KR20200095969A - Apparatus and method for generating three dimensional voltage difference atrium model - Google Patents

Abstract

According to an embodiment of the present invention, a method for generating a three-dimensional voltage difference atrium model to allow an apparatus for generating a three-dimensional voltage difference atrium model for atrial fibrillation electrode catheter ablation to determine the high-frequency energy intensity of atrial fibrillation electrode catheter ablation comprises: (a) a step of receiving a voltage of a measurement electrode and a voltage of a reference electrode measured by a catheter including a plurality of electrodes and allowing the plurality of electrodes to come in contact with a plurality of specific points included in an atrium while inserted into the heart to calculate a single-pole voltage at the plurality of specific points included in the atrium; (b) a step of calculating an anode voltage at the plurality of specific points included in the atrium based on the received voltage of the measurement electrode measured at the plurality of specific points including in the atrium; (c) a step of calculating a voltage difference of the measured single-pole voltage and anode voltage at the plurality of specific points included in the atrium; and (d) a step of displaying the calculated voltage difference of the single-pole voltage and the anode voltage at the plurality of specific points included in the atrium on a three-dimensional atrium model to generate a three-dimensional voltage difference atrium model.

Description

3D voltage difference atrial model generation device and generation method {APPARATUS AND METHOD FOR GENERATING THREE DIMENSIONAL VOLTAGE DIFFERENCE ATRIUM MODEL}

The present invention relates to an apparatus and a method for generating a three-dimensional voltage difference atrial model. In more detail, the present invention relates to an apparatus and method capable of generating a three-dimensional voltage difference atrial model for determining the high frequency energy intensity of atrial fibrillation electrode catheterectomy.

Arrhythmia is a symptom in which the heart beats abnormally faster, slower, or irregularly due to the fact that the electrical stimulation of the heart is poor or the stimulus is not delivered properly, and regular contraction cannot continue. Provides the cause of stroke or stroke.

As a treatment method for arrhythmia, there is a surgical therapy that blocks the electrical conduction of the heart by cauterizing the heart tissue, such as atrial fibrillation electrode catheterectomy, to prevent arrhythmia. However, resection is performed at a certain part of the heart with a certain amount of high-frequency energy intensity. There is a problem in that it is difficult to grasp in advance whether the optimal effect can be derived only by implementation.

The problem of this high-frequency electrode catheter ablation can be solved if the thickness of the heart is known in advance, and the part with a thin thickness is performed with weaker high-frequency energy, and the part with a thicker thickness is stronger than this. This is because the optimal effect can be derived by performing an ablation procedure with high-frequency energy of intensity, and accordingly, methods of determining the thickness of the heart through various means have been actively studied in recent years.

On the other hand, the thickness of the heart can be estimated through the voltage difference at each point of the heart, because it has been physiologically proven that the thickness of the heart is thick at the point where the voltage difference is high, and the thickness of the heart is thin at the point where the voltage difference is low. Therefore, the thickness of the heart can be easily estimated by implementing a 3D heart model that accurately expresses the voltage difference at all points of the heart.

The present invention relates to an apparatus and method for quickly and simply generating a three-dimensional voltage difference atrial model capable of estimating the voltage difference of the heart, more specifically, the thickness of the heart by reflecting these items.

Republic of Korea Patent Publication No. 10-2010-0111234 (2010.10.14)

The technical problem to be solved by the present invention is to provide an apparatus and method capable of generating a three-dimensional voltage difference atrial model capable of estimating the thickness of a heart prior to atrial fibrillation electrode catheterectomy.

Another technical problem to be solved by the present invention is to provide an apparatus and method capable of quickly and easily generating a three-dimensional voltage difference atrial model capable of estimating the thickness of a heart.

The technical problems of the present invention are not limited to the technical problems mentioned above, and other technical problems not mentioned will be clearly understood by a person skilled in the art from the following description.

A three-dimensional voltage-difference atrial model for determining the high frequency energy intensity of atrial fibrillation electrode catheterctomy according to an embodiment of the present invention for achieving the above technical task The method of generating (a) includes a plurality of electrodes, and the voltage and measurement of the reference electrode measured by a catheter in which the plurality of electrodes are in contact with a plurality of specific points included in the atrium while being inserted into the heart Receiving the voltage of the electrode, calculating a unipolar voltage at a plurality of specific points included in the atrium, (b) based on the voltage of the measurement electrode measured at a plurality of specific points included in the received atrium, Calculating anode voltages at a plurality of specific points included in the atrium, (c) calculating a voltage difference between monopole voltages and anode voltages at a plurality of specific points included in the measured atrium, and (d) And generating a three-dimensional voltage difference atrial model by displaying a voltage difference between a unipolar voltage and an anode voltage at a plurality of specific points included in the calculated atrium on a three-dimensional atrial model.

According to an embodiment, the catheter may include 10 electrodes.

According to an embodiment, the step (a) comprises: (a-1) the voltage of the reference electrode and the measurement electrode at a plurality of specific points included in the atrium measured at intervals of 1 ms to 2000 ms by the catheter. It may include receiving a voltage of.

According to an embodiment, in step (a), (a-2) a difference (Peak to Peak) between the highest measured voltage and the lowest measured voltage within the predetermined time interval is determined as the voltage of the measuring electrode. It may include the step of.

According to an embodiment, the step (b) includes (b-1) a difference in voltage of the determined measuring electrode for each of two electrodes separated by 2.5 mm from among a plurality of electrodes included in the catheter. It may include the step of calculating as.

According to an embodiment, the step (a) includes: (a-3) calculating a voltage difference between the voltage of the reference electrode and the voltage of the measurement electrode at a plurality of specific points included in the received atrium as the single-pole voltage. It may include steps.

According to an embodiment, the reference electrode may be in contact with a point spaced apart by a predetermined distance so as not to affect the voltage measurement of the measurement electrode to measure the voltage of the reference electrode.

According to an embodiment, after the step (d), the step (e) may further include determining whether the step (c) has been performed a predetermined number of times or more.

According to an embodiment, as a result of the determination in step (e), if it is not performed more than a predetermined number of times, (f) a plurality of specific points included in the atrium are changed to a plurality of different specific points, and the step (a) It may further include a step of returning to.

According to an embodiment, if the determination result in step (e) is performed more than a predetermined number of times, (g) the voltage difference between the monopole voltage and the anode voltage at a plurality of specific points displayed in the generated 3D voltage difference atrial model The step of displaying the voltage difference at all points of the three-dimensional voltage difference atrial model by applying a linear interpolation method may be further included.

The apparatus for generating a three-dimensional voltage difference atrial model according to another embodiment of the present invention for achieving the above technical problem is at least one processor. A network interface, a memory for loading a computer program executed by the processor, and a storage for storing large-capacity network data and the computer program, wherein the computer program includes: (a) a plurality of electrodes, and A plurality of specific points included in the atrium by receiving the voltage of the reference electrode and the voltage of the measurement electrode measured by the catheter in which the plurality of electrodes are in contact with a plurality of specific points included in the atrium while being inserted into the atrium The operation of calculating the unipolar voltage at, (b) calculating the anode voltage at a plurality of specific points included in the atrium based on the voltages of the measurement electrodes measured at a plurality of specific points included in the received atrium. Operation, (c) an operation of calculating the voltage difference between the unipolar voltage and the anode voltage at a plurality of specific points included in the calculated atrium; and (d) the unipolar voltage at a plurality of specific points included in the calculated atrium; It includes an operation of generating a three-dimensional voltage difference atrial model by displaying the voltage difference of the anode voltage on a three-dimensional atrial model.

A computer program stored in a medium according to another embodiment of the present invention for achieving the above technical problem is combined with a computing device, (a) including a plurality of electrodes, and the plurality of electrodes are inserted into the heart. Receiving the voltage of the reference electrode and the voltage of the measurement electrode measured by a catheter in contact with a plurality of specific points included, and calculating a unipolar voltage at a plurality of specific points included in the atrium, (b ) Calculating anode voltages at a plurality of specific points included in the atrium based on voltages of measurement electrodes measured at a plurality of specific points included in the received atrium, (c) including the calculated atrium Calculating the voltage difference between the monopole voltage and the anode voltage at a plurality of specific points, and (d) calculating the voltage difference between the monopole voltage and the anode voltage at a plurality of specific points included in the calculated atrium in a three-dimensional atrium model. Display and execute the step of generating a three-dimensional voltage difference atrial model.

According to the present invention as described above, since the thickness of the left atrium of the heart can be easily and quickly and accurately measured only by a simple input by the user, the high-frequency electrode ceramic ablation procedure also has an effect that an optimal effect can be obtained.

In addition, without additional examination, it is relatively inexpensive, and most patients with arrhythmia measure the thickness of the left atrium of the heart using computed tomography images, which has the effect of minimizing the economic burden of the patient. .

The effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the following description.

1 is a diagram showing an overall configuration included in an apparatus for generating a three-dimensional voltage difference atrial model according to a first embodiment of the present invention.
2 is a flow chart showing representative steps of a method of generating a three-dimensional voltage difference atrial model according to a second embodiment of the present invention.
3 is a diagram showing an exemplary appearance of a catheter.
4 is a flow chart showing specific steps included in step S210.
5(a) is an exemplary view of the voltage of the measurement electrode measured at 2000 ms intervals at a specific point, and FIG. 5(b) is an exemplary view of the voltage of the reference electrode measured at 2000 ms intervals at the same specific point. It is a drawing.
6(a) is an exemplary view of the voltage of the measurement electrode measured at 2000 ms intervals at a specific point different from FIG. 5, and FIG. 6(b) is an exemplary view of the voltage of the reference electrode measured at 2000 ms intervals at the same specific point. It is a drawing showing the appearance.
FIG. 7 is a diagram showing a measured voltage determined by applying the Peak to Peak theory in an exemplary view of the voltage of the measuring electrode shown in FIG. 5A.
8 is a diagram illustrating an exemplary state of a unipolar voltage calculated at any one specific point among a plurality of specific points included in the atrium.
9 is a diagram illustrating an exemplary state of the anode voltage calculated at the same specific point as FIG. 8.
10 is a diagram illustrating a three-dimensional voltage difference atrial model generated by displaying a voltage difference between a unipolar voltage and an anode voltage at a plurality of specific points included in the atrium in a three-dimensional atrial model.
11 is a flowchart illustrating a method for displaying a voltage difference between a unipolar voltage and an anode voltage at all points of a 3D voltage difference atrial model in a method of generating a three-dimensional voltage difference atrial model according to a second embodiment of the present invention. to be.
FIG. 12 is a diagram illustrating a 3D voltage difference atrial model in which voltage differences at all points are displayed by applying a linear interpolation method to the 3D voltage difference atrial model shown in FIG. 10.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. Advantages and features of the present invention, and methods for achieving them will be clarified with reference to embodiments described below in detail together with the accompanying drawings. However, the present invention is not limited to the embodiments to be posted below, but may be implemented in various different forms, and only these embodiments make the posting of the present invention complete, and common knowledge in the technical field to which the present invention pertains. It is provided to fully inform the scope of the invention to those who have it, and the invention is only defined by the scope of the claims. The same reference numerals refer to the same components throughout the specification.

Unless otherwise defined, all terms (including technical and scientific terms) used in the present specification may be used with meanings that can be commonly understood by those of ordinary skill in the art to which the present invention belongs. In addition, terms defined in the commonly used dictionary are not ideally or excessively interpreted unless specifically defined. The terms used in this specification are for describing exemplary embodiments and are not intended to limit the present invention. In the present specification, the singular form also includes the plural form unless otherwise specified in the phrase.

As used herein, "comprises" and/or "comprising" refers to the elements, steps, operations and/or elements mentioned above, the presence of one or more other components, steps, operations and/or elements. Or do not exclude additions.

1 is a diagram showing an overall configuration included in an apparatus 100 for generating a three-dimensional voltage difference atrial model according to a first embodiment of the present invention.

However, this is only a preferred embodiment for achieving the object of the present invention, some components may be added or deleted as necessary, and of course, other components may perform a role played by one component together.

The apparatus 100 for generating a three-dimensional voltage difference atrial model according to the first embodiment of the present invention includes a processor 10, a network interface 20, a memory 30, a storage 40, and a data bus 50 connecting them. It may include.

The processor 10 controls the overall operation of each component. The processor 10 may be any one of a central processing unit (CPU), a micro processor unit (MPU), a micro controller unit (MCU), or a type of processor widely known in the technical field to which the present invention belongs. In addition, the processor 10 may perform an operation on at least one application or program for performing the method of generating a 3D voltage difference atrial model according to the second exemplary embodiment of the present invention.

The network interface 20 supports wired/wireless Internet communication of the apparatus 100 for generating a three-dimensional voltage difference atrial model according to the first embodiment of the present invention, and may support other known communication methods. Therefore, the network interface 20 may include a communication module accordingly.

The memory 30 stores various data, commands, and/or information, and one or more computer programs 41 from the storage 40 to perform the method of generating a three-dimensional voltage difference atrial model according to the second embodiment of the present invention. Can be loaded. Although FIG. 1 shows RAM as one of the memories 30, it is needless to say that various storage media can be used as the memory 30.

The storage 40 may store one or more computer programs 41 and large-capacity network data 42 non-temporarily. The storage 40 is a nonvolatile memory such as a read only memory (ROM), an erasable programmable ROM (EPROM), an electrically erasable programmable ROM (EEPROM), a flash memory, a hard disk, a removable disk, or in the technical field to which the present invention belongs. It may be any one of widely known computer-readable recording media.

The computer program 41 is loaded into the memory 30 and includes a plurality of electrodes by one or more processors 10, and the plurality of electrodes contact a plurality of specific points included in the atrium while being inserted into the heart. Operation of receiving the voltage of the reference electrode and the voltage of the measurement electrode measured by the catheter and calculating the unipolar voltage at a plurality of specific points included in the atrium, a plurality of specific points included in the received atrium The operation of calculating the anode voltage at a plurality of specific points included in the atrium based on the voltage of the measuring electrode measured at, and the voltage difference between the monopole voltage and the anode voltage at a plurality of specific points included in the atrium A three-dimensional atrial model may be generated by displaying an operation of calculating and a voltage difference between a unipolar voltage and an anode voltage at a plurality of specific points included in the calculated atrium on a three-dimensional atrial model.

The operations performed by the computer program 41 simply mentioned so far can be viewed as a function of the computer program 41, and a more detailed description can be found in the method for generating a three-dimensional voltage difference atrial model according to the second embodiment of the present invention. It will be described later in the description of.

Hereinafter, a method of generating a three-dimensional voltage difference atrial model according to a second embodiment of the present invention will be described with reference to FIGS. 2 to 12.

2 is a flow chart showing representative steps of a method of generating a three-dimensional voltage difference atrial model according to a second embodiment of the present invention.

This is only a preferred embodiment in achieving the object of the present invention, some steps may be added or deleted as necessary, and furthermore, one step may be included in another step.

Meanwhile, it is assumed that all steps are performed by the 3D voltage difference atrial model generating apparatus 100 according to the first embodiment of the present invention.

First, it includes a plurality of electrodes, and receives the voltage of the reference electrode and the voltage of the measurement electrode measured by a catheter in which the plurality of electrodes are in contact with a plurality of specific points included in the atrium while being inserted into the heart, The unipolar voltage at a plurality of specific points included in the atrium is calculated (S210).

Here, the catheter includes a plurality of electrodes at the distal end, and is a known medical device capable of measuring and recording the voltage at a point where a plurality of electrodes are brought into contact with the atrium, and an example of a catheter including four electrodes in FIG. 3 Is shown, and the plurality of specific points can be viewed as specific points of the atrium where the plurality of electrodes are in contact.

On the other hand, as will be described later, in the method for generating a three-dimensional voltage difference atrial model according to the second embodiment of the present invention, the step S230 of calculating the voltage difference between the unipolar voltage and the anode voltage should be repeated a predetermined number of times or more. Since it is desirable to rapidly generate a three-dimensional voltage difference atrial model, it is desirable to receive the voltage of the reference electrode and the voltage of the measurement electrode measured by an intubation catheter including 10 electrodes or more.

The apparatus 100 for generating a three-dimensional voltage difference atrial model according to the first embodiment of the present invention receives a voltage of a reference electrode and a voltage of a measurement electrode from such a catheter, and the voltage of a general measurement electrode is among a plurality of electrodes, It means the voltage measured by the other electrodes except the reference electrode, and the voltage of the reference electrode means a voltage measured by contacting one reference electrode at a point separated by a predetermined distance so as not to affect the voltage measurement of the measurement electrode. That is, it can be considered that the voltage of the reference electrode is the same as one with respect to the voltage of the plurality of measurement electrodes.

4 is a flow chart showing the specific steps included in step S210, which is only a preferred embodiment in achieving the object of the present invention, some steps may be added or deleted as necessary, and furthermore, one step may be different Of course, it may be included in the stage.

First, the catheter receives the voltage of the reference electrode and the voltage of the measurement electrode at a plurality of specific points included in the atrium measured at a predetermined time interval of 1 ms to 2000 ms (S210-1).

FIG. 5(a) is an exemplary view of the voltage of the measurement electrode measured at 2000 ms intervals at a specific point, and FIG. 5(b) is an exemplary view of the voltage of the reference electrode measured at 2000 ms intervals at the same specific point. 6(a) shows an exemplary view of the voltage of the measurement electrode measured at 2000 ms intervals at a specific point different from this, and FIG. 6(b) shows an exemplary view of the voltage of the reference electrode measured at 2000 ms intervals at the same specific point. As stated, it can be seen that the voltage of the measuring electrode is different at each specific point, but the voltage of the reference electrode is the same, and the variation of the voltage of the measuring electrode is greater than the variation of the voltage of the reference electrode.

Thereafter, a difference (Peak to Peak) between the highest measured voltage and the lowest measured voltage within a predetermined time interval is determined as the voltage of the measuring electrode (S210-2).

Previously, it was said that the voltage of the general measuring electrode was measured by the other electrodes excluding the reference electrode.More specifically, the voltage of the measuring electrode is Peak Negative, which determines the lowest voltage within a predetermined time interval as the voltage of the measuring electrode. There are a method of determining by applying the theory and a method of determining by applying the Peak to Peak theory, which determines the difference between the highest measured voltage and the lowest measured voltage within a predetermined time interval as the voltage of the measuring electrode. It is preferable to select a method of determining by applying the Peak to Peak theory in order to consider the positional fluctuation due to the heartbeat that may occur between specific points and the fluctuation of the voltage value resulting therefrom, and is shown in Fig.5(a) in Fig.7. In an exemplary view of the voltage of the measured electrode, the measured voltage determined by applying the Peak to Peak theory is shown.

If the voltage of the measurement electrode is determined, the voltage difference between the voltage of the reference electrode and the voltage of the measurement electrode at a plurality of specific points included in the atrium is calculated as a unipolar voltage (S210-3).

Previously, it was said that the voltage of the reference electrode and the voltage of the measurement electrode at a plurality of specific points included in the atrium are received from the catheter at predetermined time intervals, and the unipolar voltage calculated in step S210-3 is the unipolar voltage at a specific time, The single-pole voltage is calculated within a predetermined time interval after the specific time point, and in this case, the single-pole voltage calculated after the specific time point may be different from the single-pole voltage calculated at the specific time point. However, in the following description, for convenience, the description is continued based on the unipolar voltage calculated at a specific point in time, and the description of FIG. 2 is returned again.

If the unipolar voltage is calculated, the anode voltage at a plurality of specific points included in the atrium is calculated based on the voltages of the measurement electrodes measured at a plurality of specific points included in the atrium (S220).

Here, the anode voltage is calculated based on the information on the unipolar voltage calculated in step S210. The measurement electrode determined for the two measurement electrodes is made by using two measurement electrodes separated by a predetermined distance among the plurality of measurement electrodes. The difference in voltage of can be calculated as the anode voltage, and it is preferable to calculate the difference between 1ms and 2000ms, which is a predetermined time interval, by applying the Peak to Peak theory as in the method of calculating the unipolar voltage.

In this case, in calculating the anode voltage, since the reference electrode can be canceled by the difference in voltage between the two measurement electrodes spaced a predetermined distance apart, one of the two measurement electrodes substantially spaced apart a predetermined distance is the reference electrode and the other One can be seen as a measuring electrode.

On the other hand, the two measuring electrodes separated by a predetermined distance may differ according to the catheter specification, but it is preferable to calculate the anode voltage by using two measuring electrodes separated by 2.5 mm as a pair, and accordingly, step S220 includes a catheter. Among the plurality of measurement electrodes, the step of calculating a difference in voltage of the measurement electrodes determined for each of the two electrodes separated by 2.5 mm as the anode voltage (S220-1).

FIG. 8 is a diagram illustrating an exemplary state of a unipolar voltage calculated at a specific point among a plurality of specific points included in the atrium, and FIG. 9 is a diagram illustrating an exemplary state of an anode voltage calculated at the same specific point.

In the case of the unipolar voltage, the reference electrode is in contact with a point separated by a predetermined distance so as not to affect the voltage of the measurement electrode to measure the voltage of the reference electrode. Referring to FIGS. 8 and 9, noise is relatively less than the anode voltage. It is included, but since all of the plurality of measurement electrodes use the same voltage of the same reference electrode, and the voltage of the measurement electrode is independently measured between each measurement electrode, it is possible to specify that each of the plurality of measurement electrodes is in contact with the reference electrode. It can effectively reflect the characteristics of the atrial lining at the location of the point.

In the case of the anode voltage, applying the Peak to Peak theory can cancel the reference electrode used at the unipolar voltage, and the predetermined distance between the two measuring electrodes, 2.5 mm, is the maximum thickness between the atrial inner and outer membranes, which is 2 mm to 3 mm. This is an intermediate value, which effectively reflects the characteristics of the two measuring electrodes in the atrial lining and the thickness of the atrial lining, and the difference in voltage between the measuring electrodes determined in the two measuring electrodes is calculated as the anode voltage. This can be eliminated, has less fluctuation compared to the unipolar voltage, and can effectively reflect the characteristics of the inner and outer atrial membranes.

Accordingly, the present invention using both a unipolar voltage and an anode voltage in generating a three-dimensional voltage difference atrial model can obtain both advantages of using the unipolar voltage and the anode voltage described above.

If the anode voltage is calculated, the voltage difference between the monopole voltage and the anode voltage at a plurality of specific points included in the atrium is calculated (S230).

Here, the plurality of specific points included in the atrium for calculating the voltage difference between the unipolar voltage and the anode voltage refer to a portion in which the position of the measuring electrode from which the unipolar voltage is calculated and the position of the measuring electrode from which the positive voltage is calculated. It follows the following equation.

Equation:

Here, V is the voltage, S is the difference, U is the single pole, B is the anode, and i is the location of a specific point.

If the voltage difference between the unipolar voltage and the anode voltage is calculated, the voltage difference between the unipolar voltage and the anode voltage at a plurality of specific points included in the atrium is displayed in the 3D atrial model to generate a 3D voltage difference atrial model (S240). .

Here, the 3D atrial model may be previously generated and provided through segmentation of a computed tomography image (CT) performed prior to atrial fibrillation electrode catheterectomy, and in addition, a known method for implementing a 3D model of the patient's heart, etc. Of course, it can be provided using. However, the provided 3D atrial model synchronizes the actual position of the patient lying down for atrial fibrillation electrode catheterectomy and the position of data used in a known method for realizing the 3D atrial model. The three-dimensional spatial coordinates should be able to be expressed in a synchronized state on the three-dimensional atrial model.

FIG. 10 exemplarily shows a three-dimensional voltage difference atrial model generated by displaying the voltage difference between the unipolar voltage and the anode voltage at a plurality of specific points included in the atrium in a three-dimensional atrial model, depending on the magnitude of the voltage difference It can be displayed in different colors, and when an input means such as a mouse (not shown) is positioned at a specific point, a 3D voltage difference atrial model may be generated so that the voltage difference at the specific point is output.

So far, representative steps of the method for generating a three-dimensional voltage difference atrial model according to a second embodiment of the present invention have been described. According to the above-described steps S210 to S240, a three-dimensional voltage difference atrial model may be generated in which the voltage difference between the unipolar voltage and the anode voltage is displayed for a plurality of specific points included in the atrium, but the plurality of electrodes included in the catheter are Since the voltage difference between the unipolar voltage and the anode voltage was displayed only for a specific point of contact, it is insufficient to be used in atrial fibrillation electrode catheterectomy. The car needs to be displayed. It will be described below.

11 is a flowchart illustrating a method for displaying a voltage difference between a unipolar voltage and an anode voltage at all points of a 3D voltage difference atrial model in a method of generating a three-dimensional voltage difference atrial model according to a second embodiment of the present invention. to be.

This is only a preferred embodiment in achieving the object of the present invention, some steps may be added or deleted as necessary, and furthermore, one step may be included in another step.

Meanwhile, it is assumed that all steps are performed by the 3D voltage difference atrial model generating apparatus 100 according to the first embodiment of the present invention.

First, after step S240, it is determined whether step S230 is performed a predetermined number of times or more (S250).

Here, the predetermined number of times is the number of times that the voltage difference between the unipolar voltage and the anode voltage can be displayed at all points of the three-dimensional voltage difference atrial model by applying a linear interpolation method to be described later. For example, a catheter includes 10 electrodes. In this case, the predetermined number of times may be 40, and the predetermined number may be different depending on the number of a plurality of electrodes included in the catheter. In this case, if the number of the plurality of electrodes included in the catheter is large, the predetermined number of times will be reduced. Conversely, if the number of the plurality of electrodes included in the catheter is small, the predetermined number will increase.

On the other hand, step S230, which is a criterion for determining whether or not a predetermined number of times has been performed, corresponds to an exemplary determination criterion, and it is possible to determine a predetermined number of times based on step S210 or step S220, and two of steps S210 to S230. A predetermined number of times may be determined based on the above steps.

As a result of the determination in step S250, if it has not been performed more than a predetermined number of times, a plurality of specific points included in the atrium are changed to a plurality of different specific points and return to step S210 (S260).

Here, changing a plurality of specific points included in the atrium to a plurality of different specific points means that the voltage of the reference electrode at the plurality of specific points received from the catheter in step S210 and the reference electrode at a plurality of specific points different from the voltage of the measurement electrode In order to receive the voltage of the measuring electrode and the voltage of the catheter, the specific point of contact with the catheter must be intentionally changed. More specifically, a doctor or user who performs atrial fibrillation electrode catheterectomy changes and contacts electrodes in contact with a plurality of specific points to other specific points.If the catheter is an intubation catheter, the electrode is inserted into the atrium. The change of the contact point of can be easily performed.

In this case, if a plurality of specific points included in the atrium are changed to a plurality of specific points different from the specific points and return to step S210, steps S220 to S230 performed later will be performed based on the changed plurality of specific points, and step S240 In the three-dimensional voltage difference atrial model in which the voltage difference between the unipolar voltage and the anode voltage for a plurality of previously generated specific points is displayed, the voltage difference between the unipolar voltage and the anode voltage for the changed specific points may be additionally displayed. For example, in the first S240 step performed, 9 specific points (1, 2, 3), (4, 5, 6), (7, 8, 9), (10, 11, 12), (13, 14, 15), (16, 17, 18), (19, 20, 21), (22, 23, 24), (25, 26, 27) if the voltage difference between the unipolar voltage and the anode voltage is displayed, the changed 9 The four specific points are (2, 3, 4), (5, 6, 7), (8, 9, 10), (11, 12, 13), (14, 15, 16), (17, 18, 19) ), (20, 21, 22), (23, 24, 25), (26, 27, 28), and the voltage difference between the unipolar voltage and the anode voltage may be additionally displayed at the corresponding point.

Meanwhile, a separate counting step (S265) may be further included before or after step S260 to determine whether or not more than a predetermined number of times have been performed. If it is determined that the number of times is not performed more than a predetermined number in step S250, the number of counting is increased by 1. It will be able to contribute to making an accurate judgment.

As a result of the determination of step S250, if it is performed more than a predetermined number of times, linear interpolation is applied to the voltage difference between the monopole voltage and the anode voltage at a plurality of specific points displayed in the generated 3D voltage difference atrial model. The voltage difference is displayed at the point (S270).

Here, the linear interpolation method can be applied according to the following equation.

Equation:

Here, R is the threshold distance, and d is the distance between the point where the voltage difference is to be displayed and a plurality of specific points.

Accordingly, the above equation can be regarded as calculating and averaging all linear relationships between a point to display the voltage difference and a distance between a plurality of specific points and a limited threshold distance, and the threshold distance R is from the point at which the voltage difference is to be displayed. It is an item for excluding the voltage difference displayed at a point that is too far apart, for example, it may be 16 mm, and may be different according to the catheter standard.

FIG. 12 exemplarily shows a 3D voltage difference atrial model in which voltage differences at all points are displayed by applying a linear interpolation method to the 3D voltage difference atrial model shown in FIG. 10. It is possible to display different colors according to the size of, and when an input means such as a mouse (not shown) is placed at a specific point, a three-dimensional voltage difference atrial model may be generated so that the voltage difference at the specific point is output.

So far, all the steps included in the method for generating a three-dimensional voltage difference atrial model according to the second embodiment of the present invention have been described. According to the present invention, a three-dimensional voltage difference atrial model capable of estimating the thickness of the heart prior to atrial fibrillation electrode catheterectomy can be quickly and simply generated by using a catheter. In this case, a doctor or user performing atrial fibrillation electrode catheterectomy can easily adjust the high frequency energy intensity of atrial fibrillation electrode catheterectomy for each atrial region while checking the three-dimensional voltage difference atrial model in real time.

Meanwhile, the method for generating a three-dimensional voltage difference atrial model according to another embodiment of the present invention may be implemented as a computer program stored in a storage medium for execution in a computer.

Although not described in detail in order to prevent redundant description, the computer program stored in the storage medium may also perform the same steps as the 3D voltage difference atrial model generation apparatus according to another embodiment of the present invention described above, and accordingly You can derive the effect. For example, a computer program stored in a medium includes a plurality of electrodes in combination with a computing device, and a catheter in which the plurality of electrodes are in contact with a plurality of specific points included in the atrium when inserted into the heart Receiving the measured voltage of the reference electrode and the voltage of the measurement electrode, and calculating a unipolar voltage at a plurality of specific points included in the atrium, the measurement electrode measured at a plurality of specific points included in the received atrium Based on the voltage, calculating an anode voltage at a plurality of specific points included in the atrium, calculating a voltage difference between a unipolar voltage and an anode voltage at a plurality of specific points included in the calculated atrium, and the The step of generating a three-dimensional voltage difference atrial model may be executed by displaying the voltage difference between the unipolar voltage and the anode voltage at a plurality of specific points included in the calculated atrium on a three-dimensional atrial model.

Although the embodiments of the present invention have been described with reference to the accompanying drawings, a person skilled in the art to which the present invention pertains may be implemented in other specific forms without changing the technical concept or essential features of the present invention. You will understand. Therefore, it should be understood that the embodiments described above are illustrative and non-limiting in all respects.

10: processor
20: network interface
30: memory
40: storage
41: computer program
50: data bus
100: 3D voltage difference atrial model generation device

Claims (12)

In a method for generating a three-dimensional voltage-difference atrial model for determining a high frequency energy intensity of atrial fibrillation electrode catheterctomy by an apparatus for generating a three-dimensional voltage difference atrial model for atrial fibrillation electrode catheterectomy,
(a) It includes a plurality of electrodes, and receives the voltage of the reference electrode and the voltage of the measurement electrode measured by a catheter in which the plurality of electrodes are in contact with a plurality of specific points included in the atrium while being inserted into the heart. Thus, calculating a unipolar voltage at a plurality of specific points included in the atrium;
(b) calculating anode voltages at a plurality of specific points included in the atrium based on voltages of measurement electrodes measured at a plurality of specific points included in the received atrium;
(c) calculating a voltage difference between a single pole voltage and a positive pole voltage at a plurality of specific points included in the measured atrium; And
(d) generating a three-dimensional voltage difference atrial model by displaying the voltage difference between the unipolar voltage and the anode voltage at a plurality of specific points included in the calculated atrium on a three-dimensional atrial model;
A three-dimensional voltage difference atrial model generation method comprising a. The method of claim 1,
The catheter,
Including 10 electrodes,
3D voltage difference atrial model generation method. The method of claim 1,
The step (a),
(a-1) receiving a voltage of a reference electrode and a voltage of a measurement electrode at a plurality of specific points included in the atrium, measured at intervals of 1 ms to 2000 ms by the catheter;
A three-dimensional voltage difference atrial model generation method comprising a. The method of claim 3,
The step (a),
(a-2) determining a peak to peak difference between the highest measured voltage and the lowest measured voltage as the voltage of the measuring electrode within the predetermined time interval;
A three-dimensional voltage difference atrial model generation method comprising a. The method of claim 4,
The step (b),
(b-1) calculating a difference in voltage of the determined measuring electrode for each of the two electrodes separated by 2.5 mm from among the plurality of electrodes included in the catheter as the anode voltage;
A three-dimensional voltage difference atrial model generation method comprising a. The method of claim 1,
The step (a),
(a-3) calculating a voltage difference between a voltage of a reference electrode and a voltage of a measurement electrode at a plurality of specific points included in the received atrium as the single-pole voltage;
A three-dimensional voltage difference atrial model generation method comprising a. The method of claim 1,
The reference electrode,
Measuring the voltage of the reference electrode by contacting a point separated by a predetermined distance so as not to affect the voltage measurement of the measuring electrode,
3D voltage difference atrial model generation method. The method of claim 1,
After step (d),
(e) determining whether the step (c) has been performed more than a predetermined number of times;
A three-dimensional voltage difference atrial model generation method further comprising. The method of claim 8,
As a result of the determination in step (e), if it has not been performed more than a predetermined number of times,
(f) changing a plurality of specific points included in the atrium to a plurality of different specific points and returning to the step (a);
A three-dimensional voltage difference atrial model generation method further comprising. The method of claim 8,
As a result of the determination in step (e), if it is performed more than a predetermined number of times,
(g) Applying a linear interpolation method to the voltage difference between the monopole voltage and the anode voltage at a plurality of specific points displayed in the generated three-dimensional voltage difference atrial model, to display the voltage difference at all points of the three-dimensional voltage difference atrial model. step;
A three-dimensional voltage difference atrial model generation method further comprising. One or more processors;
Network interface;
A memory for loading a computer program executed by the processor; And
Including storage for storing large-capacity network data and the computer program,
The computer program,
(a) It includes a plurality of electrodes, and receives the voltage of the reference electrode and the voltage of the measurement electrode measured by a catheter in which the plurality of electrodes are in contact with a plurality of specific points included in the atrium while being inserted into the heart. Thus, an operation of calculating a unipolar voltage at a plurality of specific points included in the atrium;
(b) an operation of calculating anode voltages at a plurality of specific points included in the atrium based on voltages of measurement electrodes measured at a plurality of specific points included in the received atrium;
(c) an operation of calculating a voltage difference between a single pole voltage and a positive pole voltage at a plurality of specific points included in the calculated atrium; And
(d) an operation of generating a three-dimensional voltage difference atrial model by displaying the voltage difference between the unipolar voltage and the anode voltage at a plurality of specific points included in the calculated atrium on a three-dimensional atrial model;
A three-dimensional voltage difference atrial model generating apparatus comprising a. Combined with a computing device,
(a) It includes a plurality of electrodes, and receives the voltage of the reference electrode and the voltage of the measurement electrode measured by a catheter in which the plurality of electrodes are in contact with a plurality of specific points included in the atrium while being inserted into the heart. Thus, calculating a unipolar voltage at a plurality of specific points included in the atrium;
(b) calculating anode voltages at a plurality of specific points included in the atrium based on voltages of measurement electrodes measured at a plurality of specific points included in the received atrium;
(c) calculating a voltage difference between a single pole voltage and a positive pole voltage at a plurality of specific points included in the calculated atrium; And
(d) generating a three-dimensional voltage difference atrial model by displaying the voltage difference between the unipolar voltage and the anode voltage at a plurality of specific points included in the calculated atrium on a three-dimensional atrial model;
To implement,
A computer program stored on a medium.

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