KR20210148320A - 사람 혈청의 존재하에 슈도모나스 아에루기노사에 대해 살균 활성을 갖는 리신 및 이의 유도체 - Google Patents
사람 혈청의 존재하에 슈도모나스 아에루기노사에 대해 살균 활성을 갖는 리신 및 이의 유도체 Download PDFInfo
- Publication number
- KR20210148320A KR20210148320A KR1020217036171A KR20217036171A KR20210148320A KR 20210148320 A KR20210148320 A KR 20210148320A KR 1020217036171 A KR1020217036171 A KR 1020217036171A KR 20217036171 A KR20217036171 A KR 20217036171A KR 20210148320 A KR20210148320 A KR 20210148320A
- Authority
- KR
- South Korea
- Prior art keywords
- ala
- leu
- lysine
- gly
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962830207P | 2019-04-05 | 2019-04-05 | |
| US62/830,207 | 2019-04-05 | ||
| PCT/US2020/026681 WO2020206327A1 (en) | 2019-04-05 | 2020-04-03 | Lysins and derivatives thereof with bactericidal activity against pseudomonas aeruginosa, in the presence of human serum |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20210148320A true KR20210148320A (ko) | 2021-12-07 |
Family
ID=72667504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217036171A Ceased KR20210148320A (ko) | 2019-04-05 | 2020-04-03 | 사람 혈청의 존재하에 슈도모나스 아에루기노사에 대해 살균 활성을 갖는 리신 및 이의 유도체 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220160843A1 (https=) |
| EP (1) | EP3946609A4 (https=) |
| JP (1) | JP2022526978A (https=) |
| KR (1) | KR20210148320A (https=) |
| CN (1) | CN114040773A (https=) |
| AU (1) | AU2020256258A1 (https=) |
| BR (1) | BR112021019430A2 (https=) |
| CA (1) | CA3136126A1 (https=) |
| IL (1) | IL286941A (https=) |
| MX (1) | MX2021012166A (https=) |
| WO (1) | WO2020206327A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU24750B1 (es) * | 2020-11-19 | 2025-06-11 | Centro De Investig Y Desarrollo De Medicamentos Cidem | Entidades peptídicas con actividad antimicrobiana frente a patógenos multi-drogoresistentes |
| CN116200418A (zh) * | 2021-12-01 | 2023-06-02 | 华南农业大学 | 一种筛选铜绿假单胞菌LasR基因调控网络未知基因突变体的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5701777B2 (ja) * | 2009-02-06 | 2015-04-15 | テクノファージ, インベスティガサン エ デセンボルビメント エム ビオテクノロジア,エスエー | 抗菌性ファージ、ファージペプチド、及びそれらの使用方法 |
| CA2833409A1 (en) * | 2011-04-21 | 2012-10-26 | The Rockefeller University | Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria |
| AU2015279705B2 (en) * | 2014-06-26 | 2021-04-01 | The Rockefeller University | Acinetobacter lysins |
| AU2016324307B2 (en) * | 2015-09-17 | 2021-10-21 | Contrafect Corporation | Use of lysin to restore/augment antibacterial activity in the presence of pulmonary surfactant of antibiotics inhibited thereby |
| BR112020011433A2 (pt) * | 2017-12-12 | 2020-12-01 | Contrafect Corporation | identificação de lisinas e seus derivados com atividade bacteriana contra pseudomonas aeruginosa |
| CN108103050A (zh) * | 2018-02-11 | 2018-06-01 | 中国医药集团总公司四川抗菌素工业研究所 | 一种铜绿假单胞菌噬菌体裂解酶、其编码基因、重组表达载体及其制备方法和应用 |
| CN112368376A (zh) * | 2018-03-29 | 2021-02-12 | 康特拉费克特公司 | 溶素-抗微生物肽(amp)多肽构建体、溶素、其分离的编码多核苷酸及其用途 |
| WO2020046747A1 (en) * | 2018-08-23 | 2020-03-05 | Contrafect Corporation | Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
-
2020
- 2020-04-03 EP EP20785056.1A patent/EP3946609A4/en not_active Withdrawn
- 2020-04-03 AU AU2020256258A patent/AU2020256258A1/en not_active Abandoned
- 2020-04-03 JP JP2021559092A patent/JP2022526978A/ja active Pending
- 2020-04-03 MX MX2021012166A patent/MX2021012166A/es unknown
- 2020-04-03 KR KR1020217036171A patent/KR20210148320A/ko not_active Ceased
- 2020-04-03 CA CA3136126A patent/CA3136126A1/en active Pending
- 2020-04-03 WO PCT/US2020/026681 patent/WO2020206327A1/en not_active Ceased
- 2020-04-03 BR BR112021019430A patent/BR112021019430A2/pt not_active IP Right Cessation
- 2020-04-03 CN CN202080041523.4A patent/CN114040773A/zh active Pending
- 2020-04-03 US US17/601,244 patent/US20220160843A1/en not_active Abandoned
-
2021
- 2021-10-04 IL IL286941A patent/IL286941A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2021012166A (es) | 2021-11-03 |
| CA3136126A1 (en) | 2020-10-08 |
| EP3946609A1 (en) | 2022-02-09 |
| EP3946609A4 (en) | 2023-05-03 |
| US20220160843A1 (en) | 2022-05-26 |
| BR112021019430A2 (pt) | 2021-11-30 |
| AU2020256258A1 (en) | 2021-11-04 |
| JP2022526978A (ja) | 2022-05-27 |
| WO2020206327A1 (en) | 2020-10-08 |
| IL286941A (en) | 2021-10-31 |
| CN114040773A (zh) | 2022-02-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7646237B2 (ja) | シュードモナス・エルギノーサに対する殺菌活性を有する溶解素及びその誘導体の特定 | |
| JP7684695B2 (ja) | グラム陰性菌に対して活性を有する溶解素ポリペプチド | |
| CA3095484A1 (en) | Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof | |
| US20220402984A1 (en) | Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof | |
| KR20210024005A (ko) | 스태필로코커스 아우레우스 및 그람 양성 세균을 항생제에 재민감화시키기 위한 리신 및 이의 유도체 | |
| US20210330738A1 (en) | Antimicrobial, bacteriophage-derived polypeptides and their use against gram-negative bacteria | |
| KR20210148320A (ko) | 사람 혈청의 존재하에 슈도모나스 아에루기노사에 대해 살균 활성을 갖는 리신 및 이의 유도체 | |
| KR20230162045A (ko) | 그램-음성 박테리아에 대해 활성인 아무린, 리신, 및 리신-항미생물 펩타이드 (amp) 작제물 | |
| US20220411473A1 (en) | Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof | |
| RU2807688C9 (ru) | Идентификация лизинов и их производных, обладающих антибактериальной активностью против pseudomonas aeruginosa | |
| RU2807688C2 (ru) | Идентификация лизинов и их производных, обладающих антибактериальной активностью против pseudomonas aeruginosa | |
| RU2813626C1 (ru) | Модифицированный эндолизин и антибактериальные композиции на его основе для лечения инфекций, вызванных бактериями Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli | |
| US12384821B2 (en) | Antimicrobial peptides and compositions, methods, articles and kits relating thereto |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| D21 | Rejection of application intended |
Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D21-EXM-PE0902 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| B15 | Application refused following examination |
Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B15-EXM-PE0601 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| PE0601 | Decision on rejection of patent |
St.27 status event code: N-2-6-B10-B15-exm-PE0601 |