KR20210056212A - Method, apparatus and system for X-ray images acquisition and processing using hybrid pulses - Google Patents

Abstract

The present invention relates to a method, an apparatus and a system for acquiring and processing an X-ray image and, more specifically, to a method, an apparatus and a system for acquiring and processing an X-ray image using a hybrid pulse, which can use the hybrid pulse with sequential emission of an ultra-short pulse (USP) and a coded pulse (CP) to effectively prevent the deterioration of the quality of X-ray image such as motion blur caused by the motion of a subject in the image. According to the present invention, a method for generating, by an X-ray image generation system, the X-ray image for the subject comprises: an X-ray emission step of controlling an X-ray source to sequentially emit, to the subject, X-rays of the USP and the CP in which a waveform takes the predetermined code form, wherein the USP is emitted for a shorter time than the CP; a reference image generation step of generating a reference image by detecting the X-ray of the USP which has passed through the subject; a code motion blur image generation step of generating a code motion blur image by detecting the X-rays of the CP which has passed through the subject; and an X-ray image generation step of generating a deblurred X-ray image with respect to the code motion blur image by using the reference image and the code motion blur image.

Description

[Method, apparatus and system for X-ray images acquisition and processing using hybrid pulses}

The present invention relates to a method, apparatus, and system for acquiring and processing an X-ray image, and more specifically, a motion of an object in an image using a hybrid pulse in which an ultra short pulse and a coded pulse are sequentially irradiated. A method, apparatus, and system for obtaining and processing an X-ray image using hybrid pulses capable of effectively improving the quality deterioration of an X-ray image such as motion blur according to ).

Conventionally, an image-based diagnosis method using X-rays or the like has been widely used, and various X-ray devices for this have been developed and used widely.

More specifically, an X-ray source used in an X-ray apparatus may be divided into an analog X-ray source and a digital X-ray source. Here, the analog X-ray source is a method of generating hot electrons by heating an electron source such as a tungsten filament at a high temperature and colliding the emitted electrons with the target, and the digital X-ray source is an Emmy It uses a method of generating X-rays by applying a high-voltage current to the generator (cathode) and colliding the emitted electrons with the target.

In addition, in order to implement an X-ray source in general, a high-brightness, high-current electron source is required. In particular, a digital X-ray source has a smaller amount of radiation than an analog method, has excellent image quality, and is capable of continuous shooting and miniaturization. Due to its advantages, many studies have been conducted.

More specifically, with regard to digital X-ray sources, the Carbon Nano-Tube (CNT) method has problems such as defects in the atomic structure, deterioration or destruction due to low vacuum degree, and is a major obstacle in the actual device application stage. In order to solve such a problem, research to apply a new cathode technology having long life and high stability output by improving the wear resistance and heat dissipation properties of the emitter (cathode) is also underway.

In addition, in a conventional X-ray-based imaging system, various types of motion may occur in the process of acquiring an image using techniques such as Fluoroscopy, Computed Tomography (CT), and Tomosynthesis. Accordingly, there may be a problem in that the quality of the X-ray image is deteriorated due to motion blur occurring in the image data.

More specifically, as a problem due to the motion blur, the high frequency characteristics of the X-ray image (for example, edges in the image) may be crushed, and the motion that causes such motion blur. Types of the patient/tissue movements (eg, heart, respiratory movements, etc.), instrument movements in the X-ray imaging system, detector movements, gantry movements, and movements of X-ray sources.

Accordingly, various techniques have been tried to improve motion blur of X-ray images in the past, but these techniques extend image acquisition time, add mechanical devices for image processing, increase image noise, and/or during image processing. There were problems such as loss of image information.

On the other hand, General Electric Company has proposed a method of applying a coded exposure technique to radiography, as shown in FIG. 1.

However, even in the prior art as described above, the motion that causes the motion blur of the X-ray image is limited to the extent that the user directly measures and inputs the motion that causes the motion blur or is calculated using an electrocardiogram, etc. It was difficult to accurately reflect the direction, speed, and trajectory of X-rays, and accordingly, there was a limitation in that the motion blur of the X-ray image could not be effectively corrected.

US patent publication US9194965 (2012.11.24)

The present invention was invented to solve the problems of the prior art, and is capable of effectively correcting the motion blur of the X-ray image by automatically accurately grasping the motion that causes the motion blur of the X-ray image. It is aimed at.

In addition, an object of the present invention is to increase the convenience of use by automatically obtaining a point spread function (PSF) for motion blur of the X-ray image.

Further, an object of the present invention is to calculate a high-precision motion point spread function (PSF) according to motion in the X-ray image to effectively improve the quality of an X-ray image, such as reconstructing a high-quality, high-resolution image.

In the method of generating an X-ray image according to an embodiment of the present invention, in a method of generating an X-ray image of an object by an X-ray image generating system, an X-ray source is controlled to transmit an ultra short pulse (USP) to the object, An X-ray irradiation step of sequentially irradiating X-rays of coded pulses (CP) whose waveforms form a predetermined code (here, the first short pulse is irradiated for a shorter time than the code pulse); A reference image generating step of generating a reference image by detecting X-rays of the ultrashort pulses that have passed through the object; Generating a coded motion blur image by detecting X-rays of the code pulses passing through the object; And generating an X-ray image deblurred with respect to the code motion blur image by using the reference image and the code motion blur image.

In this case, in the step of generating the X-ray image, a motion blur point spread function is calculated for calculating a motion blur point spread function corresponding to the motion in the image of the object from the reference image and the code motion blur image. step; And generating an X-ray image deblurred with respect to the code motion blur image using the motion blur point spread function.

Further, in the X-ray irradiation step, after irradiating the ultrashort pulse in a first exposure period, the code pulse may be irradiated in a second exposure period following the first exposure period.

Further, the calculating of the motion blur point spreading function may include: calculating a blur direction of the object using the reference image and the code motion blur image; And calculating a blur size of the object using the reference image and the code motion blur image.

Here, in the step of calculating the blur direction, the blur direction of the object may be calculated using a fast Fourier transform (FFT) of the reference image and the code motion blur image.

In addition, in the blur size calculation step, after calculating a plurality of candidate blur images using the reference image for a plurality of predetermined blur size candidate values, the similarity with the code motion blur image is compared, You can calculate the blur size.

In addition, in the calculating of the motion blur point spreading function, a motion blur point spreading function for the object may be calculated from the reference image and the code motion blur image using a machine-learned first neural network circuit.

In addition, the generating of the X-ray image may include calculating a code point spread function for the code pulse CP; Calculating a combined point spread function in which the code point spread function and the motion blur point spread function are combined; And performing deblurring on the code motion blur image using the combined point spread function.

In addition, in the X-ray irradiation step, after irradiating the code pulse in a second exposure period, a second ultrashort pulse may be further irradiated in a third exposure period following the second exposure period.

Here, in the step of generating the X-ray image, a virtual reference image at an arbitrary point in the second exposure period is calculated through interpolation of the reference image and the second reference image by the second ultrashort pulse. , An X-ray image deblurred with respect to the blur image may be generated using the virtual reference image.

Further, in the X-ray irradiation step, after irradiating the ultrashort pulse in a first exposure period and reading detected X-ray data only for a predetermined region of interest (ROI), the code pulse is irradiated in the second exposure period, and the The time interval between the first exposure period and the second exposure period may be minimized.

In addition, a test image step of calculating a code pulse CP corresponding to the motion of the object by estimating the motion of the object from a preshot X-ray image of the object may be further included.

In addition, an X-ray image generating system according to another embodiment of the present invention is an X-ray image generating system for generating an X-ray image of an object, comprising: an X-ray source emitting X-rays; An X-ray detector configured to detect X-rays transmitted through the object; A control unit for controlling to sequentially irradiate X-rays of an ultra short pulse (USP) and a coded pulse (CP) having a shape of a predetermined code from the X-ray source to the object (here, the ultra short pulse) Is irradiated for a shorter time than the code pulse); And an X-ray image deblurred with respect to the code motion blur image using a reference image generated from the X-ray of the ultrashort pulse and a coded motion blur image generated from the X-ray of the code pulse. It characterized in that it comprises a; X-ray image generator for generating.

Accordingly, in the method, apparatus, and system for acquiring and processing an X-ray image using a hybrid pulse according to an embodiment of the present invention, a motion that causes motion blur of an X-ray image is accurately identified and a motion blur point corresponding thereto. By allowing automatic acquisition of the Motion Blur Point Spread Function, convenience of use is increased, and the high-precision motion point spread function (PSF) is calculated to effectively improve the quality of X-ray images such as high-quality, high-resolution image restoration. do.

Accordingly, in the method, apparatus, and system for acquiring and processing an X-ray image using a hybrid pulse according to an embodiment of the present invention, a motion that causes motion blur of an X-ray image is accurately identified and a motion blur point corresponding thereto. By allowing automatic acquisition of the Motion Blur Point Spread Function, convenience of use is increased, and the high-precision motion point spread function (PSF) is calculated to effectively improve the quality of X-ray images such as high-quality, high-resolution image restoration. do.

The present invention may apply various transformations and may have various embodiments. Hereinafter, specific embodiments will be described in detail based on the accompanying drawings.

The following examples are provided to aid in a comprehensive understanding of the methods, apparatus and/or systems described herein. However, this is only an example and the present invention is not limited thereto.

In describing the embodiments of the present invention, when it is determined that a detailed description of a known technology related to the present invention may unnecessarily obscure the subject matter of the present invention, a detailed description thereof will be omitted. In addition, terms to be described later are terms defined in consideration of functions in the present invention, which may vary according to the intention or custom of users or operators. Therefore, the definition should be made based on the contents throughout the present specification. The terms used in the detailed description are only for describing the embodiments of the present invention, and should not be limiting. Unless explicitly used otherwise, expressions in the singular form include the meaning of the plural form. In the present description, expressions such as "comprising" or "feature" are intended to refer to certain features, numbers, steps, actions, elements, some or combination thereof, and one or more It should not be construed to exclude the presence or possibility of other features, numbers, steps, actions, elements, any part or combination thereof.

In addition, terms such as first and second may be used to describe various components, but the components are not limited by the terms, and the terms are used to distinguish one component from other components. Is only used.

Hereinafter, exemplary embodiments of a method, apparatus, and system 100 for generating an X-ray image according to an exemplary embodiment will be described with reference to the accompanying drawings.

First, FIG. 2 shows a flowchart of a method of generating an X-ray image according to an embodiment of the present invention.

In this case, as shown in FIG. 2, in the method of generating an X-ray image according to an exemplary embodiment of the present invention, the X-ray image generating system 100 generates an X-ray image of the object A. 110) to sequentially irradiate X-rays of an ultra short pulse (USP) and a coded pulse (CP) having a shape of a predetermined code to the object A (here , The first short pulse is irradiated for a shorter time than the code pulse) (S10), a reference image generation step of generating a reference image by detecting X-rays of the first short pulse transmitted through the object A (S20) ), generating a coded motion blur image by detecting X-rays of the code pulses passing through the object A (S30), and the reference image and the coded motion blur image By using, an X-ray image generation step S40 of generating an X-ray image deblurred with respect to the code motion blur image may be included.

In addition, FIG. 3 illustrates a configuration diagram of an X-ray image generating system 100 according to an embodiment of the present invention.

In this case, as can be seen in FIG. 3, the X-ray image generating apparatus 100 according to an exemplary embodiment of the present invention is an X-ray image generating system 100 that generates an X-ray image of an object A. An X-ray source 110 that emits, an X-ray detector 130 that detects X-rays that have passed through the object A, an ultra short pulse (USP) from the X-ray source 110 to the object A, and A control unit for controlling to sequentially irradiate X-rays of coded pulses (CP) whose waveforms form a predetermined code (here, the first short pulse is irradiated for a shorter time than the code pulse) 120; And an X-ray image deblurred with respect to the code motion blur image using a reference image generated from the X-ray of the ultrashort pulse and a coded motion blur image generated from the X-ray of the code pulse. It may be configured to include an X-ray image generator 140 that generates.

Accordingly, in the X-ray image acquisition and processing method, apparatus, and system 100 using a hybrid pulse according to an embodiment of the present invention, a motion that causes motion blur of an X-ray image is accurately identified. And, by deblurring the X-ray image by automatically acquiring the corresponding Motion Blur Point Spread Function, the convenience of use is increased and the high-precision motion point spread function (PSF) is calculated to provide high quality and high resolution. It is possible to effectively improve the quality of an X-ray image, such as image restoration.

Hereinafter, a method of acquiring and processing an X-ray image using a hybrid pulse, an apparatus and a system 100 using a hybrid pulse according to an exemplary embodiment of the present invention will be divided into components and examined in more detail with reference to FIGS. 2 and 3.

First, in the X-ray irradiation step (S10), the controller 120 controls the X-ray source 110 to transmit an ultra short pulse (USP) to the object A, and a waveform in the form of a predetermined code. The X-rays of the coded pulses (CP) constituting the are sequentially irradiated.

In this case, the first short pulse USP is irradiated for a shorter time than the code pulse CP in the first exposure period. More specifically, as can be seen in FIG. 4, the ultra-short pulse (for example, USP_1 in FIG. 4) is a blur caused by the movement of the object A in a reference image generated by detecting the X-ray of the ultra-short pulse. It is preferable to irradiate the ultrashort pulse for a sufficiently short time (even if noise or the like occurs) so that (Blur) can be suppressed.

In addition, the control unit 120 irradiates the first pulse to the object A in the first exposure period, and then, as shown in FIG. 4, the code pulse in which the waveform forms a predetermined code in the second exposure period. (For example, CP_1 of FIG. 4) may be irradiated to the object A.

Further, in the method, apparatus, and system 100 for obtaining and processing an X-ray image using a hybrid pulse according to an embodiment of the present invention, the X-ray source 110 is in the form of a predetermined code as shown in FIG. 4. Although it is preferable that it is a digital X-ray source capable of irradiating X-rays, the specific type or structure of the X-ray source 110 is not limited in the present invention.

In addition, as can be seen in FIG. 4, after irradiating the code pulse to the object A in a second exposure period, the control unit 120 performs a second exposure period in a third exposure period following the second exposure period. An ultra-short pulse may be additionally irradiated to the object A.

Further, in the present invention, prior to the X-ray irradiation step (S10), a motion of the object is estimated from a preshot X-ray image of the object A to correspond to the motion of the object A. It may further include a test image step of calculating the code pulse CP. Accordingly, in the present invention, a series of steps may be performed after using the optimal code pulse CP in consideration of the movement of the object A.

In addition, in the reference image generation step S20, the X-ray detector 130 detects the X-ray of the ultrashort pulse that has passed through the object A to generate a reference image.

At this time, since the first short pulse is irradiated only for a short period of time, noise may occur in the reference image generated by detecting the first short pulse, but an X-ray image in which blur caused by the movement of the object A is suppressed is obtained. You will be able to.

In addition, in the coded motion blur image generation step (S30), the X-ray detector 130 detects X-rays of the code pulses that have passed through the object A to generate a coded motion blur image. do.

At this time, as can be seen in FIG. 4, since the code pulse is irradiated for a considerable period of time, the X-ray image (= code motion blur image) generated by detecting the code pulse has a motion blur due to the movement of the object A ( motion blur) may appear.

Furthermore, motion blur in the coded motion blur image is not only the movement of the object A (for example, movement of the heart, respiratory tract, etc.), but also the X-ray source 110 of the X-ray image generating system 100 ), movement of the X-ray detector 130, the gantry, and other various devices.

In addition, as can be seen in FIG. 5, in the case of detecting X-rays continuously irradiated by the X-ray detector 130 while continuously irradiating X-rays from the X-ray source 110 (Fig. 5 (a1)) according to the prior art ( 5(a2)), since zero-crossing may appear at a specific frequency of the X-ray image, efficient deblurring may be difficult, but in the case of the present invention, in the X-ray source 110 When the code pulse forming a predetermined code shape is irradiated (FIG. 5(b1)), and the X-ray detector 130 detects the X-ray of the code pulse (FIG. 5(b2)), zero in the X-ray image -Since zero-crossing can be suppressed, efficient deblurring is possible.

Subsequently, in the X-ray image generating step (S40), the X-ray image generator 140 uses the reference image and the code motion blur image, as shown in FIG. 6, the code motion blur image (for example, For example, an X-ray image deblurred with respect to (a) of FIG. 6 is generated (eg, (b) of FIG. 6).

More specifically, in the step of generating the X-ray image (S40), as shown in FIG. 7, a motion blur point corresponding to a motion in the image of the object A is spread from the reference image and the code motion blur image. The code motion blur image is deblurred using the motion blur point spread function calculation step (S41) of calculating a motion blur point spread function and the motion blur point spread function. It may include an X-ray image generating step (S42) of generating an X-ray image.

In this case, the motion blur point spreading function models a blur caused by motion of the object A, etc., and may be implemented in a matrix form for an X-ray image having a form of a two-dimensional array. , The present invention is not necessarily limited thereto.

In addition, in the present invention, the code blur point spread function refers to a point spread function according to the code shape of the code pulse, and is applied to an X-ray image having a form of a two-dimensional array like the motion blur point spread function. On the other hand, it may be implemented in a matrix form, but the present invention is not necessarily limited thereto.

Further, in the present invention, the combined point spreading function models the shape of the code pulse in the coded motion blur image and motion blur according to the movement of the object A, etc. Likewise, an X-ray image having a two-dimensional array may be implemented in a matrix form, but the present invention is not limited thereto.

Accordingly, in the method, apparatus, and system 100 for obtaining and processing an X-ray image using a hybrid pulse according to an embodiment of the present invention, a motion blur point spread function corresponding to a motion in the image of the object A and X-rays deblurred through a technique such as matrix inversion on the code motion blur image after obtaining a code point spreading function according to the shape of the code pulse and combining the combined point spreading function You can create an image.

Further, in the motion blur point spreading function calculation step (S41), as shown in FIG. 8, a blur direction calculation for calculating a blur direction of the object A using the reference image and the code motion blur image Step S411 and a blur size calculation step S412 of calculating a blur size of the object A using the reference image and the code motion blur image.

In this case, in the calculating of the blur direction (S411), the blur direction of the object may be calculated using a fast Fourier transform (FFT) of the reference image and the code motion blur image.

For a more specific example, in the blur direction calculation step (S411), first, a two-dimensional fast Fourier transform (2D FFT) matrix is calculated and stored for a reference image by the ultrashort pulse (USP) (FFT_USP), After calculating a two-dimensional fast Fourier transform (2D FFT) matrix for the code motion blur image by the code pulse (CP) and storing it (FFT_CP), {Conjugate of FFT_USP x FFP_CP} / {Conjugate of FFT_USP x FFP_USP} It is possible to calculate the blur direction of the target value A through an inverse fast Fourier transform (IFFT) for the result value.

Further, in the blur size calculation step (S412), after calculating a plurality of candidate blur images using the reference image for a plurality of predetermined blur size candidate values, image similarity with the code motion blur image measure) to calculate the blur size of the object (in proportion to the moving speed of the object A).

Accordingly, in the generating of the X-ray image (S40), the motion blur point spreading function may be calculated in consideration of the calculated blur direction and blur size.

Further, in the motion blur point spread function calculation step (S41), a motion blur point spread function for the object A is calculated from the reference image and the code motion blur image using a machine-learned first neural network circuit. It is also possible to do it.

In this case, it is possible to use a generally well-known U-net structure or the like as the first neural network circuit, but the present invention is not necessarily limited thereto.

Accordingly, the first neural network circuit may be configured to receive a reference image based on the first short pulse and a code motion blur image based on the code pulse and output a motion blur point spread function for the object A.

In addition, in the method, apparatus, and system 100 for acquiring and processing an X-ray image using a hybrid pulse according to an embodiment of the present invention, the step of generating the X-ray image (S40) includes the code Calculating a code point spread function for a pulse CP (S43), the code point spread function and the motion blur point spread function It may include calculating a combined combined point spreading function (S44) and performing deblurring on the code motion blur image using the combined point spreading function (S45).

Here, in step S43, a code point spread function for the code pulse CP is calculated.

In this case, as can be seen in FIG. 10, it is preferable to use the optimal code pulse CP selected in consideration of the movement of the object A among several code pulses prepared in advance. .

Accordingly, in step S43, a code point spread function corresponding to the selected code pulse CP is calculated.

Next, in step S44, a combined point spreading function in which the motion blur point spreading function calculated in advance and the code point spreading function are combined is calculated.

For a more specific example, when the motion blur point spreading function and the code point spreading function are each implemented in a matrix form, the combined point spreading function may be calculated by multiplying each matrix.

Subsequently, in step S45, deblurring is performed on the code motion blur image using the combined point spread function.

For a more specific example, when the coupling point spreading function is implemented in a matrix form, a deblurred X-ray image is calculated for the code motion blur image through a matrix inversion technique.

Further, in the X-ray image generation step (S40), a virtual reference image at a certain point in the second exposure period through interpolation with respect to the reference image and the second reference image by the second ultrashort pulse May be calculated, and an X-ray image deblurred with respect to the blur image may be generated using the virtual reference image.

That is, as shown in Fig. 4, since the reference image by the first short pulse is generated with a certain time difference from the code motion blur image by the code pulse (Δt in Fig. 4), the error due to the time difference is reduced. In order to generate a virtual reference image in the second exposure period in which the code motion blur image is generated by using interpolation between the reference image and the second reference image, Deblurring can be performed.

In addition, in the present invention, it is possible to calculate the motion blur direction of the object A through image registration of the reference image and the second reference image.

Further, in the X-ray irradiation step (S10), after irradiating the ultra-short pulse in a first exposure period and reading detected X-ray data only for a predetermined region of interest (ROI), the code pulse is applied in the second exposure period. By minimizing the time difference (Δt in FIG. 4) between the first exposure period and the second exposure period by irradiation, deblurring of the code motion blur image may be effectively performed.

Further, in the method, apparatus, and system 100 for obtaining and processing an X-ray image using a hybrid pulse according to an embodiment of the present invention, the code pulse is at two levels of HIGH/LOW as shown in FIG. 11A. Although the case of configuring is described, the present invention is not necessarily limited thereto, and as shown in FIG. 11(b), the code pulse is configured at 3 levels or 4 levels or more of HIGH/MIDDLE/LOW. It is also possible to perform deblurring on the code motion blur image more effectively through this.

Accordingly, in the method, apparatus, and system 100 for obtaining and processing an X-ray image using a hybrid pulse according to an embodiment of the present invention, a motion that causes motion blur of an X-ray image is accurately identified and responded to it. By automatically obtaining a Motion Blur Point Spread Function, convenience of use is increased, and a high-precision motion point spread function (PSF) is calculated, as shown in FIGS. 12 and 13. , It is possible to effectively improve the quality of X-ray images such as high-quality and high-resolution image restoration.

More specifically, FIG. 12(a) illustrates an X-ray image generated while continuously irradiating X-rays from the X-ray source 110 (see FIG. 5(a1)). An X-ray image in the case of deblurring the image in (a) is illustrated.

On the other hand, in (a) of FIG. 13, an X-ray image generated by irradiating X-rays with an ultra-short pulse from the X-ray source 110 is illustrated, and in (b) of FIG. 13, X-rays are irradiated with code pulses from the X-ray source 110. The resulting X-ray image is illustrated, and FIG. 13 (c) illustrates an X-ray image when the image (b) of FIG. 13 is deblurred according to the present invention (function of the present invention). To illustrate, all images were generated through computer simulation).

As can be seen in FIGS. 12 and 13, it can be clearly confirmed that the image quality of the deblurred X-ray image (FIG. 13C) according to the present invention has been significantly improved.

In addition, FIG. 14 illustrates a specific flow chart of a method for generating an X-ray image according to an embodiment of the present invention.

As can be seen in FIG. 14, first, in step S100, the X-rays 110 are controlled to expose the X-rays to the object A in the form of an ultra-short pulse in the first exposure period.

Subsequently, in step S200, a reference image is generated by detecting X-rays of the ultrashort pulse.

Further, in step S300, the X-ray source 110 is controlled to expose X-rays to the object A in the form of a coded pulse having a preset pattern in a second exposure period.

Further, in step S400, an X-ray of the code pulse is detected to generate a code motion blur image.

In this case, as shown in FIG. 4, a hybrid dual frame image (USP_1 + CP_1) or a hybrid triple frame image (USP_1 + CP_1 + USP_2) may be obtained. .

In addition, in the method, apparatus, and system 100 for generating an X-ray image according to an embodiment of the present invention, the controller 120 does not modulate the exposure pattern by repeatedly turning on/off the X-ray source 110. It is also possible to drive in a way.

Furthermore, it is possible to minimize readout time by setting a detector region of interest (ROI).

Further, in step S500, a motion blur point spread function corresponding to the motion of the object A is calculated from the reference image and the code motion blur image.

More specifically, as a method of calculating the motion blur point spreading function (PSF), it is possible to calculate the motion blur direction and blur size from a dual or triple (2/3) frame, and calculate the motion blur point spreading function (PSF) through this. It is possible.

In addition, as another specific method, a machine learning regression technique can be applied, and through this, it is possible to calculate a motion blur point spreading function (PSF) from a dual or triple (2/3) frame.

In addition, in step S600, a combined point spreading function (PSF) is generated by combining the code point spreading function (PSF) extracted from the code motion blur image and the motion blur point spreading function (PSF), and the code motion blur image is An X-ray image is generated by deconvolution with a combined point spread function (PSF).

Accordingly, in the method, apparatus, and system 100 for generating an X-ray image using a hybrid pulse according to an embodiment of the present invention, a motion that causes motion blur of an X-ray image is accurately identified and motion blur corresponding thereto. By allowing automatic acquisition of the Motion Blur Point Spread Function, convenience of use can be increased and the quality of X-ray images can be effectively improved such as high-quality, high-resolution image restoration by calculating a high-precision motion point spread function (PSF). To be.

The above description is merely illustrative of the technical idea of the present invention, and those of ordinary skill in the art to which the present invention pertains will be able to make various modifications and variations without departing from the essential characteristics of the present invention. Therefore, the embodiments described in the present invention are not intended to limit the technical idea of the present invention, but to explain, and are not limited to these embodiments. The scope of protection of the present invention should be interpreted by the claims below, and all technical ideas within the scope equivalent thereto should be construed as being included in the scope of the present invention.

100: X-ray image generation system
110: X-ray source
120: control unit
130: X-ray detection unit
140: X-ray image generator

Claims (13)

In a method for generating an X-ray image of an object by an X-ray image generating system,
An X-ray irradiation step of sequentially irradiating X-rays of an ultra short pulse (USP) and a coded pulse (CP) having a shape of a predetermined code to the object by controlling the X-ray source (here, the first The pulse is irradiated for a shorter time than the code pulse);
A reference image generation step of generating a reference image by detecting X-rays of the ultrashort pulses that have passed through the object;
Generating a coded motion blur image by detecting X-rays of the code pulses passing through the object; And
And generating an X-ray image deblurred with respect to the code motion blur image by using the reference image and the code motion blur image. The method of claim 1,
In the step of generating the X-ray image,
Calculating a motion blur point spread function corresponding to a motion in the image of the object from the reference image and the code motion blur image; And
An X-ray image generating method comprising: generating an X-ray image deblurred with respect to the code motion blur image using the motion blur point spread function. . The method of claim 1,
In the X-ray irradiation step,
After irradiating the ultrashort pulse in the first exposure cycle,
The method of generating an X-ray image, comprising irradiating the code pulse in a second exposure period following the first exposure period. The method of claim 2,
The motion blur point spread function calculation step,
A blur direction calculation step of calculating a blur direction of the object using the reference image and the code motion blur image;
And calculating a blur size of the object using the reference image and the code motion blur image. The method of claim 4,
In the step of calculating the blur direction,
A method of generating an X-ray image, comprising calculating a blur direction of the object by using a fast Fourier transform (FFT) of the reference image and the code motion blur image. The method of claim 4,
In the step of calculating the blur size,
For a plurality of predetermined blur size candidate values, after calculating a plurality of candidate blur images using the reference image, comparing the similarity with the code motion blur image to calculate the blur size of the object. How to create an X-ray image. The method of claim 2,
In the motion blur point spreading function calculation step,
A method of generating an X-ray image, comprising calculating a motion blur point spreading function for the object from the reference image and the code motion blur image using a machine-learned first neural network circuit. The method of claim 2,
In the step of generating the X-ray image,
Calculating a code point spread function for the code pulse CP;
Calculating a combined point spread function in which the code point spread function and the motion blur point spread function are combined; And
And performing deblurring on the code motion blur image using the combined point spread function. The method of claim 3,
In the X-ray irradiation step,
After irradiating the code pulse in the second exposure period,
The method of generating an X-ray image, comprising further irradiating a second ultrashort pulse in a third exposure period following the second exposure period. The method of claim 9,
In the step of generating the X-ray image,
Calculate a virtual reference image at an arbitrary point in the second exposure period through interpolation of the reference image and the second reference image by the second ultrashort pulse,
And generating an X-ray image deblurred with respect to the blur image by using the virtual reference image. The method of claim 3,
In the X-ray irradiation step,
After irradiating the ultrashort pulse in a first exposure period and reading detected X-ray data only for a predetermined region of interest (ROI),
The method of generating an X-ray image, wherein a time interval between the first exposure period and the second exposure period is minimized by irradiating the code pulse in the second exposure period. The method of claim 1,
Generating an X-ray image, further comprising a test image step of calculating a code pulse CP corresponding to the motion of the object by estimating motion of the object from a preshot X-ray image of the object Way. In an X-ray image generation system for generating an X-ray image of an object,
An X-ray source that emits X-rays;
An X-ray detector configured to detect X-rays transmitted through the object;
A control unit that controls to sequentially irradiate X-rays of an ultra short pulse (USP) and a coded pulse (CP) having a shape of a predetermined code from the X-ray source to the object (here, the ultra short pulse) Is irradiated for a shorter time than the code pulse); And
An X-ray image deblurred with respect to the code motion blur image is obtained using a reference image generated from the X-ray of the ultrashort pulse and a coded motion blur image generated from the X-ray of the code pulse. An X-ray image generating system comprising: an X-ray image generating unit that generates.

Images