KR20220020228A - Stable pharmaceutical formulation - Google Patents

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KR20220020228A
KR20220020228A KR1020210105647A KR20210105647A KR20220020228A KR 20220020228 A KR20220020228 A KR 20220020228A KR 1020210105647 A KR1020210105647 A KR 1020210105647A KR 20210105647 A KR20210105647 A KR 20210105647A KR 20220020228 A KR20220020228 A KR 20220020228A
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binding molecule
pharmaceutical formulation
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stable pharmaceutical
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김광우
김수정
노지원
오준석
이재빈
한원용
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(주)셀트리온
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Abstract

The present invention relates to a stable pharmaceutical preparation, and more particularly, to a pharmaceutical preparation comprising a binding molecule for a SARS-coronavirus-2 surface spike protein (S protein). The stable pharmaceutical preparation according to the present invention has excellent long-term storage stability under temperature conditions such as accelerated conditions and severe conditions, and thus can maintain excellent stability even under physical stress conditions such as light, freezing and thawing, and shaking.

Description

안정한 약제학적 제제{STABLE PHARMACEUTICAL FORMULATION}STABLE PHARMACEUTICAL FORMULATION

본 발명은 안정한 약제학적 제제에 관한 것으로, 보다 구체적으로는, 사스-코로나바이러스-2 표면의 스파이크 단백질(Spike protein, S protein)에 대한 결합 분자를 안정하게 보존할 수 있는 약제학적 제제에 관한 것이다.The present invention relates to a stable pharmaceutical preparation, and more particularly, to a pharmaceutical preparation capable of stably preserving a molecule binding to a spike protein (S protein) on the surface of SARS-coronavirus-2 .

사스-코로나바이러스-2(severe acute respiratory syndrome coronavirus 2, SARS-CoV-2)는 유전적 배열(DNA sequencing)상 전도 기능(Positive sense)이 있는 단일 가닥 RNA(single-stranded RNA) 코로나바이러스이다. SARS-CoV-2는 인간에게 전염성이 있고 코로나바이러스감염증-19(coronavirus disease 2019, COVID-19)의 원인이다. COVID-19의 최초 발생지는 중국 후베이성의 우한시이다. SARS-coronavirus-2 (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) is a single-stranded RNA coronavirus with a positive sense in genetic sequencing (DNA sequencing). SARS-CoV-2 is contagious to humans and is the cause of coronavirus disease 2019 (COVID-19). The first outbreak of COVID-19 was in Wuhan, Hubei Province, China.

SARS-CoV-2에 감염된 사람들은 열, 기침, 호흡 곤란, 설사와 같이 경증 내지 중증의 증상을 보일 수 있다. 합병증이나 병을 가진 사람들, 노인은 사망할 가능성이 크다.People infected with SARS-CoV-2 may have mild to severe symptoms such as fever, cough, shortness of breath, and diarrhea. People with complications or diseases and the elderly are more likely to die.

특히 심장질환 및 당뇨병 등의 기저질환 보유자가 감염에 더 취약하며, 합병증이나 장기 손상 등을 겪기 때문에 조기 발견과 치료가 매우 중요하다. 2019년 12월 8일부터 2020년 3월 20일 현재까지 245,550명의 환자가 발생하였고, 그 중 10,049명이 사망하여 치사율은 4.09%에 달한다(WHO). 2020년 현재까지 한국을 포함한 177개국에서 발생하였다. In particular, people with underlying diseases such as heart disease and diabetes are more susceptible to infection and suffer complications or organ damage, so early detection and treatment are very important. From December 8, 2019 to March 20, 2020, there were 245,550 cases, of which 10,049 died, resulting in a fatality rate of 4.09% (WHO). As of 2020, it has occurred in 177 countries including Korea.

현재 코로나바이러스감염증-19(coronavirus disease 2019, COVID-19)의 치료제는 없고, 기존 치료제를 환자에게 투여하여 치료 효과를 기대하고 있는 실정이다. 에볼라 치료제 혹은 치료 후보 물질인 항바이러스제 파비피라비르 (favipiravir), 렘데시비르 (remdesivir), 갈리데시비어 (galidesivir)와 C형 간염 치료제인 리바비린 (ribavirin) 등을 COVID-19 치료제로 사용하고 있다. 또한, 말라리아치료제 클로로퀸 (Chloroquine)도 COVID-19에 치료 효과를 보이는 것으로 나타나 공개 임상시험 진행 중에 있다. 그러나 C형 간염 치료제인 리바비린은 빈혈과 같은 부작용이 심할 수 있고, 항바이러스제인 인터페론 (interferon)도 여러 가지 부작용을 우려하여 주의해서 사용할 것을 권고하고 있다. Currently, there is no treatment for coronavirus disease 2019 (COVID-19), and the existing treatment is administered to the patient to expect a therapeutic effect. Antiviral agents favipiravir, remdesivir, and galidesivir, which are Ebola treatment or treatment candidates, and hepatitis C treatment ribavirin are being used as COVID-19 treatments. In addition, the antimalarial drug Chloroquine has been shown to have a therapeutic effect on COVID-19 and is undergoing public clinical trials. However, hepatitis C treatment ribavirin may have severe side effects such as anemia, and the antiviral drug interferon is also recommended to be used with caution due to concerns about various side effects.

비록 이러한 약물들이 COVID-19 환자 치료에 활용되어 치료 효과를 보고 있지만, 아직 어떠한 근거로 치료 효과를 내는지는 아직 명확히 입증되지 않았다. 중국에서 COVID-19 회복 환자의 현장을 주입하는 혈장 요법을 시행하여 중증 환자의 치료에 효과를 보였다고 발표하였으나, 치료 효과가 불분명하고 불확실성이 크다.Although these drugs have been used to treat COVID-19 patients and are seeing therapeutic effects, it has not yet been clearly demonstrated on what basis they have therapeutic effects. In China, it was announced that the on-site injection of plasma therapy for patients recovering from COVID-19 was effective in the treatment of severely ill patients, but the therapeutic effect is unclear and there is great uncertainty.

한국의 경우, COVID-19 중앙임상 TF(테스크포스)가 2020년 2월 13일 COVID-19의 치료 원칙을 마련하여, 1차 치료제로 에이즈 치료제인 칼레트라 (Kaletra), 말라리아치료제인 클로로퀸과 하이드록시클로로퀸(Hydroxychloroquine)을 권하며, 리바비린과 인터페론은 부작용을 우려해 1차 치료제로 권하지 않기로 발표했다. 경증이거나 젊은 환자, 발병 10일이 지난 경우에는 항바이러스제를 투여하지 않아도 증상이 호전된다고 판단하고, 고령자, 기저질환자, 중증 환자에게는 항바이러스 치료제를 투여하기로 합의했다. In Korea, the COVID-19 Central Clinical Task Force (Task Force) prepared the treatment principle for COVID-19 on February 13, 2020, and as the first-line treatment, AIDS treatment Kaletra, malaria treatment chloroquine and hydroxy Chloroquine (Hydroxychloroquine) is recommended, and ribavirin and interferon are not recommended as first-line treatment due to concerns about side effects. In mild or young patients, if 10 days have passed since the onset of the disease, it was judged that the symptoms improved even if antiviral drugs were not administered.

미국 CDC는 i) COVID-19가 계절성 유행 바이러스가 아닌 메르스처럼 토착화되어 감염을 일으킬 수 있다고 발표하였고, ii) 바이러스가 올해 또는 내년 어느 시점에 커뮤니티로 전파될 수 있으며, 비록 코로나 바이러스가 실제 커뮤니티에 잠복되어 있다는 증거는 없으나, 데이터 기반으로 결론을 내릴 수 있도록 감시강화 필요성을 언급하였다(2020.2.13).The U.S. CDC has announced that i) COVID-19 can become indigenous and cause infections like MERS rather than a seasonal virus, and ii) the virus can spread to communities at some point this year or next year, even though the coronavirus is Although there is no evidence that it is hidden in the

한국 질병관리본부(현, 질병관리청)는 i) COVID-19도 인플루엔자처럼 장기적으로 유행할 수 있다고 판단하여, 인플루엔자와 같이 감시 체계에 포함하겠다고 발표하였고, ii) 사람 사이에 유행하는 코로나바이러스(4종)도 겨울~봄에 유행하고 있어서 COVID-19도 토착화될 수 있다는 가능성을 열어두고 있다(2020.2.17).The Korea Centers for Disease Control and Prevention (currently, the Korea Centers for Disease Control and Prevention) announced that i) that COVID-19 could also spread like influenza for a long time and that it would be included in the surveillance system like influenza, and ii) a coronavirus that spreads among people (4 species) is also prevalent in winter and spring, leaving open the possibility that COVID-19 may also become indigenous (2020.2.17).

사스나 메르스와는 다르게 COVID-19의 세계적 유행 (pandemic) 현실화에 대한 우려가 있지만 봄 이후 (4월) 소강 상태가 될 가능성도 있어, 추이를 보며 신중하게 접근하는 전문가들이 많다. 아직 코로나19에 대한 정보 부족으로 전문가들도 추후 전개 양상에 대해서는 의견이 분분하나, 단시일 내에 해결되리라 전망하는 전문가는 거의 없다. COVID-19의 유행 양상과 특징이 정확히 분석되고 이번 COVID-19로 인한 위기 상황이 얼마나 지속되는지에 영향을 받겠지만, 무증상 감염자가 전세계에 퍼지게 될 경우 풍토병화 될 가능성에 대한 우려가 있다. 세계적으로 COVID-19 재발병 가능성에 대한 대응책 마련이 시급하다. Unlike SARS and MERS, there are concerns about the realization of a global pandemic of COVID-19, but there is a possibility that there may be a lull after spring (April). Due to the lack of information on COVID-19, experts also have differing opinions about the future development, but few experts predict that it will be resolved in a short time. Although the pattern and characteristics of the COVID-19 epidemic will be accurately analyzed and will be affected by how long the crisis caused by this COVID-19 will last, there are concerns about the possibility that asymptomatic infections may become endemic if they spread around the world. It is urgent to prepare countermeasures against the possibility of a recurrence of COVID-19 worldwide.

SARS-CoV-2 바이러스의 스파이크 단백질(Spike protein, S protein)을 표적으로 하는 결합 분자를 보다 안정하게 보존할 수 있는 제형은 아직까지 개발되지 않았다. 이에 따라, 본 발명자들은 안정성이 우수한 제형을 개발하고자 지속적인 연구를 거듭한 결과, 본 발명을 최종 완성하였다.A formulation capable of more stably preserving a binding molecule targeting the SARS-CoV-2 virus spike protein (S protein) has not yet been developed. Accordingly, as a result of continuous research to develop a formulation having excellent stability, the present inventors have finally completed the present invention.

본 발명자들은 사스-코로나바이러스-2(SARS-CoV-2) 표면의 스파이크 단백질(Spike protein, S protein)에 결합하는 중화 결합 분자를 안정하게 보존할 수 있는 약제학적 제제를 개발하였다. The present inventors have developed a pharmaceutical preparation capable of stably preserving a neutralizing binding molecule that binds to a spike protein (S protein) on the surface of SARS-CoV-2.

이에, 본 발명이 해결하고자 하는 과제는 사스-코로나바이러스-2(SARS-CoV-2) 표면의 스파이크 단백질(Spike protein, S protein)에 결합하는 중화 결합 분자를 포함하는, 안정한 약제학적 제제, 바람직하게는 장기 보관시 안정한 약제학적 제제를 제공하는 것이다.Accordingly, the problem to be solved by the present invention is a stable pharmaceutical preparation, preferably comprising a neutralizing binding molecule that binds to the spike protein (S protein) on the surface of SARS-CoV-2 (SARS-CoV-2) The goal is to provide a pharmaceutical formulation that is stable for long-term storage.

상기 과제를 해결하고자, 본 발명은 (A) 사스-코로나바이러스-2(SARS-CoV-2) 표면의 스파이크 단백질(Spike protein, S protein)에 결합하는 중화 결합 분자, (B) 완충제, (C) 안정화제 및 (D) 계면활성제를 포함하는 안정한 약제학적 제제를 제공한다. In order to solve the above problems, the present invention provides (A) a neutralizing binding molecule that binds to the spike protein (S protein) on the surface of SARS-coronavirus-2 (SARS-CoV-2), (B) a buffer, (C ) a stabilizer and (D) a surfactant.

항체 등의 중화 결합 분자는 통상적인 유기 및 무기 약물에 비해 크고 복잡한 구조를 가진다. 그러므로, 항체 등의 중화 결합 분자를 포함하는 약제학적 제제는 항체 등의 중화 결합 분자의 안정성을 유지해야 하는 특별한 문제를 지니고 있다. Neutralizing binding molecules such as antibodies have larger and more complex structures than conventional organic and inorganic drugs. Therefore, a pharmaceutical preparation containing a neutralizing-binding molecule such as an antibody has a special problem in that the stability of the neutralizing-binding molecule, such as an antibody, must be maintained.

항체 등의 중화 결합 분자의 안정성은 이온 강도, pH, 온도, 동결/해동의 반복 주기, 항체 등의 중화 결합 분자 농도와 같은 인자들에 의해 영향을 받을 수 있다. 활성 항체 등의 중화 결합 분자는 변성, 응집(용해성 및 불용성 응집물의 형성), 침전 및 흡착을 포함하는 물리적 불안정성 또는 라세미화, 베타-제거, 이황화 교환, 가수분해, 탈아미드화 및 산화를 포함하는 화학적 불안정성에 의하여 손실이 발생할 수 있다. 이러한 물리적 및 화학적 불안정성은 잠재적으로 항체 등의 중화 결합 분자의 저하된 생물학적 활성, 증가된 독성 및/또는 증가된 면역원성을 갖는 항체 등의 중화 결합 분자 부산물 또는 유도체의 형성을 초래할 수 있다.The stability of a neutralizing binding molecule, such as an antibody, may be affected by factors such as ionic strength, pH, temperature, repeated freeze/thaw cycles, and concentration of a neutralizing binding molecule, such as an antibody. Neutralizing binding molecules, such as active antibodies, exhibit physical instability including denaturation, aggregation (formation of soluble and insoluble aggregates), precipitation and adsorption, or physical instability, including racemization, beta-elimination, disulfide exchange, hydrolysis, deamidation and oxidation. Loss may occur due to chemical instability. Such physical and chemical instability can potentially result in the formation of neutralizing binding molecule byproducts or derivatives, such as antibodies, with reduced biological activity, increased toxicity, and/or increased immunogenicity of the neutralizing binding molecule, such as an antibody.

항체 등의 중화 결합 분자의 안정한 액체 약제학적 제제의 개발에 사용될 수 있는 다양한 부형제들이 제시되고 있지만, 항체 등의 중화 결합 분자마다 고유의 물리화학적인 성질을 가지기 때문에, 다른 항체 등의 중화 결합 분자를 사용한 종래의 제제를 고려해 특정 항체 등의 중화 결합 분자가 가지는 불안정성 문제를 극복하기 위한 부형제의 종류 및 양을 예측하는 것은 실질적으로 불가능하다. 또한, 특정 항체 등의 중화 결합 분자를 약제학적 제제 내에서 화학적으로 그리고 생물학적으로 안정하게 유지시키기 위한 항체 등의 중화 결합 분자의 농도, pH, 부형제의 농도 등의 최적 조건을 도출하는 것은 어려우며 많은 시간과 노력이 필요하다.Various excipients that can be used for the development of stable liquid pharmaceutical formulations of neutralizing-binding molecules such as antibodies have been proposed, but since each neutralizing-binding molecule such as an antibody has its own physicochemical properties, neutralizing-binding molecules such as other antibodies have been proposed. It is practically impossible to predict the type and amount of excipients to overcome the problem of instability of a neutralizing binding molecule such as a specific antibody in consideration of the conventional formulation used. In addition, it is difficult and time-consuming to derive optimal conditions such as the concentration of neutralizing-binding molecules such as antibodies, pH, and concentration of excipients for maintaining chemically and biologically stable neutralizing-binding molecules such as specific antibodies in pharmaceutical formulations and effort are required.

현재, 사스-코로나바이러스-2 표면의 스파이크 단백질(Spike protein, S protein)에 결합하는 중화 결합 분자를 포함하는 안정한 약제학적 제제에 관한 선행 기술은 존재하지 않는다. 본 발명은 사스-코로나바이러스-2 표면의 스파이크 단백질(Spike protein, S protein)에 결합하는 중화 결합 분자와 완충제, 안정화제 및 계면활성제를 함께 포함하는 약제학적 제제 내에서 상기 중화 결합 분자의 고분자량 성분 및 불용성 이물의 숫자 형성을 감소시켜 이의 활성을 안정화 시키는 효과가 있음을 최초로 확인하였다.Currently, there is no prior art relating to a stable pharmaceutical preparation comprising a neutralizing binding molecule that binds to a spike protein (S protein) on the surface of SARS-coronavirus-2. The present invention relates to a high molecular weight of the neutralizing binding molecule in a pharmaceutical formulation comprising a neutralizing binding molecule that binds to a spike protein (S protein) on the surface of SARS-coronavirus-2 and a buffer, a stabilizer and a surfactant together. It was confirmed for the first time that there was an effect of stabilizing its activity by reducing the formation of the number of components and insoluble foreign substances.

이하 본 발명을 더욱 상세히 설명한다. Hereinafter, the present invention will be described in more detail.

본 발명은 코로나바이러스(Coronavirus), 바람직하게는 사스-코로나바이러스-2(SARS-CoV-2), 더욱 바람직하게는 사스-코로나바이러스-2(SARS-CoV-2) 표면의 스파이크 단백질(Spike protein, S protein)에 결합하는 중화 결합 분자를 포함하는 안정한 약제학적 제제에 관한 것이다.The present invention relates to a spike protein on the surface of a coronavirus, preferably SARS-coronavirus-2 (SARS-CoV-2), more preferably SARS-coronavirus-2 (SARS-CoV-2). , S protein) to a stable pharmaceutical formulation comprising a neutralizing binding molecule that binds.

본 발명에 있어, 상기 결합 분자는 사스-코로나바이러스-2 표면의 스파이크 단백질의 RBD(Receptor binding domain) 영역에 결합할 수 있다.In the present invention, the binding molecule may bind to the receptor binding domain (RBD) region of the spike protein on the SARS-coronavirus-2 surface.

본 발명에 있어, 본 발명의 사스-코로나바이러스-2(SARS-CoV-2) 표면의 스파이크 단백질(Spike protein, S protein, S 단백질)은 서열번호: 3841의 서열로 구성되거나, 이를 포함하는 것일 수 있으며, 이들의 유도체 및/또는 변이체를 포함하나, 이에 한정되지 않는다.In the present invention, the SARS-coronavirus-2 (SARS-CoV-2) surface spike protein (S protein, S protein) of the present invention consists of or includes the sequence of SEQ ID NO: 3841. and derivatives and/or variants thereof, but are not limited thereto.

본 발명에 있어, 본 발명의 사스-코로나바이러스-2(SARS-CoV-2) 표면의 스파이크 단백질의 RBD(Receptor binding domain) 영역은 서열번호: 3842의 서열로 구성되거나, 이를 포함하는 것일 수 있으며, 이들의 유도체 및/또는 변이체를 포함하나, 이에 한정되지 않는다.In the present invention, the SARS-CoV-2 (SARS-CoV-2) surface spike protein region of the present invention may consist of or include the sequence of SEQ ID NO: 3842. , derivatives and/or variants thereof.

본 발명에 있어, 본 발명에 따른 약제학적 제제는 액상일 수 있으나, 이에 한정되는 것은 아니다.In the present invention, the pharmaceutical formulation according to the present invention may be in a liquid form, but is not limited thereto.

본 발명의 일 구체예에서, 본 발명의 중화 결합 분자는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질에 우수한 결합능 및/또는 우수한 중화능을 나타낸다. 본 발명의 다른 구체예에서, 본 발명의 중화 결합 분자는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질에 돌연변이가 생긴 변이 바이러스에 우수한 결합능 및/또는 중화능을 나타낸다. 본 발명에 있어, 본 발명의 중화 결합 분자는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질의 RBD(Receptor binding domain) 영역에 결합하며 중화능 있는 결합 분자로 스크리닝된 결합 분자일 수 있다. 본 발명에 있어, 본 발명의 중화 결합 분자는 상기 RBD 영역 이외의 S 단백질의 다른 부위의 변이 바이러스에도 우수한 중화능을 나타낼 수 있으나, 이에 한정되는 것은 아니다. In one embodiment of the present invention, the neutralizing binding molecule of the present invention exhibits excellent binding ability and/or excellent neutralizing ability to the spike protein of SARS-CoV-2 (SARS-CoV-2). In another embodiment of the present invention, the neutralizing binding molecule of the present invention exhibits excellent binding and/or neutralizing ability to a mutant virus in which the spike protein of SARS-CoV-2 is mutated. In the present invention, the neutralizing binding molecule of the present invention is a binding molecule that binds to the receptor binding domain (RBD) region of the spike protein of SARS-CoV-2 and is screened as a binding molecule with neutralizing ability. can In the present invention, the neutralizing binding molecule of the present invention may exhibit excellent neutralizing ability against mutant viruses of other regions of the S protein other than the RBD region, but is not limited thereto.

세계보건기구(WHO)는 사스-코로나 바이러스-2를 유전자 염기서열 차이로 인한 아미노산 변화를 기준으로 6개 유형으로 분류하고 있다. 먼저 S, L 유형으로 분류되었다가 다시 L, V, G 유형으로 나뉘고 G가 GH와 GR로 나뉘면서 S, L, V, G, GH, GR 의 총 6개 유형으로 분류하고 있다. COVID-19 발생 초기에 중국 우한을 비롯한 아시아 지역에는 S와 V 유형이 유행하였고, 이후 대륙별로 서로 다른 유형이 발견되었다. 이 중 GH 유형이 전파력이 높게 나타날 가능성이 있다고 보고된바 있다. 국내의 경우 코로나바이러스 감염증 환자에서 채취한 유전자를 분류한 결과, 대부분은 유럽과 미국에서 유행한 G형의 변종인 GH형인 것으로 나타났고, 이유형은 바이러스 전파력이 높은 것으로 알려져 있다. 이 중 바이러스의 세포 내 침입 시 중요한 역할을 하는 스파이크 단백질의 614번 아미노산이 아스파트산 (D)에서 글리신 (G)으로 바뀐 G형의 바이러스는 3월 이후 유럽과 미국에서 급격히 증가해 현재는 거의 대부분 지역에서 나타나고 있다. 최근 보고된 바에 따르면 70여개 넘는 코로나바이러스 변이가 발생한 것으로 확인되었고, 전파력이 증가된 변이가 8개 (D614G 등), 중화항체를 회피하는 변이가 10개 (A841V 등), 혈장치료 효과가 낮은 변이 17개 (I472V 등)가 확인되었다.The World Health Organization (WHO) classifies SARS-Coronavirus-2 into six types based on amino acid changes due to differences in gene sequence. First, it was classified into S and L types, then again into L, V, and G types, and as G was divided into GH and GR, it is classified into a total of six types: S, L, V, G, GH, and GR. At the beginning of the COVID-19 outbreak, types S and V were prevalent in Asia including Wuhan, China, and after that, different types were discovered for each continent. Among them, it has been reported that the GH type has the potential to appear high in transmission power. In Korea, as a result of classifying the genes collected from patients with coronavirus infection, most of them were found to be the GH type, a variant of the G type prevalent in Europe and the United States. Among these, type G virus, in which amino acid 614 of the spike protein, which plays an important role in virus invasion, has been changed from aspartic acid (D) to glycine (G), has increased rapidly in Europe and the United States since March, and is now almost It appears in most areas. According to a recent report, more than 70 coronavirus mutations have been identified, 8 mutations with increased transmission power (D614G, etc.), 10 mutations that avoid neutralizing antibodies (A841V, etc.), mutations with low plasma treatment effect 17 (I472V, etc.) were identified.

본 발명에 있어, 본 발명의 중화 결합 분자는 SARS-CoV-2 바이러스 아미노산 변이 기준으로 S형(S 단백질의 614번 위치의 아미노산이 D), G형(S 단백질의 614번 위치의 아미노산이 G), V형 등의 균주(strain)에 중화능을 나타낼 수 있으나, 이 균주(strain)에 한정되는 것은 아니다. 상기 SARS-CoV-2 바이러스 S형의 일 예로는 BetaCoV/Korea/KCDC03/2020 균주가 있으나, 이 균주에 한정되는 것은 아니다. 상기 SARS-CoV-2 바이러스 G형의 일 예로는 hCoV-19/South Korea/KUMC17/2020 균주가 있으나, 이 균주에 한정되는 것은 아니다. 본 발명의 일 구체예에서, 본 발명의 중화 결합 분자는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질의 614번 아미노산 위치에서 D614G 변이가 일어난 변이 바이러스에도 우수한 중화능을 나타낸다. 일 실시예로, 본 발명의 중화 결합 분자는 사스-코로나바이러스-2(SARS-CoV-2)의 표면 단백질 (RBD)의 변이 단백질 A435S, F342L, G476S, K458R, N354D, V367F, V483A, 및 W436R에 대해 우수한 결합력을 나타낸다.In the present invention, the neutralizing binding molecule of the present invention is S-type (amino acid at position 614 of the S protein is D), G-type (the amino acid at position 614 of the S protein is G) based on the SARS-CoV-2 virus amino acid mutation. ), may exhibit neutralizing ability in strains such as V type, but is not limited to this strain. An example of the SARS-CoV-2 virus type S is the BetaCoV/Korea/KCDC03/2020 strain, but is not limited thereto. An example of the SARS-CoV-2 virus type G includes, but is not limited to, the hCoV-19/South Korea/KUMC17/2020 strain. In one embodiment of the present invention, the neutralizing binding molecule of the present invention exhibits excellent neutralizing ability even in a mutant virus in which D614G mutation occurs at amino acid position 614 of the spike protein of SARS-CoV-2 (SARS-CoV-2). In one embodiment, the neutralizing binding molecule of the present invention is SARS-coronavirus-2 (SARS-CoV-2) surface protein (RBD) mutant proteins A435S, F342L, G476S, K458R, N354D, V367F, V483A, and W436R It exhibits excellent bonding strength.

본 발명에 있어, 본 발명의 중화 결합 분자는 현재까지 단리된 사스-코로나바이러스-2 균주, 예를 들어 단리 일시와 장소를 알 수 없는 UNKNOWN-LR757996 균주(Strain), SARS-CoV-2/Hu/DP/Kng/19-027 균주; 2019년 12월 중국에서 단리된 Wuhan-Hu-1 균주; 2019년 12월 23일 최초로 중국에서 단리된 BetaCoV/Wuhan/IPBCAMS-WH-01/2019 균주; 2019년 12월 30일 중국에서 단리된 BetaCoV/Wuhan/IPBCAMS-WH-02/2019 균주, BetaCoV/Wuhan/IPBCAMS-WH-03/2019 균주, BetaCoV/Wuhan/IPBCAMS-WH-04/2019 균주, WIV02 균주, WIV04 균주, WIV05 균주, WIV06 균주, WIV07 균주; 2020년 1월 일본에서 단리된 2019-nCoV/Japan/TY/WK-521/2020 균주, 2019-nCoV/Japan/TY/WK-501/2020 균주, 2019-nCoV/Japan/TY/WK-012/2020 균주, 2019-nCoV/Japan/KY/V-029/2020 균주; 2020년 1월 대한민국에서 단리된 SNU01 균주; 대한민국에서 단리된 BetaCoV/Korea/KCDC03/2020 균주; 2020년 1월 1일 중국에서 단리된 BetaCoV/Wuhan/IPBCAMS-WH-05/2020 균주; 2020년 1월 2일 중국에서 단리된 2019-nCoV WHU02 균주, 2019-nCoV WHU01 균주; 2020년 1월 8일 중국에서 단리된 SARS-CoV-2/WH-09/human/2020/CHN 균주; 2020년 1월 10일 중국에서 단리된 2019-nCoV_HKU-SZ-002a_2020 균주; 2020년 1월 11일 중국에서 단리된 2019-nCoV_HKU-SZ-005b_2020 균주; 2020년 1월 17일 중국에서 단리된 SARS-CoV-2/Yunnan-01/human/2020/CHN 균주; 2020년 1월 19일 미국에서 단리된 2019-nCoV/USA-WA1/2020 균주; 2020년 1월 20일 중국에서 단리된 HZ-1 균주; 2020년 1월 21일 미국에서 단리된 2019-nCoV/USA-IL1/2020 균주; 2020년 1월 22일 미국에서 단리된 2019-nCoV/USA-CA2/2020 균주, 2019-nCoV/USA-AZ1/2020 균주; 2020년 1월 23일 미국에서 단리된 2019-nCoV/USA-CA1/2020 균주; 2020년 1월 25일 호주에서 단리된 Australia/VIC01/2020 균주; 2020년 1월 25일 미국에서 단리된 2019-nCoV/USA-WA1-F6/2020 균주, 2019-nCoV/USA-WA1-A12/2020 균주; 2020년 1월 27일 미국에서 단리된 2019-nCoV/USA-CA6/2020 균주; 2020년 1월 28일 미국에서 단리된 2019-nCoV/USA-IL2/2020 균주; 2020년 1월 29일 미국에서 단리된 2019-nCoV/USA-MA1/2020 균주, 2019-nCoV/USA-CA5/2020 균주, 2019-nCoV/USA-CA4/2020 균주, 2019-nCoV/USA-CA3/2020 균주; 2020년 1월 29일 핀란드에서 단리된 nCoV-FIN-29-Jan-2020 균주; 2020년 1월 29일 중국에서 단리된 SARS-CoV-2/IQTC02/human/2020/CHN 균주; 2020년 1월 31일 미국에서 단리된 2019-nCoV/USA-WI1/2020 균주; 2020년 1월 31일 타이완에서 단리된 SARS-CoV-2/NTU01/2020/TWN 균주; 2020년 2월 5일 타이완에서 단리된 SARS-CoV-2/NTU02/2020/TWN 균주; 2020년 2월 6일 미국에서 단리된 2019-nCoV/USA-CA7/2020 균주; 2020년 2월 7일 스웨덴에서 단리된 SARS-CoV-2/01/human/2020/SWE 균주; 2020년 2월 10일 미국에서 단리된 2019-nCoV/USA-CA8/2020 균주; 2020년 2월 11일 미국에서 단리된 2019-nCoV/USA-TX1/2020 균주; 2020년 2월 23일 미국에서 단리된 2019-nCoV/USA-CA9/2020 균주; 2020년 2월 28일 브라질에서 단리된 SARS-CoV-2/SP02/human/2020/BRA 균주; 단리 일시와 장소를 알 수 없는 UNKNOWN-LR757995, UNKNOWN-LR757997, UNKNOWN-LR757998, SARS-CoV-2/Hu/DP/Kng/19-020; 2020년 1월 일본에서 단리된 2019-nCoV/Japan/AI/I-004/2020; 2020년 1월 13일 네팔에서 단리된 SARS0CoV-2/61-TW/human/2020/ NPL; 2020년 2월 5일 중국에서 단리된 SARS-CoV-2/IQTC01/human/2020/CHN 균주; 대한민국에서 단리된 hCoV-19/South Korea/KUMC17/2020 균주와 향후 단리될 사스-코로나바이러스-2 균주에 대하여 중화 가능하나, 이들 균주에 한정되는 것은 아니다.In the present invention, the neutralizing binding molecule of the present invention is a SARS-coronavirus-2 strain isolated to date, for example, UNKNOWN-LR757996 strain (Strain), SARS-CoV-2/Hu of unknown date and place of isolation. /DP/Kng/19-027 strain; Wuhan-Hu-1 strain isolated from China in December 2019; BetaCoV/Wuhan/IPBCAMS-WH-01/2019 strain first isolated in China on December 23, 2019; BetaCoV/Wuhan/IPBCAMS-WH-02/2019 strain, BetaCoV/Wuhan/IPBCAMS-WH-03/2019 strain, BetaCoV/Wuhan/IPBCAMS-WH-04/2019 strain, WIV02 isolated on December 30, 2019 in China strain, WIV04 strain, WIV05 strain, WIV06 strain, WIV07 strain; 2019-nCoV/Japan/TY/WK-521/2020 strain isolated from Japan in January 2020, 2019-nCoV/Japan/TY/WK-501/2020 strain, 2019-nCoV/Japan/TY/WK-012/ 2020 strain, 2019-nCoV/Japan/KY/V-029/2020 strain; SNU01 strain isolated from Korea in January 2020; BetaCoV/Korea/KCDC03/2020 strain isolated from Korea; BetaCoV/Wuhan/IPBCAMS-WH-05/2020 strain isolated from China on January 1, 2020; 2019-nCoV WHU02 strain, 2019-nCoV WHU01 strain isolated on January 2, 2020 in China; SARS-CoV-2/WH-09/human/2020/CHN strain isolated from China on January 8, 2020; 2019-nCoV_HKU-SZ-002a_2020 strain isolated from China on January 10, 2020; 2019-nCoV_HKU-SZ-005b_2020 strain isolated from China on January 11, 2020; SARS-CoV-2/Yunnan-01/human/2020/CHN strain isolated from China on January 17, 2020; 2019-nCoV/USA-WA1/2020 strain isolated in the United States on January 19, 2020; HZ-1 strain isolated in China on January 20, 2020; 2019-nCoV/USA-IL1/2020 strain isolated in the United States on January 21, 2020; 2019-nCoV/USA-CA2/2020 strain, 2019-nCoV/USA-AZ1/2020 strain isolated in the United States on January 22, 2020; 2019-nCoV/USA-CA1/2020 strain isolated in the United States on January 23, 2020; Australia/VIC01/2020 strain isolated in Australia on 25 January 2020; 2019-nCoV/USA-WA1-F6/2020 strain, 2019-nCoV/USA-WA1-A12/2020 strain isolated in the United States on January 25, 2020; 2019-nCoV/USA-CA6/2020 strain isolated in the United States on January 27, 2020; 2019-nCoV/USA-IL2/2020 strain isolated in the United States on January 28, 2020; 2019-nCoV/USA-MA1/2020 strain, 2019-nCoV/USA-CA5/2020 strain, 2019-nCoV/USA-CA4/2020 strain, 2019-nCoV/USA-CA3 isolated in USA on January 29, 2020 /2020 strain; nCoV-FIN-29-Jan-2020 strain isolated on January 29, 2020 in Finland; SARS-CoV-2/IQTC02/human/2020/CHN strain isolated from China on January 29, 2020; 2019-nCoV/USA-WI1/2020 strain isolated in the United States on January 31, 2020; SARS-CoV-2/NTU01/2020/TWN strain isolated in Taiwan on January 31, 2020; SARS-CoV-2/NTU02/2020/TWN strain isolated on February 5, 2020 in Taiwan; 2019-nCoV/USA-CA7/2020 strain isolated in the United States on February 6, 2020; SARS-CoV-2/01/human/2020/SWE strain isolated on February 7, 2020 in Sweden; 2019-nCoV/USA-CA8/2020 strain isolated in the United States on February 10, 2020; 2019-nCoV/USA-TX1/2020 strain isolated in the United States on February 11, 2020; 2019-nCoV/USA-CA9/2020 strain isolated in the United States on February 23, 2020; SARS-CoV-2/SP02/human/2020/BRA strain isolated on February 28, 2020 in Brazil; UNKNOWN-LR757995, UNKNOWN-LR757997, UNKNOWN-LR757998, SARS-CoV-2/Hu/DP/Kng/19-020 of unknown date and place of isolation; 2019-nCoV/Japan/AI/I-004/2020 isolated from Japan in January 2020; SARS0CoV-2/61-TW/human/2020/NPL isolated from Nepal on January 13, 2020; SARS-CoV-2/IQTC01/human/2020/CHN strain isolated from China on February 5, 2020; It is possible to neutralize the hCoV-19/South Korea/KUMC17/2020 strain isolated in Korea and the SARS-coronavirus-2 strain to be isolated in the future, but is not limited to these strains.

(A) 중화 결합 분자(A) neutralizing binding molecule

본 발명에 있어, 본 발명의 중화 결합 분자는 사스-코로나바이러스-2(SARS-CoV-2) 표면의 스파이크 단백질(Spike protein, S protein)에 결합하는 중화 결합 분자일 수 있다.In the present invention, the neutralizing binding molecule of the present invention may be a neutralizing binding molecule that binds to a spike protein (S protein) on the surface of SARS-CoV-2.

본 발명의 중화 결합 분자는 하기 표 1의 결합 분자들로 이루어진 군으로부터 선택되는 어느 하나의 결합 분자일 수 있으며, 바람직하게는 하기 표 1의 결합 분자 No. 89 내지 No. 194, 및 No. 248로 이루어진 군으로부터 선택되는 어느 하나의 결합 분자일 수 있으며, 더욱 바람직하게는 하기 표 1의 No. 139 결합 분자일 수 있다. 하기 표 1에서 No.는 각 결합 분자의 번호를 의미한다.The neutralizing binding molecule of the present invention may be any one binding molecule selected from the group consisting of binding molecules shown in Table 1, preferably binding molecule No. 89 to No. 194, and No. 248 may be any one binding molecule selected from the group consisting of, more preferably No. 139 binding molecule. In Table 1 below, No. means the number of each binding molecule.

Figure pat00001
Figure pat00001

Figure pat00002
Figure pat00002

Figure pat00003
Figure pat00003

Figure pat00004
Figure pat00004

Figure pat00005
Figure pat00005

본 발명에 있어서, 본 발명에 따른 가변영역의 CDR은 Kabat 등에 의해 고안된 시스템에 따라 통상적인 방법으로 결정되었다(문헌 Kabat et al., Sequences of Proteins of Immunological Interest(5th), National Institutes of Health, Bethesda, MD. (1991) 참조). 본 발명에 사용된 CDR 넘버링은 Kabat 방법을 사용했으나, 이외에 IMGT 방법, Chothia 방법, AbM 방법 등 다른 방법에 따라 결정될 수 있다. 본 발명의 일 구체예에서, 상기 방법 중 어느 하나로 결정된 CDR을 포함하는 결합 분자도 본 발명에 포함된다. In the present invention, the CDRs of the variable region according to the present invention were determined by a conventional method according to the system devised by Kabat et al. (Kabat et al., Sequences of Proteins of Immunological Interest (5th), National Institutes of Health, Bethesda) , MD. (1991)). The CDR numbering used in the present invention uses the Kabat method, but may be determined according to other methods such as the IMGT method, the Chothia method, and the AbM method. In one embodiment of the present invention, a binding molecule comprising a CDR determined by any of the above methods is also included in the present invention.

본 발명에 있어, 본 발명의 중화 결합 분자는 하기 표 2의 결합 분자들로 이루어진 군으로부터 선택되는 어느 하나의 결합 분자일 수 있으며, 바람직하게는 하기 표 2의 결합 분자 No. 89 내지 No. 194, 및 No. 248로 이루어진 군으로부터 선택되는 어느 하나의 결합 분자일 수 있으며, 더욱 바람직하게는 No. 139 결합 분자일 수 있다. 하기 표 2에서 No.는 각 결합 분자의 번호를 의미한다.In the present invention, the neutralizing binding molecule of the present invention may be any one binding molecule selected from the group consisting of binding molecules shown in Table 2, preferably binding molecule No. 89 to No. 194, and No. 248 may be any one binding molecule selected from the group consisting of, more preferably No. 139 binding molecule. In Table 2 below, No. means the number of each binding molecule.

Figure pat00006
Figure pat00006

Figure pat00007
Figure pat00007

Figure pat00008
Figure pat00008

Figure pat00009
Figure pat00009

Figure pat00010
Figure pat00010

Figure pat00011
Figure pat00011

Figure pat00012
Figure pat00012

Figure pat00013
Figure pat00013

Figure pat00014
Figure pat00014

Figure pat00015
Figure pat00015

Figure pat00016
Figure pat00016

Figure pat00017
Figure pat00017

Figure pat00018
Figure pat00018

또한, 본 발명의 중화 결합 분자는 하기 표 3의 결합 분자들로 이루어진 군으로부터 선택되는 어느 하나의 결합 분자일 수 있으며, 바람직하게는 하기 표 3의 No. 322 또는 No. 343 결합 분자일 수 있으며, 더욱 바람직하게는 No. 322 결합 분자일 수 있다. 하기 표 3에서 No.는 각 결합 분자의 번호를 의미한다.In addition, the neutralizing binding molecule of the present invention may be any one binding molecule selected from the group consisting of binding molecules shown in Table 3, preferably No. 322 or No. 343 binding molecule, more preferably No. 322 binding molecule. In Table 3 below, No. means the number of each binding molecule.

Figure pat00019
Figure pat00019

Figure pat00020
Figure pat00020

Figure pat00021
Figure pat00021

Figure pat00022
Figure pat00022

또한, 본 발명의 중화 결합 분자는 하기 표 4의 결합 분자들로 이루어진 군으로부터 선택되는 어느 하나의 결합 분자일 수 있으며, 바람직하게는 하기 표 4의 No. 322 또는 No. 343 결합 분자일 수 있으며, 더욱 바람직하게는 No. 322 결합 분자일 수 있다. 하기 표 4에서 No.는 각 결합 분자의 번호를 의미한다.In addition, the neutralizing binding molecule of the present invention may be any one binding molecule selected from the group consisting of binding molecules shown in Table 4, preferably No. 322 or No. 343 binding molecule, more preferably No. 322 binding molecule. In Table 4 below, No. means the number of each binding molecule.

Figure pat00023
Figure pat00023

Figure pat00024
Figure pat00024

Figure pat00025
Figure pat00025

Figure pat00026
Figure pat00026

Figure pat00027
Figure pat00027

Figure pat00028
Figure pat00028

Figure pat00029
Figure pat00029

Figure pat00030
Figure pat00030

Figure pat00031
Figure pat00031

Figure pat00032
Figure pat00032

본 발명에 있어, 본 발명의 중화 결합 분자는 scFv 절편, scFv-Fc 절편, Fab 절편, Fv 절편, 디아바디(diabody), 키메라 항체, 인간화 항체 또는 인간 항체일 수 있으나, 이에 한정되지 않는다. 본 발명의 중화 결합 분자는 SARS-CoV-2 S 단백질에 결합하는 scFv-Fc일 수 있다. 또한, 본 발명의 다른 일 실시예에 따르면, SARS-CoV-2 S 단백질에 결합하는 완전한 인간 항체(Full IgG)를 제공할 수 있다.In the present invention, the neutralizing binding molecule of the present invention may be an scFv fragment, an scFv-Fc fragment, a Fab fragment, an Fv fragment, a diabody, a chimeric antibody, a humanized antibody, or a human antibody, but is not limited thereto. The neutralizing binding molecule of the present invention may be an scFv-Fc that binds to the SARS-CoV-2 S protein. In addition, according to another embodiment of the present invention, it is possible to provide a fully human antibody (Full IgG) that binds to the SARS-CoV-2 S protein.

본 발명의 일 구체예에서, 본 발명의 중화 결합 분자는 LC CDR1, LC CDR2 및 LC CDR3을 포함하는 경쇄 가변 영역, 및 HC CDR1, HC CDR2 및 HC CDR3을 포함하는 중쇄 가변 영역을 포함하며,In one embodiment of the present invention, a neutralizing binding molecule of the present invention comprises a light chain variable region comprising LC CDR1, LC CDR2 and LC CDR3, and a heavy chain variable region comprising HC CDR1, HC CDR2 and HC CDR3,

상기 LC CDR1은 서열 SGX1X2SNIGX3NX4X5S를 포함하고, 여기서 X1은 S, G 또는 R이고, X2는 S, N 또는 T이고, X3은 N, D 또는 K이고, X4는 Y 또는 F이고, X5는 V 또는 I이고,said LC CDR1 comprises the sequence SGX 1 X 2 SNIGX 3 NX 4 X 5 S, wherein X 1 is S, G or R, X 2 is S, N or T, and X 3 is N, D or K , X 4 is Y or F, X 5 is V or I,

상기 LC CDR2는 서열 DNX6KRPS를 포함하고, 여기서 X6은 N 또는 D이고,wherein said LC CDR2 comprises the sequence DNX 6 KRPS, wherein X 6 is N or D;

상기 LC CDR3은 서열 GTWDX7X8LSX9X10X11을 포함하고, 여기서 X7은 S 또는 N이고, X8은 S 또는 N이고, X9는 A 또는 G이고, X10은 G 또는 V이고, X11은 V 또는 R이고,wherein said LC CDR3 comprises the sequence GTWDX 7 X 8 LSX 9 X 10 X 11 , wherein X 7 is S or N, X 8 is S or N, X 9 is A or G, and X 10 is G or V and X 11 is V or R,

상기 HC CDR1은 서열 TSGX12GVX13을 포함하고, 여기서 X12는 M 또는 V이고, X13은 G 또는 S이고,said HC CDR1 comprises the sequence TSGX 12 GVX 13 , wherein X 12 is M or V, X 13 is G or S,

상기 HC CDR2는 서열 LIDWDDNKYX14TTSLKT를 포함하고, 여기서 X14는 Y 또는 H이고,wherein said HC CDR2 comprises the sequence LIDWDDNKYX 14 TTSLKT, wherein X 14 is Y or H;

상기 HC CDR3은 서열 IPGFLRYRNRYYYYGX15DV를 포함하고, 여기서 X15는 M 또는 V인 결합 분자일 수 있다.Said HC CDR3 may be a binding molecule comprising the sequence IPGFLRYRNRYYYYGX 15 DV, wherein X 15 is M or V.

또한, 본 발명의 일 구체예에서, 본 발명의 중화 결합 분자는 LC CDR1, LC CDR2 및 LC CDR3을 포함하는 경쇄 가변 영역, 및 HC CDR1, HC CDR2 및 HC CDR3을 포함하는 중쇄 가변 영역을 포함하며, Further, in one embodiment of the present invention, the neutralizing binding molecule of the present invention comprises a light chain variable region comprising LC CDR1, LC CDR2 and LC CDR3, and a heavy chain variable region comprising HC CDR1, HC CDR2 and HC CDR3, ,

상기 LC CDR1은 서열 RASQSISSYLN을 포함하고, wherein said LC CDR1 comprises the sequence RASQSISSYLN,

상기 LC CDR2는 서열 AASSLQS를 포함하고, wherein the LC CDR2 comprises the sequence AASSLQS,

상기 LC CDR3은 서열 QQSYSTPLT를 포함하고, wherein said LC CDR3 comprises the sequence QQSYSTPLT,

상기 HC CDR1은 서열 SNYMX16을 포함하고, 여기서 X16은 T 또는 S이고,wherein said HC CDR1 comprises the sequence SNYMX 16 , wherein X 16 is T or S;

상기 HC CDR2는 서열 X17IYPGGSTX18X19ADSVX20G를 포함하고, 여기서 X17은 I 또는 V이고, X18은 Y 또는 F이고, X19는 Y 또는 F이고, X20은 K또는 Q이고,wherein said HC CDR2 comprises the sequence X 17 IYPGGSTX 18 X 19 ADSVX 20 G, wherein X 17 is I or V, X 18 is Y or F, X 19 is Y or F, and X 20 is K or Q ,

상기 HC CDR3은 서열 DLPLTGTTLDY 또는 SYDFLTDYTDAFDI를 포함하는 결합 분자일 수 있다.The HC CDR3 may be a binding molecule comprising the sequence DLPLTGTTLDY or SYDFLTDYTDAFDI.

본 발명의 일 구체예에서, 본 발명의 중화 결합 분자는 서열번호: 829의 CDR1 영역, 서열번호: 830의 CDR2 영역, 및 서열번호: 831의 CDR3 영역을 포함하는 경쇄 가변영역; 및 서열번호: 832의 CDR1 영역, 서열번호: 833의 CDR2 영역, 및 서열번호: 834의 CDR3영역을 포함하는 중쇄 가변영역을 포함할 수 있다.In one embodiment of the present invention, the neutralizing binding molecule of the present invention comprises a light chain variable region comprising a CDR1 region of SEQ ID NO: 829, a CDR2 region of SEQ ID NO: 830, and a CDR3 region of SEQ ID NO: 831; and a heavy chain variable region comprising a CDR1 region of SEQ ID NO: 832, a CDR2 region of SEQ ID NO: 833, and a CDR3 region of SEQ ID NO: 834.

또한, 본 발명의 일 구체예에서 본 발명의 중화 결합 분자는 서열번호: 2507의 CDR1 영역, 서열번호: 2508의 CDR2 영역, 및 서열번호: 2509의 CDR3 영역을 포함하는 경쇄 가변영역; 및 서열번호: 2510의 CDR1 영역, 서열번호: 2511의 CDR2 영역, 및 서열번호: 2512의 CDR3 영역을 포함하는 중쇄 가변영역을 포함할 수 있다.Further, in one embodiment of the present invention, the neutralizing binding molecule of the present invention comprises a light chain variable region comprising a CDR1 region of SEQ ID NO: 2507, a CDR2 region of SEQ ID NO: 2508, and a CDR3 region of SEQ ID NO: 2509; and a heavy chain variable region comprising a CDR1 region of SEQ ID NO: 2510, a CDR2 region of SEQ ID NO: 2511, and a CDR3 region of SEQ ID NO: 2512.

본 발명의 일 구체예에서, 상기 중화 결합 분자는 서열번호: 2017의 폴리펩티드 서열의 경쇄 가변영역; 및 서열번호: 2018의 폴리펩티드 서열의 중쇄 가변영역을 포함하는 결합 분자와 80% 내지 99%, 바람직하게는 85 내지 99%, 보다 바람직하게는 90 내지 99% 동일한 서열을 포함하는 결합 분자일 수 있다.In one embodiment of the present invention, the neutralizing binding molecule comprises a light chain variable region of the polypeptide sequence of SEQ ID NO: 2017; and 80% to 99%, preferably 85 to 99%, more preferably 90 to 99% identical to the binding molecule comprising the heavy chain variable region of the polypeptide sequence of SEQ ID NO: 2018. It may be a binding molecule comprising a sequence .

또한, 본 발명의 일 구체예에서, 상기 중화 결합 분자는 서열번호: 3523의 폴리펩티드 서열의 경쇄 가변영역; 및 서열번호: 3524의 폴리펩티드 서열의 중쇄 가변영역을 포함하는 결합 분자와 80% 내지 99%, 바람직하게는 85 내지 99%, 보다 바람직하게는 90 내지 99% 동일한 서열을 포함하는 결합 분자일 수 있다.Also, in one embodiment of the present invention, the neutralizing binding molecule comprises a light chain variable region of the polypeptide sequence of SEQ ID NO: 3523; and 80% to 99%, preferably 85 to 99%, more preferably 90 to 99% identical to the binding molecule comprising the heavy chain variable region of the polypeptide sequence of SEQ ID NO: 3524. .

본 발명의 일 구체예에서, 상기 중화 결합 분자는 서열번호: 2017의 폴리펩티드 서열의 경쇄 가변영역; 및 서열번호: 2018의 폴리펩티드 서열의 중쇄 가변영역을 포함할 수 있다.In one embodiment of the present invention, the neutralizing binding molecule comprises a light chain variable region of the polypeptide sequence of SEQ ID NO: 2017; and a heavy chain variable region of the polypeptide sequence of SEQ ID NO: 2018.

또한, 본 발명의 일 구체예에서, 상기 중화 결합 분자는 서열번호: 3523의 폴리펩티드 서열의 경쇄 가변영역; 및 서열번호: 3524의 폴리펩티드 서열의 중쇄 가변영역을 포함할 수 있다.Also, in one embodiment of the present invention, the neutralizing binding molecule comprises a light chain variable region of the polypeptide sequence of SEQ ID NO: 3523; and a heavy chain variable region of the polypeptide sequence of SEQ ID NO: 3524.

본 명세서에서 용어 '항체'는 최대한 넓은 의미로 사용되며, 구체적으로 온전한(intact) 단일클론 항체, 다클론 항체, 2종 이상의 온전한 항체로부터 형성된 다중특이성 항체(예를 들어, 이중특이성 항체), 및 목적하는 생물학적 활성을 나타내는 항체 단편을 포함한다. 항체는 특이적인 항원을 인식하고 결합할 수 있는 면역계에 의하여 생성되는 단백질이다. 그 구조적인 면에서, 항체는 통상적으로 4개의 아미노산 쇄(2개의 중쇄 및 2개의 경쇄)로 이루어진 Y-형상의 단백질을 가진다. 각각의 항체는 주로 가변 영역 및 불변 영역의 2개의 영역을 가진다. Y의 팔의 말단 부분에 위치한 가변 영역은 표적 항원에 결합하고 상호작용한다. 상기 가변 영역은 특정 항원 상의 특이적 결합 부위를 인식하고 결합하는 상보성 결정 영역(CDR)을 포함한다. Y의 꼬리 부분에 위치한 불변 영역은 면역계에 의하여 인식되고 상호작용한다. 표적 항원은 일반적으로 다수의 항체 상의 CDR에 의하여 인식되는, 에피토프라고 하는 다수의 결합 부위를 가지고 있다. 상이한 에피토프에 특이적으로 결합하는 각각의 항체는 상이한 구조를 가진다. 그러므로 한 항원은 하나 이상의 상응하는 항체를 가질 수 있다.As used herein, the term 'antibody' is used in the broadest sense, specifically, an intact monoclonal antibody, a polyclonal antibody, a multispecific antibody formed from two or more intact antibodies (eg, a bispecific antibody), and antibody fragments exhibiting the desired biological activity. Antibodies are proteins produced by the immune system that are capable of recognizing and binding to specific antigens. In terms of their structure, antibodies usually have a Y-shaped protein consisting of four amino acid chains (two heavy chains and two light chains). Each antibody mainly has two regions: a variable region and a constant region. The variable region located in the distal portion of the arm of Y binds and interacts with the target antigen. The variable region comprises a complementarity determining region (CDR) that recognizes and binds a specific binding site on a specific antigen. The constant region located at the tail of Y is recognized and interacted with by the immune system. Target antigens have multiple binding sites, called epitopes, which are generally recognized by CDRs on multiple antibodies. Each antibody that specifically binds to a different epitope has a different structure. Thus, an antigen may have more than one corresponding antibody.

본 발명에 있어, 본 발명에 따른 결합 분자는 상기 결합 분자의 기능적 변이체를 포함할 수 있다. 본 발명의 변이체는 SARS-CoV-2 또는 이것의 S 단백질에 특이적으로 결합하기 위해 본 발명의 결합 분자와 경쟁할 수 있다. 본 발명에 있어, SARS-CoV-2에 중화 능력을 보유한다면 본 발명의 결합 분자의 기능적 변이체로 간주된다. 본 발명에 있어, 상기 기능적 변이체는 1차 구조적 서열이 실질적으로 유사한 유도체를 포함하지만, 이에 제한되는 것은 아니다. 예를 들면, 상기 기능적 변이체는 생체외(in vitro) 또는 생체내(in vivo) 변형, 화학약품 및/또는 생화학 약품에 의한 변형을 포함한다. 본 발명의 일 구체예에 있어, 상기 기능적 변이체는 본원 발명의 부모 단일클론 항체에서는 발견되지 않는다. 이와 같은 변형으로는 예를 들어 아세틸화, 아실화, 뉴클레오티드 또는 뉴클레오티드 유도체의 공유 결합, 지질 또는 지질 유도체의 공유 결합, 가교, 이황화 결합 형성, 글리코실화, 수산화, 메틸화, 산화, 페길화, 단백질 분해 및 인산화 등이 포함된다. 본 발명에 있어, 상기 기능적 변이체는 선택적으로 부모 항체의 아미노산 서열과 비교하여 하나 이상의 아미노산의 치환, 삽입, 결실 또는 그들의 조합을 함유하는 아미노산 서열을 포함할 수 있다. 더욱이, 상기 기능적 변이체는 아미노 말단 또는 카르복시 말단 중 하나 또는 모두에서 아미노산 서열의 절단체(truncated form)를 포함할 수 있다. 본 발명에 있어, 본 발명의 기능적 변이체는 본 발명의 부모 항체와 비교하여 동일하거나 다르거나, 더 높거나 낮은 결합 친화력을 가질 수 있지만, 여전히 SARS-CoV-2 또는 이것의 S 단백질에 결합할 수 있다. 일 예로, 골격구조, 초가변(Hypervariable) 영역, 특히 경쇄 또는 중쇄의 상보성 결정 영역(Complementarity-determining region, CDR)을 포함하나 이에 한정되지 않는 가변 영역의 아미노산 서열이 변형될 수 있다. 일반적으로 경쇄 또는 중쇄 영역은 3개의 CDR 영역을 포함하는, 3개의 초가변 영역 및 더욱 보존된 영역, 즉 골격 영역(FR)을 포함한다. 일반적으로 초가변 영역은 CDR로부터의 아미노산 잔기와 초가변 루프로부터의 아미노산 잔기를 포함한다. 본 발명의 범위에 속하는 기능적 변이체는 본 명세서의 부모 항체와 약 50%~99%, 약 60%~99%, 약 80%~99%, 약 90%~99%, 약 95%~99%, 또는 약 97%~99% 아미노산 서열 동질성을 가질 수 있다. 본 발명에 있어, 비교될 아미노산 서열을 최적으로 배열하고 유사하거나 또는 동일한 아미노산 잔기를 정의하기 위해 컴퓨터 알고리즘 중 당업자에게 알려진 Gap 또는 Bestfit를 사용할 수 있다. 본 발명에 있어, 상기 기능적 변이체는 부모 항체 또는 그것의 일부를 PCR 방법, 올리고머 뉴클레오티드를 이용한 돌연변이 생성 및 부분 돌연변이 생성을 포함하는 공지의 일반 분자생물학적 방법에 의해 변화시키거나 유기합성 방법으로 얻을 수 있으나 이에 제한되는 것은 아니다. In the present invention, the binding molecule according to the present invention may include a functional variant of the binding molecule. A variant of the invention may compete with a binding molecule of the invention for specific binding to SARS-CoV-2 or its S protein. In the present invention, it is regarded as a functional variant of the binding molecule of the present invention if it has the ability to neutralize SARS-CoV-2. In the present invention, the functional variant includes, but is not limited to, a derivative having a substantially similar primary structural sequence. For example, the functional variant includes in vitro or in vivo modification, modification by chemical and/or biochemical agents. In one embodiment of the present invention, the functional variant is not found in the parental monoclonal antibody of the present invention. Such modifications include, for example, acetylation, acylation, covalent bonding of nucleotides or nucleotide derivatives, covalent bonding of lipids or lipid derivatives, crosslinking, disulfide bond formation, glycosylation, hydroxylation, methylation, oxidation, pegylation, proteolysis. and phosphorylation. In the present invention, the functional variant may optionally comprise an amino acid sequence containing one or more amino acid substitutions, insertions, deletions or combinations thereof compared to the amino acid sequence of the parent antibody. Moreover, the functional variant may comprise a truncated form of the amino acid sequence at one or both of the amino terminus or the carboxy terminus. In the present invention, functional variants of the present invention may have the same, different, higher or lower binding affinity compared to the parent antibody of the present invention, but still be capable of binding to SARS-CoV-2 or its S protein. there is. As an example, the amino acid sequence of a variable region including, but not limited to, a framework structure, a hypervariable region, in particular, a complementarity-determining region (CDR) of a light or heavy chain may be modified. Generally a light or heavy chain region comprises three hypervariable regions, comprising three CDR regions, and a more conserved region, namely a framework region (FR). In general, a hypervariable region comprises amino acid residues from a CDR and amino acid residues from a hypervariable loop. Functional variants within the scope of the present invention include about 50%-99%, about 60%-99%, about 80%-99%, about 90%-99%, about 95%-99%, or about 97%-99% amino acid sequence identity. In the present invention, Gap or Bestfit known to those skilled in the art among computer algorithms may be used to optimally align amino acid sequences to be compared and to define similar or identical amino acid residues. In the present invention, the functional variant may be obtained by changing the parent antibody or a part thereof by a known general molecular biological method including PCR method, mutagenesis using oligomeric nucleotides and partial mutagenesis, or by organic synthesis method. However, the present invention is not limited thereto.

또한, 본 발명의 일 구체예에서, 상기 결합 분자는 추가적으로 하나 이상의 태그가 결합된 이뮤노컨쥬게이트일 수 있으며, 예를 들어, 상기 결합 분자에 약물이 추가로 부착된 이뮤노컨쥬게이트일 수 있다. 즉, 본 발명에 따른 결합 분자는 약물이 결합된 항체-약물 접합체(antibody-drug conjugate; ADC)의 형태로 사용될 수 있다. 약물을 국소 전달하기 위해 항체-약물 접합체(ADC), 즉 면역접합체를 사용하게 되면 약물 모이어티를 감염된 세포에 표적화 전달할 수 있는 반면, 접합시키지 않은 채로 투여하게 되면, 정상 세포에 대해서도 허용될 수 없는 수준의 독성이 야기될 수 있다. 상기 ADC 형태는 약물-연결성 및 약물-방출성 뿐만 아니라 폴리클로날(polyclonal) 및 모노클로날(monoclonal) 항체(mAb)의 선택성을 높임으로써 약물의 최대 효능과 최소 독성을 개선할 수 있다.Also, in one embodiment of the present invention, the binding molecule may be an immunoconjugate to which one or more tags are additionally bound, for example, an immunoconjugate to which a drug is further attached to the binding molecule. . That is, the binding molecule according to the present invention may be used in the form of an antibody-drug conjugate (ADC) to which a drug is bound. The use of antibody-drug conjugates (ADCs), i.e. immunoconjugates, for local delivery of drugs allows for targeted delivery of drug moieties to infected cells, whereas unconjugated administration is unacceptable for normal cells as well. A level of toxicity may be caused. The ADC form can improve the maximum efficacy and minimum toxicity of the drug by increasing the drug-connectivity and drug-releasing properties as well as the selectivity of polyclonal and monoclonal antibodies (mAbs).

약물 모이어티를 항체에 부착시키는, 예를 들어 공유 결합을 통하여 연결시키는 통상적인 수단으로는, 일반적으로 약물 모이어티가 항체 상의 수많은 부위에 부착되는 불균질한 분자 혼합물이 유발된다. 예를 들어, 세포독성 약물을 항체의 수많은 리신 잔기를 통하여 항체와 접합시켜 불균질한 항체-약물 접합체 혼합물을 생성시킬 수 있다. 반응 조건에 따라서, 이러한 불균질한 혼합물은 전형적으로, 약물 모이어티에 부착된 항체 분포도가 0 내지 약 8 이상이다. 또한, 특별한 정수 비의 약물 모이어티 대 항체를 수반한 접합체의 각 아군은, 약물 모이어티가 항체 상의 각종 부위에 부착되는 잠재적으로 불균질한 혼합물이다. 일 예로, 링커 시약 및 약물-링커 중간체와의 반응성은 pH, 농도, 염 농도 및 조용매와 같은 요인들에 의해 좌우된다.Conventional means of attaching drug moieties to antibodies, for example linking them via covalent bonds, generally result in heterogeneous molecular mixtures in which drug moieties are attached to numerous sites on the antibody. For example, a cytotoxic drug can be conjugated with the antibody through the numerous lysine residues of the antibody to produce a heterogeneous mixture of antibody-drug conjugates. Depending on the reaction conditions, such heterogeneous mixtures typically have a distribution of 0 to about 8 or greater of antibody attached to the drug moiety. In addition, each subgroup of conjugates with a particular integer ratio of drug moieties to antibody is a potentially heterogeneous mixture in which drug moieties are attached to various sites on the antibody. In one example, the reactivity of linker reagents and drug-linker intermediates depends on factors such as pH, concentration, salt concentration and cosolvent.

본 발명의 일 구체예에서, 본 발명의 (A) 중화 결합 분자의 농도는 본 발명에 따른 안정한 약제학적 제제의 안정성 및 점도에 악영향을 실질적으로 미치지 않는 범위 내에서 자유롭게 조절할 수 있다. 본 발명의 일 구현예에서, 중화 결합 분자의 농도는 1 내지 240 mg/ml일 수 있다. 본 발명의 다른 구현예에서, 중화 결합 분자의 농도는 1 내지 230 mg/ml일 수 있다. 본 발명의 다른 구현예에서, 중화 결합 분자의 농도는 1 내지 220 mg/ml일 수 있다. 본 발명의 다른 구현예에서, 중화 결합 분자의 농도는 1 내지 210 mg/ml일 수 있다. 본 발명의 다른 구현예에서, 중화 결합 분자의 농도는 1 내지 200 mg/ml일 수 있다. In one embodiment of the present invention, the concentration of (A) neutralizing binding molecule of the present invention can be freely adjusted within a range that does not substantially adversely affect the stability and viscosity of the stable pharmaceutical preparation according to the present invention. In one embodiment of the present invention, the concentration of the neutralizing binding molecule may be 1 to 240 mg/ml. In another embodiment of the invention, the concentration of the neutralizing binding molecule may be 1 to 230 mg/ml. In another embodiment of the invention, the concentration of the neutralizing binding molecule may be 1 to 220 mg/ml. In another embodiment of the invention, the concentration of the neutralizing binding molecule may be 1 to 210 mg/ml. In another embodiment of the invention, the concentration of the neutralizing binding molecule may be between 1 and 200 mg/ml.

본 발명의 일 구현예에서, 중화 결합 분자의 농도는 5 내지 240 mg/ml일 수 있다. 본 발명의 다른 구현예에서, 중화 결합 분자의 농도는 5 내지 230 mg/ml일 수 있다. 본 발명의 다른 구현예에서, 중화 결합 분자의 농도는 5 내지 220 mg/ml일 수 있다. 본 발명의 다른 구현예에서, 중화 결합 분자의 농도는 5 내지 210 mg/ml일 수 있다. 본 발명의 다른 구현예에서, 중화 결합 분자의 농도는 5 내지 200 mg/ml일 수 있다. In one embodiment of the present invention, the concentration of the neutralizing binding molecule may be 5 to 240 mg/ml. In another embodiment of the invention, the concentration of the neutralizing binding molecule may be between 5 and 230 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 5 to 220 mg/ml. In another embodiment of the invention, the concentration of the neutralizing binding molecule may be between 5 and 210 mg/ml. In another embodiment of the invention, the concentration of the neutralizing binding molecule may be 5 to 200 mg/ml.

또한, 본 발명의 일 구현예에서, 중화 결합 분자의 농도는 10 내지 240 mg/ml일 수 있다. 본 발명의 다른 구현예에서, 중화 결합 분자의 농도는 10 내지 230 mg/ml일 수 있다. 본 발명의 다른 구현예에서, 중화 결합 분자의 농도는 10 내지 220 mg/ml일 수 있다. 본 발명의 다른 구현예에서, 중화 결합 분자의 농도는 10 내지 210 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 10 내지 200 mg/ml일 수 있다. Also, in one embodiment of the present invention, the concentration of the neutralizing binding molecule may be 10-240 mg/ml. In another embodiment of the invention, the concentration of the neutralizing binding molecule may be between 10 and 230 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 10-220 mg/ml. In another embodiment of the invention, the concentration of the neutralizing binding molecule may be between 10 and 210 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 10 and 200 mg/ml.

또한, 본 발명의 일 구현예에서, 중화 결합 분자의 농도는 20 내지 240 mg/ml일 수 있다. 본 발명의 다른 구현예에서, 중화 결합 분자의 농도는 20 내지 230 mg/ml일 수 있다. 본 발명의 다른 구현예에서, 중화 결합 분자의 농도는 20 내지 220 mg/ml일 수 있다. 본 발명의 다른 구현예에서, 중화 결합 분자의 농도는 20 내지 210 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 20 내지 200 mg/ml일 수 있다. Also, in one embodiment of the present invention, the concentration of the neutralizing binding molecule may be 20 to 240 mg/ml. In another embodiment of the invention, the concentration of the neutralizing binding molecule may be between 20 and 230 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 20 and 220 mg/ml. In another embodiment of the invention, the concentration of the neutralizing binding molecule may be between 20 and 210 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 20 and 200 mg/ml.

또한, 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 30 내지 240 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 30 내지 230 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 30 내지 220 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 30 내지 210 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 30 내지 200 mg/ml일 수 있다. Also, in another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 30 to 240 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 30 and 230 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 30 and 220 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 30 and 210 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 30 and 200 mg/ml.

또한, 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 40 내지 240 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 40 내지 230 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 40 내지 220 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 40 내지 210 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 40 내지 200 mg/ml일 수 있다. Also, in another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 40 to 240 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 40 and 230 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 40 and 220 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 40 and 210 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 40 and 200 mg/ml.

또한, 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 1 내지 100 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 1 내지 90 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 1 내지 80 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 1 내지 70 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 1 내지 60 mg/ml일 수 있다. Also, in another embodiment of the present invention, the concentration of the neutralizing binding molecule may be from 1 to 100 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 1 to 90 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 1 to 80 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 1 and 70 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 1 and 60 mg/ml.

본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 5 내지 100 mg/ml일 수 있다. 본 발명의 또 다른 구현예에 따르면, 중화 결합 분자의 농도는 5 내지 90 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 5 내지 80 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 5 내지 70 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 5 내지 60 mg/ml일 수 있다.In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 5 and 100 mg/ml. According to another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 5 to 90 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 5 to 80 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 5 to 70 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 5 and 60 mg/ml.

본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 10 내지 100 mg/ml일 수 있다. 본 발명의 또 다른 구현예에 따르면, 중화 결합 분자의 농도는 10 내지 90 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 10 내지 80 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 10 내지 70 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 10 내지 60 mg/ml일 수 있다.In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 10 and 100 mg/ml. According to another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 10 to 90 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 10 and 80 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 10 and 70 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 10 and 60 mg/ml.

본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 20 내지 100 mg/ml일 수 있다. 본 발명의 또 다른 구현예에 따르면, 중화 결합 분자의 농도는 20 내지 90 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 20 내지 80 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 20 내지 70 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 20 내지 60 mg/ml일 수 있다.In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 20 and 100 mg/ml. According to another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 20 to 90 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 20 and 80 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 20 and 70 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 20 and 60 mg/ml.

본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 30 내지 100 mg/ml일 수 있다. 본 발명의 또 다른 구현예에 따르면, 중화 결합 분자의 농도는 30 내지 90 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 30 내지 80 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 30 내지 70 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 30 내지 60 mg/ml일 수 있다.In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 30 and 100 mg/ml. According to another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 30 to 90 mg/ml. In another embodiment of the invention, the concentration of the neutralizing binding molecule may be between 30 and 80 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 30 and 70 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 30 and 60 mg/ml.

본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 40 내지 100 mg/ml일 수 있다. 본 발명의 또 다른 구현예에 따르면, 중화 결합 분자의 농도는 40 내지 90 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 40 내지 80 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 40 내지 70 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 40 내지 60 mg/ml일 수 있다.In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 40 and 100 mg/ml. According to another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 40 to 90 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 40 to 80 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 40 to 70 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 40 and 60 mg/ml.

본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 50 내지 100 mg/ml일 수 있다. 본 발명의 또 다른 구현예에 따르면, 중화 결합 분자의 농도는 50 내지 90 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 50 내지 80 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 50 내지 70 mg/ml일 수 있다. 본 발명의 또 다른 구현예에서, 중화 결합 분자의 농도는 50 내지 60 mg/ml일 수 있다.In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 50 and 100 mg/ml. According to another embodiment of the present invention, the concentration of the neutralizing binding molecule may be 50 to 90 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 50 and 80 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 50 and 70 mg/ml. In another embodiment of the present invention, the concentration of the neutralizing binding molecule may be between 50 and 60 mg/ml.

(B) 완충제(B) buffer

본 발명에 있어, 본 발명에 따른 완충제는 산이나 알칼리에 의한 pH의 변화를 최소화시키는 중화성 물질이며, 상기 완충제는 i) 히스티딘, 히스티딘염 또는 이들의 혼합물,ii) 아세테이트(acetate), iii) 시트레이트(citrate), iv) 숙시네이트(succinate), v) 포스페이트(phosphate), 또는 vi) 글루코네이트(gluconate)를 포함할 수 있으나, 이에 한정되는 것은 아니다. In the present invention, the buffer according to the present invention is a neutralizing material that minimizes changes in pH due to acid or alkali, and the buffer is i) histidine, histidine salt or a mixture thereof, ii) acetate, iii) citrate, iv) succinate, v) phosphate, or vi) gluconate, but is not limited thereto.

본 발명의 일 구현예에서, 상기 히스티딘염은 히스티딘 클로라이드, 히스티딘 아세테이트, 히스티딘 포스페이트, 히스티딘 설페이트 등을 포함할 수 있다. 본 발명에 있어, 완충제로 히스티딘을 포함하는 것이, pH 조절 및 안정성 측면에서 바람직할 수 있다.In one embodiment of the present invention, the histidine salt may include histidine chloride, histidine acetate, histidine phosphate, histidine sulfate, and the like. In the present invention, it may be preferable in terms of pH control and stability to include histidine as a buffer.

본 발명의 일 구현예에서, 상기 완충제의 함량은 본 발명에 따른 약제학적 제제의 안정성 및 점도에 악영향을 실질적으로 미치지 않는 범위 내에서 자유롭게 조절할 수 있다. 본 발명의 일 구현예에서, 완충제의 함량은 1 내지 100 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 1 내지 90 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 1 내지 80 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 1 내지 70 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 1 내지 60 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 1 내지 50 mM일 수 있다.In one embodiment of the present invention, the content of the buffer can be freely adjusted within a range that does not substantially adversely affect the stability and viscosity of the pharmaceutical formulation according to the present invention. In one embodiment of the present invention, the content of the buffer may be 1 to 100 mM. In another embodiment of the present invention, the content of the buffer may be 1 to 90 mM. In another embodiment of the present invention, the content of the buffer may be 1 to 80 mM. In another embodiment of the present invention, the content of the buffer may be 1 to 70 mM. In another embodiment of the present invention, the content of the buffer may be 1 to 60 mM. In another embodiment of the present invention, the content of the buffer may be 1 to 50 mM.

본 발명의 일 구현예에서, 완충제의 함량은 2 내지 100 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 2 내지 90 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 2 내지 80 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 2 내지 70 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 2 내지 60 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 2 내지 50 mM일 수 있다.In one embodiment of the present invention, the content of the buffer may be 2 to 100 mM. In another embodiment of the present invention, the content of the buffer may be 2 to 90 mM. In another embodiment of the present invention, the content of the buffer may be 2 to 80 mM. In another embodiment of the present invention, the content of the buffer may be 2 to 70 mM. In another embodiment of the present invention, the content of the buffer may be 2 to 60 mM. In another embodiment of the present invention, the content of the buffer may be 2-50 mM.

본 발명의 일 구현예에서, 완충제의 함량은 3 내지 100 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 3 내지 90 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 3 내지 80 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 3 내지 70 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 3 내지 60 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 3 내지 50 mM일 수 있다.In one embodiment of the present invention, the content of the buffer may be 3 to 100 mM. In another embodiment of the present invention, the content of the buffer may be 3 to 90 mM. In another embodiment of the present invention, the content of the buffer may be 3 to 80 mM. In another embodiment of the present invention, the content of the buffer may be 3 to 70 mM. In another embodiment of the present invention, the content of the buffer may be 3 to 60 mM. In another embodiment of the present invention, the content of the buffer may be 3 to 50 mM.

본 발명의 일 구현예에서, 완충제의 함량은 4 내지 100 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 4 내지 90 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 4 내지 80 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 4 내지 70 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 4 내지 60 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 4 내지 50 mM일 수 있다.In one embodiment of the present invention, the content of the buffer may be 4 to 100 mM. In another embodiment of the present invention, the content of the buffer may be 4 to 90 mM. In another embodiment of the present invention, the content of the buffer may be 4 to 80 mM. In another embodiment of the present invention, the content of the buffer may be 4 to 70 mM. In another embodiment of the present invention, the content of the buffer may be 4 to 60 mM. In another embodiment of the present invention, the content of the buffer may be 4-50 mM.

본 발명의 일 구현예에서, 완충제의 함량은 5 내지 100 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 5 내지 90 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 5 내지 80 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 5 내지 70 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 5 내지 60 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 5 내지 50 mM일 수 있다.In one embodiment of the present invention, the content of the buffer may be 5 to 100 mM. In another embodiment of the present invention, the content of the buffer may be 5 to 90 mM. In another embodiment of the present invention, the content of the buffer may be 5 to 80 mM. In another embodiment of the present invention, the content of the buffer may be 5 to 70 mM. In another embodiment of the present invention, the content of the buffer may be 5 to 60 mM. In another embodiment of the present invention, the content of the buffer may be 5 to 50 mM.

본 발명의 일 구현예에서, 완충제의 함량은 1 내지 20 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 5 내지 15 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 7 내지 13 mM일 수 있다. 본 발명의 다른 구현예에서, 완충제의 함량은 10 mM일 수 있다.In one embodiment of the present invention, the content of the buffer may be 1 to 20 mM. In another embodiment of the present invention, the content of the buffer may be 5 to 15 mM. In another embodiment of the present invention, the content of the buffer may be 7 to 13 mM. In another embodiment of the present invention, the content of the buffer may be 10 mM.

(C) 안정화제(C) Stabilizer

본 발명의 일 구현예에서, 본 발명에 따른 안정화제는 i) 금속염, ii) 당 또는 이의 유도체 및 iii) 아미노산(단, 상기 (B) 완충제에 포함되는 아미노산과 상이함) 또는 이의 염으로 구성된 군으로부터 선택되는 어느 하나 이상, 바람직하게는 아미노산일 수 있다. In one embodiment of the present invention, the stabilizer according to the present invention consists of i) a metal salt, ii) a sugar or a derivative thereof, and iii) an amino acid (provided that it is different from the amino acid contained in the (B) buffer) or a salt thereof. It may be any one or more selected from the group, preferably an amino acid.

본 발명의 일 구현예에서, 상기 안정화제는 금속염일 수 있으며, 이의 음이온이 함께 포함될 수 있다. 예를 들어, 상기 금속염은 염화나트륨(NaCl), 염화칼륨(KCl), 염화칼슘(CaCl) 또는 이들 중 2 이상의 혼합물을 포함할 수 있다. In one embodiment of the present invention, the stabilizer may be a metal salt, and an anion thereof may be included together. For example, the metal salt may include sodium chloride (NaCl), potassium chloride (KCl), calcium chloride (CaCl), or a mixture of two or more thereof.

본 발명의 일 구현예에서, 상기 안정화제는 당 또는 당의 유도체일 수 있다. 상기 당은 단당류, 이당류, 올리고당, 다당류 또는 이들 중 2 이상의 혼합물일 수 있다. 단당류의 예로는 글루코스, 프룩토스, 갈락토스 등이 있으나, 이에 제한되지 않는다. 이당류의 예로는 수크로오스, 락토스, 말토스, 트레할로스 등이 있으나, 이에 제한되지 않는다. 올리고당의 예로는 프룩토올리고당, 갈락토올릭고당, 만난올리고당 등이 있으나, 이에 제한되지 않는다. 다당류의 예로는 전분, 글리코겐, 셀룰로스, 키틴, 펙틴 등이 있으나, 이에 제한되지 않는다.In one embodiment of the present invention, the stabilizer may be a sugar or a derivative of sugar. The sugar may be a monosaccharide, a disaccharide, an oligosaccharide, a polysaccharide, or a mixture of two or more thereof. Examples of monosaccharides include, but are not limited to, glucose, fructose, galactose, and the like. Examples of disaccharides include, but are not limited to, sucrose, lactose, maltose, trehalose, and the like. Examples of oligosaccharides include, but are not limited to, fructooligosaccharides, galactooligosaccharides, mannan oligosaccharides, and the like. Examples of polysaccharides include, but are not limited to, starch, glycogen, cellulose, chitin, pectin, and the like.

상기 당의 유도체는 당 알코올, 당 산 또는 이들의 혼합물일 수 있다. 당 알코올의 예로는 글리세롤, 에리스리톨, 트레이톨, 아라비톨, 자이리톨, 리비톨, 만니톨, 소르비톨, 갈락티톨, 푸시톨, 이디톨, 이노시톨, 볼레미톨, 아이소말트, 말티톨, 락티톨, 말토트리이톨, 말토테트라이톨, 폴리글리시톨 등이 있으나, 이에 제한되지 않는다. 당 산의 예로는 알돈산(글리세르산 등), 울로손산(뉴라민산 등), 우론산(글루쿠론산 등), 알다르산(타르타르산 등) 등이 있으나, 이에 제한되지 않는다. 본 발명의 일 구현예에서, 당 또는 이의 유도체는 소르비톨, 만니톨, 트레할로스, 수크로오스 또는 이들 중 2 이상의 혼합물일 수 있고, 바람직하게는 트레할로스일 수 있다. The sugar derivative may be a sugar alcohol, a sugar acid, or a mixture thereof. Examples of sugar alcohols include glycerol, erythritol, threitol, arabitol, xylitol, ribitol, mannitol, sorbitol, galactitol, fusitol, iditol, inositol, bolemitol, isomalt, maltitol, lactitol, maltotriitol , maltotetraitol, polyglycitol, and the like, but is not limited thereto. Examples of sugar acids include, but are not limited to, aldonic acid (such as glyceric acid), ulosonic acid (such as neuramic acid), uronic acid (such as glucuronic acid), and aldaric acid (such as tartaric acid). In one embodiment of the present invention, the sugar or its derivative may be sorbitol, mannitol, trehalose, sucrose, or a mixture of two or more thereof, preferably trehalose.

본 발명의 일 구현예에서, 상기 안정화제는 아미노산 또는 아미노산의 염일 수 있다. 상기 아미노산은 글리신, 아르기닌, 트레오닌, 메티오닌, 또는 이들 중 2 이상의 혼합물일 수 있으나. 이에 한정되는 것은 아니다. 상기 아미노산의 염은 L-아르기닌 모노하이드로클로라이드(monohydrochloride)일 수 있으나, 이에 한정되는 것은 아니다. 본 발명의 일 구현예에 따르면, 상기 안정화제는 바람직하게는 L-아르기닌 모노하이드로클로라이드일 수 있다. In one embodiment of the present invention, the stabilizing agent may be an amino acid or a salt of an amino acid. The amino acid may be glycine, arginine, threonine, methionine, or a mixture of two or more thereof. The present invention is not limited thereto. The salt of the amino acid may be L- arginine monohydrochloride (monohydrochloride), but is not limited thereto. According to one embodiment of the present invention, the stabilizer may be preferably L-arginine monohydrochloride.

본 발명의 일 구현예에서, 상기 안정화제의 함량은 본 발명에 따른 약제학적 제제의 안정성 및 점도에 악영향을 실질적으로 미치지 않는 범위 내에서 자유롭게 조절할 수 있다. 본 발명의 일 구현예에서, 안정화제의 함량은 50 내지 300 mM 또는 1 내지 20%(w/v)일 수 있으나, 이에 한정되지 않는다.In one embodiment of the present invention, the content of the stabilizer can be freely adjusted within a range that does not substantially adversely affect the stability and viscosity of the pharmaceutical formulation according to the present invention. In one embodiment of the present invention, the content of the stabilizer may be 50 to 300 mM or 1 to 20% (w/v), but is not limited thereto.

본 발명의 일 구현예에서, 안정화제로써 아미노산 또는 금속염을 포함하는 경우, 안정화제의 함량은 50 내지 300 mM, 50 내지 290 mM, 50 내지 내지 280 mM, 50 내지 내지 270 mM, 50 내지 내지 260 mM 또는 50 내지 내지 250 mM일 수 있다.In one embodiment of the present invention, when an amino acid or a metal salt is included as a stabilizer, the content of the stabilizer is 50 to 300 mM, 50 to 290 mM, 50 to 280 mM, 50 to 270 mM, 50 to 260 mM or 50 to 250 mM.

본 발명의 다른 구현예에서, 안정화제로써 아미노산 또는 금속염을 포함하는 경우, 안정화제의 함량은 60 내지 300 mM, 60 내지 290 mM, 60 내지 내지 280 mM, 60 내지 내지 270 mM, 60 내지 내지 260 mM 또는 60 내지 내지 250 mM 일 수 있다. In another embodiment of the present invention, when an amino acid or a metal salt is included as a stabilizer, the content of the stabilizer is 60 to 300 mM, 60 to 290 mM, 60 to 280 mM, 60 to 270 mM, 60 to 260 mM or from 60 to 250 mM.

본 발명의 다른 구현예에서, 안정화제로써 아미노산 또는 금속염을 포함하는 경우, 안정화제의 함량은 70 내지 300 mM, 70 내지 290 mM, 70 내지 내지 280 mM, 70 내지 내지 270 mM, 70 내지 내지 260 mM 또는 70 내지 내지 250 mM 일 수 있다.In another embodiment of the present invention, when an amino acid or a metal salt is included as a stabilizer, the content of the stabilizer is 70 to 300 mM, 70 to 290 mM, 70 to 280 mM, 70 to 270 mM, 70 to 260 mM or 70 to 250 mM.

본 발명의 다른 구현예에서, 안정화제로써 아미노산 또는 금속염을 포함하는 경우, 안정화제의 함량은 80 내지 300 mM, 80 내지 290 mM, 80 내지 내지 280 mM, 80 내지 내지 270 mM, 80 내지 내지 260 mM 또는 80 내지 내지 250 mM 일 수 있다.In another embodiment of the present invention, when an amino acid or a metal salt is included as a stabilizer, the content of the stabilizer is 80 to 300 mM, 80 to 290 mM, 80 to 280 mM, 80 to 270 mM, 80 to 260 mM or 80 to 250 mM.

본 발명의 다른 구현예에서, 안정화제로써 아미노산 또는 금속염을 포함하는 경우, 안정화제의 함량은 90 내지 300 mM, 90 내지 290 mM, 90 내지 내지 280 mM, 90 내지 내지 270 mM, 90 내지 내지 260 mM 또는 90 내지 내지 250 mM 일 수 있다.In another embodiment of the present invention, when an amino acid or a metal salt is included as a stabilizer, the content of the stabilizer is 90 to 300 mM, 90 to 290 mM, 90 to 280 mM, 90 to 270 mM, 90 to 260 mM or from 90 to 250 mM.

본 발명의 다른 구현예에서, 안정화제로써 아미노산 또는 금속염을 포함하는 경우, 안정화제의 함량은 100 내지 300 mM, 100 내지 290 mM, 100 내지 내지 280 mM, 100 내지 내지 270 mM, 100 내지 내지 260 mM 또는 100 내지 내지 250 mM 일 수 있다.In another embodiment of the present invention, when an amino acid or a metal salt is included as a stabilizer, the content of the stabilizer is 100 to 300 mM, 100 to 290 mM, 100 to 280 mM, 100 to 270 mM, 100 to 260 mM or from 100 to 250 mM.

본 발명의 일 구현예에서, 안정화제로써 당 또는 당의 유도체를 포함하는 경우, 안정화제의 함량은 본 발명의 안정한 약제학적 제제 총 100 부피 %를 기준으로, 1 내지 20%(w/v), 1 내지 18%(w/v), 1 내지 16%(w/v), 1 내지 14%(w/v), 1 내지 12%(w/v) 또는 1 내지 10%(w/v)일 수 있다.In one embodiment of the present invention, when sugar or a derivative of sugar is included as a stabilizer, the content of the stabilizer is 1 to 20% (w/v), based on 100% by volume of the total stable pharmaceutical formulation of the present invention; 1 to 18% (w/v), 1 to 16% (w/v), 1 to 14% (w/v), 1 to 12% (w/v) or 1 to 10% (w/v) days can

본 발명의 다른 구현예에서, 안정화제로써 당 또는 당의 유도체를 포함하는 경우, 안정화제의 함량은 본 발명의 안정한 약제학적 제제 총 100 부피 %를 기준으로, 2 내지 20%(w/v), 2 내지 18%(w/v), 2 내지 16%(w/v), 2 내지 14%(w/v), 2 내지 12%(w/v) 또는 2 내지 10%(w/v)일 수 있다.In another embodiment of the present invention, when a sugar or a derivative of sugar is included as a stabilizer, the content of the stabilizer is 2 to 20% (w/v), based on 100% by volume of the total stable pharmaceutical formulation of the present invention; 2 to 18% (w/v), 2 to 16% (w/v), 2 to 14% (w/v), 2 to 12% (w/v) or 2 to 10% (w/v) days can

본 발명의 다른 구현예에서, 안정화제로써 당 또는 당의 유도체를 포함하는 경우, 안정화제의 함량은 본 발명의 안정한 약제학적 제제 총 100 부피 %를 기준으로, 3 내지 20%(w/v), 3 내지 18%(w/v), 3 내지 16%(w/v), 3 내지 14%(w/v), 3 내지 12%(w/v) 또는 3 내지 10%(w/v)일 수 있다.In another embodiment of the present invention, when sugar or a derivative of sugar is included as a stabilizer, the content of the stabilizer is 3 to 20% (w/v), based on 100% by volume of the total stable pharmaceutical formulation of the present invention; 3 to 18% (w/v), 3 to 16% (w/v), 3 to 14% (w/v), 3 to 12% (w/v) or 3 to 10% (w/v) days can

본 발명의 다른 구현예에서, 안정화제로써 당 또는 당의 유도체를 포함하는 경우, 안정화제의 함량은 본 발명의 안정한 약제학적 제제 총 100 부피 %를 기준으로, 4 내지 20%(w/v), 4 내지 18%(w/v), 4 내지 16%(w/v), 4 내지 14%(w/v), 4 내지 12%(w/v) 또는 4 내지 10%(w/v)일 수 있다.In another embodiment of the present invention, when sugar or a derivative of sugar is included as a stabilizer, the content of the stabilizer is 4 to 20% (w/v), based on 100% by volume of the total stable pharmaceutical formulation of the present invention; 4 to 18% (w/v), 4 to 16% (w/v), 4 to 14% (w/v), 4 to 12% (w/v) or 4 to 10% (w/v) days can

본 발명의 다른 구현예에서, 안정화제로써 당 또는 당의 유도체를 포함하는 경우, 안정화제의 함량은 본 발명의 안정한 약제학적 제제 총 100 부피 %를 기준으로, 5 내지 20%(w/v), 5 내지 18%(w/v), 5 내지 16%(w/v), 5 내지 14%(w/v), 5 내지 12%(w/v) 또는 5 내지 10%(w/v)일 수 있다.In another embodiment of the present invention, when sugar or a derivative of sugar is included as a stabilizer, the content of the stabilizer is 5 to 20% (w/v), based on 100% by volume of the total stable pharmaceutical formulation of the present invention; 5 to 18% (w/v), 5 to 16% (w/v), 5 to 14% (w/v), 5 to 12% (w/v) or 5 to 10% (w/v) days can

상기 안정화제의 함량 범위 내에서, 장기간동안 고분자량 또는 저분자량 성분은 낮게 유지되고, 온전한 면역글로불린 G성분 또는 온전한 중쇄 및 경쇄의 함량은 높게 유지되며, 장기간 안정성이 우수하며 저점도를 나타낼 수 있다.Within the content range of the stabilizer, the high molecular weight or low molecular weight component is maintained low for a long period of time, the content of the intact immunoglobulin G component or the intact heavy and light chain is maintained high, and it has excellent long-term stability and low viscosity. .

(D) 계면활성제(D) surfactant

본 발명의 일 구현예에서, 본 발명에 따른 계면활성제는 폴리옥시에틸렌소르비탄지방산에스테르 (예를 들면, 폴리소르베이트), 폴리옥시에틸렌알킬에테르 (예를 들면, Brij), 알킬페닐폴리옥시에틸렌에테르 (예를 들면, Triton-X), 폴리옥시에틸렌-폴리옥시프로필렌 코폴리머 (예를 들면, Poloxamer, Pluronic), 나트륨 도데실 설페이트 (SDS), 폴록사머 및 이들의 혼합물 등일 수 있으나, 이에 한정되는 것은 아니다.In one embodiment of the present invention, the surfactant according to the present invention is polyoxyethylene sorbitan fatty acid ester (eg, polysorbate), polyoxyethylene alkyl ether (eg, Brij), alkylphenylpolyoxyethylene ethers (eg Triton-X), polyoxyethylene-polyoxypropylene copolymers (eg Poloxamer, Pluronic), sodium dodecyl sulfate (SDS), poloxamers and mixtures thereof, and the like, but are limited thereto. it is not going to be

본 발명의 일 구현예에서, 상기 계면활성제는 폴리소르베이트, 폴록사머 또는 이들의 혼합물일 수 있으며, 바람직하게는 폴리옥시에틸렌소르비탄지방산에스테르 (폴리소르베이트), 폴록사머 또는 이들의 혼합물일 수 있다. 상기 폴리소르베이트는 폴리소르베이트 20, 폴리소르베이트 40, 폴리소르베이트 60, 폴리소르베이트 80 또는 이들 중 2 이상의 혼합물일 수 있으나, 이에 한정되는 것은 아니다. 상기 폴록사머는 폴록사머 188일 수 있으나, 이에 한정되는 것은 아니다. 본 발명의 다른 구현예에서, 상기 계면활성제는 가장 바람직하게 폴리소르베이트 80일 수 있다.In one embodiment of the present invention, the surfactant may be polysorbate, poloxamer, or a mixture thereof, preferably polyoxyethylene sorbitan fatty acid ester (polysorbate), poloxamer, or a mixture thereof. there is. The polysorbate may be polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 80, or a mixture of two or more thereof, but is not limited thereto. The poloxamer may be poloxamer 188, but is not limited thereto. In another embodiment of the present invention, the surfactant may most preferably be polysorbate 80.

본 발명의 일 구현예에서, 상기 계면활성제의 농도는 본 발명에 따른 안정한 약제학적 제제의 안정성 및 점도에 악영향을 미치지 않는 범위 내에서 자유롭게 조절할 수 있다. 예를 들어, 본 발명에 따른 계면활성제의 농도는 0.01 내지 0.1 %(w/v), 바람직하게는 0.01 내지 0.08%(w/v), 더 바람직하게는 0.01 내지 0.07%(w/v) 일 수 있다. 본 발명에 있어, 상기 계면활성제의 농도는 가장 바람직하게 0.05%(w/v)일 수 있다.In one embodiment of the present invention, the concentration of the surfactant can be freely adjusted within a range that does not adversely affect the stability and viscosity of the stable pharmaceutical formulation according to the present invention. For example, the concentration of the surfactant according to the present invention is 0.01 to 0.1% (w/v), preferably 0.01 to 0.08% (w/v), more preferably 0.01 to 0.07% (w/v) days can In the present invention, the concentration of the surfactant may be most preferably 0.05% (w/v).

(E) pH(E) pH

본 발명의 일 구현예에서, 본 발명에 따른 조성물의 pH는 5.0 내지 7.0일 수 있으며, 5.5 내지 7.0, 5.7 내지 7.0, 6.0 내지 7.0, 6.3 내지 7.0 또는 6.5 내지 7.0일수 있다. In one embodiment of the present invention, the pH of the composition according to the present invention may be 5.0 to 7.0, 5.5 to 7.0, 5.7 to 7.0, 6.0 to 7.0, 6.3 to 7.0 or 6.5 to 7.0.

본 발명의 다른 구현예에서, 본 발명에 따른 조성물의 pH는 5.5 내지 6.5일 수 있으며, 5.7 내지 6.5, 6.0 내지 6.5, 또는 6.3 내지 6.5일수 있다. In another embodiment of the present invention, the pH of the composition according to the present invention may be 5.5 to 6.5, 5.7 to 6.5, 6.0 to 6.5, or 6.3 to 6.5.

본 발명의 다른 구현예에서, 본 발명에 따른 조성물의 pH는 5.5 내지 6.3일 수 있으며, 5.7 내지 6.3, 또는 6.0 내지 6.3일수 있다. In another embodiment of the present invention, the pH of the composition according to the present invention may be 5.5 to 6.3, 5.7 to 6.3, or 6.0 to 6.3.

본 발명의 다른 구현예에서, 본 발명에 따른 조성물의 pH는 5.5 내지 6.0일 수 있으며, 5.7 내지 6.0일수 있다. In another embodiment of the present invention, the pH of the composition according to the present invention may be 5.5 to 6.0, and may be 5.7 to 6.0.

본 발명의 다른 구현예에서, 본 발명에 따른 조성물의 pH는 바람직하게는 6.0일 수 있다. 상기 pH 범위 내에서, 장기간 동안 안정성 및 저점도를 우수하게 나타낼 수 있다. pH는 완충제를 이용하여 조절할 수 있으며, 완충제를 소정의 함량으로 포함하는 경우 별도의 pH 조절제 없이도 상기 범위의 pH를 나타낼 수 있다. In another embodiment of the present invention, the pH of the composition according to the present invention may preferably be 6.0. Within the above pH range, it can exhibit excellent stability and low viscosity for a long period of time. The pH can be adjusted using a buffer, and when the buffer is included in a predetermined amount, the pH of the above range can be exhibited without a separate pH adjusting agent.

(F) "안정한" 약제학적 제제(F) “stable” pharmaceutical formulations

본 명세서에서 용어 "안정한"은 본 발명에 따른 중화 결합 분자가 제조 공정 동안 및/또는 보관/저장 시에 물리적 안정성, 화학적 안정성 및/또는 생물학적 활성을 실질적으로 보유하는 것을 의미한다. 안정성 측정시, 당해 기술분야에서 용이하게 이용할 수 있는, 항체의 안정성을 측정하는 다양한 분석학적 기술을 이용할 수 있다.As used herein, the term “stable” means that the neutralizing binding molecule according to the present invention substantially retains physical stability, chemical stability and/or biological activity during the manufacturing process and/or upon storage/storage. When measuring stability, various analytical techniques for measuring the stability of an antibody that are readily available in the art may be used.

본 발명에 있어, 상기 물리적 안정성은 당해 기술분야에 공지된 방법으로 평가할 수 있으며, 이러한 방법은 광(흡광 또는 광학 밀도)의 샘플 겉보기 감쇠 측정을 포함한다. 이러한 광 감쇠 측정은 제제의 탁도와 관련된다. 또한, 물리적 안정성을 고분자량 성분 함량, 저분자량 성분 함량, 온전한 단백질량, 불용성 이물 입자수 등으로 측정할 수 있다.In the present invention, the physical stability can be evaluated by methods known in the art, which include measuring the sample apparent attenuation of light (absorption or optical density). This light attenuation measurement is related to the turbidity of the formulation. In addition, the physical stability can be measured by high molecular weight component content, low molecular weight component content, intact protein amount, the number of insoluble foreign particles, and the like.

본 발명에 있어, 상기 화학적 안정성은, 예를 들어, 화학적으로 변화된 형태의 중화 결합 분자를 검출하고 정량함으로써 평가할 수 있다. 상기 화학적 안정성은, 예를 들어 이온 교환 크로마토그래피에 의해 평가될 수 있는 하전 변화 (예: 탈아미드화 또는 산화의 결과로서 발생)를 포함한다. 화학적 안정성을 전하 변형체(산성 또는 염기성 피크) 등으로 측정할 수 있다.In the present invention, the chemical stability can be evaluated, for example, by detecting and quantifying a chemically changed form of a neutralizing binding molecule. Such chemical stability includes charge changes (eg, occurring as a result of deamidation or oxidation) that can be assessed, for example, by ion exchange chromatography. Chemical stability can be measured with charge variants (acidic or basic peaks) or the like.

본 발명에 있어, 상기 생물학적 활성은 당해 기술분야에 공지된 방법으로 평가할 수 있으며, 예를 들어 ELISA를 통해 항원 결합 친화도를 측정할 수 있다.In the present invention, the biological activity may be evaluated by a method known in the art, for example, antigen binding affinity may be measured through ELISA.

본 발명의 일 구현예에서, 용어 "안정한 약제학적 제제"는 다음 중 하나 이상을 만족하는 약제학적 제제를 의미한다.In one embodiment of the present invention, the term "stable pharmaceutical preparation" refers to a pharmaceutical preparation satisfying one or more of the following.

(F)-1 탁도 (F)-1 Turbidity

- 온도 5±3℃ 조건에서 4주 동안 보관한 후 분광 광도계로 측정한 흡광도 A600이 0 내지 0.0700 또는 0 내지 0.0400인 약제학적 제제;- A pharmaceutical formulation having an absorbance A600 of 0 to 0.0700 or 0 to 0.0400 measured with a spectrophotometer after storage for 4 weeks at a temperature of 5±3° C.;

- 온도 40±2℃, 상대습도 75±5%, 및 밀폐 조건에서 4주 동안 보관한 후 분광 광도계로 측정한 흡광도 A600이 0 내지 0.0700 또는 0 내지 0.0400인 약제학적 제제;- a pharmaceutical formulation having an absorbance A600 of 0 to 0.0700 or 0 to 0.0400 measured with a spectrophotometer after storage for 4 weeks at a temperature of 40±2° C., a relative humidity of 75±5%, and a closed condition;

(F)-2 주성분 함량(메인 피크)(F)-2 main component content (main peak)

- 온도 5±3℃ 조건에서 4주 동안 보관한 후 SE-HPLC로 측정한 주성분이 98 내지 100%인 약제학적 제제;- A pharmaceutical formulation containing 98 to 100% of the main component as measured by SE-HPLC after storage for 4 weeks at a temperature of 5±3° C.;

- 온도 40±2℃, 상대습도 75±5% 및 밀폐 조건에서 4주 동안 보관한 후 SE-HPLC로 측정한 주성분이 97 내지 100%인 약제학적 제제;- A pharmaceutical formulation containing 97 to 100% of the main component as measured by SE-HPLC after storage for 4 weeks at a temperature of 40±2° C., a relative humidity of 75±5% and a closed condition;

(F)-3 고분자량 성분(메인 피크(온전한 중화 결합 분자)를 기준으로 체류 시간(retention time)이 앞쪽인 피크)(F)-3 high molecular weight component (peak with retention time ahead of the main peak (intact neutralizing binding molecule))

- 온도 5±3℃ 조건에서 4주 동안 보관한 후 SE-HPLC로 측정한 고분자량 성분이 0 내지 1.50%인 약제학적 제제;- A pharmaceutical formulation containing 0 to 1.50% of a high molecular weight component measured by SE-HPLC after storage at a temperature of 5±3° C. for 4 weeks;

- 온도 40±2℃, 상대습도 75±5% 및 밀폐 조건에서 4주 동안 보관한 후 SE-HPLC로 측정한 고분자량 성분이 0 내지 2.0%인 약제학적 제제;- A pharmaceutical formulation containing 0 to 2.0% of high molecular weight components as measured by SE-HPLC after storage for 4 weeks at a temperature of 40±2° C., a relative humidity of 75±5% and a closed condition;

(F)-4 저분자량 성분(메인 피크(온전한 중화 결합 분자)를 기준으로 체류 시간(retention time)이 뒤쪽인 피크)(F)-4 low-molecular-weight component (peak with retention time lag behind the main peak (intact neutralizing binding molecule))

- 온도 5±3℃ 조건에서 4주 동안 보관한 후 SE-HPLC로 측정한 저분자량 성분이 0.0 내지 0.5%인 약제학적 제제;- A pharmaceutical formulation having a low molecular weight component of 0.0 to 0.5% as measured by SE-HPLC after storage at a temperature of 5±3° C. for 4 weeks;

- 온도 40±2℃, 상대습도 75±5% 및 밀폐 조건에서 4주 동안 보관한 후 SE-HPLC로 측정한 저분자량 성분이 0.0 내지 1.5%인 약제학적 제제;- A pharmaceutical formulation containing 0.0 to 1.5% of low molecular weight components measured by SE-HPLC after storage for 4 weeks at a temperature of 40±2° C., a relative humidity of 75±5% and a closed condition;

(F)-5 불용성 이물 입자수(F)-5 Number of insoluble foreign matter particles

- 온도 5±3℃에서 4주 동안 보관 후 HIAC으로 측정한 불용성 이물 입자(10.00㎛≤, <400.00㎛)의 개수는 0 내지 100개인 약제학적 제제;- A pharmaceutical formulation in which the number of insoluble foreign particles (10.00 μm≤, <400.00 μm) measured by HIAC after storage for 4 weeks at a temperature of 5±3° C. is 0 to 100;

- 온도 5±3℃에서 4주 동안 보관 후 HIAC으로 측정한 불용성 이물 입자(25.00㎛≤, <400.00㎛)의 개수는 0 내지 50개인 약제학적 제제;- A pharmaceutical formulation in which the number of insoluble foreign particles (25.00 μm≤, <400.00 μm) measured by HIAC after storage for 4 weeks at a temperature of 5±3° C. is 0 to 50;

- 온도 40±2℃, 상대습도 75±5%, 및 밀폐 조건에서 4주 동안 보관한 후 HIAC으로 측정한 불용성 이물 입자(10.00㎛≤, <400.00㎛)의 개수는 0 내지 200개인 약제학적 제제;- The number of insoluble foreign particles (10.00㎛≤, <400.00㎛) measured by HIAC after storage for 4 weeks at a temperature of 40±2℃, a relative humidity of 75±5%, and a closed condition is 0 to 200 pharmaceutical formulations ;

- 온도 40±2℃, 상대습도 75±5%, 및 밀폐 조건에서 4주 동안 보관한 후 HIAC으로 측정한 불용성 이물 입자(25.00㎛≤, <400.00㎛)의 개수는 0 내지 50개인 약제학적 제제;- The number of insoluble foreign particles (25.00㎛≤, <400.00㎛) measured by HIAC after storage for 4 weeks at a temperature of 40±2℃, a relative humidity of 75±5%, and a closed condition is 0 to 50 pharmaceutical formulations ;

- 온도 5±3℃에서 4주 동안 보관 후 MFI로 측정한 불용성 이물 입자(1.00㎛≤, <400.00㎛)의 개수는 0 내지 5,000개인 약제학적 제제;- A pharmaceutical formulation in which the number of insoluble foreign particles (1.00 μm≤, <400.00 μm) measured by MFI after storage for 4 weeks at a temperature of 5±3° C. is 0 to 5,000;

- 온도 5±3℃에서 4주 동안 보관 후 MFI로 측정한 불용성 이물 입자(10.00㎛≤, <400.00㎛)의 개수는 0 내지 300개인 약제학적 제제;- A pharmaceutical formulation in which the number of insoluble foreign particles (10.00 μm≤, <400.00 μm) measured by MFI after storage for 4 weeks at a temperature of 5±3° C. is 0 to 300;

- 온도 5±3℃에서 4주 동안 보관 후 MFI로 측정한 불용성 이물 입자(25.00㎛≤, <400.00㎛)의 개수는 0 내지 30개인 약제학적 제제;- A pharmaceutical formulation in which the number of insoluble foreign particles (25.00 μm≤, <400.00 μm) measured by MFI after storage for 4 weeks at a temperature of 5±3° C. is 0 to 30;

- 온도 40±2℃, 상대습도 75±5%, 및 밀폐 조건에서 4주 동안 보관한 후 MFI로 측정한 불용성 이물 입자(1.00㎛≤, <400.00㎛)의 개수는 0 내지 20,000개인 약제학적 제제;- The number of insoluble foreign particles (1.00㎛≤, <400.00㎛) measured by MFI after storage for 4 weeks at a temperature of 40±2℃, a relative humidity of 75±5%, and a closed condition is 0 to 20,000 pharmaceutical formulations ;

- 온도 40±2℃, 상대습도 75±5%, 및 밀폐 조건에서 4주 동안 보관한 후 MFI로 측정한 불용성 이물 입자(10.00㎛≤, <400.00㎛)의 개수는 0 내지 300개인 약제학적 제제;- The number of insoluble foreign particles (10.00㎛≤, <400.00㎛) measured by MFI after storage for 4 weeks at a temperature of 40±2℃, a relative humidity of 75±5%, and a closed condition is 0 to 300 pharmaceutical formulations ;

- 온도 40±2℃, 상대습도 75±5%, 및 밀폐 조건에서 4주 동안 보관한 후 MFI로 측정한 불용성 이물 입자(25.00㎛≤, <400.00㎛)의 개수는 0 내지 30개인 약제학적 제제;- The number of insoluble foreign particles (25.00㎛≤, <400.00㎛) measured by MFI after storage for 4 weeks at a temperature of 40±2℃, a relative humidity of 75±5%, and a closed condition is 0 to 30 pharmaceutical formulations ;

(F)-6 산화율(F)-6 oxidation rate

- 온도 5±3℃에서 4주 동안 보관한 후 LC-MS로 측정한 중쇄 Met 263의 산화율이 0% 내지 10%인 약제학적 제제;- a pharmaceutical formulation having an oxidation rate of 0% to 10% of heavy chain Met 263 measured by LC-MS after storage at a temperature of 5±3° C. for 4 weeks;

- 온도 40±2℃, 상대습도 75±5%, 및 밀폐 조건에서 4주 동안 보관한 후 LC-MS로 측정한 중쇄 Met 263의 산화율이 0% 내지 10%인 약제학적 제제;- a pharmaceutical formulation having an oxidation rate of 0% to 10% of heavy chain Met 263 measured by LC-MS after storage for 4 weeks at a temperature of 40±2° C., a relative humidity of 75±5%, and a closed condition;

(F)-7 전하 변형체(F)-7 charge variant

- 온도 5±3℃에서 4주 동안 보관한 후 IEC-HPLC로 측정한 메인 피크 함량이 61% 내지 67%인 약제학적 제제;- a pharmaceutical formulation having a main peak content of 61% to 67% as measured by IEC-HPLC after storage at a temperature of 5±3° C. for 4 weeks;

- 온도 40±2℃, 상대습도 75±5%, 및 밀폐 조건에서 4주 동안 보관한 후 IEC-HPLC로 측정한 메인 피크 함량이 86% 내지 87%인 약제학적 제제.- A pharmaceutical formulation having a main peak content of 86% to 87% as measured by IEC-HPLC after storage for 4 weeks at a temperature of 40±2° C., a relative humidity of 75±5%, and sealed conditions.

[안정한 약제학적 제제의 제조방법][Method for preparing stable pharmaceutical preparations]

본 발명의 안정한 약제학적 제제는 공지된 방법을 이용하여 제조할 수 있으며, 특정 제조 방법으로 제한되지 않는다. 예를 들어, 안정화제 및 계면활성제를 포함하는 용액에 완충제를 첨가하면서 pH를 조절한 후, 이 혼합 용액에 중화 결합 분자를 넣어 약제학적 제제를 제조할 수 있다. 또한, 정제 공정의 최종 단계에서 일부 부형제를 포함하는 용액을 제조한 후 나머지 성분을 첨가하여 약제학적 제제를 제조할 수 있다. The stable pharmaceutical formulation of the present invention can be prepared using a known method, and is not limited to a specific manufacturing method. For example, after adjusting the pH by adding a buffer to a solution containing a stabilizer and a surfactant, a neutralizing binding molecule may be added to the mixed solution to prepare a pharmaceutical formulation. In addition, after preparing a solution containing some excipients in the final step of the purification process, the remaining ingredients may be added to prepare a pharmaceutical formulation.

본 발명의 일 구체예에서, 상기 제제는 제조 시 동결 건조 공정을 포함하지 않을 수 있다. 동결 건조 공정을 포함하지 않은 경우, 예를 들어, 본 발명의 약제학적 제제를 제조하고 멸균 등의 처리 후 바로 1차 포장재인 유리 바이알이나 프리-필드 시린지와 같은 밀폐 용기에 담길 수 있다.In one embodiment of the present invention, the preparation may not include a freeze-drying process during manufacture. If the freeze-drying process is not included, for example, the pharmaceutical formulation of the present invention may be prepared and placed in an airtight container such as a glass vial or pre-filled syringe, which is a primary packaging material, immediately after treatment such as sterilization.

본 발명의 다른 구체예에서, 본 발명의 안정한 약제학적 제제는 (A) 사스-코로나바이러스-2(SARS-CoV-2) 표면의 스파이크 단백질(Spike protein, S protein)에 결합하는 중화 결합 분자 5 내지 240 mg/ml; (B) 완충제 1 내지 50 mM; (C) 안정화제 50 내지 200 mM; 및 (D) 계면활성제 0.01 내지 0.1 %(w/v)를 포함하는 것일 수 있다.In another embodiment of the present invention, the stable pharmaceutical formulation of the present invention is (A) a neutralizing binding molecule 5 that binds to the spike protein (S protein) on the surface of SARS-CoV-2 (SARS-CoV-2) to 240 mg/ml; (B) 1-50 mM buffer; (C) 50-200 mM stabilizer; and (D) 0.01 to 0.1% (w/v) of a surfactant.

본 발명의 다른 구체예에서, 본 발명은 상기 안정한 약제학적 제제; 및 상기 안정한 약제학적 제제를 밀폐된 상태로 수용하는 용기를 포함하는 제품을 제공할 수 있다. In another embodiment of the present invention, the present invention provides the above stable pharmaceutical formulation; And it may provide a product comprising a container for accommodating the stable pharmaceutical formulation in a closed state.

상기 안정한 약제학적 제제는 상술한 바와 같다. The stable pharmaceutical formulation is as described above.

본 발명의 일 구현예에서, 상기 용기는 유리, 폴리머(플라스틱), 금속 등의 물질로부터 형성될 수 있으나, 이에 제한되지 않는다. 본 발명의 일 구현예에서, 상기 용기는 병, 바이알(vial), 카트리지, 주사기(프리-필드 시린지(pre-filled syringe)), 또는 튜브일 수 있으나, 이에 제한되지 않는다. 본 발명의 일 구현예에서, 상기 용기는 유리 또는 폴리머 바이알, 또는 유리 또는 폴리머 프리-필드 시린지일 수 있다. In one embodiment of the present invention, the container may be formed of a material such as glass, polymer (plastic), or metal, but is not limited thereto. In one embodiment of the present invention, the container may be a bottle, a vial, a cartridge, a syringe (pre-filled syringe), or a tube, but is not limited thereto. In one embodiment of the present invention, the container may be a glass or polymer vial, or a glass or polymer pre-filled syringe.

상기 바이알, 카트리지, 프리-필드 시린지 등의 구체적인 제품 형태와 상기 안정한 약제학적 제제를 상기 바이알, 카트리지, 프리-필드 시린지 등에 충진하는 방법은 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자라면 용이하게 입수하거나 실시할 수 있다. 예를 들어, 미국 특허 제4,861,335호, 제6,331,174호 등은 프리-필드 시린지의 구체적인 제품 형태 및 충진 방법을 개시한다. 또한, 상기 바이알, 카트리지, 프리-필드 시린지 등으로서 상용화된 제품을 그대로 이용하거나, 상기 안정한 약제학적 제제의 물성, 투여부위, 투여량 등을 고려하여 별도로 주문 제작한 제품을 이용할 수 있다. The specific product form of the vial, cartridge, pre-filled syringe, etc. and the method of filling the stable pharmaceutical formulation into the vial, cartridge, pre-filled syringe, etc. are easy for those of ordinary skill in the art to which the present invention pertains can be obtained or practiced. For example, US Pat. Nos. 4,861,335, 6,331,174, etc. disclose specific product forms and filling methods of pre-filled syringes. In addition, commercially available products as the vial, cartridge, pre-filled syringe, etc. may be used as it is, or a separately customized product may be used in consideration of the physical properties, administration site, dosage, etc. of the stable pharmaceutical formulation.

본 발명의 일 구현예에서, 상기 제품은 상기 안정한 약제학적 제제의 사용방법, 보관방법 또는 이들 모두를 제공하는 지시사항을 더 포함할 수 있다. In one embodiment of the present invention, the product may further include instructions for providing a method of use, a method of storage, or both of the stable pharmaceutical formulation.

본 발명의 일 구현예에서, 상기 제품은 상업적 및 사용자 관점에서 필요한 기타 도구, 예를 들어 바늘, 주사기 등을 포함할 수 있다.In one embodiment of the present invention, the product may include other tools necessary from a commercial and user point of view, for example, needles, syringes, and the like.

이하 본 발명에서 사용되는 용어를 다음과 같이 정의한다.Hereinafter, terms used in the present invention are defined as follows.

본 발명에서 사용되는 용어 "결합 분자"는 키메라, 인간화 또는 인간 단일클론 항체와 같은 단일클론 항체를 포함하는 온전한(intact) 이뮤노글로불린(immunoglobulin), 또는 항원에 결합하는 이뮤노글로불린인 항원-결합 단편을 포함한다. 예를 들면 SARS-CoV-2의 스파이크 단백질(spike protein)과 결합에 있어서, 온전한(intact) 이뮤노글로불린과 경쟁하는 이뮤노글로불린 단편을 포함하는 가변성 도메인, 효소, 수용체, 단백질을 뜻한다. 구조와는 상관없이 항원-결합 단편은 온전한(intact) 이뮤노글로불린에 의해 인식된 동일한 항원과 결합된다. 상기 항원-결합 단편은 항체의 아미노산 서열의 2개 이상의 연속기, 20개 이상의 연속 아미노산 잔기, 25개 이상의 연속 아미노산 잔기, 30개 이상의 연속 아미노산 잔기, 35개 이상의 연속 아미노산 잔기, 40개 이상의 연속 아미노산 잔기, 50개 이상의 연속 아미노산 잔기, 60개 이상의 연속 아미노산 잔기, 70개 이상의 연속 아미노산 잔기, 80개 이상의 연속 아미노산 잔기, 90개 이상의 연속 아미노산 잔기, 100개 이상의 연속 아미노산 잔기, 125개 이상의 연속 아미노산 잔기, 150개 이상의 연속 아미노산 잔기, 175개 이상 연속 아미노산 잔기, 200개 이상의 연속 아미노산 잔기, 또는 250개 이상의 연속 아미노산 잔기의 아미노산 서열을 포함하는 펩티드 또는 폴리펩티드를 포함할 수 있다. As used herein, the term “binding molecule” refers to an intact immunoglobulin, including monoclonal antibodies, such as chimeric, humanized or human monoclonal antibodies, or antigen-binding, which is an immunoglobulin that binds to an antigen. Includes fragments. For example, in binding to the spike protein of SARS-CoV-2, it refers to a variable domain, enzyme, receptor, or protein comprising an immunoglobulin fragment that competes with an intact immunoglobulin. Regardless of structure, the antigen-binding fragment binds to the same antigen recognized by the intact immunoglobulin. The antigen-binding fragment comprises at least two contiguous groups of the amino acid sequence of the antibody, at least 20 contiguous amino acid residues, at least 25 contiguous amino acid residues, at least 30 contiguous amino acid residues, at least 35 contiguous amino acid residues, at least 40 contiguous amino acid residues , at least 50 contiguous amino acid residues, at least 60 contiguous amino acid residues, at least 70 contiguous amino acid residues, at least 80 contiguous amino acid residues, at least 90 contiguous amino acid residues, at least 100 contiguous amino acid residues, at least 125 contiguous amino acid residues, a peptide or polypeptide comprising an amino acid sequence of at least 150 contiguous amino acid residues, at least 175 contiguous amino acid residues, at least 200 contiguous amino acid residues, or at least 250 contiguous amino acid residues.

본 발명에 있어, 용어 "항원-결합 단편"은 특히 Fab, F(ab'), F(ab')2, Fv, dAb, Fd, 상보성 결정 영역(CDR) 단편, 단일-쇄 항체(scFv), 2가(bivalent) 단일-쇄 항체, 단일-쇄 파지 항체, 디아바디(diabody), 트리아바디, 테트라바디, 폴리펩티드로의 특정 항원에 결합하기에 충분한 이뮤노글로불린의 하나 이상의 단편을 함유하는 폴리펩티드 등을 포함한다. 상기 단편은 합성으로 또는 완전한 이뮤노글로불린의 효소적 또는 화학적 분해에 의해 생성되거나, 재조합 DNA 기술에 의해 유전공학적으로 생성될 수 있다. 생성 방법은 당업계에 잘 알려져 있다.In the context of the present invention, the term "antigen-binding fragment" particularly refers to Fab, F(ab'), F(ab')2, Fv, dAb, Fd, complementarity determining region (CDR) fragments, single-chain antibodies (scFv). , bivalent single-chain antibodies, single-chain phage antibodies, diabodies, triabodies, tetrabodies, polypeptides containing one or more fragments of an immunoglobulin sufficient to bind a particular antigen to the polypeptide. etc. The fragments may be produced synthetically or by enzymatic or chemical degradation of complete immunoglobulins, or may be genetically engineered by recombinant DNA techniques. Methods of production are well known in the art.

본원에 기재된 상기 각 특징들은 조합되어 사용될 수 있으며, 상기 각 특징들이 특허청구범위의 서로 다른 종속항에 기재된다는 사실은 이들이 조합되어 사용될 수 없음을 나타내는 것은 아니다.Each of the features described herein may be used in combination, and the fact that each of the features is recited in different dependent claims of the claims does not indicate that they cannot be used in combination.

본 발명에 따른 안정한 약제학적 제제는 가속 조건 및 가혹 조건과 같은 온도 조건에서 장기간 보관 안정성이 매우 뛰어나며, 빛, 얼림/녹임, 흔들림과 같은 물리적 스트레스 조건에서도 우수한 안정성을 유지할 수 있다.The stable pharmaceutical formulation according to the present invention has excellent long-term storage stability under temperature conditions such as accelerated conditions and severe conditions, and can maintain excellent stability even under physical stress conditions such as light, freezing/thawing, and shaking.

도 1은 실시예 1 내지 3의 주성분 함량의 측정 결과이다.
도 2는 실시예 1 내지 3의 고분자량 성분 함량의 측정 결과이다.
도 3은 실시예 1 내지 3의 저분자량 성분 함량의 측정 결과이다.
도 4는 실시예 1 내지 3의 온전한 면역 글로불린G 함량의 측정 결과이다.
도 5는 실시예 1 내지 3의 항체의 경쇄 및 중쇄 함량의 측정 결과이다.
도 6은 실시예 1 내지 3의 전하 변형체 (메인 피크%) 함량의 측정 결과이다.
도 7은 실시예 1 내지 3의 전하 변형체 (산성 피크%) 함량의 측정 결과이다.
도 8은 실시예 1 내지 3의 전하 변형체 (염기성 피크%) 함량의 측정 결과이다.
도 9는 실시예 1, 4 내지 6의 점도의 측정 결과이다.
도 10은 실시예 1, 7 내지 16의 온도 5±3℃에서 주성분 함량의 측정 결과이다.
도 11은 실시예 1, 7 내지 16의 온도 25±2℃에서 주성분 함량의 측정 결과이다.
도 12는 실시예 1, 7 내지 16의 온도 40±2℃에서 주성분 함량의 측정 결과이다.
도 13은 실시예 1, 7 내지 16의 온전한 면역 글로불린G 함량의 측정 결과이다.
도 14는 실시예 1, 7 내지 16의 항체의 경쇄 및 중쇄 함량의 측정 결과이다.
도 15은 실시예 1, 7 내지 16의 전하 변형체 (메인 피크%) 함량의 측정 결과이다.
도 16은 실시예 1, 7 내지 16의 전하 변형체 (산성 피크%) 함량의 측정 결과이다.
도 17은 실시예 1, 7 내지 16의 전하 변형체 (염기성 피크%) 함량의 측정 결과이다.
도 18은 실시예 17 내지 19의 항체의 경쇄 및 중쇄 함량의 측정 결과이다.
도 19는 실시예 17 내지 19의 온전한 면역 글로불린G 함량의 측정 결과이다.
도 20은 실시예 17 내지 19의 주성분 함량의 측정 결과이다.
도 21은 실시예 17 내지 19의 고분자량 성분 함량의 측정 결과이다.
도 22는 실시예 17 내지 19의 저분자량 성분 함량의 측정 결과이다.
도 23은 실시예 1, 20 내지 31 및 비교예 1의 온전한 면역 글로불린G 함량의 측정 결과이다.
도 24는 실시예 1, 20 내지 31 및 비교예 1의 항체의 경쇄 및 중쇄 함량의 측정 결과이다.
도 25는 실시예 1, 20 내지 31 및 비교예 1의 주성분 함량의 측정 결과이다.1 is a measurement result of the main component content of Examples 1 to 3.
2 is a measurement result of the high molecular weight component content of Examples 1 to 3.
3 is a measurement result of the content of low molecular weight components of Examples 1 to 3.
4 is a measurement result of the intact immunoglobulin G content of Examples 1 to 3.
5 is a measurement result of the light chain and heavy chain content of the antibodies of Examples 1 to 3.
6 is a measurement result of the charge variant (main peak %) content of Examples 1 to 3;
7 is a measurement result of the charge variant (acid peak %) content of Examples 1 to 3;
8 is a measurement result of the charge variant (basic peak %) content of Examples 1 to 3;
9 is a measurement result of the viscosity of Examples 1, 4 to 6;
10 is a measurement result of the content of the main component at a temperature of 5±3° C. in Examples 1 and 7 to 16. FIG.
11 is a measurement result of the content of the main component at a temperature of 25±2° C. in Examples 1 and 7 to 16. FIG.
12 is a measurement result of the content of the main component at a temperature of 40±2° C. in Examples 1 and 7 to 16. FIG.
13 is a measurement result of intact immunoglobulin G content of Examples 1 and 7 to 16.
14 is a measurement result of the light chain and heavy chain content of the antibodies of Examples 1 and 7 to 16.
15 is a measurement result of the content of charge variants (main peak %) of Examples 1 and 7 to 16;
16 is a measurement result of the content of charge variants (acid peak %) of Examples 1 and 7 to 16;
17 is a measurement result of the content of charge variants (basic peak %) of Examples 1 and 7 to 16;
18 is a measurement result of the light chain and heavy chain content of the antibodies of Examples 17 to 19.
19 is a measurement result of the intact immunoglobulin G content of Examples 17 to 19.
20 is a measurement result of the main component content of Examples 17 to 19.
21 is a measurement result of the high molecular weight component content of Examples 17 to 19.
22 is a measurement result of the content of low molecular weight components of Examples 17 to 19.
23 is a measurement result of intact immunoglobulin G content of Examples 1, 20 to 31, and Comparative Example 1. FIG.
24 is a measurement result of the light chain and heavy chain content of the antibodies of Examples 1, 20 to 31 and Comparative Example 1.
25 is a measurement result of the main component content of Examples 1, 20 to 31, and Comparative Example 1.

이하 본 발명을 실시예를 통해 상세히 설명한다. 하기 실시예들은 본 발명의 내용을 예시하는 것일 뿐 발명의 범위가 실시예에 의해 한정되지 않는다. 본 발명에서 인용된 문헌은 본 발명의 명세서에 참조로서 통합된다.Hereinafter, the present invention will be described in detail through examples. The following examples are merely illustrative of the content of the present invention, and the scope of the present invention is not limited by the examples. The documents cited herein are incorporated herein by reference.

아래 실험예에서 사용된 중화 결합 분자와 관련하여, 안정화제를 첨가한 완충액을 최적의 완충 능력을 보이는 pH에 맞게 제조한 뒤, 해당 용액에 SARS-CoV-2 중화 결합 분자를 첨가하고, 계면활성제를 목표 농도에 도달하도록 첨가하여 해당 제형 성분을 제조하였다.With respect to the neutralizing binding molecules used in the experimental examples below, a buffer solution containing a stabilizer was prepared at a pH that showed the optimal buffering ability, and then SARS-CoV-2 neutralizing binding molecules were added to the solution, and a surfactant was added. was added to reach the target concentration to prepare the corresponding formulation component.

또한, 아래 실험예에서 사용된 약제학적 제제의 물리적 안정성, 화학적 안정성 및 생물학적 활성의 측정방법으로서 다음과 같은 방법을 사용하였다.In addition, the following method was used as a method for measuring the physical stability, chemical stability and biological activity of the pharmaceutical formulation used in the experimental examples below.

- 탁도(Turbidity)- Turbidity

UV-Vis 분광 광도계를 이용하여 600 nm에서의 흡광도를 측정하였다.The absorbance at 600 nm was measured using a UV-Vis spectrophotometer.

- 주성분 함량- Main ingredient content

크기 배제 고성능 액체 크로마토그래피(Size Exclusion HPLC)를 이용하여 주성분 함량(main peak; %)을 측정하였다.The main component content (%) was measured using size exclusion high performance liquid chromatography (Size Exclusion HPLC).

- 고분자량 성분 함량- High molecular weight component content

크기 배제 고성능 액체 크로마토그래피(Size Exclusion HPLC)를 이용하여 고분자량 성분의 함량(pre-peak; %)을 측정하였다.The content (pre-peak; %) of the high molecular weight component was measured using size exclusion high performance liquid chromatography (Size Exclusion HPLC).

- 저분자량 성분 함량- Low molecular weight ingredient content

크기 배제 고성능 액체 크로마토그래피(Size Exclusion HPLC)를 이용하여 저분자량 성분의 함량(post-peak; %)을 측정하였다.The content (post-peak; %) of low molecular weight components was measured using size exclusion high performance liquid chromatography (Size Exclusion HPLC).

- 온전한 면역 글로불린 G의 함량- Content of intact immunoglobulin G

비환원 Chip-based CE-SDS 분석 장비인 Labchip GXII를 이용하여 온전한 면역글로불린 G의 함량을 측정하였다.The content of intact immunoglobulin G was measured using Labchip GXII, a non-reducing chip-based CE-SDS analysis equipment.

- 항체 경쇄와 중쇄의 함량- Content of antibody light and heavy chains

환원 Chip-based CE-SDS 분석 장비인 Labchip GXII를 이용하여 항체의 경쇄와 중쇄의 함량을 측정하였다.The contents of light and heavy chains of the antibody were measured using Labchip GXII, a reduced chip-based CE-SDS analysis equipment.

- 불용성 이물 입자(Sub-visible particles)의 수- Number of insoluble foreign particles (Sub-visible particles)

마이크로 플로우 이미징 (Micro Flow Imaging; MFI) 및 광 차폐형 미립자 계수기 (모델명: HIAC 9703)를 이용하여 불용성 이물 입자의 수를 측정하였다.The number of insoluble foreign particles was measured using Micro Flow Imaging (MFI) and a light-shielding particle counter (model name: HIAC 9703).

- 산화율(Oxidation)- Oxidation

질량분석을 통한 액체 크로마토그래피(LC-MS)로 펩티드 매핑(Peptide mapping)을 통해 중쇄 Met 263의 산화율(%)을 측정하였다.The oxidation rate (%) of heavy chain Met 263 was measured through peptide mapping by liquid chromatography (LC-MS) through mass spectrometry.

- 전하 변형체 - charge variant

이온 교환 크로마토그래피 (Ion exchange chromatography)로 산성 및 염기성 피크(%)를 측정하였다.Acidic and basic peaks (%) were measured by ion exchange chromatography.

- SARS-CoV-2 RBD 결합 친화도- SARS-CoV-2 RBD binding affinity

효소결합면역흡착 분석법(Enzyme-Linked ImmunoSorbent Assay; ELISA)으로 SARS-CoV-2 RBD 결합 친화도(%)를 측정하였다.SARS-CoV-2 RBD binding affinity (%) was measured by Enzyme-Linked ImmunoSorbent Assay (ELISA).

실험예 1: L-아르기닌-HCl/소르비톨/트레할로스 안정화제의 비교Experimental Example 1: Comparison of L-arginine-HCl/sorbitol/trehalose stabilizer

실험예 1에서 사용된 약제학적 제제와 관련하여, 각 완충액을 각 pH에 맞게 제조한 뒤 아르기닌 모노하이드로클로라이드, 소르비톨 및 트레할로스를 첨가하고, 이에 항체를 첨가하고, 계면활성제를 첨가하여 표 5의 시료들을 제조하였다. 실시예 1 내지 3에 따라 제조된 약제학적 제제를 5±3℃ 온도와 50±2℃ 온도에서 보관하였고, 5±3℃ 온도에서 5일 후의 안정성 그리고 50±2℃ 온도에서 3일 후 및 5일 후의 안정성을 측정하였다. 물리적 스트레스를 위해 -40℃에서 얼림과 녹임 5회를 반복하였다. 실험의 결과는 표 6 내지 18 및 도 1 내지 8에 나타내었다.With respect to the pharmaceutical formulation used in Experimental Example 1, each buffer was prepared to suit each pH, and arginine monohydrochloride, sorbitol and trehalose were added thereto, an antibody was added thereto, and a surfactant was added to the sample of Table 5 were manufactured. The pharmaceutical formulations prepared according to Examples 1 to 3 were stored at a temperature of 5±3° C. and a temperature of 50±2° C., and the stability after 5 days at a temperature of 5±3° C. and after 3 days at a temperature of 50±2° C. and 5 Stability after one day was measured. For physical stress, freezing and thawing at -40°C were repeated 5 times. The results of the experiment are shown in Tables 6 to 18 and FIGS. 1 to 8 .

본 실험예 1에서 사용된 항체는 상기 표 1 내지 표 2에 기재된 No. 139번 결합 분자이다.The antibody used in Experimental Example 1 was No. 1 described in Tables 1 to 2 above. 139 is the binding molecule.

실험 결과, 하기 성분으로 제조된 제형은 가속 조건 및 가혹 조건과 같은 온도 조건에서 안정성이 매우 뛰어나며, 얼림/녹임과 같은 물리적 스트레스 조건에서도 우수한 안정성을 유지함을 확인하였다. 실험한 안정화제 중 L-아르기닌 모노하이드로클로라이드를 포함한 제형에서 주성분 함량 및 온전한 면역글로불린 G의 함량이 소르비톨 및 트레할로스를 포함하는 제형보다 높은 온도 조건에서 더 안정함을 알 수 있었다.As a result of the experiment, it was confirmed that the formulation prepared with the following ingredients had excellent stability under temperature conditions such as accelerated conditions and severe conditions, and maintained excellent stability even under physical stress conditions such as freezing/thawing. Among the tested stabilizers, it was found that the main component content and the intact immunoglobulin G content in the formulation containing L-arginine monohydrochloride were more stable under high temperature conditions than the formulation containing sorbitol and trehalose.

구분division 완충제buffer pHpH 안정화제stabilizer 계면활성제Surfactants 단백질(항체) 농도Protein (antibody) concentration 실시예 1Example 1 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌 모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 2Example 2 히스티딘 10 mMhistidine 10 mM 6.06.0 소르비톨 5% (w/v)Sorbitol 5% (w/v) 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 3Example 3 히스티딘 10 mMhistidine 10 mM 6.06.0 트레할로스 10% (w/v)Trehalose 10% (w/v) 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL

하기 표 6에서 탁도 측정 결과를 나타내었다.The turbidity measurement results are shown in Table 6 below.

구분division 5±3℃5±3℃
0일 후 (T=0)After 0 days (T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 얼림/녹임 스트레스Freeze/Thaw Stress 실시예 1Example 1 0.03700.0370 0.00550.0055 0.00960.0096 0.01080.0108 0.00680.0068 실시예 2Example 2 0.01210.0121 0.01620.0162 0.01570.0157 0.04120.0412 0.00700.0070 실시예 3Example 3 0.00820.0082 0.00370.0037 0.00900.0090 0.00590.0059 0.00590.0059

표 6을 보면 5±3℃, 50±2℃ 그리고 얼림/녹임 스트레스 조건에서 실시예 1의 탁도가 0.0400 이하였다. 실시예 2의 경우 50±2℃ 조건에서 실시예 1의 탁도 보다 높았다. Referring to Table 6, the turbidity of Example 1 was 0.0400 or less under conditions of 5±3° C., 50±2° C. and freeze/thaw stress. In the case of Example 2, the turbidity of Example 1 was higher than that of 50±2° C. conditions.

하기 표 7에서 크기배제 크로마토그래피 주성분 함량 (Main peak %) 측정 결과를 나타내었다.Table 7 below shows the measurement results of the main component content (Main peak %) by size exclusion chromatography.

구분division 5±3℃5±3℃
0일 후 (T=0)After 0 days (T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 얼림/녹임 스트레스Freeze/Thaw Stress 실시예 1Example 1 99.8299.82 99.8299.82 99.6299.62 99.4599.45 99.8699.86 실시예 2Example 2 99.7499.74 99.7899.78 99.5399.53 99.3399.33 99.8899.88 실시예 3Example 3 99.7699.76 99.7899.78 99.3699.36 99.2999.29 99.8799.87

표 7을 보면 5±3℃및 50±2℃ 조건에서 실시예 1이 가장 높은 주성분 함량을 포함하였다. 실시예1 내지 3의 주성분 함량은 50±2℃ 조건에서 5일 후 98.0% 이상으로 안정함을 알 수 있었다. 얼림/녹임 스트레스에 의한 주성분 함량은 실시예 1 내지 3가 유사하며, 98.0% 이상으로 안정함을 알 수 있었다 (도 1).Referring to Table 7, Example 1 contained the highest content of main components under the conditions of 5±3°C and 50±2°C. It can be seen that the main component content of Examples 1 to 3 is stable to 98.0% or more after 5 days at 50±2° C. condition. The content of the main component due to freezing/thawing stress was similar to Examples 1 to 3, and it was found that it was stable at 98.0% or more ( FIG. 1 ).

하기 표 8에서 크기배제 크로마토그래피 고분자량 성분 함량 (pre-peak %) 측정 결과를 나타내었다.Table 8 below shows the measurement results of the high molecular weight component content (pre-peak %) by size exclusion chromatography.

구분division 5±3℃5±3℃
0일 후 (T=0)After 0 days (T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 얼림/녹임 스트레스Freeze/Thaw Stress 실시예 1Example 1 0.140.14 0.140.14 0.200.20 0.240.24 0.090.09 실시예 2Example 2 0.230.23 0.170.17 0.310.31 0.400.40 0.080.08 실시예 3Example 3 0.200.20 0.170.17 0.480.48 0.410.41 0.100.10

표 8을 보면 실시예 1의 5일 후 5±3℃ 및 3일 및 5일 후 50±2℃ 조건이 가장 낮은 고분자량 성분 함량을 나타내었다. 실시예 1 내지 3의 고분자량 성분 함량은 50±2℃ 조건에서 5일 후 1.00% 이하로 안정함을 알 수 있었다. 얼림/녹임 스트레스에 의한 고분자량 함량은 실시예 1 내지 3가 유사하며, 1.00% 이하로 안정함을 알 수 있었다 (도 2).Referring to Table 8, the conditions of 5±3° C. after 5 days and 50±2° C. after 3 days and 5 days of Example 1 showed the lowest content of high molecular weight components. It was found that the content of the high molecular weight component of Examples 1 to 3 was stable to 1.00% or less after 5 days at 50±2°C. The high molecular weight content due to freezing/thawing stress was similar to Examples 1 to 3, and it was found that it was stable at 1.00% or less ( FIG. 2 ).

하기 표 9에서 크기배제 크로마토그래피 저분자량 성분 함량 (post-peak %) 측정 결과를 나타내었다.Table 9 below shows the measurement results of the low molecular weight component content (post-peak %) by size exclusion chromatography.

구분division 5±3℃5±3℃
0일 후 (T=0)After 0 days (T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 얼림/녹임 스트레스Freeze/Thaw Stress 실시예 1Example 1 0.040.04 0.040.04 0.180.18 0.310.31 0.050.05 실시예 2Example 2 0.040.04 0.040.04 0.160.16 0.270.27 0.040.04 실시예 3Example 3 0.040.04 0.050.05 0.160.16 0.300.30 0.030.03

표 9를 보면 모든 조건에서 실시예 1 내지 3의 저분자량 함량이 0.5% 이하임을 확인하였다 (도 3).Referring to Table 9, it was confirmed that the low molecular weight content of Examples 1 to 3 was 0.5% or less under all conditions (FIG. 3).

하기 표 10에서 온전한 면역 글로불린G의 함량 (비환원 chip-based CE-SDS) 측정 결과를 나타내었다.Table 10 below shows the measurement results of intact immunoglobulin G content (non-reducing chip-based CE-SDS).

구분division 5±3℃5±3℃
0일후0 days later
(T=0)(T=0) 5±3℃5±3℃
5일후5 days later 50±2℃50±2℃
3일후3 days later 50±2℃50±2℃
5일후5 days later 얼림/녹임 스트레스Freeze/Thaw Stress 실시예1Example 1 94.9394.93 94.9594.95 95.1195.11 95.0895.08 94.9194.91 실시예2Example 2 95.0695.06 95.195.1 94.794.7 94.394.3 95.1495.14 실시예3Example 3 95.2395.23 95.1895.18 94.7394.73 94.5494.54 94.9694.96

(단위: %)(unit: %)

표 10을 보면 실시예 1의 5일 후 5±3℃ 및 3일 및 5일 후 50±2℃ 조건에서 가장 높은 온전한 면역 글로불린G의 함량을 나타내었다. 실시예 1 내지 3의 온전한 면역 글로불린G의 함량은 50±2℃ 조건에서 5일 후 90.0% 이상으로 안정함을 알 수 있었다. 얼림/녹임 스트레스에 의한 고분자량 함량은 실시예 1 내지 3이 유사하며, 90.0% 이상으로 안정함을 알 수 있었다 (도 4).Referring to Table 10, the highest intact immunoglobulin G content was shown in Example 1 at 5±3° C. after 5 days and at 50±2° C. after 3 and 5 days. It was found that the content of intact immunoglobulin G of Examples 1 to 3 was stable to 90.0% or more after 5 days at 50±2°C. The high molecular weight content due to freezing/thawing stress was similar to Examples 1 to 3, and it was found that it was stable at 90.0% or more (FIG. 4).

하기 표 11에서 항체 경쇄와 중쇄의 함량 (환원 chip-based CE-SDS) 측정 결과를 나타내었다.Table 11 below shows the measurement results of the antibody light chain and heavy chain content (reduced chip-based CE-SDS).

　구분division 5±3℃5±3℃
0일후0 days later
(T=0)(T=0) 5±3℃5±3℃
5일후5 days later 50±2℃50±2℃
3일후3 days later 50±2℃50±2℃
5일후5 days later 얼림/녹임 스트레스Freeze/Thaw Stress 실시예1Example 1 99.899.8 99.8199.81 99.7399.73 99.6799.67 99.899.8 실시예2Example 2 99.8199.81 99.7999.79 99.7299.72 99.6299.62 99.7999.79 실시예3Example 3 99.7999.79 99.7899.78 99.7299.72 99.6499.64 99.7899.78

(단위: %)(unit: %)

표 11을 통해 모든 조건에서 실시예 1 내지 3의 항체 경쇄와 중쇄 함량이 98.0 % 이상임을 확인하였다 (도 5).From Table 11, it was confirmed that the antibody light chain and heavy chain contents of Examples 1 to 3 were 98.0% or more under all conditions (FIG. 5).

하기 표 12에서 전하 변형체 (메인 피크 %) 측정 결과를 나타내었다.Table 12 below shows the measurement results of the charge variant (main peak %).

　구분division 5±3℃5±3℃
0일후0 days later
(T=0)(T=0) 5±3℃5±3℃
5일후5 days later 50±2℃50±2℃
3일후3 days later 50±2℃50±2℃
5일후5 days later 얼림/녹임 스트레스Freeze/Thaw Stress 실시예1Example 1 6565 65.4865.48 64.6764.67 63.3563.35 65.5665.56 실시예2Example 2 65.1265.12 65.3965.39 64.2164.21 62.6762.67 65.3965.39 실시예3Example 3 65.1465.14 64.9264.92 64.0364.03 62.9262.92 65.2565.25

표 12를 통해 모든 조건에서 실시예 1 내지 3의 전하 변형체 (메인 피크 %) 함량이 유사한 수준임을 확인하였다 (도 6).Through Table 12, it was confirmed that the contents of the charge variants (main peak %) of Examples 1 to 3 were at a similar level under all conditions ( FIG. 6 ).

하기 표 13에서 전하 변형체 (산성 피크 %) 측정 결과를 나타내었다.Table 13 below shows the measurement results of the charge variant (acid peak %).

　구분division 5±3℃5±3℃
0일후0 days later
(T=0)(T=0) 5±3℃5±3℃
5일후5 days later 50±2℃50±2℃
3일후3 days later 50±2℃50±2℃
5일후5 days later 얼림/녹임 스트레스Freeze/Thaw Stress 실시예1Example 1 7.667.66 7.567.56 10.6610.66 14.8314.83 7.227.22 실시예2Example 2 7.657.65 7.797.79 11.4611.46 15.9815.98 7.557.55 실시예3Example 3 7.717.71 7.847.84 11.6411.64 15.8415.84 7.517.51

표 13을 통해 모든 조건에서 실시예 1 내지 3의 전하 변형체 (산성 피크 %) 함량이 유사한 수준임 확인하였다 (도 7).Through Table 13, it was confirmed that the contents of the charge variants (acid peak %) of Examples 1 to 3 were at a similar level under all conditions ( FIG. 7 ).

하기 표 14에서 전하 변형체 (염기성 피크 %) 측정 결과를 나타내었다.Table 14 below shows the measurement results of charge variants (basic peak %).

　구분division 5±3℃5±3℃
0일후0 days later
(T=0)(T=0) 5±3℃5±3℃
5일후5 days later 50±2℃50±2℃
3일후3 days later 50±2℃50±2℃
5일후5 days later 얼림/녹임 스트레스Freeze/Thaw Stress 실시예1Example 1 27.3327.33 26.9726.97 24.6724.67 21.8121.81 27.2327.23 실시예2Example 2 27.2227.22 26.8326.83 24.3324.33 21.3421.34 27.0727.07 실시예3Example 3 27.1427.14 27.2527.25 24.3424.34 21.2321.23 27.2427.24

표 14를 통해 모든 조건에서 실시예 1 내지 3의 전하 변형체 (염기성 피크 %) 함량이 유사한 수준임을 확인하였다(도 8).Through Table 14, it was confirmed that the contents of the charge variants (basic peak %) of Examples 1 to 3 were at a similar level under all conditions ( FIG. 8 ).

하기 표 15에서 MFI 로 측정한 불용성 이물 입자의 수(10.00㎛≤, <100.00㎛) 측정 결과를 나타내었다.Table 15 below shows the measurement results of the number of insoluble foreign particles (10.00 μm≤, <100.00 μm) measured by MFI.

　구분division 5±3℃5±3℃
0일후0 days later
(T=0)(T=0) 5±3℃5±3℃
5일후5 days later 50±2℃50±2℃
3일후3 days later 50±2℃50±2℃
5일후5 days later 얼림/녹임 스트레스Freeze/Thaw Stress 실시예1Example 1 33 2626 1111 22 33 실시예2Example 2 55 1010 55 1010 22 실시예3Example 3 33 22 1010 22 1818

표 15를 보면 실시예 1 내지 3의 불용성 이물 입자의 수가 모든 조건에서 6000개 이하로 안정함을 알 수 있었다. Looking at Table 15, it can be seen that the number of insoluble foreign particles of Examples 1 to 3 is stable to 6000 or less under all conditions.

하기 표 16에서 MFI 로 측정한 불용성 이물 입자의 수(25.00㎛≤, <100.00㎛) 측정 결과를 나타내었다.Table 16 below shows the measurement results of the number of insoluble foreign particles (25.00 μm≤, <100.00 μm) measured by MFI.

　구분division 5±3℃5±3℃
0일후0 days later
(T=0)(T=0) 5±3℃5±3℃
5일후5 days later 50±2℃50±2℃
3일후3 days later 50±2℃50±2℃
5일후5 days later 얼림/녹임 스트레스Freeze/Thaw Stress 실시예1Example 1 00 00 33 00 22 실시예2Example 2 22 22 33 22 00 실시예3Example 3 00 00 00 00 00

표 16을 보면 실시예 1 내지 3의 불용성 이물 입자의 수가 모든 조건에서 600개 이하로 안정함을 알 수 있었다.Looking at Table 16, it can be seen that the number of insoluble foreign particles of Examples 1 to 3 is stable at 600 or less under all conditions.

하기 표 17에서 HIAC으로 측정한 불용성 이물 입자의 수(10.00≤(um)) 측정 결과를 나타내었다.Table 17 below shows the measurement results of the number of insoluble foreign particles (10.00≤(um)) measured by HIAC.

　구분division 5±3℃5±3℃
0일후0 days later
(T=0)(T=0) 5±3℃5±3℃
5일후5 days later 50±2℃50±2℃
3일후3 days later 50±2℃50±2℃
5일후5 days later 얼림/녹임 스트레스Freeze/Thaw Stress 실시예1Example 1 22 00 00 22 00 실시예2Example 2 77 00 33 00 00 실시예3Example 3 00 00 00 33 00

표 17을 보면 실시예 1 내지 3의 불용성 이물 입자의 수가 모든 조건에서 10개 이하로 안정함을 알 수 있다. Referring to Table 17, it can be seen that the number of insoluble foreign particles of Examples 1 to 3 is stable to 10 or less under all conditions.

하기 표 18에서 HIAC으로 측정한 불용성 이물 입자의 수(25.00≤(um)) 측정 결과를 나타내었다.In Table 18, the number of insoluble foreign particles (25.00≤(um)) measured by HIAC is shown.

　구분division 5±3℃5±3℃
0일후0 days later
(T=0)(T=0) 5±3℃5±3℃
5일후5 days later 50±2℃50±2℃
3일후3 days later 50±2℃50±2℃
5일후5 days later 얼림/녹임 스트레스Freeze/Thaw Stress 실시예1Example 1 22 00 00 00 00 실시예2Example 2 00 00 00 00 00 실시예3Example 3 00 00 00 22 00

표 18을 보면 실시예 1 내지 3의 불용성 이물 입자의 수가 모든 조건에서 5개 이하로 안정함을 알 수 있었다.Referring to Table 18, it was found that the number of insoluble foreign particles of Examples 1 to 3 was stable to 5 or less under all conditions.

실험예 2: 고농도 항체 단백질 제제의 비교Experimental Example 2: Comparison of high-concentration antibody protein preparations

실험예 2에서 사용된 약제학적 제제와 관련하여, 각 완충액을 각 pH에 맞게 제조한 뒤 아르기닌 모노하이드로클로라이드를 첨가하고, 이에 항체를 첨가 후 농축하였다. 그 후 계면활성제를 첨가하여 표 19의 시료들을 제조하였다. 실시예 4 내지 6은 셀트리온 연구소에서 농축한 항체를 첨가했으며 실시예 1은 실험예 1에 따라 최종적으로 선정된 제제이다. 제조된 약제학적 제제를 5±3℃ 온도와 40±2℃ 온도 및 75±5% 상대 습도에서 보관하였고, 5±3℃ 온도에서 2주 및 4주 후의 안정성 그리고 40±2℃ 온도 및 75±5% 상대 습도에서 2주 후 및 4주 후의 안정성을 측정하였다. 물리적 스트레스를 위해 상온 조건에서 3000 rpm으로 4시간의 흔들림 스트레스를 주었으며 결과는 표 20 내지 27 및 도 9에 나타내었다. With respect to the pharmaceutical formulation used in Experimental Example 2, each buffer was prepared to suit each pH, arginine monohydrochloride was added thereto, and the antibody was added thereto and then concentrated. Then, a surfactant was added to prepare the samples in Table 19. Examples 4 to 6 added the antibody concentrated in Celltrion Research Institute, and Example 1 is a formulation finally selected according to Experimental Example 1. The prepared pharmaceutical formulation was stored at 5±3°C temperature, 40±2°C temperature and 75±5% relative humidity, and stability after 2 and 4 weeks at 5±3°C temperature and 40±2°C temperature and 75± Stability after 2 weeks and 4 weeks at 5% relative humidity was measured. For physical stress, shaking stress was applied at 3000 rpm at room temperature for 4 hours, and the results are shown in Tables 20 to 27 and FIG. 9 .

본 실험예 2에 사용된 항체는 상기 표 1 내지 표 2에 기재된 No. 139번 결합 분자이다.Antibodies used in Experimental Example 2 were No. 1 described in Tables 1 to 2 above. 139 is the binding molecule.

구분division 완충제buffer pHpH 안정화제stabilizer 계면활성제Surfactants 단백질(항체) 농도Protein (antibody) concentration 실시예 4Example 4 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌
모노하이드로클로라이드
150 mML-Arginine
monohydrochloride
150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 100
mg/mL100
mg/mL 실시예 5Example 5 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌모노하이드로클로라이드
150 mML-Arginine Monohydrochloride
150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 150
mg/mL150
mg/mL 실시예 6Example 6 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌모노하이드로클로라이드
150 mML-Arginine Monohydrochloride
150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 200
mg/mL200
mg/mL 실시예 1Example 1 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌모노하이드로클로라이드
150 mML-Arginine Monohydrochloride
150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL

하기 표 20에서 점도 (단위: cP) 측정 결과를 나타내었다.The viscosity (unit: cP) measurement results are shown in Table 20 below.

　구분division 5±3℃
0일 후
(T=0)5±3℃
after 0 days
(T=0) 5±3℃
2주후5±3℃
After two weeks 40±2℃
2주후40±2℃
After two weeks 5±3℃
4주후5±3℃
4 weeks later 40±2℃
4주후40±2℃
4 weeks later 흔들림 스트레스shake stress 실시예 4Example 4 2.62.6 2.62.6 2.62.6 2.62.6 2.62.6 2.62.6 실시예 5Example 5 6.06.0 6.06.0 6.06.0 5.85.8 5.95.9 6.06.0 실시예 6Example 6 13.813.8 12.912.9 12.912.9 12.912.9 13.013.0 12.112.1 실시예 1Example 1 1.71.7 1.71.7 1.61.6 1.71.7 1.71.7 1.71.7

표 20에서 실시예 1 및 4 내지 6의 점도는 모든 실험 조건에서 변화하지 않았으며 피하주사가 가능한 15.0 cP 이하였다 (도 9).In Table 20, the viscosity of Examples 1 and 4 to 6 did not change in all experimental conditions and was 15.0 cP or less for subcutaneous injection (FIG. 9).

하기 표 21에서 SARS-CoV-2 RBD 결합 친화도 (ELISA) 측정 결과를 나타내었다.Table 21 below shows the measurement results of SARS-CoV-2 RBD binding affinity (ELISA).

　구분division 5±3℃
0일 후
(T=0)5±3℃
after 0 days
(T=0) 5±3℃
2주후5±3℃
After two weeks 40±2℃
2주후40±2℃
After two weeks 5±3℃
4주후5±3℃
4 weeks later 40±2℃
4주후40±2℃
4 weeks later 실시예 4Example 4 9999 9898 101101 9393 9191 실시예 5Example 5 105105 102102 107107 9797 9999 실시예 6Example 6 9797 9393 9292 9999 9797 실시예 1Example 1 104104 103103 9797 100100 101101

표 21에서 실시예 1 및 4 내지 6의 SARS-CoV-2 RBD 결합 친화도는 모든 실험 조건에서 변화하지 않았으며 유사하였다. In Table 21, SARS-CoV-2 RBD binding affinities of Examples 1 and 4 to 6 were similar and did not change in all experimental conditions.

하기 표 22에서 크기배제 크로마토그래피 주성분 함량 (Main peak %) 측정 결과를 나타내었다.Table 22 below shows the measurement results of the main component content (Main peak %) by size exclusion chromatography.

　구분division 5±3℃
0일 후
(T=0)5±3℃
after 0 days
(T=0) 5±3℃
2주후5±3℃
After two weeks 40±2℃
2주후40±2℃
After two weeks 5±3℃
4주후5±3℃
4 weeks later 40±2℃
4주후40±2℃
4 weeks later 흔들림 스트레스shake stress 실시예 4Example 4 99.4499.44 99.4099.40 98.7498.74 99.3899.38 98.5798.57 99.4699.46 실시예 5Example 5 99.3599.35 99.3199.31 98.5598.55 99.2399.23 97.8497.84 99.3699.36 실시예 6Example 6 99.2999.29 99.1999.19 98.3998.39 99.0099.00 98.0798.07 99.2099.20 실시예 1Example 1 99.4899.48 99.4699.46 99.1199.11 99.5099.50 98.8398.83 99.4999.49

표 22를 보면 실시예 1 및 4 내지 6의 5±3℃ 조건에서의 주성분 함량은 99% 이상으로 안정함을 확인할 수 있었다. 그리고 40±2℃ 및 75±5% 상대 습도 조건에서 4주 후 주성분 함량은 97% 이상으로 안정함을 확인할 수 있었다. 흔들림 스트레스 조건에서 실시예 1 및 4 내지 6의 주성분 함량은 99% 이상으로 안정함을 확인할 수 있었다. Referring to Table 22, it was confirmed that the content of the main component in Examples 1 and 4 to 6 at 5±3° C. was stable at 99% or more. And it was confirmed that the main component content was stable at 97% or more after 4 weeks under the conditions of 40±2℃ and 75±5% relative humidity. It was confirmed that the main component content of Examples 1 and 4 to 6 was stable at 99% or more under shaking stress conditions.

하기 표 23에서 크기배제 크로마토그래피 고분자량 성분(pre-peak %) 측정 결과를 나타내었다.Table 23 below shows the measurement results of high molecular weight components (pre-peak %) by size exclusion chromatography.

　구분division 5±3℃
0일 후
(T=0)5±3℃
after 0 days
(T=0) 5±3℃
2주후5±3℃
After two weeks 40±2℃
2주후40±2℃
After two weeks 5±3℃
4주후5±3℃
4 weeks later 40±2℃
4주후40±2℃
4 weeks later 흔들림 스트레스shake stress 실시예 4Example 4 0.410.41 0.470.47 0.800.80 0.480.48 0.830.83 0.400.40 실시예 5Example 5 0.500.50 0.560.56 1.021.02 0.630.63 1.531.53 0.510.51 실시예 6Example 6 0.550.55 0.670.67 1.191.19 0.880.88 1.311.31 0.650.65 실시예 1Example 1 0.370.37 0.400.40 0.530.53 0.360.36 0.650.65 0.380.38

표 23을 보면 실시예 1 및 4 내지 6의 고분자량 성분 함량은 4주 후 5±3℃, 40±2℃ 및 75±5% 상대 습도 조건 그리고 흔들림 스트레스 조건에서 2.0% 이하임을 확인하였고, 단백질 농도가 가장 낮은 실시예 2의 고분자량 성분이 가장 낮았다. Referring to Table 23, it was confirmed that the high molecular weight component content of Examples 1 and 4 to 6 was 2.0% or less at 5±3° C., 40±2° C. and 75±5% relative humidity conditions and shaking stress after 4 weeks, and protein The high molecular weight component of Example 2, which had the lowest concentration, had the lowest concentration.

하기 표 24에서 크기배제 크로마토그래피 저분자량 성분(post-peak %) 측정 결과를 나타내었다.Table 24 below shows the results of measurement of low molecular weight components (post-peak %) by size exclusion chromatography.

　구분division 5±3℃
0일 후
(T=0)5±3℃
after 0 days
(T=0) 5±3℃
2주후5±3℃
After two weeks 40±2℃
2주후40±2℃
After two weeks 5±3℃
4주후5±3℃
4 weeks later 40±2℃
4주후40±2℃
4 weeks later 흔들림 스트레스shake stress 실시예 4Example 4 0.160.16 0.130.13 0.470.47 0.140.14 0.600.60 0.140.14 실시예 5Example 5 0.150.15 0.130.13 0.430.43 0.140.14 0.640.64 0.130.13 실시예 6Example 6 0.160.16 0.150.15 0.420.42 0.110.11 0.620.62 0.150.15 실시예 1Example 1 0.150.15 0.140.14 0.360.36 0.140.14 0.520.52 0.130.13

표 24에서 실시예 4 내지 6의 저분자량 성분 함량은 모든 조건에서 1.0% 이하임을 확인하였다. 모든 실시예의 저분자량 성분 함량은 실시예 1의 결과와 유사한 수준임을 알 수 있었다. In Table 24, it was confirmed that the low molecular weight component content of Examples 4 to 6 was 1.0% or less under all conditions. It can be seen that the content of low molecular weight components in all examples is at a level similar to that of Example 1.

하기 표 25에서 HIAC으로 측정한 불용성 이물 입자의 수(10.00≤(um)) 측정 결과를 나타내었다.Table 25 below shows the measurement results of the number of insoluble foreign particles (10.00≤(um)) measured by HIAC.

　구분division 5±3℃
0일 후
(T=0)5±3℃
after 0 days
(T=0) 5±3℃
2주후5±3℃
After two weeks 40±2℃
2주후40±2℃
After two weeks 5±3℃
4주후5±3℃
4 weeks later 40±2℃
4주후40±2℃
4 weeks later 흔들림 스트레스shake stress 실시예 4Example 4 88 1212 2020 1010 55 4040 실시예 5Example 5 3333 2525 3030 2727 3030 4343 실시예 6Example 6 3838 2222 143143 3535 6767 1212 실시예 1Example 1 00 55 3535 22 3535 9898

표 25와 같이 실시예 4 내지 6의 불용성 이물 입자(10.00≤(um))의 수는 모든 실험 조건에서 200개 이하로 안정적이며, 실시예 1의 결과와 유사한 수준임을 알 수 있었다. As shown in Table 25, the number of insoluble foreign particles (10.00≤(um)) of Examples 4 to 6 was stable to 200 or less under all experimental conditions, and it was found that the result was similar to the result of Example 1.

하기 표 26에서 HIAC으로 측정한 불용성 이물 입자의 수(25.00≤(um)) 측정 결과를 나타내었다.Table 26 below shows the measurement results of the number of insoluble foreign particles (25.00≤(um)) measured by HIAC.

　구분division 5±3℃
0일 후
(T=0)5±3℃
after 0 days
(T=0) 5±3℃
2주후5±3℃
After two weeks 40±2℃
2주후40±2℃
After two weeks 5±3℃
4주후5±3℃
4 weeks later 40±2℃
4주후40±2℃
4 weeks later 흔들림 스트레스shake stress 실시예 4Example 4 00 00 55 00 00 00 실시예 5Example 5 00 00 22 00 22 00 실시예 6Example 6 00 00 00 00 22 00 실시예 1Example 1 00 22 00 00 00 00

표 26과 같이 실시예 4 내지 6의 불용성 이물 입자(25.00≤(um))의 수는 모든 실험 조건에서 10개 이하로 안정적이며, 실시예 1의 결과와 유사한 수준임을 알 수 있었다. As shown in Table 26, the number of insoluble foreign particles (25.00≤(um)) of Examples 4 to 6 was stable to 10 or less under all experimental conditions, and it was found to be at a level similar to the result of Example 1.

하기 표 27에서 산화율 Oxidation (Met 263) 측정 결과를 나타내었다.Table 27 below shows the oxidation rate Oxidation (Met 263) measurement results.

　구분division 5±3℃
0일 후
(T=0)5±3℃
after 0 days
(T=0) 5±3℃
2주후5±3℃
After two weeks 40±2℃
2주후40±2℃
After two weeks 5±3℃
4주후5±3℃
4 weeks later 40±2℃
4주후40±2℃
4 weeks later 실시예 4Example 4 2.52.5 2.42.4 3.93.9 2.52.5 4.74.7 실시예 5Example 5 2.42.4 2.22.2 3.83.8 2.72.7 5.05.0 실시예 6Example 6 2.52.5 2.42.4 5.15.1 8.78.7 5.25.2 실시예 1Example 1 2.32.3 2.42.4 3.43.4 2.42.4 4.34.3

(단위: %)(unit: %)

표 27을 보면 실시예 4 내지 6의 산화율은 모든 조건에서 10% 이하로 안정적임을 알 수 있었다. Referring to Table 27, it could be seen that the oxidation rates of Examples 4 to 6 were stable at 10% or less under all conditions.

실험예 3: 완충제 농도, pH 범위, 안정화제 농도, 계면활성제 농도, 단백질 농도의 비교Experimental Example 3: Comparison of buffer concentration, pH range, stabilizer concentration, surfactant concentration, and protein concentration

실험예 3에서 사용된 약제학적 제제와 관련하여, 각 완충액을 각 pH에 맞게 제조한 뒤 아르기닌 모노하이드로클로라이드를 첨가하고, 이에 항체를 첨가 후 농축하였다. 그 후 계면활성제를 첨가하여 표 28의 시료들을 제조하였다. 실시예 1은 실험예 1에 따라 최종적으로 선정된 제제이다. 제조된 약학적 제제를 5±3℃ 온도와 25±2℃ 온도 및 60±5% 상대 습도 그리고 40±2℃ 온도 및 75±5% 상대 습도에서 보관하였고, 각 온도 조건에서 3주, 6주 및 9주간 후의 안정성을 측정하였다. 물리적 스트레스를 위해 상온 조건에서 3000 rpm으로 4시간의 흔들림 스트레스를 주었으며 얼림/녹임 스트레스는 -40℃ 조건에서 얼림과 녹임 5회 반복, 빛 스트레스는 가시광선 조도 1000 lux의 세기로 72시간 노출시켰다. 결과는 표 29 내지 43 및 도 10 내지 17에 나타내었다.With respect to the pharmaceutical formulation used in Experimental Example 3, each buffer was prepared to suit each pH, arginine monohydrochloride was added thereto, and the antibody was added thereto and then concentrated. After that, a surfactant was added to prepare the samples in Table 28. Example 1 is a formulation finally selected according to Experimental Example 1. The prepared pharmaceutical formulations were stored at 5±3°C temperature, 25±2°C temperature, 60±5% relative humidity, 40±2°C temperature and 75±5% relative humidity, and each temperature condition for 3 weeks and 6 weeks and stability after 9 weeks. For physical stress, shaking stress was applied at 3000 rpm at room temperature for 4 hours, freezing/thawing stress was repeated 5 times at -40 ° C. The results are shown in Tables 29 to 43 and FIGS. 10 to 17 .

본 실험예 3에서 사용된 항체는 상기 표 1 내지 표 2에 기재된 No. 139번 결합 분자이다.The antibody used in Experimental Example 3 was No. 1 described in Tables 1 to 2 above. 139 is the binding molecule.

구분division 완충제buffer pHpH 안정화제stabilizer 계면활성제Surfactants 단백질(항체)농도Protein (antibody) concentration 실시예 7Example 7 히스티딘 5 mMhistidine 5 mM 6.06.0 L-아르기닌
모노하이드로클로라이드 150 mML-Arginine
150 mM monohydrochloride 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 8Example 8 히스티딘 15 mMHistidine 15 mM 6.06.0 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 9Example 9 히스티딘 10 mMhistidine 10 mM 5.75.7 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 10Example 10 히스티딘 10 mMhistidine 10 mM 6.36.3 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 11Example 11 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌모노하이드로클로라이드 100 mML-Arginine monohydrochloride 100 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 12Example 12 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌모노하이드로클로라이드 200 mML-Arginine monohydrochloride 200 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 13Example 13 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.03% (w/v)Polysorbate 80
0.03% (w/v) 60
mg/mL60
mg/mL 실시예 14Example 14 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.07% (w/v)Polysorbate 80
0.07% (w/v) 60
mg/mL60
mg/mL 실시예 15Example 15 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 40
mg/mL40
mg/mL 실시예 16Example 16 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 80
mg/mL80
mg/mL 실시예 1Example 1 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL

하기 표 29에서 탁도 측정 결과를 나타내었다.The turbidity measurement results are shown in Table 29 below.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
3주 후after 3 weeks 25±2℃25±2℃
3주 후after 3 weeks 40±2℃40±2℃
3주 후after 3 weeks 5±3℃5±3℃
6주 후after 6 weeks 25±2℃25±2℃
6주 후after 6 weeks 40±2℃40±2℃
6주 후after 6 weeks 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 흔들림 shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 빛light
스트레스stress 실시예 7Example 7 0.01140.0114 0.00190.0019 0.00590.0059 0.00390.0039 0.01000.0100 0.00660.0066 0.00950.0095 0.00960.0096 0.00630.0063 0.01040.0104 0.00990.0099 0.01140.0114 0.01210.0121 실시예 8Example 8 0.01210.0121 0.01030.0103 0.00860.0086 0.00760.0076 0.00960.0096 0.01440.0144 0.00750.0075 0.00800.0080 0.00890.0089 0.01480.0148 0.00340.0034 0.01030.0103 0.02310.0231 실시예 9Example 9 0.00710.0071 0.00640.0064 0.00500.0050 0.00820.0082 0.01030.0103 0.00890.0089 0.00640.0064 0.01000.0100 0.01260.0126 0.00900.0090 0.00700.0070 0.01090.0109 0.01710.0171 실시예 10Example 10 0.00970.0097 0.00950.0095 0.00700.0070 0.00720.0072 0.01000.0100 0.01080.0108 0.00850.0085 0.01020.0102 0.00720.0072 0.01110.0111 0.00480.0048 0.00570.0057 0.00990.0099 실시예 11Example 11 0.01710.0171 0.00410.0041 0.00620.0062 0.01020.0102 0.01170.0117 0.01250.0125 0.00740.0074 0.00680.0068 0.01140.0114 0.00730.0073 0.00470.0047 0.00890.0089 0.01180.0118 실시예 12Example 12 0.01560.0156 0.00440.0044 0.00610.0061 0.00970.0097 0.01050.0105 0.00720.0072 0.00680.0068 0.00750.0075 0.01050.0105 0.01120.0112 0.00270.0027 0.00650.0065 0.00890.0089 실시예 13Example 13 0.00670.0067 0.00640.0064 0.00440.0044 0.01240.0124 0.01510.0151 0.00630.0063 0.00780.0078 0.00720.0072 0.00690.0069 0.00830.0083 0.00810.0081 0.00770.0077 0.01620.0162 실시예 14Example 14 0.00590.0059 0.00600.0060 0.00660.0066 0.00390.0039 0.00690.0069 0.01060.0106 0.01120.0112 0.00800.0080 0.00930.0093 0.00920.0092 0.00420.0042 0.00660.0066 0.00930.0093 실시예 15Example 15 0.00400.0040 0.00710.0071 0.00630.0063 0.00300.0030 0.00610.0061 0.00590.0059 0.00540.0054 0.00420.0042 0.00430.0043 0.00510.0051 0.00670.0067 0.00470.0047 0.02130.0213 실시예 16Example 16 0.00530.0053 0.00720.0072 0.00730.0073 0.00430.0043 0.01030.0103 0.00870.0087 0.01340.0134 0.01200.0120 0.00800.0080 0.00850.0085 0.01280.0128 0.00700.0070 0.01500.0150 실시예 1Example 1 0.00660.0066 0.00990.0099 0.00420.0042 0.00550.0055 0.01070.0107 0.00860.0086 0.00830.0083 0.00660.0066 0.01650.0165 0.00900.0090 0.00360.0036 0.00990.0099 0.01960.0196

표 29를 보면, 실시예 7 내지 16의 탁도는 모든 조건에서 0.0400이하로 안정적이며, 실시예 1과 차이가 없는 것을 알 수 있었다. Looking at Table 29, it can be seen that the turbidity of Examples 7 to 16 is stable at 0.0400 or less under all conditions, and there is no difference from Example 1.

하기 표 30에서 크기배제 크로마토그래피 주성분 함량 (Main peak %) 측정 결과를 나타내었다.Table 30 below shows the measurement results of the main component content (Main peak %) by size exclusion chromatography.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
3주 후after 3 weeks 25±2℃25±2℃
3주 후after 3 weeks 40±2℃40±2℃
3주 후after 3 weeks 5±3℃5±3℃
6주 후after 6 weeks 25±2℃25±2℃
6주 후after 6 weeks 40±2℃40±2℃
6주 후after 6 weeks 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 흔들림 shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 빛light
스트레스stress 실시예 7Example 7 99.4799.47 99.5099.50 99.3699.36 98.9698.96 99.4499.44 99.2899.28 98.5398.53 99.4299.42 99.1999.19 98.2498.24 99.4699.46 99.3999.39 99.1299.12 실시예 8Example 8 99.4599.45 99.5399.53 99.4199.41 98.9998.99 99.4499.44 99.2999.29 98.5498.54 99.4599.45 99.1499.14 98.2098.20 99.4899.48 99.4399.43 99.0999.09 실시예 9Example 9 99.5399.53 99.5499.54 99.4699.46 98.7698.76 99.4599.45 99.3699.36 98.4598.45 99.4799.47 99.1599.15 97.8297.82 99.2999.29 99.4699.46 99.1999.19 실시예 10Example 10 99.2699.26 99.4699.46 99.2999.29 98.8798.87 99.3799.37 99.1499.14 98.4398.43 99.3899.38 99.0599.05 98.0998.09 99.4099.40 99.3099.30 99.1599.15 실시예 11Example 11 99.3799.37 99.4799.47 99.3499.34 98.9098.90 99.4499.44 99.2599.25 98.5098.50 99.4499.44 99.1599.15 98.1798.17 99.4599.45 99.3699.36 99.1599.15 실시예 12Example 12 99.4599.45 99.4999.49 99.4299.42 98.9498.94 99.4699.46 99.2999.29 98.5398.53 99.4499.44 99.2199.21 98.1998.19 99.4999.49 99.4199.41 99.1799.17 실시예 13Example 13 99.4899.48 99.4599.45 99.3999.39 98.9698.96 99.4299.42 99.2899.28 98.5298.52 99.3799.37 99.1999.19 98.1998.19 99.4299.42 99.4199.41 99.0899.08 실시예 14Example 14 99.4799.47 99.5099.50 99.3799.37 98.9498.94 99.4599.45 99.2899.28 98.5298.52 99.4299.42 99.1199.11 98.2198.21 99.4199.41 99.4099.40 99.0899.08 실시예 15Example 15 99.4899.48 99.3899.38 99.3899.38 98.9598.95 99.5099.50 99.3899.38 98.6898.68 99.4199.41 99.2899.28 98.3598.35 99.4899.48 99.4599.45 99.2699.26 실시예 16Example 16 99.3799.37 99.3099.30 99.2599.25 98.7098.70 99.3999.39 99.1899.18 98.3798.37 99.3999.39 99.0699.06 98.1198.11 99.4699.46 99.3799.37 98.9998.99 실시예 1Example 1 99.4799.47 99.4599.45 99.3999.39 98.9798.97 99.4399.43 99.2399.23 98.5598.55 99.3799.37 99.1899.18 98.2398.23 99.3899.38 99.3899.38 98.9198.91

표 30과 같이 실시예 7 내지 16의 주성분 함량은 5±3℃ 온도 조건에서 99% 이상으로 안정적이며, 40±2℃ 온도 및 75±5% 상대 습도 조건에서 97% 이상으로 안정적임을 알 수 있었다. 또한 실시예 1의 결과와 유사한 수준임을 알 수 있었다 (도 10, 도 11 및 12).As shown in Table 30, it was found that the main component content of Examples 7 to 16 was stable to 99% or more at 5±3° C. temperature conditions, and was stable to 97% or more at 40±2° C. temperature and 75±5% relative humidity conditions. . It was also found that the level was similar to that of Example 1 ( FIGS. 10 , 11 and 12 ).

하기 표 31에서 크기배제 크로마토그래피 고분자량 성분(pre-peak %) 측정 결과를 나타내었다.Table 31 below shows the measurement results of high molecular weight components (pre-peak %) by size exclusion chromatography.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
3주 후after 3 weeks 25±2℃25±2℃
3주 후after 3 weeks 40±2℃40±2℃
3주 후after 3 weeks 5±3℃5±3℃
6주 후after 6 weeks 25±2℃25±2℃
6주 후after 6 weeks 40±2℃40±2℃
6주 후after 6 weeks 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 흔들림 shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 빛light
스트레스stress 실시예 7Example 7 0.480.48 0.450.45 0.530.53 0.680.68 0.510.51 0.600.60 0.850.85 0.520.52 0.610.61 0.810.81 0.470.47 0.570.57 0.790.79 실시예 8Example 8 0.480.48 0.410.41 0.490.49 0.630.63 0.510.51 0.590.59 0.820.82 0.460.46 0.650.65 0.800.80 0.440.44 0.530.53 0.820.82 실시예 9Example 9 0.410.41 0.400.40 0.450.45 0.660.66 0.500.50 0.520.52 0.780.78 0.460.46 0.630.63 0.890.89 0.640.64 0.500.50 0.680.68 실시예 10Example 10 0.660.66 0.490.49 0.600.60 0.770.77 0.590.59 0.730.73 0.970.97 0.550.55 0.740.74 0.930.93 0.520.52 0.660.66 0.750.75 실시예 11Example 11 0.570.57 0.470.47 0.550.55 0.710.71 0.520.52 0.630.63 0.880.88 0.490.49 0.640.64 0.870.87 0.470.47 0.590.59 0.740.74 실시예 12Example 12 0.490.49 0.450.45 0.490.49 0.670.67 0.490.49 0.580.58 0.850.85 0.470.47 0.580.58 0.810.81 0.440.44 0.540.54 0.720.72 실시예 13Example 13 0.460.46 0.490.49 0.520.52 0.680.68 0.540.54 0.600.60 0.850.85 0.530.53 0.620.62 0.830.83 0.500.50 0.540.54 0.790.79 실시예 14Example 14 0.460.46 0.450.45 0.520.52 0.700.70 0.520.52 0.600.60 0.870.87 0.510.51 0.680.68 0.840.84 0.520.52 0.570.57 0.800.80 실시예 15Example 15 0.460.46 0.510.51 0.470.47 0.610.61 0.460.46 0.510.51 0.690.69 0.500.50 0.540.54 0.730.73 0.440.44 0.510.51 0.650.65 실시예 16Example 16 0.540.54 0.590.59 0.570.57 0.800.80 0.560.56 0.700.70 1.011.01 0.550.55 0.730.73 0.950.95 0.480.48 0.580.58 0.910.91 실시예 1Example 1 0.470.47 0.500.50 0.510.51 0.660.66 0.520.52 0.640.64 0.830.83 0.520.52 0.630.63 0.810.81 0.530.53 0.570.57 0.840.84

표 31과 같이 실시예 7 내지 16의 고분자량 성분 함량은 5±3℃ 온도 조건에서 1.0% 이하로 안정적이며, 40±2℃ 온도 및 75±5% 상대 습도 조건에서 2.0% 이하로 안정적임을 알 수 있었다. 또한 실시예 1의 결과와 유사한 수준임을 알 수 있었다. As shown in Table 31, the high molecular weight component content of Examples 7 to 16 is stable to 1.0% or less at 5±3° C. temperature conditions, and is stable to 2.0% or less at 40±2° C. temperature and 75±5% relative humidity conditions. could In addition, it was found that the level was similar to the result of Example 1.

하기 표 32에서 크기배제 크로마토그래피 저분자량 성분(post-peak %) 측정 결과를 나타내었다.Table 32 below shows the measurement results of low molecular weight components (post-peak %) by size exclusion chromatography.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
3주 후after 3 weeks 25±2℃25±2℃
3주 후after 3 weeks 40±2℃40±2℃
3주 후after 3 weeks 5±3℃5±3℃
6주 후after 6 weeks 25±2℃25±2℃
6주 후after 6 weeks 40±2℃40±2℃
6주 후after 6 weeks 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 흔들림 shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 빛light
스트레스stress 실시예 7Example 7 0.050.05 0.050.05 0.120.12 0.370.37 0.040.04 0.120.12 0.620.62 0.050.05 0.200.20 0.960.96 0.070.07 0.040.04 0.090.09 실시예 8Example 8 0.070.07 0.060.06 0.100.10 0.370.37 0.050.05 0.120.12 0.640.64 0.100.10 0.210.21 0.990.99 0.080.08 0.050.05 0.090.09 실시예 9Example 9 0.060.06 0.060.06 0.090.09 0.580.58 0.050.05 0.120.12 0.770.77 0.060.06 0.220.22 1.291.29 0.070.07 0.040.04 0.130.13 실시예 10Example 10 0.070.07 0.050.05 0.110.11 0.360.36 0.050.05 0.130.13 0.600.60 0.080.08 0.210.21 0.990.99 0.080.08 0.040.04 0.100.10 실시예 11Example 11 0.060.06 0.060.06 0.110.11 0.390.39 0.040.04 0.120.12 0.620.62 0.070.07 0.210.21 0.950.95 0.080.08 0.060.06 0.110.11 실시예 12Example 12 0.070.07 0.050.05 0.090.09 0.380.38 0.040.04 0.120.12 0.630.63 0.090.09 0.200.20 1.001.00 0.080.08 0.050.05 0.110.11 실시예 13Example 13 0.060.06 0.060.06 0.100.10 0.370.37 0.040.04 0.120.12 0.620.62 0.100.10 0.190.19 0.980.98 0.070.07 0.050.05 0.140.14 실시예 14Example 14 0.080.08 0.050.05 0.100.10 0.360.36 0.040.04 0.120.12 0.610.61 0.070.07 0.210.21 0.950.95 0.070.07 0.040.04 0.120.12 실시예 15Example 15 0.060.06 0.120.12 0.150.15 0.430.43 0.040.04 0.120.12 0.620.62 0.080.08 0.180.18 0.920.92 0.080.08 0.040.04 0.090.09 실시예 16Example 16 0.100.10 0.120.12 0.180.18 0.500.50 0.040.04 0.120.12 0.630.63 0.070.07 0.210.21 0.950.95 0.060.06 0.050.05 0.110.11 실시예 1Example 1 0.060.06 0.060.06 0.110.11 0.370.37 0.050.05 0.140.14 0.620.62 0.110.11 0.190.19 0.960.96 0.090.09 0.040.04 0.240.24

표 32와 같이 실시예 7 내지 16의 저분자량 성분 함량은 5±3℃ 온도 조건에서 0.5% 이하로 안정적이며, 40±2℃ 온도 및 75±5% 상대 습도 조건에서 1.5% 이하로 안정적임을 알 수 있었다. 또한 실시예 1의 결과와 유사한 수준임을 알 수 있었다. As shown in Table 32, it can be seen that the low molecular weight component content of Examples 7 to 16 is stable to 0.5% or less at 5±3° C. temperature conditions, and is stable to 1.5% or less at 40±2° C. temperature and 75±5% relative humidity conditions. could In addition, it was found that the level was similar to the result of Example 1.

하기 표 33에서 온전한 면역 글로불린G의 함량 (비환원 chip-based CE-SDS) 측정 결과를 나타내었다.Table 33 below shows the measurement results of the intact immunoglobulin G content (non-reducing chip-based CE-SDS).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
3주 후after 3 weeks 25±2℃25±2℃
3주 후after 3 weeks 40±2℃40±2℃
3주 후after 3 weeks 5±3℃5±3℃
6주 후after 6 weeks 25±2℃25±2℃
6주 후after 6 weeks 40±2℃40±2℃
6주 후after 6 weeks 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 흔들림 shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 빛light
스트레스stress 실시예 7Example 7 98.1598.15 97.8697.86 98.0998.09 97.8097.80 98.4198.41 98.6998.69 98.6798.67 97.5297.52 97.5097.50 96.5996.59 97.8697.86 98.7798.77 98.6298.62 실시예 8Example 8 98.1798.17 97.9097.90 97.9097.90 97.6897.68 98.4398.43 98.7498.74 98.7598.75 97.6197.61 97.3297.32 96.5896.58 97.7497.74 98.9598.95 98.8098.80 실시예 9Example 9 98.2498.24 97.9997.99 97.4697.46 97.4697.46 98.4398.43 98.7798.77 98.6898.68 97.6297.62 97.5297.52 96.2596.25 97.7497.74 98.9198.91 98.5998.59 실시예 10Example 10 98.2298.22 98.0198.01 98.0498.04 97.6197.61 98.4098.40 98.6398.63 98.6398.63 97.6297.62 97.3897.38 96.3796.37 97.9697.96 98.8798.87 98.2298.22 실시예 11Example 11 98.1998.19 98.0998.09 97.9397.93 97.7297.72 98.3398.33 98.8098.80 98.7598.75 97.5197.51 97.3897.38 96.5496.54 97.8297.82 98.9598.95 98.7598.75 실시예 12Example 12 98.2598.25 97.8497.84 97.9897.98 97.5097.50 98.3298.32 98.7498.74 98.7198.71 97.5797.57 97.4697.46 96.6096.60 97.8497.84 98.8598.85 98.7398.73 실시예 13Example 13 98.2198.21 97.5997.59 97.8497.84 97.5497.54 98.3898.38 98.6898.68 98.7198.71 97.5197.51 97.2597.25 96.3796.37 97.9397.93 98.8798.87 98.5998.59 실시예 14Example 14 98.2198.21 97.6797.67 97.7297.72 97.5497.54 98.4398.43 98.6498.64 98.6398.63 97.4697.46 97.4097.40 96.4496.44 97.9897.98 98.8098.80 98.4798.47 실시예 15Example 15 98.2698.26 97.8597.85 98.0998.09 97.6497.64 98.3898.38 98.6398.63 98.7298.72 97.5097.50 97.3597.35 96.9896.98 97.8797.87 99.0099.00 98.7298.72 실시예 16Example 16 98.2698.26 97.9597.95 97.3997.39 97.4397.43 98.3398.33 98.7498.74 98.6798.67 97.4697.46 97.4897.48 96.1396.13 97.6797.67 98.8898.88 98.7698.76 실시예 1Example 1 98.1598.15 97.8997.89 97.8697.86 97.8697.86 98.4498.44 98.7798.77 98.7498.74 97.6097.60 97.4697.46 96.6096.60 97.8397.83 98.9198.91 98.6398.63

(단위: %)(unit: %)

표 33에서 보듯이, 실시예 7 내지 16의 온전한 면역 글로불린G의 함량은 모든 조건에서 실시예 1의 결과와 유사한 수준임을 알 수 있었다 (도 13).As shown in Table 33, it was found that the intact immunoglobulin G content of Examples 7 to 16 was at a level similar to that of Example 1 under all conditions (FIG. 13).

하기 표 34에서 항체 경쇄와 중쇄의 함량 (환원 chip-based CE-SDS) 측정 결과를 나타내었다.Table 34 below shows the measurement results of the antibody light chain and heavy chain content (reduced chip-based CE-SDS).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
3주 후after 3 weeks 25±2℃25±2℃
3주 후after 3 weeks 40±2℃40±2℃
3주 후after 3 weeks 5±3℃5±3℃
6주 후after 6 weeks 25±2℃25±2℃
6주 후after 6 weeks 40±2℃40±2℃
6주 후after 6 weeks 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 흔들림 shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 빛light
스트레스stress 실시예 7Example 7 99.7599.75 99.6399.63 99.6099.60 99.3399.33 99.6899.68 99.6699.66 99.6199.61 99.7399.73 99.5299.52 99.0399.03 99.7099.70 99.7999.79 99.5799.57 실시예 8Example 8 99.7499.74 99.6099.60 99.5299.52 99.3399.33 99.6899.68 99.6099.60 99.5899.58 99.6199.61 99.5499.54 99.0199.01 99.7099.70 99.8199.81 99.6699.66 실시예 9Example 9 99.7599.75 99.5899.58 99.6899.68 99.4199.41 99.6999.69 99.5799.57 99.5699.56 99.6499.64 99.6099.60 99.1099.10 99.6899.68 99.8099.80 99.5099.50 실시예 10Example 10 99.7499.74 99.6799.67 99.5099.50 99.3699.36 99.7099.70 99.4999.49 99.5499.54 99.6399.63 99.5599.55 98.9198.91 99.6999.69 99.7999.79 99.5499.54 실시예 11Example 11 99.7499.74 99.6499.64 99.5799.57 99.3999.39 99.7099.70 99.5299.52 99.6199.61 99.6599.65 99.5799.57 99.0299.02 99.6699.66 99.8199.81 99.6599.65 실시예 12Example 12 99.7399.73 99.7299.72 99.5599.55 99.4099.40 99.6499.64 99.5599.55 99.6199.61 99.6299.62 99.5199.51 99.0799.07 99.7099.70 99.8099.80 99.5599.55 실시예 13Example 13 99.7299.72 99.5399.53 99.5899.58 99.3599.35 99.6999.69 99.5699.56 99.5999.59 99.6099.60 99.5599.55 99.0199.01 99.6699.66 99.8099.80 99.5899.58 실시예 14Example 14 99.7299.72 99.6699.66 99.5499.54 99.2999.29 99.6999.69 99.5499.54 99.5999.59 99.6599.65 99.5499.54 99.0799.07 99.6999.69 99.8099.80 99.6199.61 실시예 15Example 15 99.7099.70 99.6199.61 99.5999.59 99.2699.26 99.6899.68 99.5399.53 99.6099.60 99.6499.64 99.5399.53 99.0299.02 99.6699.66 99.8199.81 99.5199.51 실시예 16Example 16 99.7199.71 99.2299.22 99.4499.44 99.3599.35 99.7199.71 99.5699.56 99.5999.59 99.6399.63 99.5399.53 99.0699.06 99.6799.67 99.8199.81 99.4899.48 실시예 1Example 1 99.7299.72 99.5599.55 99.4999.49 99.3699.36 99.7199.71 99.5699.56 99.6099.60 99.6699.66 99.5599.55 99.0399.03 99.6899.68 99.8199.81 99.5999.59

(단위: %)(unit: %)

표 34에서 보듯이, 실시예 7 내지 16의 항체 경쇄와 중쇄의 함량은 모든 조건에서 실시예 1의 결과와 유사한 수준임을 알 수 있었다 (도 14).As shown in Table 34, the content of the antibody light chain and heavy chain of Examples 7 to 16 was found to be at a level similar to the result of Example 1 under all conditions (FIG. 14).

하기 표 35에서 전하 변형체 (메인 피크 %) 측정 결과를 나타내었다.Table 35 below shows the measurement results of the charge variant (main peak %).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
3주 후after 3 weeks 25±2℃25±2℃
3주 후after 3 weeks 40±2℃40±2℃
3주 후after 3 weeks 5±3℃5±3℃
6주 후after 6 weeks 25±2℃25±2℃
6주 후after 6 weeks 40±2℃40±2℃
6주 후after 6 weeks 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 흔들림 shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 빛light
스트레스stress 실시예 7Example 7 62.29 62.29 62.36 62.36 62.29 62.29 57.88 57.88 63.32 63.32 62.39 62.39 54.34 54.34 62.61 62.61 62.06 62.06 50.73 50.73 61.53 61.53 63.01 63.01 61.81 61.81 실시예 8Example 8 62.34 62.34 62.61 62.61 62.52 62.52 58.48 58.48 63.37 63.37 63.00 63.00 54.59 54.59 62.91 62.91 63.12 63.12 49.88 49.88 61.51 61.51 63.07 63.07 61.81 61.81 실시예 9Example 9 62.33 62.33 62.62 62.62 62.03 62.03 57.44 57.44 62.97 62.97 62.12 62.12 52.83 52.83 62.53 62.53 62.34 62.34 49.59 49.59 61.50 61.50 63.07 63.07 61.91 61.91 실시예 10Example 10 61.52 61.52 62.45 62.45 62.25 62.25 58.87 58.87 62.98 62.98 63.11 63.11 54.95 54.95 62.59 62.59 62.81 62.81 50.84 50.84 61.65 61.65 63.14 63.14 61.27 61.27 실시예 11Example 11 61.46 61.46 62.30 62.30 62.16 62.16 58.15 58.15 62.92 62.92 62.83 62.83 54.32 54.32 62.61 62.61 62.70 62.70 50.25 50.25 61.43 61.43 62.44 62.44 61.72 61.72 실시예 12Example 12 61.48 61.48 62.45 62.45 62.32 62.32 58.67 58.67 62.95 62.95 62.65 62.65 54.95 54.95 62.81 62.81 62.61 62.61 50.87 50.87 61.43 61.43 63.19 63.19 61.72 61.72 실시예 13Example 13 61.56 61.56 62.29 62.29 62.30 62.30 58.38 58.38 62.80 62.80 62.49 62.49 54.71 54.71 62.90 62.90 62.82 62.82 50.80 50.80 61.41 61.41 63.20 63.20 61.60 61.60 실시예 14Example 14 61.64 61.64 62.35 62.35 62.36 62.36 58.52 58.52 62.98 62.98 62.65 62.65 54.67 54.67 62.82 62.82 62.84 62.84 51.03 51.03 61.99 61.99 63.18 63.18 61.81 61.81 실시예 15Example 15 61.54 61.54 60.68 60.68 61.79 61.79 57.83 57.83 63.10 63.10 62.31 62.31 54.56 54.56 62.82 62.82 62.59 62.59 50.57 50.57 61.53 61.53 63.21 63.21 62.08 62.08 실시예 16Example 16 61.56 61.56 62.10 62.10 62.25 62.25 58.21 58.21 62.87 62.87 62.36 62.36 55.00 55.00 62.82 62.82 62.76 62.76 50.65 50.65 61.59 61.59 63.46 63.46 61.59 61.59 실시예 1Example 1 61.67 61.67 62.55 62.55 62.44 62.44 58.44 58.44 62.98 62.98 62.74 62.74 54.48 54.48 62.65 62.65 62.68 62.68 50.47 50.47 61.74 61.74 62.93 62.93 61.91 61.91

표 35에서 보듯이, 실시예 7 내지 16의 전하 변형체 (메인 피크) 함량은 모든 조건에서 실시예 1의 결과와 유사한 수준임을 알 수 있었다 (도 15).As shown in Table 35, it was found that the contents of the charge variants (main peak) of Examples 7 to 16 were similar to the results of Example 1 under all conditions ( FIG. 15 ).

하기 표 36에서 전하 변형체 (산성 피크 %) 측정 결과를 나타내었다.Table 36 below shows the measurement results of the charge variant (acid peak %).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
3주 후after 3 weeks 25±2℃25±2℃
3주 후after 3 weeks 40±2℃40±2℃
3주 후after 3 weeks 5±3℃5±3℃
6주 후after 6 weeks 25±2℃25±2℃
6주 후after 6 weeks 40±2℃40±2℃
6주 후after 6 weeks 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 흔들림 shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 빛light
스트레스stress 실시예 7Example 7 14.06 14.06 14.27 14.27 14.70 14.70 20.71 20.71 13.57 13.57 15.38 15.38 28.31 28.31 14.12 14.12 15.87 15.87 32.85 32.85 14.36 14.36 14.12 14.12 15.06 15.06 실시예 8Example 8 14.13 14.13 14.12 14.12 14.95 14.95 21.54 21.54 13.68 13.68 15.66 15.66 29.11 29.11 14.16 14.16 15.82 15.82 34.29 34.29 14.48 14.48 14.22 14.22 15.12 15.12 실시예 9Example 9 14.08 14.08 13.97 13.97 14.75 14.75 21.37 21.37 13.91 13.91 15.49 15.49 29.22 29.22 14.11 14.11 15.64 15.64 34.21 34.21 14.48 14.48 13.87 13.87 14.50 14.50 실시예 10Example 10 14.28 14.28 14.33 14.33 15.35 15.35 22.06 22.06 14.16 14.16 15.83 15.83 29.44 29.44 14.33 14.33 16.50 16.50 33.97 33.97 14.57 14.57 14.27 14.27 16.12 16.12 실시예 11Example 11 14.36 14.36 14.41 14.41 15.07 15.07 21.62 21.62 14.16 14.16 15.65 15.65 29.11 29.11 14.20 14.20 15.74 15.74 33.90 33.90 14.75 14.75 15.07 15.07 15.08 15.08 실시예 12Example 12 14.35 14.35 14.28 14.28 14.89 14.89 21.06 21.06 14.15 14.15 15.61 15.61 28.20 28.20 14.01 14.01 15.69 15.69 32.92 32.92 14.48 14.48 13.98 13.98 14.93 14.93 실시예 13Example 13 14.42 14.42 14.36 14.36 15.04 15.04 21.45 21.45 14.22 14.22 15.98 15.98 28.61 28.61 13.98 13.98 15.76 15.76 33.07 33.07 14.58 14.58 14.06 14.06 15.20 15.20 실시예 14Example 14 14.85 14.85 14.36 14.36 14.95 14.95 21.40 21.40 14.19 14.19 15.96 15.96 28.65 28.65 14.07 14.07 15.69 15.69 33.15 33.15 15.07 15.07 14.04 14.04 15.01 15.01 실시예 15Example 15 14.42 14.42 16.27 16.27 15.32 15.32 22.04 22.04 14.08 14.08 16.07 16.07 28.53 28.53 14.14 14.14 15.54 15.54 33.47 33.47 14.53 14.53 13.95 13.95 14.83 14.83 실시예 16Example 16 14.35 14.35 14.68 14.68 15.15 15.15 22.03 22.03 14.25 14.25 16.33 16.33 28.58 28.58 14.13 14.13 15.88 15.88 33.34 33.34 14.49 14.49 13.74 13.74 15.17 15.17 실시예 1Example 1 14.13 14.13 14.17 14.17 14.81 14.81 21.20 21.20 14.02 14.02 15.72 15.72 28.94 28.94 14.16 14.16 15.75 15.75 33.64 33.64 14.33 14.33 14.15 14.15 15.23 15.23

표 36에서 보듯이, 실시예 7 내지 16의 전하 변형체 (산성 피크) 함량은 모든 조건에서 실시예 1의 결과와 유사한 수준임을 알 수 있었다 (도 16).As shown in Table 36, it was found that the contents of the charge variants (acid peak) of Examples 7 to 16 were similar to the results of Example 1 under all conditions ( FIG. 16 ).

하기 표 37에서 전하 변형체 (염기성 피크 %) 측정 결과를 나타내었다.Table 37 below shows the measurement results of charge variants (basic peak %).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
3주 후after 3 weeks 25±2℃25±2℃
3주 후after 3 weeks 40±2℃40±2℃
3주 후after 3 weeks 5±3℃5±3℃
6주 후after 6 weeks 25±2℃25±2℃
6주 후after 6 weeks 40±2℃40±2℃
6주 후after 6 weeks 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 흔들림 shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 빛light
스트레스stress 실시예 7Example 7 23.66 23.66 23.37 23.37 23.01 23.01 21.41 21.41 23.10 23.10 22.23 22.23 17.36 17.36 23.26 23.26 22.08 22.08 16.42 16.42 24.11 24.11 22.86 22.86 23.13 23.13 실시예 8Example 8 23.53 23.53 23.27 23.27 22.53 22.53 19.99 19.99 22.95 22.95 21.34 21.34 16.30 16.30 22.93 22.93 21.06 21.06 15.83 15.83 24.02 24.02 22.71 22.71 23.09 23.09 실시예 9Example 9 23.58 23.58 23.41 23.41 23.22 23.22 21.18 21.18 23.12 23.12 22.39 22.39 17.94 17.94 23.36 23.36 22.02 22.02 16.19 16.19 24.01 24.01 23.07 23.07 23.59 23.59 실시예 10Example 10 24.20 24.20 23.21 23.21 22.41 22.41 19.07 19.07 22.86 22.86 21.06 21.06 15.61 15.61 23.07 23.07 20.69 20.69 15.18 15.18 23.78 23.78 22.59 22.59 22.62 22.62 실시예 11Example 11 24.18 24.18 23.29 23.29 22.77 22.77 20.24 20.24 22.92 22.92 21.53 21.53 16.57 16.57 23.19 23.19 21.57 21.57 15.85 15.85 23.83 23.83 22.47 22.47 23.21 23.21 실시예 12Example 12 24.16 24.16 23.27 23.27 22.79 22.79 20.28 20.28 22.89 22.89 21.74 21.74 16.85 16.85 23.18 23.18 21.69 21.69 16.20 16.20 24.09 24.09 22.83 22.83 23.35 23.35 실시예 13Example 13 24.03 24.03 23.36 23.36 22.66 22.66 20.17 20.17 22.98 22.98 21.53 21.53 16.68 16.68 23.12 23.12 21.41 21.41 16.13 16.13 24.02 24.02 22.74 22.74 23.19 23.19 실시예 14Example 14 23.50 23.50 23.29 23.29 22.69 22.69 20.09 20.09 22.84 22.84 21.38 21.38 16.68 16.68 23.11 23.11 21.47 21.47 15.82 15.82 22.94 22.94 22.78 22.78 23.18 23.18 실시예 15Example 15 24.05 24.05 23.01 23.01 22.88 22.88 20.12 20.12 22.82 22.82 21.63 21.63 16.91 16.91 23.04 23.04 21.86 21.86 15.96 15.96 23.95 23.95 22.85 22.85 23.10 23.10 실시예 16Example 16 24.10 24.10 23.22 23.22 22.61 22.61 19.75 19.75 22.89 22.89 21.30 21.30 16.41 16.41 23.04 23.04 21.36 21.36 16.01 16.01 23.92 23.92 22.80 22.80 23.24 23.24 실시예 1Example 1 24.19 24.19 23.28 23.28 22.76 22.76 20.36 20.36 22.99 22.99 21.53 21.53 16.58 16.58 23.19 23.19 21.58 21.58 15.89 15.89 23.93 23.93 22.91 22.91 22.86 22.86

표 37에서 보듯이, 실시예 7 내지 16의 전하 변형체 (염기성 피크) 함량은 모든 조건에서 실시예 1의 결과와 유사한 수준임을 알 수 있었다 (도 17).As shown in Table 37, it was found that the contents of the charge variants (basic peak) of Examples 7 to 16 were similar to the results of Example 1 under all conditions (FIG. 17).

하기 표 38에서 산화율 Oxidation (Met 263) 측정 결과를 나타내었다.Table 38 below shows the oxidation rate Oxidation (Met 263) measurement results.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 빛light
스트레스stress 실시예 7Example 7 2.42.4 2.72.7 3.43.4 6.86.8 4.44.4 실시예 8Example 8 2.72.7 2.82.8 3.43.4 7.07.0 4.94.9 실시예 9Example 9 2.42.4 2.52.5 2.72.7 4.44.4 4.44.4 실시예 10Example 10 2.42.4 2.82.8 3.93.9 8.48.4 4.84.8 실시예 11Example 11 2.32.3 3.53.5 3.33.3 7.57.5 5.35.3 실시예 12Example 12 2.32.3 2.72.7 5.45.4 8.38.3 5.05.0 실시예 13Example 13 2.42.4 2.72.7 4.74.7 8.08.0 5.15.1 실시예 14Example 14 2.42.4 2.82.8 3.83.8 7.77.7 4.54.5 실시예 15Example 15 2.42.4 2.82.8 3.73.7 7.97.9 4.34.3 실시예 16Example 16 2.42.4 2.82.8 4.04.0 8.48.4 5.25.2 실시예 1Example 1 2.42.4 2.72.7 3.53.5 6.86.8 4.94.9

(단위: %)(unit: %)

표 38에서 실시예 7 내지 16의 산화율은 모든 조건에서 실시예 1의 결과와 유사한 수준임을 알 수 있었다. In Table 38, it can be seen that the oxidation rates of Examples 7 to 16 are at a level similar to the results of Example 1 under all conditions.

하기 표 39에서 SARS-CoV-2 RBD 결합 친화도 (ELISA) 측정 결과를 나타내었다.Table 39 below shows the measurement results of SARS-CoV-2 RBD binding affinity (ELISA).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
3주 후after 3 weeks 25±2℃25±2℃
3주 후after 3 weeks 40±2℃40±2℃
3주 후after 3 weeks 5±3℃5±3℃
6주 후after 6 weeks 25±2℃25±2℃
6주 후after 6 weeks 40±2℃40±2℃
6주 후after 6 weeks 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 빛light
스트레스stress 실시예 7Example 7 101101 9999 9898 9797 106106 9494 9696 108108 102102 105105 107107 실시예 8Example 8 100100 9797 106106 9595 104104 9696 101101 100100 105105 102102 107107 실시예 9Example 9 104104 107107 103103 9898 106106 105105 9494 107107 112112 114114 100100 실시예 10Example 10 101101 102102 9898 101101 9696 9696 9999 9898 107107 104104 106106 실시예 11Example 11 104104 100100 106106 101101 101101 9999 9999 103103 9999 9898 102102 실시예 12Example 12 9797 100100 102102 101101 9999 105105 9999 108108 107107 113113 9797 실시예 13Example 13 111111 9494 110110 9898 106106 9696 9696 113113 103103 104104 9999 실시예 14Example 14 108108 106106 106106 102102 104104 8686 101101 100100 9898 9898 104104 실시예 15Example 15 103103 109109 118118 9797 108108 9393 9696 103103 100100 113113 110110 실시예 16Example 16 109109 101101 9090 9191 100100 9292 109109 9999 101101 108108 107107 실시예 1Example 1 100100 102102 9797 102102 100100 101101 106106 103103 9797 100100 110110

표 39에서 실시예 7 내지 16의 SARS-CoV-2 RBD 결합 친화도는 모든 조건에서 실시예 1의 결과와 유사한 수준임을 알 수 있었다. In Table 39, it can be seen that the SARS-CoV-2 RBD binding affinity of Examples 7 to 16 is at a level similar to that of Example 1 under all conditions.

하기 표 40에서 MFI 로 측정한 불용성 이물 입자의 수(10.00㎛≤, <100.00㎛) 측정 결과를 나타내었다.Table 40 below shows the measurement results of the number of insoluble foreign particles (10.00 μm≤, <100.00 μm) measured by MFI.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
3주 후after 3 weeks 25±2℃25±2℃
3주 후after 3 weeks 40±2℃40±2℃
3주 후after 3 weeks 5±3℃5±3℃
6주 후after 6 weeks 25±2℃25±2℃
6주 후after 6 weeks 40±2℃40±2℃
6주 후after 6 weeks 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 흔들림 shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 빛light
스트레스stress 실시예 7Example 7 33 1111 2121 33 2828 1111 9595 1313 3838 1010 3333 2121 88 실시예 8Example 8 1717 1616 5757 1515 2929 2020 6262 3939 1010 1717 33 2929 1515 실시예 9Example 9 33 55 88 1313 22 1313 6464 22 2525 88 1010 33 88 실시예 10Example 10 55 2020 1313 3939 2323 2020 3333 8484 3333 1818 00 1111 77 실시예 11Example 11 77 2929 1818 1313 1313 2323 3131 33 1818 2626 88 55 77 실시예 12Example 12 1010 33 77 44 22 1515 2626 1111 33 2020 1313 2020 2525 실시예 13Example 13 77 2626 1111 1515 2121 55 4848 2929 2323 3939 33 1111 2020 실시예 14Example 14 1010 3333 1111 1010 88 77 3434 55 1616 2525 22 223223 22 실시예 15Example 15 55 4646 4949 1515 33 2121 6161 77 1818 2020 33 2020 5757 실시예 16Example 16 2020 2929 1313 2828 4848 3838 9595 4949 4343 6767 1313 110110 3333 실시예 1Example 1 88 22 1010 1616 77 1010 2929 2020 1515 2121 33 7070 1818

표 40에서 실시예 7 내지 16의 불용성 이물 입자의 수(10.00㎛≤, <100.00㎛)는 모든 조건에서 300개 이하로 안정적이며, 실시예 1의 결과와 유사한 수준임을 알 수 있었다. In Table 40, it can be seen that the number of insoluble foreign particles of Examples 7 to 16 (10.00 μm≤, <100.00 μm) is stable to 300 or less under all conditions, and is at a level similar to the result of Example 1.

하기 표 41에서 MFI 로 측정한 불용성 이물 입자의 수(25.00㎛≤, <100.00㎛) 측정 결과를 나타내었다.Table 41 below shows the measurement results of the number of insoluble foreign particles (25.00 µm≤, <100.00 µm) measured by MFI.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
3주 후after 3 weeks 25±2℃25±2℃
3주 후after 3 weeks 40±2℃40±2℃
3주 후after 3 weeks 5±3℃5±3℃
6주 후after 6 weeks 25±2℃25±2℃
6주 후after 6 weeks 40±2℃40±2℃
6주 후after 6 weeks 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 흔들림 shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 빛light
스트레스stress 실시예 7Example 7 22 55 00 00 22 77 22 88 55 00 00 00 22 실시예 8Example 8 1212 77 33 55 33 22 55 00 00 22 22 22 00 실시예 9Example 9 00 00 22 00 22 22 77 00 00 22 22 00 22 실시예 10Example 10 00 22 22 33 55 22 33 00 22 33 00 33 00 실시예 11Example 11 22 00 88 33 22 55 33 22 00 22 33 00 00 실시예 12Example 12 22 00 22 22 00 55 00 00 22 22 00 00 00 실시예 13Example 13 22 33 00 00 22 00 00 22 22 33 22 33 00 실시예 14Example 14 33 55 22 00 22 00 77 00 22 55 00 88 00 실시예 15Example 15 22 55 77 77 22 33 77 22 33 00 00 55 00 실시예 16Example 16 33 77 22 22 1010 33 1313 22 77 1313 88 88 00 실시예 1Example 1 00 00 22 00 00 22 00 00 33 33 22 33 22

표 41에서 실시예 7 내지 16의 불용성 이물 입자의 수(25.00㎛≤, <100.00㎛)는 모든 조건에서 30개 이하로 안정적이며, 실시예 1의 결과와 유사한 수준임을 알 수 있었다. In Table 41, it can be seen that the number of insoluble foreign particles of Examples 7 to 16 (25.00 µm≤, <100.00 µm) is stable to 30 or less under all conditions, and is at a level similar to the result of Example 1.

하기 표 42에서 HIAC으로 측정한 불용성 이물 입자의 수(10.00≤(um)) 측정 결과를 나타내었다.Table 42 below shows the measurement results of the number of insoluble foreign particles (10.00≤(um)) measured by HIAC.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
3주 후after 3 weeks 25±2℃25±2℃
3주 후after 3 weeks 40±2℃40±2℃
3주 후after 3 weeks 5±3℃5±3℃
6주 후after 6 weeks 25±2℃25±2℃
6주 후after 6 weeks 40±2℃40±2℃
6주 후after 6 weeks 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 흔들림 shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 빛light
스트레스stress 실시예 7Example 7 8585 1010 1313 88 3232 1717 55 7272 1515 00 88 88 55 실시예 8Example 8 33 1818 88 00 1212 55 2727 55 55 88 1010 77 2020 실시예 9Example 9 22 55 55 33 1313 22 1717 55 33 33 1717 33 00 실시예 10Example 10 22 00 22 1010 77 88 55 2525 77 22 3535 22 00 실시예 11Example 11 1010 1717 00 88 00 55 2525 22 55 00 1818 22 00 실시예 12Example 12 22 33 77 55 22 33 1818 00 22 1515 2525 88 1313 실시예 13Example 13 22 22 55 77 55 55 2727 1313 88 1010 2020 88 00 실시예 14Example 14 55 22 33 33 33 22 1313 00 33 1515 1818 88 22 실시예 15Example 15 55 1313 88 1313 55 1212 4040 1010 55 2020 5353 1818 2020 실시예 16Example 16 2222 1313 1313 3535 2323 1717 3232 1515 2020 2525 1313 2020 2525 실시예 1Example 1 22 55 33 33 88 55 33 33 00 88 1010 22 2020

표 42에서 실시예 7 내지 16의 불용성 이물 입자의 수(10.00≤(um))는 모든 조건에서 100개 이하로 안정적이며, 실시예 1의 결과와 유사한 수준임을 알 수 있었다. In Table 42, it can be seen that the number of insoluble foreign particles (10.00≤(um)) of Examples 7 to 16 is stable to 100 or less under all conditions, and is at a level similar to the result of Example 1.

하기 표 43에서 HIAC으로 측정한 불용성 이물 입자의 수(25.00≤(um)) 측정 결과를 나타내었다.Table 43 below shows the measurement results of the number of insoluble foreign particles (25.00≤(um)) measured by HIAC.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
3주 후after 3 weeks 25±2℃25±2℃
3주 후after 3 weeks 40±2℃40±2℃
3주 후after 3 weeks 5±3℃5±3℃
6주 후after 6 weeks 25±2℃25±2℃
6주 후after 6 weeks 40±2℃40±2℃
6주 후after 6 weeks 5±3℃5±3℃
9주 후after 9 weeks 25±2℃25±2℃
9주 후after 9 weeks 40±2℃40±2℃
9주 후after 9 weeks 흔들림 shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 빛light
스트레스stress 실시예 7Example 7 4848 33 33 55 22 55 22 88 00 00 00 22 22 실시예 8Example 8 00 77 33 00 33 33 22 22 55 00 00 22 00 실시예 9Example 9 00 00 33 00 1313 00 22 22 22 00 22 22 00 실시예 10Example 10 22 00 00 33 55 00 00 22 00 00 22 00 00 실시예 11Example 11 1010 55 00 22 00 33 77 00 33 00 22 00 00 실시예 12Example 12 00 00 22 00 00 00 22 00 00 22 88 33 00 실시예 13Example 13 00 22 00 55 22 33 00 00 22 00 00 33 00 실시예 14Example 14 22 00 22 00 22 22 00 00 22 00 00 00 00 실시예 15Example 15 00 00 33 33 33 33 22 22 00 00 00 00 00 실시예 16Example 16 00 00 00 1010 00 00 22 00 00 00 00 33 00 실시예 1Example 1 22 00 22 00 33 00 22 22 00 00 00 00 33

표 43에서 실시예 7 내지 16의 불용성 이물 입자의 수(25.00≤(um))는 모든 조건에서 50개 이하로 안정적이며, 실시예 1의 결과와 유사한 수준임을 알 수 있었다. In Table 43, it can be seen that the number of insoluble foreign particles (25.00≤(um)) of Examples 7 to 16 is stable to 50 or less under all conditions, and is at a level similar to the result of Example 1.

실험예 4: 실시예 1의 장기간 안정성 평가Experimental Example 4: Long-term stability evaluation of Example 1

실시예 1의 장기간　안정성　평가를ICH(International Conference on Harmonisation )에서 제공한 가이드라인(Guideline Q5C Quality of Biotechnological Products: Stability Testing of Biotechnological 또는 Biological Products and ICH Guideline Q1A (R2): Stability Testing of New Drug Substances and Drug Products)에　따라　실시하였다．　Guideline Q5C Quality of Biotechnological Products: Stability Testing of Biotechnological or Biological Products and ICH Guideline Q1A (R2): Stability Testing of New Drug Substances and Drug Products).

상기 실험예 1의 방법으로 제조한 실시예 1의 안정한 액체 약제학적 제제 16 mL을 5±3℃/주변 상대 습도에서 밀폐 용기에 보관하였다. 상기 온도 및 습도에서 1개월, 2개월 및 3개월 후 안정성을 측정하였다.16 mL of the stable liquid pharmaceutical formulation of Example 1 prepared by the method of Experimental Example 1 was stored in an airtight container at 5±3° C./ambient relative humidity. Stability was measured after 1 month, 2 months and 3 months at the above temperature and humidity.

실시예 1의 장기간 안정성을 확인하기 위하여, 외관 분석, 항체 농도 측정, 환원 CE-SDS를 이용한 항체 경쇄화 중쇄 함량 및 비환원 CE-SDS를 이용한 온전한 면역 글로불린 G의 함량 측정, SEC-HPLC를 이용한 항체 주성분, 고분자량 성분 및 저분자량 성분 측정, IEC-HPLC를 이용한 전하 변형체 (메인 피크, 산성 피크 및 염기성 피크) 측정 그리고 SARS-CoV-2 RBD 결합 친화도 측정을 수행하였으며 그 결과를 표 44에서 50에 나타내었다.In order to confirm the long-term stability of Example 1, appearance analysis, antibody concentration measurement, antibody light chain heavy chain content using reduced CE-SDS and intact immunoglobulin G content using non-reduced CE-SDS measurement, SEC-HPLC Measurement of antibody main component, high molecular weight component and low molecular weight component, charge variant (main peak, acidic peak, and basic peak) measurement using IEC-HPLC, and SARS-CoV-2 RBD binding affinity measurement were performed. The results are shown in Table 44 50 is shown.

하기 표 44에서 외관 분석 결과를 나타내었다.The results of the appearance analysis are shown in Table 44 below.

구분division 5±3℃5±3℃
0개월 후after 0 months 5±3℃5±3℃
1개월 후1 month later 5±3℃5±3℃
2개월 후after 2 months 5±3℃5±3℃
3개월 후after 3 months 실시예 1Example 1 유백색milk white 유백색milk white 유백색milk white 유백색milk white

상기 표 44에서 나타난 바와 같이 실시예 1은 5±3℃에서 3 개월 후 외관상의 변화 없이 외관이 유지되었으므로 안정하다는 것을 알 수 있었다.As shown in Table 44, Example 1 was found to be stable because the appearance was maintained without any change in appearance after 3 months at 5 ± 3 ℃.

하기 표 45에서 항체 농도 (단위: mg/mL) 측정 결과를 나타내었다.Table 45 below shows the measurement results of antibody concentration (unit: mg/mL).

구분division 5±3℃5±3℃
0개월 후after 0 months 5±3℃5±3℃
1개월 후1 month later 5±3℃5±3℃
2개월 후after 2 months 5±3℃5±3℃
3개월 후after 3 months 실시예 1Example 1 61mg/mL61mg/mL 61mg/mL61mg/mL 60mg/mL60mg/mL 60mg/mL60mg/mL

상기 표 45에서 나타난 바와 같이 실시예 1은 5±3℃에서 3 개월 후 항체 농도의 변화 없이 일정하게 유지되었으므로 안정하다는 것을 알 수 있었다.As shown in Table 45, Example 1 was found to be stable because it was kept constant without a change in the antibody concentration after 3 months at 5 ± 3 ℃.

하기 표 46에서 항체 경쇄와 중쇄 함량 (환원 CE-SDS) 측정 결과를 나타내었다.Table 46 below shows the measurement results of the antibody light chain and heavy chain content (reduced CE-SDS).

구분division 5±3℃5±3℃
0개월 후after 0 months 5±3℃5±3℃
1개월 후1 month later 5±3℃5±3℃
2개월 후after 2 months 5±3℃5±3℃
3개월 후after 3 months 실시예 1Example 1 98.5198.51 98.8198.81 98.7498.74 98.6798.67

상기 표 46에서 나타난 바와 같이 실시예 1은 5±3℃에서 3 개월 후 항체 경쇄와 중쇄 함량의 변화 없이 일정하게 유지되었으므로 안정하다는 것을 알 수 있었다.As shown in Table 46, Example 1 was found to be stable because it was kept constant without change in the antibody light chain and heavy chain content after 3 months at 5 ± 3 ℃.

하기 표 47에서 온전한 면역 글로불린 G 함량(비환원 CE-SDS) 측정 결과를 나타내었다.Table 47 below shows the measurement results of intact immunoglobulin G content (non-reduced CE-SDS).

구분division 5±3℃5±3℃
0개월 후after 0 months 5±3℃5±3℃
1개월 후1 month later 5±3℃5±3℃
2개월 후after 2 months 5±3℃5±3℃
3개월 후after 3 months 실시예 1Example 1 89.2189.21 90.8090.80 90.0090.00 90.5890.58

(단위: %)(unit: %)

상기 표 47에서 나타난 바와 같이 실시예 1은 5±3℃에서 3 개월 후 온전한 면역 글로불린 G 함량의 변화 없이 일정하게 유지되었으므로 안정하다는 것을 알 수 있었다.As shown in Table 47, Example 1 was found to be stable since it was maintained at 5±3° C. for 3 months without change in the intact immunoglobulin G content.

하기 표 48에서 SEC-HPLC (주성분, 고분자량 성분, 저분자량 성분 함량) 측정 결과를 나타내었다.Table 48 below shows the measurement results of SEC-HPLC (main component, high molecular weight component, low molecular weight component content).

구분division 5±3℃5±3℃
0개월 후after 0 months 5±3℃5±3℃
1개월 후1 month later 5±3℃5±3℃
2개월 후after 2 months 5±3℃5±3℃
3개월 후after 3 months 실시예 1Example 1 주성분 함량main ingredient content 99.8299.82 99.7699.76 99.7799.77 99.7699.76 고분자량 성분high molecular weight ingredients 0.120.12 0.160.16 0.180.18 0.190.19 저분자량 성분low molecular weight ingredients 0.060.06 0.070.07 0.050.05 0.060.06

(단위: %)(unit: %)

상기 표 48에서 나타난 바와 같이 실시예 1은 5±3℃에서 3 개월 후 SEC-HPLC를 이용해 측정한 주성분, 고분자량 성분 및 저분자량 성분 함량의 변화 없이 일정하게 유지되었으므로 안정하다는 것을 알 수 있었다.As shown in Table 48, Example 1 was found to be stable because it was kept constant without changes in the main component, high molecular weight component, and low molecular weight component content measured by SEC-HPLC after 3 months at 5 ± 3 °C.

하기 표 49에서 IEC-HPLC (메인 피크, 산성 피크 및 염기성 피크) 측정 결과를 나타내었다.IEC-HPLC (main peak, acidic peak, and basic peak) measurement results are shown in Table 49 below.

구분division 5±3℃5±3℃
0개월 후after 0 months 5±3℃5±3℃
1개월 후1 month later 5±3℃5±3℃
2개월 후after 2 months 5±3℃5±3℃
3개월 후after 3 months 실시예 1Example 1 메인 피크main peak 63.9263.92 63.8863.88 64.2564.25 63.9163.91 산성 피크acid peak 7.457.45 7.697.69 7.537.53 6.466.46 염기성 피크basic peak 63.9263.92 63.8863.88 64.2564.25 63.9163.91

(단위: %)(unit: %)

상기 표 49에서 나타난 바와 같이 실시예 1은 5±3℃에서 3 개월 후 IEC-HPLC를 이용해 측정한 메인 피크, 산성 피크 및 염기성 피크 함량의 변화 없이 일정하게 유지되었으므로 안정하다는 것을 알 수 있었다.As shown in Table 49, Example 1 was found to be stable because it was kept constant without changes in the main peak, acidic peak, and basic peak contents measured using IEC-HPLC after 3 months at 5±3°C.

하기 표 50에서 SARS-CoV-2 RBD 결합 친화도 측정 결과를 나타내었다.Table 50 below shows the results of SARS-CoV-2 RBD binding affinity measurement.

구분division 5±3℃5±3℃
0개월 후after 0 months 5±3℃5±3℃
1개월 후1 month later 5±3℃5±3℃
2개월 후after 2 months 5±3℃5±3℃
3개월 후after 3 months 실시예 1Example 1 100100 9797 9494 9898

상기 표 50에서 나타난 바와 같이 실시예 1은 5±3℃에서 3 개월 후 SARS-CoV-2 RBD 결합 친화도가 변화 없이 일정하게 유지되었으므로 안정하다는 것을 알 수 있었다.As shown in Table 50, Example 1 was found to be stable because the SARS-CoV-2 RBD binding affinity was kept constant without change after 3 months at 5±3°C.

실험예 5: L-아르기닌-HCl/소르비톨/트레할로스 안정화제의 비교Experimental Example 5: Comparison of L-Arginine-HCl/Sorbitol/Trehalose Stabilizer

실험예 5에서 사용된 약제학적 제제와 관련하여, 각 완충액을 각 pH에 맞게 제조한 뒤 아르기닌 모노하이드로클로라이드, 소르비톨 및 트레할로스를 첨가하고, 이에 항체를 첨가하고, 계면활성제를 첨가하여 표 51의 시료들을 제조하였다. 제조된 약학적 제제를 5±3℃ 온도와 50±2℃ 온도에서 보관하였고, 5±3℃ 온도에서 5일 후의 안정성 그리고 50±2℃ 온도에서 3일 후 및 5일 후의 안정성을 측정하였다. 물리적 스트레스를 위해 -40℃에서 얼림과 녹임 5회를 반복하였고 상온에서 3000 rpm으로 4시간 동안 흔들림 스트레스를 가하였다. 실험의 결과는 표 52 내지 64 및 도 18 내지 22에 나타내었다.With respect to the pharmaceutical formulation used in Experimental Example 5, each buffer was prepared to suit each pH, and arginine monohydrochloride, sorbitol and trehalose were added thereto, an antibody was added thereto, and a surfactant was added to the sample of Table 51 were manufactured. The prepared pharmaceutical formulation was stored at a temperature of 5±3° C. and 50±2° C., and stability after 5 days at a temperature of 5±3° C. and stability after 3 days and 5 days at a temperature of 50±2° C. were measured. For physical stress, freezing and thawing were repeated 5 times at -40°C, and shaking stress was applied at room temperature at 3000 rpm for 4 hours. The results of the experiment are shown in Tables 52 to 64 and FIGS. 18 to 22 .

본 실험예 5에서 사용된 항체는 상기 표 3 내지 표 4에 기재된 No. 322번 결합 분자이다.Antibodies used in Experimental Example 5 were No. 1 described in Tables 3 to 4 above. It is the 322 bond molecule.

구분division 완충제buffer pHpH 안정화제stabilizer 계면활성제Surfactants 단백질(항체) 농도Protein (antibody) concentration 실시예 17Example 17 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌
모노하이드로클로라이드
150 mML-Arginine
monohydrochloride
150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 18Example 18 히스티딘 10 mMhistidine 10 mM 6.06.0 소르비톨5% (w/v)Sorbitol 5% (w/v) 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 19Example 19 히스티딘 10 mMhistidine 10 mM 6.06.0 트레할로스 10% (w/v)Trehalose 10% (w/v) 폴리소르베이트 800.05% (w/v)Polysorbate 800.05% (w/v) 60
mg/mL60
mg/mL

하기 표 52에서 탁도 측정 결과를 나타내었다.The turbidity measurement results are shown in Table 52 below.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 흔들림shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 실시예 17Example 17 0.00150.0015 0.00960.0096 0.01780.0178 0.01590.0159 0.00760.0076 0.01210.0121 실시예 18Example 18 0.00650.0065 0.01180.0118 0.00730.0073 0.00730.0073 0.01020.0102 0.00400.0040 실시예 19Example 19 0.00420.0042 0.00400.0040 0.00640.0064 0.00350.0035 0.00400.0040 0.00800.0080

표 52를 보면 모든 조건에서 실시예의 탁도가 0.0400 이하로 안정함을 알 수 있었다. Looking at Table 52, it can be seen that the turbidity of the Example is stable at 0.0400 or less under all conditions.

하기 표 53에서 항체 경쇄와 중쇄 함량 (환원 chip-based CE-SDS) 측정 결과를 나타내었다.Table 53 below shows the measurement results of the antibody light chain and heavy chain content (reduced chip-based CE-SDS).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 흔들림shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 실시예 17Example 17 99.8399.83 99.8599.85 99.7399.73 99.6199.61 99.8399.83 99.8399.83 실시예 18Example 18 99.8899.88 99.8499.84 99.7799.77 99.7299.72 99.8599.85 99.8599.85 실시예 19Example 19 99.8499.84 99.8599.85 99.7999.79 99.7399.73 99.8499.84 99.8399.83

(단위: %)(unit: %)

표 53을 보면 모든 조건에서 실시예 17 내지 19의 항체 경쇄와 중쇄 함량이 유사함을 알 수 있었다 (도 18).Looking at Table 53, it could be seen that the antibody light chain and heavy chain contents of Examples 17 to 19 were similar under all conditions (FIG. 18).

하기 표 54에서 온전한 면역 글로불린 G 함량 (비환원 chip-based CE-SDS) 측정 결과를 나타내었다.Table 54 below shows the measurement results of intact immunoglobulin G content (non-reducing chip-based CE-SDS).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 흔들림shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 실시예 17Example 17 99.2299.22 99.1799.17 99.1499.14 99.0699.06 99.1599.15 99.1399.13 실시예 18Example 18 99.1899.18 99.1899.18 99.1899.18 99.1299.12 99.1599.15 99.1799.17 실시예 19Example 19 99.1899.18 99.1799.17 99.1899.18 99.1399.13 99.1799.17 99.1299.12

(단위: %)표 54를 보면 실시예 17은 50±2℃ 조건에서 실시예 18 및 19에 비해 낮은 온전한 면역 글로불린G의 함량을 나타내었다 (도 19).(Unit: %) Referring to Table 54, Example 17 showed a lower content of intact immunoglobulin G compared to Examples 18 and 19 at 50±2° C. ( FIG. 19 ).

하기 표 55에서 전하 변이체 (메인 피크 %) 측정 결과를 나타내었다.Table 55 below shows the measurement results of charge variants (main peak %).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 흔들림shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 실시예 17Example 17 66.90 66.90 67.27 67.27 61.70 61.70 57.84 57.84 66.45 66.45 67.14 67.14 실시예 18Example 18 67.22 67.22 67.17 67.17 61.59 61.59 57.35 57.35 67.74 67.74 67.12 67.12 실시예 19Example 19 67.08 67.08 66.99 66.99 61.46 61.46 57.35 57.35 67.20 67.20 67.13 67.13

표 55를 보면 모든 조건에서 실시예 17 내지 19의 전하 변형체 (메인 피크 %) 함량이 유사한 수준임을 알 수 있었다. Referring to Table 55, it can be seen that the contents of the charge variants (main peak %) of Examples 17 to 19 were at a similar level under all conditions.

하기 표 56에서 전하 변이체 (산성 피크 %) 측정 결과를 나타내었다.Table 56 below shows the measurement results of charge variants (acid peak %).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 흔들림shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 실시예 17Example 17 14.90 14.90 14.70 14.70 19.13 19.13 22.74 22.74 14.97 14.97 14.76 14.76 실시예 18Example 18 14.93 14.93 14.89 14.89 20.89 20.89 25.32 25.32 14.75 14.75 14.81 14.81 실시예 19Example 19 15.04 15.04 14.93 14.93 20.81 20.81 25.52 25.52 15.08 15.08 15.07 15.07

표 56을 보면 모든 조건에서 실시예 17 내지 19의 전하 변형체 (산성 피크 %) 함량이 유사한 수준임을 알 수 있었다. Referring to Table 56, it can be seen that the contents of the charge variants (acid peak %) of Examples 17 to 19 were at a similar level under all conditions.

하기 표 57에서 전하 변이체 (염기성 피크 %) 측정 결과를 나타내었다.Table 57 below shows the measurement results of charge variants (basic peak %).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 흔들림shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 실시예 17Example 17 18.21 18.21 18.03 18.03 19.17 19.17 19.42 19.42 18.59 18.59 18.10 18.10 실시예 18Example 18 17.87 17.87 17.95 17.95 17.52 17.52 17.33 17.33 17.50 17.50 18.06 18.06 실시예 19Example 19 17.87 17.87 18.07 18.07 17.73 17.73 17.13 17.13 17.71 17.71 17.80 17.80

표 57을 보면 모든 조건에서 실시예 17 내지 19의 전하 변형체 (염기성 피크 %) 함량이 유사한 수준임을 알 수 있었다. Referring to Table 57, it can be seen that the contents of the charge variants (basic peak %) of Examples 17 to 19 were at a similar level under all conditions.

하기 표 58에서 주성분 함량 (Main peak %) 측정 결과를 나타내었다.Table 58 below shows the measurement results of the main component content (Main peak %).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 흔들림shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 실시예 17Example 17 99.59 99.59 99.58 99.58 98.61 98.61 98.02 98.02 99.5499.54 99.5599.55 실시예 18Example 18 99.50 99.50 99.52 99.52 99.02 99.02 98.72 98.72 99.5399.53 99.5699.56 실시예 19Example 19 99.54 99.54 99.51 99.51 99.03 99.03 98.74 98.74 99.5299.52 99.5499.54

표 58을 보면 50±2℃ 조건에서 실시예 17이 실시예 18 및 19에 비해 더 낮은 주성분 함량을 나타내었다. 얼림/녹임 스트레스 및 흔들림 스트레스에 의한 주성분 함량은 실시예 17 내지 19가 유사하며, 99.0% 이상으로 안정함을 알 수 있었다 (도 20).Referring to Table 58, Example 17 showed a lower main component content than Examples 18 and 19 under the conditions of 50 ± 2 °C. The main component content due to freezing/thawing stress and shaking stress was similar to Examples 17 to 19, and it was found that it was stable at 99.0% or more ( FIG. 20 ).

하기 표 59에서 고분자량 성분 함량 (pre-peak %) 측정 결과를 나타내었다.Table 59 below shows the measurement results of the high molecular weight component content (pre-peak %).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 흔들림shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 실시예 17Example 17 0.37 0.37 0.39 0.39 1.10 1.10 1.56 1.56 0.420.42 0.410.41 실시예 18Example 18 0.46 0.46 0.44 0.44 0.75 0.75 0.94 0.94 0.440.44 0.410.41 실시예 19Example 19 0.43 0.43 0.45 0.45 0.73 0.73 0.91 0.91 0.440.44 0.430.43

표 59를 보면 50±2℃ 조건에서 실시예 17의 고분자량 성분이 실시예 18 및 19에 비해 높았다 (도 21).Referring to Table 59, the high molecular weight component of Example 17 was higher than that of Examples 18 and 19 at 50±2° C. ( FIG. 21 ).

하기 표 60에서 저분자량 성분 함량 (post-peak %) 측정 결과를 나타내었다.Table 60 below shows the measurement results of the low molecular weight component content (post-peak %).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 흔들림shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 실시예 17Example 17 0.04 0.04 0.03 0.03 0.29 0.29 0.42 0.42 0.040.04 0.040.04 실시예 18Example 18 0.04 0.04 0.04 0.04 0.23 0.23 0.34 0.34 0.030.03 0.030.03 실시예 19Example 19 0.02 0.02 0.04 0.04 0.24 0.24 0.35 0.35 0.040.04 0.030.03

표 60을 보면 50±2℃ 조건에서 실시예 17의 저분자량 성분이 실시예 18 및 19에 비해 높았다 (도 22).Referring to Table 60, the low molecular weight component of Example 17 was higher than that of Examples 18 and 19 under the conditions of 50±2° C. ( FIG. 22 ).

하기 표 61에서 MFI 로 측정한 불용성 이물 입자의 수(10.00㎛≤, <100.00㎛) 측정 결과를 나타내었다.Table 61 below shows the measurement results of the number of insoluble foreign particles (10.00 μm≤, <100.00 μm) measured by MFI.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 흔들림shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 실시예 17Example 17 33 33 57 57 83 83 18 18 17 17 10 10 실시예 18Example 18 21 21 0 0 15 15 7 7 8 8 5 5 실시예 19Example 19 13 13 7 7 21 21 4 4 5 5 8 8

표 61을 보면 실시예 17 내지 19의 불용성 이물 입자의 수가 모든 조건에서 100개 이하로 안정함을 알 수 있었다. Looking at Table 61, it can be seen that the number of insoluble foreign particles of Examples 17 to 19 is stable at 100 or less under all conditions.

하기 표 62에서 MFI 로 측정한 불용성 이물 입자의 수(25.00㎛≤, <100.00㎛) 측정 결과를 나타내었다.Table 62 below shows the measurement results of the number of insoluble foreign particles (25.00 µm≤, <100.00 µm) measured by MFI.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 흔들림shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 실시예 17Example 17 12 12 7 7 14 14 5 5 2 2 5 5 실시예 18Example 18 5 5 0 0 4 4 2 2 0 0 0 0 실시예 19Example 19 7 7 0 0 5 5 0 0 0 0 0 0

표 62를 보면 실시예 17 내지 19의 불용성 이물 입자의 수가 모든 조건에서 20개 이하로 안정함을 알 수 있었다. Looking at Table 62, it can be seen that the number of insoluble foreign particles of Examples 17 to 19 is stable at 20 or less under all conditions.

하기 표 63에서 HIAC으로 측정한 불용성 이물 입자의 수(10.00≤(um)) 측정 결과를 나타내었다.Table 63 below shows the measurement results of the number of insoluble foreign particles (10.00≤(um)) measured by HIAC.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 흔들림shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 실시예 17Example 17 1717 3737 2727 22 77 00 실시예 18Example 18 88 55 00 22 77 00 실시예 19Example 19 00 00 33 00 55 88

표 63을 보면 실시예 17 내지 19의 불용성 이물 입자의 수가 모든 조건에서 100개 이하로 안정함을 알 수 있었다. Looking at Table 63, it can be seen that the number of insoluble foreign particles of Examples 17 to 19 is stable at 100 or less under all conditions.

하기 표 64에서 HIAC으로 측정한 불용성 이물 입자의 수(25.00≤(um)) 측정 결과를 나타내었다.Table 64 below shows the measurement results of the number of insoluble foreign particles (25.00≤(um)) measured by HIAC.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
5일 후5 days later 50±2℃50±2℃
3일 후3 days later 50±2℃50±2℃
5일 후5 days later 흔들림shake
스트레스stress 얼림/녹임freeze/thaw
스트레스stress 실시예 17Example 17 00 55 00 00 00 00 실시예 18Example 18 00 00 00 00 00 00 실시예 19Example 19 00 00 22 00 00 22

표 64를 보면 실시예 17 내지 19의 불용성 이물 입자의 수가 모든 조건에서 10개 이하로 안정함을 알 수 있었다. Looking at Table 64, it can be seen that the number of insoluble foreign particles of Examples 17 to 19 is stable to 10 or less under all conditions.

실험예 6: 완충액 종류에 따른 비교; 안정화제 종류에 따른 비교; 계면활성제 종류에 따른 비교; 히스티딘 농도에 따른 비교Experimental Example 6: Comparison according to buffer type; Comparison by type of stabilizer; Comparison according to type of surfactant; Comparison according to histidine concentration

실험예 6에서 사용된 약제학적 제제와 관련하여, 각 완충액 (아세테이트, 시트레이트, 숙시네이트, 포스페이트)을 각 pH에 맞게 제조한 뒤 아르기닌 모노하이드로클로라이드, 소듐클로라이드, 수크로오스 및 글리신을 첨가하고, 이에 항체를 첨가 후 농축하였다. 그 후 계면활성제 (폴리소르베이트 20 및 80, 폴록사머 188)를 첨가(단, 비교예 1은 미첨가)하여 표 65의 시료들을 제조하였다. 실시예 1은 실험예 1에 따라 최종적으로 선정된 제제이다. 제조된 약학적 제제를 5±3℃ 온도와 40±2℃ 온도 및 75±5% 상대 습도에서 보관하였고, 각 온도 조건에서 2주, 4주 후의 안정성을 측정하였다. 물리적 스트레스를 위해 상온 조건에서 3000 rpm으로 4시간의 흔들림 스트레스를 주었다. 결과는 표 66 내지 75 및 도 23 내지 25에 나타내었다.With respect to the pharmaceutical formulation used in Experimental Example 6, each buffer solution (acetate, citrate, succinate, phosphate) was prepared according to each pH, and arginine monohydrochloride, sodium chloride, sucrose and glycine were added thereto. After addition of the antibody, it was concentrated. Thereafter, surfactants (polysorbates 20 and 80, poloxamer 188) were added (however, Comparative Example 1 was not added) to prepare the samples in Table 65. Example 1 is a formulation finally selected according to Experimental Example 1. The prepared pharmaceutical formulation was stored at 5±3° C. temperature, 40±2° C. temperature, and 75±5% relative humidity, and stability after 2 weeks and 4 weeks at each temperature condition was measured. For physical stress, shaking stress was applied at 3000 rpm for 4 hours at room temperature. The results are shown in Tables 66 to 75 and FIGS. 23 to 25 .

본 실험예 6에서 사용된 항체는 상기 표 1 내지 표 2에 기재된 No. 139번 결합 분자이다. The antibody used in Experimental Example 6 was No. 1 described in Tables 1 to 2 above. 139 is the binding molecule.

구분division 완충제buffer pHpH 안정화제stabilizer 계면활성제Surfactants 단백질(항체)protein (antibody)
농도density 실시예 20Example 20 아세테이트 10 mMAcetate 10 mM 5.55.5 L-아르기닌
모노하이드로클로라이드 150 mML-Arginine
150 mM monohydrochloride 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 21Example 21 시트레이트 10 mMCitrate 10 mM 5.55.5 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 22Example 22 시트레이트 10 mMCitrate 10 mM 6.06.0 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 23Example 23 숙시네이트 10 mMSuccinate 10 mM 6.56.5 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 24Example 24 포스페이트 10 mMPhosphate 10 mM 6.06.0 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 25Example 25 포스페이트 10 mMPhosphate 10 mM 6.56.5 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 26Example 26 히스티딘 10 mMhistidine 10 mM 6.06.0 염화나트륨 150 mM150 mM sodium chloride 폴리소르베이트 80 0.05% (w/v)Polysorbate 80 0.05% (w/v) 60
mg/mL60
mg/mL 실시예 27Example 27 히스티딘 10 mMhistidine 10 mM 6.06.0 수크로오스 10 % (w/v)Sucrose 10% (w/v) 폴리소르베이트 80 0.05% (w/v)Polysorbate 80 0.05% (w/v) 60
mg/mL60
mg/mL 실시예 28Example 28 히스티딘 10 mMhistidine 10 mM 6.06.0 글리신 250 mMGlycine 250 mM 폴리소르베이트 80 0.05% (w/v)Polysorbate 80 0.05% (w/v) 60
mg/mL60
mg/mL 실시예 29Example 29 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 20
0.05% (w/v)Polysorbate 20
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 30Example 30 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴록사머 188
0.05% (w/v)Poloxamer 188
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 31Example 31 히스티딘 50 mMHistidine 50 mM 6.06.0 L-아르기닌모노하이드로클로라이드 150 mML-Arginine monohydrochloride 150 mM 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 실시예 1Example 1 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌
모노하이드로클로라이드 150 mML-Arginine
150 mM monohydrochloride 폴리소르베이트 80
0.05% (w/v)Polysorbate 80
0.05% (w/v) 60
mg/mL60
mg/mL 비교예 1Comparative Example 1 히스티딘 10 mMhistidine 10 mM 6.06.0 L-아르기닌
모노하이드로클로라이드 150 mML-Arginine
150 mM monohydrochloride -- 60
mg/mL60
mg/mL

하기 표 66에서 탁도 측정 결과를 나타내었다.The turbidity measurement results are shown in Table 66 below.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
2주 후After two weeks 40±2℃40±2℃
2주 후After two weeks 5±3℃5±3℃
4주 후after 4 weeks 40±2℃40±2℃
4주 후after 4 weeks 흔들림shake
스트레스stress 실시예 20 Example 20 0.00980.0098 0.01240.0124 0.00720.0072 0.00980.0098 0.01120.0112 0.00960.0096 실시예 21Example 21 0.01180.0118 0.00840.0084 0.00910.0091 0.00990.0099 0.01370.0137 0.01350.0135 실시예 22Example 22 0.01340.0134 0.00910.0091 0.01340.0134 0.01100.0110 0.00900.0090 0.01670.0167 실시예 23Example 23 0.01210.0121 0.00860.0086 0.00930.0093 0.00760.0076 0.00860.0086 0.04300.0430 실시예 24Example 24 0.01220.0122 0.00740.0074 0.00830.0083 0.00910.0091 0.00870.0087 0.01130.0113 실시예 25Example 25 0.00590.0059 0.00710.0071 0.00890.0089 0.00880.0088 0.01010.0101 0.01450.0145 실시예 26Example 26 0.01310.0131 0.01040.0104 0.01140.0114 0.00830.0083 0.01460.0146 0.02940.0294 실시예 27Example 27 0.00510.0051 0.00490.0049 0.00270.0027 0.00130.0013 0.00190.0019 0.00230.0023 실시예 28Example 28 0.00200.0020 0.00330.0033 0.00250.0025 0.00880.0088 0.00280.0028 0.00410.0041 실시예 29Example 29 0.00830.0083 0.00900.0090 0.00890.0089 0.00990.0099 0.00850.0085 0.01050.0105 실시예 30Example 30 0.00910.0091 0.00770.0077 0.00900.0090 0.01080.0108 0.00720.0072 0.01320.0132 실시예 31Example 31 0.00800.0080 0.00780.0078 0.00880.0088 0.00930.0093 0.00970.0097 0.01280.0128 실시예 1Example 1 0.00830.0083 0.00690.0069 0.01070.0107 0.00760.0076 0.00680.0068 0.01250.0125 비교예 1Comparative Example 1 0.00960.0096 0.00800.0080 0.00910.0091 0.01090.0109 0.00830.0083 0.33790.3379

표 66을 보면, 실시예 20 내지 31의 탁도는 모든 온도 보관 조건에서 0.0400이하로 안정적이며, 실시예 1과 차이가 없는 것을 알 수 있었다. 하지만 흔들림 스트레스에서 비교예 1의 탁도가 매우 크게 증가하는 것으로 보아 물리적인 흔들림 스트레스에 계면활성제의 존재가 필수적임을 알 수 있었다. Looking at Table 66, it can be seen that the turbidity of Examples 20 to 31 is stable at 0.0400 or less under all temperature storage conditions, and there is no difference from Example 1. However, it can be seen that the presence of a surfactant is essential for the physical shaking stress, as the turbidity of Comparative Example 1 is significantly increased in the shaking stress.

하기 표 67에서 온전한 면역 글로불린 G 함량(비환원 CE-SDS) 측정 결과를 나타내었다.Table 67 below shows the measurement results of intact immunoglobulin G content (non-reduced CE-SDS).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
2주 후After two weeks 40±2℃40±2℃
2주 후After two weeks 5±3℃5±3℃
4주 후after 4 weeks 40±2℃40±2℃
4주 후after 4 weeks 흔들림shake
스트레스stress 실시예 20 Example 20 98.66 98.66 98.2398.23 97.6197.61 97.9297.92 97.2297.22 98.59 98.59 실시예 21Example 21 98.65 98.65 98.2498.24 97.6297.62 98.0098.00 97.2697.26 98.59 98.59 실시예 22Example 22 98.61 98.61 98.2698.26 97.4997.49 97.9297.92 97.7397.73 98.63 98.63 실시예 23Example 23 98.49 98.49 98.2298.22 97.7397.73 98.0398.03 97.6997.69 98.60 98.60 실시예 24Example 24 98.64 98.64 98.2098.20 97.7097.70 97.9297.92 97.5397.53 98.55 98.55 실시예 25Example 25 98.64 98.64 98.2298.22 97.6297.62 97.9797.97 96.9996.99 98.50 98.50 실시예 26Example 26 98.61 98.61 98.2198.21 97.6997.69 98.0498.04 96.9296.92 98.58 98.58 실시예 27Example 27 98.61 98.61 98.2298.22 97.5997.59 98.0098.00 97.2897.28 98.44 98.44 실시예 28Example 28 98.64 98.64 98.1498.14 97.8897.88 98.0098.00 96.9996.99 98.54 98.54 실시예 29Example 29 98.62 98.62 98.1098.10 97.7897.78 97.9397.93 97.3997.39 98.56 98.56 실시예 30Example 30 98.57 98.57 98.1798.17 97.8797.87 98.0298.02 97.0997.09 98.57 98.57 실시예 31Example 31 98.75 98.75 97.9897.98 97.9197.91 98.0298.02 97.8097.80 98.56 98.56 실시예 1Example 1 98.59 98.59 98.1398.13 97.8797.87 97.7797.77 97.5097.50 98.50 98.50 비교예 1Comparative Example 1 98.65 98.65 98.0698.06 97.6197.61 97.9297.92 97.5297.52 98.54 98.54

(단위: %)(unit: %)

상기 표 67에서 나타난 바와 같이 실시예 20 내지 31은 5±3℃와 40±2℃ 온도 및 75±5% 상대 습도 조건에서 4주 후 온전한 면역 글로불린 G 함량이 실시예 1과 차이가 없었다. 또한 흔들림 스트레스에 의한 영향 감소 현상 없이 안정함을 알 수 있었다 (도 23).As shown in Table 67, Examples 20 to 31 did not differ from Example 1 in the intact immunoglobulin G content after 4 weeks at 5±3° C. and 40±2° C. and 75±5% relative humidity conditions. In addition, it was confirmed that there was no decrease in the effect of shaking stress (FIG. 23).

하기 표 68에서 항체 경쇄와 중쇄 함량 (환원 CE-SDS) 측정 결과를 나타내었다.Table 68 below shows the measurement results of the antibody light chain and heavy chain content (reduced CE-SDS).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃5±3℃
2주 후After two weeks 40±2℃40±2℃
2주 후After two weeks 5±3℃5±3℃
4주 후after 4 weeks 40±2℃40±2℃
4주 후after 4 weeks 흔들림shake
스트레스stress 실시예 20 Example 20 99.6099.60 99.5599.55 99.3199.31 99.5999.59 99.1899.18 99.5799.57 실시예 21Example 21 99.6099.60 99.5599.55 99.3199.31 99.5999.59 99.2499.24 99.5599.55 실시예 22Example 22 99.6199.61 99.5499.54 99.3299.32 99.6199.61 99.2999.29 99.6099.60 실시예 23Example 23 99.6199.61 99.5599.55 99.3999.39 99.5999.59 99.2999.29 99.5699.56 실시예 24Example 24 99.5999.59 99.5699.56 99.3999.39 99.5999.59 99.2699.26 99.5899.58 실시예 25Example 25 99.5799.57 99.5399.53 99.1599.15 99.5799.57 98.8798.87 99.5999.59 실시예 26Example 26 99.6399.63 99.5599.55 99.4299.42 99.6099.60 99.3599.35 99.5699.56 실시예 27Example 27 99.6199.61 99.5499.54 99.3999.39 99.5799.57 99.3499.34 99.5899.58 실시예 28Example 28 99.6299.62 99.5499.54 99.2899.28 99.5999.59 99.2199.21 99.6099.60 실시예 29Example 29 99.6099.60 99.5499.54 99.3999.39 99.5799.57 99.2899.28 99.5599.55 실시예 30Example 30 99.6099.60 99.5599.55 99.3799.37 99.5999.59 99.2899.28 99.5699.56 실시예 31Example 31 99.5999.59 99.5599.55 99.3699.36 99.5899.58 99.4099.40 99.5399.53 실시예 1Example 1 99.5199.51 99.5399.53 99.3099.30 99.5699.56 99.2699.26 99.5799.57 비교예 1Comparative Example 1 99.5799.57 99.5499.54 99.3999.39 99.5799.57 99.2899.28 99.5999.59

(단위: %)(unit: %)

상기 표 68에서 나타난 바와 같이 실시예 20 내지 31은 5±3°C와 40±2℃ 온도 및 75±5% 상대 습도 조건에서 4주 후 항체의 경쇄와 중쇄 함량의 변화 없이 일정하게 유지되었으므로 안정하다는 것을 알 수 있었다. 또한 흔들림 스트레스에 대해서도 안정함을 확인하였다 (도 24).As shown in Table 68, Examples 20 to 31 were stable because they were kept constant without change in the light chain and heavy chain contents of the antibody after 4 weeks at 5±3 ° C, 40 ± 2 ° C temperature, and 75 ± 5% relative humidity conditions. knew that it was In addition, it was confirmed that it is stable against shaking stress (FIG. 24).

하기 표 69에서 SEC-HPLC 주성분 함량 (Main peak %) 측정 결과를 나타내었다.SEC-HPLC main component content (Main peak %) measurement results are shown in Table 69 below.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃
2주 후
　 5±3℃
After two weeks
40±2℃
2주 후
　 40±2℃
After two weeks
5±3℃
4주 후
　 5±3℃
after 4 weeks
40±2℃
4주 후
　 40±2℃
after 4 weeks
흔들림
스트레스
　 shake
stress
실시예 20 Example 20 99.6499.64 99.5899.58 98.7998.79 99.5799.57 98.3798.37 99.6199.61 실시예 21Example 21 99.6599.65 99.5799.57 98.7998.79 99.5699.56 98.4098.40 99.6199.61 실시예 22Example 22 99.6399.63 99.5599.55 98.9798.97 99.5499.54 98.6798.67 99.6299.62 실시예 23Example 23 99.6399.63 99.5599.55 98.9698.96 99.5399.53 98.6898.68 99.5899.58 실시예 24Example 24 99.6099.60 99.5199.51 98.9798.97 99.4999.49 98.6398.63 99.5899.58 실시예 25Example 25 99.5699.56 99.4399.43 98.8498.84 99.4299.42 98.4998.49 99.5499.54 실시예 26Example 26 99.5599.55 99.4599.45 98.7398.73 99.4299.42 98.3998.39 99.5399.53 실시예 27Example 27 99.5999.59 99.5399.53 99.0499.04 99.5399.53 98.5898.58 99.5699.56 실시예 28Example 28 99.5999.59 99.5399.53 99.1399.13 99.4999.49 98.8798.87 99.6199.61 실시예 29Example 29 99.5899.58 99.5399.53 99.0199.01 99.5099.50 98.6798.67 99.5999.59 실시예 30Example 30 99.5799.57 99.5499.54 99.0299.02 99.5299.52 98.7198.71 99.6399.63 실시예 31Example 31 99.6599.65 99.5299.52 99.0899.08 99.5399.53 98.7898.78 99.6599.65 실시예 1Example 1 99.5999.59 99.5499.54 98.9998.99 99.5099.50 98.5998.59 99.6199.61 비교예 1Comparative Example 1 99.6199.61 99.5699.56 99.0199.01 99.5399.53 98.7198.71 99.6099.60

표 69를 보면 실시예 20 내지 31은 5±3°C 조건에서 4주 후 주성분 함량이 99.0% 이상으로 안정함을 확인하였다. 40±2℃ 온도 및 75±5% 상대 습도 조건에서 주성분 함량의 감소를 보이지만 4주 후 주성분 함량은 모든 실시예에서 98.0% 이상으로 안정함을 확인하였고, 실시예 1과 큰 차이가 없음을 알 수 있었다 (도 25).Referring to Table 69, it was confirmed that Examples 20 to 31 were stable with a main component content of 99.0% or more after 4 weeks at 5±3°C conditions. Although a decrease in the main component content was seen at 40 ± 2 ° C. temperature and 75 ± 5% relative humidity conditions, it was confirmed that the main component content was stable at 98.0% or more in all examples after 4 weeks, and there was no significant difference from Example 1. could (Fig. 25).

하기 표 70에서 고분자량 성분 함량 (pre-peak %) 측정 결과를 나타내었다.Table 70 below shows the measurement results of the high molecular weight component content (pre-peak %).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃
2주 후
　 5±3℃
After two weeks
40±2℃
2주 후
　 40±2℃
After two weeks
5±3℃
4주 후
　 5±3℃
after 4 weeks
40±2℃
4주 후
　 40±2℃
after 4 weeks
흔들림
스트레스
　 shake
stress
실시예 20 Example 20 0.290.29 0.360.36 0.600.60 0.350.35 0.660.66 0.310.31 실시예 21Example 21 0.290.29 0.370.37 0.640.64 0.360.36 0.670.67 0.310.31 실시예 22Example 22 0.310.31 0.390.39 0.670.67 0.380.38 0.750.75 0.320.32 실시예 23Example 23 0.310.31 0.390.39 0.710.71 0.390.39 0.780.78 0.360.36 실시예 24Example 24 0.340.34 0.430.43 0.710.71 0.440.44 0.820.82 0.360.36 실시예 25Example 25 0.390.39 0.500.50 0.860.86 0.510.51 0.960.96 0.420.42 실시예 26Example 26 0.390.39 0.490.49 0.910.91 0.500.50 1.001.00 0.400.40 실시예 27Example 27 0.360.36 0.400.40 0.670.67 0.400.40 0.940.94 0.370.37 실시예 28Example 28 0.340.34 0.420.42 0.610.61 0.430.43 0.660.66 0.340.34 실시예 29Example 29 0.360.36 0.400.40 0.660.66 0.420.42 0.760.76 0.350.35 실시예 30Example 30 0.350.35 0.390.39 0.650.65 0.400.40 0.710.71 0.330.33 실시예 31Example 31 0.310.31 0.430.43 0.610.61 0.400.40 0.660.66 0.320.32 실시예 1Example 1 0.350.35 0.400.40 0.660.66 0.420.42 0.800.80 0.340.34 비교예 1Comparative Example 1 0.330.33 0.380.38 0.660.66 0.400.40 0.720.72 0.340.34

표 70을 보면 실시예 20 내지 31은 모든 온도조건에서 4주 후 그리고 흔들림 스트레스 후 고분자량 성분이 1.0% 이하로 안정함을 알 수 있었다. 또한 실시예 1의 결과와 큰 차이가 없음을 알 수 있었다. Referring to Table 70, it was found that Examples 20 to 31 were stable at 1.0% or less of high molecular weight components after 4 weeks and after shaking stress under all temperature conditions. In addition, it was found that there was no significant difference from the results of Example 1.

하기 표 71에서 저분자량 성분 함량 (post-peak %) 측정 결과를 나타내었다.Table 71 below shows the measurement results of the low molecular weight component content (post-peak %).

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃
2주 후
　 5±3℃
After two weeks
40±2℃
2주 후
　 40±2℃
After two weeks
5±3℃
4주 후
　 5±3℃
after 4 weeks
40±2℃
4주 후
　 40±2℃
after 4 weeks
흔들림
스트레스
　 shake
stress
실시예 20 Example 20 0.070.07 0.060.06 0.610.61 0.080.08 0.980.98 0.080.08 실시예 21Example 21 0.060.06 0.060.06 0.580.58 0.080.08 0.930.93 0.080.08 실시예 22Example 22 0.070.07 0.060.06 0.350.35 0.080.08 0.580.58 0.060.06 실시예 23Example 23 0.060.06 0.060.06 0.340.34 0.080.08 0.540.54 0.060.06 실시예 24Example 24 0.060.06 0.060.06 0.320.32 0.070.07 0.560.56 0.060.06 실시예 25Example 25 0.050.05 0.060.06 0.310.31 0.080.08 0.550.55 0.040.04 실시예 26Example 26 0.070.07 0.060.06 0.360.36 0.080.08 0.610.61 0.070.07 실시예 27Example 27 0.050.05 0.060.06 0.290.29 0.070.07 0.480.48 0.070.07 실시예 28Example 28 0.080.08 0.060.06 0.260.26 0.070.07 0.470.47 0.040.04 실시예 29Example 29 0.070.07 0.060.06 0.340.34 0.080.08 0.580.58 0.060.06 실시예 30Example 30 0.080.08 0.060.06 0.330.33 0.080.08 0.580.58 0.040.04 실시예 31Example 31 0.040.04 0.060.06 0.320.32 0.070.07 0.560.56 0.040.04 실시예 1Example 1 0.070.07 0.060.06 0.350.35 0.080.08 0.610.61 0.050.05 비교예 1Comparative Example 1 0.060.06 0.060.06 0.330.33 0.070.07 0.570.57 0.060.06

표 71을 보면 실시예 20 내지 31은 모든 온도조건에서 4주 후 그리고 흔들림 스트레스 후 저분자량 성분이 1.0% 이하로 안정함을 알 수 있었다. 또한 실시예 1의 결과와 큰 차이가 없음을 알 수 있었다.Referring to Table 71, it can be seen that Examples 20 to 31 were stable at 1.0% or less of low molecular weight components after 4 weeks and after shaking stress in all temperature conditions. In addition, it was found that there was no significant difference from the results of Example 1.

하기 표 72에서 MFI 로 측정한 불용성 이물 입자의 수(10.00㎛≤, <100.00㎛) 측정 결과를 나타내었다.Table 72 below shows the measurement results of the number of insoluble foreign particles (10.00 μm≤, <100.00 μm) measured by MFI.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃
2주 후
　 5±3℃
After two weeks
40±2℃
2주 후
　 40±2℃
After two weeks
5±3℃
4주 후
　 5±3℃
after 4 weeks
40±2℃
4주 후
　 40±2℃
after 4 weeks
흔들림
스트레스
　 shake
stress
실시예 20 Example 20 44 1010 3030 1010 2525 152152 실시예 21Example 21 44 2626 22 2424 1313 13911391 실시예 22Example 22 44 2222 4141 1313 2525 592592 실시예 23Example 23 1111 22 2020 2222 1010 10501050 실시예 24Example 24 1515 44 2323 00 3333 327327 실시예 25Example 25 3737 44 1717 2626 77 4848 실시예 26Example 26 22 00 1313 33 4242 32413241 실시예 27Example 27 77 44 88 2626 1111 1616 실시예 28Example 28 44 55 88 77 1919 9797 실시예 29Example 29 1515 33 165165 1313 3737 2424 실시예 30Example 30 1111 1818 1212 2727 8686 398398 실시예 31Example 31 66 22 1111 77 2424 228228 실시예 1Example 1 66 44 22 44 2424 145145 비교예 1Comparative Example 1 3333 7474 6666 298298 497497 255093255093

표 72를 보면 비교예 1에서 계면활성제가 없을 경우 불용성 이물 입자의 수가 매우 크게 증가함을 확인하였다. 온도 보관뿐만 아니라 흔들림 스트레스에서 불용성 이물 입자의 생성을 막기 위해 계면활성제가 필요하다는 것을 확인할 수 있었다. 실시예 26의 경우 흔들림 스트레스에 의한 불용성 이물 입자의 수가 다른 실시예에 비해 상대적으로 높았다. Referring to Table 72, it was confirmed that in Comparative Example 1, in the absence of a surfactant, the number of insoluble foreign particles was significantly increased. It was confirmed that a surfactant was needed to prevent the generation of insoluble foreign particles under shaking stress as well as temperature storage. In the case of Example 26, the number of insoluble foreign particles due to shaking stress was relatively higher than in the other examples.

하기 표 73에서 MFI 로 측정한 불용성 이물 입자의 수(25.00㎛≤, <100.00㎛) 측정 결과를 나타내었다.Table 73 below shows the measurement results of the number of insoluble foreign particles (25.00 μm≤, <100.00 μm) measured by MFI.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃
2주 후
　 5±3℃
After two weeks
40±2℃
2주 후
　 40±2℃
After two weeks
5±3℃
4주 후
　 5±3℃
after 4 weeks
40±2℃
4주 후
　 40±2℃
after 4 weeks
흔들림
스트레스
　 shake
stress
실시예 20 Example 20 22 22 44 22 44 2525 실시예 21Example 21 00 00 00 22 22 1515 실시예 22Example 22 22 22 66 00 00 2828 실시예 23Example 23 00 00 22 44 00 99 실시예 24Example 24 00 00 22 00 44 100100 실시예 25Example 25 00 22 00 55 22 00 실시예 26Example 26 22 00 00 00 22 7878 실시예 27Example 27 00 00 00 44 00 22 실시예 28Example 28 00 33 22 00 44 2121 실시예 29Example 29 00 00 44 44 44 22 실시예 30Example 30 00 22 00 44 2020 99 실시예 31Example 31 00 00 00 22 00 6868 실시예 1Example 1 00 00 00 00 00 1212 비교예 1Comparative Example 1 00 00 77 1515 4545 14511451

표 73을 보면 계면활성제가 없는 비교예 1을 제외하고 나머지 실시예 20 내지 31의 불용성 이물 입자의 수에 비추어 모든 온도조건에서 4주 후 안정함을 알 수 있었다. Looking at Table 73, it can be seen that, in view of the number of insoluble foreign particles of Examples 20 to 31, except for Comparative Example 1 without a surfactant, it is stable after 4 weeks in all temperature conditions.

하기 표 74에서 HIAC으로 측정한 불용성 이물 입자의 수(10.00≤(um)) 측정 결과를 나타내었다.In Table 74, the number of insoluble foreign particles (10.00≤(um)) measured by HIAC is shown.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃
2주 후
　 5±3℃
After two weeks
40±2℃
2주 후
　 40±2℃
After two weeks
5±3℃
4주 후
　 5±3℃
after 4 weeks
40±2℃
4주 후
　 40±2℃
after 4 weeks
흔들림
스트레스
　 shake
stress
실시예 20 Example 20 33 00 2323 6565 22 22 실시예 21Example 21 33 22 22 22 55 00 실시예 22Example 22 22 00 55 22 33 22 실시예 23Example 23 00 00 2828 22 00 22 실시예 24Example 24 00 00 00 22 00 5050 실시예 25Example 25 7575 22 1212 88 22 00 실시예 26Example 26 00 88 1212 22 33 1818 실시예 27Example 27 77 1515 1010 2020 1818 1515 실시예 28Example 28 1818 22 77 2323 55 5555 실시예 29Example 29 00 00 22 00 55 77 실시예 30Example 30 33 33 33 22 1717 365365 실시예 31Example 31 00 22 1212 22 00 153153 실시예 1Example 1 22 00 55 00 88 9595 비교예 1Comparative Example 1 55 00 00 1313 22 2460324603

표 74를 보면 비교예 1을 제외한 실시예 20 내지 31의 불용성 이물 입자의 수가 모든 온도 보관 조건에서 100개 이하로 안정함을 알 수 있었다. Referring to Table 74, it can be seen that the number of insoluble foreign particles of Examples 20 to 31 except for Comparative Example 1 is 100 or less under all temperature storage conditions.

하기 표 75에서 HIAC으로 측정한 불용성 이물 입자의 수(25.00≤(um)) 측정 결과를 나타내었다.Table 75 below shows the measurement results of the number of insoluble foreign particles (25.00≤(um)) measured by HIAC.

구분division 5±3℃5±3℃
0일 후after 0 days
(T=0)(T=0) 5±3℃
2주 후
　 5±3℃
After two weeks
40±2℃
2주 후
　 40±2℃
After two weeks
5±3℃
4주 후
　 5±3℃
after 4 weeks
40±2℃
4주 후
　 40±2℃
after 4 weeks
흔들림
스트레스
　 shake
stress
실시예 20 Example 20 22 00 33 55 00 22 실시예 21Example 21 00 00 00 00 00 00 실시예 22Example 22 22 00 00 00 00 00 실시예 23Example 23 00 00 1010 00 00 00 실시예 24Example 24 00 00 00 00 00 3232 실시예 25Example 25 4343 00 55 00 00 00 실시예 26Example 26 00 00 1010 00 00 00 실시예 27Example 27 00 22 00 22 00 00 실시예 28Example 28 22 00 22 77 00 88 실시예 29Example 29 00 00 00 00 00 00 실시예 30Example 30 00 22 00 00 33 33 실시예 31Example 31 00 00 88 00 00 1818 실시예 1Example 1 00 00 22 00 00 4040 비교예 1Comparative Example 1 33 00 00 00 00 1619516195

표 75를 보면 비교예 1을 제외한 실시예 20 내지 31의 불용성 이물 입자의 수에 비추어 모든 온도 조건에서 안정함을 알 수 있었고, 실시예 1의 결과와 유사한 것을 알 수 있었다.Looking at Table 75, it can be seen that in light of the number of insoluble foreign particles of Examples 20 to 31 except for Comparative Example 1, it is stable in all temperature conditions, and it can be seen that the results are similar to those of Example 1.

<110> CELLTRION, INC. <120> STABLE PHARMACEUTICAL FORMULATION <130> CPD2021059KR <150> KR 10-2020-0100805 <151> 2020-08-11 <160> 3842 <170> KoPatentIn 3.0 <210> 1 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 1 LC CDR1 <400> 1 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 1 LC CDR2 <400> 2 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 3 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 1 LC CDR3 <400> 3 Gln Gln Ser Tyr Ser Thr Pro Phe Thr 1 5 <210> 4 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 1 HC CDR1 <400> 4 Asp Tyr Ala Met His 1 5 <210> 5 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 1 HC CDR2 <400> 5 Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 6 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 1 HC CDR3 <400> 6 Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu Asp Ala 1 5 10 15 Phe Asp Ile <210> 7 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 2 LC CDR1 <400> 7 Arg Ala Ser Gln Ser Ile Ser Thr Tyr Leu Asn 1 5 10 <210> 8 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 2 LC CDR2 <400> 8 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 9 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 2 LC CDR3 <400> 9 Gln Gln Ser Tyr Ser Ile Pro His Thr 1 5 <210> 10 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 2 HC CDR1 <400> 10 Asp Tyr Ala Met His 1 5 <210> 11 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 2 HC CDR2 <400> 11 Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 12 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 2 HC CDR3 <400> 12 Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu Asp Ala 1 5 10 15 Phe Asp Ile <210> 13 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 3 LC CDR1 <400> 13 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 14 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 3 LC CDR2 <400> 14 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 15 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 3 LC CDR3 <400> 15 Gln Gln Tyr Asp Asn Leu Pro Ile Thr 1 5 <210> 16 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 3 HC CDR1 <400> 16 Ser Tyr Ala Met Ser 1 5 <210> 17 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 3 HC CDR2 <400> 17 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 18 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 3 HC CDR3 <400> 18 Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr Ser Trp 1 5 10 15 Phe Asp Pro <210> 19 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 4 LC CDR1 <400> 19 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 20 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 4 LC CDR2 <400> 20 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 21 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 4 LC CDR3 <400> 21 Gln Gln Tyr Asp Asp Leu Pro Ile Thr 1 5 <210> 22 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 4 HC CDR1 <400> 22 Ser Tyr Ala Met Ser 1 5 <210> 23 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 4 HC CDR2 <400> 23 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 24 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 4 HC CDR3 <400> 24 Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr Ser Trp 1 5 10 15 Phe Asp Pro <210> 25 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 5 LC CDR1 <400> 25 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 26 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 5 LC CDR2 <400> 26 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 27 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 5 LC CDR3 <400> 27 Gln Gln Tyr Asp Asn Leu Pro Ile Thr 1 5 <210> 28 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 5 HC CDR1 <400> 28 Ser Tyr Ala Met Ser 1 5 <210> 29 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 5 HC CDR2 <400> 29 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 30 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 5 HC CDR3 <400> 30 Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr Ser Trp 1 5 10 15 Phe Asp Pro <210> 31 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 6 LC CDR1 <400> 31 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 32 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 6 LC CDR2 <400> 32 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 33 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 6 LC CDR3 <400> 33 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 34 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 6 HC CDR1 <400> 34 Ser Tyr Ala Ile Ser 1 5 <210> 35 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 6 HC CDR2 <400> 35 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 36 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 6 HC CDR3 <400> 36 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 37 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 7 LC CDR1 <400> 37 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 38 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 7 LC CDR2 <400> 38 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 39 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 7 LC CDR3 <400> 39 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 40 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 7 HC CDR1 <400> 40 Ser Tyr Ala Ile Ser 1 5 <210> 41 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 7 HC CDR2 <400> 41 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 42 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 7 HC CDR3 <400> 42 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 43 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC CDR1 <400> 43 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 44 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC CDR2 <400> 44 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 45 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC CDR3 <400> 45 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 46 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC CDR1 <400> 46 Ser Tyr Ala Ile Ser 1 5 <210> 47 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC CDR2 <400> 47 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 48 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC CDR3 <400> 48 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 49 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.9 LC CDR1 <400> 49 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 50 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.9 LC CDR2 <400> 50 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 51 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.9 LC CDR3 <400> 51 Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 1 5 10 <210> 52 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.9 HC CDR1 <400> 52 Ser Tyr Ala Ile Ser 1 5 <210> 53 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.9 HC CDR2 <400> 53 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 54 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.9 HC CDR3 <400> 54 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 55 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC CDR1 <400> 55 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 56 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC CDR2 <400> 56 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 57 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC CDR3 <400> 57 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 58 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC CDR1 <400> 58 Ser Tyr Ala Ile Ser 1 5 <210> 59 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC CDR2 <400> 59 Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 60 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC CDR3 <400> 60 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 61 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.11 LC CDR1 <400> 61 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 62 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.11 LC CDR2 <400> 62 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 63 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.11 LC CDR3 <400> 63 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 64 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.11 HC CDR1 <400> 64 Ser Tyr Ala Ile Ser 1 5 <210> 65 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.11 HC CDR2 <400> 65 Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 66 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.11 HC CDR3 <400> 66 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 67 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.12 LC CDR1 <400> 67 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 68 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.12 LC CDR2 <400> 68 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 69 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.12 LC CDR3 <400> 69 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 70 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.12 HC CDR1 <400> 70 Ser Tyr Ala Ile Ser 1 5 <210> 71 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.12 HC CDR2 <400> 71 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 72 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.12 HC CDR3 <400> 72 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 73 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.13 LC CDR1 <400> 73 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Tyr 1 5 10 <210> 74 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.13 LC CDR2 <400> 74 Gly Asn Tyr Gln Arg Pro Ser 1 5 <210> 75 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.13 LC CDR3 <400> 75 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 76 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.13 HC CDR1 <400> 76 Ser Tyr Ala Ile Ser 1 5 <210> 77 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.13 HC CDR2 <400> 77 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 78 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.13 HC CDR3 <400> 78 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 79 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.14 LC CDR1 <400> 79 Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn Tyr Val His 1 5 10 <210> 80 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.14 LC CDR2 <400> 80 Ser Asn Asp Gln Arg Pro Ser 1 5 <210> 81 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.14 LC CDR3 <400> 81 Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 1 5 10 <210> 82 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.14 HC CDR1 <400> 82 Ser Tyr Ala Ile Ser 1 5 <210> 83 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.14 HC CDR2 <400> 83 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 84 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.14 HC CDR3 <400> 84 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 85 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.15 LC CDR1 <400> 85 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 86 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.15 LC CDR2 <400> 86 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 87 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.15 LC CDR3 <400> 87 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 88 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.15 HC CDR1 <400> 88 Ser Tyr Ala Ile Ser 1 5 <210> 89 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.15 HC CDR2 <400> 89 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 90 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.15 HC CDR3 <400> 90 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 91 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC CDR1 <400> 91 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 92 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC CDR2 <400> 92 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 93 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC CDR3 <400> 93 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 94 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC CDR1 <400> 94 Ser Tyr Ala Ile Ser 1 5 <210> 95 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC CDR2 <400> 95 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 96 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC CDR3 <400> 96 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 97 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC CDR1 <400> 97 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 98 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC CDR2 <400> 98 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 99 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC CDR3 <400> 99 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 100 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC CDR1 <400> 100 Ser Tyr Ala Ile Ser 1 5 <210> 101 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC CDR2 <400> 101 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 102 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC CDR3 <400> 102 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 103 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.18 LC CDR1 <400> 103 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 104 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.18 LC CDR2 <400> 104 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 105 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.18 LC CDR3 <400> 105 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Lys Val 1 5 10 <210> 106 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.18 HC CDR1 <400> 106 Ser Tyr Ala Ile Ser 1 5 <210> 107 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.18 HC CDR2 <400> 107 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 108 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.18 HC CDR3 <400> 108 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 109 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC CDR1 <400> 109 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 110 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC CDR2 <400> 110 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 111 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC CDR3 <400> 111 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 112 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.19 HC CDR1 <400> 112 Ser Tyr Ala Ile Ser 1 5 <210> 113 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.19 HC CDR2 <400> 113 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 114 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.19 HC CDR3 <400> 114 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 115 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.20 LC CDR1 <400> 115 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 116 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.20 LC CDR2 <400> 116 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 117 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.20 LC CDR3 <400> 117 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 118 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.20 HC CDR1 <400> 118 Ser Tyr Ala Ile Ser 1 5 <210> 119 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.20 HC CDR2 <400> 119 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 120 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.20 HC CDR3 <400> 120 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 121 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC CDR1 <400> 121 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 122 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC CDR2 <400> 122 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 123 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC CDR3 <400> 123 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 124 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC CDR1 <400> 124 Ser Tyr Ala Ile Ser 1 5 <210> 125 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC CDR2 <400> 125 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 126 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC CDR3 <400> 126 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 127 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.22 LC CDR1 <400> 127 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 128 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.22 LC CDR2 <400> 128 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 129 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.22 LC CDR3 <400> 129 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 130 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.22 HC CDR1 <400> 130 Ser Tyr Ala Ile Ser 1 5 <210> 131 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.22 HC CDR2 <400> 131 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 132 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.22 HC CDR3 <400> 132 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 133 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC CDR1 <400> 133 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 134 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC CDR2 <400> 134 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 135 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC CDR3 <400> 135 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 136 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.23 HC CDR1 <400> 136 Ser Tyr Ala Ile Ser 1 5 <210> 137 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.23 HC CDR2 <400> 137 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 138 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.23 HC CDR3 <400> 138 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 139 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.24 LC CDR1 <400> 139 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 140 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.24 LC CDR2 <400> 140 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 141 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.24 LC CDR3 <400> 141 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 142 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.24 HC CDR1 <400> 142 Ser Tyr Ala Ile Ser 1 5 <210> 143 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.24 HC CDR2 <400> 143 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 144 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.24 HC CDR3 <400> 144 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 145 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC CDR1 <400> 145 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 146 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC CDR2 <400> 146 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 147 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC CDR3 <400> 147 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 148 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC CDR1 <400> 148 Ser Tyr Ala Ile Ser 1 5 <210> 149 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC CDR2 <400> 149 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 150 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC CDR3 <400> 150 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 151 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC CDR1 <400> 151 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 152 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC CDR2 <400> 152 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 153 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC CDR3 <400> 153 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 154 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC CDR1 <400> 154 Ser Tyr Ala Ile Ser 1 5 <210> 155 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC CDR2 <400> 155 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 156 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC CDR3 <400> 156 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 157 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC CDR1 <400> 157 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 158 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC CDR2 <400> 158 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 159 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC CDR3 <400> 159 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 160 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC CDR1 <400> 160 Ser Tyr Ala Ile Ser 1 5 <210> 161 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC CDR2 <400> 161 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 162 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC CDR3 <400> 162 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 163 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC CDR1 <400> 163 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 164 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC CDR2 <400> 164 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 165 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC CDR3 <400> 165 Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 1 5 10 <210> 166 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC CDR1 <400> 166 Ser Tyr Ala Ile Ser 1 5 <210> 167 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC CDR2 <400> 167 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 168 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC CDR3 <400> 168 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 169 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC CDR1 <400> 169 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 170 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC CDR2 <400> 170 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 171 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC CDR3 <400> 171 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 172 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC CDR1 <400> 172 Ser Tyr Ala Ile Ser 1 5 <210> 173 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC CDR2 <400> 173 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 174 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC CDR3 <400> 174 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 175 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.30 LC CDR1 <400> 175 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 176 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.30 LC CDR2 <400> 176 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 177 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.30 LC CDR3 <400> 177 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 178 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.30 HC CDR1 <400> 178 Ser Tyr Ala Ile Ser 1 5 <210> 179 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.30 HC CDR2 <400> 179 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 180 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.30 HC CDR3 <400> 180 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 181 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.31 LC CDR1 <400> 181 Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn Tyr Val His 1 5 10 <210> 182 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.31 LC CDR2 <400> 182 Ser Asn Asp Gln Arg Pro Ser 1 5 <210> 183 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.31 LC CDR3 <400> 183 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 184 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.31 HC CDR1 <400> 184 Ser Tyr Ala Ile Ser 1 5 <210> 185 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.31 HC CDR2 <400> 185 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 186 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.31 HC CDR3 <400> 186 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 187 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC CDR1 <400> 187 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 188 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC CDR2 <400> 188 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 189 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC CDR3 <400> 189 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 190 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC CDR1 <400> 190 Ser Tyr Ala Ile Ser 1 5 <210> 191 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC CDR2 <400> 191 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 192 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC CDR3 <400> 192 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 193 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC CDR1 <400> 193 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 194 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC CDR2 <400> 194 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 195 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC CDR3 <400> 195 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 196 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC CDR1 <400> 196 Ser Tyr Ala Ile Ser 1 5 <210> 197 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC CDR2 <400> 197 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 198 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC CDR3 <400> 198 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 199 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC CDR1 <400> 199 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 200 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC CDR2 <400> 200 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 201 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC CDR3 <400> 201 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 202 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC CDR1 <400> 202 Ser Tyr Ala Ile Ser 1 5 <210> 203 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC CDR2 <400> 203 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 204 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC CDR3 <400> 204 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 205 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC CDR1 <400> 205 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 206 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC CDR2 <400> 206 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 207 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC CDR3 <400> 207 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 208 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC CDR1 <400> 208 Ser Tyr Ala Ile Ser 1 5 <210> 209 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC CDR2 <400> 209 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 210 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC CDR3 <400> 210 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 211 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC CDR1 <400> 211 Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 212 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC CDR2 <400> 212 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 213 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC CDR3 <400> 213 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 214 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC CDR1 <400> 214 Ser Tyr Ala Ile Ser 1 5 <210> 215 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC CDR2 <400> 215 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 216 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC CDR3 <400> 216 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 217 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC CDR1 <400> 217 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 218 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC CDR2 <400> 218 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 219 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC CDR3 <400> 219 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 220 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC CDR1 <400> 220 Ser Tyr Ala Ile Ser 1 5 <210> 221 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC CDR2 <400> 221 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 222 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC CDR3 <400> 222 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 223 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC CDR1 <400> 223 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 224 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC CDR2 <400> 224 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 225 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC CDR3 <400> 225 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 226 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.38 HC CDR1 <400> 226 Ser Tyr Ala Ile Ser 1 5 <210> 227 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.38 HC CDR2 <400> 227 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 228 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.38 HC CDR3 <400> 228 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 229 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC CDR1 <400> 229 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 230 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC CDR2 <400> 230 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 231 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC CDR3 <400> 231 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 232 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC CDR1 <400> 232 Ser Tyr Ala Ile Ser 1 5 <210> 233 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC CDR2 <400> 233 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 234 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC CDR3 <400> 234 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 235 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.40 LC CDR1 <400> 235 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 236 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.40 LC CDR2 <400> 236 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 237 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.40 LC CDR3 <400> 237 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 238 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.40 HC CDR1 <400> 238 Ser Tyr Ala Ile Ser 1 5 <210> 239 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.40 HC CDR2 <400> 239 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 240 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.40 HC CDR3 <400> 240 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 241 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC CDR1 <400> 241 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 242 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC CDR2 <400> 242 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 243 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC CDR3 <400> 243 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 244 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC CDR1 <400> 244 Ser Tyr Ala Ile Ser 1 5 <210> 245 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC CDR2 <400> 245 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 246 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC CDR3 <400> 246 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 247 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC CDR1 <400> 247 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 248 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC CDR2 <400> 248 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 249 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC CDR3 <400> 249 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 250 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC CDR1 <400> 250 Ser Tyr Ala Ile Ser 1 5 <210> 251 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC CDR2 <400> 251 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 252 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC CDR3 <400> 252 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 253 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC CDR1 <400> 253 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 254 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC CDR2 <400> 254 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 255 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC CDR3 <400> 255 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 256 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC CDR1 <400> 256 Ser Tyr Ala Ile Ser 1 5 <210> 257 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC CDR2 <400> 257 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 258 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC CDR3 <400> 258 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 259 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC CDR1 <400> 259 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 260 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC CDR2 <400> 260 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 261 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC CDR3 <400> 261 Gln Gln Tyr Val Thr Thr Pro Tyr Thr 1 5 <210> 262 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC CDR1 <400> 262 Arg Ser Ser Tyr Tyr Trp Gly 1 5 <210> 263 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC CDR2 <400> 263 Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 264 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC CDR3 <400> 264 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 265 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC CDR1 <400> 265 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 266 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC CDR2 <400> 266 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 267 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC CDR3 <400> 267 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 268 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC CDR1 <400> 268 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 269 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC CDR2 <400> 269 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 270 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC CDR3 <400> 270 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 271 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC CDR1 <400> 271 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 272 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC CDR2 <400> 272 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 273 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC CDR3 <400> 273 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 274 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC CDR1 <400> 274 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 275 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC CDR2 <400> 275 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 276 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC CDR3 <400> 276 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 277 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC CDR1 <400> 277 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 278 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC CDR2 <400> 278 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 279 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC CDR3 <400> 279 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 280 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC CDR1 <400> 280 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 281 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC CDR2 <400> 281 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 282 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC CDR3 <400> 282 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 283 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC CDR1 <400> 283 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 284 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC CDR2 <400> 284 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 285 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC CDR3 <400> 285 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 286 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC CDR1 <400> 286 His Tyr Phe Trp Ser 1 5 <210> 287 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC CDR2 <400> 287 Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 288 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC CDR3 <400> 288 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 289 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.49 LC CDR1 <400> 289 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 290 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.49 LC CDR2 <400> 290 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 291 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.49 LC CDR3 <400> 291 Ser Ser Tyr Thr Ser Ser Ser Thr Val Val 1 5 10 <210> 292 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.49 HC CDR1 <400> 292 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 293 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.49 HC CDR2 <400> 293 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 294 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.49 HC CDR3 <400> 294 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 295 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC CDR1 <400> 295 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 296 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC CDR2 <400> 296 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 297 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC CDR3 <400> 297 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 298 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC CDR1 <400> 298 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 299 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC CDR2 <400> 299 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 300 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC CDR3 <400> 300 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 301 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC CDR1 <400> 301 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 302 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC CDR2 <400> 302 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 303 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC CDR3 <400> 303 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 304 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC CDR1 <400> 304 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 305 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC CDR2 <400> 305 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 306 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC CDR3 <400> 306 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 307 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.52 LC CDR1 <400> 307 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 308 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.52 LC CDR2 <400> 308 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 309 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.52 LC CDR3 <400> 309 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 310 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.52 HC CDR1 <400> 310 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 311 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.52 HC CDR2 <400> 311 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 312 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.52 HC CDR3 <400> 312 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 313 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC CDR1 <400> 313 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 314 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC CDR2 <400> 314 Gly Gly Ser Ser Arg Ala Thr 1 5 <210> 315 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC CDR3 <400> 315 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 316 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC CDR1 <400> 316 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 317 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC CDR2 <400> 317 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 318 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC CDR3 <400> 318 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 319 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC CDR1 <400> 319 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 320 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC CDR2 <400> 320 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 321 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC CDR3 <400> 321 Ser Ser Tyr Thr Ser Ser Ser Thr His Val 1 5 10 <210> 322 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC CDR1 <400> 322 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 323 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC CDR2 <400> 323 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 324 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC CDR3 <400> 324 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 325 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC CDR1 <400> 325 Arg Ala Ser Gln Ser Val Ser Thr Tyr Leu Ala 1 5 10 <210> 326 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC CDR2 <400> 326 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 327 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC CDR3 <400> 327 Gln Gln Tyr Gly Ser Ser Pro Ser Ile Thr 1 5 10 <210> 328 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC CDR1 <400> 328 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 329 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC CDR2 <400> 329 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 330 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC CDR3 <400> 330 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 331 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC CDR1 <400> 331 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 332 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC CDR2 <400> 332 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 333 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC CDR3 <400> 333 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 334 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC CDR1 <400> 334 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 335 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC CDR2 <400> 335 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 336 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC CDR3 <400> 336 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 337 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.57 LC CDR1 <400> 337 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 338 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.57 LC CDR2 <400> 338 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 339 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.57 LC CDR3 <400> 339 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 340 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.57 HC CDR1 <400> 340 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 341 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.57 HC CDR2 <400> 341 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 342 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.57 HC CDR3 <400> 342 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 343 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.58 LC CDR1 <400> 343 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 344 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.58 LC CDR2 <400> 344 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 345 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.58 LC CDR3 <400> 345 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 346 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.58 HC CDR1 <400> 346 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 347 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.58 HC CDR2 <400> 347 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 348 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.58 HC CDR3 <400> 348 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 349 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC CDR1 <400> 349 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 350 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC CDR2 <400> 350 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 351 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC CDR3 <400> 351 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 352 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC CDR1 <400> 352 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 353 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC CDR2 <400> 353 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 354 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC CDR3 <400> 354 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 355 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC CDR1 <400> 355 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 356 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC CDR2 <400> 356 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 357 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC CDR3 <400> 357 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 358 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.60 HC CDR1 <400> 358 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 359 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.60 HC CDR2 <400> 359 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 360 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.60 HC CDR3 <400> 360 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 361 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC CDR1 <400> 361 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 362 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC CDR2 <400> 362 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 363 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC CDR3 <400> 363 Gln Gln Tyr Tyr Ser Thr Pro Ser Ile Thr 1 5 10 <210> 364 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC CDR1 <400> 364 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 365 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC CDR2 <400> 365 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 366 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC CDR3 <400> 366 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 367 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC CDR1 <400> 367 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 368 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC CDR2 <400> 368 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 369 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC CDR3 <400> 369 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 370 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC CDR1 <400> 370 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 371 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC CDR2 <400> 371 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 372 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC CDR3 <400> 372 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 373 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC CDR1 <400> 373 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 374 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC CDR2 <400> 374 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 375 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC CDR3 <400> 375 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 376 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC CDR1 <400> 376 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 377 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC CDR2 <400> 377 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 378 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC CDR3 <400> 378 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 379 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC CDR1 <400> 379 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 380 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC CDR2 <400> 380 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 381 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC CDR3 <400> 381 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 382 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC CDR1 <400> 382 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 383 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC CDR2 <400> 383 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 384 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC CDR3 <400> 384 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 385 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC CDR1 <400> 385 Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala 1 5 10 <210> 386 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC CDR2 <400> 386 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 387 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC CDR3 <400> 387 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 388 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC CDR1 <400> 388 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 389 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC CDR2 <400> 389 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 390 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC CDR3 <400> 390 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 391 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC CDR1 <400> 391 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 392 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC CDR2 <400> 392 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 393 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC CDR3 <400> 393 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 394 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC CDR1 <400> 394 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 395 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC CDR2 <400> 395 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 396 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC CDR3 <400> 396 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 397 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC CDR1 <400> 397 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 398 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC CDR2 <400> 398 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 399 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC CDR3 <400> 399 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 400 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC CDR1 <400> 400 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 401 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC CDR2 <400> 401 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 402 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC CDR3 <400> 402 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 403 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC CDR1 <400> 403 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 404 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC CDR2 <400> 404 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 405 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC CDR3 <400> 405 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 406 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC CDR1 <400> 406 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 407 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC CDR2 <400> 407 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 408 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC CDR3 <400> 408 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 409 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC CDR1 <400> 409 Arg Ala Ser Gln Ser Val Arg Ser Ser Tyr Leu Ala 1 5 10 <210> 410 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC CDR2 <400> 410 Ala Ala Ser Thr Arg Ala Thr 1 5 <210> 411 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC CDR3 <400> 411 Gln Gln Tyr Gly Asp Ser Leu Ser Ile Thr 1 5 10 <210> 412 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC CDR1 <400> 412 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 413 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC CDR2 <400> 413 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 414 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC CDR3 <400> 414 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 415 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.70 LC CDR1 <400> 415 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 416 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.70 LC CDR2 <400> 416 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 417 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.70 LC CDR3 <400> 417 Gln Gln Tyr Gly Ser Ser Pro Ser Ile Thr 1 5 10 <210> 418 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.70 HC CDR1 <400> 418 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 419 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.70 HC CDR2 <400> 419 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 420 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.70 HC CDR3 <400> 420 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 421 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC CDR1 <400> 421 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 422 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC CDR2 <400> 422 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 423 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC CDR3 <400> 423 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 424 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC CDR1 <400> 424 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 425 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC CDR2 <400> 425 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 426 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC CDR3 <400> 426 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 427 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC CDR1 <400> 427 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Ser 1 5 10 <210> 428 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC CDR2 <400> 428 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 429 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC CDR3 <400> 429 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Pro 1 5 10 <210> 430 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC CDR1 <400> 430 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 431 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC CDR2 <400> 431 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 432 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC CDR3 <400> 432 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 433 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC CDR1 <400> 433 Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala 1 5 10 <210> 434 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC CDR2 <400> 434 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 435 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC CDR3 <400> 435 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 436 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC CDR1 <400> 436 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 437 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC CDR2 <400> 437 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 438 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC CDR3 <400> 438 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 439 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC CDR1 <400> 439 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 440 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC CDR2 <400> 440 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 441 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC CDR3 <400> 441 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 442 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC CDR1 <400> 442 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 443 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC CDR2 <400> 443 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 444 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC CDR3 <400> 444 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 445 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC CDR1 <400> 445 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 446 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC CDR2 <400> 446 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 447 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC CDR3 <400> 447 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 448 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC CDR1 <400> 448 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 449 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC CDR2 <400> 449 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 450 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC CDR3 <400> 450 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 451 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC CDR1 <400> 451 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 452 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC CDR2 <400> 452 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 453 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC CDR3 <400> 453 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 454 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC CDR1 <400> 454 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 455 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC CDR2 <400> 455 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 456 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC CDR3 <400> 456 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 457 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC CDR1 <400> 457 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 458 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC CDR2 <400> 458 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 459 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC CDR3 <400> 459 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 460 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC CDR1 <400> 460 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 461 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC CDR2 <400> 461 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 462 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC CDR3 <400> 462 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 463 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC CDR1 <400> 463 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 464 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC CDR2 <400> 464 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 465 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC CDR3 <400> 465 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 466 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC CDR1 <400> 466 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 467 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC CDR2 <400> 467 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 468 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC CDR3 <400> 468 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 469 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC CDR1 <400> 469 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 470 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC CDR2 <400> 470 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 471 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC CDR3 <400> 471 Gln Gln Tyr Tyr Ser Thr Pro Ser Ile Thr 1 5 10 <210> 472 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC CDR1 <400> 472 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 473 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC CDR2 <400> 473 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 474 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC CDR3 <400> 474 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 475 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC CDR1 <400> 475 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 476 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC CDR2 <400> 476 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 477 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC CDR3 <400> 477 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 478 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC CDR1 <400> 478 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 479 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC CDR2 <400> 479 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 480 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC CDR3 <400> 480 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 481 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC CDR1 <400> 481 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 482 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC CDR2 <400> 482 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 483 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC CDR3 <400> 483 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 484 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC CDR1 <400> 484 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 485 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC CDR2 <400> 485 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 486 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC CDR3 <400> 486 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 487 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC CDR1 <400> 487 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 488 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC CDR2 <400> 488 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 489 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC CDR3 <400> 489 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 490 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC CDR1 <400> 490 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 491 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC CDR2 <400> 491 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 492 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC CDR3 <400> 492 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 493 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC CDR1 <400> 493 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 494 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC CDR2 <400> 494 Gly Ala Ser Thr Arg Ala Thr 1 5 <210> 495 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC CDR3 <400> 495 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 496 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC CDR1 <400> 496 Gly Ser Ser Tyr Tyr Trp Gly 1 5 <210> 497 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC CDR2 <400> 497 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 498 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC CDR3 <400> 498 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 499 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC CDR1 <400> 499 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 500 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC CDR2 <400> 500 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 501 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC CDR3 <400> 501 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 502 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC CDR1 <400> 502 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 503 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC CDR2 <400> 503 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 504 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC CDR3 <400> 504 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 505 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC CDR1 <400> 505 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 506 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC CDR2 <400> 506 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 507 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC CDR3 <400> 507 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 508 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC CDR1 <400> 508 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 509 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC CDR2 <400> 509 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 510 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC CDR3 <400> 510 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 511 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC CDR1 <400> 511 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 512 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC CDR2 <400> 512 Asp Ala Ser Ser Arg Ala Thr 1 5 <210> 513 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC CDR3 <400> 513 Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 1 5 <210> 514 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC CDR1 <400> 514 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 515 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC CDR2 <400> 515 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 516 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC CDR3 <400> 516 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 517 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC CDR1 <400> 517 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 518 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC CDR2 <400> 518 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 519 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC CDR3 <400> 519 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 520 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC CDR1 <400> 520 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 521 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC CDR2 <400> 521 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 522 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC CDR3 <400> 522 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 523 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC CDR1 <400> 523 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 524 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC CDR2 <400> 524 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 525 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC CDR3 <400> 525 Gln Gln Tyr Gly Ser Ser Pro Ser Ile Thr 1 5 10 <210> 526 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC CDR1 <400> 526 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 527 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC CDR2 <400> 527 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 528 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC CDR3 <400> 528 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 529 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC CDR1 <400> 529 Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn Tyr Val Ser 1 5 10 <210> 530 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC CDR2 <400> 530 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 531 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC CDR3 <400> 531 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 532 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC CDR1 <400> 532 Thr Ser Gly Met Gly Val Gly 1 5 <210> 533 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC CDR2 <400> 533 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 534 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC CDR3 <400> 534 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 535 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC CDR1 <400> 535 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 536 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC CDR2 <400> 536 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 537 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC CDR3 <400> 537 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 538 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC CDR1 <400> 538 Thr Ser Gly Met Gly Val Gly 1 5 <210> 539 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC CDR2 <400> 539 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 540 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC CDR3 <400> 540 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 541 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC CDR1 <400> 541 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 542 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC CDR2 <400> 542 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 543 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC CDR3 <400> 543 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 544 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC CDR1 <400> 544 Thr Ser Gly Val Gly Val Gly 1 5 <210> 545 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC CDR2 <400> 545 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 546 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC CDR3 <400> 546 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 547 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC CDR1 <400> 547 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 548 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC CDR2 <400> 548 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 549 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC CDR3 <400> 549 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 550 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC CDR1 <400> 550 Thr Ser Gly Met Gly Val Gly 1 5 <210> 551 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC CDR2 <400> 551 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 552 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC CDR3 <400> 552 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 553 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC CDR1 <400> 553 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 554 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC CDR2 <400> 554 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 555 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC CDR3 <400> 555 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Arg 1 5 10 <210> 556 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC CDR1 <400> 556 Thr Ser Gly Val Gly Val Gly 1 5 <210> 557 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC CDR2 <400> 557 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 558 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC CDR3 <400> 558 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 559 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC CDR1 <400> 559 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 560 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC CDR2 <400> 560 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 561 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC CDR3 <400> 561 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 562 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC CDR1 <400> 562 Thr Ser Gly Met Gly Val Gly 1 5 <210> 563 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC CDR2 <400> 563 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 564 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC CDR3 <400> 564 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 565 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC CDR1 <400> 565 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 566 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC CDR2 <400> 566 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 567 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC CDR3 <400> 567 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 568 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC CDR1 <400> 568 Thr Ser Gly Val Gly Val Gly 1 5 <210> 569 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC CDR2 <400> 569 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 570 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC CDR3 <400> 570 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 571 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.96 LC CDR1 <400> 571 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 572 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.96 LC CDR2 <400> 572 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 573 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.96 LC CDR3 <400> 573 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 574 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.96 HC CDR1 <400> 574 Thr Ser Gly Met Gly Val Gly 1 5 <210> 575 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.96 HC CDR2 <400> 575 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 576 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.96 HC CDR3 <400> 576 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 577 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC CDR1 <400> 577 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 578 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC CDR2 <400> 578 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 579 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC CDR3 <400> 579 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 580 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC CDR1 <400> 580 Thr Ser Gly Met Gly Val Ser 1 5 <210> 581 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC CDR2 <400> 581 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 582 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC CDR3 <400> 582 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 583 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.98 LC CDR1 <400> 583 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 584 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.98 LC CDR2 <400> 584 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 585 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.98 LC CDR3 <400> 585 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 586 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.98 HC CDR1 <400> 586 Thr Ser Gly Met Gly Val Gly 1 5 <210> 587 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.98 HC CDR2 <400> 587 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 588 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.98 HC CDR3 <400> 588 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 589 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC CDR1 <400> 589 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 590 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC CDR2 <400> 590 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 591 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC CDR3 <400> 591 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 592 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC CDR1 <400> 592 Thr Ser Gly Met Gly Val Gly 1 5 <210> 593 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC CDR2 <400> 593 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 594 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC CDR3 <400> 594 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 595 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC CDR1 <400> 595 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 596 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC CDR2 <400> 596 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 597 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC CDR3 <400> 597 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 598 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.100 HC CDR1 <400> 598 Thr Ser Gly Met Gly Val Gly 1 5 <210> 599 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.100 HC CDR2 <400> 599 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 600 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.100 HC CDR3 <400> 600 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 601 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.101 LC CDR1 <400> 601 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 602 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.101 LC CDR2 <400> 602 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 603 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.101 LC CDR3 <400> 603 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 604 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.101 HC CDR1 <400> 604 Thr Ser Gly Met Gly Val Gly 1 5 <210> 605 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.101 HC CDR2 <400> 605 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 606 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.101 HC CDR3 <400> 606 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 607 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC CDR1 <400> 607 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 608 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC CDR2 <400> 608 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 609 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC CDR3 <400> 609 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 610 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC CDR1 <400> 610 Thr Ser Gly Met Gly Val Gly 1 5 <210> 611 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC CDR2 <400> 611 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 612 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC CDR3 <400> 612 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 613 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC CDR1 <400> 613 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 614 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC CDR2 <400> 614 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 615 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC CDR3 <400> 615 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 616 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC CDR1 <400> 616 Thr Ser Gly Val Gly Val Gly 1 5 <210> 617 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC CDR2 <400> 617 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 618 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC CDR3 <400> 618 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 619 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC CDR1 <400> 619 Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 620 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC CDR2 <400> 620 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 621 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC CDR3 <400> 621 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 622 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC CDR1 <400> 622 Thr Ser Gly Val Gly Val Gly 1 5 <210> 623 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC CDR2 <400> 623 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 624 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC CDR3 <400> 624 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 625 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC CDR1 <400> 625 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 626 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC CDR2 <400> 626 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 627 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC CDR3 <400> 627 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 628 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC CDR1 <400> 628 Thr Ser Gly Val Gly Val Gly 1 5 <210> 629 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC CDR2 <400> 629 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 630 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC CDR3 <400> 630 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 631 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC CDR1 <400> 631 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 632 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC CDR2 <400> 632 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 633 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC CDR3 <400> 633 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 634 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC CDR1 <400> 634 Thr Ser Gly Met Gly Val Gly 1 5 <210> 635 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC CDR2 <400> 635 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 636 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC CDR3 <400> 636 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 637 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC CDR1 <400> 637 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 638 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC CDR2 <400> 638 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 639 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC CDR3 <400> 639 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 640 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC CDR1 <400> 640 Thr Ser Gly Met Gly Val Gly 1 5 <210> 641 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC CDR2 <400> 641 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 642 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC CDR3 <400> 642 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 643 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC CDR1 <400> 643 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 644 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC CDR2 <400> 644 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 645 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC CDR3 <400> 645 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 646 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC CDR1 <400> 646 Thr Ser Gly Met Gly Val Gly 1 5 <210> 647 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC CDR2 <400> 647 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 648 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC CDR3 <400> 648 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 649 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC CDR1 <400> 649 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 650 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC CDR2 <400> 650 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 651 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC CDR3 <400> 651 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 652 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC CDR1 <400> 652 Thr Ser Gly Met Gly Val Gly 1 5 <210> 653 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC CDR2 <400> 653 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 654 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC CDR3 <400> 654 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 655 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC CDR1 <400> 655 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 656 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC CDR2 <400> 656 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 657 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC CDR3 <400> 657 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 658 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.110 HC CDR1 <400> 658 Thr Ser Gly Met Gly Val Gly 1 5 <210> 659 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.110 HC CDR2 <400> 659 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 660 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.110 HC CDR3 <400> 660 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 661 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC CDR1 <400> 661 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 662 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC CDR2 <400> 662 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 663 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC CDR3 <400> 663 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 664 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC CDR1 <400> 664 Thr Ser Gly Met Gly Val Gly 1 5 <210> 665 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC CDR2 <400> 665 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 666 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC CDR3 <400> 666 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 667 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC CDR1 <400> 667 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 668 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC CDR2 <400> 668 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 669 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC CDR3 <400> 669 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 670 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC CDR1 <400> 670 Thr Ser Gly Val Gly Val Gly 1 5 <210> 671 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC CDR2 <400> 671 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 672 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC CDR3 <400> 672 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 673 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC CDR1 <400> 673 Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn Tyr Ile Ser 1 5 10 <210> 674 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC CDR2 <400> 674 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 675 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC CDR3 <400> 675 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 676 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC CDR1 <400> 676 Thr Ser Gly Val Gly Val Gly 1 5 <210> 677 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC CDR2 <400> 677 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 678 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC CDR3 <400> 678 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 679 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC CDR1 <400> 679 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 680 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC CDR2 <400> 680 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 681 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC CDR3 <400> 681 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 682 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC CDR1 <400> 682 Thr Ser Gly Met Gly Val Gly 1 5 <210> 683 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC CDR2 <400> 683 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 684 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC CDR3 <400> 684 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 685 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC CDR1 <400> 685 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 686 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC CDR2 <400> 686 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 687 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC CDR3 <400> 687 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 688 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC CDR1 <400> 688 Thr Ser Gly Met Gly Val Gly 1 5 <210> 689 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC CDR2 <400> 689 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 690 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC CDR3 <400> 690 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 691 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC CDR1 <400> 691 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 692 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC CDR2 <400> 692 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 693 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC CDR3 <400> 693 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 694 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC CDR1 <400> 694 Thr Ser Gly Met Gly Val Gly 1 5 <210> 695 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC CDR2 <400> 695 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 696 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC CDR3 <400> 696 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 697 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC CDR1 <400> 697 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 698 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC CDR2 <400> 698 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 699 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC CDR3 <400> 699 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 700 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC CDR1 <400> 700 Thr Ser Gly Met Gly Val Gly 1 5 <210> 701 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC CDR2 <400> 701 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 702 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC CDR3 <400> 702 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 703 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC CDR1 <400> 703 Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 704 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC CDR2 <400> 704 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 705 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC CDR3 <400> 705 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 706 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC CDR1 <400> 706 Thr Ser Gly Met Gly Val Gly 1 5 <210> 707 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC CDR2 <400> 707 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 708 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC CDR3 <400> 708 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 709 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC CDR1 <400> 709 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 710 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC CDR2 <400> 710 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 711 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC CDR3 <400> 711 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 712 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC CDR1 <400> 712 Thr Ser Gly Met Gly Val Gly 1 5 <210> 713 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC CDR2 <400> 713 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 714 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC CDR3 <400> 714 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 715 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.120 LC CDR1 <400> 715 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 716 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.120 LC CDR2 <400> 716 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 717 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.120 LC CDR3 <400> 717 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 718 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.120 HC CDR1 <400> 718 Thr Ser Gly Val Gly Val Gly 1 5 <210> 719 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.120 HC CDR2 <400> 719 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 720 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.120 HC CDR3 <400> 720 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 721 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC CDR1 <400> 721 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 722 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC CDR2 <400> 722 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 723 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC CDR3 <400> 723 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 724 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC CDR1 <400> 724 Thr Ser Gly Met Gly Val Gly 1 5 <210> 725 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC CDR2 <400> 725 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 726 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC CDR3 <400> 726 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 727 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC CDR1 <400> 727 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 728 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC CDR2 <400> 728 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 729 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC CDR3 <400> 729 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 730 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC CDR1 <400> 730 Thr Ser Gly Met Gly Val Gly 1 5 <210> 731 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC CDR2 <400> 731 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 732 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC CDR3 <400> 732 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 733 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC CDR1 <400> 733 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 734 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC CDR2 <400> 734 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 735 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC CDR3 <400> 735 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 736 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC CDR1 <400> 736 Thr Ser Gly Met Gly Val Gly 1 5 <210> 737 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC CDR2 <400> 737 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 738 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC CDR3 <400> 738 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 739 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC CDR1 <400> 739 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 740 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC CDR2 <400> 740 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 741 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC CDR3 <400> 741 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 742 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC CDR1 <400> 742 Thr Ser Gly Val Gly Val Gly 1 5 <210> 743 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC CDR2 <400> 743 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 744 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC CDR3 <400> 744 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 745 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC CDR1 <400> 745 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 746 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC CDR2 <400> 746 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 747 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC CDR3 <400> 747 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 748 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC CDR1 <400> 748 Thr Ser Gly Met Gly Val Gly 1 5 <210> 749 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC CDR2 <400> 749 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 750 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC CDR3 <400> 750 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 751 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC CDR1 <400> 751 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 752 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC CDR2 <400> 752 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 753 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC CDR3 <400> 753 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 754 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC CDR1 <400> 754 Thr Ser Gly Met Gly Val Gly 1 5 <210> 755 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC CDR2 <400> 755 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 756 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC CDR3 <400> 756 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 757 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC CDR1 <400> 757 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 758 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC CDR2 <400> 758 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 759 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC CDR3 <400> 759 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 760 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC CDR1 <400> 760 Thr Ser Gly Val Gly Val Gly 1 5 <210> 761 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC CDR2 <400> 761 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 762 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC CDR3 <400> 762 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 763 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC CDR1 <400> 763 Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Phe Val Ser 1 5 10 <210> 764 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC CDR2 <400> 764 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 765 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC CDR3 <400> 765 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 766 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.128 HC CDR1 <400> 766 Thr Ser Gly Val Gly Val Gly 1 5 <210> 767 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.128 HC CDR2 <400> 767 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 768 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.128 HC CDR3 <400> 768 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 769 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC CDR1 <400> 769 Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 770 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC CDR2 <400> 770 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 771 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC CDR3 <400> 771 Gly Thr Trp Asp Asn Asn Leu Ser Ala Gly Val 1 5 10 <210> 772 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC CDR1 <400> 772 Thr Ser Gly Val Gly Val Gly 1 5 <210> 773 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC CDR2 <400> 773 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 774 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC CDR3 <400> 774 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 775 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.130 LC CDR1 <400> 775 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 776 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.130 LC CDR2 <400> 776 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 777 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.130 LC CDR3 <400> 777 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 778 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.130 HC CDR1 <400> 778 Thr Ser Gly Met Gly Val Gly 1 5 <210> 779 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.130 HC CDR2 <400> 779 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 780 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.130 HC CDR3 <400> 780 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 781 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC CDR1 <400> 781 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 782 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC CDR2 <400> 782 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 783 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC CDR3 <400> 783 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 784 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC CDR1 <400> 784 Thr Ser Gly Val Gly Val Gly 1 5 <210> 785 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC CDR2 <400> 785 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 786 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC CDR3 <400> 786 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 787 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC CDR1 <400> 787 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 788 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC CDR2 <400> 788 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 789 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC CDR3 <400> 789 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 790 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC CDR1 <400> 790 Thr Ser Gly Met Gly Val Gly 1 5 <210> 791 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC CDR2 <400> 791 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 792 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC CDR3 <400> 792 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 793 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC CDR1 <400> 793 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 794 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC CDR2 <400> 794 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 795 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC CDR3 <400> 795 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 796 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC CDR1 <400> 796 Thr Ser Gly Met Gly Val Gly 1 5 <210> 797 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC CDR2 <400> 797 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 798 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC CDR3 <400> 798 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 799 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC CDR1 <400> 799 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 800 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC CDR2 <400> 800 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 801 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC CDR3 <400> 801 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 802 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC CDR1 <400> 802 Thr Ser Gly Met Gly Val Gly 1 5 <210> 803 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC CDR2 <400> 803 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 804 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC CDR3 <400> 804 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 805 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC CDR1 <400> 805 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 806 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC CDR2 <400> 806 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 807 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC CDR3 <400> 807 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 808 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC CDR1 <400> 808 Thr Ser Gly Met Gly Val Gly 1 5 <210> 809 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC CDR2 <400> 809 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 810 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC CDR3 <400> 810 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 811 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC CDR1 <400> 811 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 812 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC CDR2 <400> 812 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 813 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC CDR3 <400> 813 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 814 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC CDR1 <400> 814 Thr Ser Gly Met Gly Val Gly 1 5 <210> 815 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC CDR2 <400> 815 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 816 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC CDR3 <400> 816 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 817 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC CDR1 <400> 817 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 818 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC CDR2 <400> 818 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 819 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC CDR3 <400> 819 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 820 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC CDR1 <400> 820 Thr Ser Gly Val Gly Val Gly 1 5 <210> 821 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC CDR2 <400> 821 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 822 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC CDR3 <400> 822 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 823 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC CDR1 <400> 823 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 824 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC CDR2 <400> 824 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 825 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC CDR3 <400> 825 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 826 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC CDR1 <400> 826 Thr Ser Gly Val Gly Val Gly 1 5 <210> 827 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC CDR2 <400> 827 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 828 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC CDR3 <400> 828 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 829 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC CDR1 <400> 829 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 830 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC CDR2 <400> 830 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 831 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC CDR3 <400> 831 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 832 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC CDR1 <400> 832 Thr Ser Gly Val Gly Val Gly 1 5 <210> 833 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC CDR2 <400> 833 Leu Ile Asp Trp Asp Asp Asn Lys Tyr His Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 834 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC CDR3 <400> 834 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 835 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.140 LC CDR1 <400> 835 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 836 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.140 LC CDR2 <400> 836 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 837 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.140 LC CDR3 <400> 837 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 838 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.140 HC CDR1 <400> 838 Thr Ser Gly Met Gly Val Ser 1 5 <210> 839 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.140 HC CDR2 <400> 839 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 840 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.140 HC CDR3 <400> 840 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 841 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC CDR1 <400> 841 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 842 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC CDR2 <400> 842 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 843 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC CDR3 <400> 843 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 844 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC CDR1 <400> 844 Thr Ser Gly Met Gly Val Gly 1 5 <210> 845 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC CDR2 <400> 845 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 846 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC CDR3 <400> 846 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 847 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC CDR1 <400> 847 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 848 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC CDR2 <400> 848 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 849 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC CDR3 <400> 849 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 850 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC CDR1 <400> 850 Thr Ser Gly Met Gly Val Gly 1 5 <210> 851 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC CDR2 <400> 851 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 852 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC CDR3 <400> 852 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 853 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC CDR1 <400> 853 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 854 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC CDR2 <400> 854 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 855 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC CDR3 <400> 855 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 856 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC CDR1 <400> 856 Thr Ser Gly Val Gly Val Gly 1 5 <210> 857 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC CDR2 <400> 857 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 858 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC CDR3 <400> 858 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 859 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC CDR1 <400> 859 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 860 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC CDR2 <400> 860 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 861 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC CDR3 <400> 861 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 862 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC CDR1 <400> 862 Thr Ser Gly Met Gly Val Gly 1 5 <210> 863 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC CDR2 <400> 863 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 864 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC CDR3 <400> 864 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 865 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC CDR1 <400> 865 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 866 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC CDR2 <400> 866 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 867 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC CDR3 <400> 867 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 868 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC CDR1 <400> 868 Thr Ser Gly Val Gly Val Gly 1 5 <210> 869 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC CDR2 <400> 869 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 870 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC CDR3 <400> 870 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 871 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC CDR1 <400> 871 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 872 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC CDR2 <400> 872 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 873 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC CDR3 <400> 873 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 874 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC CDR1 <400> 874 Thr Ser Gly Met Gly Val Gly 1 5 <210> 875 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC CDR2 <400> 875 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 876 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC CDR3 <400> 876 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 877 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC CDR1 <400> 877 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 878 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC CDR2 <400> 878 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 879 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC CDR3 <400> 879 Gly Thr Trp Asp Ser Ser Leu Ser Gly Gly Val 1 5 10 <210> 880 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC CDR1 <400> 880 Thr Ser Gly Met Gly Val Gly 1 5 <210> 881 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC CDR2 <400> 881 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 882 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC CDR3 <400> 882 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 883 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC CDR1 <400> 883 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 884 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC CDR2 <400> 884 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 885 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC CDR3 <400> 885 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 886 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC CDR1 <400> 886 Thr Ser Gly Met Gly Val Gly 1 5 <210> 887 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC CDR2 <400> 887 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 888 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC CDR3 <400> 888 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 889 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC CDR1 <400> 889 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 890 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC CDR2 <400> 890 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 891 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC CDR3 <400> 891 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 892 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC CDR1 <400> 892 Thr Ser Gly Met Gly Val Gly 1 5 <210> 893 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC CDR2 <400> 893 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 894 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC CDR3 <400> 894 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 895 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC CDR1 <400> 895 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 896 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC CDR2 <400> 896 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 897 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC CDR3 <400> 897 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 898 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC CDR1 <400> 898 Thr Ser Gly Met Gly Val Gly 1 5 <210> 899 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC CDR2 <400> 899 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 900 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC CDR3 <400> 900 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 901 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC CDR1 <400> 901 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 902 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC CDR2 <400> 902 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 903 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC CDR3 <400> 903 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 904 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC CDR1 <400> 904 Thr Ser Gly Val Gly Val Gly 1 5 <210> 905 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC CDR2 <400> 905 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 906 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC CDR3 <400> 906 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 907 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC CDR1 <400> 907 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 908 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC CDR2 <400> 908 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 909 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC CDR3 <400> 909 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 910 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC CDR1 <400> 910 Thr Ser Gly Met Gly Val Gly 1 5 <210> 911 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC CDR2 <400> 911 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 912 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC CDR3 <400> 912 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 913 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC CDR1 <400> 913 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 914 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC CDR2 <400> 914 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 915 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC CDR3 <400> 915 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 916 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC CDR1 <400> 916 Thr Ser Gly Val Gly Val Gly 1 5 <210> 917 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC CDR2 <400> 917 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 918 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC CDR3 <400> 918 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 919 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC CDR1 <400> 919 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 920 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC CDR2 <400> 920 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 921 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC CDR3 <400> 921 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 922 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC CDR1 <400> 922 Thr Ser Gly Val Gly Val Gly 1 5 <210> 923 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC CDR2 <400> 923 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 924 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC CDR3 <400> 924 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 925 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC CDR1 <400> 925 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 926 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC CDR2 <400> 926 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 927 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC CDR3 <400> 927 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 928 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC CDR1 <400> 928 Thr Ser Gly Met Gly Val Gly 1 5 <210> 929 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC CDR2 <400> 929 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 930 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC CDR3 <400> 930 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 931 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC CDR1 <400> 931 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 932 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC CDR2 <400> 932 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 933 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC CDR3 <400> 933 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 934 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC CDR1 <400> 934 Thr Ser Gly Met Gly Val Gly 1 5 <210> 935 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC CDR2 <400> 935 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 936 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC CDR3 <400> 936 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 937 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC CDR1 <400> 937 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 938 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC CDR2 <400> 938 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 939 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC CDR3 <400> 939 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 940 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC CDR1 <400> 940 Thr Ser Gly Val Gly Val Gly 1 5 <210> 941 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC CDR2 <400> 941 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 942 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC CDR3 <400> 942 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 943 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC CDR1 <400> 943 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 944 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC CDR2 <400> 944 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 945 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC CDR3 <400> 945 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 946 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC CDR1 <400> 946 Thr Ser Gly Val Gly Val Gly 1 5 <210> 947 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC CDR2 <400> 947 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 948 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC CDR3 <400> 948 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 949 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC CDR1 <400> 949 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 950 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC CDR2 <400> 950 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 951 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC CDR3 <400> 951 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 952 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC CDR1 <400> 952 Thr Ser Gly Val Gly Val Gly 1 5 <210> 953 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC CDR2 <400> 953 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 954 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC CDR3 <400> 954 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 955 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.160 LC CDR1 <400> 955 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 956 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.160 LC CDR2 <400> 956 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 957 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.160 LC CDR3 <400> 957 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 958 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.160 HC CDR1 <400> 958 Thr Ser Gly Val Gly Val Gly 1 5 <210> 959 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.160 HC CDR2 <400> 959 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 960 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.160 HC CDR3 <400> 960 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 961 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC CDR1 <400> 961 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 962 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC CDR2 <400> 962 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 963 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC CDR3 <400> 963 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 964 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC CDR1 <400> 964 Thr Ser Gly Met Gly Val Gly 1 5 <210> 965 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC CDR2 <400> 965 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 966 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC CDR3 <400> 966 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 967 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC CDR1 <400> 967 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 968 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC CDR2 <400> 968 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 969 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC CDR3 <400> 969 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 970 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC CDR1 <400> 970 Thr Ser Gly Val Gly Val Gly 1 5 <210> 971 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC CDR2 <400> 971 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 972 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC CDR3 <400> 972 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 973 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC CDR1 <400> 973 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 974 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC CDR2 <400> 974 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 975 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC CDR3 <400> 975 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 976 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC CDR1 <400> 976 Thr Ser Gly Met Gly Val Gly 1 5 <210> 977 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC CDR2 <400> 977 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 978 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC CDR3 <400> 978 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 979 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC CDR1 <400> 979 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 980 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC CDR2 <400> 980 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 981 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC CDR3 <400> 981 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 982 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC CDR1 <400> 982 Thr Ser Gly Val Gly Val Gly 1 5 <210> 983 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC CDR2 <400> 983 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 984 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC CDR3 <400> 984 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 985 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC CDR1 <400> 985 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 986 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC CDR2 <400> 986 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 987 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC CDR3 <400> 987 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 988 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC CDR1 <400> 988 Thr Ser Gly Met Gly Val Gly 1 5 <210> 989 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC CDR2 <400> 989 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 990 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC CDR3 <400> 990 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 991 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC CDR1 <400> 991 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 992 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC CDR2 <400> 992 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 993 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC CDR3 <400> 993 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 994 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC CDR1 <400> 994 Thr Ser Gly Met Gly Val Gly 1 5 <210> 995 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC CDR2 <400> 995 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 996 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC CDR3 <400> 996 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 997 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC CDR1 <400> 997 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 998 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC CDR2 <400> 998 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 999 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC CDR3 <400> 999 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1000 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC CDR1 <400> 1000 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1001 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC CDR2 <400> 1001 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1002 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC CDR3 <400> 1002 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1003 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC CDR1 <400> 1003 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1004 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC CDR2 <400> 1004 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1005 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC CDR3 <400> 1005 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1006 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC CDR1 <400> 1006 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1007 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC CDR2 <400> 1007 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1008 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC CDR3 <400> 1008 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1009 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC CDR1 <400> 1009 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 1010 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC CDR2 <400> 1010 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1011 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC CDR3 <400> 1011 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1012 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC CDR1 <400> 1012 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1013 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC CDR2 <400> 1013 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1014 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC CDR3 <400> 1014 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1015 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC CDR1 <400> 1015 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1016 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC CDR2 <400> 1016 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1017 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC CDR3 <400> 1017 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1018 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC CDR1 <400> 1018 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1019 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC CDR2 <400> 1019 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1020 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC CDR3 <400> 1020 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1021 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC CDR1 <400> 1021 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1022 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC CDR2 <400> 1022 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1023 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC CDR3 <400> 1023 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1024 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC CDR1 <400> 1024 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1025 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC CDR2 <400> 1025 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1026 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC CDR3 <400> 1026 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1027 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.172 LC CDR1 <400> 1027 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1028 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.172 LC CDR2 <400> 1028 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1029 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.172 LC CDR3 <400> 1029 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1030 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC CDR1 <400> 1030 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1031 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC CDR2 <400> 1031 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1032 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC CDR3 <400> 1032 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1033 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC CDR1 <400> 1033 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1034 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC CDR2 <400> 1034 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1035 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC CDR3 <400> 1035 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1036 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC CDR1 <400> 1036 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1037 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC CDR2 <400> 1037 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1038 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC CDR3 <400> 1038 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1039 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC CDR1 <400> 1039 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1040 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC CDR2 <400> 1040 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1041 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC CDR3 <400> 1041 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1042 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC CDR1 <400> 1042 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1043 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC CDR2 <400> 1043 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1044 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC CDR3 <400> 1044 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1045 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC CDR1 <400> 1045 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1046 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC CDR2 <400> 1046 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1047 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC CDR3 <400> 1047 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1048 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC CDR1 <400> 1048 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1049 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC CDR2 <400> 1049 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1050 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC CDR3 <400> 1050 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1051 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC CDR1 <400> 1051 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1052 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC CDR2 <400> 1052 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1053 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC CDR3 <400> 1053 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1054 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC CDR1 <400> 1054 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1055 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC CDR2 <400> 1055 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1056 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC CDR3 <400> 1056 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1057 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC CDR1 <400> 1057 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1058 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC CDR2 <400> 1058 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1059 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC CDR3 <400> 1059 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1060 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC CDR1 <400> 1060 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1061 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC CDR2 <400> 1061 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1062 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC CDR3 <400> 1062 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1063 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC CDR1 <400> 1063 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1064 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC CDR2 <400> 1064 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1065 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC CDR3 <400> 1065 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1066 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC CDR1 <400> 1066 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1067 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC CDR2 <400> 1067 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1068 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC CDR3 <400> 1068 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1069 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC CDR1 <400> 1069 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1070 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC CDR2 <400> 1070 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1071 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC CDR3 <400> 1071 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1072 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC CDR1 <400> 1072 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1073 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC CDR2 <400> 1073 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1074 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC CDR3 <400> 1074 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1075 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC CDR1 <400> 1075 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1076 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC CDR2 <400> 1076 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1077 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC CDR3 <400> 1077 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1078 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC CDR1 <400> 1078 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1079 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC CDR2 <400> 1079 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1080 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC CDR3 <400> 1080 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1081 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC CDR1 <400> 1081 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1082 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC CDR2 <400> 1082 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1083 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC CDR3 <400> 1083 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1084 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC CDR1 <400> 1084 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1085 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC CDR2 <400> 1085 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1086 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC CDR3 <400> 1086 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1087 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC CDR1 <400> 1087 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1088 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC CDR2 <400> 1088 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1089 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC CDR3 <400> 1089 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1090 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC CDR1 <400> 1090 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1091 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC CDR2 <400> 1091 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1092 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC CDR3 <400> 1092 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1093 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC CDR1 <400> 1093 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1094 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC CDR2 <400> 1094 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1095 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC CDR3 <400> 1095 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1096 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC CDR1 <400> 1096 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1097 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC CDR2 <400> 1097 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1098 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC CDR3 <400> 1098 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1099 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC CDR1 <400> 1099 Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn Tyr Val Ser 1 5 10 <210> 1100 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC CDR2 <400> 1100 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 1101 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC CDR3 <400> 1101 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1102 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC CDR1 <400> 1102 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1103 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC CDR2 <400> 1103 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1104 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC CDR3 <400> 1104 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1105 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC CDR1 <400> 1105 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1106 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC CDR2 <400> 1106 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1107 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC CDR3 <400> 1107 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1108 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC CDR1 <400> 1108 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1109 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC CDR2 <400> 1109 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1110 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC CDR3 <400> 1110 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1111 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC CDR1 <400> 1111 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1112 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC CDR2 <400> 1112 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1113 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC CDR3 <400> 1113 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1114 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC CDR1 <400> 1114 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1115 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC CDR2 <400> 1115 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1116 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC CDR3 <400> 1116 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1117 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC CDR1 <400> 1117 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1118 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC CDR2 <400> 1118 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1119 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC CDR3 <400> 1119 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1120 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC CDR1 <400> 1120 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1121 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC CDR2 <400> 1121 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1122 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC CDR3 <400> 1122 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1123 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC CDR1 <400> 1123 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1124 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC CDR2 <400> 1124 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1125 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC CDR3 <400> 1125 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1126 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC CDR1 <400> 1126 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1127 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC CDR2 <400> 1127 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1128 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC CDR3 <400> 1128 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1129 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC CDR1 <400> 1129 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1130 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC CDR2 <400> 1130 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1131 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC CDR3 <400> 1131 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1132 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC CDR1 <400> 1132 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1133 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC CDR2 <400> 1133 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1134 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC CDR3 <400> 1134 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1135 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC CDR1 <400> 1135 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1136 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC CDR2 <400> 1136 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1137 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC CDR3 <400> 1137 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1138 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC CDR1 <400> 1138 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1139 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC CDR2 <400> 1139 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1140 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC CDR3 <400> 1140 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1141 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.191 LC CDR1 <400> 1141 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1142 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.191 LC CDR2 <400> 1142 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1143 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.191 LC CDR3 <400> 1143 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1144 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.191 HC CDR1 <400> 1144 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1145 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.191 HC CDR2 <400> 1145 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1146 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.191 HC CDR3 <400> 1146 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1147 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC CDR1 <400> 1147 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1148 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC CDR2 <400> 1148 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1149 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC CDR3 <400> 1149 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1150 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC CDR1 <400> 1150 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1151 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC CDR2 <400> 1151 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1152 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC CDR3 <400> 1152 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1153 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC CDR1 <400> 1153 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1154 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC CDR2 <400> 1154 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1155 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC CDR3 <400> 1155 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1156 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC CDR1 <400> 1156 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1157 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC CDR2 <400> 1157 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1158 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC CDR3 <400> 1158 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1159 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC CDR1 <400> 1159 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1160 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC CDR2 <400> 1160 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1161 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC CDR3 <400> 1161 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1162 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC CDR1 <400> 1162 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1163 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC CDR2 <400> 1163 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1164 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC CDR3 <400> 1164 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1165 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC CDR1 <400> 1165 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 1166 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC CDR2 <400> 1166 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 1167 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC CDR3 <400> 1167 Gln Ser Tyr Asp Ser Ser Asp Trp Val 1 5 <210> 1168 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC CDR1 <400> 1168 Arg Tyr Gly Ile Ser 1 5 <210> 1169 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC CDR2 <400> 1169 Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu Gln 1 5 10 15 Gly <210> 1170 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC CDR3 <400> 1170 Val Leu Gly Ile Ala Val Ala Gly Thr Pro Ile 1 5 10 <210> 1171 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC CDR1 <400> 1171 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1172 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC CDR2 <400> 1172 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1173 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC CDR3 <400> 1173 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1174 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC CDR1 <400> 1174 Ser Tyr Ala Ile Ser 1 5 <210> 1175 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC CDR2 <400> 1175 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1176 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC CDR3 <400> 1176 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1177 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC CDR1 <400> 1177 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1178 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC CDR2 <400> 1178 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1179 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC CDR3 <400> 1179 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Ile 1 5 10 <210> 1180 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC CDR1 <400> 1180 Ser Tyr Ala Ile Ser 1 5 <210> 1181 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC CDR2 <400> 1181 Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1182 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC CDR3 <400> 1182 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1183 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC CDR1 <400> 1183 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1184 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC CDR2 <400> 1184 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1185 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC CDR3 <400> 1185 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1186 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC CDR1 <400> 1186 Ser Tyr Ala Ile Ser 1 5 <210> 1187 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC CDR2 <400> 1187 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1188 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC CDR3 <400> 1188 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1189 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC CDR1 <400> 1189 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1190 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC CDR2 <400> 1190 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1191 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC CDR3 <400> 1191 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Ile 1 5 10 <210> 1192 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC CDR1 <400> 1192 Ser Tyr Ala Ile Ser 1 5 <210> 1193 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC CDR2 <400> 1193 Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1194 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC CDR3 <400> 1194 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1195 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC CDR1 <400> 1195 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1196 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC CDR2 <400> 1196 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1197 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC CDR3 <400> 1197 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1198 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC CDR1 <400> 1198 Ser Tyr Ala Ile Ser 1 5 <210> 1199 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC CDR2 <400> 1199 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1200 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC CDR3 <400> 1200 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1201 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC CDR1 <400> 1201 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1202 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC CDR2 <400> 1202 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1203 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC CDR3 <400> 1203 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1204 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC CDR1 <400> 1204 Ser Tyr Ala Ile Ser 1 5 <210> 1205 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC CDR2 <400> 1205 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1206 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC CDR3 <400> 1206 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp Tyr 1 5 10 15 <210> 1207 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC CDR1 <400> 1207 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1208 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC CDR2 <400> 1208 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1209 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC CDR3 <400> 1209 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1210 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC CDR1 <400> 1210 Ser Tyr Ala Ile Ser 1 5 <210> 1211 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC CDR2 <400> 1211 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1212 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC CDR3 <400> 1212 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp Tyr 1 5 10 15 <210> 1213 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC CDR1 <400> 1213 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1214 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC CDR2 <400> 1214 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1215 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC CDR3 <400> 1215 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1216 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC CDR1 <400> 1216 Arg Phe Ala Met His 1 5 <210> 1217 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC CDR2 <400> 1217 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1218 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC CDR3 <400> 1218 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1219 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC CDR1 <400> 1219 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Thr Val Asn 1 5 10 <210> 1220 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC CDR2 <400> 1220 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1221 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC CDR3 <400> 1221 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1222 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC CDR1 <400> 1222 Arg Phe Ala Met His 1 5 <210> 1223 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC CDR2 <400> 1223 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1224 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC CDR3 <400> 1224 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1225 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC CDR1 <400> 1225 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1226 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC CDR2 <400> 1226 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1227 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC CDR3 <400> 1227 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1228 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC CDR1 <400> 1228 Ser Phe Ala Met His 1 5 <210> 1229 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC CDR2 <400> 1229 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1230 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC CDR3 <400> 1230 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1231 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC CDR1 <400> 1231 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1232 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC CDR2 <400> 1232 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1233 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC CDR3 <400> 1233 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1234 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC CDR1 <400> 1234 Asn Phe Ala Met His 1 5 <210> 1235 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC CDR2 <400> 1235 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1236 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC CDR3 <400> 1236 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1237 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC CDR1 <400> 1237 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1238 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC CDR2 <400> 1238 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1239 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC CDR3 <400> 1239 Ala Thr Trp Asp Asp Ala Leu Ser Gly Trp Val 1 5 10 <210> 1240 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC CDR1 <400> 1240 Arg Phe Ala Met His 1 5 <210> 1241 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC CDR2 <400> 1241 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1242 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC CDR3 <400> 1242 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1243 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC CDR1 <400> 1243 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1244 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC CDR2 <400> 1244 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1245 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC CDR3 <400> 1245 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1246 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC CDR1 <400> 1246 Arg Phe Ala Met His 1 5 <210> 1247 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC CDR2 <400> 1247 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1248 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC CDR3 <400> 1248 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1249 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC CDR1 <400> 1249 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Ala Val Asn 1 5 10 <210> 1250 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC CDR2 <400> 1250 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1251 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC CDR3 <400> 1251 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1252 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC CDR1 <400> 1252 Ser Phe Ala Met His 1 5 <210> 1253 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC CDR2 <400> 1253 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1254 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC CDR3 <400> 1254 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1255 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC CDR1 <400> 1255 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1256 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC CDR2 <400> 1256 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1257 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC CDR3 <400> 1257 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1258 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC CDR1 <400> 1258 Arg Phe Ala Met His 1 5 <210> 1259 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC CDR2 <400> 1259 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1260 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC CDR3 <400> 1260 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1261 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC CDR1 <400> 1261 Ser Gly Ser Arg Ser Asn Ile Gly Gly Asn Thr Val Asn 1 5 10 <210> 1262 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC CDR2 <400> 1262 Gly Asp Asn Gln Arg Pro Ser 1 5 <210> 1263 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC CDR3 <400> 1263 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1264 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC CDR1 <400> 1264 Thr Tyr Ser Met His 1 5 <210> 1265 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC CDR2 <400> 1265 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1266 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC CDR3 <400> 1266 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1267 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC CDR1 <400> 1267 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1268 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC CDR2 <400> 1268 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1269 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC CDR3 <400> 1269 Ala Ala Trp Glu Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1270 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC CDR1 <400> 1270 Asn Phe Ala Met His 1 5 <210> 1271 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC CDR2 <400> 1271 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1272 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC CDR3 <400> 1272 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1273 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC CDR1 <400> 1273 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1274 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC CDR2 <400> 1274 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1275 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC CDR3 <400> 1275 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1276 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC CDR1 <400> 1276 Arg Phe Ala Met His 1 5 <210> 1277 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC CDR2 <400> 1277 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1278 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC CDR3 <400> 1278 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1279 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC CDR1 <400> 1279 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1280 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC CDR2 <400> 1280 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1281 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC CDR3 <400> 1281 Ala Thr Trp Asp Asp Thr Leu Asp Ser Trp Val 1 5 10 <210> 1282 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC CDR1 <400> 1282 Asn Phe Ala Met His 1 5 <210> 1283 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC CDR2 <400> 1283 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1284 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC CDR3 <400> 1284 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1285 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC CDR1 <400> 1285 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1286 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC CDR2 <400> 1286 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1287 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC CDR3 <400> 1287 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1288 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC CDR1 <400> 1288 Ser Phe Ala Met His 1 5 <210> 1289 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC CDR2 <400> 1289 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1290 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC CDR3 <400> 1290 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1291 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC CDR1 <400> 1291 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1292 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC CDR2 <400> 1292 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1293 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC CDR3 <400> 1293 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1294 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC CDR1 <400> 1294 Ser Phe Ala Met His 1 5 <210> 1295 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC CDR2 <400> 1295 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1296 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC CDR3 <400> 1296 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1297 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC CDR1 <400> 1297 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1298 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC CDR2 <400> 1298 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1299 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC CDR3 <400> 1299 Ala Ala Trp Asp Asp Ser Leu Asn Val Trp Val 1 5 10 <210> 1300 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC CDR1 <400> 1300 Arg Phe Ala Met His 1 5 <210> 1301 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC CDR2 <400> 1301 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1302 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC CDR3 <400> 1302 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1303 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC CDR1 <400> 1303 Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn Pro Val Asn 1 5 10 <210> 1304 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC CDR2 <400> 1304 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1305 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC CDR3 <400> 1305 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1306 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC CDR1 <400> 1306 Ser Phe Ala Met His 1 5 <210> 1307 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC CDR2 <400> 1307 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1308 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC CDR3 <400> 1308 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1309 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC CDR1 <400> 1309 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1310 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC CDR2 <400> 1310 Ser Asn Ser Gln Arg Pro Ser 1 5 <210> 1311 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC CDR3 <400> 1311 Ala Gly Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1312 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC CDR1 <400> 1312 Arg Phe Ala Met His 1 5 <210> 1313 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC CDR2 <400> 1313 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1314 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC CDR3 <400> 1314 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1315 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC CDR1 <400> 1315 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1316 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC CDR2 <400> 1316 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1317 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC CDR3 <400> 1317 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1318 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.220 HC CDR1 <400> 1318 Asn Phe Ala Met His 1 5 <210> 1319 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.220 HC CDR2 <400> 1319 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1320 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.220 HC CDR3 <400> 1320 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1321 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC CDR1 <400> 1321 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1322 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC CDR2 <400> 1322 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1323 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC CDR3 <400> 1323 Ala Thr Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1324 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC CDR1 <400> 1324 Arg Phe Ala Met His 1 5 <210> 1325 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC CDR2 <400> 1325 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1326 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC CDR3 <400> 1326 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1327 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC CDR1 <400> 1327 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1328 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC CDR2 <400> 1328 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1329 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC CDR3 <400> 1329 Ala Thr Trp Asp Asp Ala Leu Ser Gly Trp Val 1 5 10 <210> 1330 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC CDR1 <400> 1330 Arg Phe Ala Met His 1 5 <210> 1331 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC CDR2 <400> 1331 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1332 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC CDR3 <400> 1332 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1333 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC CDR1 <400> 1333 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1334 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC CDR2 <400> 1334 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1335 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC CDR3 <400> 1335 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1336 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC CDR1 <400> 1336 Arg Phe Ala Met His 1 5 <210> 1337 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC CDR2 <400> 1337 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1338 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC CDR3 <400> 1338 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1339 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC CDR1 <400> 1339 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1340 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC CDR2 <400> 1340 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1341 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC CDR3 <400> 1341 Ala Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 1342 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC CDR1 <400> 1342 Ser Tyr Ser Met His 1 5 <210> 1343 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC CDR2 <400> 1343 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1344 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC CDR3 <400> 1344 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1345 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC CDR1 <400> 1345 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1346 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC CDR2 <400> 1346 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1347 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC CDR3 <400> 1347 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1348 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC CDR1 <400> 1348 Thr Tyr Ser Met His 1 5 <210> 1349 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC CDR2 <400> 1349 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1350 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC CDR3 <400> 1350 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1351 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC CDR1 <400> 1351 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1352 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC CDR2 <400> 1352 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1353 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC CDR3 <400> 1353 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1354 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC CDR1 <400> 1354 Asn Phe Ala Met His 1 5 <210> 1355 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC CDR2 <400> 1355 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1356 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC CDR3 <400> 1356 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1357 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC CDR1 <400> 1357 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1358 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC CDR2 <400> 1358 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1359 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC CDR3 <400> 1359 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1360 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC CDR1 <400> 1360 Asn Phe Ala Met His 1 5 <210> 1361 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC CDR2 <400> 1361 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1362 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC CDR3 <400> 1362 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1363 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC CDR1 <400> 1363 Ser Gly Ser Ser Ser Asn Val Gly Ser Asn Thr Val Asn 1 5 10 <210> 1364 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC CDR2 <400> 1364 Ser Asn Asp Gln Arg Pro Ser 1 5 <210> 1365 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC CDR3 <400> 1365 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1366 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC CDR1 <400> 1366 Ser Phe Ala Met His 1 5 <210> 1367 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC CDR2 <400> 1367 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1368 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC CDR3 <400> 1368 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1369 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC CDR1 <400> 1369 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1370 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC CDR2 <400> 1370 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1371 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC CDR3 <400> 1371 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1372 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC CDR1 <400> 1372 Arg Phe Ala Met His 1 5 <210> 1373 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC CDR2 <400> 1373 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1374 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC CDR3 <400> 1374 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1375 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC CDR1 <400> 1375 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1376 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC CDR2 <400> 1376 Ser Ser Asn Gln Arg Pro Ser 1 5 <210> 1377 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC CDR3 <400> 1377 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1378 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC CDR1 <400> 1378 Asn Phe Ala Met His 1 5 <210> 1379 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC CDR2 <400> 1379 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1380 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC CDR3 <400> 1380 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1381 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC CDR1 <400> 1381 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1382 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC CDR2 <400> 1382 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1383 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC CDR3 <400> 1383 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1384 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC CDR1 <400> 1384 Ser Phe Ala Met His 1 5 <210> 1385 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC CDR2 <400> 1385 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1386 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC CDR3 <400> 1386 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1387 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC CDR1 <400> 1387 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1388 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC CDR2 <400> 1388 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1389 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC CDR3 <400> 1389 Ala Ala Trp Asp Asp Ser Leu Asn Ala Trp Val 1 5 10 <210> 1390 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC CDR1 <400> 1390 Ser Tyr Ser Met His 1 5 <210> 1391 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC CDR2 <400> 1391 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1392 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC CDR3 <400> 1392 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1393 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.233 LC CDR1 <400> 1393 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1394 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.233 LC CDR2 <400> 1394 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1395 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.233 LC CDR3 <400> 1395 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1396 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.233 HC CDR1 <400> 1396 Arg Phe Ala Met His 1 5 <210> 1397 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.233 HC CDR2 <400> 1397 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1398 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.233 HC CDR3 <400> 1398 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1399 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC CDR1 <400> 1399 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1400 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC CDR2 <400> 1400 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1401 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC CDR3 <400> 1401 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1402 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC CDR1 <400> 1402 Arg Phe Ala Met His 1 5 <210> 1403 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC CDR2 <400> 1403 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1404 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC CDR3 <400> 1404 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1405 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC CDR1 <400> 1405 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1406 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC CDR2 <400> 1406 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1407 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC CDR3 <400> 1407 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1408 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC CDR1 <400> 1408 Ser Tyr Ala Met His 1 5 <210> 1409 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC CDR2 <400> 1409 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1410 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC CDR3 <400> 1410 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1411 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC CDR1 <400> 1411 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1412 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC CDR2 <400> 1412 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1413 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC CDR3 <400> 1413 Gly Thr Trp Asp Ser Asn Ser Glu Thr Trp Val 1 5 10 <210> 1414 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC CDR1 <400> 1414 Thr Tyr Ser Met His 1 5 <210> 1415 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC CDR2 <400> 1415 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1416 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC CDR3 <400> 1416 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1417 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC CDR1 <400> 1417 Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1418 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC CDR2 <400> 1418 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1419 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC CDR3 <400> 1419 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1420 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC CDR1 <400> 1420 Ser Phe Ala Met His 1 5 <210> 1421 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC CDR2 <400> 1421 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1422 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC CDR3 <400> 1422 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1423 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC CDR1 <400> 1423 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1424 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC CDR2 <400> 1424 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1425 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC CDR3 <400> 1425 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1426 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC CDR1 <400> 1426 Thr Tyr Ser Met His 1 5 <210> 1427 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC CDR2 <400> 1427 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1428 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC CDR3 <400> 1428 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1429 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC CDR1 <400> 1429 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Thr Val Asn 1 5 10 <210> 1430 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC CDR2 <400> 1430 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1431 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC CDR3 <400> 1431 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1432 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC CDR1 <400> 1432 Asn Phe Ala Met His 1 5 <210> 1433 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC CDR2 <400> 1433 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1434 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC CDR3 <400> 1434 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1435 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC CDR1 <400> 1435 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1436 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC CDR2 <400> 1436 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1437 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC CDR3 <400> 1437 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1438 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC CDR1 <400> 1438 Asn Phe Ala Met His 1 5 <210> 1439 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC CDR2 <400> 1439 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1440 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC CDR3 <400> 1440 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1441 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.241 LC CDR1 <400> 1441 Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn Ser Val Asn 1 5 10 <210> 1442 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.241 LC CDR2 <400> 1442 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1443 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.241 LC CDR3 <400> 1443 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1444 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.241 HC CDR1 <400> 1444 Ser Phe Ala Met His 1 5 <210> 1445 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.241 HC CDR2 <400> 1445 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1446 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.241 HC CDR3 <400> 1446 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1447 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.242 LC CDR1 <400> 1447 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Thr Val Asn 1 5 10 <210> 1448 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.242 LC CDR2 <400> 1448 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1449 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.242 LC CDR3 <400> 1449 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1450 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.242 HC CDR1 <400> 1450 Ser Phe Ala Met His 1 5 <210> 1451 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.242 HC CDR2 <400> 1451 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Glu Ser Val Lys 1 5 10 15 Gly <210> 1452 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.242 HC CDR3 <400> 1452 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1453 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.243 LC CDR1 <400> 1453 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1454 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.243 LC CDR2 <400> 1454 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1455 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.243 LC CDR3 <400> 1455 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1456 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.243 HC CDR1 <400> 1456 Ser Phe Ala Met His 1 5 <210> 1457 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.243 HC CDR2 <400> 1457 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1458 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.243 HC CDR3 <400> 1458 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1459 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC CDR1 <400> 1459 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1460 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC CDR2 <400> 1460 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1461 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC CDR3 <400> 1461 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1462 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC CDR1 <400> 1462 Asn Phe Ala Met His 1 5 <210> 1463 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC CDR2 <400> 1463 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1464 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC CDR3 <400> 1464 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1465 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC CDR1 <400> 1465 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1466 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC CDR2 <400> 1466 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1467 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC CDR3 <400> 1467 Ala Thr Trp Asp Asp Ser Leu Asn Ala Trp Val 1 5 10 <210> 1468 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC CDR1 <400> 1468 Arg Phe Ala Met His 1 5 <210> 1469 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC CDR2 <400> 1469 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1470 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC CDR3 <400> 1470 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1471 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC CDR1 <400> 1471 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1472 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC CDR2 <400> 1472 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1473 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC CDR3 <400> 1473 Ala Thr Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1474 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC CDR1 <400> 1474 Arg Phe Ala Met His 1 5 <210> 1475 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC CDR2 <400> 1475 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1476 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC CDR3 <400> 1476 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1477 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC CDR1 <400> 1477 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1478 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC CDR2 <400> 1478 Ser Asn Gln Arg Pro Ser 1 5 <210> 1479 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC CDR3 <400> 1479 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1480 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC CDR1 <400> 1480 Arg Phe Ala Met His 1 5 <210> 1481 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC CDR2 <400> 1481 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1482 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC CDR3 <400> 1482 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1483 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC CDR1 <400> 1483 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1484 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC CDR2 <400> 1484 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1485 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC CDR3 <400> 1485 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1486 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC CDR1 <400> 1486 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1487 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC CDR2 <400> 1487 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1488 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC CDR3 <400> 1488 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1489 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC CDR1 <400> 1489 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 1490 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC CDR2 <400> 1490 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 1491 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC CDR3 <400> 1491 Gln Val Trp Asp Gly Ser Ser Asp His Tyr Val 1 5 10 <210> 1492 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC CDR1 <400> 1492 Ser Tyr Ala Met Ser 1 5 <210> 1493 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC CDR2 <400> 1493 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1494 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC CDR3 <400> 1494 Leu Ser His Gly Val Val Gly Ala Gln Asp Ala Phe Asp Ile 1 5 10 <210> 1495 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC CDR1 <400> 1495 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1496 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC CDR2 <400> 1496 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1497 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC CDR3 <400> 1497 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1498 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC CDR1 <400> 1498 Ser Tyr Ala Ile Ser 1 5 <210> 1499 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC CDR2 <400> 1499 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1500 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC CDR3 <400> 1500 Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 1 5 10 <210> 1501 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC CDR1 <400> 1501 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1502 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC CDR2 <400> 1502 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1503 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC CDR3 <400> 1503 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1504 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC CDR1 <400> 1504 Asp Tyr Ala Met His 1 5 <210> 1505 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC CDR2 <400> 1505 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1506 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC CDR3 <400> 1506 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1507 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC CDR1 <400> 1507 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1508 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC CDR2 <400> 1508 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1509 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC CDR3 <400> 1509 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 1510 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC CDR1 <400> 1510 Asp Tyr Ala Met His 1 5 <210> 1511 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC CDR2 <400> 1511 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1512 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC CDR3 <400> 1512 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1513 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC CDR1 <400> 1513 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1514 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC CDR2 <400> 1514 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1515 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC CDR3 <400> 1515 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1516 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC CDR1 <400> 1516 Asp Tyr Ala Met His 1 5 <210> 1517 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC CDR2 <400> 1517 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1518 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC CDR3 <400> 1518 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1519 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC CDR1 <400> 1519 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 1520 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC CDR2 <400> 1520 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 1521 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC CDR3 <400> 1521 Gln Val Trp Asp Ser Ser Ser Asp His Pro Val 1 5 10 <210> 1522 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC CDR1 <400> 1522 Asp Tyr Ala Met His 1 5 <210> 1523 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC CDR2 <400> 1523 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1524 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC CDR3 <400> 1524 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1525 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC CDR1 <400> 1525 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 1526 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC CDR2 <400> 1526 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 1527 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC CDR3 <400> 1527 Gln Ser Tyr Asp Ser Ser Asn His Ala Val 1 5 10 <210> 1528 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC CDR1 <400> 1528 Asp Tyr Ala Met His 1 5 <210> 1529 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC CDR2 <400> 1529 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1530 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC CDR3 <400> 1530 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1531 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC CDR1 <400> 1531 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1532 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC CDR2 <400> 1532 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1533 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC CDR3 <400> 1533 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1534 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC CDR1 <400> 1534 Asp Tyr Ala Met His 1 5 <210> 1535 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC CDR2 <400> 1535 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1536 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC CDR3 <400> 1536 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1537 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC CDR1 <400> 1537 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1538 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC CDR2 <400> 1538 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1539 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC CDR3 <400> 1539 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1540 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC CDR1 <400> 1540 Asp Tyr Ala Met His 1 5 <210> 1541 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC CDR2 <400> 1541 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1542 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC CDR3 <400> 1542 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1543 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC CDR1 <400> 1543 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1544 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC CDR2 <400> 1544 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1545 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC CDR3 <400> 1545 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1546 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC CDR1 <400> 1546 Asp Tyr Ala Met His 1 5 <210> 1547 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC CDR2 <400> 1547 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1548 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC CDR3 <400> 1548 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1549 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC CDR1 <400> 1549 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1550 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC CDR2 <400> 1550 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1551 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC CDR3 <400> 1551 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1552 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC CDR1 <400> 1552 Asp Tyr Ala Met His 1 5 <210> 1553 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC CDR2 <400> 1553 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1554 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC CDR3 <400> 1554 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1555 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC CDR1 <400> 1555 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1556 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC CDR2 <400> 1556 Thr Asn Asn Gln Arg Pro Ser 1 5 <210> 1557 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC CDR3 <400> 1557 Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val 1 5 10 <210> 1558 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC CDR1 <400> 1558 Asp Tyr Ala Met His 1 5 <210> 1559 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC CDR2 <400> 1559 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1560 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC CDR3 <400> 1560 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1561 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC CDR1 <400> 1561 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1562 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC CDR2 <400> 1562 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 1563 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC CDR3 <400> 1563 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val 1 5 10 <210> 1564 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.261 HC CDR1 <400> 1564 Asp Tyr Ala Met His 1 5 <210> 1565 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.261 HC CDR2 <400> 1565 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1566 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.261 HC CDR3 <400> 1566 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1567 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC CDR1 <400> 1567 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1568 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC CDR2 <400> 1568 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1569 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC CDR3 <400> 1569 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Tyr Val 1 5 10 <210> 1570 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC CDR1 <400> 1570 Asp Tyr Ala Met His 1 5 <210> 1571 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC CDR2 <400> 1571 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1572 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC CDR3 <400> 1572 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1573 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC CDR1 <400> 1573 Ser Gly Ser Ser Pro Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1574 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC CDR2 <400> 1574 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1575 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC CDR3 <400> 1575 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val 1 5 10 <210> 1576 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC CDR1 <400> 1576 Asp Tyr Ala Met His 1 5 <210> 1577 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC CDR2 <400> 1577 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1578 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC CDR3 <400> 1578 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1579 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC CDR1 <400> 1579 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1580 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC CDR2 <400> 1580 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1581 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC CDR3 <400> 1581 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val 1 5 10 <210> 1582 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC CDR1 <400> 1582 Asp Tyr Ala Met His 1 5 <210> 1583 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC CDR2 <400> 1583 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1584 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC CDR3 <400> 1584 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1585 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC CDR1 <400> 1585 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1586 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC CDR2 <400> 1586 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1587 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC CDR3 <400> 1587 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val 1 5 10 <210> 1588 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC CDR1 <400> 1588 Ser Asn Tyr Met Thr 1 5 <210> 1589 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC CDR2 <400> 1589 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1590 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC CDR3 <400> 1590 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1591 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC CDR1 <400> 1591 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 1592 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC CDR2 <400> 1592 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 1593 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC CDR3 <400> 1593 Gln Val Arg Asp Ser Ser Ser Asp His Pro Val 1 5 10 <210> 1594 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC CDR1 <400> 1594 Ser Asn Tyr Met Thr 1 5 <210> 1595 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC CDR2 <400> 1595 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1596 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC CDR3 <400> 1596 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1597 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC CDR1 <400> 1597 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1598 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC CDR2 <400> 1598 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1599 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC CDR3 <400> 1599 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val 1 5 10 <210> 1600 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC CDR1 <400> 1600 Ser Asn Tyr Met Thr 1 5 <210> 1601 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC CDR2 <400> 1601 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1602 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC CDR3 <400> 1602 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1603 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC CDR1 <400> 1603 Thr Gly Ser Asp Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1604 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC CDR2 <400> 1604 Asn Asn Asn Asn Arg Pro Ser 1 5 <210> 1605 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC CDR3 <400> 1605 Gln Ser Ser Asp Ser Gly Leu Thr Gly Trp Val 1 5 10 <210> 1606 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC CDR1 <400> 1606 Ser Asn Tyr Met Thr 1 5 <210> 1607 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC CDR2 <400> 1607 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1608 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC CDR3 <400> 1608 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1609 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC CDR1 <400> 1609 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1610 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC CDR2 <400> 1610 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1611 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC CDR3 <400> 1611 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1612 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC CDR1 <400> 1612 Ser Asn Tyr Met Thr 1 5 <210> 1613 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC CDR2 <400> 1613 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1614 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC CDR3 <400> 1614 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1615 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC CDR1 <400> 1615 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 1616 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC CDR2 <400> 1616 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 1617 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC CDR3 <400> 1617 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 1618 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC CDR1 <400> 1618 Ser Asn Tyr Met Thr 1 5 <210> 1619 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC CDR2 <400> 1619 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1620 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC CDR3 <400> 1620 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1621 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC CDR1 <400> 1621 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1622 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC CDR2 <400> 1622 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1623 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC CDR3 <400> 1623 Ser Ser Tyr Ala Gly Ser Asn Asn Leu Val 1 5 10 <210> 1624 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC CDR1 <400> 1624 Ser Asn Tyr Met Thr 1 5 <210> 1625 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC CDR2 <400> 1625 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1626 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC CDR3 <400> 1626 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1627 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC CDR1 <400> 1627 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1628 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC CDR2 <400> 1628 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1629 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC CDR3 <400> 1629 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1630 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC CDR1 <400> 1630 Ser Asn Tyr Met Thr 1 5 <210> 1631 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC CDR2 <400> 1631 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1632 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC CDR3 <400> 1632 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1633 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC CDR1 <400> 1633 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 1634 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC CDR2 <400> 1634 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 1635 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC CDR3 <400> 1635 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 1636 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC CDR1 <400> 1636 Ser Asn Tyr Met Thr 1 5 <210> 1637 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC CDR2 <400> 1637 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1638 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC CDR3 <400> 1638 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1639 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC CDR1 <400> 1639 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1640 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC CDR2 <400> 1640 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1641 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC CDR3 <400> 1641 Gln Ser Tyr Asp Ser Ser Leu Gly Val Val 1 5 10 <210> 1642 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC CDR1 <400> 1642 Ser Asn Tyr Met Thr 1 5 <210> 1643 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC CDR2 <400> 1643 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1644 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC CDR3 <400> 1644 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1645 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC CDR1 <400> 1645 Gly Gly Asn Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1646 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC CDR2 <400> 1646 Ser Asn Asn Leu Arg Pro Ser 1 5 <210> 1647 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC CDR3 <400> 1647 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 1648 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC CDR1 <400> 1648 Ser Asn Tyr Met Thr 1 5 <210> 1649 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC CDR2 <400> 1649 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1650 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC CDR3 <400> 1650 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1651 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC CDR1 <400> 1651 Ser Gly Ser Ser Ser Asn Ile Gly Gly Ser Asp Val Gly 1 5 10 <210> 1652 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC CDR2 <400> 1652 Lys Ser Asn Gln Arg Pro Ser 1 5 <210> 1653 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC CDR3 <400> 1653 Ala Thr Trp Asp Asp Arg Leu Asn Trp Val 1 5 10 <210> 1654 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC CDR1 <400> 1654 Ser Asn Tyr Met Thr 1 5 <210> 1655 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC CDR2 <400> 1655 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1656 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC CDR3 <400> 1656 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1657 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC CDR1 <400> 1657 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 1658 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC CDR2 <400> 1658 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 1659 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC CDR3 <400> 1659 Gln Gln Ser Tyr Ser Thr Pro Phe Thr 1 5 <210> 1660 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC CDR1 <400> 1660 Asn Tyr Tyr Met His 1 5 <210> 1661 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC CDR2 <400> 1661 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1662 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC CDR3 <400> 1662 Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr 1 5 10 <210> 1663 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC CDR1 <400> 1663 Gln Ala Gly Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 1664 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC CDR2 <400> 1664 Lys Ala Ser Ser Leu Glu Ser 1 5 <210> 1665 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC CDR3 <400> 1665 Gln Gln Ala His Ser Phe Pro Phe Thr 1 5 <210> 1666 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC CDR1 <400> 1666 Ser Tyr Tyr Met His 1 5 <210> 1667 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC CDR2 <400> 1667 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1668 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC CDR3 <400> 1668 Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr 1 5 10 <210> 1669 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC CDR1 <400> 1669 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 1670 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC CDR2 <400> 1670 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 1671 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC CDR3 <400> 1671 Gln Gln Ser Tyr Ser Thr Leu Pro Thr 1 5 <210> 1672 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC CDR1 <400> 1672 Ser Tyr Tyr Met His 1 5 <210> 1673 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC CDR2 <400> 1673 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1674 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC CDR3 <400> 1674 Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr 1 5 10 <210> 1675 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC CDR1 <400> 1675 Thr Gly Ser Ser Ser Asn Thr Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1676 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC CDR2 <400> 1676 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1677 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC CDR3 <400> 1677 Ala Ala Trp Asp Asp Ser Leu Asn Gly Gly Val 1 5 10 <210> 1678 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC CDR1 <400> 1678 Ser Asn Tyr Met Ser 1 5 <210> 1679 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC CDR2 <400> 1679 Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1680 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC CDR3 <400> 1680 Asp Leu Ile Val Tyr Gly Met Asp Val 1 5 <210> 1681 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.281 LC CDR1 <400> 1681 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1682 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.281 LC CDR2 <400> 1682 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1683 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.281 LC CDR3 <400> 1683 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1684 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.281 HC CDR1 <400> 1684 Ser Asn Tyr Met Ser 1 5 <210> 1685 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.281 HC CDR2 <400> 1685 Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1686 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.281 HC CDR3 <400> 1686 Asp Leu Ile Val Tyr Gly Met Asp Val 1 5 <210> 1687 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC CDR1 <400> 1687 Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1688 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC CDR2 <400> 1688 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1689 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC CDR3 <400> 1689 Ala Ala Trp Asp Asp Ser Leu Asn Gly Gly Val 1 5 10 <210> 1690 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC CDR1 <400> 1690 Ser Asn Tyr Met Ser 1 5 <210> 1691 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC CDR2 <400> 1691 Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1692 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC CDR3 <400> 1692 Asp Leu Ile Val Tyr Gly Met Asp Val 1 5 <210> 1693 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC CDR1 <400> 1693 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 1694 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC CDR2 <400> 1694 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 1695 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC CDR3 <400> 1695 Gln Gln Tyr Gly Ser Ser Pro Pro Tyr Thr 1 5 10 <210> 1696 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC CDR1 <400> 1696 Ser Asn Tyr Met Ser 1 5 <210> 1697 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC CDR2 <400> 1697 Val Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1698 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC CDR3 <400> 1698 Asp Leu Arg Gly Val Leu Asp Tyr 1 5 <210> 1699 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC CDR1 <400> 1699 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1700 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC CDR2 <400> 1700 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1701 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC CDR3 <400> 1701 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1702 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC CDR1 <400> 1702 Ser Asn Tyr Met Ser 1 5 <210> 1703 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC CDR2 <400> 1703 Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1704 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC CDR3 <400> 1704 Gly His Val Asp Ile Pro Tyr Gly Met Asp Val 1 5 10 <210> 1705 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC CDR1 <400> 1705 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1706 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC CDR2 <400> 1706 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1707 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC CDR3 <400> 1707 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1708 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC CDR1 <400> 1708 Ser Tyr Ala Ile Ser 1 5 <210> 1709 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC CDR2 <400> 1709 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1710 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC CDR3 <400> 1710 Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp Pro 1 5 10 15 <210> 1711 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC CDR1 <400> 1711 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1712 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC CDR2 <400> 1712 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1713 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC CDR3 <400> 1713 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1714 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC CDR1 <400> 1714 Ser Tyr Ala Ile Ser 1 5 <210> 1715 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC CDR2 <400> 1715 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1716 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC CDR3 <400> 1716 Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp Pro 1 5 10 15 <210> 1717 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC CDR1 <400> 1717 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1718 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC CDR2 <400> 1718 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1719 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC CDR3 <400> 1719 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1720 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC CDR1 <400> 1720 Ser Tyr Ala Ile Ser 1 5 <210> 1721 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC CDR2 <400> 1721 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1722 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC CDR3 <400> 1722 Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 1 5 10 <210> 1723 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC CDR1 <400> 1723 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 1724 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC CDR2 <400> 1724 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 1725 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC CDR3 <400> 1725 Gln Ser Tyr Asp Ser Ser Asn His Trp Val 1 5 10 <210> 1726 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC CDR1 <400> 1726 Ser Tyr Ala Met His 1 5 <210> 1727 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC CDR2 <400> 1727 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1728 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC CDR3 <400> 1728 Ala Asn Leu Gly Tyr Cys Thr Asn Gly Val Cys Ala Pro Ser Gly Gly 1 5 10 15 <210> 1729 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC CDR1 <400> 1729 Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1730 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC CDR2 <400> 1730 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1731 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC CDR3 <400> 1731 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 1732 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC CDR1 <400> 1732 Asp Tyr Ala Met His 1 5 <210> 1733 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC CDR2 <400> 1733 Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1734 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC CDR3 <400> 1734 Asn Leu Arg Tyr Phe Asp Trp Leu Leu Gly Asp Asp Ala Phe Asp Ile 1 5 10 15 <210> 1735 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC CDR1 <400> 1735 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1736 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC CDR2 <400> 1736 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1737 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC CDR3 <400> 1737 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1738 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC CDR1 <400> 1738 Ser Asn Tyr Met Thr 1 5 <210> 1739 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC CDR2 <400> 1739 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1740 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC CDR3 <400> 1740 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1741 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.1 LC variable region <400> 1741 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1742 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.1 HC variable region <400> 1742 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu 100 105 110 Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 1743 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.2 LC variable region <400> 1743 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Val Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro His 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1744 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.2 HC variable region <400> 1744 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu 100 105 110 Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 1745 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.3 LC variable region <400> 1745 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1746 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.3 HC variable region <400> 1746 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr 100 105 110 Ser Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1747 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.4 LC variable region <400> 1747 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asp Leu Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1748 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.4 HC variable region <400> 1748 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr 100 105 110 Ser Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1749 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.5 LC variable region <400> 1749 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1750 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.5 HC variable region <400> 1750 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr 100 105 110 Ser Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1751 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.6 LC variable region <400> 1751 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1752 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.6 HC variable region <400> 1752 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1753 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.7 LC variable region <400> 1753 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1754 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.7 HC variable region <400> 1754 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1755 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC variable region <400> 1755 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1756 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC variable region <400> 1756 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1757 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.9 LC variable region <400> 1757 Glu Leu Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1758 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.9 HC variable region <400> 1758 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1759 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC variable region <400> 1759 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1760 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC variable region <400> 1760 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1761 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.11 LC variable region <400> 1761 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1762 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.11 HC variable region <400> 1762 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1763 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.12 LC variable region <400> 1763 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1764 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.12 HC variable region <400> 1764 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1765 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.13 LC variable region <400> 1765 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Gly Asn Tyr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1766 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.13 HC variable region <400> 1766 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1767 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.14 LC variable region <400> 1767 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 20 25 30 Tyr Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Arg Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1768 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.14 HC variable region <400> 1768 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1769 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.15 LC variable region <400> 1769 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1770 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.15 HC variable region <400> 1770 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1771 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC variable region <400> 1771 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1772 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC variable region <400> 1772 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1773 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC variable region <400> 1773 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1774 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC variable region <400> 1774 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1775 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.18 LC variable region <400> 1775 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1776 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.18 HC variable region <400> 1776 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1777 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC variable region <400> 1777 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1778 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.19 HC variable region <400> 1778 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1779 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.20 LC variable region <400> 1779 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1780 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.20 HC variable region <400> 1780 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1781 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC variable region <400> 1781 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1782 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC variable region <400> 1782 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1783 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.22 LC variable region <400> 1783 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1784 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.22 HC variable region <400> 1784 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1785 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC variable region <400> 1785 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1786 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.23 HC variable region <400> 1786 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1787 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.24 LC variable region <400> 1787 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1788 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.24 HC variable region <400> 1788 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1789 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC variable region <400> 1789 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1790 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC variable region <400> 1790 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1791 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC variable region <400> 1791 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1792 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC variable region <400> 1792 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1793 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC variable region <400> 1793 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1794 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC variable region <400> 1794 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1795 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC variable region <400> 1795 Glu Leu Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1796 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC variable region <400> 1796 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1797 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC variable region <400> 1797 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1798 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC variable region <400> 1798 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1799 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.30 LC variable region <400> 1799 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1800 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.30 HC variable region <400> 1800 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1801 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.31 LC variable region <400> 1801 Glu Leu Gly Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 20 25 30 Tyr Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1802 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.31 HC variable region <400> 1802 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1803 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC variable region <400> 1803 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1804 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC variable region <400> 1804 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1805 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC variable region <400> 1805 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1806 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC variable region <400> 1806 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1807 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC variable region <400> 1807 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1808 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC variable region <400> 1808 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1809 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC variable region <400> 1809 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1810 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC variable region <400> 1810 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1811 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC variable region <400> 1811 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1812 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC variable region <400> 1812 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1813 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC variable region <400> 1813 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1814 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC variable region <400> 1814 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1815 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC variable region <400> 1815 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1816 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.38 HC variable region <400> 1816 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1817 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC variable region <400> 1817 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1818 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC variable region <400> 1818 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1819 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.40 LC variable region <400> 1819 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1820 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.40 HC variable region <400> 1820 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1821 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC variable region <400> 1821 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1822 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC variable region <400> 1822 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1823 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC variable region <400> 1823 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1824 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC variable region <400> 1824 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1825 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC variable region <400> 1825 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1826 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC variable region <400> 1826 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1827 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC variable region <400> 1827 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Val Thr Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1828 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC variable region <400> 1828 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Arg Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Pro Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1829 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC variable region <400> 1829 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1830 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC variable region <400> 1830 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1831 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC variable region <400> 1831 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1832 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC variable region <400> 1832 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1833 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC variable region <400> 1833 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1834 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC variable region <400> 1834 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1835 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC variable region <400> 1835 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1836 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC variable region <400> 1836 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Ser His Tyr 20 25 30 Phe Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly 100 105 110 Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1837 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.49 LC variable region <400> 1837 Glu Leu Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1838 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.49 HC variable region <400> 1838 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1839 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC variable region <400> 1839 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1840 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC variable region <400> 1840 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1841 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC variable region <400> 1841 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1842 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC variable region <400> 1842 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1843 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.52 LC variable region <400> 1843 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1844 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.52 HC variable region <400> 1844 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1845 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC variable region <400> 1845 Glu Leu Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Gly Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Ala Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1846 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC variable region <400> 1846 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1847 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC variable region <400> 1847 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Ala Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr His Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1848 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC variable region <400> 1848 Arg Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1849 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC variable region <400> 1849 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1850 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC variable region <400> 1850 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1851 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC variable region <400> 1851 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 1852 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC variable region <400> 1852 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1853 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.57 LC variable region <400> 1853 Glu Leu Val Met Thr Gln Ser Pro Gly Ile Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1854 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.57 HC variable region <400> 1854 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1855 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.58 LC variable region <400> 1855 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1856 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.58 HC variable region <400> 1856 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1857 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC variable region <400> 1857 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1858 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC variable region <400> 1858 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1859 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC variable region <400> 1859 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Pro Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1860 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.60 HC variable region <400> 1860 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1861 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC variable region <400> 1861 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Ser 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1862 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC variable region <400> 1862 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1863 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC variable region <400> 1863 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1864 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC variable region <400> 1864 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1865 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC variable region <400> 1865 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1866 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC variable region <400> 1866 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Val Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1867 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC variable region <400> 1867 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1868 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC variable region <400> 1868 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1869 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC variable region <400> 1869 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Ser Ala Thr Leu Ala Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Phe Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 1870 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC variable region <400> 1870 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1871 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC variable region <400> 1871 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1872 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC variable region <400> 1872 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1873 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC variable region <400> 1873 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1874 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC variable region <400> 1874 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1875 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC variable region <400> 1875 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Pro Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 1876 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC variable region <400> 1876 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Val Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1877 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC variable region <400> 1877 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile His Ala Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Val Glu 65 70 75 80 Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asp Ser Leu 85 90 95 Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1878 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC variable region <400> 1878 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1879 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.70 LC variable region <400> 1879 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1880 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.70 HC variable region <400> 1880 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1881 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC variable region <400> 1881 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1882 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC variable region <400> 1882 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1883 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC variable region <400> 1883 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met 35 40 45 Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 65 70 75 80 Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser Ser 85 90 95 Thr Leu Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 <210> 1884 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC variable region <400> 1884 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1885 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC variable region <400> 1885 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Ser Ala Thr Leu Ala Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Phe Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 1886 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC variable region <400> 1886 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Pro Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1887 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC variable region <400> 1887 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1888 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC variable region <400> 1888 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1889 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC variable region <400> 1889 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1890 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC variable region <400> 1890 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1891 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC variable region <400> 1891 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1892 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC variable region <400> 1892 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1893 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC variable region <400> 1893 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1894 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC variable region <400> 1894 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1895 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC variable region <400> 1895 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1896 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC variable region <400> 1896 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1897 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC variable region <400> 1897 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Ser 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1898 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC variable region <400> 1898 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1899 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC variable region <400> 1899 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1900 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC variable region <400> 1900 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1901 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC variable region <400> 1901 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1902 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC variable region <400> 1902 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1903 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC variable region <400> 1903 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1904 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC variable region <400> 1904 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1905 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC variable region <400> 1905 Glu Leu Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1906 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC variable region <400> 1906 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1907 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC variable region <400> 1907 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1908 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC variable region <400> 1908 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Val Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1909 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC variable region <400> 1909 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1910 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC variable region <400> 1910 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1911 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC variable region <400> 1911 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Arg Ala Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1912 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC variable region <400> 1912 Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1913 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC variable region <400> 1913 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1914 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC variable region <400> 1914 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1915 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC variable region <400> 1915 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1916 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC variable region <400> 1916 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 1917 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC variable region <400> 1917 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Arg Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1918 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC variable region <400> 1918 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1919 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC variable region <400> 1919 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1920 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC variable region <400> 1920 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1921 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC variable region <400> 1921 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1922 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC variable region <400> 1922 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ala Gln 1 5 10 15 Thr Leu Arg Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Phe Ser 115 120 125 <210> 1923 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC variable region <400> 1923 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1924 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC variable region <400> 1924 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1925 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC variable region <400> 1925 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Arg Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1926 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC variable region <400> 1926 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Val Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1927 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC variable region <400> 1927 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1928 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC variable region <400> 1928 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1929 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC variable region <400> 1929 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1930 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC variable region <400> 1930 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1931 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.96 LC variable region <400> 1931 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1932 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.96 HC variable region <400> 1932 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1933 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC variable region <400> 1933 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1934 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC variable region <400> 1934 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1935 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.98 LC variable region <400> 1935 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1936 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.98 HC variable region <400> 1936 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1937 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC variable region <400> 1937 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1938 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC variable region <400> 1938 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1939 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC variable region <400> 1939 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1940 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.100 HC variable region <400> 1940 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1941 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.101 LC variable region <400> 1941 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1942 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.101 HC variable region <400> 1942 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1943 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC variable region <400> 1943 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1944 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC variable region <400> 1944 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1945 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC variable region <400> 1945 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1946 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC variable region <400> 1946 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1947 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC variable region <400> 1947 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1948 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC variable region <400> 1948 Gln Val Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1949 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC variable region <400> 1949 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1950 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC variable region <400> 1950 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1951 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC variable region <400> 1951 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1952 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC variable region <400> 1952 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1953 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC variable region <400> 1953 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1954 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC variable region <400> 1954 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1955 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC variable region <400> 1955 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1956 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC variable region <400> 1956 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1957 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC variable region <400> 1957 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1958 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC variable region <400> 1958 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1959 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC variable region <400> 1959 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1960 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.110 HC variable region <400> 1960 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1961 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC variable region <400> 1961 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1962 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC variable region <400> 1962 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1963 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC variable region <400> 1963 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1964 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC variable region <400> 1964 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1965 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC variable region <400> 1965 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Ile Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1966 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC variable region <400> 1966 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1967 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC variable region <400> 1967 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1968 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC variable region <400> 1968 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1969 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC variable region <400> 1969 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1970 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC variable region <400> 1970 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1971 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC variable region <400> 1971 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1972 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC variable region <400> 1972 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1973 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC variable region <400> 1973 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1974 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC variable region <400> 1974 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1975 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC variable region <400> 1975 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1976 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC variable region <400> 1976 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1977 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC variable region <400> 1977 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1978 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC variable region <400> 1978 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1979 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.120 LC variable region <400> 1979 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1980 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.120 HC variable region <400> 1980 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Thr Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1981 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC variable region <400> 1981 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1982 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC variable region <400> 1982 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1983 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC variable region <400> 1983 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1984 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC variable region <400> 1984 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1985 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC variable region <400> 1985 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1986 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC variable region <400> 1986 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1987 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC variable region <400> 1987 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1988 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC variable region <400> 1988 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ala Gln 1 5 10 15 Thr Leu Arg Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Phe Ser 115 120 125 <210> 1989 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC variable region <400> 1989 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1990 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC variable region <400> 1990 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1991 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC variable region <400> 1991 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1992 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC variable region <400> 1992 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1993 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC variable region <400> 1993 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1994 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC variable region <400> 1994 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ala Gln 1 5 10 15 Thr Leu Arg Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Phe Ser 115 120 125 <210> 1995 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC variable region <400> 1995 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn 20 25 30 Phe Val Ser Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1996 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.128 HC variable region <400> 1996 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1997 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC variable region <400> 1997 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Ser Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Asn Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1998 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC variable region <400> 1998 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1999 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.130 LC variable region <400> 1999 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2000 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.130 HC variable region <400> 2000 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2001 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC variable region <400> 2001 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2002 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC variable region <400> 2002 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2003 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC variable region <400> 2003 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2004 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC variable region <400> 2004 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2005 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC variable region <400> 2005 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2006 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC variable region <400> 2006 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2007 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC variable region <400> 2007 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2008 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC variable region <400> 2008 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2009 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC variable region <400> 2009 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2010 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC variable region <400> 2010 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2011 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC variable region <400> 2011 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2012 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC variable region <400> 2012 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2013 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC variable region <400> 2013 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2014 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC variable region <400> 2014 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2015 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC variable region <400> 2015 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2016 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC variable region <400> 2016 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2017 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC variable region <400> 2017 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2018 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC variable region <400> 2018 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr His Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2019 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.140 LC variable region <400> 2019 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2020 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.140 HC variable region <400> 2020 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2021 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC variable region <400> 2021 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2022 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC variable region <400> 2022 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2023 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC variable region <400> 2023 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2024 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC variable region <400> 2024 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2025 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC variable region <400> 2025 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2026 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC variable region <400> 2026 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2027 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC variable region <400> 2027 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2028 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC variable region <400> 2028 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2029 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC variable region <400> 2029 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2030 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC variable region <400> 2030 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2031 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC variable region <400> 2031 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2032 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC variable region <400> 2032 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2033 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC variable region <400> 2033 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2034 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC variable region <400> 2034 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Phe Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2035 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC variable region <400> 2035 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2036 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC variable region <400> 2036 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2037 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC variable region <400> 2037 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2038 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC variable region <400> 2038 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2039 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC variable region <400> 2039 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2040 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC variable region <400> 2040 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2041 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC variable region <400> 2041 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2042 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC variable region <400> 2042 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2043 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC variable region <400> 2043 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2044 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC variable region <400> 2044 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2045 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC variable region <400> 2045 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2046 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC variable region <400> 2046 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2047 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC variable region <400> 2047 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2048 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC variable region <400> 2048 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2049 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC variable region <400> 2049 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2050 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC variable region <400> 2050 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2051 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC variable region <400> 2051 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2052 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC variable region <400> 2052 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2053 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC variable region <400> 2053 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2054 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC variable region <400> 2054 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2055 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC variable region <400> 2055 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2056 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC variable region <400> 2056 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2057 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC variable region <400> 2057 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2058 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC variable region <400> 2058 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2059 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.160 LC variable region <400> 2059 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2060 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.160 HC variable region <400> 2060 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2061 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC variable region <400> 2061 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2062 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC variable region <400> 2062 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2063 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC variable region <400> 2063 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2064 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC variable region <400> 2064 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2065 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC variable region <400> 2065 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2066 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC variable region <400> 2066 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2067 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC variable region <400> 2067 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2068 <211> 133 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC variable region <400> 2068 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Pro Arg Asp His Gly His Arg Leu Leu 115 120 125 Ser Phe His Gln Gly 130 <210> 2069 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC variable region <400> 2069 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2070 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC variable region <400> 2070 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2071 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC variable region <400> 2071 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2072 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC variable region <400> 2072 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2073 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC variable region <400> 2073 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2074 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC variable region <400> 2074 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2075 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC variable region <400> 2075 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2076 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC variable region <400> 2076 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2077 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC variable region <400> 2077 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2078 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC variable region <400> 2078 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2079 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC variable region <400> 2079 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2080 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC variable region <400> 2080 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2081 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC variable region <400> 2081 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2082 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC variable region <400> 2082 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2083 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.172 LC variable region <400> 2083 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Ala Leu 100 105 110 <210> 2084 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC variable region <400> 2084 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Pro Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2085 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC variable region <400> 2085 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2086 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC variable region <400> 2086 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2087 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC variable region <400> 2087 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2088 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC variable region <400> 2088 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2089 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC variable region <400> 2089 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2090 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC variable region <400> 2090 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2091 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC variable region <400> 2091 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2092 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC variable region <400> 2092 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2093 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC variable region <400> 2093 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2094 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC variable region <400> 2094 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2095 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC variable region <400> 2095 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2096 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC variable region <400> 2096 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2097 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC variable region <400> 2097 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2098 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC variable region <400> 2098 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2099 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC variable region <400> 2099 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2100 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC variable region <400> 2100 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2101 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC variable region <400> 2101 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2102 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC variable region <400> 2102 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2103 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC variable region <400> 2103 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2104 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC variable region <400> 2104 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2105 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC variable region <400> 2105 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2106 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC variable region <400> 2106 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2107 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC variable region <400> 2107 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Arg Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2108 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC variable region <400> 2108 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2109 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC variable region <400> 2109 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2110 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC variable region <400> 2110 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2111 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC variable region <400> 2111 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2112 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC variable region <400> 2112 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2113 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC variable region <400> 2113 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2114 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC variable region <400> 2114 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2115 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC variable region <400> 2115 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2116 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC variable region <400> 2116 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2117 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC variable region <400> 2117 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2118 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC variable region <400> 2118 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2119 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC variable region <400> 2119 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2120 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC variable region <400> 2120 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2121 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.191 LC variable region <400> 2121 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2122 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.191 HC variable region <400> 2122 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2123 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC variable region <400> 2123 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2124 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC variable region <400> 2124 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2125 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC variable region <400> 2125 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2126 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC variable region <400> 2126 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2127 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC variable region <400> 2127 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2128 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC variable region <400> 2128 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2129 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC variable region <400> 2129 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asp Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2130 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC variable region <400> 2130 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Thr Arg Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Leu Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Gly Ile Ala Val Ala Gly Thr Pro Ile Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2131 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC variable region <400> 2131 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2132 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC variable region <400> 2132 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2133 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC variable region <400> 2133 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2134 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC variable region <400> 2134 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Glu Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2135 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC variable region <400> 2135 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Ala Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2136 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC variable region <400> 2136 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2137 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC variable region <400> 2137 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2138 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC variable region <400> 2138 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Glu Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2139 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC variable region <400> 2139 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2140 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC variable region <400> 2140 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2141 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC variable region <400> 2141 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2142 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC variable region <400> 2142 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2143 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC variable region <400> 2143 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2144 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC variable region <400> 2144 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2145 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC variable region <400> 2145 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2146 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC variable region <400> 2146 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2147 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC variable region <400> 2147 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2148 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC variable region <400> 2148 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2149 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC variable region <400> 2149 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2150 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC variable region <400> 2150 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2151 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC variable region <400> 2151 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2152 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC variable region <400> 2152 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2153 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC variable region <400> 2153 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ala Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2154 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC variable region <400> 2154 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2155 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC variable region <400> 2155 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2156 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC variable region <400> 2156 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2157 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC variable region <400> 2157 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Ala Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2158 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC variable region <400> 2158 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2159 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC variable region <400> 2159 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2160 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC variable region <400> 2160 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2161 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC variable region <400> 2161 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Gly Asn 20 25 30 Thr Val Asn Trp Phe Gln Gln Leu Pro Gly Ala Val Pro Lys Leu Leu 35 40 45 Val Tyr Gly Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2162 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC variable region <400> 2162 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2163 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC variable region <400> 2163 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Glu Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2164 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC variable region <400> 2164 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Arg Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2165 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC variable region <400> 2165 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2166 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC variable region <400> 2166 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2167 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC variable region <400> 2167 Glu Leu Met Leu Thr Gln Pro His Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Thr Leu 85 90 95 Asp Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2168 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC variable region <400> 2168 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Pro Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2169 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC variable region <400> 2169 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2170 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC variable region <400> 2170 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2171 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC variable region <400> 2171 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2172 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC variable region <400> 2172 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2173 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC variable region <400> 2173 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Val Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2174 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC variable region <400> 2174 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2175 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC variable region <400> 2175 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Ser Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn 20 25 30 Pro Val Asn Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asn Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2176 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC variable region <400> 2176 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2177 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC variable region <400> 2177 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Phe Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Val Ser 50 55 60 Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Gly Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2178 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC variable region <400> 2178 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2179 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC variable region <400> 2179 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2180 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.220 HC variable region <400> 2180 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Pro Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2181 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC variable region <400> 2181 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2182 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC variable region <400> 2182 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2183 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC variable region <400> 2183 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ala Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2184 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC variable region <400> 2184 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2185 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC variable region <400> 2185 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2186 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC variable region <400> 2186 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2187 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC variable region <400> 2187 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2188 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC variable region <400> 2188 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2189 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC variable region <400> 2189 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2190 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC variable region <400> 2190 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2191 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC variable region <400> 2191 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2192 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC variable region <400> 2192 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2193 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC variable region <400> 2193 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2194 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC variable region <400> 2194 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2195 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC variable region <400> 2195 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Leu Ser Cys Ser Gly Ser Ser Ser Asn Val Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2196 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC variable region <400> 2196 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2197 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC variable region <400> 2197 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2198 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC variable region <400> 2198 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2199 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC variable region <400> 2199 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2200 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC variable region <400> 2200 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2201 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC variable region <400> 2201 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2202 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC variable region <400> 2202 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2203 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC variable region <400> 2203 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2204 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC variable region <400> 2204 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2205 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.233 LC variable region <400> 2205 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2206 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.233 HC variable region <400> 2206 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2207 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC variable region <400> 2207 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2208 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC variable region <400> 2208 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2209 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC variable region <400> 2209 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2210 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC variable region <400> 2210 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2211 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC variable region <400> 2211 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Asn Ser 85 90 95 Glu Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2212 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC variable region <400> 2212 Glu Val Gln Leu Leu Glu Ser Arg Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2213 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC variable region <400> 2213 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2214 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC variable region <400> 2214 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2215 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC variable region <400> 2215 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2216 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC variable region <400> 2216 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2217 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC variable region <400> 2217 Asp Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Met Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2218 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC variable region <400> 2218 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2219 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC variable region <400> 2219 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2220 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC variable region <400> 2220 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Pro Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2221 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.241 LC variable region <400> 2221 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn 20 25 30 Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Leu Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2222 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.241 HC variable region <400> 2222 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2223 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.242 LC variable region <400> 2223 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2224 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.242 HC variable region <400> 2224 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Glu Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2225 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.243 LC variable region <400> 2225 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2226 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.243 HC variable region <400> 2226 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2227 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC variable region <400> 2227 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2228 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC variable region <400> 2228 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2229 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC variable region <400> 2229 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2230 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC variable region <400> 2230 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2231 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC variable region <400> 2231 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Pro Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2232 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC variable region <400> 2232 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2233 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC variable region <400> 2233 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser 65 70 75 80 Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser 85 90 95 Gly Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 <210> 2234 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC variable region <400> 2234 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2235 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC variable region <400> 2235 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2236 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC variable region <400> 2236 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Thr Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2237 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC variable region <400> 2237 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Gly Ser Ser Asp His 85 90 95 Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 <210> 2238 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC variable region <400> 2238 Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 1 5 10 15 Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 35 40 45 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Lys Leu Ser His Gly Val Val Gly Ala Gln Asp Ala Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 2239 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC variable region <400> 2239 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2240 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC variable region <400> 2240 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2241 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC variable region <400> 2241 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2242 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC variable region <400> 2242 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2243 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC variable region <400> 2243 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2244 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC variable region <400> 2244 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2245 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC variable region <400> 2245 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2246 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC variable region <400> 2246 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2247 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC variable region <400> 2247 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 85 90 95 Pro Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 <210> 2248 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC variable region <400> 2248 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2249 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC variable region <400> 2249 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asn His Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 100 105 110 <210> 2250 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC variable region <400> 2250 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2251 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC variable region <400> 2251 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2252 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC variable region <400> 2252 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2253 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC variable region <400> 2253 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2254 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC variable region <400> 2254 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2255 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC variable region <400> 2255 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2256 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC variable region <400> 2256 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2257 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC variable region <400> 2257 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2258 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC variable region <400> 2258 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2259 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC variable region <400> 2259 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Leu Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2260 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC variable region <400> 2260 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Ile Val Ser Ser 115 120 <210> 2261 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC variable region <400> 2261 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2262 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.261 HC variable region <400> 2262 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2263 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC variable region <400> 2263 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 85 90 95 Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2264 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC variable region <400> 2264 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2265 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC variable region <400> 2265 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Pro Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2266 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC variable region <400> 2266 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2267 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC variable region <400> 2267 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2268 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC variable region <400> 2268 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2269 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC variable region <400> 2269 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2270 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC variable region <400> 2270 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2271 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC variable region <400> 2271 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Arg Asp Ser Ser Ser Asp His 85 90 95 Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 2272 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC variable region <400> 2272 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2273 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC variable region <400> 2273 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2274 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC variable region <400> 2274 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2275 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC variable region <400> 2275 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Asp Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Asn Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Gln Ser Ser Asp Ser Gly 85 90 95 Leu Thr Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2276 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC variable region <400> 2276 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2277 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC variable region <400> 2277 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ala Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2278 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC variable region <400> 2278 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2279 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC variable region <400> 2279 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2280 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC variable region <400> 2280 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2281 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC variable region <400> 2281 Glu Leu Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Asn 85 90 95 Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> 2282 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC variable region <400> 2282 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2283 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC variable region <400> 2283 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2284 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC variable region <400> 2284 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2285 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC variable region <400> 2285 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2286 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC variable region <400> 2286 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2287 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC variable region <400> 2287 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2288 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC variable region <400> 2288 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2289 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC variable region <400> 2289 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Asn Thr Val 20 25 30 Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 35 40 45 Ser Asn Asn Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 50 55 60 Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly 85 90 95 Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 2290 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC variable region <400> 2290 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2291 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC variable region <400> 2291 Glu Leu Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Ser 20 25 30 Asp Val Gly Trp Tyr Gln His Leu Pro Gly Met Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Lys Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu 85 90 95 Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 2292 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC variable region <400> 2292 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2293 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC variable region <400> 2293 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2294 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC variable region <400> 2294 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2295 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC variable region <400> 2295 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Gly Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Phe Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2296 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC variable region <400> 2296 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2297 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC variable region <400> 2297 Glu Leu Thr Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Pro 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 2298 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC variable region <400> 2298 Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2299 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC variable region <400> 2299 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Thr Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Asn Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2300 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC variable region <400> 2300 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Ile Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2301 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.281 LC variable region <400> 2301 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2302 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.281 HC variable region <400> 2302 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Ile Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2303 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC variable region <400> 2303 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Asn Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2304 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC variable region <400> 2304 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Ile Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2305 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC variable region <400> 2305 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Pro 85 90 95 Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2306 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC variable region <400> 2306 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 2307 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC variable region <400> 2307 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2308 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC variable region <400> 2308 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg His Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly His Val Asp Ile Pro Tyr Gly Met Asp Val Trp Gly Gln Gly 100 105 110 Thr Thr Val Thr Val Ser Ser 115 <210> 2309 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC variable region <400> 2309 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2310 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC variable region <400> 2310 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp 100 105 110 Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2311 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC variable region <400> 2311 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2312 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC variable region <400> 2312 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp 100 105 110 Pro Trp Gly Gln Gly Thr Leu Val Thr Val Pro Ser 115 120 <210> 2313 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC variable region <400> 2313 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2314 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC variable region <400> 2314 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2315 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC variable region <400> 2315 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2316 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC variable region <400> 2316 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Asn Leu Gly Tyr Cys Thr Asn Gly Val Cys Ala Pro Ser 100 105 110 Gly Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2317 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC variable region <400> 2317 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2318 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC variable region <400> 2318 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asn Leu Arg Tyr Phe Asp Trp Leu Leu Gly Asp Asp Ala Phe 100 105 110 Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 2319 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC variable region <400> 2319 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2320 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC variable region <400> 2320 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2321 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 291 LC CDR1 <400> 2321 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2322 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 291 LC CDR2 <400> 2322 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2323 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 291 LC CDR3 <400> 2323 Ala Ser Trp Asp Asp Arg Leu Ser Ala Leu Val 1 5 10 <210> 2324 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 291 HC CDR1 <400> 2324 Gly Tyr Tyr Trp Ser 1 5 <210> 2325 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 291 HC CDR2 <400> 2325 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2326 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 291 HC CDR3 <400> 2326 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2327 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 292 LC CDR1 <400> 2327 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2328 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 292 LC CDR2 <400> 2328 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2329 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 292 LC CDR3 <400> 2329 Gly Thr Trp Asp Ser Ser Leu Ser Gly Trp Val 1 5 10 <210> 2330 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 292 HC CDR1 <400> 2330 Ser Tyr Tyr Met His 1 5 <210> 2331 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 292 HC CDR2 <400> 2331 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2332 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 292 HC CDR3 <400> 2332 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2333 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 293 LC CDR1 <400> 2333 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2334 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 293 LC CDR2 <400> 2334 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2335 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 293 LC CDR3 <400> 2335 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 2336 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 293 HC CDR1 <400> 2336 Ser Tyr Ala Met Ser 1 5 <210> 2337 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 293 HC CDR2 <400> 2337 Ala Ile Ser Gly Ser Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2338 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 293 HC CDR3 <400> 2338 Val Arg Tyr Tyr Asp Phe Trp Ser Gly Trp Asp Val Met Asp Val 1 5 10 15 <210> 2339 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 294 LC CDR1 <400> 2339 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2340 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 294 LC CDR2 <400> 2340 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2341 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 294 LC CDR3 <400> 2341 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2342 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 294 HC CDR1 <400> 2342 Ser Tyr Tyr Met His 1 5 <210> 2343 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 294 HC CDR2 <400> 2343 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2344 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 294 HC CDR3 <400> 2344 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2345 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 295 LC CDR1 <400> 2345 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2346 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 295 LC CDR2 <400> 2346 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2347 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 295 LC CDR3 <400> 2347 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 2348 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 295 HC CDR1 <400> 2348 Arg Tyr Ala Met Ser 1 5 <210> 2349 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 295 HC CDR2 <400> 2349 Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2350 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 295 HC CDR3 <400> 2350 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 2351 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 296 LC CDR1 <400> 2351 Thr Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2352 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 296 LC CDR2 <400> 2352 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2353 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 296 LC CDR3 <400> 2353 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2354 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 296 HC CDR1 <400> 2354 Ser Tyr Tyr Met His 1 5 <210> 2355 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 296 HC CDR2 <400> 2355 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2356 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 296 HC CDR3 <400> 2356 Gly Gly Arg His Ser Leu Asp Ala 1 5 <210> 2357 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 297 LC CDR1 <400> 2357 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2358 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 297 LC CDR2 <400> 2358 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2359 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 297 LC CDR3 <400> 2359 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2360 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 297 HC CDR1 <400> 2360 Arg Lys Val Ile Ala 1 5 <210> 2361 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 297 HC CDR2 <400> 2361 Gly His Ala Pro Phe Val Arg Lys Pro Thr Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2362 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 297 HC CDR3 <400> 2362 Lys Ala Val Thr Thr Tyr Ser Gly Phe Asp Asn 1 5 10 <210> 2363 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 298 LC CDR1 <400> 2363 Arg Ala Ser Gln Gly Ile Ser Asn Ser Leu Ala 1 5 10 <210> 2364 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 298 LC CDR2 <400> 2364 Ala Ala Ser Arg Leu Glu Ser 1 5 <210> 2365 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 298 LC CDR3 <400> 2365 Gln Gln Tyr Tyr Ser Thr Pro Tyr Thr 1 5 <210> 2366 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 298 HC CDR1 <400> 2366 Asn Ala Trp Met Thr 1 5 <210> 2367 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 298 HC CDR2 <400> 2367 Arg Ile Lys Thr Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro 1 5 10 15 Val Lys Gly <210> 2368 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> No. 298 HC CDR3 <400> 2368 His Ser Arg Pro Asp Tyr 1 5 <210> 2369 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 299 LC CDR1 <400> 2369 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2370 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 299 LC CDR2 <400> 2370 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2371 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 299 LC CDR3 <400> 2371 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2372 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 299 HC CDR1 <400> 2372 Arg Lys Val Ile Ala 1 5 <210> 2373 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 299 HC CDR2 <400> 2373 Gly His Ala Pro Phe Val Arg Lys Pro Thr Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2374 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 299 HC CDR3 <400> 2374 Lys Ala Val Thr Thr Tyr Ser Gly Phe Asp Thr 1 5 10 <210> 2375 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 300 LC CDR1 <400> 2375 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 2376 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 300 LC CDR2 <400> 2376 Trp Ala Ser Thr Arg Glu Ser 1 5 <210> 2377 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 300 LC CDR3 <400> 2377 Leu Gln Tyr Phe Thr Ile Pro Trp Thr 1 5 <210> 2378 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 300 HC CDR1 <400> 2378 Asn Ala Trp Met Ser 1 5 <210> 2379 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 300 HC CDR2 <400> 2379 Arg Ile Lys Thr Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro 1 5 10 15 Val Lys Gly <210> 2380 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> No. 300 HC CDR3 <400> 2380 Phe Ser Thr Pro Asp Tyr 1 5 <210> 2381 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 301 LC CDR1 <400> 2381 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2382 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 301 LC CDR2 <400> 2382 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 2383 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 301 LC CDR3 <400> 2383 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val 1 5 10 <210> 2384 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 301 HC CDR1 <400> 2384 Arg Tyr Ala Ile Ser 1 5 <210> 2385 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 301 HC CDR2 <400> 2385 Gly Ile Ile Pro Ile Phe Gly Lys Val Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 2386 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 301 HC CDR3 <400> 2386 Gly Gly Ser Thr Trp Tyr Gly Gly Asn Trp Phe Asp Pro 1 5 10 <210> 2387 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 302 LC CDR1 <400> 2387 Ser Gly Asp Val Leu Ala Lys Lys Tyr Ala Arg 1 5 10 <210> 2388 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 302 LC CDR2 <400> 2388 Lys Asp Ser Glu Arg Pro Ser 1 5 <210> 2389 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 302 LC CDR3 <400> 2389 Tyr Ser Ala Ala Asp Asn Asn Gly Val 1 5 <210> 2390 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 302 HC CDR1 <400> 2390 Ser Asp Ala Met His 1 5 <210> 2391 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 302 HC CDR2 <400> 2391 Val Ile Ser Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2392 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 302 HC CDR3 <400> 2392 Glu Ala Thr Tyr Asp Ser Ser Gly Arg Pro Thr Gly Asp Tyr Gly Met 1 5 10 15 Asp Val <210> 2393 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 303 LC CDR1 <400> 2393 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2394 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 303 LC CDR2 <400> 2394 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2395 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 303 LC CDR3 <400> 2395 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 2396 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 303 HC CDR1 <400> 2396 Gly Tyr Tyr Trp Ser 1 5 <210> 2397 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 303 HC CDR2 <400> 2397 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2398 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 303 HC CDR3 <400> 2398 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2399 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 304 LC CDR1 <400> 2399 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2400 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 304 LC CDR2 <400> 2400 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 2401 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 304 LC CDR3 <400> 2401 Ser Ser Tyr Thr Ser Ser Ser Thr Ser His Val Val 1 5 10 <210> 2402 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 304 HC CDR1 <400> 2402 Ser Tyr Ala Met Asn 1 5 <210> 2403 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 304 HC CDR2 <400> 2403 Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2404 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 304 HC CDR3 <400> 2404 Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser Glu Tyr 1 5 10 15 Tyr Phe Asp Tyr 20 <210> 2405 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 305 LC CDR1 <400> 2405 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2406 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 305 LC CDR2 <400> 2406 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 2407 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 305 LC CDR3 <400> 2407 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val 1 5 10 <210> 2408 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> No. 305 HC CDR1 <400> 2408 Arg Gly Asp Tyr Trp Gly 1 5 <210> 2409 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 305 HC CDR2 <400> 2409 Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2410 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 305 HC CDR3 <400> 2410 His Gly Thr Ser Gly Tyr Tyr Tyr Pro Asn Trp Phe Asp Pro 1 5 10 <210> 2411 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 306 LC CDR1 <400> 2411 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2412 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 306 LC CDR2 <400> 2412 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2413 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 306 LC CDR3 <400> 2413 Ala Ala Trp Asp Asp Ser Leu Asn Ala Ser Leu 1 5 10 <210> 2414 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 306 HC CDR1 <400> 2414 Gly Tyr Tyr Trp Ser 1 5 <210> 2415 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 306 HC CDR2 <400> 2415 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2416 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 306 HC CDR3 <400> 2416 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2417 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 307 LC CDR1 <400> 2417 Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2418 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 307 LC CDR2 <400> 2418 Thr Asp Asn Arg Arg Pro Ser 1 5 <210> 2419 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 307 LC CDR3 <400> 2419 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 2420 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 307 HC CDR1 <400> 2420 Gly Tyr Tyr Trp Ser 1 5 <210> 2421 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 307 HC CDR2 <400> 2421 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2422 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 307 HC CDR3 <400> 2422 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2423 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 308 LC CDR1 <400> 2423 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2424 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 308 LC CDR2 <400> 2424 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2425 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 308 LC CDR3 <400> 2425 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 2426 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 308 HC CDR1 <400> 2426 Gly Tyr Tyr Trp Ser 1 5 <210> 2427 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 308 HC CDR2 <400> 2427 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2428 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 308 HC CDR3 <400> 2428 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2429 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 309 LC CDR1 <400> 2429 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2430 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 309 LC CDR2 <400> 2430 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2431 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 309 LC CDR3 <400> 2431 Ala Ala Arg Asp Asp Ser Leu Asn Gly Ala Val 1 5 10 <210> 2432 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 309 HC CDR1 <400> 2432 Gly Tyr Tyr Trp Ser 1 5 <210> 2433 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 309 HC CDR2 <400> 2433 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2434 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 309 HC CDR3 <400> 2434 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2435 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 310 LC CDR1 <400> 2435 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2436 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 310 LC CDR2 <400> 2436 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2437 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 310 LC CDR3 <400> 2437 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Pro 1 5 10 <210> 2438 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 310 HC CDR1 <400> 2438 Thr Ser Gly Val Gly Val Gly 1 5 <210> 2439 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 310 HC CDR2 <400> 2439 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 2440 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 310 HC CDR3 <400> 2440 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 2441 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 311 LC CDR1 <400> 2441 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2442 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 311 LC CDR2 <400> 2442 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2443 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 311 LC CDR3 <400> 2443 Gln Glu Tyr Gly Ser Ser Pro Arg Arg Val Thr 1 5 10 <210> 2444 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 311 HC CDR1 <400> 2444 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2445 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 311 HC CDR2 <400> 2445 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2446 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 311 HC CDR3 <400> 2446 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2447 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 312 LC CDR1 <400> 2447 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2448 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 312 LC CDR2 <400> 2448 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 2449 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 312 LC CDR3 <400> 2449 Gln Gln Tyr Tyr Gln Val Pro Leu Thr 1 5 <210> 2450 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 312 HC CDR1 <400> 2450 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2451 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 312 HC CDR2 <400> 2451 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2452 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 312 HC CDR3 <400> 2452 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2453 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 313 LC CDR1 <400> 2453 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2454 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 313 LC CDR2 <400> 2454 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2455 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 313 LC CDR3 <400> 2455 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 2456 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 313 HC CDR1 <400> 2456 Asp Tyr Gly Met His 1 5 <210> 2457 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 313 HC CDR2 <400> 2457 Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2458 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 313 HC CDR3 <400> 2458 Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr Tyr Ala 1 5 10 15 Met Asp Val <210> 2459 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 314 LC CDR1 <400> 2459 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2460 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 314 LC CDR2 <400> 2460 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 2461 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 314 LC CDR3 <400> 2461 Ser Ser Tyr Thr Ser Ser Ser Thr Tyr Val 1 5 10 <210> 2462 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 314 HC CDR1 <400> 2462 Glu Leu Ser Ile His 1 5 <210> 2463 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 314 HC CDR2 <400> 2463 Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2464 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 314 HC CDR3 <400> 2464 Ser Pro Ala Val Thr Thr Ala Gly Trp Phe Asp Pro 1 5 10 <210> 2465 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 315 LC CDR1 <400> 2465 Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn Thr Val Asn 1 5 10 <210> 2466 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 315 LC CDR2 <400> 2466 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2467 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 315 LC CDR3 <400> 2467 Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Leu 1 5 10 <210> 2468 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 315 HC CDR1 <400> 2468 Gly Tyr Tyr Trp Ser 1 5 <210> 2469 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 315 HC CDR2 <400> 2469 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2470 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 315 HC CDR3 <400> 2470 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2471 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 316 LC CDR1 <400> 2471 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2472 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 316 LC CDR2 <400> 2472 Asp Val Gly Lys Arg Pro Ser 1 5 <210> 2473 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 316 LC CDR3 <400> 2473 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 2474 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 316 HC CDR1 <400> 2474 Phe Tyr Ala Ile Ser 1 5 <210> 2475 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 316 HC CDR2 <400> 2475 Gly Ile Ile Pro Leu Phe Gly Thr Ala Lys Tyr Ala Gln Arg Phe Gln 1 5 10 15 Asp <210> 2476 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 316 HC CDR3 <400> 2476 Gly Gly Trp Ile Tyr Arg Gly Asn Trp Phe Asp Pro 1 5 10 <210> 2477 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 317 LC CDR1 <400> 2477 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2478 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 317 LC CDR2 <400> 2478 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2479 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 317 LC CDR3 <400> 2479 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Val 1 5 10 <210> 2480 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 317 HC CDR1 <400> 2480 Asn Tyr Gly Ile Ser 1 5 <210> 2481 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 317 HC CDR2 <400> 2481 Gly Ile Ser Ser His Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu Gln 1 5 10 15 Gly <210> 2482 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 317 HC CDR3 <400> 2482 Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Arg Phe 1 5 10 15 Ala Phe Asp Ile 20 <210> 2483 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 318 LC CDR1 <400> 2483 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2484 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 318 LC CDR2 <400> 2484 Glu Val Ser Lys Arg Pro Ser 1 5 <210> 2485 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 318 LC CDR3 <400> 2485 Ser Ser Tyr Ala Gly Ser Asn Tyr Val Val 1 5 10 <210> 2486 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 318 HC CDR1 <400> 2486 Ser Tyr Ala Met Ser 1 5 <210> 2487 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 318 HC CDR2 <400> 2487 Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2488 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 318 HC CDR3 <400> 2488 Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser Glu Tyr 1 5 10 15 Tyr Phe Asp Tyr 20 <210> 2489 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 319 LC CDR1 <400> 2489 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2490 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 319 LC CDR2 <400> 2490 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 2491 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 319 LC CDR3 <400> 2491 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Gly Val 1 5 10 <210> 2492 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 319 HC CDR1 <400> 2492 Ser Tyr Ala Met Ser 1 5 <210> 2493 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 319 HC CDR2 <400> 2493 Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2494 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 319 HC CDR3 <400> 2494 Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser Glu Tyr 1 5 10 15 Tyr Phe Asp Tyr 20 <210> 2495 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 320 LC CDR1 <400> 2495 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2496 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 320 LC CDR2 <400> 2496 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2497 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 320 LC CDR3 <400> 2497 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2498 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 320 HC CDR1 <400> 2498 Gly Tyr Tyr Met His 1 5 <210> 2499 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 320 HC CDR2 <400> 2499 Val Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2500 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 320 HC CDR3 <400> 2500 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2501 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 321 LC CDR1 <400> 2501 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2502 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 321 LC CDR2 <400> 2502 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2503 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 321 LC CDR3 <400> 2503 Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val 1 5 10 <210> 2504 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 321 HC CDR1 <400> 2504 Ser Tyr Trp Ile Val 1 5 <210> 2505 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 321 HC CDR2 <400> 2505 Thr Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 2506 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 321 HC CDR3 <400> 2506 Gly Pro Asn Ile Tyr Asn Trp Phe Asp Ser 1 5 10 <210> 2507 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 322 LC CDR1 <400> 2507 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2508 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 322 LC CDR2 <400> 2508 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 2509 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 322 LC CDR3 <400> 2509 Gln Gln Ser Tyr Ser Thr Pro Leu Thr 1 5 <210> 2510 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 322 HC CDR1 <400> 2510 Ser Asn Tyr Met Thr 1 5 <210> 2511 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 322 HC CDR2 <400> 2511 Ile Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 2512 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 322 HC CDR3 <400> 2512 Asp Leu Pro Leu Thr Gly Thr Thr Leu Asp Tyr 1 5 10 <210> 2513 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 323 LC CDR1 <400> 2513 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 2514 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 323 LC CDR2 <400> 2514 Asp Asp Ser Asp Arg Pro Ser 1 5 <210> 2515 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 323 LC CDR3 <400> 2515 Gln Val Trp Asp Ser Ser Ser Asp His Val Val 1 5 10 <210> 2516 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 323 HC CDR1 <400> 2516 Asp Tyr Gly Met His 1 5 <210> 2517 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 323 HC CDR2 <400> 2517 Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2518 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 323 HC CDR3 <400> 2518 Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr Tyr Ala 1 5 10 15 Met Asp Val <210> 2519 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 324 LC CDR1 <400> 2519 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2520 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 324 LC CDR2 <400> 2520 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2521 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 324 LC CDR3 <400> 2521 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Val 1 5 10 <210> 2522 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 324 HC CDR1 <400> 2522 Asn Tyr Pro Leu Thr 1 5 <210> 2523 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 324 HC CDR2 <400> 2523 Gly Ile Ile Pro Ile Ile Gly Ala Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2524 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 324 HC CDR3 <400> 2524 Gly Arg Gly Tyr Ser Gly Tyr Gly Ala Ala Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 2525 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 325 LC CDR1 <400> 2525 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2526 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 325 LC CDR2 <400> 2526 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2527 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 325 LC CDR3 <400> 2527 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Trp Val 1 5 10 <210> 2528 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 325 HC CDR1 <400> 2528 Arg Tyr Ala Ile Ser 1 5 <210> 2529 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 325 HC CDR2 <400> 2529 Gly Ile Ile Pro Ile Phe Gly Thr Gly Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2530 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 325 HC CDR3 <400> 2530 Ser Leu Tyr Tyr Tyr Asp Arg Ser Gly Tyr Pro Ile Ser Glu Asp Tyr 1 5 10 15 Phe Asp Tyr <210> 2531 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 326 LC CDR1 <400> 2531 Arg Ala Ser Gln Ser Val Gly Ser Ser Tyr Leu Ala 1 5 10 <210> 2532 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 326 LC CDR2 <400> 2532 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 2533 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 326 LC CDR3 <400> 2533 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 2534 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 326 HC CDR1 <400> 2534 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2535 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 326 HC CDR2 <400> 2535 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2536 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 326 HC CDR3 <400> 2536 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2537 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 327 LC CDR1 <400> 2537 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2538 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 327 LC CDR2 <400> 2538 Thr Asn Asn Arg Arg Pro Ser 1 5 <210> 2539 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 327 LC CDR3 <400> 2539 Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val 1 5 10 <210> 2540 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 327 HC CDR1 <400> 2540 Ser His Trp Ile Ala 1 5 <210> 2541 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 327 HC CDR2 <400> 2541 Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 2542 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 327 HC CDR3 <400> 2542 Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser 1 5 10 <210> 2543 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 328 LC CDR1 <400> 2543 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 2544 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 328 LC CDR2 <400> 2544 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 2545 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 328 LC CDR3 <400> 2545 Gln Val Trp Asp Ser Ser Ser Asp His Trp Val 1 5 10 <210> 2546 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 328 HC CDR1 <400> 2546 Asp Tyr Ala Met Ser 1 5 <210> 2547 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 328 HC CDR2 <400> 2547 Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Asn Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2548 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 328 HC CDR3 <400> 2548 Val Tyr Cys Gly Asp Asp Cys Tyr Pro Val Val Gly Thr Pro Gly Asp 1 5 10 15 Ala Phe Asp Ile 20 <210> 2549 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 329 LC CDR1 <400> 2549 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2550 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 329 LC CDR2 <400> 2550 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2551 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 329 LC CDR3 <400> 2551 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Trp Val 1 5 10 <210> 2552 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 329 HC CDR1 <400> 2552 Asp Tyr Gly Met His 1 5 <210> 2553 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 329 HC CDR2 <400> 2553 Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2554 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 329 HC CDR3 <400> 2554 Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr Tyr Ala 1 5 10 15 Met Asp Val <210> 2555 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 330 LC CDR1 <400> 2555 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2556 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 330 LC CDR2 <400> 2556 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2557 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 330 LC CDR3 <400> 2557 Gln Gln Tyr Gly Ser Ser Pro Gln Thr 1 5 <210> 2558 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 330 HC CDR1 <400> 2558 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2559 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 330 HC CDR2 <400> 2559 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2560 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 330 HC CDR3 <400> 2560 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2561 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 331 LC CDR1 <400> 2561 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2562 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 331 LC CDR2 <400> 2562 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2563 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 331 LC CDR3 <400> 2563 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 2564 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 331 HC CDR1 <400> 2564 Gly Tyr Tyr Trp Ser 1 5 <210> 2565 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 331 HC CDR2 <400> 2565 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2566 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 331 HC CDR3 <400> 2566 Gly Arg Tyr Tyr Ser Ser Trp Tyr Gly Pro Arg Thr Trp Phe Asp Pro 1 5 10 15 <210> 2567 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 332 LC CDR1 <400> 2567 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 2568 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 332 LC CDR2 <400> 2568 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 2569 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 332 LC CDR3 <400> 2569 Gln Ser Tyr Asp Ser Ser Asn Trp Val 1 5 <210> 2570 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 332 HC CDR1 <400> 2570 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2571 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 332 HC CDR2 <400> 2571 Asn Phe Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2572 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 332 HC CDR3 <400> 2572 Gln Glu Trp Leu Arg Gly Gly Phe Asp Asp 1 5 10 <210> 2573 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 333 LC CDR1 <400> 2573 Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn Tyr Val His 1 5 10 <210> 2574 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 333 LC CDR2 <400> 2574 Ser Asn Asp Gln Arg Pro Ser 1 5 <210> 2575 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 333 LC CDR3 <400> 2575 Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 1 5 10 <210> 2576 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 333 HC CDR1 <400> 2576 Ser Tyr Ala Ile Ser 1 5 <210> 2577 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 333 HC CDR2 <400> 2577 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Arg Phe Gln 1 5 10 15 Gly <210> 2578 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 333 HC CDR3 <400> 2578 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 2579 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 334 LC CDR1 <400> 2579 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2580 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 334 LC CDR2 <400> 2580 Asp Ala Ser Ser Arg Ala Thr 1 5 <210> 2581 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 334 LC CDR3 <400> 2581 Gln Gln Tyr Gly Ser Ser Pro Ser Ile Thr 1 5 10 <210> 2582 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 334 HC CDR1 <400> 2582 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2583 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 334 HC CDR2 <400> 2583 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2584 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 334 HC CDR3 <400> 2584 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2585 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 335 LC CDR1 <400> 2585 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2586 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 335 LC CDR2 <400> 2586 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2587 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 335 LC CDR3 <400> 2587 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Pro Val 1 5 10 <210> 2588 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 335 HC CDR1 <400> 2588 Ser Tyr Asp Ile Ser 1 5 <210> 2589 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 335 HC CDR2 <400> 2589 Gly Ile Ile Pro Ile Leu Gly Ile Pro Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2590 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 335 HC CDR3 <400> 2590 Ser Arg Gly Tyr Ser Gly Tyr Gly Ala Asn Trp Tyr Phe Asp Leu 1 5 10 15 <210> 2591 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 336 LC CDR1 <400> 2591 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 2592 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 336 LC CDR2 <400> 2592 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 2593 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 336 LC CDR3 <400> 2593 Gln Ser Tyr Asp Ser Ser Asn Trp Val 1 5 <210> 2594 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 336 HC CDR1 <400> 2594 Arg Tyr Gly Ile Ser 1 5 <210> 2595 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 336 HC CDR2 <400> 2595 Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu Gln 1 5 10 15 Gly <210> 2596 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 336 HC CDR3 <400> 2596 Val Leu Gly Ile Ala Val Ala Gly Thr Pro Ile 1 5 10 <210> 2597 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 337 LC CDR1 <400> 2597 Arg Ala Ser Gln Ser Val Arg Ser Asp Ile Ala 1 5 10 <210> 2598 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 337 LC CDR2 <400> 2598 Asp Thr Ser Thr Arg Ala Thr 1 5 <210> 2599 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 337 LC CDR3 <400> 2599 Gln Gln Tyr Tyr Thr Thr Pro Phe Thr 1 5 <210> 2600 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 337 HC CDR1 <400> 2600 Asp Tyr Tyr Ile Gln 1 5 <210> 2601 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 337 HC CDR2 <400> 2601 Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe Gln 1 5 10 15 Gly <210> 2602 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 337 HC CDR3 <400> 2602 Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro 1 5 10 <210> 2603 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 338 LC CDR1 <400> 2603 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2604 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 338 LC CDR2 <400> 2604 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2605 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 338 LC CDR3 <400> 2605 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Leu Trp Val 1 5 10 <210> 2606 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 338 HC CDR1 <400> 2606 Ser Asn Tyr Met Ser 1 5 <210> 2607 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 338 HC CDR2 <400> 2607 Val Ile Tyr Pro Gly Gly Ser Thr Phe Phe Ala Asp Ser Val Gln Gly 1 5 10 15 <210> 2608 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 338 HC CDR3 <400> 2608 Ser Tyr Asp Phe Leu Thr Asp Tyr Thr Asp Ala Phe Asp Ile 1 5 10 <210> 2609 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 339 LC CDR1 <400> 2609 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2610 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 339 LC CDR2 <400> 2610 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 2611 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 339 LC CDR3 <400> 2611 Ser Ser Tyr Thr Ser Ser Ser Pro Trp Val 1 5 10 <210> 2612 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 339 HC CDR1 <400> 2612 Ser Tyr Ala Met Ser 1 5 <210> 2613 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 339 HC CDR2 <400> 2613 Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2614 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 339 HC CDR3 <400> 2614 Gly Val Val Thr Ala Asp Trp Tyr Phe Asp Leu 1 5 10 <210> 2615 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 340 LC CDR1 <400> 2615 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2616 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 340 LC CDR2 <400> 2616 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2617 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 340 LC CDR3 <400> 2617 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Pro Trp Val 1 5 10 <210> 2618 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 340 HC CDR1 <400> 2618 Arg Tyr Ala Ile Asn 1 5 <210> 2619 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 340 HC CDR2 <400> 2619 Gly Ile Ile Pro Leu Leu Gly Thr Ala Asp Tyr Pro Gln Lys Phe Gln 1 5 10 15 Gly <210> 2620 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 340 HC CDR3 <400> 2620 Thr Leu Tyr Tyr Tyr Asp Arg Ser Gly Asn Ala Arg Thr Asp Asp Tyr 1 5 10 15 Phe Asp His <210> 2621 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 341 LC CDR1 <400> 2621 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2622 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 341 LC CDR2 <400> 2622 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2623 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 341 LC CDR3 <400> 2623 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 2624 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 341 HC CDR1 <400> 2624 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2625 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 341 HC CDR2 <400> 2625 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2626 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 341 HC CDR3 <400> 2626 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2627 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 342 LC CDR1 <400> 2627 Arg Ala Ser Gln Ser Val Asn Ser Asn Leu Ala 1 5 10 <210> 2628 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 342 LC CDR2 <400> 2628 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 2629 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 342 LC CDR3 <400> 2629 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 2630 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 342 HC CDR1 <400> 2630 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2631 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 342 HC CDR2 <400> 2631 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2632 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 342 HC CDR3 <400> 2632 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2633 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 343 LC CDR1 <400> 2633 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2634 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 343 LC CDR2 <400> 2634 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 2635 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 343 LC CDR3 <400> 2635 Gln Gln Ser Tyr Ser Thr Pro Leu Thr 1 5 <210> 2636 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 343 HC CDR1 <400> 2636 Ser Asn Tyr Met Ser 1 5 <210> 2637 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 343 HC CDR2 <400> 2637 Val Ile Tyr Pro Gly Gly Ser Thr Phe Phe Ala Asp Ser Val Gln Gly 1 5 10 15 <210> 2638 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 343 HC CDR3 <400> 2638 Ser Tyr Asp Phe Leu Thr Asp Tyr Thr Asp Ala Phe Asp Ile 1 5 10 <210> 2639 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 344 LC CDR1 <400> 2639 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2640 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 344 LC CDR2 <400> 2640 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2641 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 344 LC CDR3 <400> 2641 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val 1 5 10 <210> 2642 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 344 HC CDR1 <400> 2642 Asp Tyr Ala Met His 1 5 <210> 2643 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 344 HC CDR2 <400> 2643 Gly Ile Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2644 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 344 HC CDR3 <400> 2644 Glu Glu Leu Gly Pro Tyr Ser Asn Arg Trp Tyr Ser Ser Ser Asp Gly 1 5 10 15 Met Asp Val <210> 2645 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 345 LC CDR1 <400> 2645 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2646 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 345 LC CDR2 <400> 2646 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 2647 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 345 LC CDR3 <400> 2647 Gln Gln Ser Tyr Ser Thr Pro Leu Thr 1 5 <210> 2648 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 345 HC CDR1 <400> 2648 Ser Ser Ala Ile Asn 1 5 <210> 2649 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 345 HC CDR2 <400> 2649 Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2650 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 345 HC CDR3 <400> 2650 Asp His Ile Val Ser Pro Leu Tyr Gly Met Asp Val 1 5 10 <210> 2651 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 346 LC CDR1 <400> 2651 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2652 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 346 LC CDR2 <400> 2652 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2653 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 346 LC CDR3 <400> 2653 Gln Ser Tyr Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2654 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 346 HC CDR1 <400> 2654 Ser Asn Tyr Met Ser 1 5 <210> 2655 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 346 HC CDR2 <400> 2655 Val Ile Tyr Pro Gly Gly Ser Thr Phe Phe Ala Asp Ser Val Gln Gly 1 5 10 15 <210> 2656 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 346 HC CDR3 <400> 2656 Ser Tyr Asp Phe Leu Thr Asp Tyr Thr Asp Ala Phe Asp Ile 1 5 10 <210> 2657 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 347 LC CDR1 <400> 2657 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 1 5 10 <210> 2658 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 347 LC CDR2 <400> 2658 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 2659 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 347 LC CDR3 <400> 2659 Gln Gln Tyr Tyr Ser Thr Pro Ile Thr 1 5 <210> 2660 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 347 HC CDR1 <400> 2660 Asp Tyr Tyr Ile Gln 1 5 <210> 2661 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 347 HC CDR2 <400> 2661 Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe Gln 1 5 10 15 Gly <210> 2662 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 347 HC CDR3 <400> 2662 Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro 1 5 10 <210> 2663 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 348 LC CDR1 <400> 2663 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Ser His Val Ser 1 5 10 <210> 2664 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 348 LC CDR2 <400> 2664 Glu Val Ser Asp Arg Pro Ser 1 5 <210> 2665 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 348 LC CDR3 <400> 2665 Asn Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 2666 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 348 HC CDR1 <400> 2666 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2667 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 348 HC CDR2 <400> 2667 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2668 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 348 HC CDR3 <400> 2668 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2669 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 349 LC CDR1 <400> 2669 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 2670 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 349 LC CDR2 <400> 2670 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 2671 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 349 LC CDR3 <400> 2671 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 2672 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 349 HC CDR1 <400> 2672 Gly Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2673 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 349 HC CDR2 <400> 2673 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2674 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 349 HC CDR3 <400> 2674 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2675 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 350 LC CDR1 <400> 2675 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2676 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 350 LC CDR2 <400> 2676 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2677 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 350 LC CDR3 <400> 2677 Gln Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 1 5 10 <210> 2678 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 350 HC CDR1 <400> 2678 Ser Tyr Ala Ile Ile 1 5 <210> 2679 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 350 HC CDR2 <400> 2679 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2680 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 350 HC CDR3 <400> 2680 Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr 1 5 10 <210> 2681 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 351 LC CDR1 <400> 2681 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp 1 5 10 <210> 2682 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 351 LC CDR2 <400> 2682 Asp Asp Ser Asp Arg Pro Ser 1 5 <210> 2683 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 351 LC CDR3 <400> 2683 Gln Val Trp Asp Ser Ser Ser Asp Arg Val Val 1 5 10 <210> 2684 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 351 HC CDR1 <400> 2684 Asp Tyr Ala Met His 1 5 <210> 2685 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 351 HC CDR2 <400> 2685 Gly Thr Thr Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2686 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 351 HC CDR3 <400> 2686 Asp Ile Gly Ser Gly Asp Arg Pro Asp Ala Phe His Leu 1 5 10 <210> 2687 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 352 LC CDR1 <400> 2687 Ser Gly Ser Ser Ser Asn Ile Glu Asn Asn Tyr Val Ser 1 5 10 <210> 2688 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 352 LC CDR2 <400> 2688 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2689 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 352 LC CDR3 <400> 2689 Gly Thr Trp Asp Asn Ser Leu Ser Ala Trp Val 1 5 10 <210> 2690 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 352 HC CDR1 <400> 2690 Ser Tyr Tyr Met His 1 5 <210> 2691 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 352 HC CDR2 <400> 2691 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2692 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 352 HC CDR3 <400> 2692 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2693 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 353 LC CDR1 <400> 2693 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 2694 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 353 LC CDR2 <400> 2694 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 2695 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 353 LC CDR3 <400> 2695 Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 1 5 <210> 2696 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 353 HC CDR1 <400> 2696 Ser Ser Pro Met His 1 5 <210> 2697 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 353 HC CDR2 <400> 2697 Val Ile Ser Tyr Gly Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2698 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 353 HC CDR3 <400> 2698 Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2699 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 354 LC CDR1 <400> 2699 Thr Gly Asn Arg Ser Asp Ile Gly Gly Tyr Asn Ser Leu Ser 1 5 10 <210> 2700 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 354 LC CDR2 <400> 2700 Asp Val Asn Asn Arg Pro Ser 1 5 <210> 2701 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 354 LC CDR3 <400> 2701 Asn Ser Tyr Thr Ser Lys Asn Thr Trp Val 1 5 10 <210> 2702 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 354 HC CDR1 <400> 2702 Ser Ser Pro Met His 1 5 <210> 2703 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 354 HC CDR2 <400> 2703 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2704 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 354 HC CDR3 <400> 2704 Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2705 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 355 LC CDR1 <400> 2705 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 2706 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 355 LC CDR2 <400> 2706 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 2707 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 355 LC CDR3 <400> 2707 Gln Gln Tyr Gly Ser Ser Pro Phe Thr 1 5 <210> 2708 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 355 HC CDR1 <400> 2708 Ser Ser Pro Met His 1 5 <210> 2709 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 355 HC CDR2 <400> 2709 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2710 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 355 HC CDR3 <400> 2710 Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2711 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 356 LC CDR1 <400> 2711 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2712 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 356 LC CDR2 <400> 2712 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 2713 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 356 LC CDR3 <400> 2713 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 2714 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 356 HC CDR1 <400> 2714 Ser Ser Pro Met His 1 5 <210> 2715 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 356 HC CDR2 <400> 2715 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2716 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 356 HC CDR3 <400> 2716 Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2717 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 357 LC CDR1 <400> 2717 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 2718 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 357 LC CDR2 <400> 2718 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 2719 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 357 LC CDR3 <400> 2719 Gln Gln Tyr Gly Ser Ser Pro Ala Leu Thr 1 5 10 <210> 2720 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 357 HC CDR1 <400> 2720 Ser Ser Pro Met His 1 5 <210> 2721 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 357 HC CDR2 <400> 2721 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2722 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 357 HC CDR3 <400> 2722 Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2723 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 358 LC CDR1 <400> 2723 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2724 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 358 LC CDR2 <400> 2724 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2725 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 358 LC CDR3 <400> 2725 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2726 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 358 HC CDR1 <400> 2726 Arg Lys Val Ile Ala 1 5 <210> 2727 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 358 HC CDR2 <400> 2727 Gly His Ala Pro Phe Val Arg Lys Pro Thr Tyr Ala Arg Lys Phe Gln 1 5 10 15 Gly <210> 2728 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 358 HC CDR3 <400> 2728 Lys Ala Val Thr Thr Tyr Ser Gly Phe Asp Asn 1 5 10 <210> 2729 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 359 LC CDR1 <400> 2729 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Asn Val Ser 1 5 10 <210> 2730 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 359 LC CDR2 <400> 2730 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 2731 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 359 LC CDR3 <400> 2731 Ser Ser Tyr Thr Ser Ser Ser Pro Trp Val 1 5 10 <210> 2732 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 359 HC CDR1 <400> 2732 Ser Tyr Ala Ile Ser 1 5 <210> 2733 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 359 HC CDR2 <400> 2733 Gly Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2734 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 359 HC CDR3 <400> 2734 Asp Pro Thr Ser Arg Ser Thr Tyr Tyr Tyr Tyr Ser Gly Ser Tyr Tyr 1 5 10 15 Pro <210> 2735 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 360 LC CDR1 <400> 2735 Thr Gly Thr Ser Thr Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2736 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 360 LC CDR2 <400> 2736 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 2737 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 360 LC CDR3 <400> 2737 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val 1 5 10 <210> 2738 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 360 HC CDR1 <400> 2738 Asn Tyr Gly Met His 1 5 <210> 2739 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 360 HC CDR2 <400> 2739 Val Met Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2740 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 360 HC CDR3 <400> 2740 Pro Asp Asp Ser Ser Gly Tyr Tyr Pro Asp Tyr 1 5 10 <210> 2741 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 361 LC CDR1 <400> 2741 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2742 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 361 LC CDR2 <400> 2742 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 2743 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 361 LC CDR3 <400> 2743 Ser Ser Tyr Thr Ser Ser Arg Thr Trp Val 1 5 10 <210> 2744 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 361 HC CDR1 <400> 2744 Gly Tyr Ala Met His 1 5 <210> 2745 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 361 HC CDR2 <400> 2745 Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2746 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 361 HC CDR3 <400> 2746 Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val 1 5 10 <210> 2747 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 362 LC CDR1 <400> 2747 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Ala Val Asn 1 5 10 <210> 2748 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 362 LC CDR2 <400> 2748 Ser Asn Ser Tyr Arg Pro Ser 1 5 <210> 2749 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 362 LC CDR3 <400> 2749 Gln Ser Tyr Asp Ser Ala Leu Arg Gly Pro Leu 1 5 10 <210> 2750 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 362 HC CDR1 <400> 2750 Ser Tyr Gly Ile Ser 1 5 <210> 2751 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 362 HC CDR2 <400> 2751 Gly Ile Ile Pro Ile Leu Ala Thr Thr Lys Phe Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2752 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 362 HC CDR3 <400> 2752 Gly Trp Gly Leu Arg Leu Phe Gly Glu Phe Ser Val Trp Phe Asp Pro 1 5 10 15 <210> 2753 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 363 LC CDR1 <400> 2753 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2754 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 363 LC CDR2 <400> 2754 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2755 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 363 LC CDR3 <400> 2755 Gln Ser Tyr Asp Ser Ser Leu Ser Asp Val Val 1 5 10 <210> 2756 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 363 HC CDR1 <400> 2756 Ser Tyr Gly Ile Ser 1 5 <210> 2757 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 363 HC CDR2 <400> 2757 Gly Ile Ile Pro Ile Leu Ala Thr Thr Lys Phe Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2758 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 363 HC CDR3 <400> 2758 Gly Trp Gly Leu Arg Leu Phe Gly Glu Phe Ser Val Trp Phe Asp Pro 1 5 10 15 <210> 2759 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 364 LC CDR1 <400> 2759 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2760 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 364 LC CDR2 <400> 2760 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 2761 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 364 LC CDR3 <400> 2761 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 2762 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 364 HC CDR1 <400> 2762 Ser Tyr Ala Met His 1 5 <210> 2763 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 364 HC CDR2 <400> 2763 Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2764 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 364 HC CDR3 <400> 2764 Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val 1 5 10 <210> 2765 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 365 LC CDR1 <400> 2765 Ser Ser Ser Thr Gly Ala Val Thr Arg Gly His Phe Pro Asn 1 5 10 <210> 2766 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 365 LC CDR2 <400> 2766 Ser Thr Ser Asn Lys His Ser 1 5 <210> 2767 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 365 LC CDR3 <400> 2767 Leu Leu Tyr Asp Ala Gly Ala Pro Gly Trp Val 1 5 10 <210> 2768 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 365 HC CDR1 <400> 2768 Ser Tyr Pro Met His 1 5 <210> 2769 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 365 HC CDR2 <400> 2769 Val Ile Ser Tyr Asp Gly Ser Leu Lys Tyr Tyr Val Asp Ser Val Lys 1 5 10 15 Gly <210> 2770 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 365 HC CDR3 <400> 2770 Asp Ser Ser Cys Ser Gly Gly Ser Cys Phe Asp Tyr 1 5 10 <210> 2771 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 366 LC CDR1 <400> 2771 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2772 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 366 LC CDR2 <400> 2772 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2773 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 366 LC CDR3 <400> 2773 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val 1 5 10 <210> 2774 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 366 HC CDR1 <400> 2774 Ser Tyr Gly Ile Ser 1 5 <210> 2775 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 366 HC CDR2 <400> 2775 Gly Ile Ile Pro Ile Leu Ala Thr Thr Lys Phe Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2776 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 366 HC CDR3 <400> 2776 Gly Trp Gly Leu Arg Leu Phe Gly Glu Phe Ser Val Trp Phe Asp Pro 1 5 10 15 <210> 2777 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 367 LC CDR1 <400> 2777 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2778 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 367 LC CDR2 <400> 2778 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2779 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 367 LC CDR3 <400> 2779 Gly Ala Trp Asp Ser Ser Leu Ser Thr Pro Asn Trp Val 1 5 10 <210> 2780 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 367 HC CDR1 <400> 2780 Ser Tyr Pro Met His 1 5 <210> 2781 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 367 HC CDR2 <400> 2781 Val Ile Ser Tyr Asp Gly Ser Leu Lys Tyr Tyr Val Asp Ser Val Lys 1 5 10 15 Gly <210> 2782 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 367 HC CDR3 <400> 2782 Asp Ser Ser Cys Ser Gly Gly Ser Cys Phe Asp Tyr 1 5 10 <210> 2783 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 368 LC CDR1 <400> 2783 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2784 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 368 LC CDR2 <400> 2784 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2785 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 368 LC CDR3 <400> 2785 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 2786 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 368 HC CDR1 <400> 2786 Ser Asn Trp Ile Ala 1 5 <210> 2787 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 368 HC CDR2 <400> 2787 Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Asn Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 2788 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 368 HC CDR3 <400> 2788 Leu Ala Tyr Phe His Pro Gln Arg Asn Gly Gly Tyr Glu Tyr Tyr Phe 1 5 10 15 Asp Tyr <210> 2789 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 369 LC CDR1 <400> 2789 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2790 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 369 LC CDR2 <400> 2790 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2791 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 369 LC CDR3 <400> 2791 Gln Ser Tyr Asp Ser Arg Leu Arg Ala Val Val 1 5 10 <210> 2792 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 369 HC CDR1 <400> 2792 Thr Gln Tyr Leu His 1 5 <210> 2793 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 369 HC CDR2 <400> 2793 Ile Ile Asn Pro Tyr Gly Gly Ser Thr Thr Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2794 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 369 HC CDR3 <400> 2794 Ser Pro Ser Gly Tyr Tyr Gly Asp Tyr Glu Gly Asp Ala Phe Asp Ile 1 5 10 15 <210> 2795 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 370 LC CDR1 <400> 2795 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2796 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 370 LC CDR2 <400> 2796 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2797 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 370 LC CDR3 <400> 2797 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 2798 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 370 HC CDR1 <400> 2798 Ser Tyr Val Ile Ser 1 5 <210> 2799 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 370 HC CDR2 <400> 2799 Arg Ile Ile Pro Ile Phe Gly Thr Val Lys Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2800 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 370 HC CDR3 <400> 2800 Asp Leu Pro Gly Asp Ser Arg Asp Gly Tyr Asn Tyr Asp Ala Phe Asp 1 5 10 15 Ile <210> 2801 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 371 LC CDR1 <400> 2801 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2802 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 371 LC CDR2 <400> 2802 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2803 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 371 LC CDR3 <400> 2803 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 2804 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 371 HC CDR1 <400> 2804 Ser Phe Ala Met His 1 5 <210> 2805 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 371 HC CDR2 <400> 2805 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2806 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 371 HC CDR3 <400> 2806 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 2807 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 372 LC CDR1 <400> 2807 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 2808 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 372 LC CDR2 <400> 2808 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 2809 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 372 LC CDR3 <400> 2809 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 2810 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 372 HC CDR1 <400> 2810 Ser Tyr Ala Ile Ser 1 5 <210> 2811 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 372 HC CDR2 <400> 2811 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2812 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 372 HC CDR3 <400> 2812 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 2813 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 373 LC CDR1 <400> 2813 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2814 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 373 LC CDR2 <400> 2814 Asn Asn Asn Gln Arg Pro Ser 1 5 <210> 2815 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 373 LC CDR3 <400> 2815 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 2816 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 373 HC CDR1 <400> 2816 Ser Tyr Trp Ile Gly 1 5 <210> 2817 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 373 HC CDR2 <400> 2817 Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 2818 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 373 HC CDR3 <400> 2818 Gly Pro Asn Ile Tyr Asn Trp Phe Asp Ser 1 5 10 <210> 2819 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 374 LC CDR1 <400> 2819 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2820 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 374 LC CDR2 <400> 2820 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2821 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 374 LC CDR3 <400> 2821 Gln Gln Arg Arg Asn Trp Pro Pro Val Leu Thr 1 5 10 <210> 2822 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 374 HC CDR1 <400> 2822 Ser Tyr Ala Ile Ser 1 5 <210> 2823 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 374 HC CDR2 <400> 2823 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2824 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 374 HC CDR3 <400> 2824 Val Glu Gly Tyr Asp Ser Ser Gly Tyr Tyr Leu Asp Tyr 1 5 10 <210> 2825 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 375 LC CDR1 <400> 2825 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2826 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 375 LC CDR2 <400> 2826 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2827 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 375 LC CDR3 <400> 2827 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 2828 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 375 HC CDR1 <400> 2828 Asp Tyr Gly Met His 1 5 <210> 2829 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 375 HC CDR2 <400> 2829 Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2830 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 375 HC CDR3 <400> 2830 Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr Tyr Ala 1 5 10 15 Met Asp Val <210> 2831 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 376 LC CDR1 <400> 2831 Arg Ala Ser Gln Ser Val Ser Thr Phe Leu Ala 1 5 10 <210> 2832 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 376 LC CDR2 <400> 2832 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2833 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 376 LC CDR3 <400> 2833 Gln Gln Arg Ser Asn Trp Pro Pro Arg Ile Thr 1 5 10 <210> 2834 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 376 HC CDR1 <400> 2834 Ser Tyr Ala Ile Ser 1 5 <210> 2835 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 376 HC CDR2 <400> 2835 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2836 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 376 HC CDR3 <400> 2836 Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr 1 5 10 <210> 2837 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 377 LC CDR1 <400> 2837 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2838 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 377 LC CDR2 <400> 2838 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 2839 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 377 LC CDR3 <400> 2839 Gln Gln Ser Tyr Ser Thr Pro Phe Thr 1 5 <210> 2840 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 377 HC CDR1 <400> 2840 Ser Tyr Ala Met His 1 5 <210> 2841 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 377 HC CDR2 <400> 2841 Val Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2842 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 377 HC CDR3 <400> 2842 Ala Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2843 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 378 LC CDR1 <400> 2843 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2844 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 378 LC CDR2 <400> 2844 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2845 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 378 LC CDR3 <400> 2845 Gln Gln Arg Ser Asn Trp Pro Pro Lys Tyr Thr 1 5 10 <210> 2846 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 378 HC CDR1 <400> 2846 Ser Tyr Ala Ile Ser 1 5 <210> 2847 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 378 HC CDR2 <400> 2847 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2848 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 378 HC CDR3 <400> 2848 Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Glu Tyr 1 5 10 <210> 2849 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 379 LC CDR1 <400> 2849 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2850 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 379 LC CDR2 <400> 2850 Lys Ala Ser Ser Leu Glu Ser 1 5 <210> 2851 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 379 LC CDR3 <400> 2851 Gln Gln Ser Tyr Ser Thr Trp Thr 1 5 <210> 2852 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 379 HC CDR1 <400> 2852 Ser Tyr Ala Met His 1 5 <210> 2853 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 379 HC CDR2 <400> 2853 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2854 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 379 HC CDR3 <400> 2854 Ala Arg Gly Gly Ser Tyr Leu Tyr Gly Met Asp Val 1 5 10 <210> 2855 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 380 LC CDR1 <400> 2855 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2856 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 380 LC CDR2 <400> 2856 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2857 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 380 LC CDR3 <400> 2857 Gln Gln Arg Arg Asn Trp Pro Pro Arg Ile Thr 1 5 10 <210> 2858 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 380 HC CDR1 <400> 2858 Ser Tyr Ala Ile Ser 1 5 <210> 2859 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 380 HC CDR2 <400> 2859 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2860 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 380 HC CDR3 <400> 2860 Val Glu Gly Tyr Asp Ser Ser Gly Tyr Tyr Leu Asp Tyr 1 5 10 <210> 2861 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 381 LC CDR1 <400> 2861 Ser Gly Ser Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 1 5 10 <210> 2862 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 381 LC CDR2 <400> 2862 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2863 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 381 LC CDR3 <400> 2863 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2864 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 381 HC CDR1 <400> 2864 Ser Tyr Tyr Met His 1 5 <210> 2865 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 381 HC CDR2 <400> 2865 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2866 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 381 HC CDR3 <400> 2866 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2867 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 382 LC CDR1 <400> 2867 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2868 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 382 LC CDR2 <400> 2868 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2869 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 382 LC CDR3 <400> 2869 Ala Ala Trp Asp Asp Ser Leu Gly Gly Pro Val 1 5 10 <210> 2870 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 382 HC CDR1 <400> 2870 Thr Tyr Gly Met His 1 5 <210> 2871 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 382 HC CDR2 <400> 2871 Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2872 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 382 HC CDR3 <400> 2872 Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2873 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 383 LC CDR1 <400> 2873 Arg Ala Ser Gln Ser Val Ser Ser Phe Leu Ala 1 5 10 <210> 2874 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 383 LC CDR2 <400> 2874 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2875 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 383 LC CDR3 <400> 2875 Gln Gln Arg Ser Asn Trp Pro Pro Lys Leu Thr 1 5 10 <210> 2876 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 383 HC CDR1 <400> 2876 Ser Tyr Ala Ile Ser 1 5 <210> 2877 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 383 HC CDR2 <400> 2877 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2878 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 383 HC CDR3 <400> 2878 Val Ser Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr 1 5 10 <210> 2879 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 384 LC CDR1 <400> 2879 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2880 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 384 LC CDR2 <400> 2880 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2881 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 384 LC CDR3 <400> 2881 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 2882 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 384 HC CDR1 <400> 2882 Thr Tyr Gly Met His 1 5 <210> 2883 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 384 HC CDR2 <400> 2883 Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2884 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 384 HC CDR3 <400> 2884 Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2885 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 385 LC CDR1 <400> 2885 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Ser 1 5 10 <210> 2886 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 385 LC CDR2 <400> 2886 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2887 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 385 LC CDR3 <400> 2887 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 2888 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 385 HC CDR1 <400> 2888 Gly Tyr Tyr Trp Ser 1 5 <210> 2889 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 385 HC CDR2 <400> 2889 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2890 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 385 HC CDR3 <400> 2890 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2891 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 386 LC CDR1 <400> 2891 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2892 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 386 LC CDR2 <400> 2892 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 2893 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 386 LC CDR3 <400> 2893 Gln Gln Ser Tyr Ser Thr Trp Thr 1 5 <210> 2894 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 386 HC CDR1 <400> 2894 Ser Tyr Ala Met His 1 5 <210> 2895 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 386 HC CDR2 <400> 2895 Val Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2896 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 386 HC CDR3 <400> 2896 Ala Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2897 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 387 LC CDR1 <400> 2897 Gln Ala Ser Gln Asp Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2898 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 387 LC CDR2 <400> 2898 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 2899 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 387 LC CDR3 <400> 2899 Gln Gln Ser Tyr Ser Thr Trp Thr 1 5 <210> 2900 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 387 HC CDR1 <400> 2900 Ser Tyr Ala Met His 1 5 <210> 2901 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 387 HC CDR2 <400> 2901 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2902 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 387 HC CDR3 <400> 2902 Ala Arg Gly Gly Ser Tyr Leu Tyr Gly Met Asp Val 1 5 10 <210> 2903 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 388 LC CDR1 <400> 2903 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2904 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 388 LC CDR2 <400> 2904 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 2905 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 388 LC CDR3 <400> 2905 Gln Gln Ser Tyr Ser Asn Pro Phe Thr 1 5 <210> 2906 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 388 HC CDR1 <400> 2906 Ser Tyr Ala Met His 1 5 <210> 2907 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 388 HC CDR2 <400> 2907 Val Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2908 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 388 HC CDR3 <400> 2908 Ala Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2909 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 389 LC CDR1 <400> 2909 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2910 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 389 LC CDR2 <400> 2910 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2911 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 389 LC CDR3 <400> 2911 Gln Gln Arg Ser Asn Trp Pro Pro Met Tyr Thr 1 5 10 <210> 2912 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 389 HC CDR1 <400> 2912 Ser Tyr Ala Ile Ile 1 5 <210> 2913 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 389 HC CDR2 <400> 2913 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2914 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 389 HC CDR3 <400> 2914 Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr 1 5 10 <210> 2915 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 390 LC CDR1 <400> 2915 Thr Gly Ser Arg Ser Asn Ile Gly Ile Asn Ser Val Asn 1 5 10 <210> 2916 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 390 LC CDR2 <400> 2916 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2917 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 390 LC CDR3 <400> 2917 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 2918 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 390 HC CDR1 <400> 2918 Gly Tyr Tyr Trp Ser 1 5 <210> 2919 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 390 HC CDR2 <400> 2919 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2920 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 390 HC CDR3 <400> 2920 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2921 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 391 LC CDR1 <400> 2921 Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2922 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 391 LC CDR2 <400> 2922 Ala Val Ser Lys Arg Pro Ser 1 5 <210> 2923 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 391 LC CDR3 <400> 2923 Ser Ser Tyr Thr Ser Ser Ser Gly Thr Leu Asn Val 1 5 10 <210> 2924 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 391 HC CDR1 <400> 2924 Thr Tyr Gly Met His 1 5 <210> 2925 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 391 HC CDR2 <400> 2925 Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2926 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 391 HC CDR3 <400> 2926 Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2927 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 392 LC CDR1 <400> 2927 Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn Phe Val Ser 1 5 10 <210> 2928 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 392 LC CDR2 <400> 2928 Asp Asn Asn Val Arg Pro Ser 1 5 <210> 2929 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 392 LC CDR3 <400> 2929 Ala Ala Trp Asp Thr Ser Leu Ser Ser Trp Val 1 5 10 <210> 2930 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 392 HC CDR1 <400> 2930 Ser Tyr Tyr Met His 1 5 <210> 2931 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 392 HC CDR2 <400> 2931 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2932 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 392 HC CDR3 <400> 2932 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2933 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 393 LC CDR1 <400> 2933 Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 1 5 10 <210> 2934 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 393 LC CDR2 <400> 2934 Arg Ala Ser Thr Leu Gln Ser 1 5 <210> 2935 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 393 LC CDR3 <400> 2935 Gln Gln Tyr Lys Thr Tyr Pro Leu Thr 1 5 <210> 2936 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 393 HC CDR1 <400> 2936 Ser Tyr Gly Met His 1 5 <210> 2937 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 393 HC CDR2 <400> 2937 Ala Ile Trp His Asp Gly Tyr Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2938 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 393 HC CDR3 <400> 2938 Gly Ser Lys Ala Ala Asp Tyr 1 5 <210> 2939 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 394 LC CDR1 <400> 2939 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 2940 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 394 LC CDR2 <400> 2940 Gln Asp Ser Lys Arg Pro Ser 1 5 <210> 2941 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 394 LC CDR3 <400> 2941 Gln Ala Trp Asp Ser Ser Thr Val 1 5 <210> 2942 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 394 HC CDR1 <400> 2942 Thr Tyr Gly Met His 1 5 <210> 2943 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 394 HC CDR2 <400> 2943 Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2944 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 394 HC CDR3 <400> 2944 Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2945 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 395 LC CDR1 <400> 2945 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2946 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 395 LC CDR2 <400> 2946 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2947 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 395 LC CDR3 <400> 2947 Gln Gln Arg Ser Asn Trp Pro Pro Met Tyr Thr 1 5 10 <210> 2948 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 395 HC CDR1 <400> 2948 Ser Tyr Ala Ile Ser 1 5 <210> 2949 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 395 HC CDR2 <400> 2949 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2950 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 395 HC CDR3 <400> 2950 Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Glu Tyr 1 5 10 <210> 2951 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 396 LC CDR1 <400> 2951 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2952 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 396 LC CDR2 <400> 2952 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 2953 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 396 LC CDR3 <400> 2953 Ser Ser Tyr Thr Ser Ser Ser Thr Arg Tyr Val 1 5 10 <210> 2954 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 396 HC CDR1 <400> 2954 Ser Tyr Ala Met Asn 1 5 <210> 2955 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 396 HC CDR2 <400> 2955 Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2956 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 396 HC CDR3 <400> 2956 Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser Glu Tyr 1 5 10 15 Tyr Phe Asp Tyr 20 <210> 2957 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 397 LC CDR1 <400> 2957 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2958 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 397 LC CDR2 <400> 2958 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2959 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 397 LC CDR3 <400> 2959 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Val 1 5 10 <210> 2960 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 397 HC CDR1 <400> 2960 Asn Tyr Gly Ile Ser 1 5 <210> 2961 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 397 HC CDR2 <400> 2961 Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 1 5 10 15 Gly <210> 2962 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 397 HC CDR3 <400> 2962 Pro Arg Gly Tyr Ser Gly Tyr Gly Ser Asn Trp Tyr Phe Asp Leu 1 5 10 15 <210> 2963 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 398 LC CDR1 <400> 2963 Arg Ala Ser Gln Ser Val Ser Ser Phe Leu Ala 1 5 10 <210> 2964 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 398 LC CDR2 <400> 2964 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2965 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 398 LC CDR3 <400> 2965 Gln Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 1 5 10 <210> 2966 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 398 HC CDR1 <400> 2966 Ser Tyr Ala Ile Ser 1 5 <210> 2967 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 398 HC CDR2 <400> 2967 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2968 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 398 HC CDR3 <400> 2968 Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr 1 5 10 <210> 2969 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 399 LC CDR1 <400> 2969 Arg Thr Thr Gln Asn Ile Asn Thr Tyr Leu Asn 1 5 10 <210> 2970 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 399 LC CDR2 <400> 2970 Ala Ala Ser Arg Leu Gln Ser 1 5 <210> 2971 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 399 LC CDR3 <400> 2971 Gln Arg Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 2972 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 399 HC CDR1 <400> 2972 Ser Tyr Ala Met His 1 5 <210> 2973 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 399 HC CDR2 <400> 2973 Leu Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2974 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 399 HC CDR3 <400> 2974 Ala Thr Tyr Gly Ser Tyr Tyr Tyr Gly Met Asp Ala 1 5 10 <210> 2975 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 400 LC CDR1 <400> 2975 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2976 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 400 LC CDR2 <400> 2976 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2977 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 400 LC CDR3 <400> 2977 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 2978 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 400 HC CDR1 <400> 2978 Asn Tyr Ala Met Asn 1 5 <210> 2979 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 400 HC CDR2 <400> 2979 Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2980 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> No. 400 HC CDR3 <400> 2980 Gly Tyr Ala Leu Asn Pro 1 5 <210> 2981 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 401 LC CDR1 <400> 2981 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Ser 1 5 10 <210> 2982 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 401 LC CDR2 <400> 2982 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2983 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 401 LC CDR3 <400> 2983 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2984 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 401 HC CDR1 <400> 2984 Ser Tyr Tyr Met His 1 5 <210> 2985 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 401 HC CDR2 <400> 2985 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2986 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 401 HC CDR3 <400> 2986 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2987 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 402 LC CDR1 <400> 2987 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2988 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 402 LC CDR2 <400> 2988 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2989 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 402 LC CDR3 <400> 2989 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val 1 5 10 <210> 2990 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 402 HC CDR1 <400> 2990 Ser Tyr Tyr Met His 1 5 <210> 2991 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 402 HC CDR2 <400> 2991 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2992 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 402 HC CDR3 <400> 2992 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2993 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 403 LC CDR1 <400> 2993 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2994 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 403 LC CDR2 <400> 2994 Asp Asn Ser Arg Arg Pro Ser 1 5 <210> 2995 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 403 LC CDR3 <400> 2995 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2996 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 403 HC CDR1 <400> 2996 Ser Tyr Tyr Met His 1 5 <210> 2997 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 403 HC CDR2 <400> 2997 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2998 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 403 HC CDR3 <400> 2998 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2999 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 404 LC CDR1 <400> 2999 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3000 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 404 LC CDR2 <400> 3000 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 3001 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 404 LC CDR3 <400> 3001 Ala Ala Trp Asp Asp Ser Leu Ser Ala Trp Val 1 5 10 <210> 3002 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 404 HC CDR1 <400> 3002 Ser Tyr Tyr Met His 1 5 <210> 3003 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 404 HC CDR2 <400> 3003 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 3004 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 404 HC CDR3 <400> 3004 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 3005 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 405 LC CDR1 <400> 3005 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3006 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 405 LC CDR2 <400> 3006 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3007 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 405 LC CDR3 <400> 3007 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Trp Val 1 5 10 <210> 3008 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 405 HC CDR1 <400> 3008 Ser Tyr Tyr Met His 1 5 <210> 3009 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 405 HC CDR2 <400> 3009 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 3010 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 405 HC CDR3 <400> 3010 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 3011 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 406 LC CDR1 <400> 3011 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3012 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 406 LC CDR2 <400> 3012 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3013 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 406 LC CDR3 <400> 3013 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 3014 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 406 HC CDR1 <400> 3014 Ser Tyr Tyr Met His 1 5 <210> 3015 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 406 HC CDR2 <400> 3015 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Ser <210> 3016 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 406 HC CDR3 <400> 3016 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 3017 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 407 LC CDR1 <400> 3017 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3018 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 407 LC CDR2 <400> 3018 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3019 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 407 LC CDR3 <400> 3019 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 3020 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 407 HC CDR1 <400> 3020 Arg Tyr Ala Met Ser 1 5 <210> 3021 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 407 HC CDR2 <400> 3021 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3022 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 407 HC CDR3 <400> 3022 Val Arg Tyr Tyr Asp Phe Trp Ser Gly Trp Asp Val Met Asp Val 1 5 10 15 <210> 3023 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 408 LC CDR1 <400> 3023 Ser Gly Ser Ser Ser Ser Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3024 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 408 LC CDR2 <400> 3024 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3025 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 408 LC CDR3 <400> 3025 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 3026 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 408 HC CDR1 <400> 3026 Ser Tyr Tyr Met His 1 5 <210> 3027 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 408 HC CDR2 <400> 3027 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 3028 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 408 HC CDR3 <400> 3028 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 3029 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 409 LC CDR1 <400> 3029 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3030 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 409 LC CDR2 <400> 3030 Asp Asn Asn Val Arg Pro Ser 1 5 <210> 3031 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 409 LC CDR3 <400> 3031 Ala Ala Trp Asp Thr Ser Leu Ser Ser Trp Val 1 5 10 <210> 3032 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 409 HC CDR1 <400> 3032 Ser Tyr Tyr Met His 1 5 <210> 3033 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 409 HC CDR2 <400> 3033 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 3034 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 409 HC CDR3 <400> 3034 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 3035 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 410 LC CDR1 <400> 3035 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3036 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 410 LC CDR2 <400> 3036 Asp Asn Asn Gln Arg Pro Ser 1 5 <210> 3037 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 410 LC CDR3 <400> 3037 Gly Thr Trp Asp Thr Ser Leu Ser Ala Trp Val 1 5 10 <210> 3038 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 410 HC CDR1 <400> 3038 Ser Tyr Tyr Met His 1 5 <210> 3039 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 410 HC CDR2 <400> 3039 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 3040 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 410 HC CDR3 <400> 3040 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 3041 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 411 LC CDR1 <400> 3041 Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn Tyr Val Ser 1 5 10 <210> 3042 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 411 LC CDR2 <400> 3042 Asp Asn Asn Arg Arg Pro Ser 1 5 <210> 3043 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 411 LC CDR3 <400> 3043 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Ala 1 5 10 <210> 3044 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 411 HC CDR1 <400> 3044 Ser Tyr Tyr Met His 1 5 <210> 3045 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 411 HC CDR2 <400> 3045 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3046 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 411 HC CDR3 <400> 3046 Gly Gly Asp His Gly Met Asp Val 1 5 <210> 3047 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 412 LC CDR1 <400> 3047 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3048 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 412 LC CDR2 <400> 3048 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3049 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 412 LC CDR3 <400> 3049 Ala Ala Trp Asp Asp Ser Leu Asn Gly Thr Val 1 5 10 <210> 3050 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 412 HC CDR1 <400> 3050 Gly Tyr Tyr Trp Ser 1 5 <210> 3051 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 412 HC CDR2 <400> 3051 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3052 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 412 HC CDR3 <400> 3052 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 3053 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 413 LC CDR1 <400> 3053 Ser Gly Asp Val Leu Ala Lys Lys Tyr Ala Arg 1 5 10 <210> 3054 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 413 LC CDR2 <400> 3054 Lys Asp Ser Glu Arg Pro Ser 1 5 <210> 3055 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 413 LC CDR3 <400> 3055 Tyr Ser Ala Ala Asp Asn Asn Gly Val 1 5 <210> 3056 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 413 HC CDR1 <400> 3056 Ser Asp Ala Met His 1 5 <210> 3057 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 413 HC CDR2 <400> 3057 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3058 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 413 HC CDR3 <400> 3058 Glu Ala Thr Tyr Asp Ser Ser Gly Arg Pro Thr Gly Asp Tyr Gly Met 1 5 10 15 Asp Val <210> 3059 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 414 LC CDR1 <400> 3059 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3060 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 414 LC CDR2 <400> 3060 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3061 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 414 LC CDR3 <400> 3061 Gln Gln Arg Ser Asn Trp Pro Pro Arg Ile Thr 1 5 10 <210> 3062 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 414 HC CDR1 <400> 3062 Ser Tyr Ala Ile Ser 1 5 <210> 3063 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 414 HC CDR2 <400> 3063 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3064 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 414 HC CDR3 <400> 3064 Val Thr Gly Tyr Asp Gly Ser Gly Tyr Tyr Gln Asp Tyr 1 5 10 <210> 3065 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 415 LC CDR1 <400> 3065 Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3066 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 415 LC CDR2 <400> 3066 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3067 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 415 LC CDR3 <400> 3067 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 3068 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 415 HC CDR1 <400> 3068 Gly Tyr Tyr Trp Ser 1 5 <210> 3069 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 415 HC CDR2 <400> 3069 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3070 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 415 HC CDR3 <400> 3070 Gly Arg Tyr Tyr Ser Ser Trp Tyr Gly Pro Arg Thr Trp Phe Asp Pro 1 5 10 15 <210> 3071 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 416 LC CDR1 <400> 3071 Arg Ala Ser Gln Ser Val Ser Thr Tyr Leu Ser 1 5 10 <210> 3072 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 416 LC CDR2 <400> 3072 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3073 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 416 LC CDR3 <400> 3073 Leu Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 1 5 10 <210> 3074 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 416 HC CDR1 <400> 3074 Ser Tyr Ala Ile Ser 1 5 <210> 3075 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 416 HC CDR2 <400> 3075 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3076 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 416 HC CDR3 <400> 3076 Ala Ser Gly Tyr Asp Ser Ser Gly Tyr Tyr Ser Asp Tyr 1 5 10 <210> 3077 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 417 LC CDR1 <400> 3077 Arg Ala Ser Gln Ser Val Ser Ser Phe Leu Ala 1 5 10 <210> 3078 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 417 LC CDR2 <400> 3078 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3079 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 417 LC CDR3 <400> 3079 Gln Gln Arg Ser Asn Trp Pro Pro Ser Ile Thr 1 5 10 <210> 3080 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 417 HC CDR1 <400> 3080 Ser Tyr Ala Ile Ser 1 5 <210> 3081 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 417 HC CDR2 <400> 3081 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3082 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 417 HC CDR3 <400> 3082 Val Gly Thr Tyr Asp Ser Ser Gly Tyr Ser Phe Asp Tyr 1 5 10 <210> 3083 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 418 LC CDR1 <400> 3083 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3084 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 418 LC CDR2 <400> 3084 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3085 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 418 LC CDR3 <400> 3085 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 3086 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 418 HC CDR1 <400> 3086 Arg Tyr Ala Met Ser 1 5 <210> 3087 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 418 HC CDR2 <400> 3087 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3088 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 418 HC CDR3 <400> 3088 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 3089 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 419 LC CDR1 <400> 3089 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asp 1 5 10 <210> 3090 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 419 LC CDR2 <400> 3090 Asn Asn Asn Gln Arg Pro Ser 1 5 <210> 3091 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 419 LC CDR3 <400> 3091 Ala Ala Trp Asp Asp Ser Leu Asn Ala Pro Trp Val 1 5 10 <210> 3092 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 419 HC CDR1 <400> 3092 Ser Tyr Ala Met His 1 5 <210> 3093 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 419 HC CDR2 <400> 3093 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3094 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 419 HC CDR3 <400> 3094 Pro Arg Gly Gly Asn Tyr Arg Gly Ala Leu Asp Ile 1 5 10 <210> 3095 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 420 LC CDR1 <400> 3095 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3096 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 420 LC CDR2 <400> 3096 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3097 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 420 LC CDR3 <400> 3097 Gln Gln Tyr Gly Ser Ser Pro Pro Ile Thr 1 5 10 <210> 3098 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 420 HC CDR1 <400> 3098 Ser Tyr Ala Ile Ser 1 5 <210> 3099 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 420 HC CDR2 <400> 3099 Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3100 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 420 HC CDR3 <400> 3100 Asp Pro Thr Gly Trp Tyr Ser Gly Tyr Phe Asp Tyr 1 5 10 <210> 3101 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 421 LC CDR1 <400> 3101 Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Leu Val Ser 1 5 10 <210> 3102 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 421 LC CDR2 <400> 3102 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 3103 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 421 LC CDR3 <400> 3103 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val 1 5 10 <210> 3104 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 421 HC CDR1 <400> 3104 Asn Tyr Gly Met His 1 5 <210> 3105 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 421 HC CDR2 <400> 3105 Val Met Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3106 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 421 HC CDR3 <400> 3106 Pro Asp Asp Ser Ser Gly Tyr Tyr Pro Asp Tyr 1 5 10 <210> 3107 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 422 LC CDR1 <400> 3107 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 3108 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 422 LC CDR2 <400> 3108 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 3109 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 422 LC CDR3 <400> 3109 Ser Ser Tyr Thr Thr Ser Ser Thr Trp Val 1 5 10 <210> 3110 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 422 HC CDR1 <400> 3110 Glu Leu Ser Ile His 1 5 <210> 3111 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 422 HC CDR2 <400> 3111 Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3112 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 422 HC CDR3 <400> 3112 Ser Pro Ala Val Thr Thr Ala Gly Trp Phe Asp Pro 1 5 10 <210> 3113 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 423 LC CDR1 <400> 3113 Thr Gly Thr Arg Gly Asp Ile Gly Ala Tyr Asp Gly Val Ser 1 5 10 <210> 3114 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 423 LC CDR2 <400> 3114 Ala Val Thr Gln Arg Pro Ser 1 5 <210> 3115 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 423 LC CDR3 <400> 3115 Ser Ser Tyr Thr Ser Ser Ser Ser Trp Val 1 5 10 <210> 3116 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 423 HC CDR1 <400> 3116 Glu Leu Ser Met His 1 5 <210> 3117 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 423 HC CDR2 <400> 3117 Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3118 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 423 HC CDR3 <400> 3118 Ser Pro Ala Ile Ile Arg Val Asp Trp Phe Asp Pro 1 5 10 <210> 3119 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 424 LC CDR1 <400> 3119 Thr Gly Thr Arg Gly Asp Ile Gly Ala Tyr Asp Gly Val Ser 1 5 10 <210> 3120 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 424 LC CDR2 <400> 3120 Ala Val Thr Gln Arg Pro Ser 1 5 <210> 3121 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 424 LC CDR3 <400> 3121 Ser Ser Tyr Thr Ser Ser Ser Ser Trp Val 1 5 10 <210> 3122 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 424 HC CDR1 <400> 3122 Arg Tyr Ala Met Ser 1 5 <210> 3123 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 424 HC CDR2 <400> 3123 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3124 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 424 HC CDR3 <400> 3124 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 3125 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 425 LC CDR1 <400> 3125 Ser Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 3126 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 425 LC CDR2 <400> 3126 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 3127 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 425 LC CDR3 <400> 3127 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 3128 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 425 HC CDR1 <400> 3128 Ser Tyr Ala Met His 1 5 <210> 3129 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 425 HC CDR2 <400> 3129 Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3130 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 425 HC CDR3 <400> 3130 Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val 1 5 10 <210> 3131 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 426 LC CDR1 <400> 3131 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 3132 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 426 LC CDR2 <400> 3132 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 3133 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 426 LC CDR3 <400> 3133 Ser Ser Tyr Thr Ser Ser Ser Thr Pro Trp Val 1 5 10 <210> 3134 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 426 HC CDR1 <400> 3134 Ser Tyr Ala Met His 1 5 <210> 3135 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 426 HC CDR2 <400> 3135 Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3136 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 426 HC CDR3 <400> 3136 Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val 1 5 10 <210> 3137 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 427 LC CDR1 <400> 3137 Thr Gly Thr Asn Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 3138 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 427 LC CDR2 <400> 3138 Asp Val Thr Lys Arg Pro Ser 1 5 <210> 3139 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 427 LC CDR3 <400> 3139 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 3140 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 427 HC CDR1 <400> 3140 Ser Tyr Ala Met His 1 5 <210> 3141 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 427 HC CDR2 <400> 3141 Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3142 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 427 HC CDR3 <400> 3142 Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val 1 5 10 <210> 3143 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 428 LC CDR1 <400> 3143 Thr Gly Thr Ser Thr Asp Ile Gly Arg Tyr Asn Tyr Val Ser 1 5 10 <210> 3144 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 428 LC CDR2 <400> 3144 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 3145 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 428 LC CDR3 <400> 3145 Ser Ser Tyr Thr Ser Ser Ser Thr Tyr Ala 1 5 10 <210> 3146 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 428 HC CDR1 <400> 3146 Glu Val Ala Ile His 1 5 <210> 3147 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 428 HC CDR2 <400> 3147 Gly Phe Asp Pro Glu Asp Gly Glu Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3148 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 428 HC CDR3 <400> 3148 Gly Pro Val Leu Gly Leu Ser Lys Trp Leu Glu Phe Asp Pro 1 5 10 <210> 3149 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 429 LC CDR1 <400> 3149 Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr Asn Tyr Val Ser 1 5 10 <210> 3150 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 429 LC CDR2 <400> 3150 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 3151 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 429 LC CDR3 <400> 3151 Asn Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 3152 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 429 HC CDR1 <400> 3152 Glu Val Ala Ile His 1 5 <210> 3153 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 429 HC CDR2 <400> 3153 Gly Phe Asp Pro Glu Asp Gly Glu Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3154 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 429 HC CDR3 <400> 3154 Gly Pro Val Leu Gly Leu Ser Lys Trp Leu Glu Phe Asp Pro 1 5 10 <210> 3155 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 430 LC CDR1 <400> 3155 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3156 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 430 LC CDR2 <400> 3156 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3157 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 430 LC CDR3 <400> 3157 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 3158 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 430 HC CDR1 <400> 3158 Arg Tyr Ala Met Ser 1 5 <210> 3159 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 430 HC CDR2 <400> 3159 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3160 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 430 HC CDR3 <400> 3160 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 3161 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 431 LC CDR1 <400> 3161 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3162 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 431 LC CDR2 <400> 3162 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3163 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 431 LC CDR3 <400> 3163 Glu Ala Trp Asp Ser Ser Leu Ser Ala Val Leu 1 5 10 <210> 3164 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 431 HC CDR1 <400> 3164 Arg Tyr Ala Met Ser 1 5 <210> 3165 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 431 HC CDR2 <400> 3165 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3166 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 431 HC CDR3 <400> 3166 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 3167 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 432 LC CDR1 <400> 3167 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3168 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 432 LC CDR2 <400> 3168 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3169 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 432 LC CDR3 <400> 3169 Gly Thr Trp Asp Thr Ser Leu Ser Ala Gly Val 1 5 10 <210> 3170 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 432 HC CDR1 <400> 3170 Arg Tyr Ala Met Ser 1 5 <210> 3171 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 432 HC CDR2 <400> 3171 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3172 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 432 HC CDR3 <400> 3172 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 3173 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 433 LC CDR1 <400> 3173 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3174 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 433 LC CDR2 <400> 3174 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3175 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 433 LC CDR3 <400> 3175 Gly Thr Trp Asp Ser Ser Leu Ser Asp Val Val 1 5 10 <210> 3176 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 433 HC CDR1 <400> 3176 Arg Tyr Ala Met Ser 1 5 <210> 3177 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 433 HC CDR2 <400> 3177 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3178 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 433 HC CDR3 <400> 3178 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 3179 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 434 LC CDR1 <400> 3179 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3180 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 434 LC CDR2 <400> 3180 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3181 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 434 LC CDR3 <400> 3181 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 3182 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 434 HC CDR1 <400> 3182 Arg Tyr Ala Met Ser 1 5 <210> 3183 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 434 HC CDR2 <400> 3183 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3184 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 434 HC CDR3 <400> 3184 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 3185 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 435 LC CDR1 <400> 3185 Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 3186 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 435 LC CDR2 <400> 3186 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 3187 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 435 LC CDR3 <400> 3187 Gln Gln Tyr Gly Ser Ser Pro Pro Thr 1 5 <210> 3188 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 435 HC CDR1 <400> 3188 Asn Tyr Val Ile Asn 1 5 <210> 3189 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 435 HC CDR2 <400> 3189 Gly Phe Ile Pro Val Phe Gly Ile Ala Asp Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3190 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 435 HC CDR3 <400> 3190 Ser Gly Leu Phe Asp Trp Leu Leu Pro Arg Ser Arg His Arg Asp Tyr 1 5 10 15 Phe Asp Tyr <210> 3191 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 436 LC CDR1 <400> 3191 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3192 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 436 LC CDR2 <400> 3192 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3193 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 436 LC CDR3 <400> 3193 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 3194 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 436 HC CDR1 <400> 3194 Ser Tyr Ala Ile Ser 1 5 <210> 3195 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 436 HC CDR2 <400> 3195 Gly Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3196 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 436 HC CDR3 <400> 3196 Asp Pro Thr Ser Arg Ser Thr Tyr Tyr Tyr Tyr Ser Gly Ser Tyr Tyr 1 5 10 15 Pro <210> 3197 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 437 LC CDR1 <400> 3197 Ser Gly Ser Gly Ser Asn Ile Gly Ser Asn Tyr Val His 1 5 10 <210> 3198 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 437 LC CDR2 <400> 3198 Arg Asn Ser Gln Arg Pro Ser 1 5 <210> 3199 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 437 LC CDR3 <400> 3199 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 3200 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 437 HC CDR1 <400> 3200 Ser Tyr Ala Ile Ser 1 5 <210> 3201 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 437 HC CDR2 <400> 3201 Gly Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3202 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 437 HC CDR3 <400> 3202 Asp Pro Thr Ser Arg Ser Thr Tyr Tyr Tyr Tyr Ser Gly Ser Tyr Tyr 1 5 10 15 Pro <210> 3203 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 438 LC CDR1 <400> 3203 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 3204 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 438 LC CDR2 <400> 3204 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 3205 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 438 LC CDR3 <400> 3205 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 3206 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 438 HC CDR1 <400> 3206 Glu Leu Pro Ile His 1 5 <210> 3207 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 438 HC CDR2 <400> 3207 Arg Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Asn Phe Gln 1 5 10 15 Gly <210> 3208 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 438 HC CDR3 <400> 3208 Asp Leu Thr Thr Val Thr Asn Pro Leu Asn Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 3209 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 439 LC CDR1 <400> 3209 Ser Gly Ser Ser Ser Asn Val Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 3210 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 439 LC CDR2 <400> 3210 Arg Asn Ser Gln Arg Pro Ser 1 5 <210> 3211 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 439 LC CDR3 <400> 3211 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Met 1 5 10 <210> 3212 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 439 HC CDR1 <400> 3212 Ser Tyr Gly Thr Thr 1 5 <210> 3213 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 439 HC CDR2 <400> 3213 Trp Ile Ser Gly Tyr Asn Glu Asn Ser Thr His Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3214 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 439 HC CDR3 <400> 3214 Asp Ala Leu Arg Tyr Asp Ile Leu Thr Gly Phe Thr Gly Phe Asp Tyr 1 5 10 15 <210> 3215 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 440 LC CDR1 <400> 3215 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3216 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 440 LC CDR2 <400> 3216 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3217 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 440 LC CDR3 <400> 3217 Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 1 5 10 <210> 3218 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 440 HC CDR1 <400> 3218 Ser Tyr Ala Met Ser 1 5 <210> 3219 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 440 HC CDR2 <400> 3219 Ala Ile Ser Gly Ser Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3220 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 440 HC CDR3 <400> 3220 Val Arg Tyr Tyr Asp Phe Trp Ser Gly Trp Asp Val Met Asp Val 1 5 10 15 <210> 3221 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 441 LC CDR1 <400> 3221 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 3222 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 441 LC CDR2 <400> 3222 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3223 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 441 LC CDR3 <400> 3223 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 3224 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 441 HC CDR1 <400> 3224 Ser Tyr Trp Met Ser 1 5 <210> 3225 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 441 HC CDR2 <400> 3225 Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 1 5 10 15 Gly <210> 3226 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 441 HC CDR3 <400> 3226 Gly Thr Tyr Tyr Tyr Asp Ser Ser Gly Pro Leu Asn Trp Phe Asp Pro 1 5 10 15 <210> 3227 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 442 LC CDR1 <400> 3227 Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3228 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 442 LC CDR2 <400> 3228 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3229 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 442 LC CDR3 <400> 3229 Gln Gln Gly Leu Thr 1 5 <210> 3230 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 442 HC CDR1 <400> 3230 Ser Tyr Ala Ile Ser 1 5 <210> 3231 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 442 HC CDR2 <400> 3231 Gly Ile Ile Pro Phe Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3232 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 442 HC CDR3 <400> 3232 Gly Lys Pro Tyr Tyr Cys Thr Gly Ser Thr Cys Tyr Gln Pro Leu Gly 1 5 10 15 Pro <210> 3233 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 443 LC CDR1 <400> 3233 Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 3234 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 443 LC CDR2 <400> 3234 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 3235 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 443 LC CDR3 <400> 3235 Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 1 5 <210> 3236 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 443 HC CDR1 <400> 3236 Ser Ser Pro Met His 1 5 <210> 3237 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 443 HC CDR2 <400> 3237 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3238 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 443 HC CDR3 <400> 3238 Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val 1 5 10 <210> 3239 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 444 LC CDR1 <400> 3239 Thr Gly Thr Ser Ser Asp Val Gly Asn Tyr Asn Tyr Val Ser 1 5 10 <210> 3240 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 444 LC CDR2 <400> 3240 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 3241 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 444 LC CDR3 <400> 3241 Ser Ser Tyr Thr Ser Ser Gly Thr Leu Val 1 5 10 <210> 3242 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 444 HC CDR1 <400> 3242 Glu Leu Ser Ile His 1 5 <210> 3243 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 444 HC CDR2 <400> 3243 Gly Phe Asp Pro Glu Asn Gly Glu Thr Ile His Ala Gln Arg Phe Gln 1 5 10 15 Gly <210> 3244 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 444 HC CDR3 <400> 3244 Ser Thr Pro Met Ile Arg Ala Ser Trp Phe Asp Pro 1 5 10 <210> 3245 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 445 LC CDR1 <400> 3245 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Asn 1 5 10 <210> 3246 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 445 LC CDR2 <400> 3246 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3247 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 445 LC CDR3 <400> 3247 Ala Thr Trp Asp Asp Ser Leu Asn Gly Gln Val 1 5 10 <210> 3248 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 445 HC CDR1 <400> 3248 Asp Tyr Trp Met Ser 1 5 <210> 3249 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 445 HC CDR2 <400> 3249 Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 1 5 10 15 Gly <210> 3250 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> No. 445 HC CDR3 <400> 3250 Gly Tyr Ser Gly Asn Phe 1 5 <210> 3251 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 446 LC CDR1 <400> 3251 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3252 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 446 LC CDR2 <400> 3252 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3253 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 446 LC CDR3 <400> 3253 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 3254 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 446 HC CDR1 <400> 3254 Ser Tyr Ala Ile Ile 1 5 <210> 3255 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 446 HC CDR2 <400> 3255 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3256 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 446 HC CDR3 <400> 3256 Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr 1 5 10 <210> 3257 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 447 LC CDR1 <400> 3257 Arg Ala Ser Gln Ser Val Gly Arg Asn Tyr Leu Ala 1 5 10 <210> 3258 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 447 LC CDR2 <400> 3258 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 3259 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 447 LC CDR3 <400> 3259 Gln Gln Tyr Gly Ser Ser Pro Ile Thr 1 5 <210> 3260 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 447 HC CDR1 <400> 3260 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3261 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 447 HC CDR2 <400> 3261 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3262 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 447 HC CDR3 <400> 3262 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3263 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 448 LC CDR1 <400> 3263 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3264 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 448 LC CDR2 <400> 3264 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3265 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 448 LC CDR3 <400> 3265 His Gln Tyr Gly Thr Ser Pro Phe Thr 1 5 <210> 3266 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 448 HC CDR1 <400> 3266 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3267 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 448 HC CDR2 <400> 3267 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3268 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 448 HC CDR3 <400> 3268 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3269 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 449 LC CDR1 <400> 3269 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 3270 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 449 LC CDR2 <400> 3270 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 3271 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 449 LC CDR3 <400> 3271 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 3272 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 449 HC CDR1 <400> 3272 Ser Gly Gly Tyr Tyr Trp Ser 1 5 <210> 3273 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 449 HC CDR2 <400> 3273 Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3274 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 449 HC CDR3 <400> 3274 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3275 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 450 LC CDR1 <400> 3275 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 3276 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 450 LC CDR2 <400> 3276 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 3277 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 450 LC CDR3 <400> 3277 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 3278 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 450 HC CDR1 <400> 3278 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3279 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 450 HC CDR2 <400> 3279 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3280 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 450 HC CDR3 <400> 3280 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3281 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 451 LC CDR1 <400> 3281 Arg Ala Ser Gln Ser Val Asn Ser Tyr Ser Ala 1 5 10 <210> 3282 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 451 LC CDR2 <400> 3282 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3283 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 451 LC CDR3 <400> 3283 Gln Gln Tyr His Thr Ser Pro Ile Thr 1 5 <210> 3284 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 451 HC CDR1 <400> 3284 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3285 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 451 HC CDR2 <400> 3285 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3286 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 451 HC CDR3 <400> 3286 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3287 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 452 LC CDR1 <400> 3287 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3288 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 452 LC CDR2 <400> 3288 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3289 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 452 LC CDR3 <400> 3289 Gln Gln Tyr Gly Ser Ser Pro Ile Thr 1 5 <210> 3290 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 452 HC CDR1 <400> 3290 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3291 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 452 HC CDR2 <400> 3291 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3292 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 452 HC CDR3 <400> 3292 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3293 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 453 LC CDR1 <400> 3293 Thr Gly Thr Ser Ser Asn Val Gly Asp Tyr Asn Tyr Val Ser 1 5 10 <210> 3294 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 453 LC CDR2 <400> 3294 Asp Val Thr Asn Arg Pro Ser 1 5 <210> 3295 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 453 LC CDR3 <400> 3295 Ser Ser Tyr Thr Ser Gly Ser Thr Pro Val Val 1 5 10 <210> 3296 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 453 HC CDR1 <400> 3296 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3297 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 453 HC CDR2 <400> 3297 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3298 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 453 HC CDR3 <400> 3298 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3299 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 454 LC CDR1 <400> 3299 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 3300 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 454 LC CDR2 <400> 3300 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 3301 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 454 LC CDR3 <400> 3301 Gln Gln Tyr Gly Thr Ser Pro Leu Thr 1 5 <210> 3302 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 454 HC CDR1 <400> 3302 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3303 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 454 HC CDR2 <400> 3303 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3304 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 454 HC CDR3 <400> 3304 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3305 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 455 LC CDR1 <400> 3305 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 3306 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 455 LC CDR2 <400> 3306 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 3307 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 455 LC CDR3 <400> 3307 Gln Gln Tyr Gly Ser Ser Pro Leu Ala 1 5 <210> 3308 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 455 HC CDR1 <400> 3308 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3309 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 455 HC CDR2 <400> 3309 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3310 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 455 HC CDR3 <400> 3310 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3311 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 456 LC CDR1 <400> 3311 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3312 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 456 LC CDR2 <400> 3312 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3313 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 456 LC CDR3 <400> 3313 Gln Gln Tyr Gly Ser Ser Pro Gln Thr 1 5 <210> 3314 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 456 HC CDR1 <400> 3314 Gly Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3315 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 456 HC CDR2 <400> 3315 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3316 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 456 HC CDR3 <400> 3316 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3317 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 457 LC CDR1 <400> 3317 Arg Ala Ser Gln Ser Val Arg Asn Tyr Leu Ala 1 5 10 <210> 3318 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 457 LC CDR2 <400> 3318 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 3319 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 457 LC CDR3 <400> 3319 Gln Gln Tyr Gly Arg Ser Pro Leu Thr 1 5 <210> 3320 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 457 HC CDR1 <400> 3320 Gly Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3321 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 457 HC CDR2 <400> 3321 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3322 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 457 HC CDR3 <400> 3322 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3323 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 458 LC CDR1 <400> 3323 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3324 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 458 LC CDR2 <400> 3324 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 3325 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 458 LC CDR3 <400> 3325 Gln Gln His Gly Ser Ser Pro Phe Thr 1 5 <210> 3326 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 458 HC CDR1 <400> 3326 Gly Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3327 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 458 HC CDR2 <400> 3327 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3328 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 458 HC CDR3 <400> 3328 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3329 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 459 LC CDR1 <400> 3329 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 3330 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 459 LC CDR2 <400> 3330 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 3331 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 459 LC CDR3 <400> 3331 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 3332 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 459 HC CDR1 <400> 3332 Ser Tyr Ala Ile Ser 1 5 <210> 3333 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 459 HC CDR2 <400> 3333 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3334 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 459 HC CDR3 <400> 3334 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 3335 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 460 LC CDR1 <400> 3335 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3336 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 460 LC CDR2 <400> 3336 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3337 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 460 LC CDR3 <400> 3337 Ser Thr Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 3338 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 460 HC CDR1 <400> 3338 Ser Tyr Ala Ile Ser 1 5 <210> 3339 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 460 HC CDR2 <400> 3339 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3340 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 460 HC CDR3 <400> 3340 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 3341 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 461 LC CDR1 <400> 3341 Ser Gly Leu Thr Ser Asn Ile Gly Ser Asn Phe Val Tyr 1 5 10 <210> 3342 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 461 LC CDR2 <400> 3342 Arg Asn Asn Glu Arg Pro Ser 1 5 <210> 3343 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 461 LC CDR3 <400> 3343 Ala Ala Trp Asp Asp Thr Leu Val Gly Arg Val 1 5 10 <210> 3344 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 461 HC CDR1 <400> 3344 Ser Tyr Ala Ile Ser 1 5 <210> 3345 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 461 HC CDR2 <400> 3345 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 3346 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 461 HC CDR3 <400> 3346 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 3347 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 462 LC CDR1 <400> 3347 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3348 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 462 LC CDR2 <400> 3348 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3349 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 462 LC CDR3 <400> 3349 Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 1 5 10 <210> 3350 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 462 HC CDR1 <400> 3350 Ser His Trp Ile Ala 1 5 <210> 3351 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 462 HC CDR2 <400> 3351 Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3352 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 462 HC CDR3 <400> 3352 Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser 1 5 10 <210> 3353 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 463 LC CDR1 <400> 3353 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3354 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 463 LC CDR2 <400> 3354 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3355 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 463 LC CDR3 <400> 3355 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 3356 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 463 HC CDR1 <400> 3356 Ser His Trp Ile Ala 1 5 <210> 3357 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 463 HC CDR2 <400> 3357 Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3358 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 463 HC CDR3 <400> 3358 Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser 1 5 10 <210> 3359 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 464 LC CDR1 <400> 3359 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3360 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 464 LC CDR2 <400> 3360 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3361 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 464 LC CDR3 <400> 3361 Ala Ala Trp Asp Asp Ser Leu Asn Gly Ser Val Val 1 5 10 <210> 3362 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 464 HC CDR1 <400> 3362 Ser Tyr Trp Ile Ala 1 5 <210> 3363 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 464 HC CDR2 <400> 3363 Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3364 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 464 HC CDR3 <400> 3364 Gly Pro Asn Leu Tyr Asn Trp Phe Asp Phe 1 5 10 <210> 3365 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 465 LC CDR1 <400> 3365 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3366 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 465 LC CDR2 <400> 3366 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3367 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 465 LC CDR3 <400> 3367 Ala Ala Trp Asp Asp Ser Leu Asn Gly His Val Val 1 5 10 <210> 3368 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 465 HC CDR1 <400> 3368 Ser Tyr Trp Ile Ala 1 5 <210> 3369 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 465 HC CDR2 <400> 3369 Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3370 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 465 HC CDR3 <400> 3370 Gly Pro Asn Leu Tyr Asn Trp Phe Asp Phe 1 5 10 <210> 3371 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 466 LC CDR1 <400> 3371 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3372 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 466 LC CDR2 <400> 3372 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3373 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 466 LC CDR3 <400> 3373 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 3374 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 466 HC CDR1 <400> 3374 Ser His Trp Ile Ala 1 5 <210> 3375 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 466 HC CDR2 <400> 3375 Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3376 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 466 HC CDR3 <400> 3376 Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser 1 5 10 <210> 3377 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 467 LC CDR1 <400> 3377 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3378 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 467 LC CDR2 <400> 3378 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3379 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 467 LC CDR3 <400> 3379 Gln Gln Tyr Tyr Ser Thr Pro Phe Thr 1 5 <210> 3380 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 467 HC CDR1 <400> 3380 Asp Tyr Tyr Ile Gln 1 5 <210> 3381 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 467 HC CDR2 <400> 3381 Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe Gln 1 5 10 15 Gly <210> 3382 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 467 HC CDR3 <400> 3382 Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro 1 5 10 <210> 3383 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 468 LC CDR1 <400> 3383 Arg Ala Ser Gln Gly Ile Ser Asn Ser Leu Ala 1 5 10 <210> 3384 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 468 LC CDR2 <400> 3384 Ala Ala Ser Arg Leu Glu Ser 1 5 <210> 3385 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 468 LC CDR3 <400> 3385 Gln Gln Tyr Tyr Ser Thr Pro Phe Thr 1 5 <210> 3386 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 468 HC CDR1 <400> 3386 Asp Tyr Tyr Ile Gln 1 5 <210> 3387 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 468 HC CDR2 <400> 3387 Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe Gln 1 5 10 15 Gly <210> 3388 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 468 HC CDR3 <400> 3388 Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro 1 5 10 <210> 3389 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 469 LC CDR1 <400> 3389 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3390 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 469 LC CDR2 <400> 3390 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3391 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 469 LC CDR3 <400> 3391 Ala Ala Trp Asp Asp Ser Leu Asn Ser Gly Val 1 5 10 <210> 3392 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 469 HC CDR1 <400> 3392 Ser Asn Trp Ile Gly 1 5 <210> 3393 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 469 HC CDR2 <400> 3393 Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3394 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 469 HC CDR3 <400> 3394 Thr Tyr Gly Ser Gly Ser Tyr Ser Asp Phe Asp Tyr 1 5 10 <210> 3395 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 470 LC CDR1 <400> 3395 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3396 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 470 LC CDR2 <400> 3396 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3397 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 470 LC CDR3 <400> 3397 Ala Ala Trp Asp Asp Ser Leu Asn Gly Gly Val 1 5 10 <210> 3398 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 470 HC CDR1 <400> 3398 Ser Asn Trp Ile Gly 1 5 <210> 3399 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 470 HC CDR2 <400> 3399 Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3400 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 470 HC CDR3 <400> 3400 Thr Tyr Gly Ser Gly Ser Tyr Ser Asp Phe Asp Tyr 1 5 10 <210> 3401 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 471 LC CDR1 <400> 3401 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 3402 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 471 LC CDR2 <400> 3402 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 3403 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 471 LC CDR3 <400> 3403 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Val 1 5 10 <210> 3404 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 471 HC CDR1 <400> 3404 Asp Tyr Ala Met Ser 1 5 <210> 3405 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 471 HC CDR2 <400> 3405 Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Asn Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3406 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 471 HC CDR3 <400> 3406 Val Tyr Cys Gly Asp Asp Cys Tyr Pro Val Val Gly Thr Pro Gly Asp 1 5 10 15 Ala Phe Asp <210> 3407 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 472 LC CDR1 <400> 3407 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 3408 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 472 LC CDR2 <400> 3408 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 3409 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 472 LC CDR3 <400> 3409 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val 1 5 10 <210> 3410 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 472 HC CDR1 <400> 3410 Asp Tyr Ala Met Ser 1 5 <210> 3411 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 472 HC CDR2 <400> 3411 Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Asn Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3412 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 472 HC CDR3 <400> 3412 Val Tyr Cys Gly Asp Asp Cys Tyr Pro Val Val Gly Thr Pro Gly Asp 1 5 10 15 Ala Phe Asp <210> 3413 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 473 LC CDR1 <400> 3413 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3414 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 473 LC CDR2 <400> 3414 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3415 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 473 LC CDR3 <400> 3415 Ala Ala Trp Asp Asp Ser Leu Met Gln Gly Val 1 5 10 <210> 3416 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 473 HC CDR1 <400> 3416 Asn Tyr Trp Ile Ala 1 5 <210> 3417 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 473 HC CDR2 <400> 3417 Ile Ile Tyr Pro Tyr Asp Ser Asp Thr Arg Lys Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3418 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 473 HC CDR3 <400> 3418 Gln Asp Ser Gly Thr Tyr Gly Trp Ile Asp Tyr 1 5 10 <210> 3419 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 474 LC CDR1 <400> 3419 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 3420 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 474 LC CDR2 <400> 3420 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 3421 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 474 LC CDR3 <400> 3421 Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Trp Val 1 5 10 <210> 3422 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 474 HC CDR1 <400> 3422 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3423 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 474 HC CDR2 <400> 3423 Asn Phe Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3424 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 474 HC CDR3 <400> 3424 Gln Glu Trp Leu Arg Gly Gly Phe Asp Asp 1 5 10 <210> 3425 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 475 LC CDR1 <400> 3425 Ser Gly Ser Ser Ser Asn Val Gly Ser Asn Ile Val Asn 1 5 10 <210> 3426 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 475 LC CDR2 <400> 3426 Asn Asn Asn Gln Arg Pro Ser 1 5 <210> 3427 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 475 LC CDR3 <400> 3427 Ala Ala Trp Asp Asp Ser Leu Asn Ala Trp Val 1 5 10 <210> 3428 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 475 HC CDR1 <400> 3428 Asn His Trp Ile Ala 1 5 <210> 3429 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 475 HC CDR2 <400> 3429 Ile Ile Tyr Pro Tyr Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3430 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 475 HC CDR3 <400> 3430 Asn Pro Thr Val Thr Asn Trp Phe Asp Ser 1 5 10 <210> 3431 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 476 LC CDR1 <400> 3431 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 3432 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 476 LC CDR2 <400> 3432 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 3433 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 476 LC CDR3 <400> 3433 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Pro Asn Trp Val 1 5 10 <210> 3434 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 476 HC CDR1 <400> 3434 Ser Tyr Ala Ile Ser 1 5 <210> 3435 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 476 HC CDR2 <400> 3435 Gly Ile Ile Pro Phe Phe Gly Thr Ser Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3436 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 476 HC CDR3 <400> 3436 Gly Gln Phe Ser Asp Ser Ser Gly Tyr Gln His Pro Tyr Tyr Asp Tyr 1 5 10 15 Gly Met Asp <210> 3437 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 477 LC CDR1 <400> 3437 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 3438 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 477 LC CDR2 <400> 3438 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 3439 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 477 LC CDR3 <400> 3439 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val 1 5 10 <210> 3440 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 477 HC CDR1 <400> 3440 Thr His Ala Leu Ser 1 5 <210> 3441 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 477 HC CDR2 <400> 3441 Gly Ile Ile Pro Ile Phe Gly Pro Ala Asp Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3442 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 477 HC CDR3 <400> 3442 Gly Leu Ser Leu Gly Phe Cys Ser Ala Gly Ser Cys Tyr Asp Tyr Leu 1 5 10 15 Asp Tyr <210> 3443 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 478 LC CDR1 <400> 3443 Ser Gly Ser Ser Ser Asp Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3444 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 478 LC CDR2 <400> 3444 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3445 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 478 LC CDR3 <400> 3445 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 3446 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 478 HC CDR1 <400> 3446 Asn Tyr Ala Ile Asn 1 5 <210> 3447 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 478 HC CDR2 <400> 3447 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3448 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> No. 478 HC CDR3 <400> 3448 Asp Arg Tyr Pro Gly Tyr Tyr Asp Ile Leu Thr Gly Gln Ile Gly Thr 1 5 10 15 Gly Glu Arg Asn Ala Met Asp Val 20 <210> 3449 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 479 LC CDR1 <400> 3449 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 3450 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 479 LC CDR2 <400> 3450 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 3451 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 479 LC CDR3 <400> 3451 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 3452 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 479 HC CDR1 <400> 3452 Asn Tyr Pro Leu Thr 1 5 <210> 3453 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 479 HC CDR2 <400> 3453 Gly Ile Ile Pro Ile Ile Gly Ala Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3454 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 479 HC CDR3 <400> 3454 Gly Arg Gly Tyr Ser Gly Tyr Gly Ala Ala Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 3455 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 480 LC CDR1 <400> 3455 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 3456 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 480 LC CDR2 <400> 3456 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 3457 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 480 LC CDR3 <400> 3457 Gln Val Trp Asp Ser Ser Ser Asp His Trp Val 1 5 10 <210> 3458 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 480 HC CDR1 <400> 3458 Ser Tyr Tyr Ile His 1 5 <210> 3459 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 480 HC CDR2 <400> 3459 Phe Ile Asn Pro Ser Asp Val Thr Thr Tyr Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3460 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 480 HC CDR3 <400> 3460 Ser Arg Ile Ala Pro Thr Glu Asp Phe Phe Asp Tyr 1 5 10 <210> 3461 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 291 LC variable region <400> 3461 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Ser Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Arg Leu 85 90 95 Ser Ala Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3462 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 291 HC variable region <400> 3462 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Ser Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3463 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 292 LC variable region <400> 3463 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Phe Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Glu Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3464 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 292 HC variable region <400> 3464 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3465 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 293 LC variable region <400> 3465 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3466 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 293 HC variable region <400> 3466 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Arg Tyr Tyr Asp Phe Trp Ser Gly Trp Asp Val Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3467 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 294 LC variable region <400> 3467 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3468 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 294 HC variable region <400> 3468 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3469 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 295 LC variable region <400> 3469 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3470 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 295 HC variable region <400> 3470 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3471 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 296 LC variable region <400> 3471 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3472 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 296 HC variable region <400> 3472 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Ala Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3473 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 297 LC variable region <400> 3473 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3474 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 297 HC variable region <400> 3474 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Gly Pro Phe Glu Arg Lys 20 25 30 Val Ile Ala Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 35 40 45 Gly Gly His Ala Pro Phe Val Arg Lys Pro Thr Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Ala Asp Asp Ser Thr Ala Thr Ala Phe 65 70 75 80 Met Glu Leu Ser Ser Leu Gly Tyr Gly Asp Thr Gly Val Tyr Tyr Cys 85 90 95 Ala Thr Lys Ala Val Thr Thr Tyr Ser Gly Phe Asp Asn Trp Gly Gln 100 105 110 Gly Thr Leu Val Phe Val Ser Thr 115 120 <210> 3475 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 298 LC variable region <400> 3475 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Ser 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu 35 40 45 Tyr Ala Ala Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3476 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 298 HC variable region <400> 3476 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Thr Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asp Ser Lys Asn Met 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Thr His Ser Arg Pro Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 3477 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 299 LC variable region <400> 3477 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3478 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 299 HC variable region <400> 3478 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Gly Pro Phe Glu Arg Lys 20 25 30 Val Ile Ala Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 35 40 45 Gly Gly His Ala Pro Phe Val Arg Lys Pro Thr Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Ala Asp Asp Ser Thr Ser Thr Ala Phe 65 70 75 80 Met Glu Leu Ser Thr Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Lys Ala Val Thr Thr Tyr Ser Gly Phe Asp Thr Trp Gly Gln 100 105 110 Gly Thr Leu Val Leu Val Ser Ala 115 120 <210> 3479 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 300 LC variable region <400> 3479 Glu Leu Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu 35 40 45 Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Ala Ala Val Tyr Tyr Cys Leu Gln Tyr Phe Thr Ile Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3480 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 300 HC variable region <400> 3480 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Thr Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Thr Phe Ser Thr Pro Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 3481 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 301 LC variable region <400> 3481 Glu Leu Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3482 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 301 HC variable region <400> 3482 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Arg Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ile Arg Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Lys Val Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Val Asn 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Gly Ser Thr Trp Tyr Gly Gly Asn Trp Phe Asp Pro Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3483 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> No. 302 LC variable region <400> 3483 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Ser Gly Asp Val Leu Ala Lys Lys Tyr Ala 20 25 30 Arg Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Ala Ala Asp Asn Asn Gly Val 85 90 95 Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 <210> 3484 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No. 302 HC variable region <400> 3484 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asp 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ala Thr Tyr Asp Ser Ser Gly Arg Pro Thr Gly Asp Tyr 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3485 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 303 LC variable region <400> 3485 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3486 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 303 HC variable region <400> 3486 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3487 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No. 304 LC variable region <400> 3487 Glu Leu Ala Leu Asn Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala His Lys Leu 35 40 45 Met Met Tyr Asp Val Ser Asn Arg Pro Ser Gly Ala Tyr Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Ala Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Ser His Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3488 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 304 HC variable region <400> 3488 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Ser Ser Tyr Ala 20 25 30 Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 35 40 45 Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Lys Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser Glu 100 105 110 Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3489 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 305 LC variable region <400> 3489 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3490 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> No. 305 HC variable region <400> 3490 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Arg Gly 20 25 30 Asp Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 50 55 60 Lys Ser Arg Val Thr Ile Ser Ala Asp Thr Ser Lys Asn Gln Phe Ser 65 70 75 80 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ala Tyr Tyr Cys 85 90 95 Ala Arg His Gly Thr Ser Gly Tyr Tyr Tyr Pro Asn Trp Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3491 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 306 LC variable region <400> 3491 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Ala Ser Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3492 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 306 HC variable region <400> 3492 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3493 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 307 LC variable region <400> 3493 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Thr Asp Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3494 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 307 HC variable region <400> 3494 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3495 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 308 LC variable region <400> 3495 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3496 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 308 HC variable region <400> 3496 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3497 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 309 LC variable region <400> 3497 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Arg Asp Asp Ser Leu 85 90 95 Asn Gly Ala Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3498 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 309 HC variable region <400> 3498 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3499 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 310 LC variable region <400> 3499 Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3500 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 310 HC variable region <400> 3500 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3501 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 311 LC variable region <400> 3501 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro Arg 85 90 95 Arg Val Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3502 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 311 HC variable region <400> 3502 Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3503 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 312 LC variable region <400> 3503 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Gln Val Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3504 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 312 HC variable region <400> 3504 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3505 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 313 LC variable region <400> 3505 Glu Leu Gly Gln Thr Gln Gln Leu Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3506 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 313 HC variable region <400> 3506 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr 100 105 110 Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3507 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 314 LC variable region <400> 3507 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3508 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 314 HC variable region <400> 3508 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 20 25 30 Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Ser Pro Ala Val Thr Thr Ala Gly Trp Phe Asp Pro Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3509 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 315 LC variable region <400> 3509 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn 20 25 30 Thr Val Asn Trp Tyr Gln His Leu Pro Gly Met Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Leu Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3510 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 315 HC variable region <400> 3510 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3511 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 316 LC variable region <400> 3511 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Gly Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3512 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 316 HC variable region <400> 3512 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Phe Tyr 20 25 30 Ala Ile Ser Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Lys Tyr Ala Gln Arg Phe 50 55 60 Gln Asp Arg Val Thr Phe Ile Ala Asp Asp Thr Ser Thr Ala Tyr Met 65 70 75 80 Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Gly Trp Ile Tyr Arg Gly Asn Trp Phe Asp Pro Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3513 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 317 LC variable region <400> 3513 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Trp Val Leu Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3514 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 317 HC variable region <400> 3514 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Thr Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Asn Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ser Ser His Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro 100 105 110 Arg Phe Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 115 120 125 Ser <210> 3515 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 318 LC variable region <400> 3515 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 85 90 95 Asn Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3516 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 318 HC variable region <400> 3516 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser 100 105 110 Glu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3517 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 319 LC variable region <400> 3517 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Leu Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3518 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 319 HC variable region <400> 3518 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser 100 105 110 Glu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3519 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 320 LC variable region <400> 3519 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3520 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 320 HC variable region <400> 3520 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Val Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3521 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 321 LC variable region <400> 3521 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Leu Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3522 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 321 HC variable region <400> 3522 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ile Ser Tyr 20 25 30 Trp Ile Val Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Thr Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Ile Tyr Asn Trp Phe Asp Ser Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3523 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 322 LC variable region <400> 3523 Glu Leu Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3524 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 322 HC variable region <400> 3524 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Ile Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ile Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Arg Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Pro Leu Thr Gly Thr Thr Leu Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3525 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 323 LC variable region <400> 3525 Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 35 40 45 Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 85 90 95 Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 3526 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 323 HC variable region <400> 3526 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr 100 105 110 Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3527 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 324 LC variable region <400> 3527 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3528 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 324 HC variable region <400> 3528 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Ser Asn Tyr 20 25 30 Pro Leu Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Gly Ile Ile Pro Ile Ile Gly Ala Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Phe 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Arg Gly Tyr Ser Gly Tyr Gly Ala Ala Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3529 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No. 325 LC variable region <400> 3529 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3530 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 325 HC variable region <400> 3530 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Gly Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Leu Tyr Tyr Tyr Asp Arg Ser Gly Tyr Pro Ile Ser Glu 100 105 110 Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 115 120 125 <210> 3531 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 326 LC variable region <400> 3531 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3532 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 326 HC variable region <400> 3532 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Ala Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3533 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 327 LC variable region <400> 3533 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Ala Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3534 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 327 HC variable region <400> 3534 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Arg Gly Ser Gly Tyr Ser Phe Thr Ser His 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3535 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 328 LC variable region <400> 3535 Glu Leu Val Val Thr Gln Glu Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 85 90 95 Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 <210> 3536 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 328 HC variable region <400> 3536 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Asn Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Tyr Cys Gly Asp Asp Cys Tyr Pro Val Val Gly Thr Pro 100 105 110 Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 115 120 125 Ser <210> 3537 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 329 LC variable region <400> 3537 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Gly Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3538 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 329 HC variable region <400> 3538 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr 100 105 110 Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3539 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 330 LC variable region <400> 3539 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Gln 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3540 <211> 130 <212> PRT <213> Artificial Sequence <220> <223> No. 330 HC variable region <400> 3540 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Ser 20 25 30 Ser Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 35 40 45 Glu Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro 50 55 60 Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 65 70 75 80 Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr 85 90 95 Tyr Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr 100 105 110 Ser Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 115 120 125 Ser Ser 130 <210> 3541 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 331 LC variable region <400> 3541 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3542 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 331 HC variable region <400> 3542 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Tyr Ser Ser Trp Tyr Gly Pro Arg Thr Trp Phe Asp 100 105 110 Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3543 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 332 LC variable region <400> 3543 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3544 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 332 HC variable region <400> 3544 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Phe Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 85 90 95 Cys Ala Arg Gln Glu Trp Leu Arg Gly Gly Phe Asp Asp Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3545 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 333 LC variable region <400> 3545 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 20 25 30 Tyr Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3546 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No. 333 HC variable region <400> 3546 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Arg Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 3547 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 334 LC variable region <400> 3547 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3548 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 334 HC variable region <400> 3548 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3549 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 335 LC variable region <400> 3549 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3550 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 335 HC variable region <400> 3550 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Gly Ile Pro Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Arg Gly Tyr Ser Gly Tyr Gly Ala Asn Trp Tyr Phe Asp 100 105 110 Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3551 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 336 LC variable region <400> 3551 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3552 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 336 HC variable region <400> 3552 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Ala Phe Thr Arg Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Leu Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Gly Ile Ala Val Ala Gly Thr Pro Ile Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Pro 115 120 <210> 3553 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 337 LC variable region <400> 3553 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asp 20 25 30 Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Thr Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Thr Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3554 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 337 HC variable region <400> 3554 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Tyr Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3555 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No. 338 LC variable region <400> 3555 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gln 100 105 110 <210> 3556 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 338 HC variable region <400> 3556 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Pro Gly Gly Ser Thr Phe Phe Ala Asp Ser Val Gln 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ser Tyr Asp Phe Leu Thr Asp Tyr Thr Asp Ala Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 3557 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 339 LC variable region <400> 3557 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Pro Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3558 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 339 HC variable region <400> 3558 Glu Val Gln Leu Leu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Gly Val Val Thr Ala Asp Trp Tyr Phe Asp Leu Trp Gly Arg 100 105 110 Gly Thr Leu Ala Thr Val Ser Ser 115 120 <210> 3559 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No. 340 LC variable region <400> 3559 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3560 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 340 HC variable region <400> 3560 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Thr Phe Ser Arg Tyr 20 25 30 Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Leu Leu Gly Thr Ala Asp Tyr Pro Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Thr Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Thr Leu Tyr Tyr Tyr Asp Arg Ser Gly Asn Ala Arg Thr Asp 100 105 110 Asp Tyr Phe Asp His Trp Ala Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3561 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 341 LC variable region <400> 3561 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3562 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 341 HC variable region <400> 3562 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Val Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3563 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 342 LC variable region <400> 3563 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3564 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 342 HC variable region <400> 3564 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3565 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 343 LC variable region <400> 3565 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3566 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 343 HC variable region <400> 3566 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Pro Gly Gly Ser Thr Phe Phe Ala Asp Ser Val Gln 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ser Tyr Asp Phe Leu Thr Asp Tyr Thr Asp Ala Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 3567 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 344 LC variable region <400> 3567 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3568 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 344 HC variable region <400> 3568 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Arg Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Glu Glu Leu Gly Pro Tyr Ser Asn Arg Trp Tyr Ser Ser Ser 100 105 110 Asp Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3569 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 345 LC variable region <400> 3569 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3570 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 345 HC variable region <400> 3570 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Ser Ser 20 25 30 Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Phe Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Asp His Ile Val Ser Pro Leu Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3571 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 346 LC variable region <400> 3571 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3572 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 346 HC variable region <400> 3572 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Pro Gly Gly Ser Thr Phe Phe Ala Asp Ser Val Gln 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ser Tyr Asp Phe Leu Thr Asp Tyr Thr Asp Ala Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 3573 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 347 LC variable region <400> 3573 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3574 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 347 HC variable region <400> 3574 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Tyr Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3575 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 348 LC variable region <400> 3575 Glu Leu Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Pro Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Ser His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Ile Leu Tyr Glu Val Ser Asp Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3576 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 348 HC variable region <400> 3576 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3577 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 349 LC variable region <400> 3577 Glu Leu Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3578 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 349 HC variable region <400> 3578 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Pro Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3579 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 350 LC variable region <400> 3579 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Ala Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3580 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 350 HC variable region <400> 3580 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ile Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3581 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 351 LC variable region <400> 3581 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 35 40 45 Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Arg 85 90 95 Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 3582 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 351 HC variable region <400> 3582 Glu Val Gln Leu Leu Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Thr Thr Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Ile Gly Ser Gly Asp Arg Pro Asp Ala Phe His Leu Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 3583 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 352 LC variable region <400> 3583 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Glu Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3584 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 352 HC variable region <400> 3584 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3585 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 353 LC variable region <400> 3585 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3586 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 353 HC variable region <400> 3586 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Gly Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3587 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 354 LC variable region <400> 3587 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Asn Arg Ser Asp Ile Gly Gly Tyr 20 25 30 Asn Ser Leu Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Ile Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Tyr Thr Ser Lys 85 90 95 Asn Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3588 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 354 HC variable region <400> 3588 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3589 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 355 LC variable region <400> 3589 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3590 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 355 HC variable region <400> 3590 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3591 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 356 LC variable region <400> 3591 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3592 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 356 HC variable region <400> 3592 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Ser Ser 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3593 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 357 LC variable region <400> 3593 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Ala Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3594 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 357 HC variable region <400> 3594 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3595 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 358 LC variable region <400> 3595 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3596 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 358 HC variable region <400> 3596 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Gly Pro Phe Glu Arg Lys 20 25 30 Val Ile Ala Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 35 40 45 Gly Gly His Ala Pro Phe Val Arg Lys Pro Thr Tyr Ala Arg Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Ala Asp Asp Ser Thr Ser Thr Ala Phe 65 70 75 80 Met Glu Phe Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Thr Lys Ala Val Thr Thr Tyr Ser Gly Phe Asp Asn Trp Gly Gln 100 105 110 Gly Thr Leu Val Phe Val Ser Ala 115 120 <210> 3597 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 359 LC variable region <400> 3597 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Asn Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Pro Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3598 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> No. 359 HC variable region <400> 3598 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Pro Thr Ser Arg Ser Thr Tyr Tyr Tyr Tyr Ser Gly Ser 100 105 110 Tyr Tyr Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3599 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 360 LC variable region <400> 3599 Glu Leu Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Thr Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Ser Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3600 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 360 HC variable region <400> 3600 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Met Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Asp Ser Ser Gly Tyr Tyr Pro Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3601 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 361 LC variable region <400> 3601 Glu Leu Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Arg Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3602 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 361 HC variable region <400> 3602 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3603 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 362 LC variable region <400> 3603 Glu Leu Gln Met Thr Gln Ser Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Ser Tyr Arg Pro Ser Gly Val Ser Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Arg 65 70 75 80 Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ala Leu 85 90 95 Arg Gly Pro Leu Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 3604 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No. 362 HC variable region <400> 3604 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Gly Ile Ser Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Ala Thr Thr Lys Phe Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Trp Gly Leu Arg Leu Phe Gly Glu Phe Ser Val Trp Phe 100 105 110 Asp Pro Trp Gly Leu Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3605 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 363 LC variable region <400> 3605 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Asp Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3606 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No. 363 HC variable region <400> 3606 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Gly Ser Tyr 20 25 30 Gly Ile Ser Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Ala Thr Thr Lys Phe Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Trp Gly Leu Arg Leu Phe Gly Glu Phe Ser Val Trp Phe 100 105 110 Asp Pro Trp Gly Leu Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3607 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 364 LC variable region <400> 3607 Glu Leu Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 3608 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 364 HC variable region <400> 3608 Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3609 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 365 LC variable region <400> 3609 Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 1 5 10 15 Thr Val Thr Leu Thr Cys Ser Ser Ser Thr Gly Ala Val Thr Arg Gly 20 25 30 His Phe Pro Asn Trp Leu Gln Gln Lys Pro Gly Gln Thr Pro Arg Ala 35 40 45 Leu Ile His Ser Thr Ser Asn Lys His Ser Trp Thr Pro Ala Arg Phe 50 55 60 Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Leu Ser Gly Val 65 70 75 80 Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Tyr Asp Ala Gly 85 90 95 Ala Pro Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3610 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 365 HC variable region <400> 3610 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Leu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Ser Cys Ser Gly Gly Ser Cys Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3611 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 366 LC variable region <400> 3611 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 85 90 95 Ser Gly Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3612 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No. 366 HC variable region <400> 3612 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Gly Ile Ser Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Ala Thr Thr Lys Phe Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Trp Gly Leu Arg Leu Phe Gly Glu Phe Ser Val Trp Phe 100 105 110 Asp Pro Trp Gly Leu Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3613 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No. 367 LC variable region <400> 3613 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Phe Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Ser Ser Leu 85 90 95 Ser Thr Pro Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3614 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 367 HC variable region <400> 3614 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Leu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Ser Cys Ser Gly Gly Ser Cys Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3615 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 368 LC variable region <400> 3615 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3616 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No. 368 HC variable region <400> 3616 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Arg Phe Ser Ser Asn 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Asn Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Met Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Leu Ala Tyr Phe His Pro Gln Arg Asn Gly Gly Tyr Glu Tyr 100 105 110 Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Pro 115 120 125 <210> 3617 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 369 LC variable region <400> 3617 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Ala Ser Lys Asp Ala Ala Ser Ala Tyr Leu Thr Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 85 90 95 Leu Arg Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3618 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No. 369 HC variable region <400> 3618 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Gln 20 25 30 Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Tyr Gly Gly Ser Thr Thr Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Pro Ser Gly Tyr Tyr Gly Asp Tyr Glu Gly Asp Ala Phe 100 105 110 Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 3619 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 370 LC variable region <400> 3619 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3620 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> No. 370 HC variable region <400> 3620 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Ile Pro Ile Phe Gly Thr Val Lys Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Leu Pro Gly Asp Ser Arg Asp Gly Tyr Asn Tyr Asp Ala 100 105 110 Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Leu 115 120 125 <210> 3621 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 371 LC variable region <400> 3621 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3622 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No. 371 HC variable region <400> 3622 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3623 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 372 LC variable region <400> 3623 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3624 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No. 372 HC variable region <400> 3624 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 3625 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 373 LC variable region <400> 3625 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3626 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 373 HC variable region <400> 3626 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Ile Tyr Asn Trp Phe Asp Ser Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3627 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 374 LC variable region <400> 3627 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Arg Asn Trp Pro Pro 85 90 95 Val Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3628 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 374 HC variable region <400> 3628 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Glu Gly Tyr Asp Ser Ser Gly Tyr Tyr Leu Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3629 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 375 LC variable region <400> 3629 Glu Leu Gly Gln Thr Gln Gln Leu Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3630 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 375 HC variable region <400> 3630 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr 100 105 110 Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3631 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 376 LC variable region <400> 3631 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Arg Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3632 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 376 HC variable region <400> 3632 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3633 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 377 LC variable region <400> 3633 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3634 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 377 HC variable region <400> 3634 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3635 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 378 LC variable region <400> 3635 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Lys Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3636 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 378 HC variable region <400> 3636 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Glu Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Pro 115 120 <210> 3637 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> No. 379 LC variable region <400> 3637 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Trp Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3638 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 379 HC variable region <400> 3638 Glu Val Gln Leu Leu Glu Ser Gly Gly Ser Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Arg Gly Gly Ser Tyr Leu Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3639 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 380 LC variable region <400> 3639 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Arg Asn Trp Pro Pro 85 90 95 Arg Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3640 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 380 HC variable region <400> 3640 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Glu Gly Tyr Asp Ser Ser Gly Tyr Tyr Leu Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3641 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 381 LC variable region <400> 3641 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3642 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 381 HC variable region <400> 3642 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3643 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 382 LC variable region <400> 3643 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Gly Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3644 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 382 HC variable region <400> 3644 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3645 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 383 LC variable region <400> 3645 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Lys Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3646 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 383 HC variable region <400> 3646 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Ser Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3647 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 384 LC variable region <400> 3647 Glu Leu Gln Met Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 3648 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 384 HC variable region <400> 3648 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3649 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 385 LC variable region <400> 3649 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3650 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 385 HC variable region <400> 3650 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Asp Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3651 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> No. 386 LC variable region <400> 3651 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Trp Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3652 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 386 HC variable region <400> 3652 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Glu Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3653 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> No. 387 LC variable region <400> 3653 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Trp Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3654 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 387 HC variable region <400> 3654 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Arg Gly Gly Ser Tyr Leu Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3655 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 388 LC variable region <400> 3655 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Asn Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3656 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 388 HC variable region <400> 3656 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Glu Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3657 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 389 LC variable region <400> 3657 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Met Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3658 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 389 HC variable region <400> 3658 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ile Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3659 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 390 LC variable region <400> 3659 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Arg Ser Asn Ile Gly Ile Asn 20 25 30 Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Leu Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Glu Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3660 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 390 HC variable region <400> 3660 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3661 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No. 391 LC variable region <400> 3661 Glu Leu Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Ala Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Gly Asp Tyr Phe Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Gly Thr Leu Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3662 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 391 HC variable region <400> 3662 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3663 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 392 LC variable region <400> 3663 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn 20 25 30 Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Val Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Thr Ser Leu 85 90 95 Ser Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3664 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 392 HC variable region <400> 3664 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3665 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 393 LC variable region <400> 3665 Glu Leu Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Thr Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3666 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> No. 393 HC variable region <400> 3666 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ala Ile Trp His Asp Gly Tyr Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Ser Lys Ala Ala Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Ile Val Ser Ser 115 <210> 3667 <211> 105 <212> PRT <213> Artificial Sequence <220> <223> No. 394 LC variable region <400> 3667 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 35 40 45 Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Phe 85 90 95 Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> 3668 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 394 HC variable region <400> 3668 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3669 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 395 LC variable region <400> 3669 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Thr Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Met Tyr Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3670 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 395 HC variable region <400> 3670 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Glu Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3671 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 396 LC variable region <400> 3671 Glu Leu Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Arg Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3672 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 396 HC variable region <400> 3672 Gln Ile Thr Leu Lys Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Gly Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser 100 105 110 Glu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3673 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 397 LC variable region <400> 3673 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3674 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 397 HC variable region <400> 3674 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Pro Arg Gly Tyr Ser Gly Tyr Gly Ser Asn Trp Tyr Phe Asp 100 105 110 Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3675 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 398 LC variable region <400> 3675 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe 20 25 30 Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Ala Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3676 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 398 HC variable region <400> 3676 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3677 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 399 LC variable region <400> 3677 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Thr Thr Gln Asn Ile Asn Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Val Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3678 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 399 HC variable region <400> 3678 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Pro Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 35 40 45 Ala Leu Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Thr Tyr Gly Ser Tyr Tyr Tyr Gly Met Asp Ala Trp Gly 100 105 110 Leu Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3679 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 400 LC variable region <400> 3679 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3680 <211> 115 <212> PRT <213> Artificial Sequence <220> <223> No. 400 HC variable region <400> 3680 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Tyr Ala Leu Asn Pro Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 3681 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 401 LC variable region <400> 3681 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3682 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 401 HC variable region <400> 3682 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3683 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 402 LC variable region <400> 3683 Glu Leu Val Val Thr Gln Pro Pro Pro Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3684 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 402 HC variable region <400> 3684 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3685 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 403 LC variable region <400> 3685 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Ser Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3686 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 403 HC variable region <400> 3686 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3687 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 404 LC variable region <400> 3687 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3688 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 404 HC variable region <400> 3688 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3689 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 405 LC variable region <400> 3689 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3690 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 405 HC variable region <400> 3690 Glu Val Gln Leu Met Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3691 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 406 LC variable region <400> 3691 Glu Leu Val Met Thr Gln Ser Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 3692 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 406 HC variable region <400> 3692 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Ser Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3693 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 407 LC variable region <400> 3693 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3694 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 407 HC variable region <400> 3694 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Arg Tyr Tyr Asp Phe Trp Ser Gly Trp Asp Val Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3695 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 408 LC variable region <400> 3695 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Ser Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3696 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 408 HC variable region <400> 3696 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3697 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 409 LC variable region <400> 3697 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Val Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Arg Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Thr Ser Leu 85 90 95 Ser Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3698 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 409 HC variable region <400> 3698 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3699 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 410 LC variable region <400> 3699 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3700 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 410 HC variable region <400> 3700 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3701 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 411 LC variable region <400> 3701 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3702 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 411 HC variable region <400> 3702 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Asp His Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3703 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 412 LC variable region <400> 3703 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Thr Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3704 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 412 HC variable region <400> 3704 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3705 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> No. 413 LC variable region <400> 3705 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Ser Gly Asp Val Leu Ala Lys Lys Tyr Ala 20 25 30 Arg Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Ala Ala Asp Asn Asn Gly Val 85 90 95 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> 3706 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No. 413 HC variable region <400> 3706 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asp 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ala Thr Tyr Asp Ser Ser Gly Arg Pro Thr Gly Asp Tyr 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3707 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 414 LC variable region <400> 3707 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Arg Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3708 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 414 HC variable region <400> 3708 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Gly Ser Gly Tyr Tyr Gln Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3709 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 415 LC variable region <400> 3709 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3710 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 415 HC variable region <400> 3710 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Tyr Ser Ser Trp Tyr Gly Pro Arg Thr Trp Phe Asp 100 105 110 Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3711 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 416 LC variable region <400> 3711 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Arg Ser Asn Trp Pro Pro 85 90 95 Ala Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3712 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 416 HC variable region <400> 3712 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Ser Gly Tyr Asp Ser Ser Gly Tyr Tyr Ser Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3713 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 417 LC variable region <400> 3713 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3714 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 417 HC variable region <400> 3714 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr His Cys 85 90 95 Val Arg Val Gly Thr Tyr Asp Ser Ser Gly Tyr Ser Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3715 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 418 LC variable region <400> 3715 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3716 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 418 HC variable region <400> 3716 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3717 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 419 LC variable region <400> 3717 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Asp Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Ala Pro Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3718 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 419 HC variable region <400> 3718 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Pro Arg Gly Gly Asn Tyr Arg Gly Ala Leu Asp Ile Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 3719 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 420 LC variable region <400> 3719 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Val Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Pro 85 90 95 Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3720 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 420 HC variable region <400> 3720 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ala Met Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Pro Thr Gly Trp Tyr Ser Gly Tyr Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3721 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 421 LC variable region <400> 3721 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 20 25 30 Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3722 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 421 HC variable region <400> 3722 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Met Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Asp Ser Ser Gly Tyr Tyr Pro Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3723 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 422 LC variable region <400> 3723 Glu Leu Lys Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3724 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 422 HC variable region <400> 3724 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 20 25 30 Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Ser Pro Ala Val Thr Thr Ala Gly Trp Phe Asp Pro Cys Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3725 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 423 LC variable region <400> 3725 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Asp 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Arg Gly Asp Ile Gly Ala Tyr 20 25 30 Asp Gly Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 35 40 45 Ile Ile Tyr Ala Val Thr Gln Arg Pro Ser Gly Ile Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3726 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 423 HC variable region <400> 3726 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Pro Glu Leu 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ile Ser Pro Ala Ile Ile Arg Val Asp Trp Phe Asp Pro Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3727 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 424 LC variable region <400> 3727 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Asp 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Arg Gly Asp Ile Gly Ala Tyr 20 25 30 Asp Gly Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 35 40 45 Ile Ile Tyr Ala Val Thr Gln Arg Pro Ser Gly Ile Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3728 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 424 HC variable region <400> 3728 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3729 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 425 LC variable region <400> 3729 Glu Leu Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Ser Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 3730 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 425 HC variable region <400> 3730 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3731 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 426 LC variable region <400> 3731 Glu Leu Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Lys Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Pro Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 3732 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 426 HC variable region <400> 3732 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3733 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 427 LC variable region <400> 3733 Glu Leu Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Asn Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3734 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 427 HC variable region <400> 3734 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Phe Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3735 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 428 LC variable region <400> 3735 Glu Leu Gln Met Thr Gln Ser Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Thr Asp Ile Gly Arg Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Tyr Ala Phe Gly Thr Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 3736 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> No. 428 HC variable region <400> 3736 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Pro Glu Val 20 25 30 Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Gly Pro Val Leu Gly Leu Ser Lys Trp Leu Glu Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3737 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 429 LC variable region <400> 3737 Glu Leu Gln Met Thr Gln Ser Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 3738 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> No. 429 HC variable region <400> 3738 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Pro Glu Val 20 25 30 Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Gly Pro Val Leu Gly Leu Ser Lys Trp Leu Glu Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3739 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 430 LC variable region <400> 3739 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3740 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 430 HC variable region <400> 3740 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3741 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 431 LC variable region <400> 3741 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Glu Ala Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3742 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 431 HC variable region <400> 3742 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3743 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 432 LC variable region <400> 3743 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3744 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 432 HC variable region <400> 3744 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3745 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 433 LC variable region <400> 3745 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3746 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 433 HC variable region <400> 3746 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3747 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 434 LC variable region <400> 3747 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3748 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 434 HC variable region <400> 3748 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3749 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 435 LC variable region <400> 3749 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3750 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 435 HC variable region <400> 3750 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Tyr 20 25 30 Val Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Ile Pro Val Phe Gly Ile Ala Asp Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Gly Leu Phe Asp Trp Leu Leu Pro Arg Ser Arg His Arg 100 105 110 Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3751 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 436 LC variable region <400> 3751 Glu Leu Gly Gln Thr Gln Gln Leu Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3752 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> No. 436 HC variable region <400> 3752 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Pro Thr Ser Arg Ser Thr Tyr Tyr Tyr Tyr Ser Gly Ser 100 105 110 Tyr Tyr Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3753 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 437 LC variable region <400> 3753 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Gly Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 3754 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> No. 437 HC variable region <400> 3754 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Pro Thr Ser Arg Ser Thr Tyr Tyr Tyr Tyr Ser Gly Ser 100 105 110 Tyr Tyr Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3755 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 438 LC variable region <400> 3755 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Arg Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3756 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No. 438 HC variable region <400> 3756 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 20 25 30 Pro Ile His Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Arg Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Asn Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Asp Leu Thr Thr Val Thr Asn Pro Leu Asn Tyr Tyr Tyr Tyr 100 105 110 Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3757 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 439 LC variable region <400> 3757 Glu Leu Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Val Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Ser Gln Arg Pro Ser Gly Val Pro Ala Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Val Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Met Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3758 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No. 439 HC variable region <400> 3758 Gln Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Gly Thr Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Gly Tyr Asn Glu Asn Ser Thr His Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ala Leu Arg Tyr Asp Ile Leu Thr Gly Phe Thr Gly Phe 100 105 110 Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 115 120 125 <210> 3759 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 440 LC variable region <400> 3759 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3760 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 440 HC variable region <400> 3760 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Asp Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Lys Val Arg Tyr Tyr Asp Phe Trp Ser Gly Trp Asp Val Met Asp 100 105 110 Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3761 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 441 LC variable region <400> 3761 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3762 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No. 441 HC variable region <400> 3762 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Thr Tyr Tyr Tyr Asp Ser Ser Gly Pro Leu Asn Trp Phe 100 105 110 Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3763 <211> 103 <212> PRT <213> Artificial Sequence <220> <223> No. 442 LC variable region <400> 3763 Glu Leu Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Ser Leu Ser Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Leu Thr Phe Gly Gly 85 90 95 Gly Thr Lys Val Glu Ile Lys 100 <210> 3764 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> No. 442 HC variable region <400> 3764 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Phe Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Thr Gly Lys Pro Tyr Tyr Cys Thr Gly Ser Thr Cys Tyr Gln Pro 100 105 110 Leu Gly Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3765 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 443 LC variable region <400> 3765 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3766 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 443 HC variable region <400> 3766 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3767 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 444 LC variable region <400> 3767 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asn Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Asp Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Gly Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3768 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 444 HC variable region <400> 3768 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Pro Glu Leu 20 25 30 Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Asp Pro Glu Asn Gly Glu Thr Ile His Ala Gln Arg Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Ser Thr Pro Met Ile Arg Ala Ser Trp Phe Asp Pro Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3769 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 445 LC variable region <400> 3769 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Phe Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Gln Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3770 <211> 115 <212> PRT <213> Artificial Sequence <220> <223> No. 445 HC variable region <400> 3770 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Tyr Ser Gly Asn Phe Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 3771 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 446 LC variable region <400> 3771 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3772 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 446 HC variable region <400> 3772 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ile Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3773 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 447 LC variable region <400> 3773 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Arg Asn 20 25 30 Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Thr Arg Ala Thr Asp Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3774 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 447 HC variable region <400> 3774 Gln Ile Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3775 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 448 LC variable region <400> 3775 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Thr Ser Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3776 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 448 HC variable region <400> 3776 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3777 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 449 LC variable region <400> 3777 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3778 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 449 HC variable region <400> 3778 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Gly 20 25 30 Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3779 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 450 LC variable region <400> 3779 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3780 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 450 HC variable region <400> 3780 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3781 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 451 LC variable region <400> 3781 Glu Leu Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Tyr 20 25 30 Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr His Thr Ser Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3782 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 451 HC variable region <400> 3782 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3783 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 452 LC variable region <400> 3783 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3784 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 452 HC variable region <400> 3784 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3785 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 453 LC variable region <400> 3785 Glu Leu Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Val Gly Asp Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Thr Asn Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Gly 85 90 95 Ser Thr Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3786 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 453 HC variable region <400> 3786 Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3787 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 454 LC variable region <400> 3787 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3788 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 454 HC variable region <400> 3788 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3789 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 455 LC variable region <400> 3789 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3790 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 455 HC variable region <400> 3790 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3791 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 456 LC variable region <400> 3791 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Gln 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3792 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 456 HC variable region <400> 3792 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3793 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 457 LC variable region <400> 3793 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Met 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3794 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 457 HC variable region <400> 3794 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3795 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 458 LC variable region <400> 3795 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Gly Ser Ser Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3796 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 458 HC variable region <400> 3796 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3797 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 459 LC variable region <400> 3797 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 3798 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No. 459 HC variable region <400> 3798 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 3799 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 460 LC variable region <400> 3799 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3800 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No. 460 HC variable region <400> 3800 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 3801 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 461 LC variable region <400> 3801 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Gly Val Thr Ile Ser Cys Ser Gly Leu Thr Ser Asn Ile Gly Ser Asn 20 25 30 Phe Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Gly Glu Tyr Phe Cys Ala Ala Trp Asp Asp Thr Leu 85 90 95 Val Gly Arg Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3802 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No. 461 HC variable region <400> 3802 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Pro Ser 130 <210> 3803 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 462 LC variable region <400> 3803 Glu Leu Val Val Thr Gln Glu Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Pro Val Phe Gly Gly Thr Gln Leu Thr Val Leu 100 105 <210> 3804 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 462 HC variable region <400> 3804 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Arg Gly Ser Gly Tyr Ser Phe Thr Ser His 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3805 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 463 LC variable region <400> 3805 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3806 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 463 HC variable region <400> 3806 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Arg Gly Ser Gly Tyr Ser Phe Thr Ser His 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3807 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 464 LC variable region <400> 3807 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Ser Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3808 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 464 HC variable region <400> 3808 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Ser Ser Gly Tyr Ser Phe Ile Ser Tyr 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Leu Tyr Asn Trp Phe Asp Phe Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3809 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 465 LC variable region <400> 3809 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly His Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3810 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 465 HC variable region <400> 3810 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ile Ser Tyr 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Leu Tyr Asn Trp Phe Asp Phe Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3811 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 466 LC variable region <400> 3811 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3812 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 466 HC variable region <400> 3812 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Arg Gly Ser Gly Tyr Ser Phe Thr Ser His 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3813 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 467 LC variable region <400> 3813 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3814 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 467 HC variable region <400> 3814 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Tyr Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3815 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 468 LC variable region <400> 3815 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Ser 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu 35 40 45 Tyr Ala Ala Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3816 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 468 HC variable region <400> 3816 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Tyr Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3817 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 469 LC variable region <400> 3817 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Ser Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3818 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 469 HC variable region <400> 3818 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asn 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Thr Tyr Gly Ser Gly Ser Tyr Ser Asp Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3819 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 470 LC variable region <400> 3819 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3820 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 470 HC variable region <400> 3820 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asn 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Thr Tyr Gly Ser Gly Ser Tyr Ser Asp Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3821 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 471 LC variable region <400> 3821 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Arg Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3822 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 471 HC variable region <400> 3822 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Asn Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Tyr Cys Gly Asp Asp Cys Tyr Pro Val Val Gly Thr Pro 100 105 110 Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 115 120 125 Ser <210> 3823 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 472 LC variable region <400> 3823 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3824 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 472 HC variable region <400> 3824 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Asn Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Tyr Cys Gly Asp Asp Cys Tyr Pro Val Val Gly Thr Pro 100 105 110 Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 115 120 125 Ser <210> 3825 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 473 LC variable region <400> 3825 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Met Gln Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3826 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 473 HC variable region <400> 3826 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Asn Tyr 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Tyr Asp Ser Asp Thr Arg Lys Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Met Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Thr Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Ser Gly Thr Tyr Gly Trp Ile Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3827 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 474 LC variable region <400> 3827 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3828 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 474 HC variable region <400> 3828 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Phe Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 85 90 95 Cys Ala Arg Gln Glu Trp Leu Arg Gly Gly Phe Asp Asp Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3829 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 475 LC variable region <400> 3829 Glu Leu Gln Met Thr Gln Ser Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Val Gly Ser Asn 20 25 30 Ile Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Ala Trp Val Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 3830 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 475 HC variable region <400> 3830 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Asn His 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Tyr Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Asn Pro Thr Val Thr Asn Trp Phe Asp Ser Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3831 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> No. 476 LC variable region <400> 3831 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Pro Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val 100 105 110 Leu <210> 3832 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 476 HC variable region <400> 3832 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Phe Phe Gly Thr Ser Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Val Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gln Phe Ser Asp Ser Ser Gly Tyr Gln His Pro Tyr Tyr 100 105 110 Asp Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 115 120 125 Ser <210> 3833 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 477 LC variable region <400> 3833 Glu Leu Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3834 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No. 477 HC variable region <400> 3834 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr His 20 25 30 Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Pro Ala Asp Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Leu Ser Leu Gly Phe Cys Ser Ala Gly Ser Cys Tyr Asp 100 105 110 Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3835 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 478 LC variable region <400> 3835 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asp Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3836 <211> 133 <212> PRT <213> Artificial Sequence <220> <223> No. 478 HC variable region <400> 3836 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 20 25 30 Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Tyr Pro Gly Tyr Tyr Asp Ile Leu Thr Gly Gln Ile 100 105 110 Gly Thr Gly Glu Arg Asn Ala Met Asp Val Trp Gly Gln Gly Thr Thr 115 120 125 Val Thr Val Ser Ser 130 <210> 3837 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 479 LC variable region <400> 3837 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3838 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 479 HC variable region <400> 3838 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Ser Asn Tyr 20 25 30 Pro Leu Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Gly Ile Ile Pro Ile Ile Gly Ala Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Phe 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Arg Gly Tyr Ser Gly Tyr Gly Ala Ala Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3839 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 480 LC variable region <400> 3839 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 85 90 95 Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 3840 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 480 HC variable region <400> 3840 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Phe Ile Asn Pro Ser Asp Val Thr Thr Tyr Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Ser Arg Ile Ala Pro Thr Glu Asp Phe Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Ser Leu Val Thr Val Ser Ser 115 120 <210> 3841 <211> 1273 <212> PRT <213> Artificial Sequence <220> <223> SARS-CoV-2 virus spike protein sequence <400> 3841 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 1010 1015 1020 Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 1025 1030 1035 1040 Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 1045 1050 1055 Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 1060 1065 1070 Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 1075 1080 1085 Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 1090 1095 1100 Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 1105 1110 1115 1120 Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 1125 1130 1135 Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 1140 1145 1150 Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 1155 1160 1165 Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 1170 1175 1180 Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 1185 1190 1195 1200 Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 1205 1210 1215 Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 1220 1225 1230 Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 1235 1240 1245 Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 1250 1255 1260 Leu Lys Gly Val Lys Leu His Tyr Thr 1265 1270 <210> 3842 <211> 1273 <212> PRT <213> Artificial Sequence <220> <223> SARS-CoV-2 virus spike protein RBD sequence <400> 1 Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 1 5 10 15 Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 20 25 30 Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 35 40 45 Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 50 55 60 Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 65 70 75 80 Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 85 90 95 Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 100 105 110 Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 115 120 125 Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 130 135 140 Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 145 150 155 160 Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 165 170 175 Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 180 185 190 Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 195 200 205 Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 210 215 220 <110> CELLTRION, INC. <120> STABLE PHARMACEUTICAL FORMULATION <130> CPD2021059KR <150> KR 10-2020-0100805 <151> 2020-08-11 <160> 3842 <170> KoPatentIn 3.0 <210> 1 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 1 LC CDR1 <400> 1 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 1 LC CDR2 <400> 2 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 3 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 1 LC CDR3 <400> 3 Gln Gln Ser Tyr Ser Thr Pro Phe Thr 1 5 <210> 4 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 1 HC CDR1 <400> 4 Asp Tyr Ala Met His 1 5 <210> 5 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 1 HC CDR2 <400> 5 Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 6 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 1 HC CDR3 <400> 6 Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu Asp Ala 1 5 10 15 Phe Asp Ile <210> 7 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 2 LC CDR1 <400> 7 Arg Ala Ser Gln Ser Ile Ser Thr Tyr Leu Asn 1 5 10 <210> 8 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 2 LC CDR2 <400> 8 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 9 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 2 LC CDR3 <400> 9 Gln Gln Ser Tyr Ser Ile Pro His Thr 1 5 <210> 10 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 2 HC CDR1 <400> 10 Asp Tyr Ala Met His 1 5 <210> 11 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 2 HC CDR2 <400> 11 Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 12 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 2 HC CDR3 <400> 12 Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu Asp Ala 1 5 10 15 Phe Asp Ile <210> 13 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 3 LC CDR1 <400> 13 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 14 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 3 LC CDR2 <400> 14 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 15 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 3 LC CDR3 <400> 15 Gln Gln Tyr Asp Asn Leu Pro Ile Thr 1 5 <210> 16 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 3 HC CDR1 <400> 16 Ser Tyr Ala Met Ser 1 5 <210> 17 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 3 HC CDR2 <400> 17 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 18 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 3 HC CDR3 <400> 18 Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr Ser Trp 1 5 10 15 Phe Asp Pro <210> 19 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 4 LC CDR1 <400> 19 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 20 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 4 LC CDR2 <400> 20 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 21 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 4 LC CDR3 <400> 21 Gln Gln Tyr Asp Asp Leu Pro Ile Thr 1 5 <210> 22 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 4 HC CDR1 <400> 22 Ser Tyr Ala Met Ser 1 5 <210> 23 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 4 HC CDR2 <400> 23 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 24 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 4 HC CDR3 <400> 24 Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr Ser Trp 1 5 10 15 Phe Asp Pro <210> 25 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 5 LC CDR1 <400> 25 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 26 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 5 LC CDR2 <400> 26 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 27 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 5 LC CDR3 <400> 27 Gln Gln Tyr Asp Asn Leu Pro Ile Thr 1 5 <210> 28 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 5 HC CDR1 <400> 28 Ser Tyr Ala Met Ser 1 5 <210> 29 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 5 HC CDR2 <400> 29 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 30 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 5 HC CDR3 <400> 30 Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr Ser Trp 1 5 10 15 Phe Asp Pro <210> 31 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 6 LC CDR1 <400> 31 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 32 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 6 LC CDR2 <400> 32 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 33 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 6 LC CDR3 <400> 33 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 34 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 6 HC CDR1 <400> 34 Ser Tyr Ala Ile Ser 1 5 <210> 35 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 6 HC CDR2 <400> 35 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 36 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 6 HC CDR3 <400> 36 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 37 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 7 LC CDR1 <400> 37 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 38 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 7 LC CDR2 <400> 38 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 39 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 7 LC CDR3 <400> 39 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 40 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 7 HC CDR1 <400> 40 Ser Tyr Ala Ile Ser 1 5 <210> 41 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 7 HC CDR2 <400> 41 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 42 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 7 HC CDR3 <400> 42 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 43 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC CDR1 <400> 43 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 44 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC CDR2 <400> 44 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 45 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC CDR3 <400> 45 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 46 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC CDR1 <400> 46 Ser Tyr Ala Ile Ser 1 5 <210> 47 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC CDR2 <400> 47 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 48 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC CDR3 <400> 48 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 49 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 9 LC CDR1 <400> 49 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 50 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 9 LC CDR2 <400> 50 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 51 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 9 LC CDR3 <400> 51 Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 1 5 10 <210> 52 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 9 HC CDR1 <400> 52 Ser Tyr Ala Ile Ser 1 5 <210> 53 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 9 HC CDR2 <400> 53 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 54 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 9 HC CDR3 <400> 54 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 55 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC CDR1 <400> 55 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 56 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC CDR2 <400> 56 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 57 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC CDR3 <400> 57 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 58 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC CDR1 <400> 58 Ser Tyr Ala Ile Ser 1 5 <210> 59 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC CDR2 <400> 59 Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 60 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC CDR3 <400> 60 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 61 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 11 LC CDR1 <400> 61 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 62 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 11 LC CDR2 <400> 62 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 63 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 11 LC CDR3 <400> 63 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 64 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 11 HC CDR1 <400> 64 Ser Tyr Ala Ile Ser 1 5 <210> 65 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 11 HC CDR2 <400> 65 Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 66 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 11 HC CDR3 <400> 66 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 67 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.12 LC CDR1 <400> 67 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 68 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 12 LC CDR2 <400> 68 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 69 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 12 LC CDR3 <400> 69 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 70 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 12 HC CDR1 <400> 70 Ser Tyr Ala Ile Ser 1 5 <210> 71 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 12 HC CDR2 <400> 71 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 72 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.12 HC CDR3 <400> 72 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 73 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 13 LC CDR1 <400> 73 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Tyr 1 5 10 <210> 74 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 13 LC CDR2 <400> 74 Gly Asn Tyr Gln Arg Pro Ser 1 5 <210> 75 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 13 LC CDR3 <400> 75 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 76 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 13 HC CDR1 <400> 76 Ser Tyr Ala Ile Ser 1 5 <210> 77 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 13 HC CDR2 <400> 77 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 78 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 13 HC CDR3 <400> 78 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 79 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 14 LC CDR1 <400> 79 Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn Tyr Val His 1 5 10 <210> 80 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 14 LC CDR2 <400> 80 Ser Asn Asp Gln Arg Pro Ser 1 5 <210> 81 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 14 LC CDR3 <400> 81 Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 1 5 10 <210> 82 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 14 HC CDR1 <400> 82 Ser Tyr Ala Ile Ser 1 5 <210> 83 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 14 HC CDR2 <400> 83 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 84 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 14 HC CDR3 <400> 84 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 85 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.15 LC CDR1 <400> 85 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 86 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.15 LC CDR2 <400> 86 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 87 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 15 LC CDR3 <400> 87 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 88 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 15 HC CDR1 <400> 88 Ser Tyr Ala Ile Ser 1 5 <210> 89 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.15 HC CDR2 <400> 89 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 90 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.15 HC CDR3 <400> 90 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 91 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC CDR1 <400> 91 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 92 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC CDR2 <400> 92 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 93 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC CDR3 <400> 93 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 94 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC CDR1 <400> 94 Ser Tyr Ala Ile Ser 1 5 <210> 95 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC CDR2 <400> 95 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 96 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC CDR3 <400> 96 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 97 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC CDR1 <400> 97 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 98 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC CDR2 <400> 98 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 99 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC CDR3 <400> 99 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 100 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC CDR1 <400> 100 Ser Tyr Ala Ile Ser 1 5 <210> 101 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC CDR2 <400> 101 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 102 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC CDR3 <400> 102 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 103 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 18 LC CDR1 <400> 103 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 104 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 18 LC CDR2 <400> 104 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 105 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.18 LC CDR3 <400> 105 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Lys Val 1 5 10 <210> 106 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 18 HC CDR1 <400> 106 Ser Tyr Ala Ile Ser 1 5 <210> 107 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 18 HC CDR2 <400> 107 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 108 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 18 HC CDR3 <400> 108 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 109 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC CDR1 <400> 109 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 110 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC CDR2 <400> 110 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 111 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC CDR3 <400> 111 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 112 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 19 HC CDR1 <400> 112 Ser Tyr Ala Ile Ser 1 5 <210> 113 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 19 HC CDR2 <400> 113 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 114 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 19 HC CDR3 <400> 114 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 115 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 20 LC CDR1 <400> 115 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 116 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 20 LC CDR2 <400> 116 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 117 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 20 LC CDR3 <400> 117 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 118 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 20 HC CDR1 <400> 118 Ser Tyr Ala Ile Ser 1 5 <210> 119 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 20 HC CDR2 <400> 119 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 120 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 20 HC CDR3 <400> 120 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 121 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC CDR1 <400> 121 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 122 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC CDR2 <400> 122 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 123 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC CDR3 <400> 123 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 124 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC CDR1 <400> 124 Ser Tyr Ala Ile Ser 1 5 <210> 125 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC CDR2 <400> 125 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 126 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC CDR3 <400> 126 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 127 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 22 LC CDR1 <400> 127 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 128 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 22 LC CDR2 <400> 128 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 129 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.22 LC CDR3 <400> 129 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 130 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.22 HC CDR1 <400> 130 Ser Tyr Ala Ile Ser 1 5 <210> 131 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 22 HC CDR2 <400> 131 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 132 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 22 HC CDR3 <400> 132 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 133 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC CDR1 <400> 133 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 134 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC CDR2 <400> 134 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 135 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC CDR3 <400> 135 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 136 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 23 HC CDR1 <400> 136 Ser Tyr Ala Ile Ser 1 5 <210> 137 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.23 HC CDR2 <400> 137 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 138 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.23 HC CDR3 <400> 138 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 139 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 24 LC CDR1 <400> 139 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 140 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 24 LC CDR2 <400> 140 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 141 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 24 LC CDR3 <400> 141 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 142 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 24 HC CDR1 <400> 142 Ser Tyr Ala Ile Ser 1 5 <210> 143 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 24 HC CDR2 <400> 143 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 144 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 24 HC CDR3 <400> 144 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 145 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC CDR1 <400> 145 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 146 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC CDR2 <400> 146 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 147 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC CDR3 <400> 147 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 148 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC CDR1 <400> 148 Ser Tyr Ala Ile Ser 1 5 <210> 149 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC CDR2 <400> 149 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 150 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC CDR3 <400> 150 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 151 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC CDR1 <400> 151 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 152 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC CDR2 <400> 152 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 153 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC CDR3 <400> 153 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 154 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC CDR1 <400> 154 Ser Tyr Ala Ile Ser 1 5 <210> 155 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC CDR2 <400> 155 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 156 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC CDR3 <400> 156 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 157 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC CDR1 <400> 157 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 158 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC CDR2 <400> 158 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 159 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC CDR3 <400> 159 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 160 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC CDR1 <400> 160 Ser Tyr Ala Ile Ser 1 5 <210> 161 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC CDR2 <400> 161 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 162 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC CDR3 <400> 162 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 163 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC CDR1 <400> 163 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 164 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC CDR2 <400> 164 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 165 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC CDR3 <400> 165 Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 1 5 10 <210> 166 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC CDR1 <400> 166 Ser Tyr Ala Ile Ser 1 5 <210> 167 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC CDR2 <400> 167 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 168 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC CDR3 <400> 168 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 169 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC CDR1 <400> 169 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 170 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC CDR2 <400> 170 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 171 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC CDR3 <400> 171 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 172 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC CDR1 <400> 172 Ser Tyr Ala Ile Ser 1 5 <210> 173 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC CDR2 <400> 173 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 174 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC CDR3 <400> 174 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 175 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 30 LC CDR1 <400> 175 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 176 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 30 LC CDR2 <400> 176 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 177 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 30 LC CDR3 <400> 177 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 178 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 30 HC CDR1 <400> 178 Ser Tyr Ala Ile Ser 1 5 <210> 179 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 30 HC CDR2 <400> 179 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 180 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 30 HC CDR3 <400> 180 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 181 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 31 LC CDR1 <400> 181 Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn Tyr Val His 1 5 10 <210> 182 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 31 LC CDR2 <400> 182 Ser Asn Asp Gln Arg Pro Ser 1 5 <210> 183 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 31 LC CDR3 <400> 183 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 184 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 31 HC CDR1 <400> 184 Ser Tyr Ala Ile Ser 1 5 <210> 185 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 31 HC CDR2 <400> 185 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 186 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 31 HC CDR3 <400> 186 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 187 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC CDR1 <400> 187 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 188 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC CDR2 <400> 188 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 189 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC CDR3 <400> 189 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 190 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC CDR1 <400> 190 Ser Tyr Ala Ile Ser 1 5 <210> 191 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC CDR2 <400> 191 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 192 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC CDR3 <400> 192 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 193 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC CDR1 <400> 193 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 194 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC CDR2 <400> 194 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 195 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC CDR3 <400> 195 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 196 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC CDR1 <400> 196 Ser Tyr Ala Ile Ser 1 5 <210> 197 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC CDR2 <400> 197 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 198 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC CDR3 <400> 198 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 199 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC CDR1 <400> 199 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 200 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC CDR2 <400> 200 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 201 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC CDR3 <400> 201 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 202 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC CDR1 <400> 202 Ser Tyr Ala Ile Ser 1 5 <210> 203 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC CDR2 <400> 203 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 204 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC CDR3 <400> 204 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 205 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC CDR1 <400> 205 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 206 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC CDR2 <400> 206 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 207 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC CDR3 <400> 207 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 208 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC CDR1 <400> 208 Ser Tyr Ala Ile Ser 1 5 <210> 209 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC CDR2 <400> 209 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 210 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC CDR3 <400> 210 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 211 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC CDR1 <400> 211 Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 212 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC CDR2 <400> 212 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 213 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC CDR3 <400> 213 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 214 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC CDR1 <400> 214 Ser Tyr Ala Ile Ser 1 5 <210> 215 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC CDR2 <400> 215 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 216 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC CDR3 <400> 216 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 217 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC CDR1 <400> 217 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 218 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC CDR2 <400> 218 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 219 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC CDR3 <400> 219 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 220 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC CDR1 <400> 220 Ser Tyr Ala Ile Ser 1 5 <210> 221 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC CDR2 <400> 221 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 222 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC CDR3 <400> 222 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 223 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC CDR1 <400> 223 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 224 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC CDR2 <400> 224 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 225 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC CDR3 <400> 225 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 226 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 38 HC CDR1 <400> 226 Ser Tyr Ala Ile Ser 1 5 <210> 227 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.38 HC CDR2 <400> 227 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 228 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.38 HC CDR3 <400> 228 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 229 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC CDR1 <400> 229 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 230 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC CDR2 <400> 230 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 231 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC CDR3 <400> 231 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 232 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC CDR1 <400> 232 Ser Tyr Ala Ile Ser 1 5 <210> 233 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC CDR2 <400> 233 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 234 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC CDR3 <400> 234 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 235 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 40 LC CDR1 <400> 235 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 236 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.40 LC CDR2 <400> 236 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 237 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.40 LC CDR3 <400> 237 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 238 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 40 HC CDR1 <400> 238 Ser Tyr Ala Ile Ser 1 5 <210> 239 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 40 HC CDR2 <400> 239 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 240 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 40 HC CDR3 <400> 240 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 241 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC CDR1 <400> 241 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 242 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC CDR2 <400> 242 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 243 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC CDR3 <400> 243 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 244 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC CDR1 <400> 244 Ser Tyr Ala Ile Ser 1 5 <210> 245 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC CDR2 <400> 245 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 246 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC CDR3 <400> 246 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 247 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC CDR1 <400> 247 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 248 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC CDR2 <400> 248 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 249 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC CDR3 <400> 249 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 250 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC CDR1 <400> 250 Ser Tyr Ala Ile Ser 1 5 <210> 251 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC CDR2 <400> 251 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 252 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC CDR3 <400> 252 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 253 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC CDR1 <400> 253 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 254 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC CDR2 <400> 254 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 255 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC CDR3 <400> 255 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 256 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC CDR1 <400> 256 Ser Tyr Ala Ile Ser 1 5 <210> 257 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC CDR2 <400> 257 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 258 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC CDR3 <400> 258 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 259 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC CDR1 <400> 259 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 260 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC CDR2 <400> 260 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 261 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC CDR3 <400> 261 Gln Gln Tyr Val Thr Thr Pro Tyr Thr 1 5 <210> 262 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC CDR1 <400> 262 Arg Ser Ser Tyr Tyr Trp Gly 1 5 <210> 263 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC CDR2 <400> 263 Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 264 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC CDR3 <400> 264 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 265 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC CDR1 <400> 265 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 266 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC CDR2 <400> 266 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 267 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC CDR3 <400> 267 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 268 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC CDR1 <400> 268 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 269 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC CDR2 <400> 269 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 270 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC CDR3 <400> 270 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 271 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC CDR1 <400> 271 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 272 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC CDR2 <400> 272 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 273 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC CDR3 <400> 273 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 274 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC CDR1 <400> 274 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 275 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC CDR2 <400> 275 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 276 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC CDR3 <400> 276 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 277 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC CDR1 <400> 277 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 278 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC CDR2 <400> 278 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 279 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC CDR3 <400> 279 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 280 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC CDR1 <400> 280 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 281 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC CDR2 <400> 281 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 282 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC CDR3 <400> 282 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 283 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC CDR1 <400> 283 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 284 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC CDR2 <400> 284 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 285 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC CDR3 <400> 285 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 286 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC CDR1 <400> 286 His Tyr Phe Trp Ser 1 5 <210> 287 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC CDR2 <400> 287 Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 288 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC CDR3 <400> 288 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 289 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 49 LC CDR1 <400> 289 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 290 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 49 LC CDR2 <400> 290 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 291 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 49 LC CDR3 <400> 291 Ser Ser Tyr Thr Ser Ser Ser Thr Val Val 1 5 10 <210> 292 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 49 HC CDR1 <400> 292 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 293 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 49 HC CDR2 <400> 293 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 294 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 49 HC CDR3 <400> 294 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 295 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC CDR1 <400> 295 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 296 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC CDR2 <400> 296 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 297 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC CDR3 <400> 297 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 298 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC CDR1 <400> 298 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 299 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC CDR2 <400> 299 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 300 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC CDR3 <400> 300 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 301 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC CDR1 <400> 301 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 302 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC CDR2 <400> 302 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 303 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC CDR3 <400> 303 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 304 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC CDR1 <400> 304 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 305 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC CDR2 <400> 305 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 306 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC CDR3 <400> 306 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 307 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 52 LC CDR1 <400> 307 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 308 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.52 LC CDR2 <400> 308 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 309 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.52 LC CDR3 <400> 309 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 310 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 52 HC CDR1 <400> 310 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 311 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.52 HC CDR2 <400> 311 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 312 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.52 HC CDR3 <400> 312 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 313 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC CDR1 <400> 313 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 314 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC CDR2 <400> 314 Gly Gly Ser Ser Arg Ala Thr 1 5 <210> 315 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC CDR3 <400> 315 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 316 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC CDR1 <400> 316 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 317 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC CDR2 <400> 317 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 318 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC CDR3 <400> 318 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 319 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC CDR1 <400> 319 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 320 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC CDR2 <400> 320 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 321 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC CDR3 <400> 321 Ser Ser Tyr Thr Ser Ser Ser Thr His Val 1 5 10 <210> 322 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC CDR1 <400> 322 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 323 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC CDR2 <400> 323 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 324 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC CDR3 <400> 324 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 325 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC CDR1 <400> 325 Arg Ala Ser Gln Ser Val Ser Thr Tyr Leu Ala 1 5 10 <210> 326 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC CDR2 <400> 326 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 327 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC CDR3 <400> 327 Gln Gln Tyr Gly Ser Ser Pro Ser Ile Thr 1 5 10 <210> 328 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC CDR1 <400> 328 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 329 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC CDR2 <400> 329 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 330 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC CDR3 <400> 330 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 331 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC CDR1 <400> 331 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 332 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC CDR2 <400> 332 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 333 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC CDR3 <400> 333 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 334 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC CDR1 <400> 334 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 335 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC CDR2 <400> 335 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 336 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC CDR3 <400> 336 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 337 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.57 LC CDR1 <400> 337 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 338 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.57 LC CDR2 <400> 338 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 339 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 57 LC CDR3 <400> 339 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 340 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.57 HC CDR1 <400> 340 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 341 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.57 HC CDR2 <400> 341 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 342 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 57 HC CDR3 <400> 342 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 343 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.58 LC CDR1 <400> 343 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 344 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 58 LC CDR2 <400> 344 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 345 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.58 LC CDR3 <400> 345 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 346 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 58 HC CDR1 <400> 346 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 347 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 58 HC CDR2 <400> 347 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 348 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 58 HC CDR3 <400> 348 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 349 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC CDR1 <400> 349 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 350 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC CDR2 <400> 350 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 351 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC CDR3 <400> 351 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 352 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC CDR1 <400> 352 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 353 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC CDR2 <400> 353 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 354 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC CDR3 <400> 354 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 355 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC CDR1 <400> 355 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 356 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC CDR2 <400> 356 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 357 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC CDR3 <400> 357 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 358 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 60 HC CDR1 <400> 358 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 359 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.60 HC CDR2 <400> 359 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 360 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.60 HC CDR3 <400> 360 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 361 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC CDR1 <400> 361 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 362 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC CDR2 <400> 362 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 363 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC CDR3 <400> 363 Gln Gln Tyr Tyr Ser Thr Pro Ser Ile Thr 1 5 10 <210> 364 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC CDR1 <400> 364 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 365 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC CDR2 <400> 365 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 366 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC CDR3 <400> 366 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 367 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC CDR1 <400> 367 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 368 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC CDR2 <400> 368 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 369 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC CDR3 <400> 369 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 370 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC CDR1 <400> 370 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 371 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC CDR2 <400> 371 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 372 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC CDR3 <400> 372 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 373 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC CDR1 <400> 373 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 374 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC CDR2 <400> 374 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 375 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC CDR3 <400> 375 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 376 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC CDR1 <400> 376 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 377 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC CDR2 <400> 377 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 378 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC CDR3 <400> 378 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 379 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC CDR1 <400> 379 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 380 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC CDR2 <400> 380 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 381 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC CDR3 <400> 381 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 382 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC CDR1 <400> 382 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 383 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC CDR2 <400> 383 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 384 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC CDR3 <400> 384 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 385 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC CDR1 <400> 385 Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala 1 5 10 <210> 386 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC CDR2 <400> 386 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 387 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC CDR3 <400> 387 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 388 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC CDR1 <400> 388 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 389 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC CDR2 <400> 389 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 390 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC CDR3 <400> 390 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 391 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC CDR1 <400> 391 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 392 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC CDR2 <400> 392 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 393 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC CDR3 <400> 393 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 394 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC CDR1 <400> 394 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 395 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC CDR2 <400> 395 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 396 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC CDR3 <400> 396 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 397 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC CDR1 <400> 397 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 398 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC CDR2 <400> 398 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 399 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC CDR3 <400> 399 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 400 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC CDR1 <400> 400 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 401 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC CDR2 <400> 401 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 402 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC CDR3 <400> 402 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 403 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC CDR1 <400> 403 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 404 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC CDR2 <400> 404 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 405 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC CDR3 <400> 405 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 406 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC CDR1 <400> 406 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 407 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC CDR2 <400> 407 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 408 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC CDR3 <400> 408 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 409 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC CDR1 <400> 409 Arg Ala Ser Gln Ser Val Arg Ser Ser Tyr Leu Ala 1 5 10 <210> 410 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC CDR2 <400> 410 Ala Ala Ser Thr Arg Ala Thr 1 5 <210> 411 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC CDR3 <400> 411 Gln Gln Tyr Gly Asp Ser Leu Ser Ile Thr 1 5 10 <210> 412 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC CDR1 <400> 412 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 413 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC CDR2 <400> 413 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 414 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC CDR3 <400> 414 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 415 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.70 LC CDR1 <400> 415 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 416 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.70 LC CDR2 <400> 416 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 417 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 70 LC CDR3 <400> 417 Gln Gln Tyr Gly Ser Ser Pro Ser Ile Thr 1 5 10 <210> 418 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 70 HC CDR1 <400> 418 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 419 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 70 HC CDR2 <400> 419 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 420 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 70 HC CDR3 <400> 420 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 421 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC CDR1 <400> 421 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 422 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC CDR2 <400> 422 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 423 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC CDR3 <400> 423 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 424 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC CDR1 <400> 424 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 425 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC CDR2 <400> 425 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 426 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC CDR3 <400> 426 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 427 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC CDR1 <400> 427 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Ser 1 5 10 <210> 428 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC CDR2 <400> 428 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 429 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC CDR3 <400> 429 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Pro 1 5 10 <210> 430 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC CDR1 <400> 430 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 431 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC CDR2 <400> 431 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 432 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC CDR3 <400> 432 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 433 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC CDR1 <400> 433 Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala 1 5 10 <210> 434 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC CDR2 <400> 434 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 435 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC CDR3 <400> 435 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 436 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC CDR1 <400> 436 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 437 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC CDR2 <400> 437 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 438 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC CDR3 <400> 438 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 439 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC CDR1 <400> 439 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 440 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC CDR2 <400> 440 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 441 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC CDR3 <400> 441 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 442 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC CDR1 <400> 442 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 443 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC CDR2 <400> 443 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 444 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC CDR3 <400> 444 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 445 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC CDR1 <400> 445 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 446 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC CDR2 <400> 446 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 447 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC CDR3 <400> 447 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 448 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC CDR1 <400> 448 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 449 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC CDR2 <400> 449 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 450 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC CDR3 <400> 450 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 451 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC CDR1 <400> 451 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 452 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC CDR2 <400> 452 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 453 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC CDR3 <400> 453 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 454 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC CDR1 <400> 454 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 455 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC CDR2 <400> 455 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 456 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC CDR3 <400> 456 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 457 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC CDR1 <400> 457 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 458 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC CDR2 <400> 458 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 459 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC CDR3 <400> 459 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 460 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC CDR1 <400> 460 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 461 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC CDR2 <400> 461 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 462 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC CDR3 <400> 462 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 463 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC CDR1 <400> 463 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 464 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC CDR2 <400> 464 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 465 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC CDR3 <400> 465 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 466 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC CDR1 <400> 466 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 467 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC CDR2 <400> 467 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 468 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC CDR3 <400> 468 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 469 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC CDR1 <400> 469 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 470 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC CDR2 <400> 470 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 471 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC CDR3 <400> 471 Gln Gln Tyr Tyr Ser Thr Pro Ser Ile Thr 1 5 10 <210> 472 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC CDR1 <400> 472 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 473 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC CDR2 <400> 473 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 474 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC CDR3 <400> 474 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 475 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC CDR1 <400> 475 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 476 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC CDR2 <400> 476 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 477 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC CDR3 <400> 477 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 478 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC CDR1 <400> 478 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 479 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC CDR2 <400> 479 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 480 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC CDR3 <400> 480 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 481 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC CDR1 <400> 481 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 482 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC CDR2 <400> 482 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 483 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC CDR3 <400> 483 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 484 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC CDR1 <400> 484 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 485 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC CDR2 <400> 485 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 486 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC CDR3 <400> 486 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 487 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC CDR1 <400> 487 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 488 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC CDR2 <400> 488 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 489 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC CDR3 <400> 489 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 490 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC CDR1 <400> 490 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 491 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC CDR2 <400> 491 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 492 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC CDR3 <400> 492 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 493 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC CDR1 <400> 493 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 494 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC CDR2 <400> 494 Gly Ala Ser Thr Arg Ala Thr 1 5 <210> 495 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC CDR3 <400> 495 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 496 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC CDR1 <400> 496 Gly Ser Ser Tyr Tyr Trp Gly 1 5 <210> 497 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC CDR2 <400> 497 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 498 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC CDR3 <400> 498 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 499 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC CDR1 <400> 499 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 500 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC CDR2 <400> 500 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 501 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC CDR3 <400> 501 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 502 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC CDR1 <400> 502 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 503 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC CDR2 <400> 503 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 504 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC CDR3 <400> 504 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 505 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC CDR1 <400> 505 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 506 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC CDR2 <400> 506 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 507 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC CDR3 <400> 507 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 508 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC CDR1 <400> 508 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 509 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC CDR2 <400> 509 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 510 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC CDR3 <400> 510 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 511 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC CDR1 <400> 511 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 512 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC CDR2 <400> 512 Asp Ala Ser Ser Arg Ala Thr 1 5 <210> 513 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC CDR3 <400> 513 Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 1 5 <210> 514 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC CDR1 <400> 514 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 515 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC CDR2 <400> 515 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 516 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC CDR3 <400> 516 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 517 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC CDR1 <400> 517 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 518 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC CDR2 <400> 518 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 519 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC CDR3 <400> 519 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 520 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC CDR1 <400> 520 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 521 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC CDR2 <400> 521 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 522 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC CDR3 <400> 522 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 523 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC CDR1 <400> 523 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 524 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC CDR2 <400> 524 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 525 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC CDR3 <400> 525 Gln Gln Tyr Gly Ser Ser Pro Ser Ile Thr 1 5 10 <210> 526 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC CDR1 <400> 526 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 527 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC CDR2 <400> 527 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 528 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC CDR3 <400> 528 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 529 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC CDR1 <400> 529 Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn Tyr Val Ser 1 5 10 <210> 530 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC CDR2 <400> 530 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 531 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC CDR3 <400> 531 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 532 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC CDR1 <400> 532 Thr Ser Gly Met Gly Val Gly 1 5 <210> 533 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC CDR2 <400> 533 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 534 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC CDR3 <400> 534 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 535 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC CDR1 <400> 535 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 536 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC CDR2 <400> 536 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 537 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC CDR3 <400> 537 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 538 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC CDR1 <400> 538 Thr Ser Gly Met Gly Val Gly 1 5 <210> 539 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC CDR2 <400> 539 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 540 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC CDR3 <400> 540 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 541 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC CDR1 <400> 541 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 542 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC CDR2 <400> 542 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 543 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC CDR3 <400> 543 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 544 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC CDR1 <400> 544 Thr Ser Gly Val Gly Val Gly 1 5 <210> 545 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC CDR2 <400> 545 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 546 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC CDR3 <400> 546 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 547 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC CDR1 <400> 547 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 548 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC CDR2 <400> 548 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 549 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC CDR3 <400> 549 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 550 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC CDR1 <400> 550 Thr Ser Gly Met Gly Val Gly 1 5 <210> 551 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC CDR2 <400> 551 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 552 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC CDR3 <400> 552 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 553 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC CDR1 <400> 553 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 554 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC CDR2 <400> 554 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 555 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC CDR3 <400> 555 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Arg 1 5 10 <210> 556 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC CDR1 <400> 556 Thr Ser Gly Val Gly Val Gly 1 5 <210> 557 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC CDR2 <400> 557 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 558 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC CDR3 <400> 558 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 559 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC CDR1 <400> 559 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 560 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC CDR2 <400> 560 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 561 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC CDR3 <400> 561 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 562 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC CDR1 <400> 562 Thr Ser Gly Met Gly Val Gly 1 5 <210> 563 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC CDR2 <400> 563 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 564 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC CDR3 <400> 564 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 565 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC CDR1 <400> 565 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 566 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC CDR2 <400> 566 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 567 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC CDR3 <400> 567 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 568 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC CDR1 <400> 568 Thr Ser Gly Val Gly Val Gly 1 5 <210> 569 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC CDR2 <400> 569 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 570 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC CDR3 <400> 570 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 571 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 96 LC CDR1 <400> 571 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 572 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 96 LC CDR2 <400> 572 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 573 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 96 LC CDR3 <400> 573 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 574 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 96 HC CDR1 <400> 574 Thr Ser Gly Met Gly Val Gly 1 5 <210> 575 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 96 HC CDR2 <400> 575 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 576 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 96 HC CDR3 <400> 576 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 577 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC CDR1 <400> 577 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 578 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC CDR2 <400> 578 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 579 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC CDR3 <400> 579 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 580 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC CDR1 <400> 580 Thr Ser Gly Met Gly Val Ser 1 5 <210> 581 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC CDR2 <400> 581 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 582 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC CDR3 <400> 582 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 583 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 98 LC CDR1 <400> 583 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 584 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.98 LC CDR2 <400> 584 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 585 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 98 LC CDR3 <400> 585 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 586 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 98 HC CDR1 <400> 586 Thr Ser Gly Met Gly Val Gly 1 5 <210> 587 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 98 HC CDR2 <400> 587 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 588 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 98 HC CDR3 <400> 588 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 589 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC CDR1 <400> 589 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 590 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC CDR2 <400> 590 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 591 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC CDR3 <400> 591 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 592 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC CDR1 <400> 592 Thr Ser Gly Met Gly Val Gly 1 5 <210> 593 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC CDR2 <400> 593 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 594 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC CDR3 <400> 594 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 595 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC CDR1 <400> 595 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 596 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC CDR2 <400> 596 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 597 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC CDR3 <400> 597 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 598 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 100 HC CDR1 <400> 598 Thr Ser Gly Met Gly Val Gly 1 5 <210> 599 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 100 HC CDR2 <400> 599 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 600 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.100 HC CDR3 <400> 600 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 601 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 101 LC CDR1 <400> 601 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 602 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 101 LC CDR2 <400> 602 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 603 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 101 LC CDR3 <400> 603 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 604 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 101 HC CDR1 <400> 604 Thr Ser Gly Met Gly Val Gly 1 5 <210> 605 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 101 HC CDR2 <400> 605 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 606 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 101 HC CDR3 <400> 606 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 607 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC CDR1 <400> 607 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 608 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC CDR2 <400> 608 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 609 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC CDR3 <400> 609 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 610 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC CDR1 <400> 610 Thr Ser Gly Met Gly Val Gly 1 5 <210> 611 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC CDR2 <400> 611 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 612 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC CDR3 <400> 612 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 613 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC CDR1 <400> 613 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 614 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC CDR2 <400> 614 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 615 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC CDR3 <400> 615 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 616 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC CDR1 <400> 616 Thr Ser Gly Val Gly Val Gly 1 5 <210> 617 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC CDR2 <400> 617 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 618 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC CDR3 <400> 618 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 619 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC CDR1 <400> 619 Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 620 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC CDR2 <400> 620 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 621 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC CDR3 <400> 621 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 622 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC CDR1 <400> 622 Thr Ser Gly Val Gly Val Gly 1 5 <210> 623 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC CDR2 <400> 623 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 624 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC CDR3 <400> 624 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 625 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC CDR1 <400> 625 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 626 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC CDR2 <400> 626 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 627 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC CDR3 <400> 627 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 628 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC CDR1 <400> 628 Thr Ser Gly Val Gly Val Gly 1 5 <210> 629 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC CDR2 <400> 629 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 630 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC CDR3 <400> 630 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 631 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC CDR1 <400> 631 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 632 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC CDR2 <400> 632 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 633 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC CDR3 <400> 633 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 634 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC CDR1 <400> 634 Thr Ser Gly Met Gly Val Gly 1 5 <210> 635 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC CDR2 <400> 635 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 636 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC CDR3 <400> 636 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 637 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC CDR1 <400> 637 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 638 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC CDR2 <400> 638 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 639 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC CDR3 <400> 639 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 640 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC CDR1 <400> 640 Thr Ser Gly Met Gly Val Gly 1 5 <210> 641 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC CDR2 <400> 641 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 642 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC CDR3 <400> 642 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 643 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC CDR1 <400> 643 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 644 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC CDR2 <400> 644 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 645 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC CDR3 <400> 645 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 646 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC CDR1 <400> 646 Thr Ser Gly Met Gly Val Gly 1 5 <210> 647 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC CDR2 <400> 647 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 648 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC CDR3 <400> 648 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 649 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC CDR1 <400> 649 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 650 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC CDR2 <400> 650 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 651 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC CDR3 <400> 651 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 652 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC CDR1 <400> 652 Thr Ser Gly Met Gly Val Gly 1 5 <210> 653 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC CDR2 <400> 653 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 654 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC CDR3 <400> 654 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 655 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC CDR1 <400> 655 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 656 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC CDR2 <400> 656 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 657 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC CDR3 <400> 657 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 658 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 110 HC CDR1 <400> 658 Thr Ser Gly Met Gly Val Gly 1 5 <210> 659 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.110 HC CDR2 <400> 659 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 660 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.110 HC CDR3 <400> 660 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 661 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC CDR1 <400> 661 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 662 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC CDR2 <400> 662 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 663 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC CDR3 <400> 663 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 664 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC CDR1 <400> 664 Thr Ser Gly Met Gly Val Gly 1 5 <210> 665 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC CDR2 <400> 665 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 666 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC CDR3 <400> 666 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 667 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC CDR1 <400> 667 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 668 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC CDR2 <400> 668 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 669 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC CDR3 <400> 669 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 670 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC CDR1 <400> 670 Thr Ser Gly Val Gly Val Gly 1 5 <210> 671 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC CDR2 <400> 671 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 672 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC CDR3 <400> 672 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 673 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC CDR1 <400> 673 Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn Tyr Ile Ser 1 5 10 <210> 674 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC CDR2 <400> 674 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 675 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC CDR3 <400> 675 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 676 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC CDR1 <400> 676 Thr Ser Gly Val Gly Val Gly 1 5 <210> 677 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC CDR2 <400> 677 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 678 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC CDR3 <400> 678 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 679 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC CDR1 <400> 679 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 680 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC CDR2 <400> 680 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 681 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC CDR3 <400> 681 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 682 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC CDR1 <400> 682 Thr Ser Gly Met Gly Val Gly 1 5 <210> 683 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC CDR2 <400> 683 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 684 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC CDR3 <400> 684 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 685 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC CDR1 <400> 685 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 686 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC CDR2 <400> 686 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 687 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC CDR3 <400> 687 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 688 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC CDR1 <400> 688 Thr Ser Gly Met Gly Val Gly 1 5 <210> 689 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC CDR2 <400> 689 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 690 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC CDR3 <400> 690 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 691 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC CDR1 <400> 691 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 692 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC CDR2 <400> 692 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 693 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC CDR3 <400> 693 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 694 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC CDR1 <400> 694 Thr Ser Gly Met Gly Val Gly 1 5 <210> 695 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC CDR2 <400> 695 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 696 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC CDR3 <400> 696 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 697 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC CDR1 <400> 697 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 698 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC CDR2 <400> 698 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 699 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC CDR3 <400> 699 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 700 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC CDR1 <400> 700 Thr Ser Gly Met Gly Val Gly 1 5 <210> 701 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC CDR2 <400> 701 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 702 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC CDR3 <400> 702 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 703 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC CDR1 <400> 703 Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 704 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC CDR2 <400> 704 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 705 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC CDR3 <400> 705 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 706 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC CDR1 <400> 706 Thr Ser Gly Met Gly Val Gly 1 5 <210> 707 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC CDR2 <400> 707 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 708 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC CDR3 <400> 708 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 709 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC CDR1 <400> 709 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 710 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC CDR2 <400> 710 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 711 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC CDR3 <400> 711 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 712 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC CDR1 <400> 712 Thr Ser Gly Met Gly Val Gly 1 5 <210> 713 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC CDR2 <400> 713 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 714 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC CDR3 <400> 714 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 715 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 120 LC CDR1 <400> 715 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 716 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.120 LC CDR2 <400> 716 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 717 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.120 LC CDR3 <400> 717 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 718 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 120 HC CDR1 <400> 718 Thr Ser Gly Val Gly Val Gly 1 5 <210> 719 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 120 HC CDR2 <400> 719 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 720 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 120 HC CDR3 <400> 720 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 721 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC CDR1 <400> 721 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 722 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC CDR2 <400> 722 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 723 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC CDR3 <400> 723 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 724 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC CDR1 <400> 724 Thr Ser Gly Met Gly Val Gly 1 5 <210> 725 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC CDR2 <400> 725 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 726 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC CDR3 <400> 726 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 727 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC CDR1 <400> 727 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 728 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC CDR2 <400> 728 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 729 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC CDR3 <400> 729 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 730 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC CDR1 <400> 730 Thr Ser Gly Met Gly Val Gly 1 5 <210> 731 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC CDR2 <400> 731 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 732 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC CDR3 <400> 732 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 733 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC CDR1 <400> 733 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 734 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC CDR2 <400> 734 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 735 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC CDR3 <400> 735 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 736 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC CDR1 <400> 736 Thr Ser Gly Met Gly Val Gly 1 5 <210> 737 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC CDR2 <400> 737 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 738 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC CDR3 <400> 738 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 739 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC CDR1 <400> 739 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 740 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC CDR2 <400> 740 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 741 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC CDR3 <400> 741 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 742 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC CDR1 <400> 742 Thr Ser Gly Val Gly Val Gly 1 5 <210> 743 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC CDR2 <400> 743 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 744 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC CDR3 <400> 744 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 745 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC CDR1 <400> 745 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 746 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC CDR2 <400> 746 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 747 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC CDR3 <400> 747 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 748 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC CDR1 <400> 748 Thr Ser Gly Met Gly Val Gly 1 5 <210> 749 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC CDR2 <400> 749 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 750 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC CDR3 <400> 750 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 751 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC CDR1 <400> 751 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 752 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC CDR2 <400> 752 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 753 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC CDR3 <400> 753 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 754 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC CDR1 <400> 754 Thr Ser Gly Met Gly Val Gly 1 5 <210> 755 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC CDR2 <400> 755 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 756 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC CDR3 <400> 756 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 757 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC CDR1 <400> 757 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 758 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC CDR2 <400> 758 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 759 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC CDR3 <400> 759 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 760 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC CDR1 <400> 760 Thr Ser Gly Val Gly Val Gly 1 5 <210> 761 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC CDR2 <400> 761 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 762 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC CDR3 <400> 762 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 763 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC CDR1 <400> 763 Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Phe Val Ser 1 5 10 <210> 764 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC CDR2 <400> 764 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 765 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC CDR3 <400> 765 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 766 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.128 HC CDR1 <400> 766 Thr Ser Gly Val Gly Val Gly 1 5 <210> 767 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.128 HC CDR2 <400> 767 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 768 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 128 HC CDR3 <400> 768 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 769 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC CDR1 <400> 769 Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 770 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC CDR2 <400> 770 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 771 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC CDR3 <400> 771 Gly Thr Trp Asp Asn Asn Leu Ser Ala Gly Val 1 5 10 <210> 772 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC CDR1 <400> 772 Thr Ser Gly Val Gly Val Gly 1 5 <210> 773 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC CDR2 <400> 773 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 774 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC CDR3 <400> 774 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 775 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.130 LC CDR1 <400> 775 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 776 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.130 LC CDR2 <400> 776 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 777 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 130 LC CDR3 <400> 777 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 778 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 130 HC CDR1 <400> 778 Thr Ser Gly Met Gly Val Gly 1 5 <210> 779 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 130 HC CDR2 <400> 779 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 780 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 130 HC CDR3 <400> 780 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 781 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC CDR1 <400> 781 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 782 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC CDR2 <400> 782 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 783 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC CDR3 <400> 783 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 784 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC CDR1 <400> 784 Thr Ser Gly Val Gly Val Gly 1 5 <210> 785 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC CDR2 <400> 785 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 786 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC CDR3 <400> 786 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 787 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC CDR1 <400> 787 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 788 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC CDR2 <400> 788 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 789 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC CDR3 <400> 789 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 790 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC CDR1 <400> 790 Thr Ser Gly Met Gly Val Gly 1 5 <210> 791 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC CDR2 <400> 791 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 792 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC CDR3 <400> 792 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 793 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC CDR1 <400> 793 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 794 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC CDR2 <400> 794 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 795 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC CDR3 <400> 795 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 796 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC CDR1 <400> 796 Thr Ser Gly Met Gly Val Gly 1 5 <210> 797 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC CDR2 <400> 797 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 798 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC CDR3 <400> 798 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 799 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC CDR1 <400> 799 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 800 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC CDR2 <400> 800 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 801 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC CDR3 <400> 801 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 802 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC CDR1 <400> 802 Thr Ser Gly Met Gly Val Gly 1 5 <210> 803 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC CDR2 <400> 803 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 804 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC CDR3 <400> 804 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 805 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC CDR1 <400> 805 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 806 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC CDR2 <400> 806 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 807 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC CDR3 <400> 807 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 808 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC CDR1 <400> 808 Thr Ser Gly Met Gly Val Gly 1 5 <210> 809 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC CDR2 <400> 809 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 810 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC CDR3 <400> 810 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 811 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC CDR1 <400> 811 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 812 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC CDR2 <400> 812 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 813 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC CDR3 <400> 813 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 814 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC CDR1 <400> 814 Thr Ser Gly Met Gly Val Gly 1 5 <210> 815 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC CDR2 <400> 815 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 816 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC CDR3 <400> 816 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 817 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC CDR1 <400> 817 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 818 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC CDR2 <400> 818 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 819 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC CDR3 <400> 819 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 820 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC CDR1 <400> 820 Thr Ser Gly Val Gly Val Gly 1 5 <210> 821 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC CDR2 <400> 821 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 822 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC CDR3 <400> 822 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 823 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC CDR1 <400> 823 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 824 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC CDR2 <400> 824 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 825 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC CDR3 <400> 825 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 826 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC CDR1 <400> 826 Thr Ser Gly Val Gly Val Gly 1 5 <210> 827 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC CDR2 <400> 827 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 828 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC CDR3 <400> 828 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 829 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC CDR1 <400> 829 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 830 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC CDR2 <400> 830 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 831 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC CDR3 <400> 831 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 832 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC CDR1 <400> 832 Thr Ser Gly Val Gly Val Gly 1 5 <210> 833 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC CDR2 <400> 833 Leu Ile Asp Trp Asp Asp Asn Lys Tyr His Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 834 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC CDR3 <400> 834 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 835 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 140 LC CDR1 <400> 835 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 836 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 140 LC CDR2 <400> 836 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 837 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 140 LC CDR3 <400> 837 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 838 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 140 HC CDR1 <400> 838 Thr Ser Gly Met Gly Val Ser 1 5 <210> 839 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 140 HC CDR2 <400> 839 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 840 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 140 HC CDR3 <400> 840 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 841 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC CDR1 <400> 841 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 842 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC CDR2 <400> 842 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 843 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC CDR3 <400> 843 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 844 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC CDR1 <400> 844 Thr Ser Gly Met Gly Val Gly 1 5 <210> 845 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC CDR2 <400> 845 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 846 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC CDR3 <400> 846 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 847 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC CDR1 <400> 847 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 848 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC CDR2 <400> 848 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 849 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC CDR3 <400> 849 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 850 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC CDR1 <400> 850 Thr Ser Gly Met Gly Val Gly 1 5 <210> 851 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC CDR2 <400> 851 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 852 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC CDR3 <400> 852 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 853 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC CDR1 <400> 853 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 854 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC CDR2 <400> 854 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 855 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC CDR3 <400> 855 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 856 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC CDR1 <400> 856 Thr Ser Gly Val Gly Val Gly 1 5 <210> 857 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC CDR2 <400> 857 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 858 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC CDR3 <400> 858 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 859 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC CDR1 <400> 859 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 860 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC CDR2 <400> 860 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 861 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC CDR3 <400> 861 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 862 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC CDR1 <400> 862 Thr Ser Gly Met Gly Val Gly 1 5 <210> 863 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC CDR2 <400> 863 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 864 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC CDR3 <400> 864 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 865 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC CDR1 <400> 865 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 866 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC CDR2 <400> 866 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 867 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC CDR3 <400> 867 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 868 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC CDR1 <400> 868 Thr Ser Gly Val Gly Val Gly 1 5 <210> 869 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC CDR2 <400> 869 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 870 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC CDR3 <400> 870 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 871 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC CDR1 <400> 871 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 872 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC CDR2 <400> 872 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 873 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC CDR3 <400> 873 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 874 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC CDR1 <400> 874 Thr Ser Gly Met Gly Val Gly 1 5 <210> 875 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC CDR2 <400> 875 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 876 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC CDR3 <400> 876 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 877 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC CDR1 <400> 877 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 878 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC CDR2 <400> 878 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 879 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC CDR3 <400> 879 Gly Thr Trp Asp Ser Ser Leu Ser Gly Gly Val 1 5 10 <210> 880 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC CDR1 <400> 880 Thr Ser Gly Met Gly Val Gly 1 5 <210> 881 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC CDR2 <400> 881 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 882 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC CDR3 <400> 882 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 883 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC CDR1 <400> 883 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 884 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC CDR2 <400> 884 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 885 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC CDR3 <400> 885 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 886 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC CDR1 <400> 886 Thr Ser Gly Met Gly Val Gly 1 5 <210> 887 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC CDR2 <400> 887 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 888 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC CDR3 <400> 888 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 889 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC CDR1 <400> 889 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 890 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC CDR2 <400> 890 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 891 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC CDR3 <400> 891 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 892 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC CDR1 <400> 892 Thr Ser Gly Met Gly Val Gly 1 5 <210> 893 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC CDR2 <400> 893 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 894 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC CDR3 <400> 894 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 895 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC CDR1 <400> 895 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 896 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC CDR2 <400> 896 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 897 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC CDR3 <400> 897 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 898 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC CDR1 <400> 898 Thr Ser Gly Met Gly Val Gly 1 5 <210> 899 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC CDR2 <400> 899 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 900 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC CDR3 <400> 900 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 901 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC CDR1 <400> 901 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 902 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC CDR2 <400> 902 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 903 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC CDR3 <400> 903 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 904 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC CDR1 <400> 904 Thr Ser Gly Val Gly Val Gly 1 5 <210> 905 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC CDR2 <400> 905 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 906 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC CDR3 <400> 906 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 907 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC CDR1 <400> 907 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 908 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC CDR2 <400> 908 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 909 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC CDR3 <400> 909 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 910 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC CDR1 <400> 910 Thr Ser Gly Met Gly Val Gly 1 5 <210> 911 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC CDR2 <400> 911 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 912 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC CDR3 <400> 912 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 913 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC CDR1 <400> 913 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 914 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC CDR2 <400> 914 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 915 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC CDR3 <400> 915 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 916 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC CDR1 <400> 916 Thr Ser Gly Val Gly Val Gly 1 5 <210> 917 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC CDR2 <400> 917 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 918 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC CDR3 <400> 918 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 919 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC CDR1 <400> 919 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 920 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC CDR2 <400> 920 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 921 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC CDR3 <400> 921 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 922 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC CDR1 <400> 922 Thr Ser Gly Val Gly Val Gly 1 5 <210> 923 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC CDR2 <400> 923 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 924 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC CDR3 <400> 924 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 925 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC CDR1 <400> 925 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 926 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC CDR2 <400> 926 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 927 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC CDR3 <400> 927 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 928 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC CDR1 <400> 928 Thr Ser Gly Met Gly Val Gly 1 5 <210> 929 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC CDR2 <400> 929 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 930 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC CDR3 <400> 930 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 931 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC CDR1 <400> 931 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 932 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC CDR2 <400> 932 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 933 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC CDR3 <400> 933 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 934 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC CDR1 <400> 934 Thr Ser Gly Met Gly Val Gly 1 5 <210> 935 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC CDR2 <400> 935 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 936 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC CDR3 <400> 936 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 937 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC CDR1 <400> 937 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 938 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC CDR2 <400> 938 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 939 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC CDR3 <400> 939 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 940 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC CDR1 <400> 940 Thr Ser Gly Val Gly Val Gly 1 5 <210> 941 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC CDR2 <400> 941 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 942 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC CDR3 <400> 942 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 943 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC CDR1 <400> 943 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 944 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC CDR2 <400> 944 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 945 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC CDR3 <400> 945 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 946 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC CDR1 <400> 946 Thr Ser Gly Val Gly Val Gly 1 5 <210> 947 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC CDR2 <400> 947 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 948 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC CDR3 <400> 948 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 949 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC CDR1 <400> 949 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 950 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC CDR2 <400> 950 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 951 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC CDR3 <400> 951 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 952 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC CDR1 <400> 952 Thr Ser Gly Val Gly Val Gly 1 5 <210> 953 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC CDR2 <400> 953 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 954 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC CDR3 <400> 954 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 955 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 160 LC CDR1 <400> 955 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 956 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 160 LC CDR2 <400> 956 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 957 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 160 LC CDR3 <400> 957 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 958 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 160 HC CDR1 <400> 958 Thr Ser Gly Val Gly Val Gly 1 5 <210> 959 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 160 HC CDR2 <400> 959 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 960 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 160 HC CDR3 <400> 960 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 961 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC CDR1 <400> 961 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 962 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC CDR2 <400> 962 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 963 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC CDR3 <400> 963 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 964 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC CDR1 <400> 964 Thr Ser Gly Met Gly Val Gly 1 5 <210> 965 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC CDR2 <400> 965 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 966 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC CDR3 <400> 966 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 967 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC CDR1 <400> 967 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 968 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC CDR2 <400> 968 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 969 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC CDR3 <400> 969 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 970 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC CDR1 <400> 970 Thr Ser Gly Val Gly Val Gly 1 5 <210> 971 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC CDR2 <400> 971 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 972 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC CDR3 <400> 972 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 973 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC CDR1 <400> 973 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 974 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC CDR2 <400> 974 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 975 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC CDR3 <400> 975 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 976 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC CDR1 <400> 976 Thr Ser Gly Met Gly Val Gly 1 5 <210> 977 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC CDR2 <400> 977 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 978 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC CDR3 <400> 978 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 979 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC CDR1 <400> 979 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 980 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC CDR2 <400> 980 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 981 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC CDR3 <400> 981 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 982 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC CDR1 <400> 982 Thr Ser Gly Val Gly Val Gly 1 5 <210> 983 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC CDR2 <400> 983 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 984 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC CDR3 <400> 984 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 985 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC CDR1 <400> 985 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 986 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC CDR2 <400> 986 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 987 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC CDR3 <400> 987 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 988 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC CDR1 <400> 988 Thr Ser Gly Met Gly Val Gly 1 5 <210> 989 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC CDR2 <400> 989 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 990 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC CDR3 <400> 990 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 991 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC CDR1 <400> 991 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 992 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC CDR2 <400> 992 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 993 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC CDR3 <400> 993 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 994 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC CDR1 <400> 994 Thr Ser Gly Met Gly Val Gly 1 5 <210> 995 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC CDR2 <400> 995 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 996 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC CDR3 <400> 996 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 997 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC CDR1 <400> 997 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 998 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC CDR2 <400> 998 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 999 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC CDR3 <400> 999 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1000 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC CDR1 <400> 1000 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1001 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC CDR2 <400> 1001 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1002 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC CDR3 <400> 1002 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1003 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC CDR1 <400> 1003 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1004 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC CDR2 <400> 1004 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1005 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC CDR3 <400> 1005 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1006 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC CDR1 <400> 1006 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1007 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC CDR2 <400> 1007 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1008 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC CDR3 <400> 1008 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1009 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC CDR1 <400> 1009 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 1010 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC CDR2 <400> 1010 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1011 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC CDR3 <400> 1011 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1012 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC CDR1 <400> 1012 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1013 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC CDR2 <400> 1013 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1014 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC CDR3 <400> 1014 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1015 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC CDR1 <400> 1015 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1016 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC CDR2 <400> 1016 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1017 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC CDR3 <400> 1017 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1018 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC CDR1 <400> 1018 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1019 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC CDR2 <400> 1019 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1020 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC CDR3 <400> 1020 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1021 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC CDR1 <400> 1021 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1022 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC CDR2 <400> 1022 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1023 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC CDR3 <400> 1023 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1024 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC CDR1 <400> 1024 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1025 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC CDR2 <400> 1025 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1026 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC CDR3 <400> 1026 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1027 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.172 LC CDR1 <400> 1027 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1028 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 172 LC CDR2 <400> 1028 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1029 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.172 LC CDR3 <400> 1029 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1030 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC CDR1 <400> 1030 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1031 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC CDR2 <400> 1031 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1032 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC CDR3 <400> 1032 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1033 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC CDR1 <400> 1033 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1034 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC CDR2 <400> 1034 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1035 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC CDR3 <400> 1035 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1036 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC CDR1 <400> 1036 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1037 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC CDR2 <400> 1037 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1038 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC CDR3 <400> 1038 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1039 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC CDR1 <400> 1039 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1040 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC CDR2 <400> 1040 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1041 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC CDR3 <400> 1041 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1042 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC CDR1 <400> 1042 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1043 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC CDR2 <400> 1043 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1044 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC CDR3 <400> 1044 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1045 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC CDR1 <400> 1045 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1046 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC CDR2 <400> 1046 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1047 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC CDR3 <400> 1047 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1048 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC CDR1 <400> 1048 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1049 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC CDR2 <400> 1049 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1050 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC CDR3 <400> 1050 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1051 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC CDR1 <400> 1051 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1052 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC CDR2 <400> 1052 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1053 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC CDR3 <400> 1053 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1054 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC CDR1 <400> 1054 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1055 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC CDR2 <400> 1055 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1056 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC CDR3 <400> 1056 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1057 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC CDR1 <400> 1057 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1058 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC CDR2 <400> 1058 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1059 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC CDR3 <400> 1059 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1060 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC CDR1 <400> 1060 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1061 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC CDR2 <400> 1061 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1062 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC CDR3 <400> 1062 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1063 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC CDR1 <400> 1063 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1064 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC CDR2 <400> 1064 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1065 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC CDR3 <400> 1065 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1066 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC CDR1 <400> 1066 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1067 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC CDR2 <400> 1067 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1068 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC CDR3 <400> 1068 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1069 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC CDR1 <400> 1069 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1070 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC CDR2 <400> 1070 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1071 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC CDR3 <400> 1071 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1072 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC CDR1 <400> 1072 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1073 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC CDR2 <400> 1073 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1074 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC CDR3 <400> 1074 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1075 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC CDR1 <400> 1075 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1076 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC CDR2 <400> 1076 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1077 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC CDR3 <400> 1077 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1078 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC CDR1 <400> 1078 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1079 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC CDR2 <400> 1079 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1080 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC CDR3 <400> 1080 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1081 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC CDR1 <400> 1081 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1082 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC CDR2 <400> 1082 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1083 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC CDR3 <400> 1083 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1084 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC CDR1 <400> 1084 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1085 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC CDR2 <400> 1085 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1086 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC CDR3 <400> 1086 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1087 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC CDR1 <400> 1087 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1088 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC CDR2 <400> 1088 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1089 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC CDR3 <400> 1089 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1090 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC CDR1 <400> 1090 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1091 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC CDR2 <400> 1091 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1092 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC CDR3 <400> 1092 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1093 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC CDR1 <400> 1093 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1094 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC CDR2 <400> 1094 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1095 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC CDR3 <400> 1095 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1096 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC CDR1 <400> 1096 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1097 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC CDR2 <400> 1097 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1098 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC CDR3 <400> 1098 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1099 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC CDR1 <400> 1099 Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn Tyr Val Ser 1 5 10 <210> 1100 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC CDR2 <400> 1100 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 1101 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC CDR3 <400> 1101 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1102 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC CDR1 <400> 1102 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1103 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC CDR2 <400> 1103 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1104 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC CDR3 <400> 1104 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1105 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC CDR1 <400> 1105 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1106 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC CDR2 <400> 1106 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1107 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC CDR3 <400> 1107 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1108 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC CDR1 <400> 1108 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1109 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC CDR2 <400> 1109 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1110 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC CDR3 <400> 1110 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1111 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC CDR1 <400> 1111 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1112 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC CDR2 <400> 1112 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1113 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC CDR3 <400> 1113 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1114 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC CDR1 <400> 1114 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1115 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC CDR2 <400> 1115 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1116 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC CDR3 <400> 1116 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1117 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC CDR1 <400> 1117 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1118 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC CDR2 <400> 1118 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1119 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC CDR3 <400> 1119 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1120 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC CDR1 <400> 1120 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1121 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC CDR2 <400> 1121 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1122 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC CDR3 <400> 1122 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1123 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC CDR1 <400> 1123 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1124 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC CDR2 <400> 1124 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1125 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC CDR3 <400> 1125 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1126 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC CDR1 <400> 1126 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1127 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC CDR2 <400> 1127 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1128 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC CDR3 <400> 1128 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1129 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC CDR1 <400> 1129 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1130 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC CDR2 <400> 1130 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1131 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC CDR3 <400> 1131 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1132 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC CDR1 <400> 1132 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1133 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC CDR2 <400> 1133 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1134 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC CDR3 <400> 1134 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1135 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC CDR1 <400> 1135 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1136 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC CDR2 <400> 1136 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1137 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC CDR3 <400> 1137 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1138 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC CDR1 <400> 1138 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1139 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC CDR2 <400> 1139 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1140 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC CDR3 <400> 1140 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1141 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 191 LC CDR1 <400> 1141 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1142 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 191 LC CDR2 <400> 1142 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1143 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 191 LC CDR3 <400> 1143 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1144 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 191 HC CDR1 <400> 1144 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1145 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 191 HC CDR2 <400> 1145 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1146 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 191 HC CDR3 <400> 1146 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1147 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC CDR1 <400> 1147 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1148 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC CDR2 <400> 1148 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1149 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC CDR3 <400> 1149 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1150 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC CDR1 <400> 1150 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1151 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC CDR2 <400> 1151 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1152 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC CDR3 <400> 1152 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1153 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC CDR1 <400> 1153 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1154 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC CDR2 <400> 1154 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1155 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC CDR3 <400> 1155 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1156 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC CDR1 <400> 1156 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1157 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC CDR2 <400> 1157 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1158 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC CDR3 <400> 1158 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1159 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC CDR1 <400> 1159 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1160 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC CDR2 <400> 1160 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1161 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC CDR3 <400> 1161 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1162 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC CDR1 <400> 1162 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1163 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC CDR2 <400> 1163 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1164 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC CDR3 <400> 1164 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1165 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC CDR1 <400> 1165 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 1166 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC CDR2 <400> 1166 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 1167 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC CDR3 <400> 1167 Gln Ser Tyr Asp Ser Ser Asp Trp Val 1 5 <210> 1168 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC CDR1 <400> 1168 Arg Tyr Gly Ile Ser 1 5 <210> 1169 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC CDR2 <400> 1169 Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu Gln 1 5 10 15 Gly <210> 1170 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC CDR3 <400> 1170 Val Leu Gly Ile Ala Val Ala Gly Thr Pro Ile 1 5 10 <210> 1171 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC CDR1 <400> 1171 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1172 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC CDR2 <400> 1172 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1173 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC CDR3 <400> 1173 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1174 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC CDR1 <400> 1174 Ser Tyr Ala Ile Ser 1 5 <210> 1175 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC CDR2 <400> 1175 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1176 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC CDR3 <400> 1176 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1177 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC CDR1 <400> 1177 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1178 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC CDR2 <400> 1178 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1179 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC CDR3 <400> 1179 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Ile 1 5 10 <210> 1180 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC CDR1 <400> 1180 Ser Tyr Ala Ile Ser 1 5 <210> 1181 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC CDR2 <400> 1181 Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1182 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC CDR3 <400> 1182 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1183 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC CDR1 <400> 1183 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1184 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC CDR2 <400> 1184 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1185 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC CDR3 <400> 1185 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1186 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC CDR1 <400> 1186 Ser Tyr Ala Ile Ser 1 5 <210> 1187 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC CDR2 <400> 1187 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1188 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC CDR3 <400> 1188 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1189 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC CDR1 <400> 1189 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1190 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC CDR2 <400> 1190 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1191 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC CDR3 <400> 1191 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Ile 1 5 10 <210> 1192 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC CDR1 <400> 1192 Ser Tyr Ala Ile Ser 1 5 <210> 1193 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC CDR2 <400> 1193 Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1194 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC CDR3 <400> 1194 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1195 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC CDR1 <400> 1195 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1196 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC CDR2 <400> 1196 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1197 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC CDR3 <400> 1197 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1198 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC CDR1 <400> 1198 Ser Tyr Ala Ile Ser 1 5 <210> 1199 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC CDR2 <400> 1199 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1200 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC CDR3 <400> 1200 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1201 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC CDR1 <400> 1201 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1202 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC CDR2 <400> 1202 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1203 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC CDR3 <400> 1203 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1204 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC CDR1 <400> 1204 Ser Tyr Ala Ile Ser 1 5 <210> 1205 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC CDR2 <400> 1205 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1206 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC CDR3 <400> 1206 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp Tyr 1 5 10 15 <210> 1207 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC CDR1 <400> 1207 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1208 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC CDR2 <400> 1208 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1209 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC CDR3 <400> 1209 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1210 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC CDR1 <400> 1210 Ser Tyr Ala Ile Ser 1 5 <210> 1211 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC CDR2 <400> 1211 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1212 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC CDR3 <400> 1212 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp Tyr 1 5 10 15 <210> 1213 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC CDR1 <400> 1213 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1214 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC CDR2 <400> 1214 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1215 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC CDR3 <400> 1215 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1216 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC CDR1 <400> 1216 Arg Phe Ala Met His 1 5 <210> 1217 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC CDR2 <400> 1217 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1218 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC CDR3 <400> 1218 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1219 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC CDR1 <400> 1219 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Thr Val Asn 1 5 10 <210> 1220 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC CDR2 <400> 1220 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1221 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC CDR3 <400> 1221 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1222 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC CDR1 <400> 1222 Arg Phe Ala Met His 1 5 <210> 1223 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC CDR2 <400> 1223 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1224 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC CDR3 <400> 1224 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1225 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC CDR1 <400> 1225 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1226 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC CDR2 <400> 1226 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1227 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC CDR3 <400> 1227 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1228 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC CDR1 <400> 1228 Ser Phe Ala Met His 1 5 <210> 1229 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC CDR2 <400> 1229 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1230 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC CDR3 <400> 1230 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1231 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC CDR1 <400> 1231 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1232 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC CDR2 <400> 1232 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1233 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC CDR3 <400> 1233 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1234 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC CDR1 <400> 1234 Asn Phe Ala Met His 1 5 <210> 1235 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC CDR2 <400> 1235 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1236 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC CDR3 <400> 1236 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1237 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC CDR1 <400> 1237 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1238 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC CDR2 <400> 1238 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1239 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC CDR3 <400> 1239 Ala Thr Trp Asp Asp Ala Leu Ser Gly Trp Val 1 5 10 <210> 1240 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC CDR1 <400> 1240 Arg Phe Ala Met His 1 5 <210> 1241 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC CDR2 <400> 1241 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1242 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC CDR3 <400> 1242 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1243 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC CDR1 <400> 1243 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1244 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC CDR2 <400> 1244 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1245 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC CDR3 <400> 1245 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1246 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC CDR1 <400> 1246 Arg Phe Ala Met His 1 5 <210> 1247 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC CDR2 <400> 1247 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1248 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC CDR3 <400> 1248 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1249 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC CDR1 <400> 1249 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Ala Val Asn 1 5 10 <210> 1250 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC CDR2 <400> 1250 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1251 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC CDR3 <400> 1251 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1252 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC CDR1 <400> 1252 Ser Phe Ala Met His 1 5 <210> 1253 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC CDR2 <400> 1253 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1254 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC CDR3 <400> 1254 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1255 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC CDR1 <400> 1255 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1256 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC CDR2 <400> 1256 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1257 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC CDR3 <400> 1257 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1258 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC CDR1 <400> 1258 Arg Phe Ala Met His 1 5 <210> 1259 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC CDR2 <400> 1259 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1260 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC CDR3 <400> 1260 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1261 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC CDR1 <400> 1261 Ser Gly Ser Arg Ser Asn Ile Gly Gly Asn Thr Val Asn 1 5 10 <210> 1262 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC CDR2 <400> 1262 Gly Asp Asn Gln Arg Pro Ser 1 5 <210> 1263 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC CDR3 <400> 1263 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1264 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC CDR1 <400> 1264 Thr Tyr Ser Met His 1 5 <210> 1265 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC CDR2 <400> 1265 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1266 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC CDR3 <400> 1266 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1267 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC CDR1 <400> 1267 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1268 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC CDR2 <400> 1268 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1269 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC CDR3 <400> 1269 Ala Ala Trp Glu Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1270 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC CDR1 <400> 1270 Asn Phe Ala Met His 1 5 <210> 1271 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC CDR2 <400> 1271 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1272 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC CDR3 <400> 1272 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1273 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC CDR1 <400> 1273 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1274 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC CDR2 <400> 1274 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1275 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC CDR3 <400> 1275 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1276 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC CDR1 <400> 1276 Arg Phe Ala Met His 1 5 <210> 1277 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC CDR2 <400> 1277 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1278 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC CDR3 <400> 1278 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1279 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC CDR1 <400> 1279 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1280 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC CDR2 <400> 1280 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1281 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC CDR3 <400> 1281 Ala Thr Trp Asp Asp Thr Leu Asp Ser Trp Val 1 5 10 <210> 1282 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC CDR1 <400> 1282 Asn Phe Ala Met His 1 5 <210> 1283 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC CDR2 <400> 1283 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1284 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC CDR3 <400> 1284 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1285 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC CDR1 <400> 1285 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1286 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC CDR2 <400> 1286 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1287 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC CDR3 <400> 1287 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1288 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC CDR1 <400> 1288 Ser Phe Ala Met His 1 5 <210> 1289 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC CDR2 <400> 1289 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1290 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC CDR3 <400> 1290 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1291 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC CDR1 <400> 1291 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1292 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC CDR2 <400> 1292 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1293 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC CDR3 <400> 1293 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1294 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC CDR1 <400> 1294 Ser Phe Ala Met His 1 5 <210> 1295 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC CDR2 <400> 1295 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1296 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC CDR3 <400> 1296 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1297 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC CDR1 <400> 1297 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1298 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC CDR2 <400> 1298 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1299 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC CDR3 <400> 1299 Ala Ala Trp Asp Asp Ser Leu Asn Val Trp Val 1 5 10 <210> 1300 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC CDR1 <400> 1300 Arg Phe Ala Met His 1 5 <210> 1301 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC CDR2 <400> 1301 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1302 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC CDR3 <400> 1302 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1303 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC CDR1 <400> 1303 Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn Pro Val Asn 1 5 10 <210> 1304 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC CDR2 <400> 1304 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1305 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC CDR3 <400> 1305 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1306 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC CDR1 <400> 1306 Ser Phe Ala Met His 1 5 <210> 1307 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC CDR2 <400> 1307 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1308 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC CDR3 <400> 1308 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1309 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC CDR1 <400> 1309 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1310 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC CDR2 <400> 1310 Ser Asn Ser Gln Arg Pro Ser 1 5 <210> 1311 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC CDR3 <400> 1311 Ala Gly Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1312 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC CDR1 <400> 1312 Arg Phe Ala Met His 1 5 <210> 1313 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC CDR2 <400> 1313 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1314 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC CDR3 <400> 1314 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1315 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC CDR1 <400> 1315 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1316 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC CDR2 <400> 1316 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1317 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC CDR3 <400> 1317 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1318 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 220 HC CDR1 <400> 1318 Asn Phe Ala Met His 1 5 <210> 1319 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.220 HC CDR2 <400> 1319 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1320 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 220 HC CDR3 <400> 1320 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1321 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC CDR1 <400> 1321 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1322 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC CDR2 <400> 1322 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1323 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC CDR3 <400> 1323 Ala Thr Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1324 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC CDR1 <400> 1324 Arg Phe Ala Met His 1 5 <210> 1325 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC CDR2 <400> 1325 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1326 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC CDR3 <400> 1326 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1327 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC CDR1 <400> 1327 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1328 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC CDR2 <400> 1328 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1329 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC CDR3 <400> 1329 Ala Thr Trp Asp Asp Ala Leu Ser Gly Trp Val 1 5 10 <210> 1330 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC CDR1 <400> 1330 Arg Phe Ala Met His 1 5 <210> 1331 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC CDR2 <400> 1331 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1332 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC CDR3 <400> 1332 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1333 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC CDR1 <400> 1333 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1334 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC CDR2 <400> 1334 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1335 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC CDR3 <400> 1335 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1336 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC CDR1 <400> 1336 Arg Phe Ala Met His 1 5 <210> 1337 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC CDR2 <400> 1337 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1338 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC CDR3 <400> 1338 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1339 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC CDR1 <400> 1339 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1340 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC CDR2 <400> 1340 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1341 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC CDR3 <400> 1341 Ala Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 1342 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC CDR1 <400> 1342 Ser Tyr Ser Met His 1 5 <210> 1343 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC CDR2 <400> 1343 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1344 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC CDR3 <400> 1344 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1345 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC CDR1 <400> 1345 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1346 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC CDR2 <400> 1346 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1347 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC CDR3 <400> 1347 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1348 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC CDR1 <400> 1348 Thr Tyr Ser Met His 1 5 <210> 1349 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC CDR2 <400> 1349 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1350 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC CDR3 <400> 1350 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1351 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC CDR1 <400> 1351 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1352 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC CDR2 <400> 1352 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1353 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC CDR3 <400> 1353 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1354 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC CDR1 <400> 1354 Asn Phe Ala Met His 1 5 <210> 1355 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC CDR2 <400> 1355 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1356 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC CDR3 <400> 1356 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1357 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC CDR1 <400> 1357 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1358 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC CDR2 <400> 1358 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1359 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC CDR3 <400> 1359 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1360 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC CDR1 <400> 1360 Asn Phe Ala Met His 1 5 <210> 1361 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC CDR2 <400> 1361 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1362 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC CDR3 <400> 1362 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1363 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC CDR1 <400> 1363 Ser Gly Ser Ser Ser Asn Val Gly Ser Asn Thr Val Asn 1 5 10 <210> 1364 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC CDR2 <400> 1364 Ser Asn Asp Gln Arg Pro Ser 1 5 <210> 1365 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC CDR3 <400> 1365 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1366 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC CDR1 <400> 1366 Ser Phe Ala Met His 1 5 <210> 1367 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC CDR2 <400> 1367 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1368 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC CDR3 <400> 1368 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1369 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC CDR1 <400> 1369 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1370 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC CDR2 <400> 1370 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1371 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC CDR3 <400> 1371 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1372 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC CDR1 <400> 1372 Arg Phe Ala Met His 1 5 <210> 1373 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC CDR2 <400> 1373 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1374 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC CDR3 <400> 1374 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1375 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC CDR1 <400> 1375 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1376 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC CDR2 <400> 1376 Ser Ser Asn Gln Arg Pro Ser 1 5 <210> 1377 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC CDR3 <400> 1377 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1378 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC CDR1 <400> 1378 Asn Phe Ala Met His 1 5 <210> 1379 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC CDR2 <400> 1379 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1380 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC CDR3 <400> 1380 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1381 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC CDR1 <400> 1381 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1382 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC CDR2 <400> 1382 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1383 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC CDR3 <400> 1383 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1384 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC CDR1 <400> 1384 Ser Phe Ala Met His 1 5 <210> 1385 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC CDR2 <400> 1385 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1386 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC CDR3 <400> 1386 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1387 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC CDR1 <400> 1387 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1388 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC CDR2 <400> 1388 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1389 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC CDR3 <400> 1389 Ala Ala Trp Asp Asp Ser Leu Asn Ala Trp Val 1 5 10 <210> 1390 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC CDR1 <400> 1390 Ser Tyr Ser Met His 1 5 <210> 1391 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC CDR2 <400> 1391 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1392 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC CDR3 <400> 1392 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1393 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 233 LC CDR1 <400> 1393 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1394 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 233 LC CDR2 <400> 1394 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1395 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 233 LC CDR3 <400> 1395 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1396 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 233 HC CDR1 <400> 1396 Arg Phe Ala Met His 1 5 <210> 1397 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 233 HC CDR2 <400> 1397 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1398 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 233 HC CDR3 <400> 1398 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1399 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC CDR1 <400> 1399 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1400 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC CDR2 <400> 1400 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1401 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC CDR3 <400> 1401 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1402 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC CDR1 <400> 1402 Arg Phe Ala Met His 1 5 <210> 1403 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC CDR2 <400> 1403 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1404 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC CDR3 <400> 1404 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1405 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC CDR1 <400> 1405 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1406 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC CDR2 <400> 1406 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1407 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC CDR3 <400> 1407 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1408 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC CDR1 <400> 1408 Ser Tyr Ala Met His 1 5 <210> 1409 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC CDR2 <400> 1409 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1410 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC CDR3 <400> 1410 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1411 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC CDR1 <400> 1411 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1412 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC CDR2 <400> 1412 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1413 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC CDR3 <400> 1413 Gly Thr Trp Asp Ser Asn Ser Glu Thr Trp Val 1 5 10 <210> 1414 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC CDR1 <400> 1414 Thr Tyr Ser Met His 1 5 <210> 1415 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC CDR2 <400> 1415 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1416 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC CDR3 <400> 1416 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1417 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC CDR1 <400> 1417 Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1418 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC CDR2 <400> 1418 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1419 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC CDR3 <400> 1419 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1420 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC CDR1 <400> 1420 Ser Phe Ala Met His 1 5 <210> 1421 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC CDR2 <400> 1421 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1422 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC CDR3 <400> 1422 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1423 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC CDR1 <400> 1423 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1424 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC CDR2 <400> 1424 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1425 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC CDR3 <400> 1425 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1426 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC CDR1 <400> 1426 Thr Tyr Ser Met His 1 5 <210> 1427 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC CDR2 <400> 1427 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1428 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC CDR3 <400> 1428 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1429 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC CDR1 <400> 1429 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Thr Val Asn 1 5 10 <210> 1430 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC CDR2 <400> 1430 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1431 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC CDR3 <400> 1431 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1432 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC CDR1 <400> 1432 Asn Phe Ala Met His 1 5 <210> 1433 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC CDR2 <400> 1433 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1434 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC CDR3 <400> 1434 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1435 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC CDR1 <400> 1435 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1436 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC CDR2 <400> 1436 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1437 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC CDR3 <400> 1437 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1438 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC CDR1 <400> 1438 Asn Phe Ala Met His 1 5 <210> 1439 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC CDR2 <400> 1439 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1440 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC CDR3 <400> 1440 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1441 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 241 LC CDR1 <400> 1441 Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn Ser Val Asn 1 5 10 <210> 1442 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 241 LC CDR2 <400> 1442 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1443 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 241 LC CDR3 <400> 1443 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1444 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 241 HC CDR1 <400> 1444 Ser Phe Ala Met His 1 5 <210> 1445 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 241 HC CDR2 <400> 1445 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1446 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 241 HC CDR3 <400> 1446 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1447 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 242 LC CDR1 <400> 1447 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Thr Val Asn 1 5 10 <210> 1448 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 242 LC CDR2 <400> 1448 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1449 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 242 LC CDR3 <400> 1449 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1450 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 242 HC CDR1 <400> 1450 Ser Phe Ala Met His 1 5 <210> 1451 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 242 HC CDR2 <400> 1451 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Glu Ser Val Lys 1 5 10 15 Gly <210> 1452 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 242 HC CDR3 <400> 1452 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1453 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 243 LC CDR1 <400> 1453 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1454 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 243 LC CDR2 <400> 1454 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1455 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 243 LC CDR3 <400> 1455 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1456 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 243 HC CDR1 <400> 1456 Ser Phe Ala Met His 1 5 <210> 1457 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 243 HC CDR2 <400> 1457 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1458 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 243 HC CDR3 <400> 1458 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1459 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC CDR1 <400> 1459 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1460 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC CDR2 <400> 1460 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1461 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC CDR3 <400> 1461 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1462 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC CDR1 <400> 1462 Asn Phe Ala Met His 1 5 <210> 1463 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC CDR2 <400> 1463 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1464 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC CDR3 <400> 1464 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1465 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC CDR1 <400> 1465 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1466 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC CDR2 <400> 1466 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1467 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC CDR3 <400> 1467 Ala Thr Trp Asp Asp Ser Leu Asn Ala Trp Val 1 5 10 <210> 1468 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC CDR1 <400> 1468 Arg Phe Ala Met His 1 5 <210> 1469 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC CDR2 <400> 1469 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1470 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC CDR3 <400> 1470 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1471 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC CDR1 <400> 1471 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1472 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC CDR2 <400> 1472 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1473 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC CDR3 <400> 1473 Ala Thr Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1474 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC CDR1 <400> 1474 Arg Phe Ala Met His 1 5 <210> 1475 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC CDR2 <400> 1475 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1476 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC CDR3 <400> 1476 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1477 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC CDR1 <400> 1477 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1478 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC CDR2 <400> 1478 Ser Asn Gln Arg Pro Ser 1 5 <210> 1479 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC CDR3 <400> 1479 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1480 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC CDR1 <400> 1480 Arg Phe Ala Met His 1 5 <210> 1481 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC CDR2 <400> 1481 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1482 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC CDR3 <400> 1482 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1483 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC CDR1 <400> 1483 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1484 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC CDR2 <400> 1484 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1485 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC CDR3 <400> 1485 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1486 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC CDR1 <400> 1486 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1487 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC CDR2 <400> 1487 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1488 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC CDR3 <400> 1488 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1489 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC CDR1 <400> 1489 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 1490 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC CDR2 <400> 1490 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 1491 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC CDR3 <400> 1491 Gln Val Trp Asp Gly Ser Ser Asp His Tyr Val 1 5 10 <210> 1492 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC CDR1 <400> 1492 Ser Tyr Ala Met Ser 1 5 <210> 1493 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC CDR2 <400> 1493 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1494 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC CDR3 <400> 1494 Leu Ser His Gly Val Val Gly Ala Gln Asp Ala Phe Asp Ile 1 5 10 <210> 1495 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC CDR1 <400> 1495 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1496 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC CDR2 <400> 1496 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1497 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC CDR3 <400> 1497 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1498 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC CDR1 <400> 1498 Ser Tyr Ala Ile Ser 1 5 <210> 1499 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC CDR2 <400> 1499 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1500 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC CDR3 <400> 1500 Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 1 5 10 <210> 1501 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC CDR1 <400> 1501 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1502 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC CDR2 <400> 1502 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1503 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC CDR3 <400> 1503 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1504 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC CDR1 <400> 1504 Asp Tyr Ala Met His 1 5 <210> 1505 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC CDR2 <400> 1505 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1506 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC CDR3 <400> 1506 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1507 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC CDR1 <400> 1507 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1508 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC CDR2 <400> 1508 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1509 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC CDR3 <400> 1509 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 1510 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC CDR1 <400> 1510 Asp Tyr Ala Met His 1 5 <210> 1511 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC CDR2 <400> 1511 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1512 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC CDR3 <400> 1512 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1513 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC CDR1 <400> 1513 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1514 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC CDR2 <400> 1514 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1515 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC CDR3 <400> 1515 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1516 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC CDR1 <400> 1516 Asp Tyr Ala Met His 1 5 <210> 1517 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC CDR2 <400> 1517 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1518 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC CDR3 <400> 1518 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1519 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC CDR1 <400> 1519 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 1520 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC CDR2 <400> 1520 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 1521 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC CDR3 <400> 1521 Gln Val Trp Asp Ser Ser Ser Asp His Pro Val 1 5 10 <210> 1522 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC CDR1 <400> 1522 Asp Tyr Ala Met His 1 5 <210> 1523 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC CDR2 <400> 1523 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1524 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC CDR3 <400> 1524 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1525 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC CDR1 <400> 1525 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 1526 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC CDR2 <400> 1526 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 1527 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC CDR3 <400> 1527 Gln Ser Tyr Asp Ser Ser Asn His Ala Val 1 5 10 <210> 1528 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC CDR1 <400> 1528 Asp Tyr Ala Met His 1 5 <210> 1529 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC CDR2 <400> 1529 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1530 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC CDR3 <400> 1530 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1531 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC CDR1 <400> 1531 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1532 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC CDR2 <400> 1532 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1533 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC CDR3 <400> 1533 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1534 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC CDR1 <400> 1534 Asp Tyr Ala Met His 1 5 <210> 1535 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC CDR2 <400> 1535 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1536 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC CDR3 <400> 1536 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1537 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC CDR1 <400> 1537 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1538 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC CDR2 <400> 1538 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1539 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC CDR3 <400> 1539 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1540 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC CDR1 <400> 1540 Asp Tyr Ala Met His 1 5 <210> 1541 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC CDR2 <400> 1541 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1542 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC CDR3 <400> 1542 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1543 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC CDR1 <400> 1543 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1544 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC CDR2 <400> 1544 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1545 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC CDR3 <400> 1545 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1546 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC CDR1 <400> 1546 Asp Tyr Ala Met His 1 5 <210> 1547 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC CDR2 <400> 1547 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1548 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC CDR3 <400> 1548 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1549 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC CDR1 <400> 1549 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1550 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC CDR2 <400> 1550 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1551 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC CDR3 <400> 1551 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1552 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC CDR1 <400> 1552 Asp Tyr Ala Met His 1 5 <210> 1553 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC CDR2 <400> 1553 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1554 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC CDR3 <400> 1554 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1555 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC CDR1 <400> 1555 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1556 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC CDR2 <400> 1556 Thr Asn Asn Gln Arg Pro Ser 1 5 <210> 1557 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC CDR3 <400> 1557 Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val 1 5 10 <210> 1558 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC CDR1 <400> 1558 Asp Tyr Ala Met His 1 5 <210> 1559 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC CDR2 <400> 1559 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1560 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC CDR3 <400> 1560 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1561 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC CDR1 <400> 1561 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1562 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC CDR2 <400> 1562 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 1563 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC CDR3 <400> 1563 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val 1 5 10 <210> 1564 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 261 HC CDR1 <400> 1564 Asp Tyr Ala Met His 1 5 <210> 1565 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.261 HC CDR2 <400> 1565 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1566 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 261 HC CDR3 <400> 1566 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1567 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC CDR1 <400> 1567 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1568 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC CDR2 <400> 1568 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1569 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC CDR3 <400> 1569 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Tyr Val 1 5 10 <210> 1570 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC CDR1 <400> 1570 Asp Tyr Ala Met His 1 5 <210> 1571 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC CDR2 <400> 1571 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1572 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC CDR3 <400> 1572 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1573 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC CDR1 <400> 1573 Ser Gly Ser Ser Pro Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1574 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC CDR2 <400> 1574 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1575 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC CDR3 <400> 1575 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val 1 5 10 <210> 1576 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC CDR1 <400> 1576 Asp Tyr Ala Met His 1 5 <210> 1577 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC CDR2 <400> 1577 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1578 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC CDR3 <400> 1578 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1579 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC CDR1 <400> 1579 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1580 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC CDR2 <400> 1580 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1581 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC CDR3 <400> 1581 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val 1 5 10 <210> 1582 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC CDR1 <400> 1582 Asp Tyr Ala Met His 1 5 <210> 1583 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC CDR2 <400> 1583 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1584 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC CDR3 <400> 1584 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1585 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC CDR1 <400> 1585 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1586 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC CDR2 <400> 1586 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1587 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC CDR3 <400> 1587 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val 1 5 10 <210> 1588 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC CDR1 <400> 1588 Ser Asn Tyr Met Thr 1 5 <210> 1589 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC CDR2 <400> 1589 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1590 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC CDR3 <400> 1590 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1591 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC CDR1 <400> 1591 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 1592 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC CDR2 <400> 1592 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 1593 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC CDR3 <400> 1593 Gln Val Arg Asp Ser Ser Ser Asp His Pro Val 1 5 10 <210> 1594 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC CDR1 <400> 1594 Ser Asn Tyr Met Thr 1 5 <210> 1595 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC CDR2 <400> 1595 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1596 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC CDR3 <400> 1596 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1597 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC CDR1 <400> 1597 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1598 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC CDR2 <400> 1598 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1599 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC CDR3 <400> 1599 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val 1 5 10 <210> 1600 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC CDR1 <400> 1600 Ser Asn Tyr Met Thr 1 5 <210> 1601 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC CDR2 <400> 1601 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1602 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC CDR3 <400> 1602 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1603 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC CDR1 <400> 1603 Thr Gly Ser Asp Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1604 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC CDR2 <400> 1604 Asn Asn Asn Asn Arg Pro Ser 1 5 <210> 1605 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC CDR3 <400> 1605 Gln Ser Ser Asp Ser Gly Leu Thr Gly Trp Val 1 5 10 <210> 1606 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC CDR1 <400> 1606 Ser Asn Tyr Met Thr 1 5 <210> 1607 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC CDR2 <400> 1607 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1608 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC CDR3 <400> 1608 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1609 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC CDR1 <400> 1609 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1610 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC CDR2 <400> 1610 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1611 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC CDR3 <400> 1611 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1612 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC CDR1 <400> 1612 Ser Asn Tyr Met Thr 1 5 <210> 1613 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC CDR2 <400> 1613 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1614 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC CDR3 <400> 1614 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1615 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC CDR1 <400> 1615 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 1616 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC CDR2 <400> 1616 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 1617 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC CDR3 <400> 1617 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 1618 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC CDR1 <400> 1618 Ser Asn Tyr Met Thr 1 5 <210> 1619 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC CDR2 <400> 1619 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1620 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC CDR3 <400> 1620 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1621 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC CDR1 <400> 1621 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1622 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC CDR2 <400> 1622 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1623 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC CDR3 <400> 1623 Ser Ser Tyr Ala Gly Ser Asn Asn Leu Val 1 5 10 <210> 1624 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC CDR1 <400> 1624 Ser Asn Tyr Met Thr 1 5 <210> 1625 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC CDR2 <400> 1625 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1626 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC CDR3 <400> 1626 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1627 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC CDR1 <400> 1627 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1628 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC CDR2 <400> 1628 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1629 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC CDR3 <400> 1629 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1630 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC CDR1 <400> 1630 Ser Asn Tyr Met Thr 1 5 <210> 1631 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC CDR2 <400> 1631 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1632 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC CDR3 <400> 1632 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1633 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC CDR1 <400> 1633 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 1634 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC CDR2 <400> 1634 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 1635 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC CDR3 <400> 1635 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 1636 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC CDR1 <400> 1636 Ser Asn Tyr Met Thr 1 5 <210> 1637 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC CDR2 <400> 1637 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1638 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC CDR3 <400> 1638 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1639 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC CDR1 <400> 1639 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1640 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC CDR2 <400> 1640 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1641 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC CDR3 <400> 1641 Gln Ser Tyr Asp Ser Ser Leu Gly Val Val 1 5 10 <210> 1642 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC CDR1 <400> 1642 Ser Asn Tyr Met Thr 1 5 <210> 1643 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC CDR2 <400> 1643 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1644 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC CDR3 <400> 1644 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1645 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC CDR1 <400> 1645 Gly Gly Asn Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1646 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC CDR2 <400> 1646 Ser Asn Asn Leu Arg Pro Ser 1 5 <210> 1647 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC CDR3 <400> 1647 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 1648 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC CDR1 <400> 1648 Ser Asn Tyr Met Thr 1 5 <210> 1649 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC CDR2 <400> 1649 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1650 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC CDR3 <400> 1650 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1651 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC CDR1 <400> 1651 Ser Gly Ser Ser Ser Asn Ile Gly Gly Ser Asp Val Gly 1 5 10 <210> 1652 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC CDR2 <400> 1652 Lys Ser Asn Gln Arg Pro Ser 1 5 <210> 1653 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC CDR3 <400> 1653 Ala Thr Trp Asp Asp Arg Leu Asn Trp Val 1 5 10 <210> 1654 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC CDR1 <400> 1654 Ser Asn Tyr Met Thr 1 5 <210> 1655 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC CDR2 <400> 1655 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1656 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC CDR3 <400> 1656 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1657 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC CDR1 <400> 1657 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 1658 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC CDR2 <400> 1658 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 1659 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC CDR3 <400> 1659 Gln Gln Ser Tyr Ser Thr Pro Phe Thr 1 5 <210> 1660 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC CDR1 <400> 1660 Asn Tyr Tyr Met His 1 5 <210> 1661 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC CDR2 <400> 1661 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1662 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC CDR3 <400> 1662 Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr 1 5 10 <210> 1663 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC CDR1 <400> 1663 Gln Ala Gly Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 1664 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC CDR2 <400> 1664 Lys Ala Ser Ser Leu Glu Ser 1 5 <210> 1665 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC CDR3 <400> 1665 Gln Gln Ala His Ser Phe Pro Phe Thr 1 5 <210> 1666 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC CDR1 <400> 1666 Ser Tyr Tyr Met His 1 5 <210> 1667 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC CDR2 <400> 1667 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1668 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC CDR3 <400> 1668 Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr 1 5 10 <210> 1669 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC CDR1 <400> 1669 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 1670 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC CDR2 <400> 1670 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 1671 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC CDR3 <400> 1671 Gln Gln Ser Tyr Ser Thr Leu Pro Thr 1 5 <210> 1672 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC CDR1 <400> 1672 Ser Tyr Tyr Met His 1 5 <210> 1673 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC CDR2 <400> 1673 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1674 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC CDR3 <400> 1674 Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr 1 5 10 <210> 1675 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC CDR1 <400> 1675 Thr Gly Ser Ser Ser Asn Thr Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1676 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC CDR2 <400> 1676 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1677 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC CDR3 <400> 1677 Ala Ala Trp Asp Asp Ser Leu Asn Gly Gly Val 1 5 10 <210> 1678 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC CDR1 <400> 1678 Ser Asn Tyr Met Ser 1 5 <210> 1679 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC CDR2 <400> 1679 Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1680 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC CDR3 <400> 1680 Asp Leu Ile Val Tyr Gly Met Asp Val 1 5 <210> 1681 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 281 LC CDR1 <400> 1681 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1682 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 281 LC CDR2 <400> 1682 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1683 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 281 LC CDR3 <400> 1683 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1684 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 281 HC CDR1 <400> 1684 Ser Asn Tyr Met Ser 1 5 <210> 1685 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.281 HC CDR2 <400> 1685 Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1686 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 281 HC CDR3 <400> 1686 Asp Leu Ile Val Tyr Gly Met Asp Val 1 5 <210> 1687 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC CDR1 <400> 1687 Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1688 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC CDR2 <400> 1688 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1689 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC CDR3 <400> 1689 Ala Ala Trp Asp Asp Ser Leu Asn Gly Gly Val 1 5 10 <210> 1690 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC CDR1 <400> 1690 Ser Asn Tyr Met Ser 1 5 <210> 1691 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC CDR2 <400> 1691 Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1692 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC CDR3 <400> 1692 Asp Leu Ile Val Tyr Gly Met Asp Val 1 5 <210> 1693 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC CDR1 <400> 1693 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 1694 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC CDR2 <400> 1694 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 1695 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC CDR3 <400> 1695 Gln Gln Tyr Gly Ser Ser Pro Pro Tyr Thr 1 5 10 <210> 1696 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC CDR1 <400> 1696 Ser Asn Tyr Met Ser 1 5 <210> 1697 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC CDR2 <400> 1697 Val Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1698 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC CDR3 <400> 1698 Asp Leu Arg Gly Val Leu Asp Tyr 1 5 <210> 1699 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC CDR1 <400> 1699 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1700 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC CDR2 <400> 1700 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1701 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC CDR3 <400> 1701 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1702 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC CDR1 <400> 1702 Ser Asn Tyr Met Ser 1 5 <210> 1703 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC CDR2 <400> 1703 Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1704 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC CDR3 <400> 1704 Gly His Val Asp Ile Pro Tyr Gly Met Asp Val 1 5 10 <210> 1705 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC CDR1 <400> 1705 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1706 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC CDR2 <400> 1706 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1707 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC CDR3 <400> 1707 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1708 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC CDR1 <400> 1708 Ser Tyr Ala Ile Ser 1 5 <210> 1709 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC CDR2 <400> 1709 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1710 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC CDR3 <400> 1710 Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp Pro 1 5 10 15 <210> 1711 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC CDR1 <400> 1711 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1712 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC CDR2 <400> 1712 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1713 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC CDR3 <400> 1713 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1714 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC CDR1 <400> 1714 Ser Tyr Ala Ile Ser 1 5 <210> 1715 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC CDR2 <400> 1715 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1716 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC CDR3 <400> 1716 Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp Pro 1 5 10 15 <210> 1717 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC CDR1 <400> 1717 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1718 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC CDR2 <400> 1718 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1719 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC CDR3 <400> 1719 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1720 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC CDR1 <400> 1720 Ser Tyr Ala Ile Ser 1 5 <210> 1721 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC CDR2 <400> 1721 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1722 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC CDR3 <400> 1722 Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 1 5 10 <210> 1723 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC CDR1 <400> 1723 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 1724 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC CDR2 <400> 1724 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 1725 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC CDR3 <400> 1725 Gln Ser Tyr Asp Ser Ser Asn His Trp Val 1 5 10 <210> 1726 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC CDR1 <400> 1726 Ser Tyr Ala Met His 1 5 <210> 1727 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC CDR2 <400> 1727 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1728 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC CDR3 <400> 1728 Ala Asn Leu Gly Tyr Cys Thr Asn Gly Val Cys Ala Pro Ser Gly Gly 1 5 10 15 <210> 1729 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC CDR1 <400> 1729 Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1730 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC CDR2 <400> 1730 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1731 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC CDR3 <400> 1731 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 1732 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC CDR1 <400> 1732 Asp Tyr Ala Met His 1 5 <210> 1733 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC CDR2 <400> 1733 Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1734 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC CDR3 <400> 1734 Asn Leu Arg Tyr Phe Asp Trp Leu Leu Gly Asp Asp Ala Phe Asp Ile 1 5 10 15 <210> 1735 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC CDR1 <400> 1735 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1736 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC CDR2 <400> 1736 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1737 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC CDR3 <400> 1737 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1738 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC CDR1 <400> 1738 Ser Asn Tyr Met Thr 1 5 <210> 1739 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC CDR2 <400> 1739 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1740 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC CDR3 <400> 1740 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1741 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.1 LC variable region <400> 1741 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1742 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.1 HC variable region <400> 1742 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu 100 105 110 Asp Ala Phe Asp Ile Trp Gly Gly Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 1743 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.2 LC variable region <400> 1743 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Val Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro His 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1744 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.2 HC variable region <400> 1744 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu 100 105 110 Asp Ala Phe Asp Ile Trp Gly Gly Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 1745 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.3 LC variable region <400> 1745 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1746 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.3 HC variable region <400> 1746 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr 100 105 110 Ser Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1747 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.4 LC variable region <400> 1747 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asp Leu Pro Ile 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1748 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.4 HC variable region <400> 1748 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr 100 105 110 Ser Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1749 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.5 LC variable region <400> 1749 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1750 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.5 HC variable region <400> 1750 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr 100 105 110 Ser Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1751 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.6 LC variable region <400> 1751 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1752 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.6 HC variable region <400> 1752 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1753 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.7 LC variable region <400> 1753 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1754 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.7 HC variable region <400> 1754 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1755 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC variable region <400> 1755 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1756 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC variable region <400> 1756 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1757 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.9 LC variable region <400> 1757 Glu Leu Glu Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1758 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.9 HC variable region <400> 1758 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1759 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC variable region <400> 1759 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1760 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC variable region <400> 1760 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1761 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.11 LC variable region <400> 1761 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1762 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.11 HC variable region <400> 1762 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1763 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.12 LC variable region <400> 1763 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1764 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.12 HC variable region <400> 1764 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1765 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.13 LC variable region <400> 1765 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Gly Asn Tyr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1766 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.13 HC variable region <400> 1766 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1767 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.14 LC variable region <400> 1767 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 20 25 30 Tyr Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Arg Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1768 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.14 HC variable region <400> 1768 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1769 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.15 LC variable region <400> 1769 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1770 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.15 HC variable region <400> 1770 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1771 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC variable region <400> 1771 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1772 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC variable region <400> 1772 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1773 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC variable region <400> 1773 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1774 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC variable region <400> 1774 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1775 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.18 LC variable region <400> 1775 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1776 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.18 HC variable region <400> 1776 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1777 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC variable region <400> 1777 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1778 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.19 HC variable region <400> 1778 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1779 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.20 LC variable region <400> 1779 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1780 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.20 HC variable region <400> 1780 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1781 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC variable region <400> 1781 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1782 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC variable region <400> 1782 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1783 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.22 LC variable region <400> 1783 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1784 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.22 HC variable region <400> 1784 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1785 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC variable region <400> 1785 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1786 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.23 HC variable region <400> 1786 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1787 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.24 LC variable region <400> 1787 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1788 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.24 HC variable region <400> 1788 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1789 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC variable region <400> 1789 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1790 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC variable region <400> 1790 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1791 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC variable region <400> 1791 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1792 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC variable region <400> 1792 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1793 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC variable region <400> 1793 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1794 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC variable region <400> 1794 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1795 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC variable region <400> 1795 Glu Leu Glu Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1796 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC variable region <400> 1796 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1797 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC variable region <400> 1797 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1798 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC variable region <400> 1798 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1799 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.30 LC variable region <400> 1799 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1800 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.30 HC variable region <400> 1800 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1801 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.31 LC variable region <400> 1801 Glu Leu Gly Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 20 25 30 Tyr Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1802 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.31 HC variable region <400> 1802 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1803 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC variable region <400> 1803 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1804 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC variable region <400> 1804 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1805 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC variable region <400> 1805 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1806 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC variable region <400> 1806 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1807 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC variable region <400> 1807 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1808 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC variable region <400> 1808 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1809 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC variable region <400> 1809 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1810 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC variable region <400> 1810 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1811 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC variable region <400> 1811 Glu Leu Val Val Thr Gln Pro Ser Ala Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1812 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC variable region <400> 1812 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1813 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC variable region <400> 1813 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1814 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC variable region <400> 1814 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1815 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC variable region <400> 1815 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1816 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.38 HC variable region <400> 1816 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1817 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC variable region <400> 1817 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1818 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC variable region <400> 1818 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1819 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.40 LC variable region <400> 1819 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1820 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.40 HC variable region <400> 1820 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1821 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC variable region <400> 1821 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1822 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC variable region <400> 1822 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1823 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC variable region <400> 1823 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1824 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC variable region <400> 1824 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1825 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC variable region <400> 1825 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1826 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC variable region <400> 1826 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1827 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC variable region <400> 1827 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Val Thr Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1828 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC variable region <400> 1828 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Arg Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Pro Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1829 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC variable region <400> 1829 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1830 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC variable region <400> 1830 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1831 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC variable region <400> 1831 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1832 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC variable region <400> 1832 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1833 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC variable region <400> 1833 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1834 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC variable region <400> 1834 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1835 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC variable region <400> 1835 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1836 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC variable region <400> 1836 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Ser His Tyr 20 25 30 Phe Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly 100 105 110 Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1837 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.49 LC variable region <400> 1837 Glu Leu Ala Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1838 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.49 HC variable region <400> 1838 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1839 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC variable region <400> 1839 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1840 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC variable region <400> 1840 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1841 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC variable region <400> 1841 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1842 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC variable region <400> 1842 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1843 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.52 LC variable region <400> 1843 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1844 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.52 HC variable region <400> 1844 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1845 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC variable region <400> 1845 Glu Leu Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Gly Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Ala Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1846 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC variable region <400> 1846 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1847 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC variable region <400> 1847 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Ala Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr His Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1848 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC variable region <400> 1848 Arg Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1849 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC variable region <400> 1849 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser 85 90 95 Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1850 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC variable region <400> 1850 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1851 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC variable region <400> 1851 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 1852 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC variable region <400> 1852 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1853 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.57 LC variable region <400> 1853 Glu Leu Val Met Thr Gln Ser Pro Gly Ile Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1854 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.57 HC variable region <400> 1854 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1855 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.58 LC variable region <400> 1855 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1856 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.58 HC variable region <400> 1856 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1857 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC variable region <400> 1857 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1858 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC variable region <400> 1858 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1859 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC variable region <400> 1859 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Pro Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1860 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.60 HC variable region <400> 1860 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1861 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC variable region <400> 1861 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Ser 85 90 95 Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1862 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC variable region <400> 1862 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1863 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC variable region <400> 1863 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1864 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC variable region <400> 1864 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1865 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC variable region <400> 1865 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1866 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC variable region <400> 1866 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Val Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1867 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC variable region <400> 1867 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1868 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC variable region <400> 1868 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1869 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC variable region <400> 1869 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Ser Ala Thr Leu Ala Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Phe Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 1870 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC variable region <400> 1870 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1871 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC variable region <400> 1871 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1872 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC variable region <400> 1872 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1873 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC variable region <400> 1873 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1874 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC variable region <400> 1874 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1875 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC variable region <400> 1875 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Pro Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 1876 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC variable region <400> 1876 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Val Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1877 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC variable region <400> 1877 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile His Ala Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Val Glu 65 70 75 80 Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asp Ser Leu 85 90 95 Ser Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1878 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC variable region <400> 1878 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1879 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.70 LC variable region <400> 1879 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser 85 90 95 Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1880 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.70 HC variable region <400> 1880 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1881 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC variable region <400> 1881 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1882 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC variable region <400> 1882 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1883 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC variable region <400> 1883 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met 35 40 45 Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 65 70 75 80 Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser Ser 85 90 95 Thr Leu Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 <210> 1884 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC variable region <400> 1884 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1885 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC variable region <400> 1885 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Ser Ala Thr Leu Ala Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Phe Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 1886 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC variable region <400> 1886 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Pro Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1887 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC variable region <400> 1887 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1888 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC variable region <400> 1888 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1889 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC variable region <400> 1889 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1890 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC variable region <400> 1890 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1891 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC variable region <400> 1891 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1892 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC variable region <400> 1892 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1893 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC variable region <400> 1893 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1894 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC variable region <400> 1894 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1895 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC variable region <400> 1895 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1896 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC variable region <400> 1896 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1897 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC variable region <400> 1897 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Ser 85 90 95 Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1898 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC variable region <400> 1898 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1899 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC variable region <400> 1899 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1900 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC variable region <400> 1900 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1901 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC variable region <400> 1901 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1902 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC variable region <400> 1902 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1903 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC variable region <400> 1903 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1904 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC variable region <400> 1904 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1905 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC variable region <400> 1905 Glu Leu Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1906 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC variable region <400> 1906 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1907 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC variable region <400> 1907 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1908 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC variable region <400> 1908 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Val Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1909 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC variable region <400> 1909 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1910 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC variable region <400> 1910 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1911 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC variable region <400> 1911 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Arg Ala Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1912 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC variable region <400> 1912 Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1913 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC variable region <400> 1913 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1914 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC variable region <400> 1914 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1915 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC variable region <400> 1915 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser 85 90 95 Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1916 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC variable region <400> 1916 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 1917 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC variable region <400> 1917 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Arg Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1918 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC variable region <400> 1918 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1919 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC variable region <400> 1919 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1920 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC variable region <400> 1920 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1921 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC variable region <400> 1921 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1922 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC variable region <400> 1922 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ala Gln 1 5 10 15 Thr Leu Arg Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Phe Ser 115 120 125 <210> 1923 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC variable region <400> 1923 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1924 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC variable region <400> 1924 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1925 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC variable region <400> 1925 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Arg Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1926 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC variable region <400> 1926 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Val Asp Val Trp Gly Gin Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1927 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC variable region <400> 1927 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1928 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC variable region <400> 1928 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1929 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC variable region <400> 1929 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1930 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC variable region <400> 1930 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1931 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.96 LC variable region <400> 1931 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1932 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.96 HC variable region <400> 1932 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1933 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC variable region <400> 1933 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1934 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC variable region <400> 1934 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Ser Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1935 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.98 LC variable region <400> 1935 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1936 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.98 HC variable region <400> 1936 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1937 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC variable region <400> 1937 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1938 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC variable region <400> 1938 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1939 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC variable region <400> 1939 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1940 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.100 HC variable region <400> 1940 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1941 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.101 LC variable region <400> 1941 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1942 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.101 HC variable region <400> 1942 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1943 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC variable region <400> 1943 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1944 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC variable region <400> 1944 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1945 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC variable region <400> 1945 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1946 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC variable region <400> 1946 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1947 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC variable region <400> 1947 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1948 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC variable region <400> 1948 Gln Val Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1949 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC variable region <400> 1949 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1950 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC variable region <400> 1950 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1951 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC variable region <400> 1951 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1952 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC variable region <400> 1952 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1953 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC variable region <400> 1953 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1954 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC variable region <400> 1954 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1955 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC variable region <400> 1955 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1956 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC variable region <400> 1956 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1957 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC variable region <400> 1957 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1958 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC variable region <400> 1958 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1959 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC variable region <400> 1959 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1960 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.110 HC variable region <400> 1960 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1961 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC variable region <400> 1961 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1962 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC variable region <400> 1962 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1963 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC variable region <400> 1963 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1964 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC variable region <400> 1964 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1965 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC variable region <400> 1965 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Ile Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1966 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC variable region <400> 1966 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1967 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC variable region <400> 1967 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1968 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC variable region <400> 1968 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1969 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC variable region <400> 1969 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1970 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC variable region <400> 1970 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1971 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC variable region <400> 1971 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1972 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC variable region <400> 1972 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1973 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC variable region <400> 1973 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1974 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC variable region <400> 1974 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1975 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC variable region <400> 1975 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1976 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC variable region <400> 1976 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1977 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC variable region <400> 1977 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1978 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC variable region <400> 1978 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1979 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.120 LC variable region <400> 1979 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1980 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.120 HC variable region <400> 1980 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Thr Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1981 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC variable region <400> 1981 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1982 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC variable region <400> 1982 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1983 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC variable region <400> 1983 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1984 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC variable region <400> 1984 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1985 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC variable region <400> 1985 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1986 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC variable region <400> 1986 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1987 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC variable region <400> 1987 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1988 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC variable region <400> 1988 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ala Gln 1 5 10 15 Thr Leu Arg Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Phe Ser 115 120 125 <210> 1989 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC variable region <400> 1989 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1990 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC variable region <400> 1990 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1991 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC variable region <400> 1991 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1992 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC variable region <400> 1992 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1993 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC variable region <400> 1993 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1994 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC variable region <400> 1994 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ala Gln 1 5 10 15 Thr Leu Arg Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Phe Ser 115 120 125 <210> 1995 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC variable region <400> 1995 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn 20 25 30 Phe Val Ser Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1996 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.128 HC variable region <400> 1996 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1997 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC variable region <400> 1997 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Ser Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Asn Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1998 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC variable region <400> 1998 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1999 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.130 LC variable region <400> 1999 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2000 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.130 HC variable region <400> 2000 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2001 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC variable region <400> 2001 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2002 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC variable region <400> 2002 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2003 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC variable region <400> 2003 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2004 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC variable region <400> 2004 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2005 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC variable region <400> 2005 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2006 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC variable region <400> 2006 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2007 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC variable region <400> 2007 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2008 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC variable region <400> 2008 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2009 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC variable region <400> 2009 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2010 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC variable region <400> 2010 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2011 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC variable region <400> 2011 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2012 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC variable region <400> 2012 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2013 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC variable region <400> 2013 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2014 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC variable region <400> 2014 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2015 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC variable region <400> 2015 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2016 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC variable region <400> 2016 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2017 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC variable region <400> 2017 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2018 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC variable region <400> 2018 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr His Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2019 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.140 LC variable region <400> 2019 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2020 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.140 HC variable region <400> 2020 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Ser Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2021 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC variable region <400> 2021 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2022 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC variable region <400> 2022 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2023 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC variable region <400> 2023 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2024 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC variable region <400> 2024 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2025 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC variable region <400> 2025 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2026 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC variable region <400> 2026 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2027 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC variable region <400> 2027 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2028 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC variable region <400> 2028 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2029 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC variable region <400> 2029 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2030 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC variable region <400> 2030 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2031 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC variable region <400> 2031 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2032 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC variable region <400> 2032 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2033 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC variable region <400> 2033 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2034 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC variable region <400> 2034 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Phe Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2035 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC variable region <400> 2035 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2036 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC variable region <400> 2036 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2037 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC variable region <400> 2037 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2038 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC variable region <400> 2038 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2039 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC variable region <400> 2039 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2040 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC variable region <400> 2040 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2041 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC variable region <400> 2041 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2042 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC variable region <400> 2042 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2043 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC variable region <400> 2043 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2044 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC variable region <400> 2044 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2045 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC variable region <400> 2045 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2046 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC variable region <400> 2046 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2047 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC variable region <400> 2047 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2048 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC variable region <400> 2048 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2049 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC variable region <400> 2049 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2050 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC variable region <400> 2050 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2051 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC variable region <400> 2051 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2052 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC variable region <400> 2052 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2053 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC variable region <400> 2053 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2054 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC variable region <400> 2054 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2055 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC variable region <400> 2055 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2056 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC variable region <400> 2056 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2057 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC variable region <400> 2057 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2058 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC variable region <400> 2058 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2059 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.160 LC variable region <400> 2059 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2060 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.160 HC variable region <400> 2060 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2061 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC variable region <400> 2061 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2062 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC variable region <400> 2062 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2063 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC variable region <400> 2063 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2064 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC variable region <400> 2064 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2065 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC variable region <400> 2065 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2066 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC variable region <400> 2066 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2067 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC variable region <400> 2067 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2068 <211> 133 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC variable region <400> 2068 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Pro Arg Asp His Gly His Arg Leu Leu 115 120 125 Ser Phe His Gln Gly 130 <210> 2069 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC variable region <400> 2069 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2070 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC variable region <400> 2070 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2071 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC variable region <400> 2071 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2072 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC variable region <400> 2072 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2073 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC variable region <400> 2073 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2074 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC variable region <400> 2074 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2075 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC variable region <400> 2075 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2076 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC variable region <400> 2076 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2077 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC variable region <400> 2077 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2078 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC variable region <400> 2078 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2079 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC variable region <400> 2079 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2080 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC variable region <400> 2080 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2081 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC variable region <400> 2081 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2082 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC variable region <400> 2082 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2083 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.172 LC variable region <400> 2083 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Ala Leu 100 105 110 <210> 2084 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC variable region <400> 2084 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Pro Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2085 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC variable region <400> 2085 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2086 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC variable region <400> 2086 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2087 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC variable region <400> 2087 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2088 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC variable region <400> 2088 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2089 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC variable region <400> 2089 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2090 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC variable region <400> 2090 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2091 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC variable region <400> 2091 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2092 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC variable region <400> 2092 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2093 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC variable region <400> 2093 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2094 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC variable region <400> 2094 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2095 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC variable region <400> 2095 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2096 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC variable region <400> 2096 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2097 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC variable region <400> 2097 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2098 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC variable region <400> 2098 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2099 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC variable region <400> 2099 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2100 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC variable region <400> 2100 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2101 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC variable region <400> 2101 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2102 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC variable region <400> 2102 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2103 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC variable region <400> 2103 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2104 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC variable region <400> 2104 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2105 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC variable region <400> 2105 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2106 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC variable region <400> 2106 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2107 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC variable region <400> 2107 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Arg Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2108 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC variable region <400> 2108 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2109 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC variable region <400> 2109 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2110 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC variable region <400> 2110 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2111 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC variable region <400> 2111 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2112 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC variable region <400> 2112 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2113 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC variable region <400> 2113 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2114 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC variable region <400> 2114 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2115 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC variable region <400> 2115 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2116 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC variable region <400> 2116 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2117 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC variable region <400> 2117 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2118 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC variable region <400> 2118 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2119 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC variable region <400> 2119 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2120 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC variable region <400> 2120 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2121 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.191 LC variable region <400> 2121 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2122 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.191 HC variable region <400> 2122 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2123 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC variable region <400> 2123 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2124 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC variable region <400> 2124 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2125 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC variable region <400> 2125 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2126 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC variable region <400> 2126 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2127 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC variable region <400> 2127 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2128 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC variable region <400> 2128 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2129 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC variable region <400> 2129 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asp Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2130 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC variable region <400> 2130 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Thr Arg Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Leu Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Gly Ile Ala Val Ala Gly Thr Pro Ile Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2131 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC variable region <400> 2131 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2132 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC variable region <400> 2132 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 2133 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC variable region <400> 2133 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2134 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC variable region <400> 2134 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Glu Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 2135 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC variable region <400> 2135 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Ala Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2136 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC variable region <400> 2136 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 2137 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC variable region <400> 2137 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2138 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC variable region <400> 2138 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Glu Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 2139 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC variable region <400> 2139 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2140 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC variable region <400> 2140 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 2141 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC variable region <400> 2141 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2142 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC variable region <400> 2142 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 2143 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC variable region <400> 2143 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2144 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC variable region <400> 2144 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 2145 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC variable region <400> 2145 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2146 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC variable region <400> 2146 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2147 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC variable region <400> 2147 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2148 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC variable region <400> 2148 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2149 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC variable region <400> 2149 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2150 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC variable region <400> 2150 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2151 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC variable region <400> 2151 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2152 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC variable region <400> 2152 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2153 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC variable region <400> 2153 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ala Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2154 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC variable region <400> 2154 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2155 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC variable region <400> 2155 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2156 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC variable region <400> 2156 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2157 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC variable region <400> 2157 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Ala Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2158 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC variable region <400> 2158 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2159 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC variable region <400> 2159 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2160 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC variable region <400> 2160 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2161 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC variable region <400> 2161 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Gly Asn 20 25 30 Thr Val Asn Trp Phe Gln Gln Leu Pro Gly Ala Val Pro Lys Leu Leu 35 40 45 Val Tyr Gly Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2162 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC variable region <400> 2162 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2163 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC variable region <400> 2163 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Glu Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2164 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC variable region <400> 2164 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Arg Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2165 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC variable region <400> 2165 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2166 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC variable region <400> 2166 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2167 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC variable region <400> 2167 Glu Leu Met Leu Thr Gln Pro His Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Thr Leu 85 90 95 Asp Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2168 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC variable region <400> 2168 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Pro Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2169 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC variable region <400> 2169 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2170 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC variable region <400> 2170 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2171 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC variable region <400> 2171 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2172 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC variable region <400> 2172 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2173 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC variable region <400> 2173 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Val Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2174 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC variable region <400> 2174 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2175 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC variable region <400> 2175 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Ser Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn 20 25 30 Pro Val Asn Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asn Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2176 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC variable region <400> 2176 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2177 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC variable region <400> 2177 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Phe Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Val Ser 50 55 60 Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Gly Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2178 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC variable region <400> 2178 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2179 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC variable region <400> 2179 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2180 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.220 HC variable region <400> 2180 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Pro Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2181 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC variable region <400> 2181 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2182 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC variable region <400> 2182 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2183 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC variable region <400> 2183 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ala Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2184 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC variable region <400> 2184 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2185 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC variable region <400> 2185 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2186 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC variable region <400> 2186 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2187 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC variable region <400> 2187 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2188 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC variable region <400> 2188 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2189 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC variable region <400> 2189 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2190 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC variable region <400> 2190 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2191 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC variable region <400> 2191 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2192 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC variable region <400> 2192 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2193 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC variable region <400> 2193 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2194 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC variable region <400> 2194 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2195 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC variable region <400> 2195 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Leu Ser Cys Ser Gly Ser Ser Ser Asn Val Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2196 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC variable region <400> 2196 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2197 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC variable region <400> 2197 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2198 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC variable region <400> 2198 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2199 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC variable region <400> 2199 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2200 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC variable region <400> 2200 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2201 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC variable region <400> 2201 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2202 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC variable region <400> 2202 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2203 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC variable region <400> 2203 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2204 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC variable region <400> 2204 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2205 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.233 LC variable region <400> 2205 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2206 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.233 HC variable region <400> 2206 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2207 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC variable region <400> 2207 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2208 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC variable region <400> 2208 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2209 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC variable region <400> 2209 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2210 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC variable region <400> 2210 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2211 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC variable region <400> 2211 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Asn Ser 85 90 95 Glu Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2212 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC variable region <400> 2212 Glu Val Gln Leu Leu Glu Ser Arg Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2213 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC variable region <400> 2213 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2214 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC variable region <400> 2214 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2215 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC variable region <400> 2215 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2216 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC variable region <400> 2216 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2217 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC variable region <400> 2217 Asp Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Met Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2218 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC variable region <400> 2218 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2219 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC variable region <400> 2219 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2220 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC variable region <400> 2220 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Pro Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2221 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.241 LC variable region <400> 2221 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn 20 25 30 Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Leu Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2222 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.241 HC variable region <400> 2222 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2223 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.242 LC variable region <400> 2223 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2224 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.242 HC variable region <400> 2224 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Glu Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2225 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.243 LC variable region <400> 2225 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2226 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.243 HC variable region <400> 2226 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2227 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC variable region <400> 2227 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2228 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC variable region <400> 2228 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2229 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC variable region <400> 2229 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2230 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC variable region <400> 2230 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2231 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC variable region <400> 2231 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Pro Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2232 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC variable region <400> 2232 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2233 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC variable region <400> 2233 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser 65 70 75 80 Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser 85 90 95 Gly Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 <210> 2234 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC variable region <400> 2234 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2235 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC variable region <400> 2235 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2236 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC variable region <400> 2236 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Thr Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2237 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC variable region <400> 2237 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Gly Ser Ser Asp His 85 90 95 Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 <210> 2238 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC variable region <400> 2238 Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 1 5 10 15 Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 35 40 45 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Lys Leu Ser His Gly Val Val Gly Ala Gln Asp Ala Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 2239 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC variable region <400> 2239 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2240 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC variable region <400> 2240 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2241 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC variable region <400> 2241 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2242 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC variable region <400> 2242 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2243 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC variable region <400> 2243 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2244 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC variable region <400> 2244 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2245 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC variable region <400> 2245 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2246 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC variable region <400> 2246 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2247 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC variable region <400> 2247 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 85 90 95 Pro Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 <210> 2248 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC variable region <400> 2248 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2249 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC variable region <400> 2249 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asn His Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 100 105 110 <210> 2250 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC variable region <400> 2250 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2251 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC variable region <400> 2251 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2252 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC variable region <400> 2252 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2253 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC variable region <400> 2253 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2254 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC variable region <400> 2254 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2255 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC variable region <400> 2255 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2256 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC variable region <400> 2256 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2257 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC variable region <400> 2257 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2258 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC variable region <400> 2258 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2259 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC variable region <400> 2259 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Leu Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2260 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC variable region <400> 2260 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Ile Val Ser Ser 115 120 <210> 2261 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC variable region <400> 2261 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2262 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.261 HC variable region <400> 2262 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2263 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC variable region <400> 2263 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 85 90 95 Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2264 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC variable region <400> 2264 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2265 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC variable region <400> 2265 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Pro Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2266 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC variable region <400> 2266 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2267 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC variable region <400> 2267 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2268 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC variable region <400> 2268 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2269 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC variable region <400> 2269 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2270 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC variable region <400> 2270 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2271 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC variable region <400> 2271 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Arg Asp Ser Ser Ser Asp His 85 90 95 Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 2272 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC variable region <400> 2272 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2273 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC variable region <400> 2273 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2274 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC variable region <400> 2274 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2275 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC variable region <400> 2275 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Asp Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Asn Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Gln Ser Ser Asp Ser Gly 85 90 95 Leu Thr Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2276 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC variable region <400> 2276 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2277 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC variable region <400> 2277 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ala Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2278 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC variable region <400> 2278 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2279 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC variable region <400> 2279 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2280 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC variable region <400> 2280 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2281 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC variable region <400> 2281 Glu Leu Glu Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Asn 85 90 95 Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> 2282 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC variable region <400> 2282 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2283 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC variable region <400> 2283 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2284 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC variable region <400> 2284 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2285 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC variable region <400> 2285 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2286 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC variable region <400> 2286 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2287 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC variable region <400> 2287 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2288 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC variable region <400> 2288 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2289 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC variable region <400> 2289 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Asn Thr Val 20 25 30 Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 35 40 45 Ser Asn Asn Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 50 55 60 Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly 85 90 95 Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 2290 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC variable region <400> 2290 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2291 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC variable region <400> 2291 Glu Leu Glu Leu Thr Gln Pro Ser Ala Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Ser 20 25 30 Asp Val Gly Trp Tyr Gln His Leu Pro Gly Met Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Lys Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu 85 90 95 Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 2292 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC variable region <400> 2292 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2293 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC variable region <400> 2293 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2294 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC variable region <400> 2294 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2295 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC variable region <400> 2295 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Gly Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Phe Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2296 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC variable region <400> 2296 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2297 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC variable region <400> 2297 Glu Leu Thr Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Pro 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 2298 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC variable region <400> 2298 Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2299 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC variable region <400> 2299 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Thr Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Asn Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2300 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC variable region <400> 2300 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Ile Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2301 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.281 LC variable region <400> 2301 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2302 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.281 HC variable region <400> 2302 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Ile Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2303 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC variable region <400> 2303 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Asn Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2304 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC variable region <400> 2304 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Ile Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2305 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC variable region <400> 2305 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Pro 85 90 95 Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2306 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC variable region <400> 2306 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 2307 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC variable region <400> 2307 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2308 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC variable region <400> 2308 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg His Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly His Val Asp Ile Pro Tyr Gly Met Asp Val Trp Gly Gln Gly 100 105 110 Thr Thr Val Thr Val Ser Ser 115 <210> 2309 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC variable region <400> 2309 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2310 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC variable region <400> 2310 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp 100 105 110 Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2311 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC variable region <400> 2311 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2312 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC variable region <400> 2312 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp 100 105 110 Pro Trp Gly Gln Gly Thr Leu Val Thr Val Pro Ser 115 120 <210> 2313 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC variable region <400> 2313 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2314 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC variable region <400> 2314 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2315 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC variable region <400> 2315 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2316 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC variable region <400> 2316 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Asn Leu Gly Tyr Cys Thr Asn Gly Val Cys Ala Pro Ser 100 105 110 Gly Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2317 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC variable region <400> 2317 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2318 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC variable region <400> 2318 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asn Leu Arg Tyr Phe Asp Trp Leu Leu Gly Asp Asp Ala Phe 100 105 110 Asp Ile Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 2319 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC variable region <400> 2319 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2320 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC variable region <400> 2320 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2321 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 291 LC CDR1 <400> 2321 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2322 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 291 LC CDR2 <400> 2322 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2323 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 291 LC CDR3 <400> 2323 Ala Ser Trp Asp Asp Arg Leu Ser Ala Leu Val 1 5 10 <210> 2324 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 291 HC CDR1 <400> 2324 Gly Tyr Tyr Trp Ser 1 5 <210> 2325 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 291 HC CDR2 <400> 2325 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2326 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 291 HC CDR3 <400> 2326 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2327 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 292 LC CDR1 <400> 2327 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2328 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 292 LC CDR2 <400> 2328 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2329 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 292 LC CDR3 <400> 2329 Gly Thr Trp Asp Ser Ser Leu Ser Gly Trp Val 1 5 10 <210> 2330 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 292 HC CDR1 <400> 2330 Ser Tyr Tyr Met His 1 5 <210> 2331 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 292 HC CDR2 <400> 2331 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2332 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 292 HC CDR3 <400> 2332 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2333 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 293 LC CDR1 <400> 2333 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2334 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 293 LC CDR2 <400> 2334 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2335 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 293 LC CDR3 <400> 2335 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 2336 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 293 HC CDR1 <400> 2336 Ser Tyr Ala Met Ser 1 5 <210> 2337 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 293 HC CDR2 <400> 2337 Ala Ile Ser Gly Ser Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2338 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 293 HC CDR3 <400> 2338 Val Arg Tyr Tyr Asp Phe Trp Ser Gly Trp Asp Val Met Asp Val 1 5 10 15 <210> 2339 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 294 LC CDR1 <400> 2339 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2340 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 294 LC CDR2 <400> 2340 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2341 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 294 LC CDR3 <400> 2341 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2342 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 294 HC CDR1 <400> 2342 Ser Tyr Tyr Met His 1 5 <210> 2343 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 294 HC CDR2 <400> 2343 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2344 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 294 HC CDR3 <400> 2344 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2345 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 295 LC CDR1 <400> 2345 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2346 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 295 LC CDR2 <400> 2346 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2347 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 295 LC CDR3 <400> 2347 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 2348 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 295 HC CDR1 <400> 2348 Arg Tyr Ala Met Ser 1 5 <210> 2349 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 295 HC CDR2 <400> 2349 Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2350 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 295 HC CDR3 <400> 2350 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 2351 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 296 LC CDR1 <400> 2351 Thr Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2352 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 296 LC CDR2 <400> 2352 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2353 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 296 LC CDR3 <400> 2353 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2354 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 296 HC CDR1 <400> 2354 Ser Tyr Tyr Met His 1 5 <210> 2355 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 296 HC CDR2 <400> 2355 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2356 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 296 HC CDR3 <400> 2356 Gly Gly Arg His Ser Leu Asp Ala 1 5 <210> 2357 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 297 LC CDR1 <400> 2357 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2358 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 297 LC CDR2 <400> 2358 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2359 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 297 LC CDR3 <400> 2359 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2360 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 297 HC CDR1 <400> 2360 Arg Lys Val Ile Ala 1 5 <210> 2361 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 297 HC CDR2 <400> 2361 Gly His Ala Pro Phe Val Arg Lys Pro Thr Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2362 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 297 HC CDR3 <400> 2362 Lys Ala Val Thr Thr Tyr Ser Gly Phe Asp Asn 1 5 10 <210> 2363 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 298 LC CDR1 <400> 2363 Arg Ala Ser Gln Gly Ile Ser Asn Ser Leu Ala 1 5 10 <210> 2364 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 298 LC CDR2 <400> 2364 Ala Ala Ser Arg Leu Glu Ser 1 5 <210> 2365 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 298 LC CDR3 <400> 2365 Gln Gln Tyr Tyr Ser Thr Pro Tyr Thr 1 5 <210> 2366 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 298 HC CDR1 <400> 2366 Asn Ala Trp Met Thr 1 5 <210> 2367 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 298 HC CDR2 <400> 2367 Arg Ile Lys Thr Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro 1 5 10 15 Val Lys Gly <210> 2368 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> No. 298 HC CDR3 <400> 2368 His Ser Arg Pro Asp Tyr 1 5 <210> 2369 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 299 LC CDR1 <400> 2369 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2370 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 299 LC CDR2 <400> 2370 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2371 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 299 LC CDR3 <400> 2371 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2372 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 299 HC CDR1 <400> 2372 Arg Lys Val Ile Ala 1 5 <210> 2373 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 299 HC CDR2 <400> 2373 Gly His Ala Pro Phe Val Arg Lys Pro Thr Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2374 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 299 HC CDR3 <400> 2374 Lys Ala Val Thr Thr Tyr Ser Gly Phe Asp Thr 1 5 10 <210> 2375 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 300 LC CDR1 <400> 2375 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 2376 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 300 LC CDR2 <400> 2376 Trp Ala Ser Thr Arg Glu Ser 1 5 <210> 2377 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 300 LC CDR3 <400> 2377 Leu Gln Tyr Phe Thr Ile Pro Trp Thr 1 5 <210> 2378 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 300 HC CDR1 <400> 2378 Asn Ala Trp Met Ser 1 5 <210> 2379 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 300 HC CDR2 <400> 2379 Arg Ile Lys Thr Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro 1 5 10 15 Val Lys Gly <210> 2380 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> No. 300 HC CDR3 <400> 2380 Phe Ser Thr Pro Asp Tyr 1 5 <210> 2381 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 301 LC CDR1 <400> 2381 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2382 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 301 LC CDR2 <400> 2382 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 2383 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 301 LC CDR3 <400> 2383 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val 1 5 10 <210> 2384 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 301 HC CDR1 <400> 2384 Arg Tyr Ala Ile Ser 1 5 <210> 2385 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 301 HC CDR2 <400> 2385 Gly Ile Ile Pro Ile Phe Gly Lys Val Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 2386 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 301 HC CDR3 <400> 2386 Gly Gly Ser Thr Trp Tyr Gly Gly Asn Trp Phe Asp Pro 1 5 10 <210> 2387 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 302 LC CDR1 <400> 2387 Ser Gly Asp Val Leu Ala Lys Lys Tyr Ala Arg 1 5 10 <210> 2388 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 302 LC CDR2 <400> 2388 Lys Asp Ser Glu Arg Pro Ser 1 5 <210> 2389 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 302 LC CDR3 <400> 2389 Tyr Ser Ala Ala Asp Asn Asn Gly Val 1 5 <210> 2390 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 302 HC CDR1 <400> 2390 Ser Asp Ala Met His 1 5 <210> 2391 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 302 HC CDR2 <400> 2391 Val Ile Ser Tyr Asp Gly Ser Asn Glu Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2392 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 302 HC CDR3 <400> 2392 Glu Ala Thr Tyr Asp Ser Ser Gly Arg Pro Thr Gly Asp Tyr Gly Met 1 5 10 15 Asp Val <210> 2393 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 303 LC CDR1 <400> 2393 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2394 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 303 LC CDR2 <400> 2394 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2395 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 303 LC CDR3 <400> 2395 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 2396 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 303 HC CDR1 <400> 2396 Gly Tyr Tyr Trp Ser 1 5 <210> 2397 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 303 HC CDR2 <400> 2397 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2398 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 303 HC CDR3 <400> 2398 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2399 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 304 LC CDR1 <400> 2399 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2400 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 304 LC CDR2 <400> 2400 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 2401 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 304 LC CDR3 <400> 2401 Ser Ser Tyr Thr Ser Ser Ser Thr Ser His Val Val 1 5 10 <210> 2402 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 304 HC CDR1 <400> 2402 Ser Tyr Ala Met Asn 1 5 <210> 2403 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 304 HC CDR2 <400> 2403 Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2404 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 304 HC CDR3 <400> 2404 Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser Glu Tyr 1 5 10 15 Tyr Phe Asp Tyr 20 <210> 2405 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 305 LC CDR1 <400> 2405 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2406 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 305 LC CDR2 <400> 2406 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 2407 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 305 LC CDR3 <400> 2407 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val 1 5 10 <210> 2408 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> No. 305 HC CDR1 <400> 2408 Arg Gly Asp Tyr Trp Gly 1 5 <210> 2409 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 305 HC CDR2 <400> 2409 Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2410 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 305 HC CDR3 <400> 2410 His Gly Thr Ser Gly Tyr Tyr Tyr Pro Asn Trp Phe Asp Pro 1 5 10 <210> 2411 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 306 LC CDR1 <400> 2411 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2412 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 306 LC CDR2 <400> 2412 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2413 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 306 LC CDR3 <400> 2413 Ala Ala Trp Asp Asp Ser Leu Asn Ala Ser Leu 1 5 10 <210> 2414 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 306 HC CDR1 <400> 2414 Gly Tyr Tyr Trp Ser 1 5 <210> 2415 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 306 HC CDR2 <400> 2415 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2416 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 306 HC CDR3 <400> 2416 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2417 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 307 LC CDR1 <400> 2417 Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2418 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 307 LC CDR2 <400> 2418 Thr Asp Asn Arg Arg Pro Ser 1 5 <210> 2419 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 307 LC CDR3 <400> 2419 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 2420 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 307 HC CDR1 <400> 2420 Gly Tyr Tyr Trp Ser 1 5 <210> 2421 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 307 HC CDR2 <400> 2421 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2422 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 307 HC CDR3 <400> 2422 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2423 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 308 LC CDR1 <400> 2423 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2424 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 308 LC CDR2 <400> 2424 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2425 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 308 LC CDR3 <400> 2425 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 2426 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 308 HC CDR1 <400> 2426 Gly Tyr Tyr Trp Ser 1 5 <210> 2427 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 308 HC CDR2 <400> 2427 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2428 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 308 HC CDR3 <400> 2428 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2429 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 309 LC CDR1 <400> 2429 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2430 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 309 LC CDR2 <400> 2430 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2431 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 309 LC CDR3 <400> 2431 Ala Ala Arg Asp Asp Ser Leu Asn Gly Ala Val 1 5 10 <210> 2432 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 309 HC CDR1 <400> 2432 Gly Tyr Tyr Trp Ser 1 5 <210> 2433 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 309 HC CDR2 <400> 2433 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2434 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 309 HC CDR3 <400> 2434 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2435 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 310 LC CDR1 <400> 2435 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2436 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 310 LC CDR2 <400> 2436 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2437 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 310 LC CDR3 <400> 2437 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Pro 1 5 10 <210> 2438 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 310 HC CDR1 <400> 2438 Thr Ser Gly Val Gly Val Gly 1 5 <210> 2439 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 310 HC CDR2 <400> 2439 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 2440 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 310 HC CDR3 <400> 2440 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 2441 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 311 LC CDR1 <400> 2441 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2442 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 311 LC CDR2 <400> 2442 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2443 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 311 LC CDR3 <400> 2443 Gln Glu Tyr Gly Ser Ser Pro Arg Arg Val Thr 1 5 10 <210> 2444 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 311 HC CDR1 <400> 2444 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2445 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 311 HC CDR2 <400> 2445 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2446 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 311 HC CDR3 <400> 2446 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2447 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 312 LC CDR1 <400> 2447 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2448 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 312 LC CDR2 <400> 2448 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 2449 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 312 LC CDR3 <400> 2449 Gln Gln Tyr Tyr Gln Val Pro Leu Thr 1 5 <210> 2450 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 312 HC CDR1 <400> 2450 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2451 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 312 HC CDR2 <400> 2451 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2452 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 312 HC CDR3 <400> 2452 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2453 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 313 LC CDR1 <400> 2453 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2454 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 313 LC CDR2 <400> 2454 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2455 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 313 LC CDR3 <400> 2455 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 2456 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 313 HC CDR1 <400> 2456 Asp Tyr Gly Met His 1 5 <210> 2457 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 313 HC CDR2 <400> 2457 Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2458 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 313 HC CDR3 <400> 2458 Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr Tyr Ala 1 5 10 15 Met Asp Val <210> 2459 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 314 LC CDR1 <400> 2459 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2460 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 314 LC CDR2 <400> 2460 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 2461 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 314 LC CDR3 <400> 2461 Ser Ser Tyr Thr Ser Ser Ser Thr Tyr Val 1 5 10 <210> 2462 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 314 HC CDR1 <400> 2462 Glu Leu Ser Ile His 1 5 <210> 2463 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 314 HC CDR2 <400> 2463 Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2464 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 314 HC CDR3 <400> 2464 Ser Pro Ala Val Thr Thr Ala Gly Trp Phe Asp Pro 1 5 10 <210> 2465 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 315 LC CDR1 <400> 2465 Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn Thr Val Asn 1 5 10 <210> 2466 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 315 LC CDR2 <400> 2466 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2467 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 315 LC CDR3 <400> 2467 Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Leu 1 5 10 <210> 2468 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 315 HC CDR1 <400> 2468 Gly Tyr Tyr Trp Ser 1 5 <210> 2469 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 315 HC CDR2 <400> 2469 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2470 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 315 HC CDR3 <400> 2470 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2471 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 316 LC CDR1 <400> 2471 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2472 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 316 LC CDR2 <400> 2472 Asp Val Gly Lys Arg Pro Ser 1 5 <210> 2473 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 316 LC CDR3 <400> 2473 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 2474 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 316 HC CDR1 <400> 2474 Phe Tyr Ala Ile Ser 1 5 <210> 2475 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 316 HC CDR2 <400> 2475 Gly Ile Ile Pro Leu Phe Gly Thr Ala Lys Tyr Ala Gln Arg Phe Gln 1 5 10 15 Asp <210> 2476 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 316 HC CDR3 <400> 2476 Gly Gly Trp Ile Tyr Arg Gly Asn Trp Phe Asp Pro 1 5 10 <210> 2477 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 317 LC CDR1 <400> 2477 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2478 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 317 LC CDR2 <400> 2478 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2479 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 317 LC CDR3 <400> 2479 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Val 1 5 10 <210> 2480 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 317 HC CDR1 <400> 2480 Asn Tyr Gly Ile Ser 1 5 <210> 2481 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 317 HC CDR2 <400> 2481 Gly Ile Ser Ser His Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu Gln 1 5 10 15 Gly <210> 2482 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 317 HC CDR3 <400> 2482 Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Arg Phe 1 5 10 15 Ala Phe Asp Ile 20 <210> 2483 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 318 LC CDR1 <400> 2483 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2484 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 318 LC CDR2 <400> 2484 Glu Val Ser Lys Arg Pro Ser 1 5 <210> 2485 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 318 LC CDR3 <400> 2485 Ser Ser Tyr Ala Gly Ser Asn Tyr Val Val 1 5 10 <210> 2486 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 318 HC CDR1 <400> 2486 Ser Tyr Ala Met Ser 1 5 <210> 2487 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 318 HC CDR2 <400> 2487 Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2488 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 318 HC CDR3 <400> 2488 Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser Glu Tyr 1 5 10 15 Tyr Phe Asp Tyr 20 <210> 2489 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 319 LC CDR1 <400> 2489 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2490 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 319 LC CDR2 <400> 2490 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 2491 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 319 LC CDR3 <400> 2491 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Gly Val 1 5 10 <210> 2492 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 319 HC CDR1 <400> 2492 Ser Tyr Ala Met Ser 1 5 <210> 2493 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 319 HC CDR2 <400> 2493 Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2494 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 319 HC CDR3 <400> 2494 Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser Glu Tyr 1 5 10 15 Tyr Phe Asp Tyr 20 <210> 2495 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 320 LC CDR1 <400> 2495 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2496 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 320 LC CDR2 <400> 2496 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2497 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 320 LC CDR3 <400> 2497 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2498 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 320 HC CDR1 <400> 2498 Gly Tyr Tyr Met His 1 5 <210> 2499 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 320 HC CDR2 <400> 2499 Val Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2500 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 320 HC CDR3 <400> 2500 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2501 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 321 LC CDR1 <400> 2501 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2502 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 321 LC CDR2 <400> 2502 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2503 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 321 LC CDR3 <400> 2503 Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val 1 5 10 <210> 2504 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 321 HC CDR1 <400> 2504 Ser Tyr Trp Ile Val 1 5 <210> 2505 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 321 HC CDR2 <400> 2505 Thr Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 2506 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 321 HC CDR3 <400> 2506 Gly Pro Asn Ile Tyr Asn Trp Phe Asp Ser 1 5 10 <210> 2507 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 322 LC CDR1 <400> 2507 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2508 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 322 LC CDR2 <400> 2508 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 2509 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 322 LC CDR3 <400> 2509 Gln Gln Ser Tyr Ser Thr Pro Leu Thr 1 5 <210> 2510 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 322 HC CDR1 <400> 2510 Ser Asn Tyr Met Thr 1 5 <210> 2511 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 322 HC CDR2 <400> 2511 Ile Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 2512 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 322 HC CDR3 <400> 2512 Asp Leu Pro Leu Thr Gly Thr Thr Leu Asp Tyr 1 5 10 <210> 2513 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 323 LC CDR1 <400> 2513 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 2514 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 323 LC CDR2 <400> 2514 Asp Asp Ser Asp Arg Pro Ser 1 5 <210> 2515 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 323 LC CDR3 <400> 2515 Gln Val Trp Asp Ser Ser Ser Asp His Val Val 1 5 10 <210> 2516 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 323 HC CDR1 <400> 2516 Asp Tyr Gly Met His 1 5 <210> 2517 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 323 HC CDR2 <400> 2517 Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2518 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 323 HC CDR3 <400> 2518 Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr Tyr Ala 1 5 10 15 Met Asp Val <210> 2519 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 324 LC CDR1 <400> 2519 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2520 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 324 LC CDR2 <400> 2520 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2521 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 324 LC CDR3 <400> 2521 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Val 1 5 10 <210> 2522 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 324 HC CDR1 <400> 2522 Asn Tyr Pro Leu Thr 1 5 <210> 2523 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 324 HC CDR2 <400> 2523 Gly Ile Ile Pro Ile Ile Gly Ala Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2524 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 324 HC CDR3 <400> 2524 Gly Arg Gly Tyr Ser Gly Tyr Gly Ala Ala Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 2525 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 325 LC CDR1 <400> 2525 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2526 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 325 LC CDR2 <400> 2526 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2527 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 325 LC CDR3 <400> 2527 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Trp Val 1 5 10 <210> 2528 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 325 HC CDR1 <400> 2528 Arg Tyr Ala Ile Ser 1 5 <210> 2529 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 325 HC CDR2 <400> 2529 Gly Ile Ile Pro Ile Phe Gly Thr Gly Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2530 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 325 HC CDR3 <400> 2530 Ser Leu Tyr Tyr Tyr Asp Arg Ser Gly Tyr Pro Ile Ser Glu Asp Tyr 1 5 10 15 Phe Asp Tyr <210> 2531 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 326 LC CDR1 <400> 2531 Arg Ala Ser Gln Ser Val Gly Ser Ser Tyr Leu Ala 1 5 10 <210> 2532 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 326 LC CDR2 <400> 2532 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 2533 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 326 LC CDR3 <400> 2533 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 2534 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 326 HC CDR1 <400> 2534 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2535 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 326 HC CDR2 <400> 2535 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2536 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 326 HC CDR3 <400> 2536 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2537 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 327 LC CDR1 <400> 2537 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2538 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 327 LC CDR2 <400> 2538 Thr Asn Asn Arg Arg Pro Ser 1 5 <210> 2539 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 327 LC CDR3 <400> 2539 Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val 1 5 10 <210> 2540 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 327 HC CDR1 <400> 2540 Ser His Trp Ile Ala 1 5 <210> 2541 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 327 HC CDR2 <400> 2541 Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 2542 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 327 HC CDR3 <400> 2542 Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser 1 5 10 <210> 2543 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 328 LC CDR1 <400> 2543 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 2544 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 328 LC CDR2 <400> 2544 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 2545 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 328 LC CDR3 <400> 2545 Gln Val Trp Asp Ser Ser Ser Asp His Trp Val 1 5 10 <210> 2546 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 328 HC CDR1 <400> 2546 Asp Tyr Ala Met Ser 1 5 <210> 2547 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 328 HC CDR2 <400> 2547 Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Asn Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2548 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 328 HC CDR3 <400> 2548 Val Tyr Cys Gly Asp Asp Cys Tyr Pro Val Val Gly Thr Pro Gly Asp 1 5 10 15 Ala Phe Asp Ile 20 <210> 2549 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 329 LC CDR1 <400> 2549 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2550 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 329 LC CDR2 <400> 2550 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2551 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 329 LC CDR3 <400> 2551 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Trp Val 1 5 10 <210> 2552 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 329 HC CDR1 <400> 2552 Asp Tyr Gly Met His 1 5 <210> 2553 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 329 HC CDR2 <400> 2553 Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2554 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 329 HC CDR3 <400> 2554 Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr Tyr Ala 1 5 10 15 Met Asp Val <210> 2555 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 330 LC CDR1 <400> 2555 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2556 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 330 LC CDR2 <400> 2556 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2557 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 330 LC CDR3 <400> 2557 Gln Gln Tyr Gly Ser Ser Pro Gln Thr 1 5 <210> 2558 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 330 HC CDR1 <400> 2558 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2559 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 330 HC CDR2 <400> 2559 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2560 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 330 HC CDR3 <400> 2560 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2561 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 331 LC CDR1 <400> 2561 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2562 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 331 LC CDR2 <400> 2562 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2563 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 331 LC CDR3 <400> 2563 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 2564 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 331 HC CDR1 <400> 2564 Gly Tyr Tyr Trp Ser 1 5 <210> 2565 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 331 HC CDR2 <400> 2565 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2566 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 331 HC CDR3 <400> 2566 Gly Arg Tyr Tyr Ser Ser Trp Tyr Gly Pro Arg Thr Trp Phe Asp Pro 1 5 10 15 <210> 2567 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 332 LC CDR1 <400> 2567 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 2568 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 332 LC CDR2 <400> 2568 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 2569 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 332 LC CDR3 <400> 2569 Gln Ser Tyr Asp Ser Ser Asn Trp Val 1 5 <210> 2570 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 332 HC CDR1 <400> 2570 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2571 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 332 HC CDR2 <400> 2571 Asn Phe Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2572 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 332 HC CDR3 <400> 2572 Gln Glu Trp Leu Arg Gly Gly Phe Asp Asp 1 5 10 <210> 2573 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 333 LC CDR1 <400> 2573 Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn Tyr Val His 1 5 10 <210> 2574 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 333 LC CDR2 <400> 2574 Ser Asn Asp Gln Arg Pro Ser 1 5 <210> 2575 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 333 LC CDR3 <400> 2575 Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 1 5 10 <210> 2576 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 333 HC CDR1 <400> 2576 Ser Tyr Ala Ile Ser 1 5 <210> 2577 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 333 HC CDR2 <400> 2577 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Arg Phe Gln 1 5 10 15 Gly <210> 2578 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 333 HC CDR3 <400> 2578 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 2579 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 334 LC CDR1 <400> 2579 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2580 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 334 LC CDR2 <400> 2580 Asp Ala Ser Ser Arg Ala Thr 1 5 <210> 2581 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 334 LC CDR3 <400> 2581 Gln Gln Tyr Gly Ser Ser Pro Ser Ile Thr 1 5 10 <210> 2582 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 334 HC CDR1 <400> 2582 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2583 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 334 HC CDR2 <400> 2583 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2584 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 334 HC CDR3 <400> 2584 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2585 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 335 LC CDR1 <400> 2585 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2586 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 335 LC CDR2 <400> 2586 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2587 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 335 LC CDR3 <400> 2587 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Pro Val 1 5 10 <210> 2588 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 335 HC CDR1 <400> 2588 Ser Tyr Asp Ile Ser 1 5 <210> 2589 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 335 HC CDR2 <400> 2589 Gly Ile Ile Pro Ile Leu Gly Ile Pro Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2590 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 335 HC CDR3 <400> 2590 Ser Arg Gly Tyr Ser Gly Tyr Gly Ala Asn Trp Tyr Phe Asp Leu 1 5 10 15 <210> 2591 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 336 LC CDR1 <400> 2591 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 2592 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 336 LC CDR2 <400> 2592 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 2593 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 336 LC CDR3 <400> 2593 Gln Ser Tyr Asp Ser Ser Asn Trp Val 1 5 <210> 2594 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 336 HC CDR1 <400> 2594 Arg Tyr Gly Ile Ser 1 5 <210> 2595 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 336 HC CDR2 <400> 2595 Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu Gln 1 5 10 15 Gly <210> 2596 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 336 HC CDR3 <400> 2596 Val Leu Gly Ile Ala Val Ala Gly Thr Pro Ile 1 5 10 <210> 2597 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 337 LC CDR1 <400> 2597 Arg Ala Ser Gln Ser Val Arg Ser Asp Ile Ala 1 5 10 <210> 2598 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 337 LC CDR2 <400> 2598 Asp Thr Ser Thr Arg Ala Thr 1 5 <210> 2599 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 337 LC CDR3 <400> 2599 Gln Gln Tyr Tyr Thr Thr Pro Phe Thr 1 5 <210> 2600 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 337 HC CDR1 <400> 2600 Asp Tyr Tyr Ile Gln 1 5 <210> 2601 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 337 HC CDR2 <400> 2601 Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe Gln 1 5 10 15 Gly <210> 2602 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 337 HC CDR3 <400> 2602 Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro 1 5 10 <210> 2603 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 338 LC CDR1 <400> 2603 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2604 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 338 LC CDR2 <400> 2604 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2605 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 338 LC CDR3 <400> 2605 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Leu Trp Val 1 5 10 <210> 2606 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 338 HC CDR1 <400> 2606 Ser Asn Tyr Met Ser 1 5 <210> 2607 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 338 HC CDR2 <400> 2607 Val Ile Tyr Pro Gly Gly Ser Thr Phe Phe Ala Asp Ser Val Gln Gly 1 5 10 15 <210> 2608 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 338 HC CDR3 <400> 2608 Ser Tyr Asp Phe Leu Thr Asp Tyr Thr Asp Ala Phe Asp Ile 1 5 10 <210> 2609 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 339 LC CDR1 <400> 2609 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2610 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 339 LC CDR2 <400> 2610 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 2611 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 339 LC CDR3 <400> 2611 Ser Ser Tyr Thr Ser Ser Ser Pro Trp Val 1 5 10 <210> 2612 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 339 HC CDR1 <400> 2612 Ser Tyr Ala Met Ser 1 5 <210> 2613 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 339 HC CDR2 <400> 2613 Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2614 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 339 HC CDR3 <400> 2614 Gly Val Val Thr Ala Asp Trp Tyr Phe Asp Leu 1 5 10 <210> 2615 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 340 LC CDR1 <400> 2615 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2616 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 340 LC CDR2 <400> 2616 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2617 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 340 LC CDR3 <400> 2617 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Pro Trp Val 1 5 10 <210> 2618 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 340 HC CDR1 <400> 2618 Arg Tyr Ala Ile Asn 1 5 <210> 2619 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 340 HC CDR2 <400> 2619 Gly Ile Ile Pro Leu Leu Gly Thr Ala Asp Tyr Pro Gln Lys Phe Gln 1 5 10 15 Gly <210> 2620 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 340 HC CDR3 <400> 2620 Thr Leu Tyr Tyr Tyr Asp Arg Ser Gly Asn Ala Arg Thr Asp Asp Tyr 1 5 10 15 Phe Asp His <210> 2621 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 341 LC CDR1 <400> 2621 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2622 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 341 LC CDR2 <400> 2622 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2623 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 341 LC CDR3 <400> 2623 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 2624 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 341 HC CDR1 <400> 2624 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2625 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 341 HC CDR2 <400> 2625 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2626 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 341 HC CDR3 <400> 2626 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2627 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 342 LC CDR1 <400> 2627 Arg Ala Ser Gln Ser Val Asn Ser Asn Leu Ala 1 5 10 <210> 2628 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 342 LC CDR2 <400> 2628 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 2629 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 342 LC CDR3 <400> 2629 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 2630 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 342 HC CDR1 <400> 2630 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2631 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 342 HC CDR2 <400> 2631 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2632 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 342 HC CDR3 <400> 2632 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2633 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 343 LC CDR1 <400> 2633 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2634 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 343 LC CDR2 <400> 2634 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 2635 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 343 LC CDR3 <400> 2635 Gln Gln Ser Tyr Ser Thr Pro Leu Thr 1 5 <210> 2636 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 343 HC CDR1 <400> 2636 Ser Asn Tyr Met Ser 1 5 <210> 2637 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 343 HC CDR2 <400> 2637 Val Ile Tyr Pro Gly Gly Ser Thr Phe Phe Ala Asp Ser Val Gln Gly 1 5 10 15 <210> 2638 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 343 HC CDR3 <400> 2638 Ser Tyr Asp Phe Leu Thr Asp Tyr Thr Asp Ala Phe Asp Ile 1 5 10 <210> 2639 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 344 LC CDR1 <400> 2639 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2640 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 344 LC CDR2 <400> 2640 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2641 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 344 LC CDR3 <400> 2641 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val 1 5 10 <210> 2642 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 344 HC CDR1 <400> 2642 Asp Tyr Ala Met His 1 5 <210> 2643 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 344 HC CDR2 <400> 2643 Gly Ile Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2644 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 344 HC CDR3 <400> 2644 Glu Glu Leu Gly Pro Tyr Ser Asn Arg Trp Tyr Ser Ser Ser Asp Gly 1 5 10 15 Met Asp Val <210> 2645 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 345 LC CDR1 <400> 2645 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2646 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 345 LC CDR2 <400> 2646 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 2647 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 345 LC CDR3 <400> 2647 Gln Gln Ser Tyr Ser Thr Pro Leu Thr 1 5 <210> 2648 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 345 HC CDR1 <400> 2648 Ser Ser Ala Ile Asn 1 5 <210> 2649 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 345 HC CDR2 <400> 2649 Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2650 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 345 HC CDR3 <400> 2650 Asp His Ile Val Ser Pro Leu Tyr Gly Met Asp Val 1 5 10 <210> 2651 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 346 LC CDR1 <400> 2651 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2652 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 346 LC CDR2 <400> 2652 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2653 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 346 LC CDR3 <400> 2653 Gln Ser Tyr Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2654 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 346 HC CDR1 <400> 2654 Ser Asn Tyr Met Ser 1 5 <210> 2655 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 346 HC CDR2 <400> 2655 Val Ile Tyr Pro Gly Gly Ser Thr Phe Phe Ala Asp Ser Val Gln Gly 1 5 10 15 <210> 2656 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 346 HC CDR3 <400> 2656 Ser Tyr Asp Phe Leu Thr Asp Tyr Thr Asp Ala Phe Asp Ile 1 5 10 <210> 2657 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 347 LC CDR1 <400> 2657 Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 1 5 10 <210> 2658 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 347 LC CDR2 <400> 2658 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 2659 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 347 LC CDR3 <400> 2659 Gln Gln Tyr Tyr Ser Thr Pro Ile Thr 1 5 <210> 2660 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 347 HC CDR1 <400> 2660 Asp Tyr Tyr Ile Gln 1 5 <210> 2661 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 347 HC CDR2 <400> 2661 Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe Gln 1 5 10 15 Gly <210> 2662 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 347 HC CDR3 <400> 2662 Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro 1 5 10 <210> 2663 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 348 LC CDR1 <400> 2663 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Ser His Val Ser 1 5 10 <210> 2664 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 348 LC CDR2 <400> 2664 Glu Val Ser Asp Arg Pro Ser 1 5 <210> 2665 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 348 LC CDR3 <400> 2665 Asn Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 2666 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 348 HC CDR1 <400> 2666 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2667 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 348 HC CDR2 <400> 2667 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2668 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 348 HC CDR3 <400> 2668 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2669 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 349 LC CDR1 <400> 2669 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 2670 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 349 LC CDR2 <400> 2670 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 2671 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 349 LC CDR3 <400> 2671 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 2672 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 349 HC CDR1 <400> 2672 Gly Ser Ser Tyr Tyr Trp Gly 1 5 <210> 2673 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 349 HC CDR2 <400> 2673 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2674 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 349 HC CDR3 <400> 2674 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 2675 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 350 LC CDR1 <400> 2675 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2676 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 350 LC CDR2 <400> 2676 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2677 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 350 LC CDR3 <400> 2677 Gln Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 1 5 10 <210> 2678 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 350 HC CDR1 <400> 2678 Ser Tyr Ala Ile Ile 1 5 <210> 2679 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 350 HC CDR2 <400> 2679 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2680 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 350 HC CDR3 <400> 2680 Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr 1 5 10 <210> 2681 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 351 LC CDR1 <400> 2681 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp 1 5 10 <210> 2682 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 351 LC CDR2 <400> 2682 Asp Asp Ser Asp Arg Pro Ser 1 5 <210> 2683 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 351 LC CDR3 <400> 2683 Gln Val Trp Asp Ser Ser Ser Asp Arg Val Val 1 5 10 <210> 2684 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 351 HC CDR1 <400> 2684 Asp Tyr Ala Met His 1 5 <210> 2685 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 351 HC CDR2 <400> 2685 Gly Thr Thr Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2686 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 351 HC CDR3 <400> 2686 Asp Ile Gly Ser Gly Asp Arg Pro Asp Ala Phe His Leu 1 5 10 <210> 2687 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 352 LC CDR1 <400> 2687 Ser Gly Ser Ser Ser Asn Ile Glu Asn Asn Tyr Val Ser 1 5 10 <210> 2688 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 352 LC CDR2 <400> 2688 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2689 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 352 LC CDR3 <400> 2689 Gly Thr Trp Asp Asn Ser Leu Ser Ala Trp Val 1 5 10 <210> 2690 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 352 HC CDR1 <400> 2690 Ser Tyr Tyr Met His 1 5 <210> 2691 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 352 HC CDR2 <400> 2691 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2692 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 352 HC CDR3 <400> 2692 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2693 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 353 LC CDR1 <400> 2693 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 2694 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 353 LC CDR2 <400> 2694 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 2695 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 353 LC CDR3 <400> 2695 Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 1 5 <210> 2696 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 353 HC CDR1 <400> 2696 Ser Ser Pro Met His 1 5 <210> 2697 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 353 HC CDR2 <400> 2697 Val Ile Ser Tyr Gly Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2698 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 353 HC CDR3 <400> 2698 Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2699 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 354 LC CDR1 <400> 2699 Thr Gly Asn Arg Ser Asp Ile Gly Gly Tyr Asn Ser Leu Ser 1 5 10 <210> 2700 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 354 LC CDR2 <400> 2700 Asp Val Asn Asn Arg Pro Ser 1 5 <210> 2701 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 354 LC CDR3 <400> 2701 Asn Ser Tyr Thr Ser Lys Asn Thr Trp Val 1 5 10 <210> 2702 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 354 HC CDR1 <400> 2702 Ser Ser Pro Met His 1 5 <210> 2703 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 354 HC CDR2 <400> 2703 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2704 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 354 HC CDR3 <400> 2704 Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2705 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 355 LC CDR1 <400> 2705 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 2706 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 355 LC CDR2 <400> 2706 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 2707 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 355 LC CDR3 <400> 2707 Gln Gln Tyr Gly Ser Ser Pro Phe Thr 1 5 <210> 2708 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 355 HC CDR1 <400> 2708 Ser Ser Pro Met His 1 5 <210> 2709 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 355 HC CDR2 <400> 2709 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2710 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 355 HC CDR3 <400> 2710 Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2711 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 356 LC CDR1 <400> 2711 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2712 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 356 LC CDR2 <400> 2712 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 2713 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 356 LC CDR3 <400> 2713 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 2714 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 356 HC CDR1 <400> 2714 Ser Ser Pro Met His 1 5 <210> 2715 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 356 HC CDR2 <400> 2715 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2716 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 356 HC CDR3 <400> 2716 Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2717 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 357 LC CDR1 <400> 2717 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 2718 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 357 LC CDR2 <400> 2718 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 2719 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 357 LC CDR3 <400> 2719 Gln Gln Tyr Gly Ser Ser Pro Ala Leu Thr 1 5 10 <210> 2720 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 357 HC CDR1 <400> 2720 Ser Ser Pro Met His 1 5 <210> 2721 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 357 HC CDR2 <400> 2721 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2722 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 357 HC CDR3 <400> 2722 Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2723 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 358 LC CDR1 <400> 2723 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2724 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 358 LC CDR2 <400> 2724 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2725 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 358 LC CDR3 <400> 2725 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2726 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 358 HC CDR1 <400> 2726 Arg Lys Val Ile Ala 1 5 <210> 2727 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 358 HC CDR2 <400> 2727 Gly His Ala Pro Phe Val Arg Lys Pro Thr Tyr Ala Arg Lys Phe Gln 1 5 10 15 Gly <210> 2728 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 358 HC CDR3 <400> 2728 Lys Ala Val Thr Thr Tyr Ser Gly Phe Asp Asn 1 5 10 <210> 2729 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 359 LC CDR1 <400> 2729 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Asn Val Ser 1 5 10 <210> 2730 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 359 LC CDR2 <400> 2730 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 2731 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 359 LC CDR3 <400> 2731 Ser Ser Tyr Thr Ser Ser Ser Pro Trp Val 1 5 10 <210> 2732 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 359 HC CDR1 <400> 2732 Ser Tyr Ala Ile Ser 1 5 <210> 2733 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 359 HC CDR2 <400> 2733 Gly Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2734 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 359 HC CDR3 <400> 2734 Asp Pro Thr Ser Arg Ser Thr Tyr Tyr Tyr Tyr Ser Gly Ser Tyr Tyr 1 5 10 15 Pro <210> 2735 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 360 LC CDR1 <400> 2735 Thr Gly Thr Ser Thr Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2736 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 360 LC CDR2 <400> 2736 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 2737 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 360 LC CDR3 <400> 2737 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val 1 5 10 <210> 2738 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 360 HC CDR1 <400> 2738 Asn Tyr Gly Met His 1 5 <210> 2739 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 360 HC CDR2 <400> 2739 Val Met Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2740 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 360 HC CDR3 <400> 2740 Pro Asp Asp Ser Ser Gly Tyr Tyr Pro Asp Tyr 1 5 10 <210> 2741 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 361 LC CDR1 <400> 2741 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2742 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 361 LC CDR2 <400> 2742 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 2743 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 361 LC CDR3 <400> 2743 Ser Ser Tyr Thr Ser Ser Arg Thr Trp Val 1 5 10 <210> 2744 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 361 HC CDR1 <400> 2744 Gly Tyr Ala Met His 1 5 <210> 2745 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 361 HC CDR2 <400> 2745 Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2746 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 361 HC CDR3 <400> 2746 Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val 1 5 10 <210> 2747 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 362 LC CDR1 <400> 2747 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Ala Val Asn 1 5 10 <210> 2748 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 362 LC CDR2 <400> 2748 Ser Asn Ser Tyr Arg Pro Ser 1 5 <210> 2749 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 362 LC CDR3 <400> 2749 Gln Ser Tyr Asp Ser Ala Leu Arg Gly Pro Leu 1 5 10 <210> 2750 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 362 HC CDR1 <400> 2750 Ser Tyr Gly Ile Ser 1 5 <210> 2751 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 362 HC CDR2 <400> 2751 Gly Ile Ile Pro Ile Leu Ala Thr Thr Lys Phe Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2752 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 362 HC CDR3 <400> 2752 Gly Trp Gly Leu Arg Leu Phe Gly Glu Phe Ser Val Trp Phe Asp Pro 1 5 10 15 <210> 2753 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 363 LC CDR1 <400> 2753 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2754 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 363 LC CDR2 <400> 2754 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2755 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 363 LC CDR3 <400> 2755 Gln Ser Tyr Asp Ser Ser Leu Ser Asp Val Val 1 5 10 <210> 2756 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 363 HC CDR1 <400> 2756 Ser Tyr Gly Ile Ser 1 5 <210> 2757 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 363 HC CDR2 <400> 2757 Gly Ile Ile Pro Ile Leu Ala Thr Thr Lys Phe Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2758 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 363 HC CDR3 <400> 2758 Gly Trp Gly Leu Arg Leu Phe Gly Glu Phe Ser Val Trp Phe Asp Pro 1 5 10 15 <210> 2759 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 364 LC CDR1 <400> 2759 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2760 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 364 LC CDR2 <400> 2760 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 2761 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 364 LC CDR3 <400> 2761 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 2762 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 364 HC CDR1 <400> 2762 Ser Tyr Ala Met His 1 5 <210> 2763 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 364 HC CDR2 <400> 2763 Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2764 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 364 HC CDR3 <400> 2764 Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val 1 5 10 <210> 2765 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 365 LC CDR1 <400> 2765 Ser Ser Ser Thr Gly Ala Val Thr Arg Gly His Phe Pro Asn 1 5 10 <210> 2766 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 365 LC CDR2 <400> 2766 Ser Thr Ser Asn Lys His Ser 1 5 <210> 2767 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 365 LC CDR3 <400> 2767 Leu Leu Tyr Asp Ala Gly Ala Pro Gly Trp Val 1 5 10 <210> 2768 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 365 HC CDR1 <400> 2768 Ser Tyr Pro Met His 1 5 <210> 2769 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 365 HC CDR2 <400> 2769 Val Ile Ser Tyr Asp Gly Ser Leu Lys Tyr Tyr Val Asp Ser Val Lys 1 5 10 15 Gly <210> 2770 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 365 HC CDR3 <400> 2770 Asp Ser Ser Cys Ser Gly Gly Ser Cys Phe Asp Tyr 1 5 10 <210> 2771 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 366 LC CDR1 <400> 2771 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2772 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 366 LC CDR2 <400> 2772 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2773 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 366 LC CDR3 <400> 2773 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val 1 5 10 <210> 2774 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 366 HC CDR1 <400> 2774 Ser Tyr Gly Ile Ser 1 5 <210> 2775 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 366 HC CDR2 <400> 2775 Gly Ile Ile Pro Ile Leu Ala Thr Thr Lys Phe Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2776 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 366 HC CDR3 <400> 2776 Gly Trp Gly Leu Arg Leu Phe Gly Glu Phe Ser Val Trp Phe Asp Pro 1 5 10 15 <210> 2777 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 367 LC CDR1 <400> 2777 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2778 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 367 LC CDR2 <400> 2778 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2779 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 367 LC CDR3 <400> 2779 Gly Ala Trp Asp Ser Ser Leu Ser Thr Pro Asn Trp Val 1 5 10 <210> 2780 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 367 HC CDR1 <400> 2780 Ser Tyr Pro Met His 1 5 <210> 2781 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 367 HC CDR2 <400> 2781 Val Ile Ser Tyr Asp Gly Ser Leu Lys Tyr Tyr Val Asp Ser Val Lys 1 5 10 15 Gly <210> 2782 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 367 HC CDR3 <400> 2782 Asp Ser Ser Cys Ser Gly Gly Ser Cys Phe Asp Tyr 1 5 10 <210> 2783 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 368 LC CDR1 <400> 2783 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2784 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 368 LC CDR2 <400> 2784 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2785 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 368 LC CDR3 <400> 2785 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 2786 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 368 HC CDR1 <400> 2786 Ser Asn Trp Ile Ala 1 5 <210> 2787 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 368 HC CDR2 <400> 2787 Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Asn Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 2788 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 368 HC CDR3 <400> 2788 Leu Ala Tyr Phe His Pro Gln Arg Asn Gly Gly Tyr Glu Tyr Tyr Phe 1 5 10 15 Asp Tyr <210> 2789 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 369 LC CDR1 <400> 2789 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2790 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 369 LC CDR2 <400> 2790 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2791 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 369 LC CDR3 <400> 2791 Gln Ser Tyr Asp Ser Arg Leu Arg Ala Val Val 1 5 10 <210> 2792 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 369 HC CDR1 <400> 2792 Thr Gln Tyr Leu His 1 5 <210> 2793 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 369 HC CDR2 <400> 2793 Ile Ile Asn Pro Tyr Gly Gly Ser Thr Thr Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2794 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 369 HC CDR3 <400> 2794 Ser Pro Ser Gly Tyr Tyr Gly Asp Tyr Glu Gly Asp Ala Phe Asp Ile 1 5 10 15 <210> 2795 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 370 LC CDR1 <400> 2795 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2796 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 370 LC CDR2 <400> 2796 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2797 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 370 LC CDR3 <400> 2797 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 2798 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 370 HC CDR1 <400> 2798 Ser Tyr Val Ile Ser 1 5 <210> 2799 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 370 HC CDR2 <400> 2799 Arg Ile Ile Pro Ile Phe Gly Thr Val Lys Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2800 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 370 HC CDR3 <400> 2800 Asp Leu Pro Gly Asp Ser Arg Asp Gly Tyr Asn Tyr Asp Ala Phe Asp 1 5 10 15 Ile <210> 2801 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 371 LC CDR1 <400> 2801 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2802 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 371 LC CDR2 <400> 2802 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2803 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 371 LC CDR3 <400> 2803 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 2804 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 371 HC CDR1 <400> 2804 Ser Phe Ala Met His 1 5 <210> 2805 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 371 HC CDR2 <400> 2805 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2806 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 371 HC CDR3 <400> 2806 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 2807 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 372 LC CDR1 <400> 2807 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 2808 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 372 LC CDR2 <400> 2808 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 2809 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 372 LC CDR3 <400> 2809 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 2810 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 372 HC CDR1 <400> 2810 Ser Tyr Ala Ile Ser 1 5 <210> 2811 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 372 HC CDR2 <400> 2811 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2812 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 372 HC CDR3 <400> 2812 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 2813 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 373 LC CDR1 <400> 2813 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2814 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 373 LC CDR2 <400> 2814 Asn Asn Asn Gln Arg Pro Ser 1 5 <210> 2815 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 373 LC CDR3 <400> 2815 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 2816 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 373 HC CDR1 <400> 2816 Ser Tyr Trp Ile Gly 1 5 <210> 2817 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 373 HC CDR2 <400> 2817 Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 2818 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 373 HC CDR3 <400> 2818 Gly Pro Asn Ile Tyr Asn Trp Phe Asp Ser 1 5 10 <210> 2819 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 374 LC CDR1 <400> 2819 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2820 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 374 LC CDR2 <400> 2820 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2821 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 374 LC CDR3 <400> 2821 Gln Gln Arg Arg Asn Trp Pro Val Leu Thr 1 5 10 <210> 2822 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 374 HC CDR1 <400> 2822 Ser Tyr Ala Ile Ser 1 5 <210> 2823 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 374 HC CDR2 <400> 2823 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2824 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 374 HC CDR3 <400> 2824 Val Glu Gly Tyr Asp Ser Ser Gly Tyr Tyr Leu Asp Tyr 1 5 10 <210> 2825 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 375 LC CDR1 <400> 2825 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2826 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 375 LC CDR2 <400> 2826 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2827 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 375 LC CDR3 <400> 2827 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 2828 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 375 HC CDR1 <400> 2828 Asp Tyr Gly Met His 1 5 <210> 2829 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 375 HC CDR2 <400> 2829 Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2830 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 375 HC CDR3 <400> 2830 Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr Tyr Ala 1 5 10 15 Met Asp Val <210> 2831 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 376 LC CDR1 <400> 2831 Arg Ala Ser Gln Ser Val Ser Thr Phe Leu Ala 1 5 10 <210> 2832 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 376 LC CDR2 <400> 2832 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2833 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 376 LC CDR3 <400> 2833 Gln Gln Arg Ser Asn Trp Pro Pro Arg Ile Thr 1 5 10 <210> 2834 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 376 HC CDR1 <400> 2834 Ser Tyr Ala Ile Ser 1 5 <210> 2835 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 376 HC CDR2 <400> 2835 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2836 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 376 HC CDR3 <400> 2836 Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr 1 5 10 <210> 2837 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 377 LC CDR1 <400> 2837 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2838 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 377 LC CDR2 <400> 2838 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 2839 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 377 LC CDR3 <400> 2839 Gln Gln Ser Tyr Ser Thr Pro Phe Thr 1 5 <210> 2840 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 377 HC CDR1 <400> 2840 Ser Tyr Ala Met His 1 5 <210> 2841 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 377 HC CDR2 <400> 2841 Val Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2842 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 377 HC CDR3 <400> 2842 Ala Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2843 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 378 LC CDR1 <400> 2843 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2844 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 378 LC CDR2 <400> 2844 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2845 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 378 LC CDR3 <400> 2845 Gln Gln Arg Ser Asn Trp Pro Lys Tyr Thr 1 5 10 <210> 2846 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 378 HC CDR1 <400> 2846 Ser Tyr Ala Ile Ser 1 5 <210> 2847 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 378 HC CDR2 <400> 2847 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2848 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 378 HC CDR3 <400> 2848 Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Glu Tyr 1 5 10 <210> 2849 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 379 LC CDR1 <400> 2849 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2850 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 379 LC CDR2 <400> 2850 Lys Ala Ser Ser Leu Glu Ser 1 5 <210> 2851 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 379 LC CDR3 <400> 2851 Gln Gln Ser Tyr Ser Thr Trp Thr 1 5 <210> 2852 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 379 HC CDR1 <400> 2852 Ser Tyr Ala Met His 1 5 <210> 2853 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 379 HC CDR2 <400> 2853 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2854 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 379 HC CDR3 <400> 2854 Ala Arg Gly Gly Ser Tyr Leu Tyr Gly Met Asp Val 1 5 10 <210> 2855 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 380 LC CDR1 <400> 2855 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2856 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 380 LC CDR2 <400> 2856 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2857 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 380 LC CDR3 <400> 2857 Gln Gln Arg Arg Asn Trp Pro Pro Arg Ile Thr 1 5 10 <210> 2858 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 380 HC CDR1 <400> 2858 Ser Tyr Ala Ile Ser 1 5 <210> 2859 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 380 HC CDR2 <400> 2859 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2860 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 380 HC CDR3 <400> 2860 Val Glu Gly Tyr Asp Ser Ser Gly Tyr Tyr Leu Asp Tyr 1 5 10 <210> 2861 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 381 LC CDR1 <400> 2861 Ser Gly Ser Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser 1 5 10 <210> 2862 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 381 LC CDR2 <400> 2862 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2863 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 381 LC CDR3 <400> 2863 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2864 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 381 HC CDR1 <400> 2864 Ser Tyr Tyr Met His 1 5 <210> 2865 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 381 HC CDR2 <400> 2865 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2866 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 381 HC CDR3 <400> 2866 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2867 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 382 LC CDR1 <400> 2867 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2868 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 382 LC CDR2 <400> 2868 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2869 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 382 LC CDR3 <400> 2869 Ala Ala Trp Asp Asp Ser Leu Gly Gly Pro Val 1 5 10 <210> 2870 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 382 HC CDR1 <400> 2870 Thr Tyr Gly Met His 1 5 <210> 2871 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 382 HC CDR2 <400> 2871 Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2872 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 382 HC CDR3 <400> 2872 Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2873 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 383 LC CDR1 <400> 2873 Arg Ala Ser Gln Ser Val Ser Ser Phe Leu Ala 1 5 10 <210> 2874 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 383 LC CDR2 <400> 2874 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2875 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 383 LC CDR3 <400> 2875 Gln Gln Arg Ser Asn Trp Pro Lys Leu Thr 1 5 10 <210> 2876 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 383 HC CDR1 <400> 2876 Ser Tyr Ala Ile Ser 1 5 <210> 2877 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 383 HC CDR2 <400> 2877 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2878 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 383 HC CDR3 <400> 2878 Val Ser Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr 1 5 10 <210> 2879 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 384 LC CDR1 <400> 2879 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2880 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 384 LC CDR2 <400> 2880 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2881 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 384 LC CDR3 <400> 2881 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 2882 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 384 HC CDR1 <400> 2882 Thr Tyr Gly Met His 1 5 <210> 2883 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 384 HC CDR2 <400> 2883 Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2884 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 384 HC CDR3 <400> 2884 Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2885 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 385 LC CDR1 <400> 2885 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Ser 1 5 10 <210> 2886 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 385 LC CDR2 <400> 2886 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2887 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 385 LC CDR3 <400> 2887 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 2888 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 385 HC CDR1 <400> 2888 Gly Tyr Tyr Trp Ser 1 5 <210> 2889 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 385 HC CDR2 <400> 2889 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2890 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 385 HC CDR3 <400> 2890 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2891 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 386 LC CDR1 <400> 2891 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2892 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 386 LC CDR2 <400> 2892 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 2893 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 386 LC CDR3 <400> 2893 Gln Gln Ser Tyr Ser Thr Trp Thr 1 5 <210> 2894 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 386 HC CDR1 <400> 2894 Ser Tyr Ala Met His 1 5 <210> 2895 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 386 HC CDR2 <400> 2895 Val Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2896 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 386 HC CDR3 <400> 2896 Ala Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2897 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 387 LC CDR1 <400> 2897 Gln Ala Ser Gln Asp Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2898 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 387 LC CDR2 <400> 2898 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 2899 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 387 LC CDR3 <400> 2899 Gln Gln Ser Tyr Ser Thr Trp Thr 1 5 <210> 2900 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 387 HC CDR1 <400> 2900 Ser Tyr Ala Met His 1 5 <210> 2901 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 387 HC CDR2 <400> 2901 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2902 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 387 HC CDR3 <400> 2902 Ala Arg Gly Gly Ser Tyr Leu Tyr Gly Met Asp Val 1 5 10 <210> 2903 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 388 LC CDR1 <400> 2903 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2904 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 388 LC CDR2 <400> 2904 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 2905 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 388 LC CDR3 <400> 2905 Gln Gln Ser Tyr Ser Asn Pro Phe Thr 1 5 <210> 2906 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 388 HC CDR1 <400> 2906 Ser Tyr Ala Met His 1 5 <210> 2907 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 388 HC CDR2 <400> 2907 Val Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2908 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 388 HC CDR3 <400> 2908 Ala Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2909 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 389 LC CDR1 <400> 2909 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2910 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 389 LC CDR2 <400> 2910 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2911 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 389 LC CDR3 <400> 2911 Gln Gln Arg Ser Asn Trp Pro Pro Met Tyr Thr 1 5 10 <210> 2912 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 389 HC CDR1 <400> 2912 Ser Tyr Ala Ile Ile 1 5 <210> 2913 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 389 HC CDR2 <400> 2913 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2914 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 389 HC CDR3 <400> 2914 Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr 1 5 10 <210> 2915 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 390 LC CDR1 <400> 2915 Thr Gly Ser Arg Ser Asn Ile Gly Ile Asn Ser Val Asn 1 5 10 <210> 2916 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 390 LC CDR2 <400> 2916 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2917 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 390 LC CDR3 <400> 2917 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 2918 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 390 HC CDR1 <400> 2918 Gly Tyr Tyr Trp Ser 1 5 <210> 2919 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 390 HC CDR2 <400> 2919 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 2920 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 390 HC CDR3 <400> 2920 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 2921 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 391 LC CDR1 <400> 2921 Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2922 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 391 LC CDR2 <400> 2922 Ala Val Ser Lys Arg Pro Ser 1 5 <210> 2923 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 391 LC CDR3 <400> 2923 Ser Ser Tyr Thr Ser Ser Ser Gly Thr Leu Asn Val 1 5 10 <210> 2924 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 391 HC CDR1 <400> 2924 Thr Tyr Gly Met His 1 5 <210> 2925 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 391 HC CDR2 <400> 2925 Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2926 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 391 HC CDR3 <400> 2926 Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2927 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 392 LC CDR1 <400> 2927 Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn Phe Val Ser 1 5 10 <210> 2928 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 392 LC CDR2 <400> 2928 Asp Asn Asn Val Arg Pro Ser 1 5 <210> 2929 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 392 LC CDR3 <400> 2929 Ala Ala Trp Asp Thr Ser Leu Ser Ser Ser Trp Val 1 5 10 <210> 2930 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 392 HC CDR1 <400> 2930 Ser Tyr Tyr Met His 1 5 <210> 2931 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 392 HC CDR2 <400> 2931 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2932 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 392 HC CDR3 <400> 2932 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2933 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 393 LC CDR1 <400> 2933 Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 1 5 10 <210> 2934 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 393 LC CDR2 <400> 2934 Arg Ala Ser Thr Leu Gln Ser 1 5 <210> 2935 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 393 LC CDR3 <400> 2935 Gln Gln Tyr Lys Thr Tyr Pro Leu Thr 1 5 <210> 2936 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 393 HC CDR1 <400> 2936 Ser Tyr Gly Met His 1 5 <210> 2937 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 393 HC CDR2 <400> 2937 Ala Ile Trp His Asp Gly Tyr Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2938 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 393 HC CDR3 <400> 2938 Gly Ser Lys Ala Ala Asp Tyr 1 5 <210> 2939 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 394 LC CDR1 <400> 2939 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 2940 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 394 LC CDR2 <400> 2940 Gln Asp Ser Lys Arg Pro Ser 1 5 <210> 2941 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 394 LC CDR3 <400> 2941 Gln Ala Trp Asp Ser Ser Thr Val 1 5 <210> 2942 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 394 HC CDR1 <400> 2942 Thr Tyr Gly Met His 1 5 <210> 2943 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 394 HC CDR2 <400> 2943 Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2944 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 394 HC CDR3 <400> 2944 Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val 1 5 10 <210> 2945 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 395 LC CDR1 <400> 2945 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 2946 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 395 LC CDR2 <400> 2946 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2947 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 395 LC CDR3 <400> 2947 Gln Gln Arg Ser Asn Trp Pro Pro Met Tyr Thr 1 5 10 <210> 2948 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 395 HC CDR1 <400> 2948 Ser Tyr Ala Ile Ser 1 5 <210> 2949 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 395 HC CDR2 <400> 2949 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2950 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 395 HC CDR3 <400> 2950 Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Glu Tyr 1 5 10 <210> 2951 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 396 LC CDR1 <400> 2951 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 2952 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 396 LC CDR2 <400> 2952 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 2953 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 396 LC CDR3 <400> 2953 Ser Ser Tyr Thr Ser Ser Ser Thr Arg Tyr Val 1 5 10 <210> 2954 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 396 HC CDR1 <400> 2954 Ser Tyr Ala Met Asn 1 5 <210> 2955 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 396 HC CDR2 <400> 2955 Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2956 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 396 HC CDR3 <400> 2956 Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser Glu Tyr 1 5 10 15 Tyr Phe Asp Tyr 20 <210> 2957 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 397 LC CDR1 <400> 2957 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 2958 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 397 LC CDR2 <400> 2958 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 2959 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 397 LC CDR3 <400> 2959 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Val 1 5 10 <210> 2960 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 397 HC CDR1 <400> 2960 Asn Tyr Gly Ile Ser 1 5 <210> 2961 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 397 HC CDR2 <400> 2961 Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln 1 5 10 15 Gly <210> 2962 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 397 HC CDR3 <400> 2962 Pro Arg Gly Tyr Ser Gly Tyr Gly Ser Asn Trp Tyr Phe Asp Leu 1 5 10 15 <210> 2963 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 398 LC CDR1 <400> 2963 Arg Ala Ser Gln Ser Val Ser Ser Phe Leu Ala 1 5 10 <210> 2964 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 398 LC CDR2 <400> 2964 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 2965 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 398 LC CDR3 <400> 2965 Gln Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 1 5 10 <210> 2966 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 398 HC CDR1 <400> 2966 Ser Tyr Ala Ile Ser 1 5 <210> 2967 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 398 HC CDR2 <400> 2967 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 2968 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 398 HC CDR3 <400> 2968 Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr 1 5 10 <210> 2969 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 399 LC CDR1 <400> 2969 Arg Thr Thr Gln Asn Ile Asn Thr Tyr Leu Asn 1 5 10 <210> 2970 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 399 LC CDR2 <400> 2970 Ala Ala Ser Arg Leu Gln Ser 1 5 <210> 2971 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 399 LC CDR3 <400> 2971 Gln Arg Ser Tyr Ser Thr Pro Tyr Thr 1 5 <210> 2972 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 399 HC CDR1 <400> 2972 Ser Tyr Ala Met His 1 5 <210> 2973 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 399 HC CDR2 <400> 2973 Leu Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2974 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 399 HC CDR3 <400> 2974 Ala Thr Tyr Gly Ser Tyr Tyr Tyr Gly Met Asp Ala 1 5 10 <210> 2975 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 400 LC CDR1 <400> 2975 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 2976 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 400 LC CDR2 <400> 2976 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 2977 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 400 LC CDR3 <400> 2977 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 2978 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 400 HC CDR1 <400> 2978 Asn Tyr Ala Met Asn 1 5 <210> 2979 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 400 HC CDR2 <400> 2979 Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 2980 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> No. 400 HC CDR3 <400> 2980 Gly Tyr Ala Leu Asn Pro 1 5 <210> 2981 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 401 LC CDR1 <400> 2981 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Ser 1 5 10 <210> 2982 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 401 LC CDR2 <400> 2982 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2983 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 401 LC CDR3 <400> 2983 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2984 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 401 HC CDR1 <400> 2984 Ser Tyr Tyr Met His 1 5 <210> 2985 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 401 HC CDR2 <400> 2985 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2986 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 401 HC CDR3 <400> 2986 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2987 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 402 LC CDR1 <400> 2987 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2988 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 402 LC CDR2 <400> 2988 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 2989 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 402 LC CDR3 <400> 2989 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val 1 5 10 <210> 2990 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 402 HC CDR1 <400> 2990 Ser Tyr Tyr Met His 1 5 <210> 2991 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 402 HC CDR2 <400> 2991 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2992 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 402 HC CDR3 <400> 2992 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2993 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 403 LC CDR1 <400> 2993 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 2994 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 403 LC CDR2 <400> 2994 Asp Asn Ser Arg Arg Pro Ser 1 5 <210> 2995 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 403 LC CDR3 <400> 2995 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 2996 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 403 HC CDR1 <400> 2996 Ser Tyr Tyr Met His 1 5 <210> 2997 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 403 HC CDR2 <400> 2997 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 2998 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 403 HC CDR3 <400> 2998 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 2999 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 404 LC CDR1 <400> 2999 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3000 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 404 LC CDR2 <400> 3000 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 3001 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 404 LC CDR3 <400> 3001 Ala Ala Trp Asp Asp Ser Leu Ser Ala Trp Val 1 5 10 <210> 3002 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 404 HC CDR1 <400> 3002 Ser Tyr Tyr Met His 1 5 <210> 3003 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 404 HC CDR2 <400> 3003 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 3004 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 404 HC CDR3 <400> 3004 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 3005 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 405 LC CDR1 <400> 3005 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3006 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 405 LC CDR2 <400> 3006 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3007 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 405 LC CDR3 <400> 3007 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Trp Val 1 5 10 <210> 3008 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 405 HC CDR1 <400> 3008 Ser Tyr Tyr Met His 1 5 <210> 3009 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 405 HC CDR2 <400> 3009 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 3010 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 405 HC CDR3 <400> 3010 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 3011 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 406 LC CDR1 <400> 3011 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3012 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 406 LC CDR2 <400> 3012 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3013 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 406 LC CDR3 <400> 3013 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 3014 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 406 HC CDR1 <400> 3014 Ser Tyr Tyr Met His 1 5 <210> 3015 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 406 HC CDR2 <400> 3015 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Ser <210> 3016 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 406 HC CDR3 <400> 3016 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 3017 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 407 LC CDR1 <400> 3017 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3018 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 407 LC CDR2 <400> 3018 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3019 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 407 LC CDR3 <400> 3019 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 3020 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 407 HC CDR1 <400> 3020 Arg Tyr Ala Met Ser 1 5 <210> 3021 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 407 HC CDR2 <400> 3021 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3022 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 407 HC CDR3 <400> 3022 Val Arg Tyr Tyr Asp Phe Trp Ser Gly Trp Asp Val Met Asp Val 1 5 10 15 <210> 3023 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 408 LC CDR1 <400> 3023 Ser Gly Ser Ser Ser Ser Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3024 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 408 LC CDR2 <400> 3024 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3025 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 408 LC CDR3 <400> 3025 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 3026 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 408 HC CDR1 <400> 3026 Ser Tyr Tyr Met His 1 5 <210> 3027 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 408 HC CDR2 <400> 3027 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 3028 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 408 HC CDR3 <400> 3028 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 3029 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 409 LC CDR1 <400> 3029 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3030 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 409 LC CDR2 <400> 3030 Asp Asn Asn Val Arg Pro Ser 1 5 <210> 3031 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 409 LC CDR3 <400> 3031 Ala Ala Trp Asp Thr Ser Leu Ser Ser Ser Trp Val 1 5 10 <210> 3032 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 409 HC CDR1 <400> 3032 Ser Tyr Tyr Met His 1 5 <210> 3033 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 409 HC CDR2 <400> 3033 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 3034 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 409 HC CDR3 <400> 3034 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 3035 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 410 LC CDR1 <400> 3035 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3036 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 410 LC CDR2 <400> 3036 Asp Asn Asn Gln Arg Pro Ser 1 5 <210> 3037 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 410 LC CDR3 <400> 3037 Gly Thr Trp Asp Thr Ser Leu Ser Ala Trp Val 1 5 10 <210> 3038 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 410 HC CDR1 <400> 3038 Ser Tyr Tyr Met His 1 5 <210> 3039 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 410 HC CDR2 <400> 3039 Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe Gln 1 5 10 15 Gly <210> 3040 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 410 HC CDR3 <400> 3040 Gly Gly Arg His Ser Leu Asp Val 1 5 <210> 3041 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 411 LC CDR1 <400> 3041 Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn Tyr Val Ser 1 5 10 <210> 3042 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 411 LC CDR2 <400> 3042 Asp Asn Asn Arg Arg Pro Ser 1 5 <210> 3043 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 411 LC CDR3 <400> 3043 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Ala 1 5 10 <210> 3044 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 411 HC CDR1 <400> 3044 Ser Tyr Tyr Met His 1 5 <210> 3045 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 411 HC CDR2 <400> 3045 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3046 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No. 411 HC CDR3 <400> 3046 Gly Gly Asp His Gly Met Asp Val 1 5 <210> 3047 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 412 LC CDR1 <400> 3047 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3048 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 412 LC CDR2 <400> 3048 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3049 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 412 LC CDR3 <400> 3049 Ala Ala Trp Asp Asp Ser Leu Asn Gly Thr Val 1 5 10 <210> 3050 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 412 HC CDR1 <400> 3050 Gly Tyr Tyr Trp Ser 1 5 <210> 3051 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 412 HC CDR2 <400> 3051 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3052 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> No. 412 HC CDR3 <400> 3052 Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly Ile 1 5 10 15 Gly Met Asp Val 20 <210> 3053 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 413 LC CDR1 <400> 3053 Ser Gly Asp Val Leu Ala Lys Lys Tyr Ala Arg 1 5 10 <210> 3054 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 413 LC CDR2 <400> 3054 Lys Asp Ser Glu Arg Pro Ser 1 5 <210> 3055 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 413 LC CDR3 <400> 3055 Tyr Ser Ala Ala Asp Asn Asn Gly Val 1 5 <210> 3056 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 413 HC CDR1 <400> 3056 Ser Asp Ala Met His 1 5 <210> 3057 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 413 HC CDR2 <400> 3057 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3058 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 413 HC CDR3 <400> 3058 Glu Ala Thr Tyr Asp Ser Ser Gly Arg Pro Thr Gly Asp Tyr Gly Met 1 5 10 15 Asp Val <210> 3059 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 414 LC CDR1 <400> 3059 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3060 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 414 LC CDR2 <400> 3060 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3061 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 414 LC CDR3 <400> 3061 Gln Gln Arg Ser Asn Trp Pro Pro Arg Ile Thr 1 5 10 <210> 3062 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 414 HC CDR1 <400> 3062 Ser Tyr Ala Ile Ser 1 5 <210> 3063 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 414 HC CDR2 <400> 3063 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3064 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 414 HC CDR3 <400> 3064 Val Thr Gly Tyr Asp Gly Ser Gly Tyr Tyr Gln Asp Tyr 1 5 10 <210> 3065 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 415 LC CDR1 <400> 3065 Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3066 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 415 LC CDR2 <400> 3066 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3067 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 415 LC CDR3 <400> 3067 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 3068 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 415 HC CDR1 <400> 3068 Gly Tyr Tyr Trp Ser 1 5 <210> 3069 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 415 HC CDR2 <400> 3069 Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3070 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 415 HC CDR3 <400> 3070 Gly Arg Tyr Tyr Ser Ser Trp Tyr Gly Pro Arg Thr Trp Phe Asp Pro 1 5 10 15 <210> 3071 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 416 LC CDR1 <400> 3071 Arg Ala Ser Gln Ser Val Ser Thr Tyr Leu Ser 1 5 10 <210> 3072 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 416 LC CDR2 <400> 3072 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3073 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 416 LC CDR3 <400> 3073 Leu Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 1 5 10 <210> 3074 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 416 HC CDR1 <400> 3074 Ser Tyr Ala Ile Ser 1 5 <210> 3075 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 416 HC CDR2 <400> 3075 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3076 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 416 HC CDR3 <400> 3076 Ala Ser Gly Tyr Asp Ser Ser Gly Tyr Tyr Ser Asp Tyr 1 5 10 <210> 3077 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 417 LC CDR1 <400> 3077 Arg Ala Ser Gln Ser Val Ser Ser Phe Leu Ala 1 5 10 <210> 3078 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 417 LC CDR2 <400> 3078 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3079 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 417 LC CDR3 <400> 3079 Gln Gln Arg Ser Asn Trp Pro Ser Ile Thr 1 5 10 <210> 3080 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 417 HC CDR1 <400> 3080 Ser Tyr Ala Ile Ser 1 5 <210> 3081 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 417 HC CDR2 <400> 3081 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3082 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 417 HC CDR3 <400> 3082 Val Gly Thr Tyr Asp Ser Ser Gly Tyr Ser Phe Asp Tyr 1 5 10 <210> 3083 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 418 LC CDR1 <400> 3083 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3084 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 418 LC CDR2 <400> 3084 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3085 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 418 LC CDR3 <400> 3085 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 3086 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 418 HC CDR1 <400> 3086 Arg Tyr Ala Met Ser 1 5 <210> 3087 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 418 HC CDR2 <400> 3087 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3088 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 418 HC CDR3 <400> 3088 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 3089 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 419 LC CDR1 <400> 3089 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asp 1 5 10 <210> 3090 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 419 LC CDR2 <400> 3090 Asn Asn Asn Gln Arg Pro Ser 1 5 <210> 3091 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 419 LC CDR3 <400> 3091 Ala Ala Trp Asp Asp Ser Leu Asn Ala Pro Trp Val 1 5 10 <210> 3092 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 419 HC CDR1 <400> 3092 Ser Tyr Ala Met His 1 5 <210> 3093 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 419 HC CDR2 <400> 3093 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3094 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 419 HC CDR3 <400> 3094 Pro Arg Gly Gly Asn Tyr Arg Gly Ala Leu Asp Ile 1 5 10 <210> 3095 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 420 LC CDR1 <400> 3095 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3096 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 420 LC CDR2 <400> 3096 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3097 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 420 LC CDR3 <400> 3097 Gln Gln Tyr Gly Ser Ser Pro Pro Ile Thr 1 5 10 <210> 3098 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 420 HC CDR1 <400> 3098 Ser Tyr Ala Ile Ser 1 5 <210> 3099 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 420 HC CDR2 <400> 3099 Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3100 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 420 HC CDR3 <400> 3100 Asp Pro Thr Gly Trp Tyr Ser Gly Tyr Phe Asp Tyr 1 5 10 <210> 3101 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 421 LC CDR1 <400> 3101 Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Leu Val Ser 1 5 10 <210> 3102 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 421 LC CDR2 <400> 3102 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 3103 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 421 LC CDR3 <400> 3103 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val 1 5 10 <210> 3104 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 421 HC CDR1 <400> 3104 Asn Tyr Gly Met His 1 5 <210> 3105 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 421 HC CDR2 <400> 3105 Val Met Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3106 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 421 HC CDR3 <400> 3106 Pro Asp Asp Ser Ser Gly Tyr Tyr Pro Asp Tyr 1 5 10 <210> 3107 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 422 LC CDR1 <400> 3107 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 3108 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 422 LC CDR2 <400> 3108 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 3109 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 422 LC CDR3 <400> 3109 Ser Ser Tyr Thr Thr Ser Ser Thr Trp Val 1 5 10 <210> 3110 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 422 HC CDR1 <400> 3110 Glu Leu Ser Ile His 1 5 <210> 3111 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 422 HC CDR2 <400> 3111 Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3112 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 422 HC CDR3 <400> 3112 Ser Pro Ala Val Thr Thr Ala Gly Trp Phe Asp Pro 1 5 10 <210> 3113 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 423 LC CDR1 <400> 3113 Thr Gly Thr Arg Gly Asp Ile Gly Ala Tyr Asp Gly Val Ser 1 5 10 <210> 3114 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 423 LC CDR2 <400> 3114 Ala Val Thr Gln Arg Pro Ser 1 5 <210> 3115 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 423 LC CDR3 <400> 3115 Ser Ser Tyr Thr Ser Ser Ser Ser Trp Val 1 5 10 <210> 3116 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 423 HC CDR1 <400> 3116 Glu Leu Ser Met His 1 5 <210> 3117 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 423 HC CDR2 <400> 3117 Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3118 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 423 HC CDR3 <400> 3118 Ser Pro Ala Ile Ile Arg Val Asp Trp Phe Asp Pro 1 5 10 <210> 3119 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 424 LC CDR1 <400> 3119 Thr Gly Thr Arg Gly Asp Ile Gly Ala Tyr Asp Gly Val Ser 1 5 10 <210> 3120 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 424 LC CDR2 <400> 3120 Ala Val Thr Gln Arg Pro Ser 1 5 <210> 3121 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 424 LC CDR3 <400> 3121 Ser Ser Tyr Thr Ser Ser Ser Ser Trp Val 1 5 10 <210> 3122 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 424 HC CDR1 <400> 3122 Arg Tyr Ala Met Ser 1 5 <210> 3123 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 424 HC CDR2 <400> 3123 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3124 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 424 HC CDR3 <400> 3124 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 3125 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 425 LC CDR1 <400> 3125 Ser Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 3126 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 425 LC CDR2 <400> 3126 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 3127 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 425 LC CDR3 <400> 3127 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 3128 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 425 HC CDR1 <400> 3128 Ser Tyr Ala Met His 1 5 <210> 3129 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 425 HC CDR2 <400> 3129 Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3130 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 425 HC CDR3 <400> 3130 Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val 1 5 10 <210> 3131 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 426 LC CDR1 <400> 3131 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 3132 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 426 LC CDR2 <400> 3132 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 3133 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 426 LC CDR3 <400> 3133 Ser Ser Tyr Thr Ser Ser Ser Thr Pro Trp Val 1 5 10 <210> 3134 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 426 HC CDR1 <400> 3134 Ser Tyr Ala Met His 1 5 <210> 3135 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 426 HC CDR2 <400> 3135 Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3136 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 426 HC CDR3 <400> 3136 Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val 1 5 10 <210> 3137 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 427 LC CDR1 <400> 3137 Thr Gly Thr Asn Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 3138 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 427 LC CDR2 <400> 3138 Asp Val Thr Lys Arg Pro Ser 1 5 <210> 3139 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 427 LC CDR3 <400> 3139 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 3140 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 427 HC CDR1 <400> 3140 Ser Tyr Ala Met His 1 5 <210> 3141 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 427 HC CDR2 <400> 3141 Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3142 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 427 HC CDR3 <400> 3142 Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val 1 5 10 <210> 3143 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 428 LC CDR1 <400> 3143 Thr Gly Thr Ser Thr Asp Ile Gly Arg Tyr Asn Tyr Val Ser 1 5 10 <210> 3144 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 428 LC CDR2 <400> 3144 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 3145 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 428 LC CDR3 <400> 3145 Ser Ser Tyr Thr Ser Ser Ser Thr Tyr Ala 1 5 10 <210> 3146 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 428 HC CDR1 <400> 3146 Glu Val Ala Ile His 1 5 <210> 3147 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 428 HC CDR2 <400> 3147 Gly Phe Asp Pro Glu Asp Gly Glu Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3148 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 428 HC CDR3 <400> 3148 Gly Pro Val Leu Gly Leu Ser Lys Trp Leu Glu Phe Asp Pro 1 5 10 <210> 3149 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 429 LC CDR1 <400> 3149 Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr Asn Tyr Val Ser 1 5 10 <210> 3150 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 429 LC CDR2 <400> 3150 Asp Val Ser Lys Arg Pro Ser 1 5 <210> 3151 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 429 LC CDR3 <400> 3151 Asn Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 3152 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 429 HC CDR1 <400> 3152 Glu Val Ala Ile His 1 5 <210> 3153 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 429 HC CDR2 <400> 3153 Gly Phe Asp Pro Glu Asp Gly Glu Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3154 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 429 HC CDR3 <400> 3154 Gly Pro Val Leu Gly Leu Ser Lys Trp Leu Glu Phe Asp Pro 1 5 10 <210> 3155 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 430 LC CDR1 <400> 3155 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3156 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 430 LC CDR2 <400> 3156 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3157 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 430 LC CDR3 <400> 3157 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 3158 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 430 HC CDR1 <400> 3158 Arg Tyr Ala Met Ser 1 5 <210> 3159 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 430 HC CDR2 <400> 3159 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3160 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 430 HC CDR3 <400> 3160 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 3161 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 431 LC CDR1 <400> 3161 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3162 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 431 LC CDR2 <400> 3162 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3163 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 431 LC CDR3 <400> 3163 Glu Ala Trp Asp Ser Ser Leu Ser Ala Val Leu 1 5 10 <210> 3164 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 431 HC CDR1 <400> 3164 Arg Tyr Ala Met Ser 1 5 <210> 3165 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 431 HC CDR2 <400> 3165 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3166 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 431 HC CDR3 <400> 3166 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 3167 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 432 LC CDR1 <400> 3167 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3168 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 432 LC CDR2 <400> 3168 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3169 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 432 LC CDR3 <400> 3169 Gly Thr Trp Asp Thr Ser Leu Ser Ala Gly Val 1 5 10 <210> 3170 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 432 HC CDR1 <400> 3170 Arg Tyr Ala Met Ser 1 5 <210> 3171 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 432 HC CDR2 <400> 3171 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3172 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 432 HC CDR3 <400> 3172 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 3173 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 433 LC CDR1 <400> 3173 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3174 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 433 LC CDR2 <400> 3174 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3175 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 433 LC CDR3 <400> 3175 Gly Thr Trp Asp Ser Ser Leu Ser Asp Val Val 1 5 10 <210> 3176 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 433 HC CDR1 <400> 3176 Arg Tyr Ala Met Ser 1 5 <210> 3177 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 433 HC CDR2 <400> 3177 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3178 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 433 HC CDR3 <400> 3178 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 3179 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 434 LC CDR1 <400> 3179 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3180 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 434 LC CDR2 <400> 3180 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3181 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 434 LC CDR3 <400> 3181 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 3182 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 434 HC CDR1 <400> 3182 Arg Tyr Ala Met Ser 1 5 <210> 3183 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 434 HC CDR2 <400> 3183 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3184 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 434 HC CDR3 <400> 3184 Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp Tyr 1 5 10 15 <210> 3185 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 435 LC CDR1 <400> 3185 Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 3186 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 435 LC CDR2 <400> 3186 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 3187 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 435 LC CDR3 <400> 3187 Gln Gln Tyr Gly Ser Ser Pro Pro Thr 1 5 <210> 3188 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 435 HC CDR1 <400> 3188 Asn Tyr Val Ile Asn 1 5 <210> 3189 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 435 HC CDR2 <400> 3189 Gly Phe Ile Pro Val Phe Gly Ile Ala Asp Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3190 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 435 HC CDR3 <400> 3190 Ser Gly Leu Phe Asp Trp Leu Leu Pro Arg Ser Arg His Arg Asp Tyr 1 5 10 15 Phe Asp Tyr <210> 3191 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 436 LC CDR1 <400> 3191 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3192 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 436 LC CDR2 <400> 3192 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3193 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 436 LC CDR3 <400> 3193 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 3194 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 436 HC CDR1 <400> 3194 Ser Tyr Ala Ile Ser 1 5 <210> 3195 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 436 HC CDR2 <400> 3195 Gly Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3196 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 436 HC CDR3 <400> 3196 Asp Pro Thr Ser Arg Ser Thr Tyr Tyr Tyr Tyr Ser Gly Ser Tyr Tyr 1 5 10 15 Pro <210> 3197 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 437 LC CDR1 <400> 3197 Ser Gly Ser Gly Ser Asn Ile Gly Ser Asn Tyr Val His 1 5 10 <210> 3198 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 437 LC CDR2 <400> 3198 Arg Asn Ser Gln Arg Pro Ser 1 5 <210> 3199 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 437 LC CDR3 <400> 3199 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 3200 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 437 HC CDR1 <400> 3200 Ser Tyr Ala Ile Ser 1 5 <210> 3201 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 437 HC CDR2 <400> 3201 Gly Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3202 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 437 HC CDR3 <400> 3202 Asp Pro Thr Ser Arg Ser Thr Tyr Tyr Tyr Tyr Ser Gly Ser Tyr Tyr 1 5 10 15 Pro <210> 3203 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 438 LC CDR1 <400> 3203 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 3204 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 438 LC CDR2 <400> 3204 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 3205 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 438 LC CDR3 <400> 3205 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 3206 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 438 HC CDR1 <400> 3206 Glu Leu Pro Ile His 1 5 <210> 3207 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 438 HC CDR2 <400> 3207 Arg Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Asn Phe Gln 1 5 10 15 Gly <210> 3208 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 438 HC CDR3 <400> 3208 Asp Leu Thr Thr Val Thr Asn Pro Leu Asn Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 3209 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 439 LC CDR1 <400> 3209 Ser Gly Ser Ser Ser Asn Val Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 3210 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 439 LC CDR2 <400> 3210 Arg Asn Ser Gln Arg Pro Ser 1 5 <210> 3211 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 439 LC CDR3 <400> 3211 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Met 1 5 10 <210> 3212 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 439 HC CDR1 <400> 3212 Ser Tyr Gly Thr Thr 1 5 <210> 3213 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 439 HC CDR2 <400> 3213 Trp Ile Ser Gly Tyr Asn Glu Asn Ser Thr His Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3214 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 439 HC CDR3 <400> 3214 Asp Ala Leu Arg Tyr Asp Ile Leu Thr Gly Phe Thr Gly Phe Asp Tyr 1 5 10 15 <210> 3215 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 440 LC CDR1 <400> 3215 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3216 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 440 LC CDR2 <400> 3216 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3217 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 440 LC CDR3 <400> 3217 Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 1 5 10 <210> 3218 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 440 HC CDR1 <400> 3218 Ser Tyr Ala Met Ser 1 5 <210> 3219 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 440 HC CDR2 <400> 3219 Ala Ile Ser Gly Ser Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3220 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 440 HC CDR3 <400> 3220 Val Arg Tyr Tyr Asp Phe Trp Ser Gly Trp Asp Val Met Asp Val 1 5 10 15 <210> 3221 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 441 LC CDR1 <400> 3221 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 3222 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 441 LC CDR2 <400> 3222 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3223 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 441 LC CDR3 <400> 3223 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 3224 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 441 HC CDR1 <400> 3224 Ser Tyr Trp Met Ser 1 5 <210> 3225 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 441 HC CDR2 <400> 3225 Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 1 5 10 15 Gly <210> 3226 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 441 HC CDR3 <400> 3226 Gly Thr Tyr Tyr Tyr Asp Ser Ser Gly Pro Leu Asn Trp Phe Asp Pro 1 5 10 15 <210> 3227 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 442 LC CDR1 <400> 3227 Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3228 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 442 LC CDR2 <400> 3228 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3229 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 442 LC CDR3 <400> 3229 Gln Gln Gly Leu Thr 1 5 <210> 3230 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 442 HC CDR1 <400> 3230 Ser Tyr Ala Ile Ser 1 5 <210> 3231 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 442 HC CDR2 <400> 3231 Gly Ile Ile Pro Phe Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3232 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 442 HC CDR3 <400> 3232 Gly Lys Pro Tyr Tyr Cys Thr Gly Ser Thr Cys Tyr Gln Pro Leu Gly 1 5 10 15 Pro <210> 3233 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 443 LC CDR1 <400> 3233 Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 3234 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 443 LC CDR2 <400> 3234 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 3235 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 443 LC CDR3 <400> 3235 Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 1 5 <210> 3236 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 443 HC CDR1 <400> 3236 Ser Ser Pro Met His 1 5 <210> 3237 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 443 HC CDR2 <400> 3237 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3238 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 443 HC CDR3 <400> 3238 Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val 1 5 10 <210> 3239 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 444 LC CDR1 <400> 3239 Thr Gly Thr Ser Ser Asp Val Gly Asn Tyr Asn Tyr Val Ser 1 5 10 <210> 3240 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 444 LC CDR2 <400> 3240 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 3241 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 444 LC CDR3 <400> 3241 Ser Ser Tyr Thr Ser Ser Ser Gly Thr Leu Val 1 5 10 <210> 3242 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 444 HC CDR1 <400> 3242 Glu Leu Ser Ile His 1 5 <210> 3243 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 444 HC CDR2 <400> 3243 Gly Phe Asp Pro Glu Asn Gly Glu Thr Ile His Ala Gln Arg Phe Gln 1 5 10 15 Gly <210> 3244 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 444 HC CDR3 <400> 3244 Ser Thr Pro Met Ile Arg Ala Ser Trp Phe Asp Pro 1 5 10 <210> 3245 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 445 LC CDR1 <400> 3245 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Asn 1 5 10 <210> 3246 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 445 LC CDR2 <400> 3246 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3247 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 445 LC CDR3 <400> 3247 Ala Thr Trp Asp Asp Ser Leu Asn Gly Gln Val 1 5 10 <210> 3248 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 445 HC CDR1 <400> 3248 Asp Tyr Trp Met Ser 1 5 <210> 3249 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 445 HC CDR2 <400> 3249 Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 1 5 10 15 Gly <210> 3250 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> No. 445 HC CDR3 <400> 3250 Gly Tyr Ser Gly Asn Phe 1 5 <210> 3251 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 446 LC CDR1 <400> 3251 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 3252 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 446 LC CDR2 <400> 3252 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 3253 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 446 LC CDR3 <400> 3253 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 3254 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 446 HC CDR1 <400> 3254 Ser Tyr Ala Ile Ile 1 5 <210> 3255 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 446 HC CDR2 <400> 3255 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3256 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 446 HC CDR3 <400> 3256 Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr 1 5 10 <210> 3257 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 447 LC CDR1 <400> 3257 Arg Ala Ser Gln Ser Val Gly Arg Asn Tyr Leu Ala 1 5 10 <210> 3258 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 447 LC CDR2 <400> 3258 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 3259 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 447 LC CDR3 <400> 3259 Gln Gln Tyr Gly Ser Ser Pro Ile Thr 1 5 <210> 3260 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 447 HC CDR1 <400> 3260 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3261 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 447 HC CDR2 <400> 3261 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3262 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 447 HC CDR3 <400> 3262 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3263 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 448 LC CDR1 <400> 3263 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3264 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 448 LC CDR2 <400> 3264 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3265 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 448 LC CDR3 <400> 3265 His Gln Tyr Gly Thr Ser Pro Phe Thr 1 5 <210> 3266 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 448 HC CDR1 <400> 3266 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3267 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 448 HC CDR2 <400> 3267 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3268 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 448 HC CDR3 <400> 3268 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3269 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 449 LC CDR1 <400> 3269 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 3270 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 449 LC CDR2 <400> 3270 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 3271 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 449 LC CDR3 <400> 3271 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 3272 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 449 HC CDR1 <400> 3272 Ser Gly Gly Tyr Tyr Trp Ser 1 5 <210> 3273 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 449 HC CDR2 <400> 3273 Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3274 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 449 HC CDR3 <400> 3274 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3275 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 450 LC CDR1 <400> 3275 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 3276 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 450 LC CDR2 <400> 3276 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 3277 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 450 LC CDR3 <400> 3277 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 3278 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 450 HC CDR1 <400> 3278 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3279 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 450 HC CDR2 <400> 3279 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3280 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 450 HC CDR3 <400> 3280 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3281 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 451 LC CDR1 <400> 3281 Arg Ala Ser Gln Ser Val Asn Ser Tyr Ser Ala 1 5 10 <210> 3282 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 451 LC CDR2 <400> 3282 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3283 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 451 LC CDR3 <400> 3283 Gln Gln Tyr His Thr Ser Pro Ile Thr 1 5 <210> 3284 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 451 HC CDR1 <400> 3284 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3285 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 451 HC CDR2 <400> 3285 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3286 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 451 HC CDR3 <400> 3286 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3287 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 452 LC CDR1 <400> 3287 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3288 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 452 LC CDR2 <400> 3288 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3289 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 452 LC CDR3 <400> 3289 Gln Gln Tyr Gly Ser Ser Pro Ile Thr 1 5 <210> 3290 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 452 HC CDR1 <400> 3290 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3291 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 452 HC CDR2 <400> 3291 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3292 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 452 HC CDR3 <400> 3292 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3293 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 453 LC CDR1 <400> 3293 Thr Gly Thr Ser Ser Asn Val Gly Asp Tyr Asn Tyr Val Ser 1 5 10 <210> 3294 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 453 LC CDR2 <400> 3294 Asp Val Thr Asn Arg Pro Ser 1 5 <210> 3295 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 453 LC CDR3 <400> 3295 Ser Ser Tyr Thr Ser Gly Ser Thr Pro Val Val 1 5 10 <210> 3296 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 453 HC CDR1 <400> 3296 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3297 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 453 HC CDR2 <400> 3297 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3298 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 453 HC CDR3 <400> 3298 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3299 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 454 LC CDR1 <400> 3299 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 3300 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 454 LC CDR2 <400> 3300 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 3301 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 454 LC CDR3 <400> 3301 Gln Gln Tyr Gly Thr Ser Pro Leu Thr 1 5 <210> 3302 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 454 HC CDR1 <400> 3302 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3303 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 454 HC CDR2 <400> 3303 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3304 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 454 HC CDR3 <400> 3304 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3305 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 455 LC CDR1 <400> 3305 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 3306 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 455 LC CDR2 <400> 3306 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 3307 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 455 LC CDR3 <400> 3307 Gln Gln Tyr Gly Ser Ser Pro Leu Ala 1 5 <210> 3308 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 455 HC CDR1 <400> 3308 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3309 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 455 HC CDR2 <400> 3309 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3310 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 455 HC CDR3 <400> 3310 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3311 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 456 LC CDR1 <400> 3311 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3312 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 456 LC CDR2 <400> 3312 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3313 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 456 LC CDR3 <400> 3313 Gln Gln Tyr Gly Ser Ser Pro Gln Thr 1 5 <210> 3314 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 456 HC CDR1 <400> 3314 Gly Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3315 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 456 HC CDR2 <400> 3315 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3316 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 456 HC CDR3 <400> 3316 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3317 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 457 LC CDR1 <400> 3317 Arg Ala Ser Gln Ser Val Arg Asn Tyr Leu Ala 1 5 10 <210> 3318 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 457 LC CDR2 <400> 3318 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 3319 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 457 LC CDR3 <400> 3319 Gln Gln Tyr Gly Arg Ser Pro Leu Thr 1 5 <210> 3320 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 457 HC CDR1 <400> 3320 Gly Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3321 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 457 HC CDR2 <400> 3321 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3322 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 457 HC CDR3 <400> 3322 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3323 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 458 LC CDR1 <400> 3323 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3324 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 458 LC CDR2 <400> 3324 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 3325 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 458 LC CDR3 <400> 3325 Gln Gln His Gly Ser Ser Pro Phe Thr 1 5 <210> 3326 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 458 HC CDR1 <400> 3326 Gly Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3327 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 458 HC CDR2 <400> 3327 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3328 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 458 HC CDR3 <400> 3328 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 3329 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 459 LC CDR1 <400> 3329 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 3330 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 459 LC CDR2 <400> 3330 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 3331 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 459 LC CDR3 <400> 3331 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 3332 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 459 HC CDR1 <400> 3332 Ser Tyr Ala Ile Ser 1 5 <210> 3333 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 459 HC CDR2 <400> 3333 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3334 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 459 HC CDR3 <400> 3334 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 3335 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 460 LC CDR1 <400> 3335 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3336 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 460 LC CDR2 <400> 3336 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3337 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 460 LC CDR3 <400> 3337 Ser Thr Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 3338 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 460 HC CDR1 <400> 3338 Ser Tyr Ala Ile Ser 1 5 <210> 3339 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 460 HC CDR2 <400> 3339 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3340 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 460 HC CDR3 <400> 3340 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 3341 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 461 LC CDR1 <400> 3341 Ser Gly Leu Thr Ser Asn Ile Gly Ser Asn Phe Val Tyr 1 5 10 <210> 3342 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 461 LC CDR2 <400> 3342 Arg Asn Asn Glu Arg Pro Ser 1 5 <210> 3343 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 461 LC CDR3 <400> 3343 Ala Ala Trp Asp Asp Thr Leu Val Gly Arg Val 1 5 10 <210> 3344 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 461 HC CDR1 <400> 3344 Ser Tyr Ala Ile Ser 1 5 <210> 3345 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 461 HC CDR2 <400> 3345 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 3346 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 461 HC CDR3 <400> 3346 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 3347 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 462 LC CDR1 <400> 3347 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3348 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 462 LC CDR2 <400> 3348 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3349 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 462 LC CDR3 <400> 3349 Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val 1 5 10 <210> 3350 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 462 HC CDR1 <400> 3350 Ser His Trp Ile Ala 1 5 <210> 3351 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 462 HC CDR2 <400> 3351 Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3352 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 462 HC CDR3 <400> 3352 Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser 1 5 10 <210> 3353 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 463 LC CDR1 <400> 3353 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3354 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 463 LC CDR2 <400> 3354 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3355 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 463 LC CDR3 <400> 3355 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 3356 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 463 HC CDR1 <400> 3356 Ser His Trp Ile Ala 1 5 <210> 3357 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 463 HC CDR2 <400> 3357 Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3358 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 463 HC CDR3 <400> 3358 Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser 1 5 10 <210> 3359 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 464 LC CDR1 <400> 3359 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3360 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 464 LC CDR2 <400> 3360 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3361 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 464 LC CDR3 <400> 3361 Ala Ala Trp Asp Asp Ser Leu Asn Gly Ser Val Val 1 5 10 <210> 3362 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 464 HC CDR1 <400> 3362 Ser Tyr Trp Ile Ala 1 5 <210> 3363 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 464 HC CDR2 <400> 3363 Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3364 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 464 HC CDR3 <400> 3364 Gly Pro Asn Leu Tyr Asn Trp Phe Asp Phe 1 5 10 <210> 3365 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 465 LC CDR1 <400> 3365 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3366 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 465 LC CDR2 <400> 3366 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3367 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 465 LC CDR3 <400> 3367 Ala Ala Trp Asp Asp Ser Leu Asn Gly His Val Val 1 5 10 <210> 3368 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 465 HC CDR1 <400> 3368 Ser Tyr Trp Ile Ala 1 5 <210> 3369 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 465 HC CDR2 <400> 3369 Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3370 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 465 HC CDR3 <400> 3370 Gly Pro Asn Leu Tyr Asn Trp Phe Asp Phe 1 5 10 <210> 3371 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 466 LC CDR1 <400> 3371 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3372 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 466 LC CDR2 <400> 3372 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3373 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 466 LC CDR3 <400> 3373 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 3374 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 466 HC CDR1 <400> 3374 Ser His Trp Ile Ala 1 5 <210> 3375 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 466 HC CDR2 <400> 3375 Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3376 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 466 HC CDR3 <400> 3376 Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser 1 5 10 <210> 3377 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 467 LC CDR1 <400> 3377 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 3378 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 467 LC CDR2 <400> 3378 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 3379 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 467 LC CDR3 <400> 3379 Gln Gln Tyr Tyr Ser Thr Pro Phe Thr 1 5 <210> 3380 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 467 HC CDR1 <400> 3380 Asp Tyr Tyr Ile Gln 1 5 <210> 3381 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 467 HC CDR2 <400> 3381 Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe Gln 1 5 10 15 Gly <210> 3382 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 467 HC CDR3 <400> 3382 Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro 1 5 10 <210> 3383 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 468 LC CDR1 <400> 3383 Arg Ala Ser Gln Gly Ile Ser Asn Ser Leu Ala 1 5 10 <210> 3384 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 468 LC CDR2 <400> 3384 Ala Ala Ser Arg Leu Glu Ser 1 5 <210> 3385 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 468 LC CDR3 <400> 3385 Gln Gln Tyr Tyr Ser Thr Pro Phe Thr 1 5 <210> 3386 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 468 HC CDR1 <400> 3386 Asp Tyr Tyr Ile Gln 1 5 <210> 3387 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 468 HC CDR2 <400> 3387 Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe Gln 1 5 10 15 Gly <210> 3388 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 468 HC CDR3 <400> 3388 Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro 1 5 10 <210> 3389 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 469 LC CDR1 <400> 3389 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3390 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 469 LC CDR2 <400> 3390 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3391 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 469 LC CDR3 <400> 3391 Ala Ala Trp Asp Asp Ser Leu Asn Ser Gly Val 1 5 10 <210> 3392 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 469 HC CDR1 <400> 3392 Ser Asn Trp Ile Gly 1 5 <210> 3393 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 469 HC CDR2 <400> 3393 Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3394 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 469 HC CDR3 <400> 3394 Thr Tyr Gly Ser Gly Ser Tyr Ser Asp Phe Asp Tyr 1 5 10 <210> 3395 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 470 LC CDR1 <400> 3395 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3396 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 470 LC CDR2 <400> 3396 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3397 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 470 LC CDR3 <400> 3397 Ala Ala Trp Asp Asp Ser Leu Asn Gly Gly Val 1 5 10 <210> 3398 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 470 HC CDR1 <400> 3398 Ser Asn Trp Ile Gly 1 5 <210> 3399 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 470 HC CDR2 <400> 3399 Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3400 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 470 HC CDR3 <400> 3400 Thr Tyr Gly Ser Gly Ser Tyr Ser Asp Phe Asp Tyr 1 5 10 <210> 3401 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 471 LC CDR1 <400> 3401 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 3402 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 471 LC CDR2 <400> 3402 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 3403 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 471 LC CDR3 <400> 3403 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Trp Val 1 5 10 <210> 3404 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 471 HC CDR1 <400> 3404 Asp Tyr Ala Met Ser 1 5 <210> 3405 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 471 HC CDR2 <400> 3405 Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Asn Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3406 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 471 HC CDR3 <400> 3406 Val Tyr Cys Gly Asp Asp Cys Tyr Pro Val Val Gly Thr Pro Gly Asp 1 5 10 15 Ala Phe Asp <210> 3407 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 472 LC CDR1 <400> 3407 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 3408 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 472 LC CDR2 <400> 3408 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 3409 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 472 LC CDR3 <400> 3409 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val 1 5 10 <210> 3410 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 472 HC CDR1 <400> 3410 Asp Tyr Ala Met Ser 1 5 <210> 3411 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 472 HC CDR2 <400> 3411 Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Asn Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 3412 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 472 HC CDR3 <400> 3412 Val Tyr Cys Gly Asp Asp Cys Tyr Pro Val Val Gly Thr Pro Gly Asp 1 5 10 15 Ala Phe Asp <210> 3413 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 473 LC CDR1 <400> 3413 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3414 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 473 LC CDR2 <400> 3414 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3415 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 473 LC CDR3 <400> 3415 Ala Ala Trp Asp Asp Ser Leu Met Gln Gly Val 1 5 10 <210> 3416 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 473 HC CDR1 <400> 3416 Asn Tyr Trp Ile Ala 1 5 <210> 3417 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 473 HC CDR2 <400> 3417 Ile Ile Tyr Pro Tyr Asp Ser Asp Thr Arg Lys Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3418 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 473 HC CDR3 <400> 3418 Gln Asp Ser Gly Thr Tyr Gly Trp Ile Asp Tyr 1 5 10 <210> 3419 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 474 LC CDR1 <400> 3419 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 3420 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 474 LC CDR2 <400> 3420 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 3421 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 474 LC CDR3 <400> 3421 Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Trp Val 1 5 10 <210> 3422 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 474 HC CDR1 <400> 3422 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 3423 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 474 HC CDR2 <400> 3423 Asn Phe Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 3424 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 474 HC CDR3 <400> 3424 Gln Glu Trp Leu Arg Gly Gly Phe Asp Asp 1 5 10 <210> 3425 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 475 LC CDR1 <400> 3425 Ser Gly Ser Ser Ser Asn Val Gly Ser Asn Ile Val Asn 1 5 10 <210> 3426 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 475 LC CDR2 <400> 3426 Asn Asn Asn Gln Arg Pro Ser 1 5 <210> 3427 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 475 LC CDR3 <400> 3427 Ala Ala Trp Asp Asp Ser Leu Asn Ala Trp Val 1 5 10 <210> 3428 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 475 HC CDR1 <400> 3428 Asn His Trp Ile Ala 1 5 <210> 3429 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 475 HC CDR2 <400> 3429 Ile Ile Tyr Pro Tyr Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe Gln 1 5 10 15 Gly <210> 3430 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 475 HC CDR3 <400> 3430 Asn Pro Thr Val Thr Asn Trp Phe Asp Ser 1 5 10 <210> 3431 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 476 LC CDR1 <400> 3431 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 3432 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 476 LC CDR2 <400> 3432 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 3433 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 476 LC CDR3 <400> 3433 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Pro Asn Trp Val 1 5 10 <210> 3434 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 476 HC CDR1 <400> 3434 Ser Tyr Ala Ile Ser 1 5 <210> 3435 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 476 HC CDR2 <400> 3435 Gly Ile Ile Pro Phe Phe Gly Thr Ser Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3436 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 476 HC CDR3 <400> 3436 Gly Gln Phe Ser Asp Ser Ser Gly Tyr Gln His Pro Tyr Tyr Asp Tyr 1 5 10 15 Gly Met Asp <210> 3437 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 477 LC CDR1 <400> 3437 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 3438 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 477 LC CDR2 <400> 3438 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 3439 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 477 LC CDR3 <400> 3439 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Val 1 5 10 <210> 3440 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 477 HC CDR1 <400> 3440 Thr His Ala Leu Ser 1 5 <210> 3441 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 477 HC CDR2 <400> 3441 Gly Ile Ile Pro Ile Phe Gly Pro Ala Asp Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3442 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 477 HC CDR3 <400> 3442 Gly Leu Ser Leu Gly Phe Cys Ser Ala Gly Ser Cys Tyr Asp Tyr Leu 1 5 10 15 Asp Tyr <210> 3443 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 478 LC CDR1 <400> 3443 Ser Gly Ser Ser Ser Asp Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 3444 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 478 LC CDR2 <400> 3444 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 3445 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 478 LC CDR3 <400> 3445 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 3446 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 478 HC CDR1 <400> 3446 Asn Tyr Ala Ile Asn 1 5 <210> 3447 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 478 HC CDR2 <400> 3447 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3448 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> No. 478 HC CDR3 <400> 3448 Asp Arg Tyr Pro Gly Tyr Tyr Asp Ile Leu Thr Gly Gln Ile Gly Thr 1 5 10 15 Gly Glu Arg Asn Ala Met Asp Val 20 <210> 3449 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 479 LC CDR1 <400> 3449 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 3450 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 479 LC CDR2 <400> 3450 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 3451 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 479 LC CDR3 <400> 3451 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 3452 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 479 HC CDR1 <400> 3452 Asn Tyr Pro Leu Thr 1 5 <210> 3453 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 479 HC CDR2 <400> 3453 Gly Ile Ile Pro Ile Ile Gly Ala Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3454 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No. 479 HC CDR3 <400> 3454 Gly Arg Gly Tyr Ser Gly Tyr Gly Ala Ala Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 3455 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 480 LC CDR1 <400> 3455 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 3456 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 480 LC CDR2 <400> 3456 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 3457 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 480 LC CDR3 <400> 3457 Gln Val Trp Asp Ser Ser Ser Asp His Trp Val 1 5 10 <210> 3458 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 480 HC CDR1 <400> 3458 Ser Tyr Tyr Ile His 1 5 <210> 3459 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 480 HC CDR2 <400> 3459 Phe Ile Asn Pro Ser Asp Val Thr Thr Tyr Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 3460 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 480 HC CDR3 <400> 3460 Ser Arg Ile Ala Pro Thr Glu Asp Phe Phe Asp Tyr 1 5 10 <210> 3461 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 291 LC variable region <400> 3461 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Ser Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Arg Leu 85 90 95 Ser Ala Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3462 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 291 HC variable region <400> 3462 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Ser Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3463 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 292 LC variable region <400> 3463 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Phe Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Glu Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3464 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 292 HC variable region <400> 3464 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3465 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 293 LC variable region <400> 3465 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3466 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 293 HC variable region <400> 3466 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Arg Tyr Tyr Asp Phe Trp Ser Gly Trp Asp Val Met Asp 100 105 110 Val Trp Gly Gin Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3467 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 294 LC variable region <400> 3467 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3468 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 294 HC variable region <400> 3468 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3469 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 295 LC variable region <400> 3469 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3470 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 295 HC variable region <400> 3470 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 3471 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 296 LC variable region <400> 3471 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3472 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 296 HC variable region <400> 3472 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Ala Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3473 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 297 LC variable region <400> 3473 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3474 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 297 HC variable region <400> 3474 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Gly Pro Phe Glu Arg Lys 20 25 30 Val Ile Ala Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 35 40 45 Gly Gly His Ala Pro Phe Val Arg Lys Pro Thr Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Ala Asp Asp Ser Thr Ala Thr Ala Phe 65 70 75 80 Met Glu Leu Ser Ser Leu Gly Tyr Gly Asp Thr Gly Val Tyr Tyr Cys 85 90 95 Ala Thr Lys Ala Val Thr Thr Tyr Ser Gly Phe Asp Asn Trp Gly Gln 100 105 110 Gly Thr Leu Val Phe Val Ser Thr 115 120 <210> 3475 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 298 LC variable region <400> 3475 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Ser 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu 35 40 45 Tyr Ala Ala Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3476 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 298 HC variable region <400> 3476 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 20 25 30 Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Thr Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asp Ser Lys Asn Met 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Thr His Ser Arg Pro Asp Tyr Trp Gly Gin Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 3477 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 299 LC variable region <400> 3477 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3478 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 299 HC variable region <400> 3478 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Gly Pro Phe Glu Arg Lys 20 25 30 Val Ile Ala Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 35 40 45 Gly Gly His Ala Pro Phe Val Arg Lys Pro Thr Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Ala Asp Asp Ser Thr Ser Thr Ala Phe 65 70 75 80 Met Glu Leu Ser Thr Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Lys Ala Val Thr Thr Tyr Ser Gly Phe Asp Thr Trp Gly Gln 100 105 110 Gly Thr Leu Val Leu Val Ser Ala 115 120 <210> 3479 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 300 LC variable region <400> 3479 Glu Leu Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Leu 35 40 45 Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Ala Ala Val Tyr Tyr Cys Leu Gln Tyr Phe Thr Ile Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3480 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 300 HC variable region <400> 3480 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Ala 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Lys Thr Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 50 55 60 Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Thr Thr Phe Ser Thr Pro Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 3481 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 301 LC variable region <400> 3481 Glu Leu Ala Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3482 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 301 HC variable region <400> 3482 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Arg Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ile Arg Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Lys Val Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Val Asn 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Gly Ser Thr Trp Tyr Gly Gly Asn Trp Phe Asp Pro Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3483 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> No. 302 LC variable region <400> 3483 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Val Ser Pro Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Ser Gly Asp Val Leu Ala Lys Lys Tyr Ala 20 25 30 Arg Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Ala Ala Asp Asn Asn Gly Val 85 90 95 Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 <210> 3484 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No. 302 HC variable region <400> 3484 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asp 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ala Thr Tyr Asp Ser Ser Gly Arg Pro Thr Gly Asp Tyr 100 105 110 Gly Met Asp Val Trp Gly Gin Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3485 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 303 LC variable region <400> 3485 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3486 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 303 HC variable region <400> 3486 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3487 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No. 304 LC variable region <400> 3487 Glu Leu Ala Leu Asn Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala His Lys Leu 35 40 45 Met Met Tyr Asp Val Ser Asn Arg Pro Ser Gly Ala Tyr Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Ala Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Ser His Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3488 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 304 HC variable region <400> 3488 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Ser Ser Tyr Ala 20 25 30 Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 35 40 45 Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Lys Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser Glu 100 105 110 Tyr Tyr Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3489 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 305 LC variable region <400> 3489 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3490 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> No. 305 HC variable region <400> 3490 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Arg Gly 20 25 30 Asp Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 50 55 60 Lys Ser Arg Val Thr Ile Ser Ala Asp Thr Ser Lys Asn Gln Phe Ser 65 70 75 80 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ala Tyr Tyr Cys 85 90 95 Ala Arg His Gly Thr Ser Gly Tyr Tyr Tyr Pro Asn Trp Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3491 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 306 LC variable region <400> 3491 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Ala Ser Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3492 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 306 HC variable region <400> 3492 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3493 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 307 LC variable region <400> 3493 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Thr Asp Asn Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3494 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 307 HC variable region <400> 3494 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3495 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 308 LC variable region <400> 3495 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3496 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 308 HC variable region <400> 3496 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3497 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 309 LC variable region <400> 3497 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Arg Asp Asp Ser Leu 85 90 95 Asn Gly Ala Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3498 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 309 HC variable region <400> 3498 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3499 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 310 LC variable region <400> 3499 Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3500 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 310 HC variable region <400> 3500 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3501 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 311 LC variable region <400> 3501 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro Arg 85 90 95 Arg Val Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3502 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 311 HC variable region <400> 3502 Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3503 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 312 LC variable region <400> 3503 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Gln Val Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3504 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 312 HC variable region <400> 3504 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3505 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 313 LC variable region <400> 3505 Glu Leu Gly Gln Thr Gln Gln Leu Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3506 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 313 HC variable region <400> 3506 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr 100 105 110 Tyr Ala Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3507 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 314 LC variable region <400> 3507 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3508 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 314 HC variable region <400> 3508 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 20 25 30 Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Ser Pro Ala Val Thr Thr Ala Gly Trp Phe Asp Pro Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3509 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 315 LC variable region <400> 3509 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Thr Asn 20 25 30 Thr Val Asn Trp Tyr Gln His Leu Pro Gly Met Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Leu Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3510 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 315 HC variable region <400> 3510 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3511 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 316 LC variable region <400> 3511 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Gly Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3512 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 316 HC variable region <400> 3512 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Phe Tyr 20 25 30 Ala Ile Ser Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Lys Tyr Ala Gln Arg Phe 50 55 60 Gln Asp Arg Val Thr Phe Ile Ala Asp Asp Thr Ser Thr Ala Tyr Met 65 70 75 80 Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Gly Trp Ile Tyr Arg Gly Asn Trp Phe Asp Pro Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3513 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 317 LC variable region <400> 3513 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Trp Val Leu Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3514 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 317 HC variable region <400> 3514 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Thr Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Asn Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ser Ser His Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro 100 105 110 Arg Phe Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 115 120 125 Ser <210> 3515 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 318 LC variable region <400> 3515 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 85 90 95 Asn Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3516 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 318 HC variable region <400> 3516 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser 100 105 110 Glu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3517 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 319 LC variable region <400> 3517 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Leu Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3518 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 319 HC variable region <400> 3518 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser 100 105 110 Glu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3519 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 320 LC variable region <400> 3519 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3520 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 320 HC variable region <400> 3520 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Val Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3521 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 321 LC variable region <400> 3521 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Leu Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3522 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 321 HC variable region <400> 3522 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ile Ser Tyr 20 25 30 Trp Ile Val Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Thr Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Ile Tyr Asn Trp Phe Asp Ser Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3523 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 322 LC variable region <400> 3523 Glu Leu Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3524 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 322 HC variable region <400> 3524 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Phe Ile Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ile Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Arg Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Pro Leu Thr Gly Thr Thr Leu Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3525 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 323 LC variable region <400> 3525 Glu Leu Val Leu Thr Gln Ser Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 35 40 45 Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 85 90 95 Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 3526 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 323 HC variable region <400> 3526 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Arg Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr 100 105 110 Tyr Ala Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3527 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 324 LC variable region <400> 3527 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3528 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 324 HC variable region <400> 3528 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Ser Asn Tyr 20 25 30 Pro Leu Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Gly Ile Ile Pro Ile Ile Gly Ala Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Phe 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Arg Gly Tyr Ser Gly Tyr Gly Ala Ala Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 3529 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No. 325 LC variable region <400> 3529 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3530 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 325 HC variable region <400> 3530 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Gly Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Leu Tyr Tyr Tyr Asp Arg Ser Gly Tyr Pro Ile Ser Glu 100 105 110 Asp Tyr Phe Asp Tyr Trp Gly Gly Gly Thr Leu Val Thr Val Ser Ala 115 120 125 <210> 3531 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 326 LC variable region <400> 3531 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3532 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 326 HC variable region <400> 3532 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Ala Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3533 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 327 LC variable region <400> 3533 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Thr Asn Asn Arg Arg Pro Ser Gly Ala Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3534 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 327 HC variable region <400> 3534 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Arg Gly Ser Gly Tyr Ser Phe Thr Ser His 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3535 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 328 LC variable region <400> 3535 Glu Leu Val Val Thr Gln Glu Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 85 90 95 Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 <210> 3536 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 328 HC variable region <400> 3536 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Asn Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Tyr Cys Gly Asp Asp Cys Tyr Pro Val Val Gly Thr Pro 100 105 110 Gly Asp Ala Phe Asp Ile Trp Gly Gly Gly Thr Met Val Thr Val Ser 115 120 125 Ser <210> 3537 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 329 LC variable region <400> 3537 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Gly Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3538 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 329 HC variable region <400> 3538 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr 100 105 110 Tyr Ala Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3539 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 330 LC variable region <400> 3539 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Gln 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3540 <211> 130 <212> PRT <213> Artificial Sequence <220> <223> No. 330 HC variable region <400> 3540 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Ser 20 25 30 Ser Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 35 40 45 Glu Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro 50 55 60 Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 65 70 75 80 Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr 85 90 95 Tyr Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr 100 105 110 Ser Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val 115 120 125 Ser Ser 130 <210> 3541 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 331 LC variable region <400> 3541 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3542 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 331 HC variable region <400> 3542 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Tyr Ser Ser Trp Tyr Gly Pro Arg Thr Trp Phe Asp 100 105 110 Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3543 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 332 LC variable region <400> 3543 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3544 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 332 HC variable region <400> 3544 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Phe Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 85 90 95 Cys Ala Arg Gln Glu Trp Leu Arg Gly Gly Phe Asp Asp Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3545 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 333 LC variable region <400> 3545 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 20 25 30 Tyr Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3546 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No. 333 HC variable region <400> 3546 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Arg Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 3547 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 334 LC variable region <400> 3547 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser 85 90 95 Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3548 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 334 HC variable region <400> 3548 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3549 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 335 LC variable region <400> 3549 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3550 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 335 HC variable region <400> 3550 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Gly Ile Pro Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Arg Gly Tyr Ser Gly Tyr Gly Ala Asn Trp Tyr Phe Asp 100 105 110 Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3551 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 336 LC variable region <400> 3551 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3552 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 336 HC variable region <400> 3552 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Arg Ala Ser Gly Tyr Ala Phe Thr Arg Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Leu Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Gly Ile Ala Val Ala Gly Thr Pro Ile Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Pro 115 120 <210> 3553 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 337 LC variable region <400> 3553 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asp 20 25 30 Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Thr Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Thr Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3554 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 337 HC variable region <400> 3554 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Tyr Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3555 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No. 338 LC variable region <400> 3555 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Gln 100 105 110 <210> 3556 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 338 HC variable region <400> 3556 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Pro Gly Gly Ser Thr Phe Phe Ala Asp Ser Val Gln 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ser Tyr Asp Phe Leu Thr Asp Tyr Thr Asp Ala Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 3557 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 339 LC variable region <400> 3557 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Pro Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3558 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 339 HC variable region <400> 3558 Glu Val Gln Leu Leu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Gly Val Val Thr Ala Asp Trp Tyr Phe Asp Leu Trp Gly Arg 100 105 110 Gly Thr Leu Ala Thr Val Ser Ser 115 120 <210> 3559 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No. 340 LC variable region <400> 3559 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3560 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 340 HC variable region <400> 3560 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Thr Phe Ser Arg Tyr 20 25 30 Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Leu Leu Gly Thr Ala Asp Tyr Pro Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Thr Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Thr Leu Tyr Tyr Tyr Asp Arg Ser Gly Asn Ala Arg Thr Asp 100 105 110 Asp Tyr Phe Asp His Trp Ala Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3561 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 341 LC variable region <400> 3561 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3562 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 341 HC variable region <400> 3562 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Val Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3563 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 342 LC variable region <400> 3563 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3564 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 342 HC variable region <400> 3564 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3565 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 343 LC variable region <400> 3565 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3566 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 343 HC variable region <400> 3566 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Pro Gly Gly Ser Thr Phe Phe Ala Asp Ser Val Gln 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ser Tyr Asp Phe Leu Thr Asp Tyr Thr Asp Ala Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 3567 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 344 LC variable region <400> 3567 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3568 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 344 HC variable region <400> 3568 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Arg Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Glu Glu Leu Gly Pro Tyr Ser Asn Arg Trp Tyr Ser Ser Ser Ser 100 105 110 Asp Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3569 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 345 LC variable region <400> 3569 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3570 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 345 HC variable region <400> 3570 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Ser Ser 20 25 30 Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Val Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Phe Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Asp His Ile Val Ser Pro Leu Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3571 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 346 LC variable region <400> 3571 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3572 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 346 HC variable region <400> 3572 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Pro Gly Gly Ser Thr Phe Phe Ala Asp Ser Val Gln 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ser Tyr Asp Phe Leu Thr Asp Tyr Thr Asp Ala Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 3573 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 347 LC variable region <400> 3573 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Ile 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3574 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 347 HC variable region <400> 3574 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Tyr Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3575 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 348 LC variable region <400> 3575 Glu Leu Ala Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Pro Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Ser His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Ile Leu Tyr Glu Val Ser Asp Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3576 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 348 HC variable region <400> 3576 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3577 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 349 LC variable region <400> 3577 Glu Leu Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3578 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 349 HC variable region <400> 3578 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Pro Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3579 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 350 LC variable region <400> 3579 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Ala Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3580 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 350 HC variable region <400> 3580 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ile Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3581 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 351 LC variable region <400> 3581 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 35 40 45 Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp Arg 85 90 95 Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 3582 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 351 HC variable region <400> 3582 Glu Val Gln Leu Leu Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Thr Thr Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asp Ile Gly Ser Gly Asp Arg Pro Asp Ala Phe His Leu Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 3583 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 352 LC variable region <400> 3583 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Glu Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3584 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 352 HC variable region <400> 3584 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3585 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 353 LC variable region <400> 3585 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3586 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 353 HC variable region <400> 3586 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser Ser 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Gly Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3587 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 354 LC variable region <400> 3587 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Asn Arg Ser Asp Ile Gly Gly Tyr 20 25 30 Asn Ser Leu Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Ile Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Tyr Thr Ser Lys 85 90 95 Asn Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3588 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 354 HC variable region <400> 3588 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser Ser 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3589 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 355 LC variable region <400> 3589 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3590 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 355 HC variable region <400> 3590 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser Ser 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3591 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 356 LC variable region <400> 3591 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3592 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 356 HC variable region <400> 3592 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Ser Ser Ser 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3593 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 357 LC variable region <400> 3593 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Ala Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3594 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 357 HC variable region <400> 3594 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser Ser 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3595 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 358 LC variable region <400> 3595 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3596 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 358 HC variable region <400> 3596 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Gly Pro Phe Glu Arg Lys 20 25 30 Val Ile Ala Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 35 40 45 Gly Gly His Ala Pro Phe Val Arg Lys Pro Thr Tyr Ala Arg Lys Phe 50 55 60 Gln Gly Arg Val Thr Leu Thr Ala Asp Asp Ser Thr Ser Thr Ala Phe 65 70 75 80 Met Glu Phe Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Thr Lys Ala Val Thr Thr Tyr Ser Gly Phe Asp Asn Trp Gly Gln 100 105 110 Gly Thr Leu Val Phe Val Ser Ala 115 120 <210> 3597 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 359 LC variable region <400> 3597 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Asn Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Pro Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3598 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> No. 359 HC variable region <400> 3598 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Pro Thr Ser Arg Ser Thr Tyr Tyr Tyr Tyr Ser Gly Ser 100 105 110 Tyr Tyr Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3599 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 360 LC variable region <400> 3599 Glu Leu Ala Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Thr Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Ser Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3600 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 360 HC variable region <400> 3600 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Met Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Asp Ser Ser Gly Tyr Tyr Pro Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3601 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 361 LC variable region <400> 3601 Glu Leu Ala Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Arg Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3602 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 361 HC variable region <400> 3602 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3603 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 362 LC variable region <400> 3603 Glu Leu Gln Met Thr Gln Ser Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Ser Tyr Arg Pro Ser Gly Val Ser Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Arg 65 70 75 80 Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ala Leu 85 90 95 Arg Gly Pro Leu Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 3604 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No. 362 HC variable region <400> 3604 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Gly Ile Ser Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Ala Thr Thr Lys Phe Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Trp Gly Leu Arg Leu Phe Gly Glu Phe Ser Val Trp Phe 100 105 110 Asp Pro Trp Gly Leu Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3605 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 363 LC variable region <400> 3605 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Asp Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3606 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No. 363 HC variable region <400> 3606 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Gly Ser Tyr 20 25 30 Gly Ile Ser Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Ala Thr Thr Lys Phe Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Trp Gly Leu Arg Leu Phe Gly Glu Phe Ser Val Trp Phe 100 105 110 Asp Pro Trp Gly Leu Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3607 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 364 LC variable region <400> 3607 Glu Leu Ala Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 3608 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 364 HC variable region <400> 3608 Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3609 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 365 LC variable region <400> 3609 Glu Leu Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 1 5 10 15 Thr Val Thr Leu Thr Cys Ser Ser Ser Thr Gly Ala Val Thr Arg Gly 20 25 30 His Phe Pro Asn Trp Leu Gln Gln Lys Pro Gly Gln Thr Pro Arg Ala 35 40 45 Leu Ile His Ser Thr Ser Asn Lys His Ser Trp Thr Pro Ala Arg Phe 50 55 60 Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Leu Ser Gly Val 65 70 75 80 Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Tyr Asp Ala Gly 85 90 95 Ala Pro Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3610 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 365 HC variable region <400> 3610 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Leu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Ser Cys Ser Gly Gly Ser Cys Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3611 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 366 LC variable region <400> 3611 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 65 70 75 80 Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 85 90 95 Ser Gly Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3612 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No. 366 HC variable region <400> 3612 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Gly Ile Ser Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Ala Thr Thr Lys Phe Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Thr Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Trp Gly Leu Arg Leu Phe Gly Glu Phe Ser Val Trp Phe 100 105 110 Asp Pro Trp Gly Leu Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3613 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No. 367 LC variable region <400> 3613 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Phe Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Ser Ser Leu 85 90 95 Ser Thr Pro Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3614 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 367 HC variable region <400> 3614 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Leu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Ser Cys Ser Gly Gly Ser Cys Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3615 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 368 LC variable region <400> 3615 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3616 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No. 368 HC variable region <400> 3616 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Arg Phe Ser Ser Asn 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Asn Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Met Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Ser Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Leu Ala Tyr Phe His Pro Gln Arg Asn Gly Gly Tyr Glu Tyr 100 105 110 Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Pro 115 120 125 <210> 3617 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 369 LC variable region <400> 3617 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Ala Ser Lys Asp Ala Ala Ser Ala Tyr Leu Thr Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 85 90 95 Leu Arg Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3618 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No. 369 HC variable region <400> 3618 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Gln 20 25 30 Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Tyr Gly Gly Ser Thr Thr Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Pro Ser Gly Tyr Tyr Gly Asp Tyr Glu Gly Asp Ala Phe 100 105 110 Asp Ile Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 3619 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 370 LC variable region <400> 3619 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3620 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> No. 370 HC variable region <400> 3620 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gin Gly Leu Glu Trp Val 35 40 45 Gly Arg Ile Ile Pro Ile Phe Gly Thr Val Lys Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Leu Pro Gly Asp Ser Arg Asp Gly Tyr Asn Tyr Asp Ala 100 105 110 Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Leu 115 120 125 <210> 3621 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 371 LC variable region <400> 3621 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3622 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No. 371 HC variable region <400> 3622 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3623 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 372 LC variable region <400> 3623 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3624 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No. 372 HC variable region <400> 3624 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 3625 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 373 LC variable region <400> 3625 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3626 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 373 HC variable region <400> 3626 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Ile Tyr Asn Trp Phe Asp Ser Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3627 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 374 LC variable region <400> 3627 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Arg Asn Trp Pro Pro 85 90 95 Val Leu Thr Phe Gly Gin Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3628 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 374 HC variable region <400> 3628 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Glu Gly Tyr Asp Ser Ser Gly Tyr Tyr Leu Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3629 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 375 LC variable region <400> 3629 Glu Leu Gly Gln Thr Gln Gln Leu Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3630 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 375 HC variable region <400> 3630 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asp Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ala Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Gly Leu Tyr Gly Ser Gly Trp Ser Thr Tyr Gln Tyr 100 105 110 Tyr Ala Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3631 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 376 LC variable region <400> 3631 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Arg Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3632 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 376 HC variable region <400> 3632 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3633 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 377 LC variable region <400> 3633 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3634 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 377 HC variable region <400> 3634 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3635 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 378 LC variable region <400> 3635 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Lys Tyr Thr Phe Gly Gin Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3636 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 378 HC variable region <400> 3636 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Glu Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Pro 115 120 <210> 3637 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> No. 379 LC variable region <400> 3637 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Trp Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3638 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 379 HC variable region <400> 3638 Glu Val Gln Leu Leu Glu Ser Gly Gly Ser Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Arg Gly Gly Ser Tyr Leu Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3639 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 380 LC variable region <400> 3639 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Arg Asn Trp Pro Pro 85 90 95 Arg Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3640 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 380 HC variable region <400> 3640 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Glu Gly Tyr Asp Ser Ser Gly Tyr Tyr Leu Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3641 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 381 LC variable region <400> 3641 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Ser 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3642 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 381 HC variable region <400> 3642 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3643 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 382 LC variable region <400> 3643 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Gly Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3644 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 382 HC variable region <400> 3644 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3645 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 383 LC variable region <400> 3645 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Lys Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3646 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 383 HC variable region <400> 3646 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Ser Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3647 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 384 LC variable region <400> 3647 Glu Leu Gln Met Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 3648 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 384 HC variable region <400> 3648 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3649 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 385 LC variable region <400> 3649 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3650 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 385 HC variable region <400> 3650 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Asp Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3651 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> No. 386 LC variable region <400> 3651 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Trp Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3652 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 386 HC variable region <400> 3652 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Glu Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3653 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> No. 387 LC variable region <400> 3653 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Trp Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3654 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 387 HC variable region <400> 3654 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Arg Gly Gly Ser Tyr Leu Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3655 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 388 LC variable region <400> 3655 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Asn Pro Phe 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3656 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 388 HC variable region <400> 3656 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Glu Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3657 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 389 LC variable region <400> 3657 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Met Tyr Thr Phe Gly Gin Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3658 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 389 HC variable region <400> 3658 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ile Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3659 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 390 LC variable region <400> 3659 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Arg Ser Asn Ile Gly Ile Asn 20 25 30 Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Leu Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Glu Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3660 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 390 HC variable region <400> 3660 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3661 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No. 391 LC variable region <400> 3661 Glu Leu Ala Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Ala Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Gly Asp Tyr Phe Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Gly Thr Leu Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3662 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 391 HC variable region <400> 3662 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3663 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 392 LC variable region <400> 3663 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn 20 25 30 Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Val Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Thr Ser Leu 85 90 95 Ser Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3664 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 392 HC variable region <400> 3664 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3665 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 393 LC variable region <400> 3665 Glu Leu Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Thr Tyr Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3666 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> No. 393 HC variable region <400> 3666 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Ala Ile Trp His Asp Gly Tyr Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Ser Lys Ala Ala Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Ile Val Ser Ser 115 <210> 3667 <211> 105 <212> PRT <213> Artificial Sequence <220> <223> No. 394 LC variable region <400> 3667 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 35 40 45 Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Phe 85 90 95 Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> 3668 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 394 HC variable region <400> 3668 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Gly Thr Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Val Ile Ser Tyr Asp Gly Phe Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Leu Gly Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3669 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 395 LC variable region <400> 3669 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Thr Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Met Tyr Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3670 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 395 HC variable region <400> 3670 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Glu Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3671 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 396 LC variable region <400> 3671 Glu Leu Ala Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Arg Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3672 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 396 HC variable region <400> 3672 Gln Ile Thr Leu Lys Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Gly Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Pro Ser Asp Leu Ser Phe Ile Trp Thr Gly Tyr Tyr Ser 100 105 110 Glu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3673 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 397 LC variable region <400> 3673 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3674 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 397 HC variable region <400> 3674 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Pro Arg Gly Tyr Ser Gly Tyr Gly Ser Asn Trp Tyr Phe Asp 100 105 110 Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3675 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 398 LC variable region <400> 3675 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe 20 25 30 Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Ala Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3676 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 398 HC variable region <400> 3676 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3677 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 399 LC variable region <400> 3677 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Thr Thr Gln Asn Ile Asn Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Thr Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Val Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Arg Ser Tyr Ser Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3678 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 399 HC variable region <400> 3678 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Pro Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 35 40 45 Ala Leu Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Thr Tyr Gly Ser Tyr Tyr Tyr Gly Met Asp Ala Trp Gly 100 105 110 Leu Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3679 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 400 LC variable region <400> 3679 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3680 <211> 115 <212> PRT <213> Artificial Sequence <220> <223> No. 400 HC variable region <400> 3680 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Tyr Ala Leu Asn Pro Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 3681 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 401 LC variable region <400> 3681 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3682 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 401 HC variable region <400> 3682 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3683 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 402 LC variable region <400> 3683 Glu Leu Val Val Thr Gln Pro Pro Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3684 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 402 HC variable region <400> 3684 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3685 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 403 LC variable region <400> 3685 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Ser Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3686 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 403 HC variable region <400> 3686 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3687 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 404 LC variable region <400> 3687 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3688 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 404 HC variable region <400> 3688 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3689 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 405 LC variable region <400> 3689 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3690 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 405 HC variable region <400> 3690 Glu Val Gln Leu Met Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3691 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 406 LC variable region <400> 3691 Glu Leu Val Met Thr Gln Ser Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 3692 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 406 HC variable region <400> 3692 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Ser Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3693 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 407 LC variable region <400> 3693 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3694 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 407 HC variable region <400> 3694 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Arg Tyr Tyr Asp Phe Trp Ser Gly Trp Asp Val Met Asp 100 105 110 Val Trp Gly Gin Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3695 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 408 LC variable region <400> 3695 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Ser Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3696 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 408 HC variable region <400> 3696 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3697 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 409 LC variable region <400> 3697 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Val Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Arg Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Thr Ser Leu 85 90 95 Ser Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3698 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 409 HC variable region <400> 3698 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Leu Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3699 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 410 LC variable region <400> 3699 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Gln Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3700 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 410 HC variable region <400> 3700 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Ile Ile Asn Arg Ser Gly Gly Ser Thr Ile Tyr Ala Gln Thr Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Met Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Arg His Ser Leu Asp Val Trp Gly Lys Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3701 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 411 LC variable region <400> 3701 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Arg Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3702 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No. 411 HC variable region <400> 3702 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Asp His Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 3703 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 412 LC variable region <400> 3703 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Thr Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3704 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 412 HC variable region <400> 3704 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Ser Ser Asn Trp Tyr Glu Ala Trp Thr Pro Arg Gly 100 105 110 Ile Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3705 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> No. 413 LC variable region <400> 3705 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Val Ser Pro Gly Gln 1 5 10 15 Thr Ala Arg Ile Thr Cys Ser Gly Asp Val Leu Ala Lys Lys Tyr Ala 20 25 30 Arg Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Ala Gln Val Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Tyr Ser Ala Ala Asp Asn Asn Gly Val 85 90 95 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> 3706 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No. 413 HC variable region <400> 3706 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asp 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ala Thr Tyr Asp Ser Ser Gly Arg Pro Thr Gly Asp Tyr 100 105 110 Gly Met Asp Val Trp Gly Gin Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3707 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 414 LC variable region <400> 3707 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Arg Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3708 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 414 HC variable region <400> 3708 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Gly Ser Gly Tyr Tyr Gln Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3709 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 415 LC variable region <400> 3709 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3710 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 415 HC variable region <400> 3710 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Arg Tyr Tyr Ser Ser Trp Tyr Gly Pro Arg Thr Trp Phe Asp 100 105 110 Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3711 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 416 LC variable region <400> 3711 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Arg Ser Asn Trp Pro Pro 85 90 95 Ala Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3712 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 416 HC variable region <400> 3712 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Ser Gly Tyr Asp Ser Ser Gly Tyr Tyr Ser Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3713 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 417 LC variable region <400> 3713 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 85 90 95 Ser Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3714 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 417 HC variable region <400> 3714 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr His Cys 85 90 95 Val Arg Val Gly Thr Tyr Asp Ser Ser Gly Tyr Ser Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3715 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 418 LC variable region <400> 3715 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3716 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 418 HC variable region <400> 3716 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 3717 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 419 LC variable region <400> 3717 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Asp Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Ala Pro Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3718 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 419 HC variable region <400> 3718 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Pro Arg Gly Gly Asn Tyr Arg Gly Ala Leu Asp Ile Trp Gly 100 105 110 Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 3719 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 420 LC variable region <400> 3719 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Val Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Pro 85 90 95 Ile Thr Phe Gly Gin Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3720 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 420 HC variable region <400> 3720 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ala Met Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Pro Thr Gly Trp Tyr Ser Gly Tyr Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3721 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 421 LC variable region <400> 3721 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 20 25 30 Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3722 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 421 HC variable region <400> 3722 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Met Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Asp Ser Ser Gly Tyr Tyr Pro Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3723 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 422 LC variable region <400> 3723 Glu Leu Lys Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3724 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 422 HC variable region <400> 3724 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 20 25 30 Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Asp Pro Glu Asp Ala Glu Thr Ile Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Ser Pro Ala Val Thr Thr Ala Gly Trp Phe Asp Pro Cys Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3725 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 423 LC variable region <400> 3725 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Asp 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Arg Gly Asp Ile Gly Ala Tyr 20 25 30 Asp Gly Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 35 40 45 Ile Ile Tyr Ala Val Thr Gln Arg Pro Ser Gly Ile Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3726 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 423 HC variable region <400> 3726 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Pro Glu Leu 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ile Ser Pro Ala Ile Ile Arg Val Asp Trp Phe Asp Pro Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3727 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 424 LC variable region <400> 3727 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Asp 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Arg Gly Asp Ile Gly Ala Tyr 20 25 30 Asp Gly Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 35 40 45 Ile Ile Tyr Ala Val Thr Gln Arg Pro Ser Gly Ile Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3728 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 424 HC variable region <400> 3728 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 3729 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 425 LC variable region <400> 3729 Glu Leu Ala Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Ser Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 3730 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 425 HC variable region <400> 3730 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3731 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 426 LC variable region <400> 3731 Glu Leu Ala Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Lys Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Pro Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 3732 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 426 HC variable region <400> 3732 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3733 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 427 LC variable region <400> 3733 Glu Leu Ala Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Asn Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3734 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 427 HC variable region <400> 3734 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Phe Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser His Lys Asn Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Asn Cys Gly Gly Asp Cys Gly Gly Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3735 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 428 LC variable region <400> 3735 Glu Leu Gln Met Thr Gln Ser Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Thr Asp Ile Gly Arg Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Tyr Ala Phe Gly Thr Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 3736 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> No. 428 HC variable region <400> 3736 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Pro Glu Val 20 25 30 Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Gly Pro Val Leu Gly Leu Ser Lys Trp Leu Glu Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3737 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 429 LC variable region <400> 3737 Glu Leu Gln Met Thr Gln Ser Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 3738 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> No. 429 HC variable region <400> 3738 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Pro Glu Val 20 25 30 Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Gly Pro Val Leu Gly Leu Ser Lys Trp Leu Glu Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3739 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 430 LC variable region <400> 3739 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3740 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 430 HC variable region <400> 3740 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 3741 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 431 LC variable region <400> 3741 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Glu Ala Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3742 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 431 HC variable region <400> 3742 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 3743 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 432 LC variable region <400> 3743 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Thr Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3744 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 432 HC variable region <400> 3744 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 3745 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 433 LC variable region <400> 3745 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3746 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 433 HC variable region <400> 3746 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 3747 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 434 LC variable region <400> 3747 Glu Leu Val Val Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3748 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 434 HC variable region <400> 3748 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Arg Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Arg Gly Gln Asp Tyr Gly Asp Tyr Gly Phe Leu Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 3749 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 435 LC variable region <400> 3749 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3750 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No. 435 HC variable region <400> 3750 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Tyr 20 25 30 Val Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Ile Pro Val Phe Gly Ile Ala Asp Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Gly Leu Phe Asp Trp Leu Leu Pro Arg Ser Arg His Arg 100 105 110 Asp Tyr Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3751 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 436 LC variable region <400> 3751 Glu Leu Gly Gln Thr Gln Gln Leu Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3752 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> No. 436 HC variable region <400> 3752 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Pro Thr Ser Arg Ser Thr Tyr Tyr Tyr Tyr Ser Gly Ser 100 105 110 Tyr Tyr Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3753 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 437 LC variable region <400> 3753 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Gly Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 3754 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> No. 437 HC variable region <400> 3754 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Met Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Pro Thr Ser Arg Ser Thr Tyr Tyr Tyr Tyr Ser Gly Ser 100 105 110 Tyr Tyr Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3755 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 438 LC variable region <400> 3755 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Arg Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3756 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No. 438 HC variable region <400> 3756 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 20 25 30 Pro Ile His Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Arg Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Asn Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Asp Leu Thr Thr Val Thr Asn Pro Leu Asn Tyr Tyr Tyr Tyr 100 105 110 Gly Met Asp Val Trp Gly Gin Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 3757 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 439 LC variable region <400> 3757 Glu Leu Glu Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Val Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Ser Gln Arg Pro Ser Gly Val Pro Ala Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Val Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Met Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3758 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No. 439 HC variable region <400> 3758 Gln Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Ser Tyr 20 25 30 Gly Thr Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Gly Tyr Asn Glu Asn Ser Thr His Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ala Leu Arg Tyr Asp Ile Leu Thr Gly Phe Thr Gly Phe 100 105 110 Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 115 120 125 <210> 3759 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 440 LC variable region <400> 3759 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3760 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 440 HC variable region <400> 3760 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Asp Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Lys Val Arg Tyr Tyr Asp Phe Trp Ser Gly Trp Asp Val Met Asp 100 105 110 Val Trp Gly Gin Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3761 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 441 LC variable region <400> 3761 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3762 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No. 441 HC variable region <400> 3762 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Thr Tyr Tyr Tyr Asp Ser Ser Gly Pro Leu Asn Trp Phe 100 105 110 Asp Pro Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3763 <211> 103 <212> PRT <213> Artificial Sequence <220> <223> No. 442 LC variable region <400> 3763 Glu Leu Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Ser Leu Ser Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Leu Thr Phe Gly Gly 85 90 95 Gly Thr Lys Val Glu Ile Lys 100 <210> 3764 <211> 126 <212> PRT <213> Artificial Sequence <220> <223> No. 442 HC variable region <400> 3764 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Phe Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Thr Gly Lys Pro Tyr Tyr Cys Thr Gly Ser Thr Cys Tyr Gln Pro 100 105 110 Leu Gly Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3765 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 443 LC variable region <400> 3765 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3766 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 443 HC variable region <400> 3766 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser Ser 20 25 30 Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Ile Ala Leu Asn Asn Tyr Tyr Gly Met Asp Val Trp Gly 100 105 110 Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 3767 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 444 LC variable region <400> 3767 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asn Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Asp Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Gly Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3768 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 444 HC variable region <400> 3768 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Pro Glu Leu 20 25 30 Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Asp Pro Glu Asn Gly Glu Thr Ile His Ala Gln Arg Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Ser Thr Pro Met Ile Arg Ala Ser Trp Phe Asp Pro Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3769 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 445 LC variable region <400> 3769 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Phe Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Gln Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3770 <211> 115 <212> PRT <213> Artificial Sequence <220> <223> No. 445 HC variable region <400> 3770 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Tyr Ser Gly Asn Phe Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 3771 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 446 LC variable region <400> 3771 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3772 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 446 HC variable region <400> 3772 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ile Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Thr Gly Tyr Asp Ser Ser Gly Tyr Tyr Gln Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3773 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 447 LC variable region <400> 3773 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Arg Asn 20 25 30 Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Thr Arg Ala Thr Asp Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3774 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 447 HC variable region <400> 3774 Gln Ile Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3775 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 448 LC variable region <400> 3775 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Thr Ser Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3776 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 448 HC variable region <400> 3776 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3777 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 449 LC variable region <400> 3777 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3778 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 449 HC variable region <400> 3778 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Gly 20 25 30 Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3779 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 450 LC variable region <400> 3779 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3780 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 450 HC variable region <400> 3780 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3781 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 451 LC variable region <400> 3781 Glu Leu Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Tyr 20 25 30 Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr His Thr Ser Pro Ile 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3782 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 451 HC variable region <400> 3782 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3783 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 452 LC variable region <400> 3783 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ile 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 3784 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 452 HC variable region <400> 3784 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 3785 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 453 LC variable region <400> 3785 Glu Leu Ala Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Val Gly Asp Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Thr Asn Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Gly 85 90 95 Ser Thr Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3786 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 453 HC variable region <400> 3786 Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3787 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 454 LC variable region <400> 3787 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3788 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 454 HC variable region <400> 3788 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3789 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 455 LC variable region <400> 3789 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3790 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 455 HC variable region <400> 3790 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3791 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 456 LC variable region <400> 3791 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Gln 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 3792 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 456 HC variable region <400> 3792 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3793 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 457 LC variable region <400> 3793 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Met 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 3794 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 457 HC variable region <400> 3794 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3795 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 458 LC variable region <400> 3795 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Gly Ser Ser Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3796 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 458 HC variable region <400> 3796 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 3797 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 459 LC variable region <400> 3797 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 3798 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No. 459 HC variable region <400> 3798 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 3799 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 460 LC variable region <400> 3799 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3800 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No. 460 HC variable region <400> 3800 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 3801 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 461 LC variable region <400> 3801 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Gly Val Thr Ile Ser Cys Ser Gly Leu Thr Ser Asn Ile Gly Ser Asn 20 25 30 Phe Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Gly Glu Tyr Phe Cys Ala Ala Trp Asp Asp Thr Leu 85 90 95 Val Gly Arg Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3802 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No. 461 HC variable region <400> 3802 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Pro Ser 130 <210> 3803 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No. 462 LC variable region <400> 3803 Glu Leu Val Val Thr Gln Glu Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Pro Val Phe Gly Gly Thr Gln Leu Thr Val Leu 100 105 <210> 3804 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 462 HC variable region <400> 3804 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Arg Gly Ser Gly Tyr Ser Phe Thr Ser His 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3805 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 463 LC variable region <400> 3805 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3806 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 463 HC variable region <400> 3806 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Arg Gly Ser Gly Tyr Ser Phe Thr Ser His 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3807 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 464 LC variable region <400> 3807 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Ser Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3808 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 464 HC variable region <400> 3808 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Ser Ser Gly Tyr Ser Phe Ile Ser Tyr 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Leu Tyr Asn Trp Phe Asp Phe Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3809 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 465 LC variable region <400> 3809 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly His Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 3810 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 465 HC variable region <400> 3810 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ile Ser Tyr 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Glu Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Leu Tyr Asn Trp Phe Asp Phe Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3811 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 466 LC variable region <400> 3811 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3812 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 466 HC variable region <400> 3812 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Arg Gly Ser Gly Tyr Ser Phe Thr Ser His 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ser Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Gly Pro Asn Leu Tyr Asn Trp Phe Asp Ser Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3813 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 467 LC variable region <400> 3813 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3814 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 467 HC variable region <400> 3814 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Tyr Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3815 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No. 468 LC variable region <400> 3815 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Ser 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu 35 40 45 Tyr Ala Ala Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 3816 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No. 468 HC variable region <400> 3816 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 20 25 30 Tyr Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Pro Asn Ser Gly Asp Thr Asn Tyr Ala His Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ser Tyr Tyr Asn Val Met Tyr Trp Phe Asp Pro Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3817 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 469 LC variable region <400> 3817 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Ser Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3818 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 469 HC variable region <400> 3818 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asn 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Thr Tyr Gly Ser Gly Ser Tyr Ser Asp Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3819 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 470 LC variable region <400> 3819 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3820 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 470 HC variable region <400> 3820 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asn 20 25 30 Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Thr Tyr Gly Ser Gly Ser Tyr Ser Asp Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3821 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 471 LC variable region <400> 3821 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Arg Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3822 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 471 HC variable region <400> 3822 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Asn Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Tyr Cys Gly Asp Asp Cys Tyr Pro Val Val Gly Thr Pro 100 105 110 Gly Asp Ala Phe Asp Ile Trp Gly Gly Gly Thr Met Val Thr Val Ser 115 120 125 Ser <210> 3823 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 472 LC variable region <400> 3823 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3824 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 472 HC variable region <400> 3824 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Ser Asn Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Tyr Cys Gly Asp Asp Cys Tyr Pro Val Val Gly Thr Pro 100 105 110 Gly Asp Ala Phe Asp Ile Trp Gly Gly Gly Thr Met Val Thr Val Ser 115 120 125 Ser <210> 3825 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 473 LC variable region <400> 3825 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Met Gln Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3826 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 473 HC variable region <400> 3826 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Asn Tyr 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Tyr Asp Ser Asp Thr Arg Lys Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Met Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Thr Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Gln Asp Ser Gly Thr Tyr Gly Trp Ile Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3827 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 474 LC variable region <400> 3827 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3828 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No. 474 HC variable region <400> 3828 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Phe Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 85 90 95 Cys Ala Arg Gln Glu Trp Leu Arg Gly Gly Phe Asp Asp Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 3829 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 475 LC variable region <400> 3829 Glu Leu Gln Met Thr Gln Ser Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Val Gly Ser Asn 20 25 30 Ile Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Ala Trp Val Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 3830 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No. 475 HC variable region <400> 3830 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 1 5 10 15 Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Asn His 20 25 30 Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Tyr Pro Tyr Asp Ser Asp Thr Lys Tyr Ser Pro Ser Phe 50 55 60 Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Val Ser Thr Ala Tyr 65 70 75 80 Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Asn Pro Thr Val Thr Asn Trp Phe Asp Ser Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 3831 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> No. 476 LC variable region <400> 3831 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Pro Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val 100 105 110 Leu <210> 3832 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No. 476 HC variable region <400> 3832 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Phe Phe Gly Thr Ser Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Val Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gln Phe Ser Asp Ser Ser Gly Tyr Gln His Pro Tyr Tyr 100 105 110 Asp Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser 115 120 125 Ser <210> 3833 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 477 LC variable region <400> 3833 Glu Leu Ala Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3834 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No. 477 HC variable region <400> 3834 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr His 20 25 30 Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Pro Ala Asp Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Leu Ser Leu Gly Phe Cys Ser Ala Gly Ser Cys Tyr Asp 100 105 110 Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 3835 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No. 478 LC variable region <400> 3835 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asp Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 3836 <211> 133 <212> PRT <213> Artificial Sequence <220> <223> No. 478 HC variable region <400> 3836 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 20 25 30 Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Tyr Pro Gly Tyr Tyr Asp Ile Leu Thr Gly Gln Ile 100 105 110 Gly Thr Gly Glu Arg Asn Ala Met Asp Val Trp Gly Gin Gly Thr Thr 115 120 125 Val Thr Val Ser Ser 130 <210> 3837 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No. 479 LC variable region <400> 3837 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 3838 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No. 479 HC variable region <400> 3838 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Ser Asn Tyr 20 25 30 Pro Leu Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Gly Ile Ile Pro Ile Ile Gly Ala Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Phe 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Arg Gly Tyr Ser Gly Tyr Gly Ala Ala Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 3839 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No. 480 LC variable region <400> 3839 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 85 90 95 Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 3840 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> No. 480 HC variable region <400> 3840 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Phe Ile Asn Pro Ser Asp Val Thr Thr Tyr Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Arg Ser Arg Ile Ala Pro Thr Glu Asp Phe Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Ser Leu Val Thr Val Ser Ser 115 120 <210> 3841 <211> 1273 <212> PRT <213> Artificial Sequence <220> <223> SARS-CoV-2 virus spike protein sequence <400> 3841 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 1010 1015 1020 Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 1025 1030 1035 1040 Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 1045 1050 1055 Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 1060 1065 1070 Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 1075 1080 1085 Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 1090 1095 1100 Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 1105 1110 1115 1120 Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 1125 1130 1135 Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 1140 1145 1150 Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 1155 1160 1165 Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 1170 1175 1180 Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 1185 1190 1195 1200 Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 1205 1210 1215 Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 1220 1225 1230 Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 1235 1240 1245 Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 1250 1255 1260 Leu Lys Gly Val Lys Leu His Tyr Thr 1265 1270 <210> 3842 <211> 1273 <212> PRT <213> Artificial Sequence <220> <223> SARS-CoV-2 virus spike protein RBD sequence <400> 1 Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 1 5 10 15 Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 20 25 30 Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 35 40 45 Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 50 55 60 Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 65 70 75 80 Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 85 90 95 Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 100 105 110 Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 115 120 125 Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 130 135 140 Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 145 150 155 160 Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 165 170 175 Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 180 185 190 Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 195 200 205 Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 210 215 220

Claims (30)

(A) 사스-코로나바이러스-2(SARS-CoV-2) 표면의 스파이크 단백질(Spike protein, S protein)에 결합하는 중화 결합 분자;
(B) 완충제;
(C) 안정화제; 및
(D) 계면활성제를 포함하는, 안정한 약제학적 제제.(A) a neutralizing binding molecule that binds to a spike protein (S protein) on the surface of SARS-CoV-2;
(B) a buffer;
(C) stabilizers; and
(D) A stable pharmaceutical formulation comprising a surfactant. 제1항에 있어서, 상기 약제학적 제제는 액상임을 특징으로 하는, 안정한 약제학적 제제.The stable pharmaceutical formulation according to claim 1, characterized in that the pharmaceutical formulation is liquid. 제1항에 있어서,
(A) 중화 결합 분자는 사스-코로나바이러스-2 표면의 스파이크 단백질의 RBD(Receptor binding domain) 영역에 결합함을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(A) A stable pharmaceutical formulation, characterized in that the neutralizing binding molecule binds to the receptor binding domain (RBD) region of the spike protein on the surface of SARS-coronavirus-2. 제1항에 있어서,
(A) 중화 결합 분자는 표 1 또는 표 3의 결합 분자로 이루어진 군으로부터 선택되는 어느 하나임을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(A) A stable pharmaceutical formulation, characterized in that the neutralizing binding molecule is any one selected from the group consisting of the binding molecules of Table 1 or Table 3. 제1항에 있어서,
(A) 중화 결합 분자는 표 2 또는 표 4의 결합 분자로 이루어진 군으로부터 선택되는 어느 하나임을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(A) A stable pharmaceutical formulation, characterized in that the neutralizing binding molecule is any one selected from the group consisting of the binding molecules of Table 2 or Table 4. 제1항 내지 제5항 중 어느 한 항에 있어서,
(A) 중화 결합 분자는 scFv 절편, scFv-Fc 절편, Fab 절편, Fv 절편, 디아바디(diabody), 키메라 항체, 인간화 항체 또는 인간 항체임을 특징으로 하는, 안정한 약제학적 제제.6. The method according to any one of claims 1 to 5,
(A) A stable pharmaceutical formulation, characterized in that the neutralizing binding molecule is an scFv fragment, scFv-Fc fragment, Fab fragment, Fv fragment, diabody, chimeric antibody, humanized antibody or human antibody. 제1항에 있어서,
(A) 중화 결합 분자는 서열번호: 829의 CDR1 영역, 서열번호: 830의 CDR2 영역, 및 서열번호: 831의 CDR3 영역을 포함하는 경쇄 가변영역; 및
서열번호: 832의 CDR1 영역, 서열번호: 833의 CDR2 영역, 및 서열번호: 834의 CDR3 영역을 포함하는 중쇄 가변영역
을 포함함을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(A) a neutralizing binding molecule comprising: a light chain variable region comprising a CDR1 region of SEQ ID NO: 829, a CDR2 region of SEQ ID NO: 830, and a CDR3 region of SEQ ID NO: 831; and
a heavy chain variable region comprising the CDR1 region of SEQ ID NO: 832, the CDR2 region of SEQ ID NO: 833, and the CDR3 region of SEQ ID NO: 834
A stable pharmaceutical formulation comprising a. 제1항에 있어서,
(A) 중화 결합 분자는 서열번호: 2017의 폴리펩티드 서열의 경쇄 가변영역; 및
서열번호: 2018의 폴리펩티드 서열의 중쇄 가변영역
을 포함하는 결합 분자와 80% 내지 99% 동일한 서열을 포함함을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(A) the neutralizing binding molecule comprises a light chain variable region of the polypeptide sequence of SEQ ID NO: 2017; and
SEQ ID NO: 2018 heavy chain variable region of the polypeptide sequence
A stable pharmaceutical formulation, characterized in that it contains a sequence that is 80% to 99% identical to a binding molecule comprising a. 제1항에 있어서,
(A) 중화 결합 분자는 서열번호: 2017의 폴리펩티드 서열의 경쇄 가변영역; 및
서열번호: 2018의 폴리펩티드 서열의 중쇄 가변영역
을 포함함을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(A) the neutralizing binding molecule comprises a light chain variable region of the polypeptide sequence of SEQ ID NO: 2017; and
SEQ ID NO: 2018 heavy chain variable region of the polypeptide sequence
A stable pharmaceutical formulation comprising a. 제1항에 있어서,
(A) 중화 결합 분자는 서열번호: 2507의 CDR1 영역, 서열번호: 2508의 CDR2 영역, 및 서열번호: 2509의 CDR3 영역을 포함하는 경쇄 가변영역; 및
서열번호: 2510의 CDR1 영역, 서열번호: 2511의 CDR2 영역, 및 서열번호: 2512의 CDR3 영역을 포함하는 중쇄 가변영역
을 포함함을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(A) a neutralizing binding molecule comprises a light chain variable region comprising a CDR1 region of SEQ ID NO: 2507, a CDR2 region of SEQ ID NO: 2508, and a CDR3 region of SEQ ID NO: 2509; and
a heavy chain variable region comprising the CDR1 region of SEQ ID NO: 2510, the CDR2 region of SEQ ID NO: 2511, and the CDR3 region of SEQ ID NO: 2512
A stable pharmaceutical formulation comprising a. 제1항에 있어서,
(A) 중화 결합 분자는 서열번호: 3523의 폴리펩티드 서열의 경쇄 가변영역; 및
서열번호: 3524의 폴리펩티드 서열의 중쇄 가변영역
을 포함하는 결합 분자와 80% 내지 99% 동일한 서열을 포함함을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(A) the neutralizing binding molecule comprises a light chain variable region of the polypeptide sequence of SEQ ID NO: 3523; and
Heavy chain variable region of the polypeptide sequence of SEQ ID NO: 3524
A stable pharmaceutical formulation, characterized in that it contains a sequence that is 80% to 99% identical to a binding molecule comprising a. 제1항에 있어서,
(A) 중화 결합 분자는 서열번호: 3523의 폴리펩티드 서열의 경쇄 가변영역; 및
서열번호: 3524의 폴리펩티드 서열의 중쇄 가변영역
을 포함함을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(A) the neutralizing binding molecule comprises a light chain variable region of the polypeptide sequence of SEQ ID NO: 3523; and
Heavy chain variable region of the polypeptide sequence of SEQ ID NO: 3524
A stable pharmaceutical formulation comprising a. 제1항에 있어서,
(A) 중화 결합 분자의 농도는 1 내지 240 mg/ml임을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(A) A stable pharmaceutical formulation, characterized in that the concentration of the neutralizing binding molecule is 1 to 240 mg/ml. 제1항에 있어서,
(B) 완충제는i) 히스티딘, 히스티딘염 또는 이들의 혼합물, ii) 아세테이트(acetate), iii) 시트레이트(citrate), iv) 숙시네이트(succinate), v) 포스페이트(phosphate), 또는 vi) 글루코네이트(gluconate)를 포함함을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(B) the buffer is i) histidine, histidine salt or mixtures thereof, ii) acetate, iii) citrate, iv) succinate, v) phosphate, or vi) gluco A stable pharmaceutical preparation, characterized in that it contains gluconate. 제1항에 있어서,
(B) 완충제의 함량은 1 내지 100 mM임을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(B) A stable pharmaceutical formulation, characterized in that the content of the buffer is 1 to 100 mM. 제1항에 있어서,
(C) 안정화제는 i) 금속염, ii) 당 또는 이의 유도체 및 iii) 아미노산 또는 이의 염으로 구성된 군으로부터 선택되는 어느 하나 이상을 포함함을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(C) The stabilizing agent, characterized in that it comprises any one or more selected from the group consisting of i) a metal salt, ii) a sugar or a derivative thereof, and iii) an amino acid or a salt thereof. 제16항에 있어서,
상기 i) 금속염은 염화나트륨(NaCl), 염화칼륨(KCl), 염화칼슘(CaCl) 또는 이들 중 2 이상의 혼합물을 포함함을 특징으로 하는 안정한 약제학적 제제.17. The method of claim 16,
wherein i) the metal salt is sodium chloride (NaCl), potassium chloride (KCl), calcium chloride (CaCl), or a mixture of two or more thereof. 제16항에 있어서,
상기 ii) 당 또는 이의 유도체는 소르비톨, 만니톨, 트레할로스, 수크로오스 또는 이들 중 2 이상의 혼합물을 포함함을 특징으로 하는 안정한 약제학적 제제.17. The method of claim 16,
wherein ii) the sugar or derivative thereof comprises sorbitol, mannitol, trehalose, sucrose, or a mixture of two or more thereof. 제16항에 있어서,
상기 iii) 아미노산은 글리신, 트레오닌, 메티오닌, 아르기닌 또는 이들 중 2 이상의 혼합물을 포함함을 특징으로 하는, 안정한 약제학적 제제.17. The method of claim 16,
wherein iii) amino acid comprises glycine, threonine, methionine, arginine or a mixture of two or more thereof. 제14항에 있어서,
상기 iii) 아미노산의 염은 L-아르기닌 모노하이드로클로라이드(monohydrochloride)를 포함함을 특징으로 하는, 안정한 약제학적 제제.15. The method of claim 14,
The iii) salt of the amino acid is L- arginine monohydrochloride (monohydrochloride), characterized in that it comprises a stable pharmaceutical formulation. 제1항에 있어서,
(C) 안정화제의 함량은 50 내지 300 mM 또는 1 내지 20%(w/v)임을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(C) A stable pharmaceutical formulation, characterized in that the content of the stabilizer is 50 to 300 mM or 1 to 20% (w/v). 제1항에 있어서,
(D) 계면활성제는 폴리소르베이트, 폴록사머 또는 이들의 혼합물을 포함함을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(D) A stable pharmaceutical formulation, characterized in that the surfactant comprises a polysorbate, a poloxamer or a mixture thereof. 제21항에 있어서,
상기 폴리소르베이트는 폴리소르베이트 20, 폴리소르베이트 40, 폴리소르베이트 60, 폴리소르베이트 80 또는 이들의 혼합물을 포함함을 특징으로 하는, 안정한 약제학적 제제.22. The method of claim 21,
Wherein the polysorbate comprises polysorbate 20, polysorbate 40, polysorbate 60, polysorbate 80 or a mixture thereof, a stable pharmaceutical formulation. 제1항에 있어서,
(D) 계면활성제의 농도는 0.01 내지 0.1 %(w/v)임을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
(D) A stable pharmaceutical formulation, characterized in that the concentration of the surfactant is 0.01 to 0.1% (w/v). 제1항에 있어서,
pH가 5.0 내지 7.0임을 특징으로 하는, 안정한 약제학적 제제.According to claim 1,
A stable pharmaceutical formulation, characterized in that the pH is 5.0 to 7.0. (A) 사스-코로나바이러스-2(SARS-CoV-2) 표면의 스파이크 단백질(Spike protein, S protein)에 결합하는 중화 결합 분자 1 내지 240 mg/ml;
(B) 완충제 1 내지 100 mM;
(C) 안정화제 50 내지 300 mM 또는 1 내지 20%(w/v); 및
(D) 계면활성제 0.01 내지 0.1 %(w/v)를 포함하는, 안정한 약제학적 제제.(A) 1 to 240 mg/ml of a neutralizing binding molecule that binds to a spike protein (S protein) on the surface of SARS-CoV-2;
(B) Buffer 1-100 mM;
(C) 50 to 300 mM or 1 to 20% (w/v) of a stabilizing agent; and
(D) a stable pharmaceutical formulation comprising 0.01 to 0.1% (w/v) of a surfactant. 제26항에 있어서,
상기 (A) 중화 결합 분자는 서열번호: 829의 CDR1 영역, 서열번호: 830의 CDR2 영역, 및 서열번호: 831의 CDR3 영역을 포함하는 경쇄 가변영역; 및
서열번호: 832의 CDR1 영역, 서열번호: 833의 CDR2 영역, 및 서열번호: 834의 CDR3 영역을 포함하는 중쇄 가변영역
을 포함함을 특징으로 하는, 안정한 약제학적 제제.27. The method of claim 26,
Said (A) neutralizing binding molecule comprises: a light chain variable region comprising a CDR1 region of SEQ ID NO: 829, a CDR2 region of SEQ ID NO: 830, and a CDR3 region of SEQ ID NO: 831; and
a heavy chain variable region comprising the CDR1 region of SEQ ID NO: 832, the CDR2 region of SEQ ID NO: 833, and the CDR3 region of SEQ ID NO: 834
A stable pharmaceutical formulation comprising a. 제26항에 있어서,
상기 (A) 중화 결합 분자는 서열번호: 2507의 CDR1 영역, 서열번호: 2508의 CDR2 영역, 및 서열번호: 2509의 CDR3 영역을 포함하는 경쇄 가변영역; 및
서열번호: 2510의 CDR1 영역, 서열번호: 2511의 CDR2 영역, 및 서열번호: 2512의 CDR3 영역을 포함하는 중쇄 가변영역
을 포함함을 특징으로 하는, 안정한 약제학적 제제.27. The method of claim 26,
The (A) neutralizing binding molecule comprises: a light chain variable region comprising a CDR1 region of SEQ ID NO: 2507, a CDR2 region of SEQ ID NO: 2508, and a CDR3 region of SEQ ID NO: 2509; and
a heavy chain variable region comprising the CDR1 region of SEQ ID NO: 2510, the CDR2 region of SEQ ID NO: 2511, and the CDR3 region of SEQ ID NO: 2512
A stable pharmaceutical formulation comprising a. 제1항 내지 제28항 중 어느 한 항에 기재된 안정한 약제학적 제제가 충진된 유리 바이알(vial).29. A glass vial filled with the stable pharmaceutical formulation according to any one of claims 1 to 28. 제1항 내지 제28항 중 어느 한 항에 기재된 안정한 약제학적 제제가 충진된 프리-필드 시린지(pre-filled syringe).29. A pre-filled syringe filled with the stable pharmaceutical formulation according to any one of claims 1 to 28.
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