

Preferably, the suture 10 forming a three-dimensional protrusion may be used as a lifting thread for fixing facial tissue of an absorbent material having a 3D three-dimensional protrusion of 360° used when pulling or fixing skin tissue for the purpose of improving wrinkles, etc. It is not necessarily limited to this. The suture 10 forming the three-dimensional protrusion may be cut after use to a required length.

According to an embodiment of the present invention, the suture 10 forming a three-dimensional protrusion implements a protruding external structure (protrusion) through a molding (PRESS process) method, not a method of cutting the PDO thread, and before the PDO thread By applying rotational force to the body, a 3D three-dimensional surface with a 360° tornado structure can be realized to enhance the lifting effect and strengthen the tensile force.

According to an embodiment of the present invention, the strength of the suture 10 forming the three-dimensional protrusion may be increased by about 10% or more when subjected to a 360° rotation process. Here, the process of giving the 360° rotation process may refer to a process of passing through the glass transition temperature or more for 2 hours or more while having a tensile force of 5N or more. For example, the strength of the suture 10 for forming the three-dimensional protrusion is measured to be about 35N compared to 26.3N based on the USP 2-0 strength standard, and it may be measured to be 38N after the rotation and curing processes are performed. Conversely, if too strong a tensile force (more than 5N but stronger than the tensile strength of the suture body itself, for example, 26.3N according to USP 2-0) is applied, the thread may break.

According to an embodiment of the present invention, in the suture 10 forming the three-dimensional protrusion, the microprotrusions 14 may maintain an interval of 0.25 to 10 mm and form an angle of 30 to 90°. Specifically, the microprotrusions 14 are all implemented to maintain the same spacing and angle, the spacing may be different from each other, the angle may be different, or both the spacing and the angle may be implemented differently. In addition, although the microprotrusions 14 are shown to be formed in a spiral direction, the present invention is not limited thereto, and may be formed in a random direction.

Figure 8 (a) is a view showing the structure of the front (cross-section) of the suture forming the three-dimensional protrusion, Figure 8 (b) is a view showing the structure of the side (side) of the suture forming the three-dimensional protrusion .

Referring to (a) of FIG. 8 , it can be seen that the microprotrusions 14 are formed in all directions on the circular suture body 12 of the suture 10 forming the three-dimensional protrusion.

Referring to FIG. 8 , the suture 10 forming the three-dimensional protrusion is illustrated in which eight microprotrusions 14 are repeated in plurality at intervals of 45°, but the present invention is not limited thereto.

Accordingly, the suture 10 forming the three-dimensional protrusion is implemented as a three-dimensional three-dimensional structure by molding the suture body 12 by rotating the plurality of microprotrusions 14 by 360°. Specifically, when the N microprotrusions 14 are rotated and molded by 360°, the angle at which each microprotrusion 14 is disposed may be an angle obtained by dividing 360° by N.

9 is an exemplary view illustrating the shape of a suture forming a three-dimensional protrusion after time has elapsed according to an embodiment of the present invention.

Figure 9 (a) shows the initial shape of the suture 10 for forming a three-dimensional protrusion, Figure 9 (b) shows the shape of the suture 10 for forming a three-dimensional protrusion after one week, Figure 9 (c) shows the shape of the suture 10 forming a three-dimensional protrusion after two weeks, and FIG. 9 (d) shows the shape of the suture 10 forming a three-dimensional protrusion after two months.

Referring to FIG. 9 , the suture 10 forming the three-dimensional protrusion may maintain the same shape as the first time even with the passage of time, and the shape of the microprotrusion 14 formed on the suture body 12 may also not change. .

The suture 10 forming the three-dimensional protrusion may be maintained for a long time by forming the protrusion by a molding method. For example, the suture 10 forming the three-dimensional protrusion is decomposed after 6 to 8 months, and even after decomposition, collagen production can be induced for a certain period of time, and the effect can be maintained for about 1 year.

10 is a view comparing the suture forming the three-dimensional protrusion and the suture forming the cut protrusion according to an embodiment of the present invention.

Figure 10 (a) is a view showing a suture forming a three-dimensional protrusion according to an embodiment of the present invention, Figure 10 (b) is a suture forming a three-dimensional protrusion according to an embodiment of the present invention It is a drawing showing

The suture 10 forming the three-dimensional protrusion can have excellent tensile strength and strong fixing force because there is no loss of the suture body 12 by the press-molding manufacturing method.

The strength area may represent a cross-sectional length of the suture body 12 .

In the strength region of the suture 10 forming the three-dimensional protrusion, there is no loss of a separate suture body 12 by forming the microprotrusions 14 on the outer surface of the suture body 12 in a press-molding manufacturing method. The entire length of the cross-section in (12) is shown.

The strength region of the suture in FIG. 10 (b) is a portion obtained by cutting a part of the suture body 12 to form microprotrusions, and represents a portion obtained by subtracting the cross-sectional length from the entire cross-sectional length of the suture body 12 to the cut portion. .

Accordingly, it can be confirmed that the suture 10 forming the three-dimensional protrusion of FIG. 10 (a) has better supporting strength and tensile strength than the suture of FIG. 10 (b). Here, the tensile strength may represent the maximum stress that the object can withstand the pulling force, and it can also be seen that the durability (Durability) is better. Durability is the property of a material to endure for a long time without being deteriorated or deformed in its original state, which can be confirmed through FIG. 9 .

It can secure sufficient tissue fixation force required during surgical operation and has the function of promoting the regeneration of surrounding soft tissues. In addition, the medical suture manufactured according to the present invention does not form a cutting angle such as cutting the surface of the original suture yarn as shown in FIG. 10 (b), and does not give a physical knot. It may have microprotrusions on the surface as shown in (a) of FIG.

11 is a graph showing a comparison result between the suture forming the three-dimensional protrusion and the suture forming the cut protrusion according to an embodiment of the present invention.

Referring to the graph on the left of FIG. 11A , it can be seen that the suture 10 forming the three-dimensional protrusion has about three times superior tensile strength than the suture 10 forming the cut protrusion. In this case, the tensile strength may be viewed as anchoring strength.

Referring to the graph on the right of FIG. 11A , it can be seen that the suture 10 forming the three-dimensional protrusion has about 3 times better tension than the suture 10 forming the cut protrusion. In this case, the tension can also be viewed as a tensile property.

Referring to FIG. 11B , it can be seen that the suture 10 forming the three-dimensional protrusion has a higher tensile strength over time than the suture 10 forming the cut protrusion.

Even if all the components constituting the embodiment of the present invention described above are described as being combined or operated in combination, the present invention is not necessarily limited to this embodiment. That is, within the scope of the object of the present invention, all the components may operate by selectively combining one or more.

The above description is merely illustrative of the technical idea of the present invention, and those of ordinary skill in the art to which the present invention pertains may make various modifications, changes and substitutions within the scope without departing from the essential characteristics of the present invention. will be. Accordingly, the embodiments disclosed in the present invention and the accompanying drawings are intended to explain, not to limit the technical spirit of the present invention, and the scope of the technical spirit of the present invention is not limited by these embodiments and the accompanying drawings . The protection scope of the present invention should be construed by the following claims, and all technical ideas within the scope equivalent thereto should be construed as being included in the scope of the present invention.

10: Suture forming a three-dimensional projection
12: suture body
14: microprojection

Claims (18)

In the method for manufacturing a suture by a suture manufacturing apparatus,
Rotating the suture body having an elastic force, and forming a three-dimensional micro-protrusion (Micro Cog) on the surface of the suture body through a molding mold; and
Under the conditions of the glass transition temperature or lower below the melting point of the main component contained in the suture body, the spatial position of the molding mold or the suture body is rotated to apply tensile and rotational forces to the whole body of the suture in which the microprotrusions are formed. A method of manufacturing a suture comprising the step of preparing a suture having a three-dimensional structure by adding the suture. According to claim 1,
The step of forming the three-dimensional micro-protrusions (Micro Cog) is,
Both ends of the suture whole body are connected to a suture fixing part holding the suture body, respectively, and rotated to rotate the suture, and the suture body rotated to manufacture the suture body in which the three-dimensional microprotrusions are formed. Suture manufacturing method, characterized in that processing. 3. The method of claim 2,
The step of forming the three-dimensional micro-protrusions (Micro Cog) is,
When the suture whole body is fixed at both ends to the respective suture fixing parts and rotates a preset number of times, the microprotrusions are formed on the rotated suture body or when the rotated suture is unscrewed after curing, rotation 0% to 30% decrease in number,
When the suture whole body is processed through the molding mold, both ends of the suture body are fixed and moved at regular intervals of 1 cm to 30 cm and may be formed by taking the molding mold, or the length of the molding mold A method of manufacturing a suture, characterized in that it is formed by taking the molding mold without moving the suture whole body by implementing it to correspond to the length of the suture body. According to claim 1,
The step of forming the three-dimensional micro-protrusions (Micro Cog) is,
A first protrusion manufacturing step of using a roll mill or a compression press to prepare the suture body in which the microprotrusions are formed;
a second protrusion manufacturing step of manufacturing the suture body in which the microprotrusions are formed using an overflow mold; and
A method for manufacturing a suture, characterized in that the suture manufacturing method is performed by selecting one of the third protrusion manufacturing steps of manufacturing the suture whole body in which the fine protrusions are formed by rotationally processing the suture body. 5. The method of claim 4,
The first protrusion manufacturing step of using the roll mill to prepare the suture body in which the fine protrusions are formed,
A suture manufacturing method, characterized in that the rotated suture body is pressed using the roll mill, and the suture body is manufactured through the forming mold. 5. The method of claim 4,
The second protrusion manufacturing step of manufacturing the suture body in which the microprotrusions are formed using the flow mold,
In the pouring mold, the main component contained in the suture body is heated under a temperature condition of below the melting point to above the glass transition temperature and under a certain range of pressure conditions, and the suture is subjected to a solid-phase forming method A method for manufacturing a suture, characterized in that the whole body is manufactured. 5. The method of claim 4,
A third protrusion manufacturing step of manufacturing the whole body of the suture in which the microprotrusions are formed by the rotation processing,
a first processing step of rotating the suture body connected to both ends of the suture fixing part and compressing the suture body by moving the molding mold up and down; and
Rotating the suture whole body connected to both ends of the suture fixing part, and selecting one of the second processing steps of compressing the suture whole body by rotating the molding mold itself using at least one cylinder and moving up and down A method of manufacturing a suture, characterized in that. 8. The method of claim 7,
The second processing step,
A method of manufacturing a suture, characterized in that the cylinder is disposed on the suture in an oblique line to form a certain atmospheric pressure to rotate the molding mold, and the molding mold is rotated by 40° to 70° using the diagonally arranged cylinder. . 9. The method of claim 8,
The molding mold,
When rotating in a clockwise or counterclockwise direction using the cylinder, after rotating within 360°, the suture manufacturing method, characterized in that it returns to its original state by rotating in the opposite direction to the rotating direction. 8. The method of claim 7,
The step of forming the three-dimensional micro-protrusions (Micro Cog) is,
The suture manufacturing method, characterized in that the suture whole body rotates at the moment the molding mold moves, and the rotation of the suture whole body is stopped at the moment the molding mold compresses the suture whole body. The suture body is formed in a linear structure having an elastic force; and
and a micro cog formed on the outer surface of the suture body,
The suture, characterized in that the microprotrusions are formed at regular intervals throughout the suture body in a three-dimensional three-dimensional structure. 12. The method of claim 11,
The main component included in the suture that forms the three-dimensional protrusion is,
Bioabsorbable medical polymer consisting of any one selected from Polydioxanone, Poly-(L-Lactic) Acid, Polyglycolic Acid, Poly Caprolactone, and copolymers thereof A suture, characterized in that it is a bio-absorbable medical polymer material made of any one selected from material or polypropylene, nylon, and mixtures thereof. 12. The method of claim 11,
The microprotrusions are
A plurality of sutures are implemented to surround the suture body with a 360° tornado structure along the outer surface of the suture body, and a preset angle is formed in the suture body in an oblique direction. a supply unit for supplying a suture body having an elastic force;
a discharge unit for discharging the suture body in which three-dimensional microprotrusions are formed on the surface of the suture body; and
It is installed between the supply part and the discharge part, and by fixing the suture whole body to deform the spatial position of the molding mold, and applying tensile and rotational force to the suture whole body in which the microprotrusions are formed, a suture having a three-dimensional structure is manufactured A suture manufacturing apparatus comprising a protrusion forming apparatus. 15. The method of claim 14,
The protrusion forming device,
a plurality of suture fixing units in which at least two form a pair to fix both ends of the suture body;
a jig for supporting the plurality of suture fixing parts provided at both ends of the suture body in a state fixed to a plate;
a support part connecting both ends of the jig to support the jig and the suture fixing part; and
A suture manufacturing apparatus comprising a molding mold whose spatial position is deformed to form three-dimensional microprotrusions on the surface of the suture body fixed to the suture fixing part. 16. The method of claim 15,
The protrusion forming device,
Further comprising a cylinder connected to the molding mold to rotate the molding mold,
The cylinder rotates the molding mold clockwise or counterclockwise, and after rotating the molding mold within 360°, the suture manufacturing apparatus, characterized in that it returns to its original state by rotating in the opposite direction to the rotated direction. 16. The method of claim 15,
The molding mold,
Both ends of the suture body are fixed to the plurality of suture fixing units and are installed spaced apart from each other at regular intervals in the connected direction,
Suture manufacturing apparatus, characterized in that the microprotrusions are generated so as to face different directions along the outer circumferential surface of the suture body by vertical movement. 16. The method of claim 15,
The suture fixing part,
Suture manufacturing apparatus, characterized in that the rotation of the suture whole body is rotated at the moment the molding mold moves, and the rotation of the suture whole body is stopped at the moment when the molding mold presses the suture whole body.

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