KR20210025033A - A composition having improved bioavailability of isoflavone - Google Patents

Abstract

The present invention relates to: a composition which can improve in vivo absorption rate, such as digestion absorption and skin permeation of isoflavone, which is a plant natural female hormone; a manufacturing method of the composition; and a packaging product comprising the composition. The composition has improved in vivo absorption rate of isoflavone, and comprises isoflavone, lecithin, a hydrophilic surfactant, and fats and oils.

Description

Composition having improved bioavailability of isoflavone {A composition having improved bioavailability of isoflavone}

The present specification relates to a composition containing a plant bioactive substance, particularly an isoflavone, capable of enhancing digestion and absorption of isoflavones and a bioabsorption rate such as skin permeation, a method of manufacturing the same, and a packaging article containing the composition. It is about.

Due to the increase in the elderly population, osteoporosis patients are also increasing rapidly. Osteoporosis patients are overwhelmingly more female than males, and 25-30% of elderly women have severe symptoms such as fractures. This osteoporosis occurs mainly in postmenopausal women and is caused by a rapid decrease in the female hormone estrogen. At first, there is not much bone loss and no symptoms at all, and then it suddenly leads to a fracture, so it is known as a very difficult disease to prevent.

Estrogen binds to the nucleophilic receptors estrogen receptor alpha (ERa) and estrogen receptor beta (ERb), and these receptors are expressed in most living tissues including bone. In other words, it is known that bone binds to estrogen receptors to participate in bone remodeling, activates the proliferation of osteoblasts, and creates a fine atmosphere that kills osteoclasts.

However, in menopause, the secretion of estrogen rapidly decreases, resulting in a decrease in bone formation ability, resulting in loss of calcium and deoxypyridinoline (DPD; collagen crosslinking agent) in bone tissue, resulting in a decrease in Bone Mineral Density (BMD, bone density). Accordingly, in order to prevent osteoporosis, the Women's Health Initiative (WHI) conducted a clinical trial on hormone therapy (HRT) using estrogen in postmenopausal women, but it was conducted for 5 years due to serious side effects that increase the incidence of breast cancer, uterine cancer, and melanoma. Then stopped.

Accordingly, selective estrogen receptor modulators (SERMs) such as raloxifene have been developed and used to replace estrogen, but there is a tendency to avoid using it due to side effects such as cardiovascular disease and flushing.

Therefore, isoflavone as an estrogen substitute is widely used as a health functional food that prevents diseases or symptoms caused by lowering of female hormones.

Soybean is the main ingredient for isoflavones, and the isoflavones in soybeans are composed of daidzin and genistin.

When soybeans are ingested, daidzin and genistin are not absorbed as they are, and the glucose part is converted into daidzein (DZ) and genistein (GN), which are hydrolyzed by intestinal microbes in the large intestine, and then absorbed into the body by passive diffusion. However, much of the absorbed DZ and GN is inactivated due to glucuronization and/or sulfation in the 1st-pass metabolic stage of intestinal cells or liver, as in the following example:

Isoflavones (DZ, GN, etc.) absorbed in the body are similar to estrogen in chemical structure, so their activity is relatively low, but they play the role of female hormones. In other words, isoflavones play a role in binding and expressing estrogen receptors, but the activities of DZ and GN are not relatively high at 1 and 7% compared to estrogen.

Many clinical studies have been conducted so far on the effect of isoflavones on BMD as an estrogen substitute. As a result, it is reported that the results are generally effective for BMD in Japan, China, and Hong Kong, while in the West, such as the United States and the Netherlands, they are either ineffective or weak.

Due to these results, it is necessary to develop an isoflavone formulation having excellent absorbency that can exhibit more universal and excellent effects regardless of East and West.

Korean Patent Registration No. 10-1195114 Korean Patent Registration No. 10-1815316 European patent EP 1833498 B1

Korean J. Medicinal Crop Sci., 21, 401-414, 2013 Food safety commission, novel foods expert committee, Japan, 2006 CrystEngComm, 19, 7146-7153, 2017 Biosci. Biotechnol. Biochem., 71(12), 2927-2933, 2007 Comprehensive evaluation of the role of soy and isoflavone supplementation in humans and animals over the past two decades. Wiley. 2018 The Journal of Clinical Endocrinology & Metabolism. 2001;86(11):5217-5221 Am J Clin Nutr. 2009;90:234-42 J Korean Med Sci. 2009;24:867-73 Acta Pharmacologica Sinica. 2005; 26(9): 1145-1152 Nature Rev. Drug Disc. 2007; 6: 231-248 Biomed. Pharmacother. 2004; 58: 173-182

Accordingly, the present inventors have studied a composition containing a plant-derived physiologically active substance, particularly isoflavone, which is a plant-derived physiologically active substance that facilitates the absorption of isoflavones through the digestive system and skin.

Drugs that are difficult to absorb in the body because they are not soluble in water are called poorly soluble drugs. Usually, they refer to drugs that have a water solubility of 100 mg/L or less or that are incompletely dissolved in 250 ml of water. The isoflavones, DZ and GN, have a solubility in water of about 2 mg/L and about 1 mg/L, respectively, and are extremely poorly soluble in water. According to animal experiments using rats, it is reported that only 6.1% of DZ is absorbed in the body, which is estimated to be the main cause of low water solubility. Therefore, the present invention is to provide a novel composition formulation capable of improving the absorption and bioavailability of isoflavones in the body.

The object of the present invention is not limited to the object mentioned above. Objects of the present invention will become more apparent from the following description, and will be realized by means described in the claims and combinations thereof.

One aspect of the present invention is a vegetable physiologically active substance; And fats and oils; wherein the plant physiologically active substance is fat-soluble, and the plant physiologically active substance is a hydrolyzed plant physiologically active substance or a non-glycosylated plant physiologically active substance, wherein the bioabsorption rate of isoflavone is improved. The composition is provided.

In one aspect of the present invention, the plant physiologically active substance is saponin, ginsenoside, polyphenol, isoflavone, quercetin, campperitrin, anthocyanin, beta-carotene, isoflavone comprising any one or more of quocumin and lycopene It provides a composition with improved bioabsorption rate.

In one aspect of the present invention, the non-glycosylated plant physiologically active substance provides a composition with improved bioabsorption of isoflavones, including any one or more of saponin non-glycoside, isoflavone non-glycoside, and polyphenol non-glycoside. .

In one aspect of the present invention, the fat or oil is lecithin, oleic acid, fish-derived omega-3, fish oil, flaxseed oil, hemp seed oil, perilla oil, sesame oil, evening primrose oil, linoleic acid, butter, soybean oil, grape seed oil, palm oil, olive oil. , Almond oil, malt oil, castor oil, avocado oil, moonshine colostrum, rosehill oil, shark liver oil, and milk oil.

In one aspect of the present invention, the composition provides a health functional food composition or a cosmetic composition, a composition in which the bioabsorption rate of isoflavone is improved.

Another aspect of the present invention is a method for preparing a composition having an improved bioabsorption rate of isoflavone according to any one of the above,

(a) providing a plant raw material;

(b) extracting a plant physiologically active substance from the provided plant raw material using a fat-soluble organic solvent; And

(c) mixing the extracted botanical physiologically active substances with fats and oils; wherein the fats and oils include lecithin, oleic acid, fish-derived omega-3, fish oil, flaxseed oil, hemp seed oil, perilla oil, sesame oil, and decoction oil , Linoleic acid, butter, soybean oil, grapeseed oil, palm oil, olive oil, almond oil, malt oil, castor oil, avocado oil, moonshine colostrum, rosehill oil, shark liver oil, and milk oil. It provides a method of preparing the enhanced composition.

In another aspect of the present invention, in the step (a), the plant raw material is berries, ginseng, bellflower, beans, hops, aronia, capers, onions, turmeric, tomatoes, carrots, kale, spinach, green tea, and Contains one or more of the pine needles,

The step (a) provides a method for preparing a composition with improved bioabsorption of isoflavones, including powdering a plant material.

In another aspect of the present invention, the manufacturing method further comprises a step of hydrolyzing the provided plant raw material between steps (a) and (b), wherein the hydrolysis is biological hydrolysis, chemical hydrolysis, and It provides a method for preparing a composition having an improved bioabsorption rate of isoflavone, which is at least one of the pyrolysis methods.

In another aspect of the present invention, the biological hydrolysis is a microbial, enzyme, or hydrolysis using microorganisms and enzymes, and the chemical hydrolysis is hydrolysis using an acid or alkali, a composition with improved bioabsorption of isoflavones It provides a method of manufacturing.

Another aspect of the present invention is a method for preparing a composition having an improved bioabsorption rate of isoflavone according to any one of the above,

(a) providing a plant physiologically active substance in the form of a non-glycoside; And

(b) mixing the non-glycosylated vegetable physiologically active substance with fats and oils; and the fats and oils include lecithin, oleic acid, fish-derived omega-3, fish oil, flaxseed oil, hemp seed oil, perilla oil, sesame oil , Evening primrose oil, linoleic acid, butter, soybean oil, grapeseed oil, palm oil, olive oil, almond oil, malt oil, castor oil, avocado oil, moonshine colostrum, rosehill oil, shark liver oil, and milk oil. It provides a method for preparing a composition with improved bioabsorption rate.

In another aspect of the present invention, the non-glycoside form of the plant physiologically active material comprises any one or more of saponin non-glycoside, isoflavone non-glycoside, and polyphenol non-glycoside, wherein the bioabsorption rate of isoflavone is improved. Provides a manufacturing method.

Another aspect of the present invention is a packaging article containing a composition having an improved bioabsorption rate of isoflavones, wherein the packaging article comprises: a first unit containing the vegetable physiologically active material; And a second unit including oil and fat, wherein the first unit and the second unit are separated by a grip, but when the grip is removed, the vegetable physiologically active material included in the first unit and the second unit are included. It provides a packaging article containing a composition in which fats and oils are mixed, the bioabsorption rate of isoflavones is enhanced.

In yet another aspect of the present invention, the vegetable physiologically active substance contained in the first unit is in the form of a dried powder, and the fat or oil contained in the second unit is the fat or oil contained in the solubilized aqueous solution, the bioabsorption rate of the isoflavone It provides a packaging article containing the enhanced composition.

Another aspect of the present invention provides a health functional food that facilitates ingestion in the form of a gel such as soft yokan or jelly in a packaging article containing a composition having an improved bioabsorption rate of isoflavone. A fat-soluble/vegetable physiologically active substance-containing oil component is dispersed in 5-15 wt% of gelatin or agar aqueous solution, and then gelled at low temperature to provide a gel-type physiologically active substance carrier. At this time, the stability of the emulsion may be improved by basifying the pH by incorporating a small amount of cationic amino acids such as histidine, lysine, and arginine.

Another aspect of the present invention, isoflavone; lecithin; Hydrophilic surfactants; It provides a composition with improved bioabsorption rate of isoflavones comprising; and fats and oils.

In yet another aspect of the present invention, the isoflavone provides a composition with improved bioabsorption rate of isoflavone, comprising any one or more of daidzein, genistein, and equal. .

In yet another aspect of the present invention, the lecithin provides a composition comprising at least one of soy-derived lecithin and egg-derived lecithin, with improved bioabsorption of isoflavones.

In another aspect of the present invention, the hydrophilic surfactant is saponin, Tween 20, Tween 40, Tween 60, Tween 80, and sucrose. It provides a composition comprising at least one of sucorose monolaurate and polyoxyethylene sorbitan monostearate, wherein the bioabsorption rate of isoflavone is improved.

In another aspect of the present invention, the fat or oil is oleic acid, fish-derived omega-3, fish oil, flaxseed oil, hemp seed oil, perilla oil, sesame oil, evening primrose oil, linoleic acid, butter, soybean oil, grapeseed oil, palm oil, It provides a composition comprising at least one of olive oil, almond oil, malt oil, castor oil, avocado oil, moonshine colostrum, rosehill oil, and shark liver oil, with improved bioabsorption of isoflavones.

In another aspect of the present invention, the isoflavone, lecithin, hydrophilic surfactant, and fat are contained in a weight ratio of 1: 6 to 10: 0.05 to 0.15: 0.5 to 5, wherein the bioabsorption rate of isoflavone is improved. Provides.

In another aspect of the present invention, based on 100 parts by weight of the isoflavone, lecithin is 600 to 1000 parts by weight, hydrophilic surfactant is 5 to 15 parts by weight, fats and oils are contained in 50 to 500 parts by weight, It provides a composition with improved bioabsorption rate.

In another aspect of the present invention, the isoflavone, lecithin, hydrophilic surfactant, and fat are included in a weight ratio of 1: 6 to 10: 0.05 to 0.15: 0.5 to 5, and the isoflavone is daidzein or genistein. And, the lecithin is soybean-derived lecithin or egg-derived lecithin, the hydrophilic surfactant is saponin, the fats and oils are oleic acid, and the bioabsorption rate of isoflavones is improved.

In another aspect of the present invention, the composition provides a health functional food composition or a cosmetic composition, a composition in which the bioabsorption rate of isoflavone is improved.

In another aspect of the present invention, the composition is a health functional food composition, and the food is any one or more of nutrients, chocolate, soy milk, milk, and gelled foods, providing a composition with improved bioabsorption of isoflavones. .

When the composition according to an embodiment of the present invention is used as a health functional food, the bioabsorption rate can be increased, and active ingredients of animals and plants can be absorbed at the same time in a single dose, providing convenience in taking, and providing a wider and more effective physiological health. Function can be given.

When the composition according to an embodiment of the present invention is introduced into cosmetics, functional cosmetic effects such as antioxidant, anti-aging, and wrinkle improvement can be expected.

The composition according to an embodiment of the present invention can significantly increase the bioabsorption rate of isoflavones compared to existing isoflavone formulations.

The effects of the present invention are not limited to the above-mentioned effects. It should be understood that the effects of the present invention include all effects that can be inferred from the following description.

1 is an isoflavone concentration and absolute viscosity of an isoflavone paste according to Experimental Example 4. FIG.
2 is a pharmacological experiment result of a bioisoflavone paste (Example 1) and a bioisoflavone powder (comparative group) according to Experimental Example 5.

Unless otherwise specified, all numbers, values, and/or expressions expressing ingredients, reaction conditions, and content of ingredients used herein are the various types of measurements that occur in obtaining these values, among other things in which these numbers are essentially different. Since they are approximations that reflect uncertainty, it should be understood as being modified in all cases by the term "about". In addition, when numerical ranges are disclosed herein, such ranges are continuous and, unless otherwise indicated, include all values from the minimum value of this range to the maximum value including the maximum value. Furthermore, where this range refers to an integer, all integers from the minimum to the maximum value including the maximum value are included, unless otherwise indicated.

In the present specification, where a range is described for a variable, it will be understood that the variable includes all values within the stated range, including the stated endpoints of the range. For example, a range of “5 to 10” includes values of 5, 6, 7, 8, 9, and 10, as well as any subranges such as 6 to 10, 7 to 10, 6 to 9, 7 to 9, etc. Inclusive, and it will be understood to include any values between integers that are reasonable in the scope of the stated range, such as 5.5, 6.5, 7.5, 5.5 to 8.5 and 6.5 to 9, and the like. Also, for example, the range of "10% to 30%" is 10% to 15%, 12% to 10%, 11%, 12%, 13%, etc., as well as all integers including up to 30%. It will be understood to include any subranges, such as 18%, 20% to 30%, and the like, and include any values between reasonable integers within the scope of the stated range, such as 10.5%, 15.5%, 25.5%, and the like.

Hereinafter, the present invention will be described in detail.

In the pharmaceutical field, since 50-60% of drugs are poorly soluble drugs that are not well soluble in water, the solubilization technology of various poorly soluble drugs such as fine powdering, solid dispersion, cyclodextrin (CD) inclusion, nano suspension, and fat transporter has been developed. have.

Among these solubilization technologies, a technology for solubilizing isoflavones using CD inclusion has been developed (Korean Patent 10-1195114). This method can cause sedimentation due to dissociation of CD inclusion in the digestive tract, and inactivation of many parts of the 1st-pass metabolism can lead to loss of efficacy. In addition, the CD clathrate of the isoflavone glycoside is not highly effective as an estrogen.

There are various methods such as liposomes, emulsions, suspensions, fatty nanoparticles, and self-emulsifying delivery systems for fat delivery systems. As a fat transporter of isoflavones, niosomes, which are fat nanoparticles in a solid state, have been developed for cosmetics (Korea/10-1815316). This does not improve absorption in the digestive system because biocompatible solvents are used in the manufacturing process and lipids that are non-solvent for isoflavones are used, so that isoflavones exist in a solid state. In EP 1 833498 B1, an emulsion containing isoflavones was prepared using omega 3 and a small amount of phospholipids as surfactants. At this time, omega 3 has a disadvantage that it is not effective as an oral fat delivery system because it has a severe odor and does not have a high solubility in isoflavones.

Fat is emulsified by bile salts and lipolytic enzymes in the small intestine and is digested and absorbed. Oral fat transporters utilize this property. In other words, if a drug is dissolved in fat, it is mixed with fat particles emulsified in the small intestine and absorbed, or the drug is dissolved in water and absorbed in the small intestine. This oral fat delivery system 1) improves solubility; 2) prevention of sedimentation in the digestive tract; 3) improved membrane permeability; 4) inhibition of efflux; 5) Reduction of CYPs enzymes involved in 1st-pass metabolism; 6) It acts to actively improve the absorption of drugs in the body by acting such as lymphatic absorption. The above-described functions of the fat transporter can serve to more actively digest and absorb isoflavones, so they have been grafted onto isoflavones.

For this purpose, isoflavones must be dissolved in fat, so lecithin, vitamin E, oleic acid, fish-derived omega-3, fish oil, flaxseed oil, hemp seed oil, perilla oil, sesame oil, evening primrose oil, linoleic acid, soybean oil, grapeseed oil, palm oil, olive oil , Almond oil, malt oil, castor oil, avocado oil, walnut colostrum oil, rosehill oil, shark liver oil, etc., as a result of dissolving isoflavones, isoflavones are known as fat-soluble substances, but they are not well soluble in most fats. In other words, isoflavones are relatively hydrophobic because they have a hydrophilic hydroxyl group, and they do not dissolve well in fats with a hydrophilic-lipophilic balance (HLB) close to zero, and are relatively best dissolved in lecithin, a phospholipid. It is thought that the HLB of lecithin is about 4-8, which is relatively hydrophilic, so isoflavones with hydrophilic functional groups are relatively more soluble.

However, since lecithin alone does not emulsify well in water, dispersing and emulsifying within the digestive tract may not be smooth when taken. Therefore, it is preferable to use a more hydrophilic edible surfactant.

In addition, lecithin can be used alone, but its viscosity (Brookfield viscosity = 8,000-10,000 cP) is very high, so it is difficult to make a mixed formulation with a powder, so it is more preferable to combine it with other fats and oils having a low viscosity. There are various types of oils and fats, so they can be selected and used to enhance functionality.

Accordingly, the inventors of the present invention have completed the present invention by studying a fat transporter that facilitates the absorption of isoflavones through the digestive system.

Fat is emulsified into micelles, which are small particles by bile salts and lipolytic enzymes, in the small intestine, and then absorbed into the body through enterocytes. The lipid carrier used for drug delivery uses the above-described mechanism of digestion and absorption of fat.If the drug is dissolved in fat, the drug is also microparticles by emulsifying the fat in the small intestine and digested as it is in the micelles. After being absorbed or diffused into water, it is absorbed into the body through the window cell membrane.

As a result of solubility tests for various fats to prepare the fat transporter of isoflavones, it was found that HLB is relatively soluble in 4-8 lecithin. There are glycerol monostearate, sorbitan monooleate, sorbitan monostearate, and sorbitan monopalmitate among synthetic surfactants for foods with HLB values in this range, but these synthetic products have a problem that toxic substances may be mixed in the organic synthesis process.

On the other hand, since lecithin is extracted from eggs or beans, it is relatively safe because it hardly comes into contact with toxic substances. In addition, since lecithin has a function of lowering cholesterol or triglycerides, it has a synergistic effect in terms of health function. For isoflavone dissolution, the composition ratio of lecithin is preferably 60-90%.

Only lecithin may be used as a fatty solvent for isoflavones, but in order to facilitate emulsification in the digestive tract, a food-grade hydrophilic surfactant having a higher HLB than lecithin may be added and used. Self-emulsifying fat carriers are called self-emulsifying carriers, and hydrophilic surfactants that can be used include saponin, Tween series, fructose surfactants (such as sucorose monolaurate), and polyoxyethylene sorbitan monostearate. Since saponin is plant-derived, it has almost no toxicity and has excellent mixing properties with lecithin, so it is preferable.

The hydrophilic surfactant is preferably a surfactant having an HLB of 10 or more, and the composition ratio is suitably 0-10%, more preferably 0-8%, and still more preferably 0-5%.

Lecithin can also be used alone, but its viscosity is very high, so it is difficult to make a powdery and mixed formulation, so it is more preferable to combine it with other fats and oils having a low viscosity. There are various types of oils and fats, so they can be selected and used to enhance functionality.

Oils and fats include oleic acid, fish-derived omega-3, fish oil, flaxseed oil, hemp seed oil, perilla oil, sesame oil, decoction oil, linoleic acid, soybean oil, grape seed oil, palm oil, olive oil, almond oil, malt oil, castor oil, avocado oil. , Moongyeon colostrum oil, rosehill oil, shark liver oil, etc. can be used.

The addition of fats and oils acts to lower the solubility of isoflavones in the isoflavone/lecithin complex, so the amount of the oil and fat is preferably 40% or less of the total composition.

As a health functional food, the raw material of isoflavones is generally produced by fermenting soybeans such as soybeans with microorganisms and drying the fermented product. Therefore, in the raw material, not only DZ and GN, which are non-glycosides, are present, but as a mixture with proteins and tin hydrates, DZ and GN are generally present at a concentration of 100-300 mg/g.

The recommended daily intake of isoflavone by the Korean Food and Drug Administration is 24-27 mg/d, so the combined amount of lecithin, surfactant, and fat should be determined in consideration of the recommended daily intake of isoflavone. In addition, since the recommended daily intake of essential fatty acids is limited to 2-4 g, the concentration of oil and fat and isoflavones should be determined in consideration of this.

In isoflavones, there is also equol in which DZ is produced by microbial fermentation, and equol-rich soybean fermented powder containing this can also be used as a raw material for isoflavones of this patent. Microorganisms that can produce equol include Adlercreutzia equolifaciens, Bifidobacterium, and Veillonella sp. The amount of equol in the lecithin carrier including the equol-rich fermented soybean powder is suitably set at a concentration of 5-30 mg/g.

In addition to the above fermented powder, isoflavones such as isoflavones such as equol, DZ, GN, etc. are separated and purified from fermented products, or highly concentrated isoflavones such as organically synthesized compounds can be used in the present invention. Even in this case, the daily intake of total isoflavones follows the recommended amount of each country's Ministry of Food and Drug Safety.

The composition containing the isoflavone is mixed using a mixing device capable of mixing and pulverizing fine particles such as a colloid mill, a homomixer, and a bead mill.

Since the isoflavone lecithin carrier of the present invention is in the form of a paste, it is convenient to use it as a health functional food by formulating it into a soft capsule composed of gelatin, carrageenan, starch, and the like. Since the manufacturing method of the soft capsule is a known technique, no further description is made in the present invention.

Since the isoflavone lecithin delivery system of the present invention can be easily emulsified in water, it can be used in combination with soy milk or milk. Soy milk or milk contains various nutrients as well as calcium and vitamin D, which are good for bone health. It is thought that if isoflavone is fortified, it can be a better health food.

In East Asia including Korea, ginseng or red ginseng is widely used as a health functional food for strengthening immune function. These ginseng products contain a large amount of saponin, which acts as a surfactant, so that the isoflavone/lecithin complex of the present invention is more smoothly emulsified. Therefore, when the isoflavone/lecithin complex is incorporated into ginseng products, the function of isoflavones and the immune enhancing function are strengthened, so that a wider and superior health functional food can be manufactured.

This isoflavone/lecithin complex has the ability to mix well with chocolate. In addition, since it has the property of being easily emulsified in water, it can be mixed with gelatin or agar to prepare a health functional food.

Hereinafter, various aspects of the present invention will be described.

One aspect of the present invention is a vegetable physiologically active substance; And fats and oils; wherein the plant physiologically active substance is fat-soluble, and the plant physiologically active substance is a hydrolyzed plant physiologically active substance or a non-glycosylated plant physiologically active substance, wherein the bioabsorption rate of isoflavone is improved. Provide composition.

In one embodiment, the plant material and oil including the vegetable physiologically active material may be included in a weight ratio of 1: 1 to 10. Preferably, it may be included in a weight ratio of 1: 2 to 8, a weight ratio of 1: 3 to 7, or a weight ratio of 1: 4 to 6. More preferably, it may be included in a weight ratio of 1:5.

In one aspect of the present invention, the botanical physiologically active substance is saponin, ginsenoside, polyphenol, isoflavone, quercetin, campperitrin, anthocyanin, beta-carotene, isoflavone comprising any one or more of quocumin and lycopene It provides a composition with improved bioabsorption rate.

In one embodiment, the plant raw materials are berries such as aronia for anthocyanin, ginseng, bellflower, beans, etc. for saponin and ginsenosides, legumes and hops such as red beans for isoflavones, capers for quercetin, You can use onions, such as turmeric for quocumin, tomatoes for lycopene, carrots for beta-carotene, and green tea for polyphenols.

In one aspect of the present invention, the non-glycosylated plant physiologically active substance provides a composition with improved bioabsorption of isoflavones, including any one or more of saponin non-glycoside, isoflavone non-glycoside, and polyphenol non-glycoside. .

In one aspect of the present invention, the fat or oil is lecithin, oleic acid, fish-derived omega-3, fish oil, flaxseed oil, hemp seed oil, perilla oil, sesame oil, evening primrose oil, linoleic acid, butter, soybean oil, grape seed oil, palm oil, olive oil. , Almond oil, malt oil, castor oil, avocado oil, moonshine colostrum, rosehill oil, shark liver oil, and milk oil.

In one aspect of the present invention, the composition provides a health functional food composition or a cosmetic composition, a composition in which the bioabsorption rate of isoflavone is improved.

Another aspect of the present invention is a method for preparing a composition having an improved bioabsorption rate of isoflavone according to any one of the above,

(a) providing a plant raw material;

(b) extracting a plant physiologically active substance from the provided plant raw material using a fat-soluble organic solvent; And

(c) mixing the extracted botanical physiologically active substances with fats and oils; wherein the fats and oils include lecithin, oleic acid, fish-derived omega-3, fish oil, flaxseed oil, hemp seed oil, perilla oil, sesame oil, and decoction oil , Linoleic acid, butter, soybean oil, grapeseed oil, palm oil, olive oil, almond oil, malt oil, castor oil, avocado oil, moonshine colostrum, rosehill oil, shark liver oil, and milk oil. It provides a method of preparing the enhanced composition.

In another aspect of the present invention, in the step (a), the plant raw material is berries, ginseng, bellflower, beans, hops, aronia, capers, onions, turmeric, tomatoes, carrots, kale, spinach, green tea, and Contains one or more of the pine needles,

The step (a) provides a method for preparing a composition with improved bioabsorption of isoflavones, including powdering a plant material.

In one embodiment, the providing of the plant raw material may include washing the plant raw material, drying or freeze-drying the plant raw material, and pulverizing and powdering the plant raw material. In the step of washing plant raw materials, impurities such as residual pesticides can be removed. If necessary, pesticide residues can be tested. Powdering can play a role in improving the efficiency of the next step, hydrolysis.

In another aspect of the present invention, the manufacturing method further comprises a step of hydrolyzing the provided plant raw material between steps (a) and (b), wherein the hydrolysis is biological hydrolysis, chemical hydrolysis, and It provides a method for preparing a composition having an improved bioabsorption rate of isoflavone, which is at least one of the pyrolysis methods.

In another aspect of the present invention, the biological hydrolysis is a microbial, enzyme, or hydrolysis using microorganisms and enzymes, and the chemical hydrolysis is hydrolysis using an acid or alkali, a composition with improved bioabsorption of isoflavones It provides a method of manufacturing.

In one embodiment, the hydrolysis may be a chemical method using microorganisms, enzymes, acids or alkalis, or a pyrolysis method at high temperature and high pressure. The method should be determined according to the type of plant material and the use of the extracted physiologically active substance. That is, if a specific substance is required, it is preferable to hydrolyze with an enzyme, otherwise, chemical hydrolysis and pyrolysis may be economical.

In one embodiment, all microorganisms capable of decomposing carbohydrates, especially cellulose, such as Bacillus bacteria, lactic acid bacteria, Aspergillus bacteria, and Lactobacillus bacteria, are all possible and appropriate culture conditions may be followed. When using the enzyme digestion method, glycosylases such as glucoamylase, amylase, glucosidase, cellulase, or complex enzymes thereof may be used. Proteolytic enzymes such as protease are complexly used in plant materials with a lot of protein, such as soybeans. Temperature, pH, etc., which indicate the maximum resolution of enzymes, differ depending on the type, so you can search for optimal conditions by referring to the vendor's advice.

In one embodiment, the chemical hydrolysis method using an acid or alkali has an economic advantage, but does not selectively decompose. Strong acids and strong bases are used as catalysts and neutralized after hydrolysis. Pyrolysis at more than 100 ^o C can also be used, but benzopyrene should not be formed.

In one embodiment, the material after the hydrolysis step is sufficiently dried, mixed with oil and fat, and subjected to an extraction step for a certain period of time to extract a fat-soluble physiologically active substance to prepare a fat-soluble physiologically active substance-containing oil or fat composition. Alternatively, after extracting a fat-soluble physiologically active substance using a fat-soluble organic solvent such as nucleic acid, the organic solvent is removed to obtain a pure fat-soluble physiologically active substance, and then mixed with fat to prepare a fat-soluble physiologically active substance-containing fat composition. .

In one embodiment, the fat or oil used is irrelevant of origin, such as animals and plants, minerals, etc., as long as there is no toxicity. In other words, lecithin, oleic acid, fish-derived omega-3, fish oil, flaxseed oil, hemp seed oil, perilla oil, sesame oil, decoction oil, linoleic acid, etc. can be used in the manufacture of health functional foods. , Grapeseed oil, etc. may be used, and for cosmetics, palm oil, olive oil, almond oil, malt oil, castor oil, avocado oil, walnut colostrum oil, rose heel oil, shark liver oil, and milk oil may be used.

Another aspect of the present invention is a method for preparing a composition having an improved bioabsorption rate of isoflavone according to any one of the above,

(a) providing a plant physiologically active substance in the form of a non-glycoside; And

(b) mixing the non-glycosylated vegetable physiologically active substance with fats and oils; and the fats and oils include lecithin, oleic acid, fish-derived omega-3, fish oil, flaxseed oil, hemp seed oil, perilla oil, sesame oil , Evening primrose oil, linoleic acid, butter, soybean oil, grapeseed oil, palm oil, olive oil, almond oil, malt oil, castor oil, avocado oil, moonshine colostrum, rosehill oil, shark liver oil, and milk oil. It provides a method for preparing a composition with improved bioabsorption rate.

In another aspect of the present invention, the non-glycoside form of the plant physiologically active material comprises any one or more of saponin non-glycoside, isoflavone non-glycoside, and polyphenol non-glycoside, wherein the bioabsorption rate of isoflavone is improved. Provides a manufacturing method.

Another aspect of the present invention is a packaging article containing a composition having an improved bioabsorption rate of isoflavones, wherein the packaging article comprises: a first unit containing the vegetable physiologically active material; And a second unit including oil and fat, wherein the first unit and the second unit are separated by a grip, but when the grip is removed, the vegetable physiologically active material included in the first unit and the second unit are included. It provides a packaging article containing a composition in which fats and oils are mixed, and the bioabsorption rate of isoflavone is enhanced.

In yet another aspect of the present invention, the vegetable physiologically active material contained in the first unit is in the form of a dried powder, and the fat or oil contained in the second unit is the fat or oil contained in the solubilized aqueous solution, wherein the bioabsorption rate of isoflavone is It provides a packaging article containing the enhanced composition.

Functional food materials are substances that can quickly deteriorate in water or oil, and a method that can extend their preservation period is very useful for improving economic efficiency. Also, many people do not prefer omega-3 and 6, fish oil, and flaxseed oil because they do not taste or smell good. In order to solve such a problem, a functional food material is stored in a dried state as shown in FIG. 2, and a solubilizing aqueous solution capable of solubilizing or dispersing fats and oils and food materials is packaged on the other side. This solubilized aqueous solution contains edible oils and fats, edible surfactants, water-soluble natural polymer substances, amino acids, water, and the like. The powder and aqueous solution are separated by a grip, and if this grip is removed and rubbed before ingestion, a packaging technology that can be solubilized or mixed with each other can be provided.

Another aspect of the present invention is a method for preparing a composition with improved bioabsorption of isoflavones in a gel form, in which a fat or oil composition containing the vegetable physiologically active substance is added to an aqueous solution containing a basic amino acid and a gel-forming substance. It provides a method for preparing a composition with improved bioabsorption of isoflavones in a gel form, comprising the step of dispersing.

In yet another aspect of the present invention, the gel-generating material comprises any one or more of gelatin, agar, and alginate, a method for preparing a composition with improved bioabsorption of isoflavones in gel form Provides.

In yet another aspect of the present invention, there is provided a method for preparing a composition with improved bioabsorption of isoflavones in gel form, including any one or more of histidine, lysine, and arginine as the basic amino acid.

Another aspect of the present invention provides a physiologically active material delivery system that facilitates ingestion in the form of a gel, such as yam or jelly, in a packaging article containing a composition having an improved bioabsorption rate of isoflavone. That is, a fat-soluble/vegetable physiologically active substance-containing oil component is dispersed in 5-15 wt% of gelatin or agar aqueous solution or a mixture thereof and emulsified, and then gelled at low temperature to provide a gel-type physiologically active substance carrier. At this time, the stability of the emulsion may be improved by basifying the pH by incorporation of cationic amino acids such as arginine, histidine, and lysine. Such a gel-type carrier is easy to introduce a taste that suits the consumer's preference, and thus has the advantage of improving health functions while ingesting it like a general confectionery food.

If 0.5-2 wt% of lecithin is sufficient, the apparent stability of the emulsion is sufficiently indicated, so the amount of the cationic amino acid to be incorporated can be appropriately adjusted as necessary.

Another aspect of the present invention, isoflavone; lecithin; Hydrophilic surfactants; It provides a composition with improved bioabsorption rate of isoflavones comprising; and fats and oils.

In yet another aspect of the present invention, the isoflavone provides a composition with improved bioabsorption rate of isoflavone, comprising any one or more of daidzein, genistein, and equal. .

In yet another aspect of the present invention, the lecithin provides a composition comprising at least one of soy-derived lecithin and egg-derived lecithin, with improved bioabsorption of isoflavones.

In another aspect of the present invention, the hydrophilic surfactant is saponin, Tween 20, Tween 40, Tween 60, Tween 80, and sucrose. It provides a composition comprising at least one of sucorose monolaurate and polyoxyethylene sorbitan monostearate, wherein the bioabsorption rate of isoflavone is improved.

In another aspect of the present invention, the fat or oil is oleic acid, fish-derived omega-3, fish oil, flaxseed oil, hemp seed oil, perilla oil, sesame oil, evening primrose oil, linoleic acid, butter, soybean oil, grapeseed oil, palm oil, It provides a composition comprising at least one of olive oil, almond oil, malt oil, castor oil, avocado oil, moonshine colostrum, rosehill oil, and shark liver oil, with improved bioabsorption of isoflavones.

In another aspect of the present invention, the isoflavone, lecithin, hydrophilic surfactant, and fat are contained in a weight ratio of 1: 6 to 10: 0.05 to 0.15: 0.5 to 5, a composition with improved bioabsorption of isoflavones Provides.

In another aspect of the present invention, with respect to 100 parts by weight of the isoflavone, lecithin is 600 to 1000 parts by weight, hydrophilic surfactant is 5 to 15 parts by weight, and fat is 50 to 500 parts by weight of isoflavones. It provides a composition with improved bioabsorption rate.

In another aspect of the present invention, the isoflavone, lecithin, hydrophilic surfactant, and fat are included in a weight ratio of 1: 6 to 10: 0.05 to 0.15: 0.5 to 5, and the isoflavone is daidzein or genistein. And, the lecithin is soybean-derived lecithin or egg-derived lecithin, the hydrophilic surfactant is saponin, the fat or oil is oleic acid, and the bioabsorption rate of isoflavone is improved.

In another aspect of the present invention, the composition provides a health functional food composition or a cosmetic composition, a composition in which the bioabsorption rate of isoflavone is improved.

In another aspect of the present invention, the composition is a health functional food composition, and the food is any one or more of nutrients, chocolate, soy milk, milk, and gelled foods, providing a composition with improved bioabsorption of isoflavones. .

Hereinafter, the present invention will be described in more detail through specific examples. The following examples are only examples to aid understanding of the present invention, and the scope of the present invention is not limited thereto.

Example 1

Bioisoflavone (contains 187.5 mg/g or more of soy isoflavone, made by SK Bioland), which is used as an isoflavone, as a raw material for health functional food, contains 800 g of soy lecithin (ADM) and egg lecithin (egg lecithin) in 100 g of powder. , Kewpie (manufactured by Kewpie) 50 g, slowly mixed with a food mixer, oleic acid 100 g and saponin (Junsei) 10 g, thoroughly mixed, and then mixed and pulverized using a colloid mill to complete the isoflavone paste. This isoflavone paste is placed in ^{a vacuum defoaming machine at 80 o} C and allowed to stand for 24 hours, and then air bubbles are removed and a soft capsule is manufactured with a laboratory soft capsule maker.

Example 2

Isoflavones In 100 g of bioisoflavone (manufactured by SK Bioland) powder, which is used as a raw material for health functional foods, 800 g of soy lecithin (manufactured by ADM) and 50 g of egg lecithin (manufactured by Kewpie) were slowly mixed with a food mixer and oleic acid 200 g and 10 g of saponin (manufactured by Junsei) are added, thoroughly mixed, and then mixed and pulverized using a colloid mill to complete an isoflavone paste. This isoflavone paste is placed in ^{a vacuum defoaming machine at 80 o} C and allowed to stand for 24 hours, and then air bubbles are removed and a soft capsule is manufactured with a laboratory soft capsule maker.

Example 3

Isoflavone Add 700 g of soy lecithin (manufactured by ADM) to 100 g of bioisoflavone powder (manufactured by SK Bioland), which is used as a raw material for health functional food, and slowly mix it with a food mixer. Add 300 g of linoleic acid and 10 g of Tween 80 and mix thoroughly. Then, it is mixed and pulverized using a colloid mill to complete the isoflavone paste. This isoflavone paste is placed in ^{a vacuum defoaming machine at 80 o} C and allowed to stand for 24 hours, and then air bubbles are removed and a soft capsule is manufactured with a laboratory soft capsule maker.

Example 4

Isoflavone Add 700 g of egg lecithin (manufactured by Kewpie) to 100 g of bioisoflavone powder (manufactured by SK Bioland), which is used as a raw material for health functional food, and slowly mix it with a food mixer. After mixing, mixing and grinding are performed using a colloid mill to complete an isoflavone paste. This isoflavone paste is placed in ^{a vacuum defoaming machine at 80 o} C and allowed to stand for 24 hours, and then air bubbles are removed and a soft capsule is manufactured with a laboratory soft capsule maker.

Example 5

200 g of bioisoflavone (manufactured by SK Bioland) and 100 g of equol-rich soybean fermented product were sufficiently pulverized with a ball mill to prepare microparticles, and 1500 g of soy lecithin, 100 g of olive oil and 50 g of Tween 60 were added. The mixture is gradually mixed with a food mixer, and then mixed and pulverized using a colloid mill to complete an isoflavone paste. This isoflavone paste is placed in ^{a vacuum defoaming machine at 80 o} C and allowed to stand for 24 hours, and then air bubbles are removed and a soft capsule is manufactured with a laboratory soft capsule maker.

Example 6

0.5 g of equol, 1 g of DZ, and 1 g of GN are mixed with 100 g of egg lecithin, 10 g of moonshine colostrum and 1 g of Tween 60, and then an isoflavone paste is completed. This isoflavone paste is placed in ^{a vacuum defoaming machine at 80 o} C and allowed to stand for 24 hours, and then air bubbles are removed and a soft capsule is manufactured with a laboratory soft capsule maker.

The component contents of Examples 1 to 6 are summarized in Table 1 below.

(Unit g) Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Isoflavones Bio isoflavones 100 100 100 100 200 Equol-rich soybean fermented product 100 Equol 0.5 DZ One GN One lecithin Soy lecithin 800 800 700 1500 Egg lecithin 50 50 700 100 maintain Oleic acid 100 200 Linoleic acid 300 Moonlight 300 olive oil 100 Moonshine colostrum 10 Hydrophilic surfactant Saponin 10 10 Tween 80 10 Tween 60 10 50 One

[Production Example]

Preparation Example 1: Isoflavone-fortified fermented red ginseng concentrate

20 g of the isoflavone paste of Example 1 was added to 100 g of fermented red ginseng concentrate (SK Bioland) and stirred well to emulsify. This emulsion is put in a plastic container for food to prepare an isflavone-fortified fermented red ginseng concentrate. This fermented red ginseng concentrate is suitable as a functional food for the elderly with weak immune function.

Preparation Example 2: Isoflavone-fortified soy milk

Add 1 L of water to a stirrer, stir slowly, add 130 g of raw soybean flour, heat and boil for 10 minutes, add 50 g of the isoflavone paste of Example 2, stir sufficiently, stop heating, place in an airtight container, and cool at room temperature. Produces isoflavone-fortified soymilk.

Preparation Example 3: Isoflavone-fortified chocolate

100 g of cocoa powder and 20 g of cocoa butter are placed in a glass container, slowly melted at 70 degrees, and mixed, then 90 g of nonfat milk and 20 g of sugar are added and sufficiently mixed to dissolve. Then, 20 g of the isoflavone paste of Example 1 was added and slowly stirred at 50 degrees for 2 hours. This chocolate undiluted solution is poured into a suitable mold and hardened to prepare isoflavone-enhanced chocolate.

Preparation Example 4: Isoflavone-enhanced gel-type health food

Add 25 g of gelatin, 10 g of agar, and 10 g of sugar to 500 ml of water ^{and dissolve at 90 °} C to prepare an aqueous gelatin/agar solution. 100 g of the isoflavone paste of Example 2 was added to this solution, and then sufficiently dispersed using a homomixer. The resulting isoflavone-enhanced gelatin/agar aqueous solution was cured at low temperature to prepare a gel-type health functional food.

[Experimental Example]

Experimental Example 1

To investigate the solubility of isoflavones in oil, lecithin, vitamin E, oleic acid, fish-derived omega-3, flaxseed oil, hemp seed oil, perilla oil, sesame oil, decoction oil, linoleic acid, soybean oil, grapeseed oil, palm oil, olive oil, 2 g of bioisoflavone (manufactured by SK Bioland) was placed in a glass container containing 10 g of lipids such as almond oil, malt oil, castor oil, avocado oil, moonshine colostrum oil, rosehill oil, shark liver oil, etc., and stirred at room temperature for 24 hours. The mixed lipid was centrifuged at high speed to precipitate particles, and then 0.5 ml of the supernatant was put into a glass bottle and diluted with 5 ml of xylene.

A 0.1% xylene standard solution of DZ and GN and a lipid mixture in which the isoflavone was dissolved were subjected to GC/MS analysis, and DZ and GN in the fat were quantitatively analyzed. As shown in Table 2, as a result of examining the concentrations of DZ and GN in fats and oils subjected to solubility experiments, the concentration in lecithin was significantly higher than that of other lipids. Therefore, it was found that the solubility was high.

maintain Isoflavone concentration (%) maintain Isoflavone concentration (%) DZ GN DZ GN lecithin 1.33 0.36 Sesame oil 0.13 0.02 Vitamin E 0.08 0.01 Moonlight 0.06 0.01 Oleic acid 0.08 0.01 Linoleic acid 0.06 0.01 Omega-3 0.06 0.01 Soybean oil 0.07 0.01 Flaxseed oil 0.07 0.01 Grapeseed oil 0.06 0.01 Hemp seed oil 0.06 0.01 palm oil 0.05 0.01 Perilla oil 0.10 0.02 Castor oil 0.08 0.01 olive oil 0.09 0.01 Avocado oil 0.06 0.01 Almond oil 0.06 0.01 Moonshine colostrum 0.07 0.01 Malt oil 0.07 0.01 Shark liver oil 0.06 0.01 Rose Hill You 0.10 0.02

Table 2 shows the concentrations of DZ and GN in fats and oils tested for dissolution at room temperature.

Experimental Example 2

Lecithin, vitamin E, oleic acid, fish-derived omega-3, flaxseed oil, hemp seed oil, perilla oil, sesame oil, decoction oil, linoleic acid, soybean oil, grapeseed oil, palm oil , Olive oil, almond oil, malt oil, castor oil, avocado oil, walnut colostrum oil, rosehill oil, shark liver oil, etc.In a glass container containing 10 g of each lipid, put 2 g of bioisoflavone (manufactured by SK Bioland) in a reactor at 80°C. It dissolved for 24 hours. The mixed lipid was centrifuged at high speed to precipitate particles, and then 0.5 ml of the supernatant was put into a glass bottle and diluted with 5 ml of xylene.

DZ and GN in the lipid were quantitatively analyzed by GC/MS analysis of the 0.1% xylene standard solution of DZ and GN and the lipid mixture in which the isoflavone was dissolved. As shown in Table 3, the solubility of lecithin was relatively low.

maintain Isoflavone concentration (%) maintain Isoflavone concentration (%) DZ GN DZ GN lecithin 3.15 0.60 Sesame oil 1.24 0.21 Vitamin E 1.23 0.20 Moonlight 1.14 0.23 Oleic acid 0.86 0.18 Linoleic acid 1.06 0.18 Omega-3 0.92 0.15 Soybean oil 0.90 0.14 Flaxseed oil 1.15 0.22 Grapeseed oil 0.86 0.12 Hemp seed oil 1.13 0.15 palm oil 0.75 0.11 Perilla oil 1.20 0.21 Castor oil 1.23 0.28 olive oil 1.11 0.15 Avocado oil 0.97 0.12 Almond oil 0.86 0.13 Moonshine colostrum 1.12 0.21 Malt oil 1.32 0.23 Shark liver oil 0.96 0.14 Rose Hill You 1.41 0.25

Table 3 shows the concentrations of DZ and GN in fats and oils tested for dissolution at ^80°C.

Experimental Example 3

To investigate the solubility of isoflavones in saponin and Tween-based surfactants, 2 g of bioisoflavones (manufactured by SK Bioland) were added to a glass container containing 10 g of food surfactants such as Tween 20, 40, 60 and 80. The mixture was stirred and dissolved at room temperature for 24 hours. The mixed surfactant was centrifuged at high speed to precipitate particles, and then 0.5 ml of the supernatant was put into a glass bottle and diluted with 5 ml of xylene.

A 0.1% xylene standard solution of DZ and GN and a surfactant mixture in which the isoflavone was dissolved were analyzed by GC/MS to quantitatively analyze DZ and GN in lipids. As shown in Table 4, it was higher than most of the lipids in Table 2.

Surfactants HLB Concentration (%) DZ GN Tween 20 16.7 0.19 0.01 Tween 40 15.6 0.23 0.08 Tween 60 14.9 0.36 0.01 Tween 80 15.0 0.65 0.03 Saponin (Junsei) 13.1 0.75 0.10

Table 4 shows the concentrations of DZ and GN of saponin and Tween-based surfactants subjected to solubility experiments at room temperature.

Experimental Example 4

In order to investigate the effect of fats and oils on the viscosity and isoflavone solubility of the isoflavone paste, the compositions of Comparative Examples in Table 5 and Examples 1 and 2 were compared with each other. The solubility investigation method was the same as in Experimental Example 1, and the absolute viscosity was measured with a Brookfield viscometer (spindle s64 (LV4), rotational speed of 50 rpm).

Composition Comparative example Example 1 Example 2 Bioisoflavone 100 100 100 Soy lecithin 800 800 800 Egg lecithin 50 50 50 Oleic acid 0 100 200 Saponin 10 10 10

As shown in FIG. 1, as the content of oleic acid increased, the concentration of dissolved isoflavone in the sample decreased, so that the solubility seemed to decrease somewhat, but it is believed that it does not have a significant effect. On the other hand, the absolute viscosity showed a sharp decrease by the addition of oleic acid. Therefore, when manufacturing soft capsules of isoflavone paste, mixing oils and fats such as oleic acid is very useful.

Experimental Example 5

In order to investigate the bioabsorbability of isoflavone paste, isoflavone powder and isoflavone paste were compared pharmacokinetics. At this time, the experimental group dispersed the isoflavone paste of Example 1 in purified water at a concentration of 30%, and the comparative group used the isoflavone powder dispersed in purified water to have the same concentration.

The experimental animals were 10-week-old Sprague-Dawley female rats, and the isoflavone dose per sample was 10 mg/kg, and the isoflavone blood concentration was measured at 1, 2, and 6 hours after administration.

As seen from the pharmacokinetic results of FIG. 2, the isoflavone concentration in the plasma of the isoflavone paste (Example 1) suspension was relatively high, and the bioabsorption rate was higher than that of the isoflavone powder suspension (comparative group) Sum) was analyzed to be relatively high in body absorption.

In the above, embodiments of the present invention have been described with reference to the accompanying drawings, but those of ordinary skill in the art to which the present invention pertains can be implemented in other specific forms without changing the technical spirit or essential features of the present invention. You can understand that there is. Therefore, it should be understood that the embodiments described above are illustrative in all respects and are not limiting.

Claims (6)

In the composition with improved bioabsorption rate of isoflavone, the composition
Isoflavones; lecithin; Hydrophilic surfactants; And maintenance; including,
The isoflavone, lecithin, hydrophilic surfactant and fat are included in a weight ratio of 1: 6.5 to 9: 0.07 to 0.15: 0.8 to 3.5,
The isoflavone is present in the composition in a form dissolved by lecithin acting as a solvent,
The composition is a soft capsule formulation,
Composition with improved bioabsorption of isoflavone
The method of claim 1,
The isoflavones are daidzein (daidzein), genistein (genistein) and a composition comprising any one or more of equal (equol), the bioabsorption rate of isoflavone is improved.
The method of claim 1,
The lecithin is a composition comprising at least one of soy-derived lecithin and egg-derived lecithin, wherein the bioabsorption rate of isoflavone is improved.
The method of claim 1,
The hydrophilic surfactant is saponin, a composition with improved bioabsorption of isoflavones.
The method of claim 1,
The isoflavone is daidzein or genistein,
The lecithin is soy-derived lecithin or egg-derived lecithin,
The hydrophilic surfactant is saponin,
The fat or oil is oleic acid, a composition with improved bioabsorption rate of isoflavone.
The method of claim 1,
The isoflavone, lecithin, hydrophilic surfactant, and oil are 1: 7 to 9: 0.07 to 0.13: It is contained in a weight ratio of 0.8 to 2.5, the bioabsorption rate of isoflavone is improved.

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