KR20200127090A - Tracheal tube composition for removal of biofouling - Google Patents

Abstract

The present invention relates to a composition for a tracheal tube having a biofouling removal function, and more specifically, to a composition for a tracheal tube which provides a biofouling removal function by having conductivity even at a low voltage. The composition for a tracheal tube of the present invention has a function of preventing agglomeration of mucus by a low voltage electrical signal, thereby preventing clogging of the tube by phlegm and the like and prolonging the replacement cycle of the tube.

Description

Composition for tracheal tube composition for removal of biofouling

The present invention relates to a composition for a tracheostomy tube having a biological contamination removal function. More specifically, it relates to a composition for a tracheostomy tube exhibiting a function of removing biofouling by having conductivity even at a low voltage.

Today, with the development of intensive care technology, the survival rate of patients is increasing, and when mouth breathing is not possible due to various causes, breathing is often maintained by orotracheal intubation or tracheostomy, resulting in airway. Complications from intubation or tracheostomy are also increasing.

In addition, even when artificial respiration is required due to respiratory infections such as pneumonia, tracheostomy is performed when long-term airway intubation is expected for 2 weeks or more.If the secretions present in the patient's airways are not removed in time, the tube is blocked by the secretions ( obstruction), and if tube replacement and obstruction are not resolved within minutes, there is a problem that may lead to brain damage or death due to hypoxia.

In particular, in the case of children, since the inner diameter of the tracheostomy tube is very small, even a slight mucus adhesion causes severe breathing difficulties, so development of a tracheostomy tube that can fundamentally reduce mucus adhesion is required. In addition, there is a risk of infection in the bronchi when external substances are introduced through the tracheostomy tube, and there is an urgent need to develop a technology that can prevent infection by controlling the physicochemical properties inside the tube, while preventing obstruction by mucus. Actually.

Currently, tracheostomy tubes produced and sold at home and abroad are medical polymer tubes, and no secretion removal or obstruction prevention technology has been applied. Conventional tracheostomy tubes are known to use silicone materials or polyvinyl chloride (PVC) materials, which are known to have low surface energy and minimize the adhesion of biomaterials. Despite the use of these materials, tube blockages are continuously reported. It is difficult to attach or remove biomaterials such as mucus with the material itself.

Biofouling is a phenomenon in which microorganisms (bacteria) adhere to the bottom of a ship, heat exchangers of power plants, marine structures, medical devices, etc. to form a biofilm, and then various species adhere to the structure and affect the structure. In particular, in the case of a tube-type medical device, the formation of a biofilm due to biofouling causes problems such as clogging of the tube and secondary infection by bacteria.

In order to solve the above problem, the present inventors have invented a composition for a tracheostomy tube that exhibits conductivity even at a low voltage and thus has a biofouling function.

Republic of Korea Patent Registration No. 10-1599426 (Name of the invention: butenolide-based compound and its manufacturing method and pharmaceutical composition containing the same, Applicant: Seoul National University Industry-Academic Cooperation Foundation, Registration: 2016.02.25.)

Lee et. al., Appl. Chem. Eng., 2012, 23, 71-76 Park et. al., Journal of Korean Crystal Growth and Crystal Technology, 2015, 25, 212-217

An object of the present invention is to provide a composition for a tracheostomy tube having a biological contamination removal function. It is characterized in that it exhibits the effect of removing biocontaminants from the composition for tracheostomy tubes through current by applying a voltage, and more specifically, a composition for tracheostomy tubes that exhibits a function of removing biofouling by having conductivity even at a lower voltage. It is in providing.

The present invention relates to a composition for a tracheostomy tube having a biological contamination removal function.

The composition for the tracheostomy tube may include polyurethane, carbon black, and polypyrrole.

The carbon black may have a DBP absorption rate of 350 ~ 385 ㎖/100g.

The polypyrrole may be a solid sample in the form of a pellet having a conductivity of 10 to 50 s/cm.

In addition, the polyurethane, carbon black and polypyrrole may include 25 to 30 parts by weight of carbon black and 15 to 35 parts by weight of polypyrrole based on 100 parts by weight of polyurethane.

The polyurethane, carbon black and polypyrrole may be prepared by dissolving in methylpyrrolidone at 60 to 80° C. and drying for 12 to 24 hours.

In addition, the composition for the tracheostomy tube may have a biofouling removal function.

The composition for tracheostomy tube may have a biofouling function by applying a voltage.

Another invention relates to a tracheostomy tube for removing biofouling, characterized in that made of the composition for the tracheostomy tube.

Hereinafter, the present invention will be described in detail.

The composition for tubes of the present invention may include 25 to 30 parts by weight of carbon black and 15 to 35 parts by weight of polypyrrole based on 100 parts by weight of polyurethane.

The polyurethane may be a polymer material produced by a urea reaction by bonding of an isocyanate group and a polyol. Polyurethane can be manufactured in a wide variety from high hardness plastics to highly flexible foams in the range of specific gravity 6kg/㎥ to 1220kg/㎥. The polyurethane has a weight average molecular weight (Mw) measured by gel permeation chromatography (GPC) of 3,000 to 400,000, and more preferably 6,000 to 80,000. Further, the acid value is preferably 5 to 120 mgKOH/g, more preferably 10 to 60 mgKOH/g.

The polyurethane includes a two-component coating catalyst curing type and a polyol curing type coating. More suitably, it is best to use a polyol curing type coating that forms a strong three-dimensional network structure by easily reacting polyol and polyisocyanate at room temperature. desirable. In addition, in the two-component polyol curable paint, there are three types of polyols: polyester, polyether, and polyacrylate. The molecular structure, molecular weight, functional group and crosslinking density can be arbitrarily adjusted, and polyurethane can be produced by combining with polyisocyanate. It is more preferable to use polyester, which has the advantage of easily converting the properties of the coating film. In addition, benzoic acid-modified polyester is used to lower the average functional degree of the reaction system, facilitate control of molecular weight and viscosity, and improve physical properties such as hardness, adhesion, color gloss, drying time and chemical resistance of the coating film. The content of benzoic acid is appropriate about 5 to 30% by weight, preferably 15 to 20% by weight, based on the total amount of polyester. There is an advantage in that the solid content increases as the benzoic acid content increases, but it can be seen that the level of relative viscosity decrease decreases above an appropriate level.

In addition, the polyol for the synthesis of the polyurethane uses a benzoic acid-modified polyester, and the content thereof is suitably 20 to 40% by weight, preferably 25 to 35% by weight. As the isocyanate, it is recommended to use isophorone diisocyanate (IPDI, isophorone diisocyanate), which is commonly used, and the content may be 5 to 20% by weight, and 5 to 15% by weight is most preferable. Meanwhile, 2,2-bis(hydroxymethyl)propionic acid (DMPA) may be used to introduce a hydrophilic group. As the content of DMPA increases, the initial particle size decreases, and as the concentration of the ionic group in the continuous phase increases, the final particle size increases, and the concentration of the stabilizeable hydrophilic group increases, but the optimum degree of chain extension decreases. When the content of DMPA is low, the storage properties are poor, and when the content of DMPA is high, the properties of the coating film are deteriorated during painting. Therefore, the content of DMPA for maintaining optimal performance is appropriate in a range of 0.3 to 5% by weight, and preferably 0.5 to 2% by weight. In addition, 0.5 to 2% by weight of N-methyl-2-pyrrolidone (NMP) is used as a solvent for the DMPA. Dibutyltin dilaurate (DBTL), a tin (Sn)-based catalyst, is used as the reaction catalyst of the polyurethane prepolymer, and triethylamine (TEA) is used as the neutralizing agent, and 0.5 to 2% by weight is preferable. In addition, deioninzed water was used in all experimental steps. At this time, 35 to 55% by weight of ultrapure water was used.

It is preferable to use the carbon black having a DBP absorption rate of 350 to 385 ml/100g. DBP (Dibutyl phthalate) absorption rate is used as an index to confirm the aggregate size of carbon black, and indicates the degree to which dibutyl phthalate (DBP) is absorbed into carbon black. If the carbon black has a DBP absorption rate of less than 350 ml/100g, it may not exhibit conductivity or have inadequate decontamination effect when the composition for tubes is prepared, and when the DBP absorption rate is more than 385 ml/100g, the surface may be rough or Cracks can form, which is undesirable.

In addition, if the composition for tubes is less than 25 parts by weight of carbon black based on 100 parts by weight of polyurethane, it may not exhibit conductivity or may have insufficient stain removal effect, and if it exceeds 30 parts by weight, the surface may be rough or cracked when preparing the composition for tubes. It may be formed, which is not desirable.

In addition, the composition for the tube preferably contains 15 to 35 parts by weight of polypyrrole based on 100 parts by weight of polyurethane. If the amount of polypyrrole based on 100 parts by weight of polyurethane is less than 15 parts by weight, the conductivity may be low, and the stain removal effect may be insufficient, and if it exceeds 35 parts by weight, the surface may be rough or holes may be formed when preparing the tube composition, which is not preferable. More preferably, a composition for tubes containing 25 to 35 parts by weight of polypyrrole based on 100 parts by weight of polyurethane is most preferred because it has excellent biofouling effect.

The composition for tubes of the present invention is prepared by dissolving polyurethane, carbon black, and polypyrrole in methylpyrrolidone at 60 to 80°C and drying for 12 to 24 hours. It may be manufactured.

If polyurethane, carbon black and polypyrrole are added to the methyl pyrrolidone and then melted at less than 60° C., polyurethane, carbon black and polypyrrole are not sufficiently dispersed, so that when preparing a composition for a tube, it may not exhibit conductivity or have insufficient stain removal effect. have. In addition, melting exceeding 80° C. is undesirable because polyurethane, carbon black and polypyrrole may be deformed.

On the other hand, the composition for tubes of the present invention may exhibit a biofouling effect by applying a voltage. Preferably, 0.02 to 0.04A flows at a voltage of 2V or less, and through this, it is possible to exhibit an effect of removing biofouling.

The present invention relates to a composition for a tracheostomy tube having a biological contamination removal function. It is equipped with a function to prevent agglomeration of mucus by a low-voltage electrical signal to prevent clogging of the tube by phlegm and the like, and to prolong the replacement cycle of the tube.

1 is a photograph comparing the surfaces of a tube composition prepared by adding carbon black having different DBP absorption rates prepared in Experimental Example 1 according to the present invention.
2 is a photograph comparing the surface of a composition for tubes formed according to the content of carbon black prepared in Experimental Example 2 according to the present invention.
3 is a photograph comparing the surface of a composition for tubes formed according to the content of polypyrrole prepared in Experimental Example 3 according to the present invention.
Figure 4 is a graph showing the current change of the composition for a tube with respect to the polypyrrole content when the content of polyurethane and carbon black carried out in Experimental Example 3 according to the present invention is constant.
5 is a graph showing the biofouling removal rate with respect to the content of polypyrrole carried out in Experimental Example 4 according to the present invention.

Hereinafter, a preferred embodiment of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, it is provided to sufficiently convey the spirit of the present invention to those skilled in the art so that the contents introduced herein are thorough and complete.

Experimental Example 1. Selection of appropriate carbon black

First, methylpyrrolidone (1-methyl-2-pyrrolidone), polyurethane (polyurethane) and carbon black were prepared to prepare a composition for a tube.

1 g of polyurethane, 0.4 g, and 0.05 g of carbon black were added to each 10 ml methylpyrrolidone, put in a glass petri-dish (diameter 7.6 cm), and dried on a hot plate at 70° C. for 12 hours to prepare a tube composition. Was prepared. At this time, carbon black was prepared by using those having dibutyl phthalate (DBP) absorption rates of 370 ml/100g and 500 ml/100g, respectively, and are shown in Table 1 below. In addition, a photograph of the surface of the prepared tube composition is shown in FIG. 1.

division Polyurethane Carbon black DBP absorption rate of carbon black Experimental Example 1-1 1g 0.40g 370ml/100g Experimental Example 1-2 1g 0.40g 500ml/100g Experimental Example 1-3 1g 0.05g 370ml/100g Experimental Example 1-4 1g 0.05g 500ml/100g

Referring to FIG. 1, it can be seen that each tube composition (Experimental Examples 1-1 and 1-2) prepared by adding 0.40 g of carbon black was not well formed and cracked. Among them, it can be seen that the composition for tubes (Experimental Example 1-2) to which carbon black having a DBP absorption rate of 500 ml/100 g was added was more severely cracked. In addition, as a result of measuring the conductivity of the composition for each tube, it was confirmed that a current flows.

Each tube composition prepared by adding 0.05 g of carbon black (Experimental Examples 1-3 and 1-4) can be seen that the tube composition was well formed. Among them, the composition for tubes to which carbon black with a DBP absorption rate of 500 ml/100 g is added forms a rougher surface, so it is thought that carbon black with a DBP absorption rate of 370 ml/100 g is better dispersed in methylpyrrolidone. However, the difference in conductivity between the carbon black having a DBP absorption rate of 370 ml/100g and carbon black having a DBP absorption rate of 370 ml/100 g and 500 ml/100 g by confirming that no current flows as a result of measuring the conductivity of the tube compositions of Experimental Examples 1-3 and 1-4 In the following experimental example, a composition for a tube containing carbon black having a DBP absorption rate of 370 ml/100 g was prepared and tested.

Experimental Example 2. Confirmation of the proper ratio of carbon black

After Experimental Example 1, a composition for tubes containing 370ml/100g of carbon black was prepared in the same manner as in Experimental Example 1 in order to check the appropriate ratio of carbon black, but the content of carbon black was varied. 1 g of polyurethane and 0.08 g, 0.10 g, 0.15 g, 0.20 g, 0.25 g and 0.30 g of carbon black based on polyurethane were added to 10 ml of methylpyrrolidone, respectively, and free petri-dish (diameter 7.6 cm) Put in and dried for 12 hours on a 70 ℃ hot plate to prepare a composition for tubes. This is shown in Table 2 below, and a photograph of the surface of the prepared tube composition is shown in FIG. 2.

division Polyurethane Carbon black DBP absorption rate of carbon black Experimental Example 2-1 1g 0.08g 370ml/100g Experimental Example 2-2 1g 0.10g 370ml/100g Experimental Example 2-3 1g 0.15g 370ml/100g Experimental Example 2-4 1g 0.20g 370ml/100g Experimental Example 2-5 1g 0.25g 370ml/100g Experimental Example 2-6 1g 0.30g 370ml/100g Experimental Example 2-7 1g 0.35g 370ml/100g

Referring to FIG. 2, as the content of carbon black increases, the composition for tubes cannot be formed and the cracking becomes severe, but the composition for tubes prepared by adding carbon black having a DBP absorption rate of 370 ml/100g cracks even when the content of carbon black is high. It can be seen that it is a smooth surface without this. Although not shown in FIG. 2, Experimental Example 2-6 with a carbon black content of 0.30g was not ground but was confirmed to have a rough surface, and the tube composition of Experimental Example 2-7 with a carbon black content of 0.35g was cracked. Since it was formed, it was judged that the content of carbon black based on 1 g of polyurethane should be 0.30 g or less.

In addition, as a result of measuring the conductivity of the composition for tubes of Experimental Examples 2-1 to 2-7, the content of carbon black was 0.01 to 0.03 A when voltage was applied from 0.15 g or more to 10 V, and the content of carbon black was 0.25 When the voltage was greater than g, it was confirmed that 0.01A flows when a voltage of 5V is applied. Therefore, for a low-voltage module, the content of carbon black must be 0.25g or more, but it is determined that a binder capable of connecting conductive domains is needed to increase the conductivity.

Experimental Example 3. Checking the proper content of the binder (polypyrrole)

As confirmed in Experimental Example 2, the content of carbon black should be 0.25g or more, and it was confirmed that a binder is required to prevent cracking of the tube composition. Therefore, in this experiment, a composition for a tube was prepared by additionally adding polypyrrole as a binder.

First, 1 g of polyurethane and 0.25 g of carbon black having a DBP absorption rate of 370 ml/100 g were added to 10 ml of methylpyrrolidone, and polypyrrole 0.02g, 0.03g, 0.04g, 0.05g, 0.07g, 0.09g, 0.15g, 0.25g, 0.35g, 0.40g and 0.45 were each additionally added. At this time, polypyrrole was used as a solid sample in the form of pellets having a conductivity of 10 to 50 s/cm. This was put in a glass petri-dish (diameter 7.6cm) and dried on a hot plate at 70° C. for 12 hours to prepare a tube composition, which is shown in Table 3 below. In addition, a photograph of the surface of the prepared tube composition is shown in FIG. 3, and a specific graph of conductivity is shown in FIG. 4.

division Polyurethane Carbon black DBP absorption rate of carbon black Polypyrrole Experimental Example 3-1 1g 0.25g 370ml/100g 0.02g Experimental Example 3-2 1g 0.25g 370ml/100g 0.03g Experimental Example 3-3 1g 0.25g 370ml/100g 0.04g Experimental Example 3-4 1g 0.25g 370ml/100g 0.05g Experimental Example 3-5 1g 0.25g 370ml/100g 0.07g Experimental Example 3-6 1g 0.25g 370ml/100g 0.09g Experimental Example 3-7 1g 0.25g 370ml/100g 0.15g Experimental Example 3-8 1g 0.25g 370ml/100g 0.25g Experimental Example 3-9 1g 0.25g 370ml/100g 0.35g Experimental Example 3-10 1g 0.25g 370ml/100g 0.40g Experimental Example 3-11 1g 0.25g 370ml/100g 0.45g

Referring to FIG. 3, when the polypyrrole is increased from 0.02 g to 0.45 g in 0.25 g of carbon black based on 1 g of polyurethane, the surface becomes smoother until the composition for tubes containing 0.35 g of polypyrrole, but the composition for tubes containing 0.40 g From then on, it can be seen that the surface gradually becomes rough and pores begin to form in the tube composition containing 0.45g polypyrrole. This is because the solubility in methylpyrrolidone decreases as the content of polypyrrole increases, and the aggregation of polypyrrole decreases. It is judged that the surface is roughened or holes are formed due to the severe condition. Therefore, it is considered that the composition for tubes in which 0.40 g or more of polypyrrole based on 1 g of polyurethane is added is not desirable to use.

Meanwhile, referring to FIG. 4, as a result of measuring the conductivity of the tube compositions of Experimental Examples 3-1 to 3-11, it was confirmed that the conductivity increased as the content of the conductive polymer polypyrrole increased. In particular, it can be seen that 0.04A flows at 2.0V for the tube composition to which 0.15g or more of polypyrrole is added. Therefore, it can be seen that the introduction of polypyrrole acts as a binder that can prevent the tube composition from cracking, thereby effectively forming a tube composition having a function of driving at a low voltage.

Example 1. Preparation of composition for tubes

Through the Experimental Examples 1 to 3, it was possible to know the optimum ratio of raw materials for preparing a composition for a tube having conductivity even at a low voltage.

First, methylpyrrolidone (1-methyl-2-pyrrolidone), polyurethane (polyurethane), polypyrrole (polypyrrole) and carbon black were prepared to prepare a tube composition.

1 g of polyurethane, 0.35 g of polypyrrole and 0.25 g of carbon black were added to 10 ml of methylpyrrolidone, put in a glass petri-dish (diameter 7.6 cm), and dried on a hot plate at 70° C. for 12 hours to prepare a tube composition. . At this time, carbon black was used having a DBP absorption rate of 350 ~ 385 ㎖ / 100g, which is shown in Table 4 below.

division Contents Example 1-1 Composition for tubes made of carbon black with a DBP absorption rate of 350 ml/100g Example 1-2 Composition for tubes made of carbon black with a DBP absorption rate of 360 ml/100g Example 1-3 Composition for tubes made of carbon black with a DBP absorption rate of 370 ml/100g Example 1-4 Composition for tubes made of carbon black with DBP absorption rate of 385 ml/100g

Comparative Example 1. Preparation of a composition for tubes containing carbon black with different DBP absorption rates

A composition for tubes was prepared in the same manner as in Example 1, but to which carbon black having a different DBP absorption rate was added. Instead of carbon black having a DBP absorption rate of 350 to 385 ml/100g, a composition for a tube was prepared using carbon black having a different DBP absorption rate, which is shown in Table 5 below.

division Contents Comparative Example 1-1 Composition for tubes made of carbon black with a DBP absorption rate of 330 ml/100g Comparative Example 1-2 Composition for tubes made of carbon black with a DBP absorption rate of 400 ml/100g Comparative Example 1-3 Composition for tubes made of carbon black with a DBP absorption rate of 450 ml/100g Comparative Example 1-4 Composition for tubes made of carbon black with a DBP absorption rate of 500 ml/100g Comparative Example 1-5 Composition for tubes made of carbon black with DBP absorption rate of 520 ml/100g

Comparative Experimental Example 1. Comparison of the surface of the composition for tubes and confirmation of conductivity

The surface conditions and conductivity of the compositions for tubes prepared in Example 1 and Comparative Example 2 were evaluated. When evaluating the surface condition of the tube composition, if the surface is soft, "◎", if the surface is rough or cracked, "X" is used. The evaluation of conductivity is evaluated as "◎" if it shows conductivity, otherwise it is evaluated as "×". And it is shown in Table 6 below.

division Surface condition Check conductivity Example 1-1 ◎ ◎ Example 1-2 ◎ ◎ Example 1-3 ◎ ◎ Example 1-4 ◎ ◎ Comparative Example 1-1 × × Comparative Example 1-2 × × Comparative Example 1-3 × × Comparative Example 1-4 × × Comparative Example 1-5 × ×

Referring to Table 6, the tube compositions of Examples 1-1 to 1-4 prepared by adding carbon black having a DBP absorption rate of 350 to 385 ml/100g did not have a rough surface or formed cracks. It can be seen that it shows conductivity when voltage is applied. On the other hand, the composition for tubes of Comparative Example 1-1 prepared by adding carbon black having a DBP absorption rate of 330 ml/100g or Comparative Examples 1-2 to 1- prepared by adding carbon black having a DBP absorption rate of 400 ml/100g or more. It can be seen that the composition for tubes of 5 forms cracks on the surface and has no conductivity.

Therefore, it was confirmed that the surface condition and the presence or absence of conductivity of the tube composition were changed according to the DBP absorption rate of carbon black.

Experimental Example 4. Confirmation of biofouling ability of the composition for tubes

The biofouling ability of the tube composition prepared in Experimental Example 3 was confirmed.

Since there is no known method for removing biofouling by biological mucus,'Self-cleaning and antibiofouling enamel surface by slippery liquidinfused technique' Scientific Reports 6 (2016) 25924 and "Biofilm formation of Candida albicans on implant overdenture materials and its removal" The experiment was conducted by modifying the method described in the journal of dentistry 40 (2012) 686-692 to analyze the amount of biofouling substances washed out from the surface of the tube composition.

First, the composition for each tube was cut into 1cm×1cm size and prepared, and 1g of mucin was added to 10ml of distilled water, and 20µl of the dissolved solution was dropped onto the composition for each tube and dried in the air for about 3 hours. At this time, mucin was used as a replacement for biofouling substances.

Thereafter, the electrode was applied to the tube composition in a dark room and the substrate was driven at 2V for 3 hours. After driving, 20 µl of Alcian blue was dropped on the mucin and dried in air for 2 hours to stain the mucin.

After putting the composition for each tube into an amber vial having a size of 20 ml, 3.5 ml of hydrogen peroxide (Samchun 30-36%) was added and ultrasonically pulverized for 10 minutes. Shown in.

Referring to FIG. 5, it can be seen that the intensity of UV-vis absorption at λ _max = 613 nm of a solution in which 20 µl of Alcian Blue is dissolved in 3.5 ml of hydrogen peroxide is 1. The amount of Alcian Blue in hydrogen peroxide obtained from each tube composition can be determined by Beer-Lambert's law, and the contamination rate was determined from the absorption intensity at λ _max = 613 nm of Alcian Blue of each hydrogen peroxide.

It can be seen that as the content of polypyrrole in the tube composition increases, the absorption intensity of Alcian Blue increases, so that Alcian Blue is more washed out by the hydrogen peroxide solution. It can be seen that the absorption intensity of Alcian Blue in the tube composition of Experimental Example 3-9 to which 35% of polypyrrole was added based on 1 g of polyurethane was the highest, and this was the amount remaining after the mucin attached to the tube composition was removed You can see that it is the least effective and the most effective. On the other hand, the low absorption intensity of Alcian Blue means that the amount of mucin remaining in the tube composition is large, and thus the contamination removal rate is low.

In particular, it can be seen that the stain removal effect of the composition for a tube according to the present invention is very excellent through showing a stain removal rate of about 7 times that of the composition for a pure polyurethane tube that does not contain a conductive material.

Claims (8)

Polyurethane (Polyurethane), carbon black and polypyrrole (Polypyrrole), characterized in that the composition for tracheostomy tube comprising a. The method of claim 1,
The carbon black is a composition for tracheostomy tubes, characterized in that the DBP absorption rate is 350 ~ 385 ㎖ / 100g. The method of claim 1,
The polypyrrole is a composition for tracheostomy tube, characterized in that the solid sample in the form of a pellet having a conductivity of 10 ~ 50s / cm. The method of claim 1,
The polyurethane (Polyurethane), carbon black and polypyrrole (Polypyrrole) is a composition for tracheostomy tube, characterized in that it comprises 25 to 30 parts by weight of carbon black and 15 to 35 parts by weight of polypyrrole based on 100 parts by weight of polyurethane. The method of claim 1,
An engine characterized in that the polyurethane (Polyurethane), carbon black and polypyrrole (Polypyrrole) is dissolved in methylpyrrolidone (1-methyl-2-pyrrolidone) at 60 to 80 ℃ and dried for 12 to 24 hours Composition for incision tubes. The method according to any one of claims 1 to 5,
The composition for tracheostomy tubes is a composition for tracheostomy tubes, characterized in that it has a biological contamination removal function. The method of claim 6,
The composition for tracheostomy tubes is a composition for tracheostomy tubes, characterized in that it has the functionality of removing biofouling by applying a voltage. The tracheostomy tube for removing biofouling, characterized in that manufactured according to any one of claims 1 to 7.

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