KR20210073957A - Cosmetic composition for stabilizing poorly soluble materials - Google Patents

Abstract

The present invention relates to a cosmetic composition for stabilizing poorly soluble substances, wherein the cosmetic composition comprises poorly soluble substances, fatty alcohols, surfactants and auxiliary surfactants.

Description

Cosmetic composition for stabilizing poorly soluble materials {Cosmetic composition for stabilizing poorly soluble materials}

It relates to a cosmetic composition for stabilizing a sparingly soluble substance in a formulation including a sparingly soluble substance, a fatty alcohol, a surfactant, and an auxiliary surfactant.

Centella asiatica consists of Asiaticoside, Madecassic acid, Asiatic acid, etc., Advances in Dermatology and Allergology, 2013, 30(1), 46-49 and According to Journal of Coastal Life Medicine, 2016, 4(12), 1000-1007, etc., it is known to be effective in wound healing, skin soothing, moisturizing, skin barrier improvement, keratin improvement, wrinkle improvement, collagen synthesis, etc. Therefore, various studies are being conducted to use it for purposes such as skin soothing effect, but Centella asiatica is a material that is very difficult to commercialize as it is poorly soluble in water and oil.

According to registered patent 10-0904370, a manufacturing technology for nanoliposomes containing Centella asiatica as an antibacterial cosmetic composition was introduced, but the content is very low (0.01%), and recent trends such as using ethanol, a repellent solvent, are used. There is a problem with the gap. In addition, according to Patent Registration 10-1984192, a technique of stabilizing a core-shell capsule using an amphiphilic polymer was introduced, but a rotary evaporation process of some ethanol and water is required, so the process is very complicated and not easy to commercialize there is In addition, according to Patent No. 10-1509579, a manufacturing technology using a temperature-sensitive polymer and a non-aqueous liquid crystal phase has been introduced, but cooling and post-addition processes are required after the liquid crystal phase is manufactured, and an azimuth mixer and a paddle mixer are required. There is a problem such as this complexity and a lot of manufacturing time is consumed.

Under this background, the present inventors confirmed that it is possible to maximize formulation stability of poorly soluble substances in the cosmetic composition type using fatty alcohols, stearate-based surfactants, glucoside-based surfactants, sorbitan-based surfactants, and auxiliary surfactants. did.

One aspect provides a cosmetic composition for stabilizing a sparingly soluble substance comprising a sparingly soluble substance, a fatty alcohol, a surfactant, and an auxiliary surfactant.

One aspect provides a cosmetic composition for stabilizing a sparingly soluble substance comprising a sparingly soluble substance, a fatty alcohol, a surfactant, and an auxiliary surfactant.

Fatty alcohol, surfactant, and auxiliary surfactant, which are active ingredients of the cosmetic composition, exhibit particle size change, viscosity change, and precipitation of poorly soluble substances even when the cosmetic composition containing the poorly soluble substance is stored at room temperature, high temperature, or frozen for a long time. It is possible to maintain the gloss level of the composition, and in particular, it can help to maintain the skin mimic structure without changing the structure even after long-term storage in the refrigerator.

The sparingly soluble material may be Centella asiatica. The Centella asiatica contains madecassic acid, asiatic acid, asiaticoside, madecassocide, etc. in a certain ratio, and is almost insoluble in water and oil. It is a white to pale yellow solid. In addition, Centella asiatica is known to be effective in promoting collagen synthesis, wound healing, promoting fibroblast proliferation, and alleviating photoaging (Advances in Dermatology and Allergology, 2013, 30(1), 46-49).

The sparingly soluble substance is 0.001 to 20% by weight, for example 0.001 to 18% by weight, for example 0.001 to 16% by weight, for example 0.001 to 14% by weight, for example 0.001 to 12% by weight based on the total weight of the composition %, for example 0.001 to 10% by weight, for example 0.001 to 9% by weight, for example 0.001 to 8% by weight, for example 0.001 to 7% by weight, for example 0.001 to 6% by weight, for example It may be included in an amount of 0.001 to 5% by weight, for example, 0.001 to 4% by weight, for example, 0.001 to 3% by weight, for example, 0.001 to 2% by weight.

The fatty alcohol generally refers to a high molecular weight straight-chain primary alcohol, and may be used interchangeably with a long-chain alcohol. For example, the fatty alcohol may be stearyl alcohol, cetyl alcohol, cetearyl alcohol, myristyl alcohol, caprylic alcohol, lauryl alcohol, decyl alcohol, oleyl alcohol, or a combination thereof.

The fatty alcohol may be present in an amount of 0.1 to 20% by weight, for example 0.1 to 18% by weight, for example 0.1 to 16% by weight, for example 0.1 to 14% by weight, for example 0.1 to 12% by weight, based on the total weight of the composition. , for example 0.1 to 10% by weight, for example 0.1 to 9% by weight, for example 0.1 to 8% by weight, for example 0.1 to 7% by weight, for example 0.1 to 6% by weight, for example 1 to 10% by weight, for example 1 to 9% by weight, for example 1 to 8% by weight, for example 1 to 7% by weight, for example 1 to 6% by weight.

The surfactant may be a stearate-based surfactant, a glucoside-based surfactant, a sorbitan-based surfactant, or a combination thereof. The surfactant is polyglycerol fatty acid esters, sorbitan fatty acid esters, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene alkyl ethers, palm oil fatty acid monoethanolamide, polyoxyethylene cured Castor oil, sodium lauryl sulfate, polyoxyethylene glyceryl pyroglutamic isostearate, sodium alkylbenzenesulfonate, polyoxyethylene stearyl ether, dialkylsulfosuccinic acid, cetylpyridinium bromide, -n-octadecyltrimethyl ammonium chloride, mono alkyl phosphoric acid, N-acyl sultamic acid, N-acyl glutamine, sucrose fatty acid ester, polyoxyethylene sorbitan monostearate, sodium polyoxyethylene lauryl ether sulfate, polyoxyethylene reduced lanolin, sugar ester, and the like.

For example, the stearate-based surfactants include glyceryl stearate, glycerin monostearate, TE stearate, polyoxyethylene (30)-dipolyhydroxystearate, and polyglyceryl 3-dipolyhydroxystearate. Late, isostearylisostearate, polyglyceryl-2-tetraisostearate, polyglyceryl-2-triisostearate, polyglyceryl-4-isostearate, PEG-20-stearate, PEG -40-stearate, PEG-100-stearate, sucrose stearate, or a combination thereof. For example, the glucoside-based surfactant may be cetearyl glucoside, decyl glucoside, coco-glucoside, behenyl alcohol, arachidyl alcohol, arachidyl glucoside, C10-20 alkyl glucoside, or a combination thereof. For example, the sorbitan-based surfactant is sorbitan laurate, sorbitan stearate, sorbitan oleate, sorbitan sesqueoleate, sorbitan tristearate, sorbitan palmitate, sorbitan trioleate, or a combination thereof.

The surfactant is present in an amount of 0.1 to 20% by weight, for example 0.1 to 18% by weight, for example 0.1 to 16% by weight, for example 0.1 to 14% by weight, for example 0.1 to 12% by weight, based on the total weight of the composition. , for example 0.1 to 10% by weight, for example 0.1 to 9% by weight, for example 0.1 to 8% by weight, for example 0.1 to 7% by weight, for example 0.1 to 6% by weight, for example 0.1 to 5% by weight, such as 1 to 10% by weight, such as 1 to 9% by weight, such as 1 to 8% by weight, such as 1 to 7% by weight, such as 1 to 6% by weight; For example, it may be included in 1 to 5% by weight.

The auxiliary surfactant is a monomolecular substance such as niacinamide (Niacinamide), urea (Urea), N,N- diethylnicotinamide (N,N-diethylnicotinamide) and the like; such as polyethylene glycol-block-polypropylene glycol (PEG-b-PPG), polycaprolactone-block-polyethylene glycol (PCL-b-PEG), polypropylene glycol-block-polycaprolactone (PPG-b-PCL), etc. double block copolymer; or polyethylene glycol-block-polypropylene glycol-block-polyethylene glycol (PEG-b-PPG-b-PEG), polyethylene glycol-block-polycaprolactone-block-polyethylene glycol (PEG-b-PCL-b-PEG) , polycaprolactone-block-polyethylene glycol-block-polycaprolactone (PCL-b-PEG-b-PCL), polypropylene glycol-block-polycaprolactone-block-polypropylene glycol (PPG-b-PCL-b -PPG), polycaprolactone-block-polypropylene glycol-block polycaprolactone (PCL-b-PPG-b-PCL), etc.; or a combination thereof.

The auxiliary surfactant is 0.1 to 10% by weight, for example 0.1 to 9% by weight, for example 0.1 to 8% by weight, for example 0.1 to 7% by weight, for example 0.1 to 6% by weight relative to the total weight of the composition %, such as 0.1 to 5% by weight, such as 1 to 10% by weight, such as 1 to 9% by weight, such as 1 to 8% by weight, such as 1 to 7% by weight, such as 1 to 6% by weight, for example, may be included in 1 to 5% by weight.

In one embodiment, Centella asiatica as a sparingly soluble substance; cetearyl alcohol, C14-22 alcohol as fatty alcohol; glyceryl stearate, PEG 100-stearate, alkyl glucoside, hydrogenate lecithin as surfactants; A cosmetic composition containing niacinamide as an auxiliary surfactant was prepared, and as a result of measuring the particle size and viscosity distribution after 12 weeks of storage at room temperature, high temperature, and freezing, immediately after the preparation, the cosmetic composition had a particle size and viscosity change rate of 1 to 10% As a result, it was confirmed that excellent formulation stability was maintained even during long-term storage.

In one embodiment, the skin-mimicking structure of the cosmetic composition was observed using a polarization microscope, and as a result of analysis by X-ray scattering, the cosmetic composition is a liquid crystal emulsion formulation having a multi-layered lamellar structure, and multi-layered even during long-term storage It was confirmed that the lamellar structure could be maintained.

The cosmetic composition may be prepared in any formulation conventionally prepared in the art, and specifically, the cosmetic composition may be a liquid crystal emulsion formulation having a multilayer lamellar structure. The term "liquid crystal" is a term that refers to an intermediate state between a solid and a liquid, and usually has a lamellar structure in which organic molecules having both a hydrophilic part and a lipophilic part are uniformly arranged into a hydrophilic part and a lipophilic part to form several layers. It may mean a generated system. Liquid crystal has both liquid and solid properties, so it shows liquid properties in terms of viscosity and fluidity, and has unique properties that show properties of a solid in terms of physical properties such as light scattering and reflection. It is known that its application range is wide in fields such as the electronics industry. In particular, in the cosmetic field, liquid crystal is formed at the interface during the manufacture of an emulsion to increase the stability of the emulsion, and causes swelling in the emulsion system to increase the viscosity and hardness of the cream or emulsion.

The liquid crystal cosmetic composition may be prepared by a liquid crystal emulsification technique known in the art of conventional cosmetics. For example, the liquid crystal cosmetic composition may be a thermotropic liquid crystal that changes with temperature or a lyotropic liquid crystal that changes with a change in composition, among which the lyotropic liquid crystal is, for example, , a method using a fatty alcohol such as cetearyl alcohol or stearyl alcohol, a method using cholesterol, cholesteryl myristate or ceramide, or a method using a phospholipid such as lecithin may be used.

In one embodiment, the cosmetic composition of the liquid crystal emulsion formulation comprises the steps of: preparing an oil phase by mixing a surfactant and an oil and dissolving by heating at 70 to 80 ° C; preparing an aqueous phase by heating and dissolving polyol and other water-soluble substances and poorly soluble substances (eg, Centella asiatica) in water at 70-80° C.; After adding the oil phase to the aqueous phase, further adding a preservative and stirring; And it may be prepared by a manufacturing method comprising the step of rapidly cooling to about 30 ℃ after the stirring and then defoaming the reactant with a deaerator.

The cosmetic composition may further add components such as antioxidants, preservatives, pH adjusters, humectants, and lubricants as necessary. In addition, the cosmetic 　 composition further includes a substance capable of providing essential nutrients to the skin auxiliary, preferably, a natural fragrance, 　 cosmetic fragrance, or an auxiliary agent including but not limited to plant extracts. It may contain. .

The cosmetic composition according to an aspect maintains the stability in the formulation of Centella asiatica, a poorly soluble material, even when stored at room temperature, low temperature or high temperature by including fatty alcohol, surfactant, and auxiliary surfactant, thereby soothing the skin, moisturizing, and healing wounds. , collagen synthesis, etc. can be maximized.

The cosmetic composition according to an aspect contains Centella asiatica, a sparingly soluble material, in a skin-friendly multi-lamellar liquid crystal formulation, so that precipitation does not occur.

1 is a graph showing the particle size distribution immediately after preparation of the compositions of Comparative Examples 1 and 1 and after freezing for 12 weeks.
Figure 2 is an image observed with a polarizing microscope immediately after the preparation of the composition of Example 1 and after 12 weeks of freezing and storage of the skin mimicking structure.
3 is a graph analyzed by small-angle X-ray scattering (SAXS) of the lamellar layer structure immediately after preparation of the composition of Example 1 and after freezing for 12 weeks.

Hereinafter, it will be described in more detail through examples. However, these examples are for illustrative purposes only, and the scope of the present invention is not limited to these examples.

Comparative Example 1 and Examples 1 to 4. Preparation of general oil-in-water emulsion containing poorly soluble substances, and liquid crystal emulsion

A general oil-in-water emulsion of Comparative Example 1 and liquid crystal emulsions of Examples 1 to 4 containing Centella asiatica, a poorly soluble substance, were prepared. Specific compositions of Comparative Example 1 and Examples 1 to 4 are shown in Table 1 below.

ingredient Comparative Example 1 Example 1 Example 2 Example 3 Example 4 1. D.I. water To 100 To 100 To 100 To 100 To 100 2. Glycerin 2.00 2.00 2.00 2.00 2.00 3. Butylene glycol 5.00 5.00 5.00 5.00 5.00 4. Dipropylene glycol 10.0 10.0 10.0 10.0 10.0 5. Triethanolamine 0.10 0.10 0.10 0.10 0.10 6. EDTA-2Na 0.02 0.02 0.02 0.02 0.02 7. Carbomer 0.12 0.12 0.12 0.12 0.12 8. Niacinamide - 2.00 - - 5.00 9. Centella Asiatica 1.00 1.00 1.00 1.00 1.00 10. Caprylic/capric triglycerides 5.00 5.00 5.00 5.00 5.00 11. Squalane 5.00 5.00 5.00 5.00 5.00 12. Cetearyl alcohol - 4.00 4.00 4.00 4.00 13. C14-22 alcohol - 1.00 1.00 1.00 1.00 14. Glyceryl stearate 1.00 1.00 - 1.00 1.00 15. PEG 100-stearate 1.00 1.00 - 1.00 1.00 16. Alkyl glucoside - 2.00 2.00 2.00 2.00 17. Hydrogenated lecithin - 0.10 0.10 0.10 0.10 18. Preservatives q.s. q.s. q.s. q.s. q.s. 19. Perfume 0.10 0.10 0.10 0.10 0.10

In Table 1, 1 to 8 are water-soluble components, of which 2 to 4 are polyols, 5 is a pH adjusting agent, 6 is a sequestering agent, 7 is a viscosity adjusting agent, 8 is an auxiliary surfactant, and 9 is an egg. Centella asiatica is a soluble active ingredient, 10 to 17 are oil-soluble ingredients, of which 12 and 13 are fatty alcohols, 14 to 17 are surfactants, 18 are preservatives, and 19 are fragrance ingredients.

An oily solution was prepared by mixing Centella asiatica with oil-soluble components including fatty alcohol and surfactant, and dissolving by heating at 70 ~ 80 °C. An aqueous solution was prepared by mixing the water-soluble components of Table 1 in a separate container and dissolving by heating at 80 to 90 °C. The oil phase solution was slowly added to the aqueous phase solution and stirred with a homomixer. The stirred mixed solution was cooled to 50 °C, a preservative and fragrance were added, and the mixture was stirred with a homomixer. Then, it was rapidly cooled to 30 ° C. and then defoamed to prepare a general oil-in-water and liquid crystal emulsion cosmetic composition containing a sparingly soluble substance.

Experimental Example 1. Measurement of particle size distribution

The particle size distribution of the compositions of Comparative Example 1 and Examples 1 to 4 was repeated three times immediately after preparation using a particle size analyzer (LA-960, Horiba, Japan), room temperature 12 weeks, 45° C. 12 weeks, and freezing 12 weeks. were measured, and the average value was calculated. Specifically, 50 μg of each sample is placed in a sample bottle, diluted 50-fold with distilled water, and dispersed for 5 minutes with an ultrasonic device. The sample was slowly added to the chamber according to the particle size analyzer usage, and the permeability was measured when the transmittance was 80 to 90%, and the particle size change rate was calculated immediately after preparation and after 12 weeks of freezing.

As a result, the average particle size distribution value according to the particle size measurement time is shown in Table 2 below. In addition, the particle size distribution diagrams immediately after the preparation of Comparative Examples 1 and 1 and after 12 weeks of freezing are shown in FIG. 1 .

Comparative Example 1 Example 1 Example 2 Example 3 Example 4 immediately after manufacturing 4.126 μm 9.914 μm 12.750 μm 10.507 μm 6.845 μm room temperature 12 weeks 10.907 μm 10.143 μm 15.133 μm 11.935 μm 7.043 μm 45℃ 12 weeks 9.032 μm 10.106 μm 13.818 μm 11.264 μm 6.998 μm frozen 12 weeks 13.322 μm 10.633 μm 16.022 μm 13.414 μm 7.337 μm

As a result, as shown in FIG. 1 and Table 2, the composition of Comparative Example 1 is about when the particle size is measured after 12 weeks at room temperature, 12 weeks at 45° C., or 12 weeks after freezing compared to immediately after preparation. increased by 2 to about 3.5 times, a large change in the particle size distribution value was shown, whereas the compositions of Examples 1 to 4 were prepared after 12 weeks at room temperature, 12 weeks at 45° C., or 12 weeks at frozen compared to immediately after preparation. Since it does not show a significant difference from the week after week, it can be seen that the change in the particle size distribution value is remarkably small.

Accordingly, the particle size change rate calculated using Equation 1 below is shown in Table 3 below.

[Equation 1]

Comparative Example 1 Example 1 Example 2 Example 3 Example 4 room temperature 12 weeks 164.35% 2.31% 18.69% 13.59% 2.89% 45℃ 12 weeks 118.90% 1.94% 8.38% 7.20% 2.24% frozen 12 weeks 222.88% 7.25% 25.66% 27.67% 7.19%

As a result, as shown in Table 3, the composition of Comparative Example 1 exhibited a very high rate of change in particle size, but the compositions of Examples 1 to 4 exhibited a significantly lower rate of change in particle size. In particular, the compositions of Examples 1 and 4 further comprising niacinamide as an auxiliary surfactant showed a lower particle size change rate compared to the compositions of Examples 2 and 3.

From the above results, the compositions of Examples 1 to 4 include fatty alcohol, a stearate-based surfactant, a glucoside-based surfactant, and a sorbitan-based surfactant, and in particular, the compositions of Examples 1 and 4 further include an auxiliary surfactant By doing so, since the composition does not show a change in particle size even after storage at room temperature, high temperature, or frozen, it can be confirmed that the stability in the formulation of Centella asiatica, a sparingly soluble material, is significantly improved.

Experimental Example 2. Confirmation of precipitation and gloss

In order to evaluate the stability in the formulation of the composition of Comparative Example 1 and Examples 1 to 4 of the sparingly soluble material, the precipitation phenomenon and the glossiness were evaluated. The evaluation criteria for precipitation are as follows: ○: with precipitation; △: surface instability; X: No precipitation. Evaluation criteria for the degree of gloss are as follows: ○: glossy; △: surface instability; X: No gloss. The evaluation results are shown in Table 4 below.

Experimental items Comparative Example 1 Example 1 Example 2 Example 3 Example 4 precipitation immediately after manufacturing X X X X X room temperature 12 weeks O X △ X X 45℃ 12 weeks X X X X X frozen 12 weeks O X △ △ X Polish immediately after manufacturing O O O O O room temperature 12 weeks △ O △ △ O 45℃ 12 weeks △ O O O O frozen 12 weeks △ O X △ O

As a result, as shown in Table 4, the composition of Comparative Example 1 showed a precipitation phenomenon after 12 weeks at room temperature and 12 weeks at room temperature, whereas the compositions of Examples 1 to 4 showed 12 weeks at room temperature, 12 weeks at 45 °C, and Precipitation phenomenon was hardly observed after 12 weeks of freezing, and in particular, the compositions of Examples 1 and 4 further comprising an auxiliary surfactant did not exhibit any precipitation phenomenon regardless of the storage period and temperature.

In addition, the composition of Comparative Example 1 had an unstable surface and did not show gloss after 12 weeks at room temperature, 12 weeks at 45°C, and 12 weeks at 45°C, but Example 1 further comprising an auxiliary surfactant among the compositions of Examples 1 to 4 And the composition of 4 showed gloss regardless of the storage period and temperature.

From the above results, the compositions of Examples 1 to 4 include fatty alcohol, a stearate-based surfactant, a glucoside-based surfactant, and a sorbitan-based surfactant, and in particular, the compositions of Examples 1 and 4 further include an auxiliary surfactant By doing so, it can be confirmed that the precipitation phenomenon does not appear even after storage at room temperature, high temperature, and frozen, and the gloss level is maintained, so that the stability in the formulation of Centella asiatica, which is a poorly soluble material, is remarkably improved.

Experimental Example 3. Viscosity Measurement

The viscosity of the compositions of Comparative Example 1 and Examples 1 to 4 was measured using a viscometer (DV2T-LV, Brookfield, Canada) immediately after preparation, room temperature 12 weeks, 45° C. 12 weeks, and freezing 12 weeks. Specifically, the viscosity was measured within a rotational speed of 10 to 15 rpm in a state in which the 63 and 64 rotating mandrels were in contact with the sample according to the viscosity. As a result, the viscosity values according to the viscosity measurement time are shown in Table 5 below.

Viscosity measurement Comparative Example 1 Example 1 Example 2 Example 3 Example 4 immediately after manufacturing 3,740 cP 32,700 cP 33,450 cP 28,800 cP 25,400 cP room temperature 12 weeks 5,770 cP 33,700 cP 39,750 cP 33,700 cP 25,950 cP 45℃ 12 weeks 6,120 cP 33,800 cP 35,900 cP 30,500 cP 26,050 cP frozen 12 weeks 7,320 cP 33,850 cP 42,050 cP 34,950 cP 26,400 cP

As a result, as shown in Table 5, the composition of Comparative Example 1 had a very large viscosity change of 100% or more after 12 weeks at room temperature, 12 weeks at 45°C, and 12 weeks at 45° C., whereas Examples 1 to The composition of 4 showed a significantly lower level of viscosity change. In particular, the compositions of Examples 1 and 4 further comprising niacinamide as an auxiliary surfactant showed a low viscosity change rate of 5 to 10% compared to the compositions of Examples 2 and 3 as well.

From the above results, the compositions of Examples 1 to 4 include fatty alcohol, a stearate-based surfactant, a glucoside-based surfactant, and a sorbitan-based surfactant, and in particular, the compositions of Examples 1 and 4 further include an auxiliary surfactant By doing so, it can be confirmed that the stability in the formulation of Centella asiatica, which is a sparingly soluble substance, is remarkably improved because it shows a low viscosity change even after storage at room temperature, high temperature, and frozen.

Experimental Example 4. Analysis of skin-simulating structure

In order to evaluate the stability in the formulation of the poorly soluble material in the composition of Example 1, the structure of the skin mimicked immediately after preparation and 12 weeks after freezing was observed through a polarizing microscope, and the ratio of small-angle X-ray scattering peaks was analyzed. According to the Bragg spacing ratio, when the ratio of small-angle X-ray scattering peaks is 1: 2: 3, it can be seen as a lamellar structure.

As a result, as shown in FIG. 2, the composition of Example 1 was a liquid crystal emulsion having a stable multilayer lamellar structure, and it was confirmed that the liquid crystal phase was generated and maintained immediately after preparation and after storage for 12 weeks in the freezer.

In addition, as shown in FIG. 3, when analyzing the graph of small-angle X-ray scattering analysis immediately after preparation of the composition of Example 1 and 12 weeks after freezing, the ratio of q values immediately after preparation is 0.0296: 0.0592: 0.0888 (about 1: 2: 3 ) was confirmed to have a lamellar structure, and even after 12 weeks of freezing, 0.0250: 0.0500: 0.0750 (about 1: 2: 3) was confirmed to have a lamellar structure.

From the above results, the composition of Example 1 contains a fatty alcohol, a stearate-based surfactant, a glucoside-based surfactant, a sorbitan-based surfactant, and an auxiliary surfactant. can confirm that it can be maintained.

Claims (8)

A cosmetic composition comprising a sparingly soluble substance, a fatty alcohol, a surfactant, and an auxiliary surfactant. The cosmetic composition according to claim 1, wherein the sparingly soluble substance is Centella asiatica. The cosmetic composition according to claim 1, wherein the fatty alcohol is stearyl alcohol, cetyl alcohol, cetearyl alcohol, myristyl alcohol, caprylic alcohol, lauryl alcohol, decyl alcohol, oleyl alcohol, or a combination thereof. . The cosmetic composition of claim 1, wherein the surfactant is a stearate-based surfactant, a glucoside-based surfactant, a sorbitan-based surfactant, or a combination thereof. The method according to claim 1, wherein the auxiliary surfactant is niacinamide (Niacinamide), urea (Urea), N,N- diethylnicotinamide (N,N-diethylnicotinamide), polyethylene glycol-block- polypropylene glycol (PEG-b- PPG), polycaprolactone-block-polyethylene glycol (PCL-b-PEG), polypropylene glycol-block-polycaprolactone (PPG-b-PCL), polyethylene glycol-block-polypropylene glycol-block-polyethylene glycol ( PEG-b-PPG-b-PEG), polyethylene glycol-block-polycaprolactone-block-polyethylene glycol (PEG-b-PCL-b-PEG), polycaprolactone-block-polyethylene glycol-block-polycaprolactone (PCL-b-PEG-b-PCL), polypropylene glycol-block-polycaprolactone-block-polypropylene glycol (PPG-b-PCL-b-PPG), polycaprolactone-block-polypropylene glycol-block Polycaprolactone (PCL-b-PPG-b-PCL), or a cosmetic composition of a combination thereof. The cosmetic composition of claim 1, wherein the composition comprises 0.001 to 10% by weight of a sparingly soluble substance, 0.1 to 10% by weight of a fatty alcohol, 0.1 to 10% by weight of a surfactant, and 0.1 to 10% by weight of an auxiliary surfactant, based on the total weight of the composition. The cosmetic composition according to claim 1, wherein the rate of change in viscosity or particle size after storage for 1 to 20 weeks is 1 to 10% compared to the viscosity or particle size immediately after preparation of the composition. The cosmetic composition according to claim 1, which is a liquid crystal emulsion formulation having a multilayer lamellar structure.

Images