KR20220012826A - SARS-CoV-2 NEUTRALIZING BINDING MOLECULE BINDING TO EPITOPES OF SARS-CoV-2 SPIKE PROTEIN - Google Patents

SARS-CoV-2 NEUTRALIZING BINDING MOLECULE BINDING TO EPITOPES OF SARS-CoV-2 SPIKE PROTEIN Download PDF

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KR20220012826A
KR20220012826A KR1020210096237A KR20210096237A KR20220012826A KR 20220012826 A KR20220012826 A KR 20220012826A KR 1020210096237 A KR1020210096237 A KR 1020210096237A KR 20210096237 A KR20210096237 A KR 20210096237A KR 20220012826 A KR20220012826 A KR 20220012826A
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mutation
sars
coronavirus
amino acid
spike protein
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배진수
이지헌
김민수
김철민
서지민
심은영
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(주)셀트리온
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Abstract

The present invention relates to a SARS-coronavirus-2 neutralizing binding molecule binding to an epitope of a SARS-coronavirus-2 spike protein. The binding molecule of the present invention specifically binds to a specific epitope in the RBD of a spike protein on a SARS-coronavirus-2 surface, has an excellent binding ability, and has an excellent neutralizing effect on SARS-coronavirus-2, thereby being very useful for diagnosing, preventing, or treating SARS-coronavirus infection (COVID-19).

Description

사스-코로나바이러스-2 스파이크 단백질의 에피토프에 결합하는 사스-코로나바이러스-2 중화 결합 분자{SARS-CoV-2 NEUTRALIZING BINDING MOLECULE BINDING TO EPITOPES OF SARS-CoV-2 SPIKE PROTEIN}SARS-coronavirus-2 neutralizing binding molecule that binds to an epitope of the SARS-coronavirus-2 spike protein {SARS-CoV-2 NEUTRALIZING BINDING MOLECULE BINDING TO EPITOPES OF SARS-CoV-2 SPIKE PROTEIN}

본 발명은 사스-코로나바이러스-2 스파이크 단백질의 에피토프에 결합하는 사스-코로나바이러스-2 중화 결합 분자에 관한 것이다. The present invention relates to a SARS-coronavirus-2 neutralizing binding molecule that binds to an epitope of the SARS-coronavirus-2 spike protein.

사스-코로나바이러스-2(severe acute respiratory syndrome coronavirus 2, SARS-CoV-2)는 유전적 배열(DNA sequencing)상 전도 기능(Positive sense) 단일 가닥 RNA(single-stranded RNA) 코로나바이러스이다. SARS-CoV-2는 인간에게 전염성이 있고 코로나바이러스감염증-19(coronavirus disease 2019, COVID-19)의 원인이다. COVID-19의 최초 발생지는 중국 후베이성의 우한시이다. SARS-coronavirus-2 (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) is a positive sense single-stranded RNA coronavirus based on DNA sequencing. SARS-CoV-2 is contagious to humans and is the cause of coronavirus disease 2019 (COVID-19). The first outbreak of COVID-19 was in Wuhan, Hubei Province, China.

SARS-CoV-2에 감염된 사람들은 열, 기침, 호흡 곤란, 설사 등과 같이 경증 내지 중증의 증상을 보일 수 있다. 합병증이나 병을 가진 사람들, 노인은 사망할 가능성이 크다. People infected with SARS-CoV-2 may have mild to severe symptoms such as fever, cough, shortness of breath, and diarrhea. People with complications or diseases and the elderly are more likely to die.

특히 심장질환 및 당뇨병 등의 기저질환 보유자가 감염에 더 취약하며, 합병증이나 장기 손상 등을 겪기 때문에 조기 발견과 치료가 매우 중요하다. 2019년 12월 8일부터 2020년 3월 20일 현재까지 245,550명의 환자가 발생하였고, 그 중 10,049명이 사망하여 치사율은 4.09%에 달한다(WHO). 현재까지 한국을 포함한 177개국에서 발생하였다. In particular, people with underlying diseases such as heart disease and diabetes are more susceptible to infection and suffer complications or organ damage, so early detection and treatment are very important. From December 8, 2019 to March 20, 2020, there were 245,550 cases, of which 10,049 died, resulting in a fatality rate of 4.09% (WHO). So far, it has occurred in 177 countries, including Korea.

현재 코로나바이러스감염증-19(coronavirus disease 2019, COVID-19)의 치료제는 없고, 기존 치료제를 환자에게 투여하여 치료 효과를 기대하고 있는 실정이다. 에볼라 치료제 혹은 치료 후보 물질인 항바이러스제 파비피라비르 (favipiravir), 렘데시비르 (remdesivir), 갈리데시비어 (galidesivir)와 C형 간염 치료제인 리바비린 (ribavirin) 등을 COVID-19 치료제로 사용하고 있다. 또한, 말라리아치료제 클로로퀸 (Chloroquine)도 COVID-19에 치료 효과를 보이는 것으로 나타나 공개 임상시험 진행 중에 있다. 그러나 C형 간염 치료제인 리바비린은 빈혈과 같은 부작용이 심할 수 있고, 항바이러스제인 인터페론 (interferon)도 여러 가지 부작용을 우려하여 주의해서 사용할 것을 권고하고 있다. Currently, there is no treatment for coronavirus disease 2019 (COVID-19), and the existing treatment is administered to the patient to expect a therapeutic effect. Antiviral agents favipiravir, remdesivir, and galidesivir, which are Ebola treatment or treatment candidates, and hepatitis C treatment ribavirin are being used as COVID-19 treatments. In addition, the antimalarial drug Chloroquine has been shown to have a therapeutic effect on COVID-19 and is undergoing public clinical trials. However, hepatitis C treatment ribavirin may have severe side effects such as anemia, and the antiviral drug interferon is also recommended to be used with caution due to concerns about various side effects.

비록 이러한 약물들이 COVID-19 환자 치료에 활용되어 치료 효과를 보고 있지만, 아직 어떠한 근거로 치료 효과를 내는지는 아직 명확히 입증되지 않았다. 중국에서 COVID-19 회복 환자의 현장을 주입하는 혈장 요법을 시행하여 중증 환자의 치료에 효과를 보였다고 발표하였으나, 치료 효과가 불분명하고 불확실성이 크다. Although these drugs have been used to treat COVID-19 patients and are seeing therapeutic effects, it has not yet been clearly demonstrated on what basis they have therapeutic effects. In China, it was announced that the on-site injection of plasma therapy for patients recovering from COVID-19 was effective in the treatment of severely ill patients, but the therapeutic effect is unclear and there is great uncertainty.

한국의 경우, COVID-19 중앙임상 테스크포스(TF)가 2020년 2월 13일 COVID-19의 치료 원칙을 마련하여, 1차 치료제로 에이즈 치료제인 칼레트라 (Kaletra), 말라리아치료제인 클로로퀸과 하이드록시클로로퀸(Hydroxychloroquine)을 권하며, 리바비린과 인터페론은 부작용을 우려해 1차 치료제로 권하지 않기로 발표했다. 경증이거나 젊은 환자, 발병 10일이 지난 경우에는 항바이러스제를 투여하지 않아도 증상이 호전된다고 판단하고, 고령자, 기저질환자, 중증 환자에게는 항바이러스 치료제를 투여하기로 합의했다. In Korea, the COVID-19 Central Clinical Task Force (TF) prepared the treatment principle for COVID-19 on February 13, 2020, and as the first-line treatment, AIDS treatment Kaletra, malaria treatment chloroquine and hydroxy Chloroquine (Hydroxychloroquine) is recommended, and ribavirin and interferon are not recommended as first-line treatment due to concerns about side effects. In mild or young patients, if 10 days have passed since the onset of the disease, it was judged that the symptoms improved even if antiviral drugs were not administered.

미국 CDC는 i) COVID-19가 계절성 유행 바이러스가 아닌 메르스처럼 토착화되어 감염을 일으킬 수 있다고 발표하였고, ii) 바이러스가 올해 또는 내년 어느 시점에 커뮤니티로 전파될 수 있으며, 비록 코로나 바이러스가 실제 커뮤니티에 잠복되어 있다는 증거는 없으나, 데이터 기반으로 결론을 내릴 수 있도록 감시강화의 필요성을 언급하였다(2020.2.13).The U.S. CDC has announced that i) COVID-19 can become indigenous and cause infections like MERS rather than a seasonal virus, and ii) the virus may spread to communities at some point this year or next year, even though the coronavirus is Although there is no evidence that it is hidden in the

한국 질병관리본부(현, 질병관리청)는 i) COVID-19도 인플루엔자처럼 장기적으로 유행할 수 있다고 판단하여, 인플루엔자와 같이 감시 체계에 포함하겠다고 발표하였고, ii) 사람 사이에 유행하는 코로나바이러스(4종)도 겨울~봄에 유행하고 있어서 COVID-19도 토착화될 수 있다는 가능성을 열어두고 있다(2020.2.17).The Korea Centers for Disease Control and Prevention (currently, the Korea Centers for Disease Control and Prevention) announced that i) that COVID-19 could also spread like influenza for a long time and that it would be included in the surveillance system like influenza, and ii) a coronavirus that spreads among people (4 species) is also prevalent in winter and spring, leaving open the possibility that COVID-19 may also become indigenous (2020.2.17).

사스나 메르스와는 다르게 COVID-19의 세계적 유행 (pandemic) 현실화에 대한 우려가 있지만 봄 이후 (4월) 소강 상태가 될 가능성도 있어, 추이를 보며 신중하게 접근하는 전문가들이 많다. 아직 COVID-19에 대한 정보 부족으로 전문가들도 추후 전개 양상에 대해서는 의견이 분분하나, 단시일 내에 해결되리라 전망하는 전문가는 거의 없다. COVID-19의 유행 양상과 특징이 정확히 분석되고 이번 COVID-19로 인한 위기 상황이 얼마나 지속되는지에 영향을 받겠지만, 무증상 감염자가 전세계에 퍼지게 될 경우 풍토병화 될 가능성에 대한 우려가 있다. 중국 및 국내에서의 토착화를 통한 국내 COVID-19 재발병 가능성에 대한 대응책 마련이 시급하다. Unlike SARS and MERS, there are concerns about the realization of a global pandemic of COVID-19, but there is a possibility that there may be a lull after spring (April). Due to the lack of information on COVID-19, experts also have differing opinions about the future development, but few experts predict that it will be resolved in a short time. Although the pattern and characteristics of the COVID-19 epidemic will be accurately analyzed and will be affected by how long the crisis caused by this COVID-19 will last, there are concerns about the possibility that asymptomatic infections may become endemic if they spread around the world. It is urgent to prepare countermeasures against the possibility of a recurrence of COVID-19 in China and Korea through indigenization.

신속진단검사(Rapid diagnostic test, RDT)는 면역크로마토그래피 분석, 래피드 키트 분석 등 다양한 명칭으로 불린다. 사용자는 신속진단검사로 생물학적 또는 화학적 샘플로부터 분석 물질을 간단하게 검출할 수 있다. 신속진단검사는 생물학적 물질 또는 화학적 물질이 서로 특이적으로 부착하는 성질을 이용하여 분석 물질을 단시간에 정성 및 정량적으로 검사할 수 있는 방법이다. Rapid diagnostic test (RDT) is called by various names such as immunochromatographic analysis and rapid kit analysis. Users can simply detect analytes from biological or chemical samples with rapid diagnostic testing. The rapid diagnostic test is a method that can qualitatively and quantitatively test an analyte in a short time by using the property that biological or chemical substances specifically adhere to each other.

신속진단검사는 간편성 및 신속성 측면에서 최근까지 개발된 검출 방법 중 가장 진보된 분석 키트 중 하나로서 감염성 병원체의 항원 또는 항체, 암 인자, 심장병 마커 등 다양한 질병의 원인 물질을 진단하는데 유용하게 사용한다. The rapid diagnostic test is one of the most advanced analysis kits among detection methods developed recently in terms of simplicity and speed, and is usefully used to diagnose causative agents of various diseases, such as antigens or antibodies of infectious pathogens, cancer factors, and markers of heart disease.

SARS-CoV-2는 아직까지 이 바이러스에 특이적인 예방제 또는 치료제가 없다. 이에 따라, 본 발명자들은 SARS-CoV-2에 특이적인 항체를 개발하고자 하였다. 결합력, 중화능 및/또는 진단 효과가 우수한 항체를 개발하기 위해 지속적인 연구를 거듭한 결과, 본 발명을 완성하였다.SARS-CoV-2 does not yet have a specific prophylactic or therapeutic agent for this virus. Accordingly, the present inventors attempted to develop an antibody specific for SARS-CoV-2. As a result of repeated research to develop an antibody having excellent binding force, neutralizing ability and/or diagnostic effect, the present invention has been completed.

본 발명자들은 상기 문제점을 해결하고자 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질(S 단백질, Spike protein, S protein)에 대한 결합 능력을 갖는 결합 분자를 개발하였다. 본 발명자들은 상기 결합 분자가 SARS-CoV-2 S 단백질의 RBD 상의 특정 에피토프에 특이적으로 결합함을 규명하였고, SARS-CoV-2에 대하여 우수한 결합력 및/또는 중화 효력을 가짐을 확인함으로써 본 발명을 완성하였다. In order to solve the above problems, the present inventors have developed a binding molecule having a binding ability to the spike protein (S protein, Spike protein, S protein) of SARS-coronavirus-2 (SARS-CoV-2). The present inventors have identified that the binding molecule specifically binds to a specific epitope on the RBD of the SARS-CoV-2 S protein. was completed.

본 발명이 해결하고자 하는 과제는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질(Spike protein, S protein)의 RBD(Receptor Binding Domain) 내 특정 에피토프에 결합하는 사스-코로나바이러스-2 중화 결합 분자를 제공하는 것이다. The problem to be solved by the present invention is that SARS-coronavirus-2 binds to a specific epitope in the Receptor Binding Domain (RBD) of the spike protein (S protein) of SARS-CoV-2 to provide a neutralizing binding molecule.

또한, 본 발명이 해결하고자 하는 다른 과제는 본 발명에 따른 결합 분자에 추가적으로 하나 이상의 태그가 결합된 이뮤노컨쥬게이트를 제공하는 것이다. In addition, another object to be solved by the present invention is to provide an immunoconjugate in which one or more tags are additionally bound to the binding molecule according to the present invention.

또한, 본 발명이 해결하고자 하는 다른 과제는 본 발명에 따른 결합 분자를 암호화하는 핵산 분자를 제공하는 것이다. Another object to be solved by the present invention is to provide a nucleic acid molecule encoding the binding molecule according to the present invention.

또한, 본 발명이 해결하고자 하는 다른 과제는 본 발명에 따른 핵산 분자가 삽입된 발현 벡터를 제공하는 것이다. Another object to be solved by the present invention is to provide an expression vector into which a nucleic acid molecule according to the present invention is inserted.

또한, 본 발명이 해결하고자 하는 다른 과제는 본 발명에 따른 발현 벡터로 형질전환된 세포주를 제공하는 것이다. In addition, another object to be solved by the present invention is to provide a cell line transformed with the expression vector according to the present invention.

또한, 본 발명이 해결하고자 하는 다른 과제는 본 발명에 따른 결합 분자를 포함하는 사스-코로나바이러스 감염증(COVID-19)의 진단, 예방 또는 치료용 조성물을 제공하는 것이다. In addition, another object to be solved by the present invention is to provide a composition for diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19) comprising the binding molecule according to the present invention.

또한, 본 발명이 해결하고자 하는 다른 과제는 본 발명에 따른 결합 분자를 포함하는 사스-코로나바이러스 감염증(COVID-19) 진단, 예방 또는 치료용 키트를 제공하는 것이다.In addition, another object to be solved by the present invention is to provide a kit for diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19) comprising the binding molecule according to the present invention.

또한, 본 발명이 해결하고자 하는 다른 과제는 사스-코로나바이러스 감염증(COVID-19)으로 인하여 발생하는 질환을 가진 대상에 본 발명에 따른 조성물을 치료학적으로 유효한 양으로 투여하는 단계를 포함하는, 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료 방법을 제공하는 것이다. In addition, another problem to be solved by the present invention is SARS - including the step of administering a composition according to the present invention in a therapeutically effective amount to a subject having a disease caused by coronavirus infection (COVID-19), SARS -To provide a method for diagnosing, preventing or treating diseases caused by coronavirus infection.

또한, 본 발명이 해결하고자 하는 다른 과제는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질(Spike protein, S protein)의 RBD(Receptor Binding Domain) 내 에피토프와의 결합 여부를 확인하여, 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료용 결합 분자를 선별하는 방법을 제공하는 것이다. In addition, another problem to be solved by the present invention is by confirming whether or not the spike protein (S protein) of SARS-CoV-2 binds to an epitope in the Receptor Binding Domain (RBD). , SARS - to provide a method for screening a binding molecule for diagnosis, prevention or treatment of a disease caused by coronavirus infection.

또한, 본 발명이 해결하고자 하는 다른 과제는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질(Spike protein, S protein)의 RBD(Receptor Binding Domain) 내 에피토프와의 결합 여부를 확인하여, 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료용 결합 분자를 생산하는 방법을 제공한다.In addition, another problem to be solved by the present invention is by confirming whether or not the spike protein (S protein) of SARS-CoV-2 binds to an epitope in the Receptor Binding Domain (RBD). , SARS - provides a method of producing a binding molecule for the diagnosis, prevention or treatment of a disease caused by coronavirus infection.

상기 과제를 해결하고자, 본 발명은 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질(Spike protein, S protein)의 RBD(Receptor Binding Domain) 내 에피토프에 결합하는 사스-코로나바이러스-2 중화 결합 분자로서, 상기 결합 분자의 에피토프가 사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 417, 449, 453, 455, 456, 484, 486, 489, 490, 493, 496 및 505로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 잔기(residue)를 포함하는, 결합 분자를 제공한다. 여기서, 상기 결합 분자의 에피토프는 사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 403, 450, 452, 483, 485, 492, 494 및 495로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 잔기를 추가로 포함할 수 있다. 여기서, 상기 사스-코로나바이러스-2의 스파이크 단백질의 RBD 내 에피토프 아미노산 위치는 SARS-CoV-2의 스파이크 단백질(NCBI Accession No.: YP_009724390.1, 서열번호: 2321)의 N 말단부터 넘버링(numbering) 한 것이다(signal peptide 부터 시작하여 numbering함). In order to solve the above problem, the present invention is SARS-coronavirus-2 that binds to an epitope in the Receptor Binding Domain (RBD) of the spike protein (S protein) of SARS-CoV-2 (SARS-CoV-2) A neutralizing binding molecule, wherein the epitope of the binding molecule is selected from the group consisting of amino acid positions 417, 449, 453, 455, 456, 484, 486, 489, 490, 493, 496 and 505 of the spike protein of SARS-Coronavirus-2. A binding molecule comprising one or more selected amino acid residues is provided. wherein the epitope of the binding molecule further comprises one or more amino acid residues selected from the group consisting of amino acid positions 403, 450, 452, 483, 485, 492, 494 and 495 of the SARS-coronavirus-2 spike protein. can Here, the position of the epitope amino acid in the RBD of the SARS-coronavirus-2 spike protein is numbered from the N-terminus of the SARS-CoV-2 spike protein (NCBI Accession No.: YP_009724390.1, SEQ ID NO: 2321). (numbering starting with signal peptide).

본 발명의 일 구체예에서, 상기 결합 분자의 에피토프는 사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 449, 455, 456, 484, 486, 489, 490 및 493의 아미노산 잔기(residue)를 포함할 수 있다. 여기서, 상기 결합 분자의 에피토프는 사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 450, 452, 485, 492 및 494의 아미노산 잔기(residue)를 추가로 포함할 수 있다. In one embodiment of the present invention, the epitope of the binding molecule comprises amino acid residues at amino acid positions 449, 455, 456, 484, 486, 489, 490 and 493 of the SARS-coronavirus-2 spike protein. can Here, the epitope of the binding molecule may further include amino acid residues at amino acid positions 450, 452, 485, 492 and 494 of the SARS-coronavirus-2 spike protein.

본 발명의 일 구체예에서, 본 발명의 결합 분자는, 사스-코로나바이러스-2, 바람직하게는 사스-코로나바이러스-2의 스파이크 단백질, 더욱 바람직하게는 사스-코로나바이러스-2의 스파이크 단백질의 RBD, 가장 바람직하게는 사스-코로나바이러스-2의 스파이크 단백질의 RBD 내 에피토프를 인식하거나 이에 결합하는 결합 분자로써, 중쇄 가변영역, 바람직하게는 중쇄 가변영역의 CDR1, CDR2 및 CDR3 중 하나 이상의 영역에 파라토프(PARATOPE)를 포함하는 결합 분자를 포함한다. In one embodiment of the present invention, the binding molecule of the present invention is a SARS-coronavirus-2, preferably a SARS-coronavirus-2 spike protein, more preferably a SARS-coronavirus-2 spike protein RBD , Most preferably, as a binding molecule that recognizes or binds to an epitope in the RBD of the SARS-coronavirus-2 spike protein, a heavy chain variable region, preferably a para to one or more of CDR1, CDR2 and CDR3 of the heavy chain variable region binding molecules comprising PARATOPE.

본 발명의 일 구체예에서, 본 발명의 결합 분자는, 중쇄 가변영역의 CDR1에 아미노산 S를 포함하는 것일 수 있으며, 바람직하게는 32번 위치에, S32를 포함하는 것일 수 있다. 일 예로, 상기 중쇄 가변영역의 CDR1은 서열 TSGX11GVX12을 포함하고, 여기서 X11은 M 또는 V이고, X12는 G 또는 S일 수 있다. 가장 바람직하게 본 발명의 중쇄 가변영역의 CDR1은 TSGVGVG을 포함할 수 있다. In one embodiment of the present invention, the binding molecule of the present invention may include the amino acid S in CDR1 of the heavy chain variable region, preferably at position 32, S32. For example, CDR1 of the heavy chain variable region may include the sequence TSGX 11 GVX 12 , wherein X 11 may be M or V, and X 12 may be G or S. Most preferably, CDR1 of the heavy chain variable region of the present invention may include TSGVGVG.

본 발명의 일 구체예에서, 본 발명의 결합 분자는, 중쇄 가변영역의 CDR2에 D, W, N 및 Y 중 하나 이상을 포함하는 것일 수 있으며, 바람직하게는 54, 55, 56, 57, 58 및 60 중 하나 이상의 위치에, 각각 독립적으로 D54, W55, D56, D57, N58 및 Y60을 포함하는 것일 수 있다. 일 예로, 상기 중쇄 가변영역의 CDR2는 서열 LIDWDDNKYX21TTSLKT를 포함하고, 여기서 X21는 Y 또는 H일 수 있다. 가장 바람직하게 본 발명의 중쇄 가변영역의 CDR2는 LIDWDDNKYHTTSLKT을 포함할 수 있다. In one embodiment of the present invention, the binding molecule of the present invention may include one or more of D, W, N and Y in CDR2 of the heavy chain variable region, preferably 54, 55, 56, 57, 58 And at one or more positions of 60, each independently may include D54, W55, D56, D57, N58 and Y60. For example, CDR2 of the heavy chain variable region may include the sequence LIDWDDNKYX 21 TTSLKT, wherein X 21 may be Y or H. Most preferably, CDR2 of the heavy chain variable region of the present invention may include LIDWDDNKYHTTSLKT.

본 발명의 일 구체예에서, 본 발명의 결합 분자는, 중쇄 가변영역의 CDR3에 P, G, L, R 및 Y 중 하나 이상을 포함하는 것일 수 있으며, 바람직하게는 101, 102, 104, 105, 106, 107, 109, 111 및 113 중 하나 이상의 위치에, 각각 독립적으로 P101, G102, L104, R105, Y106, R107, R109, Y111 및 Y113을 포함하는 것일 수 있다. 일 예로, 상기 중쇄 가변영역의 CDR3은 서열 IPGFLRYRNRYYYYGX31DV를 포함하고, 여기서 여기서 X31는 M 또는 V일 수 있다. 가장 바람직하게 본 발명의 중쇄 가변영역의 CDR3은 IPGFLRYRNRYYYYGMDV을 포함할 수 있다. In one embodiment of the present invention, the binding molecule of the present invention may include one or more of P, G, L, R and Y in CDR3 of the heavy chain variable region, preferably 101, 102, 104, 105 , 106, 107, 109, 111, and 113 may each independently include P101, G102, L104, R105, Y106, R107, R109, Y111, and Y113 at one or more positions. For example, CDR3 of the heavy chain variable region includes the sequence IPGFLRYRNRYYYYYGX 31 DV, where X 31 may be M or V. Most preferably, CDR3 of the heavy chain variable region of the present invention may include IPGFLRYRNRYYYYYGMDV.

본 발명의 일 구체예에서, 본 발명의 결합 분자는,중쇄 가변영역의 CDR1의 32번 위치에, S32를 포함하거나; In one embodiment of the present invention, the binding molecule of the present invention comprises, at position 32 of CDR1 of the heavy chain variable region, S32;

중쇄 가변영역의 CDR2의 54, 55, 56, 57, 58 및 60 중 하나 이상의 위치에, 각각 독립적으로 D54, W55, D56, D57, N58 및 Y60을 포함하거나; 및/또는 at one or more positions of 54, 55, 56, 57, 58 and 60 of CDR2 of the heavy chain variable region, each independently comprising D54, W55, D56, D57, N58 and Y60; and/or

중쇄 가변영역의 CDR3의 101, 102, 104, 105, 106, 107, 109, 111 및 113 중 하나 이상의 위치에, 각각 독립적으로 P101, G102, L104, R105, Y106, R107, R109, Y111 및 Y113을 포함하는 것을 포함하나, 이에 한정되지 않는다. At one or more positions of 101, 102, 104, 105, 106, 107, 109, 111 and 113 of CDR3 of the heavy chain variable region, each independently P101, G102, L104, R105, Y106, R107, R109, Y111 and Y113 including, but not limited to.

본 발명의 일 구체예에서, 본 발명에 따른 결합 분자는 서열번호: 832의 CDR1 영역, 서열번호: 833의 CDR2 영역, 및/또는 서열번호: 834의 CDR3 영역을 포함하는 중쇄 가변영역을 포함할 수 있다. In one embodiment of the present invention, the binding molecule according to the present invention will comprise a heavy chain variable region comprising the CDR1 region of SEQ ID NO: 832, the CDR2 region of SEQ ID NO: 833, and/or the CDR3 region of SEQ ID NO: 834. can

본 발명의 일 구체예에서, 본 발명의 결합 분자는 상술한 중쇄 가변영역을 포함하는 결합분자로써, 하기 표 1 및/또는 표 2에 나타낸 경쇄 가변영역이나, 이로부터 유도된 경쇄 가변영역을 포함하는 결합분자를 포함하며, 바람직하게는 서열번호: 829의 CDR1 영역, 서열번호: 830의 CDR2 영역, 및/또는 서열번호: 831의 CDR3 영역을 포함하는 경쇄 가변영역을 포함하나 이에 한정되지 않는다. In one embodiment of the present invention, the binding molecule of the present invention is a binding molecule comprising the above-described heavy chain variable region, and includes the light chain variable region shown in Table 1 and/or Table 2 below, or a light chain variable region derived therefrom. and a light chain variable region comprising the CDR1 region of SEQ ID NO: 829, the CDR2 region of SEQ ID NO: 830, and/or the CDR3 region of SEQ ID NO: 831, preferably, but is not limited thereto.

본 발명의 일 구체예에서, 본 발명의 결합 분자는 상술한 에피토프를 인식하거나 이에 결합하는 결합 분자로써, 하기 표 1 및/또는 표 2에 기재된 결합 분자나, 이로부터 유도된 결합 분자를 포함한다. In one embodiment of the present invention, the binding molecule of the present invention is a binding molecule that recognizes or binds to the above-mentioned epitope, and includes the binding molecules shown in Tables 1 and / or 2 below, or binding molecules derived therefrom. .

또한, 본 발명의 다른 일 구체예에서, 본 발명의 결합 분자는 상술한 에피토프를 인식하거나 이에 결합하는 결합 분자로써, 하기 표 1 및/또는 표 2에 기재된 결합 분자 중 하나 이상을 제외한 결합 분자를 포함한다. In addition, in another embodiment of the present invention, the binding molecule of the present invention is a binding molecule that recognizes or binds to the above-mentioned epitope, and is a binding molecule other than one or more of the binding molecules described in Table 1 and / or Table 2 below. include

본 발명의 일 구체예에서, 상기 결합 분자는 하기 표 1의 결합 분자 No. 89 내지 No. 194, 및 No. 248로 이루어진 군으로부터 선택되는 어느 하나일 수 있다. 하기 표 1에서 No.는 각 결합 분자의 번호를 의미한다.In one embodiment of the present invention, the binding molecule is the binding molecule No. in Table 1 below. 89 to No. 194, and No. It may be any one selected from the group consisting of 248. In Table 1 below, No. means the number of each binding molecule.

Figure pat00001
Figure pat00001

Figure pat00002
Figure pat00002

Figure pat00003
Figure pat00003

Figure pat00004
Figure pat00004

Figure pat00005
Figure pat00005

본 발명에 있어서, 본 발명에 따른 가변영역의 CDR은 Kabat 등에 의해 고안된 시스템에 따라 통상적인 방법으로 결정되었다(문헌[Kabat et al., Sequences of Proteins of Immunological Interest(5th), National Institutes of Health, Bethesda, MD. (1991)] 참조). 본 발명에 사용된 CDR 넘버링은 Kabat 방법을 사용했지만, 이외에 IMGT 방법, Chothia 방법, AbM 방법 등 다른 방법에 따라 결정된 CDR을 포함하는 결합 분자도 본 발명에 포함된다. In the present invention, the CDRs of the variable region according to the present invention were determined by a conventional method according to the system devised by Kabat et al. (Kabat et al., Sequences of Proteins of Immunological Interest (5th), National Institutes of Health, Bethesda, MD. (1991)]. Although the Kabat method was used for CDR numbering used in the present invention, binding molecules comprising CDRs determined according to other methods such as the IMGT method, Chothia method, and AbM method are also included in the present invention.

본 발명의 일 구체예에서, 본 발명에 따른 결합 분자는 하기 표 2의 결합 분자 No. 89 내지 No. 194, 및 No. 248로 이루어진 군으로부터 선택되는 어느 하나일 수 있다. 하기 표 2에서 No.는 각 결합 분자의 번호를 의미한다.In one embodiment of the present invention, the binding molecule according to the present invention is a binding molecule No. in Table 2 below. 89 to No. 194, and No. It may be any one selected from the group consisting of 248. In Table 2 below, No. means the number of each binding molecule.

Figure pat00006
Figure pat00006

Figure pat00007
Figure pat00007

Figure pat00008
Figure pat00008

Figure pat00009
Figure pat00009

Figure pat00010
Figure pat00010

Figure pat00011
Figure pat00011

Figure pat00012
Figure pat00012

Figure pat00013
Figure pat00013

Figure pat00014
Figure pat00014

Figure pat00015
Figure pat00015

Figure pat00016
Figure pat00016

Figure pat00017
Figure pat00017

Figure pat00018
Figure pat00018

본 발명의 일 구체예에서, 본 발명에 따른 결합 분자의 에피토프는 사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 417, 449, 453, 455, 456, 484, 486, 489, 490, 493, 496 및 505의 아미노산 잔기(residue)를 포함할 수 있다. 여기서, 상기 결합 분자의 에피토프는 사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 403, 450, 452, 483, 485, 492, 494 및 495의 아미노산 잔기를 추가로 포함할 수 있다. 본 발명의 일 구체예에서, 상기 결합 분자는 상기 표 1 및/또는 표 2의 결합 분자 No. 89 내지 No. 194, 및 No. 248 로 이루어진 군으로부터 선택되는 어느 하나일 수 있으며, 바람직하게는 표 1의 결합 분자 No. 89 내지 No. 127, No. 129 내지 No. 194, 및 No. 248로 이루어진 군으로부터 선택되는 어느 하나일 수 있다. 본 발명의 일 구체예에서, 상기 결합 분자는 상기 표 2의 결합 분자 No. 89 내지 No. 127, No. 129 내지 No. 194, 및 No. 248로 이루어진 군으로부터 선택되는 어느 하나일 수 있다. In one embodiment of the present invention, the epitope of the binding molecule according to the present invention is at amino acid positions 417, 449, 453, 455, 456, 484, 486, 489, 490, 493, 496 of the SARS-coronavirus-2 spike protein. and an amino acid residue of 505. Here, the epitope of the binding molecule may further include amino acid residues at amino acid positions 403, 450, 452, 483, 485, 492, 494 and 495 of the SARS-coronavirus-2 spike protein. In one embodiment of the present invention, the binding molecule is the binding molecule No. in Table 1 and / or Table 2 above. 89 to No. 194, and No. 248 may be any one selected from the group consisting of, preferably binding molecule No. 89 to No. 127, No. 129 to No. 194, and No. It may be any one selected from the group consisting of 248. In one embodiment of the present invention, the binding molecule is the binding molecule No. in Table 2 above. 89 to No. 127, No. 129 to No. 194, and No. It may be any one selected from the group consisting of 248.

본 발명의 일 구체예에서, 본 발명에 따른 결합 분자의 에피토프는 구조 에피토프(conformational epitope)이다. In one embodiment of the invention, the epitope of the binding molecule according to the invention is a conformational epitope.

본 발명의 일 구체예에서, 본 발명에 따른 결합분자는 사스-코로나바이러스-2의 스파이크 단백질의 RBD에 1x10-8M 이하, 바람직하게는 1x10-9M 이하, 더욱 바람직하게는 1x10-10M 이하의 결합친화도(KD)로 결합할 수 있으나, 이에 한정되는 것은 아니다. 본 발명의 일 실시예에서, 본 발명에 따른 결합 분자는 사스-코로나바이러스-2의 스파이크 단백질의 RBD에 1x10-10 M 이하의 결합 친화도(KD)에서 매우 높은 결합 친화도를 나타내었다. In one embodiment of the present invention, the binding molecule according to the present invention is 1x10 -8 M or less, preferably 1x10 -9 M or less, more preferably 1x10 -10 M to the RBD of the SARS-coronavirus-2 spike protein. It may bind with the following binding affinity (K D ), but is not limited thereto. In one embodiment of the present invention, the binding molecule according to the present invention exhibited a very high binding affinity to the RBD of the SARS-coronavirus-2 spike protein at a binding affinity (K D ) of 1x10 -10 M or less.

본 발명의 일 구체예에서, 본 발명에 따른 결합분자는 크기 배제 크로마토그래피법(Size Exclusion Chromatography, SEC-HPLC)에 따른 모노머(monomer) 비율(%)이 97% 이상, 바람직하게는 98% 이상, 더욱 바람직하게는 99% 이상일 수 있으나, 이에 한정되는 것은 아니다. 본 발명의 일 실시예에서, 본 발명에 따른 결합 분자는 SEC-HPLC에 따른 monomer 비율(%)이 99.87%로, 매우 높은 순도를 보여주었다. In one embodiment of the present invention, the binding molecule according to the present invention has a monomer ratio (%) of 97% or more, preferably 98% or more according to Size Exclusion Chromatography (SEC-HPLC). , more preferably 99% or more, but is not limited thereto. In one embodiment of the present invention, the binding molecule according to the present invention showed a very high purity with a monomer ratio (%) of 99.87% according to SEC-HPLC.

본 발명의 일 구체예에서, 본 발명에 따른 결합분자는 모세관 전기영동 분석 (Capillary Electrophoresis, CE)을 통한 비환원 조건 (Non-reduced condition)에서의 온전한 IgG(Intact IgG)의 순도 비율이 85% 이상, 바람직하게는 86% 이상, 더욱 바람직하게는 87% 이상, 더욱더 바람직하게는 88% 이상, 가장 바람직하게는 89% 이상일 수 있으나, 이에 한정되는 것은 아니다. 본 발명의 일 실시예에서, 본 발명에 따른 결합 분자는 CE를 통한 비환원 조건에서의 Intact IgG의 순도 비율이 89%로, 매우 높은 순도를 보여주었다. In one embodiment of the present invention, the binding molecule according to the present invention has a purity ratio of 85% of intact IgG in non-reduced conditions through capillary electrophoresis (CE). or more, preferably 86% or more, more preferably 87% or more, still more preferably 88% or more, and most preferably 89% or more, but is not limited thereto. In one embodiment of the present invention, the binding molecule according to the present invention showed a very high purity with a purity ratio of Intact IgG of 89% under non-reducing conditions through CE.

본 발명의 일 구체예에서, 본 발명에 따른 결합분자는 모세관 전기영동 분석 (Capillary Electrophoresis, CE)을 통한 환원 조건 (Reduced condition)에서의 항체 중쇄/경쇄합 비율 (Sum of Heavy & Light Chain)이 95% 이상, 바람직하게는 96% 이상, 더욱 바람직하게는 97% 이상, 더욱더 바람직하게는 98% 이상, 가장 바람직하게는 99% 이상일 수 있으나, 이에 한정되는 것은 아니다. 본 발명의 일 실시예에서, 본 발명에 따른 결합 분자는 CE를 통한 환원 조건에서의 항체 중쇄/경쇄합 비율이 99%로, 매우 높은 순도를 보여주었다. In one embodiment of the present invention, the binding molecule according to the present invention has an antibody heavy chain / light chain combination ratio (Sum of Heavy & Light Chain) under reduced conditions through capillary electrophoresis (CE). 95% or more, preferably 96% or more, more preferably 97% or more, still more preferably 98% or more, and most preferably 99% or more, but is not limited thereto. In one embodiment of the present invention, the binding molecule according to the present invention showed a very high purity with an antibody heavy chain/light chain combination ratio of 99% under reducing conditions through CE.

본 발명의 일 구체예에서, 본 발명에 따른 결합분자는 사스-코로나바이러스-2(SARS-CoV-2), 바람직하게는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질, 더욱 바람직하게는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질의 RBD(Receptor Binding Domain)와 표적 세포의 ACE2(Angiotensin-converting enzyme 2) 수용체의 결합을 억제할 수 있다. In one embodiment of the present invention, the binding molecule according to the present invention is a SARS-coronavirus-2 (SARS-CoV-2), preferably a SARS-coronavirus-2 (SARS-CoV-2) spike protein, more Preferably, the SARS-coronavirus-2 (SARS-CoV-2) spike protein RBD (Receptor Binding Domain) and ACE2 (Angiotensin-converting enzyme 2) receptor of the target cell can be inhibited from binding.

본 발명의 일 구체예에서, 본 발명에 따른 결합 분자는 사스-코로나바이러스-2(SARS-CoV-2), 바람직하게는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질, 더욱 바람직하게는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질의 RBD(Receptor Binding Domain)의 결합에 표 1의 결합 분자로 이루어진 군으로부터 선택되는 어느 하나의 결합 분자와 경쟁할 수 있다. 본 발명의 일 구체예에서, 상기 결합 분자는 사스-코로나바이러스-2의 스파이크 단백질의 RBD의 결합에 표 2의 결합 분자로 이루어진 군으로부터 선택되는 어느 하나의 결합 분자와 경쟁할 수 있다. In one embodiment of the present invention, the binding molecule according to the present invention is a spike protein of SARS-coronavirus-2 (SARS-CoV-2), preferably SARS-CoV-2 (SARS-CoV-2), more Preferably, it can compete with any one binding molecule selected from the group consisting of the binding molecules of Table 1 for binding to the receptor binding domain (RBD) of the spike protein of SARS-CoV-2. . In one embodiment of the present invention, the binding molecule may compete with any one binding molecule selected from the group consisting of the binding molecules of Table 2 for binding of the RBD of the SARS-coronavirus-2 spike protein.

본 발명의 일 구체예에서, 본 발명에 따른 결합 분자는 서열번호: 829의 CDR1 영역, 서열번호: 830의 CDR2 영역, 및 서열번호: 831의 CDR3 영역을 포함하는 경쇄 가변영역; 및/또는 서열번호: 832의 CDR1 영역, 서열번호: 833의 CDR2 영역, 및 서열번호: 834의 CDR3 영역을 포함하는 중쇄 가변영역을 포함할 수 있다. In one embodiment of the present invention, the binding molecule according to the present invention comprises a light chain variable region comprising a CDR1 region of SEQ ID NO: 829, a CDR2 region of SEQ ID NO: 830, and a CDR3 region of SEQ ID NO: 831; and/or a heavy chain variable region comprising a CDR1 region of SEQ ID NO: 832, a CDR2 region of SEQ ID NO: 833, and a CDR3 region of SEQ ID NO: 834.

본 발명의 일 구체예에서, 본 발명에 따른 결합 분자는 서열번호: 2017의 폴리펩티드 서열의 경쇄 가변영역; 및 서열번호: 2018의 폴리펩티드 서열의 중쇄 가변영역을 포함할 수 있다. In one embodiment of the present invention, the binding molecule according to the present invention comprises a light chain variable region of the polypeptide sequence of SEQ ID NO: 2017; and a heavy chain variable region of the polypeptide sequence of SEQ ID NO: 2018.

본 발명의 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질(Spike protein, S protein, S 단백질)은 서열번호: 2321의 서열로 구성되거나, 이를 포함하는 것일 수 있으며, 이들의 유도체 및/또는 변이체를 포함하나, 이에 한정되지 않는다.The SARS-coronavirus-2 (SARS-CoV-2) spike protein (S protein) of the present invention may consist of or include the sequence of SEQ ID NO: 2321, and derivatives thereof and/or variants.

본 발명의 일 구체예에서, 본 발명에 따른 결합 분자는 항체 또는 그것의 항원 결합 단편일 수 있다. 본 발명의 일 구체예에서, 상기 결합 분자는 scFv 절편, scFv-Fc 절편, Fab 절편, Fv 절편, 디아바디(diabody), 키메라 항체, 인간화 항체 또는 인간 항체일 수 있으나, 이에 한정되는 것은 아니다. 본 발명의 일 실시예는 SARS-CoV-2 S 단백질에 결합하는 scFv-Fc를 제공한다. 또한, 본 발명의 다른 일 실시예는 SARS-CoV-2 S 단백질에 결합하는 완전한 인간 항체(Full IgG)를 제공한다. In one embodiment of the present invention, the binding molecule according to the present invention may be an antibody or an antigen-binding fragment thereof. In one embodiment of the present invention, the binding molecule may be a scFv fragment, an scFv-Fc fragment, a Fab fragment, an Fv fragment, a diabody, a chimeric antibody, a humanized antibody, or a human antibody, but is not limited thereto. One embodiment of the present invention provides an scFv-Fc that binds to the SARS-CoV-2 S protein. In addition, another embodiment of the present invention provides a fully human antibody (Full IgG) that binds to the SARS-CoV-2 S protein.

본 명세서에서 '항체'는 최대한 넓은 의미로 사용되며, 구체적으로 온전한(intact) 단일클론 항체, 다클론 항체, 2종 이상의 온전한 항체로부터 형성된 다중특이성 항체(예를 들어, 이중특이성 항체), 및 목적하는 생물학적 활성을 나타내는 항체 단편을 포함한다. 항체는 특이적인 항원을 인식하고 결합할 수 있는 면역계에 의하여 생성되는 단백질이다. 그 구조적인 면에서, 항체는 통상적으로 4개의 아미노산 쇄(2개의 중쇄 및 2개의 경쇄)로 이루어진 Y-형상의 단백질을 가진다. 각각의 항체는 주로 가변 영역 및 불변 영역의 2개의 영역을 가진다. Y의 팔의 말단 부분에 위치한 가변 영역은 표적 항원에 결합하고 상호작용한다. 상기 가변 영역은 특정 항원 상의 특이적 결합 부위를 인식하고 결합하는 상보성 결정 영역(CDR)을 포함한다. Y의 꼬리 부분에 위치한 불변 영역은 면역계에 의하여 인식되고 상호작용한다. 표적 항원은 일반적으로 다수의 항체 상의 CDR에 의하여 인식되는, 에피토프라고 하는 다수의 결합 부위를 가지고 있다. 상이한 에피토프에 특이적으로 결합하는 각각의 항체는 상이한 구조를 가진다. 그러므로 한 항원은 하나 이상의 상응하는 항체를 가질 수 있다.As used herein, the term 'antibody' is used in the broadest sense, specifically, an intact monoclonal antibody, a polyclonal antibody, a multispecific antibody formed from two or more intact antibodies (eg, a bispecific antibody), and the purpose antibody fragments that exhibit biological activity. Antibodies are proteins produced by the immune system that are capable of recognizing and binding to specific antigens. In terms of their structure, antibodies usually have a Y-shaped protein consisting of four amino acid chains (two heavy chains and two light chains). Each antibody mainly has two regions: a variable region and a constant region. The variable region located in the distal portion of the arm of Y binds and interacts with the target antigen. The variable region comprises a complementarity determining region (CDR) that recognizes and binds a specific binding site on a specific antigen. The constant region located at the tail of Y is recognized and interacted with by the immune system. Target antigens have multiple binding sites, called epitopes, which are generally recognized by CDRs on multiple antibodies. Each antibody that specifically binds to a different epitope has a different structure. Thus, an antigen may have more than one corresponding antibody.

본 발명의 일 구체예에서, 본 발명에 따른 결합 분자는 상기 결합 분자의 기능적 변이체를 포함한다. 본 발명에 따른 변이체는 SARS-CoV-2 또는 이것의 S 단백질에 특이적으로 결합하기 위해 본 발명의 결합 분자와 경쟁할 수 있다. 본 발명에 있어, SARS-CoV-2에 중화 능력을 보유한다면 본 발명의 결합 분자의 기능적 변이체로 간주된다. 본 발명의 일 구체예에서, 상기 기능적 변이체는 1차 구조적 서열이 실질적으로 유사한 유도체를 포함하지만, 이에 제한되는 것은 아니다. 예를 들면, 상기 기능적 변이체는 생체외(in vitro) 또는 생체내(in vivo) 변형, 화학약품 및/또는 생화학 약품에 의한 변형을 포함한다. 본 발명의 일 구체예에 있어, 상기 기능적 변이체는 본원 발명의 부모 단일클론 항체에서는 발견되지 않는다. 이와 같은 변형으로는 예를 들어 아세틸화, 아실화, 뉴클레오티드 또는 뉴클레오티드 유도체의 공유 결합, 지질 또는 지질 유도체의 공유 결합, 가교, 이황화 결합 형성, 글리코실화, 수산화, 메틸화, 산화, 페길화, 단백질 분해 또는 인산화 등이 포함된다. 본 발명에 있어, 상기 기능적 변이체는 선택적으로 부모 항체의 아미노산 서열과 비교하여 하나 이상의 아미노산의 치환, 삽입, 결실 또는 그들의 조합을 함유하는 아미노산 서열을 포함하는 항체일 수 있다. 본 발명에서, '부모 항체'는 변이가 포함되지 않은 항체를 의미한다. 더욱이, 본 발명에 있어, 상기 기능적 변이체는 아미노 말단 또는 카르복시 말단 중 하나 이상에서 아미노산 서열의 절단체(truncated form)를 포함할 수 있다. 본 발명에 있어, 본 발명의 기능적 변이체는 본 발명의 부모 항체와 비교하여 동일하거나 다르거나, 더 높거나 낮은 결합 친화력을 가질 수 있지만, 여전히 SARS-CoV-2 또는 이것의 S 단백질에 결합할 수 있다. 일 예로, 골격구조, 초가변(Hypervariable) 영역, 특히 경쇄 또는 중쇄의 상보성 결정 영역(Complementarity-determining region, CDR)을 포함하나 이에 한정되지 않는 가변 영역의 아미노산 서열이 변형될 수 있다. 일반적으로 경쇄 또는 중쇄 영역은 3개의 CDR 영역을 포함하는, 3개의 초가변 영역 및 더욱 보존된 영역, 즉 골격 영역(FR)을 포함한다. 일반적으로 초가변 영역은 CDR로부터의 아미노산 잔기와 초가변 루프로부터의 아미노산 잔기를 포함한다. 본 발명의 범위에 속하는 기능적 변이체는 본 발명의 부모 항체와 약 50%~99%, 약 60%~99%, 약 80%~99%, 약 90%~99%, 약 95%~99%, 또는 약 97%~99% 아미노산 서열 동질성을 가질 수 있다. 본 발명에 있어, 비교될 아미노산 서열을 최적으로 배열하고 유사하거나 또는 동일한 아미노산 잔기를 정의하기 위해 컴퓨터 알고리즘 중 당업자에게 알려진 Gap 또는 Bestfit를 사용할 수 있다. 본 발명에 있어, 상기 기능적 변이체는 부모 항체 또는 그것의 일부를 PCR 방법, 올리고머 뉴클레오티드 등을 이용한 돌연변이 생성 및 부분 돌연변이 생성을 포함하는 공지의 분자생물학적 방법에 의해 변화시키거나 유기합성 방법으로 얻을 수 있으나 이에 제한되는 것은 아니다. In one embodiment of the present invention, a binding molecule according to the present invention comprises a functional variant of said binding molecule. The variant according to the present invention may compete with the binding molecule of the present invention for specific binding to SARS-CoV-2 or its S protein. In the present invention, it is regarded as a functional variant of the binding molecule of the present invention if it has the ability to neutralize SARS-CoV-2. In one embodiment of the present invention, the functional variant includes, but is not limited to, derivatives that are substantially similar in primary structural sequence. For example, the functional variant includes in vitro or in vivo modification, modification by chemical and/or biochemical agents. In one embodiment of the present invention, the functional variant is not found in the parental monoclonal antibody of the present invention. Such modifications include, for example, acetylation, acylation, covalent bonding of nucleotides or nucleotide derivatives, covalent bonding of lipids or lipid derivatives, crosslinking, disulfide bond formation, glycosylation, hydroxylation, methylation, oxidation, pegylation, proteolysis. or phosphorylation and the like. In the present invention, the functional variant may be an antibody comprising an amino acid sequence optionally containing one or more amino acid substitutions, insertions, deletions or combinations thereof compared to the amino acid sequence of the parent antibody. In the present invention, the 'parent antibody' refers to an antibody that does not contain mutations. Moreover, in the present invention, the functional variant may include a truncated form of the amino acid sequence at at least one of the amino terminus or the carboxy terminus. In the present invention, functional variants of the present invention may have the same, different, higher or lower binding affinity compared to the parent antibody of the present invention, but still be capable of binding to SARS-CoV-2 or its S protein. have. As an example, the amino acid sequence of a variable region including, but not limited to, a framework structure, a hypervariable region, in particular, a complementarity-determining region (CDR) of a light or heavy chain may be modified. Generally a light or heavy chain region comprises three hypervariable regions, comprising three CDR regions, and a more conserved region, namely a framework region (FR). In general, a hypervariable region comprises amino acid residues from a CDR and amino acid residues from a hypervariable loop. Functional variants within the scope of the present invention include about 50%-99%, about 60%-99%, about 80%-99%, about 90%-99%, about 95%-99%, or about 97%-99% amino acid sequence identity. In the present invention, Gap or Bestfit known to those skilled in the art among computer algorithms may be used to optimally align amino acid sequences to be compared and to define similar or identical amino acid residues. In the present invention, the functional variant may be obtained by changing the parent antibody or a part thereof by a known molecular biological method including PCR method, mutagenesis using oligomeric nucleotides, etc. and partial mutagenesis, or by organic synthesis method. However, the present invention is not limited thereto.

세계보건기구(WHO)는 사스-코로나 바이러스-2를 유전자 염기서열 차이로 인한 아미노산 변화를 기준으로 6개 유형으로 분류하고 있다. 먼저 S, L 유형으로 분류되었다가 다시 L, V, G 유형으로 나뉘고 G가 GH와 GR로 나뉘면서 S, L, V, G, GH, GR 의 총 6개 유형으로 분류하고 있다. COVID-19 발생 초기에 중국 우한을 비롯한 아시아 지역에는 S와 V 유형이 유행하였고, 이후 대륙별로 서로 다른 유형이 발견되었다. 이 중 GH 유형이 전파력이 높게 나타날 가능성이 있다고 보고된 바 있다. 국내의 경우 코로나바이러스 감염증 환자에서 채취한 유전자를 분류한 결과, 대부분은 유럽과 미국에서 유행한 G형의 변종인 GH형인 것으로 나타났고, 이 유형은 바이러스 전파력이 높은 것으로 알려져 있다. 이 중 바이러스의 세포 내 침입 시 중요한 역할을 하는 스파이크 단백질의 614번 아미노산이 아스파트산 (D)에서 글리신 (G)으로 바뀐 G형의 바이러스는 3월 이후 유럽과 미국에서 급격히 증가해 현재는 거의 대부분 지역에서 나타나고 있다. 최근 보고된 바에 따르면 70여개 넘는 코로나바이러스 변이가 발생한 것으로 확인되었고, 전파력이 증가된 변이가 8개 (D614G 등), 중화항체를 회피하는 변이가 10개 (A841V 등), 혈장치료 효과가 낮은 변이 17개 (I472V 등)가 확인되었다. The World Health Organization (WHO) classifies SARS-Coronavirus-2 into six types based on amino acid changes due to differences in gene sequence. First, it was classified into S and L types, then again into L, V, and G types, and as G was divided into GH and GR, it is classified into a total of six types: S, L, V, G, GH, and GR. At the beginning of the COVID-19 outbreak, types S and V were prevalent in Asia including Wuhan, China, and after that, different types were discovered for each continent. Among them, it has been reported that the GH type has the potential to appear high in transmission power. In Korea, as a result of classifying the genes collected from patients with coronavirus infection, most of them were found to be the GH type, a variant of the G type prevalent in Europe and the United States, and this type is known to have high virus transmission power. Among these, type G virus, in which amino acid 614 of the spike protein, which plays an important role in virus invasion, has been changed from aspartic acid (D) to glycine (G), has increased rapidly in Europe and the United States since March, and is now almost It appears in most areas. According to a recent report, more than 70 coronavirus mutations have been identified, 8 mutations with increased transmission power (D614G, etc.), 10 mutations that avoid neutralizing antibodies (A841V, etc.), mutations with low plasma treatment effect 17 (I472V, etc.) were identified.

일 구체예로, 본 발명의 중화 결합 분자는 SARS-CoV-2 바이러스 아미노산 변이 기준으로 S형(S 단백질의 614번 위치의 아미노산이 D), G형(S 단백질의 614번 위치의 아미노산이 G), V형, L형, GH형 및/또는 GR형 등의 균주(strain)에 중화능을 나타낼 수 있으나, 이 균주(strain)에 한정되는 것은 아니다. 상기 SARS-CoV-2 바이러스 S형의 일 예로는 BetaCoV/Korea/KCDC03/2020 균주가 있으나, 이 균주에 한정되는 것은 아니다. 상기 SARS-CoV-2 바이러스 G형의 일 예로는 hCoV-19/South Korea/KUMC17/2020, hCoV-19/South Korea/KCDC9481/2020 균주가 있으나, 이 균주에 한정되는 것은 아니다. 상기 SARS-CoV-2 바이러스 V형의 일 예로는 hCoV-19/Korea/KCDC31/2020 균주가 있으나, 이 균주에 한정되는 것은 아니다. 상기 SARS-CoV-2 바이러스 L형의 일 예로는 hCoV-19/South Korea/KNIH04/2020 균주가 있으나, 이 균주에 한정되는 것은 아니다. 상기 SARS-CoV-2 바이러스 GH형의 일 예로는 hCoV-19/Korea/KCDC10847/2020 균주가 있으나, 이 균주에 한정되는 것은 아니다. 상기 SARS-CoV-2 바이러스 GR형의 일 예로는 hCoV-19/South Korea/KUMC17/2020 균주가 있으나, 이 균주에 한정되는 것은 아니다. 일 실시예로, 본 발명의 중화 결합 분자는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질 S1 부위의 614번 아미노산 위치에서 D614G 변이가 일어난 변이 바이러스에도 우수한 중화능을 나타내었다. 일 실시예로, 본 발명의 중화 결합 분자는 사스-코로나바이러스-2(SARS-CoV-2)의 표면 단백질 (RBD)의 변이 단백질 A435S, F342L, G476S, K458R, N354D, V367F, V483A, 및/또는 W436R에 대해 우수한 결합력을 나타내는 것을 포함한다.In one embodiment, the neutralizing binding molecule of the present invention is S-type (the amino acid at position 614 of the S protein is D), G (the amino acid at position 614 of the S protein is G) based on the SARS-CoV-2 virus amino acid mutation. ), V-type, L-type, GH-type and / or GR-type strains (strain) such as may exhibit neutralizing ability, but is not limited to this strain (strain). An example of the SARS-CoV-2 virus type S is the BetaCoV/Korea/KCDC03/2020 strain, but is not limited thereto. Examples of the SARS-CoV-2 virus type G include, but are not limited to, hCoV-19/South Korea/KUMC17/2020 and hCoV-19/South Korea/KCDC9481/2020 strains. An example of the SARS-CoV-2 virus type V is hCoV-19/Korea/KCDC31/2020 strain, but is not limited thereto. An example of the SARS-CoV-2 virus type L is hCoV-19/South Korea/KNIH04/2020 strain, but is not limited thereto. An example of the SARS-CoV-2 virus type GH is hCoV-19/Korea/KCDC10847/2020 strain, but is not limited thereto. An example of the SARS-CoV-2 virus type GR is hCoV-19/South Korea/KUMC17/2020 strain, but is not limited thereto. In one embodiment, the neutralizing binding molecule of the present invention exhibited excellent neutralizing ability even in a mutant virus in which D614G mutation occurred at amino acid position 614 of the spike protein S1 region of SARS-coronavirus-2 (SARS-CoV-2). In one embodiment, the neutralizing binding molecule of the present invention is SARS-coronavirus-2 (SARS-CoV-2) surface protein (RBD) mutant proteins A435S, F342L, G476S, K458R, N354D, V367F, V483A, and / or exhibiting excellent binding force to W436R.

일 구체예로, 본 발명의 중화 결합 분자는 현재까지 단리된 사스-코로나바이러스-2 균주, 예를 들어 단리 일시와 장소를 알 수 없는 UNKNOWN-LR757996 균주(Strain), SARS-CoV-2/Hu/DP/Kng/19-027 균주; 2019년 12월 중국에서 단리된 Wuhan-Hu-1 균주; 2019년 12월 23일 최초로 중국에서 단리된 BetaCoV/Wuhan/IPBCAMS-WH-01/2019 균주; 2019년 12월 30일 중국에서 단리된 BetaCoV/Wuhan/IPBCAMS-WH-02/2019 균주, BetaCoV/Wuhan/IPBCAMS-WH-03/2019 균주, BetaCoV/Wuhan/IPBCAMS-WH-04/2019 균주, WIV02 균주, WIV04 균주, WIV05 균주, WIV06 균주, WIV07 균주; 2020년 1월 일본에서 단리된 2019-nCoV/Japan/TY/WK-521/2020 균주, 2019-nCoV/Japan/TY/WK-501/2020 균주, 2019-nCoV/Japan/TY/WK-012/2020 균주, 2019-nCoV/Japan/KY/V-029/2020 균주; 2020년 1월 대한민국에서 단리된 SNU01 균주; 대한민국에서 단리된 BetaCoV/Korea/KCDC03/2020 균주; 2020년 1월 1일 중국에서 단리된 BetaCoV/Wuhan/IPBCAMS-WH-05/2020 균주; 2020년 1월 2일 중국에서 단리된 2019-nCoV WHU02 균주, 2019-nCoV WHU01 균주; 2020년 1월 8일 중국에서 단리된 SARS-CoV-2/WH-09/human/2020/CHN 균주; 2020년 1월 10일 중국에서 단리된 2019-nCoV_HKU-SZ-002a_2020 균주; 2020년 1월 11일 중국에서 단리된 2019-nCoV_HKU-SZ-005b_2020 균주; 2020년 1월 17일 중국에서 단리된 SARS-CoV-2/Yunnan-01/human/2020/CHN 균주; 2020년 1월 19일 미국에서 단리된 2019-nCoV/USA-WA1/2020 균주; 2020년 1월 20일 중국에서 단리된 HZ-1 균주; 2020년 1월 21일 미국에서 단리된 2019-nCoV/USA-IL1/2020 균주; 2020년 1월 22일 미국에서 단리된 2019-nCoV/USA-CA2/2020 균주, 2019-nCoV/USA-AZ1/2020 균주; 2020년 1월 23일 미국에서 단리된 2019-nCoV/USA-CA1/2020 균주; 2020년 1월 25일 호주에서 단리된 Australia/VIC01/2020 균주; 2020년 1월 25일 미국에서 단리된 2019-nCoV/USA-WA1-F6/2020 균주, 2019-nCoV/USA-WA1-A12/2020 균주; 2020년 1월 27일 미국에서 단리된 2019-nCoV/USA-CA6/2020 균주; 2020년 1월 28일 미국에서 단리된 2019-nCoV/USA-IL2/2020 균주; 2020년 1월 29일 미국에서 단리된 2019-nCoV/USA-MA1/2020 균주, 2019-nCoV/USA-CA5/2020 균주, 2019-nCoV/USA-CA4/2020 균주, 2019-nCoV/USA-CA3/2020 균주; 2020년 1월 29일 핀란드에서 단리된 nCoV-FIN-29-Jan-2020 균주; 2020년 1월 29일 중국에서 단리된 SARS-CoV-2/IQTC02/human/2020/CHN 균주; 2020년 1월 31일 미국에서 단리된 2019-nCoV/USA-WI1/2020 균주; 2020년 1월 31일 타이완에서 단리된 SARS-CoV-2/NTU01/2020/TWN 균주; 2020년 2월 5일 타이완에서 단리된 SARS-CoV-2/NTU02/2020/TWN 균주; 2020년 2월 6일 미국에서 단리된 2019-nCoV/USA-CA7/2020 균주; 2020년 2월 7일 스웨덴에서 단리된 SARS-CoV-2/01/human/2020/SWE 균주; 2020년 2월 10일 미국에서 단리된 2019-nCoV/USA-CA8/2020 균주; 2020년 2월 11일 미국에서 단리된 2019-nCoV/USA-TX1/2020 균주; 2020년 2월 23일 미국에서 단리된 2019-nCoV/USA-CA9/2020 균주; 2020년 2월 28일 브라질에서 단리된 SARS-CoV-2/SP02/human/2020/BRA 균주; 단리 일시와 장소를 알 수 없는 UNKNOWN-LR757995, UNKNOWN-LR757997, UNKNOWN-LR757998, SARS-CoV-2/Hu/DP/Kng/19-020; 2020년 1월 일본에서 단리된 2019-nCoV/Japan/AI/I-004/2020; 2020년 1월 13일 네팔에서 단리된 SARS0CoV-2/61-TW/human/2020/ NPL; 2020년 2월 5일 중국에서 단리된 SARS-CoV-2/IQTC01/human/2020/CHN 균주; 및/또는 대한민국에서 단리된 hCoV-19/South Korea/KUMC17/2020 균주와 향후 단리될 사스-코로나바이러스-2 균주에 대하여 중화 가능하나, 이들 균주에 한정되는 것은 아니다.In one embodiment, the neutralizing binding molecule of the present invention is a SARS-coronavirus-2 strain isolated to date, for example, UNKNOWN-LR757996 strain (Strain), SARS-CoV-2/Hu of unknown date and place of isolation. /DP/Kng/19-027 strain; Wuhan-Hu-1 strain isolated from China in December 2019; BetaCoV/Wuhan/IPBCAMS-WH-01/2019 strain first isolated in China on December 23, 2019; BetaCoV/Wuhan/IPBCAMS-WH-02/2019 strain, BetaCoV/Wuhan/IPBCAMS-WH-03/2019 strain, BetaCoV/Wuhan/IPBCAMS-WH-04/2019 strain, WIV02 isolated on December 30, 2019 in China strain, WIV04 strain, WIV05 strain, WIV06 strain, WIV07 strain; 2019-nCoV/Japan/TY/WK-521/2020 strain isolated from Japan in January 2020, 2019-nCoV/Japan/TY/WK-501/2020 strain, 2019-nCoV/Japan/TY/WK-012/ 2020 strain, 2019-nCoV/Japan/KY/V-029/2020 strain; SNU01 strain isolated from Korea in January 2020; BetaCoV/Korea/KCDC03/2020 strain isolated from Korea; BetaCoV/Wuhan/IPBCAMS-WH-05/2020 strain isolated from China on January 1, 2020; 2019-nCoV WHU02 strain, 2019-nCoV WHU01 strain isolated on January 2, 2020 in China; SARS-CoV-2/WH-09/human/2020/CHN strain isolated from China on January 8, 2020; 2019-nCoV_HKU-SZ-002a_2020 strain isolated from China on January 10, 2020; 2019-nCoV_HKU-SZ-005b_2020 strain isolated from China on January 11, 2020; SARS-CoV-2/Yunnan-01/human/2020/CHN strain isolated from China on January 17, 2020; 2019-nCoV/USA-WA1/2020 strain isolated in the United States on January 19, 2020; HZ-1 strain isolated in China on January 20, 2020; 2019-nCoV/USA-IL1/2020 strain isolated in the United States on January 21, 2020; 2019-nCoV/USA-CA2/2020 strain, 2019-nCoV/USA-AZ1/2020 strain isolated in the United States on January 22, 2020; 2019-nCoV/USA-CA1/2020 strain isolated in the United States on January 23, 2020; Australia/VIC01/2020 strain isolated in Australia on 25 January 2020; 2019-nCoV/USA-WA1-F6/2020 strain, 2019-nCoV/USA-WA1-A12/2020 strain isolated in the United States on January 25, 2020; 2019-nCoV/USA-CA6/2020 strain isolated in the United States on January 27, 2020; 2019-nCoV/USA-IL2/2020 strain isolated in the United States on January 28, 2020; 2019-nCoV/USA-MA1/2020 strain, 2019-nCoV/USA-CA5/2020 strain, 2019-nCoV/USA-CA4/2020 strain, 2019-nCoV/USA-CA3 isolated in USA on January 29, 2020 /2020 strain; nCoV-FIN-29-Jan-2020 strain isolated on January 29, 2020 in Finland; SARS-CoV-2/IQTC02/human/2020/CHN strain isolated from China on January 29, 2020; 2019-nCoV/USA-WI1/2020 strain isolated in the United States on January 31, 2020; SARS-CoV-2/NTU01/2020/TWN strain isolated in Taiwan on January 31, 2020; SARS-CoV-2/NTU02/2020/TWN strain isolated on February 5, 2020 in Taiwan; 2019-nCoV/USA-CA7/2020 strain isolated in the United States on February 6, 2020; SARS-CoV-2/01/human/2020/SWE strain isolated on February 7, 2020 in Sweden; 2019-nCoV/USA-CA8/2020 strain isolated in the United States on February 10, 2020; 2019-nCoV/USA-TX1/2020 strain isolated in the United States on February 11, 2020; 2019-nCoV/USA-CA9/2020 strain isolated in the United States on February 23, 2020; SARS-CoV-2/SP02/human/2020/BRA strain isolated on February 28, 2020 in Brazil; UNKNOWN-LR757995, UNKNOWN-LR757997, UNKNOWN-LR757998, SARS-CoV-2/Hu/DP/Kng/19-020 of unknown date and place of isolation; 2019-nCoV/Japan/AI/I-004/2020 isolated from Japan in January 2020; SARS0CoV-2/61-TW/human/2020/NPL isolated from Nepal on January 13, 2020; SARS-CoV-2/IQTC01/human/2020/CHN strain isolated from China on February 5, 2020; And/or the hCoV-19/South Korea/KUMC17/2020 strain isolated in Korea and the SARS-coronavirus-2 strain to be isolated in the future can be neutralized, but it is not limited to these strains.

본 발명의 일 구체예에서, 본 발명에 따른 결합 분자는 사스-코로나바이러스-2의 스파이크 단백질에 돌연변이가 생긴 변이 바이러스에 중화능이 있다. 본 발명의 일 구체예에서, 상기 결합 분자는 사스-코로나바이러스-2의 스파이크 단백질의 RBD 영역 이외의 부위에 돌연변이가 생긴 변이 바이러스에 중화능이 있다. In one embodiment of the present invention, the binding molecule according to the present invention has the ability to neutralize a mutant virus in which the SARS-coronavirus-2 spike protein is mutated. In one embodiment of the present invention, the binding molecule has the ability to neutralize a mutant virus having a mutation in a region other than the RBD region of the SARS-coronavirus-2 spike protein.

본 발명의 일 구체예에서, 상기 결합 분자는 사스-코로나바이러스-2 S형, L형, V형, G형, GH형 및/또는 GR형에 중화능이 있으나, 이에 한정되는 것은 아니다. In one embodiment of the present invention, the binding molecule has the ability to neutralize SARS-coronavirus-2 S type, L type, V type, G type, GH type and/or GR type, but is not limited thereto.

본 발명의 일 구체예에서, 상기 결합 분자는 사스-코로나바이러스-2의 스파이크 단백질의 614번 아미노산 위치에서 D614G 변이가 생긴 변이 바이러스에 중화능이 있다. In one embodiment of the present invention, the binding molecule has the ability to neutralize a mutant virus having a D614G mutation at amino acid position 614 of the SARS-coronavirus-2 spike protein.

본 발명의 일 구체예에서, 본 발명의 중화 결합 분자는 하기 1) 내지 76)으로 이루어진 군으로부터 선택되는 어느 하나 이상의 변이 바이러스에 중화능이 있으나, 이 변이 바이러스에 한정되는 것은 아니다:In one embodiment of the present invention, the neutralizing binding molecule of the present invention has the ability to neutralize any one or more mutant viruses selected from the group consisting of the following 1) to 76), but is not limited to this mutant virus:

1) 사스-코로나바이러스-2의 스파이크 단백질의 69번 및 70번 아미노산 위치 중 하나 이상에서 변이가 생긴 변이 바이러스;One) a mutant virus in which at least one of amino acid positions 69 and 70 of the SARS-coronavirus-2 spike protein is mutated;

2) 사스-코로나바이러스-2의 스파이크 단백질의 80번 아미노산 위치에서 변이가 생긴 변이 바이러스;2) Mutant virus in which a mutation occurred at amino acid position 80 of the SARS-coronavirus-2 spike protein;

3) 사스-코로나바이러스-2의 스파이크 단백질의 222번 아미노산 위치에서 변이가 생긴 변이 바이러스;3) Mutant virus in which a mutation occurred at amino acid position 222 of the SARS-coronavirus-2 spike protein;

4) 사스-코로나바이러스-2의 스파이크 단백질의 234번 아미노산 위치에서 변이가 생긴 변이 바이러스;4) a mutant virus in which a mutation occurred at amino acid position 234 of the SARS-coronavirus-2 spike protein;

5) 사스-코로나바이러스-2의 스파이크 단백질의 337번 아미노산 위치에서 변이가 생긴 변이 바이러스;5) a mutant virus in which a mutation occurred at amino acid position 337 of the SARS-coronavirus-2 spike protein;

6) 사스-코로나바이러스-2의 스파이크 단백질의 338번 아미노산 위치에서 변이가 생긴 변이 바이러스;6) a mutant virus in which a mutation occurred at amino acid position 338 of the SARS-coronavirus-2 spike protein;

7) 사스-코로나바이러스-2의 스파이크 단백질의 348번 아미노산 위치에서 변이가 생긴 변이 바이러스;7) a mutant virus in which the 348 amino acid position of the SARS-coronavirus-2 spike protein is mutated;

8) 사스-코로나바이러스-2의 스파이크 단백질의 367번 아미노산 위치에서 변이가 생긴 변이 바이러스;8) Mutant virus in which a mutation occurred at amino acid position 367 of the SARS-coronavirus-2 spike protein;

9) 사스-코로나바이러스-2의 스파이크 단백질의 370번 아미노산 위치에서 변이가 생긴 변이 바이러스;9) a mutant virus in which a mutation occurred at amino acid position 370 of the SARS-coronavirus-2 spike protein;

10) 사스-코로나바이러스-2의 스파이크 단백질의 372번 아미노산 위치에서 변이가 생긴 변이 바이러스;10) a mutant virus in which a mutation occurred at amino acid position 372 of the SARS-coronavirus-2 spike protein;

11) 사스-코로나바이러스-2의 스파이크 단백질의 341번 아미노산 위치에서 변이가 생긴 변이 바이러스;11) a mutant virus in which a mutation occurred at amino acid position 341 of the SARS-coronavirus-2 spike protein;

12) 사스-코로나바이러스-2의 스파이크 단백질의 342번 아미노산 위치에서 변이가 생긴 변이 바이러스;12) Mutant virus in which a mutation occurred at amino acid position 342 of the SARS-coronavirus-2 spike protein;

13) 사스-코로나바이러스-2의 스파이크 단백질의 344번 아미노산 위치에서 변이가 생긴 변이 바이러스;13) Mutant virus in which a mutation occurred at amino acid position 344 of the SARS-coronavirus-2 spike protein;

14) 사스-코로나바이러스-2의 스파이크 단백질의 352번 아미노산 위치에서 변이가 생긴 변이 바이러스;14) a mutant virus in which a mutation occurred at amino acid position 352 of the SARS-coronavirus-2 spike protein;

15) 사스-코로나바이러스-2의 스파이크 단백질의 354번 아미노산 위치에서 변이가 생긴 변이 바이러스;15) Mutant virus in which a mutation occurred at amino acid position 354 of the SARS-coronavirus-2 spike protein;

16) 사스-코로나바이러스-2의 스파이크 단백질의 359번 아미노산 위치에서 변이가 생긴 변이 바이러스;16) Mutant virus in which a mutation occurred at amino acid position 359 of the SARS-coronavirus-2 spike protein;

17) 사스-코로나바이러스-2의 스파이크 단백질의 377번 아미노산 위치에서 변이가 생긴 변이 바이러스;17) Mutant virus in which a mutation occurred at amino acid position 377 of the SARS-coronavirus-2 spike protein;

18) 사스-코로나바이러스-2의 스파이크 단백질의 378번 아미노산 위치에서 변이가 생긴 변이 바이러스;18) a mutant virus in which a mutation occurred at amino acid position 378 of the SARS-coronavirus-2 spike protein;

19) 사스-코로나바이러스-2의 스파이크 단백질의 384번 아미노산 위치에서 변이가 생긴 변이 바이러스;19) a mutant virus in which a mutation occurred at amino acid position 384 of the SARS-coronavirus-2 spike protein;

20) 사스-코로나바이러스-2의 스파이크 단백질의 385번 아미노산 위치에서 변이가 생긴 변이 바이러스;20) Mutant virus in which a mutation occurred at amino acid position 385 of the SARS-coronavirus-2 spike protein;

21) 사스-코로나바이러스-2의 스파이크 단백질의 393번 아미노산 위치에서 변이가 생긴 변이 바이러스;21) Mutant virus in which a mutation occurred at amino acid position 393 of the SARS-coronavirus-2 spike protein;

22) 사스-코로나바이러스-2의 스파이크 단백질의 395번 아미노산 위치에서 변이가 생긴 변이 바이러스;22) Mutant virus in which a mutation occurred at amino acid position 395 of the SARS-coronavirus-2 spike protein;

23) 사스-코로나바이러스-2의 스파이크 단백질의 405번 아미노산 위치에서 변이가 생긴 변이 바이러스;23) a mutant virus in which a mutation occurred at amino acid position 405 of the SARS-coronavirus-2 spike protein;

24) 사스-코로나바이러스-2의 스파이크 단백질의 406번 아미노산 위치에서 변이가 생긴 변이 바이러스;24) Mutant virus in which a mutation occurred at amino acid position 406 of the SARS-coronavirus-2 spike protein;

25) 사스-코로나바이러스-2의 스파이크 단백질의 408번 아미노산 위치에서 변이가 생긴 변이 바이러스;25) a mutant virus in which a mutation occurred at amino acid position 408 of the SARS-coronavirus-2 spike protein;

26) 사스-코로나바이러스-2의 스파이크 단백질의 409번 아미노산 위치에서 변이가 생긴 변이 바이러스;26) a mutant virus in which a mutation occurred at amino acid position 409 of the SARS-coronavirus-2 spike protein;

27) 사스-코로나바이러스-2의 스파이크 단백질의 414번 아미노산 위치에서 변이가 생긴 변이 바이러스;27) Mutant virus in which a mutation occurred at amino acid position 414 of the SARS-coronavirus-2 spike protein;

28) 사스-코로나바이러스-2의 스파이크 단백질의 417번 아미노산 위치에서 변이가 생긴 변이 바이러스;28) Mutant virus in which a mutation occurred at amino acid position 417 of the SARS-coronavirus-2 spike protein;

29) 사스-코로나바이러스-2의 스파이크 단백질의 420번 아미노산 위치에서 변이가 생긴 변이 바이러스;29) a mutant virus in which a mutation occurred at amino acid position 420 of the SARS-coronavirus-2 spike protein;

30) 사스-코로나바이러스-2의 스파이크 단백질의 435번 아미노산 위치에서 변이가 생긴 변이 바이러스;30) Mutant virus in which a mutation occurred at amino acid position 435 of the SARS-coronavirus-2 spike protein;

31) 사스-코로나바이러스-2의 스파이크 단백질의 436번 아미노산 위치에서 변이가 생긴 변이 바이러스;31) Mutant virus in which a mutation occurred at amino acid position 436 of the SARS-coronavirus-2 spike protein;

32) 사스-코로나바이러스-2의 스파이크 단백질의 439번 아미노산 위치에서 변이가 생긴 변이 바이러스;32) Mutant virus in which a mutation occurred at amino acid position 439 of the SARS-coronavirus-2 spike protein;

33) 사스-코로나바이러스-2의 스파이크 단백질의 440번 아미노산 위치에서 변이가 생긴 변이 바이러스;33) Mutant virus in which a mutation occurred at amino acid position 440 of the SARS-coronavirus-2 spike protein;

34) 사스-코로나바이러스-2의 스파이크 단백질의 444번 아미노산 위치에서 K444Q 변이 또는 K444R 변이가 생긴 변이 바이러스;34) a mutant virus in which K444Q mutation or K444R mutation occurs at amino acid position 444 of the SARS-coronavirus-2 spike protein;

35) 사스-코로나바이러스-2의 스파이크 단백질의 445번 아미노산 위치에서 변이가 생긴 변이 바이러스;35) Mutant virus in which a mutation occurred at amino acid position 445 of the SARS-coronavirus-2 spike protein;

36) 사스-코로나바이러스-2의 스파이크 단백질의 446번 아미노산 위치에서 변이가 생긴 변이 바이러스;36) Mutant virus in which a mutation occurred at amino acid position 446 of the SARS-coronavirus-2 spike protein;

37) 사스-코로나바이러스-2의 스파이크 단백질의 449번 아미노산 위치에서 변이가 생긴 변이 바이러스;37) Mutant virus in which a mutation occurred at amino acid position 449 of the SARS-coronavirus-2 spike protein;

38) 사스-코로나바이러스-2의 스파이크 단백질의 452번 아미노산 위치에서 변이가 생긴 변이 바이러스;38) Mutant virus in which a mutation occurred at amino acid position 452 of the SARS-coronavirus-2 spike protein;

39) 사스-코로나바이러스-2의 스파이크 단백질의 453번 아미노산 위치에서 변이가 생긴 변이 바이러스;39) Mutant virus in which a mutation occurred at amino acid position 453 of the SARS-coronavirus-2 spike protein;

40) 사스-코로나바이러스-2의 스파이크 단백질의 455번 아미노산 위치에서 변이가 생긴 변이 바이러스;40) Mutant virus in which a mutation occurred at amino acid position 455 of the SARS-coronavirus-2 spike protein;

41) 사스-코로나바이러스-2의 스파이크 단백질의 456번 아미노산 위치에서 변이가 생긴 변이 바이러스;41) Mutant virus in which a mutation occurred at amino acid position 456 of the SARS-coronavirus-2 spike protein;

42) 사스-코로나바이러스-2의 스파이크 단백질의 458번 아미노산 위치에서 변이가 생긴 변이 바이러스;42) a mutant virus in which a mutation occurred at amino acid position 458 of the SARS-coronavirus-2 spike protein;

43) 사스-코로나바이러스-2의 스파이크 단백질의 460번 아미노산 위치에서 변이가 생긴 변이 바이러스;43) Mutant virus in which a mutation occurred at amino acid position 460 of the SARS-coronavirus-2 spike protein;

44) 사스-코로나바이러스-2의 스파이크 단백질의 471번 아미노산 위치에서 변이가 생긴 변이 바이러스;44) Mutant virus in which a mutation occurred at amino acid position 471 of the SARS-coronavirus-2 spike protein;

45) 사스-코로나바이러스-2의 스파이크 단백질의 472번 아미노산 위치에서 변이가 생긴 변이 바이러스;45) A mutant virus in which a mutation occurred at amino acid position 472 of the SARS-coronavirus-2 spike protein;

46) 사스-코로나바이러스-2의 스파이크 단백질의 473번 아미노산 위치에서 변이가 생긴 변이 바이러스;46) Mutant virus in which a mutation occurred at amino acid position 473 of the SARS-coronavirus-2 spike protein;

47) 사스-코로나바이러스-2의 스파이크 단백질의 475번 아미노산 위치에서 변이가 생긴 변이 바이러스;47) Mutant virus in which a mutation occurred at amino acid position 475 of the SARS-coronavirus-2 spike protein;

48) 사스-코로나바이러스-2의 스파이크 단백질의 476번 아미노산 위치에서 변이가 생긴 변이 바이러스;48) Mutant virus in which a mutation occurred at amino acid position 476 of the SARS-coronavirus-2 spike protein;

49) 사스-코로나바이러스-2의 스파이크 단백질의 477번 아미노산 위치에서 변이가 생긴 변이 바이러스;49) Mutant virus in which a mutation occurred at amino acid position 477 of the SARS-coronavirus-2 spike protein;

50) 사스-코로나바이러스-2의 스파이크 단백질의 478번 아미노산 위치에서 변이가 생긴 변이 바이러스;50) Mutant virus in which a mutation occurred at amino acid position 478 of the SARS-coronavirus-2 spike protein;

51) 사스-코로나바이러스-2의 스파이크 단백질의 479번 아미노산 위치에서 변이가 생긴 변이 바이러스;51) Mutant virus in which a mutation occurred at amino acid position 479 of the SARS-coronavirus-2 spike protein;

52) 사스-코로나바이러스-2의 스파이크 단백질의 481번 아미노산 위치에서 변이가 생긴 변이 바이러스;52) Mutant virus in which a mutation occurred at amino acid position 481 of the SARS-coronavirus-2 spike protein;

53) 사스-코로나바이러스-2의 스파이크 단백질의 482번 아미노산 위치에서 변이가 생긴 변이 바이러스;53) Mutant virus in which a mutation occurred at amino acid position 482 of the SARS-coronavirus-2 spike protein;

54) 사스-코로나바이러스-2의 스파이크 단백질의 483번 아미노산 위치에서 변이가 생긴 변이 바이러스;54) Mutant virus in which a mutation occurred at amino acid position 483 of the SARS-coronavirus-2 spike protein;

55) 사스-코로나바이러스-2의 스파이크 단백질의 484번 아미노산 위치에서 변이가 생긴 변이 바이러스;55) Mutant virus in which a mutation occurred at amino acid position 484 of the SARS-coronavirus-2 spike protein;

56) 사스-코로나바이러스-2의 스파이크 단백질의 485번 아미노산 위치에서 생긴 변이 바이러스;56) a mutant virus occurring at amino acid position 485 of the SARS-coronavirus-2 spike protein;

57) 사스-코로나바이러스-2의 스파이크 단백질의 486번 아미노산 위치에서 변이가 생긴 변이 바이러스;57) Mutant virus in which a mutation occurred at amino acid position 486 of the SARS-coronavirus-2 spike protein;

58) 사스-코로나바이러스-2의 스파이크 단백질의 489번 아미노산 위치에서 변이가 생긴 변이 바이러스;58) Mutant virus in which a mutation occurred at amino acid position 489 of the SARS-coronavirus-2 spike protein;

59) 사스-코로나바이러스-2의 스파이크 단백질의 490번 아미노산 위치에서 변이가 생긴 변이 바이러스;59) a mutant virus in which a mutation occurred at amino acid position 490 of the SARS-coronavirus-2 spike protein;

60) 사스-코로나바이러스-2의 스파이크 단백질의 493번 아미노산 위치에서 변이가 생긴 변이 바이러스;60) Mutant virus in which a mutation occurred at amino acid position 493 of the SARS-coronavirus-2 spike protein;

61) 사스-코로나바이러스-2의 스파이크 단백질의 494번 아미노산 위치에서 변이가 생긴 변이 바이러스;61) Mutant virus in which a mutation occurred at amino acid position 494 of the SARS-coronavirus-2 spike protein;

62) 사스-코로나바이러스-2의 스파이크 단백질의 498번 아미노산 위치에서 변이가 생긴 변이 바이러스;62) a mutant virus in which a mutation occurred at amino acid position 498 of the SARS-coronavirus-2 spike protein;

63) 사스-코로나바이러스-2의 스파이크 단백질의 499번 아미노산 위치에서 변이가 생긴 변이 바이러스;63) Mutant virus in which a mutation occurred at amino acid position 499 of the SARS-coronavirus-2 spike protein;

64) 사스-코로나바이러스-2의 스파이크 단백질의 501번 아미노산 위치에서 변이가 생긴 변이 바이러스;64) Mutant virus in which a mutation occurred at amino acid position 501 of the SARS-coronavirus-2 spike protein;

65) 사스-코로나바이러스-2의 스파이크 단백질의 503번 아미노산 위치에서 변이가 생긴 변이 바이러스;65) Mutant virus in which a mutation occurred at amino acid position 503 of the SARS-coronavirus-2 spike protein;

66) 사스-코로나바이러스-2의 스파이크 단백질의 505번 아미노산 위치에서 변이가 생긴 변이 바이러스;66) a mutant virus in which a mutation occurred at amino acid position 505 of the SARS-coronavirus-2 spike protein;

67) 사스-코로나바이러스-2의 스파이크 단백질의 508번 아미노산 위치에서 변이가 생긴 변이 바이러스;67) Mutant virus in which a mutation occurred at amino acid position 508 of the SARS-coronavirus-2 spike protein;

68) 사스-코로나바이러스-2의 스파이크 단백질의 520번 아미노산 위치에서 변이가 생긴 변이 바이러스;68) Mutant virus in which a mutation occurred at amino acid position 520 of the SARS-coronavirus-2 spike protein;

69) 사스-코로나바이러스-2의 스파이크 단백질의 521번 아미노산 위치에서 변이가 생긴 변이 바이러스;69) Mutant virus in which a mutation occurred at amino acid position 521 of the SARS-coronavirus-2 spike protein;

70) 사스-코로나바이러스-2의 스파이크 단백질의 522번 아미노산 위치에서 변이가 생긴 변이 바이러스;70) Mutant virus in which a mutation occurred at amino acid position 522 of the SARS-coronavirus-2 spike protein;

71) 사스-코로나바이러스-2의 스파이크 단백질의 614번 아미노산 위치에서 변이가 생긴 변이 바이러스;71) Mutant virus in which a mutation occurred at amino acid position 614 of the SARS-coronavirus-2 spike protein;

72) 사스-코로나바이러스-2의 스파이크 단백질의 677번 아미노산 위치에서 변이가 생긴 변이 바이러스;72) Mutant virus in which a mutation occurred at amino acid position 677 of the SARS-coronavirus-2 spike protein;

73) 사스-코로나바이러스-2의 스파이크 단백질의 681번 아미노산 위치에서 변이가 생긴 변이 바이러스;73) Mutant virus in which a mutation occurred at amino acid position 681 of the SARS-coronavirus-2 spike protein;

74) 사스-코로나바이러스-2의 스파이크 단백질의 685번 아미노산 위치에서 변이가 생긴 변이 바이러스; 74) Mutant virus in which a mutation occurred at amino acid position 685 of the SARS-coronavirus-2 spike protein;

75) 사스-코로나바이러스-2의 스파이크 단백질의 701번 아미노산 위치에서 변이가 생긴 변이 바이러스;75) a mutant virus in which a mutation occurred at amino acid position 701 of the SARS-coronavirus-2 spike protein;

및and

76) 사스-코로나바이러스-2의 스파이크 단백질의 1176번 아미노산 위치에서 변이가 생긴 변이 바이러스.76) A mutant virus with a mutation at amino acid position 1176 of the SARS-coronavirus-2 spike protein.

본 발명의 일 구체예에서, 본 발명의 중화 결합 분자는 하기 1) 내지 76)으로 이루어진 군으로부터 선택되는 어느 하나 이상의 변이 바이러스에 중화능이 있으나, 이 변이 바이러스에 한정되는 것은 아니다:In one embodiment of the present invention, the neutralizing binding molecule of the present invention has the ability to neutralize any one or more mutant viruses selected from the group consisting of the following 1) to 76), but is not limited to this mutant virus:

1) 사스-코로나바이러스-2의 스파이크 단백질의 69번 및 70번 아미노산 위치 중 하나 이상이 결실된 변이 바이러스;One) a mutant virus in which at least one of amino acid positions 69 and 70 of the SARS-coronavirus-2 spike protein is deleted;

2) 사스-코로나바이러스-2의 스파이크 단백질의 80번 아미노산 위치에서 D80A 변이가 생긴 변이 바이러스;2) a mutant virus having a D80A mutation at amino acid position 80 of the SARS-coronavirus-2 spike protein;

3) 사스-코로나바이러스-2의 스파이크 단백질의 222번 아미노산 위치에서 A222V 변이가 생긴 변이 바이러스;3) A mutant virus with A222V mutation at amino acid position 222 of the SARS-coronavirus-2 spike protein;

4) 사스-코로나바이러스-2의 스파이크 단백질의 234번 아미노산 위치에서 N234Q 변이가 생긴 변이 바이러스;4) a mutant virus having N234Q mutation at amino acid position 234 of the SARS-coronavirus-2 spike protein;

5) 사스-코로나바이러스-2의 스파이크 단백질의 337번 아미노산 위치에서 P337S 변이가 생긴 변이 바이러스;5) a mutant virus in which a P337S mutation occurred at amino acid position 337 of the SARS-coronavirus-2 spike protein;

6) 사스-코로나바이러스-2의 스파이크 단백질의 338번 아미노산 위치에서 F338L 변이가 생긴 변이 바이러스;6) a mutant virus having F338L mutation at amino acid position 338 of the SARS-coronavirus-2 spike protein;

7) 사스-코로나바이러스-2의 스파이크 단백질의 348번 아미노산 위치에서 A348S 변이가 생긴 변이 바이러스;7) A mutant virus having an A348S mutation at amino acid position 348 of the SARS-coronavirus-2 spike protein;

8) 사스-코로나바이러스-2의 스파이크 단백질의 367번 아미노산 위치에서 V367F 변이가 생긴 변이 바이러스;8) a mutant virus having a V367F mutation at amino acid position 367 of the SARS-coronavirus-2 spike protein;

9) 사스-코로나바이러스-2의 스파이크 단백질의 370번 아미노산 위치에서 N370S 변이가 생긴 변이 바이러스;9) a mutant virus with N370S mutation at amino acid position 370 of the SARS-coronavirus-2 spike protein;

10) 사스-코로나바이러스-2의 스파이크 단백질의 372번 아미노산 위치에서 A372S 변이, A372T 변이 또는 A372V 변이가 생긴 변이 바이러스;10) A mutant virus having A372S mutation, A372T mutation, or A372V mutation at amino acid position 372 of the SARS-coronavirus-2 spike protein;

11) 사스-코로나바이러스-2의 스파이크 단백질의 341번 아미노산 위치에서 V341I 변이가 생긴 변이 바이러스;11) a mutant virus in which V341I mutation occurred at amino acid position 341 of the SARS-coronavirus-2 spike protein;

12) 사스-코로나바이러스-2의 스파이크 단백질의 342번 아미노산 위치에서 F342L 변이가 생긴 변이 바이러스;12) a mutant virus having F342L mutation at amino acid position 342 of the SARS-coronavirus-2 spike protein;

13) 사스-코로나바이러스-2의 스파이크 단백질의 344번 아미노산 위치에서 A344S 변이가 생긴 변이 바이러스;13) A mutant virus having an A344S mutation at amino acid position 344 of the SARS-coronavirus-2 spike protein;

14) 사스-코로나바이러스-2의 스파이크 단백질의 352번 아미노산 위치에서 A352S 변이가 생긴 변이 바이러스;14) A mutant virus in which A352S mutation occurred at amino acid position 352 of the SARS-coronavirus-2 spike protein;

15) 사스-코로나바이러스-2의 스파이크 단백질의 354번 아미노산 위치에서 N354D 변이가 생긴 변이 바이러스;15) a mutant virus with N354D mutation at amino acid position 354 of the SARS-coronavirus-2 spike protein;

16) 사스-코로나바이러스-2의 스파이크 단백질의 359번 아미노산 위치에서 S359N 변이가 생긴 변이 바이러스;16) a mutant virus having S359N mutation at amino acid position 359 of the SARS-coronavirus-2 spike protein;

17) 사스-코로나바이러스-2의 스파이크 단백질의 377번 아미노산 위치에서 F377L 변이가 생긴 변이 바이러스;17) a mutant virus having F377L mutation at amino acid position 377 of the SARS-coronavirus-2 spike protein;

18) 사스-코로나바이러스-2의 스파이크 단백질의 378번 아미노산 위치에서 K378R 변이 또는 K378N 변이가 생긴 변이 바이러스;18) a mutant virus having K378R mutation or K378N mutation at amino acid position 378 of the SARS-coronavirus-2 spike protein;

19) 사스-코로나바이러스-2의 스파이크 단백질의 384번 아미노산 위치에서 P384L 변이가 생긴 변이 바이러스;19) a mutant virus in which P384L mutation occurred at amino acid position 384 of the SARS-coronavirus-2 spike protein;

20) 사스-코로나바이러스-2의 스파이크 단백질의 385번 아미노산 위치에서 T385A 변이가 생긴 변이 바이러스;20) a mutant virus having T385A mutation at amino acid position 385 of the SARS-coronavirus-2 spike protein;

21) 사스-코로나바이러스-2의 스파이크 단백질의 393번 아미노산 위치에서 T393P 변이가 생긴 변이 바이러스;21) a mutant virus having T393P mutation at amino acid position 393 of the SARS-coronavirus-2 spike protein;

22) 사스-코로나바이러스-2의 스파이크 단백질의 395번 아미노산 위치에서 V395I 변이가 생긴 변이 바이러스;22) a mutant virus in which the V395I mutation occurred at amino acid position 395 of the SARS-coronavirus-2 spike protein;

23) 사스-코로나바이러스-2의 스파이크 단백질의 405번 아미노산 위치에서 D405V 변이가 생긴 변이 바이러스;23) a mutant virus having a D405V mutation at amino acid position 405 of the SARS-coronavirus-2 spike protein;

24) 사스-코로나바이러스-2의 스파이크 단백질의 406번 아미노산 위치에서 E406Q 변이 또는 E406W 변이가 생긴 변이 바이러스;24) a mutant virus having E406Q mutation or E406W mutation at amino acid position 406 of the SARS-coronavirus-2 spike protein;

25) 사스-코로나바이러스-2의 스파이크 단백질의 408번 아미노산 위치에서 R408I 변이가 생긴 변이 바이러스;25) a mutant virus having R408I mutation at amino acid position 408 of the SARS-coronavirus-2 spike protein;

26) 사스-코로나바이러스-2의 스파이크 단백질의 409번 아미노산 위치에서 Q409E 변이가 생긴 변이 바이러스;26) a mutant virus having Q409E mutation at amino acid position 409 of the SARS-coronavirus-2 spike protein;

27) 사스-코로나바이러스-2의 스파이크 단백질의 414번 아미노산 위치에서 Q414A 변이, Q414E 변이 또는 Q414R 변이가 생긴 변이 바이러스;27) a mutant virus having Q414A mutation, Q414E mutation, or Q414R mutation at amino acid position 414 of the SARS-coronavirus-2 spike protein;

28) 사스-코로나바이러스-2의 스파이크 단백질의 417번 아미노산 위치에서 K417N 변이, K417T 변이 또는 K417E 변이가 생긴 변이 바이러스;28) a mutant virus having K417N mutation, K417T mutation or K417E mutation at amino acid position 417 of the SARS-coronavirus-2 spike protein;

29) 사스-코로나바이러스-2의 스파이크 단백질의 420번 아미노산 위치에서 D420N 변이가 생긴 변이 바이러스;29) a mutant virus with a D420N mutation at amino acid position 420 of the SARS-coronavirus-2 spike protein;

30) 사스-코로나바이러스-2의 스파이크 단백질의 435번 아미노산 위치에서 A435S 변이가 생긴 변이 바이러스;30) A mutant virus having an A435S mutation at amino acid position 435 of the SARS-coronavirus-2 spike protein;

31) 사스-코로나바이러스-2의 스파이크 단백질의 436번 아미노산 위치에서 W436R 변이가 생긴 변이 바이러스;31) a mutant virus having a W436R mutation at amino acid position 436 of the SARS-coronavirus-2 spike protein;

32) 사스-코로나바이러스-2의 스파이크 단백질의 439번 아미노산 위치에서 N439K 변이가 생긴 변이 바이러스;32) a mutant virus having N439K mutation at amino acid position 439 of the SARS-coronavirus-2 spike protein;

33) 사스-코로나바이러스-2의 스파이크 단백질의 440번 아미노산 위치에서 N440K 변이 또는 N440D 변이가 생긴 변이 바이러스;33) a mutant virus having N440K mutation or N440D mutation at amino acid position 440 of the SARS-coronavirus-2 spike protein;

34) 사스-코로나바이러스-2의 스파이크 단백질의 444번 아미노산 위치에서 K444Q 변이 또는 K444R 변이가 생긴 변이 바이러스;34) a mutant virus in which K444Q mutation or K444R mutation occurs at amino acid position 444 of the SARS-coronavirus-2 spike protein;

35) 사스-코로나바이러스-2의 스파이크 단백질의 445번 아미노산 위치에서 V445A 변이 또는 V445F 변이가 생긴 변이 바이러스;35) a mutant virus having V445A mutation or V445F mutation at amino acid position 445 of the SARS-coronavirus-2 spike protein;

36) 사스-코로나바이러스-2의 스파이크 단백질의 446번 아미노산 위치에서 G446V 변이 또는 G446S 변이가 생긴 변이 바이러스;36) a mutant virus having a G446V mutation or a G446S mutation at amino acid position 446 of the SARS-coronavirus-2 spike protein;

37) 사스-코로나바이러스-2의 스파이크 단백질의 449번 아미노산 위치에서 Y449N 변이가 생긴 변이 바이러스;37) a mutant virus in which Y449N mutation occurred at amino acid position 449 of the SARS-coronavirus-2 spike protein;

38) 사스-코로나바이러스-2의 스파이크 단백질의 452번 아미노산 위치에서 L452R 변이가 생긴 변이 바이러스;38) a mutant virus having L452R mutation at amino acid position 452 of the SARS-coronavirus-2 spike protein;

39) 사스-코로나바이러스-2의 스파이크 단백질의 453번 아미노산 위치에서 Y453F 변이가 생긴 변이 바이러스;39) a mutant virus having a Y453F mutation at amino acid position 453 of the SARS-coronavirus-2 spike protein;

40) 사스-코로나바이러스-2의 스파이크 단백질의 455번 아미노산 위치에서 L455F 변이가 생긴 변이 바이러스;40) a mutant virus having L455F mutation at amino acid position 455 of the SARS-coronavirus-2 spike protein;

41) 사스-코로나바이러스-2의 스파이크 단백질의 456번 아미노산 위치에서 F456L 변이 또는 F456E 변이가 생긴 변이 바이러스;41) a mutant virus having F456L mutation or F456E mutation at amino acid position 456 of the SARS-coronavirus-2 spike protein;

42) 사스-코로나바이러스-2의 스파이크 단백질의 458번 아미노산 위치에서 K458R 변이 또는 K458Q 변이가 생긴 변이 바이러스;42) a mutant virus having K458R mutation or K458Q mutation at amino acid position 458 of the SARS-coronavirus-2 spike protein;

43) 사스-코로나바이러스-2의 스파이크 단백질의 460번 아미노산 위치에서 N460T 변이가 생긴 변이 바이러스;43) a mutant virus in which N460T mutation occurred at amino acid position 460 of the SARS-coronavirus-2 spike protein;

44) 사스-코로나바이러스-2의 스파이크 단백질의 471번 아미노산 위치에서 E471Q 변이가 생긴 변이 바이러스;44) a mutant virus having E471Q mutation at amino acid position 471 of the SARS-coronavirus-2 spike protein;

45) 사스-코로나바이러스-2의 스파이크 단백질의 472번 아미노산 위치에서 I472V 변이가 생긴 변이 바이러스;45) A mutant virus with I472V mutation at amino acid position 472 of the SARS-coronavirus-2 spike protein;

46) 사스-코로나바이러스-2의 스파이크 단백질의 473번 아미노산 위치에서 Y473F 변이가 생긴 변이 바이러스;46) a mutant virus in which Y473F mutation occurred at amino acid position 473 of the SARS-coronavirus-2 spike protein;

47) 사스-코로나바이러스-2의 스파이크 단백질의 475번 아미노산 위치에서 A475V 변이가 생긴 변이 바이러스;47) A mutant virus having A475V mutation at amino acid position 475 of the SARS-coronavirus-2 spike protein;

48) 사스-코로나바이러스-2의 스파이크 단백질의 476번 아미노산 위치에서 G476S 변이가 생긴 변이 바이러스;48) a mutant virus having a G476S mutation at amino acid position 476 of the SARS-coronavirus-2 spike protein;

49) 사스-코로나바이러스-2의 스파이크 단백질의 477번 아미노산 위치에서 S477N 변이, S477R 변이, S477I 변이 또는 S477R 변이가 생긴 변이 바이러스;49) a mutant virus having S477N mutation, S477R mutation, S477I mutation or S477R mutation at amino acid position 477 of the SARS-coronavirus-2 spike protein;

50) 사스-코로나바이러스-2의 스파이크 단백질의 478번 아미노산 위치에서 T478K 변이 또는 T478I 변이가 생긴 변이 바이러스;50) a mutant virus having T478K mutation or T478I mutation at amino acid position 478 of the SARS-coronavirus-2 spike protein;

51) 사스-코로나바이러스-2의 스파이크 단백질의 479번 아미노산 위치에서 P479S 변이가 생긴 변이 바이러스;51) a mutant virus in which a P479S mutation occurred at amino acid position 479 of the SARS-coronavirus-2 spike protein;

52) 사스-코로나바이러스-2의 스파이크 단백질의 481번 아미노산 위치에서 N481D 변이가 생긴 변이 바이러스;52) a mutant virus with N481D mutation at amino acid position 481 of the SARS-coronavirus-2 spike protein;

53) 사스-코로나바이러스-2의 스파이크 단백질의 482번 아미노산 위치에서 G482S 변이가 생긴 변이 바이러스;53) a mutant virus having a G482S mutation at amino acid position 482 of the SARS-coronavirus-2 spike protein;

54) 사스-코로나바이러스-2의 스파이크 단백질의 483번 아미노산 위치에서 V483A 변이 또는 V483I 변이가 생긴 변이 바이러스;54) a mutant virus having V483A mutation or V483I mutation at amino acid position 483 of the SARS-coronavirus-2 spike protein;

55) 사스-코로나바이러스-2의 스파이크 단백질의 484번 아미노산 위치에서 E484K 변이, E484G 변이 또는 E484Q 변이가 생긴 변이 바이러스;55) a mutant virus having E484K mutation, E484G mutation, or E484Q mutation at amino acid position 484 of the SARS-coronavirus-2 spike protein;

56) 사스-코로나바이러스-2의 스파이크 단백질의 485번 아미노산 위치에서 G485S변이가 생긴 변이 바이러스;56) a mutant virus in which a G485S mutation occurred at amino acid position 485 of the SARS-coronavirus-2 spike protein;

57) 사스-코로나바이러스-2의 스파이크 단백질의 486번 아미노산 위치에서 F486S 변이, F486L 변이, F486V 변이 또는 F486I 변이가 생긴 변이 바이러스;57) a mutant virus having F486S mutation, F486L mutation, F486V mutation or F486I mutation at amino acid position 486 of the SARS-coronavirus-2 spike protein;

58) 사스-코로나바이러스-2의 스파이크 단백질의 489번 아미노산 위치에서 Y489H 변이가 생긴 변이 바이러스;58) a mutant virus in which Y489H mutation occurred at amino acid position 489 of the SARS-coronavirus-2 spike protein;

59) 사스-코로나바이러스-2의 스파이크 단백질의 490번 아미노산 위치에서 F490S 변이가 생긴 변이 바이러스;59) a mutant virus having F490S mutation at amino acid position 490 of the SARS-coronavirus-2 spike protein;

60) 사스-코로나바이러스-2의 스파이크 단백질의 493번 아미노산 위치에서 Q493K 변이, Q493R 변이, Q493M 변이, Q493Y 변이 또는 Q493A 변이가 생긴 변이 바이러스;60) a mutant virus having Q493K mutation, Q493R mutation, Q493M mutation, Q493Y mutation or Q493A mutation at amino acid position 493 of the SARS-coronavirus-2 spike protein;

61) 사스-코로나바이러스-2의 스파이크 단백질의 494번 아미노산 위치에서 S494Q 변이, S494L 변이 또는 S494P 변이가 생긴 변이 바이러스;61) a mutant virus having S494Q mutation, S494L mutation, or S494P mutation at amino acid position 494 of the SARS-coronavirus-2 spike protein;

62) 사스-코로나바이러스-2의 스파이크 단백질의 498번 아미노산 위치에서 Q498H 변이가 생긴 변이 바이러스;62) a mutant virus having Q498H mutation at amino acid position 498 of the SARS-coronavirus-2 spike protein;

63) 사스-코로나바이러스-2의 스파이크 단백질의 499번 아미노산 위치에서 P499R 변이가 생긴 변이 바이러스;63) a mutant virus having P499R mutation at amino acid position 499 of the SARS-coronavirus-2 spike protein;

64) 사스-코로나바이러스-2의 스파이크 단백질의 501번 아미노산 위치에서 N501Y 변이, N501T 변이 또는 N501F 변이가 생긴 변이 바이러스;64) a mutant virus having N501Y mutation, N501T mutation or N501F mutation at amino acid position 501 of the SARS-coronavirus-2 spike protein;

65) 사스-코로나바이러스-2의 스파이크 단백질의 503번 아미노산 위치에서 V503F 변이가 생긴 변이 바이러스;65) a mutant virus having a V503F mutation at amino acid position 503 of the SARS-coronavirus-2 spike protein;

66) 사스-코로나바이러스-2의 스파이크 단백질의 505번 아미노산 위치에서 Y505C 변이가 생긴 변이 바이러스;66) a mutant virus in which Y505C mutation occurred at amino acid position 505 of the SARS-coronavirus-2 spike protein;

67) 사스-코로나바이러스-2의 스파이크 단백질의 508번 아미노산 위치에서 Y508H 변이가 생긴 변이 바이러스;67) a mutant virus with Y508H mutation at amino acid position 508 of the SARS-coronavirus-2 spike protein;

68) 사스-코로나바이러스-2의 스파이크 단백질의 520번 아미노산 위치에서 A520S 변이 또는 A520V 변이가 생긴 변이 바이러스;68) A mutant virus having A520S mutation or A520V mutation at amino acid position 520 of the SARS-coronavirus-2 spike protein;

69) 사스-코로나바이러스-2의 스파이크 단백질의 521번 아미노산 위치에서 P521R 변이 또는 P521S 변이가 생긴 변이 바이러스;69) a mutant virus having P521R mutation or P521S mutation at amino acid position 521 of the SARS-coronavirus-2 spike protein;

70) 사스-코로나바이러스-2의 스파이크 단백질의 522번 아미노산 위치에서 A522S 변이 또는 A522V 변이가 생긴 변이 바이러스;70) A mutant virus having A522S mutation or A522V mutation at amino acid position 522 of the SARS-coronavirus-2 spike protein;

71) 사스-코로나바이러스-2의 스파이크 단백질의 614번 아미노산 위치에서 D614G 변이가 생긴 변이 바이러스;71) a mutant virus having a D614G mutation at amino acid position 614 of the SARS-coronavirus-2 spike protein;

72) 사스-코로나바이러스-2의 스파이크 단백질의 677번 아미노산 위치에서 Q677H 변이가 생긴 변이 바이러스;72) a mutant virus having Q677H mutation at amino acid position 677 of the SARS-coronavirus-2 spike protein;

73) 사스-코로나바이러스-2의 스파이크 단백질의 681번 아미노산 위치에서 P681H 변이 또는 P681R 변이가 생긴 변이 바이러스;73) a mutant virus having P681H mutation or P681R mutation at amino acid position 681 of the SARS-coronavirus-2 spike protein;

74) 사스-코로나바이러스-2의 스파이크 단백질의 685번 아미노산 위치에서 R685H 변이가 생긴 변이 바이러스; 74) a mutant virus having R685H mutation at amino acid position 685 of the SARS-coronavirus-2 spike protein;

75) 사스-코로나바이러스-2의 스파이크 단백질의 701번 아미노산 위치에서 A701V 변이가 생긴 변이 바이러스;75) A mutant virus having A701V mutation at amino acid position 701 of the SARS-coronavirus-2 spike protein;

및and

76) 사스-코로나바이러스-2의 스파이크 단백질의 1176번 아미노산 위치에서 V1176F 변이가 생긴 변이 바이러스.76) A mutant virus with a V1176F mutation at amino acid position 1176 of the SARS-coronavirus-2 spike protein.

본 발명의 다른 측면에서, 본 발명은 본 발명에 따른 결합 분자에 추가적으로 하나 이상의 태그가 결합된 이뮤노컨쥬게이트(immunoconjugate)를 제공한다. 일 구체예에서, 상기 결합 분자에 약물이 추가로 부착될 수 있다. 본 발명에 있어, 본 발명에 따른 결합 분자는 약제가 결합된 항체-약물 접합체(conjugate)의 형태로 사용될 수 있다. 약물을 국소 전달하기 위해 항체-약물 접합체(ADC), 즉 면역접합체를 사용하게 되면 상기 약물 모이어티를 감염된 세포에 표적화 전달할 수 있는데, 상기 약물 작용제를 접합시키지 않은 채로 투여하게 되면, 정상 세포에 대해서도 허용될 수 없는 수준의 독성이 야기될 수 있기 때문이다. 약물-연결성 및 약물-방출성 뿐만 아니라 폴리클로날 및 모노클로날 항체(mAb)의 선택성을 높임으로써 ADC의 최대 효능과 최소 독성을 개선할 수 있다.In another aspect of the present invention, the present invention provides an immunoconjugate in which one or more tags are additionally bound to the binding molecule according to the present invention. In one embodiment, a drug may be further attached to the binding molecule. In the present invention, the binding molecule according to the present invention may be used in the form of an antibody-drug conjugate to which a drug is bound. The use of antibody-drug conjugates (ADCs), i.e., immunoconjugates, for local delivery of drugs allows for targeted delivery of the drug moiety to infected cells, which when administered unconjugated to normal cells as well. This is because unacceptable levels of toxicity can result. Maximal efficacy and minimal toxicity of ADCs can be improved by increasing drug-connectivity and drug-releasing properties, as well as selectivity of polyclonal and monoclonal antibodies (mAbs).

약물 모이어티를 항체에 부착시키는, 예를 들어 공유 결합을 통하여 연결시키는 통상적인 수단으로는, 일반적으로 약물 모이어티가 항체 상의 수많은 부위에 부착되는 불균질한 분자 혼합물이 유발된다. 예를 들어, 세포독성 약물을 전형적으로, 종종 항체의 수많은 리신 잔기를 통하여 항체와 접합시켜 불균질한 항체-약물 접합체 혼합물을 생성킬 수 있다. 반응 조건에 따라서, 이러한 불균질한 혼합물은 전형적으로, 약물 모이어티에 부착된 항체 분포도가 0 내지 약 8 이상이다. 또한, 특별한 정수 비의 약물 모이어티 대 항체를 수반한 접합체의 각 아군은, 약물 모이어티가 항체 상의 각종 부위에 부착되는 잠재적으로 불균질한 혼합물이다. 항체는 크고, 복잡하며 구조적으로 다양한 생체 분자이고, 종종 많은 반응성 관능기를 갖고 있다. 링커 시약 및 약물-링커 중간체와의 반응성은 pH, 농도, 염 농도 및 조용매와 같은 요인들에 의해 좌우된다.Conventional means of attaching drug moieties to antibodies, for example linking via covalent bonds, generally result in heterogeneous molecular mixtures in which drug moieties are attached to numerous sites on the antibody. For example, a cytotoxic drug can be conjugated with an antibody, typically through the numerous lysine residues of the antibody, resulting in a heterogeneous antibody-drug conjugate mixture. Depending on the reaction conditions, such heterogeneous mixtures typically have a distribution of 0 to about 8 or greater of antibody attached to the drug moiety. In addition, each subgroup of conjugates with a particular integer ratio of drug moieties to antibody is a potentially heterogeneous mixture in which drug moieties are attached to various sites on the antibody. Antibodies are large, complex and structurally diverse biomolecules, often with many reactive functional groups. Reactivity with linker reagents and drug-linker intermediates depends on factors such as pH, concentration, salt concentration and cosolvent.

본 발명의 다른 측면에서, 본 발명은 본 발명에 따른 결합 분자를 암호화하는 핵산 분자를 제공한다. 본 발명의 일 구체예에서, 본 발명의 핵산 분자는 본 발명에서 제공하는 항체의 아미노산 서열이 당업자에게 알려진 바와 같이 폴리뉴클레오티드 서열로 번역된 핵산 분자 모두를 포함한다. 그러므로 본 발명에 있어, ORF(open reading frame)에 의한 다양한 폴리뉴클레오티드 서열이 제조될 수 있으며, 이들은 본 발명의 핵산 분자에 포함될 수 있다.In another aspect of the invention, the invention provides a nucleic acid molecule encoding a binding molecule according to the invention. In one embodiment of the present invention, the nucleic acid molecule of the present invention includes all nucleic acid molecules in which the amino acid sequence of the antibody provided in the present invention is translated into a polynucleotide sequence as known to those skilled in the art. Therefore, in the present invention, various polynucleotide sequences can be prepared by an open reading frame (ORF), and these can be included in the nucleic acid molecule of the present invention.

본 발명의 다른 측면에서, 본 발명은 본 발명에 따른 핵산 분자가 삽입된 발현 벡터를 제공한다. 본 발명에 있어, 상기 발현 벡터로는 셀트리온 고유의 발현 벡터인 MarEx 벡터(한국등록특허 제10-1076602호 참조) 및 상업적으로 널리 사용되는 pCDNA 벡터, F, R1, RP1, Col, pBR322, ToL, Ti 벡터; 코스미드; 람다, 람도이드(lambdoid), M13, Mu, p1 P22, Qμ, T-even, T2, T3, T7 등의 파아지; 및 식물 바이러스로 이루어진 군으로부터 선택된 어느 하나에서 선택된 발현 벡터를 이용할 수 있으나 이에 한정되지 않는다. 본 발명에 있어, 당업자에게 발현 벡터로 알려진 모든 발현 벡터는 본 발명에 사용 가능하며, 발현 벡터의 선택은 목적으로 하는 숙주 세포의 성질에 따른다. 본 발명에 있어, 숙주세포로의 벡터 도입은 인산칼슘 트랜스펙션, 바이러스 감염, DEAE-덱스트란 조절 트랜스펙션, 리포펙타민 트랜스펙션 또는 전기천공법에 의해 수행될 수 있으나 이에 한정되지 않으며, 당업자는 사용하는 발현 벡터 및 숙주 세포에 알맞은 도입 방법을 선택하여 이용할 수 있다. 예를 들어, 본 발명에 따른 벡터는 하나 이상의 선별 마커를 함유하나 이에 한정되지 않으며, 선별 마커를 포함하지 않은 벡터도 이용하여 생산물 생산 여부에 따라 선별이 가능하다. 본 발명의 일 구체예에서, 상기 선별 마커의 선택은 목적하는 숙주 세포에 의해 선택되며, 이는 이미 당업자에게 알려진 방법을 이용하므로 본 발명은 이에 제한을 두지 않는다. In another aspect of the present invention, the present invention provides an expression vector into which a nucleic acid molecule according to the present invention is inserted. In the present invention, as the expression vector, Celltrion's own expression vector, MarEx vector (refer to Korean Patent No. 10-1076602) and commercially widely used pCDNA vectors, F, R1, RP1, Col, pBR322, ToL, Ti vector; cosmid; phage such as lambda, lambdoid, M13, Mu, p1 P22, Qμ, T-even, T2, T3, T7; and an expression vector selected from any one selected from the group consisting of plant viruses, but is not limited thereto. In the present invention, any expression vector known to those skilled in the art as an expression vector can be used in the present invention, and selection of the expression vector depends on the properties of the target host cell. In the present invention, the vector introduction into the host cell may be performed by calcium phosphate transfection, virus infection, DEAE-dextran controlled transfection, lipofectamine transfection or electroporation, but is not limited thereto. , a person skilled in the art can select and use an introduction method suitable for the expression vector and host cell to be used. For example, the vector according to the present invention contains one or more selectable markers, but is not limited thereto, and a vector that does not contain a selectable marker may be used to select depending on whether a product is produced. In one embodiment of the present invention, the selection of the selection marker is selected by a desired host cell, which uses a method already known to those skilled in the art, so the present invention is not limited thereto.

본 발명에 있어, 본 발명의 결합 분자의 정제를 용이하게 하기 위하여 태그 (또는 태그 서열)을 발현 벡터 상에 삽입하여 융합시킬 수 있다. 본 발명의 일 구체예에 있어, 상기 태그로는 헥사-히스티딘 태그, 헤마글루티닌 태그, myc 태그 또는 flag 태그를 포함하나 이에 한정되지 않으며, 당업자에게 알려진 정제를 용이하게 하는 태그는 모두 본 발명에서 이용 가능하다. In the present invention, in order to facilitate purification of the binding molecule of the present invention, a tag (or tag sequence) may be inserted into an expression vector and fused. In one embodiment of the present invention, the tag includes, but is not limited to, a hexa-histidine tag, a hemagglutinin tag, a myc tag, or a flag tag, and any tag facilitating purification known to those skilled in the art is the present invention available in

본 발명의 다른 측면에서, 본 발명은 본 발명에 따른 발현 벡터로 형질전환된 세포주를 제공한다. 본 발명의 일 구체예에서, 상기 발현 벡터가 숙주 세포에 형질전환되어, SARS-CoV-2에 결합하여 중화 능력을 가지는 결합 분자를 생산하는 세포주를 제공한다. 본 발명에 있어서, 상기 세포주는 CHO 세포, F2N 세포, COS 세포, BHK 세포, 바우스(Bowes) 흑색종 세포, HeLa 세포, 911 세포, HT1080 세포, A549 세포, HEK 293 세포 및 HEK293T 세포로 이루어진 군으로부터 선택된 어느 하나일 수 있으나, 이에 한정되는 것은 아니며, 당업자에게 알려진 포유동물 숙주세포로 사용 가능한 세포는 모두 이용 가능하다.In another aspect of the present invention, the present invention provides a cell line transformed with the expression vector according to the present invention. In one embodiment of the present invention, the expression vector is transformed into a host cell to provide a cell line producing a binding molecule having neutralizing ability by binding to SARS-CoV-2. In the present invention, the cell line is selected from the group consisting of CHO cells, F2N cells, COS cells, BHK cells, Bowes melanoma cells, HeLa cells, 911 cells, HT1080 cells, A549 cells, HEK 293 cells and HEK293T cells. It may be any one selected, but is not limited thereto, and any cell that can be used as a mammalian host cell known to those skilled in the art can be used.

본 발명의 다른 측면에서, 본 발명은 본 발명에 따른 결합 분자를 포함하는 사스-코로나바이러스 감염증(COVID-19)의 진단, 예방 또는 치료용 조성물을 제공한다. 본 발명에 있어, 본 발명의 조성물은 상기 결합 분자 이외에 약제학적으로 허용 가능한 부형제를 포함할 수 있다. 본 발명의 일 구체예에서, 상기 약제학적으로 허용 가능한 부형제는 당업자에게 이미 잘 알려져 있는 부형제다. In another aspect of the present invention, the present invention provides a composition for diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19) comprising the binding molecule according to the present invention. In the present invention, the composition of the present invention may include a pharmaceutically acceptable excipient in addition to the binding molecule. In one embodiment of the present invention, the pharmaceutically acceptable excipient is an excipient well known to those skilled in the art.

본 발명의 사스-코로나바이러스 감염증(COVID-19)의 진단, 예방 또는 치료용 조성물은, 상기 결합 분자에 대한 설명이 그대로 적용된다. For the composition for diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19) of the present invention, the description of the binding molecule is applied as it is.

본 발명의 일 구체예에 있어, 본 발명의 사스-코로나바이러스 감염증(COVID-19)의 진단, 예방 또는 치료용 조성물은, 본 발명에 따른 결합 분자를 포함하는 것으로, 사스-코로나바이러스-2의 스파이크 단백질에 돌연변이가 생긴 변이 바이러스에 중화능이 있다. 또한, 본 발명의 일 구체예에 있어, 본 발명의 사스-코로나바이러스 감염증(COVID-19)의 진단, 예방 또는 치료용 조성물은, 사스-코로나바이러스-2의 스파이크 단백질의 RBD 영역 이외의 부위에 돌연변이가 생긴 변이 바이러스에 중화능이 있는 것을 포함하며, 사스-코로나바이러스-2 S형, L형, V형, G형, GH형 또는 GR형에 중화능이 있는 것을 포함한다. In one embodiment of the present invention, the composition for diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19) of the present invention comprises the binding molecule according to the present invention, and SARS-coronavirus-2 A mutant virus with a mutation in the spike protein has neutralizing ability. In addition, in one embodiment of the present invention, the composition for diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19) of the present invention is located in a region other than the RBD region of the SARS-coronavirus-2 spike protein. Including those having the ability to neutralize the mutated virus, SARS-Coronavirus-2 includes those having neutralizing ability to S type, L type, V type, G type, GH type or GR type.

본 발명에 있어, 본 발명의 사스-코로나바이러스 감염증(COVID-19)의 진단, 예방 또는 치료용 조성물은, 하기 1) 내지 76)으로 이루어진 군으로부터 선택되는 어느 하나 이상의 변이 바이러스를 중화하기 위한 것일 수 있다:In the present invention, the composition for diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19) of the present invention is to neutralize any one or more mutated viruses selected from the group consisting of the following 1) to 76) can:

1) 사스-코로나바이러스-2의 스파이크 단백질의 69번 및 70번 아미노산 위치 중 하나 이상이 결실된 변이 바이러스;One) a mutant virus in which at least one of amino acid positions 69 and 70 of the SARS-coronavirus-2 spike protein is deleted;

2) 사스-코로나바이러스-2의 스파이크 단백질의 80번 아미노산 위치에서 D80A 변이가 생긴 변이 바이러스;2) a mutant virus having a D80A mutation at amino acid position 80 of the SARS-coronavirus-2 spike protein;

3) 사스-코로나바이러스-2의 스파이크 단백질의 222번 아미노산 위치에서 A222V 변이가 생긴 변이 바이러스;3) A mutant virus with A222V mutation at amino acid position 222 of the SARS-coronavirus-2 spike protein;

4) 사스-코로나바이러스-2의 스파이크 단백질의 234번 아미노산 위치에서 N234Q 변이가 생긴 변이 바이러스;4) a mutant virus having N234Q mutation at amino acid position 234 of the SARS-coronavirus-2 spike protein;

5) 사스-코로나바이러스-2의 스파이크 단백질의 337번 아미노산 위치에서 P337S 변이가 생긴 변이 바이러스;5) a mutant virus in which a P337S mutation occurred at amino acid position 337 of the SARS-coronavirus-2 spike protein;

6) 사스-코로나바이러스-2의 스파이크 단백질의 338번 아미노산 위치에서 F338L 변이가 생긴 변이 바이러스;6) a mutant virus having F338L mutation at amino acid position 338 of the SARS-coronavirus-2 spike protein;

7) 사스-코로나바이러스-2의 스파이크 단백질의 348번 아미노산 위치에서 A348S 변이가 생긴 변이 바이러스;7) A mutant virus having an A348S mutation at amino acid position 348 of the SARS-coronavirus-2 spike protein;

8) 사스-코로나바이러스-2의 스파이크 단백질의 367번 아미노산 위치에서 V367F 변이가 생긴 변이 바이러스;8) a mutant virus having a V367F mutation at amino acid position 367 of the SARS-coronavirus-2 spike protein;

9) 사스-코로나바이러스-2의 스파이크 단백질의 370번 아미노산 위치에서 N370S 변이가 생긴 변이 바이러스;9) a mutant virus with N370S mutation at amino acid position 370 of the SARS-coronavirus-2 spike protein;

10) 사스-코로나바이러스-2의 스파이크 단백질의 372번 아미노산 위치에서 A372S 변이, A372T 변이 또는 A372V 변이가 생긴 변이 바이러스;10) A mutant virus having A372S mutation, A372T mutation, or A372V mutation at amino acid position 372 of the SARS-coronavirus-2 spike protein;

11) 사스-코로나바이러스-2의 스파이크 단백질의 341번 아미노산 위치에서 V341I 변이가 생긴 변이 바이러스;11) a mutant virus in which V341I mutation occurred at amino acid position 341 of the SARS-coronavirus-2 spike protein;

12) 사스-코로나바이러스-2의 스파이크 단백질의 342번 아미노산 위치에서 F342L 변이가 생긴 변이 바이러스;12) a mutant virus having F342L mutation at amino acid position 342 of the SARS-coronavirus-2 spike protein;

13) 사스-코로나바이러스-2의 스파이크 단백질의 344번 아미노산 위치에서 A344S 변이가 생긴 변이 바이러스;13) A mutant virus having an A344S mutation at amino acid position 344 of the SARS-coronavirus-2 spike protein;

14) 사스-코로나바이러스-2의 스파이크 단백질의 352번 아미노산 위치에서 A352S 변이가 생긴 변이 바이러스;14) A mutant virus in which A352S mutation occurred at amino acid position 352 of the SARS-coronavirus-2 spike protein;

15) 사스-코로나바이러스-2의 스파이크 단백질의 354번 아미노산 위치에서 N354D 변이가 생긴 변이 바이러스;15) a mutant virus with N354D mutation at amino acid position 354 of the SARS-coronavirus-2 spike protein;

16) 사스-코로나바이러스-2의 스파이크 단백질의 359번 아미노산 위치에서 S359N 변이가 생긴 변이 바이러스;16) a mutant virus having S359N mutation at amino acid position 359 of the SARS-coronavirus-2 spike protein;

17) 사스-코로나바이러스-2의 스파이크 단백질의 377번 아미노산 위치에서 F377L 변이가 생긴 변이 바이러스;17) a mutant virus having F377L mutation at amino acid position 377 of the SARS-coronavirus-2 spike protein;

18) 사스-코로나바이러스-2의 스파이크 단백질의 378번 아미노산 위치에서 K378R 변이 또는 K378N 변이가 생긴 변이 바이러스;18) a mutant virus having K378R mutation or K378N mutation at amino acid position 378 of the SARS-coronavirus-2 spike protein;

19) 사스-코로나바이러스-2의 스파이크 단백질의 384번 아미노산 위치에서 P384L 변이가 생긴 변이 바이러스;19) a mutant virus in which P384L mutation occurred at amino acid position 384 of the SARS-coronavirus-2 spike protein;

20) 사스-코로나바이러스-2의 스파이크 단백질의 385번 아미노산 위치에서 T385A 변이가 생긴 변이 바이러스;20) a mutant virus having T385A mutation at amino acid position 385 of the SARS-coronavirus-2 spike protein;

21) 사스-코로나바이러스-2의 스파이크 단백질의 393번 아미노산 위치에서 T393P 변이가 생긴 변이 바이러스;21) a mutant virus having T393P mutation at amino acid position 393 of the SARS-coronavirus-2 spike protein;

22) 사스-코로나바이러스-2의 스파이크 단백질의 395번 아미노산 위치에서 V395I 변이가 생긴 변이 바이러스;22) a mutant virus in which the V395I mutation occurred at amino acid position 395 of the SARS-coronavirus-2 spike protein;

23) 사스-코로나바이러스-2의 스파이크 단백질의 405번 아미노산 위치에서 D405V 변이가 생긴 변이 바이러스;23) a mutant virus having a D405V mutation at amino acid position 405 of the SARS-coronavirus-2 spike protein;

24) 사스-코로나바이러스-2의 스파이크 단백질의 406번 아미노산 위치에서 E406Q 변이 또는 E406W 변이가 생긴 변이 바이러스;24) a mutant virus having E406Q mutation or E406W mutation at amino acid position 406 of the SARS-coronavirus-2 spike protein;

25) 사스-코로나바이러스-2의 스파이크 단백질의 408번 아미노산 위치에서 R408I 변이가 생긴 변이 바이러스;25) a mutant virus having R408I mutation at amino acid position 408 of the SARS-coronavirus-2 spike protein;

26) 사스-코로나바이러스-2의 스파이크 단백질의 409번 아미노산 위치에서 Q409E 변이가 생긴 변이 바이러스;26) a mutant virus having Q409E mutation at amino acid position 409 of the SARS-coronavirus-2 spike protein;

27) 사스-코로나바이러스-2의 스파이크 단백질의 414번 아미노산 위치에서 Q414A 변이, Q414E 변이 또는 Q414R 변이가 생긴 변이 바이러스;27) a mutant virus having Q414A mutation, Q414E mutation, or Q414R mutation at amino acid position 414 of the SARS-coronavirus-2 spike protein;

28) 사스-코로나바이러스-2의 스파이크 단백질의 417번 아미노산 위치에서 K417N 변이, K417T 변이 또는 K417E 변이가 생긴 변이 바이러스;28) a mutant virus having K417N mutation, K417T mutation or K417E mutation at amino acid position 417 of the SARS-coronavirus-2 spike protein;

29) 사스-코로나바이러스-2의 스파이크 단백질의 420번 아미노산 위치에서 D420N 변이가 생긴 변이 바이러스;29) a mutant virus with a D420N mutation at amino acid position 420 of the SARS-coronavirus-2 spike protein;

30) 사스-코로나바이러스-2의 스파이크 단백질의 435번 아미노산 위치에서 A435S 변이가 생긴 변이 바이러스;30) A mutant virus having an A435S mutation at amino acid position 435 of the SARS-coronavirus-2 spike protein;

31) 사스-코로나바이러스-2의 스파이크 단백질의 436번 아미노산 위치에서 W436R 변이가 생긴 변이 바이러스;31) a mutant virus having a W436R mutation at amino acid position 436 of the SARS-coronavirus-2 spike protein;

32) 사스-코로나바이러스-2의 스파이크 단백질의 439번 아미노산 위치에서 N439K 변이가 생긴 변이 바이러스;32) a mutant virus having N439K mutation at amino acid position 439 of the SARS-coronavirus-2 spike protein;

33) 사스-코로나바이러스-2의 스파이크 단백질의 440번 아미노산 위치에서 N440K 변이 또는 N440D 변이가 생긴 변이 바이러스;33) a mutant virus having N440K mutation or N440D mutation at amino acid position 440 of the SARS-coronavirus-2 spike protein;

34) 사스-코로나바이러스-2의 스파이크 단백질의 444번 아미노산 위치에서 K444Q 변이 또는 K444R 변이가 생긴 변이 바이러스;34) a mutant virus in which K444Q mutation or K444R mutation occurs at amino acid position 444 of the SARS-coronavirus-2 spike protein;

35) 사스-코로나바이러스-2의 스파이크 단백질의 445번 아미노산 위치에서 V445A 변이 또는 V445F 변이가 생긴 변이 바이러스;35) a mutant virus having V445A mutation or V445F mutation at amino acid position 445 of the SARS-coronavirus-2 spike protein;

36) 사스-코로나바이러스-2의 스파이크 단백질의 446번 아미노산 위치에서 G446V 변이 또는 G446S 변이가 생긴 변이 바이러스;36) a mutant virus having a G446V mutation or a G446S mutation at amino acid position 446 of the SARS-coronavirus-2 spike protein;

37) 사스-코로나바이러스-2의 스파이크 단백질의 449번 아미노산 위치에서 Y449N 변이가 생긴 변이 바이러스;37) a mutant virus in which Y449N mutation occurs at amino acid position 449 of the SARS-coronavirus-2 spike protein;

38) 사스-코로나바이러스-2의 스파이크 단백질의 452번 아미노산 위치에서 L452R 변이가 생긴 변이 바이러스;38) a mutant virus having L452R mutation at amino acid position 452 of the SARS-coronavirus-2 spike protein;

39) 사스-코로나바이러스-2의 스파이크 단백질의 453번 아미노산 위치에서 Y453F 변이가 생긴 변이 바이러스;39) a mutant virus having a Y453F mutation at amino acid position 453 of the SARS-coronavirus-2 spike protein;

40) 사스-코로나바이러스-2의 스파이크 단백질의 455번 아미노산 위치에서 L455F 변이가 생긴 변이 바이러스;40) a mutant virus having L455F mutation at amino acid position 455 of the SARS-coronavirus-2 spike protein;

41) 사스-코로나바이러스-2의 스파이크 단백질의 456번 아미노산 위치에서 F456L 변이 또는 F456E 변이가 생긴 변이 바이러스;41) a mutant virus having F456L mutation or F456E mutation at amino acid position 456 of the SARS-coronavirus-2 spike protein;

42) 사스-코로나바이러스-2의 스파이크 단백질의 458번 아미노산 위치에서 K458R 변이 또는 K458Q 변이가 생긴 변이 바이러스;42) a mutant virus having K458R mutation or K458Q mutation at amino acid position 458 of the SARS-coronavirus-2 spike protein;

43) 사스-코로나바이러스-2의 스파이크 단백질의 460번 아미노산 위치에서 N460T 변이가 생긴 변이 바이러스;43) a mutant virus in which N460T mutation occurred at amino acid position 460 of the SARS-coronavirus-2 spike protein;

44) 사스-코로나바이러스-2의 스파이크 단백질의 471번 아미노산 위치에서 E471Q 변이가 생긴 변이 바이러스;44) a mutant virus having E471Q mutation at amino acid position 471 of the SARS-coronavirus-2 spike protein;

45) 사스-코로나바이러스-2의 스파이크 단백질의 472번 아미노산 위치에서 I472V 변이가 생긴 변이 바이러스;45) A mutant virus with I472V mutation at amino acid position 472 of the SARS-coronavirus-2 spike protein;

46) 사스-코로나바이러스-2의 스파이크 단백질의 473번 아미노산 위치에서 Y473F 변이가 생긴 변이 바이러스;46) a mutant virus in which Y473F mutation occurred at amino acid position 473 of the SARS-coronavirus-2 spike protein;

47) 사스-코로나바이러스-2의 스파이크 단백질의 475번 아미노산 위치에서 A475V 변이가 생긴 변이 바이러스;47) A mutant virus having A475V mutation at amino acid position 475 of the SARS-coronavirus-2 spike protein;

48) 사스-코로나바이러스-2의 스파이크 단백질의 476번 아미노산 위치에서 G476S 변이가 생긴 변이 바이러스;48) a mutant virus having a G476S mutation at amino acid position 476 of the SARS-coronavirus-2 spike protein;

49) 사스-코로나바이러스-2의 스파이크 단백질의 477번 아미노산 위치에서 S477N 변이, S477R 변이, S477I 변이 또는 S477R 변이가 생긴 변이 바이러스;49) a mutant virus having S477N mutation, S477R mutation, S477I mutation or S477R mutation at amino acid position 477 of the SARS-coronavirus-2 spike protein;

50) 사스-코로나바이러스-2의 스파이크 단백질의 478번 아미노산 위치에서 T478K 변이 또는 T478I 변이가 생긴 변이 바이러스;50) a mutant virus having T478K mutation or T478I mutation at amino acid position 478 of the SARS-coronavirus-2 spike protein;

51) 사스-코로나바이러스-2의 스파이크 단백질의 479번 아미노산 위치에서 P479S 변이가 생긴 변이 바이러스;51) a mutant virus in which a P479S mutation occurred at amino acid position 479 of the SARS-coronavirus-2 spike protein;

52) 사스-코로나바이러스-2의 스파이크 단백질의 481번 아미노산 위치에서 N481D 변이가 생긴 변이 바이러스;52) a mutant virus with N481D mutation at amino acid position 481 of the SARS-coronavirus-2 spike protein;

53) 사스-코로나바이러스-2의 스파이크 단백질의 482번 아미노산 위치에서 G482S 변이가 생긴 변이 바이러스;53) a mutant virus having a G482S mutation at amino acid position 482 of the SARS-coronavirus-2 spike protein;

54) 사스-코로나바이러스-2의 스파이크 단백질의 483번 아미노산 위치에서 V483A 변이 또는 V483I 변이가 생긴 변이 바이러스;54) a mutant virus having V483A mutation or V483I mutation at amino acid position 483 of the SARS-coronavirus-2 spike protein;

55) 사스-코로나바이러스-2의 스파이크 단백질의 484번 아미노산 위치에서 E484K 변이, E484G 변이 또는 E484Q 변이가 생긴 변이 바이러스;55) a mutant virus having E484K mutation, E484G mutation, or E484Q mutation at amino acid position 484 of the SARS-coronavirus-2 spike protein;

56) 사스-코로나바이러스-2의 스파이크 단백질의 485번 아미노산 위치에서 G485S변이가 생긴 변이 바이러스;56) a mutant virus in which a G485S mutation occurred at amino acid position 485 of the SARS-coronavirus-2 spike protein;

57) 사스-코로나바이러스-2의 스파이크 단백질의 486번 아미노산 위치에서 F486S 변이, F486L 변이, F486V 변이 또는 F486I 변이가 생긴 변이 바이러스;57) a mutant virus having F486S mutation, F486L mutation, F486V mutation or F486I mutation at amino acid position 486 of the SARS-coronavirus-2 spike protein;

58) 사스-코로나바이러스-2의 스파이크 단백질의 489번 아미노산 위치에서 Y489H 변이가 생긴 변이 바이러스;58) a mutant virus in which Y489H mutation occurred at amino acid position 489 of the SARS-coronavirus-2 spike protein;

59) 사스-코로나바이러스-2의 스파이크 단백질의 490번 아미노산 위치에서 F490S 변이가 생긴 변이 바이러스;59) a mutant virus having F490S mutation at amino acid position 490 of the SARS-coronavirus-2 spike protein;

60) 사스-코로나바이러스-2의 스파이크 단백질의 493번 아미노산 위치에서 Q493K 변이, Q493R 변이, Q493M 변이, Q493Y 변이 또는 Q493A 변이가 생긴 변이 바이러스;60) a mutant virus having Q493K mutation, Q493R mutation, Q493M mutation, Q493Y mutation or Q493A mutation at amino acid position 493 of the SARS-coronavirus-2 spike protein;

61) 사스-코로나바이러스-2의 스파이크 단백질의 494번 아미노산 위치에서 S494Q 변이, S494L 변이 또는 S494P 변이가 생긴 변이 바이러스;61) a mutant virus having S494Q mutation, S494L mutation, or S494P mutation at amino acid position 494 of the SARS-coronavirus-2 spike protein;

62) 사스-코로나바이러스-2의 스파이크 단백질의 498번 아미노산 위치에서 Q498H 변이가 생긴 변이 바이러스;62) a mutant virus having Q498H mutation at amino acid position 498 of the SARS-coronavirus-2 spike protein;

63) 사스-코로나바이러스-2의 스파이크 단백질의 499번 아미노산 위치에서 P499R 변이가 생긴 변이 바이러스;63) a mutant virus having P499R mutation at amino acid position 499 of the SARS-coronavirus-2 spike protein;

64) 사스-코로나바이러스-2의 스파이크 단백질의 501번 아미노산 위치에서 N501Y 변이, N501T 변이 또는 N501F 변이가 생긴 변이 바이러스;64) a mutant virus having N501Y mutation, N501T mutation or N501F mutation at amino acid position 501 of the SARS-coronavirus-2 spike protein;

65) 사스-코로나바이러스-2의 스파이크 단백질의 503번 아미노산 위치에서 V503F 변이가 생긴 변이 바이러스;65) a mutant virus having a V503F mutation at amino acid position 503 of the SARS-coronavirus-2 spike protein;

66) 사스-코로나바이러스-2의 스파이크 단백질의 505번 아미노산 위치에서 Y505C 변이가 생긴 변이 바이러스;66) a mutant virus in which Y505C mutation occurred at amino acid position 505 of the SARS-coronavirus-2 spike protein;

67) 사스-코로나바이러스-2의 스파이크 단백질의 508번 아미노산 위치에서 Y508H 변이가 생긴 변이 바이러스;67) a mutant virus with Y508H mutation at amino acid position 508 of the SARS-coronavirus-2 spike protein;

68) 사스-코로나바이러스-2의 스파이크 단백질의 520번 아미노산 위치에서 A520S 변이 또는 A520V 변이가 생긴 변이 바이러스;68) A mutant virus having A520S mutation or A520V mutation at amino acid position 520 of the SARS-coronavirus-2 spike protein;

69) 사스-코로나바이러스-2의 스파이크 단백질의 521번 아미노산 위치에서 P521R 변이 또는 P521S 변이가 생긴 변이 바이러스;69) a mutant virus having P521R mutation or P521S mutation at amino acid position 521 of the SARS-coronavirus-2 spike protein;

70) 사스-코로나바이러스-2의 스파이크 단백질의 522번 아미노산 위치에서 A522S 변이 또는 A522V 변이가 생긴 변이 바이러스;70) A mutant virus having A522S mutation or A522V mutation at amino acid position 522 of the SARS-coronavirus-2 spike protein;

71) 사스-코로나바이러스-2의 스파이크 단백질의 614번 아미노산 위치에서 D614G 변이가 생긴 변이 바이러스;71) a mutant virus having a D614G mutation at amino acid position 614 of the SARS-coronavirus-2 spike protein;

72) 사스-코로나바이러스-2의 스파이크 단백질의 677번 아미노산 위치에서 Q677H 변이가 생긴 변이 바이러스;72) a mutant virus having Q677H mutation at amino acid position 677 of the SARS-coronavirus-2 spike protein;

73) 사스-코로나바이러스-2의 스파이크 단백질의 681번 아미노산 위치에서 P681H 변이 또는 P681R 변이가 생긴 변이 바이러스;73) a mutant virus having P681H mutation or P681R mutation at amino acid position 681 of the SARS-coronavirus-2 spike protein;

74) 사스-코로나바이러스-2의 스파이크 단백질의 685번 아미노산 위치에서 R685H 변이가 생긴 변이 바이러스; 74) a mutant virus having R685H mutation at amino acid position 685 of the SARS-coronavirus-2 spike protein;

75) 사스-코로나바이러스-2의 스파이크 단백질의 701번 아미노산 위치에서 A701V 변이가 생긴 변이 바이러스;75) A mutant virus having A701V mutation at amino acid position 701 of the SARS-coronavirus-2 spike protein;

및and

76) 사스-코로나바이러스-2의 스파이크 단백질의 1176번 아미노산 위치에서 V1176F 변이가 생긴 변이 바이러스.76) A mutant virus with a V1176F mutation at amino acid position 1176 of the SARS-coronavirus-2 spike protein.

본 발명의 일 구체예에서, 본 발명에 따른 사스-코로나바이러스 감염증(COVID-19)의 진단, 예방 또는 치료용 조성물은 사스-코로나바이러스-2(SARS-CoV-2), 바람직하게는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질, 더욱 바람직하게는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질의 RBD(Receptor Binding Domain)와 표적 세포의 ACE2(Angiotensin-converting enzyme 2) 수용체의 결합을 억제하기 위한 것일 수 있다. In one embodiment of the present invention, the composition for diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19) according to the present invention is SARS-coronavirus-2 (SARS-CoV-2), preferably SARS- A spike protein of coronavirus-2 (SARS-CoV-2), more preferably, RBD (Receptor Binding Domain) of a spike protein of SARS-coronavirus-2 (SARS-CoV-2) and ACE2 (Angiotensin- converting enzyme 2) It may be to inhibit the binding of the receptor.

본 발명의 일 구체예에서, 본 발명에 따른 사스-코로나바이러스 감염증(COVID-19)의 진단, 예방 또는 치료용 조성물은 사스-코로나바이러스-2(SARS-CoV-2), 바람직하게는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질, 더욱 바람직하게는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질의 RBD(Receptor Binding Domain)의 결합에 표 1의 결합 분자로 이루어진 군으로부터 선택되는 어느 하나의 결합 분자와 경쟁하기 위한 것일 수 있다. 본 발명의 일 구체예에서, 본 발명에 따른 사스-코로나바이러스 감염증(COVID-19)의 진단, 예방 또는 치료용 조성물은, 사스-코로나바이러스-2의 스파이크 단백질의 RBD의 결합에 표 2의 결합 분자로 이루어진 군으로부터 선택되는 어느 하나의 결합 분자와 경쟁하기 위한 것일 수 있다. In one embodiment of the present invention, the composition for diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19) according to the present invention is SARS-coronavirus-2 (SARS-CoV-2), preferably SARS- The binding molecules of Table 1 to the binding of the spike protein of coronavirus-2 (SARS-CoV-2), more preferably the receptor binding domain (RBD) of the spike protein of SARS-coronavirus-2 (SARS-CoV-2). It may be for competition with any one binding molecule selected from the group consisting of. In one embodiment of the present invention, the composition for diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19) according to the present invention is the binding of Table 2 to the RBD binding of the SARS-coronavirus-2 spike protein It may be for competition with any one binding molecule selected from the group consisting of molecules.

본 발명에 있어, 본 발명의 조성물은 추가로 적어도 하나의 다른 치료제 또는 진단제를 포함할 수 있다. 예를 들어, 본 발명에 따른 결합 분자와 함께 사스-코로나바이러스-2(SARS-CoV-2) 표면의 N 단백질(Nucleocapsid protein, N protein)에 결합하는 결합 분자를 추가로 포함할 수 있다. 예를 들어, 상기 결합 분자와 함께 인터페론, 항-S 단백질 단일클론 항체, 항-S 단백질 폴리클로날 항체, 뉴클레오시드 유사체, DNA 폴리머라제 저해제, siRNA 제제 또는 치료백신을 항바이러스 약물로써 추가로 포함할 수 있다.In the present invention, the composition of the present invention may further include at least one other therapeutic agent or diagnostic agent. For example, together with the binding molecule according to the present invention, a binding molecule that binds to a nucleocapsid protein (N protein) on the surface of SARS-CoV-2 may be further included. For example, interferon, anti-S protein monoclonal antibody, anti-S protein polyclonal antibody, nucleoside analog, DNA polymerase inhibitor, siRNA agent, or therapeutic vaccine as an antiviral drug together with the binding molecule may include

본 발명에 있어, 본 발명의 결합 분자를 포함하는 조성물은, 각각 통상의 방법에 따라 멸균 주사용액, 동결건조(lyophilized) 제형, 사전 충전식 주사(pre-filled syringe) 용액제, 경구형 제형, 외용제 또는 좌제 등의 형태로 제형화할 수 있으나, 이에 한정되지 않는다. In the present invention, the composition comprising the binding molecule of the present invention is a sterile injection solution, a lyophilized formulation, a pre-filled syringe solution, an oral formulation, and an external formulation according to a conventional method, respectively. Or it may be formulated in the form of a suppository, etc., but is not limited thereto.

본 발명에 있어, 본 발명의 조성물을 인간을 포함하는 포유동물에게 투여함으로써 SARS-CoV-2 감염 또는 SARS-CoV-2 감염에 의해 유발되는 질병을 예방 또는 치료할 수 있다. 이때, 본 발명에 따른 결합 분자(예, 항체)의 투여량은 처리되는 대상, 질병 또는 상태의 심각도, 투여의 속도 및 처방 의사의 판단에 따른다. In the present invention, by administering the composition of the present invention to mammals including humans, it is possible to prevent or treat SARS-CoV-2 infection or diseases caused by SARS-CoV-2 infection. In this case, the dosage of the binding molecule (eg, antibody) according to the present invention depends on the subject to be treated, the severity of the disease or condition, the rate of administration, and the judgment of the prescribing physician.

또한, 본 발명의 다른 일 구체예에서, 본 발명은 사스-코로나바이러스-2(SARS-CoV-2) 표면의 스파이크 단백질(Spike protein, S protein)에 결합하는 결합 분자를 포함하는 면역크로마토그래피 분석용 스트립을 제공한다. 본 발명에 있어, 상기 면역크로마토그래피 분석용 스트립은 코로나바이러스의 뉴클레오캡시드 단백질(Nucleocapsid protein, N protein)에 결합하는 결합 분자를 추가로 포함할 수 있다. 본 발명에 있어, 상기 코로나바이러스는 사스-코로나바이러스-2(SARS-CoV-2), 인간 코로나바이러스 229E (HCoV-229E), 인간 코로나바이러스 OC43 (HCoV-OC43), 중증급성호흡기증후군 코로나바이러스 (SARS-CoV), 인간 코로나바이러스 NL63 (HCoV-NL63), 인간 코로나바이러스 HKU1 및 중동호흡기증후군 코로나바이러스 (MERS-CoV)로 구성된 군으로부터 선택된 어느 하나일 수 있으나, 이에 한정되는 것은 아니다. Further, in another embodiment of the present invention, the present invention is SARS-coronavirus-2 (SARS-CoV-2) immunochromatographic analysis comprising a binding molecule that binds to the spike protein (S protein) on the surface strips are provided. In the present invention, the strip for immunochromatographic analysis may further include a binding molecule that binds to the nucleocapsid protein (N protein) of the coronavirus. In the present invention, the coronavirus is SARS-coronavirus-2 (SARS-CoV-2), human coronavirus 229E (HCoV-229E), human coronavirus OC43 (HCoV-OC43), severe acute respiratory syndrome coronavirus ( SARS-CoV), human coronavirus NL63 (HCoV-NL63), human coronavirus HKU1, and may be any one selected from the group consisting of Middle East respiratory syndrome coronavirus (MERS-CoV), but is not limited thereto.

본 발명에 있어, 상기 면역크로마토그래피 분석용 스트립은 i) 지지체; ii) 검체 패드; iii) 컨쥬게이트 패드; iv) 신호 검출 패드; 및 v) 흡수 패드를 포함할 수 있다.In the present invention, the strip for immunochromatographic analysis includes: i) a support; ii) a specimen pad; iii) a conjugate pad; iv) a signal detection pad; and v) an absorbent pad.

바람직하게는, 본 발명에 있어 상기 면역크로마토그래피 분석용 스트립은Preferably, in the present invention, the strip for immunochromatographic analysis is

i) 지지체;i) a support;

ii) 분석하고자 하는 검체를 수용하고 버퍼 투입부 및 검체 투입부를 구비하는 검체 패드;ii) a sample pad for receiving a sample to be analyzed and having a buffer input unit and a sample input unit;

iii) 상기 검체 패드에서 유입된 검체에 함유되어 있는 코로나바이러스와 특이적으로 결합하는 결합 분자를 함유하는, 컨쥬게이트 패드;iii) a conjugate pad containing a binding molecule that specifically binds to the coronavirus contained in the sample introduced from the sample pad;

iv) 상기 검체에 코로나바이러스가 존재하는지 여부를 검출하는 신호검출부와 분석 물질의 존재 유무와 관계없이 검체가 흡수 패드로 이동하였는지 여부를 확인하는 대조부를 포함하는 신호 검출 패드; 및iv) a signal detection pad including a signal detection unit for detecting whether or not the coronavirus is present in the sample and a control unit for checking whether the sample has moved to the absorbent pad regardless of the presence or absence of an analyte; and

v) 신호 검출 반응이 종료된 검체를 흡수하는 흡수 패드를 포함할 수 있다. v) it may include an absorbent pad for absorbing the sample after the signal detection reaction has been completed.

본 발명에 있어, 본 발명에 따른 스트립은 사스-코로나바이러스-2(SARS-CoV-2) 표면의 스파이크 단백질(Spike protein, S protein)에 결합하는 결합 분자를 컨쥬게이트 패드 및 신호 검출 패드에 각각 포함할 수 있다. 본 발명에 있어, 상기 컨쥬게이트 패드와 신호 검출 패드에 포함된 SARS-CoV-2 S 단백질 결합 분자는 동일하거나, 다를 수 있다. 또한, 본 발명에 있어, 상기 컨쥬게이트 패드와 신호 검출 패드에 포함된 SARS-CoV-2 S 단백질 결합 분자는 앞서 상술한 서열을 포함하는 결합 분자일 수 있다. In the present invention, the strip according to the present invention contains a binding molecule that binds to a spike protein (S protein) on the surface of SARS-CoV-2 to the conjugate pad and the signal detection pad, respectively. may include In the present invention, the SARS-CoV-2 S protein binding molecule included in the conjugate pad and the signal detection pad may be the same or different. Also, in the present invention, the SARS-CoV-2 S protein binding molecule included in the conjugate pad and the signal detection pad may be a binding molecule including the above-described sequence.

본 발명에 따른 면역크로마토그래피 분석용 스트립에 있어서, 상기 컨쥬게이트 패드에 함유된 결합 분자는 금속 입자, 라텍스 입자, 형광물질 또는 효소로 라벨링될 수 있다. 일 예로서, 상기 금속 입자는 금 입자일 수 있다. 본 발명에 있어, 상기 금 입자는 금 콜로이드 입자일 수 있으나, 이에 한정되는 것은 아니다. In the strip for immunochromatographic analysis according to the present invention, the binding molecules contained in the conjugate pad may be labeled with metal particles, latex particles, fluorescent substances, or enzymes. As an example, the metal particles may be gold particles. In the present invention, the gold particles may be colloidal gold particles, but is not limited thereto.

보다 상세히, 본 발명에 있어, 본 발명에 따른 면역크로마토그래피 분석용 스트립의 컨쥬게이트 패드에 본 발명의 결합 분자는 검출 가능하게 표식될 수 있다. 생분자들을 표식시키는데 사용 가능한 다양한 방법들이 당업자에게 잘 알려져 있고, 본 발명의 범주 내에서 고려된다. 본 발명에 있어, 본 발명에서 사용될 수 있는 표식 종류의 예로는 효소, 방사성 동위원소, 콜로이드금속, 형광 화합물, 화학발광 화합물 및 생발광 화합물이 있다. 본 발명의 일 구체예에서, 상기 사용될 수 있는 표식은 형광물질(가령, 플루레신, 로다민, 텍사스 레드 등), 효소(가령, 고추냉이 퍼옥시다아제, β-갈락토시다아제, 알칼리포스파타 아제), 방사성 동위원소(가령, 32P 또는 125I), 바이오틴, 디곡시게닌, 콜로이드 금속, 화학발광 또는 생발광 화합물(가령, 디옥세탄, 루미놀 또는 아크리디늄)을 포함한다. 본 발명에 있어, 표식 방법으로는 효소 또는 바이오티닐기의 공유 결합법, 요오드화법, 인산화법, 바이오틴화법 등이 있으나, 이에 제한되지 않는다. 본 발명에 있어, 검출 방법으로는 오토라디오그래피, 형광 현미경, 직접 및 간접 효소반응 등이 있으나, 이에 제한되지는 않는다. 통상적으로 사용되는 검출 분석법으로는 방사성 동위원소 또는 비-방사성 동위원소 방법이 있다. 본 발명에 있어, 상기 검출 분석법의 일 예로웨스턴블롯팅, 오버레이-분석법, RIA(Radioimmuno Assay) 및 IRMA(ImmuneRadioimmunometric Assay), EIA(Enzyme Immuno Assay), ELISA(Enzyme Linked Immuno Sorbent Assay), FIA(Fluorescent Immuno Assay) 또는 CLIA(Chemioluminescent Immune Assay)이 있다.More specifically, in the present invention, the binding molecule of the present invention may be detectably labeled on the conjugate pad of the strip for immunochromatographic analysis according to the present invention. The various methods available for labeling biomolecules are well known to those skilled in the art and are contemplated within the scope of the present invention. In the present invention, examples of the types of labels that can be used in the present invention include enzymes, radioactive isotopes, colloidal metals, fluorescent compounds, chemiluminescent compounds and bioluminescent compounds. In one embodiment of the present invention, the label that can be used is a fluorescent substance (eg, fluorescein, rhodamine, Texas red, etc.), an enzyme (eg, horseradish peroxidase, β-galactosidase, alkaline phosphatase). ), radioactive isotopes (eg, 32P or 125I), biotin, digoxigenin, colloidal metals, chemiluminescent or bioluminescent compounds (eg, dioxetane, luminol or acridinium). In the present invention, the labeling method includes, but is not limited to, an enzyme or biotinyl group covalent bonding method, iodination method, phosphorylation method, biotinylation method, and the like. In the present invention, the detection method includes, but is not limited to, autoradiography, fluorescence microscopy, direct and indirect enzymatic reactions, and the like. Commonly used detection assays include radioactive isotope or non-radioactive isotope methods. In the present invention, an example of the detection assay Western blotting, overlay-assay, RIA (Radioimmuno Assay) and IRMA (ImmuneRadioimmunometric Assay), EIA (Enzyme Immuno Assay), ELISA (Enzyme Linked Immuno Sorbent Assay), FIA (Fluorescent Assay) Immuno Assay) or CLIA (Chemioluminescent Immune Assay).

본 발명에 따른 면역크로마토그래피 분석용 스트립에 있어서, 상기 검출은 육안, 광학, 전기화학, 또는 전기전도도에 의해 판독될 수 있으나, 이에 한정되는 것은 아니다. In the strip for immunochromatographic analysis according to the present invention, the detection may be read by visual, optical, electrochemical, or electrical conductivity, but is not limited thereto.

또한, 본 발명의 다른 일 구체예로, 본 발명은 본 발명에 따른 면역크로마토그래피 분석용 스트립을 포함하는, 사스-코로나바이러스 감염증(COVID-19)의 진단용 키트를 제공한다. In another embodiment of the present invention, the present invention provides a kit for diagnosis of SARS-coronavirus infection (COVID-19), comprising the strip for immunochromatographic analysis according to the present invention.

본 발명에 있어, 본 발명의 진단용 키트는 샘플과 본 발명에 따른 결합 분자를 접촉시킨 후, 반응을 확인하여 SARS-CoV-2의 존재 여부를 검출하는 데 사용될 수 있다. 본 발명에 있어, 상기 샘플은 대상의 가래, 침, 혈액, 땀, 폐 세포, 폐 조직의 점액, 호흡기 조직 및 타액으로 이루어진 군으로부터 선택된 어느 하나일 수 있으나, 이에 한정되지 않으며, 당업자에게 알려진 통상적인 방법으로 샘플 준비가 가능하다.In the present invention, the diagnostic kit of the present invention can be used to detect the presence or absence of SARS-CoV-2 by contacting a sample with the binding molecule according to the present invention, and then checking the reaction. In the present invention, the sample may be any one selected from the group consisting of sputum, saliva, blood, sweat, lung cells, lung tissue mucus, respiratory tissue and saliva, but is not limited thereto, and is not limited thereto. It is possible to prepare the sample in this way.

또한, 본 발명의 다른 일 구체예로, 본 발명은 상기 진단용 키트를 이용하여 사스-코로나바이러스-2(SARS-CoV-2)를 검출하는 방법을 제공한다. In another embodiment of the present invention, the present invention provides a method for detecting SARS-coronavirus-2 (SARS-CoV-2) using the diagnostic kit.

또한, 본 발명의 다른 일 구체예로, 본 발명은 상기 진단용 키트를 이용하여 사스-코로나바이러스 감염증(COVID-19)을 진단하는 방법을 제공한다. In another embodiment of the present invention, the present invention provides a method for diagnosing SARS-coronavirus infection (COVID-19) using the diagnostic kit.

본 발명의 다른 측면에서, 본 발명은 본 발명에 따른 결합 분자를 포함하는 사스-코로나바이러스 감염증(COVID-19) 진단, 예방 또는 치료용 키트를 제공한다. In another aspect of the present invention, the present invention provides a kit for diagnosing, preventing or treating SARS-coronavirus infection (COVID-19) comprising the binding molecule according to the present invention.

본 발명에 있어, 본 발명의 진단용 키트는 샘플과 본 발명에 따른 결합 분자를 접촉시킨 후, 반응을 확인하여 SARS-CoV-2의 존재 여부를 검출하는 데 사용될 수 있다. 본 발명에 있어, 상기 샘플은 대상의 가래, 침, 혈액, 땀, 폐 세포, 폐 조직의 점액, 호흡기 조직 및 타액으로 이루어진 군으로부터 선택된 어느 하나일 수 있으나, 이에 한정되지 않으며, 당업자에게 알려진 통상적인 방법으로 샘플 준비가 가능하다.In the present invention, the diagnostic kit of the present invention can be used to detect the presence or absence of SARS-CoV-2 by contacting a sample with the binding molecule according to the present invention, and then checking the reaction. In the present invention, the sample may be any one selected from the group consisting of sputum, saliva, blood, sweat, lung cells, lung tissue mucus, respiratory tissue and saliva, but is not limited thereto, and is not limited thereto. It is possible to prepare the sample in this way.

또한, 본 발명의 다른 일 구체예는 In addition, another embodiment of the present invention is

a) 본 발명에 따른 결합 분자; 및a) a binding molecule according to the invention; and

b) 용기b) container

를 포함하는 SARS-CoV-2로 인하여 발생하는 질환의 진단, 예방 또는 치료용 키트를 제공한다.It provides a kit for diagnosing, preventing or treating a disease caused by SARS-CoV-2 comprising a.

본 발명의 진단, 예방 또는 치료용 키트에 있어서, 상기 키트 용기에는 고체 담체가 포함될 수 있다. 본 발명에 있어, 본 발명의 항체는 고체 담체에 부착될 수 있고, 상기 고체 담체는 다공성 또는 비다공성, 평면 또는 비평면일 수 있다.In the diagnostic, prophylactic or therapeutic kit of the present invention, a solid carrier may be included in the kit container. In the present invention, the antibody of the present invention may be attached to a solid carrier, and the solid carrier may be porous or non-porous, planar or non-planar.

본 발명의 다른 측면에서, 본 발명은 사스-코로나바이러스 감염증(COVID-19)으로 인하여 발생하는 질환을 가진 대상에 본 발명에 따른 조성물을 치료학적으로 유효한 양으로 투여하는 단계를 포함하는, 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료 방법을 제공한다. 본 발명의 일 구체예에서, 상기 진단, 예방, 또는 치료 방법은 항-바이러스 약물, 바이러스 진입 억제제 또는 바이러스 부착 억제제를 투여하는 단계를 추가로 포함할 수 있다. In another aspect of the present invention, the present invention is SARS- comprising administering a composition according to the present invention in a therapeutically effective amount to a subject having a disease caused by coronavirus infection (COVID-19), SARS- A method for diagnosing, preventing or treating a disease caused by a coronavirus infection is provided. In one embodiment of the present invention, the diagnosis, prevention, or treatment method may further comprise administering an anti-viral drug, a virus entry inhibitor or a virus adhesion inhibitor.

본 발명의 다른 측면에서, 본 발명은 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료용 결합 분자를 선별하는 방법을 제공한다. 본 발명의 일 구체예에서, 본 발명은 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질(Spike protein, S protein)의 RBD(Receptor Binding Domain) 내 에피토프와의 결합 여부를 확인하여, 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료용 결합 분자를 선별하는 방법으로서, 상기 결합 분자의 에피토프는 사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 417, 449, 453, 455, 456, 484, 486, 489, 490, 493, 496 및 505로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 잔기(residue)를 포함하고, 상기 에피토프 및 결합 분자가 결합을 보이는 경우 상기 결합 분자를 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료용 후보 물질로 판단하는 것을 특징으로 하는, 방법을 제공한다. 여기서, 본 발명에 따른 결합 분자의 에피토프는 사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 403, 450, 452, 483, 485, 492, 494 및 495로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 잔기를 추가로 포함할 수 있다. 여기서 '결합 분자'는, 본 명세서에서 상술한 결합 분자 관련 일체의 내용이 그대로 적용된다. In another aspect of the present invention, the present invention provides a method for screening a binding molecule for diagnosis, prevention or treatment of a disease caused by SARS-coronavirus infection. In one embodiment of the present invention, the present invention confirms whether or not binding to an epitope in RBD (Receptor Binding Domain) of a spike protein (S protein) of SARS-CoV-2 , SARS- A method of screening a binding molecule for the diagnosis, prevention or treatment of a disease caused by infection, wherein the epitope of the binding molecule is at amino acid positions 417, 449, 453, of the SARS-coronavirus-2 spike protein; 455, 456, 484, 486, 489, 490, 493, 496 and 505, wherein the binding molecule is SARS- It provides a method, characterized in that it is determined as a candidate material for diagnosis, prevention or treatment of a disease caused by coronavirus infection. Here, the epitope of the binding molecule according to the present invention is one or more amino acid residues selected from the group consisting of amino acid positions 403, 450, 452, 483, 485, 492, 494 and 495 of the SARS-coronavirus-2 spike protein. can be included as Here, as for the 'binding molecule', all contents related to the binding molecule described above in this specification are applied as it is.

본 발명의 다른 측면에서, 본 발명은 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료용 결합 분자를 생산하는 방법을 제공한다. 본 발명의 일 구체예에서, 본 발명은 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질(Spike protein, S protein)의 RBD(Receptor Binding Domain) 내 에피토프와의 결합 여부를 확인하여, 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료용 결합 분자를 생산하는 방법으로서, 상기 결합 분자의 에피토프는 사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 417, 449, 453, 455, 456, 484, 486, 489, 490, 493, 496 및 505로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 잔기(residue)를 포함하고, 상기 에피토프 및 결합 분자가 결합을 보이는 경우 상기 결합 분자를 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료용 후보 물질로 판단하는 것을 특징으로 하는, 방법을 제공한다. 여기서, 본 발명에 따른 결합 분자의 에피토프는 사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 403, 450, 452, 483, 485, 492, 494 및 495로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 잔기를 추가로 포함할 수 있다. 여기서 '결합 분자'는, 본 명세서에서 상술한 결합 분자 관련 일체의 내용이 그대로 적용된다.In another aspect of the present invention, the present invention provides a method for producing a binding molecule for diagnosis, prevention or treatment of a disease caused by SARS-coronavirus infection. In one embodiment of the present invention, the present invention confirms whether or not binding to an epitope in RBD (Receptor Binding Domain) of a spike protein (S protein) of SARS-CoV-2 , SARS- A method of producing a binding molecule for the diagnosis, prevention or treatment of a disease caused by infection, wherein the epitope of the binding molecule is at amino acid positions 417, 449, 453 of the SARS-coronavirus-2 spike protein; 455, 456, 484, 486, 489, 490, 493, 496 and 505, wherein the binding molecule is SARS- It provides a method, characterized in that it is determined as a candidate material for diagnosis, prevention or treatment of a disease caused by coronavirus infection. Here, the epitope of the binding molecule according to the present invention is one or more amino acid residues selected from the group consisting of amino acid positions 403, 450, 452, 483, 485, 492, 494 and 495 of the SARS-coronavirus-2 spike protein. can be included as Here, as for the 'binding molecule', all contents related to the binding molecule described above in this specification are applied as it is.

이하 본 발명에서 사용되는 용어를 다음과 같이 정의한다.Hereinafter, terms used in the present invention are defined as follows.

본 발명에 있어, 용어 "결합 분자"는 키메라, 인간화 또는 인간 단일클론 항체와 같은 단일클론 항체를 포함하는 온전한(intact) 이뮤노글로불린(immunoglobulin), 또는 항원에 결합하는 이뮤노글로불린인 항원-결합 단편을 포함한다. 예를 들면 SARS-CoV-2의 스파이크 단백질(spike protein)과 결합에 있어서, 온전한(intact) 이뮤노글로불린과 경쟁하는 이뮤노글로불린 단편을 포함하는 가변성 도메인, 효소, 수용체, 단백질을 뜻한다. 구조와는 상관없이 항원-결합 단편은 온전한(intact) 이뮤노글로불린에 의해 인식된 동일한 항원과 결합된다. 본 발명에 있어, 상기 항원-결합 단편은 항체의 아미노산 서열의 2개 이상의 연속기, 20개 이상의 연속 아미노산 잔기, 25개 이상의 연속 아미노산 잔기, 30개 이상의 연속 아미노산 잔기, 35개 이상의 연속 아미노산 잔기, 40개 이상의 연속 아미노산 잔기, 50개 이상의 연속 아미노산 잔기, 60개 이상의 연속 아미노산 잔기, 70개 이상의 연속 아미노산 잔기, 80개 이상의 연속 아미노산 잔기, 90개 이상의 연속 아미노산 잔기, 100개 이상의 연속 아미노산 잔기, 125개 이상의 연속 아미노산 잔기, 150개 이상의 연속 아미노산 잔기, 175개 이상 연속 아미노산 잔기, 200개 이상의 연속 아미노산 잔기, 또는 250개 이상의 연속 아미노산 잔기의 아미노산 서열을 포함하는 펩티드 또는 폴리펩티드를 포함할 수 있다. As used herein, the term "binding molecule" refers to an intact immunoglobulin, including monoclonal antibodies, such as chimeric, humanized or human monoclonal antibodies, or antigen-binding, which is an immunoglobulin that binds to an antigen. Includes fragments. For example, in binding to the spike protein of SARS-CoV-2, it refers to a variable domain, enzyme, receptor, or protein comprising an immunoglobulin fragment that competes with an intact immunoglobulin. Regardless of structure, the antigen-binding fragment binds to the same antigen recognized by the intact immunoglobulin. In the present invention, the antigen-binding fragment comprises two or more contiguous groups of the amino acid sequence of the antibody, 20 or more contiguous amino acid residues, 25 or more contiguous amino acid residues, 30 or more contiguous amino acid residues, 35 or more contiguous amino acid residues, 40 at least 50 contiguous amino acid residues, at least 60 contiguous amino acid residues, at least 70 contiguous amino acid residues, at least 80 contiguous amino acid residues, at least 90 contiguous amino acid residues, at least 100 contiguous amino acid residues, 125 a peptide or polypeptide comprising an amino acid sequence of at least 150 contiguous amino acid residues, at least 150 contiguous amino acid residues, at least 175 contiguous amino acid residues, at least 200 contiguous amino acid residues, or at least 250 contiguous amino acid residues.

본 발명에 있어, 용어 "항원-결합 단편"은 특히 Fab, F(ab'), F(ab')2, Fv, dAb, Fd, 상보성 결정 영역(CDR) 단편, 단일-쇄 항체(scFv), 2가(bivalent) 단일-쇄 항체, 단일-쇄 파지 항체, 디아바디(diabody), 트리아바디, 테트라바디, 폴리펩티드로의 특정 항원에 결합하기에 충분한 이뮤노글로불린의 하나 이상의 단편을 함유하는 폴리펩티드 등을 포함한다. 본 발명에 있어, 상기 단편은 합성으로 또는 완전한 이뮤노글로불린의 효소적 또는 화학적 분해에 의해 생성되거나, 재조합 DNA 기술에 의해 유전공학적으로 생성될 수 있다. 본 발명에 있어, 상기 단편 생성 방법은 당업계에 잘 알려져 있는 생성 방법을 의미한다.In the context of the present invention, the term "antigen-binding fragment" particularly refers to Fab, F(ab'), F(ab')2, Fv, dAb, Fd, complementarity determining region (CDR) fragments, single-chain antibodies (scFv). , bivalent single-chain antibodies, single-chain phage antibodies, diabodies, triabodies, tetrabodies, polypeptides containing one or more fragments of an immunoglobulin sufficient to bind a particular antigen to the polypeptide. etc. In the present invention, the fragment may be produced synthetically or by enzymatic or chemical degradation of complete immunoglobulin, or may be genetically engineered by recombinant DNA technology. In the present invention, the fragment generation method refers to a production method well known in the art.

본 발명에 있어, 용어 "약제학적으로 허용 가능한 부형제"는 용인 가능한 또는 편리한 투약 형태를 제조하기 위한 약물, 제제 또는 항체와 같은 활성 분자로 조합되는 불활성 물질을 의미한다. 본 발명에 있어, 상기 약제학적으로 허용 가능한 부형제는 비독성이거나, 적어도 독성이 사용된 용량 및 농도에서 수용자에게 이의 의도된 용도를 위해 허용될 수 있는 부형제이고, 약물, 제제 또는 결합 분제를 포함하는 제형의 다른 성분과 양립할 수 있다.As used herein, the term "pharmaceutically acceptable excipient" refers to an inert substance that is combined into an active molecule such as a drug, agent or antibody to prepare an acceptable or convenient dosage form. In the present invention, the pharmaceutically acceptable excipient is an excipient that is non-toxic, or at least toxic, is acceptable for its intended use to the recipient at the used dose and concentration, and includes a drug, agent or binding agent. It is compatible with the other ingredients of the formulation.

본 발명에 있어, 용어 "치료학적으로 유효한 양"은 SARS-CoV-2의 노출 전 또는 노출 후에 예방 또는 치료에 유효한 본 발명의 결합 분자의 양을 나타낸다.In the present invention, the term "therapeutically effective amount" refers to an amount of the binding molecule of the present invention effective for prophylaxis or treatment before or after exposure to SARS-CoV-2.

본원에 기재된 상기 각 특징들은 조합되어 사용될 수 있으며, 상기 각 특징들이 특허청구범위의 서로 다른 종속항에 기재된다는 사실이 이들이 조합되어 사용될 수 없음을 나타내는 것은 아니다. Each of the features described herein may be used in combination, and the fact that each of the features is recited in different dependent claims of the claims does not indicate that they cannot be used in combination.

본 발명의 결합 분자는 사스-코로나바이러스-2 표면의 스파이크 단백질의 RBD 내 특정 에피토프에 특이적으로 결합하고, 우수한 결합 능력을 가지며, 사스-코로나바이러스-2에 우수한 중화 효과를 가지므로, 사스-코로나바이러스 감염증(COVID-19)에 대한 진단, 예방 또는 치료에 매우 유용하다.The binding molecule of the present invention specifically binds to a specific epitope in the RBD of the spike protein on the SARS-coronavirus-2 surface, has an excellent binding ability, and has an excellent neutralizing effect on SARS-coronavirus-2, so SARS- Very useful for diagnosis, prevention or treatment of coronavirus infection (COVID-19).

도 1a는 본 발명의 결합 분자를 이용한 페렛 동물 실험 중 SARS-CoV-2 바이러스 접종 후 Vero 세포를 이용하여 페렛의 비강 세척액 샘플 내 바이러스 역가를 측정한 결과이다.
도 1b는 본 발명의 결합 분자를 이용한 페렛 동물 실험 중 SARS-CoV-2 바이러스 접종 후 qRT-PCR을 이용하여 페렛의 비강 세척액, 타액 및 직장 스왑 샘플 내 바이러스 역가를 측정한 결과이다.
도 1c는 본 발명의 결합 분자를 이용한 페렛 동물 실험 중 SARS-CoV-2 바이러스 접종 후 Vero 세포를 이용하여 페렛의 비갑개 조직 및 폐 조직 내 바이러스 역가를 측정한 결과이다.
도 1d는 본 발명의 결합 분자를 이용한 페렛 동물 실험 중 SARS-CoV-2 바이러스 접종 후 qRT-PCR을 이용하여 페렛의 비갑개 조직 및 폐 조직 내 바이러스 역가를 측정한 결과이다.
도 2는 본 발명의 결합 분자를 이용한 페렛 동물 실험에서 SARS-CoV-2 바이러스 감염 3일째와 7일째 부검 후 페렛의 폐 조직을 관찰한 현미경 사진이다.
도 3a는 본 발명의 결합 분자를 이용한 골든시리안햄스터 동물 실험 중 SARS-CoV-2 바이러스 감염 전 및 후 6일 동안 매일 각 군의 개체별 체중을 평가한 결과이다.
도 3b는 본 발명의 결합 분자를 이용한 골든시리안햄스터 동물 실험 중 SARS-CoV-2 바이러스 접종 후 qRT-PCR을 이용하여 골든시리안햄스터의 폐 바이러스 역가를 측정한 결과이다.
도 3c는 본 발명의 결합 분자를 이용한 골든시리안햄스터 동물 실험 중 SARS-CoV-2 바이러스 접종 후 qRT-PCR을 이용하여 골든시리안햄스터의 비갑개 바이러스 역가를 측정한 결과이다.
도 3d는 본 발명의 결합 분자를 이용한 골든시리안햄스터 동물 실험 중 SARS-CoV-2 바이러스 접종 후 qRT-PCR을 이용하여 골든시리안햄스터의 십이지장 바이러스 역가를 측정한 결과이다.
도 3e는 본 발명의 결합 분자를 이용한 골든시리안햄스터 동물 실험 중 SARS-CoV-2 바이러스 접종 후 Vero 세포를 이용하여 골든시리안햄스터의 폐 조직의 바이러스 역가를 측정한 결과이다.
도 4a는 본 발명의 결합 분자를 이용한 마우스 동물 실험 중 SARS-CoV-2 바이러스 감염 전 및 후 6일 동안 매일 각 군의 개체별 체중을 평가한 결과이다.
도 4b는 본 발명의 결합 분자를 이용한 마우스 동물 실험 중 SARS-CoV-2 바이러스 접종 후 Vero 세포를 이용하여 마우스의 폐 조직의 바이러스 역가를 측정한 결과이다.
도 4c는 본 발명의 결합 분자를 이용한 마우스 동물 실험 중 SARS-CoV-2 바이러스 접종 후 Vero 세포를 이용하여 마우스의 비강세척액의 바이러스 역가를 측정한 결과이다.
도 5a는 본 발명의 결합 분자를 이용한 페렛 동물 실험 중 SARS-CoV-2 wild-type 및 변이 바이러스(B.1.351) 감염 전 및 후 각각 6일, 4일동안 매일 각 군의 개체별 체중을 평가한 결과이다.
도 5b는 본 발명의 결합 분자를 이용한 패렛 동물 실험 중 SARS-CoV-2 wild-type 및 변이 바이러스(B.1.351) 접종 후 qRT-PCR을 이용하여 페렛의 비강 세척액, 비갑개, 폐 바이러스 역가를 측정한 결과이다.
도 5c는 본 발명의 결합 분자를 이용한 패렛 동물 실험 중 SARS-CoV-2 wild-type 및 변이 바이러스(B.1.351) 접종 후 Vero 세포를 이용하여 페렛의 비강 세척액, 비갑개, 폐 바이러스 역가를 측정한 결과이다.
도 6a는 본 발명의 결합 분자를 이용한 브라질 변이 바이러스에 대한 마우스 중화능 평가 실험 결과로, 본 발명의 결합 분자 투여에 따른 개체군들의 체중 변화를 나타낸 결과이다 (도 6a에서, a는 p<0.0001의 대조군과 투여군 (pooled) 간의 유의 수준을 나타내며; b는 p<0.01에서 p<0.05의 대조군과 80 mg/kg 투여군 간의 유의 수준을 나타내며; c는 p<0.0001에서 p<0.01의 대조군과 5, 20, 40, 80 mg/kg 투여군 간의 유의 수준을 나타내며; d는 p<0.0001에서 p<0.001의 대조군과 5, 20, 40, 80 mg/kg 투여군 간의 유의 수준을 나타낸다.).
도 6b는 본 발명의 결합 분자를 이용한 브라질 변이 바이러스에 대한 마우스 중화능 평가 실험 결과로, 플라크 분석으로 측정한 폐 조직에서의 바이러스 역가를 나타낸 결과이다 (도 6b에서, *과 ****는 각각 p<0.05와 p<0.0001의 대조군과 투여군 간의 유의 수준을 나타낸다.).
도 6c는 본 발명의 결합 분자를 이용한 브라질 변이 바이러스에 대한 마우스 중화능 평가 실험 결과로, 플라크 분석으로 측정한 비강세척액에서의 바이러스 역가를 나타낸 결과이다.
도 7a는 X선 회절분석법을 이용하여 본 발명의 일 실시예에 따른 No. 139 항체 분절이 SARS-CoV-2 RBD 단백질 상에 결합하는 아미노산 서열을 분석한 결과를 나타낸 것이다.
도 7b는 SARS-CoV-2 RBD / ACE2 단백질 복함체 구조 (PDB코드, 6LZG)를 나타낸 것이다.
도 7c는 SARS-CoV-2 RBD / No. 139 항체와 SARS-CoV-2 RBD / ACE2 를 슈퍼임포즈 (superimpose)한 그림을 나타낸 것이다.
도 7d는 본 발명의 일 실시예에 따른 No. 139 항체가 SARS-CoV-2 RBD 단백질에 결합하는 에피토프 위치를 RBD 공간 구조 위에 표시한 것이다.
도 7e는 ACE2가 SARS-CoV-2 RBD에 결합하는 공간적인 위치를 나타낸 것이다.
도 8은 본 발명의 일 실시예에 따른 No. 139 항체의 중쇄 CDR 1/2/3과 SARS-CoV-2 RBD 단백질의 상세 결합을 나타낸 것이다.
도 9는 정제된 다양한 재조합 SARS-CoV-2-RBD 단백질에 대한 본 발명의 일 실시예에 따른 No. 139 항체의 결합친화도를 결정한 결과를 나타낸 것이다.
도 10은 크기 배제 크로마토그래피법(Size Exclusion Chromatography, SEC-HPLC)을 이용하여, 항체의 비정상적인 파편 (Fragment, LMW) 또는 응집 (Aggregation, HMW)의 발생 유무, 정상 항체의 항체 구조의 비율을 평가한 결과를 나타낸 것이다.
도 11은 모세관 전기영동 분석 (Capillary Electrophoresis, CE)을 통해서 비환원 조건 (Non-reduced condition)에서의 Intact IgG의 순도 비율과, 환원 조건 (Reduced condition)에서의 항체 중쇄/경쇄합 비율 (Sum of Heavy & Light Chain)을 평가한 결과를 나타낸 것이다.
도 12는 본 발명의 일 실시예에 따른 No. 139 항체의 결합 특이성을 Octet 분석을 진행하여 평가한 결과를 나타낸 것이다.
도 13은 본 발명의 일 실시예에 따른 No. 139 항체의 작용 기전 (mechanism of action)을 Octet을 이용하여 Biolayer interference (BLI) 분석을 진행하여 평가한 결과를 나타낸 것이다.1A is a result of measuring the virus titer in a nasal wash sample of a ferret using Vero cells after SARS-CoV-2 virus inoculation during a ferret animal experiment using the binding molecule of the present invention.
Figure 1b shows the results of measuring the virus titer in the nasal wash, saliva and rectal swab samples of ferrets using qRT-PCR after SARS-CoV-2 virus inoculation during an animal experiment using the binding molecule of the present invention.
Figure 1c is a result of measuring the virus titer in the nasal turbinate tissue and lung tissue of the ferret using Vero cells after SARS-CoV-2 virus inoculation during a ferret animal experiment using the binding molecule of the present invention.
Figure 1d shows the results of measuring the viral titers in the nasal turbinate tissue and lung tissue of the ferret using qRT-PCR after SARS-CoV-2 virus inoculation during a ferret animal experiment using the binding molecule of the present invention.
2 is a micrograph of the lung tissue of a ferret after autopsy on the 3rd and 7th days of SARS-CoV-2 virus infection in a ferret animal experiment using the binding molecule of the present invention.
Figure 3a is a result of evaluating the weight of each individual in each group every day for 6 days before and after SARS-CoV-2 virus infection in a Golden Syrian hamster animal experiment using the binding molecule of the present invention.
Figure 3b is a result of measuring the lung virus titer of the Golden Syrian hamster using qRT-PCR after SARS-CoV-2 virus inoculation during an animal experiment using the binding molecule of the present invention.
Figure 3c shows the results of measuring the turbinate virus titer of the Golden Syrian hamster using qRT-PCR after SARS-CoV-2 virus inoculation during animal experiments using the binding molecule of the present invention.
Figure 3d shows the results of measuring the duodenal virus titer of the Golden Syrian hamster using qRT-PCR after SARS-CoV-2 virus inoculation during animal experiments using the binding molecule of the present invention.
Figure 3e is a result of measuring the viral titer of the lung tissue of the Golden Syrian hamster using Vero cells after SARS-CoV-2 virus inoculation during animal experiments using the binding molecule of the present invention.
Figure 4a is a result of evaluating the body weight of each individual in each group every day for 6 days before and after SARS-CoV-2 virus infection in a mouse animal experiment using the binding molecule of the present invention.
Figure 4b is a result of measuring the virus titer of the lung tissue of the mouse using Vero cells after SARS-CoV-2 virus inoculation during a mouse animal experiment using the binding molecule of the present invention.
Figure 4c is a result of measuring the virus titer of the nasal wash of the mouse using Vero cells after SARS-CoV-2 virus inoculation during a mouse animal experiment using the binding molecule of the present invention.
5a is a ferret animal experiment using the binding molecule of the present invention before and after infection with SARS-CoV-2 wild-type and mutant virus (B.1.351), respectively, for 6 days and 4 days, each individual body weight of each group was evaluated. is a result
Figure 5b is a ferret nasal wash solution, nasal turbinate, lung virus titers using qRT-PCR after SARS-CoV-2 wild-type and mutant virus (B.1.351) inoculation during an experiment in a parrot animal using the binding molecule of the present invention. is a result
Figure 5c is a ferret nasal lavage solution, nasal turbinate, lung virus titers were measured using Vero cells after SARS-CoV-2 wild-type and mutant virus (B.1.351) inoculation during a ferret animal experiment using the binding molecule of the present invention. It is the result.
Figure 6a is the result of the mouse neutralizing ability evaluation experiment for the Brazilian mutant virus using the binding molecule of the present invention, showing the change in body weight of the population according to the administration of the binding molecule of the present invention (in Fig. 6a, a is p < 0.0001 Indicates the significance level between the control group and the administration group (pooled); b indicates the significance level between the control group at p<0.05 and the 80 mg/kg administration group at p<0.01; c shows the control group at p<0.0001 and the control group at p<0.01 and 5, 20 , indicates the significance level between the groups administered with 40 and 80 mg/kg; d indicates the level of significance between the control group at p<0.0001 and the control group at p<0.001 and the groups administered with 5, 20, 40, and 80 mg/kg).
Figure 6b is the result of the mouse neutralizing ability evaluation experiment for the Brazilian mutant virus using the binding molecule of the present invention, showing the virus titer in the lung tissue measured by plaque analysis (in Figure 6b, * and **** are Significance levels between the control group and the administration group of p<0.05 and p<0.0001 are shown, respectively).
Figure 6c shows the results of the mouse neutralizing ability evaluation experiment for the Brazilian mutant virus using the binding molecule of the present invention, showing the virus titer in the nasal wash as measured by plaque analysis.
7a is a No. 7 according to an embodiment of the present invention using X-ray diffraction analysis. The results of analysis of the amino acid sequence binding to the 139 antibody fragment on the SARS-CoV-2 RBD protein are shown.
Figure 7b shows the structure of the SARS-CoV-2 RBD / ACE2 protein complex (PDB code, 6LZG).
7c shows SARS-CoV-2 RBD/No. The figure shows the superimpose of 139 antibody and SARS-CoV-2 RBD / ACE2.
7d is a No. 7 according to an embodiment of the present invention. The epitope position at which the 139 antibody binds to the SARS-CoV-2 RBD protein is indicated on the RBD spatial structure.
7e shows the spatial location of ACE2 binding to SARS-CoV-2 RBD.
8 is a No. 8 according to an embodiment of the present invention. The detailed binding of the heavy chain CDR 1/2/3 of antibody 139 and the SARS-CoV-2 RBD protein is shown.
9 is a No. 9 according to an embodiment of the present invention for various purified recombinant SARS-CoV-2-RBD proteins. The results of determining the binding affinity of the 139 antibody are shown.
Figure 10 is using size exclusion chromatography (Size Exclusion Chromatography, SEC-HPLC), the occurrence of abnormal fragments (Fragment, LMW) or aggregation (Aggregation, HMW) of the antibody, evaluation of the ratio of the antibody structure of the normal antibody one result is shown.
11 shows the purity ratio of Intact IgG in a non-reduced condition through capillary electrophoresis (CE) and an antibody heavy chain/light chain combination ratio in a reduced condition (Sum of It shows the results of evaluation of Heavy & Light Chain).
12 is a No. 12 according to an embodiment of the present invention. The results of evaluation of the binding specificity of the 139 antibody by Octet analysis are shown.
13 is a No. 13 according to an embodiment of the present invention. The mechanism of action of the 139 antibody shows the results of evaluation by performing Biolayer interference (BLI) analysis using Octet.

이하 본 발명을 실시예를 통해 상세히 설명한다. 그러나 하기 실시예들은 본 발명의 내용을 예시하는 것일 뿐 발명의 범위가 실시예에 의해 한정되지 않는다. Hereinafter, the present invention will be described in detail through examples. However, the following examples are merely illustrative of the content of the present invention, and the scope of the present invention is not limited by the examples.

본 발명에서 인용된 문헌 및 본 출원인이 기출원한 한국등록특허 제10-2205028호 및 PCT국제출원 PCT/KR2021/003498는 본 발명의 명세서에 참조로서 통합된다.Documents cited in the present invention, Korean Patent No. 10-2205028 and PCT International Application PCT/KR2021/003498 previously filed by the present applicant are incorporated herein by reference.

실시예 1: SARS-CoV-2 회복 환자의 혈액으로부터 PBMC 분리Example 1: Isolation of PBMCs from the blood of patients recovering from SARS-CoV-2

혈액의 공여자는 2020년 SARS-CoV-2에 감염되었음을 확진 받고 치료를 통하여 더 이상 바이러스가 검출되지 않은 사람들이다. 공여자 선정과 채혈 과정은 임상시험심사 위원회(IRB)의 승인을 받고 이루어졌다. 공여자 선정 후 약 30㎖의 전혈을 채혈하고 Ficoll-PaqueTM PLUS(GE Healthcare) 방법을 사용하여 PBMC(peripheral blood mononuclear cell)를 분리하였다. 분리된 PBMC는 인산 완충용액으로 2회 세척한 후, 냉동 배지(RPMI:FBS:DMSO = 5:4:1)로 1x107cells/㎖ 농도로 맞추어 액체 질소 탱크(Liquid Nitrogen Tank)에 보관하였다.Blood donors are those who were confirmed to have been infected with SARS-CoV-2 in 2020 and whose virus was no longer detected through treatment. The donor selection and blood collection process was approved by the Institutional Review Board (IRB). After selecting a donor, about 30 ml of whole blood was collected and peripheral blood mononuclear cells (PBMCs) were isolated using the Ficoll-Paque TM PLUS (GE Healthcare) method. The separated PBMCs were washed twice with phosphate buffer, then adjusted to a concentration of 1x10 7 cells/ml with a freezing medium (RPMI:FBS:DMSO = 5:4:1) and stored in a liquid nitrogen tank (Liquid Nitrogen Tank).

실시예 2: 항체 디스플레이된 파아지 라이브러리(phage library) 제작Example 2: Preparation of antibody-displayed phage library

실시예 1에서 분리한 PBMC에서 Trizol Reagent(Invitrogen)를 이용하여 전체 RNA를 추출한 후 the SuperScriptTM III First-Strand cDNA synthesis system(Invitrogen, USA)을 이용하여 cDNA를 합성하였다.Total RNA was extracted from the PBMC isolated in Example 1 using Trizol Reagent (Invitrogen), and then cDNA was synthesized using the SuperScript™ III First-Strand cDNA synthesis system (Invitrogen, USA).

합성된 cDNA로부터 항체 라이브러리의 제작은 선행문헌을 참고하였다(Barbas C. et. al. Phage display a laboratory manual. 2001. CSHL Press). 간단히 기술하면 합성된 cDNA로부터 High fidelity Taq polymerase(Roche)와 디제너레이티브 프라이머 세트(degenerative primer set)(IDT)를 이용하여 항체의 경쇄와 중쇄의 가변 영역을 PCR(polymerase chain reaction) 방법으로 증폭하였다. 분리된 경쇄와 중쇄의 가변영역 절편들이 무작위 조합으로 하나의 서열로서 연결되도록 overlap PCR 방법으로 scFv 형태의 유전자로 만들어 증폭한 후 제한 효소로 절단하고 1% 아가로스 겔 전기영동(agarose gel electrophoresis)과 gel extraction kit(Qiagen) 방법을 사용하여 scFv를 분리하였다. 파아지 벡터도 동일한 제한 효소로 절단하고 분리한 뒤 상기 scFv 유전자와 섞고 T4 DNA ligase(New England Biolab)를 넣은 후 16℃에서 12시간 이상 반응하였다. 반응액을 ER2738 수용성 세포(competent cell)와 섞고 전기천공(electroporation) 방법으로 형질 전환하였다. 형질 전환된 ER2738은 진탕 배양 후 VCSM13 helper phage(Agilent Technologies)를 넣고 12시간 이상 배양하였다.For the preparation of an antibody library from the synthesized cDNA, the literature was referred to (Barbas C. et. al. Phage display a laboratory manual. 2001. CSHL Press). In brief, the variable regions of the light and heavy chains of the antibody are amplified by PCR (polymerase chain reaction) method using high fidelity Taq polymerase (Roche) and degenerative primer set (IDT) from the synthesized cDNA. did So that the variable region fragments of the separated light and heavy chains are connected as one sequence in a random combination, the scFv-type gene is created and amplified by the overlap PCR method, cut with restriction enzymes, and 1% agarose gel electrophoresis and scFv was isolated using the gel extraction kit (Qiagen) method. The phage vector was also digested with the same restriction enzyme and separated, mixed with the scFv gene, added with T4 DNA ligase (New England Biolab), and reacted at 16° C. for more than 12 hours. The reaction solution was mixed with ER2738 competent cells and transformed by electroporation. Transformed ER2738 was cultured with shaking, followed by VCSM13 helper phage (Agilent Technologies) and incubated for more than 12 hours.

실시예 3: 파아지 효소 면역분석을 이용한 선별Example 3: Selection using phage enzyme immunoassay

실시예 2 에서 제작한 파아지 라이브러리 배양액을 원심 분리하여 숙주세포를 제거한 뒤 4% PEG와 0.5M NaCl을 넣고 원심 분리하여 파아지를 침강 시키고 상층액을 제거하였다. 침강된 파아지를 1% BSA/TBS 에 희석하여 파아지 라이브러리를 얻었다. 이후 다양한 SARS-CoV-2 Spike 단백질(이하, S 단백질)들에 대한 결합 및 해리 반응으로 패닝(panning)을 독립적으로 진행하여 SARS-CoV-2 S 단백질에 대한 결합능력을 갖는 scFv-파아지를 분리하였다. SARS-CoV-2 S 단백질의 한 부분인 RBD(Receptor binding domain) 영역(residues N331 to V524 on S1 glycoprotein)이 결합된 ELISA 플레이트(plate)에 파아지 라이브러리를 넣고 상온에서 2시간 동안 반응시켰다. 반응액을 제거한 뒤 ELISA 플레이트를 0.05% tween 20이 포함된 PBS로 세척한 뒤 60㎕ 의 0.1M glycine-HCl(pH 2.2)를 넣어 항원에 결합한 scFv-파아지를 떼어내고 2M Tris(pH 9.1)를 이용하여 중화하였다. 중화된 scFv-파아지는 ER2738에 감염시킨 뒤 보조(helper) 파아지를 넣고 배양하여 다음 번 패닝에 사용하였다. 감염시킨 ER2738의 일부는 보조 파아지를 넣기 전에 LB 플레이트에 도말하여 다음날 콜로니(colony)를 얻었다.The phage library culture medium prepared in Example 2 was centrifuged to remove host cells, 4% PEG and 0.5 M NaCl were added thereto, centrifuged to settle the phage, and the supernatant was removed. The precipitated phage was diluted in 1% BSA/TBS to obtain a phage library. Thereafter, panning was independently performed through binding and dissociation reactions to various SARS-CoV-2 Spike proteins (hereinafter, S protein) to isolate scFv-phages having binding ability to SARS-CoV-2 S protein. did The phage library was placed on an ELISA plate to which the receptor binding domain (RBD) region (residues N331 to V524 on S1 glycoprotein), a part of the SARS-CoV-2 S protein, was bound, and reacted at room temperature for 2 hours. After removing the reaction solution, the ELISA plate was washed with PBS containing 0.05% tween 20, and 60 μl of 0.1M glycine-HCl (pH 2.2) was added to remove the antigen-bound scFv-phage, and 2M Tris (pH 9.1) was added. was used for neutralization. After the neutralized scFv-phage was infected with ER2738, a helper phage was added and cultured to be used for the next panning. A portion of the infected ER2738 was plated on an LB plate before adding auxiliary phages, and colonies were obtained the next day.

각 패닝마다 형성된 콜로니는 96-well deep well plate(Axygen)에 담긴 배양액에 넣어 진탕 배양하고, OD600이 0.7 이상의 값이 되었을 때 보조 파아지를 넣은 후 37℃에서 12시간 이상 진탕 배양하였다. 배양액을 원심 분리하여 숙주세포를 제거하고 scFv-파아지를 포함하는 상등액을 준비하였다.Colonies formed for each panning were put into a culture medium contained in a 96-well deep well plate (Axygen) and cultured with shaking. When the OD600 reached a value of 0.7 or higher, auxiliary phages were added and then cultured with shaking at 37°C for more than 12 hours. The culture medium was centrifuged to remove host cells, and a supernatant containing scFv-phages was prepared.

준비된 scFv-파아지 상등액을 6% BSA/PBS 와 1:1 희석한 뒤 SARS-CoV-2 S 단백질들을 흡착 후 블로킹(blocking)한 96-웰 마이크로타이터 플레이트의 각 웰에 넣고 37℃에서 2시간 동안 정치하였다. 각 웰을 0.05% Tween 20가 포함된 PBS로 3회 세척한 뒤 HRP(겨자무과산화효소, horseradish peroxidase)가 표지된 항 M13 항체를 넣고 37℃에서 1시간 동안 정치하였다. 각 웰을 0.05% Tween 20가 포함된 PBS로 3회 세척한 뒤 ABTS(2,2'-Azinobis [3-ethylbenzothiazoline-6-sulfonic acid]-diammonium salt)를 넣고 405nm 에서의 흡광도를 측정하여 SARS-CoV-2 S 항원 단백질에 대한 결합력을 갖는 scFv-파아지를 선별하였다.The prepared scFv-phage supernatant was diluted 1:1 with 6% BSA/PBS, and then put into each well of a 96-well microtiter plate in which SARS-CoV-2 S proteins were adsorbed and blocked and placed at 37°C for 2 hours. been in politics for a while. Each well was washed 3 times with PBS containing 0.05% Tween 20, then HRP (mustard peroxidase, horseradish peroxidase)-labeled anti-M13 antibody was added thereto, and then left at 37°C for 1 hour. After washing each well 3 times with PBS containing 0.05% Tween 20, add ABTS (2,2'-Azinobis [3-ethylbenzothiazoline-6-sulfonic acid]-diammonium salt) and measure the absorbance at 405 nm to SARS- ScFv-phages having binding affinity to CoV-2 S antigen protein were selected.

실시예 4: scFv-Fc 항체 분절의 결합능 확인Example 4: Confirmation of binding ability of scFv-Fc antibody fragments

실시예 3에서 선별된 scFv-파아지는 이후 콜로니를 진탕 배양하여 DNA를 얻은 다음 항체 가변영역에 대한 서열을 분석하였다. 이 중에서 아미노산 서열로서 중복된 클론을 제외하고 선정된 scFv-파아지를 후보 항체 동물 세포 주에서의 발현능력을 평가하기 위하여 scFv 항체 분절(scFv-Fc) 형태로 벡터에 클로닝하였다. 형질도입 시약(Transfection reagent)을 이용하여 CHO 세포에 형질 감염시켜 발현시킨 후 그 배양액을 이용하여 scFv-Fc 항체 분절의 SARS-CoV-2의 S 단백질 2종에 대한 결합 능력을 ELISA로 확인하였다. 간단하게는, ELISA 플레이트에 SARS-CoV-2 S 단백질들을 붙이고 발현된 항체 분절을 넣어주었다. 결합하지 않은 항체를 0.05% Tween 20가 포함된 PBS로 씻어낸 후 HRP(겨자무과산화효소, horseradish peroxidase)가 결합된 항-인간 IgG 항체를 이용하여 항원과 결합한 항체 분절들을 선별 및 평가하였다. The scFv-phage selected in Example 3 was then cultured with shaking to obtain DNA and then sequenced for the antibody variable region was analyzed. Among them, the selected scFv-phages were cloned into a vector in the form of an scFv antibody fragment (scFv-Fc) in order to evaluate the expression ability in the candidate antibody animal cell line, except for duplicated clones as amino acid sequences. CHO cells were transfected and expressed using a transfection reagent, and the ability of the scFv-Fc antibody fragment to bind to two S proteins of SARS-CoV-2 was confirmed by ELISA using the culture medium. Briefly, SARS-CoV-2 S proteins were attached to an ELISA plate and the expressed antibody fragment was added. After washing the unbound antibody with PBS containing 0.05% Tween 20, HRP (horseradish peroxidase)-conjugated anti-human IgG antibody was used to select and evaluate antigen-bound antibody fragments.

그 결과, 하기 표 3에서와 같이 다수의 항체 분절들이 SARS-CoV-2의 S 단백질들에 대해 특이적으로 결합하는 것을 확인하고, 양성 대조군 항체와 대비하여 상대적인 값으로 결합력을 표기하였다. 하기 표 3에서 양성 대조군 항체는 SARS-CoV-2 S 단백질에 강하게 결합한다고 알려진 항체이다(Xiaolong Tian et al., Emerg Microbes Infect. 2020 Feb 17;9(1):382-385). 하기 표 3에서 No.는 상기 표 1 및 표 2에 기재된 각 결합 분자의 No.와 동일한 결합 분자를 지칭한다.As a result, as shown in Table 3 below, it was confirmed that a number of antibody fragments specifically bind to the S proteins of SARS-CoV-2, and the binding affinities are indicated as relative values compared to the positive control antibody. In Table 3 below, the positive control antibody is an antibody known to strongly bind to the SARS-CoV-2 S protein (Xiaolong Tian et al., Emerg Microbes Infect. 2020 Feb 17;9(1):382-385). No. in Table 3 below refers to the same binding molecule as No. of each binding molecule shown in Tables 1 and 2 above.

No.No. 결합력cohesion No.No. 결합력cohesion No.No. 결합력cohesion 1One 0.970.97 108108 1.821.82 243243 1.541.54 22 0.940.94 113113 1.441.44 244244 1.421.42 33 1.481.48 118118 1.361.36 245245 1.281.28 44 1.431.43 128128 1.401.40 246246 1.311.31 66 1.061.06 129129 1.421.42 247247 1.311.31 77 1.201.20 139139 1.361.36 249249 0.340.34 88 1.161.16 152152 1.181.18 250250 0.900.90 99 0.970.97 195195 0.140.14 251251 0.920.92 1313 1.171.17 196196 1.941.94 252252 0.940.94 1414 0.890.89 197197 2.092.09 254254 1.261.26 3131 1.351.35 201201 2.082.08 256256 0.470.47 4444 0.950.95 203203 1.061.06 259259 1.141.14 4646 1.601.60 204204 1.151.15 260260 0.810.81 4747 1.671.67 205205 1.231.23 261261 0.920.92 4848 1.171.17 206206 1.031.03 263263 1.461.46 4949 0.870.87 207207 1.261.26 265265 0.970.97 5353 1.041.04 208208 2.512.51 266266 0.800.80 5555 0.980.98 209209 1.431.43 268268 1.091.09 5656 1.231.23 212212 1.561.56 270270 0.950.95 6565 1.321.32 213213 1.701.70 271271 0.790.79 6666 1.751.75 214214 1.191.19 274274 1.011.01 6969 1.441.44 215215 1.121.12 275275 0.850.85 7070 1.341.34 216216 0.970.97 276276 1.001.00 7171 1.201.20 217217 1.471.47 278278 0.700.70 7272 0.650.65 218218 1.131.13 279279 0.570.57 7979 1.161.16 219219 1.291.29 280280 1.321.32 8181 1.631.63 220220 1.661.66 281281 1.361.36 8383 1.141.14 221221 1.231.23 283283 0.380.38 8686 1.411.41 224224 0.790.79 284284 1.081.08 8888 1.591.59 230230 1.031.03 285285 1.251.25 8989 1.371.37 232232 1.011.01 287287 0.800.80 9090 1.471.47 235235 1.251.25 288288 0.270.27 9191 1.291.29 236236 1.501.50 289289 1.081.08 9393 2.862.86 239239 1.451.45 290290 0.750.75 9595 2.292.29 241241 1.391.39 양성 대조군 항체positive control antibody 1.001.00 103103 1.131.13 242242 1.471.47

실시예 5. 완전 인간 항체(Full IgG)로 전환 후 항체 발현율 및 항체 결합 특이성 평가Example 5. Evaluation of antibody expression rate and antibody binding specificity after conversion to full human antibody (Full IgG)

선정된 항체 분절의 유전정보를 이용하여 완전 인간 항체로 변환하고, 실시예 4의 방법으로 항체 배양액을 준비하여, 완전 인간 항체에서의 항원 결합 및 항체 발현량 등을 확인하였다. 상기 바이러스 중화능 평가 결과와 종합하여 106종 중 23종의 완전 인간항체를 선별하였다. 선별된 23종의 완전 인간 항체의 발현량은 하기 표 4와 같다.The genetic information of the selected antibody fragment was converted into a fully human antibody, and an antibody culture medium was prepared according to the method of Example 4, and the antigen binding and antibody expression levels in the fully human antibody were confirmed. By combining the results of the evaluation of the virus neutralizing ability, 23 types of fully human antibodies out of 106 types were selected. The expression levels of the selected 23 kinds of fully human antibodies are shown in Table 4 below.

No. No. ug/ml ug/ml No. No. ug/ml ug/ml 8989 42.442.4 152152 15.215.2 9090 39.139.1 217217 35.735.7 9191 37.937.9 218218 5.85.8 9393 66.166.1 230230 15.915.9 9595 30.030.0 260260 19.719.7 103103 48.348.3 270270 53.853.8 108108 22.022.0 271271 28.828.8 113113 61.361.3 274274 7.07.0 118118 58.558.5 275275 30.730.7 128128 49.649.6 281281 34.934.9 129129 20.420.4 284284 54.654.6 139139 65.165.1

실시예 6-1. No. 139 항체의 SARS-CoV-2 슈도변이바이러스에 대한 중화능 평가(1)Example 6-1. No. Evaluation of neutralizing ability of 139 antibody against SARS-CoV-2 pseudo mutant virus (1)

SARS-CoV-2 spike D614와 D614G 및 제작한 SARS-CoV-2 spike 변이 슈도바이러스에 대해 No. 139 항체의 중화능 여부를 확인하는 시험을 진행하였다. 상기 SARS-CoV-2 spike 변이 슈도 바이러스는 No. 139 항체의 에피토프(실시예 8-5의 표 12 참조) 중 일부 위치와 논문(A. Baum et al., Science, 2020 Aug 21;369(6506):1014-1018., Korber et al., 2020, Cell 182, 812-827)에 발표된 변이 바이러스를 참고하여 제작하였다. 변이슈도바이러스의 양을 1.73ⅹ107 copies로 고정하고, 항체 100 ng/mL 최고 농도로 3배씩 10단계로 희석하여 변이바이러스에 대한 중화능 시험을 수행한 결과, 하기 표 5와 같이 중화능이 확인되었다.SARS-CoV-2 spike D614 and D614G and the prepared SARS-CoV-2 spike mutant pseudovirus No. A test was carried out to determine whether the neutralizing ability of the 139 antibody was performed. The SARS-CoV-2 spike mutant pseudovirus was No. Some positions of the epitope of the 139 antibody (see Table 12 in Examples 8-5) and the article (A. Baum et al., Science, 2020 Aug 21;369(6506):1014-1018., Korber et al., 2020 , Cell 182, 812-827) was prepared with reference to the published mutant virus. The amount of mutated pseudovirus was fixed at 1.73×10 7 copies, and the neutralizing ability was confirmed as shown in Table 5 below by diluting the antibody 100 ng/mL to the highest concentration in 10 steps and diluting it in 10 steps. .

하기 표 5에서, 각 변이 위치는 코로나바이러스 스파이크 단백질 (NCBI ACCESSION 번호: YP_009724390.1, 서열번호 2321)의 N 말단부터 넘버링(numbering) 한 것이다. In Table 5 below, each mutation position is numbered from the N-terminus of the coronavirus spike protein (NCBI ACCESSION number: YP_009724390.1, SEQ ID NO: 2321).

No.No. SARS-CoV-2 변이 pseudovirusSARS-CoV-2 mutant pseudovirus Backbone VectorBackbone Vector IC50 (ng/mL)IC50 (ng/mL) 1One D614D614 -- 0.3780.378 22 S494PS494P D614D614 -- 33 R685HR685H D614D614 0.4420.442 44 S494P+R685HS494P+R685H D614D614 -- 55 E484KE484K D614D614 3.2733.273 66 Q493KQ493K D614D614 -- 77 F490SF490S D614D614 0.8730.873 88 Y449NY449N D614D614 8.5568.556 99 L455FL455F D614D614 10.4910.49 1010 F456LF456L D614D614 0.3420.342 1111 L452RL452R D614D614 13.2213.22 1212 E406QE406Q D614D614 1.5211.521 1313 K444QK444Q D614D614 0.3970.397 1414 V445AV445A D614D614 0.6760.676 1515 N234QN234Q D614D614 0.5940.594 1616 A475VA475V D614D614 0.2430.243 1717 D614GD614G -- 0.3520.352 1818 S477NS477N D614GD614G 0.3620.362 1919 A222VA222V D614GD614G 0.410.41 2020 V1176FV1176F D614GD614G 0.3190.319 2121 N439KN439K D614GD614G 0.3320.332 2222 Y453FY453F D614GD614G 0.2270.227

실시예 6-2. No. 139 항체의 SARS-CoV-2 슈도변이바이러스에 대한 중화능 평가(2)Example 6-2. No. Evaluation of neutralizing ability of 139 antibody against SARS-CoV-2 pseudo mutant virus (2)

SARS-CoV-2의 변이 슈도 바이러스 15종에 대해 No. 139 항체의 중화능 여부를 확인하는 시험을 진행하였다. 여기서, 상기 No. 139 항체는 표 1 및 표 2에 기재된 No. 139 결합 분자를 지칭한다. 상기 SARS-CoV-2 spike 변이 슈도바이러스는 No. 139 항체(CT-P59, Regdanvimab)의 에피토프 중 일부 위치와 논문(A. Baum et al.,Science, 2020 Aug 21;369(6506):1014-1018, Korber et al., 2020, Cell 182, 812-827)에 발표된 변이 바이러스를 참고하여 제작하였다. 슈도변이바이러스의 양을 1.73ⅹ107 copies로 고정하고, 항체 1000 ng/mL 최고 농도로 3배씩 10단계로 희석하여 변이바이러스에 대한 중화능 시험을 수행한 결과, 하기 표 6과 같이 중화능이 확인되었다.No. 15 strains of SARS-CoV-2 mutated pseudoviruses. A test was carried out to determine whether the neutralizing ability of the 139 antibody was performed. Here, the No. 139 antibody was No. 1 and Table 2 listed. 139 refers to a binding molecule. The SARS-CoV-2 spike mutated pseudovirus was No. Some positions of epitopes of antibody 139 (CT-P59, Regdanvimab) and papers (A. Baum et al., Science, 2020 Aug 21;369(6506):1014-1018, Korber et al., 2020, Cell 182, 812 -827), referring to the mutated virus. The amount of pseudo mutant virus was fixed at 1.73×10 7 copies, and the neutralizing ability was confirmed as shown in Table 6 below by diluting the antibody to the highest concentration of 1000 ng/mL in 10 steps. .

하기 표 6에서, 각 변이 위치는 코로나바이러스 스파이크 단백질 (NCBI ACCESSION 번호: YP_009724390.1, 서열번호 2321) 의 N 말단부터 넘버링(numbering) 한 것이다. In Table 6 below, each mutation position is numbered from the N-terminus of the coronavirus spike protein (NCBI ACCESSION number: YP_009724390.1, SEQ ID NO: 2321).

No.No. SARS-CoV-2 변이 pseudovirusSARS-CoV-2 mutant pseudovirus IC50 (ng/ml)IC50 (ng/ml) 1One D614GD614G 1010 22 K417N+E484K+N501YK417N+E484K+N501Y 840840 33 501Y.V2501Y.V2 330330 44 D614D614 0.350.35 55 K417NK417N 0.250.25 66 E484KE484K 3.273.27 77 L452RL452R 13.2213.22 88 Y449NY449N 8.568.56 99 L455FL455F 10.4910.49 1010 F456LF456L 0.340.34 1111 Q493KQ493K >100>100 1212 S494PS494P >500>500 1313 E406QE406Q 1.521.52 1414 F490S F490S 0.870.87 1515 K417TK417T 0.150.15

실시예 6-3. No. 139 항체의 SARS-CoV-2 슈도변이바이러스에 대한 중화능 평가(3)Example 6-3. No. Evaluation of neutralizing ability of 139 antibody against SARS-CoV-2 pseudo mutant virus (3)

SARS-CoV-2 spike D614G 그리고 제작한 SARS-CoV-2 spike 변이 슈도바이러스에 대해 No. 139 항체의 중화능 여부를 확인하는 시험을 진행하였다. 상기 SARS-CoV-2 spike 변이 슈도 바이러스는 No. 139 항체의 에피토프(실시예 8-5의 표 12 참조) 중 일부 위치와 논문(A. Baum et al., Science, 2020 Aug 21;369(6506):1014-1018., Korber et al., 2020, Cell 182, 812-827., Wang et al.,2021, doi: 10.1038/s41586-021-03398-2.)에 발표된 변이 바이러스를 참고하여 제작하였다. 변이슈도바이러스의 양을 1.73ⅹ107 copies로 고정하고, 항체 100 ng/mL 최고 농도로 3배씩 10단계로 희석하여 변이바이러스에 대한 중화능 시험을 수행한 결과, 하기 표 7과 같이 중화능이 확인되었다.SARS-CoV-2 spike D614G and the prepared SARS-CoV-2 spike mutant pseudovirus No. A test was carried out to determine whether the neutralizing ability of the 139 antibody was performed. The SARS-CoV-2 spike mutant pseudovirus was No. Some positions of the epitope of the 139 antibody (see Table 12 in Examples 8-5) and the article (A. Baum et al., Science, 2020 Aug 21;369(6506):1014-1018., Korber et al., 2020 , Cell 182, 812-827., Wang et al., 2021, doi: 10.1038/s41586-021-03398-2.) was prepared with reference to the mutated virus. The amount of the mutant pseudovirus was fixed at 1.73×10 7 copies, and the neutralizing ability test was performed on the mutant virus by diluting 3 times to the highest antibody concentration of 100 ng/mL in 10 steps. As a result, the neutralizing ability was confirmed as shown in Table 7 below. .

하기 표 7에서, 각 변이 위치는 코로나바이러스 스파이크 단백질 (NCBI ACCESSION 번호: YP_009724390.1, 서열번호 2321) 의 N 말단부터 넘버링(numbering) 한 것이다. 또한, 영국 501Y.V1 (B.1.1.7) 변이, 남아공501Y.V2 (B.1.351) 변이, 브라질 변이 501Y.V3 (P.1), 캘리포니아 변이 (B.1.429), 뉴욕 변이 (B.1.525) 및 뉴욕 변이 (B.1.526)의 위치는 각각 하기 참고 표 A에 나타낸 바와 같다.In Table 7 below, each mutation position is numbered from the N-terminus of the coronavirus spike protein (NCBI ACCESSION number: YP_009724390.1, SEQ ID NO: 2321). Also, UK 501Y.V1 (B.1.1.7) mutation, South African 501Y.V2 (B.1.351) mutation, Brazil 501Y.V3 (P.1), California mutation (B.1.429), New York mutation (B. 1.525) and the New York variant (B.1.526) are respectively as shown in Reference Table A below.

No.No. SARS-CoV-2 변이 pseudovirusSARS-CoV-2 mutant pseudovirus Backbone VectorBackbone Vector IC50 (ng/ml)IC50 (ng/ml) 1One D614D614 -- 0.5350.535 22 D614GD614G -- 0.2190.219 33 Q493RQ493R D614GD614G -- 44 K417EK417E D614GD614G 0.1560.156 55 G446VG446V D614GD614G 0.4570.457 66 G476SG476S D614GD614G 0.3740.374 77 F486VF486V D614GD614G 9.99.9 88 E406WE406W D614GD614G 3.0063.006 99 N440DN440D D614GD614G 0.3980.398 1010 P681HP681H D614GD614G 0.3920.392 1111 K417NK417N D614GD614G 0.1860.186 1212 A701VA701V D614GD614G 0.3810.381 1313 D80AD80A D614GD614G 0.3720.372 1414 K417N+E484K+N501YK417N+E484K+N501Y D614GD614G 36.5936.59 1515 Q493MQ493M D614GD614G 0.830.83 1616 F486IF486I D614GD614G 4.4854.485 1717 Y489HY489H D614GD614G 0.4340.434 1818 N501YN501Y D614GD614G 1.2021.202 1919 HV69-70 delHV69-70del D614GD614G 0.2680.268 2020 HV69-70del + N501YHV69-70del + N501Y D614GD614G 0.5330.533 2121 N501TN501T D614GD614G 0.2280.228 2222 N501FN501F D614GD614G 1.0441.044 2323 Q677HQ677H D614GD614G 0.2260.226 2424 Q498HQ498H D614GD614G 0.6940.694 2525 N460TN460T D614GD614G 0.2550.255 2626 F486SF486S D614GD614G 0.6080.608 2727 F486LF486L D614GD614G 0.7920.792 2828 T478KT478K D614GD614G 0.2130.213 2929 K417TK417T D614GD614G 0.1540.154 3030 Q493YQ493Y D614GD614G 0.270.27 3131 Q493AQ493A D614GD614G 1.3521.352 3232 A372VA372V D614GD614G 0.3050.305 3333 P384LP384L D614GD614G 0.370.37 3434 S494LS494L D614GD614G -- 3535 501Y.V3 (P.1)501Y.V3 (P.1) D614GD614G 13.4513.45 3636 501Y.V2 (B.1.351)501Y.V2 (B.1.351) D614GD614G 40.3640.36 3737 B.1.526B.1.526 D614GD614G 1.4971.497 3838 E484Q+L452R+P681RE484Q+L452R+P681R D614GD614G 11.0811.08 3939 영국 (B.1.1.7)UK (B.1.1.7) D614GD614G 0.3580.358 4040 캘리포니아 (B.1.429)California (B.1.429) D614GD614G 8.78.7 4141 뉴욕 (B.1.525)New York (B.1.525) D614GD614G 1.5811.581 4242 S477RS477R D614GD614G 4.1264.126 4343 D420ND420N D614GD614G 0.5920.592 4444 Y473FY473F D614GD614G 0.40.4 4545 S494QS494Q D614GD614G 153.4153.4 4646 E484GE484G D614GD614G 0.5640.564 4747 S477NS477N D614GD614G 0.3890.389 4848 S494PS494P D614GD614G -- 4949 Y453FY453F D614GD614G 0.180.18 5050 N439KN439K D614GD614G 0.2770.277 5151 A222VA222V D614GD614G 0.2440.244 5252 N234QN234Q D614GD614G 0.3860.386

(참고 표 A)(Reference Table A)

Figure pat00019
Figure pat00019

실시예 7. 동물실험을 통한 No. 139 항체(Full IgG)의 SARS-CoV-2 바이러스 중화능 평가Example 7. No. through animal testing. Evaluation of SARS-CoV-2 virus neutralizing ability of 139 antibody (Full IgG)

실시예 7-1. 페렛 중화능 평가 실험Example 7-1. Ferret neutralizing ability evaluation experiment

SARS-CoV-2 바이러스에 자연 감염되며 인간과 유사한 임상 증상 및 병변을 보이는 동물 모델인 페렛을 이용하여, No. 139 항체의 생체 내 중화능을 평가하기 위하여 다음과 같이 실험을 진행하였다. Using ferret, an animal model naturally infected with SARS-CoV-2 virus and showing clinical symptoms and lesions similar to humans, No. In order to evaluate the in vivo neutralizing ability of the 139 antibody, the experiment was conducted as follows.

군 구성은 대조군 및 치료군(No. 139 항체 저용량 및 고용량 투여) 총 3군, 군당 5마리로 구성하였으며, SARS-CoV-2 바이러스(NMC-nCoV02) 1x105.5 TCID50/㎖을 비강과 기관지에 각 0.5mL씩 1mL을 접종하였다. 바이러스 접종 1일 후 SARS-CoV-2 바이러스와 무관한 isotype 대조군 항체 30 ㎎/㎏ 혹은 No. 139 항체 3 ㎎/㎏ 또는 30 ㎎/㎏을 단회 정맥 주사하고 7일동안 관찰하였다. 바이러스 감염 전 및 후 7일 동안 매일 각 군의 개체별 임상증상을 평가하였다. 바이러스 감염 후 2, 4, 6일째 각 군의 개체별 페렛 비강 세척액, 타액 및 직장 스왑 샘플을 채취하였으며, Vero 세포를 이용한 방법 및 qRT-PCR을 이용한 방법으로 바이러스 역가를 측정하였다. 또한, 조직 내 바이러스 역가를 평가하기 위해 3일째 각 군당 2마리의 페렛, 7일째 각 군당 3마리의 페렛을 희생시켜 비갑개 및 폐 조직을 확보하였고, 동일한 방법으로 바이러스 역가를 측정하였다.The group consisted of a control group and a treatment group (low dose and high dose administration of No. 139 antibody), a total of 3 groups and 5 animals per group. SARS-CoV-2 virus (NMC-nCoV02) 1x10 5.5 TCID 50 /ml was administered to the nasal passages and bronchial tubes, respectively. 1 mL of each 0.5 mL was inoculated. One day after virus inoculation, an isotype control antibody irrelevant to SARS-CoV-2 virus 30 mg/kg or No. A single intravenous injection of 3 mg/kg or 30 mg/kg of antibody 139 was observed for 7 days. Clinical symptoms were evaluated for each individual in each group every day for 7 days before and after viral infection. On days 2, 4, and 6 after virus infection, samples of ferret nasal lavage, saliva, and rectal swabs from each group were collected, and virus titers were measured by using Vero cells and by using qRT-PCR. In addition, in order to evaluate the viral titer in the tissue, 2 ferrets per group on the 3rd day and 3 ferrets in each group on the 7th day were sacrificed to obtain turbinate and lung tissues, and virus titers were measured in the same way.

그 결과, 하기 표 8에서와 같이, 임상증상에 있어서 모든 군에서 감염 후 2일째부터 기침, 콧물, 활동성 감소의 증상이 관찰되기 시작하였다. 대조군은 감염 후 3일과 4일째 가장 높은 임상 증상 척도를 보이며 시험 종료까지 콧물 및 활동성 감소를 보였다. 반면, No. 139 항체 저용량 및 고용량 투여군에서는 감염 후 2일째 대조군 대비 낮은 임상 증상(콧물, 활동성 감소) 척도가 관찰되었고 6일째에는 임상 증상이 관찰되지 않고 해소되었음을 확인하였다(표 8).As a result, as shown in Table 8 below, symptoms of cough, runny nose, and decreased activity began to be observed from the second day after infection in all groups in clinical symptoms. The control group showed the highest clinical symptom scale on the 3rd and 4th days after infection, and showed a runny nose and decreased activity until the end of the test. On the other hand, No. In the low-dose and high-dose administration groups of the 139 antibody, lower clinical symptoms (runny nose, decreased activity) were observed compared to the control group on the 2nd day after infection, and it was confirmed that the clinical symptoms were not observed and resolved on the 6th day (Table 8).

Figure pat00020
Figure pat00020

또한, Vero 세포를 이용하여 페렛의 비강 세척액 샘플 내 바이러스 역가를 측정한 결과, 도 1a에 나타낸 바와 같이, 감염 후 2일째 대조군 대비 No. 139 항체 고용량 투여군에서 바이러스 역가가 유의적으로 감소하였고, 6일째 바이러스가 측정되지 않았다 (도 1a).In addition, as a result of measuring the virus titer in the nasal lavage sample of the ferret using Vero cells, as shown in FIG. 1A , the No. The virus titer was significantly decreased in the 139 antibody high-dose administration group, and no virus was measured on day 6 ( FIG. 1A ).

qRT-PCR을 이용하여 페렛의 비강 세척액, 타액 및 직장 스왑 샘플 내 바이러스 역가를 측정한 결과, 도 1b에 나타낸 바와 같이, 감염 후 2일째 대조군과 비슷한 바이러스 역가를 보였으나 4일째 및 6일째 No. 139 항체 저용량 및 고용량 투여군에서 바이러스 역가가 감소하였다 (도 1b).As a result of measuring the viral titers in the nasal lavage, saliva and rectal swabs samples of ferrets using qRT-PCR, as shown in FIG. 1B , the virus titers were similar to those of the control group on the 2nd day after infection, but on the 4th and 6th days No. The virus titer was decreased in the low-dose and high-dose groups of the 139 antibody ( FIG. 1b ).

Vero 세포를 이용하여 페렛의 비갑개 조직 내 바이러스 역가를 측정한 결과, 도 1c에 나타낸 바와 같이, 대조군 대비 No. 139 항체 저용량 투여군에서 감염 후 3일째 바이러스 역가가 감소하였고, No. 139 항체 고용량 투여군에서는 감염 후 3, 7일째 바이러스 역가가 측정되지 않았다. 동일한 방법으로 폐 조직 내 바이러스 역가를 측정한 결과, No. 139 항체 저용량 투여군에서 감염 후 7일째, 고용량 투여군에서 감염 후 3일째 및 7일째 바이러스 역가가 측정되지 않았다 (도 1c).As a result of measuring the virus titer in the nasal turbinate tissue of the ferret using Vero cells, as shown in FIG. 1c , the No. In the low-dose 139 antibody-administered group, the virus titer decreased on the 3rd day after infection, and No. In the high-dose 139 antibody-administered group, virus titers were not measured on the 3rd and 7th days after infection. As a result of measuring the virus titer in the lung tissue in the same way, No. No virus titers were measured on the 7th day after infection in the low-dose administration group and on the 3rd and 7th days after infection in the high-dose administration group (Fig. 1c).

qRT-PCR을 이용하여 페렛의 비갑개 조직 내 바이러스 역가를 측정한 결과, 도 1d에 나타낸 바와 같이, 대조군 대비 No. 139 항체 저용량 및 고용량 투여군에서 감염 후 3일째 및 7일째 바이러스 역가가 감소하였다. 동일한 방법으로 폐 조직 내 바이러스 역가를 측정한 결과, No. 139 항체 저용량 투여군에서는 감염 후 3일째, No. 139 항체 고용량 투여군에서는 감염 후 3일째 및 7일째 바이러스 역가가 감소하였다 (도 1d).As a result of measuring the viral titer in the nasal turbinate tissue of the ferret using qRT-PCR, as shown in FIG. 1D, No. compared to the control group. The virus titers decreased on the 3rd and 7th days after infection in the low-dose and high-dose groups of the 139 antibody. As a result of measuring the virus titer in the lung tissue in the same way, No. 139 In the low-dose administration group, 3 days after infection, No. In the 139 antibody high-dose group, the virus titers decreased on the 3rd and 7th days after infection ( FIG. 1D ).

감염 3일째와 7일째, 부검 후 폐 조직을 현미경 관찰하였다. 바이러스 감염 후 3일째 페렛의 폐조직에서의 병리학적 분석 결과, 감염대조군에서는 폐조직 전반적으로 호중구 세포의 증가 및 폐포벽 두께증가의 염증소견이 확인되었고, No. 139 항체 저용량 투여군에서도 감염대조군보다는 적지만 염증소견이 보이는 곳이 확인되었으며, 고용량 투여군에서는 감염대조군 대비 확연하게 염증소견이 감소된 것을 확인하였다.On the 3rd and 7th days of infection, the lung tissue was observed under a microscope after autopsy. As a result of the pathological analysis in the lung tissue of ferrets on the 3rd day after virus infection, in the infected control group, inflammatory findings such as an increase in neutrophil cells and an increase in the thickness of the alveolar wall were confirmed throughout the lung tissue. In the low-dose administration group of the 139 antibody, although fewer than those in the infection control group, inflammatory findings were confirmed, and in the high-dose administration group, it was confirmed that the inflammation was significantly reduced compared to the infection control group.

감염 후 7일째 페렛의 폐조직에서의 병리학적 분석 결과, 감염대조군에서는 감염 후 3일째보다 감소했지만 전반적으로 호중구 세포의 증가 및 폐포벽 두께증가의 염증소견이 유지되었고, No. 139 항체 저용량 및 고용량 투여군에서는 감염대조군보다는 확연하게 염증소견이 감소되었고 국소적인 부분에서만 염증소견이 관찰되었다 (도 2).As a result of the pathological analysis of the lung tissue of ferrets on the 7th day after infection, the infection control group showed a decrease compared to the 3rd day after infection, but overall, the inflammatory findings of the increase in neutrophil cells and the increase in the thickness of the alveolar wall were maintained. In the low-dose and high-dose administration groups of the 139 antibody, inflammatory findings were significantly reduced than in the infection control group, and inflammatory findings were observed only in local areas (FIG. 2).

실시예 7-2. 골든시리안햄스터 중화능 평가 실험Example 7-2. Golden Syrian Hamster Neutralization Power Evaluation Experiment

SARS-CoV-2 바이러스에 자연 감염되며 인간과 유사한 임상 증상 및 병변을 보이는 동물 모델인 골든시리안햄스터를 이용하여, No. 139 항체의 생체 내 중화능을 평가하기 위하여 다음과 같이 실험을 진행하였다. Using Golden Syrian Hamster, an animal model naturally infected with SARS-CoV-2 virus and showing clinical symptoms and lesions similar to humans, No. In order to evaluate the in vivo neutralizing ability of the 139 antibody, the experiment was conducted as follows.

군 구성은 대조군 및 치료군 (No. 139 항체 15mg/kg, 30mg/kg, 60 mg/kg 또는 90 mg/kg) 총 5군, 군당 12 마리로 구성하였으며, SARS-CoV-2 바이러스(NMC-nCoV02) 6.4 x 104 PFU/80 μL를 비강에 점종하였다. 바이러스 접종 1일 후 SARS-CoV-2 바이러스와 무관한 PBS 대조군, 혹은 No. 139 항체 15 ㎎/㎏, 30 mg/kg, 60 mg/kg 또는 90 ㎎/㎏을 단회 복강 주사하고 6일동안 관찰하였다. 추가적으로, 바이러스 감염 전 및 후 6일 동안 매일 각 군의 개체별 체중을 평가하였다. 조직 내 바이러스 역가를 측정하기 위해 바이러스 접종 후 2일째, 3일째 및 5일째 각 군당 4 마리를 희생시켜 폐, 비갑개 및 십이지장 조직을 확보하였고, qRT-PCR을 이용하여 폐, 비갑개 및 십이지장 바이러스 역가를 측정하였고, Vero 세포를 이용하여 폐 조직의 생바이러스 역가를 측정하였다.The group consisted of a total of 5 groups and 12 animals per group, including control and treatment groups (No. 139 antibody 15mg/kg, 30mg/kg, 60mg/kg or 90mg/kg), and SARS-CoV-2 virus (NMC-nCoV02) ) 6.4 x 10 4 PFU/80 μL was instilled into the nasal cavity. One day after virus inoculation, a PBS control unrelated to SARS-CoV-2 virus, or No. A single intraperitoneal injection of 139 antibody 15 mg/kg, 30 mg/kg, 60 mg/kg or 90 mg/kg was administered and observed for 6 days. Additionally, individual body weights of each group were evaluated before and after viral infection every day for 6 days. In order to measure the viral titer in the tissue, 4 animals from each group were sacrificed on the 2nd, 3rd, and 5th days after virus inoculation to obtain lung, turbinate and duodenal tissues. Lung, turbinate and duodenal virus titers were measured using qRT-PCR was measured, and the live virus titer of lung tissue was measured using Vero cells.

그 결과, 하기 도 3a 에서와 같이, 바이러스 감염으로 인한 체중감소는 군 간 별다른 차이가 나지 않았다 (도 3a). 또한, qRT-PCR을 이용하여 폐, 비갑개, 십이지장 바이러스 역가를 측정한 결과는 다음과 같다. 폐에서 90mg/kg 투여 시, 접종 후 3일차 사후 검정 결과, 대조군 대비 약 47배 감소하였고, 접종 후 5일차 사후 검정 결과, 30, 60, 90 mg/kg 투여 시, 대조군 대비 순서대로 22, 27, 197배 감소하였다 (도 3b). 비갑개에서 접종 후 2일차 사후 검정 결과, 30 mg/kg 투여 시, 대조군 대비 약 3배 감소하였고, 접종 후 5일차 사후 검정 결과, 15, 30, 60, 90mg/kg 투여 시, 대조군 대비 약 순서대로 11, 11, 16, 12 배 감소하였다 (도 3c). 십이지장에서 접종 후 2일차 사후 검정 결과, 대조군 대비 60, 90 mg/kg 투여 시, 접종 후 5일차 사후 검정 결과 60, 90 mg/kg 투여 시, 대조군과 비교하였을 때 통계적으로 유의한 차이가 나타났다 (도 3d).As a result, as shown in FIG. 3a below, there was no significant difference between the groups in weight loss due to viral infection ( FIG. 3a ). In addition, the results of measuring lung, turbinate, and duodenal virus titers using qRT-PCR are as follows. When 90 mg/kg was administered to the lungs, the result of the post-test on the 3rd day after inoculation decreased about 47-fold compared to the control group, and the results of the post-test on the 5th day after inoculation, when administered at 30, 60, and 90 mg/kg, 22, 27 compared to the control group in that order , decreased by 197 fold (Fig. 3b). As a result of the post-test on the 2nd day after inoculation in the nasal turbinate, when 30 mg/kg was administered, it decreased about 3 times compared to the control group, and on the 5th day after inoculation, when administered at 15, 30, 60, 90 mg/kg, in approximately order compared to the control group. 11, 11, 16, and 12 fold (Fig. 3c). As a result of post-test on the 2nd day after inoculation in the duodenum, when 60 and 90 mg/kg were administered compared to the control group, and when the post-test results on the 5th day after inoculation were administered at 60 and 90 mg/kg, there was a statistically significant difference compared to the control group ( Fig. 3d).

또한 Vero 세포를 이용하여 폐 조직 내 생바이러스 역가를 측정한 결과 도 3e에 나타낸 바와 같이, 대조군 대비 No. 139 항체 90 mg/kg 투여군 1마리를 제외하고는 60 mg/kg 및 90 mg/kg 투여군에서 감염 후 2일째부터 바이러스 역가가 측정되지 않았다. 15 mg/kg 투여군의 경우 2일째에는 바이러스 역가가 측정되지 않았지만, 3일째 및 5일째 한마리에서 바이러스 역가가 측정되었다. 30 mg/kg 투여군의 경우 3일째부터 바이러스 역가가 측정되지 않았다 (도 3e).In addition, as a result of measuring the live virus titer in the lung tissue using Vero cells, as shown in FIG. 3e, No. compared to the control group. Virus titers were not measured from the second day after infection in the 60 mg/kg and 90 mg/kg administration groups, except for one animal in the 139 antibody 90 mg/kg administration group. In the case of the 15 mg/kg administration group, the virus titer was not measured on the 2nd day, but the virus titer was measured in one rat on the 3rd and 5th days. In the case of the 30 mg/kg administration group, the virus titer was not measured from the third day ( FIG. 3E ).

실시예 7-3. 마우스 예방능 평가 실험Example 7-3. Mouse preventive ability evaluation experiment

SARS-CoV-2 바이러스에 자연 감염되며 인간과 유사한 임상 증상 및 병변을 보이는 동물 모델인 TG마우스(B6.Cg-Tg(K18-ACE2)2Prlmn/J [Stock No: 034860 | K18-hACE2] from The Jackson Laboratory)를 이용하여, No. 139 항체의 생체 내 예방능을 평가하기 위하여 다음과 같이 실험을 진행하였다. TG mouse (B6.Cg-Tg(K18-ACE2)2Prlmn/J [Stock No: 034860 | K18-hACE2] from The Jackson Laboratory), No. In order to evaluate the in vivo preventive ability of the 139 antibody, the experiment was conducted as follows.

군 구성은 대조군 및 투여군 (No. 139 항체 10 mg/kg, 1mg/kg, 0 mg/kg 또는 0.1 mg/kg) 총 5군, 각각 군당 5 마리 또는 6 마리로 구성하였으며, PBS 혹은 No. 139 항체 0.1 ㎎/㎏, 1 mg/kg, 또는 10 mg/kg 투여 후 24시간 뒤 SARS-CoV-2 바이러스(NMC-nCoV02) 1 x 105 PFU 60μL를 비강에 접종하여 최대 6일간 관찰하였다. 추가적으로, 바이러스 접종 전 및 후 6일 동안 매일 각 군의 개체별 체중을 평가하였다. 조직 내 바이러스 역가를 측정하기 위해 바이러스 접종 후 3일째와 6일째 마우스를 희생시켜 폐조직과 비강세척액을 확보하였고, Vero 세포를 이용한 플라크 분석 (Plaque assay)하여 각 조직의 바이러스 역가를 측정하였다.The group composition consisted of a total of 5 groups of control and administration groups (No. 139 antibody 10 mg/kg, 1 mg/kg, 0 mg/kg or 0.1 mg/kg), 5 or 6 animals per group, respectively, and PBS or No. 24 hours after administration of 139 antibody 0.1 mg/kg, 1 mg/kg, or 10 mg/kg, SARS-CoV-2 virus (NMC-nCoV02) 1 x 10 5 PFU 60 μL was inoculated into the nasal cavity and observed for up to 6 days. Additionally, body weights of individuals in each group were evaluated daily before and after virus inoculation for 6 days. To measure the virus titer in tissue, mice were sacrificed on the 3rd and 6th days after virus inoculation to obtain lung tissue and nasal wash, and the virus titer of each tissue was measured by plaque assay using Vero cells.

그 결과, 대조군에서 2개체가 바이러스 접종 후 2일째에 폐사하였고, 1개체가 6일째에 폐사하였으며, 0.1mg/kg 와 1 mg/kg 투여군에서 각각 1개체가 2일째에 폐사하였다. 초기 폐사(접종 후 2일째)의 경우 CNS에서의 hACE2 단백질 발현으로 인한 뇌염으로 의심되었다. As a result, two subjects in the control group died on the 2nd day after virus inoculation, one individual died on the 6th day, and one individual died on the second day in the 0.1 mg/kg and 1 mg/kg administration groups, respectively. In the case of early mortality (day 2 after inoculation), encephalitis due to hACE2 protein expression in the CNS was suspected.

바이러스 감염으로 인한 체중감소는 1 mg/kg 혹은 10 mg/kg 투여군에서 크게 감소하였다 (도 4a).Weight loss due to viral infection was significantly reduced in the 1 mg/kg or 10 mg/kg administration group (FIG. 4a).

또한, 플라크 분석으로 측정한 폐와 비강세척액의 바이러스 역가는 다음과 같다. 0.1, 1, 10mg/kg 투여 시, 접종 후 3일째 대조군 대비 폐 바이러스 역가가 순서대로 9배, 4,079배, 9,007배 감소하였다. 또한, 접종 후 6일째 대조군 대비 폐 바이러스 역가는 순서대로 25배, 478배, 29배 감소하였다 (도 4b).In addition, the viral titers of the lung and nasal lavage fluids measured by plaque assay were as follows. When administered at 0.1, 1, or 10 mg/kg, the lung virus titers were sequentially decreased 9-fold, 4,079-fold, and 9,007-fold compared to the control group on the 3rd day after inoculation. In addition, on the 6th day after inoculation, compared to the control group, lung virus titers were sequentially decreased 25-fold, 478-fold, and 29-fold ( FIG. 4b ).

0.1, 1, 10mg/kg 투여 시, 접종 후 3일째 대조군 대비 비강세척액에서 바이러스 역가가 순서대로 2배, 79배, 1304배 감소하였다. 또한, 접종 후 6일째 대조군 대비 바이러스 역가는 순서대로 1배, 63배, 10배 감소하였다 (도 4c).At the administration of 0.1, 1, and 10 mg/kg, the virus titer in the nasal wash solution was decreased by 2 times, 79 times, and 1304 times in the order of 3 days after inoculation compared to the control group. In addition, on the 6th day after inoculation, the virus titer was decreased by 1 fold, 63 fold, and 10 fold compared to the control group ( FIG. 4c ).

실시예 7-4. 남아공 변이 바이러스에 대한 페렛 중화능 평가 실험Example 7-4. Ferret neutralizing ability evaluation experiment for South African mutant virus

SARS-CoV-2 바이러스에 자연 감염되며 인간과 유사한 임상 증상 및 병변을 보이는 동물 모델인 페렛을 이용하여, No. 139 항체의 생체 내 중화능을 평가하기 위하여 다음과 같이 실험을 나누어서 진행하였다. 여기서, CT-P59 항체는 No. 139 항체를 지칭한다. Using ferret, an animal model naturally infected with SARS-CoV-2 virus and showing clinical symptoms and lesions similar to humans, No. In order to evaluate the in vivo neutralizing ability of the 139 antibody, the experiment was divided as follows. Here, the CT-P59 antibody is No. 139 antibody.

첫번째 시험의 경우, 군 구성은 대조군(부형제 투여) 및 치료군(No. 139 항체 80 mg/kg 또는 160 mg/kg 투여) 총 3군, 군당 6마리로 구성하였으며, 야생형(wild-type) SARS-CoV-2 바이러스(NMC-nCoV02;S-clade) 1x105.5 TCID50/㎖을 비강과 기관지에 각 0.5mL씩 총 1mL을 접종하였다. 부형제 혹은 No. 139 항체 80 mg/kg 또는 160 mg/kg를 바이러스 접종 후 24시간 후 단회 정맥 주사하였으며, 바이러스 접종 전 및 후 6일동안 임상증상 및 체중을 관찰하였다. 바이러스 감염 전(0 dpi) 및 후 2, 4, 6일째 (2,4,6 dpi) 각 군의 개체별 페렛 비강 세척액 샘플을 채취하였으며, Vero 세포를 이용한 방법 및 qRT-PCR을 이용한 방법으로 바이러스 역가를 측정하였다. 또한, 조직 내 바이러스 역가를 평가하기 위해 3일째와 6일째 군당 3마리의 페렛을 희생시켜 비갑개 및 폐 조직을 확보하였고, 동일한 방법으로 바이러스 역가를 측정하였다.For the first test, the group consisted of a control group (administration of excipient) and a treatment group (administration of 80 mg/kg or 160 mg/kg of No. 139 antibody), 6 animals per group, and wild-type SARS- CoV-2 virus (NMC-nCoV02;S-clade) 1x10 5.5 TCID 50 /ml was inoculated into the nasal passages and bronchial tubes, 0.5mL each, for a total of 1mL. Excipients or No. 139 antibody 80 mg/kg or 160 mg/kg was administered as a single intravenous injection 24 hours after virus inoculation, and clinical symptoms and body weight were observed before and 6 days after virus inoculation. Before (0 dpi) and on the 2nd, 4th, and 6th days (2,4,6 dpi) after virus infection, samples of ferret nasal lavage from each group were collected. Titers were measured. In addition, in order to evaluate the viral titer in the tissue, 3 ferrets per group were sacrificed on the 3rd and 6th days to obtain turbinate and lung tissues, and the virus titer was measured in the same way.

두 번째 시험의 경우, 군 구성은 대조군(부형제 투여) 및 치료군(No. 139 항체 80 mg/kg, 160 mg/kg 투여) 총 3군, 군당 6마리로 구성하였으며, SARS-CoV-2 남아공 변이 바이러스(B.1.351) 1x105.5 TCID50/㎖을 비강과 기관지에 각 0.5mL씩 총 1mL을 접종하였다. 부형제 혹은 No. 139 항체 80 mg/kg 또는 160 mg/kg를 바이러스 접종 후 24시간 후 단회 정맥 주사하였으며, 바이러스 접종 전 및 후 4일동안 임상증상 및 체중을 관찰하였다. 바이러스 감염 전 및 감염 후 2일째 및 4일째 각 군의 개체별 페렛 비강 세척액 샘플을 채취하였으며, Vero 세포를 이용한 방법 및 qRT-PCR을 이용한 방법으로 바이러스 역가를 측정하였다. 또한, 조직 내 바이러스 역가를 평가하기 위해 2일과 4일째 각 군당 3마리의 페렛을 희생시켜 비갑개 및 폐 조직을 확보하였고, 동일한 방법으로 바이러스 역가를 측정하였다.In the case of the second test, the group consisted of a control group (excipient administration) and a treatment group (administration of No. 139 antibody 80 mg/kg, 160 mg/kg), total of 3 groups, 6 animals per group, and SARS-CoV-2 South African mutation Virus (B.1.351) 1x10 5.5 TCID 50 /ml was inoculated into the nasal passages and bronchial tubes, 0.5mL each, for a total of 1mL. Excipients or No. 139 antibody 80 mg/kg or 160 mg/kg was administered as a single intravenous injection 24 hours after virus inoculation, and clinical symptoms and body weight were observed before and 4 days after virus inoculation. Feret nasal lavage samples were collected from each group before and on the 2nd and 4th days after infection, and virus titers were measured by using Vero cells and by using qRT-PCR. In addition, in order to evaluate the viral titer in the tissue, 3 ferrets were sacrificed in each group on the 2nd and 4th days to secure the turbinate and lung tissue, and the virus titer was measured in the same way.

그 결과, 하기 표 9와 표 10 에서와 같이, 임상증상에 있어서 SARS-CoV-2 wild-type 혹은 B.1.351을 접종한 모든 군에서 감염 후 2일째부터 기침, 콧물, 활동성 감소 중 하나 이상의 증상이 관찰되기 시작하였다. 대조군은 wild-type 감염의 경우에는 3일째, B.1.351 감염의 경우에는 2일째 가장 높은 임상 증상 척도를 보이며 시험 종료까지 콧물 및 활동성 감소를 보였다. 반면에, No. 139 항체 투여군에서는 모든 군에서 감염 후 2일째부터 대조군 대비 낮은 임상 증상 척도가 관찰되었고, wild-type 감염군의 경우에는 4일째부터 모든 투여 군에서 임상증상이 나타나지 않았으며, B.1.351 감염군의 경우에는 4일째 160 mg/kg 그룹에서 한 마리를 제외한 모든 개체에서 임상 증상이 관찰되지 않고 해소되었음을 확인하였다 (표 9 및 표 10).As a result, the following Table 9 and Table 10 As in the case of clinical symptoms, one or more of cough, runny nose, and decreased activity began to be observed from the 2nd day after infection in all groups inoculated with SARS-CoV-2 wild-type or B.1.351. The control group showed the highest clinical symptom scale on the 3rd day in the case of wild-type infection and on the 2nd day in the case of B.1.351 infection, and showed a runny nose and decreased activity until the end of the test. On the other hand, No. In the 139 antibody-administered group, lower clinical symptom scales were observed compared to the control group from the 2nd day after infection in all groups. In this case, it was confirmed that clinical symptoms were not observed and resolved in all but one animal in the 160 mg/kg group on the 4th day (Tables 9 and 10).

Figure pat00021
Figure pat00021

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Figure pat00022

도 5a 에서와 같이, 바이러스 감염으로 인한 체중감소는 160 mg/kg 투여군과 대조군 사이에서 Wild-type SARS-CoV-2 감염 후 3일째, 160 mg/kg 투여군과 대조군 사이에서 SARS-CoV-2 변이주(B.1.351) 2일 째 및 80 mg/kg 투여군과 대조군 사이에서 2,3 및4일째 유의성 있는 차이를 보였다 (도 5a). 도 5a의 그래프 내 80 mg/kg 와 대조군 사이의 차이는 *로, 160 mg/kg 와 대조군 사이의 차이는 #으로 표시하였다. As shown in FIG. 5a , weight loss due to virus infection was observed on the 3rd day after wild-type SARS-CoV-2 infection between the 160 mg/kg administration group and the control group, and between the 160 mg/kg administration group and the control group, the SARS-CoV-2 mutant strain. (B.1.351) On the 2nd day and between the 80 mg/kg administration group and the control group, there was a significant difference on the 2nd, 3rd and 4th days (FIG. 5a). In the graph of FIG. 5A , the difference between 80 mg/kg and the control is indicated by *, and the difference between 160 mg/kg and the control is indicated by #.

또한, Vero 세포를 이용하여 페렛의 비강 세척액, 비갑개 및 폐 샘플 내 생바이러스 역가를 측정한 결과, 도 5b 에 나타낸 바와 같이, Wild-type SARS-CoV-2 감염 후 2일째부터 대조군 대비 No. 139 항체 투여군에서 비강세척액의 바이러스 역가가 유의적으로 감소하였고, 비갑개에서 3일째부터 감소하였다. 폐에서는 3일째부터 투여군의 바이러스 역가가 정량한계까지 감소하였으며 대조군과 비교하여 유의적인 차이를 보였다. 6일째에는 대조군과 치료군이 유의한 차이를 보이지 않았다. SARS-CoV-2 변이주 (B.1.351) 감염 후 2일째부터 대조군 대비 No. 139 항체 투여군의 비강세척액과 비갑개의 바이러스 역가가 유의적으로 감소하였다. 투여군의 폐 바이러스 역가의 경우. 2일째부터 정량한계에 도달하였으며 대조군 대비 유의적인 감소를 보였고, 4일째 대조군과 치료군의 모든 개체에서 바이러스가 확인되지 않았다(도 5b).In addition, as a result of measuring the live virus titers in the nasal lavage, nasal turbinate, and lung samples of ferret using Vero cells, as shown in FIG. In the 139 antibody-administered group, the viral titer of the nasal wash was significantly decreased, and decreased from the 3rd day in the turbinate. In the lungs, the virus titer of the administration group decreased to the limit of quantitation from the third day, and there was a significant difference compared with the control group. On the 6th day, there was no significant difference between the control group and the treatment group. SARS-CoV-2 mutant strain (B.1.351) from the 2nd day after infection, No. The viral titers of nasal lavage and turbinate were significantly decreased in the 139 antibody-treated group. For lung virus titers in the administration group. The limit of quantitation was reached from the 2nd day, and there was a significant decrease compared to the control group, and on the 4th day, no virus was identified in all subjects in the control group and the treatment group (FIG. 5b).

qRT-PCR을 이용하여 페렛의 비강 세척액, 비갑개 및 폐 샘플 내 바이러스 역가를 측정한 결과, 도 5c에 나타낸 바와 같이, Wild-type SARS-CoV-2 감염 후 비강세척액에서 2, 4 및 6일째 No. 139 항체 투여군과 대조군 사이에서 유의적인 바이러스 역가 차이가 확인되었으며, 투여군의 경우 80 mg/kg 군의 한마리를 제외한 동물에서 감염 후 2일째부터 바이러스 역가가 정량한계까지 감소하였다. 비갑개와 폐에서는 3일부터 바이러스 역가가 정량한계까지 감소하였으며, 대조군 대비 유의한 차이를 보였다. SARS-CoV-2 변이주 (B.1.351) 감염 후에도, 2일째부터 No. 139 항체 투여군에서 비강세척액, 비갑개 및 폐에서의 바이러스 역가가 대조군 대비 유의적으로 감소하였다. 폐의 경우 4일째 대조군과 치료군의 바이러스 역가가 정량한계까지 감소하였다 (도 5c).As a result of measuring virus titers in nasal lavage, nasal turbinate, and lung samples of ferrets using qRT-PCR, as shown in FIG. 5c, No. 2, 4, and 6 days . A significant difference in virus titer was confirmed between the 139 antibody-administered group and the control group, and in the case of the administration group, the virus titer decreased to the limit of quantitation from the second day after infection in animals except for one animal in the 80 mg/kg group. In the turbinate and lung, virus titers decreased to the limit of quantitation from day 3, and there was a significant difference compared to the control group. After infection with the SARS-CoV-2 mutant (B.1.351), No. In the 139 antibody-administered group, the viral titers in nasal lavage, nasal turbinate and lung were significantly reduced compared to the control group. In the case of lung, the virus titers of the control group and the treatment group decreased to the limit of quantitation on day 4 (FIG. 5c).

실시예 7-5. 브라질 변이 바이러스에 대한 마우스 중화능 평가 실험Example 7-5. Mouse neutralizing ability test for Brazilian mutant virus

SARS-CoV-2 바이러스에 자연 감염되며 인간과 유사한 임상 증상 및 병변을 보이는 동물 모델인 TG마우스(Tg(K18-ACE2)2Prlmn from The Jackson Laboratory)를 이용하여, No. 139 항체의 생체 내 중화능을 평가하기 위하여 다음과 같이 실험을 진행하였다. 여기서, CT-P59 항체는 No. 139 항체를 지칭한다. Using a TG mouse (Tg(K18-ACE2)2Prlmn from The Jackson Laboratory), an animal model naturally infected with SARS-CoV-2 virus and exhibiting clinical symptoms and lesions similar to humans, No. In order to evaluate the in vivo neutralizing ability of the 139 antibody, the experiment was conducted as follows. Here, the CT-P59 antibody is No. 139 antibody.

군 구성은 대조군 및 투여군 (No. 139 항체 5, 20, 40 또는 80 mg/kg) 총 5군, 각각 군당 11마리, 총 55마리로 구성하였으며, 브라질 변이 (P.1; 감마) SARS-CoV-2 바이러스 1x104 PFU 30 μL를 비강에 접종하였다. 바이러스 접종 8시간 후 부형제 혹은 No. 139 항체 5, 20, 40 또는 80 mg/kg를 단회 복강 주사하였으며, 바이러스 접종 전 후 10일 동안 체중을 평가하고 생존 여부를 관찰하였다. 조직 내 바이러스 역가를 측정하기 위해 바이러스 접종 후 3일째와 6일째 마우스를 각각 4마리씩 희생시켜 폐 조직과 비강세척액을 확보하였고, Vero 세포를 이용한 플라크 분석 (Plaque assay)을 하여 각 샘플의 바이러스 역가를 측정하였다.The group composition consisted of a total of 5 groups of control and administration groups (No. 139 antibody 5, 20, 40, or 80 mg/kg), 11 animals per group, and 55 mice in total. Brazil mutant (P.1; gamma) SARS-CoV -2 Virus 1x10 4 PFU 30 μL was inoculated into the nasal cavity. 8 hours after virus inoculation, excipient or No. A single intraperitoneal injection of 5, 20, 40 or 80 mg/kg of the 139 antibody was performed, and body weight was evaluated for 10 days before and after virus inoculation and survival was observed. In order to measure the viral titer in the tissue, 4 mice were sacrificed on the 3rd and 6th days after virus inoculation to obtain lung tissue and nasal lavage fluid. Plaque assay using Vero cells was performed to determine the virus titer of each sample. measured.

그 결과, 대조군의 2개체가 바이러스 접종 후 7일째에 30% 이상의 체중 감소율을 보여 폐사로 간주하였고, 1개체가 8일째에 폐사하며 8일째부터 0%의 생존율을 보였다. 반면 No.139 항체 투여군에서는 폐사 개체 또는 30% 이상의 체중 감소율을 보이는 개체가 확인되지 않았으며, 생존율 100%로 기록되었다.As a result, 2 subjects in the control group showed a weight loss of 30% or more on the 7th day after virus inoculation, and were considered dead, and 1 subject died on the 8th day and showed a survival rate of 0% from the 8th day. On the other hand, in the No.139 antibody-administered group, no mortality or weight loss of 30% or more was identified, and the survival rate was recorded as 100%.

바이러스로 접종 후 1일째부터 대조군 개체들의 체중 감소가 보이기 시작하였으며, 6일째에는 평균 27.3%의 체중 감소율을 보였다. No.139 항체를 5, 20, 40 또는 80 mg/kg 투여 시, 바이러스 접종 후 6일째의 평균 체중 감소율은 순서대로 18.8%, 16.6%, 16.7%, 9.2% 였으며, 바이러스 접종 후 3일째부터 6일째까지 대조군 대비 평균 체중 감소가 유의적으로 방어되는 것으로 나타났다. 이 후 항체 투여군의 동물들은 바이러스 접종 10일째까지, 체중을 회복하는 경향을 보였다 (도 6a).The weight loss of the control subjects started to be seen from the 1st day after inoculation with the virus, and on the 6th day, the average weight loss rate was 27.3%. When No.139 antibody was administered at 5, 20, 40, or 80 mg/kg, the average weight loss rate on the 6th day after virus inoculation was 18.8%, 16.6%, 16.7%, and 9.2%, in that order, from the 3rd day after the virus inoculation to 6 It was found that the mean weight loss compared to the control group was significantly protected until the first day. Thereafter, the animals of the antibody-administered group showed a tendency to recover body weight until the 10th day of virus inoculation (FIG. 6a).

플라크 분석으로 측정한 폐 조직에서의 바이러스 역가는 다음과 같다. No.139 항체를 5, 20, 40 또는 80 mg/kg 투여 시, 접종 후 3일째 대조군 대비 폐 바이러스 역가가 순서대로 9.2, 5.5, 2.5, 3.6배 감소하였다. 또한, No.139 항체 투여군에서는 접종 후 6일째에 바이러스가 검출되지 않으며 대조군 대비 유의한 효과를 보였다 (도 6b).Virus titers in lung tissue as determined by plaque assay were as follows. When the No.139 antibody was administered at 5, 20, 40, or 80 mg/kg, the lung virus titer was decreased by 9.2, 5.5, 2.5, and 3.6 times compared to the control group on the 3rd day after inoculation, in that order. In addition, in the No.139 antibody-administered group, no virus was detected on the 6th day after inoculation, and a significant effect was observed compared to the control group ( FIG. 6b ).

플라크 분석으로 측정한 비강세척액에서의 바이러스 역가는 다음과 같다. 바이러스 접종 후 3일째와 6일째에 대조군의 각각 한 개체에서 2와 2.3 log10 (PFU+1)/mL의 바이러스 역가를 보이며 평균 0.5와 0.6 log10 (PFU+1)/mL의 역가를 나타내었다. 반면 No.139 항체 투여군에서는 접종 후 3일째와 6일째에 바이러스가 검출되지 않으며 바이러스 역가 감소 효과를 보였다 (도 6c).The virus titers in the nasal wash as determined by plaque assay were as follows. On the 3rd and 6th days after virus inoculation, one individual in the control group showed viral titers of 2 and 2.3 log 10 (PFU+1)/mL, with an average titer of 0.5 and 0.6 log 10 (PFU+1)/mL. . On the other hand, in the No.139 antibody-administered group, no virus was detected on the 3rd and 6th days after inoculation, and the virus titer decreased ( FIG. 6c ).

실시예 8. No. 139 항체(Full IgG)의 SARS-CoV-2 스파이크 단백질의 리셉터 결합 도메인(RBD)과의 결합부위 결정Example 8. No. Determination of binding site of 139 antibody (Full IgG) with receptor binding domain (RBD) of SARS-CoV-2 spike protein

본 발명의 No. 139 항체(Full IgG)가 SARS-CoV-2 RBD에 결합하는 부위를 결정하기 위하여 X선 회절분석법을 이용하여 항체 분절이 RBD 단백질 상에 결합하는 아미노산 서열을 분석하였다(도 7a). 그 결과 No. 139 항체 에피토프의 주요 구성 요소는 RBD 공간 구조 위에 파란색으로 표기를 하였고 각 아미노산 위치도 표시하였다(도 7d).No. of the present invention. In order to determine the site where the 139 antibody (Full IgG) binds to SARS-CoV-2 RBD, the amino acid sequence of the antibody fragment binding on the RBD protein was analyzed using X-ray diffraction (FIG. 7a). As a result, No. The major components of the 139 antibody epitope are marked in blue on the RBD spatial structure, and each amino acid position is also indicated ( FIG. 7d ).

실시예 8-1. 재조합 SARS-CoV-2 RBD 단백질의 발현Example 8-1. Expression of Recombinant SARS-CoV-2 RBD Protein

X선 회절 분석에 사용하기 위한 재조합 SARS-CoV-2 RBD 단백질을 생산하기 위하여 'Wuhan-Hu-1'(BetaCoV/Wuhan-Hu-1/2019) 코로나바이러스 스파이크 단백질 (NCBI ACCESSION 번호: YP_009724390.1, 서열번호: 2321) 의 RBD 부분 (아미노산 잔기 319번에서 536번)에 C말단 부위에 8개의 히스티딘 잔기를 추가한 DNA 서열을 MarEx 벡터에 클로닝하였다.'Wuhan-Hu-1' (BetaCoV/Wuhan-Hu-1/2019) coronavirus spike protein (NCBI ACCESSION number: YP_009724390.1) to produce recombinant SARS-CoV-2 RBD protein for use in X-ray diffraction analysis , SEQ ID NO: 2321) of the RBD portion (amino acid residues 319 to 536), a DNA sequence in which 8 histidine residues were added to the C-terminal region was cloned into MarEx vector.

상기 발현 벡터를 Lipofectamine LTX (Invitrogen) 를 이용하여 CHO 세포에 트랜스펙션(transfection) 하고, SFM4CHO 무혈청 배지 (HyClone) 및 400 nM methotrexate (MTX; Yuhan) 하에서 선별하였다. SARS-CoV-2 RBD 단백질을 안정적으로 발현하는 클론을 선정하여 유가식 배양을 통해 SARS-CoV-2 RBD 단백질을 대량 생산하였다. 구체적으로, SFM4CHO를 기본 배지로 하여 배양 3, 5 및 7일 시점에 BalanCD CHO Feed 4 배지 (Irvine) 및 글루코스를 첨가하고, 배양 9일째 원심분리하여 배양액을 회수하였다. The expression vector was transfected into CHO cells using Lipofectamine LTX (Invitrogen), and selected under SFM4CHO serum-free medium (HyClone) and 400 nM methotrexate (MTX; Yuhan). A clone stably expressing the SARS-CoV-2 RBD protein was selected and the SARS-CoV-2 RBD protein was mass-produced through fed-batch culture. Specifically, BalanCD CHO Feed 4 medium (Irvine) and glucose were added at 3, 5 and 7 days of culture using SFM4CHO as a basal medium, and the culture medium was recovered by centrifugation on the 9th day of culture.

Metal affinity chromatography (Ni-NTA agarose column; Qiagen Cat No. 30210) 방법으로 배양액 내의 SARS-CoV-2 RBD 단백질을 정제하였다. 정제된 RBD는 VIVASPIN 30 Membrane 5,000 MWCO PES (Sartorius, Cat No.VS2012) 을 사용하여 10 mM Tris-HCl (pH8.0), 150 mM NaCl 버퍼로 8.3 mg/ml 농도로 RBD를 농축하였다.The SARS-CoV-2 RBD protein in the culture medium was purified by metal affinity chromatography (Ni-NTA agarose column; Qiagen Cat No. 30210). Purified RBD was concentrated using VIVASPIN 30 Membrane 5,000 MWCO PES (Sartorius, Cat No. VS2012) to a concentration of 8.3 mg/ml with 10 mM Tris-HCl (pH 8.0) and 150 mM NaCl buffer.

실시예 8-2. 항체 분절의 정제Example 8-2. Purification of antibody fragments

No. 139 항체를 정제수를 이용하여 2.0 mg/mL 농도로 희석을 한 다음 2X digestin 버퍼 (200mM Tris-HCl (pH 7.4), 4mM EDTA) 와 최종 1mM L-cysteine 을 첨가하여 Papain (Roche, REF#:10108014001)과 100:1의 비율로 혼합한 후 37℃에서 1시간동안 효소반응을 진행하였다. 이 후 Antipain dihydrochloride (Sigma, Cat. No.11004646001) 1mg/mL 을 100: 1 비율로 추가하고 다시 37℃에서 45분간 반응을 시켰다. No. 139 antibody was diluted to 2.0 mg/mL with purified water, and then Papain (Roche, REF#:10108014001) was added with 2X digestin buffer (200mM Tris-HCl (pH 7.4), 4mM EDTA) and final 1mM L-cysteine. ) and 100:1 ratio, followed by enzymatic reaction at 37°C for 1 hour. After that, 1 mg/mL of Antipain dihydrochloride (Sigma, Cat. No. 11004646001) was added at a ratio of 100: 1 and reacted again at 37°C for 45 minutes.

반응액은 Mabselect SuRe column (GE Healthcare Cat No. 17-5438-03)을 이용하여 Fab과 Fc 부분을 분리함으로써 Fc를 제거하고, VIVASPIN 30 Membrane 5,000 MWCO PES (Sartorius, Cat No.VS2012) 을 사용하여 10 mM Tris-HCl (pH 8.0), 150 mM NaCl 버퍼로 14.2 mg/ml 농도로 No. 139 Fab 분절을 농축하였다. The reaction solution removes Fc by separating the Fab and Fc parts using Mabselect SuRe column (GE Healthcare Cat No. 17-5438-03), and VIVASPIN 30 Membrane 5,000 MWCO PES (Sartorius, Cat No. VS2012) using 10 mM Tris-HCl (pH 8.0), 150 mM NaCl buffer at a concentration of 14.2 mg/ml No. The 139 Fab fragment was concentrated.

실시예 8-3. 항체 분절과 SARS-CoV-2 RBD 단백질의 동시-결정화 Example 8-3. Co-crystallization of antibody fragments and SARS-CoV-2 RBD protein

No. 139 항체의 Fab 분절과 SARS-CoV-2 RBD 복합체를 만들기 위해 정제된 RBD 와 No. 139 Fab 을 1:1.2 몰비율로 혼합하였다. 여분의 No. 139 Fab은 10mM 10mM Tris-HCl (pH 8.0), 150mM NaCl 버퍼를 이용하여 HiLoad 16/600 Superdex 200 (GE Healthcare: 28989335)을 평형화 시킨 다음 결합하고 있지 않는 여분의 No. 139 Fab 을 제거하였다. No. 139 Fab/ RBD 복합체는 6mg/mL으로 농축을 하고 결정화에 이용하였다. No. 139 antibody Fab fragment and purified RBD and No. 139 Fab was mixed in a molar ratio of 1:1.2. extra No. The 139 Fab was prepared by equilibrating HiLoad 16/600 Superdex 200 (GE Healthcare: 28989335) with 10 mM 10 mM Tris-HCl (pH 8.0) and 150 mM NaCl buffer, and then equilibrating the excess No. 139 Fab was removed. No. The 139 Fab/RBD complex was concentrated to 6 mg/mL and used for crystallization.

X-선 회절분석이 가능한 결정은 20℃에서 부유 방울 증기 확산법을 이용하여 0.4 uL의 No. 139 Fab/RBD 복합체와 동일한 부피의 10 mM NiCl2, 0.1 M Tris-HCl (pH 8.0) and 16% (wt/vol) PEG MME 2000 조성의 침전용액을 혼합한 조건에서 일주일 동안 결정 최적화를 진행하였다. Crystals capable of X-ray diffraction analysis were prepared by using the floating droplet vapor diffusion method at 20 °C with 0.4 uL of No. Crystal optimization was carried out for one week under the condition of mixing the same volume of the 139 Fab/RBD complex with a precipitation solution of 10 mM NiCl 2 , 0.1 M Tris-HCl (pH 8.0) and 16% (wt/vol) PEG MME 2000 composition. .

실시예 8-4. X선 회절 분석법 Example 8-4. X-ray diffraction analysis

X-선 데이터 수집을 위해 20% ethylene glycol 을 첨가한 동일한 침전용액에 결정을 담갔다가 100캘빈 질소 가스 스트림에 넣었다. X-선 회절 데이터 세트는 2.71

Figure pat00023
해상도로 대한민국 포항 가속기 연구소 (PAL: Pohang Accelerator Laboratory) 빔라인 BL-5C 에서 수집하였다. 데이터 세트는 XDS 프로그램 패키지로 처리를 하였고, No. 139 Fab/ RBD 복합체는 I222 체심사방정계로 결정화되었다. No. 139 Fab/ RBD 복합체 구조는 Phaser 프로그램의 몰레큘라 리플레이스먼트(Molecular Replacement) 방법으로 결정하였다. 몰레큘라 리플레이스먼트(Molecular Replacement) 진행 시 SARS-CoV-2 RBD/CB6 복합 구조(PDB코드, 7C01)를 검색 모델로 사용하였고, 모델 구축은 Coot 프로그램으로 진행하였다. 모델 전반에 걸쳐 2Fo-Fc 전자 밀도는 잘 정의되었고 구조의 정교화 및 보정은 Penix 패키지를 사용하여 수행하였다. X-선 회절 및 구조 보정 통계는 표 11에 기록을 하였다 (데이터 수집과 보정 통계).For X-ray data collection, crystals were immersed in the same precipitation solution with 20% ethylene glycol added, and then placed in a 100 Kelvin nitrogen gas stream. The X-ray diffraction data set is 2.71
Figure pat00023
The resolution was collected at the Pohang Accelerator Laboratory (PAL) beamline BL-5C in Korea. The data set was processed with the XDS program package, and No. The 139 Fab/RBD complex was crystallized in an I222 body cubic system. No. The structure of the 139 Fab/RBD complex was determined by the Molecular Replacement method of the Phaser program. In the case of molecular replacement, the SARS-CoV-2 RBD/CB6 complex structure (PDB code, 7C01) was used as a search model, and the model construction was performed with the Coot program. The 2F o -F c electron density was well defined throughout the model, and the elaboration and correction of the structure was performed using the Penix package. X-ray diffraction and structural correction statistics are reported in Table 11 (data collection and correction statistics).

Figure pat00024
Figure pat00024

실시예 8-5: 구조 데이터의 평가와 분석Example 8-5: Evaluation and Analysis of Structural Data

No. 139 Fab/ SARS-CoV-2 RBD 복합체 구조에서 No. 139 Fab는 ACE2가 SARS-CoV-2 RBD 와 직접 결합하고 있는 수용체 결합 모티프에 결합한다. CCP4i 패키지의 Contact 프로그램을 이용하여 Van der Waals 결합의 거리 컷 오프를 4.5

Figure pat00025
으로 하고 수소결합 거리 컷 오프를 3.5
Figure pat00026
으로 하여 에피토프(epitope) 분석을 진행하였다. No. 139 항체의 중쇄와 경쇄 부분에서 RBD와 상호결합하는 부위는 각각 용매 접근 표면적 824.2
Figure pat00027
2과 112.5
Figure pat00028
2 표면 부위를 각각 감싸고 있다. 대부분의 상호 작용은 중쇄의 3개의 상보성결정부위 (CDR: complementarity-determining region) 부분의 아미노산 잔기 16개와 RBD의 19개 아미노산 잔기를 통해 결합하고 있고, 경쇄의 경우 CDR1, CDR2 의 3개 잔기가 RBD 4개 잔기와 결합하고 있음을 보여 주었다. 특히 중쇄 CDR3 의 beta-hairpin 구조는 ACE2 결합 RBD 표면 (도 8)의 중간에 여러 방향족 아미노산을 포함하고 있는 소수성 상호 작용뿐만 아니라 8개의 수소 결합을 형성함으로써 RBD 와 강하게 결합하는데 결정적인 역할을 하고 있다. 구조 데이터 분석을 통한 에피토프(EPITOPE) 와 파라토프(PARATOPE) 정보는 표 12 에 기재하였다. 표 12에서, SARS-CoV-2 RBD 에피토프(EPITOPE) 아미노산 위치는 SARS-CoV-2의 스파이크 단백질(NCBI Accession No. YP_009724390.1, 서열번호: 2321)의 N 말단부터 numbering 한 것이다(signal peptide 부터 시작하여 numbering함). 표 12에서, No. 139의 Heavy Chain, Light Chain의 파라토프(PARATOPE) 아미노산 위치는 No. 139 항체의 중쇄, 경쇄 가변부 서열의 N 말단부터 numbering 한 것이다(즉, No. 139 항체의 중쇄, 경쇄 가변부 서열의 N 말단에서 첫번째 아미노산을 1로 함).No. In the structure of the 139 Fab/SARS-CoV-2 RBD complex, No. 139 Fab binds to a receptor binding motif in which ACE2 directly binds to SARS-CoV-2 RBD. Using the Contact program in the CCP4i package, the distance cutoff of the Van der Waals bond was set to 4.5.
Figure pat00025
and set the hydrogen bond distance cutoff to 3.5
Figure pat00026
As a result, epitope analysis was performed. No. 139 RBD-interacting sites in the heavy and light chain regions of the antibody have a solvent access surface area of 824.2, respectively.
Figure pat00027
2 and 112.5
Figure pat00028
Each of the 2 surface areas is covered. Most of the interactions are bound through 16 amino acid residues of the three complementarity-determining region (CDR) regions of the heavy chain and 19 amino acid residues of the RBD, and in the case of the light chain, the three residues of CDR1 and CDR2 are RBD It was shown to bind to 4 residues. In particular, the beta-hairpin structure of the heavy chain CDR3 plays a decisive role in strong binding to the RBD by forming 8 hydrogen bonds as well as hydrophobic interactions involving several aromatic amino acids in the middle of the ACE2-binding RBD surface (Fig. 8). Epitope (EPITOPE) and paratope (PARATOPE) information through structural data analysis is described in Table 12. In Table 12, the SARS-CoV-2 RBD epitope (EPITOPE) amino acid positions are numbered from the N-terminus of the SARS-CoV-2 spike protein (NCBI Accession No. YP_009724390.1, SEQ ID NO: 2321) (from signal peptide) start with numbering). In Table 12, No. Paratope amino acid position of Heavy Chain and Light Chain of 139 is No. It is numbered from the N terminus of the heavy and light chain variable region sequences of the antibody 139 (that is, the first amino acid at the N terminus of the heavy and light chain variable region sequences of the No. 139 antibody is set to 1).

No. 139 항체가 SARS-CoV-2 RBD 와 ACE2 결합을 방해함으로서 바이러스가 세포에 감염되는 것을 막는 것을 구조에 기초하여 분석을 진행하였다. SARS-CoV-2 RBD / ACE2 단백질 복합체 구조 (PDB코드, 6LZG)는 도 7b에 표현하였고, ACE2 의 RBD 결합하는 공간적인 위치는 도 7e에서 확인 할 수 있다. No. 139 항체가 RBD에 결합함으로 인해서 RBD 자체의 콘포메이션(conformation)의 변화를 보여주지는 않고 있음을 두 개의 RBD 구조에서 193개의 alpha 탄소 사이의 상호 루트 평균 제곱 편차가 0.89

Figure pat00029
으로 확인할 수 있었다. 하지만 beta 5번 체인과 6번 사이의 루프 부위 (아미노산 473-488)는 No. 139 항체가 결합으로 인해 국소 변화가 있었다. SARS-CoV-2 RBD 와 ACE2 의 자세한 결합 위치는 표 13에 기재하였다((Wang Q, et al., (2020) Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2. Cell 10.1016/j.cell.2020.03.045). SARS-CoV-2 RBD / No. 139 와 SARS-CoV-2 RBD / ACE2 를 슈퍼임포즈 (superimpose) 한 그림은 도 7c에 나타내었다. 공간적인 슈퍼임포즈 그림에서 보이는 바와 같이 No. 139 의 중쇄는 ACE2 위치와 완전히 오버랩 (overlap) 되는 것을 볼 수 있고, 경쇄는 추가적으로 일부 RBD 와 결합하는 것을 볼 수 있다. 도 7d와 도 7e에서는 각 결합부위를 RBD 상에 표현하였고, ACE2 와 No. 139 가 동시에 결합하고 있는 아미노산 잔기는 빨간색 글자로 표기하였다. 이 두 그림 (도 7d 및 7e) 에서 보는 바와 같이 ACE2 와 결합하는 21개 아미노산 잔기 중 12개가 No. 139 항체가 동일하게 결합하는 것을 확인할 수 있으며, No. 139 항체는 RBD 상에 ACE2가 결합하는 중앙 부위에 골고루 분포를 하고 있음을 확인하였다. 이들을 종합해 보았을 때, SARS-CoV-2 RBD의 No. 139 항체의 에피토프는 ACE2 와 RBD 결합을 완전히 저해하는 에피토프로 볼 수 있다.No. The analysis was carried out based on the structure of the 139 antibody preventing virus infecting cells by interfering with SARS-CoV-2 RBD and ACE2 binding. The structure of the SARS-CoV-2 RBD / ACE2 protein complex (PDB code, 6LZG) is shown in FIG. 7b, and the spatial location of ACE2 binding to RBD can be confirmed in FIG. 7e. No. The mutual root mean square deviation between the 193 alpha carbons in the two RBD structures was 0.89, indicating that the 139 antibody did not show a change in the conformation of the RBD itself due to binding to the RBD.
Figure pat00029
could be confirmed with However, the loop region between beta 5 and 6 (amino acids 473-488) is No. There were local changes due to 139 antibody binding. Detailed binding sites of SARS-CoV-2 RBD and ACE2 are described in Table 13 ((Wang Q, et al., (2020) Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2. Cell 10.1016/j) .cell.2020.03.045), SARS-CoV-2 RBD / No. 139 and SARS-CoV-2 RBD / ACE2 superimposed are shown in Fig. 7c. As can be seen, it can be seen that the heavy chain of No. 139 completely overlaps with the ACE2 position, and the light chain additionally binds to some RBD. In Figures 7d and 7e, each binding site is expressed on the RBD. The amino acid residues to which ACE2 and No. 139 are simultaneously bound are indicated in red letters, as shown in these two figures (Figs. 7d and 7e), 12 out of 21 amino acid residues that bind to ACE2 are No. 139 antibody. It can be confirmed that the binding is the same, and it was confirmed that the No. 139 antibody is evenly distributed in the central region where ACE2 binds on the RBD. Taken together, the No. 139 antibody of SARS-CoV-2 RBD The epitope can be viewed as an epitope that completely inhibits ACE2 and RBD binding.

하기 표 12에서No. 139 에피토프(EPITOPE) 및 파라토프(PARATOPE) 정보를, 하기 표 13에서 SARS-CoV-2 RBD 와 상호결합하는 ACE2 아미노산 잔기를 나타내었다.In Table 12 below, No. 139 Epitope (EPITOPE) and paratope (PARATOPE) information, the following Table 13 shows the ACE2 amino acid residues that cross-binding SARS-CoV-2 RBD.

Figure pat00030
Figure pat00030

Figure pat00031
Figure pat00031

실시예 9. 표면 플라스몬 공명 기술을 이용한 항원-항체 친화도 결정Example 9. Determination of antigen-antibody affinity using surface plasmon resonance technology

표면 플라스몬 공명(Surface Plasmon Resonance) 검정은 정반응 속도 상수 및 역반응 속도 상수의 역학적 측정에 의해 항체의 결합친화도를 결정한다.The Surface Plasmon Resonance assay determines the binding affinity of an antibody by kinetic measurements of forward and reverse rate constants.

정제된 재조합 SARS-CoV-2-RBD 단백질에 대한 No. 139 항체의 결합은 25°C에서 실행 완충액 HBS-EP (10 mM HEPES [pH 7.4], 150 mM NaCl, 3 mM EDTA 및 0.005% 계면활성제 P20)을 사용하는 Biacore T200 장비로 표면플라스몬 공명-기본 측정에 의해 결정되었다. 10 mM 아세트산나트륨 (Sodium Acetate, pH 5.0) 중에 희석된 약 150 RU의 SARS-CoV-2-RBD 단백질을 8 ㎍/ml로 제조사의 지침 및 절차에 따라 표준 아민 커플링 키트(Amine coupling kit)를 사용하여 CM5 연구용 바이오센서 칩에 직접적으로 고정시켰다. 바이오센서 표면에서 반응하지 않은 부분을 에탄올아민(ethanolamine)으로 차단하였다. 반응 분석을 위해 Biacore T200 콘트롤 소프트웨어, Biacore T200 이벨루에이션 소프트웨어를 사용하였다. No. 139 항체는 HBS-EP 완충액에 희석하여 20 ㎕/분의 유속으로 반응 매트릭스상에 주입하였다. 검정 동안에, 모든 측정은 포획된 재조합 SARS-CoV-2-RBD 단백질이 없는 포획 표면을 대조군으로 사용하였다. 결합 및 분리 속도 상수 Ka (M-1s-1) 및 Kd (s-1)은 20 ㎕/분의 유속에서 3배의 희석 시리즈로서 0.04 내지 10 nM 범위의 상이한 항원 농도에서 반응 결합 측정을 실시함으로써 획득하였다. 이어서, 항체와 표적 항원 사이의 반응에 대한 평형 해리 상수 KD (M)를 반응 속도 상수로부터 다음의 등식에 의해 계산하였다: KD = Kd/Ka. 결합은 시간과 반응 속도 상수의 함수를 계산하여 기록한다. No. for purified recombinant SARS-CoV-2-RBD protein. Binding of the 139 antibody was surface plasmon resonance-based with a Biacore T200 instrument using running buffer HBS-EP (10 mM HEPES [pH 7.4], 150 mM NaCl, 3 mM EDTA and 0.005% surfactant P20) at 25 °C. was determined by measurement. Approximately 150 RU of SARS-CoV-2-RBD protein diluted in 10 mM sodium acetate (Sodium Acetate, pH 5.0) at 8 µg/ml was prepared using a standard amine coupling kit according to the manufacturer's instructions and procedures. was used and directly immobilized on the CM5 research biosensor chip. The unreacted portion on the biosensor surface was blocked with ethanolamine. For reaction analysis, Biacore T200 control software and Biacore T200 evolution software were used. No. The 139 antibody was diluted in HBS-EP buffer and injected onto the reaction matrix at a flow rate of 20 μl/min. During the assay, all measurements used the capture surface free of captured recombinant SARS-CoV-2-RBD protein as a control. Binding and dissociation rate constants Ka (M −1 s −1 ) and Kd (s −1 ) are a series of three-fold dilutions at a flow rate of 20 μl/min. Reaction binding measurements are performed at different antigen concentrations ranging from 0.04 to 10 nM. was obtained by The equilibrium dissociation constant KD (M) for the reaction between the antibody and the target antigen was then calculated from the reaction rate constant by the following equation: KD = Kd/Ka. Binding is recorded as a function of time and reaction rate constants.

정제된 다양한 재조합 SARS-CoV-2-RBD 단백질에 대한 No. 139 항체의 결합친화도를 결정하였다(표 14 및 도 9). No. 139 항체는 SARS-CoV-2-RBD 항원에 대하여 높은 결합친화도를 나타내었다.No. 5 for various purified recombinant SARS-CoV-2-RBD proteins. The binding affinity of the 139 antibody was determined (Table 14 and FIG. 9). No. Antibody 139 showed high binding affinity to the SARS-CoV-2-RBD antigen.

하기 표 14에서 SARS-CoV-2-RBD 단백질에 대한 No. 139 항체의 결합친화도 측정 결과를 나타내었다.No. for SARS-CoV-2-RBD protein in Table 14 below. The binding affinity measurement results of the 139 antibody are shown.

No.No. Ka (M-1s-1)Ka (M-1s-1) Kd(s-1)Kd(s-1) KD(M)KD(M) AverageAverage No. 139No. 139 7 Х 106 7 Х 10 6 1.58 Х 10-4 1.58 Х 10 -4 2.26 Х 10-11 2.26 Х 10 -11 2.71 Х 10-11 2.71 Х 10 -11 6.77 Х 106 6.77 Х 10 6 2.14 Х 10-4 2.14 Х 10 -4 3.16 Х 10-11 3.16 Х 10 -11

실시예 10. No. 139 항체(Full IgG)의 물리화학적 특성 분석Example 10. No. Physicochemical characterization of 139 antibody (Full IgG)

바이러스 중화능 측정 결과를 기반으로 가장 중화능이 크고, 생산 수율이 우수한 후보 1종을 선정하고, 물리화학적 특성 분석을 진행하였다 (표 15). Based on the virus neutralizing ability measurement result, one candidate with the greatest neutralizing ability and excellent production yield was selected, and physicochemical characteristics were analyzed (Table 15).

크기 배제 크로마토그래피법(Size Exclusion Chromatography, SEC-HPLC)을 이용하여, 항체의 비정상적인 파편 (Fragment, LMW)나 응집 (Aggregation, HMW)의 발생 유무를 평가하였다. 이런 비정상적인 단백질 구조는 본래 항체가 가지고 있는 항원 특이적인 결합능, 생체 내 약물동력학에 영향을 주기 때문에, 일반적인 항체 제조 방법의 우월성을 간접적으로 확인할 수 있다. 선정된 NO. 139는 99.87% 이상의 정상 항체 구조의 비율을 보였으며, 이 수치는 상업시판 중인 단일클론 항체와 비교하여 동등 이상의 품질을 보여 주고 있다 (도 10). Size exclusion chromatography (SEC-HPLC) was used to evaluate whether abnormal fragments (LMW) or aggregation (HMW) of the antibody occurred. Since this abnormal protein structure affects the antigen-specific binding ability and in vivo pharmacokinetics of the original antibody, the superiority of the general antibody manufacturing method can be indirectly confirmed. Selected NO. 139 showed a ratio of the normal antibody structure of 99.87% or more, and this figure shows the quality equal to or higher than that of a commercially available monoclonal antibody (FIG. 10).

모세관 전기영동 분석 (Capillary Electrophoresis, CE)을 통해서 비환원 조건 (Non-reduced condition)에서의 Intact IgG의 순도 비율과, 환원 조건 (Reduced condition)에서의 항체 중쇄/경쇄합 비율 (Sum of Heavy & Light Chain)을 평가하였다 (도 11). 선정된 NO. 139는 비환원 조건에서 Intact IgG의 비율은 89%, 환원조건에서 항체 중쇄/경쇄합 비율은 99%를 보였으며, 이 수치는 상업시판 중인 단일클론 항체와 비교하여 동등 이상의 품질을 보여 주고 있다.Through capillary electrophoresis (CE), the purity ratio of Intact IgG in a non-reduced condition and the antibody heavy chain/light chain combination ratio in a reduced condition (Sum of Heavy & Light) Chain) was evaluated ( FIG. 11 ). Selected NO. 139 showed an Intact IgG ratio of 89% under non-reducing conditions and 99% of antibody heavy/light chain combination ratio under reducing conditions.

하기 표 15에서 NO. 139 항체의 물리화학적 특성 분석 결과를 나타내었다.In Table 15 below, NO. The results of physicochemical characterization of the 139 antibody are shown.

평가 방법Assessment Methods 결과result SEC-HPLCSEC-HPLC Monomer (%)Monomer (%) 99.87%99.87% High Molecular Weight (HMW) (%)High Molecular Weight (HMW) (%) 0.07%0.07% Low Molecular Weight (LMW) (%)Low Molecular Weight (LMW) (%) 0.06%0.06% Non-reduced CE-SDSNon-reduced CE-SDS Intact IgG (%)Intact IgG (%) 89%89% Reduced CE-SDSReduced CE-SDS Sum of Heavy & Light Chain (%)Sum of Heavy & Light Chain (%) 99%99%

실시예 11. No. 139 항체(Full IgG)의 항체 결합 특성 및 작용 기전 평가Example 11. No. Evaluation of antibody binding properties and mechanism of action of 139 antibody (Full IgG)

실시예 5를 통하여 선정된 No. 139 항체(Full IgG)의 결합 특이성을 Octet 분석을 진행하여 평가하였다. No. selected through Example 5. The binding specificity of the 139 antibody (Full IgG) was evaluated by performing Octet analysis.

분석 결과, 도 12과 같이 SARS-CoV-2 바이러스에 대한 특이적인 결합능력이 확인되었다. 하기 도 12에서 SARS-CoV S1, HCoV-HKU1 S1 및 MERS-CoV RBD는 각각 사스, 일반 감기 및 메르스의 원인이 되는 바이러스의 표면 단백질을 지칭한다.As a result of the analysis, specific binding ability to SARS-CoV-2 virus was confirmed as shown in FIG. 12 . In FIG. 12, SARS-CoV S1, HCoV-HKU1 S1 and MERS-CoV RBD refer to surface proteins of viruses that cause SARS, the common cold, and MERS, respectively.

SARS-CoV-2 바이러스는 표면 단백질 (RBD)를 인간 수용체 (ACE2)에 결합시켜 인체 세포에의 감염을 시작할 수 있다. 그러므로, No. 139 항체(Full IgG)의 작용 기전 (mechanism of action)을 Octet을 이용하여 Biolayer interference (BLI) 분석을 진행하여 평가하였다. 분석 결과, 하기 표 16과 같이 SARS-CoV-2 바이러스 표면 단백질 (RBD)의 변이 단백질에 대해서도 우수한 결합력을 가지며, 도 13와 같이 SARS-CoV-2 표면 단백질 (RBD)와 인간 수용체 (ACE2)의 결합이 No. 139 항체(Full IgG)에 의해 완전하게 억제되는 것이 확인되었다. SARS-CoV-2 virus can initiate infection into human cells by binding surface protein (RBD) to human receptor (ACE2). Therefore, No. The mechanism of action of the 139 antibody (Full IgG) was evaluated by performing Biolayer interference (BLI) analysis using Octet. As a result of the analysis, as shown in Table 16 below, the SARS-CoV-2 virus surface protein (RBD) mutant protein had excellent binding affinity, and as shown in FIG. 13 , the SARS-CoV-2 surface protein (RBD) and human receptor (ACE2) The bond is No. It was confirmed that it was completely inhibited by the 139 antibody (Full IgG).

하기 표 16에서, 각 변이 위치는 코로나바이러스 스파이크 단백질 (NCBI ACCESSION 번호: YP_009724390.1, 서열번호 2321) 의 N 말단부터 넘버링(numbering) 한 것이다.In Table 16 below, each mutation position is numbered from the N-terminus of the coronavirus spike protein (NCBI ACCESSION No.: YP_009724390.1, SEQ ID NO: 2321).

No.No. RBD mutantRBD mutants KK DD (M) (M) 1One P337SP337S 7.68 Х 10-11 (WT: 5.99 Х 10-11)7.68 Х 10 -11 (WT: 5.99 Х 10 -11 ) 22 G446SG446S 6.11 Х 10-11 (WT: 7.25 Х 10-11)6.11 Х 10 -11 (WT: 7.25 Х 10 -11 ) 33 F338LF338L 6.04 Х 10-11 (WT: 5.99 Х 10-11)6.04 Х 10 -11 (WT: 5.99 Х 10 -11 ) 44 L452RL452R 4.71 Х 10-10 (WT: 5.10 Х 10-11)4.71 Х 10 -10 (WT: 5.10 Х 10 -11 ) 55 V341IV341I 5.75 Х 10-11 (WT: 3.95 Х 10-11)5.75 Х 10 -11 (WT: 3.95 Х 10 -11 ) 66 Y453FY453F 7.24 Х 10-11 (WT: 9.33 Х 10-11)7.24 Х 10 -11 (WT: 9.33 Х 10 -11 ) 77 F342LF342L 5.76 Х 10-11 (WT: 4.72 Х 10-11)5.76 Х 10 -11 (WT: 4.72 Х 10 -11 ) 88 F456LF456L 7.57 Х 10-11 (WT: 7.25 Х 10-11)7.57 Х 10 -11 (WT: 7.25 Х 10 -11 ) 99 A344SA344S 7.43 Х 10-11 (WT: 5.99 Х 10-11)7.43 Х 10 -11 (WT: 5.99 Х 10 -11 ) 1010 K458RK458R 4.25 Х 10-11 (WT: 4.72 Х 10-11)4.25 Х 10 -11 (WT: 4.72 Х 10 -11 ) 1111 A348SA348S 6.24 Х 10-11 (WT: 5.99 Х 10-11)6.24 Х 10 -11 (WT: 5.99 Х 10 -11 ) 1212 E471QE471Q 5.84 Х 10-11 (WT: 3.95 Х 10-11)5.84 Х 10 -11 (WT: 3.95 Х 10 -11 ) 1313 A352SA352S 9.94 Х 10-11 (WT: 1.02 Х 10-10)9.94 Х 10 -11 (WT: 1.02 Х 10 -10 ) 1414 I472VI472V 4.97 Х 10-11 (WT: 3.95 Х 10-11)4.97 Х 10 -11 (WT: 3.95 Х 10 -11 ) 1515 N354DN354D 5.33 Х 10-11 (WT: 4.72 Х 10-11)5.33 Х 10 -11 (WT: 4.72 Х 10 -11 ) 1616 G476SG476S 4.60 Х 10-11 (WT: 4.72 Х 10-11)4.60 Х 10 -11 (WT: 4.72 Х 10 -11 ) 1717 S359NS359N 6.42 Х 10-11 (WT: 5.99 Х 10-11)6.42 Х 10 -11 (WT: 5.99 Х 10 -11 ) 1818 S477IS477I 5.63 Х 10-11 (WT: 1.02 Х 10-10)5.63 Х 10 -11 (WT: 1.02 Х 10 -10 ) 1919 V367FV367F 4.10 Х 10-11 (WT: 4.72 Х 10-11)4.10 Х 10 -11 (WT: 4.72 Х 10 -11 ) 2020 S477NS477N 4.89 Х 10-11 (WT: 3.95 Х 10-11)4.89 Х 10 -11 (WT: 3.95 Х 10 -11 ) 2121 N370SN370S 5.07 Х 10-11 (WT: 1.02 Х 10-10)5.07 Х 10 -11 (WT: 1.02 Х 10 -10 ) 2222 S477RS477R 4.78 Х 10-11 (WT: 3.95 Х 10-11)4.78 Х 10 -11 (WT: 3.95 Х 10 -11 ) 2323 A372SA372S 4.25 Х 10-11 (WT: 5.99 Х 10-11)4.25 Х 10 -11 (WT: 5.99 Х 10 -11 ) 2424 T478IT478I 4.25 Х 10-11 (WT: 3.95 Х 10-11)4.25 Х 10 -11 (WT: 3.95 Х 10 -11 ) 2525 A372TA372T 5.65 Х 10-11 (WT: 1.02 Х 10-10)5.65 Х 10 -11 (WT: 1.02 Х 10 -10 ) 2626 P479SP479S 4.11 Х 10-11 (WT: 3.95 Х 10-11)4.11 Х 10 -11 (WT: 3.95 Х 10 -11 ) 2727 F377LF377L 5.35 Х 10-11 (WT: 5.99 Х 10-11)5.35 Х 10 -11 (WT: 5.99 Х 10 -11 ) 2828 N481DN481D 5.18 Х 10-11 (WT: 7.25 Х 10-11)5.18 Х 10 -11 (WT: 7.25 Х 10 -11 ) 2929 K378RK378R 4.88 Х 10-11 (WT: 5.99 Х 10-11)4.88 Х 10 -11 (WT: 5.99 Х 10 -11 ) 3030 G482SG482S 5.69 Х 10-11 (WT: 5.10 Х 10-11)5.69 Х 10 -11 (WT: 5.10 Х 10 -11 ) 3131 K378NK378N 6.08 Х 10-11 (WT: 5.99 Х 10-11)6.08 Х 10 -11 (WT: 5.99 Х 10 -11 ) 3232 V483AV483A 4.64 Х 10-11 (WT: 4.72 Х 10-11)4.64 Х 10 -11 (WT: 4.72 Х 10 -11 ) 3333 P384LP384L 4.97 Х 10-11 (WT: 5.99 Х 10-11)4.97 Х 10 -11 (WT: 5.99 Х 10 -11 ) 3434 V483IV483I 6.17 Х 10-11 (WT: 6.75 Х 10-11)6.17 Х 10 -11 (WT: 6.75 Х 10 -11 ) 3535 T385AT385A 6.79 Х 10-11 (WT: 5.99 Х 10-11)6.79 Х 10 -11 (WT: 5.99 Х 10 -11 ) 3636 G485SG485S 7.47 Х 10-11 (WT: 6.75 Х 10-11)7.47 Х 10 -11 (WT: 6.75 Х 10 -11 ) 3737 T393PT393P 6.24 Х 10-11 (WT: 5.99 Х 10-11)6.24 Х 10 -11 (WT: 5.99 Х 10 -11 ) 3838 F486SF486S 6.58 Х 10-11 (WT: 7.25 Х 10-11)6.58 Х 10 -11 (WT: 7.25 Х 10 -11 ) 3939 V395IV395I 7.01 Х 10-11 (WT: 1.02 Х 10-10)7.01 Х 10 -11 (WT: 1.02 Х 10 -10 ) 4040 F490SF490S 6.89 Х 10-11 (WT: 5.10 Х 10-11)6.89 Х 10 -11 (WT: 5.10 Х 10 -11 ) 4141 E406QE406Q 1.24 Х 10-10 (WT: 3.95 Х 10-11)1.24 Х 10 -10 (WT: 3.95 Х 10 -11 ) 4242 S494PS494P 4.49 Х 10-8 (WT: 6.75 Х 10-11)4.49 Х 10 -8 (WT: 6.75 Х 10 -11 ) 4343 R408IR408I 5.51 Х 10-11 (WT: 3.95 Х 10-11)5.51 Х 10 -11 (WT: 3.95 Х 10 -11 ) 4444 P499RP499R 7.75 Х 10-11 (WT: 7.25 Х 10-11)7.75 Х 10 -11 (WT: 7.25 Х 10 -11 ) 4545 Q409EQ409E 6.83 Х 10-11 (WT: 1.02 Х 10-10)6.83 Х 10 -11 (WT: 1.02 Х 10 -10 ) 4646 V503FV503F 4.91 Х 10-11 (WT: 3.95 Х 10-11)4.91 Х 10 -11 (WT: 3.95 Х 10 -11 ) 4747 D405V/Q414AD405V/Q414A 5.60 Х 10-11 (WT: 5.99 Х 10-11)5.60 Х 10 -11 (WT: 5.99 Х 10 -11 ) 4848 Y505CY505C 7.16 Х 10-11 (WT: 7.66 Х 10-11)7.16 Х 10 -11 (WT: 7.66 Х 10 -11 ) 4949 Q414EQ414E 4.68 Х 10-11 (WT: 5.99 Х 10-11)4.68 Х 10 -11 (WT: 5.99 Х 10 -11 ) 5050 Y508HY508H 4.28 Х 10-11 (WT: 3.95 Х 10-11)4.28 Х 10 -11 (WT: 3.95 Х 10 -11 ) 5151 Q414RQ414R 1.14 Х 10-10 (WT: 1.02 Х 10-10)1.14 Х 10 -10 (WT: 1.02 Х 10 -10 ) 5252 A520SA520S 7.06 Х 10-11 (WT: 5.99 Х 10-11)7.06 Х 10 -11 (WT: 5.99 Х 10 -11 ) 5353 K417NK417N 5.14 Х 10-11 (WT: 5.10 Х 10-11)5.14 Х 10 -11 (WT: 5.10 Х 10 -11 ) 5454 A520VA520V 5.42 Х 10-11 (WT: 1.02 Х 10-10)5.42 Х 10 -11 (WT: 1.02 Х 10 -10 ) 5555 A435SA435S 5.52 Х 10-11 (WT: 4.72 Х 10-11)5.52 Х 10 -11 (WT: 4.72 Х 10 -11 ) 5656 P521SP521S 5.59 Х 10-11 (WT: 3.95 Х 10-11)5.59 Х 10 -11 (WT: 3.95 Х 10 -11 ) 5757 W436RW436R 3.98 Х 10-11 (WT: 4.72 Х 10-11)3.98 Х 10 -11 (WT: 4.72 Х 10 -11 ) 5858 P521RP521R 5.85 Х 10-11 (WT: 3.95 Х 10-11)5.85 Х 10 -11 (WT: 3.95 Х 10 -11 ) 5959 N439KN439K 6.93 Х 10-11 (WT: 3.95 Х 10-11)6.93 Х 10 -11 (WT: 3.95 Х 10 -11 ) 6060 A522VA522V 5.31 Х 10-11 (WT: 3.95 Х 10-11)5.31 Х 10 -11 (WT: 3.95 Х 10 -11 ) 6161 N440KN440K 5.88 Х 10-11 (WT: 3.95 Х 10-11)5.88 Х 10 -11 (WT: 3.95 Х 10 -11 ) 6262 A522SA522S 5.97 Х 10-11 (WT: 5.99 Х 10-11)5.97 Х 10 -11 (WT: 5.99 Х 10 -11 ) 6363 K444RK444R 9.29 Х 10-11 (WT: 3.95 Х 10-11)9.29 Х 10 -11 (WT: 3.95 Х 10 -11 ) 6464 K458QK458Q 6.29 Х 10-11 (WT: 6.41 Х 10-11)6.29 Х 10 -11 (WT: 6.41 Х 10 -11 ) 6565 V445FV445F 8.76 Х 10-11 (WT: 7.25 Х 10-11)8.76 Х 10 -11 (WT: 7.25 Х 10 -11 ) 6666 E484KE484K 1.10 Х 10-10 (WT: 6.41 Х 10-11)1.10 Х 10 -10 (WT: 6.41 Х 10 -11 ) 6767 G446VG446V 7.48 Х 10-11 (WT: 7.66 Х 10-11)7.48 Х 10 -11 (WT: 7.66 Х 10 -11 ) 6868 N501YN501Y 9.30 Х 10-11 (WT: 4.76 Х 10-11)9.30 Х 10 -11 (WT: 4.76 Х 10 -11 ) 6969 F456EF456E 4.47 Х 10-10 (WT: 7.25 Х 10-11)4.47 Х 10 -10 (WT: 7.25 Х 10 -11 ) 7070 K417N/E484K/N501YK417N/E484K/N501Y 9.41 Х 10-10 (WT: 9.46 Х 10-11)9.41 Х 10 -10 (WT: 9.46 Х 10 -11 ) 7171 K417T/E484K/N501YK417T/E484K/N501Y 7.69 Х 10-10 (WT: 6.32 Х 10-11)7.69 Х 10 -10 (WT: 6.32 Х 10 -11 )

<110> CELLTRION, INC. <120> SARS-CoV-2 NEUTRALIZING BINDING MOLECULE BINDING TO EPITOPES OF SARS-CoV-2 SPIKE PROTEIN <130> CPD2021050KR <150> KR 10-2020-0091979 <151> 2020-07-23 <150> KR 10-2020-0104969 <151> 2020-08-20 <150> KR 10-2020-0152212 <151> 2020-11-13 <150> KR 10-2021-0019449 <151> 2021-02-10 <150> KR 10-2021-0040750 <151> 2021-03-29 <150> KR 10-2021-0075093 <151> 2021-06-09 <160> 2321 <170> KoPatentIn 3.0 <210> 1 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 1 LC CDR1 <400> 1 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 1 LC CDR2 <400> 2 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 3 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 1 LC CDR3 <400> 3 Gln Gln Ser Tyr Ser Thr Pro Phe Thr 1 5 <210> 4 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 1 HC CDR1 <400> 4 Asp Tyr Ala Met His 1 5 <210> 5 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 1 HC CDR2 <400> 5 Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 6 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 1 HC CDR3 <400> 6 Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu Asp Ala 1 5 10 15 Phe Asp Ile <210> 7 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 2 LC CDR1 <400> 7 Arg Ala Ser Gln Ser Ile Ser Thr Tyr Leu Asn 1 5 10 <210> 8 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 2 LC CDR2 <400> 8 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 9 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 2 LC CDR3 <400> 9 Gln Gln Ser Tyr Ser Ile Pro His Thr 1 5 <210> 10 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 2 HC CDR1 <400> 10 Asp Tyr Ala Met His 1 5 <210> 11 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 2 HC CDR2 <400> 11 Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 12 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 2 HC CDR3 <400> 12 Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu Asp Ala 1 5 10 15 Phe Asp Ile <210> 13 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 3 LC CDR1 <400> 13 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 14 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 3 LC CDR2 <400> 14 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 15 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 3 LC CDR3 <400> 15 Gln Gln Tyr Asp Asn Leu Pro Ile Thr 1 5 <210> 16 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 3 HC CDR1 <400> 16 Ser Tyr Ala Met Ser 1 5 <210> 17 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 3 HC CDR2 <400> 17 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 18 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 3 HC CDR3 <400> 18 Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr Ser Trp 1 5 10 15 Phe Asp Pro <210> 19 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 4 LC CDR1 <400> 19 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 20 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 4 LC CDR2 <400> 20 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 21 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 4 LC CDR3 <400> 21 Gln Gln Tyr Asp Asp Leu Pro Ile Thr 1 5 <210> 22 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 4 HC CDR1 <400> 22 Ser Tyr Ala Met Ser 1 5 <210> 23 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 4 HC CDR2 <400> 23 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 24 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 4 HC CDR3 <400> 24 Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr Ser Trp 1 5 10 15 Phe Asp Pro <210> 25 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 5 LC CDR1 <400> 25 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 26 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 5 LC CDR2 <400> 26 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 27 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 5 LC CDR3 <400> 27 Gln Gln Tyr Asp Asn Leu Pro Ile Thr 1 5 <210> 28 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 5 HC CDR1 <400> 28 Ser Tyr Ala Met Ser 1 5 <210> 29 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 5 HC CDR2 <400> 29 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 30 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 5 HC CDR3 <400> 30 Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr Ser Trp 1 5 10 15 Phe Asp Pro <210> 31 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 6 LC CDR1 <400> 31 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 32 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 6 LC CDR2 <400> 32 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 33 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 6 LC CDR3 <400> 33 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 34 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 6 HC CDR1 <400> 34 Ser Tyr Ala Ile Ser 1 5 <210> 35 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 6 HC CDR2 <400> 35 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 36 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 6 HC CDR3 <400> 36 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 37 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 7 LC CDR1 <400> 37 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 38 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 7 LC CDR2 <400> 38 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 39 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 7 LC CDR3 <400> 39 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 40 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 7 HC CDR1 <400> 40 Ser Tyr Ala Ile Ser 1 5 <210> 41 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 7 HC CDR2 <400> 41 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 42 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 7 HC CDR3 <400> 42 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 43 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC CDR1 <400> 43 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 44 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC CDR2 <400> 44 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 45 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC CDR3 <400> 45 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 46 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC CDR1 <400> 46 Ser Tyr Ala Ile Ser 1 5 <210> 47 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC CDR2 <400> 47 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 48 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC CDR3 <400> 48 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 49 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.9 LC CDR1 <400> 49 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 50 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.9 LC CDR2 <400> 50 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 51 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.9 LC CDR3 <400> 51 Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 1 5 10 <210> 52 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.9 HC CDR1 <400> 52 Ser Tyr Ala Ile Ser 1 5 <210> 53 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.9 HC CDR2 <400> 53 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 54 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.9 HC CDR3 <400> 54 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 55 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC CDR1 <400> 55 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 56 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC CDR2 <400> 56 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 57 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC CDR3 <400> 57 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 58 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC CDR1 <400> 58 Ser Tyr Ala Ile Ser 1 5 <210> 59 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC CDR2 <400> 59 Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 60 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC CDR3 <400> 60 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 61 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.11 LC CDR1 <400> 61 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 62 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.11 LC CDR2 <400> 62 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 63 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.11 LC CDR3 <400> 63 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 64 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.11 HC CDR1 <400> 64 Ser Tyr Ala Ile Ser 1 5 <210> 65 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.11 HC CDR2 <400> 65 Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 66 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.11 HC CDR3 <400> 66 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 67 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.12 LC CDR1 <400> 67 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 68 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.12 LC CDR2 <400> 68 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 69 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.12 LC CDR3 <400> 69 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 70 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.12 HC CDR1 <400> 70 Ser Tyr Ala Ile Ser 1 5 <210> 71 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.12 HC CDR2 <400> 71 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 72 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.12 HC CDR3 <400> 72 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 73 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.13 LC CDR1 <400> 73 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Tyr 1 5 10 <210> 74 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.13 LC CDR2 <400> 74 Gly Asn Tyr Gln Arg Pro Ser 1 5 <210> 75 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.13 LC CDR3 <400> 75 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 76 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.13 HC CDR1 <400> 76 Ser Tyr Ala Ile Ser 1 5 <210> 77 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.13 HC CDR2 <400> 77 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 78 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.13 HC CDR3 <400> 78 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 79 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.14 LC CDR1 <400> 79 Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn Tyr Val His 1 5 10 <210> 80 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.14 LC CDR2 <400> 80 Ser Asn Asp Gln Arg Pro Ser 1 5 <210> 81 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.14 LC CDR3 <400> 81 Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 1 5 10 <210> 82 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.14 HC CDR1 <400> 82 Ser Tyr Ala Ile Ser 1 5 <210> 83 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.14 HC CDR2 <400> 83 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 84 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.14 HC CDR3 <400> 84 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 85 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.15 LC CDR1 <400> 85 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 86 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.15 LC CDR2 <400> 86 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 87 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.15 LC CDR3 <400> 87 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 88 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.15 HC CDR1 <400> 88 Ser Tyr Ala Ile Ser 1 5 <210> 89 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.15 HC CDR2 <400> 89 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 90 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.15 HC CDR3 <400> 90 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 91 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC CDR1 <400> 91 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 92 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC CDR2 <400> 92 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 93 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC CDR3 <400> 93 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 94 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC CDR1 <400> 94 Ser Tyr Ala Ile Ser 1 5 <210> 95 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC CDR2 <400> 95 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 96 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC CDR3 <400> 96 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 97 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC CDR1 <400> 97 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 98 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC CDR2 <400> 98 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 99 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC CDR3 <400> 99 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 100 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC CDR1 <400> 100 Ser Tyr Ala Ile Ser 1 5 <210> 101 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC CDR2 <400> 101 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 102 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC CDR3 <400> 102 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 103 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.18 LC CDR1 <400> 103 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 104 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.18 LC CDR2 <400> 104 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 105 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.18 LC CDR3 <400> 105 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Lys Val 1 5 10 <210> 106 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.18 HC CDR1 <400> 106 Ser Tyr Ala Ile Ser 1 5 <210> 107 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.18 HC CDR2 <400> 107 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 108 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.18 HC CDR3 <400> 108 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 109 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC CDR1 <400> 109 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 110 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC CDR2 <400> 110 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 111 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC CDR3 <400> 111 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 112 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.19 HC CDR1 <400> 112 Ser Tyr Ala Ile Ser 1 5 <210> 113 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.19 HC CDR2 <400> 113 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 114 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.19 HC CDR3 <400> 114 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 115 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.20 LC CDR1 <400> 115 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 116 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.20 LC CDR2 <400> 116 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 117 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.20 LC CDR3 <400> 117 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 118 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.20 HC CDR1 <400> 118 Ser Tyr Ala Ile Ser 1 5 <210> 119 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.20 HC CDR2 <400> 119 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 120 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.20 HC CDR3 <400> 120 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 121 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC CDR1 <400> 121 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 122 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC CDR2 <400> 122 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 123 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC CDR3 <400> 123 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 124 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC CDR1 <400> 124 Ser Tyr Ala Ile Ser 1 5 <210> 125 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC CDR2 <400> 125 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 126 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC CDR3 <400> 126 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 127 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.22 LC CDR1 <400> 127 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 128 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.22 LC CDR2 <400> 128 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 129 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.22 LC CDR3 <400> 129 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 130 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.22 HC CDR1 <400> 130 Ser Tyr Ala Ile Ser 1 5 <210> 131 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.22 HC CDR2 <400> 131 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 132 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.22 HC CDR3 <400> 132 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 133 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC CDR1 <400> 133 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 134 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC CDR2 <400> 134 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 135 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC CDR3 <400> 135 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 136 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.23 HC CDR1 <400> 136 Ser Tyr Ala Ile Ser 1 5 <210> 137 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.23 HC CDR2 <400> 137 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 138 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.23 HC CDR3 <400> 138 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 139 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.24 LC CDR1 <400> 139 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 140 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.24 LC CDR2 <400> 140 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 141 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.24 LC CDR3 <400> 141 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 142 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.24 HC CDR1 <400> 142 Ser Tyr Ala Ile Ser 1 5 <210> 143 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.24 HC CDR2 <400> 143 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 144 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.24 HC CDR3 <400> 144 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 145 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC CDR1 <400> 145 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 146 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC CDR2 <400> 146 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 147 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC CDR3 <400> 147 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 148 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC CDR1 <400> 148 Ser Tyr Ala Ile Ser 1 5 <210> 149 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC CDR2 <400> 149 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 150 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC CDR3 <400> 150 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 151 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC CDR1 <400> 151 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 152 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC CDR2 <400> 152 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 153 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC CDR3 <400> 153 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 154 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC CDR1 <400> 154 Ser Tyr Ala Ile Ser 1 5 <210> 155 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC CDR2 <400> 155 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 156 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC CDR3 <400> 156 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 157 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC CDR1 <400> 157 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 158 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC CDR2 <400> 158 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 159 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC CDR3 <400> 159 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 160 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC CDR1 <400> 160 Ser Tyr Ala Ile Ser 1 5 <210> 161 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC CDR2 <400> 161 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 162 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC CDR3 <400> 162 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 163 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC CDR1 <400> 163 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 164 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC CDR2 <400> 164 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 165 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC CDR3 <400> 165 Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 1 5 10 <210> 166 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC CDR1 <400> 166 Ser Tyr Ala Ile Ser 1 5 <210> 167 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC CDR2 <400> 167 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 168 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC CDR3 <400> 168 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 169 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC CDR1 <400> 169 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 170 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC CDR2 <400> 170 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 171 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC CDR3 <400> 171 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 172 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC CDR1 <400> 172 Ser Tyr Ala Ile Ser 1 5 <210> 173 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC CDR2 <400> 173 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 174 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC CDR3 <400> 174 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 175 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.30 LC CDR1 <400> 175 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 176 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.30 LC CDR2 <400> 176 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 177 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.30 LC CDR3 <400> 177 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 178 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.30 HC CDR1 <400> 178 Ser Tyr Ala Ile Ser 1 5 <210> 179 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.30 HC CDR2 <400> 179 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 180 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.30 HC CDR3 <400> 180 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 181 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.31 LC CDR1 <400> 181 Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn Tyr Val His 1 5 10 <210> 182 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.31 LC CDR2 <400> 182 Ser Asn Asp Gln Arg Pro Ser 1 5 <210> 183 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.31 LC CDR3 <400> 183 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 184 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.31 HC CDR1 <400> 184 Ser Tyr Ala Ile Ser 1 5 <210> 185 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.31 HC CDR2 <400> 185 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 186 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.31 HC CDR3 <400> 186 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 187 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC CDR1 <400> 187 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 188 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC CDR2 <400> 188 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 189 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC CDR3 <400> 189 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 190 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC CDR1 <400> 190 Ser Tyr Ala Ile Ser 1 5 <210> 191 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC CDR2 <400> 191 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 192 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC CDR3 <400> 192 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 193 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC CDR1 <400> 193 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 194 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC CDR2 <400> 194 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 195 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC CDR3 <400> 195 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 196 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC CDR1 <400> 196 Ser Tyr Ala Ile Ser 1 5 <210> 197 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC CDR2 <400> 197 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 198 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC CDR3 <400> 198 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 199 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC CDR1 <400> 199 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 200 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC CDR2 <400> 200 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 201 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC CDR3 <400> 201 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 202 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC CDR1 <400> 202 Ser Tyr Ala Ile Ser 1 5 <210> 203 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC CDR2 <400> 203 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 204 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC CDR3 <400> 204 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 205 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC CDR1 <400> 205 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 206 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC CDR2 <400> 206 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 207 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC CDR3 <400> 207 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 208 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC CDR1 <400> 208 Ser Tyr Ala Ile Ser 1 5 <210> 209 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC CDR2 <400> 209 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 210 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC CDR3 <400> 210 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 211 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC CDR1 <400> 211 Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 212 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC CDR2 <400> 212 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 213 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC CDR3 <400> 213 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 214 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC CDR1 <400> 214 Ser Tyr Ala Ile Ser 1 5 <210> 215 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC CDR2 <400> 215 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 216 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC CDR3 <400> 216 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 217 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC CDR1 <400> 217 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 218 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC CDR2 <400> 218 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 219 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC CDR3 <400> 219 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 220 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC CDR1 <400> 220 Ser Tyr Ala Ile Ser 1 5 <210> 221 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC CDR2 <400> 221 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 222 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC CDR3 <400> 222 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 223 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC CDR1 <400> 223 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 224 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC CDR2 <400> 224 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 225 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC CDR3 <400> 225 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 226 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.38 HC CDR1 <400> 226 Ser Tyr Ala Ile Ser 1 5 <210> 227 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.38 HC CDR2 <400> 227 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 228 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.38 HC CDR3 <400> 228 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 229 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC CDR1 <400> 229 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 230 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC CDR2 <400> 230 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 231 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC CDR3 <400> 231 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 232 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC CDR1 <400> 232 Ser Tyr Ala Ile Ser 1 5 <210> 233 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC CDR2 <400> 233 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 234 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC CDR3 <400> 234 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 235 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.40 LC CDR1 <400> 235 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 236 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.40 LC CDR2 <400> 236 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 237 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.40 LC CDR3 <400> 237 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 238 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.40 HC CDR1 <400> 238 Ser Tyr Ala Ile Ser 1 5 <210> 239 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.40 HC CDR2 <400> 239 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 240 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.40 HC CDR3 <400> 240 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 241 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC CDR1 <400> 241 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 242 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC CDR2 <400> 242 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 243 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC CDR3 <400> 243 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 244 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC CDR1 <400> 244 Ser Tyr Ala Ile Ser 1 5 <210> 245 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC CDR2 <400> 245 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 246 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC CDR3 <400> 246 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 247 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC CDR1 <400> 247 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 248 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC CDR2 <400> 248 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 249 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC CDR3 <400> 249 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 250 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC CDR1 <400> 250 Ser Tyr Ala Ile Ser 1 5 <210> 251 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC CDR2 <400> 251 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 252 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC CDR3 <400> 252 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 253 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC CDR1 <400> 253 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 254 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC CDR2 <400> 254 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 255 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC CDR3 <400> 255 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 256 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC CDR1 <400> 256 Ser Tyr Ala Ile Ser 1 5 <210> 257 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC CDR2 <400> 257 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 258 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC CDR3 <400> 258 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 259 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC CDR1 <400> 259 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 260 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC CDR2 <400> 260 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 261 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC CDR3 <400> 261 Gln Gln Tyr Val Thr Thr Pro Tyr Thr 1 5 <210> 262 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC CDR1 <400> 262 Arg Ser Ser Tyr Tyr Trp Gly 1 5 <210> 263 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC CDR2 <400> 263 Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 264 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC CDR3 <400> 264 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 265 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC CDR1 <400> 265 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 266 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC CDR2 <400> 266 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 267 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC CDR3 <400> 267 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 268 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC CDR1 <400> 268 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 269 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC CDR2 <400> 269 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 270 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC CDR3 <400> 270 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 271 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC CDR1 <400> 271 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 272 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC CDR2 <400> 272 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 273 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC CDR3 <400> 273 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 274 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC CDR1 <400> 274 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 275 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC CDR2 <400> 275 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 276 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC CDR3 <400> 276 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 277 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC CDR1 <400> 277 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 278 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC CDR2 <400> 278 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 279 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC CDR3 <400> 279 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 280 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC CDR1 <400> 280 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 281 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC CDR2 <400> 281 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 282 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC CDR3 <400> 282 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 283 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC CDR1 <400> 283 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 284 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC CDR2 <400> 284 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 285 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC CDR3 <400> 285 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 286 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC CDR1 <400> 286 His Tyr Phe Trp Ser 1 5 <210> 287 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC CDR2 <400> 287 Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 288 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC CDR3 <400> 288 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 289 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.49 LC CDR1 <400> 289 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 290 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.49 LC CDR2 <400> 290 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 291 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.49 LC CDR3 <400> 291 Ser Ser Tyr Thr Ser Ser Ser Thr Val Val 1 5 10 <210> 292 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.49 HC CDR1 <400> 292 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 293 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.49 HC CDR2 <400> 293 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 294 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.49 HC CDR3 <400> 294 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 295 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC CDR1 <400> 295 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 296 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC CDR2 <400> 296 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 297 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC CDR3 <400> 297 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 298 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC CDR1 <400> 298 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 299 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC CDR2 <400> 299 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 300 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC CDR3 <400> 300 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 301 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC CDR1 <400> 301 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 302 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC CDR2 <400> 302 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 303 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC CDR3 <400> 303 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 304 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC CDR1 <400> 304 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 305 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC CDR2 <400> 305 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 306 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC CDR3 <400> 306 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 307 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.52 LC CDR1 <400> 307 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 308 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.52 LC CDR2 <400> 308 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 309 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.52 LC CDR3 <400> 309 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 310 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.52 HC CDR1 <400> 310 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 311 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.52 HC CDR2 <400> 311 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 312 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.52 HC CDR3 <400> 312 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 313 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC CDR1 <400> 313 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 314 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC CDR2 <400> 314 Gly Gly Ser Ser Arg Ala Thr 1 5 <210> 315 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC CDR3 <400> 315 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 316 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC CDR1 <400> 316 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 317 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC CDR2 <400> 317 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 318 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC CDR3 <400> 318 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 319 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC CDR1 <400> 319 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 320 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC CDR2 <400> 320 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 321 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC CDR3 <400> 321 Ser Ser Tyr Thr Ser Ser Ser Thr His Val 1 5 10 <210> 322 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC CDR1 <400> 322 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 323 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC CDR2 <400> 323 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 324 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC CDR3 <400> 324 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 325 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC CDR1 <400> 325 Arg Ala Ser Gln Ser Val Ser Thr Tyr Leu Ala 1 5 10 <210> 326 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC CDR2 <400> 326 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 327 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC CDR3 <400> 327 Gln Gln Tyr Gly Ser Ser Pro Ser Ile Thr 1 5 10 <210> 328 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC CDR1 <400> 328 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 329 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC CDR2 <400> 329 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 330 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC CDR3 <400> 330 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 331 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC CDR1 <400> 331 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 332 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC CDR2 <400> 332 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 333 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC CDR3 <400> 333 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 334 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC CDR1 <400> 334 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 335 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC CDR2 <400> 335 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 336 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC CDR3 <400> 336 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 337 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.57 LC CDR1 <400> 337 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 338 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.57 LC CDR2 <400> 338 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 339 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.57 LC CDR3 <400> 339 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 340 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.57 HC CDR1 <400> 340 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 341 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.57 HC CDR2 <400> 341 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 342 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.57 HC CDR3 <400> 342 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 343 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.58 LC CDR1 <400> 343 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 344 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.58 LC CDR2 <400> 344 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 345 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.58 LC CDR3 <400> 345 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 346 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.58 HC CDR1 <400> 346 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 347 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.58 HC CDR2 <400> 347 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 348 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.58 HC CDR3 <400> 348 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 349 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC CDR1 <400> 349 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 350 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC CDR2 <400> 350 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 351 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC CDR3 <400> 351 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 352 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC CDR1 <400> 352 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 353 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC CDR2 <400> 353 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 354 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC CDR3 <400> 354 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 355 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC CDR1 <400> 355 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 356 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC CDR2 <400> 356 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 357 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC CDR3 <400> 357 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 358 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.60 HC CDR1 <400> 358 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 359 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.60 HC CDR2 <400> 359 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 360 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.60 HC CDR3 <400> 360 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 361 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC CDR1 <400> 361 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 362 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC CDR2 <400> 362 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 363 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC CDR3 <400> 363 Gln Gln Tyr Tyr Ser Thr Pro Ser Ile Thr 1 5 10 <210> 364 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC CDR1 <400> 364 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 365 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC CDR2 <400> 365 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 366 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC CDR3 <400> 366 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 367 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC CDR1 <400> 367 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 368 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC CDR2 <400> 368 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 369 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC CDR3 <400> 369 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 370 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC CDR1 <400> 370 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 371 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC CDR2 <400> 371 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 372 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC CDR3 <400> 372 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 373 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC CDR1 <400> 373 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 374 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC CDR2 <400> 374 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 375 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC CDR3 <400> 375 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 376 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC CDR1 <400> 376 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 377 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC CDR2 <400> 377 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 378 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC CDR3 <400> 378 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 379 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC CDR1 <400> 379 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 380 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC CDR2 <400> 380 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 381 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC CDR3 <400> 381 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 382 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC CDR1 <400> 382 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 383 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC CDR2 <400> 383 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 384 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC CDR3 <400> 384 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 385 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC CDR1 <400> 385 Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala 1 5 10 <210> 386 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC CDR2 <400> 386 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 387 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC CDR3 <400> 387 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 388 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC CDR1 <400> 388 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 389 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC CDR2 <400> 389 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 390 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC CDR3 <400> 390 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 391 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC CDR1 <400> 391 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 392 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC CDR2 <400> 392 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 393 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC CDR3 <400> 393 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 394 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC CDR1 <400> 394 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 395 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC CDR2 <400> 395 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 396 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC CDR3 <400> 396 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 397 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC CDR1 <400> 397 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 398 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC CDR2 <400> 398 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 399 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC CDR3 <400> 399 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 400 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC CDR1 <400> 400 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 401 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC CDR2 <400> 401 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 402 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC CDR3 <400> 402 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 403 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC CDR1 <400> 403 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 404 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC CDR2 <400> 404 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 405 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC CDR3 <400> 405 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 406 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC CDR1 <400> 406 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 407 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC CDR2 <400> 407 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 408 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC CDR3 <400> 408 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 409 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC CDR1 <400> 409 Arg Ala Ser Gln Ser Val Arg Ser Ser Tyr Leu Ala 1 5 10 <210> 410 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC CDR2 <400> 410 Ala Ala Ser Thr Arg Ala Thr 1 5 <210> 411 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC CDR3 <400> 411 Gln Gln Tyr Gly Asp Ser Leu Ser Ile Thr 1 5 10 <210> 412 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC CDR1 <400> 412 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 413 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC CDR2 <400> 413 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 414 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC CDR3 <400> 414 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 415 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.70 LC CDR1 <400> 415 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 416 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.70 LC CDR2 <400> 416 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 417 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.70 LC CDR3 <400> 417 Gln Gln Tyr Gly Ser Ser Pro Ser Ile Thr 1 5 10 <210> 418 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.70 HC CDR1 <400> 418 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 419 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.70 HC CDR2 <400> 419 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 420 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.70 HC CDR3 <400> 420 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 421 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC CDR1 <400> 421 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 422 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC CDR2 <400> 422 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 423 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC CDR3 <400> 423 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 424 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC CDR1 <400> 424 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 425 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC CDR2 <400> 425 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 426 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC CDR3 <400> 426 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 427 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC CDR1 <400> 427 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Ser 1 5 10 <210> 428 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC CDR2 <400> 428 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 429 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC CDR3 <400> 429 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Pro 1 5 10 <210> 430 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC CDR1 <400> 430 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 431 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC CDR2 <400> 431 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 432 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC CDR3 <400> 432 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 433 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC CDR1 <400> 433 Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala 1 5 10 <210> 434 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC CDR2 <400> 434 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 435 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC CDR3 <400> 435 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 436 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC CDR1 <400> 436 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 437 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC CDR2 <400> 437 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 438 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC CDR3 <400> 438 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 439 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC CDR1 <400> 439 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 440 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC CDR2 <400> 440 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 441 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC CDR3 <400> 441 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 442 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC CDR1 <400> 442 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 443 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC CDR2 <400> 443 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 444 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC CDR3 <400> 444 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 445 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC CDR1 <400> 445 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 446 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC CDR2 <400> 446 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 447 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC CDR3 <400> 447 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 448 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC CDR1 <400> 448 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 449 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC CDR2 <400> 449 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 450 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC CDR3 <400> 450 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 451 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC CDR1 <400> 451 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 452 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC CDR2 <400> 452 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 453 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC CDR3 <400> 453 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 454 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC CDR1 <400> 454 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 455 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC CDR2 <400> 455 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 456 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC CDR3 <400> 456 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 457 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC CDR1 <400> 457 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 458 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC CDR2 <400> 458 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 459 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC CDR3 <400> 459 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 460 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC CDR1 <400> 460 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 461 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC CDR2 <400> 461 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 462 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC CDR3 <400> 462 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 463 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC CDR1 <400> 463 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 464 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC CDR2 <400> 464 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 465 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC CDR3 <400> 465 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 466 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC CDR1 <400> 466 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 467 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC CDR2 <400> 467 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 468 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC CDR3 <400> 468 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 469 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC CDR1 <400> 469 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 470 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC CDR2 <400> 470 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 471 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC CDR3 <400> 471 Gln Gln Tyr Tyr Ser Thr Pro Ser Ile Thr 1 5 10 <210> 472 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC CDR1 <400> 472 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 473 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC CDR2 <400> 473 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 474 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC CDR3 <400> 474 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 475 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC CDR1 <400> 475 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 476 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC CDR2 <400> 476 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 477 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC CDR3 <400> 477 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 478 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC CDR1 <400> 478 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 479 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC CDR2 <400> 479 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 480 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC CDR3 <400> 480 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 481 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC CDR1 <400> 481 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 482 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC CDR2 <400> 482 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 483 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC CDR3 <400> 483 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 484 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC CDR1 <400> 484 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 485 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC CDR2 <400> 485 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 486 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC CDR3 <400> 486 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 487 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC CDR1 <400> 487 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 488 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC CDR2 <400> 488 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 489 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC CDR3 <400> 489 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 490 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC CDR1 <400> 490 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 491 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC CDR2 <400> 491 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 492 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC CDR3 <400> 492 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 493 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC CDR1 <400> 493 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 494 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC CDR2 <400> 494 Gly Ala Ser Thr Arg Ala Thr 1 5 <210> 495 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC CDR3 <400> 495 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 496 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC CDR1 <400> 496 Gly Ser Ser Tyr Tyr Trp Gly 1 5 <210> 497 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC CDR2 <400> 497 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 498 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC CDR3 <400> 498 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 499 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC CDR1 <400> 499 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 500 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC CDR2 <400> 500 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 501 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC CDR3 <400> 501 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 502 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC CDR1 <400> 502 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 503 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC CDR2 <400> 503 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 504 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC CDR3 <400> 504 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 505 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC CDR1 <400> 505 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 506 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC CDR2 <400> 506 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 507 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC CDR3 <400> 507 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 508 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC CDR1 <400> 508 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 509 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC CDR2 <400> 509 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 510 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC CDR3 <400> 510 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 511 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC CDR1 <400> 511 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 512 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC CDR2 <400> 512 Asp Ala Ser Ser Arg Ala Thr 1 5 <210> 513 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC CDR3 <400> 513 Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 1 5 <210> 514 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC CDR1 <400> 514 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 515 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC CDR2 <400> 515 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 516 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC CDR3 <400> 516 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 517 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC CDR1 <400> 517 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 518 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC CDR2 <400> 518 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 519 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC CDR3 <400> 519 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 520 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC CDR1 <400> 520 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 521 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC CDR2 <400> 521 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 522 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC CDR3 <400> 522 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 523 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC CDR1 <400> 523 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 524 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC CDR2 <400> 524 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 525 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC CDR3 <400> 525 Gln Gln Tyr Gly Ser Ser Pro Ser Ile Thr 1 5 10 <210> 526 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC CDR1 <400> 526 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 527 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC CDR2 <400> 527 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 528 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC CDR3 <400> 528 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 529 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC CDR1 <400> 529 Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn Tyr Val Ser 1 5 10 <210> 530 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC CDR2 <400> 530 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 531 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC CDR3 <400> 531 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 532 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC CDR1 <400> 532 Thr Ser Gly Met Gly Val Gly 1 5 <210> 533 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC CDR2 <400> 533 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 534 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC CDR3 <400> 534 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 535 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC CDR1 <400> 535 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 536 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC CDR2 <400> 536 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 537 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC CDR3 <400> 537 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 538 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC CDR1 <400> 538 Thr Ser Gly Met Gly Val Gly 1 5 <210> 539 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC CDR2 <400> 539 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 540 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC CDR3 <400> 540 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 541 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC CDR1 <400> 541 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 542 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC CDR2 <400> 542 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 543 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC CDR3 <400> 543 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 544 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC CDR1 <400> 544 Thr Ser Gly Val Gly Val Gly 1 5 <210> 545 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC CDR2 <400> 545 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 546 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC CDR3 <400> 546 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 547 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC CDR1 <400> 547 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 548 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC CDR2 <400> 548 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 549 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC CDR3 <400> 549 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 550 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC CDR1 <400> 550 Thr Ser Gly Met Gly Val Gly 1 5 <210> 551 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC CDR2 <400> 551 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 552 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC CDR3 <400> 552 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 553 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC CDR1 <400> 553 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 554 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC CDR2 <400> 554 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 555 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC CDR3 <400> 555 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Arg 1 5 10 <210> 556 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC CDR1 <400> 556 Thr Ser Gly Val Gly Val Gly 1 5 <210> 557 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC CDR2 <400> 557 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 558 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC CDR3 <400> 558 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 559 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC CDR1 <400> 559 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 560 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC CDR2 <400> 560 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 561 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC CDR3 <400> 561 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 562 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC CDR1 <400> 562 Thr Ser Gly Met Gly Val Gly 1 5 <210> 563 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC CDR2 <400> 563 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 564 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC CDR3 <400> 564 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 565 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC CDR1 <400> 565 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 566 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC CDR2 <400> 566 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 567 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC CDR3 <400> 567 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 568 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC CDR1 <400> 568 Thr Ser Gly Val Gly Val Gly 1 5 <210> 569 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC CDR2 <400> 569 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 570 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC CDR3 <400> 570 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 571 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.96 LC CDR1 <400> 571 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 572 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.96 LC CDR2 <400> 572 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 573 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.96 LC CDR3 <400> 573 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 574 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.96 HC CDR1 <400> 574 Thr Ser Gly Met Gly Val Gly 1 5 <210> 575 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.96 HC CDR2 <400> 575 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 576 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.96 HC CDR3 <400> 576 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 577 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC CDR1 <400> 577 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 578 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC CDR2 <400> 578 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 579 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC CDR3 <400> 579 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 580 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC CDR1 <400> 580 Thr Ser Gly Met Gly Val Ser 1 5 <210> 581 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC CDR2 <400> 581 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 582 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC CDR3 <400> 582 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 583 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.98 LC CDR1 <400> 583 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 584 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.98 LC CDR2 <400> 584 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 585 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.98 LC CDR3 <400> 585 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 586 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.98 HC CDR1 <400> 586 Thr Ser Gly Met Gly Val Gly 1 5 <210> 587 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.98 HC CDR2 <400> 587 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 588 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.98 HC CDR3 <400> 588 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 589 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC CDR1 <400> 589 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 590 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC CDR2 <400> 590 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 591 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC CDR3 <400> 591 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 592 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC CDR1 <400> 592 Thr Ser Gly Met Gly Val Gly 1 5 <210> 593 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC CDR2 <400> 593 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 594 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC CDR3 <400> 594 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 595 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC CDR1 <400> 595 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 596 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC CDR2 <400> 596 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 597 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC CDR3 <400> 597 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 598 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.100 HC CDR1 <400> 598 Thr Ser Gly Met Gly Val Gly 1 5 <210> 599 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.100 HC CDR2 <400> 599 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 600 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.100 HC CDR3 <400> 600 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 601 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.101 LC CDR1 <400> 601 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 602 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.101 LC CDR2 <400> 602 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 603 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.101 LC CDR3 <400> 603 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 604 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.101 HC CDR1 <400> 604 Thr Ser Gly Met Gly Val Gly 1 5 <210> 605 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.101 HC CDR2 <400> 605 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 606 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.101 HC CDR3 <400> 606 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 607 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC CDR1 <400> 607 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 608 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC CDR2 <400> 608 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 609 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC CDR3 <400> 609 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 610 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC CDR1 <400> 610 Thr Ser Gly Met Gly Val Gly 1 5 <210> 611 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC CDR2 <400> 611 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 612 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC CDR3 <400> 612 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 613 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC CDR1 <400> 613 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 614 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC CDR2 <400> 614 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 615 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC CDR3 <400> 615 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 616 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC CDR1 <400> 616 Thr Ser Gly Val Gly Val Gly 1 5 <210> 617 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC CDR2 <400> 617 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 618 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC CDR3 <400> 618 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 619 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC CDR1 <400> 619 Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 620 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC CDR2 <400> 620 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 621 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC CDR3 <400> 621 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 622 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC CDR1 <400> 622 Thr Ser Gly Val Gly Val Gly 1 5 <210> 623 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC CDR2 <400> 623 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 624 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC CDR3 <400> 624 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 625 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC CDR1 <400> 625 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 626 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC CDR2 <400> 626 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 627 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC CDR3 <400> 627 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 628 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC CDR1 <400> 628 Thr Ser Gly Val Gly Val Gly 1 5 <210> 629 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC CDR2 <400> 629 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 630 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC CDR3 <400> 630 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 631 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC CDR1 <400> 631 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 632 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC CDR2 <400> 632 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 633 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC CDR3 <400> 633 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 634 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC CDR1 <400> 634 Thr Ser Gly Met Gly Val Gly 1 5 <210> 635 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC CDR2 <400> 635 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 636 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC CDR3 <400> 636 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 637 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC CDR1 <400> 637 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 638 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC CDR2 <400> 638 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 639 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC CDR3 <400> 639 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 640 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC CDR1 <400> 640 Thr Ser Gly Met Gly Val Gly 1 5 <210> 641 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC CDR2 <400> 641 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 642 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC CDR3 <400> 642 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 643 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC CDR1 <400> 643 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 644 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC CDR2 <400> 644 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 645 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC CDR3 <400> 645 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 646 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC CDR1 <400> 646 Thr Ser Gly Met Gly Val Gly 1 5 <210> 647 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC CDR2 <400> 647 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 648 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC CDR3 <400> 648 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 649 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC CDR1 <400> 649 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 650 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC CDR2 <400> 650 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 651 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC CDR3 <400> 651 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 652 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC CDR1 <400> 652 Thr Ser Gly Met Gly Val Gly 1 5 <210> 653 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC CDR2 <400> 653 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 654 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC CDR3 <400> 654 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 655 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC CDR1 <400> 655 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 656 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC CDR2 <400> 656 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 657 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC CDR3 <400> 657 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 658 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.110 HC CDR1 <400> 658 Thr Ser Gly Met Gly Val Gly 1 5 <210> 659 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.110 HC CDR2 <400> 659 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 660 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.110 HC CDR3 <400> 660 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 661 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC CDR1 <400> 661 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 662 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC CDR2 <400> 662 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 663 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC CDR3 <400> 663 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 664 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC CDR1 <400> 664 Thr Ser Gly Met Gly Val Gly 1 5 <210> 665 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC CDR2 <400> 665 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 666 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC CDR3 <400> 666 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 667 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC CDR1 <400> 667 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 668 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC CDR2 <400> 668 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 669 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC CDR3 <400> 669 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 670 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC CDR1 <400> 670 Thr Ser Gly Val Gly Val Gly 1 5 <210> 671 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC CDR2 <400> 671 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 672 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC CDR3 <400> 672 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 673 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC CDR1 <400> 673 Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn Tyr Ile Ser 1 5 10 <210> 674 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC CDR2 <400> 674 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 675 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC CDR3 <400> 675 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 676 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC CDR1 <400> 676 Thr Ser Gly Val Gly Val Gly 1 5 <210> 677 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC CDR2 <400> 677 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 678 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC CDR3 <400> 678 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 679 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC CDR1 <400> 679 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 680 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC CDR2 <400> 680 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 681 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC CDR3 <400> 681 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 682 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC CDR1 <400> 682 Thr Ser Gly Met Gly Val Gly 1 5 <210> 683 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC CDR2 <400> 683 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 684 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC CDR3 <400> 684 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 685 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC CDR1 <400> 685 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 686 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC CDR2 <400> 686 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 687 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC CDR3 <400> 687 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 688 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC CDR1 <400> 688 Thr Ser Gly Met Gly Val Gly 1 5 <210> 689 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC CDR2 <400> 689 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 690 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC CDR3 <400> 690 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 691 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC CDR1 <400> 691 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 692 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC CDR2 <400> 692 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 693 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC CDR3 <400> 693 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 694 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC CDR1 <400> 694 Thr Ser Gly Met Gly Val Gly 1 5 <210> 695 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC CDR2 <400> 695 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 696 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC CDR3 <400> 696 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 697 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC CDR1 <400> 697 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 698 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC CDR2 <400> 698 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 699 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC CDR3 <400> 699 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 700 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC CDR1 <400> 700 Thr Ser Gly Met Gly Val Gly 1 5 <210> 701 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC CDR2 <400> 701 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 702 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC CDR3 <400> 702 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 703 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC CDR1 <400> 703 Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 704 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC CDR2 <400> 704 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 705 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC CDR3 <400> 705 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 706 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC CDR1 <400> 706 Thr Ser Gly Met Gly Val Gly 1 5 <210> 707 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC CDR2 <400> 707 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 708 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC CDR3 <400> 708 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 709 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC CDR1 <400> 709 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 710 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC CDR2 <400> 710 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 711 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC CDR3 <400> 711 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 712 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC CDR1 <400> 712 Thr Ser Gly Met Gly Val Gly 1 5 <210> 713 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC CDR2 <400> 713 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 714 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC CDR3 <400> 714 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 715 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.120 LC CDR1 <400> 715 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 716 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.120 LC CDR2 <400> 716 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 717 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.120 LC CDR3 <400> 717 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 718 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.120 HC CDR1 <400> 718 Thr Ser Gly Val Gly Val Gly 1 5 <210> 719 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.120 HC CDR2 <400> 719 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 720 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.120 HC CDR3 <400> 720 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 721 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC CDR1 <400> 721 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 722 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC CDR2 <400> 722 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 723 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC CDR3 <400> 723 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 724 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC CDR1 <400> 724 Thr Ser Gly Met Gly Val Gly 1 5 <210> 725 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC CDR2 <400> 725 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 726 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC CDR3 <400> 726 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 727 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC CDR1 <400> 727 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 728 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC CDR2 <400> 728 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 729 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC CDR3 <400> 729 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 730 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC CDR1 <400> 730 Thr Ser Gly Met Gly Val Gly 1 5 <210> 731 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC CDR2 <400> 731 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 732 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC CDR3 <400> 732 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 733 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC CDR1 <400> 733 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 734 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC CDR2 <400> 734 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 735 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC CDR3 <400> 735 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 736 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC CDR1 <400> 736 Thr Ser Gly Met Gly Val Gly 1 5 <210> 737 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC CDR2 <400> 737 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 738 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC CDR3 <400> 738 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 739 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC CDR1 <400> 739 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 740 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC CDR2 <400> 740 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 741 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC CDR3 <400> 741 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 742 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC CDR1 <400> 742 Thr Ser Gly Val Gly Val Gly 1 5 <210> 743 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC CDR2 <400> 743 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 744 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC CDR3 <400> 744 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 745 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC CDR1 <400> 745 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 746 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC CDR2 <400> 746 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 747 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC CDR3 <400> 747 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 748 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC CDR1 <400> 748 Thr Ser Gly Met Gly Val Gly 1 5 <210> 749 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC CDR2 <400> 749 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 750 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC CDR3 <400> 750 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 751 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC CDR1 <400> 751 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 752 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC CDR2 <400> 752 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 753 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC CDR3 <400> 753 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 754 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC CDR1 <400> 754 Thr Ser Gly Met Gly Val Gly 1 5 <210> 755 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC CDR2 <400> 755 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 756 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC CDR3 <400> 756 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 757 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC CDR1 <400> 757 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 758 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC CDR2 <400> 758 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 759 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC CDR3 <400> 759 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 760 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC CDR1 <400> 760 Thr Ser Gly Val Gly Val Gly 1 5 <210> 761 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC CDR2 <400> 761 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 762 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC CDR3 <400> 762 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 763 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC CDR1 <400> 763 Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Phe Val Ser 1 5 10 <210> 764 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC CDR2 <400> 764 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 765 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC CDR3 <400> 765 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 766 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.128 HC CDR1 <400> 766 Thr Ser Gly Val Gly Val Gly 1 5 <210> 767 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.128 HC CDR2 <400> 767 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 768 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.128 HC CDR3 <400> 768 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 769 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC CDR1 <400> 769 Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 770 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC CDR2 <400> 770 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 771 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC CDR3 <400> 771 Gly Thr Trp Asp Asn Asn Leu Ser Ala Gly Val 1 5 10 <210> 772 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC CDR1 <400> 772 Thr Ser Gly Val Gly Val Gly 1 5 <210> 773 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC CDR2 <400> 773 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 774 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC CDR3 <400> 774 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 775 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.130 LC CDR1 <400> 775 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 776 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.130 LC CDR2 <400> 776 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 777 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.130 LC CDR3 <400> 777 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 778 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.130 HC CDR1 <400> 778 Thr Ser Gly Met Gly Val Gly 1 5 <210> 779 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.130 HC CDR2 <400> 779 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 780 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.130 HC CDR3 <400> 780 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 781 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC CDR1 <400> 781 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 782 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC CDR2 <400> 782 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 783 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC CDR3 <400> 783 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 784 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC CDR1 <400> 784 Thr Ser Gly Val Gly Val Gly 1 5 <210> 785 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC CDR2 <400> 785 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 786 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC CDR3 <400> 786 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 787 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC CDR1 <400> 787 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 788 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC CDR2 <400> 788 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 789 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC CDR3 <400> 789 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 790 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC CDR1 <400> 790 Thr Ser Gly Met Gly Val Gly 1 5 <210> 791 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC CDR2 <400> 791 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 792 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC CDR3 <400> 792 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 793 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC CDR1 <400> 793 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 794 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC CDR2 <400> 794 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 795 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC CDR3 <400> 795 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 796 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC CDR1 <400> 796 Thr Ser Gly Met Gly Val Gly 1 5 <210> 797 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC CDR2 <400> 797 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 798 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC CDR3 <400> 798 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 799 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC CDR1 <400> 799 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 800 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC CDR2 <400> 800 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 801 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC CDR3 <400> 801 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 802 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC CDR1 <400> 802 Thr Ser Gly Met Gly Val Gly 1 5 <210> 803 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC CDR2 <400> 803 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 804 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC CDR3 <400> 804 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 805 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC CDR1 <400> 805 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 806 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC CDR2 <400> 806 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 807 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC CDR3 <400> 807 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 808 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC CDR1 <400> 808 Thr Ser Gly Met Gly Val Gly 1 5 <210> 809 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC CDR2 <400> 809 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 810 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC CDR3 <400> 810 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 811 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC CDR1 <400> 811 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 812 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC CDR2 <400> 812 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 813 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC CDR3 <400> 813 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 814 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC CDR1 <400> 814 Thr Ser Gly Met Gly Val Gly 1 5 <210> 815 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC CDR2 <400> 815 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 816 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC CDR3 <400> 816 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 817 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC CDR1 <400> 817 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 818 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC CDR2 <400> 818 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 819 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC CDR3 <400> 819 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 820 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC CDR1 <400> 820 Thr Ser Gly Val Gly Val Gly 1 5 <210> 821 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC CDR2 <400> 821 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 822 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC CDR3 <400> 822 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 823 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC CDR1 <400> 823 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 824 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC CDR2 <400> 824 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 825 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC CDR3 <400> 825 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 826 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC CDR1 <400> 826 Thr Ser Gly Val Gly Val Gly 1 5 <210> 827 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC CDR2 <400> 827 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 828 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC CDR3 <400> 828 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 829 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC CDR1 <400> 829 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 830 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC CDR2 <400> 830 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 831 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC CDR3 <400> 831 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 832 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC CDR1 <400> 832 Thr Ser Gly Val Gly Val Gly 1 5 <210> 833 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC CDR2 <400> 833 Leu Ile Asp Trp Asp Asp Asn Lys Tyr His Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 834 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC CDR3 <400> 834 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 835 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.140 LC CDR1 <400> 835 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 836 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.140 LC CDR2 <400> 836 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 837 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.140 LC CDR3 <400> 837 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 838 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.140 HC CDR1 <400> 838 Thr Ser Gly Met Gly Val Ser 1 5 <210> 839 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.140 HC CDR2 <400> 839 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 840 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.140 HC CDR3 <400> 840 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 841 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC CDR1 <400> 841 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 842 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC CDR2 <400> 842 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 843 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC CDR3 <400> 843 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 844 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC CDR1 <400> 844 Thr Ser Gly Met Gly Val Gly 1 5 <210> 845 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC CDR2 <400> 845 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 846 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC CDR3 <400> 846 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 847 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC CDR1 <400> 847 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 848 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC CDR2 <400> 848 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 849 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC CDR3 <400> 849 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 850 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC CDR1 <400> 850 Thr Ser Gly Met Gly Val Gly 1 5 <210> 851 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC CDR2 <400> 851 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 852 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC CDR3 <400> 852 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 853 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC CDR1 <400> 853 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 854 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC CDR2 <400> 854 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 855 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC CDR3 <400> 855 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 856 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC CDR1 <400> 856 Thr Ser Gly Val Gly Val Gly 1 5 <210> 857 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC CDR2 <400> 857 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 858 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC CDR3 <400> 858 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 859 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC CDR1 <400> 859 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 860 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC CDR2 <400> 860 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 861 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC CDR3 <400> 861 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 862 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC CDR1 <400> 862 Thr Ser Gly Met Gly Val Gly 1 5 <210> 863 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC CDR2 <400> 863 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 864 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC CDR3 <400> 864 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 865 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC CDR1 <400> 865 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 866 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC CDR2 <400> 866 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 867 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC CDR3 <400> 867 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 868 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC CDR1 <400> 868 Thr Ser Gly Val Gly Val Gly 1 5 <210> 869 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC CDR2 <400> 869 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 870 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC CDR3 <400> 870 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 871 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC CDR1 <400> 871 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 872 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC CDR2 <400> 872 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 873 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC CDR3 <400> 873 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 874 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC CDR1 <400> 874 Thr Ser Gly Met Gly Val Gly 1 5 <210> 875 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC CDR2 <400> 875 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 876 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC CDR3 <400> 876 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 877 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC CDR1 <400> 877 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 878 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC CDR2 <400> 878 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 879 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC CDR3 <400> 879 Gly Thr Trp Asp Ser Ser Leu Ser Gly Gly Val 1 5 10 <210> 880 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC CDR1 <400> 880 Thr Ser Gly Met Gly Val Gly 1 5 <210> 881 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC CDR2 <400> 881 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 882 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC CDR3 <400> 882 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 883 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC CDR1 <400> 883 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 884 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC CDR2 <400> 884 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 885 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC CDR3 <400> 885 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 886 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC CDR1 <400> 886 Thr Ser Gly Met Gly Val Gly 1 5 <210> 887 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC CDR2 <400> 887 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 888 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC CDR3 <400> 888 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 889 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC CDR1 <400> 889 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 890 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC CDR2 <400> 890 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 891 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC CDR3 <400> 891 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 892 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC CDR1 <400> 892 Thr Ser Gly Met Gly Val Gly 1 5 <210> 893 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC CDR2 <400> 893 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 894 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC CDR3 <400> 894 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 895 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC CDR1 <400> 895 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 896 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC CDR2 <400> 896 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 897 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC CDR3 <400> 897 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 898 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC CDR1 <400> 898 Thr Ser Gly Met Gly Val Gly 1 5 <210> 899 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC CDR2 <400> 899 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 900 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC CDR3 <400> 900 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 901 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC CDR1 <400> 901 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 902 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC CDR2 <400> 902 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 903 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC CDR3 <400> 903 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 904 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC CDR1 <400> 904 Thr Ser Gly Val Gly Val Gly 1 5 <210> 905 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC CDR2 <400> 905 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 906 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC CDR3 <400> 906 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 907 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC CDR1 <400> 907 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 908 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC CDR2 <400> 908 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 909 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC CDR3 <400> 909 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 910 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC CDR1 <400> 910 Thr Ser Gly Met Gly Val Gly 1 5 <210> 911 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC CDR2 <400> 911 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 912 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC CDR3 <400> 912 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 913 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC CDR1 <400> 913 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 914 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC CDR2 <400> 914 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 915 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC CDR3 <400> 915 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 916 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC CDR1 <400> 916 Thr Ser Gly Val Gly Val Gly 1 5 <210> 917 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC CDR2 <400> 917 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 918 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC CDR3 <400> 918 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 919 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC CDR1 <400> 919 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 920 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC CDR2 <400> 920 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 921 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC CDR3 <400> 921 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 922 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC CDR1 <400> 922 Thr Ser Gly Val Gly Val Gly 1 5 <210> 923 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC CDR2 <400> 923 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 924 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC CDR3 <400> 924 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 925 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC CDR1 <400> 925 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 926 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC CDR2 <400> 926 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 927 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC CDR3 <400> 927 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 928 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC CDR1 <400> 928 Thr Ser Gly Met Gly Val Gly 1 5 <210> 929 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC CDR2 <400> 929 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 930 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC CDR3 <400> 930 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 931 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC CDR1 <400> 931 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 932 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC CDR2 <400> 932 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 933 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC CDR3 <400> 933 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 934 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC CDR1 <400> 934 Thr Ser Gly Met Gly Val Gly 1 5 <210> 935 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC CDR2 <400> 935 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 936 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC CDR3 <400> 936 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 937 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC CDR1 <400> 937 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 938 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC CDR2 <400> 938 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 939 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC CDR3 <400> 939 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 940 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC CDR1 <400> 940 Thr Ser Gly Val Gly Val Gly 1 5 <210> 941 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC CDR2 <400> 941 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 942 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC CDR3 <400> 942 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 943 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC CDR1 <400> 943 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 944 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC CDR2 <400> 944 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 945 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC CDR3 <400> 945 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 946 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC CDR1 <400> 946 Thr Ser Gly Val Gly Val Gly 1 5 <210> 947 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC CDR2 <400> 947 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 948 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC CDR3 <400> 948 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 949 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC CDR1 <400> 949 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 950 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC CDR2 <400> 950 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 951 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC CDR3 <400> 951 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 952 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC CDR1 <400> 952 Thr Ser Gly Val Gly Val Gly 1 5 <210> 953 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC CDR2 <400> 953 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 954 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC CDR3 <400> 954 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 955 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.160 LC CDR1 <400> 955 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 956 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.160 LC CDR2 <400> 956 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 957 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.160 LC CDR3 <400> 957 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 958 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.160 HC CDR1 <400> 958 Thr Ser Gly Val Gly Val Gly 1 5 <210> 959 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.160 HC CDR2 <400> 959 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 960 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.160 HC CDR3 <400> 960 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 961 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC CDR1 <400> 961 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 962 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC CDR2 <400> 962 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 963 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC CDR3 <400> 963 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 964 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC CDR1 <400> 964 Thr Ser Gly Met Gly Val Gly 1 5 <210> 965 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC CDR2 <400> 965 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 966 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC CDR3 <400> 966 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 967 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC CDR1 <400> 967 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 968 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC CDR2 <400> 968 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 969 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC CDR3 <400> 969 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 970 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC CDR1 <400> 970 Thr Ser Gly Val Gly Val Gly 1 5 <210> 971 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC CDR2 <400> 971 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 972 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC CDR3 <400> 972 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 973 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC CDR1 <400> 973 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 974 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC CDR2 <400> 974 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 975 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC CDR3 <400> 975 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 976 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC CDR1 <400> 976 Thr Ser Gly Met Gly Val Gly 1 5 <210> 977 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC CDR2 <400> 977 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 978 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC CDR3 <400> 978 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 979 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC CDR1 <400> 979 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 980 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC CDR2 <400> 980 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 981 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC CDR3 <400> 981 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 982 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC CDR1 <400> 982 Thr Ser Gly Val Gly Val Gly 1 5 <210> 983 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC CDR2 <400> 983 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 984 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC CDR3 <400> 984 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 985 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC CDR1 <400> 985 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 986 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC CDR2 <400> 986 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 987 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC CDR3 <400> 987 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 988 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC CDR1 <400> 988 Thr Ser Gly Met Gly Val Gly 1 5 <210> 989 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC CDR2 <400> 989 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 990 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC CDR3 <400> 990 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 991 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC CDR1 <400> 991 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 992 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC CDR2 <400> 992 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 993 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC CDR3 <400> 993 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 994 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC CDR1 <400> 994 Thr Ser Gly Met Gly Val Gly 1 5 <210> 995 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC CDR2 <400> 995 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 996 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC CDR3 <400> 996 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 997 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC CDR1 <400> 997 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 998 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC CDR2 <400> 998 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 999 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC CDR3 <400> 999 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1000 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC CDR1 <400> 1000 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1001 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC CDR2 <400> 1001 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1002 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC CDR3 <400> 1002 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1003 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC CDR1 <400> 1003 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1004 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC CDR2 <400> 1004 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1005 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC CDR3 <400> 1005 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1006 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC CDR1 <400> 1006 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1007 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC CDR2 <400> 1007 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1008 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC CDR3 <400> 1008 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1009 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC CDR1 <400> 1009 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 1010 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC CDR2 <400> 1010 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1011 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC CDR3 <400> 1011 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1012 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC CDR1 <400> 1012 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1013 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC CDR2 <400> 1013 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1014 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC CDR3 <400> 1014 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1015 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC CDR1 <400> 1015 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1016 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC CDR2 <400> 1016 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1017 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC CDR3 <400> 1017 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1018 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC CDR1 <400> 1018 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1019 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC CDR2 <400> 1019 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1020 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC CDR3 <400> 1020 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1021 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC CDR1 <400> 1021 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1022 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC CDR2 <400> 1022 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1023 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC CDR3 <400> 1023 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1024 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC CDR1 <400> 1024 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1025 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC CDR2 <400> 1025 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1026 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC CDR3 <400> 1026 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1027 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.172 LC CDR1 <400> 1027 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1028 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.172 LC CDR2 <400> 1028 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1029 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.172 LC CDR3 <400> 1029 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1030 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC CDR1 <400> 1030 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1031 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC CDR2 <400> 1031 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1032 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC CDR3 <400> 1032 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1033 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC CDR1 <400> 1033 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1034 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC CDR2 <400> 1034 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1035 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC CDR3 <400> 1035 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1036 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC CDR1 <400> 1036 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1037 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC CDR2 <400> 1037 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1038 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC CDR3 <400> 1038 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1039 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC CDR1 <400> 1039 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1040 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC CDR2 <400> 1040 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1041 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC CDR3 <400> 1041 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1042 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC CDR1 <400> 1042 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1043 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC CDR2 <400> 1043 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1044 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC CDR3 <400> 1044 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1045 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC CDR1 <400> 1045 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1046 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC CDR2 <400> 1046 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1047 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC CDR3 <400> 1047 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1048 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC CDR1 <400> 1048 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1049 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC CDR2 <400> 1049 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1050 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC CDR3 <400> 1050 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1051 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC CDR1 <400> 1051 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1052 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC CDR2 <400> 1052 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1053 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC CDR3 <400> 1053 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1054 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC CDR1 <400> 1054 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1055 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC CDR2 <400> 1055 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1056 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC CDR3 <400> 1056 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1057 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC CDR1 <400> 1057 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1058 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC CDR2 <400> 1058 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1059 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC CDR3 <400> 1059 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1060 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC CDR1 <400> 1060 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1061 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC CDR2 <400> 1061 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1062 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC CDR3 <400> 1062 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1063 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC CDR1 <400> 1063 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1064 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC CDR2 <400> 1064 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1065 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC CDR3 <400> 1065 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1066 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC CDR1 <400> 1066 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1067 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC CDR2 <400> 1067 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1068 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC CDR3 <400> 1068 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1069 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC CDR1 <400> 1069 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1070 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC CDR2 <400> 1070 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1071 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC CDR3 <400> 1071 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1072 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC CDR1 <400> 1072 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1073 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC CDR2 <400> 1073 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1074 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC CDR3 <400> 1074 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1075 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC CDR1 <400> 1075 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1076 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC CDR2 <400> 1076 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1077 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC CDR3 <400> 1077 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1078 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC CDR1 <400> 1078 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1079 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC CDR2 <400> 1079 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1080 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC CDR3 <400> 1080 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1081 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC CDR1 <400> 1081 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1082 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC CDR2 <400> 1082 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1083 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC CDR3 <400> 1083 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1084 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC CDR1 <400> 1084 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1085 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC CDR2 <400> 1085 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1086 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC CDR3 <400> 1086 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1087 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC CDR1 <400> 1087 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1088 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC CDR2 <400> 1088 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1089 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC CDR3 <400> 1089 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1090 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC CDR1 <400> 1090 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1091 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC CDR2 <400> 1091 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1092 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC CDR3 <400> 1092 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1093 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC CDR1 <400> 1093 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1094 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC CDR2 <400> 1094 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1095 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC CDR3 <400> 1095 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1096 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC CDR1 <400> 1096 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1097 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC CDR2 <400> 1097 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1098 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC CDR3 <400> 1098 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1099 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC CDR1 <400> 1099 Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn Tyr Val Ser 1 5 10 <210> 1100 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC CDR2 <400> 1100 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 1101 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC CDR3 <400> 1101 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1102 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC CDR1 <400> 1102 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1103 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC CDR2 <400> 1103 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1104 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC CDR3 <400> 1104 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1105 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC CDR1 <400> 1105 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1106 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC CDR2 <400> 1106 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1107 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC CDR3 <400> 1107 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1108 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC CDR1 <400> 1108 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1109 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC CDR2 <400> 1109 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1110 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC CDR3 <400> 1110 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1111 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC CDR1 <400> 1111 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1112 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC CDR2 <400> 1112 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1113 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC CDR3 <400> 1113 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1114 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC CDR1 <400> 1114 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1115 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC CDR2 <400> 1115 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1116 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC CDR3 <400> 1116 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1117 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC CDR1 <400> 1117 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1118 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC CDR2 <400> 1118 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1119 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC CDR3 <400> 1119 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1120 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC CDR1 <400> 1120 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1121 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC CDR2 <400> 1121 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1122 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC CDR3 <400> 1122 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1123 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC CDR1 <400> 1123 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1124 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC CDR2 <400> 1124 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1125 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC CDR3 <400> 1125 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1126 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC CDR1 <400> 1126 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1127 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC CDR2 <400> 1127 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1128 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC CDR3 <400> 1128 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1129 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC CDR1 <400> 1129 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1130 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC CDR2 <400> 1130 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1131 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC CDR3 <400> 1131 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1132 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC CDR1 <400> 1132 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1133 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC CDR2 <400> 1133 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1134 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC CDR3 <400> 1134 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1135 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC CDR1 <400> 1135 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1136 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC CDR2 <400> 1136 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1137 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC CDR3 <400> 1137 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1138 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC CDR1 <400> 1138 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1139 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC CDR2 <400> 1139 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1140 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC CDR3 <400> 1140 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1141 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.191 LC CDR1 <400> 1141 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1142 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.191 LC CDR2 <400> 1142 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1143 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.191 LC CDR3 <400> 1143 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1144 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.191 HC CDR1 <400> 1144 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1145 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.191 HC CDR2 <400> 1145 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1146 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.191 HC CDR3 <400> 1146 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1147 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC CDR1 <400> 1147 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1148 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC CDR2 <400> 1148 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1149 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC CDR3 <400> 1149 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1150 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC CDR1 <400> 1150 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1151 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC CDR2 <400> 1151 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1152 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC CDR3 <400> 1152 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1153 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC CDR1 <400> 1153 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1154 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC CDR2 <400> 1154 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1155 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC CDR3 <400> 1155 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1156 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC CDR1 <400> 1156 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1157 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC CDR2 <400> 1157 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1158 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC CDR3 <400> 1158 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1159 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC CDR1 <400> 1159 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1160 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC CDR2 <400> 1160 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1161 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC CDR3 <400> 1161 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1162 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC CDR1 <400> 1162 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1163 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC CDR2 <400> 1163 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1164 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC CDR3 <400> 1164 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1165 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC CDR1 <400> 1165 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 1166 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC CDR2 <400> 1166 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 1167 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC CDR3 <400> 1167 Gln Ser Tyr Asp Ser Ser Asp Trp Val 1 5 <210> 1168 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC CDR1 <400> 1168 Arg Tyr Gly Ile Ser 1 5 <210> 1169 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC CDR2 <400> 1169 Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu Gln 1 5 10 15 Gly <210> 1170 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC CDR3 <400> 1170 Val Leu Gly Ile Ala Val Ala Gly Thr Pro Ile 1 5 10 <210> 1171 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC CDR1 <400> 1171 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1172 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC CDR2 <400> 1172 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1173 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC CDR3 <400> 1173 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1174 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC CDR1 <400> 1174 Ser Tyr Ala Ile Ser 1 5 <210> 1175 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC CDR2 <400> 1175 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1176 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC CDR3 <400> 1176 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1177 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC CDR1 <400> 1177 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1178 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC CDR2 <400> 1178 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1179 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC CDR3 <400> 1179 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Ile 1 5 10 <210> 1180 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC CDR1 <400> 1180 Ser Tyr Ala Ile Ser 1 5 <210> 1181 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC CDR2 <400> 1181 Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1182 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC CDR3 <400> 1182 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1183 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC CDR1 <400> 1183 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1184 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC CDR2 <400> 1184 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1185 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC CDR3 <400> 1185 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1186 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC CDR1 <400> 1186 Ser Tyr Ala Ile Ser 1 5 <210> 1187 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC CDR2 <400> 1187 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1188 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC CDR3 <400> 1188 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1189 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC CDR1 <400> 1189 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1190 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC CDR2 <400> 1190 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1191 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC CDR3 <400> 1191 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Ile 1 5 10 <210> 1192 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC CDR1 <400> 1192 Ser Tyr Ala Ile Ser 1 5 <210> 1193 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC CDR2 <400> 1193 Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1194 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC CDR3 <400> 1194 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1195 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC CDR1 <400> 1195 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1196 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC CDR2 <400> 1196 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1197 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC CDR3 <400> 1197 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1198 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC CDR1 <400> 1198 Ser Tyr Ala Ile Ser 1 5 <210> 1199 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC CDR2 <400> 1199 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1200 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC CDR3 <400> 1200 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1201 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC CDR1 <400> 1201 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1202 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC CDR2 <400> 1202 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1203 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC CDR3 <400> 1203 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1204 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC CDR1 <400> 1204 Ser Tyr Ala Ile Ser 1 5 <210> 1205 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC CDR2 <400> 1205 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1206 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC CDR3 <400> 1206 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp Tyr 1 5 10 15 <210> 1207 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC CDR1 <400> 1207 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1208 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC CDR2 <400> 1208 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1209 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC CDR3 <400> 1209 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1210 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC CDR1 <400> 1210 Ser Tyr Ala Ile Ser 1 5 <210> 1211 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC CDR2 <400> 1211 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1212 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC CDR3 <400> 1212 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp Tyr 1 5 10 15 <210> 1213 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC CDR1 <400> 1213 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1214 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC CDR2 <400> 1214 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1215 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC CDR3 <400> 1215 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1216 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC CDR1 <400> 1216 Arg Phe Ala Met His 1 5 <210> 1217 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC CDR2 <400> 1217 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1218 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC CDR3 <400> 1218 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1219 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC CDR1 <400> 1219 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Thr Val Asn 1 5 10 <210> 1220 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC CDR2 <400> 1220 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1221 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC CDR3 <400> 1221 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1222 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC CDR1 <400> 1222 Arg Phe Ala Met His 1 5 <210> 1223 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC CDR2 <400> 1223 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1224 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC CDR3 <400> 1224 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1225 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC CDR1 <400> 1225 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1226 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC CDR2 <400> 1226 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1227 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC CDR3 <400> 1227 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1228 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC CDR1 <400> 1228 Ser Phe Ala Met His 1 5 <210> 1229 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC CDR2 <400> 1229 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1230 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC CDR3 <400> 1230 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1231 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC CDR1 <400> 1231 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1232 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC CDR2 <400> 1232 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1233 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC CDR3 <400> 1233 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1234 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC CDR1 <400> 1234 Asn Phe Ala Met His 1 5 <210> 1235 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC CDR2 <400> 1235 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1236 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC CDR3 <400> 1236 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1237 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC CDR1 <400> 1237 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1238 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC CDR2 <400> 1238 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1239 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC CDR3 <400> 1239 Ala Thr Trp Asp Asp Ala Leu Ser Gly Trp Val 1 5 10 <210> 1240 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC CDR1 <400> 1240 Arg Phe Ala Met His 1 5 <210> 1241 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC CDR2 <400> 1241 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1242 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC CDR3 <400> 1242 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1243 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC CDR1 <400> 1243 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1244 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC CDR2 <400> 1244 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1245 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC CDR3 <400> 1245 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1246 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC CDR1 <400> 1246 Arg Phe Ala Met His 1 5 <210> 1247 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC CDR2 <400> 1247 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1248 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC CDR3 <400> 1248 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1249 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC CDR1 <400> 1249 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Ala Val Asn 1 5 10 <210> 1250 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC CDR2 <400> 1250 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1251 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC CDR3 <400> 1251 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1252 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC CDR1 <400> 1252 Ser Phe Ala Met His 1 5 <210> 1253 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC CDR2 <400> 1253 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1254 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC CDR3 <400> 1254 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1255 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC CDR1 <400> 1255 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1256 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC CDR2 <400> 1256 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1257 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC CDR3 <400> 1257 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1258 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC CDR1 <400> 1258 Arg Phe Ala Met His 1 5 <210> 1259 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC CDR2 <400> 1259 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1260 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC CDR3 <400> 1260 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1261 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC CDR1 <400> 1261 Ser Gly Ser Arg Ser Asn Ile Gly Gly Asn Thr Val Asn 1 5 10 <210> 1262 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC CDR2 <400> 1262 Gly Asp Asn Gln Arg Pro Ser 1 5 <210> 1263 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC CDR3 <400> 1263 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1264 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC CDR1 <400> 1264 Thr Tyr Ser Met His 1 5 <210> 1265 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC CDR2 <400> 1265 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1266 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC CDR3 <400> 1266 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1267 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC CDR1 <400> 1267 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1268 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC CDR2 <400> 1268 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1269 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC CDR3 <400> 1269 Ala Ala Trp Glu Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1270 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC CDR1 <400> 1270 Asn Phe Ala Met His 1 5 <210> 1271 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC CDR2 <400> 1271 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1272 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC CDR3 <400> 1272 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1273 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC CDR1 <400> 1273 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1274 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC CDR2 <400> 1274 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1275 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC CDR3 <400> 1275 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1276 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC CDR1 <400> 1276 Arg Phe Ala Met His 1 5 <210> 1277 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC CDR2 <400> 1277 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1278 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC CDR3 <400> 1278 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1279 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC CDR1 <400> 1279 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1280 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC CDR2 <400> 1280 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1281 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC CDR3 <400> 1281 Ala Thr Trp Asp Asp Thr Leu Asp Ser Trp Val 1 5 10 <210> 1282 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC CDR1 <400> 1282 Asn Phe Ala Met His 1 5 <210> 1283 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC CDR2 <400> 1283 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1284 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC CDR3 <400> 1284 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1285 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC CDR1 <400> 1285 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1286 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC CDR2 <400> 1286 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1287 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC CDR3 <400> 1287 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1288 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC CDR1 <400> 1288 Ser Phe Ala Met His 1 5 <210> 1289 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC CDR2 <400> 1289 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1290 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC CDR3 <400> 1290 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1291 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC CDR1 <400> 1291 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1292 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC CDR2 <400> 1292 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1293 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC CDR3 <400> 1293 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1294 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC CDR1 <400> 1294 Ser Phe Ala Met His 1 5 <210> 1295 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC CDR2 <400> 1295 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1296 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC CDR3 <400> 1296 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1297 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC CDR1 <400> 1297 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1298 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC CDR2 <400> 1298 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1299 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC CDR3 <400> 1299 Ala Ala Trp Asp Asp Ser Leu Asn Val Trp Val 1 5 10 <210> 1300 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC CDR1 <400> 1300 Arg Phe Ala Met His 1 5 <210> 1301 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC CDR2 <400> 1301 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1302 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC CDR3 <400> 1302 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1303 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC CDR1 <400> 1303 Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn Pro Val Asn 1 5 10 <210> 1304 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC CDR2 <400> 1304 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1305 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC CDR3 <400> 1305 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1306 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC CDR1 <400> 1306 Ser Phe Ala Met His 1 5 <210> 1307 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC CDR2 <400> 1307 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1308 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC CDR3 <400> 1308 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1309 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC CDR1 <400> 1309 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1310 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC CDR2 <400> 1310 Ser Asn Ser Gln Arg Pro Ser 1 5 <210> 1311 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC CDR3 <400> 1311 Ala Gly Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1312 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC CDR1 <400> 1312 Arg Phe Ala Met His 1 5 <210> 1313 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC CDR2 <400> 1313 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1314 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC CDR3 <400> 1314 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1315 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC CDR1 <400> 1315 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1316 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC CDR2 <400> 1316 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1317 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC CDR3 <400> 1317 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1318 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.220 HC CDR1 <400> 1318 Asn Phe Ala Met His 1 5 <210> 1319 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.220 HC CDR2 <400> 1319 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1320 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.220 HC CDR3 <400> 1320 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1321 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC CDR1 <400> 1321 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1322 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC CDR2 <400> 1322 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1323 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC CDR3 <400> 1323 Ala Thr Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1324 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC CDR1 <400> 1324 Arg Phe Ala Met His 1 5 <210> 1325 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC CDR2 <400> 1325 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1326 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC CDR3 <400> 1326 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1327 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC CDR1 <400> 1327 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1328 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC CDR2 <400> 1328 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1329 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC CDR3 <400> 1329 Ala Thr Trp Asp Asp Ala Leu Ser Gly Trp Val 1 5 10 <210> 1330 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC CDR1 <400> 1330 Arg Phe Ala Met His 1 5 <210> 1331 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC CDR2 <400> 1331 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1332 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC CDR3 <400> 1332 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1333 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC CDR1 <400> 1333 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1334 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC CDR2 <400> 1334 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1335 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC CDR3 <400> 1335 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1336 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC CDR1 <400> 1336 Arg Phe Ala Met His 1 5 <210> 1337 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC CDR2 <400> 1337 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1338 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC CDR3 <400> 1338 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1339 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC CDR1 <400> 1339 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1340 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC CDR2 <400> 1340 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1341 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC CDR3 <400> 1341 Ala Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 1342 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC CDR1 <400> 1342 Ser Tyr Ser Met His 1 5 <210> 1343 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC CDR2 <400> 1343 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1344 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC CDR3 <400> 1344 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1345 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC CDR1 <400> 1345 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1346 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC CDR2 <400> 1346 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1347 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC CDR3 <400> 1347 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1348 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC CDR1 <400> 1348 Thr Tyr Ser Met His 1 5 <210> 1349 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC CDR2 <400> 1349 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1350 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC CDR3 <400> 1350 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1351 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC CDR1 <400> 1351 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1352 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC CDR2 <400> 1352 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1353 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC CDR3 <400> 1353 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1354 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC CDR1 <400> 1354 Asn Phe Ala Met His 1 5 <210> 1355 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC CDR2 <400> 1355 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1356 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC CDR3 <400> 1356 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1357 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC CDR1 <400> 1357 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1358 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC CDR2 <400> 1358 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1359 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC CDR3 <400> 1359 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1360 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC CDR1 <400> 1360 Asn Phe Ala Met His 1 5 <210> 1361 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC CDR2 <400> 1361 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1362 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC CDR3 <400> 1362 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1363 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC CDR1 <400> 1363 Ser Gly Ser Ser Ser Asn Val Gly Ser Asn Thr Val Asn 1 5 10 <210> 1364 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC CDR2 <400> 1364 Ser Asn Asp Gln Arg Pro Ser 1 5 <210> 1365 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC CDR3 <400> 1365 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1366 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC CDR1 <400> 1366 Ser Phe Ala Met His 1 5 <210> 1367 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC CDR2 <400> 1367 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1368 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC CDR3 <400> 1368 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1369 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC CDR1 <400> 1369 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1370 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC CDR2 <400> 1370 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1371 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC CDR3 <400> 1371 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1372 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC CDR1 <400> 1372 Arg Phe Ala Met His 1 5 <210> 1373 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC CDR2 <400> 1373 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1374 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC CDR3 <400> 1374 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1375 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC CDR1 <400> 1375 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1376 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC CDR2 <400> 1376 Ser Ser Asn Gln Arg Pro Ser 1 5 <210> 1377 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC CDR3 <400> 1377 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1378 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC CDR1 <400> 1378 Asn Phe Ala Met His 1 5 <210> 1379 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC CDR2 <400> 1379 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1380 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC CDR3 <400> 1380 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1381 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC CDR1 <400> 1381 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1382 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC CDR2 <400> 1382 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1383 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC CDR3 <400> 1383 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1384 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC CDR1 <400> 1384 Ser Phe Ala Met His 1 5 <210> 1385 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC CDR2 <400> 1385 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1386 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC CDR3 <400> 1386 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1387 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC CDR1 <400> 1387 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1388 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC CDR2 <400> 1388 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1389 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC CDR3 <400> 1389 Ala Ala Trp Asp Asp Ser Leu Asn Ala Trp Val 1 5 10 <210> 1390 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC CDR1 <400> 1390 Ser Tyr Ser Met His 1 5 <210> 1391 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC CDR2 <400> 1391 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1392 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC CDR3 <400> 1392 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1393 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.233 LC CDR1 <400> 1393 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1394 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.233 LC CDR2 <400> 1394 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1395 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.233 LC CDR3 <400> 1395 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1396 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.233 HC CDR1 <400> 1396 Arg Phe Ala Met His 1 5 <210> 1397 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.233 HC CDR2 <400> 1397 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1398 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.233 HC CDR3 <400> 1398 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1399 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC CDR1 <400> 1399 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1400 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC CDR2 <400> 1400 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1401 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC CDR3 <400> 1401 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1402 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC CDR1 <400> 1402 Arg Phe Ala Met His 1 5 <210> 1403 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC CDR2 <400> 1403 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1404 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC CDR3 <400> 1404 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1405 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC CDR1 <400> 1405 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1406 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC CDR2 <400> 1406 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1407 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC CDR3 <400> 1407 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1408 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC CDR1 <400> 1408 Ser Tyr Ala Met His 1 5 <210> 1409 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC CDR2 <400> 1409 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1410 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC CDR3 <400> 1410 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1411 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC CDR1 <400> 1411 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1412 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC CDR2 <400> 1412 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1413 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC CDR3 <400> 1413 Gly Thr Trp Asp Ser Asn Ser Glu Thr Trp Val 1 5 10 <210> 1414 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC CDR1 <400> 1414 Thr Tyr Ser Met His 1 5 <210> 1415 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC CDR2 <400> 1415 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1416 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC CDR3 <400> 1416 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1417 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC CDR1 <400> 1417 Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1418 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC CDR2 <400> 1418 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1419 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC CDR3 <400> 1419 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1420 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC CDR1 <400> 1420 Ser Phe Ala Met His 1 5 <210> 1421 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC CDR2 <400> 1421 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1422 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC CDR3 <400> 1422 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1423 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC CDR1 <400> 1423 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1424 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC CDR2 <400> 1424 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1425 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC CDR3 <400> 1425 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1426 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC CDR1 <400> 1426 Thr Tyr Ser Met His 1 5 <210> 1427 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC CDR2 <400> 1427 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1428 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC CDR3 <400> 1428 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1429 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC CDR1 <400> 1429 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Thr Val Asn 1 5 10 <210> 1430 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC CDR2 <400> 1430 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1431 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC CDR3 <400> 1431 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1432 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC CDR1 <400> 1432 Asn Phe Ala Met His 1 5 <210> 1433 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC CDR2 <400> 1433 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1434 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC CDR3 <400> 1434 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1435 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC CDR1 <400> 1435 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1436 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC CDR2 <400> 1436 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1437 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC CDR3 <400> 1437 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1438 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC CDR1 <400> 1438 Asn Phe Ala Met His 1 5 <210> 1439 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC CDR2 <400> 1439 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1440 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC CDR3 <400> 1440 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1441 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.241 LC CDR1 <400> 1441 Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn Ser Val Asn 1 5 10 <210> 1442 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.241 LC CDR2 <400> 1442 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1443 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.241 LC CDR3 <400> 1443 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1444 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.241 HC CDR1 <400> 1444 Ser Phe Ala Met His 1 5 <210> 1445 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.241 HC CDR2 <400> 1445 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1446 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.241 HC CDR3 <400> 1446 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1447 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.242 LC CDR1 <400> 1447 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Thr Val Asn 1 5 10 <210> 1448 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.242 LC CDR2 <400> 1448 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1449 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.242 LC CDR3 <400> 1449 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1450 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.242 HC CDR1 <400> 1450 Ser Phe Ala Met His 1 5 <210> 1451 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.242 HC CDR2 <400> 1451 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Glu Ser Val Lys 1 5 10 15 Gly <210> 1452 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.242 HC CDR3 <400> 1452 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1453 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.243 LC CDR1 <400> 1453 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1454 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.243 LC CDR2 <400> 1454 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1455 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.243 LC CDR3 <400> 1455 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1456 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.243 HC CDR1 <400> 1456 Ser Phe Ala Met His 1 5 <210> 1457 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.243 HC CDR2 <400> 1457 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1458 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.243 HC CDR3 <400> 1458 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1459 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC CDR1 <400> 1459 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1460 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC CDR2 <400> 1460 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1461 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC CDR3 <400> 1461 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1462 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC CDR1 <400> 1462 Asn Phe Ala Met His 1 5 <210> 1463 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC CDR2 <400> 1463 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1464 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC CDR3 <400> 1464 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1465 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC CDR1 <400> 1465 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1466 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC CDR2 <400> 1466 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1467 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC CDR3 <400> 1467 Ala Thr Trp Asp Asp Ser Leu Asn Ala Trp Val 1 5 10 <210> 1468 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC CDR1 <400> 1468 Arg Phe Ala Met His 1 5 <210> 1469 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC CDR2 <400> 1469 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1470 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC CDR3 <400> 1470 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1471 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC CDR1 <400> 1471 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1472 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC CDR2 <400> 1472 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1473 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC CDR3 <400> 1473 Ala Thr Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1474 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC CDR1 <400> 1474 Arg Phe Ala Met His 1 5 <210> 1475 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC CDR2 <400> 1475 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1476 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC CDR3 <400> 1476 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1477 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC CDR1 <400> 1477 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1478 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC CDR2 <400> 1478 Ser Asn Gln Arg Pro Ser 1 5 <210> 1479 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC CDR3 <400> 1479 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1480 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC CDR1 <400> 1480 Arg Phe Ala Met His 1 5 <210> 1481 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC CDR2 <400> 1481 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1482 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC CDR3 <400> 1482 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1483 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC CDR1 <400> 1483 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1484 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC CDR2 <400> 1484 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1485 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC CDR3 <400> 1485 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1486 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC CDR1 <400> 1486 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1487 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC CDR2 <400> 1487 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1488 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC CDR3 <400> 1488 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1489 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC CDR1 <400> 1489 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 1490 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC CDR2 <400> 1490 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 1491 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC CDR3 <400> 1491 Gln Val Trp Asp Gly Ser Ser Asp His Tyr Val 1 5 10 <210> 1492 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC CDR1 <400> 1492 Ser Tyr Ala Met Ser 1 5 <210> 1493 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC CDR2 <400> 1493 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1494 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC CDR3 <400> 1494 Leu Ser His Gly Val Val Gly Ala Gln Asp Ala Phe Asp Ile 1 5 10 <210> 1495 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC CDR1 <400> 1495 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1496 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC CDR2 <400> 1496 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1497 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC CDR3 <400> 1497 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1498 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC CDR1 <400> 1498 Ser Tyr Ala Ile Ser 1 5 <210> 1499 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC CDR2 <400> 1499 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1500 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC CDR3 <400> 1500 Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 1 5 10 <210> 1501 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC CDR1 <400> 1501 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1502 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC CDR2 <400> 1502 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1503 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC CDR3 <400> 1503 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1504 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC CDR1 <400> 1504 Asp Tyr Ala Met His 1 5 <210> 1505 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC CDR2 <400> 1505 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1506 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC CDR3 <400> 1506 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1507 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC CDR1 <400> 1507 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1508 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC CDR2 <400> 1508 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1509 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC CDR3 <400> 1509 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 1510 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC CDR1 <400> 1510 Asp Tyr Ala Met His 1 5 <210> 1511 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC CDR2 <400> 1511 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1512 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC CDR3 <400> 1512 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1513 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC CDR1 <400> 1513 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1514 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC CDR2 <400> 1514 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1515 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC CDR3 <400> 1515 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1516 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC CDR1 <400> 1516 Asp Tyr Ala Met His 1 5 <210> 1517 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC CDR2 <400> 1517 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1518 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC CDR3 <400> 1518 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1519 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC CDR1 <400> 1519 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 1520 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC CDR2 <400> 1520 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 1521 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC CDR3 <400> 1521 Gln Val Trp Asp Ser Ser Ser Asp His Pro Val 1 5 10 <210> 1522 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC CDR1 <400> 1522 Asp Tyr Ala Met His 1 5 <210> 1523 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC CDR2 <400> 1523 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1524 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC CDR3 <400> 1524 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1525 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC CDR1 <400> 1525 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 1526 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC CDR2 <400> 1526 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 1527 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC CDR3 <400> 1527 Gln Ser Tyr Asp Ser Ser Asn His Ala Val 1 5 10 <210> 1528 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC CDR1 <400> 1528 Asp Tyr Ala Met His 1 5 <210> 1529 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC CDR2 <400> 1529 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1530 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC CDR3 <400> 1530 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1531 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC CDR1 <400> 1531 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1532 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC CDR2 <400> 1532 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1533 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC CDR3 <400> 1533 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1534 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC CDR1 <400> 1534 Asp Tyr Ala Met His 1 5 <210> 1535 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC CDR2 <400> 1535 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1536 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC CDR3 <400> 1536 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1537 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC CDR1 <400> 1537 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1538 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC CDR2 <400> 1538 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1539 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC CDR3 <400> 1539 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1540 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC CDR1 <400> 1540 Asp Tyr Ala Met His 1 5 <210> 1541 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC CDR2 <400> 1541 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1542 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC CDR3 <400> 1542 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1543 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC CDR1 <400> 1543 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1544 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC CDR2 <400> 1544 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1545 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC CDR3 <400> 1545 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1546 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC CDR1 <400> 1546 Asp Tyr Ala Met His 1 5 <210> 1547 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC CDR2 <400> 1547 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1548 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC CDR3 <400> 1548 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1549 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC CDR1 <400> 1549 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1550 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC CDR2 <400> 1550 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1551 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC CDR3 <400> 1551 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1552 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC CDR1 <400> 1552 Asp Tyr Ala Met His 1 5 <210> 1553 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC CDR2 <400> 1553 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1554 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC CDR3 <400> 1554 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1555 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC CDR1 <400> 1555 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1556 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC CDR2 <400> 1556 Thr Asn Asn Gln Arg Pro Ser 1 5 <210> 1557 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC CDR3 <400> 1557 Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val 1 5 10 <210> 1558 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC CDR1 <400> 1558 Asp Tyr Ala Met His 1 5 <210> 1559 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC CDR2 <400> 1559 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1560 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC CDR3 <400> 1560 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1561 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC CDR1 <400> 1561 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1562 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC CDR2 <400> 1562 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 1563 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC CDR3 <400> 1563 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val 1 5 10 <210> 1564 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.261 HC CDR1 <400> 1564 Asp Tyr Ala Met His 1 5 <210> 1565 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.261 HC CDR2 <400> 1565 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1566 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.261 HC CDR3 <400> 1566 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1567 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC CDR1 <400> 1567 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1568 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC CDR2 <400> 1568 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1569 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC CDR3 <400> 1569 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Tyr Val 1 5 10 <210> 1570 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC CDR1 <400> 1570 Asp Tyr Ala Met His 1 5 <210> 1571 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC CDR2 <400> 1571 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1572 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC CDR3 <400> 1572 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1573 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC CDR1 <400> 1573 Ser Gly Ser Ser Pro Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1574 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC CDR2 <400> 1574 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1575 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC CDR3 <400> 1575 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val 1 5 10 <210> 1576 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC CDR1 <400> 1576 Asp Tyr Ala Met His 1 5 <210> 1577 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC CDR2 <400> 1577 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1578 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC CDR3 <400> 1578 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1579 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC CDR1 <400> 1579 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1580 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC CDR2 <400> 1580 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1581 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC CDR3 <400> 1581 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val 1 5 10 <210> 1582 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC CDR1 <400> 1582 Asp Tyr Ala Met His 1 5 <210> 1583 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC CDR2 <400> 1583 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1584 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC CDR3 <400> 1584 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1585 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC CDR1 <400> 1585 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1586 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC CDR2 <400> 1586 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1587 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC CDR3 <400> 1587 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val 1 5 10 <210> 1588 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC CDR1 <400> 1588 Ser Asn Tyr Met Thr 1 5 <210> 1589 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC CDR2 <400> 1589 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1590 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC CDR3 <400> 1590 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1591 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC CDR1 <400> 1591 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 1592 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC CDR2 <400> 1592 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 1593 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC CDR3 <400> 1593 Gln Val Arg Asp Ser Ser Ser Asp His Pro Val 1 5 10 <210> 1594 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC CDR1 <400> 1594 Ser Asn Tyr Met Thr 1 5 <210> 1595 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC CDR2 <400> 1595 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1596 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC CDR3 <400> 1596 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1597 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC CDR1 <400> 1597 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1598 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC CDR2 <400> 1598 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1599 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC CDR3 <400> 1599 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val 1 5 10 <210> 1600 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC CDR1 <400> 1600 Ser Asn Tyr Met Thr 1 5 <210> 1601 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC CDR2 <400> 1601 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1602 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC CDR3 <400> 1602 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1603 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC CDR1 <400> 1603 Thr Gly Ser Asp Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1604 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC CDR2 <400> 1604 Asn Asn Asn Asn Arg Pro Ser 1 5 <210> 1605 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC CDR3 <400> 1605 Gln Ser Ser Asp Ser Gly Leu Thr Gly Trp Val 1 5 10 <210> 1606 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC CDR1 <400> 1606 Ser Asn Tyr Met Thr 1 5 <210> 1607 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC CDR2 <400> 1607 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1608 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC CDR3 <400> 1608 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1609 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC CDR1 <400> 1609 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1610 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC CDR2 <400> 1610 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1611 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC CDR3 <400> 1611 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1612 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC CDR1 <400> 1612 Ser Asn Tyr Met Thr 1 5 <210> 1613 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC CDR2 <400> 1613 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1614 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC CDR3 <400> 1614 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1615 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC CDR1 <400> 1615 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 1616 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC CDR2 <400> 1616 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 1617 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC CDR3 <400> 1617 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 1618 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC CDR1 <400> 1618 Ser Asn Tyr Met Thr 1 5 <210> 1619 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC CDR2 <400> 1619 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1620 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC CDR3 <400> 1620 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1621 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC CDR1 <400> 1621 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1622 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC CDR2 <400> 1622 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1623 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC CDR3 <400> 1623 Ser Ser Tyr Ala Gly Ser Asn Asn Leu Val 1 5 10 <210> 1624 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC CDR1 <400> 1624 Ser Asn Tyr Met Thr 1 5 <210> 1625 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC CDR2 <400> 1625 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1626 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC CDR3 <400> 1626 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1627 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC CDR1 <400> 1627 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1628 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC CDR2 <400> 1628 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1629 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC CDR3 <400> 1629 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1630 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC CDR1 <400> 1630 Ser Asn Tyr Met Thr 1 5 <210> 1631 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC CDR2 <400> 1631 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1632 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC CDR3 <400> 1632 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1633 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC CDR1 <400> 1633 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 1634 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC CDR2 <400> 1634 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 1635 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC CDR3 <400> 1635 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 1636 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC CDR1 <400> 1636 Ser Asn Tyr Met Thr 1 5 <210> 1637 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC CDR2 <400> 1637 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1638 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC CDR3 <400> 1638 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1639 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC CDR1 <400> 1639 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1640 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC CDR2 <400> 1640 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1641 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC CDR3 <400> 1641 Gln Ser Tyr Asp Ser Ser Leu Gly Val Val 1 5 10 <210> 1642 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC CDR1 <400> 1642 Ser Asn Tyr Met Thr 1 5 <210> 1643 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC CDR2 <400> 1643 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1644 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC CDR3 <400> 1644 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1645 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC CDR1 <400> 1645 Gly Gly Asn Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1646 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC CDR2 <400> 1646 Ser Asn Asn Leu Arg Pro Ser 1 5 <210> 1647 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC CDR3 <400> 1647 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 1648 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC CDR1 <400> 1648 Ser Asn Tyr Met Thr 1 5 <210> 1649 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC CDR2 <400> 1649 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1650 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC CDR3 <400> 1650 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1651 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC CDR1 <400> 1651 Ser Gly Ser Ser Ser Asn Ile Gly Gly Ser Asp Val Gly 1 5 10 <210> 1652 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC CDR2 <400> 1652 Lys Ser Asn Gln Arg Pro Ser 1 5 <210> 1653 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC CDR3 <400> 1653 Ala Thr Trp Asp Asp Arg Leu Asn Trp Val 1 5 10 <210> 1654 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC CDR1 <400> 1654 Ser Asn Tyr Met Thr 1 5 <210> 1655 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC CDR2 <400> 1655 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1656 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC CDR3 <400> 1656 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1657 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC CDR1 <400> 1657 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 1658 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC CDR2 <400> 1658 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 1659 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC CDR3 <400> 1659 Gln Gln Ser Tyr Ser Thr Pro Phe Thr 1 5 <210> 1660 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC CDR1 <400> 1660 Asn Tyr Tyr Met His 1 5 <210> 1661 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC CDR2 <400> 1661 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1662 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC CDR3 <400> 1662 Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr 1 5 10 <210> 1663 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC CDR1 <400> 1663 Gln Ala Gly Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 1664 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC CDR2 <400> 1664 Lys Ala Ser Ser Leu Glu Ser 1 5 <210> 1665 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC CDR3 <400> 1665 Gln Gln Ala His Ser Phe Pro Phe Thr 1 5 <210> 1666 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC CDR1 <400> 1666 Ser Tyr Tyr Met His 1 5 <210> 1667 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC CDR2 <400> 1667 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1668 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC CDR3 <400> 1668 Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr 1 5 10 <210> 1669 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC CDR1 <400> 1669 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 1670 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC CDR2 <400> 1670 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 1671 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC CDR3 <400> 1671 Gln Gln Ser Tyr Ser Thr Leu Pro Thr 1 5 <210> 1672 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC CDR1 <400> 1672 Ser Tyr Tyr Met His 1 5 <210> 1673 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC CDR2 <400> 1673 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1674 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC CDR3 <400> 1674 Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr 1 5 10 <210> 1675 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC CDR1 <400> 1675 Thr Gly Ser Ser Ser Asn Thr Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1676 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC CDR2 <400> 1676 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1677 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC CDR3 <400> 1677 Ala Ala Trp Asp Asp Ser Leu Asn Gly Gly Val 1 5 10 <210> 1678 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC CDR1 <400> 1678 Ser Asn Tyr Met Ser 1 5 <210> 1679 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC CDR2 <400> 1679 Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1680 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC CDR3 <400> 1680 Asp Leu Ile Val Tyr Gly Met Asp Val 1 5 <210> 1681 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.281 LC CDR1 <400> 1681 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1682 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.281 LC CDR2 <400> 1682 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1683 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.281 LC CDR3 <400> 1683 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1684 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.281 HC CDR1 <400> 1684 Ser Asn Tyr Met Ser 1 5 <210> 1685 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.281 HC CDR2 <400> 1685 Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1686 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.281 HC CDR3 <400> 1686 Asp Leu Ile Val Tyr Gly Met Asp Val 1 5 <210> 1687 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC CDR1 <400> 1687 Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1688 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC CDR2 <400> 1688 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1689 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC CDR3 <400> 1689 Ala Ala Trp Asp Asp Ser Leu Asn Gly Gly Val 1 5 10 <210> 1690 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC CDR1 <400> 1690 Ser Asn Tyr Met Ser 1 5 <210> 1691 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC CDR2 <400> 1691 Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1692 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC CDR3 <400> 1692 Asp Leu Ile Val Tyr Gly Met Asp Val 1 5 <210> 1693 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC CDR1 <400> 1693 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 1694 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC CDR2 <400> 1694 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 1695 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC CDR3 <400> 1695 Gln Gln Tyr Gly Ser Ser Pro Pro Tyr Thr 1 5 10 <210> 1696 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC CDR1 <400> 1696 Ser Asn Tyr Met Ser 1 5 <210> 1697 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC CDR2 <400> 1697 Val Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1698 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC CDR3 <400> 1698 Asp Leu Arg Gly Val Leu Asp Tyr 1 5 <210> 1699 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC CDR1 <400> 1699 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1700 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC CDR2 <400> 1700 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1701 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC CDR3 <400> 1701 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1702 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC CDR1 <400> 1702 Ser Asn Tyr Met Ser 1 5 <210> 1703 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC CDR2 <400> 1703 Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1704 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC CDR3 <400> 1704 Gly His Val Asp Ile Pro Tyr Gly Met Asp Val 1 5 10 <210> 1705 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC CDR1 <400> 1705 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1706 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC CDR2 <400> 1706 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1707 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC CDR3 <400> 1707 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1708 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC CDR1 <400> 1708 Ser Tyr Ala Ile Ser 1 5 <210> 1709 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC CDR2 <400> 1709 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1710 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC CDR3 <400> 1710 Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp Pro 1 5 10 15 <210> 1711 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC CDR1 <400> 1711 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1712 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC CDR2 <400> 1712 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1713 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC CDR3 <400> 1713 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1714 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC CDR1 <400> 1714 Ser Tyr Ala Ile Ser 1 5 <210> 1715 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC CDR2 <400> 1715 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1716 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC CDR3 <400> 1716 Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp Pro 1 5 10 15 <210> 1717 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC CDR1 <400> 1717 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1718 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC CDR2 <400> 1718 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1719 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC CDR3 <400> 1719 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1720 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC CDR1 <400> 1720 Ser Tyr Ala Ile Ser 1 5 <210> 1721 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC CDR2 <400> 1721 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1722 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC CDR3 <400> 1722 Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 1 5 10 <210> 1723 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC CDR1 <400> 1723 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 1724 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC CDR2 <400> 1724 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 1725 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC CDR3 <400> 1725 Gln Ser Tyr Asp Ser Ser Asn His Trp Val 1 5 10 <210> 1726 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC CDR1 <400> 1726 Ser Tyr Ala Met His 1 5 <210> 1727 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC CDR2 <400> 1727 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1728 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC CDR3 <400> 1728 Ala Asn Leu Gly Tyr Cys Thr Asn Gly Val Cys Ala Pro Ser Gly Gly 1 5 10 15 <210> 1729 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC CDR1 <400> 1729 Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1730 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC CDR2 <400> 1730 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1731 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC CDR3 <400> 1731 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 1732 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC CDR1 <400> 1732 Asp Tyr Ala Met His 1 5 <210> 1733 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC CDR2 <400> 1733 Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1734 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC CDR3 <400> 1734 Asn Leu Arg Tyr Phe Asp Trp Leu Leu Gly Asp Asp Ala Phe Asp Ile 1 5 10 15 <210> 1735 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC CDR1 <400> 1735 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1736 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC CDR2 <400> 1736 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1737 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC CDR3 <400> 1737 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1738 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC CDR1 <400> 1738 Ser Asn Tyr Met Thr 1 5 <210> 1739 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC CDR2 <400> 1739 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1740 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC CDR3 <400> 1740 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1741 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.1 LC variable region <400> 1741 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1742 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.1 HC variable region <400> 1742 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu 100 105 110 Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 1743 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.2 LC variable region <400> 1743 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Val Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro His 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1744 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.2 HC variable region <400> 1744 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu 100 105 110 Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 1745 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.3 LC variable region <400> 1745 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1746 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.3 HC variable region <400> 1746 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr 100 105 110 Ser Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1747 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.4 LC variable region <400> 1747 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asp Leu Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1748 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.4 HC variable region <400> 1748 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr 100 105 110 Ser Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1749 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.5 LC variable region <400> 1749 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1750 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.5 HC variable region <400> 1750 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr 100 105 110 Ser Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1751 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.6 LC variable region <400> 1751 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1752 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.6 HC variable region <400> 1752 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1753 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.7 LC variable region <400> 1753 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1754 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.7 HC variable region <400> 1754 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1755 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC variable region <400> 1755 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1756 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC variable region <400> 1756 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1757 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.9 LC variable region <400> 1757 Glu Leu Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1758 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.9 HC variable region <400> 1758 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1759 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC variable region <400> 1759 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1760 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC variable region <400> 1760 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1761 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.11 LC variable region <400> 1761 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1762 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.11 HC variable region <400> 1762 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1763 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.12 LC variable region <400> 1763 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1764 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.12 HC variable region <400> 1764 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1765 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.13 LC variable region <400> 1765 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Gly Asn Tyr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1766 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.13 HC variable region <400> 1766 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1767 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.14 LC variable region <400> 1767 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 20 25 30 Tyr Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Arg Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1768 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.14 HC variable region <400> 1768 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1769 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.15 LC variable region <400> 1769 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1770 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.15 HC variable region <400> 1770 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1771 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC variable region <400> 1771 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1772 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC variable region <400> 1772 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1773 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC variable region <400> 1773 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1774 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC variable region <400> 1774 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1775 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.18 LC variable region <400> 1775 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1776 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.18 HC variable region <400> 1776 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1777 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC variable region <400> 1777 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1778 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.19 HC variable region <400> 1778 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1779 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.20 LC variable region <400> 1779 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1780 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.20 HC variable region <400> 1780 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1781 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC variable region <400> 1781 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1782 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC variable region <400> 1782 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1783 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.22 LC variable region <400> 1783 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1784 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.22 HC variable region <400> 1784 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1785 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC variable region <400> 1785 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1786 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.23 HC variable region <400> 1786 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1787 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.24 LC variable region <400> 1787 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1788 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.24 HC variable region <400> 1788 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1789 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC variable region <400> 1789 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1790 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC variable region <400> 1790 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1791 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC variable region <400> 1791 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1792 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC variable region <400> 1792 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1793 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC variable region <400> 1793 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1794 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC variable region <400> 1794 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1795 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC variable region <400> 1795 Glu Leu Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1796 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC variable region <400> 1796 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1797 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC variable region <400> 1797 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1798 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC variable region <400> 1798 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1799 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.30 LC variable region <400> 1799 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1800 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.30 HC variable region <400> 1800 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1801 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.31 LC variable region <400> 1801 Glu Leu Gly Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 20 25 30 Tyr Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1802 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.31 HC variable region <400> 1802 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1803 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC variable region <400> 1803 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1804 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC variable region <400> 1804 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1805 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC variable region <400> 1805 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1806 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC variable region <400> 1806 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1807 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC variable region <400> 1807 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1808 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC variable region <400> 1808 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1809 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC variable region <400> 1809 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1810 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC variable region <400> 1810 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1811 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC variable region <400> 1811 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1812 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC variable region <400> 1812 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1813 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC variable region <400> 1813 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1814 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC variable region <400> 1814 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1815 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC variable region <400> 1815 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1816 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.38 HC variable region <400> 1816 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1817 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC variable region <400> 1817 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1818 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC variable region <400> 1818 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1819 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.40 LC variable region <400> 1819 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1820 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.40 HC variable region <400> 1820 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1821 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC variable region <400> 1821 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1822 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC variable region <400> 1822 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1823 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC variable region <400> 1823 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1824 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC variable region <400> 1824 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1825 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC variable region <400> 1825 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1826 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC variable region <400> 1826 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1827 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC variable region <400> 1827 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Val Thr Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1828 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC variable region <400> 1828 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Arg Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Pro Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1829 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC variable region <400> 1829 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1830 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC variable region <400> 1830 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1831 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC variable region <400> 1831 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1832 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC variable region <400> 1832 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1833 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC variable region <400> 1833 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1834 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC variable region <400> 1834 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1835 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC variable region <400> 1835 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1836 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC variable region <400> 1836 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Ser His Tyr 20 25 30 Phe Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly 100 105 110 Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1837 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.49 LC variable region <400> 1837 Glu Leu Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1838 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.49 HC variable region <400> 1838 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1839 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC variable region <400> 1839 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1840 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC variable region <400> 1840 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1841 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC variable region <400> 1841 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1842 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC variable region <400> 1842 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1843 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.52 LC variable region <400> 1843 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1844 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.52 HC variable region <400> 1844 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1845 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC variable region <400> 1845 Glu Leu Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Gly Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Ala Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1846 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC variable region <400> 1846 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1847 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC variable region <400> 1847 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Ala Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr His Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1848 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC variable region <400> 1848 Arg Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1849 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC variable region <400> 1849 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1850 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC variable region <400> 1850 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1851 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC variable region <400> 1851 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 1852 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC variable region <400> 1852 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1853 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.57 LC variable region <400> 1853 Glu Leu Val Met Thr Gln Ser Pro Gly Ile Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1854 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.57 HC variable region <400> 1854 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1855 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.58 LC variable region <400> 1855 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1856 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.58 HC variable region <400> 1856 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1857 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC variable region <400> 1857 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1858 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC variable region <400> 1858 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1859 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC variable region <400> 1859 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Pro Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1860 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.60 HC variable region <400> 1860 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1861 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC variable region <400> 1861 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Ser 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1862 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC variable region <400> 1862 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1863 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC variable region <400> 1863 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1864 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC variable region <400> 1864 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1865 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC variable region <400> 1865 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1866 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC variable region <400> 1866 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Val Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1867 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC variable region <400> 1867 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1868 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC variable region <400> 1868 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1869 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC variable region <400> 1869 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Ser Ala Thr Leu Ala Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Phe Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 1870 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC variable region <400> 1870 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1871 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC variable region <400> 1871 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1872 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC variable region <400> 1872 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1873 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC variable region <400> 1873 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1874 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC variable region <400> 1874 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1875 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC variable region <400> 1875 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Pro Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 1876 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC variable region <400> 1876 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Val Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1877 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC variable region <400> 1877 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile His Ala Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Val Glu 65 70 75 80 Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asp Ser Leu 85 90 95 Ser Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1878 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC variable region <400> 1878 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1879 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.70 LC variable region <400> 1879 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1880 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.70 HC variable region <400> 1880 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1881 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC variable region <400> 1881 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1882 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC variable region <400> 1882 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1883 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC variable region <400> 1883 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met 35 40 45 Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 65 70 75 80 Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser Ser 85 90 95 Thr Leu Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 <210> 1884 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC variable region <400> 1884 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1885 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC variable region <400> 1885 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Ser Ala Thr Leu Ala Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Phe Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 1886 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC variable region <400> 1886 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Pro Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1887 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC variable region <400> 1887 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1888 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC variable region <400> 1888 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1889 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC variable region <400> 1889 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1890 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC variable region <400> 1890 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1891 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC variable region <400> 1891 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1892 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC variable region <400> 1892 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1893 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC variable region <400> 1893 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1894 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC variable region <400> 1894 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1895 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC variable region <400> 1895 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1896 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC variable region <400> 1896 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1897 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC variable region <400> 1897 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Ser 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1898 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC variable region <400> 1898 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1899 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC variable region <400> 1899 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1900 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC variable region <400> 1900 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1901 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC variable region <400> 1901 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1902 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC variable region <400> 1902 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1903 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC variable region <400> 1903 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1904 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC variable region <400> 1904 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1905 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC variable region <400> 1905 Glu Leu Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1906 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC variable region <400> 1906 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1907 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC variable region <400> 1907 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1908 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC variable region <400> 1908 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Val Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1909 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC variable region <400> 1909 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1910 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC variable region <400> 1910 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1911 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC variable region <400> 1911 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Arg Ala Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1912 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC variable region <400> 1912 Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1913 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC variable region <400> 1913 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1914 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC variable region <400> 1914 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1915 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC variable region <400> 1915 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser 85 90 95 Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1916 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC variable region <400> 1916 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 1917 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC variable region <400> 1917 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Arg Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1918 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC variable region <400> 1918 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1919 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC variable region <400> 1919 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1920 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC variable region <400> 1920 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1921 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC variable region <400> 1921 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1922 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC variable region <400> 1922 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ala Gln 1 5 10 15 Thr Leu Arg Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Phe Ser 115 120 125 <210> 1923 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC variable region <400> 1923 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1924 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC variable region <400> 1924 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1925 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC variable region <400> 1925 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Arg Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1926 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC variable region <400> 1926 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Val Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1927 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC variable region <400> 1927 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1928 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC variable region <400> 1928 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1929 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC variable region <400> 1929 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1930 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC variable region <400> 1930 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1931 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.96 LC variable region <400> 1931 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1932 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.96 HC variable region <400> 1932 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1933 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC variable region <400> 1933 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1934 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC variable region <400> 1934 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1935 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.98 LC variable region <400> 1935 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1936 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.98 HC variable region <400> 1936 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1937 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC variable region <400> 1937 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1938 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC variable region <400> 1938 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1939 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC variable region <400> 1939 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1940 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.100 HC variable region <400> 1940 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1941 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.101 LC variable region <400> 1941 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1942 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.101 HC variable region <400> 1942 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1943 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC variable region <400> 1943 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1944 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC variable region <400> 1944 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1945 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC variable region <400> 1945 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1946 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC variable region <400> 1946 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1947 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC variable region <400> 1947 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1948 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC variable region <400> 1948 Gln Val Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1949 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC variable region <400> 1949 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1950 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC variable region <400> 1950 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1951 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC variable region <400> 1951 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1952 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC variable region <400> 1952 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1953 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC variable region <400> 1953 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1954 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC variable region <400> 1954 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1955 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC variable region <400> 1955 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1956 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC variable region <400> 1956 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1957 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC variable region <400> 1957 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1958 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC variable region <400> 1958 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1959 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC variable region <400> 1959 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1960 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.110 HC variable region <400> 1960 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1961 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC variable region <400> 1961 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1962 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC variable region <400> 1962 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1963 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC variable region <400> 1963 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1964 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC variable region <400> 1964 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1965 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC variable region <400> 1965 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Ile Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1966 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC variable region <400> 1966 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1967 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC variable region <400> 1967 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1968 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC variable region <400> 1968 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1969 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC variable region <400> 1969 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1970 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC variable region <400> 1970 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1971 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC variable region <400> 1971 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1972 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC variable region <400> 1972 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1973 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC variable region <400> 1973 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1974 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC variable region <400> 1974 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1975 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC variable region <400> 1975 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1976 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC variable region <400> 1976 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1977 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC variable region <400> 1977 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1978 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC variable region <400> 1978 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1979 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.120 LC variable region <400> 1979 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1980 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.120 HC variable region <400> 1980 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Thr Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1981 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC variable region <400> 1981 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1982 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC variable region <400> 1982 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1983 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC variable region <400> 1983 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1984 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC variable region <400> 1984 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1985 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC variable region <400> 1985 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1986 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC variable region <400> 1986 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1987 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC variable region <400> 1987 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1988 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC variable region <400> 1988 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ala Gln 1 5 10 15 Thr Leu Arg Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Phe Ser 115 120 125 <210> 1989 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC variable region <400> 1989 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1990 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC variable region <400> 1990 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1991 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC variable region <400> 1991 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1992 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC variable region <400> 1992 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1993 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC variable region <400> 1993 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1994 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC variable region <400> 1994 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ala Gln 1 5 10 15 Thr Leu Arg Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Phe Ser 115 120 125 <210> 1995 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC variable region <400> 1995 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn 20 25 30 Phe Val Ser Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1996 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.128 HC variable region <400> 1996 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1997 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC variable region <400> 1997 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Ser Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Asn Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1998 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC variable region <400> 1998 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1999 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.130 LC variable region <400> 1999 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2000 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.130 HC variable region <400> 2000 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2001 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC variable region <400> 2001 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2002 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC variable region <400> 2002 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2003 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC variable region <400> 2003 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2004 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC variable region <400> 2004 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2005 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC variable region <400> 2005 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2006 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC variable region <400> 2006 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2007 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC variable region <400> 2007 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2008 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC variable region <400> 2008 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2009 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC variable region <400> 2009 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2010 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC variable region <400> 2010 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2011 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC variable region <400> 2011 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2012 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC variable region <400> 2012 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2013 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC variable region <400> 2013 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2014 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC variable region <400> 2014 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2015 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC variable region <400> 2015 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2016 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC variable region <400> 2016 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2017 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC variable region <400> 2017 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2018 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC variable region <400> 2018 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr His Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2019 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.140 LC variable region <400> 2019 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2020 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.140 HC variable region <400> 2020 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2021 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC variable region <400> 2021 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2022 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC variable region <400> 2022 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2023 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC variable region <400> 2023 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2024 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC variable region <400> 2024 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2025 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC variable region <400> 2025 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2026 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC variable region <400> 2026 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2027 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC variable region <400> 2027 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2028 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC variable region <400> 2028 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2029 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC variable region <400> 2029 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2030 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC variable region <400> 2030 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2031 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC variable region <400> 2031 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2032 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC variable region <400> 2032 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2033 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC variable region <400> 2033 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2034 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC variable region <400> 2034 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Phe Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2035 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC variable region <400> 2035 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2036 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC variable region <400> 2036 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2037 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC variable region <400> 2037 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2038 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC variable region <400> 2038 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2039 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC variable region <400> 2039 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2040 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC variable region <400> 2040 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2041 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC variable region <400> 2041 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2042 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC variable region <400> 2042 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2043 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC variable region <400> 2043 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2044 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC variable region <400> 2044 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2045 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC variable region <400> 2045 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2046 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC variable region <400> 2046 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2047 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC variable region <400> 2047 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2048 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC variable region <400> 2048 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2049 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC variable region <400> 2049 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2050 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC variable region <400> 2050 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2051 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC variable region <400> 2051 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2052 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC variable region <400> 2052 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2053 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC variable region <400> 2053 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2054 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC variable region <400> 2054 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2055 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC variable region <400> 2055 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2056 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC variable region <400> 2056 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2057 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC variable region <400> 2057 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2058 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC variable region <400> 2058 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2059 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.160 LC variable region <400> 2059 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2060 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.160 HC variable region <400> 2060 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2061 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC variable region <400> 2061 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2062 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC variable region <400> 2062 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2063 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC variable region <400> 2063 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2064 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC variable region <400> 2064 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2065 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC variable region <400> 2065 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2066 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC variable region <400> 2066 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2067 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC variable region <400> 2067 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2068 <211> 133 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC variable region <400> 2068 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Pro Arg Asp His Gly His Arg Leu Leu 115 120 125 Ser Phe His Gln Gly 130 <210> 2069 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC variable region <400> 2069 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2070 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC variable region <400> 2070 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2071 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC variable region <400> 2071 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2072 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC variable region <400> 2072 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2073 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC variable region <400> 2073 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2074 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC variable region <400> 2074 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2075 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC variable region <400> 2075 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2076 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC variable region <400> 2076 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2077 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC variable region <400> 2077 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2078 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC variable region <400> 2078 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2079 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC variable region <400> 2079 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2080 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC variable region <400> 2080 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2081 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC variable region <400> 2081 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2082 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC variable region <400> 2082 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2083 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.172 LC variable region <400> 2083 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Ala Leu 100 105 110 <210> 2084 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC variable region <400> 2084 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Pro Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2085 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC variable region <400> 2085 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2086 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC variable region <400> 2086 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2087 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC variable region <400> 2087 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2088 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC variable region <400> 2088 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2089 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC variable region <400> 2089 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2090 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC variable region <400> 2090 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2091 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC variable region <400> 2091 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2092 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC variable region <400> 2092 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2093 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC variable region <400> 2093 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2094 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC variable region <400> 2094 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2095 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC variable region <400> 2095 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2096 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC variable region <400> 2096 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2097 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC variable region <400> 2097 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2098 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC variable region <400> 2098 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2099 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC variable region <400> 2099 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2100 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC variable region <400> 2100 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2101 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC variable region <400> 2101 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2102 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC variable region <400> 2102 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2103 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC variable region <400> 2103 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2104 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC variable region <400> 2104 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2105 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC variable region <400> 2105 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2106 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC variable region <400> 2106 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2107 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC variable region <400> 2107 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Arg Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2108 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC variable region <400> 2108 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2109 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC variable region <400> 2109 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2110 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC variable region <400> 2110 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2111 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC variable region <400> 2111 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2112 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC variable region <400> 2112 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2113 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC variable region <400> 2113 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2114 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC variable region <400> 2114 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2115 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC variable region <400> 2115 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2116 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC variable region <400> 2116 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2117 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC variable region <400> 2117 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2118 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC variable region <400> 2118 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2119 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC variable region <400> 2119 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2120 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC variable region <400> 2120 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2121 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.191 LC variable region <400> 2121 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2122 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.191 HC variable region <400> 2122 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2123 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC variable region <400> 2123 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2124 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC variable region <400> 2124 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2125 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC variable region <400> 2125 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2126 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC variable region <400> 2126 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2127 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC variable region <400> 2127 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2128 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC variable region <400> 2128 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2129 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC variable region <400> 2129 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asp Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2130 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC variable region <400> 2130 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Thr Arg Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Leu Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Gly Ile Ala Val Ala Gly Thr Pro Ile Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2131 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC variable region <400> 2131 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2132 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC variable region <400> 2132 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2133 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC variable region <400> 2133 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2134 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC variable region <400> 2134 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Glu Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2135 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC variable region <400> 2135 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Ala Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2136 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC variable region <400> 2136 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2137 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC variable region <400> 2137 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2138 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC variable region <400> 2138 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Glu Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2139 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC variable region <400> 2139 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2140 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC variable region <400> 2140 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2141 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC variable region <400> 2141 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2142 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC variable region <400> 2142 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2143 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC variable region <400> 2143 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2144 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC variable region <400> 2144 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2145 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC variable region <400> 2145 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2146 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC variable region <400> 2146 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2147 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC variable region <400> 2147 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2148 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC variable region <400> 2148 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2149 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC variable region <400> 2149 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2150 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC variable region <400> 2150 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2151 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC variable region <400> 2151 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2152 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC variable region <400> 2152 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2153 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC variable region <400> 2153 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ala Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2154 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC variable region <400> 2154 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2155 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC variable region <400> 2155 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2156 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC variable region <400> 2156 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2157 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC variable region <400> 2157 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Ala Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2158 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC variable region <400> 2158 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2159 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC variable region <400> 2159 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2160 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC variable region <400> 2160 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2161 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC variable region <400> 2161 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Gly Asn 20 25 30 Thr Val Asn Trp Phe Gln Gln Leu Pro Gly Ala Val Pro Lys Leu Leu 35 40 45 Val Tyr Gly Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2162 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC variable region <400> 2162 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2163 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC variable region <400> 2163 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Glu Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2164 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC variable region <400> 2164 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Arg Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2165 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC variable region <400> 2165 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2166 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC variable region <400> 2166 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2167 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC variable region <400> 2167 Glu Leu Met Leu Thr Gln Pro His Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Thr Leu 85 90 95 Asp Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2168 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC variable region <400> 2168 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Pro Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2169 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC variable region <400> 2169 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2170 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC variable region <400> 2170 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2171 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC variable region <400> 2171 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2172 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC variable region <400> 2172 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2173 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC variable region <400> 2173 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Val Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2174 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC variable region <400> 2174 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2175 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC variable region <400> 2175 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Ser Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn 20 25 30 Pro Val Asn Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asn Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2176 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC variable region <400> 2176 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2177 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC variable region <400> 2177 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Phe Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Val Ser 50 55 60 Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Gly Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2178 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC variable region <400> 2178 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2179 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC variable region <400> 2179 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2180 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.220 HC variable region <400> 2180 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Pro Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2181 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC variable region <400> 2181 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2182 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC variable region <400> 2182 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2183 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC variable region <400> 2183 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ala Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2184 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC variable region <400> 2184 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2185 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC variable region <400> 2185 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2186 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC variable region <400> 2186 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2187 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC variable region <400> 2187 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2188 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC variable region <400> 2188 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2189 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC variable region <400> 2189 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2190 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC variable region <400> 2190 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2191 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC variable region <400> 2191 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2192 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC variable region <400> 2192 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2193 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC variable region <400> 2193 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2194 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC variable region <400> 2194 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2195 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC variable region <400> 2195 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Leu Ser Cys Ser Gly Ser Ser Ser Asn Val Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2196 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC variable region <400> 2196 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2197 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC variable region <400> 2197 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2198 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC variable region <400> 2198 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2199 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC variable region <400> 2199 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2200 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC variable region <400> 2200 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2201 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC variable region <400> 2201 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2202 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC variable region <400> 2202 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2203 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC variable region <400> 2203 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2204 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC variable region <400> 2204 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2205 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.233 LC variable region <400> 2205 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2206 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.233 HC variable region <400> 2206 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2207 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC variable region <400> 2207 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2208 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC variable region <400> 2208 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2209 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC variable region <400> 2209 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2210 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC variable region <400> 2210 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2211 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC variable region <400> 2211 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Asn Ser 85 90 95 Glu Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2212 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC variable region <400> 2212 Glu Val Gln Leu Leu Glu Ser Arg Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2213 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC variable region <400> 2213 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2214 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC variable region <400> 2214 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2215 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC variable region <400> 2215 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2216 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC variable region <400> 2216 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2217 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC variable region <400> 2217 Asp Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Met Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2218 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC variable region <400> 2218 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2219 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC variable region <400> 2219 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2220 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC variable region <400> 2220 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Pro Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2221 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.241 LC variable region <400> 2221 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn 20 25 30 Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Leu Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2222 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.241 HC variable region <400> 2222 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2223 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.242 LC variable region <400> 2223 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2224 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.242 HC variable region <400> 2224 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Glu Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2225 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.243 LC variable region <400> 2225 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2226 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.243 HC variable region <400> 2226 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2227 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC variable region <400> 2227 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2228 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC variable region <400> 2228 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2229 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC variable region <400> 2229 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2230 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC variable region <400> 2230 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2231 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC variable region <400> 2231 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Pro Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2232 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC variable region <400> 2232 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2233 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC variable region <400> 2233 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser 65 70 75 80 Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser 85 90 95 Gly Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 <210> 2234 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC variable region <400> 2234 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2235 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC variable region <400> 2235 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2236 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC variable region <400> 2236 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Thr Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2237 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC variable region <400> 2237 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Gly Ser Ser Asp His 85 90 95 Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 <210> 2238 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC variable region <400> 2238 Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 1 5 10 15 Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 35 40 45 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Lys Leu Ser His Gly Val Val Gly Ala Gln Asp Ala Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 2239 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC variable region <400> 2239 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2240 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC variable region <400> 2240 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2241 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC variable region <400> 2241 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2242 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC variable region <400> 2242 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2243 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC variable region <400> 2243 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2244 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC variable region <400> 2244 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2245 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC variable region <400> 2245 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2246 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC variable region <400> 2246 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2247 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC variable region <400> 2247 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 85 90 95 Pro Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 <210> 2248 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC variable region <400> 2248 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2249 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC variable region <400> 2249 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asn His Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 100 105 110 <210> 2250 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC variable region <400> 2250 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2251 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC variable region <400> 2251 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2252 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC variable region <400> 2252 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2253 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC variable region <400> 2253 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2254 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC variable region <400> 2254 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2255 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC variable region <400> 2255 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2256 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC variable region <400> 2256 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2257 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC variable region <400> 2257 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2258 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC variable region <400> 2258 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2259 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC variable region <400> 2259 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Leu Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2260 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC variable region <400> 2260 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Ile Val Ser Ser 115 120 <210> 2261 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC variable region <400> 2261 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2262 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.261 HC variable region <400> 2262 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2263 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC variable region <400> 2263 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 85 90 95 Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2264 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC variable region <400> 2264 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2265 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC variable region <400> 2265 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Pro Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2266 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC variable region <400> 2266 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2267 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC variable region <400> 2267 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2268 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC variable region <400> 2268 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2269 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC variable region <400> 2269 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2270 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC variable region <400> 2270 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2271 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC variable region <400> 2271 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Arg Asp Ser Ser Ser Asp His 85 90 95 Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 2272 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC variable region <400> 2272 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2273 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC variable region <400> 2273 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2274 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC variable region <400> 2274 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2275 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC variable region <400> 2275 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Asp Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Asn Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Gln Ser Ser Asp Ser Gly 85 90 95 Leu Thr Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2276 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC variable region <400> 2276 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2277 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC variable region <400> 2277 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ala Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2278 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC variable region <400> 2278 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2279 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC variable region <400> 2279 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2280 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC variable region <400> 2280 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2281 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC variable region <400> 2281 Glu Leu Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Asn 85 90 95 Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> 2282 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC variable region <400> 2282 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2283 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC variable region <400> 2283 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2284 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC variable region <400> 2284 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2285 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC variable region <400> 2285 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2286 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC variable region <400> 2286 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2287 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC variable region <400> 2287 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2288 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC variable region <400> 2288 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2289 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC variable region <400> 2289 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Asn Thr Val 20 25 30 Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 35 40 45 Ser Asn Asn Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 50 55 60 Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly 85 90 95 Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 2290 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC variable region <400> 2290 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2291 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC variable region <400> 2291 Glu Leu Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Ser 20 25 30 Asp Val Gly Trp Tyr Gln His Leu Pro Gly Met Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Lys Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu 85 90 95 Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 2292 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC variable region <400> 2292 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2293 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC variable region <400> 2293 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2294 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC variable region <400> 2294 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2295 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC variable region <400> 2295 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Gly Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Phe Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2296 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC variable region <400> 2296 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2297 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC variable region <400> 2297 Glu Leu Thr Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Pro 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 2298 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC variable region <400> 2298 Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2299 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC variable region <400> 2299 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Thr Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Asn Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2300 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC variable region <400> 2300 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Ile Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2301 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.281 LC variable region <400> 2301 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2302 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.281 HC variable region <400> 2302 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Ile Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2303 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC variable region <400> 2303 Glu Leu Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Asn Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2304 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC variable region <400> 2304 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Ile Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2305 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC variable region <400> 2305 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Pro 85 90 95 Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2306 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC variable region <400> 2306 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 2307 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC variable region <400> 2307 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2308 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC variable region <400> 2308 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg His Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly His Val Asp Ile Pro Tyr Gly Met Asp Val Trp Gly Gln Gly 100 105 110 Thr Thr Val Thr Val Ser Ser 115 <210> 2309 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC variable region <400> 2309 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2310 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC variable region <400> 2310 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp 100 105 110 Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2311 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC variable region <400> 2311 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2312 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC variable region <400> 2312 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp 100 105 110 Pro Trp Gly Gln Gly Thr Leu Val Thr Val Pro Ser 115 120 <210> 2313 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC variable region <400> 2313 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2314 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC variable region <400> 2314 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2315 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC variable region <400> 2315 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2316 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC variable region <400> 2316 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Asn Leu Gly Tyr Cys Thr Asn Gly Val Cys Ala Pro Ser 100 105 110 Gly Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2317 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC variable region <400> 2317 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2318 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC variable region <400> 2318 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asn Leu Arg Tyr Phe Asp Trp Leu Leu Gly Asp Asp Ala Phe 100 105 110 Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 2319 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC variable region <400> 2319 Glu Leu Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2320 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC variable region <400> 2320 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2321 <211> 1273 <212> PRT <213> Artificial Sequence <220> <223> SARS-CoV-2 virus spike protein sequence <400> 2321 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 1010 1015 1020 Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 1025 1030 1035 1040 Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 1045 1050 1055 Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 1060 1065 1070 Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 1075 1080 1085 Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 1090 1095 1100 Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 1105 1110 1115 1120 Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 1125 1130 1135 Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 1140 1145 1150 Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 1155 1160 1165 Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 1170 1175 1180 Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 1185 1190 1195 1200 Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 1205 1210 1215 Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 1220 1225 1230 Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 1235 1240 1245 Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 1250 1255 1260 Leu Lys Gly Val Lys Leu His Tyr Thr 1265 1270 <110> CELLTRION, INC. <120> SARS-CoV-2 NEUTRALIZING BINDING MOLECULE BINDING TO EPITOPES OF SARS-CoV-2 SPIKE PROTEIN <130> CPD2021050KR <150> KR 10-2020-0091979 <151> 2020-07-23 <150> KR 10-2020-0104969 <151> 2020-08-20 <150> KR 10-2020-0152212 <151> 2020-11-13 <150> KR 10-2021-0019449 <151> 2021-02-10 <150> KR 10-2021-0040750 <151> 2021-03-29 <150> KR 10-2021-0075093 <151> 2021-06-09 <160> 2321 <170> KoPatentIn 3.0 <210> 1 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 1 LC CDR1 <400> 1 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 2 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 1 LC CDR2 <400> 2 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 3 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 1 LC CDR3 <400> 3 Gln Gln Ser Tyr Ser Thr Pro Phe Thr 1 5 <210> 4 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 1 HC CDR1 <400> 4 Asp Tyr Ala Met His 1 5 <210> 5 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 1 HC CDR2 <400> 5 Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 6 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 1 HC CDR3 <400> 6 Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu Asp Ala 1 5 10 15 Phe Asp Ile <210> 7 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 2 LC CDR1 <400> 7 Arg Ala Ser Gln Ser Ile Ser Thr Tyr Leu Asn 1 5 10 <210> 8 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 2 LC CDR2 <400> 8 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 9 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 2 LC CDR3 <400> 9 Gln Gln Ser Tyr Ser Ile Pro His Thr 1 5 <210> 10 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 2 HC CDR1 <400> 10 Asp Tyr Ala Met His 1 5 <210> 11 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 2 HC CDR2 <400> 11 Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 12 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 2 HC CDR3 <400> 12 Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu Asp Ala 1 5 10 15 Phe Asp Ile <210> 13 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 3 LC CDR1 <400> 13 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 14 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 3 LC CDR2 <400> 14 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 15 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 3 LC CDR3 <400> 15 Gln Gln Tyr Asp Asn Leu Pro Ile Thr 1 5 <210> 16 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 3 HC CDR1 <400> 16 Ser Tyr Ala Met Ser 1 5 <210> 17 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 3 HC CDR2 <400> 17 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 18 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 3 HC CDR3 <400> 18 Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr Ser Trp 1 5 10 15 Phe Asp Pro <210> 19 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 4 LC CDR1 <400> 19 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 20 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 4 LC CDR2 <400> 20 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 21 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 4 LC CDR3 <400> 21 Gln Gln Tyr Asp Asp Leu Pro Ile Thr 1 5 <210> 22 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 4 HC CDR1 <400> 22 Ser Tyr Ala Met Ser 1 5 <210> 23 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 4 HC CDR2 <400> 23 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 24 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 4 HC CDR3 <400> 24 Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr Ser Trp 1 5 10 15 Phe Asp Pro <210> 25 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 5 LC CDR1 <400> 25 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 26 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 5 LC CDR2 <400> 26 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 27 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 5 LC CDR3 <400> 27 Gln Gln Tyr Asp Asn Leu Pro Ile Thr 1 5 <210> 28 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 5 HC CDR1 <400> 28 Ser Tyr Ala Met Ser 1 5 <210> 29 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 5 HC CDR2 <400> 29 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 30 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 5 HC CDR3 <400> 30 Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr Ser Trp 1 5 10 15 Phe Asp Pro <210> 31 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 6 LC CDR1 <400> 31 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 32 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 6 LC CDR2 <400> 32 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 33 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 6 LC CDR3 <400> 33 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 34 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 6 HC CDR1 <400> 34 Ser Tyr Ala Ile Ser 1 5 <210> 35 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 6 HC CDR2 <400> 35 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 36 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 6 HC CDR3 <400> 36 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 37 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 7 LC CDR1 <400> 37 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 38 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 7 LC CDR2 <400> 38 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 39 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 7 LC CDR3 <400> 39 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 40 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 7 HC CDR1 <400> 40 Ser Tyr Ala Ile Ser 1 5 <210> 41 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 7 HC CDR2 <400> 41 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 42 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 7 HC CDR3 <400> 42 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 43 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC CDR1 <400> 43 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 44 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC CDR2 <400> 44 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 45 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC CDR3 <400> 45 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 46 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC CDR1 <400> 46 Ser Tyr Ala Ile Ser 1 5 <210> 47 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC CDR2 <400> 47 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 48 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC CDR3 <400> 48 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 49 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 9 LC CDR1 <400> 49 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 50 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 9 LC CDR2 <400> 50 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 51 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 9 LC CDR3 <400> 51 Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 1 5 10 <210> 52 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 9 HC CDR1 <400> 52 Ser Tyr Ala Ile Ser 1 5 <210> 53 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 9 HC CDR2 <400> 53 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 54 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 9 HC CDR3 <400> 54 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 55 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC CDR1 <400> 55 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 56 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC CDR2 <400> 56 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 57 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC CDR3 <400> 57 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 58 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC CDR1 <400> 58 Ser Tyr Ala Ile Ser 1 5 <210> 59 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC CDR2 <400> 59 Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 60 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC CDR3 <400> 60 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 61 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 11 LC CDR1 <400> 61 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 62 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 11 LC CDR2 <400> 62 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 63 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 11 LC CDR3 <400> 63 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 64 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 11 HC CDR1 <400> 64 Ser Tyr Ala Ile Ser 1 5 <210> 65 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 11 HC CDR2 <400> 65 Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 66 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 11 HC CDR3 <400> 66 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 67 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.12 LC CDR1 <400> 67 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 68 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 12 LC CDR2 <400> 68 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 69 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 12 LC CDR3 <400> 69 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 70 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 12 HC CDR1 <400> 70 Ser Tyr Ala Ile Ser 1 5 <210> 71 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 12 HC CDR2 <400> 71 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 72 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.12 HC CDR3 <400> 72 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 73 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 13 LC CDR1 <400> 73 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Tyr 1 5 10 <210> 74 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 13 LC CDR2 <400> 74 Gly Asn Tyr Gln Arg Pro Ser 1 5 <210> 75 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 13 LC CDR3 <400> 75 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 76 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 13 HC CDR1 <400> 76 Ser Tyr Ala Ile Ser 1 5 <210> 77 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 13 HC CDR2 <400> 77 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 78 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 13 HC CDR3 <400> 78 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 79 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 14 LC CDR1 <400> 79 Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn Tyr Val His 1 5 10 <210> 80 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 14 LC CDR2 <400> 80 Ser Asn Asp Gln Arg Pro Ser 1 5 <210> 81 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 14 LC CDR3 <400> 81 Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 1 5 10 <210> 82 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 14 HC CDR1 <400> 82 Ser Tyr Ala Ile Ser 1 5 <210> 83 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 14 HC CDR2 <400> 83 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 84 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 14 HC CDR3 <400> 84 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 85 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.15 LC CDR1 <400> 85 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 86 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.15 LC CDR2 <400> 86 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 87 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 15 LC CDR3 <400> 87 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 88 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 15 HC CDR1 <400> 88 Ser Tyr Ala Ile Ser 1 5 <210> 89 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.15 HC CDR2 <400> 89 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 90 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.15 HC CDR3 <400> 90 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 91 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC CDR1 <400> 91 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 92 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC CDR2 <400> 92 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 93 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC CDR3 <400> 93 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 94 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC CDR1 <400> 94 Ser Tyr Ala Ile Ser 1 5 <210> 95 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC CDR2 <400> 95 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 96 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC CDR3 <400> 96 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 97 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC CDR1 <400> 97 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 98 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC CDR2 <400> 98 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 99 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC CDR3 <400> 99 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 100 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC CDR1 <400> 100 Ser Tyr Ala Ile Ser 1 5 <210> 101 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC CDR2 <400> 101 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 102 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC CDR3 <400> 102 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 103 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 18 LC CDR1 <400> 103 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 104 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 18 LC CDR2 <400> 104 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 105 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.18 LC CDR3 <400> 105 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Lys Val 1 5 10 <210> 106 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 18 HC CDR1 <400> 106 Ser Tyr Ala Ile Ser 1 5 <210> 107 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.18 HC CDR2 <400> 107 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 108 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 18 HC CDR3 <400> 108 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 109 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC CDR1 <400> 109 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 110 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC CDR2 <400> 110 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 111 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC CDR3 <400> 111 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 112 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 19 HC CDR1 <400> 112 Ser Tyr Ala Ile Ser 1 5 <210> 113 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 19 HC CDR2 <400> 113 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 114 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 19 HC CDR3 <400> 114 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 115 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 20 LC CDR1 <400> 115 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 116 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 20 LC CDR2 <400> 116 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 117 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 20 LC CDR3 <400> 117 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 118 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 20 HC CDR1 <400> 118 Ser Tyr Ala Ile Ser 1 5 <210> 119 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 20 HC CDR2 <400> 119 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 120 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 20 HC CDR3 <400> 120 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 121 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC CDR1 <400> 121 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 122 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC CDR2 <400> 122 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 123 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC CDR3 <400> 123 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 124 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC CDR1 <400> 124 Ser Tyr Ala Ile Ser 1 5 <210> 125 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC CDR2 <400> 125 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 126 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC CDR3 <400> 126 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 127 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 22 LC CDR1 <400> 127 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 128 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 22 LC CDR2 <400> 128 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 129 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.22 LC CDR3 <400> 129 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 130 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.22 HC CDR1 <400> 130 Ser Tyr Ala Ile Ser 1 5 <210> 131 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 22 HC CDR2 <400> 131 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 132 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 22 HC CDR3 <400> 132 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 133 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC CDR1 <400> 133 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 134 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC CDR2 <400> 134 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 135 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC CDR3 <400> 135 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 136 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 23 HC CDR1 <400> 136 Ser Tyr Ala Ile Ser 1 5 <210> 137 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.23 HC CDR2 <400> 137 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 138 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.23 HC CDR3 <400> 138 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 139 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 24 LC CDR1 <400> 139 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 140 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 24 LC CDR2 <400> 140 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 141 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 24 LC CDR3 <400> 141 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 142 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 24 HC CDR1 <400> 142 Ser Tyr Ala Ile Ser 1 5 <210> 143 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 24 HC CDR2 <400> 143 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 144 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 24 HC CDR3 <400> 144 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 145 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC CDR1 <400> 145 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 146 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC CDR2 <400> 146 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 147 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC CDR3 <400> 147 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 148 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC CDR1 <400> 148 Ser Tyr Ala Ile Ser 1 5 <210> 149 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC CDR2 <400> 149 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 150 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC CDR3 <400> 150 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 151 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC CDR1 <400> 151 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 152 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC CDR2 <400> 152 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 153 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC CDR3 <400> 153 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 154 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC CDR1 <400> 154 Ser Tyr Ala Ile Ser 1 5 <210> 155 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC CDR2 <400> 155 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 156 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC CDR3 <400> 156 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 157 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC CDR1 <400> 157 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 158 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC CDR2 <400> 158 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 159 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC CDR3 <400> 159 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 160 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC CDR1 <400> 160 Ser Tyr Ala Ile Ser 1 5 <210> 161 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC CDR2 <400> 161 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 162 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC CDR3 <400> 162 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 163 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC CDR1 <400> 163 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 164 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC CDR2 <400> 164 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 165 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC CDR3 <400> 165 Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Val 1 5 10 <210> 166 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC CDR1 <400> 166 Ser Tyr Ala Ile Ser 1 5 <210> 167 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC CDR2 <400> 167 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 168 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC CDR3 <400> 168 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 169 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC CDR1 <400> 169 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 170 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC CDR2 <400> 170 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 171 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC CDR3 <400> 171 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 172 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC CDR1 <400> 172 Ser Tyr Ala Ile Ser 1 5 <210> 173 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC CDR2 <400> 173 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 174 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC CDR3 <400> 174 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 175 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 30 LC CDR1 <400> 175 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 176 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 30 LC CDR2 <400> 176 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 177 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 30 LC CDR3 <400> 177 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 178 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 30 HC CDR1 <400> 178 Ser Tyr Ala Ile Ser 1 5 <210> 179 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 30 HC CDR2 <400> 179 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 180 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 30 HC CDR3 <400> 180 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 181 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 31 LC CDR1 <400> 181 Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn Tyr Val His 1 5 10 <210> 182 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 31 LC CDR2 <400> 182 Ser Asn Asp Gln Arg Pro Ser 1 5 <210> 183 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 31 LC CDR3 <400> 183 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 184 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 31 HC CDR1 <400> 184 Ser Tyr Ala Ile Ser 1 5 <210> 185 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 31 HC CDR2 <400> 185 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 186 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 31 HC CDR3 <400> 186 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 187 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC CDR1 <400> 187 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 188 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC CDR2 <400> 188 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 189 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC CDR3 <400> 189 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 190 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC CDR1 <400> 190 Ser Tyr Ala Ile Ser 1 5 <210> 191 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC CDR2 <400> 191 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 192 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC CDR3 <400> 192 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 193 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC CDR1 <400> 193 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 194 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC CDR2 <400> 194 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 195 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC CDR3 <400> 195 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 196 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC CDR1 <400> 196 Ser Tyr Ala Ile Ser 1 5 <210> 197 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC CDR2 <400> 197 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 198 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC CDR3 <400> 198 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 199 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC CDR1 <400> 199 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 200 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC CDR2 <400> 200 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 201 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC CDR3 <400> 201 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 202 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC CDR1 <400> 202 Ser Tyr Ala Ile Ser 1 5 <210> 203 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC CDR2 <400> 203 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 204 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC CDR3 <400> 204 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 205 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC CDR1 <400> 205 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 206 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC CDR2 <400> 206 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 207 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC CDR3 <400> 207 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 208 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC CDR1 <400> 208 Ser Tyr Ala Ile Ser 1 5 <210> 209 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC CDR2 <400> 209 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 210 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC CDR3 <400> 210 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 211 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC CDR1 <400> 211 Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 212 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC CDR2 <400> 212 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 213 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC CDR3 <400> 213 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 214 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC CDR1 <400> 214 Ser Tyr Ala Ile Ser 1 5 <210> 215 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC CDR2 <400> 215 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 216 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC CDR3 <400> 216 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 217 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC CDR1 <400> 217 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 218 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC CDR2 <400> 218 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 219 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC CDR3 <400> 219 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 220 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC CDR1 <400> 220 Ser Tyr Ala Ile Ser 1 5 <210> 221 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC CDR2 <400> 221 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 222 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC CDR3 <400> 222 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 223 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC CDR1 <400> 223 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 224 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC CDR2 <400> 224 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 225 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC CDR3 <400> 225 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 226 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 38 HC CDR1 <400> 226 Ser Tyr Ala Ile Ser 1 5 <210> 227 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.38 HC CDR2 <400> 227 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 228 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.38 HC CDR3 <400> 228 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 229 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC CDR1 <400> 229 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 230 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC CDR2 <400> 230 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 231 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC CDR3 <400> 231 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 232 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC CDR1 <400> 232 Ser Tyr Ala Ile Ser 1 5 <210> 233 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC CDR2 <400> 233 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 234 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC CDR3 <400> 234 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 235 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 40 LC CDR1 <400> 235 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 236 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.40 LC CDR2 <400> 236 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 237 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.40 LC CDR3 <400> 237 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 238 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 40 HC CDR1 <400> 238 Ser Tyr Ala Ile Ser 1 5 <210> 239 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 40 HC CDR2 <400> 239 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 240 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No. 40 HC CDR3 <400> 240 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 241 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC CDR1 <400> 241 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 242 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC CDR2 <400> 242 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 243 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC CDR3 <400> 243 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 244 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC CDR1 <400> 244 Ser Tyr Ala Ile Ser 1 5 <210> 245 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC CDR2 <400> 245 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 246 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC CDR3 <400> 246 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 247 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC CDR1 <400> 247 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 248 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC CDR2 <400> 248 Arg Asn Asn Gln Arg Pro Ser 1 5 <210> 249 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC CDR3 <400> 249 Ala Ala Trp Asp Asp Ser Leu Ser Gly Lys Val 1 5 10 <210> 250 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC CDR1 <400> 250 Ser Tyr Ala Ile Ser 1 5 <210> 251 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC CDR2 <400> 251 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Asp <210> 252 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC CDR3 <400> 252 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 253 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC CDR1 <400> 253 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 1 5 10 <210> 254 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC CDR2 <400> 254 Arg Asn Asn Gln Arg Pro Pro 1 5 <210> 255 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC CDR3 <400> 255 Ala Ala Trp Asp Asp Ser Leu Ser Gly Arg Val 1 5 10 <210> 256 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC CDR1 <400> 256 Ser Tyr Ala Ile Ser 1 5 <210> 257 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC CDR2 <400> 257 Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 258 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC CDR3 <400> 258 Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp Pro Tyr 1 5 10 15 Tyr Tyr Gly Met Asp Val 20 <210> 259 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC CDR1 <400> 259 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 260 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC CDR2 <400> 260 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 261 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC CDR3 <400> 261 Gln Gln Tyr Val Thr Thr Pro Tyr Thr 1 5 <210> 262 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC CDR1 <400> 262 Arg Ser Ser Tyr Tyr Trp Gly 1 5 <210> 263 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC CDR2 <400> 263 Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 264 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC CDR3 <400> 264 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 265 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC CDR1 <400> 265 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 266 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC CDR2 <400> 266 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 267 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC CDR3 <400> 267 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 268 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC CDR1 <400> 268 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 269 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC CDR2 <400> 269 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 270 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC CDR3 <400> 270 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 271 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC CDR1 <400> 271 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 272 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC CDR2 <400> 272 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 273 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC CDR3 <400> 273 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 274 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC CDR1 <400> 274 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 275 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC CDR2 <400> 275 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 276 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC CDR3 <400> 276 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 277 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC CDR1 <400> 277 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 278 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC CDR2 <400> 278 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 279 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC CDR3 <400> 279 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 280 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC CDR1 <400> 280 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 281 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC CDR2 <400> 281 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 282 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC CDR3 <400> 282 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 283 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC CDR1 <400> 283 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 284 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC CDR2 <400> 284 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 285 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC CDR3 <400> 285 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 286 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC CDR1 <400> 286 His Tyr Phe Trp Ser 1 5 <210> 287 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC CDR2 <400> 287 Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 288 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC CDR3 <400> 288 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 289 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 49 LC CDR1 <400> 289 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 290 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 49 LC CDR2 <400> 290 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 291 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 49 LC CDR3 <400> 291 Ser Ser Tyr Thr Ser Ser Ser Thr Val Val 1 5 10 <210> 292 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 49 HC CDR1 <400> 292 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 293 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 49 HC CDR2 <400> 293 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 294 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 49 HC CDR3 <400> 294 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 295 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC CDR1 <400> 295 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 296 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC CDR2 <400> 296 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 297 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC CDR3 <400> 297 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 298 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC CDR1 <400> 298 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 299 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC CDR2 <400> 299 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 300 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC CDR3 <400> 300 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 301 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC CDR1 <400> 301 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 302 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC CDR2 <400> 302 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 303 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC CDR3 <400> 303 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 304 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC CDR1 <400> 304 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 305 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC CDR2 <400> 305 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 306 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC CDR3 <400> 306 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 307 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No. 52 LC CDR1 <400> 307 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 308 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.52 LC CDR2 <400> 308 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 309 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.52 LC CDR3 <400> 309 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 310 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 52 HC CDR1 <400> 310 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 311 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.52 HC CDR2 <400> 311 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 312 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.52 HC CDR3 <400> 312 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 313 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC CDR1 <400> 313 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 314 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC CDR2 <400> 314 Gly Gly Ser Ser Arg Ala Thr 1 5 <210> 315 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC CDR3 <400> 315 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 316 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC CDR1 <400> 316 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 317 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC CDR2 <400> 317 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 318 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC CDR3 <400> 318 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 319 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC CDR1 <400> 319 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 320 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC CDR2 <400> 320 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 321 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC CDR3 <400> 321 Ser Ser Tyr Thr Ser Ser Ser Thr His Val 1 5 10 <210> 322 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC CDR1 <400> 322 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 323 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC CDR2 <400> 323 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 324 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC CDR3 <400> 324 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 325 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC CDR1 <400> 325 Arg Ala Ser Gln Ser Val Ser Thr Tyr Leu Ala 1 5 10 <210> 326 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC CDR2 <400> 326 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 327 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC CDR3 <400> 327 Gln Gln Tyr Gly Ser Ser Pro Ser Ile Thr 1 5 10 <210> 328 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC CDR1 <400> 328 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 329 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC CDR2 <400> 329 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 330 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC CDR3 <400> 330 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 331 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC CDR1 <400> 331 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 332 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC CDR2 <400> 332 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 333 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC CDR3 <400> 333 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 334 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC CDR1 <400> 334 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 335 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC CDR2 <400> 335 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 336 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC CDR3 <400> 336 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 337 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.57 LC CDR1 <400> 337 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 338 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.57 LC CDR2 <400> 338 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 339 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 57 LC CDR3 <400> 339 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 340 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.57 HC CDR1 <400> 340 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 341 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.57 HC CDR2 <400> 341 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 342 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 57 HC CDR3 <400> 342 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 343 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.58 LC CDR1 <400> 343 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 344 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 58 LC CDR2 <400> 344 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 345 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.58 LC CDR3 <400> 345 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 346 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 58 HC CDR1 <400> 346 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 347 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 58 HC CDR2 <400> 347 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 348 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 58 HC CDR3 <400> 348 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 349 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC CDR1 <400> 349 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 350 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC CDR2 <400> 350 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 351 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC CDR3 <400> 351 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 352 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC CDR1 <400> 352 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 353 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC CDR2 <400> 353 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 354 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC CDR3 <400> 354 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 355 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC CDR1 <400> 355 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 356 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC CDR2 <400> 356 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 357 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC CDR3 <400> 357 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 358 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 60 HC CDR1 <400> 358 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 359 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.60 HC CDR2 <400> 359 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 360 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.60 HC CDR3 <400> 360 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 361 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC CDR1 <400> 361 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 362 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC CDR2 <400> 362 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 363 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC CDR3 <400> 363 Gln Gln Tyr Tyr Ser Thr Pro Ser Ile Thr 1 5 10 <210> 364 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC CDR1 <400> 364 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 365 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC CDR2 <400> 365 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 366 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC CDR3 <400> 366 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 367 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC CDR1 <400> 367 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 368 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC CDR2 <400> 368 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 369 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC CDR3 <400> 369 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 370 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC CDR1 <400> 370 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 371 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC CDR2 <400> 371 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 372 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC CDR3 <400> 372 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 373 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC CDR1 <400> 373 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 374 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC CDR2 <400> 374 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 375 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC CDR3 <400> 375 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 376 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC CDR1 <400> 376 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 377 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC CDR2 <400> 377 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 378 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC CDR3 <400> 378 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 379 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC CDR1 <400> 379 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 380 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC CDR2 <400> 380 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 381 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC CDR3 <400> 381 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 382 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC CDR1 <400> 382 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 383 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC CDR2 <400> 383 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 384 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC CDR3 <400> 384 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 385 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC CDR1 <400> 385 Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala 1 5 10 <210> 386 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC CDR2 <400> 386 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 387 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC CDR3 <400> 387 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 388 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC CDR1 <400> 388 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 389 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC CDR2 <400> 389 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 390 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC CDR3 <400> 390 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 391 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC CDR1 <400> 391 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 392 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC CDR2 <400> 392 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 393 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC CDR3 <400> 393 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 394 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC CDR1 <400> 394 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 395 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC CDR2 <400> 395 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 396 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC CDR3 <400> 396 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 397 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC CDR1 <400> 397 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 398 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC CDR2 <400> 398 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 399 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC CDR3 <400> 399 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 400 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC CDR1 <400> 400 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 401 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC CDR2 <400> 401 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 402 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC CDR3 <400> 402 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 403 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC CDR1 <400> 403 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 404 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC CDR2 <400> 404 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 405 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC CDR3 <400> 405 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 406 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC CDR1 <400> 406 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 407 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC CDR2 <400> 407 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 408 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC CDR3 <400> 408 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 409 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC CDR1 <400> 409 Arg Ala Ser Gln Ser Val Arg Ser Ser Tyr Leu Ala 1 5 10 <210> 410 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC CDR2 <400> 410 Ala Ala Ser Thr Arg Ala Thr 1 5 <210> 411 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC CDR3 <400> 411 Gln Gln Tyr Gly Asp Ser Leu Ser Ile Thr 1 5 10 <210> 412 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC CDR1 <400> 412 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 413 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC CDR2 <400> 413 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 414 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC CDR3 <400> 414 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 415 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.70 LC CDR1 <400> 415 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 416 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.70 LC CDR2 <400> 416 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 417 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No. 70 LC CDR3 <400> 417 Gln Gln Tyr Gly Ser Ser Pro Ser Ile Thr 1 5 10 <210> 418 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 70 HC CDR1 <400> 418 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 419 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 70 HC CDR2 <400> 419 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 420 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No. 70 HC CDR3 <400> 420 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 421 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC CDR1 <400> 421 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 422 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC CDR2 <400> 422 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 423 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC CDR3 <400> 423 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 424 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC CDR1 <400> 424 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 425 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC CDR2 <400> 425 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 426 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC CDR3 <400> 426 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 427 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC CDR1 <400> 427 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Ser 1 5 10 <210> 428 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC CDR2 <400> 428 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 429 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC CDR3 <400> 429 Ser Ser Tyr Thr Ser Ser Ser Thr Leu Pro 1 5 10 <210> 430 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC CDR1 <400> 430 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 431 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC CDR2 <400> 431 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 432 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC CDR3 <400> 432 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 433 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC CDR1 <400> 433 Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala 1 5 10 <210> 434 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC CDR2 <400> 434 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 435 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC CDR3 <400> 435 Gln Glu Tyr Gly Ser Ser Pro Gly Arg Val Thr 1 5 10 <210> 436 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC CDR1 <400> 436 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 437 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC CDR2 <400> 437 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 438 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC CDR3 <400> 438 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 439 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC CDR1 <400> 439 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 440 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC CDR2 <400> 440 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 441 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC CDR3 <400> 441 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 442 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC CDR1 <400> 442 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 443 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC CDR2 <400> 443 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 444 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC CDR3 <400> 444 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 445 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC CDR1 <400> 445 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 446 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC CDR2 <400> 446 Gly Ala Ser Ser Arg Ala Thr 1 5 <210> 447 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC CDR3 <400> 447 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 448 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC CDR1 <400> 448 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 449 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC CDR2 <400> 449 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 450 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC CDR3 <400> 450 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 451 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC CDR1 <400> 451 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 452 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC CDR2 <400> 452 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 453 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC CDR3 <400> 453 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 454 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC CDR1 <400> 454 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 455 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC CDR2 <400> 455 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 456 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC CDR3 <400> 456 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 457 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC CDR1 <400> 457 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 458 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC CDR2 <400> 458 Asp Ala Ser Thr Arg Ala Thr 1 5 <210> 459 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC CDR3 <400> 459 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 460 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC CDR1 <400> 460 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 461 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC CDR2 <400> 461 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 462 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC CDR3 <400> 462 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 463 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC CDR1 <400> 463 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 <210> 464 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC CDR2 <400> 464 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 465 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC CDR3 <400> 465 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 466 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC CDR1 <400> 466 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 467 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC CDR2 <400> 467 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 468 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC CDR3 <400> 468 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 469 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC CDR1 <400> 469 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 470 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC CDR2 <400> 470 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 471 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC CDR3 <400> 471 Gln Gln Tyr Tyr Ser Thr Pro Ser Ile Thr 1 5 10 <210> 472 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC CDR1 <400> 472 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 473 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC CDR2 <400> 473 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 474 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC CDR3 <400> 474 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 475 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC CDR1 <400> 475 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 476 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC CDR2 <400> 476 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 477 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC CDR3 <400> 477 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 478 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC CDR1 <400> 478 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 479 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC CDR2 <400> 479 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 480 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC CDR3 <400> 480 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 481 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC CDR1 <400> 481 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 482 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC CDR2 <400> 482 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 483 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC CDR3 <400> 483 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 484 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC CDR1 <400> 484 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 485 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC CDR2 <400> 485 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 486 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC CDR3 <400> 486 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 487 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC CDR1 <400> 487 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 488 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC CDR2 <400> 488 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 489 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC CDR3 <400> 489 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 490 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC CDR1 <400> 490 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 491 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC CDR2 <400> 491 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 492 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC CDR3 <400> 492 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 493 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC CDR1 <400> 493 Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 1 5 10 <210> 494 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC CDR2 <400> 494 Gly Ala Ser Thr Arg Ala Thr 1 5 <210> 495 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC CDR3 <400> 495 Gln Gln Tyr Asn Asn Trp Pro Leu Thr 1 5 <210> 496 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC CDR1 <400> 496 Gly Ser Ser Tyr Tyr Trp Gly 1 5 <210> 497 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC CDR2 <400> 497 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 498 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC CDR3 <400> 498 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 499 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC CDR1 <400> 499 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 1 5 10 <210> 500 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC CDR2 <400> 500 Asp Val Ser Asn Arg Pro Ser 1 5 <210> 501 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC CDR3 <400> 501 Ser Ser Tyr Thr Ser Ser Ser Thr Trp Val 1 5 10 <210> 502 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC CDR1 <400> 502 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 503 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC CDR2 <400> 503 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 504 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC CDR3 <400> 504 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 505 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC CDR1 <400> 505 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 1 5 10 <210> 506 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC CDR2 <400> 506 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 507 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC CDR3 <400> 507 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 508 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC CDR1 <400> 508 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 509 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC CDR2 <400> 509 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 510 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC CDR3 <400> 510 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 511 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC CDR1 <400> 511 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 512 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC CDR2 <400> 512 Asp Ala Ser Ser Arg Ala Thr 1 5 <210> 513 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC CDR3 <400> 513 Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 1 5 <210> 514 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC CDR1 <400> 514 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 515 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC CDR2 <400> 515 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 516 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC CDR3 <400> 516 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 517 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC CDR1 <400> 517 Arg Ala Ser Gln Ser Val Ser Asn Tyr Leu Ala 1 5 10 <210> 518 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC CDR2 <400> 518 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 519 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC CDR3 <400> 519 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 520 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC CDR1 <400> 520 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 521 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC CDR2 <400> 521 Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 522 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC CDR3 <400> 522 Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 523 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC CDR1 <400> 523 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 524 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC CDR2 <400> 524 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 525 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC CDR3 <400> 525 Gln Gln Tyr Gly Ser Ser Pro Ser Ile Thr 1 5 10 <210> 526 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC CDR1 <400> 526 Ser Ser Ser Tyr Tyr Trp Gly 1 5 <210> 527 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC CDR2 <400> 527 Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 <210> 528 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC CDR3 <400> 528 Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser Thr Gly Gly 1 5 10 15 Phe Asp Tyr <210> 529 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC CDR1 <400> 529 Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn Tyr Val Ser 1 5 10 <210> 530 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC CDR2 <400> 530 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 531 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC CDR3 <400> 531 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 532 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC CDR1 <400> 532 Thr Ser Gly Met Gly Val Gly 1 5 <210> 533 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC CDR2 <400> 533 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 534 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC CDR3 <400> 534 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 535 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC CDR1 <400> 535 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 536 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC CDR2 <400> 536 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 537 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC CDR3 <400> 537 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 538 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC CDR1 <400> 538 Thr Ser Gly Met Gly Val Gly 1 5 <210> 539 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC CDR2 <400> 539 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 540 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC CDR3 <400> 540 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 541 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC CDR1 <400> 541 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 542 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC CDR2 <400> 542 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 543 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC CDR3 <400> 543 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 544 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC CDR1 <400> 544 Thr Ser Gly Val Gly Val Gly 1 5 <210> 545 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC CDR2 <400> 545 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 546 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC CDR3 <400> 546 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 547 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC CDR1 <400> 547 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 548 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC CDR2 <400> 548 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 549 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC CDR3 <400> 549 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 550 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC CDR1 <400> 550 Thr Ser Gly Met Gly Val Gly 1 5 <210> 551 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC CDR2 <400> 551 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 552 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC CDR3 <400> 552 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 553 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC CDR1 <400> 553 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 554 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC CDR2 <400> 554 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 555 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC CDR3 <400> 555 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Arg 1 5 10 <210> 556 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC CDR1 <400> 556 Thr Ser Gly Val Gly Val Gly 1 5 <210> 557 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC CDR2 <400> 557 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 558 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC CDR3 <400> 558 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 559 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC CDR1 <400> 559 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 560 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC CDR2 <400> 560 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 561 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC CDR3 <400> 561 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 562 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC CDR1 <400> 562 Thr Ser Gly Met Gly Val Gly 1 5 <210> 563 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC CDR2 <400> 563 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 564 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC CDR3 <400> 564 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 565 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC CDR1 <400> 565 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 566 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC CDR2 <400> 566 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 567 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC CDR3 <400> 567 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 568 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC CDR1 <400> 568 Thr Ser Gly Val Gly Val Gly 1 5 <210> 569 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC CDR2 <400> 569 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 570 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC CDR3 <400> 570 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 571 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 96 LC CDR1 <400> 571 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 572 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 96 LC CDR2 <400> 572 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 573 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 96 LC CDR3 <400> 573 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 574 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 96 HC CDR1 <400> 574 Thr Ser Gly Met Gly Val Gly 1 5 <210> 575 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 96 HC CDR2 <400> 575 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 576 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 96 HC CDR3 <400> 576 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 577 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC CDR1 <400> 577 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 578 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC CDR2 <400> 578 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 579 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC CDR3 <400> 579 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 580 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC CDR1 <400> 580 Thr Ser Gly Met Gly Val Ser 1 5 <210> 581 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC CDR2 <400> 581 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 582 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC CDR3 <400> 582 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 583 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 98 LC CDR1 <400> 583 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 584 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.98 LC CDR2 <400> 584 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 585 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 98 LC CDR3 <400> 585 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 586 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 98 HC CDR1 <400> 586 Thr Ser Gly Met Gly Val Gly 1 5 <210> 587 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 98 HC CDR2 <400> 587 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 588 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 98 HC CDR3 <400> 588 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 589 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC CDR1 <400> 589 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 590 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC CDR2 <400> 590 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 591 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC CDR3 <400> 591 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 592 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC CDR1 <400> 592 Thr Ser Gly Met Gly Val Gly 1 5 <210> 593 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC CDR2 <400> 593 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 594 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC CDR3 <400> 594 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 595 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC CDR1 <400> 595 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 596 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC CDR2 <400> 596 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 597 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC CDR3 <400> 597 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 598 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 100 HC CDR1 <400> 598 Thr Ser Gly Met Gly Val Gly 1 5 <210> 599 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 100 HC CDR2 <400> 599 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 600 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.100 HC CDR3 <400> 600 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 601 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 101 LC CDR1 <400> 601 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 602 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 101 LC CDR2 <400> 602 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 603 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 101 LC CDR3 <400> 603 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 604 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 101 HC CDR1 <400> 604 Thr Ser Gly Met Gly Val Gly 1 5 <210> 605 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 101 HC CDR2 <400> 605 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 606 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 101 HC CDR3 <400> 606 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 607 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC CDR1 <400> 607 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 608 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC CDR2 <400> 608 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 609 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC CDR3 <400> 609 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 610 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC CDR1 <400> 610 Thr Ser Gly Met Gly Val Gly 1 5 <210> 611 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC CDR2 <400> 611 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 612 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC CDR3 <400> 612 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 613 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC CDR1 <400> 613 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 614 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC CDR2 <400> 614 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 615 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC CDR3 <400> 615 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 616 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC CDR1 <400> 616 Thr Ser Gly Val Gly Val Gly 1 5 <210> 617 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC CDR2 <400> 617 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 618 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC CDR3 <400> 618 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 619 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC CDR1 <400> 619 Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 620 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC CDR2 <400> 620 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 621 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC CDR3 <400> 621 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 622 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC CDR1 <400> 622 Thr Ser Gly Val Gly Val Gly 1 5 <210> 623 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC CDR2 <400> 623 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 624 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC CDR3 <400> 624 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 625 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC CDR1 <400> 625 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 626 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC CDR2 <400> 626 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 627 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC CDR3 <400> 627 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 628 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC CDR1 <400> 628 Thr Ser Gly Val Gly Val Gly 1 5 <210> 629 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC CDR2 <400> 629 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 630 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC CDR3 <400> 630 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 631 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC CDR1 <400> 631 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 632 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC CDR2 <400> 632 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 633 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC CDR3 <400> 633 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 634 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC CDR1 <400> 634 Thr Ser Gly Met Gly Val Gly 1 5 <210> 635 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC CDR2 <400> 635 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 636 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC CDR3 <400> 636 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 637 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC CDR1 <400> 637 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 638 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC CDR2 <400> 638 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 639 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC CDR3 <400> 639 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 640 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC CDR1 <400> 640 Thr Ser Gly Met Gly Val Gly 1 5 <210> 641 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC CDR2 <400> 641 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 642 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC CDR3 <400> 642 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 643 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC CDR1 <400> 643 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 644 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC CDR2 <400> 644 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 645 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC CDR3 <400> 645 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 646 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC CDR1 <400> 646 Thr Ser Gly Met Gly Val Gly 1 5 <210> 647 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC CDR2 <400> 647 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 648 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC CDR3 <400> 648 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 649 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC CDR1 <400> 649 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 650 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC CDR2 <400> 650 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 651 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC CDR3 <400> 651 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 652 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC CDR1 <400> 652 Thr Ser Gly Met Gly Val Gly 1 5 <210> 653 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC CDR2 <400> 653 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 654 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC CDR3 <400> 654 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 655 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC CDR1 <400> 655 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 656 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC CDR2 <400> 656 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 657 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 110 LC CDR3 <400> 657 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 658 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 110 HC CDR1 <400> 658 Thr Ser Gly Met Gly Val Gly 1 5 <210> 659 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 110 HC CDR2 <400> 659 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 660 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 110 HC CDR3 <400> 660 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 661 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC CDR1 <400> 661 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 662 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC CDR2 <400> 662 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 663 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC CDR3 <400> 663 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 664 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC CDR1 <400> 664 Thr Ser Gly Met Gly Val Gly 1 5 <210> 665 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC CDR2 <400> 665 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 666 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC CDR3 <400> 666 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 667 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC CDR1 <400> 667 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 668 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC CDR2 <400> 668 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 669 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC CDR3 <400> 669 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 670 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC CDR1 <400> 670 Thr Ser Gly Val Gly Val Gly 1 5 <210> 671 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC CDR2 <400> 671 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 672 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC CDR3 <400> 672 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 673 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC CDR1 <400> 673 Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn Tyr Ile Ser 1 5 10 <210> 674 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC CDR2 <400> 674 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 675 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC CDR3 <400> 675 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 676 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC CDR1 <400> 676 Thr Ser Gly Val Gly Val Gly 1 5 <210> 677 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC CDR2 <400> 677 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 678 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC CDR3 <400> 678 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 679 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC CDR1 <400> 679 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 680 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC CDR2 <400> 680 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 681 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC CDR3 <400> 681 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 682 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC CDR1 <400> 682 Thr Ser Gly Met Gly Val Gly 1 5 <210> 683 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC CDR2 <400> 683 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 684 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC CDR3 <400> 684 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 685 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC CDR1 <400> 685 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 686 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC CDR2 <400> 686 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 687 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC CDR3 <400> 687 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 688 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC CDR1 <400> 688 Thr Ser Gly Met Gly Val Gly 1 5 <210> 689 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC CDR2 <400> 689 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 690 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC CDR3 <400> 690 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 691 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC CDR1 <400> 691 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 692 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC CDR2 <400> 692 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 693 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC CDR3 <400> 693 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 694 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC CDR1 <400> 694 Thr Ser Gly Met Gly Val Gly 1 5 <210> 695 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC CDR2 <400> 695 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 696 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC CDR3 <400> 696 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 697 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC CDR1 <400> 697 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 698 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC CDR2 <400> 698 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 699 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC CDR3 <400> 699 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 700 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC CDR1 <400> 700 Thr Ser Gly Met Gly Val Gly 1 5 <210> 701 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC CDR2 <400> 701 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 702 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC CDR3 <400> 702 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 703 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC CDR1 <400> 703 Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 704 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC CDR2 <400> 704 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 705 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC CDR3 <400> 705 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 706 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC CDR1 <400> 706 Thr Ser Gly Met Gly Val Gly 1 5 <210> 707 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC CDR2 <400> 707 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 708 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC CDR3 <400> 708 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 709 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC CDR1 <400> 709 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 710 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC CDR2 <400> 710 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 711 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC CDR3 <400> 711 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 712 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC CDR1 <400> 712 Thr Ser Gly Met Gly Val Gly 1 5 <210> 713 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC CDR2 <400> 713 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 714 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC CDR3 <400> 714 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 715 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 120 LC CDR1 <400> 715 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 716 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.120 LC CDR2 <400> 716 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 717 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.120 LC CDR3 <400> 717 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 718 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 120 HC CDR1 <400> 718 Thr Ser Gly Val Gly Val Gly 1 5 <210> 719 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 120 HC CDR2 <400> 719 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 720 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 120 HC CDR3 <400> 720 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 721 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC CDR1 <400> 721 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 722 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC CDR2 <400> 722 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 723 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC CDR3 <400> 723 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 724 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC CDR1 <400> 724 Thr Ser Gly Met Gly Val Gly 1 5 <210> 725 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC CDR2 <400> 725 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 726 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC CDR3 <400> 726 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 727 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC CDR1 <400> 727 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 728 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC CDR2 <400> 728 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 729 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC CDR3 <400> 729 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 730 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC CDR1 <400> 730 Thr Ser Gly Met Gly Val Gly 1 5 <210> 731 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC CDR2 <400> 731 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 732 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC CDR3 <400> 732 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 733 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC CDR1 <400> 733 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 734 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC CDR2 <400> 734 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 735 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC CDR3 <400> 735 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 736 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC CDR1 <400> 736 Thr Ser Gly Met Gly Val Gly 1 5 <210> 737 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC CDR2 <400> 737 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 738 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC CDR3 <400> 738 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 739 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC CDR1 <400> 739 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 740 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC CDR2 <400> 740 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 741 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC CDR3 <400> 741 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 742 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC CDR1 <400> 742 Thr Ser Gly Val Gly Val Gly 1 5 <210> 743 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC CDR2 <400> 743 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 744 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC CDR3 <400> 744 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 745 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC CDR1 <400> 745 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 746 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC CDR2 <400> 746 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 747 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC CDR3 <400> 747 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 748 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC CDR1 <400> 748 Thr Ser Gly Met Gly Val Gly 1 5 <210> 749 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC CDR2 <400> 749 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 750 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC CDR3 <400> 750 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 751 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC CDR1 <400> 751 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 752 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC CDR2 <400> 752 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 753 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC CDR3 <400> 753 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 754 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC CDR1 <400> 754 Thr Ser Gly Met Gly Val Gly 1 5 <210> 755 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC CDR2 <400> 755 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 756 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC CDR3 <400> 756 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 757 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC CDR1 <400> 757 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 758 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC CDR2 <400> 758 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 759 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC CDR3 <400> 759 Gly Thr Trp Asp Asn Ser Leu Ser Ala Gly Val 1 5 10 <210> 760 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC CDR1 <400> 760 Thr Ser Gly Val Gly Val Gly 1 5 <210> 761 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC CDR2 <400> 761 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 762 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC CDR3 <400> 762 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 763 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC CDR1 <400> 763 Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Phe Val Ser 1 5 10 <210> 764 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC CDR2 <400> 764 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 765 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC CDR3 <400> 765 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 766 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 128 HC CDR1 <400> 766 Thr Ser Gly Val Gly Val Gly 1 5 <210> 767 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.128 HC CDR2 <400> 767 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 768 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 128 HC CDR3 <400> 768 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 769 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC CDR1 <400> 769 Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 770 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC CDR2 <400> 770 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 771 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC CDR3 <400> 771 Gly Thr Trp Asp Asn Asn Leu Ser Ala Gly Val 1 5 10 <210> 772 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC CDR1 <400> 772 Thr Ser Gly Val Gly Val Gly 1 5 <210> 773 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC CDR2 <400> 773 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 774 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC CDR3 <400> 774 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 775 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.130 LC CDR1 <400> 775 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 776 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.130 LC CDR2 <400> 776 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 777 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 130 LC CDR3 <400> 777 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 778 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 130 HC CDR1 <400> 778 Thr Ser Gly Met Gly Val Gly 1 5 <210> 779 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 130 HC CDR2 <400> 779 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 780 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 130 HC CDR3 <400> 780 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 781 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC CDR1 <400> 781 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 782 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC CDR2 <400> 782 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 783 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC CDR3 <400> 783 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 784 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC CDR1 <400> 784 Thr Ser Gly Val Gly Val Gly 1 5 <210> 785 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC CDR2 <400> 785 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 786 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC CDR3 <400> 786 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 787 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC CDR1 <400> 787 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 788 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC CDR2 <400> 788 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 789 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC CDR3 <400> 789 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 790 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC CDR1 <400> 790 Thr Ser Gly Met Gly Val Gly 1 5 <210> 791 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC CDR2 <400> 791 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 792 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC CDR3 <400> 792 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 793 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC CDR1 <400> 793 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 794 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC CDR2 <400> 794 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 795 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC CDR3 <400> 795 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 796 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC CDR1 <400> 796 Thr Ser Gly Met Gly Val Gly 1 5 <210> 797 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC CDR2 <400> 797 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 798 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC CDR3 <400> 798 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 799 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC CDR1 <400> 799 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 800 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC CDR2 <400> 800 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 801 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC CDR3 <400> 801 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 802 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC CDR1 <400> 802 Thr Ser Gly Met Gly Val Gly 1 5 <210> 803 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC CDR2 <400> 803 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 804 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC CDR3 <400> 804 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 805 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC CDR1 <400> 805 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 806 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC CDR2 <400> 806 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 807 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC CDR3 <400> 807 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 808 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC CDR1 <400> 808 Thr Ser Gly Met Gly Val Gly 1 5 <210> 809 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC CDR2 <400> 809 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 810 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC CDR3 <400> 810 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 811 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC CDR1 <400> 811 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 812 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC CDR2 <400> 812 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 813 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC CDR3 <400> 813 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 814 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC CDR1 <400> 814 Thr Ser Gly Met Gly Val Gly 1 5 <210> 815 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC CDR2 <400> 815 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 816 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC CDR3 <400> 816 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 817 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC CDR1 <400> 817 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 818 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC CDR2 <400> 818 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 819 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC CDR3 <400> 819 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 820 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC CDR1 <400> 820 Thr Ser Gly Val Gly Val Gly 1 5 <210> 821 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC CDR2 <400> 821 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 822 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC CDR3 <400> 822 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 823 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC CDR1 <400> 823 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 824 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC CDR2 <400> 824 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 825 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC CDR3 <400> 825 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 826 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC CDR1 <400> 826 Thr Ser Gly Val Gly Val Gly 1 5 <210> 827 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC CDR2 <400> 827 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 828 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC CDR3 <400> 828 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 829 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC CDR1 <400> 829 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 830 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC CDR2 <400> 830 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 831 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC CDR3 <400> 831 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 832 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC CDR1 <400> 832 Thr Ser Gly Val Gly Val Gly 1 5 <210> 833 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC CDR2 <400> 833 Leu Ile Asp Trp Asp Asp Asn Lys Tyr His Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 834 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC CDR3 <400> 834 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 835 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 140 LC CDR1 <400> 835 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 836 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 140 LC CDR2 <400> 836 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 837 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 140 LC CDR3 <400> 837 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 838 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 140 HC CDR1 <400> 838 Thr Ser Gly Met Gly Val Ser 1 5 <210> 839 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 140 HC CDR2 <400> 839 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 840 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 140 HC CDR3 <400> 840 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 841 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC CDR1 <400> 841 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 842 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC CDR2 <400> 842 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 843 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC CDR3 <400> 843 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 844 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC CDR1 <400> 844 Thr Ser Gly Met Gly Val Gly 1 5 <210> 845 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC CDR2 <400> 845 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 846 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC CDR3 <400> 846 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 847 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC CDR1 <400> 847 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 848 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC CDR2 <400> 848 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 849 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC CDR3 <400> 849 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 850 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC CDR1 <400> 850 Thr Ser Gly Met Gly Val Gly 1 5 <210> 851 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC CDR2 <400> 851 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 852 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC CDR3 <400> 852 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 853 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC CDR1 <400> 853 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 854 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC CDR2 <400> 854 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 855 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC CDR3 <400> 855 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 856 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC CDR1 <400> 856 Thr Ser Gly Val Gly Val Gly 1 5 <210> 857 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC CDR2 <400> 857 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 858 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC CDR3 <400> 858 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 859 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC CDR1 <400> 859 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 860 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC CDR2 <400> 860 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 861 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC CDR3 <400> 861 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 862 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC CDR1 <400> 862 Thr Ser Gly Met Gly Val Gly 1 5 <210> 863 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC CDR2 <400> 863 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 864 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC CDR3 <400> 864 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 865 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC CDR1 <400> 865 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 866 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC CDR2 <400> 866 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 867 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC CDR3 <400> 867 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 868 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC CDR1 <400> 868 Thr Ser Gly Val Gly Val Gly 1 5 <210> 869 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC CDR2 <400> 869 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 870 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC CDR3 <400> 870 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 871 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC CDR1 <400> 871 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 872 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC CDR2 <400> 872 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 873 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC CDR3 <400> 873 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 874 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC CDR1 <400> 874 Thr Ser Gly Met Gly Val Gly 1 5 <210> 875 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC CDR2 <400> 875 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 876 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC CDR3 <400> 876 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 877 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC CDR1 <400> 877 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 878 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC CDR2 <400> 878 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 879 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC CDR3 <400> 879 Gly Thr Trp Asp Ser Ser Leu Ser Gly Gly Val 1 5 10 <210> 880 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC CDR1 <400> 880 Thr Ser Gly Met Gly Val Gly 1 5 <210> 881 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC CDR2 <400> 881 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 882 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC CDR3 <400> 882 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 883 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC CDR1 <400> 883 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 884 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC CDR2 <400> 884 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 885 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC CDR3 <400> 885 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 886 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC CDR1 <400> 886 Thr Ser Gly Met Gly Val Gly 1 5 <210> 887 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC CDR2 <400> 887 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 888 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC CDR3 <400> 888 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 889 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC CDR1 <400> 889 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 890 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC CDR2 <400> 890 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 891 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC CDR3 <400> 891 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 892 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC CDR1 <400> 892 Thr Ser Gly Met Gly Val Gly 1 5 <210> 893 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC CDR2 <400> 893 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 894 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC CDR3 <400> 894 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 895 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC CDR1 <400> 895 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 896 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC CDR2 <400> 896 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 897 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC CDR3 <400> 897 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 898 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC CDR1 <400> 898 Thr Ser Gly Met Gly Val Gly 1 5 <210> 899 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC CDR2 <400> 899 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 900 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC CDR3 <400> 900 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 901 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC CDR1 <400> 901 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 902 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC CDR2 <400> 902 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 903 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC CDR3 <400> 903 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 904 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC CDR1 <400> 904 Thr Ser Gly Val Gly Val Gly 1 5 <210> 905 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC CDR2 <400> 905 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 906 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC CDR3 <400> 906 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 907 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC CDR1 <400> 907 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 908 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC CDR2 <400> 908 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 909 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC CDR3 <400> 909 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 910 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC CDR1 <400> 910 Thr Ser Gly Met Gly Val Gly 1 5 <210> 911 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC CDR2 <400> 911 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 912 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC CDR3 <400> 912 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 913 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC CDR1 <400> 913 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 914 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC CDR2 <400> 914 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 915 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC CDR3 <400> 915 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 916 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC CDR1 <400> 916 Thr Ser Gly Val Gly Val Gly 1 5 <210> 917 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC CDR2 <400> 917 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 918 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC CDR3 <400> 918 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 919 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC CDR1 <400> 919 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 920 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC CDR2 <400> 920 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 921 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC CDR3 <400> 921 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 922 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC CDR1 <400> 922 Thr Ser Gly Val Gly Val Gly 1 5 <210> 923 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC CDR2 <400> 923 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 924 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC CDR3 <400> 924 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 925 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC CDR1 <400> 925 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 926 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC CDR2 <400> 926 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 927 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC CDR3 <400> 927 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 928 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC CDR1 <400> 928 Thr Ser Gly Met Gly Val Gly 1 5 <210> 929 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC CDR2 <400> 929 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 930 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC CDR3 <400> 930 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 931 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC CDR1 <400> 931 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 932 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC CDR2 <400> 932 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 933 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC CDR3 <400> 933 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 934 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC CDR1 <400> 934 Thr Ser Gly Met Gly Val Gly 1 5 <210> 935 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC CDR2 <400> 935 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 936 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC CDR3 <400> 936 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 937 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC CDR1 <400> 937 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 938 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC CDR2 <400> 938 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 939 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC CDR3 <400> 939 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 940 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC CDR1 <400> 940 Thr Ser Gly Val Gly Val Gly 1 5 <210> 941 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC CDR2 <400> 941 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 942 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC CDR3 <400> 942 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 943 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC CDR1 <400> 943 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 944 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC CDR2 <400> 944 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 945 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC CDR3 <400> 945 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 946 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC CDR1 <400> 946 Thr Ser Gly Val Gly Val Gly 1 5 <210> 947 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC CDR2 <400> 947 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 948 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC CDR3 <400> 948 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 949 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC CDR1 <400> 949 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 950 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC CDR2 <400> 950 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 951 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC CDR3 <400> 951 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 952 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC CDR1 <400> 952 Thr Ser Gly Val Gly Val Gly 1 5 <210> 953 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC CDR2 <400> 953 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 954 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC CDR3 <400> 954 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 955 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 160 LC CDR1 <400> 955 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 956 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 160 LC CDR2 <400> 956 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 957 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 160 LC CDR3 <400> 957 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 958 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 160 HC CDR1 <400> 958 Thr Ser Gly Val Gly Val Gly 1 5 <210> 959 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 160 HC CDR2 <400> 959 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 960 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 160 HC CDR3 <400> 960 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 961 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC CDR1 <400> 961 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 962 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC CDR2 <400> 962 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 963 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC CDR3 <400> 963 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 964 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC CDR1 <400> 964 Thr Ser Gly Met Gly Val Gly 1 5 <210> 965 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC CDR2 <400> 965 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 966 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC CDR3 <400> 966 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 967 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC CDR1 <400> 967 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 968 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC CDR2 <400> 968 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 969 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC CDR3 <400> 969 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 970 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC CDR1 <400> 970 Thr Ser Gly Val Gly Val Gly 1 5 <210> 971 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC CDR2 <400> 971 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 972 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC CDR3 <400> 972 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 973 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC CDR1 <400> 973 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 974 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC CDR2 <400> 974 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 975 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC CDR3 <400> 975 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 976 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC CDR1 <400> 976 Thr Ser Gly Met Gly Val Gly 1 5 <210> 977 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC CDR2 <400> 977 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 978 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC CDR3 <400> 978 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 979 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC CDR1 <400> 979 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 980 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC CDR2 <400> 980 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 981 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC CDR3 <400> 981 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 982 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC CDR1 <400> 982 Thr Ser Gly Val Gly Val Gly 1 5 <210> 983 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC CDR2 <400> 983 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 984 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC CDR3 <400> 984 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 985 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC CDR1 <400> 985 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 986 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC CDR2 <400> 986 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 987 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC CDR3 <400> 987 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 988 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC CDR1 <400> 988 Thr Ser Gly Met Gly Val Gly 1 5 <210> 989 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC CDR2 <400> 989 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 990 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC CDR3 <400> 990 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 991 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC CDR1 <400> 991 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 992 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC CDR2 <400> 992 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 993 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC CDR3 <400> 993 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 994 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC CDR1 <400> 994 Thr Ser Gly Met Gly Val Gly 1 5 <210> 995 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC CDR2 <400> 995 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 996 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC CDR3 <400> 996 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 997 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC CDR1 <400> 997 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 998 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC CDR2 <400> 998 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 999 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC CDR3 <400> 999 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1000 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC CDR1 <400> 1000 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1001 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC CDR2 <400> 1001 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1002 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC CDR3 <400> 1002 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1003 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC CDR1 <400> 1003 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1004 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC CDR2 <400> 1004 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1005 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC CDR3 <400> 1005 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1006 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC CDR1 <400> 1006 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1007 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC CDR2 <400> 1007 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1008 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC CDR3 <400> 1008 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1009 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC CDR1 <400> 1009 Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn Tyr Val Ser 1 5 10 <210> 1010 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC CDR2 <400> 1010 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1011 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC CDR3 <400> 1011 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1012 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC CDR1 <400> 1012 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1013 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC CDR2 <400> 1013 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1014 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC CDR3 <400> 1014 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1015 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC CDR1 <400> 1015 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1016 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC CDR2 <400> 1016 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1017 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC CDR3 <400> 1017 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1018 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC CDR1 <400> 1018 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1019 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC CDR2 <400> 1019 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1020 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC CDR3 <400> 1020 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1021 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC CDR1 <400> 1021 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1022 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC CDR2 <400> 1022 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1023 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC CDR3 <400> 1023 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1024 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC CDR1 <400> 1024 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1025 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC CDR2 <400> 1025 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1026 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC CDR3 <400> 1026 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1027 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.172 LC CDR1 <400> 1027 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1028 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 172 LC CDR2 <400> 1028 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1029 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.172 LC CDR3 <400> 1029 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1030 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC CDR1 <400> 1030 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1031 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC CDR2 <400> 1031 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1032 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC CDR3 <400> 1032 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1033 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC CDR1 <400> 1033 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1034 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC CDR2 <400> 1034 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1035 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC CDR3 <400> 1035 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1036 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC CDR1 <400> 1036 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1037 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC CDR2 <400> 1037 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1038 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC CDR3 <400> 1038 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1039 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC CDR1 <400> 1039 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1040 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC CDR2 <400> 1040 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1041 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC CDR3 <400> 1041 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1042 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC CDR1 <400> 1042 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1043 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC CDR2 <400> 1043 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1044 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC CDR3 <400> 1044 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1045 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC CDR1 <400> 1045 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1046 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC CDR2 <400> 1046 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1047 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC CDR3 <400> 1047 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1048 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC CDR1 <400> 1048 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1049 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC CDR2 <400> 1049 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1050 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC CDR3 <400> 1050 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1051 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC CDR1 <400> 1051 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1052 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC CDR2 <400> 1052 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1053 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC CDR3 <400> 1053 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1054 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC CDR1 <400> 1054 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1055 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC CDR2 <400> 1055 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1056 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC CDR3 <400> 1056 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1057 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC CDR1 <400> 1057 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1058 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC CDR2 <400> 1058 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1059 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC CDR3 <400> 1059 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1060 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC CDR1 <400> 1060 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1061 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC CDR2 <400> 1061 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1062 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC CDR3 <400> 1062 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1063 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC CDR1 <400> 1063 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1064 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC CDR2 <400> 1064 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1065 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC CDR3 <400> 1065 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1066 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC CDR1 <400> 1066 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1067 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC CDR2 <400> 1067 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1068 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC CDR3 <400> 1068 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1069 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC CDR1 <400> 1069 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1070 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC CDR2 <400> 1070 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1071 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC CDR3 <400> 1071 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1072 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC CDR1 <400> 1072 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1073 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC CDR2 <400> 1073 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1074 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC CDR3 <400> 1074 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1075 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC CDR1 <400> 1075 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1076 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC CDR2 <400> 1076 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1077 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC CDR3 <400> 1077 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1078 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC CDR1 <400> 1078 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1079 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC CDR2 <400> 1079 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1080 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC CDR3 <400> 1080 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1081 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC CDR1 <400> 1081 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1082 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC CDR2 <400> 1082 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1083 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC CDR3 <400> 1083 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1084 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC CDR1 <400> 1084 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1085 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC CDR2 <400> 1085 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1086 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC CDR3 <400> 1086 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1087 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC CDR1 <400> 1087 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1088 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC CDR2 <400> 1088 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1089 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC CDR3 <400> 1089 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1090 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC CDR1 <400> 1090 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1091 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC CDR2 <400> 1091 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1092 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC CDR3 <400> 1092 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1093 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC CDR1 <400> 1093 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1094 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC CDR2 <400> 1094 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1095 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC CDR3 <400> 1095 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1096 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC CDR1 <400> 1096 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1097 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC CDR2 <400> 1097 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1098 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC CDR3 <400> 1098 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1099 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC CDR1 <400> 1099 Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn Tyr Val Ser 1 5 10 <210> 1100 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC CDR2 <400> 1100 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 1101 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC CDR3 <400> 1101 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1102 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC CDR1 <400> 1102 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1103 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC CDR2 <400> 1103 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1104 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC CDR3 <400> 1104 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1105 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC CDR1 <400> 1105 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1106 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC CDR2 <400> 1106 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1107 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC CDR3 <400> 1107 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1108 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC CDR1 <400> 1108 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1109 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC CDR2 <400> 1109 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1110 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC CDR3 <400> 1110 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1111 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC CDR1 <400> 1111 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1112 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC CDR2 <400> 1112 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1113 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC CDR3 <400> 1113 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1114 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC CDR1 <400> 1114 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1115 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC CDR2 <400> 1115 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1116 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC CDR3 <400> 1116 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1117 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC CDR1 <400> 1117 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1118 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC CDR2 <400> 1118 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1119 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC CDR3 <400> 1119 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1120 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC CDR1 <400> 1120 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1121 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC CDR2 <400> 1121 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1122 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC CDR3 <400> 1122 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1123 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC CDR1 <400> 1123 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1124 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC CDR2 <400> 1124 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1125 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC CDR3 <400> 1125 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1126 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC CDR1 <400> 1126 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1127 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC CDR2 <400> 1127 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1128 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC CDR3 <400> 1128 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1129 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC CDR1 <400> 1129 Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1130 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC CDR2 <400> 1130 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1131 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC CDR3 <400> 1131 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1132 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC CDR1 <400> 1132 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1133 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC CDR2 <400> 1133 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1134 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC CDR3 <400> 1134 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1135 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC CDR1 <400> 1135 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1136 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC CDR2 <400> 1136 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1137 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC CDR3 <400> 1137 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1138 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC CDR1 <400> 1138 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1139 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC CDR2 <400> 1139 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1140 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC CDR3 <400> 1140 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1141 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 191 LC CDR1 <400> 1141 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1142 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 191 LC CDR2 <400> 1142 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1143 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 191 LC CDR3 <400> 1143 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1144 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 191 HC CDR1 <400> 1144 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1145 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No. 191 HC CDR2 <400> 1145 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1146 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 191 HC CDR3 <400> 1146 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1147 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC CDR1 <400> 1147 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1148 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC CDR2 <400> 1148 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1149 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC CDR3 <400> 1149 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1150 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC CDR1 <400> 1150 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1151 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC CDR2 <400> 1151 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1152 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC CDR3 <400> 1152 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1153 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC CDR1 <400> 1153 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1154 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC CDR2 <400> 1154 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1155 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC CDR3 <400> 1155 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1156 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC CDR1 <400> 1156 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1157 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC CDR2 <400> 1157 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1158 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC CDR3 <400> 1158 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1159 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC CDR1 <400> 1159 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1160 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC CDR2 <400> 1160 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1161 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC CDR3 <400> 1161 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1162 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC CDR1 <400> 1162 Thr Ser Gly Met Gly Val Gly 1 5 <210> 1163 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC CDR2 <400> 1163 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1164 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC CDR3 <400> 1164 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1165 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC CDR1 <400> 1165 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 1166 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC CDR2 <400> 1166 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 1167 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC CDR3 <400> 1167 Gln Ser Tyr Asp Ser Ser Asp Trp Val 1 5 <210> 1168 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC CDR1 <400> 1168 Arg Tyr Gly Ile Ser 1 5 <210> 1169 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC CDR2 <400> 1169 Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu Gln 1 5 10 15 Gly <210> 1170 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC CDR3 <400> 1170 Val Leu Gly Ile Ala Val Ala Gly Thr Pro Ile 1 5 10 <210> 1171 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC CDR1 <400> 1171 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1172 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC CDR2 <400> 1172 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1173 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC CDR3 <400> 1173 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1174 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC CDR1 <400> 1174 Ser Tyr Ala Ile Ser 1 5 <210> 1175 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC CDR2 <400> 1175 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1176 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC CDR3 <400> 1176 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1177 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC CDR1 <400> 1177 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1178 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC CDR2 <400> 1178 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1179 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC CDR3 <400> 1179 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Ile 1 5 10 <210> 1180 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC CDR1 <400> 1180 Ser Tyr Ala Ile Ser 1 5 <210> 1181 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC CDR2 <400> 1181 Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1182 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC CDR3 <400> 1182 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1183 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC CDR1 <400> 1183 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1184 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC CDR2 <400> 1184 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1185 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC CDR3 <400> 1185 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1186 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC CDR1 <400> 1186 Ser Tyr Ala Ile Ser 1 5 <210> 1187 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC CDR2 <400> 1187 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1188 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC CDR3 <400> 1188 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1189 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC CDR1 <400> 1189 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1190 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC CDR2 <400> 1190 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1191 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC CDR3 <400> 1191 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Ile 1 5 10 <210> 1192 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC CDR1 <400> 1192 Ser Tyr Ala Ile Ser 1 5 <210> 1193 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC CDR2 <400> 1193 Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1194 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC CDR3 <400> 1194 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1195 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC CDR1 <400> 1195 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1196 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC CDR2 <400> 1196 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1197 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC CDR3 <400> 1197 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1198 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC CDR1 <400> 1198 Ser Tyr Ala Ile Ser 1 5 <210> 1199 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC CDR2 <400> 1199 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1200 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC CDR3 <400> 1200 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp Tyr 1 5 10 15 <210> 1201 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC CDR1 <400> 1201 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1202 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC CDR2 <400> 1202 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1203 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC CDR3 <400> 1203 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1204 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC CDR1 <400> 1204 Ser Tyr Ala Ile Ser 1 5 <210> 1205 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC CDR2 <400> 1205 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1206 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC CDR3 <400> 1206 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp Tyr 1 5 10 15 <210> 1207 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC CDR1 <400> 1207 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1208 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC CDR2 <400> 1208 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1209 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC CDR3 <400> 1209 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1210 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC CDR1 <400> 1210 Ser Tyr Ala Ile Ser 1 5 <210> 1211 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC CDR2 <400> 1211 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1212 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC CDR3 <400> 1212 Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp Tyr 1 5 10 15 <210> 1213 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC CDR1 <400> 1213 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1214 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC CDR2 <400> 1214 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1215 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC CDR3 <400> 1215 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1216 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC CDR1 <400> 1216 Arg Phe Ala Met His 1 5 <210> 1217 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC CDR2 <400> 1217 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1218 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC CDR3 <400> 1218 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1219 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC CDR1 <400> 1219 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Thr Val Asn 1 5 10 <210> 1220 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC CDR2 <400> 1220 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1221 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC CDR3 <400> 1221 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1222 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC CDR1 <400> 1222 Arg Phe Ala Met His 1 5 <210> 1223 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC CDR2 <400> 1223 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1224 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC CDR3 <400> 1224 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1225 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC CDR1 <400> 1225 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1226 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC CDR2 <400> 1226 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1227 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC CDR3 <400> 1227 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1228 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC CDR1 <400> 1228 Ser Phe Ala Met His 1 5 <210> 1229 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC CDR2 <400> 1229 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1230 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC CDR3 <400> 1230 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1231 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC CDR1 <400> 1231 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1232 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC CDR2 <400> 1232 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1233 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC CDR3 <400> 1233 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1234 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC CDR1 <400> 1234 Asn Phe Ala Met His 1 5 <210> 1235 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC CDR2 <400> 1235 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1236 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC CDR3 <400> 1236 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1237 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC CDR1 <400> 1237 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1238 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC CDR2 <400> 1238 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1239 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC CDR3 <400> 1239 Ala Thr Trp Asp Asp Ala Leu Ser Gly Trp Val 1 5 10 <210> 1240 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC CDR1 <400> 1240 Arg Phe Ala Met His 1 5 <210> 1241 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC CDR2 <400> 1241 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1242 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC CDR3 <400> 1242 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1243 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC CDR1 <400> 1243 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1244 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC CDR2 <400> 1244 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1245 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC CDR3 <400> 1245 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1246 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC CDR1 <400> 1246 Arg Phe Ala Met His 1 5 <210> 1247 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC CDR2 <400> 1247 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1248 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC CDR3 <400> 1248 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1249 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC CDR1 <400> 1249 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Ala Val Asn 1 5 10 <210> 1250 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC CDR2 <400> 1250 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1251 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC CDR3 <400> 1251 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1252 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC CDR1 <400> 1252 Ser Phe Ala Met His 1 5 <210> 1253 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC CDR2 <400> 1253 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1254 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC CDR3 <400> 1254 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1255 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC CDR1 <400> 1255 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1256 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC CDR2 <400> 1256 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1257 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC CDR3 <400> 1257 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1258 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC CDR1 <400> 1258 Arg Phe Ala Met His 1 5 <210> 1259 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC CDR2 <400> 1259 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1260 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC CDR3 <400> 1260 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1261 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC CDR1 <400> 1261 Ser Gly Ser Arg Ser Asn Ile Gly Gly Asn Thr Val Asn 1 5 10 <210> 1262 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC CDR2 <400> 1262 Gly Asp Asn Gln Arg Pro Ser 1 5 <210> 1263 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC CDR3 <400> 1263 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1264 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC CDR1 <400> 1264 Thr Tyr Ser Met His 1 5 <210> 1265 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC CDR2 <400> 1265 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1266 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC CDR3 <400> 1266 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1267 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC CDR1 <400> 1267 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1268 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC CDR2 <400> 1268 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1269 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC CDR3 <400> 1269 Ala Ala Trp Glu Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1270 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC CDR1 <400> 1270 Asn Phe Ala Met His 1 5 <210> 1271 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC CDR2 <400> 1271 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1272 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC CDR3 <400> 1272 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1273 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC CDR1 <400> 1273 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1274 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC CDR2 <400> 1274 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1275 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC CDR3 <400> 1275 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1276 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC CDR1 <400> 1276 Arg Phe Ala Met His 1 5 <210> 1277 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC CDR2 <400> 1277 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1278 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC CDR3 <400> 1278 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1279 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC CDR1 <400> 1279 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1280 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC CDR2 <400> 1280 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1281 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC CDR3 <400> 1281 Ala Thr Trp Asp Asp Thr Leu Asp Ser Trp Val 1 5 10 <210> 1282 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC CDR1 <400> 1282 Asn Phe Ala Met His 1 5 <210> 1283 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC CDR2 <400> 1283 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1284 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC CDR3 <400> 1284 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1285 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC CDR1 <400> 1285 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1286 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC CDR2 <400> 1286 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1287 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC CDR3 <400> 1287 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1288 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC CDR1 <400> 1288 Ser Phe Ala Met His 1 5 <210> 1289 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC CDR2 <400> 1289 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1290 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC CDR3 <400> 1290 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1291 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC CDR1 <400> 1291 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1292 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC CDR2 <400> 1292 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1293 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC CDR3 <400> 1293 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1294 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC CDR1 <400> 1294 Ser Phe Ala Met His 1 5 <210> 1295 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC CDR2 <400> 1295 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1296 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC CDR3 <400> 1296 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1297 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC CDR1 <400> 1297 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1298 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC CDR2 <400> 1298 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1299 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC CDR3 <400> 1299 Ala Ala Trp Asp Asp Ser Leu Asn Val Trp Val 1 5 10 <210> 1300 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC CDR1 <400> 1300 Arg Phe Ala Met His 1 5 <210> 1301 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC CDR2 <400> 1301 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1302 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC CDR3 <400> 1302 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1303 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC CDR1 <400> 1303 Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn Pro Val Asn 1 5 10 <210> 1304 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC CDR2 <400> 1304 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1305 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC CDR3 <400> 1305 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1306 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC CDR1 <400> 1306 Ser Phe Ala Met His 1 5 <210> 1307 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC CDR2 <400> 1307 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1308 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC CDR3 <400> 1308 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1309 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC CDR1 <400> 1309 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1310 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC CDR2 <400> 1310 Ser Asn Ser Gln Arg Pro Ser 1 5 <210> 1311 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC CDR3 <400> 1311 Ala Gly Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1312 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC CDR1 <400> 1312 Arg Phe Ala Met His 1 5 <210> 1313 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC CDR2 <400> 1313 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1314 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC CDR3 <400> 1314 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1315 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC CDR1 <400> 1315 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1316 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC CDR2 <400> 1316 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1317 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC CDR3 <400> 1317 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1318 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 220 HC CDR1 <400> 1318 Asn Phe Ala Met His 1 5 <210> 1319 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.220 HC CDR2 <400> 1319 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1320 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 220 HC CDR3 <400> 1320 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1321 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC CDR1 <400> 1321 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1322 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC CDR2 <400> 1322 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1323 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC CDR3 <400> 1323 Ala Thr Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1324 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC CDR1 <400> 1324 Arg Phe Ala Met His 1 5 <210> 1325 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC CDR2 <400> 1325 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1326 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC CDR3 <400> 1326 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1327 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC CDR1 <400> 1327 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1328 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC CDR2 <400> 1328 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1329 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC CDR3 <400> 1329 Ala Thr Trp Asp Asp Ala Leu Ser Gly Trp Val 1 5 10 <210> 1330 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC CDR1 <400> 1330 Arg Phe Ala Met His 1 5 <210> 1331 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC CDR2 <400> 1331 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1332 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC CDR3 <400> 1332 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1333 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC CDR1 <400> 1333 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1334 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC CDR2 <400> 1334 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1335 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC CDR3 <400> 1335 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1336 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC CDR1 <400> 1336 Arg Phe Ala Met His 1 5 <210> 1337 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC CDR2 <400> 1337 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1338 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC CDR3 <400> 1338 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1339 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC CDR1 <400> 1339 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1340 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC CDR2 <400> 1340 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1341 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC CDR3 <400> 1341 Ala Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 1342 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC CDR1 <400> 1342 Ser Tyr Ser Met His 1 5 <210> 1343 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC CDR2 <400> 1343 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1344 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC CDR3 <400> 1344 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1345 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC CDR1 <400> 1345 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1346 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC CDR2 <400> 1346 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1347 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC CDR3 <400> 1347 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1348 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC CDR1 <400> 1348 Thr Tyr Ser Met His 1 5 <210> 1349 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC CDR2 <400> 1349 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1350 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC CDR3 <400> 1350 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1351 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC CDR1 <400> 1351 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1352 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC CDR2 <400> 1352 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1353 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC CDR3 <400> 1353 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1354 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC CDR1 <400> 1354 Asn Phe Ala Met His 1 5 <210> 1355 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC CDR2 <400> 1355 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1356 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC CDR3 <400> 1356 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1357 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC CDR1 <400> 1357 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1358 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC CDR2 <400> 1358 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1359 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC CDR3 <400> 1359 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1360 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC CDR1 <400> 1360 Asn Phe Ala Met His 1 5 <210> 1361 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC CDR2 <400> 1361 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1362 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC CDR3 <400> 1362 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1363 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC CDR1 <400> 1363 Ser Gly Ser Ser Ser Asn Val Gly Ser Asn Thr Val Asn 1 5 10 <210> 1364 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC CDR2 <400> 1364 Ser Asn Asp Gln Arg Pro Ser 1 5 <210> 1365 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC CDR3 <400> 1365 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1366 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC CDR1 <400> 1366 Ser Phe Ala Met His 1 5 <210> 1367 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC CDR2 <400> 1367 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1368 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC CDR3 <400> 1368 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1369 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC CDR1 <400> 1369 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1370 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC CDR2 <400> 1370 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1371 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC CDR3 <400> 1371 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1372 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC CDR1 <400> 1372 Arg Phe Ala Met His 1 5 <210> 1373 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC CDR2 <400> 1373 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1374 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC CDR3 <400> 1374 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1375 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC CDR1 <400> 1375 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1376 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC CDR2 <400> 1376 Ser Ser Asn Gln Arg Pro Ser 1 5 <210> 1377 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC CDR3 <400> 1377 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1378 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC CDR1 <400> 1378 Asn Phe Ala Met His 1 5 <210> 1379 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC CDR2 <400> 1379 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1380 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC CDR3 <400> 1380 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1381 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC CDR1 <400> 1381 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1382 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC CDR2 <400> 1382 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1383 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC CDR3 <400> 1383 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1384 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC CDR1 <400> 1384 Ser Phe Ala Met His 1 5 <210> 1385 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC CDR2 <400> 1385 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1386 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC CDR3 <400> 1386 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1387 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC CDR1 <400> 1387 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1388 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC CDR2 <400> 1388 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1389 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC CDR3 <400> 1389 Ala Ala Trp Asp Asp Ser Leu Asn Ala Trp Val 1 5 10 <210> 1390 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC CDR1 <400> 1390 Ser Tyr Ser Met His 1 5 <210> 1391 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC CDR2 <400> 1391 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1392 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC CDR3 <400> 1392 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1393 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 233 LC CDR1 <400> 1393 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1394 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 233 LC CDR2 <400> 1394 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1395 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 233 LC CDR3 <400> 1395 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1396 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 233 HC CDR1 <400> 1396 Arg Phe Ala Met His 1 5 <210> 1397 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 233 HC CDR2 <400> 1397 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1398 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 233 HC CDR3 <400> 1398 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1399 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC CDR1 <400> 1399 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1400 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC CDR2 <400> 1400 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1401 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC CDR3 <400> 1401 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1402 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC CDR1 <400> 1402 Arg Phe Ala Met His 1 5 <210> 1403 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC CDR2 <400> 1403 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1404 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC CDR3 <400> 1404 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1405 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC CDR1 <400> 1405 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1406 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC CDR2 <400> 1406 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1407 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC CDR3 <400> 1407 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1408 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC CDR1 <400> 1408 Ser Tyr Ala Met His 1 5 <210> 1409 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC CDR2 <400> 1409 Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1410 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC CDR3 <400> 1410 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1411 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC CDR1 <400> 1411 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1412 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC CDR2 <400> 1412 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1413 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC CDR3 <400> 1413 Gly Thr Trp Asp Ser Asn Ser Glu Thr Trp Val 1 5 10 <210> 1414 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC CDR1 <400> 1414 Thr Tyr Ser Met His 1 5 <210> 1415 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC CDR2 <400> 1415 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1416 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC CDR3 <400> 1416 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1417 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC CDR1 <400> 1417 Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1418 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC CDR2 <400> 1418 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1419 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC CDR3 <400> 1419 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1420 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC CDR1 <400> 1420 Ser Phe Ala Met His 1 5 <210> 1421 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC CDR2 <400> 1421 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1422 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC CDR3 <400> 1422 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1423 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC CDR1 <400> 1423 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1424 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC CDR2 <400> 1424 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1425 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC CDR3 <400> 1425 Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1426 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC CDR1 <400> 1426 Thr Tyr Ser Met His 1 5 <210> 1427 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC CDR2 <400> 1427 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1428 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC CDR3 <400> 1428 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1429 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC CDR1 <400> 1429 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Thr Val Asn 1 5 10 <210> 1430 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC CDR2 <400> 1430 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1431 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC CDR3 <400> 1431 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1432 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC CDR1 <400> 1432 Asn Phe Ala Met His 1 5 <210> 1433 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC CDR2 <400> 1433 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1434 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC CDR3 <400> 1434 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1435 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC CDR1 <400> 1435 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1436 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC CDR2 <400> 1436 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1437 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC CDR3 <400> 1437 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1438 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC CDR1 <400> 1438 Asn Phe Ala Met His 1 5 <210> 1439 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC CDR2 <400> 1439 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1440 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC CDR3 <400> 1440 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1441 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 241 LC CDR1 <400> 1441 Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn Ser Val Asn 1 5 10 <210> 1442 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 241 LC CDR2 <400> 1442 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1443 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 241 LC CDR3 <400> 1443 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1444 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 241 HC CDR1 <400> 1444 Ser Phe Ala Met His 1 5 <210> 1445 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 241 HC CDR2 <400> 1445 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1446 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 241 HC CDR3 <400> 1446 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1447 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 242 LC CDR1 <400> 1447 Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Thr Val Asn 1 5 10 <210> 1448 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 242 LC CDR2 <400> 1448 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1449 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 242 LC CDR3 <400> 1449 Ala Thr Trp Asp Asp Ser Leu Asn Gly Trp Val 1 5 10 <210> 1450 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 242 HC CDR1 <400> 1450 Ser Phe Ala Met His 1 5 <210> 1451 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 242 HC CDR2 <400> 1451 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Glu Ser Val Lys 1 5 10 15 Gly <210> 1452 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 242 HC CDR3 <400> 1452 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1453 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 243 LC CDR1 <400> 1453 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1454 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 243 LC CDR2 <400> 1454 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1455 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 243 LC CDR3 <400> 1455 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1456 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 243 HC CDR1 <400> 1456 Ser Phe Ala Met His 1 5 <210> 1457 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No. 243 HC CDR2 <400> 1457 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1458 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No. 243 HC CDR3 <400> 1458 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1459 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC CDR1 <400> 1459 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1460 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC CDR2 <400> 1460 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1461 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC CDR3 <400> 1461 Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1462 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC CDR1 <400> 1462 Asn Phe Ala Met His 1 5 <210> 1463 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC CDR2 <400> 1463 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1464 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC CDR3 <400> 1464 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1465 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC CDR1 <400> 1465 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1466 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC CDR2 <400> 1466 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1467 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC CDR3 <400> 1467 Ala Thr Trp Asp Asp Ser Leu Asn Ala Trp Val 1 5 10 <210> 1468 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC CDR1 <400> 1468 Arg Phe Ala Met His 1 5 <210> 1469 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC CDR2 <400> 1469 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1470 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC CDR3 <400> 1470 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1471 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC CDR1 <400> 1471 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1472 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC CDR2 <400> 1472 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1473 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC CDR3 <400> 1473 Ala Thr Trp Asp Asp Ser Leu Asn Gly Tyr Val 1 5 10 <210> 1474 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC CDR1 <400> 1474 Arg Phe Ala Met His 1 5 <210> 1475 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC CDR2 <400> 1475 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1476 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC CDR3 <400> 1476 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1477 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC CDR1 <400> 1477 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1478 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC CDR2 <400> 1478 Ser Asn Gln Arg Pro Ser 1 5 <210> 1479 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC CDR3 <400> 1479 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1480 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC CDR1 <400> 1480 Arg Phe Ala Met His 1 5 <210> 1481 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC CDR2 <400> 1481 Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1482 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC CDR3 <400> 1482 Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro Phe Phe 1 5 10 15 Asp Tyr <210> 1483 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC CDR1 <400> 1483 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1484 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC CDR2 <400> 1484 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1485 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC CDR3 <400> 1485 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1486 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC CDR1 <400> 1486 Thr Ser Gly Val Gly Val Gly 1 5 <210> 1487 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC CDR2 <400> 1487 Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser Leu Lys Thr 1 5 10 15 <210> 1488 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC CDR3 <400> 1488 Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr Tyr Gly Met 1 5 10 15 Asp Val <210> 1489 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC CDR1 <400> 1489 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 1490 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC CDR2 <400> 1490 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 1491 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC CDR3 <400> 1491 Gln Val Trp Asp Gly Ser Ser Asp His Tyr Val 1 5 10 <210> 1492 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC CDR1 <400> 1492 Ser Tyr Ala Met Ser 1 5 <210> 1493 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC CDR2 <400> 1493 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1494 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC CDR3 <400> 1494 Leu Ser His Gly Val Val Gly Ala Gln Asp Ala Phe Asp Ile 1 5 10 <210> 1495 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC CDR1 <400> 1495 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1496 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC CDR2 <400> 1496 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1497 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC CDR3 <400> 1497 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1498 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC CDR1 <400> 1498 Ser Tyr Ala Ile Ser 1 5 <210> 1499 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC CDR2 <400> 1499 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1500 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC CDR3 <400> 1500 Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 1 5 10 <210> 1501 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC CDR1 <400> 1501 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1502 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC CDR2 <400> 1502 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1503 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC CDR3 <400> 1503 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1504 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC CDR1 <400> 1504 Asp Tyr Ala Met His 1 5 <210> 1505 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC CDR2 <400> 1505 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1506 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC CDR3 <400> 1506 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1507 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC CDR1 <400> 1507 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1508 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC CDR2 <400> 1508 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1509 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC CDR3 <400> 1509 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 1510 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC CDR1 <400> 1510 Asp Tyr Ala Met His 1 5 <210> 1511 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC CDR2 <400> 1511 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1512 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC CDR3 <400> 1512 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1513 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC CDR1 <400> 1513 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1514 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC CDR2 <400> 1514 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1515 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC CDR3 <400> 1515 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1516 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC CDR1 <400> 1516 Asp Tyr Ala Met His 1 5 <210> 1517 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC CDR2 <400> 1517 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1518 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC CDR3 <400> 1518 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1519 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC CDR1 <400> 1519 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 1520 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC CDR2 <400> 1520 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 1521 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC CDR3 <400> 1521 Gln Val Trp Asp Ser Ser Ser Asp His Pro Val 1 5 10 <210> 1522 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC CDR1 <400> 1522 Asp Tyr Ala Met His 1 5 <210> 1523 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC CDR2 <400> 1523 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1524 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC CDR3 <400> 1524 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1525 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC CDR1 <400> 1525 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 1526 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC CDR2 <400> 1526 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 1527 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC CDR3 <400> 1527 Gln Ser Tyr Asp Ser Ser Asn His Ala Val 1 5 10 <210> 1528 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC CDR1 <400> 1528 Asp Tyr Ala Met His 1 5 <210> 1529 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC CDR2 <400> 1529 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1530 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC CDR3 <400> 1530 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1531 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC CDR1 <400> 1531 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1532 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC CDR2 <400> 1532 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1533 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC CDR3 <400> 1533 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1534 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC CDR1 <400> 1534 Asp Tyr Ala Met His 1 5 <210> 1535 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC CDR2 <400> 1535 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1536 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC CDR3 <400> 1536 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1537 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC CDR1 <400> 1537 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1538 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC CDR2 <400> 1538 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1539 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC CDR3 <400> 1539 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1540 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC CDR1 <400> 1540 Asp Tyr Ala Met His 1 5 <210> 1541 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC CDR2 <400> 1541 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1542 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC CDR3 <400> 1542 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1543 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC CDR1 <400> 1543 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1544 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC CDR2 <400> 1544 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1545 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC CDR3 <400> 1545 Gly Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 <210> 1546 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC CDR1 <400> 1546 Asp Tyr Ala Met His 1 5 <210> 1547 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC CDR2 <400> 1547 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1548 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC CDR3 <400> 1548 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1549 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC CDR1 <400> 1549 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1550 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC CDR2 <400> 1550 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1551 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC CDR3 <400> 1551 Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 1 5 10 <210> 1552 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC CDR1 <400> 1552 Asp Tyr Ala Met His 1 5 <210> 1553 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC CDR2 <400> 1553 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1554 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC CDR3 <400> 1554 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1555 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC CDR1 <400> 1555 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1556 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC CDR2 <400> 1556 Thr Asn Asn Gln Arg Pro Ser 1 5 <210> 1557 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC CDR3 <400> 1557 Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val 1 5 10 <210> 1558 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC CDR1 <400> 1558 Asp Tyr Ala Met His 1 5 <210> 1559 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC CDR2 <400> 1559 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1560 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC CDR3 <400> 1560 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1561 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC CDR1 <400> 1561 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1562 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC CDR2 <400> 1562 Asp Asn Asp Lys Arg Pro Ser 1 5 <210> 1563 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC CDR3 <400> 1563 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val 1 5 10 <210> 1564 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 261 HC CDR1 <400> 1564 Asp Tyr Ala Met His 1 5 <210> 1565 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.261 HC CDR2 <400> 1565 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1566 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No. 261 HC CDR3 <400> 1566 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1567 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC CDR1 <400> 1567 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1568 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC CDR2 <400> 1568 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1569 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC CDR3 <400> 1569 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Tyr Val 1 5 10 <210> 1570 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC CDR1 <400> 1570 Asp Tyr Ala Met His 1 5 <210> 1571 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC CDR2 <400> 1571 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1572 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC CDR3 <400> 1572 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1573 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC CDR1 <400> 1573 Ser Gly Ser Ser Pro Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1574 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC CDR2 <400> 1574 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1575 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC CDR3 <400> 1575 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val 1 5 10 <210> 1576 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC CDR1 <400> 1576 Asp Tyr Ala Met His 1 5 <210> 1577 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC CDR2 <400> 1577 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1578 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC CDR3 <400> 1578 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1579 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC CDR1 <400> 1579 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1580 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC CDR2 <400> 1580 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1581 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC CDR3 <400> 1581 Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val 1 5 10 <210> 1582 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC CDR1 <400> 1582 Asp Tyr Ala Met His 1 5 <210> 1583 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC CDR2 <400> 1583 Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val Lys 1 5 10 15 Gly <210> 1584 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC CDR3 <400> 1584 Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val 1 5 10 <210> 1585 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC CDR1 <400> 1585 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1586 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC CDR2 <400> 1586 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1587 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC CDR3 <400> 1587 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val 1 5 10 <210> 1588 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC CDR1 <400> 1588 Ser Asn Tyr Met Thr 1 5 <210> 1589 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC CDR2 <400> 1589 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1590 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC CDR3 <400> 1590 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1591 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC CDR1 <400> 1591 Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 1 5 10 <210> 1592 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC CDR2 <400> 1592 Tyr Asp Ser Asp Arg Pro Ser 1 5 <210> 1593 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC CDR3 <400> 1593 Gln Val Arg Asp Ser Ser Ser Asp His Pro Val 1 5 10 <210> 1594 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC CDR1 <400> 1594 Ser Asn Tyr Met Thr 1 5 <210> 1595 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC CDR2 <400> 1595 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1596 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC CDR3 <400> 1596 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1597 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC CDR1 <400> 1597 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1598 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC CDR2 <400> 1598 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1599 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC CDR3 <400> 1599 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val 1 5 10 <210> 1600 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC CDR1 <400> 1600 Ser Asn Tyr Met Thr 1 5 <210> 1601 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC CDR2 <400> 1601 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1602 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC CDR3 <400> 1602 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1603 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC CDR1 <400> 1603 Thr Gly Ser Asp Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1604 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC CDR2 <400> 1604 Asn Asn Asn Asn Arg Pro Ser 1 5 <210> 1605 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC CDR3 <400> 1605 Gln Ser Ser Asp Ser Gly Leu Thr Gly Trp Val 1 5 10 <210> 1606 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC CDR1 <400> 1606 Ser Asn Tyr Met Thr 1 5 <210> 1607 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC CDR2 <400> 1607 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1608 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC CDR3 <400> 1608 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1609 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC CDR1 <400> 1609 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1610 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC CDR2 <400> 1610 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1611 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC CDR3 <400> 1611 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1612 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC CDR1 <400> 1612 Ser Asn Tyr Met Thr 1 5 <210> 1613 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC CDR2 <400> 1613 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1614 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC CDR3 <400> 1614 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1615 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC CDR1 <400> 1615 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 1616 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC CDR2 <400> 1616 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 1617 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC CDR3 <400> 1617 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 1618 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC CDR1 <400> 1618 Ser Asn Tyr Met Thr 1 5 <210> 1619 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC CDR2 <400> 1619 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1620 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC CDR3 <400> 1620 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1621 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC CDR1 <400> 1621 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1622 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC CDR2 <400> 1622 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1623 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC CDR3 <400> 1623 Ser Ser Tyr Ala Gly Ser Asn Asn Leu Val 1 5 10 <210> 1624 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC CDR1 <400> 1624 Ser Asn Tyr Met Thr 1 5 <210> 1625 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC CDR2 <400> 1625 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1626 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC CDR3 <400> 1626 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1627 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC CDR1 <400> 1627 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1628 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC CDR2 <400> 1628 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1629 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC CDR3 <400> 1629 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1630 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC CDR1 <400> 1630 Ser Asn Tyr Met Thr 1 5 <210> 1631 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC CDR2 <400> 1631 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1632 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC CDR3 <400> 1632 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1633 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC CDR1 <400> 1633 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 1634 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC CDR2 <400> 1634 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 1635 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC CDR3 <400> 1635 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 <210> 1636 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC CDR1 <400> 1636 Ser Asn Tyr Met Thr 1 5 <210> 1637 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC CDR2 <400> 1637 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1638 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC CDR3 <400> 1638 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1639 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC CDR1 <400> 1639 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1640 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC CDR2 <400> 1640 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1641 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC CDR3 <400> 1641 Gln Ser Tyr Asp Ser Ser Leu Gly Val Val 1 5 10 <210> 1642 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC CDR1 <400> 1642 Ser Asn Tyr Met Thr 1 5 <210> 1643 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC CDR2 <400> 1643 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1644 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC CDR3 <400> 1644 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1645 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC CDR1 <400> 1645 Gly Gly Asn Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 <210> 1646 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC CDR2 <400> 1646 Ser Asn Asn Leu Arg Pro Ser 1 5 <210> 1647 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC CDR3 <400> 1647 Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 1 5 10 <210> 1648 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC CDR1 <400> 1648 Ser Asn Tyr Met Thr 1 5 <210> 1649 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC CDR2 <400> 1649 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1650 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC CDR3 <400> 1650 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1651 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC CDR1 <400> 1651 Ser Gly Ser Ser Ser Asn Ile Gly Gly Ser Asp Val Gly 1 5 10 <210> 1652 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC CDR2 <400> 1652 Lys Ser Asn Gln Arg Pro Ser 1 5 <210> 1653 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC CDR3 <400> 1653 Ala Thr Trp Asp Asp Arg Leu Asn Trp Val 1 5 10 <210> 1654 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC CDR1 <400> 1654 Ser Asn Tyr Met Thr 1 5 <210> 1655 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC CDR2 <400> 1655 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1656 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC CDR3 <400> 1656 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1657 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC CDR1 <400> 1657 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 <210> 1658 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC CDR2 <400> 1658 Ala Ala Ser Ser Leu Gln Ser 1 5 <210> 1659 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC CDR3 <400> 1659 Gln Gln Ser Tyr Ser Thr Pro Phe Thr 1 5 <210> 1660 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC CDR1 <400> 1660 Asn Tyr Tyr Met His 1 5 <210> 1661 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC CDR2 <400> 1661 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1662 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC CDR3 <400> 1662 Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr 1 5 10 <210> 1663 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC CDR1 <400> 1663 Gln Ala Gly Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 1664 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC CDR2 <400> 1664 Lys Ala Ser Ser Leu Glu Ser 1 5 <210> 1665 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC CDR3 <400> 1665 Gln Gln Ala His Ser Phe Pro Phe Thr 1 5 <210> 1666 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC CDR1 <400> 1666 Ser Tyr Tyr Met His 1 5 <210> 1667 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC CDR2 <400> 1667 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1668 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC CDR3 <400> 1668 Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr 1 5 10 <210> 1669 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC CDR1 <400> 1669 Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 1 5 10 <210> 1670 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC CDR2 <400> 1670 Asp Ala Ser Asn Leu Glu Thr 1 5 <210> 1671 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC CDR3 <400> 1671 Gln Gln Ser Tyr Ser Thr Leu Pro Thr 1 5 <210> 1672 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC CDR1 <400> 1672 Ser Tyr Tyr Met His 1 5 <210> 1673 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC CDR2 <400> 1673 Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1674 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC CDR3 <400> 1674 Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr 1 5 10 <210> 1675 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC CDR1 <400> 1675 Thr Gly Ser Ser Ser Asn Thr Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1676 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC CDR2 <400> 1676 Ser Asn Asn Gln Arg Pro Ser 1 5 <210> 1677 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC CDR3 <400> 1677 Ala Ala Trp Asp Asp Ser Leu Asn Gly Gly Val 1 5 10 <210> 1678 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC CDR1 <400> 1678 Ser Asn Tyr Met Ser 1 5 <210> 1679 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC CDR2 <400> 1679 Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1680 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC CDR3 <400> 1680 Asp Leu Ile Val Tyr Gly Met Asp Val 1 5 <210> 1681 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No. 281 LC CDR1 <400> 1681 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1682 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No. 281 LC CDR2 <400> 1682 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1683 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No. 281 LC CDR3 <400> 1683 Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 1 5 10 <210> 1684 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No. 281 HC CDR1 <400> 1684 Ser Asn Tyr Met Ser 1 5 <210> 1685 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.281 HC CDR2 <400> 1685 Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1686 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No. 281 HC CDR3 <400> 1686 Asp Leu Ile Val Tyr Gly Met Asp Val 1 5 <210> 1687 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC CDR1 <400> 1687 Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1688 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC CDR2 <400> 1688 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1689 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC CDR3 <400> 1689 Ala Ala Trp Asp Asp Ser Leu Asn Gly Gly Val 1 5 10 <210> 1690 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC CDR1 <400> 1690 Ser Asn Tyr Met Ser 1 5 <210> 1691 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC CDR2 <400> 1691 Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1692 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC CDR3 <400> 1692 Asp Leu Ile Val Tyr Gly Met Asp Val 1 5 <210> 1693 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC CDR1 <400> 1693 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 <210> 1694 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC CDR2 <400> 1694 Asp Ala Ser Asn Arg Ala Thr 1 5 <210> 1695 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC CDR3 <400> 1695 Gln Gln Tyr Gly Ser Ser Pro Pro Tyr Thr 1 5 10 <210> 1696 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC CDR1 <400> 1696 Ser Asn Tyr Met Ser 1 5 <210> 1697 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC CDR2 <400> 1697 Val Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1698 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC CDR3 <400> 1698 Asp Leu Arg Gly Val Leu Asp Tyr 1 5 <210> 1699 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC CDR1 <400> 1699 Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1700 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC CDR2 <400> 1700 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1701 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC CDR3 <400> 1701 Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 1 5 10 <210> 1702 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC CDR1 <400> 1702 Ser Asn Tyr Met Ser 1 5 <210> 1703 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC CDR2 <400> 1703 Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1704 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC CDR3 <400> 1704 Gly His Val Asp Ile Pro Tyr Gly Met Asp Val 1 5 10 <210> 1705 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC CDR1 <400> 1705 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1706 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC CDR2 <400> 1706 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1707 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC CDR3 <400> 1707 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1708 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC CDR1 <400> 1708 Ser Tyr Ala Ile Ser 1 5 <210> 1709 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC CDR2 <400> 1709 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1710 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC CDR3 <400> 1710 Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp Pro 1 5 10 15 <210> 1711 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC CDR1 <400> 1711 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1712 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC CDR2 <400> 1712 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1713 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC CDR3 <400> 1713 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1714 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC CDR1 <400> 1714 Ser Tyr Ala Ile Ser 1 5 <210> 1715 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC CDR2 <400> 1715 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1716 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC CDR3 <400> 1716 Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp Pro 1 5 10 15 <210> 1717 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC CDR1 <400> 1717 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1718 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC CDR2 <400> 1718 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1719 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC CDR3 <400> 1719 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1720 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC CDR1 <400> 1720 Ser Tyr Ala Ile Ser 1 5 <210> 1721 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC CDR2 <400> 1721 Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly <210> 1722 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC CDR3 <400> 1722 Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 1 5 10 <210> 1723 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC CDR1 <400> 1723 Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 1 5 10 <210> 1724 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC CDR2 <400> 1724 Glu Asp Asn Gln Arg Pro Ser 1 5 <210> 1725 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC CDR3 <400> 1725 Gln Ser Tyr Asp Ser Ser Asn His Trp Val 1 5 10 <210> 1726 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC CDR1 <400> 1726 Ser Tyr Ala Met His 1 5 <210> 1727 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC CDR2 <400> 1727 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1728 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC CDR3 <400> 1728 Ala Asn Leu Gly Tyr Cys Thr Asn Gly Val Cys Ala Pro Ser Gly Gly 1 5 10 15 <210> 1729 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC CDR1 <400> 1729 Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 1 5 10 <210> 1730 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC CDR2 <400> 1730 Asp Asn Asn Lys Arg Pro Ser 1 5 <210> 1731 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC CDR3 <400> 1731 Gly Thr Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 <210> 1732 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC CDR1 <400> 1732 Asp Tyr Ala Met His 1 5 <210> 1733 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC CDR2 <400> 1733 Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 1734 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC CDR3 <400> 1734 Asn Leu Arg Tyr Phe Asp Trp Leu Leu Gly Asp Asp Ala Phe Asp Ile 1 5 10 15 <210> 1735 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC CDR1 <400> 1735 Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 1 5 10 <210> 1736 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC CDR2 <400> 1736 Gly Asn Ser Asn Arg Pro Ser 1 5 <210> 1737 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC CDR3 <400> 1737 Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val 1 5 10 <210> 1738 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC CDR1 <400> 1738 Ser Asn Tyr Met Thr 1 5 <210> 1739 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC CDR2 <400> 1739 Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 <210> 1740 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC CDR3 <400> 1740 Asp Leu Val Val Tyr Gly Met Asp Val 1 5 <210> 1741 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.1 LC variable region <400> 1741 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1742 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.1 HC variable region <400> 1742 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu 100 105 110 Asp Ala Phe Asp Ile Trp Gly Gly Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 1743 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.2 LC variable region <400> 1743 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Val Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro His 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1744 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.2 HC variable region <400> 1744 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Gly Asp Cys Gly Gly Asp Cys Tyr Ser Phe Leu Leu Gly Glu 100 105 110 Asp Ala Phe Asp Ile Trp Gly Gly Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 1745 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.3 LC variable region <400> 1745 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1746 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.3 HC variable region <400> 1746 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr 100 105 110 Ser Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1747 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.4 LC variable region <400> 1747 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asp Leu Pro Ile 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1748 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.4 HC variable region <400> 1748 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr 100 105 110 Ser Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1749 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.5 LC variable region <400> 1749 Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1750 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.5 HC variable region <400> 1750 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Leu Val Ser Gly Arg Tyr Cys Ser Gly Val Thr Cys Tyr 100 105 110 Ser Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1751 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.6 LC variable region <400> 1751 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1752 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.6 HC variable region <400> 1752 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1753 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.7 LC variable region <400> 1753 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1754 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.7 HC variable region <400> 1754 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1755 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.8 LC variable region <400> 1755 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1756 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.8 HC variable region <400> 1756 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1757 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.9 LC variable region <400> 1757 Glu Leu Glu Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1758 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.9 HC variable region <400> 1758 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1759 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.10 LC variable region <400> 1759 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1760 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.10 HC variable region <400> 1760 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1761 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.11 LC variable region <400> 1761 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1762 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.11 HC variable region <400> 1762 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Glu Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1763 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.12 LC variable region <400> 1763 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1764 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.12 HC variable region <400> 1764 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1765 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.13 LC variable region <400> 1765 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Gly Asn Tyr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1766 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.13 HC variable region <400> 1766 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1767 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.14 LC variable region <400> 1767 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 20 25 30 Tyr Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Arg Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1768 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.14 HC variable region <400> 1768 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1769 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.15 LC variable region <400> 1769 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1770 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.15 HC variable region <400> 1770 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1771 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.16 LC variable region <400> 1771 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1772 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.16 HC variable region <400> 1772 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1773 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.17 LC variable region <400> 1773 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1774 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.17 HC variable region <400> 1774 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1775 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.18 LC variable region <400> 1775 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1776 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.18 HC variable region <400> 1776 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1777 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.19 LC variable region <400> 1777 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1778 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.19 HC variable region <400> 1778 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1779 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.20 LC variable region <400> 1779 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1780 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.20 HC variable region <400> 1780 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1781 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.21 LC variable region <400> 1781 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1782 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.21 HC variable region <400> 1782 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1783 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.22 LC variable region <400> 1783 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1784 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.22 HC variable region <400> 1784 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1785 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.23 LC variable region <400> 1785 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1786 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.23 HC variable region <400> 1786 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1787 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.24 LC variable region <400> 1787 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1788 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.24 HC variable region <400> 1788 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1789 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.25 LC variable region <400> 1789 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1790 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.25 HC variable region <400> 1790 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1791 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.26 LC variable region <400> 1791 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1792 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.26 HC variable region <400> 1792 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1793 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.27 LC variable region <400> 1793 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1794 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.27 HC variable region <400> 1794 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1795 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.28 LC variable region <400> 1795 Glu Leu Glu Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1796 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.28 HC variable region <400> 1796 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1797 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.29 LC variable region <400> 1797 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1798 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.29 HC variable region <400> 1798 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1799 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.30 LC variable region <400> 1799 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1800 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.30 HC variable region <400> 1800 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1801 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.31 LC variable region <400> 1801 Glu Leu Gly Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 20 25 30 Tyr Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1802 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.31 HC variable region <400> 1802 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1803 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.32 LC variable region <400> 1803 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1804 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.32 HC variable region <400> 1804 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1805 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.33 LC variable region <400> 1805 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1806 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.33 HC variable region <400> 1806 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1807 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.34 LC variable region <400> 1807 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1808 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.34 HC variable region <400> 1808 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Thr Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1809 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.35 LC variable region <400> 1809 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1810 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.35 HC variable region <400> 1810 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1811 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.36 LC variable region <400> 1811 Glu Leu Val Val Thr Gln Pro Ser Ala Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1812 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.36 HC variable region <400> 1812 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1813 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.37 LC variable region <400> 1813 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1814 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.37 HC variable region <400> 1814 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1815 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.38 LC variable region <400> 1815 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1816 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.38 HC variable region <400> 1816 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1817 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.39 LC variable region <400> 1817 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1818 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.39 HC variable region <400> 1818 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1819 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.40 LC variable region <400> 1819 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1820 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.40 HC variable region <400> 1820 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1821 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.41 LC variable region <400> 1821 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1822 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.41 HC variable region <400> 1822 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1823 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.42 LC variable region <400> 1823 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Lys Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1824 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.42 HC variable region <400> 1824 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1825 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.43 LC variable region <400> 1825 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Arg Asn Asn Gln Arg Pro Pro Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Arg Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1826 <211> 131 <212> PRT <213> Artificial Sequence <220> <223> No.43 HC variable region <400> 1826 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Gly Val Val Val Pro Ala Val Met Tyr Asp Thr Thr Asp 100 105 110 Pro Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 115 120 125 Val Ser Ser 130 <210> 1827 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.44 LC variable region <400> 1827 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Val Thr Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1828 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.44 HC variable region <400> 1828 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Arg Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Pro Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1829 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.45 LC variable region <400> 1829 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1830 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.45 HC variable region <400> 1830 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1831 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.46 LC variable region <400> 1831 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1832 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.46 HC variable region <400> 1832 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1833 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.47 LC variable region <400> 1833 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1834 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.47 HC variable region <400> 1834 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1835 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.48 LC variable region <400> 1835 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1836 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.48 HC variable region <400> 1836 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Ser His Tyr 20 25 30 Phe Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser Thr Gly 100 105 110 Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 1837 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.49 LC variable region <400> 1837 Glu Leu Ala Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1838 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.49 HC variable region <400> 1838 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1839 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.50 LC variable region <400> 1839 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1840 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.50 HC variable region <400> 1840 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1841 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.51 LC variable region <400> 1841 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1842 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.51 HC variable region <400> 1842 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1843 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.52 LC variable region <400> 1843 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1844 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.52 HC variable region <400> 1844 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1845 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.53 LC variable region <400> 1845 Glu Leu Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Gly Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Ala Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1846 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.53 HC variable region <400> 1846 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1847 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.54 LC variable region <400> 1847 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Ala Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr His Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1848 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.54 HC variable region <400> 1848 Arg Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1849 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.55 LC variable region <400> 1849 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser 85 90 95 Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1850 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.55 HC variable region <400> 1850 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1851 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.56 LC variable region <400> 1851 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 1852 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.56 HC variable region <400> 1852 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1853 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.57 LC variable region <400> 1853 Glu Leu Val Met Thr Gln Ser Pro Gly Ile Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1854 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.57 HC variable region <400> 1854 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1855 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.58 LC variable region <400> 1855 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1856 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.58 HC variable region <400> 1856 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1857 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.59 LC variable region <400> 1857 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1858 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.59 HC variable region <400> 1858 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1859 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.60 LC variable region <400> 1859 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Pro Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1860 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.60 HC variable region <400> 1860 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1861 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.61 LC variable region <400> 1861 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Ser 85 90 95 Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1862 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.61 HC variable region <400> 1862 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1863 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.62 LC variable region <400> 1863 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1864 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.62 HC variable region <400> 1864 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1865 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.63 LC variable region <400> 1865 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1866 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.63 HC variable region <400> 1866 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Val Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1867 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.64 LC variable region <400> 1867 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1868 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.64 HC variable region <400> 1868 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1869 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.65 LC variable region <400> 1869 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Ser Ala Thr Leu Ala Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Phe Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 1870 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.65 HC variable region <400> 1870 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1871 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.66 LC variable region <400> 1871 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1872 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.66 HC variable region <400> 1872 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1873 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.67 LC variable region <400> 1873 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1874 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.67 HC variable region <400> 1874 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1875 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.68 LC variable region <400> 1875 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Pro Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 100 105 110 <210> 1876 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.68 HC variable region <400> 1876 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Val Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1877 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.69 LC variable region <400> 1877 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile His Ala Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Val Glu 65 70 75 80 Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Asp Ser Leu 85 90 95 Ser Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1878 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.69 HC variable region <400> 1878 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1879 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.70 LC variable region <400> 1879 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser 85 90 95 Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1880 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.70 HC variable region <400> 1880 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1881 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.71 LC variable region <400> 1881 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1882 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.71 HC variable region <400> 1882 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1883 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.72 LC variable region <400> 1883 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met 35 40 45 Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 65 70 75 80 Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser Ser 85 90 95 Thr Leu Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 <210> 1884 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.72 HC variable region <400> 1884 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1885 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.73 LC variable region <400> 1885 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Ser Ala Thr Leu Ala Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Phe Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Glu Tyr Gly Ser Ser Pro 85 90 95 Gly Arg Val Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 110 <210> 1886 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.73 HC variable region <400> 1886 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Pro Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1887 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.74 LC variable region <400> 1887 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1888 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.74 HC variable region <400> 1888 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1889 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.75 LC variable region <400> 1889 Glu Leu Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1890 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.75 HC variable region <400> 1890 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1891 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.76 LC variable region <400> 1891 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1892 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.76 HC variable region <400> 1892 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1893 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.77 LC variable region <400> 1893 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 1894 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.77 HC variable region <400> 1894 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1895 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.78 LC variable region <400> 1895 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1896 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.78 HC variable region <400> 1896 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1897 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.79 LC variable region <400> 1897 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 65 70 75 80 Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Ser 85 90 95 Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1898 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.79 HC variable region <400> 1898 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1899 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.80 LC variable region <400> 1899 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1900 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.80 HC variable region <400> 1900 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1901 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.81 LC variable region <400> 1901 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1902 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.81 HC variable region <400> 1902 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1903 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.82 LC variable region <400> 1903 Glu Leu Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 1904 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.82 HC variable region <400> 1904 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1905 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.83 LC variable region <400> 1905 Glu Leu Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1906 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.83 HC variable region <400> 1906 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Gly Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1907 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.84 LC variable region <400> 1907 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 85 90 95 Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1908 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.84 HC variable region <400> 1908 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Val Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1909 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.85 LC variable region <400> 1909 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1910 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.85 HC variable region <400> 1910 Gln Val Gln Leu Gln Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1911 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.86 LC variable region <400> 1911 Glu Leu Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Arg Ala Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 <210> 1912 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.86 HC variable region <400> 1912 Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1913 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.87 LC variable region <400> 1913 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1914 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.87 HC variable region <400> 1914 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser 115 120 125 Ser <210> 1915 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.88 LC variable region <400> 1915 Glu Leu Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Ser 85 90 95 Ile Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 1916 <211> 129 <212> PRT <213> Artificial Sequence <220> <223> No.88 HC variable region <400> 1916 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 20 25 30 Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Asn Leu Ser Ser Ala Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Gly Ser Arg Gly Tyr Tyr Asp Phe Leu Thr Gly Tyr Ser 100 105 110 Thr Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Ala Val Ser 115 120 125 Ser <210> 1917 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.89 LC variable region <400> 1917 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Arg Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1918 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.89 HC variable region <400> 1918 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1919 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.90 LC variable region <400> 1919 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1920 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.90 HC variable region <400> 1920 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1921 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.91 LC variable region <400> 1921 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1922 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.91 HC variable region <400> 1922 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ala Gln 1 5 10 15 Thr Leu Arg Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Phe Ser 115 120 125 <210> 1923 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.92 LC variable region <400> 1923 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1924 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.92 HC variable region <400> 1924 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1925 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.93 LC variable region <400> 1925 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Arg Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1926 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.93 HC variable region <400> 1926 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Val Asp Val Trp Gly Gin Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1927 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.94 LC variable region <400> 1927 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1928 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.94 HC variable region <400> 1928 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1929 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.95 LC variable region <400> 1929 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1930 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.95 HC variable region <400> 1930 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1931 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.96 LC variable region <400> 1931 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1932 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.96 HC variable region <400> 1932 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1933 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.97 LC variable region <400> 1933 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1934 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.97 HC variable region <400> 1934 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Ser Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1935 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.98 LC variable region <400> 1935 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1936 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.98 HC variable region <400> 1936 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1937 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.99 LC variable region <400> 1937 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1938 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.99 HC variable region <400> 1938 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1939 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.100 LC variable region <400> 1939 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1940 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.100 HC variable region <400> 1940 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1941 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.101 LC variable region <400> 1941 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1942 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.101 HC variable region <400> 1942 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1943 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.102 LC variable region <400> 1943 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1944 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.102 HC variable region <400> 1944 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1945 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.103 LC variable region <400> 1945 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1946 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.103 HC variable region <400> 1946 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1947 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.104 LC variable region <400> 1947 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1948 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.104 HC variable region <400> 1948 Gln Val Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1949 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.105 LC variable region <400> 1949 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1950 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.105 HC variable region <400> 1950 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1951 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.106 LC variable region <400> 1951 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1952 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.106 HC variable region <400> 1952 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1953 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.107 LC variable region <400> 1953 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1954 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.107 HC variable region <400> 1954 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1955 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.108 LC variable region <400> 1955 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1956 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.108 HC variable region <400> 1956 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1957 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.109 LC variable region <400> 1957 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1958 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.109 HC variable region <400> 1958 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1959 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.110 LC variable region <400> 1959 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1960 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.110 HC variable region <400> 1960 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1961 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.111 LC variable region <400> 1961 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1962 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.111 HC variable region <400> 1962 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1963 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.112 LC variable region <400> 1963 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1964 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.112 HC variable region <400> 1964 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1965 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.113 LC variable region <400> 1965 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Ile Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1966 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.113 HC variable region <400> 1966 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1967 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.114 LC variable region <400> 1967 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1968 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.114 HC variable region <400> 1968 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1969 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.115 LC variable region <400> 1969 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1970 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.115 HC variable region <400> 1970 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1971 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.116 LC variable region <400> 1971 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1972 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.116 HC variable region <400> 1972 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1973 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.117 LC variable region <400> 1973 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1974 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.117 HC variable region <400> 1974 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1975 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.118 LC variable region <400> 1975 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1976 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.118 HC variable region <400> 1976 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1977 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.119 LC variable region <400> 1977 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1978 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.119 HC variable region <400> 1978 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1979 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.120 LC variable region <400> 1979 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 1980 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.120 HC variable region <400> 1980 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Thr Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1981 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.121 LC variable region <400> 1981 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 1982 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.121 HC variable region <400> 1982 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1983 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.122 LC variable region <400> 1983 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1984 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.122 HC variable region <400> 1984 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1985 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.123 LC variable region <400> 1985 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1986 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.123 HC variable region <400> 1986 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1987 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.124 LC variable region <400> 1987 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1988 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.124 HC variable region <400> 1988 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ala Gln 1 5 10 15 Thr Leu Arg Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Phe Ser 115 120 125 <210> 1989 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.125 LC variable region <400> 1989 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1990 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.125 HC variable region <400> 1990 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1991 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.126 LC variable region <400> 1991 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1992 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.126 HC variable region <400> 1992 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1993 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.127 LC variable region <400> 1993 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1994 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.127 HC variable region <400> 1994 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ala Gln 1 5 10 15 Thr Leu Arg Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Phe Ser 115 120 125 <210> 1995 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.128 LC variable region <400> 1995 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn 20 25 30 Phe Val Ser Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 1996 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.128 HC variable region <400> 1996 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1997 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.129 LC variable region <400> 1997 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Ser Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Asn Leu 85 90 95 Ser Ala Gly Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 1998 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.129 HC variable region <400> 1998 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 1999 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.130 LC variable region <400> 1999 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2000 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.130 HC variable region <400> 2000 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2001 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.131 LC variable region <400> 2001 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2002 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.131 HC variable region <400> 2002 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2003 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.132 LC variable region <400> 2003 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2004 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.132 HC variable region <400> 2004 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2005 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.133 LC variable region <400> 2005 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2006 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.133 HC variable region <400> 2006 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2007 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.134 LC variable region <400> 2007 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2008 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.134 HC variable region <400> 2008 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2009 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.135 LC variable region <400> 2009 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2010 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.135 HC variable region <400> 2010 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2011 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.136 LC variable region <400> 2011 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2012 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.136 HC variable region <400> 2012 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2013 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.137 LC variable region <400> 2013 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2014 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.137 HC variable region <400> 2014 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2015 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.138 LC variable region <400> 2015 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2016 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.138 HC variable region <400> 2016 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2017 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.139 LC variable region <400> 2017 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2018 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.139 HC variable region <400> 2018 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr His Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2019 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.140 LC variable region <400> 2019 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2020 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.140 HC variable region <400> 2020 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Ser Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2021 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.141 LC variable region <400> 2021 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2022 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.141 HC variable region <400> 2022 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2023 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.142 LC variable region <400> 2023 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2024 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.142 HC variable region <400> 2024 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2025 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.143 LC variable region <400> 2025 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2026 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.143 HC variable region <400> 2026 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2027 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.144 LC variable region <400> 2027 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2028 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.144 HC variable region <400> 2028 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2029 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.145 LC variable region <400> 2029 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2030 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.145 HC variable region <400> 2030 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2031 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.146 LC variable region <400> 2031 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2032 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.146 HC variable region <400> 2032 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2033 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.147 LC variable region <400> 2033 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2034 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.147 HC variable region <400> 2034 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Phe Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2035 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.148 LC variable region <400> 2035 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2036 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.148 HC variable region <400> 2036 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2037 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.149 LC variable region <400> 2037 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2038 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.149 HC variable region <400> 2038 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2039 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.150 LC variable region <400> 2039 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2040 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.150 HC variable region <400> 2040 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2041 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.151 LC variable region <400> 2041 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2042 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.151 HC variable region <400> 2042 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2043 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.152 LC variable region <400> 2043 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2044 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.152 HC variable region <400> 2044 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2045 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.153 LC variable region <400> 2045 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2046 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.153 HC variable region <400> 2046 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2047 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.154 LC variable region <400> 2047 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2048 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.154 HC variable region <400> 2048 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2049 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.155 LC variable region <400> 2049 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2050 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.155 HC variable region <400> 2050 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2051 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.156 LC variable region <400> 2051 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2052 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.156 HC variable region <400> 2052 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2053 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.157 LC variable region <400> 2053 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2054 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.157 HC variable region <400> 2054 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2055 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.158 LC variable region <400> 2055 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2056 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.158 HC variable region <400> 2056 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2057 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.159 LC variable region <400> 2057 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2058 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.159 HC variable region <400> 2058 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2059 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.160 LC variable region <400> 2059 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2060 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.160 HC variable region <400> 2060 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2061 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.161 LC variable region <400> 2061 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2062 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.161 HC variable region <400> 2062 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2063 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.162 LC variable region <400> 2063 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2064 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.162 HC variable region <400> 2064 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2065 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.163 LC variable region <400> 2065 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2066 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.163 HC variable region <400> 2066 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2067 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.164 LC variable region <400> 2067 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2068 <211> 133 <212> PRT <213> Artificial Sequence <220> <223> No.164 HC variable region <400> 2068 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Pro Arg Asp His Gly His Arg Leu Leu 115 120 125 Ser Phe His Gln Gly 130 <210> 2069 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.165 LC variable region <400> 2069 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2070 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.165 HC variable region <400> 2070 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2071 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.166 LC variable region <400> 2071 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2072 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.166 HC variable region <400> 2072 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2073 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.167 LC variable region <400> 2073 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2074 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.167 HC variable region <400> 2074 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2075 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.168 LC variable region <400> 2075 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2076 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.168 HC variable region <400> 2076 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2077 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.169 LC variable region <400> 2077 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Lys Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2078 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.169 HC variable region <400> 2078 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2079 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.170 LC variable region <400> 2079 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2080 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.170 HC variable region <400> 2080 Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2081 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.171 LC variable region <400> 2081 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2082 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.171 HC variable region <400> 2082 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2083 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.172 LC variable region <400> 2083 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Ala Leu 100 105 110 <210> 2084 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.172 HC variable region <400> 2084 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Pro Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2085 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.173 LC variable region <400> 2085 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2086 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.173 HC variable region <400> 2086 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2087 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.174 LC variable region <400> 2087 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2088 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.174 HC variable region <400> 2088 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2089 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.175 LC variable region <400> 2089 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2090 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.175 HC variable region <400> 2090 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2091 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.176 LC variable region <400> 2091 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2092 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.176 HC variable region <400> 2092 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2093 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.177 LC variable region <400> 2093 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2094 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.177 HC variable region <400> 2094 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2095 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.178 LC variable region <400> 2095 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2096 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.178 HC variable region <400> 2096 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2097 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.179 LC variable region <400> 2097 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2098 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.179 HC variable region <400> 2098 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2099 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.180 LC variable region <400> 2099 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2100 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.180 HC variable region <400> 2100 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2101 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.181 LC variable region <400> 2101 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2102 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.181 HC variable region <400> 2102 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2103 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.182 LC variable region <400> 2103 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2104 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.182 HC variable region <400> 2104 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2105 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.183 LC variable region <400> 2105 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2106 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.183 HC variable region <400> 2106 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2107 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.184 LC variable region <400> 2107 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Arg Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asp Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2108 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.184 HC variable region <400> 2108 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2109 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.185 LC variable region <400> 2109 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2110 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.185 HC variable region <400> 2110 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2111 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.186 LC variable region <400> 2111 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2112 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.186 HC variable region <400> 2112 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2113 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.187 LC variable region <400> 2113 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2114 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.187 HC variable region <400> 2114 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2115 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.188 LC variable region <400> 2115 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2116 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.188 HC variable region <400> 2116 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2117 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.189 LC variable region <400> 2117 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2118 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.189 HC variable region <400> 2118 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2119 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.190 LC variable region <400> 2119 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2120 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.190 HC variable region <400> 2120 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2121 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.191 LC variable region <400> 2121 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Arg 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2122 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.191 HC variable region <400> 2122 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2123 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.192 LC variable region <400> 2123 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2124 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.192 HC variable region <400> 2124 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Ser Phe Ala Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2125 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.193 LC variable region <400> 2125 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2126 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.193 HC variable region <400> 2126 Gln Ile Thr Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Ala Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2127 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.194 LC variable region <400> 2127 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2128 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.194 HC variable region <400> 2128 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Ser Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Gly Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2129 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.195 LC variable region <400> 2129 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asp Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2130 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> No.195 HC variable region <400> 2130 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Asn Phe Thr Arg Tyr 20 25 30 Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 50 55 60 Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 65 70 75 80 Leu Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Leu Gly Ile Ala Val Ala Gly Thr Pro Ile Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2131 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.196 LC variable region <400> 2131 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2132 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.196 HC variable region <400> 2132 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 2133 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.197 LC variable region <400> 2133 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2134 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.197 HC variable region <400> 2134 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Glu Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 2135 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.198 LC variable region <400> 2135 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Ala Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2136 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.198 HC variable region <400> 2136 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 2137 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.199 LC variable region <400> 2137 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2138 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.199 HC variable region <400> 2138 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Glu Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 2139 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.200 LC variable region <400> 2139 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2140 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.200 HC variable region <400> 2140 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Phe Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 2141 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.201 LC variable region <400> 2141 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2142 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.201 HC variable region <400> 2142 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 2143 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.202 LC variable region <400> 2143 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2144 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.202 HC variable region <400> 2144 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Val Arg Gly Tyr Ser Gly Tyr Gly Ser Thr Tyr Tyr Ser Asp 100 105 110 Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Ser 115 120 <210> 2145 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.203 LC variable region <400> 2145 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2146 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.203 HC variable region <400> 2146 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2147 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.204 LC variable region <400> 2147 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2148 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.204 HC variable region <400> 2148 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2149 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.205 LC variable region <400> 2149 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2150 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.205 HC variable region <400> 2150 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2151 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.206 LC variable region <400> 2151 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2152 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.206 HC variable region <400> 2152 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2153 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.207 LC variable region <400> 2153 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ala Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2154 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.207 HC variable region <400> 2154 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2155 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.208 LC variable region <400> 2155 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2156 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.208 HC variable region <400> 2156 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2157 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.209 LC variable region <400> 2157 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Ala Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2158 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.209 HC variable region <400> 2158 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2159 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.210 LC variable region <400> 2159 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2160 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.210 HC variable region <400> 2160 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2161 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.211 LC variable region <400> 2161 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Gly Asn 20 25 30 Thr Val Asn Trp Phe Gln Gln Leu Pro Gly Ala Val Pro Lys Leu Leu 35 40 45 Val Tyr Gly Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2162 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.211 HC variable region <400> 2162 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2163 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.212 LC variable region <400> 2163 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Glu Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2164 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.212 HC variable region <400> 2164 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Arg Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2165 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.213 LC variable region <400> 2165 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2166 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.213 HC variable region <400> 2166 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2167 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.214 LC variable region <400> 2167 Glu Leu Met Leu Thr Gln Pro His Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Thr Leu 85 90 95 Asp Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2168 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.214 HC variable region <400> 2168 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Pro Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2169 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.215 LC variable region <400> 2169 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2170 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.215 HC variable region <400> 2170 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2171 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.216 LC variable region <400> 2171 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2172 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.216 HC variable region <400> 2172 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2173 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.217 LC variable region <400> 2173 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Val Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2174 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.217 HC variable region <400> 2174 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2175 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.218 LC variable region <400> 2175 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Ser Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Ser Asn 20 25 30 Pro Val Asn Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asn Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2176 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.218 HC variable region <400> 2176 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2177 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.219 LC variable region <400> 2177 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Phe Pro Gly Ala Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Val Ser 50 55 60 Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Gly Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2178 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.219 HC variable region <400> 2178 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2179 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.220 LC variable region <400> 2179 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2180 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.220 HC variable region <400> 2180 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Pro Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2181 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.221 LC variable region <400> 2181 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2182 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.221 HC variable region <400> 2182 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2183 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.222 LC variable region <400> 2183 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ala Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2184 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.222 HC variable region <400> 2184 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2185 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.223 LC variable region <400> 2185 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2186 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.223 HC variable region <400> 2186 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2187 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.224 LC variable region <400> 2187 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2188 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.224 HC variable region <400> 2188 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2189 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.225 LC variable region <400> 2189 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2190 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.225 HC variable region <400> 2190 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2191 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.226 LC variable region <400> 2191 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2192 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.226 HC variable region <400> 2192 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Phe Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2193 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.227 LC variable region <400> 2193 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2194 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.227 HC variable region <400> 2194 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2195 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.228 LC variable region <400> 2195 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Leu Ser Cys Ser Gly Ser Ser Ser Asn Val Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2196 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.228 HC variable region <400> 2196 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2197 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.229 LC variable region <400> 2197 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2198 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.229 HC variable region <400> 2198 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2199 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.230 LC variable region <400> 2199 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2200 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.230 HC variable region <400> 2200 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2201 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.231 LC variable region <400> 2201 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2202 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.231 HC variable region <400> 2202 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2203 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.232 LC variable region <400> 2203 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2204 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.232 HC variable region <400> 2204 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2205 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.233 LC variable region <400> 2205 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2206 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.233 HC variable region <400> 2206 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2207 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.234 LC variable region <400> 2207 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2208 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.234 HC variable region <400> 2208 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2209 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.235 LC variable region <400> 2209 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2210 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.235 HC variable region <400> 2210 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Phe Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2211 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.236 LC variable region <400> 2211 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Asn Ser 85 90 95 Glu Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2212 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.236 HC variable region <400> 2212 Glu Val Gln Leu Leu Glu Ser Arg Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2213 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.237 LC variable region <400> 2213 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2214 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.237 HC variable region <400> 2214 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2215 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.238 LC variable region <400> 2215 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2216 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.238 HC variable region <400> 2216 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2217 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.239 LC variable region <400> 2217 Asp Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Met Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2218 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.239 HC variable region <400> 2218 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2219 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.240 LC variable region <400> 2219 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2220 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.240 HC variable region <400> 2220 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Pro Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2221 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.241 LC variable region <400> 2221 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ile Asn 20 25 30 Ser Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Leu Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2222 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.241 HC variable region <400> 2222 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2223 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.242 LC variable region <400> 2223 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 20 25 30 Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2224 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.242 HC variable region <400> 2224 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Glu Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2225 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.243 LC variable region <400> 2225 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2226 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.243 HC variable region <400> 2226 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2227 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.244 LC variable region <400> 2227 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2228 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.244 HC variable region <400> 2228 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2229 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.245 LC variable region <400> 2229 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2230 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.245 HC variable region <400> 2230 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2231 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.246 LC variable region <400> 2231 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 85 90 95 Asn Gly Tyr Val Phe Gly Pro Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2232 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.246 HC variable region <400> 2232 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2233 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.247 LC variable region <400> 2233 Glu Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly 50 55 60 Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser 65 70 75 80 Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser 85 90 95 Gly Trp Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 <210> 2234 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.247 HC variable region <400> 2234 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2235 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.248 LC variable region <400> 2235 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2236 <211> 128 <212> PRT <213> Artificial Sequence <220> <223> No.248 HC variable region <400> 2236 Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Val Gly Val Gly Trp Ile Arg Gln Pro Gly Lys Ala Leu Glu 35 40 45 Trp Leu Thr Leu Ile Asp Trp Asp Asp Asn Lys Tyr Tyr Thr Thr Ser 50 55 60 Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 85 90 95 Cys Ala Arg Ile Pro Gly Phe Leu Arg Tyr Arg Asn Arg Tyr Tyr Tyr 100 105 110 Tyr Gly Met Asp Val Trp Gly Gly Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 2237 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.249 LC variable region <400> 2237 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Gly Ser Ser Asp His 85 90 95 Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 <210> 2238 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.249 HC variable region <400> 2238 Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 1 5 10 15 Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 35 40 45 Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Lys Leu Ser His Gly Val Val Gly Ala Gln Asp Ala Phe Asp Ile Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 <210> 2239 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.250 LC variable region <400> 2239 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2240 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> No.250 HC variable region <400> 2240 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2241 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.251 LC variable region <400> 2241 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2242 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.251 HC variable region <400> 2242 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2243 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.252 LC variable region <400> 2243 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2244 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.252 HC variable region <400> 2244 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2245 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.253 LC variable region <400> 2245 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2246 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.253 HC variable region <400> 2246 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2247 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.254 LC variable region <400> 2247 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 85 90 95 Pro Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 <210> 2248 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.254 HC variable region <400> 2248 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2249 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> No.255 LC variable region <400> 2249 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asn His Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 100 105 110 <210> 2250 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.255 HC variable region <400> 2250 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2251 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.256 LC variable region <400> 2251 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2252 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.256 HC variable region <400> 2252 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2253 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.257 LC variable region <400> 2253 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2254 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.257 HC variable region <400> 2254 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2255 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.258 LC variable region <400> 2255 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2256 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.258 HC variable region <400> 2256 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2257 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.259 LC variable region <400> 2257 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2258 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.259 HC variable region <400> 2258 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2259 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.260 LC variable region <400> 2259 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Asn Gly Leu Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 100 105 110 <210> 2260 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.260 HC variable region <400> 2260 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Ile Val Ser Ser 115 120 <210> 2261 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.261 LC variable region <400> 2261 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2262 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.261 HC variable region <400> 2262 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2263 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.262 LC variable region <400> 2263 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 85 90 95 Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2264 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.262 HC variable region <400> 2264 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2265 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.263 LC variable region <400> 2265 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Pro Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2266 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.263 HC variable region <400> 2266 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2267 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.264 LC variable region <400> 2267 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2268 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.264 HC variable region <400> 2268 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Thr Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Trp Asn Ser Gly Leu Ile Gly Tyr Ala Asp Ala Val 50 55 60 Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ser Ile Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Val Lys Asp Met Gly Ser Thr Gly Gly Tyr Tyr Gly Met Asp Val Trp 100 105 110 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 2269 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.265 LC variable region <400> 2269 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2270 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.265 HC variable region <400> 2270 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2271 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.266 LC variable region <400> 2271 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 50 55 60 Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Gln Val Arg Asp Ser Ser Ser Asp His 85 90 95 Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 2272 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.266 HC variable region <400> 2272 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2273 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.267 LC variable region <400> 2273 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2274 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.267 HC variable region <400> 2274 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2275 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.268 LC variable region <400> 2275 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Asp Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Asn Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Gln Ser Ser Asp Ser Gly 85 90 95 Leu Thr Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2276 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.268 HC variable region <400> 2276 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2277 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.269 LC variable region <400> 2277 Glu Leu Val Val Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu Arg 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ala Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2278 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> No.269 HC variable region <400> 2278 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Val Ser Tyr Asp Gly Ser Asn Asn Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Asp Tyr Tyr Gly Ser Gly Ser Tyr Tyr Asn Pro Ser Pro 100 105 110 Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2279 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.270 LC variable region <400> 2279 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2280 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.270 HC variable region <400> 2280 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2281 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.271 LC variable region <400> 2281 Glu Leu Glu Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Asn 85 90 95 Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> 2282 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.271 HC variable region <400> 2282 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2283 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.272 LC variable region <400> 2283 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2284 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.272 HC variable region <400> 2284 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2285 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.273 LC variable region <400> 2285 Glu Leu Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2286 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.273 HC variable region <400> 2286 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2287 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.274 LC variable region <400> 2287 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2288 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.274 HC variable region <400> 2288 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2289 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.275 LC variable region <400> 2289 Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 1 5 10 15 Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Asn Thr Val 20 25 30 Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 35 40 45 Ser Asn Asn Leu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 50 55 60 Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu 65 70 75 80 Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly 85 90 95 Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 2290 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.275 HC variable region <400> 2290 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2291 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> No.276 LC variable region <400> 2291 Glu Leu Glu Leu Thr Gln Pro Ser Ala Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Ser 20 25 30 Asp Val Gly Trp Tyr Gln His Leu Pro Gly Met Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Lys Ser Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Leu 85 90 95 Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 <210> 2292 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.276 HC variable region <400> 2292 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2293 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.277 LC variable region <400> 2293 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2294 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.277 HC variable region <400> 2294 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2295 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.278 LC variable region <400> 2295 Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Gly Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Phe Pro Phe 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2296 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.278 HC variable region <400> 2296 Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2297 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> No.279 LC variable region <400> 2297 Glu Leu Thr Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Pro 85 90 95 Thr Phe Gly Gin Gly Thr Arg Leu Glu Ile Lys 100 105 <210> 2298 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> No.279 HC variable region <400> 2298 Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Gly Ile Ala Pro Tyr Thr Arg Gly Ala Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2299 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.280 LC variable region <400> 2299 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Thr Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Asn Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2300 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.280 HC variable region <400> 2300 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Ile Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2301 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.281 LC variable region <400> 2301 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2302 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.281 HC variable region <400> 2302 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Ile Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2303 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.282 LC variable region <400> 2303 Glu Leu Val Leu Thr Gln Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 65 70 75 80 Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 85 90 95 Leu Asn Gly Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2304 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.282 HC variable region <400> 2304 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Ile Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2305 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> No.283 LC variable region <400> 2305 Glu Leu Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Pro 85 90 95 Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 100 105 <210> 2306 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> No.283 HC variable region <400> 2306 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 2307 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.284 LC variable region <400> 2307 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Gly Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2308 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> No.284 HC variable region <400> 2308 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Val Ser Ser Asn 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg His Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly His Val Asp Ile Pro Tyr Gly Met Asp Val Trp Gly Gln Gly 100 105 110 Thr Thr Val Thr Val Ser Ser 115 <210> 2309 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.285 LC variable region <400> 2309 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2310 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.285 HC variable region <400> 2310 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp 100 105 110 Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2311 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.286 LC variable region <400> 2311 Glu Leu Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2312 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> No.286 HC variable region <400> 2312 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Lys Gly Tyr Ser Gly Ser Gly Ser Val Asn Trp Phe Asp 100 105 110 Pro Trp Gly Gln Gly Thr Leu Val Thr Val Pro Ser 115 120 <210> 2313 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.287 LC variable region <400> 2313 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 100 105 110 <210> 2314 <211> 123 <212> PRT <213> Artificial Sequence <220> <223> No.287 HC variable region <400> 2314 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Glu Ala Thr Thr Gly Ile Asn Thr Asn Trp Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 2315 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.288 LC variable region <400> 2315 Glu Leu Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 85 90 95 Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 2316 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No.288 HC variable region <400> 2316 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ala Asn Leu Gly Tyr Cys Thr Asn Gly Val Cys Ala Pro Ser 100 105 110 Gly Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 125 <210> 2317 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> No.289 LC variable region <400> 2317 Glu Leu Val Leu Thr Gln Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Lys Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Asn Asn 20 25 30 Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 65 70 75 80 Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2318 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> No.289 HC variable region <400> 2318 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Lys Asn Leu Arg Tyr Phe Asp Trp Leu Leu Gly Asp Asp Ala Phe 100 105 110 Asp Ile Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser 115 120 125 <210> 2319 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> No.290 LC variable region <400> 2319 Glu Leu Glu Leu Thr Gln Pro Ser Val Ser Gly Ala Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 20 25 30 Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 85 90 95 Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 2320 <211> 117 <212> PRT <213> Artificial Sequence <220> <223> No.290 HC variable region <400> 2320 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 20 25 30 Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Leu Val Val Tyr Gly Met Asp Val Trp Gly Gin Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 <210> 2321 <211> 1273 <212> PRT <213> Artificial Sequence <220> <223> SARS-CoV-2 virus spike protein sequence <400> 2321 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 1010 1015 1020 Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 1025 1030 1035 1040 Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 1045 1050 1055 Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 1060 1065 1070 Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 1075 1080 1085 Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 1090 1095 1100 Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 1105 1110 1115 1120 Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 1125 1130 1135 Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 1140 1145 1150 Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 1155 1160 1165 Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 1170 1175 1180 Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 1185 1190 1195 1200 Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 1205 1210 1215 Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 1220 1225 1230 Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 1235 1240 1245 Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 1250 1255 1260 Leu Lys Gly Val Lys Leu His Tyr Thr 1265 1270

Claims (38)

사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질(Spike protein, S protein)의 RBD(Receptor Binding Domain) 내 에피토프에 결합하는 사스-코로나바이러스-2 중화 결합 분자로서,
상기 결합 분자의 에피토프는
사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 417, 449, 453, 455, 456, 484, 486, 489, 490, 493, 496 및 505로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 잔기(residue)를 포함하는, 결합 분자.As a SARS-coronavirus-2 neutralizing binding molecule that binds to an epitope in the Receptor Binding Domain (RBD) of the spike protein (S protein) of SARS-CoV-2,
The epitope of the binding molecule is
comprising at least one amino acid residue selected from the group consisting of amino acid positions 417, 449, 453, 455, 456, 484, 486, 489, 490, 493, 496 and 505 of the SARS-coronavirus-2 spike protein which is a binding molecule. 제1항에 있어서,
상기 결합 분자의 에피토프는
사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 403, 450, 452, 483, 485, 492, 494 및 495로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 잔기를 추가로 포함함을 특징으로 하는, 결합 분자.The method of claim 1,
The epitope of the binding molecule is
A binding molecule, characterized in that it further comprises one or more amino acid residues selected from the group consisting of amino acid positions 403, 450, 452, 483, 485, 492, 494 and 495 of the spike protein of SARS-coronavirus-2. 제1항에 있어서,
상기 결합 분자의 에피토프는
사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 449, 455, 456, 484, 486, 489, 490 및 493의 아미노산 잔기(residue)를 포함함을 특징으로 하는, 결합 분자.The method of claim 1,
The epitope of the binding molecule is
A binding molecule comprising amino acid residues at amino acid positions 449, 455, 456, 484, 486, 489, 490 and 493 of the spike protein of SARS-coronavirus-2. 제3항에 있어서,
상기 결합 분자의 에피토프는
사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 450, 452, 485, 492 및 494의 아미노산 잔기(residue)를 추가로 포함함을 특징으로 하는, 결합 분자.4. The method of claim 3,
The epitope of the binding molecule is
A binding molecule, characterized in that it further comprises amino acid residues at amino acid positions 450, 452, 485, 492 and 494 of the spike protein of SARS-coronavirus-2. 제1항에 있어서,
상기 결합 분자의 에피토프는
사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 417, 449, 453, 455, 456, 484, 486, 489, 490, 493, 496 및 505의 아미노산 잔기(residue)를 포함함을 특징으로 하는, 결합 분자.According to claim 1,
The epitope of the binding molecule is
A binding, characterized in that it comprises amino acid residues at amino acid positions 417, 449, 453, 455, 456, 484, 486, 489, 490, 493, 496 and 505 of the spike protein of SARS-coronavirus-2 molecule. 제5항에 있어서,
상기 결합 분자의 에피토프는
사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 403, 450, 452, 483, 485, 492, 494 및 495의 아미노산 잔기를 추가로 포함함을 특징으로 하는, 결합 분자.6. The method of claim 5,
The epitope of the binding molecule is
A binding molecule, characterized in that it further comprises amino acid residues at amino acid positions 403, 450, 452, 483, 485, 492, 494 and 495 of the spike protein of SARS-coronavirus-2. 제1항 내지 제6항 중 어느 한 항에 있어서,
상기 결합 분자의 에피토프는 구조 에피토프(conformational epitope)임을 특징으로 하는 결합 분자.7. The method according to any one of claims 1 to 6,
Binding molecule, characterized in that the epitope of the binding molecule is a conformational epitope. 제1항 내지 제6항 중 어느 한 항에 있어서,
상기 결합 분자는 1x10-8 M 이하의 결합 친화도(KD)를 가짐을 특징으로 하는 결합 분자.7. The method according to any one of claims 1 to 6,
The binding molecule, characterized in that it has a binding affinity (K D ) of 1x10 -8 M or less. 제1항 내지 제6항 중 어느 한 항에 있어서,
상기 결합분자는 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질의 RBD(Receptor Binding Domain)와 표적 세포의 ACE2(Angiotensin-converting enzyme 2) 수용체의 결합을 억제함을 특징으로 하는 결합 분자.7. The method according to any one of claims 1 to 6,
The binding molecule is SARS-coronavirus-2 (SARS-CoV-2) of the spike protein RBD (Receptor Binding Domain) and ACE2 (Angiotensin-converting enzyme 2) of the target cell binding characterized in that it inhibits the receptor molecule. 제3항 또는 제4항에 있어서,
상기 결합 분자는 표 1의 결합 분자 No. 89 내지 No. 194, 및 No. 248로 이루어진 군으로부터 선택되는 어느 하나임을 특징으로 하는, 결합 분자.5. The method according to claim 3 or 4,
The binding molecule is the binding molecule No. in Table 1. 89 to No. 194, and No. 248, the binding molecule, characterized in that any one selected from the group consisting of. 제3항 또는 제4항에 있어서,
상기 결합 분자는 표 2의 결합 분자 No. 89 내지 No. 194, 및 No. 248로 이루어진 군으로부터 선택되는 어느 하나임을 특징으로 하는, 결합 분자.5. The method according to claim 3 or 4,
The binding molecule is the binding molecule No. in Table 2. 89 to No. 194, and No. 248, the binding molecule, characterized in that any one selected from the group consisting of. 제6항에 있어서,
상기 결합 분자는 표 1의 결합 분자 No. 89 내지 No. 127, No. 129 내지 No. 194, 및 No. 248로 이루어진 군으로부터 선택되는 어느 하나임을 특징으로 하는, 결합 분자.7. The method of claim 6,
The binding molecule is the binding molecule No. in Table 1. 89 to No. 127, No. 129 to No. 194, and No. 248, the binding molecule, characterized in that any one selected from the group consisting of. 제6항에 있어서,
상기 결합 분자는 표 2의 결합 분자 No. 89 내지 No. 127, No. 129 내지 No. 194, 및 No. 248로 이루어진 군으로부터 선택되는 어느 하나임을 특징으로 하는, 결합 분자.7. The method of claim 6,
The binding molecule is the binding molecule No. in Table 2. 89 to No. 127, No. 129 to No. 194, and No. 248, the binding molecule, characterized in that any one selected from the group consisting of. 제1항 내지 제6항 중 어느 한 항에 있어서,
상기 결합 분자는 사스-코로나바이러스-2의 스파이크 단백질의 RBD의 결합에 표 1의 결합 분자로 이루어진 군으로부터 선택되는 어느 하나의 결합 분자와 경쟁함을 특징으로 하는, 결합 분자.7. The method according to any one of claims 1 to 6,
The binding molecule is characterized in that it competes with any one binding molecule selected from the group consisting of the binding molecules of Table 1 for binding of the RBD of the SARS-coronavirus-2 spike protein. 제1항 내지 제6항 중 어느 한 항에 있어서,
상기 결합 분자는 사스-코로나바이러스-2의 스파이크 단백질의 RBD의 결합에 표 2의 결합 분자로 이루어진 군으로부터 선택되는 어느 하나의 결합 분자와 경쟁함을 특징으로 하는, 결합 분자.7. The method according to any one of claims 1 to 6,
The binding molecule is characterized in that it competes with any one binding molecule selected from the group consisting of the binding molecules of Table 2 for binding of the RBD of the SARS-coronavirus-2 spike protein. 제1항 내지 제6항 중 어느 한 항에 있어서,
상기 결합 분자는
서열번호: 829의 CDR1 영역, 서열번호: 830의 CDR2 영역, 및 서열번호: 831의 CDR3 영역을 포함하는 경쇄 가변영역; 및
서열번호: 832의 CDR1 영역, 서열번호: 833의 CDR2 영역, 및 서열번호: 834의 CDR3 영역을 포함하는 중쇄 가변영역
포함함을 특징으로 하는, 결합 분자.7. The method according to any one of claims 1 to 6,
The binding molecule is
a light chain variable region comprising the CDR1 region of SEQ ID NO: 829, the CDR2 region of SEQ ID NO: 830, and the CDR3 region of SEQ ID NO: 831; and
a heavy chain variable region comprising the CDR1 region of SEQ ID NO: 832, the CDR2 region of SEQ ID NO: 833, and the CDR3 region of SEQ ID NO: 834
A binding molecule, characterized in that it comprises. 제1항 내지 제6항 중 어느 한 항에 있어서,
상기 결합 분자는
서열번호: 2017의 폴리펩티드 서열의 경쇄 가변영역; 및
서열번호: 2018의 폴리펩티드 서열의 중쇄 가변영역
을 포함함을 특징으로 하는, 결합 분자.7. The method according to any one of claims 1 to 6,
The binding molecule is
light chain variable region of the polypeptide sequence of SEQ ID NO: 2017; and
SEQ ID NO: 2018 heavy chain variable region of the polypeptide sequence
A binding molecule comprising a. 제1항 내지 제6항 중 어느 한 항에 있어서,
상기 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질은 서열번호: 2321의 폴리펩티드 서열을 포함함을 특징으로 하는 결합 분자.7. The method according to any one of claims 1 to 6,
The SARS-coronavirus-2 (SARS-CoV-2) spike protein is a binding molecule comprising the polypeptide sequence of SEQ ID NO: 2321. 제1항 내지 제6항 중 어느 한 항에 있어서,
상기 결합 분자는 항체 또는 그것의 항원 결합 단편임을 특징으로 하는 결합 분자.7. The method according to any one of claims 1 to 6,
wherein the binding molecule is an antibody or antigen-binding fragment thereof. 제1항 내지 제6항 중 어느 한 항에 있어서,
상기 결합 분자는 scFv 절편, scFv-Fc 절편, Fab 절편, Fv 절편, 디아바디(diabody), 키메라 항체, 인간화 항체 또는 인간 항체임을 특징으로 하는, 결합 분자.7. The method according to any one of claims 1 to 6,
The binding molecule, characterized in that the scFv fragment, scFv-Fc fragment, Fab fragment, Fv fragment, diabody, chimeric antibody, humanized antibody or human antibody. 제1항 내지 제6항 중 어느 한 항에 있어서,
상기 결합 분자는 사스-코로나바이러스-2의 스파이크 단백질에 돌연변이가 생긴 변이 바이러스에 중화능이 있음을 특징으로 하는, 결합 분자.7. The method according to any one of claims 1 to 6,
The binding molecule is characterized in that it has neutralizing ability to a mutant virus in which the spike protein of SARS-coronavirus-2 is mutated. 제1항 내지 제6항 중 어느 한 항에 있어서,
상기 결합 분자는 사스-코로나바이러스-2의 스파이크 단백질의 RBD 영역 이외의 부위에 돌연변이가 생긴 변이 바이러스에 중화능이 있음을 특징으로 하는, 결합 분자.7. The method according to any one of claims 1 to 6,
The binding molecule is characterized in that it has neutralizing ability to a mutant virus having a mutation in a site other than the RBD region of the SARS-coronavirus-2 spike protein. 제1항 내지 제6항 중 어느 한 항에 있어서,
상기 결합 분자는 사스-코로나바이러스-2 S형, L형, V형, G형, GH형 또는 GR형에 중화능이 있음을 특징으로 하는, 결합 분자. 7. The method according to any one of claims 1 to 6,
The binding molecule is a SARS-coronavirus-2 type S, L, V, G, GH or GR type, characterized in that the neutralizing ability, the binding molecule. 제1항 내지 제6항 중 어느 한 항에 있어서,
상기 결합 분자는 하기 1) 내지 76)으로 이루어진 군으로부터 선택되는 어느 하나 이상의 변이 바이러스에 중화능이 있음을 특징으로 하는, 결합 분자:
1) 사스-코로나바이러스-2의 스파이크 단백질의 69번 및 70번 아미노산 위치 중 하나 이상이 결실된 변이 바이러스;
2) 사스-코로나바이러스-2의 스파이크 단백질의 80번 아미노산 위치에서 D80A 변이가 생긴 변이 바이러스;
3) 사스-코로나바이러스-2의 스파이크 단백질의 222번 아미노산 위치에서 A222V 변이가 생긴 변이 바이러스;
4) 사스-코로나바이러스-2의 스파이크 단백질의 234번 아미노산 위치에서 N234Q 변이가 생긴 변이 바이러스;
5) 사스-코로나바이러스-2의 스파이크 단백질의 337번 아미노산 위치에서 P337S 변이가 생긴 변이 바이러스;
6) 사스-코로나바이러스-2의 스파이크 단백질의 338번 아미노산 위치에서 F338L 변이가 생긴 변이 바이러스;
7) 사스-코로나바이러스-2의 스파이크 단백질의 348번 아미노산 위치에서 A348S 변이가 생긴 변이 바이러스;
8) 사스-코로나바이러스-2의 스파이크 단백질의 367번 아미노산 위치에서 V367F 변이가 생긴 변이 바이러스;
9) 사스-코로나바이러스-2의 스파이크 단백질의 370번 아미노산 위치에서 N370S 변이가 생긴 변이 바이러스;
10) 사스-코로나바이러스-2의 스파이크 단백질의 372번 아미노산 위치에서 A372S 변이, A372T 변이 또는 A372V 변이가 생긴 변이 바이러스;
11) 사스-코로나바이러스-2의 스파이크 단백질의 341번 아미노산 위치에서 V341I 변이가 생긴 변이 바이러스;
12) 사스-코로나바이러스-2의 스파이크 단백질의 342번 아미노산 위치에서 F342L 변이가 생긴 변이 바이러스;
13) 사스-코로나바이러스-2의 스파이크 단백질의 344번 아미노산 위치에서 A344S 변이가 생긴 변이 바이러스;
14) 사스-코로나바이러스-2의 스파이크 단백질의 352번 아미노산 위치에서 A352S 변이가 생긴 변이 바이러스;
15) 사스-코로나바이러스-2의 스파이크 단백질의 354번 아미노산 위치에서 N354D 변이가 생긴 변이 바이러스;
16) 사스-코로나바이러스-2의 스파이크 단백질의 359번 아미노산 위치에서 S359N 변이가 생긴 변이 바이러스;
17) 사스-코로나바이러스-2의 스파이크 단백질의 377번 아미노산 위치에서 F377L 변이가 생긴 변이 바이러스;
18) 사스-코로나바이러스-2의 스파이크 단백질의 378번 아미노산 위치에서 K378R 변이 또는 K378N 변이가 생긴 변이 바이러스;
19) 사스-코로나바이러스-2의 스파이크 단백질의 384번 아미노산 위치에서 P384L 변이가 생긴 변이 바이러스;
20) 사스-코로나바이러스-2의 스파이크 단백질의 385번 아미노산 위치에서 T385A 변이가 생긴 변이 바이러스;
21) 사스-코로나바이러스-2의 스파이크 단백질의 393번 아미노산 위치에서 T393P 변이가 생긴 변이 바이러스;
22) 사스-코로나바이러스-2의 스파이크 단백질의 395번 아미노산 위치에서 V395I 변이가 생긴 변이 바이러스;
23) 사스-코로나바이러스-2의 스파이크 단백질의 405번 아미노산 위치에서 D405V 변이가 생긴 변이 바이러스;
24) 사스-코로나바이러스-2의 스파이크 단백질의 406번 아미노산 위치에서 E406Q 변이 또는 E406W 변이가 생긴 변이 바이러스;
25) 사스-코로나바이러스-2의 스파이크 단백질의 408번 아미노산 위치에서 R408I 변이가 생긴 변이 바이러스;
26) 사스-코로나바이러스-2의 스파이크 단백질의 409번 아미노산 위치에서 Q409E 변이가 생긴 변이 바이러스;
27) 사스-코로나바이러스-2의 스파이크 단백질의 414번 아미노산 위치에서 Q414A 변이, Q414E 변이 또는 Q414R 변이가 생긴 변이 바이러스;
28) 사스-코로나바이러스-2의 스파이크 단백질의 417번 아미노산 위치에서 K417N 변이, K417T 변이 또는 K417E 변이가 생긴 변이 바이러스;
29) 사스-코로나바이러스-2의 스파이크 단백질의 420번 아미노산 위치에서 D420N 변이가 생긴 변이 바이러스;
30) 사스-코로나바이러스-2의 스파이크 단백질의 435번 아미노산 위치에서 A435S 변이가 생긴 변이 바이러스;
31) 사스-코로나바이러스-2의 스파이크 단백질의 436번 아미노산 위치에서 W436R 변이가 생긴 변이 바이러스;
32) 사스-코로나바이러스-2의 스파이크 단백질의 439번 아미노산 위치에서 N439K 변이가 생긴 변이 바이러스;
33) 사스-코로나바이러스-2의 스파이크 단백질의 440번 아미노산 위치에서 N440K 변이 또는 N440D 변이가 생긴 변이 바이러스;
34) 사스-코로나바이러스-2의 스파이크 단백질의 444번 아미노산 위치에서 K444Q 변이 또는 K444R 변이가 생긴 변이 바이러스;
35) 사스-코로나바이러스-2의 스파이크 단백질의 445번 아미노산 위치에서 V445A 변이 또는 V445F 변이가 생긴 변이 바이러스;
36) 사스-코로나바이러스-2의 스파이크 단백질의 446번 아미노산 위치에서 G446V 변이 또는 G446S 변이가 생긴 변이 바이러스;
37) 사스-코로나바이러스-2의 스파이크 단백질의 449번 아미노산 위치에서 Y449N 변이가 생긴 변이 바이러스;
38) 사스-코로나바이러스-2의 스파이크 단백질의 452번 아미노산 위치에서 L452R 변이가 생긴 변이 바이러스;
39) 사스-코로나바이러스-2의 스파이크 단백질의 453번 아미노산 위치에서 Y453F 변이가 생긴 변이 바이러스;
40) 사스-코로나바이러스-2의 스파이크 단백질의 455번 아미노산 위치에서 L455F 변이가 생긴 변이 바이러스;
41) 사스-코로나바이러스-2의 스파이크 단백질의 456번 아미노산 위치에서 F456L 변이 또는 F456E 변이가 생긴 변이 바이러스;
42) 사스-코로나바이러스-2의 스파이크 단백질의 458번 아미노산 위치에서 K458R 변이 또는 K458Q 변이가 생긴 변이 바이러스;
43) 사스-코로나바이러스-2의 스파이크 단백질의 460번 아미노산 위치에서 N460T 변이가 생긴 변이 바이러스;
44) 사스-코로나바이러스-2의 스파이크 단백질의 471번 아미노산 위치에서 E471Q 변이가 생긴 변이 바이러스;
45) 사스-코로나바이러스-2의 스파이크 단백질의 472번 아미노산 위치에서 I472V 변이가 생긴 변이 바이러스;
46) 사스-코로나바이러스-2의 스파이크 단백질의 473번 아미노산 위치에서 Y473F 변이가 생긴 변이 바이러스;
47) 사스-코로나바이러스-2의 스파이크 단백질의 475번 아미노산 위치에서 A475V 변이가 생긴 변이 바이러스;
48) 사스-코로나바이러스-2의 스파이크 단백질의 476번 아미노산 위치에서 G476S 변이가 생긴 변이 바이러스;
49) 사스-코로나바이러스-2의 스파이크 단백질의 477번 아미노산 위치에서 S477N 변이, S477R 변이, S477I 변이 또는 S477R 변이가 생긴 변이 바이러스;
50) 사스-코로나바이러스-2의 스파이크 단백질의 478번 아미노산 위치에서 T478K 변이 또는 T478I 변이가 생긴 변이 바이러스;
51) 사스-코로나바이러스-2의 스파이크 단백질의 479번 아미노산 위치에서 P479S 변이가 생긴 변이 바이러스;
52) 사스-코로나바이러스-2의 스파이크 단백질의 481번 아미노산 위치에서 N481D 변이가 생긴 변이 바이러스;
53) 사스-코로나바이러스-2의 스파이크 단백질의 482번 아미노산 위치에서 G482S 변이가 생긴 변이 바이러스;
54) 사스-코로나바이러스-2의 스파이크 단백질의 483번 아미노산 위치에서 V483A 변이 또는 V483I 변이가 생긴 변이 바이러스;
55) 사스-코로나바이러스-2의 스파이크 단백질의 484번 아미노산 위치에서 E484K 변이, E484G 변이 또는 E484Q 변이가 생긴 변이 바이러스;
56) 사스-코로나바이러스-2의 스파이크 단백질의 485번 아미노산 위치에서 G485S변이가 생긴 변이 바이러스;
57) 사스-코로나바이러스-2의 스파이크 단백질의 486번 아미노산 위치에서 F486S 변이, F486L 변이, F486V 변이 또는 F486I 변이가 생긴 변이 바이러스;
58) 사스-코로나바이러스-2의 스파이크 단백질의 489번 아미노산 위치에서 Y489H 변이가 생긴 변이 바이러스;
59) 사스-코로나바이러스-2의 스파이크 단백질의 490번 아미노산 위치에서 F490S 변이가 생긴 변이 바이러스;
60) 사스-코로나바이러스-2의 스파이크 단백질의 493번 아미노산 위치에서 Q493K 변이, Q493R 변이, Q493M 변이, Q493Y 변이 또는 Q493A 변이가 생긴 변이 바이러스;
61) 사스-코로나바이러스-2의 스파이크 단백질의 494번 아미노산 위치에서 S494Q 변이, S494L 변이 또는 S494P 변이가 생긴 변이 바이러스;
62) 사스-코로나바이러스-2의 스파이크 단백질의 498번 아미노산 위치에서 Q498H 변이가 생긴 변이 바이러스;
63) 사스-코로나바이러스-2의 스파이크 단백질의 499번 아미노산 위치에서 P499R 변이가 생긴 변이 바이러스;
64) 사스-코로나바이러스-2의 스파이크 단백질의 501번 아미노산 위치에서 N501Y 변이, N501T 변이 또는 N501F 변이가 생긴 변이 바이러스;
65) 사스-코로나바이러스-2의 스파이크 단백질의 503번 아미노산 위치에서 V503F 변이가 생긴 변이 바이러스;
66) 사스-코로나바이러스-2의 스파이크 단백질의 505번 아미노산 위치에서 Y505C 변이가 생긴 변이 바이러스;
67) 사스-코로나바이러스-2의 스파이크 단백질의 508번 아미노산 위치에서 Y508H 변이가 생긴 변이 바이러스;
68) 사스-코로나바이러스-2의 스파이크 단백질의 520번 아미노산 위치에서 A520S 변이 또는 A520V 변이가 생긴 변이 바이러스;
69) 사스-코로나바이러스-2의 스파이크 단백질의 521번 아미노산 위치에서 P521R 변이 또는 P521S 변이가 생긴 변이 바이러스;
70) 사스-코로나바이러스-2의 스파이크 단백질의 522번 아미노산 위치에서 A522S 변이 또는 A522V 변이가 생긴 변이 바이러스;
71) 사스-코로나바이러스-2의 스파이크 단백질의 614번 아미노산 위치에서 D614G 변이가 생긴 변이 바이러스;
72) 사스-코로나바이러스-2의 스파이크 단백질의 677번 아미노산 위치에서 Q677H 변이가 생긴 변이 바이러스;
73) 사스-코로나바이러스-2의 스파이크 단백질의 681번 아미노산 위치에서 P681H 변이 또는 P681R 변이가 생긴 변이 바이러스;
74) 사스-코로나바이러스-2의 스파이크 단백질의 685번 아미노산 위치에서 R685H 변이가 생긴 변이 바이러스;
75) 사스-코로나바이러스-2의 스파이크 단백질의 701번 아미노산 위치에서 A701V 변이가 생긴 변이 바이러스;
및
76) 사스-코로나바이러스-2의 스파이크 단백질의 1176번 아미노산 위치에서 V1176F 변이가 생긴 변이 바이러스.7. The method according to any one of claims 1 to 6,
The binding molecule is a binding molecule, characterized in that it has neutralizing ability to any one or more mutant viruses selected from the group consisting of the following 1) to 76):
1) a mutant virus in which at least one of amino acid positions 69 and 70 of the spike protein of SARS-coronavirus-2 is deleted;
2) SARS-Coronavirus-2 mutant virus with D80A mutation at amino acid position 80 of the spike protein;
3) a mutant virus with A222V mutation at amino acid position 222 of the spike protein of SARS-coronavirus-2;
4) a mutant virus with N234Q mutation at amino acid position 234 of the SARS-coronavirus-2 spike protein;
5) SARS-Coronavirus-2 mutant virus with P337S mutation at amino acid position 337 of the spike protein;
6) a mutant virus with F338L mutation at amino acid position 338 of the SARS-coronavirus-2 spike protein;
7) a mutant virus with A348S mutation at amino acid position 348 of the SARS-coronavirus-2 spike protein;
8) SARS-Coronavirus-2 mutant virus with V367F mutation at amino acid position 367 of the spike protein;
9) SARS-Coronavirus-2 mutant virus with N370S mutation at amino acid position 370 of the spike protein;
10) a mutant virus having A372S mutation, A372T mutation or A372V mutation at amino acid position 372 of the SARS-coronavirus-2 spike protein;
11) a mutant virus with V341I mutation at amino acid position 341 of the SARS-coronavirus-2 spike protein;
12) a mutant virus in which F342L mutation occurred at amino acid position 342 of the SARS-coronavirus-2 spike protein;
13) SARS-Coronavirus-2 mutant virus with A344S mutation at amino acid position 344 of the spike protein;
14) a mutant virus having an A352S mutation at amino acid position 352 of the SARS-coronavirus-2 spike protein;
15) a mutant virus with N354D mutation at amino acid position 354 of the SARS-coronavirus-2 spike protein;
16) a mutant virus with S359N mutation at amino acid position 359 of the SARS-coronavirus-2 spike protein;
17) a mutant virus with F377L mutation at amino acid position 377 of the SARS-coronavirus-2 spike protein;
18) SARS-coronavirus-2 mutant virus in which K378R mutation or K378N mutation occurs at amino acid position 378 of the spike protein;
19) SARS-Coronavirus-2 mutant virus with P384L mutation at amino acid position 384 of the spike protein;
20) a mutant virus with T385A mutation at amino acid position 385 of the SARS-coronavirus-2 spike protein;
21) a mutant virus having T393P mutation at amino acid position 393 of the SARS-coronavirus-2 spike protein;
22) a mutant virus with V395I mutation at amino acid position 395 of the SARS-coronavirus-2 spike protein;
23) a mutant virus in which D405V mutation occurred at amino acid position 405 of the SARS-coronavirus-2 spike protein;
24) a mutant virus having E406Q mutation or E406W mutation at amino acid position 406 of the SARS-coronavirus-2 spike protein;
25) SARS-coronavirus-2 mutant virus with R408I mutation at amino acid position 408 of the spike protein;
26) a mutant virus having Q409E mutation at amino acid position 409 of the SARS-coronavirus-2 spike protein;
27) a mutant virus having Q414A mutation, Q414E mutation, or Q414R mutation at amino acid position 414 of the SARS-coronavirus-2 spike protein;
28) a mutant virus in which K417N mutation, K417T mutation or K417E mutation occurs at amino acid position 417 of the SARS-coronavirus-2 spike protein;
29) SARS-Coronavirus-2 mutant virus with D420N mutation at amino acid position 420 of the spike protein;
30) SARS-Coronavirus-2 mutant virus with A435S mutation at amino acid position 435 of the spike protein;
31) SARS-coronavirus-2 mutant virus in which W436R mutation occurred at amino acid position 436 of the spike protein;
32) a mutant virus with N439K mutation at amino acid position 439 of the SARS-coronavirus-2 spike protein;
33) SARS-coronavirus-2 mutant virus in which N440K mutation or N440D mutation occurs at amino acid position 440 of the spike protein;
34) a mutant virus in which K444Q mutation or K444R mutation occurs at amino acid position 444 of the SARS-coronavirus-2 spike protein;
35) SARS-coronavirus-2 mutant virus in which V445A mutation or V445F mutation occurs at amino acid position 445 of the spike protein;
36) SARS-Coronavirus-2, a mutant virus having G446V mutation or G446S mutation at amino acid position 446 of the spike protein;
37) a mutant virus with Y449N mutation at amino acid position 449 of the SARS-coronavirus-2 spike protein;
38) SARS-Coronavirus-2 mutant virus with L452R mutation at amino acid position 452 of the spike protein;
39) a mutant virus in which Y453F mutation occurs at amino acid position 453 of the SARS-coronavirus-2 spike protein;
40) SARS-Coronavirus-2 mutant virus with L455F mutation at amino acid position 455 of the spike protein;
41) a mutant virus having F456L mutation or F456E mutation at amino acid position 456 of the SARS-coronavirus-2 spike protein;
42) a mutant virus having K458R mutation or K458Q mutation at amino acid position 458 of the SARS-coronavirus-2 spike protein;
43) SARS-Coronavirus-2 mutant virus with N460T mutation at amino acid position 460 of the spike protein;
44) SARS-coronavirus-2 mutant virus with E471Q mutation at amino acid position 471 of the spike protein;
45) SARS-coronavirus-2 mutant virus with I472V mutation at amino acid position 472 of the spike protein;
46) a mutant virus in which a Y473F mutation occurred at amino acid position 473 of the SARS-coronavirus-2 spike protein;
47) a mutant virus having A475V mutation at amino acid position 475 of the SARS-coronavirus-2 spike protein;
48) a mutant virus in which a G476S mutation occurred at amino acid position 476 of the SARS-coronavirus-2 spike protein;
49) S477N mutation, S477R mutation, S477I mutation or S477R mutation at amino acid position 477 of the spike protein of SARS-coronavirus-2;
50) SARS-Coronavirus-2 mutant virus in which T478K mutation or T478I mutation occurs at amino acid position 478 of the spike protein;
51) SARS-coronavirus-2 mutant virus with P479S mutation at amino acid position 479 of the spike protein;
52) SARS-Coronavirus-2 mutant virus with N481D mutation at amino acid position 481 of the spike protein;
53) SARS-Coronavirus-2 mutant virus in which G482S mutation occurred at amino acid position 482 of the spike protein;
54) a mutant virus having V483A mutation or V483I mutation at amino acid position 483 of the SARS-coronavirus-2 spike protein;
55) a mutant virus having E484K mutation, E484G mutation or E484Q mutation at amino acid position 484 of the SARS-coronavirus-2 spike protein;
56) SARS-Coronavirus-2 mutant virus with G485S mutation at amino acid position 485 of the spike protein;
57) a mutant virus having F486S mutation, F486L mutation, F486V mutation or F486I mutation at amino acid position 486 of the SARS-coronavirus-2 spike protein;
58) SARS-coronavirus-2 mutant virus in which Y489H mutation occurred at amino acid position 489 of the spike protein;
59) SARS-coronavirus-2 mutant virus with F490S mutation at amino acid position 490 of the spike protein;
60) a mutant virus having Q493K mutation, Q493R mutation, Q493M mutation, Q493Y mutation or Q493A mutation at amino acid position 493 of the SARS-coronavirus-2 spike protein;
61) SARS-Coronavirus-2 mutant virus having S494Q mutation, S494L mutation or S494P mutation at amino acid position 494 of the spike protein;
62) a mutant virus in which a Q498H mutation occurred at amino acid position 498 of the SARS-coronavirus-2 spike protein;
63) SARS-coronavirus-2 mutant virus with P499R mutation at amino acid position 499 of the spike protein;
64) a mutant virus having N501Y mutation, N501T mutation or N501F mutation at amino acid position 501 of the SARS-coronavirus-2 spike protein;
65) a mutant virus in which V503F mutation occurred at amino acid position 503 of the SARS-coronavirus-2 spike protein;
66) a mutant virus with Y505C mutation at amino acid position 505 of the SARS-coronavirus-2 spike protein;
67) a mutant virus with Y508H mutation at amino acid position 508 of the SARS-coronavirus-2 spike protein;
68) SARS-Coronavirus-2 mutant virus with A520S mutation or A520V mutation at amino acid position 520 of the spike protein;
69) SARS-Coronavirus-2, a mutant virus having P521R mutation or P521S mutation at amino acid position 521 of the spike protein;
70) a mutant virus having A522S mutation or A522V mutation at amino acid position 522 of the SARS-coronavirus-2 spike protein;
71) SARS-Coronavirus-2 mutant virus with D614G mutation at amino acid position 614 of the spike protein;
72) a mutant virus with Q677H mutation at amino acid position 677 of the SARS-coronavirus-2 spike protein;
73) a mutant virus in which P681H mutation or P681R mutation occurs at amino acid position 681 of the SARS-coronavirus-2 spike protein;
74) SARS-coronavirus-2 mutant virus with R685H mutation at amino acid position 685 of the spike protein;
75) a mutant virus having A701V mutation at amino acid position 701 of the SARS-coronavirus-2 spike protein;
and
76) A mutant virus with V1176F mutation at amino acid position 1176 of the SARS-coronavirus-2 spike protein. 제1항 내지 제6항 중 어느 한 항의 결합 분자에 추가적으로 하나 이상의 태그가 결합된 이뮤노컨쥬게이트.The immunoconjugate to which one or more tags are additionally bound to the binding molecule of any one of claims 1 to 6. 제1항 내지 제6항 중 어느 한 항의 결합 분자를 암호화하는 핵산 분자.A nucleic acid molecule encoding the binding molecule of any one of claims 1-6. 제26항의 핵산 분자가 삽입된 발현 벡터.An expression vector into which the nucleic acid molecule of claim 26 is inserted. 제27항의 발현 벡터로 형질전환된 세포주.A cell line transformed with the expression vector of claim 27 . 제28항에 있어서,
상기 세포주는 CHO 세포, F2N 세포, COS 세포, BHK 세포, 바우스(Bowes) 흑색종 세포, HeLa 세포, 911 세포, HT1080 세포, A549 세포, HEK 293 세포 및 HEK293T 세포로 이루어진 군으로부터 선택된 어느 하나임을 특징으로 하는 세포주.29. The method of claim 28,
The cell line is characterized in that any one selected from the group consisting of CHO cells, F2N cells, COS cells, BHK cells, Bowes melanoma cells, HeLa cells, 911 cells, HT1080 cells, A549 cells, HEK 293 cells and HEK293T cells cell line with 제1항 내지 제6항 중 어느 한 항의 결합 분자를 포함하는 사스-코로나바이러스 감염증(COVID-19)의 진단, 예방 또는 치료용 조성물.Section 1 A composition for diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19), comprising the binding molecule of any one of claims 6 to 7. 제30항에 있어서,
하기 1) 내지 76)으로 이루어진 군으로부터 선택되는 어느 하나 이상의 변이 바이러스를 중화하기 위한 것인, 사스-코로나바이러스 감염증(COVID-19)의 진단, 예방 또는 치료용 조성물:
1) 사스-코로나바이러스-2의 스파이크 단백질의 69번 및 70번 아미노산 위치 중 하나 이상이 결실된 변이 바이러스;
2) 사스-코로나바이러스-2의 스파이크 단백질의 80번 아미노산 위치에서 D80A 변이가 생긴 변이 바이러스;
3) 사스-코로나바이러스-2의 스파이크 단백질의 222번 아미노산 위치에서 A222V 변이가 생긴 변이 바이러스;
4) 사스-코로나바이러스-2의 스파이크 단백질의 234번 아미노산 위치에서 N234Q 변이가 생긴 변이 바이러스;
5) 사스-코로나바이러스-2의 스파이크 단백질의 337번 아미노산 위치에서 P337S 변이가 생긴 변이 바이러스;
6) 사스-코로나바이러스-2의 스파이크 단백질의 338번 아미노산 위치에서 F338L 변이가 생긴 변이 바이러스;
7) 사스-코로나바이러스-2의 스파이크 단백질의 348번 아미노산 위치에서 A348S 변이가 생긴 변이 바이러스;
8) 사스-코로나바이러스-2의 스파이크 단백질의 367번 아미노산 위치에서 V367F 변이가 생긴 변이 바이러스;
9) 사스-코로나바이러스-2의 스파이크 단백질의 370번 아미노산 위치에서 N370S 변이가 생긴 변이 바이러스;
10) 사스-코로나바이러스-2의 스파이크 단백질의 372번 아미노산 위치에서 A372S 변이, A372T 변이 또는 A372V 변이가 생긴 변이 바이러스;
11) 사스-코로나바이러스-2의 스파이크 단백질의 341번 아미노산 위치에서 V341I 변이가 생긴 변이 바이러스;
12) 사스-코로나바이러스-2의 스파이크 단백질의 342번 아미노산 위치에서 F342L 변이가 생긴 변이 바이러스;
13) 사스-코로나바이러스-2의 스파이크 단백질의 344번 아미노산 위치에서 A344S 변이가 생긴 변이 바이러스;
14) 사스-코로나바이러스-2의 스파이크 단백질의 352번 아미노산 위치에서 A352S 변이가 생긴 변이 바이러스;
15) 사스-코로나바이러스-2의 스파이크 단백질의 354번 아미노산 위치에서 N354D 변이가 생긴 변이 바이러스;
16) 사스-코로나바이러스-2의 스파이크 단백질의 359번 아미노산 위치에서 S359N 변이가 생긴 변이 바이러스;
17) 사스-코로나바이러스-2의 스파이크 단백질의 377번 아미노산 위치에서 F377L 변이가 생긴 변이 바이러스;
18) 사스-코로나바이러스-2의 스파이크 단백질의 378번 아미노산 위치에서 K378R 변이 또는 K378N 변이가 생긴 변이 바이러스;
19) 사스-코로나바이러스-2의 스파이크 단백질의 384번 아미노산 위치에서 P384L 변이가 생긴 변이 바이러스;
20) 사스-코로나바이러스-2의 스파이크 단백질의 385번 아미노산 위치에서 T385A 변이가 생긴 변이 바이러스;
21) 사스-코로나바이러스-2의 스파이크 단백질의 393번 아미노산 위치에서 T393P 변이가 생긴 변이 바이러스;
22) 사스-코로나바이러스-2의 스파이크 단백질의 395번 아미노산 위치에서 V395I 변이가 생긴 변이 바이러스;
23) 사스-코로나바이러스-2의 스파이크 단백질의 405번 아미노산 위치에서 D405V 변이가 생긴 변이 바이러스;
24) 사스-코로나바이러스-2의 스파이크 단백질의 406번 아미노산 위치에서 E406Q 변이 또는 E406W 변이가 생긴 변이 바이러스;
25) 사스-코로나바이러스-2의 스파이크 단백질의 408번 아미노산 위치에서 R408I 변이가 생긴 변이 바이러스;
26) 사스-코로나바이러스-2의 스파이크 단백질의 409번 아미노산 위치에서 Q409E 변이가 생긴 변이 바이러스;
27) 사스-코로나바이러스-2의 스파이크 단백질의 414번 아미노산 위치에서 Q414A 변이, Q414E 변이 또는 Q414R 변이가 생긴 변이 바이러스;
28) 사스-코로나바이러스-2의 스파이크 단백질의 417번 아미노산 위치에서 K417N 변이, K417T 변이 또는 K417E 변이가 생긴 변이 바이러스;
29) 사스-코로나바이러스-2의 스파이크 단백질의 420번 아미노산 위치에서 D420N 변이가 생긴 변이 바이러스;
30) 사스-코로나바이러스-2의 스파이크 단백질의 435번 아미노산 위치에서 A435S 변이가 생긴 변이 바이러스;
31) 사스-코로나바이러스-2의 스파이크 단백질의 436번 아미노산 위치에서 W436R 변이가 생긴 변이 바이러스;
32) 사스-코로나바이러스-2의 스파이크 단백질의 439번 아미노산 위치에서 N439K 변이가 생긴 변이 바이러스;
33) 사스-코로나바이러스-2의 스파이크 단백질의 440번 아미노산 위치에서 N440K 변이 또는 N440D 변이가 생긴 변이 바이러스;
34) 사스-코로나바이러스-2의 스파이크 단백질의 444번 아미노산 위치에서 K444Q 변이 또는 K444R 변이가 생긴 변이 바이러스;
35) 사스-코로나바이러스-2의 스파이크 단백질의 445번 아미노산 위치에서 V445A 변이 또는 V445F 변이가 생긴 변이 바이러스;
36) 사스-코로나바이러스-2의 스파이크 단백질의 446번 아미노산 위치에서 G446V 변이 또는 G446S 변이가 생긴 변이 바이러스;
37) 사스-코로나바이러스-2의 스파이크 단백질의 449번 아미노산 위치에서 Y449N 변이가 생긴 변이 바이러스;
38) 사스-코로나바이러스-2의 스파이크 단백질의 452번 아미노산 위치에서 L452R 변이가 생긴 변이 바이러스;
39) 사스-코로나바이러스-2의 스파이크 단백질의 453번 아미노산 위치에서 Y453F 변이가 생긴 변이 바이러스;
40) 사스-코로나바이러스-2의 스파이크 단백질의 455번 아미노산 위치에서 L455F 변이가 생긴 변이 바이러스;
41) 사스-코로나바이러스-2의 스파이크 단백질의 456번 아미노산 위치에서 F456L 변이 또는 F456E 변이가 생긴 변이 바이러스;
42) 사스-코로나바이러스-2의 스파이크 단백질의 458번 아미노산 위치에서 K458R 변이 또는 K458Q 변이가 생긴 변이 바이러스;
43) 사스-코로나바이러스-2의 스파이크 단백질의 460번 아미노산 위치에서 N460T 변이가 생긴 변이 바이러스;
44) 사스-코로나바이러스-2의 스파이크 단백질의 471번 아미노산 위치에서 E471Q 변이가 생긴 변이 바이러스;
45) 사스-코로나바이러스-2의 스파이크 단백질의 472번 아미노산 위치에서 I472V 변이가 생긴 변이 바이러스;
46) 사스-코로나바이러스-2의 스파이크 단백질의 473번 아미노산 위치에서 Y473F 변이가 생긴 변이 바이러스;
47) 사스-코로나바이러스-2의 스파이크 단백질의 475번 아미노산 위치에서 A475V 변이가 생긴 변이 바이러스;
48) 사스-코로나바이러스-2의 스파이크 단백질의 476번 아미노산 위치에서 G476S 변이가 생긴 변이 바이러스;
49) 사스-코로나바이러스-2의 스파이크 단백질의 477번 아미노산 위치에서 S477N 변이, S477R 변이, S477I 변이 또는 S477R 변이가 생긴 변이 바이러스;
50) 사스-코로나바이러스-2의 스파이크 단백질의 478번 아미노산 위치에서 T478K 변이 또는 T478I 변이가 생긴 변이 바이러스;
51) 사스-코로나바이러스-2의 스파이크 단백질의 479번 아미노산 위치에서 P479S 변이가 생긴 변이 바이러스;
52) 사스-코로나바이러스-2의 스파이크 단백질의 481번 아미노산 위치에서 N481D 변이가 생긴 변이 바이러스;
53) 사스-코로나바이러스-2의 스파이크 단백질의 482번 아미노산 위치에서 G482S 변이가 생긴 변이 바이러스;
54) 사스-코로나바이러스-2의 스파이크 단백질의 483번 아미노산 위치에서 V483A 변이 또는 V483I 변이가 생긴 변이 바이러스;
55) 사스-코로나바이러스-2의 스파이크 단백질의 484번 아미노산 위치에서 E484K 변이, E484G 변이 또는 E484Q 변이가 생긴 변이 바이러스;
56) 사스-코로나바이러스-2의 스파이크 단백질의 485번 아미노산 위치에서 G485S변이가 생긴 변이 바이러스;
57) 사스-코로나바이러스-2의 스파이크 단백질의 486번 아미노산 위치에서 F486S 변이, F486L 변이, F486V 변이 또는 F486I 변이가 생긴 변이 바이러스;
58) 사스-코로나바이러스-2의 스파이크 단백질의 489번 아미노산 위치에서 Y489H 변이가 생긴 변이 바이러스;
59) 사스-코로나바이러스-2의 스파이크 단백질의 490번 아미노산 위치에서 F490S 변이가 생긴 변이 바이러스;
60) 사스-코로나바이러스-2의 스파이크 단백질의 493번 아미노산 위치에서 Q493K 변이, Q493R 변이, Q493M 변이, Q493Y 변이 또는 Q493A 변이가 생긴 변이 바이러스;
61) 사스-코로나바이러스-2의 스파이크 단백질의 494번 아미노산 위치에서 S494Q 변이, S494L 변이 또는 S494P 변이가 생긴 변이 바이러스;
62) 사스-코로나바이러스-2의 스파이크 단백질의 498번 아미노산 위치에서 Q498H 변이가 생긴 변이 바이러스;
63) 사스-코로나바이러스-2의 스파이크 단백질의 499번 아미노산 위치에서 P499R 변이가 생긴 변이 바이러스;
64) 사스-코로나바이러스-2의 스파이크 단백질의 501번 아미노산 위치에서 N501Y 변이, N501T 변이 또는 N501F 변이가 생긴 변이 바이러스;
65) 사스-코로나바이러스-2의 스파이크 단백질의 503번 아미노산 위치에서 V503F 변이가 생긴 변이 바이러스;
66) 사스-코로나바이러스-2의 스파이크 단백질의 505번 아미노산 위치에서 Y505C 변이가 생긴 변이 바이러스;
67) 사스-코로나바이러스-2의 스파이크 단백질의 508번 아미노산 위치에서 Y508H 변이가 생긴 변이 바이러스;
68) 사스-코로나바이러스-2의 스파이크 단백질의 520번 아미노산 위치에서 A520S 변이 또는 A520V 변이가 생긴 변이 바이러스;
69) 사스-코로나바이러스-2의 스파이크 단백질의 521번 아미노산 위치에서 P521R 변이 또는 P521S 변이가 생긴 변이 바이러스;
70) 사스-코로나바이러스-2의 스파이크 단백질의 522번 아미노산 위치에서 A522S 변이 또는 A522V 변이가 생긴 변이 바이러스;
71) 사스-코로나바이러스-2의 스파이크 단백질의 614번 아미노산 위치에서 D614G 변이가 생긴 변이 바이러스;
72) 사스-코로나바이러스-2의 스파이크 단백질의 677번 아미노산 위치에서 Q677H 변이가 생긴 변이 바이러스;
73) 사스-코로나바이러스-2의 스파이크 단백질의 681번 아미노산 위치에서 P681H 변이 또는 P681R 변이가 생긴 변이 바이러스;
74) 사스-코로나바이러스-2의 스파이크 단백질의 685번 아미노산 위치에서 R685H 변이가 생긴 변이 바이러스;
75) 사스-코로나바이러스-2의 스파이크 단백질의 701번 아미노산 위치에서 A701V 변이가 생긴 변이 바이러스;
및
76) 사스-코로나바이러스-2의 스파이크 단백질의 1176번 아미노산 위치에서 V1176F 변이가 생긴 변이 바이러스.31. The method of claim 30,
To neutralize any one or more mutated viruses selected from the group consisting of the following 1) to 76), a composition for diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19):
1) a mutant virus in which at least one of amino acid positions 69 and 70 of the spike protein of SARS-coronavirus-2 is deleted;
2) SARS-Coronavirus-2 mutant virus with D80A mutation at amino acid position 80 of the spike protein;
3) a mutant virus with A222V mutation at amino acid position 222 of the spike protein of SARS-coronavirus-2;
4) a mutant virus with N234Q mutation at amino acid position 234 of the SARS-coronavirus-2 spike protein;
5) SARS-Coronavirus-2 mutant virus with P337S mutation at amino acid position 337 of the spike protein;
6) a mutant virus with F338L mutation at amino acid position 338 of the SARS-coronavirus-2 spike protein;
7) a mutant virus with A348S mutation at amino acid position 348 of the SARS-coronavirus-2 spike protein;
8) SARS-Coronavirus-2 mutant virus with V367F mutation at amino acid position 367 of the spike protein;
9) SARS-Coronavirus-2 mutant virus with N370S mutation at amino acid position 370 of the spike protein;
10) a mutant virus having A372S mutation, A372T mutation or A372V mutation at amino acid position 372 of the SARS-coronavirus-2 spike protein;
11) a mutant virus with V341I mutation at amino acid position 341 of the SARS-coronavirus-2 spike protein;
12) a mutant virus in which F342L mutation occurred at amino acid position 342 of the SARS-coronavirus-2 spike protein;
13) SARS-Coronavirus-2 mutant virus with A344S mutation at amino acid position 344 of the spike protein;
14) a mutant virus having an A352S mutation at amino acid position 352 of the SARS-coronavirus-2 spike protein;
15) a mutant virus with N354D mutation at amino acid position 354 of the SARS-coronavirus-2 spike protein;
16) a mutant virus with S359N mutation at amino acid position 359 of the SARS-coronavirus-2 spike protein;
17) a mutant virus with F377L mutation at amino acid position 377 of the SARS-coronavirus-2 spike protein;
18) SARS-coronavirus-2 mutant virus in which K378R mutation or K378N mutation occurs at amino acid position 378 of the spike protein;
19) SARS-Coronavirus-2 mutant virus with P384L mutation at amino acid position 384 of the spike protein;
20) a mutant virus with T385A mutation at amino acid position 385 of the SARS-coronavirus-2 spike protein;
21) a mutant virus having T393P mutation at amino acid position 393 of the SARS-coronavirus-2 spike protein;
22) a mutant virus with V395I mutation at amino acid position 395 of the SARS-coronavirus-2 spike protein;
23) a mutant virus in which D405V mutation occurred at amino acid position 405 of the SARS-coronavirus-2 spike protein;
24) a mutant virus having E406Q mutation or E406W mutation at amino acid position 406 of the SARS-coronavirus-2 spike protein;
25) SARS-coronavirus-2 mutant virus with R408I mutation at amino acid position 408 of the spike protein;
26) a mutant virus having Q409E mutation at amino acid position 409 of the SARS-coronavirus-2 spike protein;
27) a mutant virus having Q414A mutation, Q414E mutation, or Q414R mutation at amino acid position 414 of the SARS-coronavirus-2 spike protein;
28) a mutant virus in which K417N mutation, K417T mutation or K417E mutation occurs at amino acid position 417 of the SARS-coronavirus-2 spike protein;
29) SARS-Coronavirus-2 mutant virus with D420N mutation at amino acid position 420 of the spike protein;
30) SARS-Coronavirus-2 mutant virus with A435S mutation at amino acid position 435 of the spike protein;
31) SARS-coronavirus-2 mutant virus in which W436R mutation occurred at amino acid position 436 of the spike protein;
32) a mutant virus with N439K mutation at amino acid position 439 of the SARS-coronavirus-2 spike protein;
33) SARS-coronavirus-2 mutant virus in which N440K mutation or N440D mutation occurs at amino acid position 440 of the spike protein;
34) a mutant virus in which K444Q mutation or K444R mutation occurs at amino acid position 444 of the SARS-coronavirus-2 spike protein;
35) SARS-coronavirus-2 mutant virus in which V445A mutation or V445F mutation occurs at amino acid position 445 of the spike protein;
36) SARS-Coronavirus-2, a mutant virus having G446V mutation or G446S mutation at amino acid position 446 of the spike protein;
37) a mutant virus with Y449N mutation at amino acid position 449 of the SARS-coronavirus-2 spike protein;
38) SARS-Coronavirus-2 mutant virus with L452R mutation at amino acid position 452 of the spike protein;
39) a mutant virus in which Y453F mutation occurs at amino acid position 453 of the SARS-coronavirus-2 spike protein;
40) SARS-Coronavirus-2 mutant virus with L455F mutation at amino acid position 455 of the spike protein;
41) a mutant virus having F456L mutation or F456E mutation at amino acid position 456 of the SARS-coronavirus-2 spike protein;
42) a mutant virus having K458R mutation or K458Q mutation at amino acid position 458 of the SARS-coronavirus-2 spike protein;
43) SARS-Coronavirus-2 mutant virus with N460T mutation at amino acid position 460 of the spike protein;
44) SARS-coronavirus-2 mutant virus with E471Q mutation at amino acid position 471 of the spike protein;
45) SARS-coronavirus-2 mutant virus with I472V mutation at amino acid position 472 of the spike protein;
46) a mutant virus in which a Y473F mutation occurred at amino acid position 473 of the SARS-coronavirus-2 spike protein;
47) a mutant virus having A475V mutation at amino acid position 475 of the SARS-coronavirus-2 spike protein;
48) a mutant virus in which a G476S mutation occurred at amino acid position 476 of the SARS-coronavirus-2 spike protein;
49) S477N mutation, S477R mutation, S477I mutation or S477R mutation at amino acid position 477 of the spike protein of SARS-coronavirus-2;
50) SARS-Coronavirus-2 mutant virus in which T478K mutation or T478I mutation occurs at amino acid position 478 of the spike protein;
51) SARS-coronavirus-2 mutant virus with P479S mutation at amino acid position 479 of the spike protein;
52) SARS-Coronavirus-2 mutant virus with N481D mutation at amino acid position 481 of the spike protein;
53) SARS-Coronavirus-2 mutant virus in which G482S mutation occurred at amino acid position 482 of the spike protein;
54) a mutant virus having V483A mutation or V483I mutation at amino acid position 483 of the SARS-coronavirus-2 spike protein;
55) a mutant virus having E484K mutation, E484G mutation or E484Q mutation at amino acid position 484 of the SARS-coronavirus-2 spike protein;
56) SARS-Coronavirus-2 mutant virus with G485S mutation at amino acid position 485 of the spike protein;
57) a mutant virus having F486S mutation, F486L mutation, F486V mutation or F486I mutation at amino acid position 486 of the SARS-coronavirus-2 spike protein;
58) SARS-coronavirus-2 mutant virus in which Y489H mutation occurred at amino acid position 489 of the spike protein;
59) SARS-coronavirus-2 mutant virus with F490S mutation at amino acid position 490 of the spike protein;
60) a mutant virus having Q493K mutation, Q493R mutation, Q493M mutation, Q493Y mutation or Q493A mutation at amino acid position 493 of the SARS-coronavirus-2 spike protein;
61) SARS-Coronavirus-2 mutant virus having S494Q mutation, S494L mutation or S494P mutation at amino acid position 494 of the spike protein;
62) a mutant virus in which a Q498H mutation occurred at amino acid position 498 of the SARS-coronavirus-2 spike protein;
63) SARS-coronavirus-2 mutant virus with P499R mutation at amino acid position 499 of the spike protein;
64) a mutant virus having N501Y mutation, N501T mutation or N501F mutation at amino acid position 501 of the SARS-coronavirus-2 spike protein;
65) a mutant virus in which V503F mutation occurred at amino acid position 503 of the SARS-coronavirus-2 spike protein;
66) a mutant virus with Y505C mutation at amino acid position 505 of the SARS-coronavirus-2 spike protein;
67) a mutant virus with Y508H mutation at amino acid position 508 of the SARS-coronavirus-2 spike protein;
68) SARS-Coronavirus-2 mutant virus with A520S mutation or A520V mutation at amino acid position 520 of the spike protein;
69) SARS-Coronavirus-2, a mutant virus having P521R mutation or P521S mutation at amino acid position 521 of the spike protein;
70) a mutant virus having A522S mutation or A522V mutation at amino acid position 522 of the SARS-coronavirus-2 spike protein;
71) SARS-Coronavirus-2 mutant virus with D614G mutation at amino acid position 614 of the spike protein;
72) a mutant virus with Q677H mutation at amino acid position 677 of the SARS-coronavirus-2 spike protein;
73) a mutant virus having P681H mutation or P681R mutation at amino acid position 681 of the SARS-coronavirus-2 spike protein;
74) a mutant virus with R685H mutation at amino acid position 685 of the SARS-coronavirus-2 spike protein;
75) a mutant virus having A701V mutation at amino acid position 701 of the SARS-coronavirus-2 spike protein;
and
76) A mutant virus with V1176F mutation at amino acid position 1176 of the SARS-coronavirus-2 spike protein. 제31항에 있어서, 상기 조성물은 멸균 주사용액, 동결건조(lyophilized) 제형, 사전 충전식 주사(pre-filled syringe) 용액제, 경구형 제형, 외용제 또는 좌제임을 특징으로 하는 조성물.32. The composition of claim 31, wherein the composition is a sterile injection solution, a lyophilized formulation, a pre-filled syringe solution, an oral formulation, an external formulation, or a suppository. 제1항 내지 제6항 중 어느 한 항의 결합 분자를 포함하는 사스-코로나바이러스 감염증(COVID-19) 진단, 예방 또는 치료용 키트.Section 1 A kit for diagnosis, prevention or treatment of SARS-coronavirus infection (COVID-19) comprising the binding molecule of any one of claims 6 to 7. 사스-코로나바이러스 감염증(COVID-19)으로 인하여 발생하는 질환을 가진 대상에 제31항 내지 제32항 중 어느 한 항의 조성물을 치료학적으로 유효한 양으로 투여하는 단계를 포함하는, 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료 방법.SARS-coronavirus infection (COVID-19) comprising administering the composition of any one of claims 31 to 32 in a therapeutically effective amount to a subject having a disease caused by SARS-coronavirus infection Diagnosis, prevention or treatment of diseases caused by 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질(Spike protein, S protein)의 RBD(Receptor Binding Domain) 내 에피토프와의 결합 여부를 확인하여, 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료용 결합 분자를 선별하는 방법으로서,
상기 결합 분자의 에피토프는
사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 417, 449, 453, 455, 456, 484, 486, 489, 490, 493, 496 및 505로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 잔기(residue)를 포함하고,
상기 에피토프 및 결합 분자가 결합을 보이는 경우 상기 결합 분자를 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료용 후보 물질로 판단하는 것을 특징으로 하는, 방법.Diseases caused by SARS-coronavirus infection by checking whether or not the spike protein (S protein) of SARS-CoV-2 binds to an epitope in RBD (Receptor Binding Domain) As a method of screening a binding molecule for diagnosis, prevention or treatment of
The epitope of the binding molecule is
comprising at least one amino acid residue selected from the group consisting of amino acid positions 417, 449, 453, 455, 456, 484, 486, 489, 490, 493, 496 and 505 of the SARS-coronavirus-2 spike protein do,
When the epitope and the binding molecule show binding, the binding molecule is judged as a candidate material for diagnosis, prevention or treatment of a disease caused by SARS-coronavirus infection, the method. 제35항에 있어서,
상기 결합 분자의 에피토프는
사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치
403, 450, 452, 483, 485, 492, 494 및 495로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 잔기를 추가로 포함함을 특징으로 하는, 방법.36. The method of claim 35,
The epitope of the binding molecule is
Amino acid positions of the SARS-coronavirus-2 spike protein
403, 450, 452, 483, 485, 492, 494 and 495, the method further comprising one or more amino acid residues selected from the group consisting of. 사스-코로나바이러스-2(SARS-CoV-2)의 스파이크 단백질(Spike protein, S protein)의 RBD(Receptor Binding Domain) 내 에피토프와의 결합 여부를 확인하여, 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료용 결합 분자를 생산하는 방법으로서,
상기 결합 분자의 에피토프는
사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 417, 449, 453, 455, 456, 484, 486, 489, 490, 493, 496 및 505로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 잔기(residue)를 포함하고,
상기 에피토프 및 결합 분자가 결합을 보이는 경우 상기 결합 분자를 사스-코로나바이러스 감염증으로 인하여 발생하는 질환의 진단, 예방 또는 치료용 후보 물질로 판단하는 것을 특징으로 하는, 방법.Diseases caused by SARS-coronavirus infection by checking whether or not the spike protein (S protein) of SARS-CoV-2 binds to an epitope in RBD (Receptor Binding Domain) A method of producing a binding molecule for diagnosis, prevention or treatment of
The epitope of the binding molecule is
comprising at least one amino acid residue selected from the group consisting of amino acid positions 417, 449, 453, 455, 456, 484, 486, 489, 490, 493, 496 and 505 of the SARS-coronavirus-2 spike protein do,
When the epitope and the binding molecule show binding, the binding molecule is judged as a candidate material for diagnosis, prevention or treatment of a disease caused by SARS-coronavirus infection, the method. 제37항에 있어서,
상기 결합 분자의 에피토프는
사스-코로나바이러스-2의 스파이크 단백질의 아미노산 위치 403, 450, 452, 483, 485, 492, 494 및 495로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 잔기를 추가로 포함함을 특징으로 하는, 방법.38. The method of claim 37,
The epitope of the binding molecule is
The method of claim 1, further comprising one or more amino acid residues selected from the group consisting of amino acid positions 403, 450, 452, 483, 485, 492, 494 and 495 of the spike protein of SARS-coronavirus-2.
KR1020210096237A 2020-07-23 2021-07-22 SARS-CoV-2 NEUTRALIZING BINDING MOLECULE BINDING TO EPITOPES OF SARS-CoV-2 SPIKE PROTEIN KR20220012826A (en)

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