KR20210158168A - Invasive glucose meter using nir spectroscopy and method of measuring glucose meter using the same - Google Patents

Abstract

The present invention relates to an invasive glucose meter using near-infrared rays and a glucose measurement method using the same, and is to provide a glucose meter that does not require blood collection by using a near-infrared light source and visible light. To this end, the invasive glucose meter includes: a light emitting unit which generates at least one light source in a near-infrared and visible light section; a light receiving unit which measures a second amount of light transmitted/scattered from the light source when the light source transmits/scatters the light in a human body; a control unit which controls operations of the light emitting unit and the light receiving unit; a signal processing unit which extracts valid data from the second amount of light and calculates a glucose level by applying a glucose model to the effective data; and a model generating unit which generates the glucose model.

Description

Non-blood blood glucose meter using near-infrared rays and blood glucose measurement method using the same

The present invention relates to a non-blood blood glucose meter using near-infrared rays and a blood glucose measurement method using the same, and more particularly, to a blood glucose meter using near-infrared rays without collecting blood in measuring blood glucose.

In a modern society, the number of diabetic patients is rapidly increasing due to the problem of eating habits. Diabetes mellitus is a type of metabolic disease in which insulin secretion is insufficient or normal function is not achieved, and refers to a disease characterized by high blood glucose concentration. Diabetes is divided into type 1 diabetes in which insulin is not produced at all and type 2 diabetes in which insulin is relatively insufficient. Since type 1 diabetes needs to periodically measure blood sugar using a blood glucose meter and supply insulin several times a day for blood sugar control, many efforts have been made to enable it to be used in daily life and to enable long-term blood sugar control.

However, in the blood sampling process for measuring the diabetic index, many patients are at risk of infection, and there is a problem in that they feel pain due to the use of the blood collection device and feel fear of blood collection.

An object of the present invention is to solve the above problems, and an object of the present invention is to provide a blood glucose meter that does not require blood sampling using a near-infrared light source and visible light.

Another object of the present invention is to generate a blood glucose model based on a plurality of blood glucose measurement data in order to measure blood glucose using a light source.

In order to achieve this object, the non-blood blood glucose meter of the present invention using near infrared rays of the present invention includes a light emitting unit that generates at least one light source in the near infrared and visible ray sections, and when the light source transmits/scatters the body, the light source transmits / A light receiving unit for measuring the second light amount of scattered light, a control unit for controlling the operations of the light emitting unit and the light receiving unit, a signal processing unit for extracting effective data from the second light amount, and applying a blood glucose model to the effective data to calculate the blood glucose level, and the and a model generator for generating a blood glucose model.

In addition, the present invention provides a method for measuring blood sugar using a blood glucose meter without blood sampling, in step a of measuring a first light amount by shielding a light receiving unit, and irradiating at least one light source in the near infrared and visible light range to the user's body. step b, measuring the second light amount of each transmitted/scattered light when the light source transmits/scatters the body, extracting effective data from the second light amount, and applying a blood glucose model to the effective data and a step d of calculating the blood glucose level and a step e of storing the blood glucose level and the user's unique identification number in a database, and transmitting the blood glucose level to a user terminal.

According to the present invention as described above, it is possible to provide a blood glucose meter that does not require blood collection using a near-infrared light source and visible light. This makes it easier for diabetic patients to measure blood sugar by reducing the pain and risk of infection during the blood sampling process.

1 is a perspective view showing the configuration of a blood glucose meter using a light source according to an embodiment of the present invention;
2 is a flowchart for explaining a method of measuring blood glucose using a non-blood glucose meter according to an embodiment of the present invention;
3 is a diagram illustrating a pulse waveform of a light source irradiated from a non-blood blood glucose meter according to an embodiment of the present invention.

The above-described objects, features and advantages will be described below in detail with reference to the accompanying drawings, and accordingly, those of ordinary skill in the art to which the present invention pertains will be able to easily implement the technical idea of the present invention. In describing the present invention, if it is determined that a detailed description of a known technology related to the present invention may unnecessarily obscure the gist of the present invention, the detailed description will be omitted.

In the drawings, the same reference numerals are used to indicate the same or similar elements, and all combinations described in the specification and claims may be combined in any manner. And unless otherwise provided, it is to be understood that references to the singular may include one or more, and references to the singular may also include plural expressions.

The terminology used herein is for the purpose of describing specific exemplary embodiments only and is not intended to be limiting. As used herein, singular expressions may also be intended to include plural meanings unless the sentence clearly indicates otherwise. The term “and/or,” “and/or” includes any and all combinations of the items listed therewith. The terms "comprises", "comprising", "comprising", "comprising", "having", "having", etc. have an implicit meaning, so that these terms refer to their described features, integers, It specifies steps, operations, elements, and/or components and does not exclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. The steps, processes, and acts of the methods described herein should not be construed as necessarily performing their performance in such a specific order as discussed or exemplified, unless specifically determined to be an order of performance thereof. . It should also be understood that additional or alternative steps may be used.

In addition, each of the components may be implemented as a hardware processor, the above components may be integrated into one hardware processor, or the above components may be combined with each other and implemented as a plurality of hardware processors.

Hereinafter, preferred embodiments according to the present invention will be described in detail with reference to the accompanying drawings.

1 is a perspective view showing the structure of a blood glucose meter according to an embodiment of the present invention. Referring to FIG. 1 , a non-blood blood glucose meter is mounted on a person's abdomen to measure blood sugar, and more specifically, a light emitting unit 100 , a light receiving unit 200 , a control unit 300 , a signal processing unit 400 , It may include a model generating unit 500 , a storage unit 600 , a display unit 700 , and a communication unit 800 .

The light emitting unit 100 may irradiate a light source to a person's abdomen. The light emitting unit 100 may include a first light emitting device generating a light source having a wavelength of a visible ray region, and a second light emitting device and a third light emitting device generating a light source having a different wavelength of the near infrared region. Blood sugar can be measured more accurately by selecting a light source having a wavelength having low absorption for fat and water as a light source irradiated from the first to third light emitting devices. For example, in the case of a light source irradiated from the first light emitting device, a wavelength of a red light source near 600 nm is selected, and in the case of a light source irradiated from the second and third light emitting devices, a near-infrared wavelength (NIR, Near InfraRed) may be selected.

When the light source irradiated by the light emitting unit 100 transmits/scatters the abdomen, the light receiving unit 200 may receive transmitted/scattered light of the light source transmitted/scattered through the abdomen. The light receiving unit 200 may receive light transmitted/scattered through a person's abdomen, and may include an optical sensor capable of measuring the amount of light of the light source irradiated by the first to third light emitting devices.

The control unit 300 controls the operation of the light emitting unit 100 and the light receiving unit 200 to measure the amount of light. The controller 300 may control the light emitting unit 100 by converting digital data into an analog output.

First, the control unit 300 light-shields the light-receiving unit 200 and stops the operations of the first to third light-emitting devices of the light-emitting unit 100, and then determines the amount of light when the light-receiving unit 200 is light-shielded, that is, the amount of dark light. can be measured The control unit 300 will use a mechanical method commonly used in light-shielding the light receiving unit 200 .

When the first light amount is calculated, the controller 300 may sequentially operate the first to third light emitting devices of the light emitting unit 100 to measure the second light amount. The control unit 300 separately operates each of the three light emitting devices in order to utilize the effect of movement of blood glucose molecules due to light heating. The control unit 300 may apply a low pass filter (LPF) in operating the light emitting unit 100 . In this case, the control unit 300 may operate the light emitting unit 100 in two modes according to the pulse period of the light source irradiated from the light emitting unit 100 .

1) Long term - LPF

The controller 300 may sequentially operate the first to third light emitting devices by using 1.5 times the average number of pulses of the user as the pulse period of the first to third light emitting devices. Since the amount of transmitted/scattered light fluctuates according to a change in blood flow when blood glucose is measured, in order to prevent this, the present invention can set the pulse period longer than the user's average pulse rate to make the amount of transmitted/scattered light constant. Accordingly, in the present invention, the light source can be irradiated with 1.5 times the average pulse rate of the user as the pulse period.

In the case of a long term-LPF, the pulse waveforms of the light sources irradiated from the first to third light emitting devices are as shown in FIG. 3A . 3A, the control unit 300 operates the first light emitting device to irradiate the light source with a pulse period of 1.5 times the average pulse rate of the user, and then the second light emitting device causes the first The light emitting element may be operated to irradiate the light source with the same pulse period, and then the third light emitting element may also be operated to irradiate the light source with the same pulse period.

2) Short term-LPF

The controller 300 may sequentially operate the first to third light emitting devices by using 10 msec as the pulse period of the first to third light emitting devices. In order to minimize the user's movement while measuring the amount of transmitted/scattered light, the pulse period may be 10 msec. This is to prevent a change in the amount of transmitted/scattered light according to a user's movement when the pulse period of the light source is long.

In the case of short term-LPF, the pulse waveforms of the light sources irradiated from the first to third light emitting devices are as shown in FIG. 3(b). 3B, the control unit 300 operates the first light emitting device to irradiate the light source with a pulse period of 10 msec, and then the second light emitting device irradiates the light source with a pulse period of 10 msec. operation, and then the third light emitting device may also be operated to irradiate the light source with a pulse period of 10 msec.

The signal processing unit 400 may convert the first and second light amounts measured by the light receiving unit 200 into digital data, and calculate a blood glucose level based on the converted data. Specifically, the signal processing unit 400 may include a converting unit 410 for converting the amount of light into digital data and a calculating unit 430 for calculating the blood glucose level.

The conversion unit 410 may convert the first and second light amounts measured by the light receiving unit 200 into digital data. The converter 410 will use a commonly used ADC.

The operation unit 430 may measure the user's blood glucose level by using the light quantity and the blood glucose model converted by the converting unit 410 . At this time, the operation unit 430 will use a 10-dimensional vector because 10 pieces of valid data can be used in measuring the blood glucose level.

The blood glucose model is generated by the model generating unit 500, and the model generating unit 500 calculates the blood glucose level that changes according to the second light quantity for a plurality of transmitted/scattered light in order to calculate the user's blood glucose level. can create

In generating the blood glucose model, the model generator 500 includes 10 parameters related to the second light quantity measured in the long term-LPF mode and the short term-LPF mode for a preset period T1 for collection of experimental data; In addition, the blood glucose level measured through blood sampling at the same time may be used.

Specifically, the model generating unit 500 sets the average value of the second light quantity for the light source irradiated from the first light emitting device obtained in the long term-LPF mode during T1 to the first parameter, the light source irradiated from the second light emitting device. An average value of the second light amount for the light source may be set as the second parameter, and an average value of the second light amount with respect to the light source irradiated from the third light emitting device may be set as the third parameter.

Furthermore, the model generator 500 may set the first light amount calculated by the controller 300 as a fourth parameter.

In addition, the model generator 500 calculates the average value of the second light quantity with respect to the light source irradiated from the first light emitting device obtained in the short term-LPF mode during T1 as a fifth parameter, and the second light source for the light source irradiated from the second light emitting device. The average value of the second light quantity is the sixth parameter, the average value of the second light quantity with respect to the light source irradiated from the third light emitting device is the 7th parameter, and the peak value of the second light quantity with respect to the light source irradiated from the first light emitting device is the 8th parameter The parameter, a peak value of the second amount of light with respect to the light source irradiated from the second light emitting device may be set as the ninth parameter, and the peak value of the second amount of light with respect to the light source irradiated from the third light emitting device may be set as the tenth parameter.

Since the blood glucose model is learned through a plurality of experiments, the model generator 500 uses the first to tenth parameters extracted during T1 through the non-blood blood glucose meter according to an embodiment of the present invention and the blood glucose level calculated therefrom. , and learning using blood glucose levels measured through blood sampling at the same time. Through this process, the accuracy of the blood glucose model was improved.

The calculator 430 may extract valid data applicable to the blood glucose model from the amount of light converted by the converter 410 . The calculating unit 430 calculates the average value of the second light quantity with respect to the light source irradiated from the first light emitting device obtained in the long term-LPF mode as first valid data, and the second light source for the light source irradiated from the second light emitting device is used as first valid data. The average value of the light amount may be calculated to be set as the second effective data, and the average value of the second light amount with respect to the light source irradiated from the third light emitting device may be calculated and set as the third effective data.

The calculator 430 may set the first light amount calculated by the controller 300 as the fourth valid data.

The calculating unit 430 calculates the average value of the second light quantity with respect to the light source irradiated from the first light emitting device obtained in the short term-LPF mode as fifth valid data and the average of the second light quantity with respect to the light source irradiated from the second light emitting device. The value may be set as the sixth effective data, and the average value of the second amount of light with respect to the light source irradiated from the third light emitting device may be set as the seventh valid data.

The calculating unit 430 calculates the peak value of the second light amount with respect to the light source irradiated from the first light emitting device obtained in the short term-LPF mode as eighth effective data, and the peak value of the second light amount with respect to the light source irradiated from the second light emitting device is obtained in the short term-LPF mode. The value may be set as the ninth valid data, and the peak value of the second amount of light with respect to the light source irradiated from the third light emitting device may be set as the tenth valid data.

The calculator 430 may calculate the blood sugar level by applying the set first to tenth valid data to the blood sugar model.

The storage unit 600 may store the first to tenth valid data used to calculate the blood glucose level and the blood glucose level calculated therefrom in the database.

The display unit 700 displays the calculated blood glucose level so that the user can check the blood glucose level, and the communication unit 800 can transmit the blood glucose level to the user's personal terminal using wireless communication. The communication unit 800 may use wireless communication such as ZigBee, Bluetooth, RF, Wi-Fi, IrDA, etc. for communication with the user terminal.

Hereinafter, a blood glucose measurement method using a non-blood blood glucose meter will be described with reference to FIG. 2 . In the description of the blood glucose measurement method, the detailed embodiment overlapping with the above-described non-blood blood glucose meter may be omitted.

FIG. 2 is a flowchart for explaining a method for measuring blood glucose using a non-blood glucose meter according to an embodiment of the present invention. Referring to FIG. 2 , the non-blood glucose meter includes a light-shielding unit and a first The amount of light can be measured (S100). Specifically, the non-blood blood glucose meter includes a first light emitting device generating a light source having a wavelength in the visible light region, and second and third light emitting devices generating light sources having different wavelengths in the near infrared region. may measure the amount of dark light after the light receiving unit is light-shielded and the operations of the first to third light emitting devices are stopped.

The non-blood blood glucose meter may irradiate a light source using the first to third light emitting devices on the user's body, particularly the abdomen, and measure the second amount of light transmitted/scattered to the user's body (S200) ). In this case, when irradiating the light source, the non-blood blood glucose meter may use at least one mode according to the pulse period of the light source irradiated from the first to third light emitting devices.

In the long term-LPF mode, the blood glucose meter can use 1.5 times the user's average pulse rate as the pulse period of the first to third light emitting devices, and in the short term-LPF mode, the first to third light emitting devices A pulse period of 10 msec can be used.

The non-blood blood glucose meter may extract effective data from the measured second light amount ( S300 ). Valid data are the average value of the second light quantity with respect to the light source of the first light emitting device measured in the long term-LPF mode, the average value of the second light quantity with respect to the light source irradiated from the second light emitting device, and the third light emitting device irradiated The average value of the second light quantity for the light source, the average value of the second light quantity for the light source irradiated from the first light emitting device obtained in the short term-LPF mode, the second light quantity for the light source irradiated from the second light emitting device The average value, the average value of the second light quantity for the light source irradiated from the third light emitting device, the peak value of the second light quantity for the light source irradiated from the first light emitting device obtained in the short term-LPF mode, and the second light emitting device It may include a peak value of the second amount of light with respect to the irradiated light source and the peak value of the second amount of light with respect to the light source irradiated from the third light emitting device.

The non-blood glucose meter may calculate the blood glucose level by applying the extracted valid data and the first light quantity calculated in step 100 to the blood glucose model ( S400 ). The non-blood glucose meter will use a 10-dimensional vector as 10 valid data are available to perform step 400 .

Thereafter, the non-blood glucose meter may store the blood glucose level and valid data in the database and transmit it to the user terminal (S500).

The embodiments of the present invention disclosed in the present specification and drawings are merely provided for specific examples to easily explain the technical content of the present invention and help the understanding of the present invention, and are not intended to limit the scope of the present invention. It will be apparent to those of ordinary skill in the art to which the present invention pertains that other modifications based on the technical spirit of the present invention can be implemented in addition to the embodiments disclosed herein.

Claims (10)

Non-blood blood glucose meter using near-infrared rays,
a light emitting unit generating a light source in at least one near-infrared light and a visible light section;
a light receiving unit configured to measure a second amount of light transmitted/scattered from the light source when the light source transmits/scatters the body;
a control unit for controlling operations of the light emitting unit and the light receiving unit;
a signal processing unit for extracting effective data from the second light amount and calculating a blood sugar level by applying a blood sugar model to the effective data; and
and a model generator for generating the blood glucose model.
The method of claim 1,
a storage unit for storing the second light amount and the blood glucose level calculated therefrom;
a display unit for displaying the blood glucose level; and
Non-blood blood glucose meter further comprising a communication unit for transmitting the blood glucose level to the user terminal.
According to claim 1, wherein the light emitting unit,
A first light emitting device for generating a light source in the visible light section, and
A blood glucose meter including second and third light emitting devices for generating light sources of different wavelengths in the near-infrared region.
According to claim 3, wherein the control unit,
A non-blood blood glucose meter that shields the light receiving unit, stops the operation of the light emitting unit, measures the amount of dark light, and sets the first light amount.
According to claim 4, wherein the control unit,
A non-blood blood glucose meter for irradiating the light source by sequentially operating the first to third light emitting devices separately, and measuring a second amount of light corresponding to the light source by the light receiving unit.
According to claim 5, wherein the control unit,
In operating the light emitting unit, at least one mode is used according to a pulse period of the irradiated light source, and the second light amount is measured in each of the modes.
The method of claim 6, wherein the signal processing unit,
A non-blood blood glucose meter for measuring the blood glucose level by extracting the effective data from the second light quantity measured for each mode, respectively, and applying the blood glucose model to the first light quantity and the effective data.
A method for measuring blood glucose using a non-blood glucose meter, the method comprising:
a step of measuring the first amount of light by shielding the light receiving unit;
b step of irradiating at least one light source of near-infrared and visible light to the user's body;
c step of measuring a second amount of each transmitted/scattered light when the light source transmits/scatters the body;
a d step of extracting effective data from the second light amount and calculating a blood sugar level by applying a blood sugar model to the effective data; and
and step e of storing the blood sugar level and the user's unique identification number in a database, and transmitting the blood sugar level to a user terminal.
The method of claim 8, wherein b step,
A blood glucose measurement method in which the light source is divided into at least one mode and irradiated according to a pulse period.
10. The method of claim 9, wherein the c step,
measuring the second amount of light for each of the modes;
extracting the effective data from the light quantity of the transmitted/scattered light measured for each mode;
A blood glucose measurement method for measuring a blood glucose level by applying the blood glucose model to the first light quantity and the at least one valid data.

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