KR20200070890A - Composition for the screening of wound healing agent and screening method for the same - Google Patents

Composition for the screening of wound healing agent and screening method for the same Download PDF

Info

Publication number
KR20200070890A
KR20200070890A KR1020180158538A KR20180158538A KR20200070890A KR 20200070890 A KR20200070890 A KR 20200070890A KR 1020180158538 A KR1020180158538 A KR 1020180158538A KR 20180158538 A KR20180158538 A KR 20180158538A KR 20200070890 A KR20200070890 A KR 20200070890A
Authority
KR
South Korea
Prior art keywords
dna
seq
artificial sequence
wound
screening
Prior art date
Application number
KR1020180158538A
Other languages
Korean (ko)
Other versions
KR102195319B1 (en
Inventor
김태성
이병철
조대호
Original Assignee
고려대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 고려대학교 산학협력단 filed Critical 고려대학교 산학협력단
Priority to KR1020180158538A priority Critical patent/KR102195319B1/en
Publication of KR20200070890A publication Critical patent/KR20200070890A/en
Application granted granted Critical
Publication of KR102195319B1 publication Critical patent/KR102195319B1/en

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

The present invention relates to a composition for screening for a wound-healing agent, and a screening method for a wound-healing agent using the same. The present inventors have investigated to identify exact mechanisms of natural healing processes and the genes involved therein, have analyzed, using cDNA microarray, fibroblasts expressed due to stimulation of epithelial growth factor (EGF) used as a wound-healing material and have procured a list of genes, and have analyzed the genes included in existing kits and subsequently built a list of 92 new genes. By using a complementary primer set using the list of genes or the like, wound-healing agent screening kits and the like may be manufactured and utilized. In addition, by using such kits, wound-healing candidate materials can be rapidly investigated and evaluated from a number of preparations derived from natural products or artificially synthesized small molecules or peptides in an inexpensive and less time-consuming manner, thereby enabling an efficient development of wound-healing agents. Further, the present invention is expected to be utilized in clinical trials for prognostic assessment of chronic wound or acute wound treatment.

Description

상처치료제 스크리닝용 조성물 및 이를 이용한 상처 치료제 스크리닝 방법{Composition for the screening of wound healing agent and screening method for the same}Composition for the screening of wound healing agents and a method for screening wound healing using the same{Composition for the screening of wound healing agent and screening method for the same}

본 발명은 상처 치료제 스크리닝용 조성물 및 이를 이용한 상처 치료제 스크리닝 방법에 관한 것으로서, 보다 구체적으로는 상처 치료 관련 유전자에 상보적인 프라이머 등 또는 상처 치료 관련 단백질에 특이적으로 결합하는 항체 등을 포함하는 상처 치료제 스크리닝용 조성물, 이를 포함하는 키트, 이를 이용한 상처 치료제 스크리닝 방법 및 상처 치료 관련 단백질을 유효성분으로 포함하는 상처 치료용 약학적 조성물에 관한 것이다.The present invention relates to a composition for screening a wound treatment and a method for screening a wound treatment using the same, and more specifically, a wound treatment comprising a primer complementary to a gene related to wound treatment or an antibody specifically binding to a protein related to wound treatment. It relates to a composition for screening, a kit comprising the same, a method for screening a wound treatment using the same, and a pharmaceutical composition for treating a wound comprising a wound-related protein as an active ingredient.

피부는 전체 인체 질량의 15~20%를 차지하는 조직임과 동시에 일차 방어막으로서 온도와 습도의 변화, 자외선, 오염 물질 등 외부환경에 의한 자극으로부터 보호해 주며, 인체 항상성 유지에 중요한 역할을 한다. 피부는 표피층(epidermis), 진피층(dermis), 피하지방층(subcutaneous fat tissue) 세 층으로 나눌 수 있다. The skin is a tissue that accounts for 15-20% of the total human body mass, and as a primary barrier, it protects against changes in temperature and humidity, irritation caused by external environments such as ultraviolet rays and pollutants, and plays an important role in maintaining human homeostasis. The skin can be divided into three layers: epidermis, dermis, and subcutaneous fat tissue.

표피는 피부의 가장 외측에 존재하며 비교적 방수성이 있고 대부분의 세포는 각질 형성세포들로 표피의 가장 깊은 층에 있는 기저층에 위치한 세포에서 시작하여 표피층으로 올라가면서 세포의 생명력이 없어지며, 견고하고 규칙적인 세포층으로 변하게 되고 피부 표면에 도달하면 떨어져 나가게 된다. 표피는 내부 조직 및 장기를 각종 외상으로부터 보호하며, 물리적 및 면역학적 측면에서 많은 병원균등 외부 물질이 신체에 침투하는 것을 방어하는 역할을 한다. 피부의 표면에 상처가 생길 경우, 표피의 빠른 재생 능력으로 인한 상처의 회복을 촉진하여 추가 감염을 방지하는 역할을 한다. 진피는 피부를 유지하는 조직으로 신경말단, 땀샘, 피지선을 포함한 각 종 분비선 및 혈관 등의 다양한 기관이 있다. 피부의 섬유아세포 (fibroblast)에서 생성되는 주요 기질 단백질 중 콜라겐은 생체 단백질 총 중량의 약 30%를 차지하며 피부의 진피에 대부분이 존재한다. 그러므로 콜라겐은 상처 치료에서 중요한 역할을 담당한다고 할 수 있다. The epidermis is located on the outermost side of the skin, is relatively waterproof, and most of the cells are keratinocytes, starting from the cells located in the basement layer at the deepest layer of the epidermis and going up to the epidermal layer, where the cell's vitality is lost, firm and regular It turns into a layer of red cells and falls off when it reaches the skin surface. The epidermis protects internal tissues and organs from various traumas and, in terms of physical and immunological aspects, serves to protect foreign substances such as many pathogens from penetrating the body. When a wound is formed on the surface of the skin, it promotes the recovery of the wound due to the rapid regeneration ability of the epidermis, thereby preventing further infection. The dermis is a tissue that maintains the skin, and there are various organs such as nerve glands, sweat glands, sebaceous glands, and various glands and blood vessels. Of the major matrix proteins produced in the skin's fibroblasts, collagen accounts for about 30% of the total weight of bio-proteins and is mostly present in the dermis of the skin. Therefore, it can be said that collagen plays an important role in wound healing.

상처받은 피부 조직은 자연적인 일련의 치유과정으로 각종 세포와 인자가 관여하여 매우 복잡한 반응이다. 상처 치유 과정은 크게 염증단계, 상피화단계, 증식단계, 성숙단계의 4단계로 나뉘며, 이들 단계는 중첩되어 연속적으로 진행된다. 이는 각 과정에서 나타나는 세포들과 이들 세포에서 분비되는 각종 세포 증식인자가 혈관내피, 탐색세포, 섬유아세포, 상피세포 등에 자극을 주어 세포 증식을 유도하며, 이들 세포는 자체적으로 분비하는 섬유아세포 증식, 형질전환 증식인자, 인터류킨 등의 물질을 생산하여 상처치유가 된다. Wounded skin tissue is a natural series of healing processes, involving a variety of cells and factors, making it a very complex reaction. The wound healing process is largely divided into four stages: an inflammatory stage, an epithelialization stage, a proliferation stage, and a maturation stage, and these stages overlap and progress continuously. This induces cell proliferation by stimulating vascular endothelial cells, probing cells, fibroblasts, epithelial cells, etc., which appear in each process and various cell proliferation factors secreted from these cells, and these cells secrete fibroblast proliferation, Transformation proliferation factor, interleukin, and other substances are produced to heal wounds.

그러나, 다양한 상처 치료 제제를 개발 과정에 많은 경제적, 시간적으로 소비가 되는 상태이고, 기존의 상처 치유 관련 유전자를 이용한 실시간 유전자 중합반응 키트를 판매하고 있지만, 이는 단지 기존에 보고되었던 상처 치유 관련 유전자를 나열하는 식에 불과한 실정이었다. 즉, 자연 치유 과정의 정확한 기전과 관련한 유전자들을 알아내기 위한 연구 및 개발이 부족한 실정이었다.However, a variety of wound healing preparations are in a state of being economically and time consuming in the development process, and real-time gene polymerization kits using existing wound healing-related genes are being sold, but these are only wound healing-related genes previously reported. It was just a matter of listing. In other words, there was a lack of research and development to find genes related to the exact mechanism of the natural healing process.

대한민국 등록특허공보 10-1796141Republic of Korea Registered Patent Publication 10-1796141

본 발명은 ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, ENO1, ERRFI1, ESM1,FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3,IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5,ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, VISFATIN, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2,TGFB1, TGFBR3, TIMP1, TMEM158, TNFAIP6, VEGFA, WNT5A, 및 GAPDH(이하, 92개의 유전자들)로 이루어진 군으로부터 선택되는 하나 이상의 유전자에 상보적인 프라이머(primer) 세트 또는 프로브 세트를 포함하는, 상처 치료제 스크리닝용 조성물을 제공하는 것을 목적으로 한다.The present invention is ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR1, EGR1, EGR1 ,FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3,IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL -8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5,ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, VISFATIN, NPAS2, PDGFA, PLAT, PLAU , PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2,TGFB1, TGFBR3, TIMP1, TMEM158, TNF158 And a primer set or probe set complementary to one or more genes selected from the group consisting of GAPDH (hereinafter, 92 genes).

또한,본 발명은 ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, ENO1, ERRFI1, ESM1,FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3,IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5,ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, VISFATIN, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2,TGFB1, TGFBR3, TIMP1, TMEM158, TNFAIP6, VEGFA, WNT5A, 및 GAPDH의 유전자로부터 코딩되는 단백질(이하, 92개의 단백질들)로 이루어진 군으로부터 선택되는 하나 이상의 단백질에 특이적으로 결합하는 항체, 압타머, 또는 리간드를 포함하는, 상처 치료제 스크리닝용 조성물을 제공하는 것을 목적으로 한다.In addition, the present invention ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR1, EGR1, EGR1 , ESM1,FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3,IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R , IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5,ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, VISFATIN, NPAS2, PDGFA, PLAT , PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2,TGFB1, TGFBR3, TIMP1, TMEM , WNT5A, and an antibody, aptamer, or ligand that specifically binds to one or more proteins selected from the group consisting of proteins (hereinafter, 92 proteins) encoded from the genes of GAPDH, wound treatment screening composition It aims to provide.

또한, 본 발명은 상기 조성물을 포함하는 상처 치료제 스크리닝용 키트를 제공하는 것을 목적으로 한다.In addition, an object of the present invention is to provide a kit for screening a wound treatment comprising the composition.

또한, 본 발명은 (a) 섬유아세포에 분석하고자 하는 시료를 처리하는 단계;(b) 상기 섬유아세포에서 상기 92개의 유전자들로 이루어진 군으로부터 선택되는 하나 이상의 유전자 발현량을 측정하는 단계; 및 (c) 상기 시료의 처리로 (b)단계에서 유전자 발현량이 증가하는 경우 상처치료제로 선별하는 단계를 포함하는, 상처 치료제를 스크리닝하는 방법을 제공하는 것을 목적으로 한다.In addition, the present invention (a) processing a sample to be analyzed for fibroblasts; (b) measuring the expression level of one or more genes selected from the group consisting of the 92 genes in the fibroblasts; And (c) screening with a wound treatment agent when the gene expression level in step (b) increases due to the treatment of the sample, to provide a method for screening a wound treatment agent.

또한, 본 발명은 상기 92개 단백질들로 이루어진 군으로부터 선택되는 하나 이상의 단백질을 유효성분으로 포함하는 상처 치료용 약학적 조성물을 제공하는 것을 목적으로 한다.In addition, an object of the present invention is to provide a pharmaceutical composition for treating wounds comprising at least one protein selected from the group consisting of 92 proteins as an active ingredient.

그러나, 본 발명이 이루고자 하는 기술적 과제는 이상에서 언급한 과제에 제한되지 않으며, 언급되지 않은 또 다른 과제들은 아래의 기재로부터 본 발명이 속하는 기술 분야의 통상의 지식을 가진 자에게 명확하게 이해될 수 있을 것이다.However, the technical problem to be achieved by the present invention is not limited to the above-mentioned problems, and other problems not mentioned can be clearly understood by those skilled in the art from the following description. There will be.

상기와 같은 본 발명의 목적을 달성하기 위하여,In order to achieve the object of the present invention as described above,

본 발명은 상기 92개의 유전자들로 이루어진 군으로부터 선택되는 하나 이상의 유전자에 상보적인 프라이머(primer) 세트 또는 프로브 세트를 포함하는, 상처 치료제 스크리닝용 조성물을 제공한다.The present invention provides a composition for screening a wound treatment, comprising a primer set or a probe set complementary to one or more genes selected from the group consisting of the 92 genes.

본 발명의 일 구현 예로, 상기 프로브 세트는 형광 표지 물질을 갖는 표지 프로브 세트일 수 있다.In one embodiment of the present invention, the probe set may be a set of labeled probes having a fluorescent labeling material.

또한, 본 발명은 상기 92개의 단백질들로 이루어진 군으로부터 선택되는 하나 이상의 단백질에 특이적으로 결합하는 항체, 압타머, 또는 리간드를 포함하는 상처 치료제 스크리닝용 조성물을 제공한다.In addition, the present invention provides a composition for screening a wound treatment comprising an antibody, an aptamer, or a ligand specifically binding to one or more proteins selected from the group consisting of the 92 proteins.

또한, 본 발명은 상기 조성물을 포함하는 상처 치료제 스크리닝용 키트를 제공한다.In addition, the present invention provides a kit for screening a wound treatment comprising the composition.

또한, 본 발명은 (a) 섬유아세포에 분석하고자 하는 시료를 처리하는 단계; (b) 상기 섬유아세포에서 상기 92개 유전자들로 이루어진 군으로부터 선택되는 하나 이상의 유전자 발현량을 측정하는 단계; 및 (c)상기 시료의 처리로 (b)단계에서 유전자 발현량이 증가하는 경우 상처치료제로 선별하는 단계를 포함하는, 상처 치료제를 스크리닝하는 방법을 제공한다.In addition, the present invention (a) processing a sample to be analyzed for fibroblasts; (b) measuring one or more gene expression levels selected from the group consisting of the 92 genes in the fibroblasts; And (c) provides a method for screening a wound treatment, comprising the step of screening with a wound treatment agent when the gene expression in step (b) increases with the treatment of the sample.

또한, 본 발명은 상기 92개의 단백질들로 이루어진 군으로부터 선택되는 하나 이상의 단백질을 유효성분으로 포함하는 상처 치료용 약학적 조성물을 제공한다.In addition, the present invention provides a pharmaceutical composition for wound treatment comprising at least one protein selected from the group consisting of 92 proteins as an active ingredient.

본 발명의 일 구현 예로, 상기 단백질은 VISFATIN 또는 STC1 단백질일 수 있다.In one embodiment of the invention, the protein may be a VISFATIN or STC1 protein.

본 발명의 또 다른 구현 예로, 상기 상처 치료용 약학적 조성물은ERK(extracelluar signal-regulated kinases) 및 JNK(c-jun N-termial kinases)의 활성화를 유도해서 혈관내피성장인자(Vascular endothelial growth factor; VEGF)의 발현을 증가시킬 수 있다.In another embodiment of the present invention, the pharmaceutical composition for the treatment of wounds induces activation of extracelluar signal-regulated kinases (ERK) and c-jun N-termial kinases (JNK) to induce activation of Vascular endothelial growth factor; VEGF).

또한, 본 발명은 상기 92개의 단백질들로 이루어진 군으로부터 선택되는 하나 이상의 단백질을 유효성분으로 포함하는 약학적 조성물을 개체에 투여하는 단계를 포함하는, 상처 예방 또는 치료방법을 제공한다.In addition, the present invention provides a method for preventing or treating wounds, comprising administering to a subject a pharmaceutical composition comprising at least one protein selected from the group consisting of 92 proteins as an active ingredient.

또한, 본 발명은 상기 92개의 단백질들로 이루어진 군으로부터 선택되는 하나 이상의 단백질을 유효성분으로 포함하는 약학적 조성물의 상처 예방 또는 치료용도를 제공한다.In addition, the present invention provides a wound composition for the prevention or treatment of a pharmaceutical composition comprising at least one protein selected from the group consisting of the 92 proteins as an active ingredient.

본 발명자들은 자연 치유 과정의 정확한 기전과 관련한 유전자들을 알아내기 위해 예의 연구한 결과, 상처 치유 물질로 사용되는 표피세포 증식인자(EGF; epithelial growth factor) 자극에 의해 발현된 섬유아세포를 cDNA microarray를 통해 분석한 뒤 유전자 목록을 확보하고, 기존의 키트에 포함된 유전자들을 분석한 다음 새로운 92개의 유전자 목록을 구축하였는 바, 상기 유전자 목록을 이용한 상보적인 프라이머 세트 등을 통하여 상처 치료제 스크리닝용 키트 등을 제작 활용할 수 있다. 또한, 수많은 천연물에서 유래한 제제나 인위적으로 합성된 작은 분자나 펩타이드로부터 상처치료 후보 물질을 상기 키트 등을 통하여 신속하게 탐색하고 평가할 수 있는 바 경제적이고 시간적 소비를 줄여, 효율적으로 상처 치료제를 개발할 수 있을 것으로 예상되고, 임상에서 만성 창상이나 급성 창상의 치료 예후 평가에도 활용될 수 있을 것으로 기대되며, 발굴된 92개의 유전자의 실질적인 상처치유 효과를 조사하여 새로운 상처치료제로서의 역할을 밝혀낼 수 있는 바, 상처치료제 시장에 유용할 것으로 기대된다.The present inventors conducted extensive studies to find genes related to the precise mechanism of the natural healing process. As a result, fibroblasts expressed by stimulation of epithelial growth factor (EGF) used as a wound healing material through cDNA microarray. After analysis, the gene list was obtained, the genes included in the existing kits were analyzed, and 92 new gene lists were constructed. Thus, a kit for wound treatment screening, etc. was produced through a complementary primer set using the gene list. Can be utilized. In addition, it is possible to quickly search for and evaluate wound healing candidate substances from preparations derived from a number of natural products or artificially synthesized small molecules or peptides through the kit and the like, thereby reducing economical and time consuming and efficiently developing wound healing agents. It is expected to be used in clinical and clinical prognosis evaluation of chronic wounds or acute wounds, and the actual wound healing effect of the 92 genes discovered can be investigated to reveal its role as a new wound healing agent. It is expected to be useful in the wound treatment market.

도 1은 cDNA microarray를 이용하여 발굴한 상처치료에 관련된 92개의 유전자를 표로 나타낸 것이다.
도 2a 및 2b는 도 1에서 발굴한 92개 유전자 중 2개의 유전자로부터 발현된 VISFATIN 단백질(도 2a)과 STC1 단백질(도 2b)의 세포증식 효과를 BrdU 어세이를 통해 확인한 결과를 그래프로 나타낸 것이다.
도 3a 및 3b는 상기 VISFATIN 단백질(도 3a)과 STC1 단백질(도 3b)의 세포 이동능력 증가를 확인하기 위하여, 스크래치 어세이를 통해 확인한 결과를 염색된 세포 이미지 및 그래프로 나타낸 것이다.
도 4a 및 4b는 상기 VISFATIN 단백질(도 4a) 과 STC1 단백질(도 4b)이 상처 치유 능력을 향상시키는 지를 확인하기 위하여, 마우스 동물 급성창상 모델에서 창상의 치유변화를 이미지 및 그래프로 나타낸 것이다.
도 5는 마우스 급성창상 모델에서 상처 치유를 향상시키는 원인을 확인하기 위하여, 헤마톡실린&에오신(H&E) 조직염색을 통해 epithelial tongue의 증가를 이미지 및 그래프로 나타낸 것이다. 또한, 조직 내 혈관내피성장인자인 VEGF의 발현을 측정한 결과를 VEGF 항체를 이용한 조직형광염색 이미지 및 그래프로 나타낸 것이다.
도 6은 VEGF의 발현증가와 관련된 분자적 메커니즘을 확인하기 위하여, ERK 및 JNK의 발현을 측정한 결과를 각각 인산화-ERK와 인산화-JNK 항체를 이용한 조직형광염색 이미지 및 그래프로 나타낸 것이다.1 is a table showing 92 genes related to wound healing excavated using cDNA microarray.
2A and 2B are graphs showing the results of confirming the cell proliferation effect of VISFATIN protein (FIG. 2A) and STC1 protein (FIG. 2B) expressed from 2 genes among 92 genes excavated in FIG. 1 through BrdU assay. .
3A and 3B show stained cell images and graphs of the results confirmed through the scratch assay in order to confirm an increase in cell migration capacity of the VISFATIN protein (FIG. 3A) and STC1 protein (FIG. 3B).
4A and 4B are images and graphs of healing changes of wounds in acute wound models of mouse animals to confirm whether the VISFATIN proteins (FIG. 4A) and STC1 proteins (FIG. 4B) enhance wound healing ability.
FIG. 5 is an image and graph showing an increase in epithelial tongue through hematoxylin & eosin (H&E) tissue staining in order to identify a cause of improving wound healing in a mouse acute wound model. In addition, the results of measuring the expression of VEGF, a vascular endothelial growth factor in tissues, are shown in tissue fluorescence staining images and graphs using VEGF antibodies.
6 is a graph showing tissue fluorescence staining images and graphs using phosphorylation-ERK and phosphorylation-JNK antibodies, respectively, in order to confirm the molecular mechanism associated with increased expression of VEGF.

본 발명자들은 자연 치유 과정의 정확한 기전과 관련한 유전자들을 알아내기 위해 예의 연구한 결과, 상처 치유 물질로 사용되는 표피세포 증식인자(EGF; epithelial growth factor) 자극에 의해 발현된 섬유아세포를 cDNA microarray를 통해 분석한 뒤 유전자 목록을 확보하고, 기존의 키트에 포함된 유전자들을 분석한 다음 새로운 92개의 유전자 목록을 구축하였는 바, 상기 유전자 목록을 이용한 상보적인 프라이머 세트 등을 통하여 상처 치료제 스크리닝용 키트 등을 제작 활용하여, 상처치료 후보 물질을 신속하게 탐색할 수 있고, 이와 동시에 상처치료 후보 물질이 영향을 미치는 유전자 타겟을 확보할 수 있다는 것을 확인하고 본 발명을 완성하였다.The present inventors conducted extensive studies to find genes related to the precise mechanism of the natural healing process. As a result, fibroblasts expressed by stimulation of epithelial growth factor (EGF) used as a wound healing material through cDNA microarray. After analysis, the gene list was obtained, the genes included in the existing kits were analyzed, and 92 new gene lists were constructed. Thus, a kit for wound treatment screening, etc. was produced through a complementary primer set using the gene list. By utilizing this, it was confirmed that the candidate material for wound healing can be quickly searched, and at the same time, the gene target affecting the candidate material for wound treatment can be secured and the present invention has been completed.

이하, 본 발명을 자세히 설명한다.Hereinafter, the present invention will be described in detail.

본 발명은 ACTA2(alpha-action-2), BMPER(BMP binding endothelial regulator), CCL2(chemokine ligand 2), CH25H(cholesterol 25-hydroxylase), COL1A1(collagen type I alpha 1 chain), COL1A2(collagen type I alpha 2 chain), COL3A1(collagen type III alpha 1 chain), COL4A1(collagen type IV alpha 1 chain), COL5A1(collagen type V alpha 1 chain), COL5A2(collagen type V alpha 2 chain), CSF3(colony-stimulating factor 3), CTGF(connective tissue growth factor), CTNNB1, CTSK(catherpsin K), CXCL1(c-x-c motif chemokine ligand 1), CXCL5(c-x-c motif chemokine ligand 5), CXCL6(c-x-c motif chemokine ligand 6), DUSP6(dual specificity phosphatase 6), EGFR(epidermal growth factor receptor), EGR1(early growth response 1), EMP1(epithelial membrane protein 1), ENO1(enolase 1), ERRFI1(ERBB receptor feedback inhibitor 1), ESM1(endothelial cell specific molecule 1), FGA(fibrinogen alpha chain), FGF2(fibroblast growth factor 2), FGF7(fibroblast growth factor 7), FGF10(fibroblast growth factor 10), FOSL1(FOS like 1, AP-1 transcription factor subunit), FST(follistatin), HAS2(hyaluronan synthase 2), HBEGF(heparin binding EGF like growth factor), HGF(hepatocyte growth factor), HMGA2(high mobility group AT-hook 2), ICAM1(intercellular adhesion molecule 1), IER3(immediate early response 3), IL-13RA2(interleukin 13 receptor, alpha 2), IL-33(interleukin 33), IL-1B(interleukin 1 beta), IL-6(interleukin 6), IL-6ST(interleukin 6 signal transducer), IL-7R(interleukin 7 receptor), IL-8(interleukin 8), ITGA1(integrin subunit alpha 1), ITGA2(integrin subunit alpha 2), ITGA3(integrin subunit alpha 3), ITGA4(integrin subunit alpha 4), ITGA5(integrin subunit alpha 5), ITGAV(integrin subunit alpha V), ITGB1(integrin subunit beta 1), ITGB3(integrin subunit beta 3), ITGB5(integrin subunit beta 5), KRTAP1-5(keratin associated protein 1-5), LPXN(leupaxin), MAPK1(mitogen-activated protein kinase 1), MAPK3(mitogen-activated protein kinase 3), MCL1(MCL1, BCL2 family apoptosis regulator), MIF(macrophage migration inhibitory factor), MMP1(matrix metallopeptidase 1), MMP2(matrix metallopeptidase 2), MMP3(matrix metallopeptidase 3), VISFATIN(NAMPT;nicotinamide phosphoribosyltransferase), NPAS2(neuronal PAS domain protein 2), PDGFA(platelet derived growth factor subunit A), PLAT(plasminogen activator, tissue type), PLAU(plasminogen activator, urokinase), PLAUR(plasminogen activator, urokinase receptor), PLG(plasminogen), PTEN(phosphatase and tensin homolog), PTGS2(prostaglandin-endoperoxide synthase 2), PTX3(pentraxin 3), RAC1(Rac family small GTPase 1), RHOA(ras homolog family member A), SERPINB2(serpin family B member 2), SERPINE1(serpin family E member 1), SERPINE2(serpin family E member 2), SLC20A1(solute carrier family 20 member 1), SLIT2(slit guidance ligand 2), SMURF2(SMAD specific E3 ubiquitin protein ligase 2), STAT3(signal transducer and activator of transcription 3), STC1(stanniocalcin 1), SDC4(syndecan 4), TAGLN(transgelin), TFPI2(tissue factor pathway inhibitor 2),TGFB1(transforming growth factor beta 1), TGFBR3(transforming growth factor beta receptor 3), TIMP1(TIMP metallopeptidase inhibitor 1), TMEM158(transmembrane protein 158), TNFAIP6(TNF alpha induced protein 6), VEGFA(vascular endothelial growth factor A), WNT5A(Wnt family member 5A), 및 GAPDH(glyceraldehyde-3-phosphate dehydrogenase)로 이루어진 군으로부터 선택되는 하나 이상의 유전자에 상보적인 프라이머(primer) 세트 또는 프로브 세트를 포함하는, 상처 치료제 스크리닝용 조성물을 제공한다.The present invention ACTA2 (alpha-action-2), BMPER (BMP binding endothelial regulator), CCL2 (chemokine ligand 2), CH25H (cholesterol 25-hydroxylase), COL1A1 (collagen type I alpha 1 chain), COL1A2 (collagen type I alpha 2 chain), COL3A1 (collagen type III alpha 1 chain), COL4A1 (collagen type IV alpha 1 chain), COL5A1 (collagen type V alpha 1 chain), COL5A2 (collagen type V alpha 2 chain), CSF3 (colony-stimulating) factor 3), CTGF (connective tissue growth factor), CTNNB1, CTSK (catherpsin K), CXCL1 (cxc motif chemokine ligand 1), CXCL5 (cxc motif chemokine ligand 5), CXCL6 (cxc motif chemokine ligand 6), DUSP6 (dual specificity phosphatase 6), epidermal growth factor receptor (EGFR), early growth response 1 (EGR1), epithelial membrane protein 1 (EMP1), enolase 1 (ENO1), ERBB receptor feedback inhibitor 1 (ERRFI1), endothelial cell specific molecule (ESM1) 1), fibrinogen alpha chain (FGA), fibroblast growth factor 2 (FGF2), fibroblast growth factor 7 (FGF7), fibroblast growth factor 10 (FGF10), FOSL1 (FOS like 1, AP-1 tran scription factor subunit (FST), follistatin (FST), hyaluronan synthase 2 (HAS2), heparin binding EGF like growth factor (HBEGF), hepatocyte growth factor (HGF), high mobility group AT-hook 2 (HMGA2), intercellular adhesion molecule (ICAM1) 1), IER3 (immediate early response 3), IL-13RA2 (interleukin 13 receptor, alpha 2), IL-33 (interleukin 33), IL-1B (interleukin 1 beta), IL-6 (interleukin 6), IL- 6ST(interleukin 6 signal transducer), IL-7R(interleukin 7 receptor), IL-8(interleukin 8), ITGA1(integrin subunit alpha 1), ITGA2(integrin subunit alpha 2), ITGA3(integrin subunit alpha 3), ITGA4 (integrin subunit alpha 4), ITGA5 (integrin subunit alpha 5), ITGAV (integrin subunit alpha V), ITGB1 (integrin subunit beta 1), ITGB3 (integrin subunit beta 3), ITGB5 (integrin subunit beta 5), KRTAP1-5 (keratin associated protein 1-5), LPXN (leupaxin), MAPK1 (mitogen-activated protein kinase 1), MAPK3 (mitogen-activated protein kinase 3), MCL1 (MCL1, BCL2 family apoptosis regulator), MIF (macrophage migration inhibitory factor) ) , Matrix metallopeptidase 2 (MMP1), matrix metallopeptidase 2 (MMP2), matrix metallopeptidase 3 (MMP3), nicotinamide phosphoribosyltransferase (VISFATIN), neuronal PAS domain protein 2 (NPAS2), platelet derived growth factor subunit A (PDGFA), PLAT (plasminogen activator, tissue type), PLAU (plasminogen activator, urokinase), PLAUR (plasminogen activator, urokinase receptor), PLG (plasminogen), PTEN (phosphatase and tensin homolog), PTGS2 (prostaglandin-endoperoxide synthase 2), PTX3 (pentraxin) 3), RAC1 (Rac family small GTPase 1), RHOA (ras homolog family member A), SERPINB2 (serpin family B member 2), SERPINE1 (serpin family E member 1), SERPINE2 (serpin family E member 2), SLC20A1( solute carrier family 20 member 1), SLIT2 (slit guidance ligand 2), SMURF2 (SMAD specific E3 ubiquitin protein ligase 2), STAT3 (signal transducer and activator of transcription 3), STC1 (stanniocalcin 1), SDC4 (syndecan 4), TAGLN (transgelin), TFPI2 (tissue factor pathway inhibitor 2), TGFB1 (transforming growth factor beta 1 ), TGFBR3 (transforming growth factor beta receptor 3), TIMP1 (TIMP metallopeptidase inhibitor 1), TMEM158 (transmembrane protein 158), TNFAIP6 (TNF alpha induced protein 6), VEGFA (vascular endothelial growth factor A), WNT5A (Wnt family member) 5A), and a set of primers or probes complementary to one or more genes selected from the group consisting of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).

본 발명에서, 상기 상처 관련 유전자 92개는 cDNA 마이크로어레이 기술에 의해 확보되었다. 보다 더 구체적으로, 본 발명가들은 표피성장인자인 epidermal growth factor(EGF) 자극에 의한 상처치유에 밀접하게 관련된 skin dermal fibroblasts(피부 섬유아세포)의 반응으로 인한 유전자 발현의 변화를 알아보기 위해, 인간의 피부 섬유아세포에 표피성장인자인 EGF 단백질을 1, 10, 50 ng/mL 농도로 12시간 처리하였다. 그 후, 세포로부터 mRNA를 분리하여 0.5μg의 mRNA를 사용하여 cDNA를 합성하였다. 합성된 cDNA는 Affymetrix사의 GeneChip Human Gene 2.0 ST Array를 실시하고 유전자 발현의 증감을 분석하였다. 그 결과, 총 40,716개의 전사유전자 중 1ng/mL, 10ng/mL, 50ng/mL를 피부 섬유아세포에 12시간 동안 처리했을 때, 각각 294, 890, 667개의 2 배 이상 상향 조절된 유전자를 확인하였다. 분석된 2배 이상 상향 조절된 유전자들은 다시, 다음 몇 가지 기준에 의해서 2차 분석되었다. 먼저, chip의 결과에서 기본적으로 높은 시그널을 보인 유전자, 아직 상처치유에 관련되어 있지 않거나, 활발하게 보고 되어 기존에 상처 치유에 관련한 유전자 키드에 포함 되었거나 되어 있지 않은 유전자를 분석하여 총 92개의 유전자를 확보하였다.In the present invention, 92 wound-related genes were obtained by cDNA microarray technology. More specifically, the present inventors have investigated human changes in gene expression due to the response of skin dermal fibroblasts (skin fibroblasts) closely related to wound healing by stimulation of epidermal growth factor (EGF), an epidermal growth factor. Skin fibroblasts were treated with epidermal growth factor EGF protein at concentrations of 1, 10 and 50 ng/mL for 12 hours. Thereafter, mRNA was isolated from the cells, and cDNA was synthesized using 0.5 μg of mRNA. The synthesized cDNA was subjected to GeneChip Human Gene 2.0 ST Array of Affymetrix and analyzed the increase and decrease of gene expression. As a result, when 1ng/mL, 10ng/mL, and 50ng/mL of a total of 40,716 transgenes were treated with skin fibroblasts for 12 hours, 294, 890, and 667 2 times or more up-regulated genes were identified. Genes that were up-regulated more than 2-fold analyzed were again analyzed secondary by several criteria. First, by analyzing the gene that showed a high signal basically in the result of the chip, or not yet related to wound healing, or actively reported and included in the gene kit related to wound healing, a total of 92 genes were analyzed. Secured.

본 발명에서 사용되는 용어, "cDNA 마이크로어레이 기술"은 다양한 암, 감염병, 면역질환 등의 질병에 관련한 유전자 마커들을 확보하기 위해 사용한다. 이를 토대로 많은 질병을 보다 용이하게 진단하거나 예측하고, 질병 치료 제제의 효능을 효과적으로 탐색할 수 있다.The term "cDNA microarray technology" used in the present invention is used to secure genetic markers related to diseases such as various cancers, infectious diseases, and immune diseases. Based on this, many diseases can be more easily diagnosed or predicted, and the efficacy of a disease treatment agent can be effectively explored.

본 발명에서 사용되는 용어,"프라이머"는 적합한 온도에서 적합한 버퍼 내에서 적합한 조건(예를들면, 4종의 다른 뉴클레오시드 트리포스페이트 및 중합반응효소)에서 주형 - 지시 DNA 합성의 개시점으로 작용할 수 있는 단일 가닥의 올리고뉴클레오티드를 의미한다. 프라이머의 적합한 길이는 다양한 인자, 예를 들어, 온도와 프라이머의 용도에 따라 차이가 있지만, 전형적으로 15-35개의 뉴클레오티드이다. 짧은 프라이머는 주형과 충분히 안정된 혼성화 복합체를 형성하기 위하여 일반적으로 보다 낮은 온도를 요구할 수 있다. 용어 "정방향 프라이머(forward primer)" 및 "역방향 프라이머(reverseprimer)"는 중합효소 연쇄반응에 의해 증폭되는 주형의 일정한 부위의 3' 말단 및 5' 말단에 각각 결합하는 프라이머를 의미한다. 상기 프라이머는 주형의 한 부위에 혼성화 또는 어닐링되어, 이중 쇄 구조를 형성할 수 있다. 이러한 이중 쇄 구조를 형성하는데 적합한 핵산 혼성화의 조건은 당업자에게 잘 알려져 있으나 이에 제한되지 않는다.As used herein, the term “primer” will serve as a starting point for template-directed DNA synthesis in suitable conditions (eg, four different nucleoside triphosphates and polymerases) in a suitable buffer at a suitable temperature. Means a single-stranded oligonucleotide. The suitable length of the primer varies depending on various factors, such as temperature and use of the primer, but is typically 15-35 nucleotides. Short primers may generally require lower temperatures to form sufficiently stable hybridization complexes with the template. The terms "forward primer" and "reverseprimer" refer to primers that bind to the 3'end and the 5'end of a constant region of a template amplified by a polymerase chain reaction, respectively. The primer may hybridize or anneal to one site of the template to form a double chain structure. Conditions for nucleic acid hybridization suitable for forming such a double chain structure are well known to those skilled in the art, but are not limited thereto.

본 발명에 있어서, 상기 프라이머 세트는 서열번호 1 및 서열번호 2로 표시되는 염기서열로 이루어진 ACTA2검출용 프라이머 세트, 서열번호 3 및 서열번호 4로 표시되는 염기서열로 이루어진 BMPER검출용 프라이머 세트, 서열번호 5 및 서열번호 6로 표시되는 염기서열로 이루어진 CCL2검출용 프라이머 세트, 서열번호 7 및 서열번호 8로 표시되는 염기서열로 이루어진 CH25H검출용 프라이머 세트, 서열번호 9 및 서열번호 10로 표시되는 염기서열로 이루어진 COL1A1검출용 프라이머 세트, 서열번호 11 및 서열번호 12로 표시되는 염기서열로 이루어진 COL1A2검출용 프라이머 세트, 서열번호 13 및 서열번호 14로 표시되는 염기서열로 이루어진 COL3A1검출용 프라이머 세트, 서열번호 15 및 서열번호 16로 표시되는 염기서열로 이루어진 COL4A1검출용 프라이머 세트, 서열번호 17 및 서열번호 18로 표시되는 염기서열로 이루어진 COL5A1검출용 프라이머 세트, 서열번호 19 및 서열번호 20로 표시되는 염기서열로 이루어진 COL5A2검출용 프라이머 세트, 서열번호 21 및 서열번호 22로 표시되는 염기서열로 이루어진 CSF3검출용 프라이머 세트, 서열번호 23 및 서열번호 24로 표시되는 염기서열로 이루어진 CTGF검출용 프라이머 세트, 서열번호 25 및 서열번호 26로 표시되는 염기서열로 이루어진 CTNNB1검출용 프라이머 세트, 서열번호 27 및 서열번호 28로 표시되는 염기서열로 이루어진 CTSK검출용 프라이머 세트, 서열번호 29 및 서열번호 30로 표시되는 염기서열로 이루어진 CXCL1검출용 프라이머 세트, 서열번호 31 및 서열번호 32로 표시되는 염기서열로 이루어진 CXCL5검출용 프라이머 세트, 서열번호 33 및 서열번호 34로 표시되는 염기서열로 이루어진 CXCL6검출용 프라이머 세트, 서열번호 35 및 서열번호 36로 표시되는 염기서열로 이루어진 DUSP6검출용 프라이머 세트, 서열번호 37 및 서열번호 38로 표시되는 염기서열로 이루어진 EGFR검출용 프라이머 세트, 서열번호 39 및 서열번호 40로 표시되는 염기서열로 이루어진 EGR1검출용 프라이머 세트, 서열번호 41 및 서열번호 42로 표시되는 염기서열로 이루어진 EMP1검출용 프라이머 세트, 서열번호 43 및 서열번호 44로 표시되는 염기서열로 이루어진 ENO1검출용 프라이머 세트, 서열번호 45 및 서열번호 46로 표시되는 염기서열로 이루어진 ERRFI1검출용 프라이머 세트, 서열번호 47 및 서열번호 48로 표시되는 염기서열로 이루어진 ESM1검출용 프라이머 세트, 서열번호 49 및 서열번호 50로 표시되는 염기서열로 이루어진 FGA검출용 프라이머 세트, 서열번호 51 및 서열번호 52로 표시되는 염기서열로 이루어진 FGF10검출용 프라이머 세트, 서열번호 53 및 서열번호 54로 표시되는 염기서열로 이루어진 FGF2검출용 프라이머 세트, 서열번호 55 및 서열번호 56로 표시되는 염기서열로 이루어진 FGF7검출용 프라이머 세트, 서열번호 57 및 서열번호 58로 표시되는 염기서열로 이루어진 FOSL1검출용 프라이머 세트, 서열번호 59 및 서열번호 60로 표시되는 염기서열로 이루어진 FST검출용 프라이머 세트, 서열번호 61 및 서열번호 62로 표시되는 염기서열로 이루어진 HAS2검출용 프라이머 세트, 서열번호 63 및 서열번호 64로 표시되는 염기서열로 이루어진 HBEGF검출용 프라이머 세트, 서열번호 65 및 서열번호 66로 표시되는 염기서열로 이루어진 HGF검출용 프라이머 세트, 서열번호 67 및 서열번호 68로 표시되는 염기서열로 이루어진 HMGA2검출용 프라이머 세트, 서열번호 69 및 서열번호 70로 표시되는 염기서열로 이루어진 ICAM1검출용 프라이머 세트, 서열번호 71 및 서열번호 72로 표시되는 염기서열로 이루어진 IER3검출용 프라이머 세트, 서열번호 73 및 서열번호 74로 표시되는 염기서열로 이루어진 IL-13RA2검출용 프라이머 세트, 서열번호 75 및 서열번호 76로 표시되는 염기서열로 이루어진 IL-33검출용 프라이머 세트, 서열번호 77 및 서열번호 78로 표시되는 염기서열로 이루어진 IL-1B검출용 프라이머 세트, 서열번호 79 및 서열번호 80로 표시되는 염기서열로 이루어진 IL-6검출용 프라이머 세트, 서열번호 81 및 서열번호 82로 표시되는 염기서열로 이루어진 IL-6ST검출용 프라이머 세트, 서열번호 83 및 서열번호 84로 표시되는 염기서열로 이루어진 IL-7R검출용 프라이머 세트, 서열번호 85 및 서열번호 86로 표시되는 염기서열로 이루어진 IL-8검출용 프라이머 세트, 서열번호 87 및 서열번호 88로 표시되는 염기서열로 이루어진 ITGA1검출용 프라이머 세트, 서열번호 89 및 서열번호 90로 표시되는 염기서열로 이루어진 ITGA2검출용 프라이머 세트, 서열번호 91 및 서열번호 92로 표시되는 염기서열로 이루어진 ITGA3검출용 프라이머 세트, 서열번호 93 및 서열번호 94로 표시되는 염기서열로 이루어진 ITGA4검출용 프라이머 세트, 서열번호 95 및 서열번호 96로 표시되는 염기서열로 이루어진 ITGA5검출용 프라이머 세트, 서열번호 97 및 서열번호 98로 표시되는 염기서열로 이루어진 ITGAV검출용 프라이머 세트, 서열번호 99 및 서열번호 100로 표시되는 염기서열로 이루어진 ITGB1검출용 프라이머 세트, 서열번호 101 및 서열번호 102로 표시되는 염기서열로 이루어진 ITGB3검출용 프라이머 세트, 서열번호 103 및 서열번호 104로 표시되는 염기서열로 이루어진 ITGB5검출용 프라이머 세트, 서열번호 105 및 서열번호 106로 표시되는 염기서열로 이루어진 KRTAP1-5검출용 프라이머 세트, 서열번호 107 및 서열번호 108로 표시되는 염기서열로 이루어진 LPXN검출용 프라이머 세트, 서열번호 109 및 서열번호 1110로 표시되는 염기서열로 이루어진 MAPK1검출용 프라이머 세트, 서열번호 111 및 서열번호 112로 표시되는 염기서열로 이루어진 MAPK3검출용 프라이머 세트, 서열번호 113 및 서열번호 114로 표시되는 염기서열로 이루어진 MCL1검출용 프라이머 세트, 서열번호 115 및 서열번호 116로 표시되는 염기서열로 이루어진 MIF검출용 프라이머 세트, 서열번호 117 및 서열번호 118로 표시되는 염기서열로 이루어진 MMP1검출용 프라이머 세트, 서열번호 119 및 서열번호 120로 표시되는 염기서열로 이루어진 MMP2검출용 프라이머 세트, 서열번호 121 및 서열번호 122로 표시되는 염기서열로 이루어진 MMP3검출용 프라이머 세트, 서열번호 123 및 서열번호 124로 표시되는 염기서열로 이루어진 VISFATIN검출용 프라이머 세트, 서열번호 125 및 서열번호 126로 표시되는 염기서열로 이루어진 NPAS2검출용 프라이머 세트, 서열번호 127 및 서열번호 128로 표시되는 염기서열로 이루어진 PDGFA검출용 프라이머 세트, 서열번호 129 및 서열번호 130로 표시되는 염기서열로 이루어진 PLAT검출용 프라이머 세트, 서열번호 131 및 서열번호 132로 표시되는 염기서열로 이루어진 PLAU검출용 프라이머 세트, 서열번호 133 및 서열번호 134로 표시되는 염기서열로 이루어진 PLAUR검출용 프라이머 세트, 서열번호 135 및 서열번호 136로 표시되는 염기서열로 이루어진 PLG검출용 프라이머 세트, 서열번호 137 및 서열번호 138로 표시되는 염기서열로 이루어진 PTEN검출용 프라이머 세트, 서열번호 139 및 서열번호 140로 표시되는 염기서열로 이루어진 PTGS2검출용 프라이머 세트, 서열번호 141 및 서열번호 142로 표시되는 염기서열로 이루어진 PTX3검출용 프라이머 세트, 서열번호 143 및 서열번호 144로 표시되는 염기서열로 이루어진 RAC1검출용 프라이머 세트, 서열번호 145 및 서열번호 146로 표시되는 염기서열로 이루어진 RHOA검출용 프라이머 세트, 서열번호 147 및 서열번호 148로 표시되는 염기서열로 이루어진 SERPINB2검출용 프라이머 세트, 서열번호 149 및 서열번호 150로 표시되는 염기서열로 이루어진 SERPINE1검출용 프라이머 세트, 서열번호 151 및 서열번호 152로 표시되는 염기서열로 이루어진 SERPINE2검출용 프라이머 세트, 서열번호 153 및 서열번호 154로 표시되는 염기서열로 이루어진 SLC20A1검출용 프라이머 세트, 서열번호 155 및 서열번호 156로 표시되는 염기서열로 이루어진 SLIT2검출용 프라이머 세트, 서열번호 157 및 서열번호 158로 표시되는 염기서열로 이루어진 SMURF2검출용 프라이머 세트, 서열번호 159 및 서열번호 160로 표시되는 염기서열로 이루어진 STAT3검출용 프라이머 세트, 서열번호 161 및 서열번호 162로 표시되는 염기서열로 이루어진 STC1검출용 프라이머 세트, 서열번호 163 및 서열번호 164로 표시되는 염기서열로 이루어진 SDC4검출용 프라이머 세트, 서열번호 165 및 서열번호 166로 표시되는 염기서열로 이루어진 TAGLN검출용 프라이머 세트, 서열번호 167 및 서열번호 168로 표시되는 염기서열로 이루어진 TFPI2검출용 프라이머 세트, 서열번호 169 및 서열번호 170로 표시되는 염기서열로 이루어진 TGFB1검출용 프라이머 세트, 서열번호 171 및 서열번호 172로 표시되는 염기서열로 이루어진 TGFBR3검출용 프라이머 세트, 서열번호 173 및 서열번호 174로 표시되는 염기서열로 이루어진 TIMP1검출용 프라이머 세트, 서열번호 175 및 서열번호 176로 표시되는 염기서열로 이루어진 TMEM158검출용 프라이머 세트, 서열번호 177 및 서열번호 178로 표시되는 염기서열로 이루어진 TNFAIP6검출용 프라이머 세트, 서열번호 179 및 서열번호 180로 표시되는 염기서열로 이루어진 VEGFA검출용 프라이머 세트, 서열번호 181 및 서열번호 182로 표시되는 염기서열로 이루어진 WNT5A검출용 프라이머 세트, 또는, 서열번호 183 및 서열번호 184로 표시되는 염기서열로 이루어진 GAPDH 검출용 프라이머 세트일 수 있으나 이에 제한되지 않는다.In the present invention, the primer set is a primer set for detecting ACTA2 consisting of a nucleotide sequence represented by SEQ ID NO: 1 and SEQ ID NO: 2, a primer set for detecting BMPER consisting of a nucleotide sequence represented by SEQ ID NO: 3 and SEQ ID NO: 4, a sequence CCL2 detection primer set consisting of nucleotide sequence represented by SEQ ID NO: 5 and SEQ ID NO: 6, CH25H detection primer set consisting of nucleotide sequence represented by SEQ ID NO: 7 and SEQ ID NO: 8, base represented by SEQ ID NO: 9 and SEQ ID NO: 10 COL1A1 detection primer set consisting of sequence, COL1A2 detection primer set consisting of nucleotide sequence represented by SEQ ID NO: 11 and SEQ ID NO: 12, COL3A1 detection primer set consisting of nucleotide sequence shown by SEQ ID NO: 13 and SEQ ID NO: 14, sequence Primer set for detecting COL4A1 consisting of the nucleotide sequence represented by SEQ ID NO: 15 and SEQ ID NO: 16, Primer set for detecting COL5A1 consisting of the nucleotide sequence represented by SEQ ID NO: 17 and SEQ ID NO: 18, Base represented by SEQ ID NO: 19 and SEQ ID NO: 20 COL5A2 detection primer set consisting of sequence, CSF3 detection primer set consisting of nucleotide sequence represented by SEQ ID NO: 21 and SEQ ID NO: 22, CTGF detection primer set consisting of nucleotide sequence shown by SEQ ID NO: 23 and SEQ ID NO: 24, sequence Primer set for detecting CTNNB1 consisting of the nucleotide sequence represented by SEQ ID NO: 25 and SEQ ID NO: 26, Primer set for detecting CTSK consisting of the nucleotide sequence represented by SEQ ID NO: 27 and SEQ ID NO: 28, Base represented by SEQ ID NO: 29 and SEQ ID NO: 30 CXCL1 detection primer set consisting of sequence, CXCL5 detection primer set consisting of nucleotide sequence represented by SEQ ID NO: 31 and SEQ ID NO: 32, CXCL6 detection primer set consisting of nucleotide sequence shown by SEQ ID NO: 33 and SEQ ID NO: 34, sequence Primer set for detection of DUSP6 consisting of the nucleotide sequence shown in SEQ ID NO: 35 and SEQ ID NO: 36, as the nucleotide sequence shown in SEQ ID NO: 37 and SEQ ID NO: 38 A primer set for detecting EGFR, a primer set for detecting EGR1 consisting of the nucleotide sequence represented by SEQ ID NO: 39 and SEQ ID NO: 40, a primer set for detecting EMP1 consisting of the nucleotide sequence shown by SEQ ID NO: 41 and SEQ ID NO: 42, SEQ ID NO: 43 And a primer set for detecting ENO1 consisting of the nucleotide sequence represented by SEQ ID NO: 44, a primer set for detecting ERRFI1 consisting of the nucleotide sequence represented by SEQ ID NO: 45 and SEQ ID NO: 46, as a nucleotide sequence represented by SEQ ID NO: 47 and SEQ ID NO: 48 A primer set for detecting ESM1, a primer set for detecting FGA consisting of a nucleotide sequence represented by SEQ ID NO: 49 and SEQ ID NO: 50, a primer set for detecting FGF10 consisting of a nucleotide sequence represented by SEQ ID NO: 51 and SEQ ID NO: 52, SEQ ID NO: 53 And a primer set for detecting FGF2 consisting of the nucleotide sequence represented by SEQ ID NO: 54, a primer set for detecting FGF7 consisting of the nucleotide sequence represented by SEQ ID NO: 55 and SEQ ID NO: 56, and a nucleotide sequence represented by SEQ ID NO: 57 and SEQ ID NO: 58 FOSL1 detection primer set, consisting of the nucleotide sequence shown in SEQ ID NO: 59 and SEQ ID NO: 60 FST detection primer set, SEQ ID NO: 61 and SEQ ID NO: 62 consisting of the nucleotide sequence HAS2 detection primer set, SEQ ID NO: 63 And a primer set for HBEGF detection consisting of the nucleotide sequence represented by SEQ ID NO: 64, a primer set for HGF detection consisting of the nucleotide sequence represented by SEQ ID NO: 65 and SEQ ID NO: 66, and a nucleotide sequence represented by SEQ ID NO: 67 and SEQ ID NO: 68 A primer set for detecting HMGA2, a primer set for detecting ICAM1 consisting of the nucleotide sequence represented by SEQ ID NO: 69 and SEQ ID NO: 70, a primer set for detecting IER3 consisting of the nucleotide sequence represented by SEQ ID NO: 71 and SEQ ID NO: 72, SEQ ID NO: 73 And a primer set for detecting IL-13RA2 consisting of the nucleotide sequence represented by SEQ ID NO: 74, consisting of the nucleotide sequence represented by SEQ ID NO: 75 and SEQ ID NO: 76 Primer set for detecting gene IL-33, primer set for detecting IL-1B consisting of the nucleotide sequence represented by SEQ ID NO: 77 and SEQ ID NO: 78, for detecting IL-6 consisting of the nucleotide sequence represented by SEQ ID NO: 79 and SEQ ID NO: 80 Primer set, primer set for detecting IL-6ST consisting of the nucleotide sequence represented by SEQ ID NO: 81 and SEQ ID NO: 82, primer set for detecting IL-7R consisting of the nucleotide sequence represented by SEQ ID NO: 83 and SEQ ID NO: 84, SEQ ID NO: 85 And a primer set for detecting IL-8 consisting of a nucleotide sequence represented by SEQ ID NO: 86, a primer set for detecting ITGA1 consisting of a nucleotide sequence represented by SEQ ID NO: 87 and SEQ ID NO: 88, a base represented by SEQ ID NO: 89 and a SEQ ID NO: 90 ITGA2 detection primer set consisting of sequence, ITGA3 detection primer set consisting of nucleotide sequence represented by SEQ ID NO: 91 and SEQ ID NO: 92, ITGA4 detection primer set consisting of nucleotide sequence shown by SEQ ID NO: 93 and SEQ ID NO: 94, sequence ITGA5 detection primer set consisting of nucleotide sequences represented by SEQ ID NO: 95 and SEQ ID NO: 96, ITGAV detection primer set consisting of nucleotide sequences represented by SEQ ID NO: 97 and SEQ ID NO: 98, base represented by SEQ ID NO: 99 and SEQ ID NO: 100 ITGB1 detection primer set consisting of sequence, ITGB3 detection primer set consisting of nucleotide sequence represented by SEQ ID NO: 101 and SEQ ID NO: 102, ITGB5 detection primer set consisting of nucleotide sequence shown by SEQ ID NO: 103 and SEQ ID NO: 104, sequence Primer set for detecting KRTAP1-5 consisting of the nucleotide sequence represented by SEQ ID NO: 105 and SEQ ID NO: 106, Primer set for detecting LPXN consisting of the base sequence represented by SEQ ID NO: 107 and SEQ ID NO: 108, represented by SEQ ID NO: 109 and SEQ ID NO: 1110 Primer set for detecting MAPK1 consisting of nucleotide sequence to be used, Primer set for detecting MAPK3 consisting of nucleotide sequence shown in SEQ ID NO: 111 and SEQ ID NO: 112, SEQ ID NO: 113 and Primer set for MCL1 detection consisting of the nucleotide sequence represented by SEQ ID NO: 114, primer set for MIF detection consisting of the nucleotide sequence represented by SEQ ID NO: 115 and SEQ ID NO: 116, consisting of the nucleotide sequence represented by SEQ ID NO: 117 and SEQ ID NO: 118 Primer set for MMP1 detection, primer set for MMP2 detection consisting of the nucleotide sequence represented by SEQ ID NO: 119 and SEQ ID NO: 120, primer set for MMP3 detection consisting of the nucleotide sequence shown by SEQ ID NO: 121 and SEQ ID NO: 122, SEQ ID NO: 123 and A primer set for detecting VISFATIN consisting of the nucleotide sequence represented by SEQ ID NO: 124, a primer set for detecting NPAS2 consisting of the nucleotide sequence represented by SEQ ID NO: 125 and SEQ ID NO: 126, consisting of a nucleotide sequence represented by SEQ ID NO: 127 and SEQ ID NO: 128 A primer set for PDGFA detection, a primer set for PLAT detection consisting of the nucleotide sequence represented by SEQ ID NO: 129 and SEQ ID NO: 130, a primer set for PLAU detection consisting of the nucleotide sequence represented by SEQ ID NO: 131 and SEQ ID NO: 132, SEQ ID NO: 133 and A primer set for PLAUR detection consisting of a nucleotide sequence represented by SEQ ID NO: 134, a primer set for PLG detection consisting of a nucleotide sequence represented by SEQ ID NO: 135 and SEQ ID NO: 136, consisting of a nucleotide sequence represented by SEQ ID NO: 137 and SEQ ID NO: 138 PTEN detection primer set, PTGS2 detection primer set consisting of the nucleotide sequence shown in SEQ ID NO: 139 and SEQ ID NO: 140, PTX3 detection primer set consisting of the nucleotide sequence shown in SEQ ID NO: 141 and SEQ ID NO: 142, SEQ ID NO: 143 and Primer set for detecting RAC1 consisting of the nucleotide sequence represented by SEQ ID NO: 144, Primer set for detecting RHOA consisting of the nucleotide sequence represented by SEQ ID NO: 145 and SEQ ID NO: 146, consisting of the nucleotide sequence represented by SEQ ID NO: 147 and SEQ ID NO: 148 Primer set for detection of SERPINB2, base sequence represented by SEQ ID NO: 149 and SEQ ID NO: 150 Primer set for detecting SERPINE1 consisting of columns, primer set for detecting SERPINE2 consisting of the nucleotide sequence represented by SEQ ID NO: 151 and SEQ ID NO: 152, primer set for detecting SLC20A1 consisting of the nucleotide sequence shown by SEQ ID NO: 153 and SEQ ID NO: 154, SEQ ID NO: A primer set for detecting SLIT2 consisting of the nucleotide sequence represented by 155 and SEQ ID NO: 156, a primer set for detecting SMURF2 consisting of the nucleotide sequence represented by SEQ ID NO: 157 and SEQ ID NO: 158, a nucleotide sequence represented by SEQ ID NO: 159 and SEQ ID NO: 160 A primer set for detecting STAT3 consisting of, a primer set for detecting STC1 consisting of a nucleotide sequence represented by SEQ ID NO: 161 and SEQ ID NO: 162, a primer set for detecting SDC4 consisting of a nucleotide sequence represented by SEQ ID NO: 163 and SEQ ID NO: 164, a SEQ ID NO: A primer set for detecting TAGLN consisting of a base sequence represented by 165 and SEQ ID NO: 166, a primer set for detecting TFPI2 consisting of a base sequence represented by SEQ ID NO: 167 and SEQ ID NO: 168, a base sequence represented by SEQ ID NO: 169 and SEQ ID NO: 170 A primer set for detecting TGFB1 consisting of, a primer set for detecting TGFBR3 consisting of a nucleotide sequence represented by SEQ ID NO: 171 and SEQ ID NO: 172, a primer set for detecting TIMP1 consisting of a nucleotide sequence represented by SEQ ID NO: 173 and SEQ ID NO: 174, a SEQ ID NO: Primer set for detecting TMEM158 consisting of the nucleotide sequence represented by 175 and SEQ ID NO: 176, Primer set for detecting TNFAIP6 consisting of the nucleotide sequence represented by SEQ ID NO: 177 and SEQ ID NO: 178, base sequence represented by SEQ ID NO: 179 and SEQ ID NO: 180 A primer set for detecting VEGFA consisting of, a primer set for detecting WNT5A composed of a nucleotide sequence represented by SEQ ID NO: 181 and SEQ ID NO: 182, or a primer set for detecting GAPDH composed of a nucleotide sequence represented by SEQ ID NO: 183 and SEQ ID NO: 184 However, it is not limited thereto.

본 발명에서 사용되는 용어, "프로브"는 특정 폴리뉴클레오티드 서열에 혼성화될 수 있는데 옥시리보뉴클레오티드 및/또는 리보뉴클레오티드를 포함하는 자연 또는 변형된 단량체(monomer) 또는 결합을 갖는 선형의 올리고머(oligomer)를 의미한다. 예를 들어, 상기 프로브는 혼성화의 효율을 높일 수 있도록 단일가닥일 수 있다. 상기 프로브는 주형이 되는 폴리뉴클레오티드 서열에 완전하게 상보적인 서열일 수 있으나, 특이적 혼성화를 방해하지 않는 범위 내에서 실질적으로 상보적인 서열일 수도 있고, 방사성 동위원소나 효소 등을 표지하여 mRNA의 존재 유무를 확인할 수 있으며, 공지된 방법으로 디자인하고 변형시켜 사용할 수 있다. As used herein, the term “probe” can hybridize to a specific polynucleotide sequence, which refers to a linear or oligomer having a natural or modified monomer or bond comprising oxyribonucleotides and/or ribonucleotides. it means. For example, the probe may be single-stranded to increase the efficiency of hybridization. The probe may be a sequence completely complementary to the polynucleotide sequence as a template, but may be a substantially complementary sequence within a range that does not interfere with specific hybridization, or the presence of mRNA by labeling a radioisotope or an enzyme. It can be checked for presence or absence and can be designed and modified in a known manner.

본 발명에 있어서, 상기 프로브 세트는 형광 표지 물질을 갖는 표시 프로브 세트일 수 있으나, 이에 제한되지 않으며, 상기 표지물질은, 특별히 제한되지 않고, 예를 들면, 상기 표지 프로브가 단독인지, 하이브리드를 형성하고 있는지에 따라, 시그널을 발하는 것이 바람직하다. 상기 시그널의 종류는, 특별히 제한되지 않고, 예를 들면, 형광, 정색 등을 들 수 있다. 상기 정색은, 예를 들면, 발색이어도 되며, 변색이어도 된다. 상기 시그널이 형광의 경우, 시그널 값은, 예를 들면, 형광 강도를 들 수 있다. 상기 시그널이 정색의 경우, 상기 시그널 값은, 예를 들면, 반사율, 흡광도, 투과율 등을 들 수 있다. 상기 시그널은, 예를 들면, 상기 표지물질로부터 직접발해도 되며, 간접적으로 발해도 된다. 상기 표지물질은, 특별히 제한되지 않고, 예를 들면, 형광단 등의 형광표지 물질 등을 들 수 있다. 상기 형광물질은, 예를 들면, 플루오레세인, 인광체, 로다민, 폴리메틴색소 유도체 등을 들 수 있으나, 이에 제한되지 않는다.In the present invention, the probe set may be a set of display probes having a fluorescent labeling material, but is not limited thereto, and the labeling material is not particularly limited, for example, whether the labeling probe is alone or forms a hybrid. Depending on what you are doing, it is desirable to emit a signal. The type of the signal is not particularly limited, and examples thereof include fluorescence, coloration, and the like. The coloration may be, for example, color development, or color change. When the signal is fluorescence, the signal value is, for example, fluorescence intensity. When the signal is colored, the signal value includes, for example, reflectance, absorbance, transmittance, and the like. The signal may be emitted directly from the labeling material, for example, or indirectly. The labeling material is not particularly limited, and examples thereof include a fluorescent labeling material such as a fluorophore. Examples of the fluorescent material include, but are not limited to, fluorescein, phosphor, rhodamine, polymethine pigment derivatives, and the like.

또한, 본 발명은 상기 92개의 단백질들로 이루어진 군으로부터 선택되는 하나 이상의 단백질에 특이적으로 결합하는 항체, 압타머, 또는 리간드를 포함하는, 상처 치료제 스크리닝용 조성물을 제공한다.In addition, the present invention provides a composition for screening a wound treatment, comprising an antibody, an aptamer, or a ligand that specifically binds one or more proteins selected from the group consisting of the 92 proteins.

본 발명에서 사용되는 용어, “항체”는 면역학적으로 특정 항원과 반응성을 갖는 면역글로불린 분자를 포함하며, 단클론(monoclonal) 항체 및 다클론(polyclonal) 항체를 모두 포함한다. 또한, 상기 항체는 키메라성 항체(예를 들면, 인간화 뮤린 항체) 및 이종결합항체(예를 들면, 양특이성 항체)와 같은 유전공학에 의해 생산된 형태를 포함한다. As used in the present invention, the term “antibody” includes immunoglobulin molecules that are immunologically reactive with a specific antigen, and includes both monoclonal and polyclonal antibodies. In addition, the antibodies include forms produced by genetic engineering such as chimeric antibodies (eg, humanized murine antibodies) and heterologous antibodies (eg, bispecific antibodies).

본 발명에서 사용되는 용어, "압타머" 는 특정 물질에 대해 높은 특이성과 친화도를 가지는 단일가닥 DNA(ssDNA) 또는 RNA이다. 기존에 개발되어 있는 항체를 이용한 방법은 생체의 면역 시스템을 이용하여 만들어지기 때문에 비교적 많은 시간이 들고 고비용이라는 점, 단백질이기 때문에 그 안정성이 문제가 되는 경우가 있는 반면, 압타머는 합성에 있어서, 비교적 단순한 방법으로 가능하고 세포, 단백질, 그리고 작은 유기 물질까지도 표적물질이 될 수 있기 때문에, 이를 이용한 새로운 검출 방법들의 개발이 가능하며, 그 특이성 및 안정성이 이미 개발되어 있는 항체에 비해 매우 높다.The term "aptamer" used in the present invention is a single-stranded DNA (ssDNA) or RNA having high specificity and affinity for a specific substance. The method using an antibody developed in the past is relatively time-consuming and expensive because it is made using a biological immune system, and its stability may be a problem because it is a protein, whereas aptamers are relatively synthetic in synthesis. Since it is possible by a simple method and can target cells, proteins, and even small organic substances, it is possible to develop new detection methods using the same, and its specificity and stability are very high compared to antibodies that have already been developed.

본 발명에 사용되는 용어, "리간드"는 유기물질, 단백질, 펩타이드 등을 포함하는 표적물질에 결합하는 물질로 하는 것을 특징으로 하나, 이에 제한되지 않는다.As used in the present invention, the term "ligand" is characterized by being a material that binds to a target material, including organic materials, proteins, peptides, etc., but is not limited thereto.

또한, 본 발명은 상기 상처 치료제 스크리닝용 조성물을 포함하는 상처 치료제 스크리닝용 키트를 제공한다.In addition, the present invention provides a kit for screening a wound treatment comprising the composition for screening a wound treatment.

상기 키트는 예를 들어, 표적핵산을 증폭하기 위한 키트일 수 있다. 증폭은 핵산증폭을 위하여 알려진 방법일 수 있다. 증폭은 예를 들면, DNA 증폭 또는 RNA 증폭일 수 있다. 증폭방법은 열순환(termal cycling)을 필요로 하는 것 또는 등온 (isothermal)에서 수행되는 것일 수 있다. 상기 증폭방법은 폴리머라제 연쇄반응 (polymerase chainreaction: PCR), 핵산서열-기초증폭(nucleic acid sequence-based amplification: NASBA), 리가제연쇄반응(ligase chain reaction: LCR), 가닥치환증폭(strand displacement amplificaton: SDA), 롤링 서클 증폭(rolling circle amplification: RCA) 등을 포함할 수 있다. 증폭 방법은 또한, RNA 증폭 방법을 포함할 수 있다. 예를 들면, 역전사(reverse transcription: RT) 또는 역전사-PCR을 포함할 수 있다. 증폭이란 표적핵산서열 또는 그에 상보적인 서열의 카피수를 증가시키는 것 일 수 있다. "PCR"은 중합효소를 이용하여 표적핵산에 특이적으로 결합하는 프라이머 쌍으로부터 표적핵산을 증폭하는 방법일 수 있다. 또한, 상기 키트는 표적핵산의 증폭에 요구되는 알려진 물질을 더 포함할 수 있다. 예를 들면, 키트는 핵산폴리머라제, 그의 활성에 필요한 버퍼, 보조인자, 및/또는 기질을 더 포함할 수 있다. 상기 핵산폴리머라제는 DNA 폴리머라제, RNA 폴리머라제, 역전사효소(reverse transcriptase) 및 이들의 조합일 수 있다. 역전사(reverse transcription)란 RNA를 주형으로 하여 RNA 서열에 상보적인 DNA 가닥을 합성하는 것 일 수 있다. 상기 핵산폴리머라제는 가닥치환활성을 갖는 것 일 수 있다. 예를 들면, 레트로바이러스, 예를 들면, HIV, MMLV, 및 AMV로부터 유래된 역전사효소 일 수 있다. 상기 핵산폴리머라제는 3'-> 5' 엑소뉴클레아제활성(exonuclease activity)을 갖지 않는 것 일 수 있다. 상기 키트는 역전사 또는 PCR 증폭에 필요한 물질을 포함하는 것 일 수 있으며, 바람직하게는 96-웰 실시간 유전자 중합반응 어레이 키트일 수 있으나, 이에 제한되지 않는다.The kit may be, for example, a kit for amplifying a target nucleic acid. Amplification may be a known method for nucleic acid amplification. The amplification can be, for example, DNA amplification or RNA amplification. The amplification method may be one that requires thermal cycling or isothermal. The amplification method is polymerase chain reaction (PCR), nucleic acid sequence-based amplification (NASBA), ligase chain reaction (LCR), strand displacement amplificaton : SDA), rolling circle amplification (RCA), and the like. Amplification methods may also include RNA amplification methods. For example, reverse transcription (RT) or reverse transcription-PCR may be included. Amplification may be to increase the number of copies of a target nucleic acid sequence or a sequence complementary thereto. "PCR" may be a method of amplifying a target nucleic acid from a primer pair that specifically binds to the target nucleic acid using a polymerase. In addition, the kit may further include a known substance required for amplification of the target nucleic acid. For example, the kit may further include a nucleic acid polymerase, a buffer necessary for its activity, a cofactor, and/or a substrate. The nucleic acid polymerase may be DNA polymerase, RNA polymerase, reverse transcriptase, and combinations thereof. Reverse transcription may be to synthesize a DNA strand complementary to an RNA sequence using RNA as a template. The nucleic acid polymerase may have a strand substitution activity. For example, it can be a reverse transcriptase derived from a retrovirus, such as HIV, MMLV, and AMV. The nucleic acid polymerase may be one that does not have 3'-> 5'exonuclease activity. The kit may include a material necessary for reverse transcription or PCR amplification, and preferably a 96-well real-time gene polymerization array kit, but is not limited thereto.

또한, 본 발명은 (a) 섬유아세포에 분석하고자 하는 시료를 처리하는 단계;In addition, the present invention (a) processing a sample to be analyzed for fibroblasts;

(b) 상기 섬유아세포에서 상기 92개의 유전자들로 이루어진 군으로부터 선택되는 하나 이상의 유전자 발현량을 측정하는 단계; 및 (c)상기 시료의 처리로 (b)단계에서 유전자 발현량이 증가하는 경우 상처치료제로 선별하는 단계를 포함하는, 상처 치료제를 스크리닝하는 방법을 제공한다.(b) measuring the expression level of one or more genes selected from the group consisting of the 92 genes in the fibroblasts; And (c) provides a method for screening a wound treatment, comprising the step of screening with a wound treatment agent when the gene expression in step (b) increases with the treatment of the sample.

본 발명에 있어서, 상기 시료는 섬유아세포에서 발현되는 유전자의 발현량을 측정하기 위하여, 스크리닝에서 사용되는 미지의 물질을 의미하며, 바람직하게는 화합물, 미생물 배양액 또는 추출물, 천연물 추출물, 핵산, 및 펩타이드로 이루어진 군으로부터 선택되는 것일 수 있으며, 상기 핵산은 microRNA, siRNA, shRNA, 안티센스 RNA, 앱타머(aptamer), LNA(locked nucleic acid), PNA(peptide nucleic acid), 및 모폴리노(morpholino)로 이루어진 군으로부터 선택되는 것일 수 있으나, 이에 한정되는 것은 아니다.In the present invention, the sample means an unknown substance used in screening to measure the expression level of a gene expressed in fibroblasts, preferably a compound, a microbial culture or extract, a natural product extract, a nucleic acid, and a peptide It may be selected from the group consisting of, the nucleic acid is microRNA, siRNA, shRNA, antisense RNA, aptamer (aptamer), LNA (locked nucleic acid), PNA (peptide nucleic acid), and morpholino (morpholino) It may be selected from the group consisting, but is not limited thereto.

본 발명에서 사용되는 용어, “microRNA”란 약 22개의 염기서열로 이루어진 짧은 non-coding RNA를 의미한다. 유전자의 발현 과정에서 전사 후 조절인자(post-transcriptional regulator)로서 기능을 한다고 알려져 있다. 상보적인 염기 서열을 가진 표적(target) mRNA에 상보적으로 결합함으로써 표적 mRNA들을 분해시키거나 단백질로 번역되는 것을 억제한다.The term “microRNA” used in the present invention means a short non-coding RNA composed of about 22 base sequences. It is known that it functions as a post-transcriptional regulator in the gene expression process. Target mRNAs with complementary base sequences are complementarily bound to inhibit degradation of target mRNAs or translation into proteins.

본 발명에서 사용되는 용어, “siRNA(small interfering RNA)”란 특정 mRNA의 절단(cleavage)을 통하여 RNA간섭(RNA interference; RNAi) 현상을 유도할 수 있는 짧은 이중사슬 RNA를 의미한다. 타겟 유전자의 mRNA와 상동인 서열을 가지는 센스 RNA 가닥과 이와 상보적인 서열을 가지는 안티센스 RNA 가닥으로 구성된다. siRNA는 타겟 유전자의 발현을 억제할 수 있기 때문에 효율적인 유전자 넉다운(knock-down) 방법으로서 또는, 유전자치료(gene therapy)의 방법으로 제공된다.As used in the present invention, the term “siRNA (small interfering RNA)” refers to short double chain RNA capable of inducing RNA interference (RNAi) phenomenon through cleavage of a specific mRNA. It consists of a sense RNA strand having a sequence homologous to the mRNA of the target gene and an antisense RNA strand having a sequence complementary thereto. Since siRNA can suppress the expression of the target gene, it is provided as an efficient gene knock-down method or as a method of gene therapy.

본 발명에서 용어 “shRNA(small hairpin RNA)”란 단일 가닥으로 50-60개로 구성된 뉴클레오타이드를 의미하며, in vivo상에서 스템-루프(stem-loop) 구조를 이루고 있다. 즉, shRNA는 RNA 간섭을 통해 유전자 발현을 억제하기 위한 타이트한 헤어핀 구조를 만드는 RNA 서열이다. 5-10개의 뉴클레오타이드의 루프 부위 양쪽으로 상보적으로 15-30개의 뉴클레오타이드의 긴 RNA가 염기쌍을 이루어 이중가닥의 스템을 형성한다. shRNA는 언제나 발현되도록 하기 위하여 U6 프로모터를 포함하는 벡터를 통해 세포 내로 실시예 1-5와 같이 형질주입되며 대개 딸세포로 전달되어 유전자 발현억제가 유전되도록 한다. shRNA 헤어핀 구조는 세포 내 기작에 의하여 절단되어 siRNA가 된 후 RISC(RNA-induced silencing complex)에 결합한다. 이들 RISC는 mRNA에 결합하여 이를 절단한다. shRNA는 RNA 폴리머레이즈(polymerase)에 의해 전사된다.In the present invention, the term “small hairpin RNA” (shRNA) means a nucleotide composed of 50-60 strands on a single strand, and forms a stem-loop structure in vivo. That is, shRNA is an RNA sequence that creates a tight hairpin structure for suppressing gene expression through RNA interference. The long RNAs of 15-30 nucleotides complementary to either side of the loop region of 5-10 nucleotides base-pair to form a double-stranded stem. The shRNA is transfected into a cell through a vector containing a U6 promoter as in Example 1-5 to be always expressed, and is usually delivered to a daughter cell so that gene expression suppression is inherited. The shRNA hairpin structure is cut by an intracellular mechanism to become an siRNA and then binds to an RNA-induced silencing complex (RISC). These RISCs bind and cleave the mRNA. shRNA is transcribed by RNA polymerase.

본 발명에 있어서, 유전자의 발현량을 측정하는 단계는 상처 치유 관련 유전자의 발현에 의해 생성된 RNA 또는 단백질의 양을 측정할 수 있는 당업계에 공지된 다양한 방법을 통해 실시될 수 있다. 바람직하게 RNA의 발현량은 중합효소연쇄반응(PCR), 마이크로어레이(microarray), 노던 블롯팅(northern blotting) 등을 통해 측정할 수 있고, 단백질의 발현량은 웨스턴 블롯팅(western blotting), 효소면역분석법(ELISA), 면역침강법(immunoprecipitation), 면역화학염색법(immunohistochemistry), 또는 면역형광염색법(immunofluorescence) 등을 통해 측정할 수 있으며, 당업자에 의해 매우 간단하고 용이하게 실시될 수 있으나, 이것으로 제한되는 것은 아니다.In the present invention, the step of measuring the expression level of the gene may be performed through various methods known in the art that can measure the amount of RNA or protein produced by expression of a wound healing related gene. Preferably, the expression level of RNA can be measured through polymerase chain reaction (PCR), microarray, northern blotting, etc., and the expression level of protein is western blotting, enzyme It can be measured by immunoassay (ELISA), immunoprecipitation (immunoprecipitation), immunochemical staining (immunohistochemistry), or immunofluorescence staining (immunofluorescence), etc., and can be carried out very simply and easily by those skilled in the art. It is not limited.

또한, 본 발명은 상기 92개의 단백질들로 이루어진 군으로부터 선택되는 하나 이상의 단백질을 유효성분으로 포함하는 상처 치료용 약학적 조성물을 제공한다.In addition, the present invention provides a pharmaceutical composition for wound treatment comprising at least one protein selected from the group consisting of 92 proteins as an active ingredient.

본 발명에 있어서, 상기 단백질은 바람직하게는 VISFATIN또는 STC1 단백질일 수 있으나, 이에 제한되지 않는다. 또한, 상기 상처 치료용 약학적 조성물은 ERK(extracelluar signal-regulated kinases) 및 JNK(c-jun N-termial kinases)의 활성화를 유도해서 혈관내피성장인자(Vascular endothelial growth factor; VEGF)의 발현을 증가시킬 수 있으나 이에 제한되지 않는다.In the present invention, the protein is preferably VISFATIN or STC1 protein, but is not limited thereto. In addition, the pharmaceutical composition for treating wounds induces activation of extracelluar signal-regulated kinases (ERK) and c-jun N-termial kinases (JNK), thereby increasing the expression of Vascular endothelial growth factor (VEGF). You can, but are not limited to this.

본 발명에서 사용되는 용어, “치료”란 상처 발병 후에 본 발명에 따른 약학적 조성물의 투여에 의해 상처에 대한 증세가 호전되거나 이롭게 변경되는 모든 행위를 의미한다.As used in the present invention, the term “treatment” refers to all actions in which symptoms of wounds are improved or beneficially changed by the administration of the pharmaceutical composition according to the present invention after wound development.

이에, 약학적 조성물로 제조하기 위하여 통상적으로 사용하는 적절한 담체, 부형제, 및 희석제를 더 포함할 수 있다. 또한 통상의 방법에 따라 산제, 과립제, 정제, 캡슐제, 현탁액, 에멀젼, 시럽, 에어로졸 등의 경구형 제형, 외용제, 좌제, 및 멸균 주사용액의 형태로 제형화하여 사용될 수 있다.Thus, suitable carriers, excipients, and diluents commonly used to prepare pharmaceutical compositions may be further included. In addition, it can be formulated and used in the form of oral dosage forms such as powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, external preparations, suppositories, and sterile injectable solutions according to a conventional method.

상기 조성물에 포함될 수 있는 담체, 부형제, 및 희석제로는 락토오스, 덱스트로오스, 수크로오스, 소르비톨, 만니톨, 자일리톨, 에리스리톨, 말티톨, 전분, 아카시아 고무, 알지네이트, 젤라틴, 칼슘 포스페이트, 칼슘 실리케이트, 셀룰로오스, 메틸 셀룰로오스, 미정질 셀룰로오스, 폴리비닐 피롤리돈, 물, 메틸히드록시 벤조에이트, 프로필히드록시 벤조에이트, 탈크, 마그네슘 스테아레이트, 및 광물유 등이 있다. 상기 조성물을 제제화할 경우에는 보통 사용하는 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 또는 부형제를 사용하여 조제된다.Carriers, excipients, and diluents that may be included in the composition include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl Cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxy benzoate, propylhydroxy benzoate, talc, magnesium stearate, and mineral oil. When formulating the composition, it is usually prepared using diluents or excipients, such as fillers, extenders, binders, wetting agents, disintegrating agents, surfactants.

본 발명에 따른 약학적 조성물은 약학적으로 유효한 양으로 투여한다. 본 발명에 있어서, "약학적으로 유효한 양"은 의학적 치료에 적용 가능한 합리적인 수혜/위험 비율로 질환을 치료하기에 충분한 양을 의미하며, 유효용량 수준은 환자의 질환의 종류, 중증도, 약물의 활성, 약물에 대한 민감도, 투여 시간, 투여 경로 및 배출 비율, 치료기간, 동시 사용되는 약물을 포함한 요소, 및 기타 의학 분야에 잘 알려진 요소에 따라 결정될 수 있다.The pharmaceutical composition according to the present invention is administered in a pharmaceutically effective amount. In the present invention, "a pharmaceutically effective amount" means an amount sufficient to treat a disease at a reasonable benefit/risk ratio applicable to medical treatment, and the effective dose level is the type of patient's disease, severity, and activity of the drug , Sensitivity to drug, time of administration, route of administration and rate of excretion, duration of treatment, factors including co-drugs used, and other factors well known in the medical field.

본 발명에 따른 약학적 조성물은 치료효과를 증진시키기 위하여, 바람직하게는 병용되는 약물과 동시에(simultaneous), 별도로(separate), 또는 순차적(sequential)으로 투여될 수 있으며, 단일 또는 다중 투여될 수 있다. 상기한 요소들을 모두 고려하여 부작용 없이 최소한의 양으로 최대 효과를 얻을 수 있는 양을 투여하는 것이 중요하며, 이는 당업자에 의해 용이하게 결정될 수 있다. 구체적으로, 본 발명에 따른 약학적 조성물의 유효량은 환자의 연령, 성별, 상태, 체중, 체내에서 활성 성분의 흡수도, 불활성율 및 배설속도, 질병종류, 병용되는 약물에 따라 달라질 수 있다.The pharmaceutical composition according to the present invention, in order to enhance the therapeutic effect, preferably can be administered concurrently (simultaneous), separately (separate), or sequentially (sequential) with the drugs used in combination, can be administered in a single or multiple . Considering all of the above factors, it is important to administer an amount that can achieve the maximum effect in a minimal amount without side effects, which can be easily determined by those skilled in the art. Specifically, the effective amount of the pharmaceutical composition according to the present invention may vary depending on the patient's age, sex, condition, weight, absorption of active ingredients in the body, inactivation rate and excretion rate, disease type, and drugs used in combination.

본 발명의 약학적 조성물은 개체에게 다양한 경로로 투여될 수 있다. 투여의 모든 방식은 예상될 수 있는데, 예를 들면, 경구 투여, 비강 내 투여, 경기관지 투여, 동맥 주사, 정맥 주사, 피하 주사, 근육 주사, 또는 복강 내 주사에 의해 투여될 수 있다. 일일 투여량은 하루 일회 내지 수회 나누어 투여하는 것이 바람직하나, 이에 제한되는 아니다.The pharmaceutical composition of the present invention can be administered to a subject by various routes. All modes of administration can be expected, for example, oral administration, intranasal administration, bronchoscopy, arterial injection, intravenous injection, subcutaneous injection, intramuscular injection, or intraperitoneal injection. The daily dosage is preferably divided into once to several times a day, but is not limited thereto.

본 발명의 약학적 조성물은 치료할 질환, 투여 경로, 환자의 연령, 성별, 체중, 및 질환의 중등도 등의 여러 관련 인자와 함께, 활성성분인 약물의 종류에 따라 결정된다. The pharmaceutical composition of the present invention is determined according to the type of drug as the active ingredient, along with various related factors such as the disease to be treated, the route of administration, the patient's age, sex, weight, and severity of the disease.

본 발명의 다른 양태로서, 본 발명은 상기 약학적 조성물을 개체에 투여하는 단계를 포함하는 상처 치료 방법을 제공한다. 본 발명에서 "개체"란 질병의 치료를 필요로 하는 대상을 의미하고, 보다 구체적으로는, 인간 또는 비-인간인 영장류, 생쥐(mouse), 개, 고양이, 말, 및 소 등의 포유류를 의미한다.In another aspect of the present invention, the present invention provides a method of treating a wound comprising administering the pharmaceutical composition to a subject. In the present invention, "individual" means a subject in need of treatment of a disease, and more specifically, a human or non-human primate, a mouse, a mammal such as a dog, cat, horse, and cow. do.

이하, 본 발명의 이해를 돕기 위하여 바람직한 실시예를 제시한다. 그러나 하기의 실시예는 본 발명을 보다 쉽게 이해하기 위하여 제공되는 것일 뿐, 하기 실시예에 의해 본 발명의 내용이 한정되는 것은 아니다.Hereinafter, preferred embodiments are provided to help understanding of the present invention. However, the following examples are only provided to more easily understand the present invention, and the contents of the present invention are not limited by the following examples.

[실시예][Example]

실시예 1. 물질 및 방법Example 1. Materials and methods

1-1. 피부 섬유아세포 배양1-1. Skin fibroblast culture

인간 피부 섬유아세포를 F12K와 DMEM 배지에 3:1로 섞고, 10% FBS, 100U/ml 페니실린(penicillin), 0.1mg/ml 스트렙토미신(streptomycin)을 첨가한 배지를 이용하여 배양하였다.Human skin fibroblasts were mixed with F12K and DMEM medium at a 3:1 ratio, and cultured using a medium containing 10% FBS, 100 U/ml penicillin, and 0.1 mg/ml streptomycin.

1-2. cDNA 마이크로어레이를 위한 섬유아세포에 표피생장인자 처리 및 mRNA 분리1-2. Epidermal growth factor treatment and mRNA isolation in fibroblasts for cDNA microarray

피부 섬유아세포는 6-웰 플레이트에서 2×105 cells/well씩 24시간 배양되었다. 24시간 배양 후 10% FBS를 첨가하지 않은 배지를 사용하여 배양하였다. 음성대조군으로 배지만 첨가된 것을 사용하였고, 실험군에는 1, 10, 50ng/mL 농도로 12시간 배양하였다. 배양된 피부 섬유아세포로부터 RNA를 분리하였다. Skin fibroblasts were cultured in 6-well plates at 2×10 5 cells/well for 24 hours. After incubation for 24 hours, culture was performed using a medium without 10% FBS. As a negative control, only medium added was used, and in the experimental group, cultured at concentrations of 1, 10 and 50 ng/mL for 12 hours. RNA was isolated from cultured skin fibroblasts.

1-3. cDNA 마이크로어레이 실시 및 실시간 정량 유전자 중합반응 어레이 (Real-time quantitative PCR array) 키트 제작1-3. cDNA microarray implementation and real-time quantitative PCR array kit production

분리된 총 500ng의 RNA(GeneChip WT PLUS reagent kit, Carlsbad, California, USA)를 사용하여 단편 DNA(ss-DNA)을 합성하였다. 총 3.5μg의 단편 DNA를 cDNA 마이크로어레이를 실시하였다. Affymetrix 기본 분석 설정 및 전역 배율을 사용하여 테이터를 분석하였다. 유전자 발현 폴드 변화는 배지만을 첨가한 대조군에 비해 200% 이상 증가한 2배 상향 조절 유전자와 50% 미만인 2배 미만의 하향 조절 유전자를 존재해야 한다는 요건을 포함한다. 분석된 유전자 중 92개의 유전자를 선별 및 발굴하였다. 발굴된 92개의 유전자를 이용하여 실시간 정량 유전자 중합반응 어레이키트를 제작하기 위해 프라이머를 디자인하였다. 96-웰에 디자인된 프라이머를 첨가하고 합성된 cDNA, 급속 사이버그린 텍폴리머레이즈를 첨가하여 실시간 정량 유전자 중합반응 어레이 키트를 제작하였다. Fragmented DNA (ss-DNA) was synthesized using 500 ng of total isolated RNA (GeneChip WT PLUS reagent kit, Carlsbad, California, USA). A total of 3.5 μg of fragment DNA was subjected to cDNA microarray. Data were analyzed using the Affymetrix basic analysis setup and global magnification. Gene expression fold changes include the requirement to have a 2-fold up-regulation gene that is increased by 200% or more and a 2-fold down-regulation gene that is less than 50% compared to the control group with only medium added. Among the analyzed genes, 92 genes were selected and excavated. Primers were designed to produce real-time quantitative gene polymerization reaction array kits using the 92 genes discovered. Real-time quantitative gene polymerization array kits were prepared by adding the designed primers to 96-wells and adding the synthesized cDNA and rapid cybergine tecpolymerase.

1-4. 피부 섬유아세포 증식 측정1-4. Measurement of skin fibroblast proliferation

96-웰 플레이트에 2×104 cells/well씩, 24 시간 동안 배양한 후, 16시간 동안 10% FBS (혈청)이 첨가하지 않은 배지에 배양하였다. 발굴된 92개의 유전자중 2개의 유전자를 선택하고 단백질을 확보하였다. 확보된 단백질을 피부 섬유아세포에 처리하였다. 음성대조군으로 배지만 첨가된 것, 양성대조군으로 표피생장인자 EGF 처리군이 사용되었으며, 실험군에는 1, 10, 50ng/mL의 농도로 VISFATIN 또는 STC1단백질이 24 시간 동안 처리되었다. 피부 섬유아세포의 증식 정도는 DNA에 표지된 BrdU 양이 증가하는 것을 플레이트 리더로 흡광도를 측정하여 확인하였다.2×10 4 cells/well were cultured in 96-well plates for 24 hours, followed by culture in a medium without 10% FBS (serum) for 16 hours. Two genes were selected from 92 genes and proteins were obtained. The obtained protein was treated with skin fibroblasts. As a negative control, only medium was added, and as a positive control, the epidermal growth factor EGF-treated group was used, and the experimental group was treated with VISFATIN or STC1 protein at a concentration of 1, 10, 50 ng/mL for 24 hours. The degree of proliferation of skin fibroblasts was confirmed by measuring the absorbance with a plate reader to increase the amount of BrdU labeled on the DNA.

1-5. 피부섬유아세포 이동능 측정1-5. Measurement of skin fibroblast mobility

12-웰 플레이트에 1×105 cells/well씩 24 시간 동안 배양한 후, 16시간 동안 10% FBS (혈청)이 첨가하지 않은 배지에 배양하였다. VISFATIN이나 STC1 단백질을 처리하기 전에 200μL의 팁을 이용하여 각각의 웰을 스크래치를 하였다. 확보된 단백질을 피부 섬유아세포에 처리하였다. 음성대조군으로 배지만 첨가된 것, 양성대조군으로 표피생장인자 EGF 처리군이 사용되었으며, 실험군에는 1, 10, 50ng/mL의 농도로 VISFATIN 또는 STC1 단백질이 24 시간 동안 처리되었다. VISFATIN과STC1 단백질에 의해 증가된 피부 섬유아세포의 이동능력은 로다민 팔로이딘(적색, Rhodamine phalloidin)으로 표지 되었으며, 현미경으로 관찰되었으며 사진을 찍어 스크래치된 부분의 면적을 분석해서 이동능력을 확인하였다.After incubating for 24 hours at 1×10 5 cells/well in a 12-well plate, the cells were cultured in a medium without 10% FBS (serum) for 16 hours. Each well was scratched with a 200 μL tip prior to treatment with VISFATIN or STC1 protein. The obtained protein was treated with skin fibroblasts. As a negative control, only medium was added, and as a positive control, the epidermal growth factor EGF-treated group was used. In the experimental group, VISFATIN or STC1 protein was treated at a concentration of 1, 10, 50 ng/mL for 24 hours. Skin fibroblast migration capacity increased by VISFATIN and STC1 proteins was labeled with rhodamine phalloidin (red, Rhodamine phalloidin), observed under a microscope, and photographed to analyze the area of the scratched area to confirm mobility.

1-6. 급성창상 마우스 모델에서 상처 치유능력 측정1-6. Wound healing ability measurement in acute wound mouse model

Pluronic ® 127을 saline에 22% (w/v)가 되도록 4℃에서 밤새도록 교반하여 녹인다. 이렇게 해서 하이드로젤을 만들어 4℃에서 보관한다. 하이드로젤은 실온에서 굳고 4℃이하에서는 젤의 형태를 유지하게 된다. VISFATIN 과 STC1 단백질을1μg/상처/25μL가 되도록 하이드로젤 형태로 준비하고 하이드로젤의 최종농도는 20%가 되도록 한다. 급성창상 마우스 모델에서 상처 치유능력을 측정하기 위해서 마우스 등 부분의 털을 제거한다. 마우스를 호흡마취를 통해 마취를 시킨 다음, 곧 바로 사진을 찍고 VISFATIN 단백질-하이드로젤 또는 STC1 단백질-하이드로젤 25μL를 상처에 처리한다. VISFATIN 단백질- 또는 STC1 단백질-하이드로젤은 1회/1일, 5일 동안 처리하도록 하고, 10일까지 관찰하고 사진을 찍어 확인한다. 이미지 J(Image J) 소프트웨어를 이용하여 상처 치료 정도를 분석하였다.Pluronic ® 127 is dissolved in saline by stirring overnight at 4° C. to 22% (w/v). In this way, a hydrogel is made and stored at 4°C. The hydrogel hardens at room temperature and maintains the shape of the gel below 4℃. The VISFATIN and STC1 proteins are prepared in a hydrogel form to be 1 μg/wound/25 μL, and the final concentration of the hydrogel is 20%. In the acute wound mouse model, the hair on the back of the mouse is removed to measure the wound healing ability. The mouse is anesthetized through respiratory anesthesia, and immediately after taking a picture, 25 μL of VISFATIN protein-hydrogel or STC1 protein-hydrogel is treated on the wound. The VISFATIN protein- or STC1 protein-hydrogel is treated for 1 time/ 1 day, 5 days, observed up to 10 days, and photographed to confirm. The extent of wound healing was analyzed using Image J software.

1-7. 급성창상 마우스 조직 분석1-7. Acute wound mouse tissue analysis

VISFATIN 단백질- 또는 STC1 단백질-하이드로젤을 처리한 후 6일 후에 마우스 피부 조직을 획득한다. 획득한 창상 조직은 고정, 파라핀고정, 조직 박편, 탈파라핀 과정을 거치고 헤마톡실린/에오신(H&E) 염색과 형광항체1/100 비율로 희석하여 실온에서 1시간동안 형광조직염색을 실시하였다. 염색된 조직 슬라이드는 OlympusIX 71를 이용하여 이미지화하였다. 이미지화한 조직은 이미지 J(Image J) 소프트웨어를 이용하여 분석하였다.Mouse skin tissues are obtained 6 days after treatment with VISFATIN protein- or STC1 protein-hydrogel. The obtained wound tissue was fixed, paraffin-fixed, tissue sliced, deparaffinized, diluted with hematoxylin/eosin (H&E) staining and a fluorescent antibody 1/100 ratio, and then stained with fluorescent tissue for 1 hour at room temperature. Stained tissue slides were imaged using OlympusIX 71. The imaged tissue was analyzed using Image J software.

1-8. 통계적 분석1-8. Statistical analysis

대조군과 실험군의 차이는 paired Student's t-test에 의해서 평가되었으며, P-values<0.05 인 경우 유의한 차이로 고려되었다.The difference between the control group and the experimental group was evaluated by paired Student's t- test, and was considered as a significant difference when P -values<0.05.

실시예 2. cDNA 마이크로어레이를 이용한 상처치료에 관련된 유전자의 발굴 및 실시간 정량 유전자 중합반응 어레이 키트 제작Example 2. Identification of genes related to wound treatment using cDNA microarrays and production of real-time quantitative gene polymerization reaction array kits

피부 섬유아세포는 6-웰 플레이트에서 2×105 cells/well씩, 24 시간 배양되었다. 24시간 배양 후 10% 혈청을 첨가하지 않은 배지를 사용하여 배양한다. 음성대조군으로 배지만 첨가된 것, 실험군에는 표피생성인자인 EGF를 1, 10, 50 ng/mL 농도로 12시간 배양하였다. 배양된 피부 섬유아세포로부터 RNA를 분리 한다.Skin fibroblasts were cultured in 6-well plates at 2×10 5 cells/well for 24 hours. After incubation for 24 hours, culture was performed using a medium without 10% serum. As a negative control group, only medium was added, and in the experimental group, EGF, an epidermal factor, was cultured at a concentration of 1, 10, 50 ng/mL for 12 hours. RNA is isolated from cultured skin fibroblasts.

분리된 총 500ng의 RNA(GeneChip WT PLUS reagent kit, Carlsbad, California, USA)를 사용하여 단편 DNA(ss-DNA)을 합성하였다. 총 3.5μg의 단편 DNA를 Affymetrix Human Gene ST 2.0 array에 Affymetrix hybridization system을 이용하여 혼성화한다. Fluidics 450을 이용하여 array를 세척하고 염색을 진행하였다. Affymetri scannder 3000 7G를 이용하여 결과를 획득하고 스캐닝을 통하여 얻어진 스팟의 신호강도를 수치화 테이터를 사용하여 RMA(Robust multi-array average) 평균화를 한다. 분석된 유전자 중 92개의 유전자를 선별 및 발굴하였다(도 1 참조). 발굴된 92개의 유전자를 이용하여 실시간 정량 유전자 중합반응 어레이키트를 제작하기 위해 프라이머를 하기 표1에 나타난 바와 같이 디자인하였다.Fragmented DNA (ss-DNA) was synthesized using 500 ng of total isolated RNA (GeneChip WT PLUS reagent kit, Carlsbad, California, USA). A total of 3.5 μg fragment DNA is hybridized to the Affymetrix Human Gene ST 2.0 array using the Affymetrix hybridization system. The array was washed and stained using Fluidics 450. The results are obtained using Affymetri scannder 3000 7G, and the signal intensity of the spots obtained through scanning is averaged using RMA (Robust multi-array average) using numerical data. Of the analyzed genes, 92 genes were selected and discovered (see FIG. 1). Primers were designed as shown in Table 1 below to produce a real-time quantitative gene polymerization array kit using 92 genes discovered.

NumberNumber Primer namePrimer name Forward sequence (5' --> 3')Forward sequence (5' --> 3') Reverse sequence (5' --> 3')Reverse sequence (5' --> 3') 1One hACTA2hACTA2 TAGCACCCAGCACCATGAAGTAGCACCCAGCACCATGAAG CTGCTGGAAGGTGGACAGAGCTGCTGGAAGGTGGACAGAG 22 hBMPERhBMPER AAGCATGGTGCTGTGTACGAAAGCATGGTGCTGTGTACGA CAAGTTTGCTGGACAGTGGCCAAGTTTGCTGGACAGTGGC 33 hCCL2hCCL2 ATCAATGCCCCAGTCACCTGATCAATGCCCCAGTCACCTG TCTCCTTGGCCACAATGGTCTCTCCTTGGCCACAATGGTC 44 hCH25HhCH25H ACATCTGGCTTTCCGTGGAGACATCTGGCTTTCCGTGGAG ACGGAGCGAAGTTGCAGTTAACGGAGCGAAGTTGCAGTTA 55 hCOL1A1hCOL1A1 CATGACCGAGACGTGTGGAACATGACCGAGACGTGTGGAA GGCAGTTCTTGGTCTCGTCAGGCAGTTCTTGGTCTCGTCA 66 hCOL1A2hCOL1A2 CTGCTGGAAGTCGTGGTGATCTGCTGGAAGTCGTGGTGAT ACGAAGCCCTTCTTTCCCAGACGAAGCCCTTCTTTCCCAG 77 hCOL3A1hCOL3A1 TGTTCCAGGAGCTAAAGGCGTGTTCCAGGAGCTAAAGGCG CTCCTGGGATGCCATTTGGTCTCCTGGGATGCCATTTGGT 88 hCOL4A1hCOL4A1 TTTTGTGATGCACACCAGCGTTTTGTGATGCACACCAGCG AGTAATTGCAGGTCCCACGGAGTAATTGCAGGTCCCACGG 99 hCOL5A1hCOL5A1 AGACATGGGCATCAAGGGTGAGACATGGGCATCAAGGGTG CCGAGTTTTCCCTTCTCCCCCCGAGTTTTCCCTTCTCCCC 1010 hCOL5A2hCOL5A2 GAGAACAAGGACCTCCAGGCGAGAACAAGGACCTCCAGGC TCTAGGTCCTAACGGGCCAATCTAGGTCCTAACGGGCCAA 1111 hCSF3hCSF3 CGGCCTTTTCCTCTACCAGGCGGCCTTTTCCTCTACCAGG GGCCATTCCCAGTTCTTCCAGGCCATTCCCAGTTCTTCCA 1212 hCTGFhCTGF GTTTGGCCCAGACCCAACTAGTTTGGCCCAGACCCAACTA GGCTCTGCTTCTCTAGCCTGGGCTCTGCTTCTCTAGCCTG 1313 hCTNNB1hCTNNB1 ATGATGGTCTGCCAAGTGGGATGATGGTCTGCCAAGTGGG GGCCATCTCTGCTTCTTGGTGGCCATCTCTGCTTCTTGGT 1414 hCTSKhCTSK GGGGGACATGACCAGTGAAGGGGGGACATGACCAGTGAAG CAGAGTCTGGGGCTCTACCTCAGAGTCTGGGGCTCTACCT 1515 hCXCL1hCXCL1 TGCAGGGAATTCACCCCAAGTGCAGGGAATTCACCCCAAG AGCTTTCCGCCCATTCTTGAAGCTTTCCGCCCATTCTTGA 1616 hCXCL5hCXCL5 TGTGTTGAGAGAGCTGCGTTTGTGTTGAGAGAGCTGCGTT CTTCCACCTTGGAGCACTGTCTTCCACCTTGGAGCACTGT 1717 hCXCL6hCXCL6 CTGTCTCTGCTGTGCTGACACTGTCTCTGCTGTGCTGACA CACTTCCACCTTGGAGCACTCACTTCCACCTTGGAGCACT 1818 hDUSP6hDUSP6 CGGAAATGGCGATCAGCAAGCGGAAATGGCGATCAGCAAG TGTGCGACGACTCGTATAGCTGTGCGACGACTCGTATAGC 1919 hEGFRhEGFR TTGCCGCAAAGTGTGTAACGTTGCCGCAAAGTGTGTAACG GAGATCGCCACTGATGGAGGGAGATCGCCACTGATGGAGG 2020 hEGR1hEGR1 GCTGGTGGAGACCAGTTACCGCTGGTGGAGACCAGTTACC CTGACCAAGCTGAAGAGGGGCTGACCAAGCTGAAGAGGGG 2121 hEMP1hEMP1 ATGCCAGTGAAGATGCCCTCATGCCAGTGAAGATGCCCTC GGTGAAGAGCTGGAACACGAGGTGAAGAGCTGGAACACGA 2222 hENO1hENO1 CTGCCTCCTGCTCAAAGTCACTGCCTCCTGCTCAAAGTCA AACCAGGTCAGCGATGAAGGAACCAGGTCAGCGATGAAGG 2323 hERRFI1hERRFI1 GACAGGCCTCCCAAAGTACCGACAGGCCTCCCAAAGTACC ACTTGGGATCAGGGGCAAAGACTTGGGATCAGGGGCAAAG 2424 hESM1hESM1 ACTTGCTACCGCACAGTCTCACTTGCTACCGCACAGTCTC CTGCAATCCATCCCGAAGGTCTGCAATCCATCCCGAAGGT 2525 hFGAhFGA CTGCCTGGTCCTAAGTGTGGCTGCCTGGTCCTAAGTGTGG GCAGAAGGGCCAGTCTGAATGCAGAAGGGCCAGTCTGAAT 2626 hFGF10hFGF10 GTGCGGAGCTACAATCACCTGTGCGGAGCTACAATCACCT ACGGGCAGTTCTCCTTCTTGACGGGCAGTTCTCCTTCTTG 2727 hFGF2hFGF2 AAAAACGGGGGCTTCTTCCTAAAAACGGGGGCTTCTTCCT AGCCAGGTAACGGTTAGCACAGCCAGGTAACGGTTAGCAC 2828 hFGF7hFGF7 TGGATCCTGCCAACTTTGCTTGGATCCTGCCAACTTTGCT TTCTTGTGTGTCGCTCAGGGTTCTTGTGTGTCGCTCAGGG 2929 hFOSL1hFOSL1 GCGGAGACTGACAAACTGGAGCGGAGACTGACAAACTGGA CTTGGCTCCTTCCGGGATTTCTTGGCTCCTTCCGGGATTT 3030 hFSThFST TGCTCTGCCAGTTCATGGAGTGCTCTGCCAGTTCATGGAG GCACTCCTCCTTGCTCAGTTGCACTCCTCCTTGCTCAGTT 3131 hHAS2hHAS2 TGACAGGCATCTCACGAACCTGACAGGCATCTCACGAACC GGGTCTGCTGGTTTAGCCATGGGTCTGCTGGTTTAGCCAT 3232 hHBEGFhHBEGF AGTCCGTGACTTGCAAGAGGAGTCCGTGACTTGCAAGAGG CCTCTTCTTCCCTAGCCCCTCCTCTTCTTCCCTAGCCCCT 3333 hHGFhHGF ACCCTGGTGTTTCACAAGCAACCCTGGTGTTTCACAAGCA TCCCAGCGCTGACAAATCTTTCCCAGCGCTGACAAATCTT 3434 hHMGA2hHMGA2 GCCCTCTCCTAAGAGACCCAGCCCTCTCCTAAGAGACCCA CTGCCTCTTGGCCGTTTTTCCTGCCTCTTGGCCGTTTTTC 3535 hICAM1hICAM1 CCAGGAGACACTGCAGACAGCCAGGAGACACTGCAGACAG CTTCACTGTCACCTCGGTCCCTTCACTGTCACCTCGGTCC 3636 hIER3hIER3 CCTGATGGCTGAAGAGGGTGCCTGATGGCTGAAGAGGGTG ATTAAAGGGCTCGAGGACGGATTAAAGGGCTCGAGGACGG 3737 hIL-13RA2hIL-13RA2 ATGCTGGGAAGGTGAAGACCATGCTGGGAAGGTGAAGACC GGCTTACGCAAAAGCAGACCGGCTTACGCAAAAGCAGACC 3838 hIL-33hIL-33 TCAGGTGACGGTGTTGATGGTCAGGTGACGGTGTTGATGG GGAGCTCCACAGAGTGTTCCGGAGCTCCACAGAGTGTTCC 3939 hIL1BhIL1B CCACCTCCAGGGACAGGATACCACCTCCAGGGACAGGATA AACACGCAGGACAGGTACAGAACACGCAGGACAGGTACAG 4040 hIL6hIL6 AGTGAGGAACAAGCCAGAGCAGTGAGGAACAAGCCAGAGC ATTTGTGGTTGGGTCAGGGGATTTGTGGTTGGGTCAGGGG 4141 hIL6SThIL6ST ACACAGCAGTGGTATTGGGGACACAGCAGTGGTATTGGGG ACTGGACAGTGCTCGAAGTGACTGGACAGTGCTCGAAGTG 4242 hIL7RhIL7R CCCTAGACTGCAGGGAGAGTCCCTAGACTGCAGGGAGAGT GGAGAGAAAATGGAGGGGGCGGAGAGAAAATGGAGGGGGC 4343 hIL8hIL8 CTCCAAACCTTTCCACCCCACTCCAAACCTTTCCACCCCA TTCCTTGGGGTCCAGACAGATTCCTTGGGGTCCAGACAGA 4444 hITGA1hITGA1 GGCAGCACAATTCATGCACAGGCAGCACAATTCATGCACA TGATCATCTTCCAGCGGAGCTGATCATCTTCCAGCGGAGC 4545 hITGA2hITGA2 CACAAAGACACAGGTGGGGTCACAAAGACACAGGTGGGGT TGGGATGTCTGGGATGTTGCTGGGATGTCTGGGATGTTGC 4646 hITGA3hITGA3 GGACATGTGGCTTGGAGTGAGGACATGTGGCTTGGAGTGA GCTGGTCTTCTGACCCTGACGCTGGTCTTCTGACCCTGAC 4747 hITGA4hITGA4 TGGAGCTTCTGTCTGTGCTGTGGAGCTTCTGTCTGTGCTG CTCCCGAGCCAGAGTTGATGCTCCCGAGCCAGAGTTGATG 4848 hITGA5hITGA5 ACATCTGTGTGCCTGACCTGACATCTGTGTGCCTGACCTG CTCACCCACATTCTGGGCATCTCACCCACATTCTGGGCAT 4949 hITGAVhITGAV TCCGATTCCAAACTGGGAGCTCCGATTCCAAACTGGGAGC AAGGCCACTGAAGATGGAGCAAGGCCACTGAAGATGGAGC 5050 hITGB1hITGB1 GTCGTGTGTGTGAGTGCAACGTCGTGTGTGTGAGTGCAAC AGACACCACACTCGCAGATGAGACACCACACTCGCAGATG 5151 hITGB3hITGB3 GCCCTGCTCATCTGGAAACTGCCCTGCTCATCTGGAAACT TTGGTGAAGGTAGACGTGGCTTGGTGAAGGTAGACGTGGC 5252 hITGB5hITGB5 CACCCAAAATGTGCCTGGTGCACCCAAAATGTGCCTGGTG TCAGGACATGGAAGCTGCTGTCAGGACATGGAAGCTGCTG 5353 hKRTAP1-5hKRTAP1-5 CAGACAGTCGTGTGGAGGGCAGACAGTCGTGTGGAGGG GCAGGACTGTCCACAGTAGGGCAGGACTGTCCACAGTAGG 5454 hLPXNhLPXN TGACTGAGATGCAGGCCAAGTGACTGAGATGCAGGCCAAG AGGTCCTGCAATTCCTGCTCAGGTCCTGCAATTCCTGCTC 5555 hMAPK1hMAPK1 ACCTACTGCCAGAGAACCCTACCTACTGCCAGAGAACCCT TCGATGGTTGGTGCTCGAATTCGATGGTTGGTGCTCGAAT 5656 hMAPK3hMAPK3 ACCACATTCTGGGCATCCTGACCACATTCTGGGCATCCTG CTTGGTCTTGGAGGGCAGAGCTTGGTCTTGGAGGGCAGAG 5757 hMCL1　hMCL1 GAGGAGGAGGAGGACGAGTTGAGGAGGAGGAGGACGAGTT CTGCCCATTGGCTTTGTGTCCTGCCCATTGGCTTTGTGTC 5858 hMIFhMIF CAGAACCGCTCCTACAGCAACAGAACCGCTCCTACAGCAA AAGGTGGAGTTGTTCCAGCCAAGGTGGAGTTGTTCCAGCC 5959 hMMP1hMMP1 AGTGGCCCAGTGGTTGAAAAAGTGGCCCAGTGGTTGAAAA CCACATCAGGCACTCCACATCCACATCAGGCACTCCACAT 6060 hMMP2hMMP2 CCCTGTGTCTTCCCCTTCACCCCTGTGTCTTCCCCTTCAC ATCGTAGTTGGCTGTGGTCGATCGTAGTTGGCTGTGGTCG 6161 hMMP3hMMP3 CACAGACCTGACTCGGTTCCCACAGACCTGACTCGGTTCC AGGTTCTGGAGGGACAGGTTAGGTTCTGGAGGGACAGGTT 6262 hVISFATINhVISFATIN TCGGTTCTGGTGGAGGTTTGTCGGTTCTGGTGGAGGTTTG TTGGGATCAGCAACTGGGTCTTGGGATCAGCAACTGGGTC 6363 hNPAS2hNPAS2 ATCCTGCAGGCCAATATCCGATCCTGCAGGCCAATATCCG CTGCTGCAGGAACATCTGGACTGCTGCAGGAACATCTGGA 6464 hPDGFAhPDGFA GGCCAAGGTGGAATACGTCAGGCCAAGGTGGAATACGTCA ATCCGGATTCAGGCTTGTGGATCCGGATTCAGGCTTGTGG 6565 hPLAThPLAT TACAGCCAGCCTCAGTTTCGTACAGCCAGCCTCAGTTTCG GAGCTGATGAGTATGCCCCCGAGCTGATGAGTATGCCCCC 6666 hPLAUhPLAU CCAAAATGCTGTGTGCTGCTCCAAAATGCTGTGTGCTGCT TTGTCCTTCAGGGCACATCCTTGTCCTTCAGGGCACATCC 6767 hPLAURhPLAUR GGCTTGAAGATCACCAGCCTGGCTTGAAGATCACCAGCCT TGCATTCGAGGTAACGGCTTTGCATTCGAGGTAACGGCTT 6868 hPLGhPLG CTACCCAAATGCTGGCCTGACTACCCAAATGCTGGCCTGA ACTCGCTTCTGTTCCTGAGCACTCGCTTCTGTTCCTGAGC 6969 hPTENhPTEN TGTGGTCTGCCAGCTAAAGGTGTGGTCTGCCAGCTAAAGG ACACACAGGTAACGGCTGAGACACACAGGTAACGGCTGAG 7070 hPTGS2hPTGS2 GTTCCACCCGCAGTACAGAAGTTCCACCCGCAGTACAGAA AGGGCTTCAGCATAAAGCGTAGGGCTTCAGCATAAAGCGT 7171 hPTX3hPTX3 CCTGCATTTGGGTCAAAGCCCCTGCATTTGGGTCAAAGCC CTCCACCCACCACAAACACTCTCCACCCACCACAAACACT 7272 hRAC1hRAC1 CATCACCTATCCGCAGGGTCCATCACCTATCCGCAGGGTC TCGGATCGCTTCGTCAAACATCGGATCGCTTCGTCAAACA 7373 hRHOAhRHOA GGTGATGGAGCCTGTGGAAAGGTGATGGAGCCTGTGGAAA TGTGTCCCACAAAGCCAACTTGTGTCCCACAAAGCCAACT 7474 hSERPINB2hSERPINB2 GCTGGCACAGGAGGTGTTATGCTGGCACAGGAGGTGTTAT AGGGTGAGGAAAATCTGCCGAGGGTGAGGAAAATCTGCCG 7575 hSERPINE 1hSERPINE 1 GGGCCATGGAACAAGGATGAGGGCCATGGAACAAGGATGA CCGGAACAGCCTGAAGAAGTCCGGAACAGCCTGAAGAAGT 7676 hSERPINE2hSERPINE2 AAGAAACGCACTTTCGTGGCAAGAAACGCACTTTCGTGGC CCGTGGTAGGGCAGTTCAATCCGTGGTAGGGCAGTTCAAT 7777 hSLC20A1hSLC20A1 GCAACTCGTGGCTTCGTTTTGCAACTCGTGGCTTCGTTTT GACCACTTGACACCCTCCTGGACCACTTGACACCCTCCTG 7878 hSLIT2hSLIT2 AAGCTTCAGACCATCGCCAAAAGCTTCAGACCATCGCCAA AGCCACTTGAGATGGCAGTCAGCCACTTGAGATGGCAGTC 7979 hSMURF2hSMURF2 AGATCCTCGGCTGTCTGCTAAGATCCTCGGCTGTCTGCTA CTGAACCAGGTCTCGCTTGTCTGAACCAGGTCTCGCTTGT 8080 hSTAT3hSTAT3 CTGTGGGAAGAATCACGCCTCTGTGGGAAGAATCACGCCT ACATCCTGAAGGTGCTGCTCACATCCTGAAGGTGCTGCTC 8181 hSTC1hSTC1 TTGCTGAGGTGCAGGAAGAGTTGCTGAGGTGCAGGAAGAG CAGGCTTCGGACAAGTCTGTCAGGCTTCGGACAAGTCTGT 8282 hSDC4hSDC4 CCCTCCACTTGGAAGGACACCCCTCCACTTGGAAGGACAC CAGGACTACAGCCTCTCCCTCAGGACTACAGCCTCTCCCT 8383 hTAGLNhTAGLN AGGTCTGGCTGAAGAATGGCAGGTCTGGCTGAAGAATGGC CACCTGCTCCATCTGCTTGACACCTGCTCCATCTGCTTGA 8484 hTFPI2hTFPI2 CTGTCTCCTGCCCCTAGACTCTGTCTCCTGCCCCTAGACT AAATTGTTGGCGTTGCCCTCAAATTGTTGGCGTTGCCCTC 8585 hTGFB1hTGFB1 TGGTGGAAACCCACAACGAATGGTGGAAACCCACAACGAA GAGCAACACGGGTTCAGGTAGAGCAACACGGGTTCAGGTA 8686 hTGFBR3hTGFBR3 CCTCAGTCCACATCCACCACCCTCAGTCCACATCCACCAC CCACAGAACCCTCAGACACCCCACAGAACCCTCAGACACC 8787 hTIMP1hTIMP1 GGGGCTTCACCAAGACCTACGGGGCTTCACCAAGACCTAC GGAAGCCCTTTTCAGAGCCTGGAAGCCCTTTTCAGAGCCT 8888 hTMEM158hTMEM158 CTGCTGCCTAGACTTCAGCCCTGCTGCCTAGACTTCAGCC CTCCACACCACGATGACCAGCTCCACACCACGATGACCAG 8989 hTNFAIP6hTNFAIP6 AGCACGGTCTGGCAAATACAAGCACGGTCTGGCAAATACA ATCCATCCAGCAGCACAGACATCCATCCAGCAGCACAGAC 9090 hVEGFAhVEGFA CTTGCCTTGCTGCTCTACCTCTTGCCTTGCTGCTCTACCT GCAGTAGCTGCGCTGATAGAGCAGTAGCTGCGCTGATAGA 9191 hWNT5AhWNT5A CGCGAAGACAGGCATCAAAGCGCGAAGACAGGCATCAAAG ATCTGCATCACCCTGCCAAAATCTGCATCACCCTGCCAAA 9292 hGAPDHhGAPDH TCCTGCACCACCAACTGTTTTCCTGCACCACCAACTGTTT GTCCACTGTCTTCTGGGTGGGTCCACTGTCTTCTGGGTGG

실시예 3. 발굴된 92개의 유전자 중 2개의 유전자인 VISFATIN과 STC1의 세포증식 효과 확인Example 3. Confirmation of cell proliferation effect of VISFATIN and STC1, two of 92 genes discovered

cDNA 마이크로어레이를 통해 발굴된 92개의 유전자 중 2개의 유전자인 VISFATIN과 STC1을 선택해 단백질을 확보하여 피부 섬유아세포의 세포 증식 효과가 있는지를 BrdU 어세이를 통해 확인하였다. 배지만 첨가한 음성대조군, VISFATIN 또는 STC1을 1, 10, 50, 100ng/mL의 농도로 24 시간 처리한 실험군, 표피생장인자인 EGF를 1, 10, 50, 100 ng/mL의 농도로 24 시간 처리한 양성대조군의 피부 섬유아세포의 세포 증식을 확인한 결과, 도 2a 및 2b에 나타난 바와 같이, 양성대조군인 표피생장인자를 처리한 세포 증식 결과와 VISFATIN 단백질과 STC1 단백질을 처리한 실험군의 세포 증식 효과가 유의하게 나타남을 확인하였다(3회 반복시험 결과, *P<0.01, 배지만 첨가한 음성대조군에 대하여). 즉, cDNA 마이크로어레이를 통해 발굴한 유전자인 VISFATIN 단백질과 STC1 단백질이 상처치료에 중요한 역할을 하는 세포 증식을 증가시킴을 확인할 수 있었다. Of the 92 genes discovered through the cDNA microarray, two genes, VISFATIN and STC1, were selected to obtain proteins, and the cell proliferation effect of skin fibroblasts was confirmed by BrdU assay. Negative control with medium added, VISFATIN or STC1 treated at a concentration of 1, 10, 50, and 100 ng/mL for 24 hours, and EGF, an epidermal growth factor, treated for 24 hours at a concentration of 1, 10, 50, 100 ng/mL As a result of confirming the cell proliferation of skin fibroblasts of one positive control group, as shown in FIGS. 2A and 2B, the cell proliferation effect of the epidermal growth factor, which is a positive control group, and the cell proliferation effect of the experimental group treated with VISFATIN protein and STC1 protein It was confirmed that it appeared significantly (3 repeated tests, * P <0.01, for the negative control with medium only). That is, it was confirmed that the genes discovered through the cDNA microarray, VISFATIN protein and STC1 protein, increase cell proliferation, which plays an important role in wound healing.

실시예 4. VISFATIN 단백질과 STC1 단백질의 세포 이동능력 증가를 확인Example 4. Confirmation of increased cell migration capacity of VISFATIN protein and STC1 protein

상처 치료에 중요한 단계 중의 하나인 세포 이동능을 VISFATIN 단백질과 STC1 단백질이 영향을 주는지 확인하기 위해서 스크래치 어세이를 실시하였다. 먼저, 12-웰 플레이트에 배양된 피부 섬유세포를 200μL 팀을 이용하여 균일하게 스크래치를 만든 후, 피부 섬유아세포를 배지만 처리한 음성대조군, VISFATIN 단백질 또는 STC1 단백질을 처리한 실험군, 표피생장인자를 처리한 양성실험군을 각각 1, 10, 50 ng/mL 처리하고 24시간 배양하였다. 세포는 4% paraformaldehyde로 고정시키고 난 후, 로다민 팔로이딘(Rhodamine phalliodin, 적색)을 PBS에 1/200으로 희석하여 실온에서 1시간 동안 염색하였다. 로다민 팔로이딘으로 염색된 세포는 OlympusIX 71를 이용하여 이미지화하였다. 이미지화한 조직은 이미지 J(Image J) 소프트웨어를 이용하여 분석하였다. 결과적으로 도 3a 및 3b에 나타난 바와 같이, VISFATIN 단백질 또는 STC1 단백질을 처리한 피부 섬유아세포의 세포 이동이 아무것도 처리하지 않은 세포에 비해 확연하게 증가함을 확인하였다 (3회 반복시험 결과, *P<0.01, **P<0.05, 미처리군에 대하여). Scratch assay was performed to confirm whether VISFATIN protein and STC1 protein influence cell migration ability, which is one of the important steps in wound healing. First, the skin fibroblasts cultured in a 12-well plate were uniformly scratched using a 200 μL team, and then treated with a negative control, VISFATIN protein, or STC1 protein treated with cultured skin fibroblasts, and epidermal growth factor. One positive experimental group was treated with 1, 10 and 50 ng/mL, respectively, and cultured for 24 hours. After fixing the cells with 4% paraformaldehyde, rhodamine phalliodin (red) was diluted 1/200 in PBS and stained for 1 hour at room temperature. Cells stained with rhodamine paloidine were imaged using OlympusIX 71. The imaged tissue was analyzed using Image J software. As a result, as shown in Figures 3a and 3b, it was confirmed that the cell migration of skin fibroblasts treated with VISFATIN protein or STC1 protein is significantly increased compared to the cells not treated with anything (3 results of repeated tests, * P < 0.01, ** P <0.05, for untreated group).

실시예 5.VISFATIN 단백질과 STC1 단백질의 마우스 급성창상에 대한 치유능력을 향상을 확인Example 5 Confirmation of improvement of healing ability against acute wound of mouse of VISFATIN protein and STC1 protein

마우스 동물 급성창상 모델에서 VISFATIN 단백질과 STC1 단백질의 상처치유 능력을 측정하였다. 1μg/25μL의 VISFATIN 단백질- 또는 STC1 단백질-하이드로젤을 마우스 급성창상에 1회/1일, 5일간 처리하였다. 음성대조군은 25μL의 saline-하이드로젤, 양성대조군은 25μL의 표피생장인자 EGF를 1회/1일, 5일간 처리하였다. 창상의 치유 변화는 매일 사진을 찍어 이미지 J(Image J) 소프트웨어를 이용하여 분석하였다. 그 결과, 도 4a 및 4b에 나타난 바와 같이, VISFATIN 단백질과 STC1 단백질을 처리한 실험군은 표피생장인자를 처리한 양성대조군과 유사하게 급성창상을 치유함을 확인할 수 있었다. The wound healing ability of VISFATIN protein and STC1 protein was measured in a mouse animal acute wound model. 1 μg/25 μL of VISFATIN protein- or STC1 protein-hydrogel was treated once a day, for 5 days in acute wounds of mice. The negative control was treated with 25 μL of saline-hydrogel, and the positive control was treated with 25 μL of epidermal growth factor EGF once/day for 5 days. The healing changes of wounds were taken daily and analyzed using Image J software. As a result, as shown in Figures 4a and 4b, it was confirmed that the experimental group treated with VISFATIN protein and STC1 protein healed acute wounds similarly to the positive control group treated with epidermal growth factor.

실시예 6. VISFATIN단백질에 의해 유도된 VEGF의 발현 증가가 상처치유 향상을 확인Example 6. Increased expression of VEGF induced by VISFATIN protein confirmed improvement in wound healing

VISFATIN 단백질과 STC1 단백질에 유도된 마우스 급성창상 모델에서 상처 치유를 향상시키는 원인을 확인하게 위해 saline-하이드로젤(음성대조군), 1μg/25μL의 VISFATIN 단백질-하이드로젤(실험군), 또는, 1μg/25μL의 표피생장인자 EGF(양성대조군)을 6일간 처리한 마우스 창상 조직을 획득하여, 조직 염색을 실시하였다. 조직염색으로는 헤마톡실린&에오신(H&E) 염색을 실시하였으며, 같은 조직의 같은 부위를 1차로 혈관내피성장인자(Vascular endothelial growth factor, VEGF) 항체로 반응시키고 2차로 마우스-형광 Alexa 488 항체로 반응시켜 조직 내 VEGF의 발현을 측정하였다. 그 결과, 도 5에 나타난 바와 같이, 혈관내피성장인자인 VEGF가 VISFATIN 단백질-하이드로젤을 처리한 마우스 창상조직에서 음성대조군에 비해 확연하게 증가함을 확인하였다. 또한, VEGF 발현이 양성대조군을 처리한 결과와 유사하게 증가함을 확인할 수 있었다(3회 반복시험 결과, *P<0.05, 미처리군에 대하여). 더불어, VEGF 발현증가의 분자적 메커니즘을 확인하기 위해 pERK와 pJNK의 1차 항체와 2차 마우스-형광 Alexa 488 항체로 조직을 형광 염색하였다. 그 결과, 도 6에 나타난 바와 같이, pERK와 pJNK의 활성화가 VISFATIN단백질-하이드로젤을 처리한 마우스 창상조직에서 음성대조군에 비해 확연하게 증가함을 확인하였다. 또한, ERK와 JNK의 활성화가 양성대조군을 처리한 결과와 유사하게 증가함을 확인할 수 있었다(3회 반복시험 결과, *P<0.05, 미처리군에 대하여). 즉, VISFATIN 단백질이 ERK와 JNK의 활성화를 유도해서 VEGF의 발현을 증가시키고 증가된 VEGF로 인해 상처 치유를 향상시킴을 확인 할 수 있었다.In the mouse acute wound model induced by VISFATIN protein and STC1 protein, saline-hydrogel (negative control), 1 μg/25 μL of VISFATIN protein-hydrogel (experiment), or 1 μg/25 μL The mouse wound tissue treated with the epidermal growth factor EGF (positive control) of 6 days was obtained, and tissue staining was performed. For tissue staining, hematoxylin & eosin (H&E) staining was performed, and the same site of the same tissue was first reacted with a Vascular endothelial growth factor (VEGF) antibody and secondly with mouse-fluorescent Alexa 488 antibody. In response, the expression of VEGF in the tissue was measured. As a result, as shown in FIG. 5, it was confirmed that VEGF, a vascular endothelial growth factor, was significantly increased in the wound tissue of the mouse treated with VISFATIN protein-hydrogel compared to the negative control. In addition, it was confirmed that VEGF expression increased similarly to the result of treatment with the positive control group (3 repetition test results, * P <0.05, for the untreated group). In addition, tissues were fluorescently stained with primary antibodies of pERK and pJNK and secondary mouse-fluorescent Alexa 488 antibodies to confirm the molecular mechanism of VEGF expression increase. As a result, as shown in Figure 6, it was confirmed that the activation of pERK and pJNK significantly increased compared to the negative control in the wound tissue of mice treated with VISFATIN protein-hydrogel. In addition, it was confirmed that the activation of ERK and JNK increased similarly to the result of treatment with the positive control group (3 repetition test results, * P <0.05, for the untreated group). That is, it was confirmed that the VISFATIN protein induces activation of ERK and JNK to increase the expression of VEGF and improve wound healing due to the increased VEGF.

전술한 본 발명의 설명은 예시를 위한 것이며, 본 발명이 속하는 기술분야의 통상의 지식을 가진 자는 본 발명의 기술적 사상이나 필수적인 특징을 변경하지 않고서 다름 구체적인 형태로 쉽게 변형이 가능하다는 것을 이해할 수 있을 것이다. 그러므로 이상에서 기술한 실시예들은 모든 면에서 예시적인 것이며 한정적인 아닌 것으로 이해해야 한다.The above description of the present invention is for illustration only, and those of ordinary skill in the art to which the present invention pertains can understand that it can be easily modified to other specific forms without changing the technical spirit or essential features of the present invention. will be. Therefore, it should be understood that the above-described embodiments are illustrative in all respects and not restrictive.

<110> Korea University Industry and Academy Cooperation Foundation <120> Composition for the screening of wound healing agent and screening method for the same <130> MP18-299 <160> 276 <170> KoPatentIn 3.0 <210> 1 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hACTA2 F <400> 1 tagcacccag caccatgaag 20 <210> 2 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hACTA2 R <400> 2 ctgctggaag gtggacagag 20 <210> 3 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hBMPER F <400> 3 aagcatggtg ctgtgtacga 20 <210> 4 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hBMPER R <400> 4 caagtttgct ggacagtggc 20 <210> 5 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCCL2 F <400> 5 atcaatgccc cagtcacctg 20 <210> 6 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCCL2 R <400> 6 tctccttggc cacaatggtc 20 <210> 7 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCH25H F <400> 7 acatctggct ttccgtggag 20 <210> 8 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCH25H R <400> 8 acggagcgaa gttgcagtta 20 <210> 9 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL1A1 F <400> 9 catgaccgag acgtgtggaa 20 <210> 10 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL1A1 R <400> 10 ggcagttctt ggtctcgtca 20 <210> 11 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL1A2 F <400> 11 ctgctggaag tcgtggtgat 20 <210> 12 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL1A2 R <400> 12 acgaagccct tctttcccag 20 <210> 13 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL3A1 F <400> 13 tgttccagga gctaaaggcg 20 <210> 14 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL3A1 R <400> 14 ctcctgggat gccatttggt 20 <210> 15 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL4A1 F <400> 15 ttttgtgatg cacaccagcg 20 <210> 16 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL4A1 R <400> 16 agtaattgca ggtcccacgg 20 <210> 17 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL5A1 F <400> 17 agacatgggc atcaagggtg 20 <210> 18 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL5A1 R <400> 18 ccgagttttc ccttctcccc 20 <210> 19 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL5A2 F <400> 19 gagaacaagg acctccaggc 20 <210> 20 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL5A2 R <400> 20 tctaggtcct aacgggccaa 20 <210> 21 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCSF3 F <400> 21 cggccttttc ctctaccagg 20 <210> 22 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCSF3 R <400> 22 ggccattccc agttcttcca 20 <210> 23 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCTGF F <400> 23 gtttggccca gacccaacta 20 <210> 24 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCTGF R <400> 24 ggctctgctt ctctagcctg 20 <210> 25 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCTNNB1 F <400> 25 atgatggtct gccaagtggg 20 <210> 26 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCTNNB1 R <400> 26 ggccatctct gcttcttggt 20 <210> 27 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCTSK F <400> 27 gggggacatg accagtgaag 20 <210> 28 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCTSK R <400> 28 cagagtctgg ggctctacct 20 <210> 29 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCXCL1 F <400> 29 tgcagggaat tcaccccaag 20 <210> 30 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCXCL1 R <400> 30 agctttccgc ccattcttga 20 <210> 31 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCXCL5 F <400> 31 tgtgttgaga gagctgcgtt 20 <210> 32 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCXCL5 R <400> 32 cttccacctt ggagcactgt 20 <210> 33 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCXCL6 F <400> 33 ctgtctctgc tgtgctgaca 20 <210> 34 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCXCL6 R <400> 34 cacttccacc ttggagcact 20 <210> 35 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hDUSP6 F <400> 35 cggaaatggc gatcagcaag 20 <210> 36 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hDUSP6 R <400> 36 tgtgcgacga ctcgtatagc 20 <210> 37 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hEGFR F <400> 37 ttgccgcaaa gtgtgtaacg 20 <210> 38 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hEGFR R <400> 38 gagatcgcca ctgatggagg 20 <210> 39 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hEGR1 F <400> 39 gctggtggag accagttacc 20 <210> 40 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hEGR1 R <400> 40 ctgaccaagc tgaagagggg 20 <210> 41 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hEMP1 F <400> 41 atgccagtga agatgccctc 20 <210> 42 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hEMP1 R <400> 42 ggtgaagagc tggaacacga 20 <210> 43 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hENO1 F <400> 43 ctgcctcctg ctcaaagtca 20 <210> 44 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hENO1 R <400> 44 aaccaggtca gcgatgaagg 20 <210> 45 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hERRFI1 F <400> 45 gacaggcctc ccaaagtacc 20 <210> 46 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hERRFI1 R <400> 46 acttgggatc aggggcaaag 20 <210> 47 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hESM1 F <400> 47 acttgctacc gcacagtctc 20 <210> 48 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hESM1 R <400> 48 ctgcaatcca tcccgaaggt 20 <210> 49 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGA F <400> 49 ctgcctggtc ctaagtgtgg 20 <210> 50 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGA R <400> 50 gcagaagggc cagtctgaat 20 <210> 51 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGF10 F <400> 51 gtgcggagct acaatcacct 20 <210> 52 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGF10 R <400> 52 acgggcagtt ctccttcttg 20 <210> 53 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGF2 F <400> 53 aaaaacgggg gcttcttcct 20 <210> 54 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGF2 R <400> 54 agccaggtaa cggttagcac 20 <210> 55 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGF7 F <400> 55 tggatcctgc caactttgct 20 <210> 56 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGF7 R <400> 56 ttcttgtgtg tcgctcaggg 20 <210> 57 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFOSL1 F <400> 57 gcggagactg acaaactgga 20 <210> 58 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFOSL1 R <400> 58 cttggctcct tccgggattt 20 <210> 59 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFST F <400> 59 tgctctgcca gttcatggag 20 <210> 60 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFST R <400> 60 gcactcctcc ttgctcagtt 20 <210> 61 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHAS2 F <400> 61 tgacaggcat ctcacgaacc 20 <210> 62 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHAS2 R <400> 62 gggtctgctg gtttagccat 20 <210> 63 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHBEGF F <400> 63 agtccgtgac ttgcaagagg 20 <210> 64 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHBEGF R <400> 64 cctcttcttc cctagcccct 20 <210> 65 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHGF F <400> 65 accctggtgt ttcacaagca 20 <210> 66 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHGF R <400> 66 tcccagcgct gacaaatctt 20 <210> 67 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHMGA2 F <400> 67 gccctctcct aagagaccca 20 <210> 68 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHMGA2 R <400> 68 ctgcctcttg gccgtttttc 20 <210> 69 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hICAM1 F <400> 69 ccaggagaca ctgcagacag 20 <210> 70 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hICAM1 R <400> 70 cttcactgtc acctcggtcc 20 <210> 71 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIER3 F <400> 71 cctgatggct gaagagggtg 20 <210> 72 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIER3 R <400> 72 attaaagggc tcgaggacgg 20 <210> 73 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL-13RA2 F <400> 73 atgctgggaa ggtgaagacc 20 <210> 74 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL-13RA2 R <400> 74 ggcttacgca aaagcagacc 20 <210> 75 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL-33 F <400> 75 tcaggtgacg gtgttgatgg 20 <210> 76 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL-33 R <400> 76 ggagctccac agagtgttcc 20 <210> 77 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL1B F <400> 77 ccacctccag ggacaggata 20 <210> 78 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL1B R <400> 78 aacacgcagg acaggtacag 20 <210> 79 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL6 F <400> 79 agtgaggaac aagccagagc 20 <210> 80 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL6 R <400> 80 atttgtggtt gggtcagggg 20 <210> 81 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL6ST F <400> 81 acacagcagt ggtattgggg 20 <210> 82 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL6ST R <400> 82 actggacagt gctcgaagtg 20 <210> 83 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL7R F <400> 83 ccctagactg cagggagagt 20 <210> 84 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL7R R <400> 84 ggagagaaaa tggagggggc 20 <210> 85 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL8 F <400> 85 ctccaaacct ttccacccca 20 <210> 86 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL8 R <400> 86 ttccttgggg tccagacaga 20 <210> 87 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA1 F <400> 87 ggcagcacaa ttcatgcaca 20 <210> 88 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA1 R <400> 88 tgatcatctt ccagcggagc 20 <210> 89 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA2 F <400> 89 cacaaagaca caggtggggt 20 <210> 90 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA2 R <400> 90 tgggatgtct gggatgttgc 20 <210> 91 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA3 F <400> 91 ggacatgtgg cttggagtga 20 <210> 92 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA3 R <400> 92 gctggtcttc tgaccctgac 20 <210> 93 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA4 F <400> 93 tggagcttct gtctgtgctg 20 <210> 94 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA4 R <400> 94 ctcccgagcc agagttgatg 20 <210> 95 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA5 F <400> 95 acatctgtgt gcctgacctg 20 <210> 96 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA5 R <400> 96 ctcacccaca ttctgggcat 20 <210> 97 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGAV F <400> 97 tccgattcca aactgggagc 20 <210> 98 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGAV R <400> 98 aaggccactg aagatggagc 20 <210> 99 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGB1 F <400> 99 gtcgtgtgtg tgagtgcaac 20 <210> 100 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGB1 R <400> 100 agacaccaca ctcgcagatg 20 <210> 101 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGB3 F <400> 101 gccctgctca tctggaaact 20 <210> 102 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGB3 R <400> 102 ttggtgaagg tagacgtggc 20 <210> 103 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGB5 F <400> 103 cacccaaaat gtgcctggtg 20 <210> 104 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGB5 R <400> 104 tcaggacatg gaagctgctg 20 <210> 105 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> hKRTAP1-5 F <400> 105 cagacagtcg tgtggaggg 19 <210> 106 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hKRTAP1-5 R <400> 106 gcaggactgt ccacagtagg 20 <210> 107 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hLPXN F <400> 107 tgactgagat gcaggccaag 20 <210> 108 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hLPXN R <400> 108 aggtcctgca attcctgctc 20 <210> 109 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMAPK1 F <400> 109 acctactgcc agagaaccct 20 <210> 110 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMAPK1 R <400> 110 tcgatggttg gtgctcgaat 20 <210> 111 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMAPK3 F <400> 111 accacattct gggcatcctg 20 <210> 112 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMAPK3 R <400> 112 cttggtcttg gagggcagag 20 <210> 113 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMCL1 F <400> 113 gaggaggagg aggacgagtt 20 <210> 114 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMCL1 R <400> 114 ctgcccattg gctttgtgtc 20 <210> 115 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMIF F <400> 115 cagaaccgct cctacagcaa 20 <210> 116 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMIF R <400> 116 aaggtggagt tgttccagcc 20 <210> 117 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMMP1 F <400> 117 agtggcccag tggttgaaaa 20 <210> 118 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMMP1 R <400> 118 ccacatcagg cactccacat 20 <210> 119 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMMP2 F <400> 119 ccctgtgtct tccccttcac 20 <210> 120 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMMP2 R <400> 120 atcgtagttg gctgtggtcg 20 <210> 121 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMMP3 F <400> 121 cacagacctg actcggttcc 20 <210> 122 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMMP3 R <400> 122 aggttctgga gggacaggtt 20 <210> 123 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hVISFATIN F <400> 123 tcggttctgg tggaggtttg 20 <210> 124 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hVISFATIN R <400> 124 ttgggatcag caactgggtc 20 <210> 125 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hNPAS2 F <400> 125 atcctgcagg ccaatatccg 20 <210> 126 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hNPAS2 R <400> 126 ctgctgcagg aacatctgga 20 <210> 127 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPDGFA F <400> 127 ggccaaggtg gaatacgtca 20 <210> 128 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPDGFA R <400> 128 atccggattc aggcttgtgg 20 <210> 129 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLAT F <400> 129 tacagccagc ctcagtttcg 20 <210> 130 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLAT R <400> 130 gagctgatga gtatgccccc 20 <210> 131 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLAU F <400> 131 ccaaaatgct gtgtgctgct 20 <210> 132 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLAU R <400> 132 ttgtccttca gggcacatcc 20 <210> 133 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLAUR F <400> 133 ggcttgaaga tcaccagcct 20 <210> 134 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLAUR R <400> 134 tgcattcgag gtaacggctt 20 <210> 135 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLG F <400> 135 ctacccaaat gctggcctga 20 <210> 136 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLG R <400> 136 actcgcttct gttcctgagc 20 <210> 137 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPTEN F <400> 137 tgtggtctgc cagctaaagg 20 <210> 138 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPTEN R <400> 138 acacacaggt aacggctgag 20 <210> 139 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPTGS2 F <400> 139 gttccacccg cagtacagaa 20 <210> 140 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPTGS2 R <400> 140 agggcttcag cataaagcgt 20 <210> 141 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPTX3 <400> 141 cctgcatttg ggtcaaagcc 20 <210> 142 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPTX3 R <400> 142 ctccacccac cacaaacact 20 <210> 143 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hRAC1 F <400> 143 catcacctat ccgcagggtc 20 <210> 144 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hRAC1 R <400> 144 tcggatcgct tcgtcaaaca 20 <210> 145 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hRHOA F <400> 145 ggtgatggag cctgtggaaa 20 <210> 146 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hRHOA R <400> 146 tgtgtcccac aaagccaact 20 <210> 147 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSERPINB2 F <400> 147 gctggcacag gaggtgttat 20 <210> 148 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSERPINB2 R <400> 148 agggtgagga aaatctgccg 20 <210> 149 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSERPINE 1 F <400> 149 gggccatgga acaaggatga 20 <210> 150 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSERPINE 1 R <400> 150 ccggaacagc ctgaagaagt 20 <210> 151 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSERPINE2 F <400> 151 aagaaacgca ctttcgtggc 20 <210> 152 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSERPINE2 R <400> 152 ccgtggtagg gcagttcaat 20 <210> 153 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSLC20A1 F <400> 153 gcaactcgtg gcttcgtttt 20 <210> 154 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSLC20A1 R <400> 154 gaccacttga caccctcctg 20 <210> 155 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSLIT2 F <400> 155 aagcttcaga ccatcgccaa 20 <210> 156 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSLIT2 R <400> 156 agccacttga gatggcagtc 20 <210> 157 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSMURF2 F <400> 157 agatcctcgg ctgtctgcta 20 <210> 158 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSMURF2 R <400> 158 ctgaaccagg tctcgcttgt 20 <210> 159 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSTAT3 F <400> 159 ctgtgggaag aatcacgcct 20 <210> 160 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSTAT3 R <400> 160 acatcctgaa ggtgctgctc 20 <210> 161 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSTC1 F <400> 161 ttgctgaggt gcaggaagag 20 <210> 162 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSTC1 R <400> 162 caggcttcgg acaagtctgt 20 <210> 163 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSDC4 F <400> 163 ccctccactt ggaaggacac 20 <210> 164 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSDC4 R <400> 164 caggactaca gcctctccct 20 <210> 165 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTAGLN F <400> 165 aggtctggct gaagaatggc 20 <210> 166 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTAGLN R <400> 166 cacctgctcc atctgcttga 20 <210> 167 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTFPI2 F <400> 167 ctgtctcctg cccctagact 20 <210> 168 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTFPI2 R <400> 168 aaattgttgg cgttgccctc 20 <210> 169 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTGFB1 F <400> 169 tggtggaaac ccacaacgaa 20 <210> 170 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTGFB1 R <400> 170 gagcaacacg ggttcaggta 20 <210> 171 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTGFBR3 F <400> 171 cctcagtcca catccaccac 20 <210> 172 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTGFBR3 R <400> 172 ccacagaacc ctcagacacc 20 <210> 173 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTIMP1 F <400> 173 ggggcttcac caagacctac 20 <210> 174 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTIMP1 R <400> 174 ggaagccctt ttcagagcct 20 <210> 175 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTMEM158 F <400> 175 ctgctgccta gacttcagcc 20 <210> 176 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTMEM158 R <400> 176 ctccacacca cgatgaccag 20 <210> 177 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTNFAIP6 F <400> 177 agcacggtct ggcaaataca 20 <210> 178 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTNFAIP6 R <400> 178 atccatccag cagcacagac 20 <210> 179 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hVEGFA F <400> 179 cttgccttgc tgctctacct 20 <210> 180 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hVEGFA R <400> 180 gcagtagctg cgctgataga 20 <210> 181 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hWNT5A F <400> 181 cgcgaagaca ggcatcaaag 20 <210> 182 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hWNT5A R <400> 182 atctgcatca ccctgccaaa 20 <210> 183 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hGAPDH F <400> 183 tcctgcacca ccaactgttt 20 <210> 184 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hGAPDH R <400> 184 gtccactgtc ttctgggtgg 20 <210> 185 <211> 1805 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1805) <223> mRNA ACTA2 <400> 185 gcaggctctc tccccgcccc cgcggggcgg cgcgcactca cccacccgcg ccggagcgga 60 cctttggctt ggcttgtcag ggcttgtcca ggagttccgc tcctctctcc aaccggggtc 120 cccctccagc gaccctaaag cttcccagac ttccgcttca attcctgtcc gcaccccacg 180 cccacctcaa cgtggagcgc agtggtctcc gaggagcgcc ggagctgccc cgcctgccca 240 gcggggtcag cacttcgcat caaggcccaa gaaaagcaag tcctccagcg ttctgagcac 300 ccgggcctga gggaaggtcc taacagcccc cgggagccag tctccaacgc ctcccgcagc 360 agcccgccgc tcccaggtgc ccgcgtgcgc cgctgccgcc gcaatcccgc acgcgtcccg 420 cgcccgcccc actttgccta tccccgggac taagacggga atcctgtgaa gcagctccag 480 ctatgtgtga agaagaggac agcactgcct tggtgtgtga caatggctct gggctctgta 540 aggccggctt tgctggggac gatgctccca gggctgtttt cccatccatt gtgggacgtc 600 ccagacatca gggggtgatg gtgggaatgg gacaaaaaga cagctacgtg ggtgacgaag 660 cacagagcaa aagaggaatc ctgaccctga agtacccgat agaacatggc atcatcacca 720 actgggacga catggaaaag atctggcacc actctttcta caatgagctt cgtgttgccc 780 ctgaagagca tcccaccctg ctcacggagg cacccctgaa ccccaaggcc aaccgggaga 840 aaatgactca aattatgttt gagactttca atgtcccagc catgtatgtg gctatccagg 900 cggtgctgtc tctctatgcc tctggacgca caactggcat cgtgctggac tctggagatg 960 gtgtcaccca caatgtcccc atctatgagg gctatgcctt gccccatgcc atcatgcgtc 1020 tggatctggc tggccgagat ctcactgact acctcatgaa gatcctgact gagcgtggct 1080 attccttcgt tactactgct gagcgtgaga ttgtccggga catcaaggag aaactgtgtt 1140 atgtagctct ggactttgaa aatgagatgg ccactgccgc atcctcatcc tcccttgaga 1200 agagttacga gttgcctgat gggcaagtga tcaccatcgg aaatgaacgt ttccgctgcc 1260 cagagaccct gttccagcca tccttcatcg ggatggagtc tgctggcatc catgaaacca 1320 cctacaacag catcatgaag tgtgatattg acatcaggaa ggacctctat gctaacaatg 1380 tcctatcagg gggcaccact atgtaccctg gcattgccga ccgaatgcag aaggagatca 1440 cggccctagc acccagcacc atgaagatca agatcattgc ccctccggag cgcaaatact 1500 ctgtctggat cggtggctcc atcctggcct ctctgtccac cttccagcag atgtggatca 1560 gcaaacagga atacgatgaa gccgggcctt ccattgtcca ccgcaaatgc ttctaaaaca 1620 ctttcctgct cctctctgtc tctagcacac aactgtgaat gtcctgtgga attatgcctt 1680 cagttctttt ccaaatcatt cctagccaaa gctctgactc gttacctatg tgttttttaa 1740 taaatctgaa ataggctact ggtaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1800 aaaaa 1805 <210> 186 <211> 5582 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(5582) <223> BAPER mRNA <400> 186 agtggagacg cgccttctcg gctctggtcc gcgccctggg gccctggcct ccctggaggg 60 gctggggaac tggaagctgg gccgagagag ttcccgctgc agctatcgcg cagtccctcc 120 tgcgcccggg cgcccccagc gggttccggg aggcgcccgg tgagcccacg tctgttgcgg 180 cggagcgagc gcgctccggg agggccgaga gccggcgggg ctggcaggag ctctcgggcg 240 cccgcctccc tccttcgcgg acggtctccc gacacgccgg ctgagagccc ttttcgactg 300 tgagctgcgg cagctgagca gaggcggcgg cgcgggacct gcagtcgcca gggattccct 360 ccaggtgacg atgctctggt tctccggcgt cggggctctg gctgagcgtt actgccgccg 420 ctcgcctggg attacgtgct gcgtcttgct gctactcaat tgctcggggg tccccatgtc 480 tctggcttcc tccttcttga caggttctgt tgcaaaatgt gaaaatgaag gtgaagtcct 540 ccagattcca tttatcacag acaacccttg cataatgtgt gtctgcttga acaaggaagt 600 gacatgtaag agagagaagt gccccgtgct gtcccgagac tgtgccctgg ccatcaagca 660 gaggggagcc tgttgtgaac agtgcaaagg ttgcacctat gaaggaaata cctataacag 720 ctccttcaaa tggcagagcc cggctgagcc ttgtgttcta cgccagtgcc aggagggcgt 780 tgtcacagag tctggggtgc gctgtgttgt tcattgtaaa aaccctttgg agcatctggg 840 aatgtgctgc cccacatgtc caggctgtgt gtttgagggt gtgcagtatc aagaagggga 900 ggaatttcag ccagaaggaa gcaaatgtac caagtgttcc tgcactggag gcaggacaca 960 atgtgtgaga gaagtctgtc ccattctctc ctgtccccag caccttagtc acataccccc 1020 aggacagtgc tgccccaaat gtttgggtca gaggaaagtg tttgacctcc cttttgggag 1080 ctgcctcttt cgaagtgatg tttatgacaa tggatcctca tttctgtacg ataactgcac 1140 agcttgtacc tgcagggact ctactgtggt ttgcaagagg aagtgctccc accctggtgg 1200 ctgtgaccaa ggccaggagg gctgttgtga agagtgcctc ctacgagtgc ccccagaaga 1260 catcaaagta tgcaaatttg gcaacaagat tttccaggat ggagagatgt ggtcctctat 1320 caattgtacc atctgtgctt gtgtgaaagg caggacggag tgtcgcaata agcagtgcat 1380 tcccatcagt agctgcccac agggcaaaat tctcaacaga aaaggatgct gtcctatttg 1440 cactgaaaag cccggcgttt gcacggtgtt tggagatccc cactacaaca cttttgacgg 1500 tcggacattt aactttcagg ggacgtgtca gtacgttttg acaaaagact gctcctcccc 1560 tgcctcgccc ttccaggtgc tggtgaagaa cgacgcccgc cggacacgct ccttctcgtg 1620 gaccaagtcg gtggagctgg tgctgggcga gagcagggtc agcctgcagc agcacctcac 1680 cgtgcgctgg aacggctcgc gcatcgcgct cccctgccgc gcgccacact tccacatcga 1740 cctggatggc tacctcttga aagtgaccac caaagcaggt ttggaaatat cttgggatgg 1800 agacagtttt gtagaagtca tggctgcgcc gcatctcaag ggcaagctct gtggtctttg 1860 tggcaactac aatggacata aacgtgatga cttaattggt ggagatggaa acttcaagtt 1920 tgatgtggat gactttgctg aatcttggag ggtggagtcc aatgagttct gcaacagacc 1980 tcagagaaag ccagtgcctg aactgtgtca agggacagtc aaggtaaagc tccgggccca 2040 tcgagaatgc caaaagctca aatcctggga gtttcagacc tgccactcga ctgtggacta 2100 cgccactttc taccggtcct gtgtgacaga catgtgtgaa tgtccagtcc ataaaaactg 2160 ttattgcgag tcatttttgg catatacccg ggcctgccag agagagggca tcaaagtcca 2220 ctgggagcct cagcagaatt gtgcagccac ccagtgtaag catggtgctg tgtacgatac 2280 ctgtggtccg ggatgtatca agacgtgtga caactggaat gaaattggtc catgcaacaa 2340 gccgtgcgtt gctgggtgcc actgtccagc aaacttggtc cttcacaagg gaaggtgcat 2400 caagccagtc ctttgtcccc agcggtgacc tttgtttcga tccttaagac tctgaaatct 2460 ggtgactttg acactgaagc ggaagagcca atgaaggact gcagtatttg tgtgcccgat 2520 tctgtaaaca cacacacaca gagtatatat gtgtatatat atatagatat attcaaaaac 2580 attgcatcat ttatatgaac tataggggga ttattatatg tatatttttt gctataagac 2640 atgtattgtt tctaggatcc taacctgtaa gccattgaac atgttgtata aatacaccag 2700 gtgtttttaa tttaataagg tggcatgcag atacattgga tagtgttaac atcacataca 2760 tttgtcattt ttaaggaagt tttctaagag ccctcaattg cctgcctgta ttaattttag 2820 ttttgagtca ggatttgtaa tggagtggga aatgtgtttc tctggagaag ggcacattta 2880 tctaggggca tttcaggttt ccaaagaaag gaatgtatgc ctgggaaaga cagcaggaga 2940 ttggtgaccg gccctaatgg tgcatgaaaa gcgagtgata ggctgttaga atgtattagg 3000 tcatgggcta acattatttc caaaattgat tggctggttg ccaagaaata tatatttgtc 3060 actagggcat aaccgaagaa tcaagtgatt tcttgccatc cttgcgtagt cctcaagtct 3120 tctaatcatc tatgtgtgta tgatggatgt gaccatttat atgtcatgtg ttgaaattaa 3180 agggtgtctg gatgccatgt taattttatt gagcatgaga aagtatttga agaaactgtt 3240 gcacaacata tgatgaaatt ttgatttctc tgaatctcag agtaatttaa gatgggcaaa 3300 tccaatgagt tgatgtaacc catctacatt ttgtggctat ttcatgtata aaatgaaagg 3360 ctttagttat ttctagagga gtcccatcca acactatttg gcgactgtta atatgttata 3420 attattagac agtggaaaag cctttattga ctaattgatt taacctcagt ccaaagaaca 3480 gtctctatac ttgccctcat ttactgatag gctgctacta gttaccattt gattgtcttg 3540 actttcgtct tcagttgaat tggtgaaaac atcaacaaaa acaaaaccca ctgtgtctta 3600 aaataaaatg ttctgcattg tagtcaataa agggcttaag atgtaaaaca atgcattttc 3660 tctctcaaga tgtcctgtgt tatactttac aattagttgt atcaacttca gattcattaa 3720 attttaacag ctgtatttag ttataatttt tgtatcttac aacagtatat ataaagacta 3780 ttattaatag acaaaagcaa acccacgttt ttgacaagcc agcatattgc caatgctcgt 3840 caaagacatt tatgtttctt ttacattcat gacagctaaa gtattaactt ggaatttttt 3900 tttttttttt tgactggaaa atccctagtt gtttgaatta actgaataaa gtgcagggcg 3960 taatagtgac tggctggggg cactgggcct ttgtgttttt tttcattcct gtgtttggat 4020 actaatcacc ctcgtatctg cagcctgagg tagtcaggtc attgtttcaa tgctgccctt 4080 ggaaagaaga ctttgactta ggtgctttgg gatctaagtg tggtttgtga ctatccccat 4140 tatttaagca tttgggggtc tcacttttgc ttatctgtaa cacaaagagg ccatgtagta 4200 tagtgagcag ggttgagaat cgggaaaact agacccctgc cactaacagg ctaggagact 4260 ttgggcagta atgggaggca ctgagggttt gcaaatactt tcctacttgt aatctcattg 4320 attccctgct ctgccctgac aggaggggta gggaaaatca gttgacgttg cctggtggtt 4380 cctaccttct gtaaaacgaa cagattcctt aagattagct ttaaatccct tttcagttca 4440 ctgttggttc tcatctttga aagagggcag cataagggaa atgatggaga agggagaatt 4500 gtggatggtt atttatagct catgattcat ccaaggactg agttattctc cccatgaggc 4560 taaccggcct ctttcccaac acttaatcat ggcagccagg atgggtgaat gatgaaagct 4620 cttctgcatg agccggtttc atcatcttgg gtgggttgat tacaagtttg tgtggcattc 4680 ctttagctgg ggattagctt aatctctgta catttttctc atttctaatt gaagaagaaa 4740 gggagggcag agaggacaga aaattacttg ggtttactaa ttcaaagagc catctctgat 4800 gggagagggt gaggaaatca gctgaatggt tggcctgcat attctttttt aggccacagg 4860 ctacagctga gcaatggctt agtctaatga ttgggcacaa tgaggattta ccaagtgctt 4920 caatgagagc agtcctgttt cattcacatg ggatgttttc aattggttct tcaactaagc 4980 tcttgcagag tgagatgact tgaaataaaa atgttctatg aatattgaat ttgatgagaa 5040 acaagcaccc tcaatgaaga acaagcataa ttatgattct aattgcccat tgttggtact 5100 cagtaaaact aagttctttc ttctctccct ctgtaaatag gaatatttga gggtcctgac 5160 ctaaaatttt ttagctggga agaaaagata tctctttggc atcgacaaga gcaatttttg 5220 ttaaaactgt ggtacactaa gaatcactaa ctcttcaggt tgaaggcctc actcatctta 5280 actcgttgac tgcttcctga ccatcagacc gtcctgtaag agggcatctt tcaataagaa 5340 cgagaaagac ccaggaggtt gactagcttc tcccagcttt cactgaaaca cggataaacc 5400 atttcaactg gaaaactctt cctttttatg agatatttca gacacacaaa aaggcataga 5460 gaaaaatgtt gcaaacatcc atgactacat taccctaatt aagaaacata acctggtaag 5520 tagtcaataa atttttcttg aatcaataaa taaaacctaa taaatgctgt ctcatggttg 5580 ca 5582 <210> 187 <211> 741 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(741) <223> CCL2 mRNA <400> 187 gagaggctga gactaaccca gaaacatcca attctcaaac tgaagctcgc actctcgcct 60 ccagcatgaa agtctctgcc gcccttctgt gcctgctgct catagcagcc accttcattc 120 cccaagggct cgctcagcca gatgcaatca atgccccagt cacctgctgt tataacttca 180 ccaataggaa gatctcagtg cagaggctcg cgagctatag aagaatcacc agcagcaagt 240 gtcccaaaga agctgtgatc ttcaagacca ttgtggccaa ggagatctgt gctgacccca 300 agcagaagtg ggttcaggat tccatggacc acctggacaa gcaaacccaa actccgaaga 360 cttgaacact cactccacaa cccaagaatc tgcagctaac ttattttccc ctagctttcc 420 ccagacaccc tgttttattt tattataatg aattttgttt gttgatgtga aacattatgc 480 cttaagtaat gttaattctt atttaagtta ttgatgtttt aagtttatct ttcatggtac 540 tagtgttttt tagatacaga gacttgggga aattgctttt cctcttgaac cacagttcta 600 cccctgggat gttttgaggg tctttgcaag aatcattaat acaaagaatt ttttttaaca 660 ttccaatgca ttgctaaaat attattgtgg aaatgaatat tttgtaacta ttacaccaaa 720 taaatatatt tttgtacaaa a 741 <210> 188 <211> 1378 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1378) <223> CH25H mRNA <400> 188 agctgccttg cacagcctcg caatgagctg ccacaactgc tccgaccccc aggtcctttg 60 cagctccggg cagctgttcc tgcagcccct ctgggaccac ctgaggagct gggaggccct 120 cctacagtcg cccttcttcc cggtcatctt ctccatcacc acatacgtgg gcttttgcct 180 gcccttcgtg gtcctggata tcctgtgctc ctgggtgccc gccctgcggc gctacaagat 240 ccaccctgac ttctcgccat ccgcgcagca gctgctacct tgcctggggc agaccctcta 300 ccagcatgtg atgtttgtgt tccccgtgac gctgctgcat tgggcccgca gcccggccct 360 cctgccccac gaagctcccg agctgctcct gctgctgcac cacatcctgt tctgcctgct 420 actcttcgac atggagttct tcgtgtggca cctgctgcac cacaaggtgc cctggctgta 480 ccgcaccttc cacaaggtgc accaccagaa ctcgtcctcg ttcgcgctgg caacgcagta 540 tatgagcgtc tgggaactgt tttctttggg cttcttcgac atgatgaacg tcacactgct 600 cgggtgccac ccgctcacca ccctgacctt ccacgtggtc aacatctggc tttccgtgga 660 ggaccactcc ggctacaact tcccttggtc cactcacaga ctggtgccct tcgggtggta 720 cgggggtgtg gtgcaccacg acctgcatca ctctcacttt aactgcaact tcgctccgta 780 ctttacacac tgggacaaaa tactgggaac gctgcggact gcatctgtcc cagcgcggtg 840 atgtggctgc ggtgggtgcc cctaagactc gggactgctg tgcctttcac acttgaatga 900 agagaaacac ctgagctata tattttttta aagcaactaa cttattgctt tatgtttatc 960 tatgaaaacc atagataaaa tctgatgcat ttttgtaatc tgacaaagta atttacatac 1020 tgtttgtgta tcaatacaat tttgtgttct tggtattctt agtctagctc acctcaatag 1080 ccttgaatcc tgcatatgaa ttagacattc atcactggca tatttagaat atctctaaaa 1140 ggacttgttt gtagaataag gaattttcta tgtttcaaag tgttctaaaa cctggctaaa 1200 agaatgtatt tttgtggatg gtgttgactt ctgactctaa aagcaatcaa acatgtttct 1260 gctggacagt gaccaagaat tatagtacct tcttatattt ttttatagaa ctgtatattt 1320 attttgaaag aaatgttatt cgtgctttaa aaaggaaaaa aaaccatgaa tcaaataa 1378 <210> 189 <211> 5927 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(5927) <223> COL1A1 mRNA <400> 189 tcgtcggagc agacgggagt ttctcctcgg ggtcggagca ggaggcacgc ggagtgtgag 60 gccacgcatg agcggacgct aaccccctcc ccagccacaa agagtctaca tgtctagggt 120 ctagacatgt tcagctttgt ggacctccgg ctcctgctcc tcttagcggc caccgccctc 180 ctgacgcacg gccaagagga aggccaagtc gagggccaag acgaagacat cccaccaatc 240 acctgcgtac agaacggcct caggtaccat gaccgagacg tgtggaaacc cgagccctgc 300 cggatctgcg tctgcgacaa cggcaaggtg ttgtgcgatg acgtgatctg tgacgagacc 360 aagaactgcc ccggcgccga agtccccgag ggcgagtgct gtcccgtctg ccccgacggc 420 tcagagtcac ccaccgacca agaaaccacc ggcgtcgagg gacccaaggg agacactggc 480 ccccgaggcc caaggggacc cgcaggcccc cctggccgag atggcatccc tggacagcct 540 ggacttcccg gaccccccgg accccccgga cctcccggac cccctggcct cggaggaaac 600 tttgctcccc agctgtctta tggctatgat gagaaatcaa ccggaggaat ttccgtgcct 660 ggccccatgg gtccctctgg tcctcgtggt ctccctggcc cccctggtgc acctggtccc 720 caaggcttcc aaggtccccc tggtgagcct ggcgagcctg gagcttcagg tcccatgggt 780 ccccgaggtc ccccaggtcc ccctggaaag aatggagatg atggggaagc tggaaaacct 840 ggtcgtcctg gtgagcgtgg gcctcctggg cctcagggtg ctcgaggatt gcccggaaca 900 gctggcctcc ctggaatgaa gggacacaga ggtttcagtg gtttggatgg tgccaaggga 960 gatgctggtc ctgctggtcc taagggtgag cctggcagcc ctggtgaaaa tggagctcct 1020 ggtcagatgg gcccccgtgg cctgcctggt gagagaggtc gccctggagc ccctggccct 1080 gctggtgctc gtggaaatga tggtgctact ggtgctgccg ggccccctgg tcccaccggc 1140 cccgctggtc ctcctggctt ccctggtgct gttggtgcta agggtgaagc tggtccccaa 1200 gggccccgag gctctgaagg tccccagggt gtgcgtggtg agcctggccc ccctggccct 1260 gctggtgctg ctggccctgc tggaaaccct ggtgctgatg gacagcctgg tgctaaaggt 1320 gccaatggtg ctcctggtat tgctggtgct cctggcttcc ctggtgcccg aggcccctct 1380 ggaccccagg gccccggcgg ccctcctggt cccaagggta acagcggtga acctggtgct 1440 cctggcagca aaggagacac tggtgctaag ggagagcctg gccctgttgg tgttcaagga 1500 ccccctggcc ctgctggaga ggaaggaaag cgaggagctc gaggtgaacc cggacccact 1560 ggcctgcccg gaccccctgg cgagcgtggt ggacctggta gccgtggttt ccctggcgca 1620 gatggtgttg ctggtcccaa gggtcccgct ggtgaacgtg gttctcctgg ccctgctggc 1680 cccaaaggat ctcctggtga agctggtcgt cccggtgaag ctggtctgcc tggtgccaag 1740 ggtctgactg gaagccctgg cagccctggt cctgatggca aaactggccc ccctggtccc 1800 gccggtcaag atggtcgccc cggaccccca ggcccacctg gtgcccgtgg tcaggctggt 1860 gtgatgggat tccctggacc taaaggtgct gctggagagc ccggcaaggc tggagagcga 1920 ggtgttcccg gaccccctgg cgctgtcggt cctgctggca aagatggaga ggctggagct 1980 cagggacccc ctggccctgc tggtcccgct ggcgagagag gtgaacaagg ccctgctggc 2040 tcccccggat tccagggtct ccctggtcct gctggtcctc caggtgaagc aggcaaacct 2100 ggtgaacagg gtgttcctgg agaccttggc gcccctggcc cctctggagc aagaggcgag 2160 agaggtttcc ctggcgagcg tggtgtgcaa ggtccccctg gtcctgctgg tccccgaggg 2220 gccaacggtg ctcccggcaa cgatggtgct aagggtgatg ctggtgcccc tggagctccc 2280 ggtagccagg gcgcccctgg ccttcaggga atgcctggtg aacgtggtgc agctggtctt 2340 ccagggccta agggtgacag aggtgatgct ggtcccaaag gtgctgatgg ctctcctggc 2400 aaagatggcg tccgtggtct gactggcccc attggtcctc ctggccctgc tggtgcccct 2460 ggtgacaagg gtgaaagtgg tcccagcggc cctgctggtc ccactggagc tcgtggtgcc 2520 cccggagacc gtggtgagcc tggtcccccc ggccctgctg gctttgctgg cccccctggt 2580 gctgacggcc aacctggtgc taaaggcgaa cctggtgatg ctggtgctaa aggcgatgct 2640 ggtccccctg gccctgccgg acccgctgga ccccctggcc ccattggtaa tgttggtgct 2700 cctggagcca aaggtgctcg cggcagcgct ggtccccctg gtgctactgg tttccctggt 2760 gctgctggcc gagtcggtcc tcctggcccc tctggaaatg ctggaccccc tggccctcct 2820 ggtcctgctg gcaaagaagg cggcaaaggt ccccgtggtg agactggccc tgctggacgt 2880 cctggtgaag ttggtccccc tggtccccct ggccctgctg gcgagaaagg atcccctggt 2940 gctgatggtc ctgctggtgc tcctggtact cccgggcctc aaggtattgc tggacagcgt 3000 ggtgtggtcg gcctgcctgg tcagagagga gagagaggct tccctggtct tcctggcccc 3060 tctggtgaac ctggcaaaca aggtccctct ggagcaagtg gtgaacgtgg tccccctggt 3120 cccatgggcc cccctggatt ggctggaccc cctggtgaat ctggacgtga gggggctcct 3180 ggtgccgaag gttcccctgg acgagacggt tctcctggcg ccaagggtga ccgtggtgag 3240 accggccccg ctggaccccc tggtgctcct ggtgctcctg gtgcccctgg ccccgttggc 3300 cctgctggca agagtggtga tcgtggtgag actggtcctg ctggtcccgc cggtcctgtc 3360 ggccctgttg gcgcccgtgg ccccgccgga ccccaaggcc cccgtggtga caagggtgag 3420 acaggcgaac agggcgacag aggcataaag ggtcaccgtg gcttctctgg cctccagggt 3480 ccccctggcc ctcctggctc tcctggtgaa caaggtccct ctggagcctc tggtcctgct 3540 ggtccccgag gtccccctgg ctctgctggt gctcctggca aagatggact caacggtctc 3600 cctggcccca ttgggccccc tggtcctcgc ggtcgcactg gtgatgctgg tcctgttggt 3660 ccccccggcc ctcctggacc tcctggtccc cctggtcctc ccagcgctgg tttcgacttc 3720 agcttcctgc cccagccacc tcaagagaag gctcacgatg gtggccgcta ctaccgggct 3780 gatgatgcca atgtggttcg tgaccgtgac ctcgaggtgg acaccaccct caagagcctg 3840 agccagcaga tcgagaacat ccggagccca gagggcagcc gcaagaaccc cgcccgcacc 3900 tgccgtgacc tcaagatgtg ccactctgac tggaagagtg gagagtactg gattgacccc 3960 aaccaaggct gcaacctgga tgccatcaaa gtcttctgca acatggagac tggtgagacc 4020 tgcgtgtacc ccactcagcc cagtgtggcc cagaagaact ggtacatcag caagaacccc 4080 aaggacaaga ggcatgtctg gttcggcgag agcatgaccg atggattcca gttcgagtat 4140 ggcggccagg gctccgaccc tgccgatgtg gccatccagc tgaccttcct gcgcctgatg 4200 tccaccgagg cctcccagaa catcacctac cactgcaaga acagcgtggc ctacatggac 4260 cagcagactg gcaacctcaa gaaggccctg ctcctccagg gctccaacga gatcgagatc 4320 cgcgccgagg gcaacagccg cttcacctac agcgtcactg tcgatggctg cacgagtcac 4380 accggagcct ggggcaagac agtgattgaa tacaaaacca ccaagacctc ccgcctgccc 4440 atcatcgatg tggccccctt ggacgttggt gccccagacc aggaattcgg cttcgacgtt 4500 ggccctgtct gcttcctgta aactccctcc atcccaacct ggctccctcc cacccaacca 4560 actttccccc caacccggaa acagacaagc aacccaaact gaaccccctc aaaagccaaa 4620 aaatgggaga caatttcaca tggactttgg aaaatatttt tttcctttgc attcatctct 4680 caaacttagt ttttatcttt gaccaaccga acatgaccaa aaaccaaaag tgcattcaac 4740 cttaccaaaa aaaaaaaaaa aaaaagaata aataaataac tttttaaaaa aggaagcttg 4800 gtccacttgc ttgaagaccc atgcgggggt aagtcccttt ctgcccgttg ggcttatgaa 4860 accccaatgc tgccctttct gctcctttct ccacaccccc cttggggcct cccctccact 4920 ccttcccaaa tctgtctccc cagaagacac aggaaacaat gtattgtctg cccagcaatc 4980 aaaggcaatg ctcaaacacc caagtggccc ccaccctcag cccgctcctg cccgcccagc 5040 acccccaggc cctgggggac ctggggttct cagactgcca aagaagcctt gccatctggc 5100 gctcccatgg ctcttgcaac atctcccctt cgtttttgag ggggtcatgc cgggggagcc 5160 accagcccct cactgggttc ggaggagagt caggaagggc cacgacaaag cagaaacatc 5220 ggatttgggg aacgcgtgtc aatcccttgt gccgcagggc tgggcgggag agactgttct 5280 gttccttgtg taactgtgtt gctgaaagac tacctcgttc ttgtcttgat gtgtcaccgg 5340 ggcaactgcc tgggggcggg gatgggggca gggtggaagc ggctccccat tttataccaa 5400 aggtgctaca tctatgtgat gggtggggtg gggagggaat cactggtgct atagaaattg 5460 agatgccccc ccaggccagc aaatgttcct ttttgttcaa agtctatttt tattccttga 5520 tatttttctt tttttttttt tttttttgtg gatggggact tgtgaatttt tctaaaggtg 5580 ctatttaaca tgggaggaga gcgtgtgcgg ctccagccca gcccgctgct cactttccac 5640 cctctctcca cctgcctctg gcttctcagg cctctgctct ccgacctctc tcctctgaaa 5700 ccctcctcca cagctgcagc ccatcctccc ggctccctcc tagtctgtcc tgcgtcctct 5760 gtccccgggt ttcagagaca acttcccaaa gcacaaagca gtttttcccc ctaggggtgg 5820 gaggaagcaa aagactctgt acctattttg tatgtgtata ataatttgag atgtttttaa 5880 ttattttgat tgctggaata aagcatgtgg aaatgaccca aacataa 5927 <210> 190 <211> 5411 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(5411) <223> COL1A2 mRNA <400> 190 gtgtcccata gtgtttccaa acttggaaag ggcgggggag ggcgggagga tgcggagggc 60 ggaggtatgc agacaacgag tcagagtttc cccttgaaag cctcaaaagt gtccacgtcc 120 tcaaaaagaa tggaaccaat ttaagaagcc agccccgtgg ccacgtccct tcccccattc 180 gctccctcct ctgcgccccc gcaggctcct cccagctgtg gctgcccggg cccccagccc 240 cagccctccc attggtggag gcccttttgg aggcacccta gggccaggga aacttttgcc 300 gtataaatag ggcagatccg ggctttatta ttttagcacc acggcagcag gaggtttcgg 360 ctaagttgga ggtactggcc acgactgcat gcccgcgccc gccaggtgat acctccgccg 420 gtgacccagg ggctctgcga cacaaggagt ctgcatgtct aagtgctaga catgctcagc 480 tttgtggata cgcggacttt gttgctgctt gcagtaacct tatgcctagc aacatgccaa 540 tctttacaag aggaaactgt aagaaagggc ccagccggag atagaggacc acgtggagaa 600 aggggtccac caggcccccc aggcagagat ggtgaagatg gtcccacagg ccctcctggt 660 ccacctggtc ctcctggccc ccctggtctc ggtgggaact ttgctgctca gtatgatgga 720 aaaggagttg gacttggccc tggaccaatg ggcttaatgg gacctagagg cccacctggt 780 gcagctggag ccccaggccc tcaaggtttc caaggacctg ctggtgagcc tggtgaacct 840 ggtcaaactg gtcctgcagg tgctcgtggt ccagctggcc ctcctggcaa ggctggtgaa 900 gatggtcacc ctggaaaacc cggacgacct ggtgagagag gagttgttgg accacagggt 960 gctcgtggtt tccctggaac tcctggactt cctggcttca aaggcattag gggacacaat 1020 ggtctggatg gattgaaggg acagcccggt gctcctggtg tgaagggtga acctggtgcc 1080 cctggtgaaa atggaactcc aggtcaaaca ggagcccgtg ggcttcctgg tgagagagga 1140 cgtgttggtg cccctggccc agctggtgcc cgtggcagtg atggaagtgt gggtcccgtg 1200 ggtcctgctg gtcccattgg gtctgctggc cctccaggct tcccaggtgc ccctggcccc 1260 aagggtgaaa ttggagctgt tggtaacgct ggtcctgctg gtcccgccgg tccccgtggt 1320 gaagtgggtc ttccaggcct ctccggcccc gttggacctc ctggtaatcc tggagcaaac 1380 ggccttactg gtgccaaggg tgctgctggc cttcccggcg ttgctggggc tcccggcctc 1440 cctggacccc gcggtattcc tggccctgtt ggtgctgccg gtgctactgg tgccagagga 1500 cttgttggtg agcctggtcc agctggctcc aaaggagaga gcggtaacaa gggtgagccc 1560 ggctctgctg ggccccaagg tcctcctggt cccagtggtg aagaaggaaa gagaggccct 1620 aatggggaag ctggatctgc cggccctcca ggacctcctg ggctgagagg tagtcctggt 1680 tctcgtggtc ttcctggagc tgatggcaga gctggcgtca tgggccctcc tggtagtcgt 1740 ggtgcaagtg gccctgctgg agtccgagga cctaatggag atgctggtcg ccctggggag 1800 cctggtctca tgggacccag aggtcttcct ggttcccctg gaaatatcgg ccccgctgga 1860 aaagaaggtc ctgtcggcct ccctggcatc gacggcaggc ctggcccaat tggcccagct 1920 ggagcaagag gagagcctgg caacattgga ttccctggac ccaaaggccc cactggtgat 1980 cctggcaaaa acggtgataa aggtcatgct ggtcttgctg gtgctcgggg tgctccaggt 2040 cctgatggaa acaatggtgc tcagggacct cctggaccac agggtgttca aggtggaaaa 2100 ggtgaacagg gtccccctgg tcctccaggc ttccagggtc tgcctggccc ctcaggtccc 2160 gctggtgaag ttggcaaacc aggagaaagg ggtctccatg gtgagtttgg tctccctggt 2220 cctgctggtc caagagggga acgcggtccc ccaggtgaga gtggtgctgc cggtcctact 2280 ggtcctattg gaagccgagg tccttctgga cccccagggc ctgatggaaa caagggtgaa 2340 cctggtgtgg ttggtgctgt gggcactgct ggtccatctg gtcctagtgg actcccagga 2400 gagaggggtg ctgctggcat acctggaggc aagggagaaa agggtgaacc tggtctcaga 2460 ggtgaaattg gtaaccctgg cagagatggt gctcgtggtg ctcctggtgc tgtaggtgcc 2520 cctggtcctg ctggagccac aggtgaccgg ggcgaagctg gggctgctgg tcctgctggt 2580 cctgctggtc ctcggggaag ccctggtgaa cgtggtgagg tcggtcctgc tggccccaat 2640 ggatttgctg gtcctgctgg tgctgctggt caacctggtg ctaaaggaga aagaggagcc 2700 aaagggccta agggtgaaaa cggtgttgtt ggtcccacag gccccgttgg agctgctggc 2760 ccagctggtc caaatggtcc ccccggtcct gctggaagtc gtggtgatgg aggcccccct 2820 ggtatgactg gtttccctgg tgctgctgga cggactggtc ccccaggacc ctctggtatt 2880 tctggccctc ctggtccccc tggtcctgct gggaaagaag ggcttcgtgg tcctcgtggt 2940 gaccaaggtc cagttggccg aactggagaa gtaggtgcag ttggtccccc tggcttcgct 3000 ggtgagaagg gtccctctgg agaggctggt actgctggac ctcctggcac tccaggtcct 3060 cagggtcttc ttggtgctcc tggtattctg ggtctccctg gctcgagagg tgaacgtggt 3120 ctaccaggtg ttgctggtgc tgtgggtgaa cctggtcctc ttggcattgc cggccctcct 3180 ggggcccgtg gtcctcctgg tgctgtgggt agtcctggag tcaacggtgc tcctggtgaa 3240 gctggtcgtg atggcaaccc tgggaacgat ggtcccccag gtcgcgatgg tcaacccgga 3300 cacaagggag agcgcggtta ccctggcaat attggtcccg ttggtgctgc aggtgcacct 3360 ggtcctcatg gccccgtggg tcctgctggc aaacatggaa accgtggtga aactggtcct 3420 tctggtcctg ttggtcctgc tggtgctgtt ggcccaagag gtcctagtgg cccacaaggc 3480 attcgtggcg ataagggaga gcccggtgaa aaggggccca gaggtcttcc tggcttaaag 3540 ggacacaatg gattgcaagg tctgcctggt atcgctggtc accatggtga tcaaggtgct 3600 cctggctccg tgggtcctgc tggtcctagg ggccctgctg gtccttctgg ccctgctgga 3660 aaagatggtc gcactggaca tcctggtaca gttggacctg ctggcattcg aggccctcag 3720 ggtcaccaag gccctgctgg cccccctggt ccccctggcc ctcctggacc tccaggtgta 3780 agcggtggtg gttatgactt tggttacgat ggagacttct acagggctga ccagcctcgc 3840 tcagcacctt ctctcagacc caaggactat gaagttgatg ctactctgaa gtctctcaac 3900 aaccagattg agacccttct tactcctgaa ggctctagaa agaacccagc tcgcacatgc 3960 cgtgacttga gactcagcca cccagagtgg agcagtggtt actactggat tgaccctaac 4020 caaggatgca ctatggatgc tatcaaagta tactgtgatt tctctactgg cgaaacctgt 4080 atccgggccc aacctgaaaa catcccagcc aagaactggt ataggagctc caaggacaag 4140 aaacacgtct ggctaggaga aactatcaat gctggcagcc agtttgaata taatgtagaa 4200 ggagtgactt ccaaggaaat ggctacccaa cttgccttca tgcgcctgct ggccaactat 4260 gcctctcaga acatcaccta ccactgcaag aacagcattg catacatgga tgaggagact 4320 ggcaacctga aaaaggctgt cattctacag ggctctaatg atgttgaact tgttgctgag 4380 ggcaacagca ggttcactta cactgttctt gtagatggct gctctaaaaa gacaaatgaa 4440 tggggaaaga caatcattga atacaaaaca aataagccat cacgcctgcc cttccttgat 4500 attgcacctt tggacatcgg tggtgctgac caggaattct ttgtggacat tggcccagtc 4560 tgtttcaaat aaatgaactc aatctaaatt aaaaaagaaa gaaatttgaa aaaactttct 4620 ctttgccatt tcttcttctt cttttttaac tgaaagctga atccttccat ttcttctgca 4680 catctacttg cttaaattgt gggcaaaaga gaaaaagaag gattgatcag agcattgtgc 4740 aatacagttt cattaactcc ttcccccgct cccccaaaaa tttgaatttt tttttcaaca 4800 ctcttacacc tgttatggaa aatgtcaacc tttgtaagaa aaccaaaata aaaattgaaa 4860 aataaaaacc ataaacattt gcaccacttg tggcttttga atatcttcca cagagggaag 4920 tttaaaaccc aaacttccaa aggtttaaac tacctcaaaa cactttccca tgagtgtgat 4980 ccacattgtt aggtgctgac ctagacagag atgaactgag gtccttgttt tgttttgttc 5040 ataatacaaa ggtgctaatt aatagtattt cagatacttg aagaatgttg atggtgctag 5100 aagaatttga gaagaaatac tcctgtattg agttgtatcg tgtggtgtat tttttaaaaa 5160 atttgattta gcattcatat tttccatctt attcccaatt aaaagtatgc agattatttg 5220 cccaaatctt cttcagattc agcatttgtt ctttgccagt ctcattttca tcttcttcca 5280 tggttccaca gaagctttgt ttcttgggca agcagaaaaa ttaaattgta cctattttgt 5340 atatgtgaga tgtttaaata aattgtgaaa aaaatgaaat aaagcatgtt tggttttcca 5400 aaagaacata t 5411 <210> 191 <211> 5490 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(5490) <223> COL3A1 mRNA <400> 191 ggctgagttt tatgacgggc ccggtgctga agggcaggga acaacttgat ggtgctactt 60 tgaactgctt ttcttttctc ctttttgcac aaagagtctc atgtctgata tttagacatg 120 atgagctttg tgcaaaaggg gagctggcta cttctcgctc tgcttcatcc cactattatt 180 ttggcacaac aggaagctgt tgaaggagga tgttcccatc ttggtcagtc ctatgcggat 240 agagatgtct ggaagccaga accatgccaa atatgtgtct gtgactcagg atccgttctc 300 tgcgatgaca taatatgtga cgatcaagaa ttagactgcc ccaacccaga aattccattt 360 ggagaatgtt gtgcagtttg cccacagcct ccaactgctc ctactcgccc tcctaatggt 420 caaggacctc aaggccccaa gggagatcca ggccctcctg gtattcctgg gagaaatggt 480 gaccctggta ttccaggaca accagggtcc cctggttctc ctggcccccc tggaatctgt 540 gaatcatgcc ctactggtcc tcagaactat tctccccagt atgattcata tgatgtcaag 600 tctggagtag cagtaggagg actcgcaggc tatcctggac cagctggccc cccaggccct 660 cccggtcccc ctggtacatc tggtcatcct ggttcccctg gatctccagg ataccaagga 720 ccccctggtg aacctgggca agctggtcct tcaggccctc caggacctcc tggtgctata 780 ggtccatctg gtcctgctgg aaaagatgga gaatcaggta gacccggacg acctggagag 840 cgaggattgc ctggacctcc aggtatcaaa ggtccagctg ggatacctgg attccctggt 900 atgaaaggac acagaggctt cgatggacga aatggagaaa agggtgaaac aggtgctcct 960 ggattaaagg gtgaaaatgg tcttccaggc gaaaatggag ctcctggacc catgggtcca 1020 agaggggctc ctggtgagcg aggacggcca ggacttcctg gggctgcagg tgctcggggt 1080 aatgacggtg ctcgaggcag tgatggtcaa ccaggccctc ctggtcctcc tggaactgcc 1140 ggattccctg gatcccctgg tgctaagggt gaagttggac ctgcagggtc tcctggttca 1200 aatggtgccc ctggacaaag aggagaacct ggacctcagg gacacgctgg tgctcaaggt 1260 cctcctggcc ctcctgggat taatggtagt cctggtggta aaggcgaaat gggtcccgct 1320 ggcattcctg gagctcctgg actgatggga gcccggggtc ctccaggacc agccggtgct 1380 aatggtgctc ctggactgcg aggtggtgca ggtgagcctg gtaagaatgg tgccaaagga 1440 gagcccggac cacgtggtga acgcggtgag gctggtattc caggtgttcc aggagctaaa 1500 ggcgaagatg gcaaggatgg atcacctgga gaacctggtg caaatgggct tccaggagct 1560 gcaggagaaa ggggtgcccc tgggttccga ggacctgctg gaccaaatgg catcccagga 1620 gaaaagggtc ctgctggaga gcgtggtgct ccaggccctg cagggcccag aggagctgct 1680 ggagaacctg gcagagatgg cgtccctgga ggtccaggaa tgaggggcat gcccggaagt 1740 ccaggaggac caggaagtga tgggaaacca gggcctcccg gaagtcaagg agaaagtggt 1800 cgaccaggtc ctcctgggcc atctggtccc cgaggtcagc ctggtgtcat gggcttcccc 1860 ggtcctaaag gaaatgatgg tgctcctggt aagaatggag aacgaggtgg ccctggagga 1920 cctggccctc agggtcctcc tggaaagaat ggtgaaactg gacctcaggg acccccaggg 1980 cctactgggc ctggtggtga caaaggagac acaggacccc ctggtccaca aggattacaa 2040 ggcttgcctg gtacaggtgg tcctccagga gaaaatggaa aacctgggga accaggtcca 2100 aagggtgatg ccggtgcacc tggagctcca ggaggcaagg gtgatgctgg tgcccctggt 2160 gaacgtggac ctcctggatt ggcaggggcc ccaggactta gaggtggagc tggtccccct 2220 ggtcccgaag gaggaaaggg tgctgctggt cctcctgggc cacctggtgc tgctggtact 2280 cctggtctgc aaggaatgcc tggagaaaga ggaggtcttg gaagtcctgg tccaaagggt 2340 gacaagggtg aaccaggcgg tccaggtgct gatggtgtcc cagggaaaga tggcccaagg 2400 ggtcctactg gtcctattgg tcctcctggc ccagctggcc agcctggaga taagggtgaa 2460 ggtggtgccc ccggacttcc aggtatagct ggacctcgtg gtagccctgg tgagagaggt 2520 gaaactggcc ctccaggacc tgctggtttc cctggtgctc ctggacagaa tggtgaacct 2580 ggtggtaaag gagaaagagg ggctccgggt gagaaaggtg aaggaggccc tcctggagtt 2640 gcaggacccc ctggaggttc tggacctgct ggtcctcctg gtccccaagg tgtcaaaggt 2700 gaacgtggca gtcctggtgg acctggtgct gctggcttcc ctggtgctcg tggtcttcct 2760 ggtcctcctg gtagtaatgg taacccagga cccccaggtc ccagcggttc tccaggcaag 2820 gatgggcccc caggtcctgc gggtaacact ggtgctcctg gcagccctgg agtgtctgga 2880 ccaaaaggtg atgctggcca accaggagag aagggatcgc ctggtgccca gggcccacca 2940 ggagctccag gcccacttgg gattgctggg atcactggag cacggggtct tgcaggacca 3000 ccaggcatgc caggtcctag gggaagccct ggccctcagg gtgtcaaggg tgaaagtggg 3060 aaaccaggag ctaacggtct cagtggagaa cgtggtcccc ctggacccca gggtcttcct 3120 ggtctggctg gtacagctgg tgaacctgga agagatggaa accctggatc agatggtctt 3180 ccaggccgag atggatctcc tggtggcaag ggtgatcgtg gtgaaaatgg ctctcctggt 3240 gcccctggcg ctcctggtca tccaggccca cctggtcctg tcggtccagc tggaaagagt 3300 ggtgacagag gagaaagtgg ccctgctggc cctgctggtg ctcccggtcc tgctggttcc 3360 cgaggtgctc ctggtcctca aggcccacgt ggtgacaaag gtgaaacagg tgaacgtgga 3420 gctgctggca tcaaaggaca tcgaggattc cctggtaatc caggtgcccc aggttctcca 3480 ggccctgctg gtcagcaggg tgcaatcggc agtccaggac ctgcaggccc cagaggacct 3540 gttggaccca gtggacctcc tggcaaagat ggaaccagtg gacatccagg tcccattgga 3600 ccaccagggc ctcgaggtaa cagaggtgaa agaggatctg agggctcccc aggccaccca 3660 gggcaaccag gccctcctgg acctcctggt gcccctggtc cttgctgtgg tggtgttgga 3720 gccgctgcca ttgctgggat tggaggtgaa aaagctggcg gttttgcccc gtattatgga 3780 gatgaaccaa tggatttcaa aatcaacacc gatgagatta tgacttcact caagtctgtt 3840 aatggacaaa tagaaagcct cattagtcct gatggttctc gtaaaaaccc cgctagaaac 3900 tgcagagacc tgaaattctg ccatcctgaa ctcaagagtg gagaatactg ggttgaccct 3960 aaccaaggat gcaaattgga tgctatcaag gtattctgta atatggaaac tggggaaaca 4020 tgcataagtg ccaatccttt gaatgttcca cggaaacact ggtggacaga ttctagtgct 4080 gagaagaaac acgtttggtt tggagagtcc atggatggtg gttttcagtt tagctacggc 4140 aatcctgaac ttcctgaaga tgtccttgat gtgcagctgg cattccttcg acttctctcc 4200 agccgagctt cccagaacat cacatatcac tgcaaaaata gcattgcata catggatcag 4260 gccagtggaa atgtaaagaa ggccctgaag ctgatggggt caaatgaagg tgaattcaag 4320 gctgaaggaa atagcaaatt cacctacaca gttctggagg atggttgcac gaaacacact 4380 ggggaatgga gcaaaacagt ctttgaatat cgaacacgca aggctgtgag actacctatt 4440 gtagatattg caccctatga cattggtggt cctgatcaag aatttggtgt ggacgttggc 4500 cctgtttgct ttttataaac caaactctat ctgaaatccc aacaaaaaaa atttaactcc 4560 atatgtgttc ctcttgttct aatcttgtca accagtgcaa gtgaccgaca aaattccagt 4620 tatttatttc caaaatgttt ggaaacagta taatttgaca aagaaaaatg atacttctct 4680 ttttttgctg ttccaccaaa tacaattcaa atgctttttg ttttattttt ttaccaattc 4740 caatttcaaa atgtctcaat ggtgctataa taaataaact tcaacactct ttatgataac 4800 aacactgtgt tatattcttt gaatcctagc ccatctgcag agcaatgact gtgctcacca 4860 gtaaaagata acctttcttt ctgaaatagt caaatacgaa attagaaaag ccctccctat 4920 tttaactacc tcaactggtc agaaacacag attgtattct atgagtccca gaagatgaaa 4980 aaaattttat acgttgataa aacttataaa tttcattgat taatctcctg gaagattggt 5040 ttaaaaagaa aagtgtaatg caagaattta aagaaatatt tttaaagcca caattatttt 5100 aatattggat atcaactgct tgtaaaggtg ctcctctttt ttcttgtcat tgctggtcaa 5160 gattactaat atttgggaag gctttaaaga cgcatgttat ggtgctaatg tactttcact 5220 tttaaactct agatcagaat tgttgacttg cattcagaac ataaatgcac aaaatctgta 5280 catgtctccc atcagaaaga ttcattggca tgccacaggg gattctcctc cttcatcctg 5340 taaaggtcaa caataaaaac caaattatgg ggctgctttt gtcacactag catagagaat 5400 gtgttgaaat ttaactttgt aagcttgtat gtggttgttg atcttttttt tccttacaga 5460 cacccataat aaaatatcat attaaaattc 5490 <210> 192 <211> 6540 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6540) <223> COL4A1 mRNA <400> 192 aggtctccgc ttggagccgc cgcacccggg acggtgcgta gcgctggaag tccggccttc 60 cgagagctag ctgtccgccg cggcccccgc acgccgggca gccgtccctc gccgcctcgg 120 gcgcgccacc atggggcccc ggctcagcgt ctggctgctg ctgctgcccg ccgcccttct 180 gctccacgag gagcacagcc gggccgctgc gaagggtggc tgtgctggct ctggctgtgg 240 caaatgtgac tgccatggag tgaagggaca aaagggtgaa agaggcctcc cggggttaca 300 aggtgtcatt gggtttcctg gaatgcaagg acctgagggg ccacagggac caccaggaca 360 aaagggtgat actggagaac caggactacc tggaacaaaa gggacaagag gacctccggg 420 agcatctggc taccctggaa acccaggact tcccggaatt cctggccaag acggcccgcc 480 aggcccccca ggtattccag gatgcaatgg cacaaagggg gagagagggc cgctcgggcc 540 tcctggcttg cctggtttcg ctggaaatcc cggaccacca ggcttaccag ggatgaaggg 600 tgatccaggt gagatacttg gccatgtgcc cgggatgctg ttgaaaggtg aaagaggatt 660 tcccggaatc ccagggactc caggcccacc aggactgcca gggcttcaag gtcctgttgg 720 gcctccagga tttaccggac caccaggtcc cccaggccct cccggccctc caggtgaaaa 780 gggacaaatg ggcttaagtt ttcaaggacc aaaaggtgac aagggtgacc aaggggtcag 840 tgggcctcca ggagtaccag gacaagctca agttcaagaa aaaggagact tcgccaccaa 900 gggagaaaag ggccaaaaag gtgaacctgg atttcagggg atgccagggg tcggagagaa 960 aggtgaaccc ggaaaaccag gacccagagg caaacccgga aaagatggtg acaaagggga 1020 aaaagggagt cccggttttc ctggtgaacc cgggtaccca ggactcatag gccgccaggg 1080 cccgcaggga gaaaagggtg aagcaggtcc tcctggccca cctggaattg ttataggcac 1140 aggacctttg ggagaaaaag gagagagggg ctaccctgga actccggggc caagaggaga 1200 gccaggccca aaaggtttcc caggactacc aggccaaccc ggacctccag gcctccctgt 1260 acctgggcag gctggtgccc ctggcttccc tggtgaaaga ggagaaaaag gtgaccgagg 1320 atttcctggt acatctctgc caggaccaag tggaagagat gggctcccgg gtcctcctgg 1380 ttcccctggg ccccctgggc agcctggcta cacaaatgga attgtggaat gtcagcccgg 1440 acctccaggt gaccagggtc ctcctggaat tccagggcag ccaggattta taggcgaaat 1500 tggagagaaa ggtcaaaaag gagagagttg cctcatctgt gatatagacg gatatcgggg 1560 gcctcccggg ccacagggac ccccgggaga aataggtttc ccagggcagc caggggccaa 1620 gggcgacaga ggtttgcctg gcagagatgg tgttgcagga gtgccaggcc ctcaaggtac 1680 accagggctg ataggccagc caggagccaa gggggagcct ggtgagtttt atttcgactt 1740 gcggctcaaa ggtgacaaag gagacccagg ctttccagga cagcccggca tgccagggag 1800 agcgggttct cctggaagag atggccatcc gggtcttcct ggccccaagg gctcgccggg 1860 ttctgtagga ttgaaaggag agcgtggccc ccctggagga gttggattcc caggcagtcg 1920 tggtgacacc ggcccccctg ggcctccagg atatggtcct gctggtccca ttggtgacaa 1980 aggacaagca ggctttcctg gaggccctgg atccccaggc ctgccaggtc caaagggtga 2040 accaggaaaa attgttcctt taccaggccc ccctggagca gaaggactgc cggggtcccc 2100 aggcttccca ggtccccaag gagaccgagg ctttcccgga accccaggaa ggccaggcct 2160 gccaggagag aagggcgctg tgggccagcc aggcattgga tttccagggc cccccggccc 2220 caaaggtgtt gacggcttac ctggagacat ggggccaccg gggactccag gtcgcccggg 2280 atttaatggc ttacctggga acccaggtgt gcagggccag aagggagagc ctggagttgg 2340 tctaccggga ctcaaaggtt tgccaggtct tcccggcatt cctggcacac ccggggagaa 2400 ggggagcatt ggggtaccag gcgttcctgg agaacatgga gcgatcggac cccctgggct 2460 tcaggggatc agaggtgaac cgggacctcc tggattgcca ggctccgtgg ggtctccagg 2520 agttccagga ataggccccc ctggagctag gggtccccct ggaggacagg gaccaccggg 2580 gttgtcaggc cctcctggaa taaaaggaga gaagggtttc cccggattcc ctggactgga 2640 catgccgggc cctaaaggag ataaaggggc tcaaggactc cctggcataa cgggacagtc 2700 ggggctccct ggccttcctg gacagcaggg ggctcctggg attcctgggt ttccaggttc 2760 caagggagaa atgggcgtca tggggacccc cgggcagccg ggctcaccag gaccagtggg 2820 tgctcctgga ttaccgggtg aaaaagggga ccatggcttt ccgggctcct caggacccag 2880 gggagaccct ggcttgaaag gtgataaggg ggatgtcggt ctccctggca agcctggctc 2940 catggataag gtggacatgg gcagcatgaa gggccagaaa ggagaccaag gagagaaagg 3000 acaaattgga ccaattggtg agaagggatc ccgaggagac cctgggaccc caggagtgcc 3060 tggaaaggac gggcaggcag gacagcctgg gcagccagga cctaaaggtg atccaggtat 3120 aagtggaacc ccaggtgctc caggacttcc gggaccaaaa ggatctgttg gtggaatggg 3180 cttgccagga acacctggag agaaaggtgt gcctggcatc cctggcccac aaggttcacc 3240 tggcttacct ggagacaaag gtgcaaaagg agagaaaggg caggcaggcc cacctggcat 3300 aggcatccca gggctgcgag gtgaaaaggg agatcaaggg atagcgggtt tcccaggaag 3360 ccctggagag aagggagaaa aaggaagcat tgggatccca ggaatgccag ggtccccagg 3420 ccttaaaggg tctcccggga gtgttggcta tccaggaagt cctgggctac ctggagaaaa 3480 aggtgacaaa ggcctcccag gattggatgg catccctggt gtcaaaggag aagcaggtct 3540 tcctgggact cctggcccca caggcccagc tggccagaaa ggggagccag gcagtgatgg 3600 aatcccgggg tcagcaggag agaagggtga accaggtcta ccaggaagag gattcccagg 3660 gtttccaggg gccaaaggag acaaaggttc aaagggtgag gtgggtttcc caggattagc 3720 cgggagccca ggaattcctg gatccaaagg agagcaagga ttcatgggtc ctccggggcc 3780 ccagggacag ccggggttac cgggatcccc aggccatgcc acggaggggc ccaaaggaga 3840 ccgcggacct cagggccagc ctggcctgcc aggacttccg ggacccatgg ggcctccagg 3900 gcttcctggg attgatggag ttaaaggtga caaaggaaat ccaggctggc caggagcacc 3960 cggtgtccca gggcccaagg gagaccctgg attccagggc atgcctggta ttggtggctc 4020 tccaggaatc acaggctcta agggtgatat ggggcctcca ggagttccag gatttcaagg 4080 tccaaaaggt cttcctggcc tccagggaat taaaggtgat caaggcgatc aaggcgtccc 4140 gggagctaaa ggtctcccgg gtcctcctgg ccccccaggt ccttacgaca tcatcaaagg 4200 ggagcccggg ctccctggtc ctgagggccc cccagggctg aaagggcttc agggactgcc 4260 aggcccgaaa ggccagcaag gtgttacagg attggtgggt atacctggac ctccaggtat 4320 tcctgggttt gacggtgccc ctggccagaa aggagagatg ggacctgccg ggcctactgg 4380 tccaagagga tttccaggtc caccaggccc cgatgggttg ccaggatcca tggggccccc 4440 aggcacccca tctgttgatc acggcttcct tgtgaccagg catagtcaaa caatagatga 4500 cccacagtgt ccttctggga ccaaaattct ttaccacggg tactctttgc tctacgtgca 4560 aggcaatgaa cgggcccatg gccaggactt gggcacggcc ggcagctgcc tgcgcaagtt 4620 cagcacaatg cccttcctgt tctgcaatat taacaacgtg tgcaactttg catcacgaaa 4680 tgactactcg tactggctgt ccacccctga gcccatgccc atgtcaatgg cacccatcac 4740 gggggaaaac ataagaccat ttattagtag gtgtgctgtg tgtgaggcgc ctgccatggt 4800 gatggccgtg cacagccaga ccattcagat cccaccgtgc cccagcgggt ggtcctcgct 4860 gtggatcggc tactcttttg tgatgcacac cagcgctggt gcagaaggct ctggccaagc 4920 cctggcgtcc cccggctcct gcctggagga gtttagaagt gcgccattca tcgagtgtca 4980 cggccgtggg acctgcaatt actacgcaaa cgcttacagc ttttggctcg ccaccataga 5040 gaggagcgag atgttcaaga agcctacgcc gtccaccttg aaggcagggg agctgcgcac 5100 gcacgtcagc cgctgccaag tctgtatgag aagaacataa tgaagcctga ctcagctaat 5160 gtcacaacat ggtgctactt cttcttcttt ttgttaacag caacgaaccc tagaaatata 5220 tcctgtgtac ctcactgtcc aatatgaaaa ccgtaaagtg ccttatagga atttgcgtaa 5280 ctaacacacc ctgcttcatt gacctctact tgctgaagga gaaaaagaca gcgataagct 5340 ttcaatagtg gcataccaaa tggcactttt gatgaaataa aatatcaata ttttctgcaa 5400 tccaatgcac tgatgtgtga agtgagaact ccatcagaaa accaaagggt gctaggaggt 5460 gtgggtgcct tccatactgt ttgcccattt tcattcttgt attataatta attttctacc 5520 cccagagata aatgtttgtt tatatcactg tctagctgtt tcaaaattta ggtcccttgg 5580 tctgtacaaa taatagcaat gtaaaaatgg ttttttgaac ctccaaatgg aattacagac 5640 tcagtagcca tatcttccaa ccccccagta taaatttctg tctttctgct atgtgtggta 5700 ctttgcagct gcttttgcag aaatcacaat tttcctgtgg aataaagatg gtccaaaaat 5760 agtcaaaaat taaatatata tatatattag taatttatat agatgtcagc aattaggcag 5820 atcaaggttt agtttaactt ccactgttaa aataaagctt acatagtttt cttcctttga 5880 aagactgtgc tgtcctttaa cataggtttt taaagactag gatattgaat gtgaaacatc 5940 cgttttcatt gttcacttct aaaccaaaaa ttatgtgttg ccaaaaccaa acccaggttc 6000 atgaatatgg tgtctattat agtgaaacat gtactttgag cttattgttt ttattctgta 6060 ttaaatattt tcagggtttt aaacactaat cacaaactga atgacttgac ttcaaaagca 6120 acaaccttaa aggccgtcat ttcattagta ttcctcattc tgcatcctgg cttgaaaaac 6180 agctctgttg aatcacagta tcagtatttt cacacgtaag cacattcggg ccatttccgt 6240 ggtttctcat gagctgtgtt cacagacctc agcagggcat cgcatggacc gcaggagggc 6300 agattcggac cactaggcct gaaatgacat ttcactaaaa gtctccaaaa catttctaag 6360 actactaagg ccttttatgt aatttcttta aatgtgtatt tcttaagaat tcaaatttgt 6420 aataaaacta tttgtataaa aattaagctt ttattaattt gttgctagta ttgccacaga 6480 cgcattaaaa gaaacttact gcacaagctg ctaataaatt tgtaagcttt gcatacctta 6540 6540 <210> 193 <211> 8455 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(8455) <223> COL5A1 mRNA <400> 193 ccgcactctc cgtccccgcg gctggcgcag gacctcactc gagcggagcg cccacgggga 60 gcgggtcgcg gggcggcggc ggcgaggagg aggcgagaag gagttggagg aggaggagga 120 ggaggcgagg gcgagctagc ccagcggggt cccggccgcc ccgcgggcca aagtcgagcc 180 ctcccgcccg tgggcgagcg cgccagccgc cccttccaga acagccgccg ccacaaagaa 240 gaacgggggg tgccgaggtc cccatgacct cctaaagtgg tgcggtccct gctgagtgcg 300 ctgcccgggc cgtgacccgc gcccctgtgc gtccccgcgc gcctccgagc gcccctgtgc 360 gccccggccc gcgccccgcc ggcatggacg tccatacccg ctggaaagcg cgcagcgcgc 420 tccgcccggg cgccccgctg ctgcccccgc tgctgctgct gctgctgtgg gcgccgcctc 480 cgagccgcgc agctcagcca gcagatctcc tgaaggttct agattttcac aacttgcctg 540 atggaataac aaagacaaca ggcttttgcg ccacgcggcg atcttccaaa ggcccggatg 600 tcgcttacag agtcaccaaa gacgcgcagc tcagcgcacc caccaagcag ctgtaccctg 660 cgtctgcatt tcccgaggac ttctccatcc taacaactgt gaaagccaag aaaggcagcc 720 aggccttcct ggtctccatc tacaacgagc agggtatcca gcagattggg ctggagctgg 780 gccgctctcc cgtcttcctc tacgaggacc acacggggaa gcctggcccg gaagactacc 840 ccctcttccg gggcatcaac ctgtcagatg gcaagtggca cagaattgct ctcagcgtcc 900 acaagaaaaa tgtcaccttg atcctcgact gtaaaaagaa gaccaccaaa ttcctcgacc 960 gcagcgacca ccccatgatc gacatcaatg gcatcatcgt gtttggcacc cggatcctgg 1020 atgaggaggt gtttgagggt gacatccagc agctgctctt tgtctcggac caccgggcag 1080 cttatgatta ctgtgagcac tacagccctg actgtgacac cgcagtacct gacaccccac 1140 agtcgcagga ccccaatcca gatgaatatt acacggaagg agacggcgag ggtgagacct 1200 attactacga atacccctac tacgaagacc ccgaagacct agggaaggag cccaccccca 1260 gcaagaagcc cgtggaagct gccaaagaaa ccacagaggt ccccgaggag ctgaccccga 1320 cccccacgga agctgctccc atgcctgaaa ccagtgaagg ggctgggaag gaagaggacg 1380 tcggcatcgg ggactatgac tacgtgccca gtgaggacta ctacacgccc tcaccgtatg 1440 atgacctcac ctatggcgag ggggaggaga accccgacca gcccacagac ccaggcgctg 1500 gggccgaaat tcccaccagc accgccgaca cctccaactc ctccaatcca gctccgcctc 1560 caggggaagg tgcggatgac ttggaggggg agttcactga ggaaacgatc cggaaccttg 1620 acgagaacta ctacgacccc tactacgacc ccaccagctc cccgtcggag atcgggccgg 1680 gaatgccggc gaaccaggat accatctatg aagggattgg aggacctcgg ggcgagaaag 1740 gccaaaaggg agaaccagcg attatcgagc cgggcatgct catcgagggc ccgcctggcc 1800 cagaaggccc cgcgggtctt cccggacctc caggaaccat gggtcccact ggccaagtcg 1860 gggaccctgg agaaaggggc ccccctggac gcccaggcct tcctggggcc gatggcctgc 1920 ccggtcctcc aggaaccatg ctcatgctgc ccttccggtt tggaggtggc ggcgatgcgg 1980 gctccaaagg ccccatggtc tcagcccagg agtcccaggc gcaagccatt ctccagcagg 2040 ccaggttggc actgagggga ccagctggcc cgatgggtct cacagggaga cctggccctg 2100 tgggtccccc tgggagcgga ggtttgaagg gcgagccggg agacgtgggg cctcagggtc 2160 ctcgaggtgt gcaaggcccg cctggtccgg ccgggaagcc cggaagacgg ggtcgggctg 2220 ggagtgatgg agccagagga atgcctggac aaactggccc caagggtgac cggggtttcg 2280 acggcctggc tgggttgcca ggcgagaagg gccacagggg tgaccctggt ccttccggcc 2340 caccaggacc tccgggagac gatggagaaa ggggtgacga cggagaagtt gggcccaggg 2400 ggctgcctgg ggagcccggg ccacgtggtc tgcttgggcc gaaggggccc ccaggtcctc 2460 ccggacctcc cggtgtcacg ggtatggacg gccagccggg gccaaaagga aatgtgggtc 2520 cccagggaga gcctggcccc ccaggacagc agggtaatcc aggcgcccag ggtcttccag 2580 gcccccaggg tgcaattggt cctccaggag aaaagggtcc cttggggaaa ccaggccttc 2640 caggaatgcc cggtgctgac ggacccccgg gacaccctgg caaagaaggc cctccaggag 2700 agaaaggagg tcagggtcca cctggccccc agggtccgat tggctaccca ggtcctcgag 2760 gagtcaaggg ggccgatggc atccgtggtc tgaagggcac aaagggcgag aagggtgaag 2820 acggctttcc tgggtttaaa ggagacatgg gcatcaaggg tgatcggggg gagatcggcc 2880 cacccggtcc caggggagaa gatggccctg aaggcccaaa gggtcgcgga ggtcccaatg 2940 gtgaccccgg tcctctggga ccccctgggg agaagggaaa actcggagtc ccagggttac 3000 cagggtatcc aggaagacaa ggaccaaagg gctctattgg attccctgga tttcctggcg 3060 ccaatggaga gaagggcggc agggggaccc ctggaaagcc aggaccgcgg gggcagcgag 3120 gcccaacggg tccgaggggt gaaagaggcc cccggggcat cactgggaag cctggcccca 3180 agggcaactc cggaggtgac ggcccagctg gccctcctgg tgaacgggga cccaatggac 3240 cccaaggacc cacaggattt cctggaccaa agggcccccc tggccctcca ggcaaggatg 3300 gactcccagg acaccctgga cagagaggcg agactggttt ccaaggcaag accggccctc 3360 caggcccccc cggcgtggtc ggccctcagg gtcccacggg agaaacgggc ccaatgggtg 3420 agcgtggcca ccctgggccc cctggacccc ccggtgaaca ggggcttccg ggccttgctg 3480 gaaaagaagg gacgaagggt gacccaggcc ctgcaggcct ccctgggaaa gatggccctc 3540 caggattacg tggtttccct ggggaccgag ggcttcctgg tccagtggga gctcttggac 3600 tgaaaggcaa tgaagggccc cctggcccac caggccctgc gggatctcca ggggagagag 3660 gtccagctgg agccgctggg cccatcggaa ttccagggag acctgggccc cagggacccc 3720 cagggccggc aggagagaaa ggggctcctg gcgagaaagg cccacaaggc ccagctggcc 3780 gagacggtct ccaggggcct gtggggctcc cgggtccagc tggccctgtg ggtccccctg 3840 gagaagacgg agataaggga gagatcgggg agccggggca gaaaggaagc aagggggaca 3900 aaggagaaca gggtcctcct gggcctacag gtcctcaagg ccccatcgga cagccaggcc 3960 cctctggagc tgacggcgag ccggggcctc ggggccagca gggccttttc gggcagaaag 4020 gtgatgaagg tcccagaggc tttcctggac cccctgggcc agtggggctg cagggtttgc 4080 caggacctcc aggcgagaag ggtgagacag gagacgtggg ccagatgggc cccccgggtc 4140 cccctggccc ccgaggaccc tccggagctc caggtgctga tggcccacaa ggtcccccag 4200 gtggaatagg aaaccctggt gcagtgggag agaagggcga gcctggcgaa gcaggtgagc 4260 ctggccttcc gggagaaggc ggccccccgg gacccaaagg agaaagggga gagaagggcg 4320 agtcaggccc ttcaggtgct gccggacccc ctggacccaa aggccctccc ggagatgatg 4380 gtcccaaagg cagccctggc ccagtgggtt ttcctggaga tcctggcccc cccggagagc 4440 ctggccccgc gggtcaagat ggtccccctg gtgacaaagg agatgatggt gaacccgggc 4500 agacgggatc ccccggccct actggtgaac caggtccatc ggggcctcca ggaaaaaggg 4560 gtcccccagg ccccgcaggc cccgaaggca gacagggaga gaaaggggcc aagggagaag 4620 ccggcttgga aggccctcct gggaagactg gccccatcgg cccccagggg gcccctggga 4680 agcccggacc ggatggcctt cgagggatcc ctggccctgt gggagaacaa ggtctcccag 4740 gatccccagg cccggacggt ccccccggcc ccatgggtcc cccaggactt cccggcctca 4800 aaggagattc tggtcccaaa ggtgaaaagg gtcatccagg cctgatcggg ctcatcggtc 4860 ctccgggtga acagggtgag aagggcgacc gtggtctccc tggcccccag ggctcctccg 4920 gtcctaaggg agaacagggt atcactggtc cttctggccc gattgggcct cctgggcccc 4980 ctggcctgcc gggtccgcct ggtccaaaag gtgctaaggg ctcctcgggt ccaactggcc 5040 cgaagggtga ggcaggccac ccaggacccc caggcccccc gggccccccg ggagaggtca 5100 tccagcccct gccaatccag gcatccagga cgcggcggaa catcgacgcc agccagctgc 5160 tggacgacgg gaatggcgag aactacgtgg actacgcgga cggcatggaa gagatcttcg 5220 gctctctcaa ctctctgaag ctggagattg agcagatgaa acggcccctg ggcacgcagc 5280 agaaccccgc ccgcacctgc aaggacctgc agctctgcca ccccgacttc ccagatggtg 5340 aatactgggt cgatcctaac caaggatgct ccagggattc cttcaaggtt tactgcaact 5400 tcacagccgg ggggtcgaca tgcgtcttcc ctgacaagaa gtccgaaggg gccagaatca 5460 cttcttggcc caaagaaaac ccgggctcct ggttcagtga attcaagcgt gggaaactgc 5520 tctcctatgt ggacgccgag ggcaaccctg tgggtgtggt acagatgacc ttcctgcggc 5580 tgctgagcgc ctctgcccac cagaacgtca cctaccactg ctaccagtca gtggcctggc 5640 aggacgcagc cacgggcagc tacgacaagg ccctccgctt cctgggctcc aacgacgagg 5700 agatgtccta tgacaacaac ccctacatcc gcgccctggt ggacggctgt gctaccaaga 5760 aaggctacca gaagacggtt ctggagatcg acacccccaa agtggagcag gtgcccatcg 5820 tggacatcat gttcaatgac ttcggtgaag cgtcacagaa atttggattt gaagtggggc 5880 cggcttgctt catgggctag gagccgccga gcccgggctc ccgagagcaa cctcgtgacc 5940 tcagcatgcc attcgttcgt gagtgtcccg tgcacgtcct gaccctggac agtgaaggct 6000 tctccctccc ctcccacctg acttcatcta cgcctcggca ccacggggtg tgggacccca 6060 gcccggagag aacagaggga aggagccgcg cccccacctg gagctgaatc acatgaccta 6120 gctgcacccc agcgcctggg cccgccccac gctctgtcca cacccacgcg ccccgggagc 6180 ggggccatgc ctccagcccc ccagctcgcc cgacccatcc tgttcgtgaa taggtctcag 6240 gggttggggg agggactgcc agatttggac actatatttt tttctaaatt caacttgaag 6300 atgtgtattt cccctgacct tcaaaaaatg ttccaaggta agcctcgtaa aggtcatccc 6360 accatcacca aagcctccgt ttttaacaac ctccaacacg atccatttag aggccaaatg 6420 tcattctgca ggtgccttcc cgatggatta aaggtgctta tgtttttgtg agttttaagt 6480 aaatatttgt attgtattgt tataaatgtt aagtgtgcct ggctttcaat catgcacgga 6540 aacccagtct cagtcccacg gacagaatgg gcgaggcatg gattctgggt tgcagtaccg 6600 ttctgattag aaataggaag tctccccacc cccgccctgg ccaagaacgt gcaataaatt 6660 ggaagtttgc cccggggcag caagaattta tgctgccatt gaaaagcagg taccagtgcc 6720 ccttttcaga cagtttttga ttcgctctag actttttttt tttttaatag ggaaaaaatt 6780 tgataatttt cttttttcta catgcactta agactaaaac acaggtttgg attaatttta 6840 tttgcttcct ttttccgctt ttcttcccgc agagcctgat gggagaatgt ccagggcagg 6900 gaaaccacat tttttgtagg tgataactca atgaaaattg gtgcttattt tttacacttc 6960 tctcttgtgg ctctcttgtg gtgctatcta tctgttttaa ggtctccttg aaggcgcact 7020 ggggaccctg gccatgcctc gttctccctg ctttctttat cctgttattg cctccacagt 7080 ctgttgccaa ggactctaag atcaatgcac gtcactttcc tttccactgg gcaggatagc 7140 caagcacact ccctcctgcg ctctcccgcc ccggtgcgtc cactcccgag ggctgttatg 7200 aggactgggt tgtgcctact tgatttgaaa acacacacaa gcaataaaaa gcctcttcct 7260 gcattgtctg tggtgtgacc atagcagatt atatttggtt cctgaatgtt tgtggtgcta 7320 atttctgtgt ttgttccaag ccgttcagtc atgccatgcg ctgcctcggt agatggagta 7380 atgtacaatg aactccatga gtctctccag ggctgcctgc agcacgtctt ttccaagtag 7440 cctatttgga ttcccatctc aaatgtcctg gatgcgagcg tcagcggctc cagagctcgg 7500 ggcgggtgag gtcccctttg gggaaccctt tcctggccat cgaggtcggg gggctgccgt 7560 ctgtgggcag gaggacccga ggggcagcca ggaaaggcga tctcttcact gtgaaaagtt 7620 gcccgggtgc agcgcctttt ccttctacca tgggaaatgc aggctgggcc cttggggtga 7680 gcctgcgggg ctctggtgct gtccccgacc cccaccacca ccagaatgca gttccagctt 7740 aggaagccac aaacaagcca cccaggagga acaaaacacc gccagcgtgg attttccaaa 7800 tttccctgga aagtaagtct cgctcttgcc aaagaaaagt ctggcttgga gagtctctgg 7860 agcccaggat gccagcatgt gccaatgact gtcaccttca tctcttcaaa agaaaagcca 7920 tagccgagga ctgtcccgcg acccccgtgg actgcgtcta ggtcatgtga ttctgttttc 7980 atttctcatc ccatccaatt tgtccttttc tcctgtcatt ttcttcctct gtggtccctt 8040 caaagttgtt ataatttgta ctgaacttca aaatgtgtcc cgttctcccc agaccactct 8100 agccacagta tattgcaata aaattacttc ttatatttgc agaaattctt ttggtgtaat 8160 tttatttttt cctctcaata tatataattg gacaaacgct ggcaaaaaga aaaaaatggt 8220 aagcaaaaaa cccaagataa agtttcgagg acatcaggcc ttttgaaata caatgtcaaa 8280 tgacacattg tacggtttca aaaaatccgc tagacatgtc ataagtttta actgtaatgc 8340 ccaggaaagg atatcttaaa atattctaaa cttgtgtaac aaaggaataa ttaactgtaa 8400 tagtttttca ataaatcgag ttgggtgttt ccaccgtaaa aaaaaaaaaa aaaaa 8455 <210> 194 <211> 6829 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6829) <223> COL5A2 mRNA <400> 194 gcagactgtg ctggagctgg tgctgaaaaa gggggtttgc agaggctgcc ctggggctgg 60 tgctgaaaga agagcccaca gctgacttca tggtgctaca ataacctcag aatctacttt 120 tcactctcag gagaacccac atgtctaata tttagacatg atggcaaact gggcggaagc 180 aagacctctc ctcattctta ttgttttatt agggcaattt gtctcaataa aagcccagga 240 agaagacgag gatgaaggat atggtgaaga aatagcctgc actcagaatg gccagatgta 300 cttaaacagg gacatttgga aacctgcccc ttgtcagatc tgtgtctgtg acaatggagc 360 cattctctgt gacaagatag aatgccagga tgtgctggac tgtgccgacc ctgtaacgcc 420 ccctggggaa tgctgtcctg tctgttcaca aacacctgga ggtggcaata ccaattttgg 480 tagaggaaga aagggacaaa agggagaacc aggattagtg cctgttgtaa caggcatacg 540 tggtcgtcca ggaccggcag gacctccagg atcacaggga ccaagaggag agcgagggcc 600 aaaaggaaga cctggccctc gtggacctca gggaattgat ggagaaccag gtgttcctgg 660 tcaacctggt gctccaggac ctcctggaca tccgtcccac ccaggacccg atggcttgag 720 caggccgttt tcagctcaaa tggctgggtt ggatgaaaaa tctggacttg ggagtcaagt 780 aggactaatg cctggctctg tgggtcctgt tggcccaagg ggaccacagg gtttacaagg 840 acagcaaggt ggtgcaggac ctacaggacc tcctggtgaa cctggtgatc ctggaccaat 900 gggtccgatt ggttcacgtg gaccagaggg ccctcctggt aaacctgggg aagatggtga 960 acctggcaga aatggaaatc ctggtgaagt gggatttgca ggatctccgg gagctcgtgg 1020 atttcctggg gctcctggtc ttccaggtct gaagggtcac cgaggacaca aaggtcttga 1080 aggccctaaa ggtgaagttg gagcacctgg ttccaagggt gaagctggcc ccactggtcc 1140 aatgggtgcc atgggtcctc tgggtccgag gggaatgcca ggagagagag ggagacttgg 1200 gccacagggt gctcctggac aacgaggtgc acatggtatg cctggaaaac ctggaccaat 1260 gggtcctctt gggataccag gctcttctgg ttttccagga aatcctggaa tgaagggaga 1320 agcaggtcct acaggggcgc gaggccctga aggtcctcag gggcagagag gtgaaactgg 1380 gcccccaggt ccagttggct ctccaggtct tcctggtgca ataggaactg atggtactcc 1440 tggtgccaaa ggcccaacgg gctctccagg tacctctggt cctcctggct cagcagggcc 1500 tcctggatct ccaggacctc agggtagcac tggtcctcag ggaattcgag gccaaccggg 1560 tgatccagga gttccaggtt tcaaaggaga agctggccca aaaggggaac cagggccaca 1620 tggtattcag ggtccgatag gcccacccgg tgaagaaggc aaaagaggtc ccagaggtga 1680 cccaggaaca gttggtcctc cagggccagt gggagaaagg ggtgctcctg gcaatcgtgg 1740 ttttccaggc tctgatggtt tacctgggcc aaagggtgct caaggagaac ggggtcctgt 1800 aggttcttca ggacccaaag gaagccaggg ggatccagga cgtccagggg aacctgggct 1860 tccaggtgct cggggtttga caggaaatcc tggtgttcaa ggtcctgaag gaaaacttgg 1920 acctttgggt gcgccagggg aagatggccg tccaggtcct ccaggctcca taggaatcag 1980 agggcagccc gggagcatgg gccttccagg ccccaaaggt agcagtggtg accctgggaa 2040 acctggagaa gcaggaaatg ctggagttcc tgggcagagg ggagctcctg gaaaagatgg 2100 tgaagttggt ccttctggtc ctgtgggccc gccgggtcta gctggtgaaa gaggagaaca 2160 aggacctcca ggccccacag gttttcaggg gcttcctggt cctccagggc ctcctggaga 2220 aggtggaaaa ccaggtgatc aaggtgttcc tggagatccc ggagcagttg gcccgttagg 2280 acctagagga gaacgaggaa atcctgggga aagaggagaa cctgggataa ctggactccc 2340 tggtgagaag ggaatggctg gaggacatgg tcctgatggc ccaaaaggca gtccaggtcc 2400 atctgggacc cctggagata caggcccacc aggtcttcaa ggtatgccgg gagaaagagg 2460 aattgcagga actcctggcc ccaagggtga cagaggtggc ataggagaaa aaggtgctga 2520 aggcacagct ggaaatgatg gtgcaagagg tcttccaggt cctttgggcc ctccaggtcc 2580 ggcaggtcct actggagaaa agggtgaacc tggtcctcga ggtttagttg gccctcctgg 2640 ctcccggggc aatcctggtt ctcgaggtga aaatgggcca actggagctg ttggttttgc 2700 cggaccccag ggtcctgacg gacagcctgg agtaaaaggt gaacctggag agccaggaca 2760 gaagggagat gctggttctc ctggaccaca aggtttagca ggatcccctg gccctcatgg 2820 tcctaatggt gttcctggac taaaaggtgg tcgaggaacc caaggtccgc ctggtgctac 2880 aggatttcct ggttctgcgg gcagagttgg acctccaggc cctgctggag ctccaggacc 2940 tgcgggaccc ctaggggaac ccgggaagga gggacctcca ggtcttcgtg gggaccctgg 3000 ctctcatggg cgtgtgggag atcgaggacc agctggcccc cctggtggcc caggagacaa 3060 aggggaccca ggagaagatg ggcaacctgg tccagatggc ccccctggtc cagctggaac 3120 gaccgggcag agaggaattg ttggcatgcc tgggcaacgt ggagagagag gcatgcccgg 3180 cctaccaggc ccagcgggaa caccaggaaa agtaggacca actggtgcaa caggagataa 3240 aggtccacct ggacctgtgg ggcccccagg ctccaatggt cctgtagggg aacctggacc 3300 agaaggtcca gctggcaatg atggtacccc aggacgggat ggtgctgttg gagaacgtgg 3360 tgatcgtgga gaccctgggc ctgcaggtct gccaggctct cagggtgccc ctggaactcc 3420 tggccctgtg ggtgctccag gagatgcagg acaaagagga gatccgggtt ctcggggtcc 3480 tataggacca cctggtcgag ctgggaaacg tggattacct ggaccccaag gacctcgtgg 3540 tgacaaaggt gatcatggag accgaggtga cagaggtcag aagggccaca gaggctttac 3600 tggtcttcag ggtcttcctg gccctcctgg tccaaatggt gaacaaggaa gtgctggaat 3660 ccctggacca tttggcccaa gaggtcctcc aggcccagtt ggtccttcag gtaaagaagg 3720 aaaccctggg ccacttgggc caattggacc tccaggtgta cgaggcagtg taggagaagc 3780 aggacctgag ggccctcctg gtgagcctgg cccacctggc cctccgggtc cccctggcca 3840 ccttacagct gctcttgggg atatcatggg gcactatgat gaaagcatgc cagatccact 3900 tcctgagttt actgaagatc aggcggctcc tgatgacaaa aacaaaacgg acccaggggt 3960 tcatgctacc ctgaagtcac tcagtagtca gattgaaacc atgcgcagcc ccgatggctc 4020 gaaaaagcac ccagcccgca cgtgtgatga cctaaagctt tgccattccg caaagcagag 4080 tggtgaatac tggattgatc ctaaccaagg atctgttgaa gatgcaatca aagtttactg 4140 caacatggaa acaggagaaa catgtatttc agcaaaccca tccagtgtac cacgtaaaac 4200 ctggtgggcc agtaaatctc ctgacaataa acctgtttgg tatggtcttg atatgaacag 4260 agggtctcag ttcgcttatg gagaccacca atcacctaat acagccatta ctcagatgac 4320 ttttttgcgc cttttatcaa aagaagcctc ccagaacatc acttacatct gtaaaaacag 4380 tgtaggatac atggacgatc aagctaagaa cctcaaaaaa gctgtggttc tcaaaggggc 4440 aaatgactta gatatcaaag cagagggaaa tattagattc cggtatatcg ttcttcaaga 4500 cacttgctct aagcggaatg gaaatgtggg caagactgtc tttgaatata gaacacagaa 4560 tgtggcacgc ttgcccatca tagatcttgc tcctgtggat gttggcggca cagaccagga 4620 attcggcgtt gaaattgggc cagtttgttt tgtgtaaagt aagccaagac acatcgacaa 4680 tgagcaccac catcaatgac caccgccatt cacaagaact ttgactgttt gaagttgatc 4740 ctgagactct tgaagtaatg gctgatcctg catcagcatt gtatatatgg tcttaagtgc 4800 ctggcctcct tatccttcag aatatttatt ttacttacaa tcctcaagtt ttaattgatt 4860 ttaaatattt ttcaatacaa cagtttaggt ttaagatgac caatgacaat gaccaccttt 4920 gcagaaagta aactgattga ataaataaat ctccgttttc ttcaatttat ttcagtgtaa 4980 tgaaaaagtt gcttagtatt tatgaggaaa ttcttcttcc tggcaggtag cttaaagagt 5040 ggggtatata gagccacaac acatgtttat tttgcttggc tgcagttgaa aaatagaaat 5100 tagtgccctt ttgtgacctc tcattccaag attgtcaatt aaaaatgagt ttaaaatgtt 5160 taacttgtga tcgagaccta catgcatgtc ttgatattgt gtaactataa tagagactct 5220 ttaaggagaa tcttaaaaaa aaaaaaacgt ttctcactgt cttaaataga atttttaaat 5280 agtatatatt cagtggcatt ttggagaaca aagtgaattt acttcgactt cttaaatttt 5340 tgtaaaagac tataagttta gacatctttc tcattcaaat ttaaagatat ctttctcctc 5400 ttgatcaatc tatcaatatt gatagaagtc acactagtat ataccattta atacatttac 5460 actttcttat ttaagaagat attgaatgca aaataattga catatagaac tttacaaaca 5520 tatgtccaag gactctaaat tgagactctt ccacatgtac aatctcatca tcctgaagcc 5580 tataatgaag aaaaagatct agaaactgag ttgtggagct gactctaatc aaatgtgatg 5640 attggaatta gaccatttgg cctttgaact ttcataggaa aaatgaccca acatttctta 5700 gcatgagcta cctcatctct agaagctggg atggacttac tattcttgtt tatattttag 5760 atactgaaag gtgctatgct tctgttatta ttccaagact ggagataggc agggctaaaa 5820 aggtattatt atttttcctt taatgatggt gctaaaattc ttcctataaa attccttaaa 5880 aataaagatg gtttaatcac taccattgtg aaaacataac tgttagactt cccgtttctg 5940 aaagaaagag catcgttcca atgcttgttc actgttcctc tgtcatactg tatctggaat 6000 gctttgtaat acttgcatgc ttcttagacc agaacatgta ggtccccttg tgtctcaata 6060 cttttttttt cttaattgca tttgttggct ctattttaat ttttttcttt taaaataaac 6120 agctgggacc atcccaaaag acaagccatg catacaactt tggtcatgta tctctgcaaa 6180 gcatcaaatt aaatgcacgc ttttgtcatg tcagtggttt ttgttttgtg aaattccttt 6240 gaccatatta gatctatttc atttccaata gtgaaaagga gatgtggtgg tatactttgt 6300 ttgccatttg tttaaaagat acaacggata ccttctatca tgtatgtact ggcttataaa 6360 tgaaaatcta tctacaacat tacccacaaa ggcaacatga caccaattat cactgcctct 6420 gcccttaaaa atgtcagagt agtattattg ataaaaaggg caagcaatag atttttcatg 6480 actgaataaa ctgtaataat aaaacatatg tctcaaagtg tatcacatat gaatttagcc 6540 taattgtttt cagtttcatt ctcaatattt agtttacaac atcattttcc cctaaactgg 6600 ttatattttg acctgtatat cttaaatttg agtatttata tgcctaaata catgtgtgag 6660 ttttgtttga cttccaagtc caaactataa gattatataa gttcatatag atgaatcaga 6720 aatatgtggt aatactatta agtcacaaac actaacaatt tccaactata gaaataacag 6780 ttcttatttg gattttggga atgctaccaa taaaagcctg cccagacca 6829 <210> 195 <211> 1769 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1769) <223> CSF3 mRNA <400> 195 agtcgtggcc ccaggtaatt tcctcccagg cctccatggg gttatgtata aaggcccccc 60 tagagctggg ccccaaaaca gcccggagcc tgcagcccag ccccacccag acccatggct 120 ggacctgcca cccagagccc catgaagctg atgggtgagt gtcttggccc aggatgggag 180 agccgcctgc cctggcatgg gagggaggct ggtgtgacag aggggctggg gatccccgtt 240 ctgggaatgg ggattaaagg cacccagtgt ccccgagagg gcctcaggtg gtagggaaca 300 gcatgtctcc tgagcccgct ctgtccccag ccctgcagct gctgctgtgg cacagtgcac 360 tctggacagt gcaggaagcc acccccctgg gccctgccag ctccctgccc cagagcttcc 420 tgctcaagtg cttagagcaa gtgaggaaga tccagggcga tggcgcagcg ctccaggaga 480 agctgtgtgc cacctacaag ctgtgccacc ccgaggagct ggtgctgctc ggacactctc 540 tgggcatccc ctgggctccc ctgagcagct gccccagcca ggccctgcag ctggcaggct 600 gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag gccctggaag 660 ggatctcccc cgagttgggt cccaccttgg acacactgca gctggacgtc gccgactttg 720 ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg cagcccaccc 780 agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg gtcctggttg 840 cctcccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac cttgcccagc 900 cctgagccaa gccctcccca tcccatgtat ttatctctat ttaatattta tgtctattta 960 agcctcatat ttaaagacag ggaagagcag aacggagccc caggcctctg tgtccttccc 1020 tgcatttctg agtttcattc tcctgcctgt agcagtgaga aaaagctcct gtcctcccat 1080 cccctggact gggaggtaga taggtaaata ccaagtattt attactatga ctgctcccca 1140 gccctggctc tgcaatgggc actgggatga gccgctgtga gcccctggtc ctgagggtcc 1200 ccacctggga cccttgagag tatcaggtct cccacgtggg agacaagaaa tccctgttta 1260 atatttaaac agcagtgttc cccatctggg tccttgcacc cctcactctg gcctcagccg 1320 actgcacagc ggcccctgca tccccttggc tgtgaggccc ctggacaagc agaggtggcc 1380 agagctggga ggcatggccc tggggtccca cgaatttgct ggggaatctc gtttttcttc 1440 ttaagacttt tgggacatgg tttgactccc gaacatcacc gacgcgtctc ctgtttttct 1500 gggtggcctc gggacacctg ccctgccccc acgagggtca ggactgtgac tctttttagg 1560 gccaggcagg tgcctggaca tttgccttgc tggacgggga ctggggatgt gggagggagc 1620 agacaggagg aatcatgtca ggcctgtgtg tgaaaggaag ctccactgtc accctccacc 1680 tcttcacccc ccactcacca gtgtcccctc cactgtcaca ttgtaactga acttcaggat 1740 aataaagtgt ttgcctccaa aaaaaaaaa 1769 <210> 196 <211> 2358 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2358) <223> CTCF mRNA <400> 196 aaactcacac aacaactctt ccccgctgag aggagacagc cagtgcgact ccaccctcca 60 gctcgacggc agccgccccg gccgacagcc ccgagacgac agcccggcgc gtcccggtcc 120 ccacctccga ccaccgccag cgctccaggc cccgccgctc cccgctcgcc gccaccgcgc 180 cctccgctcc gcccgcagtg ccaaccatga ccgccgccag tatgggcccc gtccgcgtcg 240 ccttcgtggt cctcctcgcc ctctgcagcc ggccggccgt cggccagaac tgcagcgggc 300 cgtgccggtg cccggacgag ccggcgccgc gctgcccggc gggcgtgagc ctcgtgctgg 360 acggctgcgg ctgctgccgc gtctgcgcca agcagctggg cgagctgtgc accgagcgcg 420 acccctgcga cccgcacaag ggcctcttct gtgacttcgg ctccccggcc aaccgcaaga 480 tcggcgtgtg caccgccaaa gatggtgctc cctgcatctt cggtggtacg gtgtaccgca 540 gcggagagtc cttccagagc agctgcaagt accagtgcac gtgcctggac ggggcggtgg 600 gctgcatgcc cctgtgcagc atggacgttc gtctgcccag ccctgactgc cccttcccga 660 ggagggtcaa gctgcccggg aaatgctgcg aggagtgggt gtgtgacgag cccaaggacc 720 aaaccgtggt tgggcctgcc ctcgcggctt accgactgga agacacgttt ggcccagacc 780 caactatgat tagagccaac tgcctggtcc agaccacaga gtggagcgcc tgttccaaga 840 cctgtgggat gggcatctcc acccgggtta ccaatgacaa cgcctcctgc aggctagaga 900 agcagagccg cctgtgcatg gtcaggcctt gcgaagctga cctggaagag aacattaaga 960 agggcaaaaa gtgcatccgt actcccaaaa tctccaagcc tatcaagttt gagctttctg 1020 gctgcaccag catgaagaca taccgagcta aattctgtgg agtatgtacc gacggccgat 1080 gctgcacccc ccacagaacc accaccctgc cggtggagtt caagtgccct gacggcgagg 1140 tcatgaagaa gaacatgatg ttcatcaaga cctgtgcctg ccattacaac tgtcccggag 1200 acaatgacat ctttgaatcg ctgtactaca ggaagatgta cggagacatg gcatgaagcc 1260 agagagtgag agacattaac tcattagact ggaacttgaa ctgattcaca tctcattttt 1320 ccgtaaaaat gatttcagta gcacaagtta tttaaatctg tttttctaac tgggggaaaa 1380 gattcccacc caattcaaaa cattgtgcca tgtcaaacaa atagtctatc aaccccagac 1440 actggtttga agaatgttaa gacttgacag tggaactaca ttagtacaca gcaccagaat 1500 gtatattaag gtgtggcttt aggagcagtg ggagggtacc agcagaaagg ttagtatcat 1560 cagatagcat cttatacgag taatatgcct gctatttgaa gtgtaattga gaaggaaaat 1620 tttagcgtgc tcactgacct gcctgtagcc ccagtgacag ctaggatgtg cattctccag 1680 ccatcaagag actgagtcaa gttgttcctt aagtcagaac agcagactca gctctgacat 1740 tctgattcga atgacactgt tcaggaatcg gaatcctgtc gattagactg gacagcttgt 1800 ggcaagtgaa tttgcctgta acaagccaga ttttttaaaa tttatattgt aaatattgtg 1860 tgtgtgtgtg tgtgtgtata tatatatata tgtacagtta tctaagttaa tttaaagttg 1920 tttgtgcctt tttatttttg tttttaatgc tttgatattt caatgttagc ctcaatttct 1980 gaacaccata ggtagaatgt aaagcttgtc tgatcgttca aagcatgaaa tggatactta 2040 tatggaaatt ctgctcagat agaatgacag tccgtcaaaa cagattgttt gcaaagggga 2100 ggcatcagtg tccttggcag gctgatttct aggtaggaaa tgtggtagcc tcacttttaa 2160 tgaacaaatg gcctttatta aaaactgagt gactctatat agctgatcag ttttttcacc 2220 tggaagcatt tgtttctact ttgatatgac tgtttttcgg acagtttatt tgttgagagt 2280 gtgaccaaaa gttacatgtt tgcacctttc tagttgaaaa taaagtgtat attttttcta 2340 taaaaaaaaa aaaaaaaa 2358 <210> 197 <211> 3661 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3661) <223> CTNNB1 mRNA <400> 197 aagcctctcg gtctgtggca gcagcgttgg cccggccccg ggagcggaga gcgaggggag 60 gcggagacgg aggaaggtct gaggagcagc ttcagtcccc gccgagccgc caccgcaggt 120 cgaggacggt cggactcccg cggcgggagg agcctgttcc cctgagggta tttgaagtat 180 accatacaac tgttttgaaa atccagcgtg gacaatggct actcaagctg atttgatgga 240 gttggacatg gccatggaac cagacagaaa agcggctgtt agtcactggc agcaacagtc 300 ttacctggac tctggaatcc attctggtgc cactaccaca gctccttctc tgagtggtaa 360 aggcaatcct gaggaagagg atgtggatac ctcccaagtc ctgtatgagt gggaacaggg 420 attttctcag tccttcactc aagaacaagt agctgatatt gatggacagt atgcaatgac 480 tcgagctcag agggtacgag ctgctatgtt ccctgagaca ttagatgagg gcatgcagat 540 cccatctaca cagtttgatg ctgctcatcc cactaatgtc cagcgtttgg ctgaaccatc 600 acagatgctg aaacatgcag ttgtaaactt gattaactat caagatgatg cagaacttgc 660 cacacgtgca atccctgaac tgacaaaact gctaaatgac gaggaccagg tggtggttaa 720 taaggctgca gttatggtcc atcagctttc taaaaaggaa gcttccagac acgctatcat 780 gcgttctcct cagatggtgt ctgctattgt acgtaccatg cagaatacaa atgatgtaga 840 aacagctcgt tgtaccgctg ggaccttgca taacctttcc catcatcgtg agggcttact 900 ggccatcttt aagtctggag gcattcctgc cctggtgaaa atgcttggtt caccagtgga 960 ttctgtgttg ttttatgcca ttacaactct ccacaacctt ttattacatc aagaaggagc 1020 taaaatggca gtgcgtttag ctggtgggct gcagaaaatg gttgccttgc tcaacaaaac 1080 aaatgttaaa ttcttggcta ttacgacaga ctgccttcaa attttagctt atggcaacca 1140 agaaagcaag ctcatcatac tggctagtgg tggaccccaa gctttagtaa atataatgag 1200 gacctatact tacgaaaaac tactgtggac cacaagcaga gtgctgaagg tgctatctgt 1260 ctgctctagt aataagccgg ctattgtaga agctggtgga atgcaagctt taggacttca 1320 cctgacagat ccaagtcaac gtcttgttca gaactgtctt tggactctca ggaatctttc 1380 agatgctgca actaaacagg aagggatgga aggtctcctt gggactcttg ttcagcttct 1440 gggttcagat gatataaatg tggtcacctg tgcagctgga attctttcta acctcacttg 1500 caataattat aagaacaaga tgatggtctg ccaagtgggt ggtatagagg ctcttgtgcg 1560 tactgtcctt cgggctggtg acagggaaga catcactgag cctgccatct gtgctcttcg 1620 tcatctgacc agccgacacc aagaagcaga gatggcccag aatgcagttc gccttcacta 1680 tggactacca gttgtggtta agctcttaca cccaccatcc cactggcctc tgataaaggc 1740 tactgttgga ttgattcgaa atcttgccct ttgtcccgca aatcatgcac ctttgcgtga 1800 gcagggtgcc attccacgac tagttcagtt gcttgttcgt gcacatcagg atacccagcg 1860 ccgtacgtcc atgggtggga cacagcagca atttgtggag ggggtccgca tggaagaaat 1920 agttgaaggt tgtaccggag cccttcacat cctagctcgg gatgttcaca accgaattgt 1980 tatcagagga ctaaatacca ttccattgtt tgtgcagctg ctttattctc ccattgaaaa 2040 catccaaaga gtagctgcag gggtcctctg tgaacttgct caggacaagg aagctgcaga 2100 agctattgaa gctgagggag ccacagctcc tctgacagag ttacttcact ctaggaatga 2160 aggtgtggcg acatatgcag ctgctgtttt gttccgaatg tctgaggaca agccacaaga 2220 ttacaagaaa cggctttcag ttgagctgac cagctctctc ttcagaacag agccaatggc 2280 ttggaatgag actgctgatc ttggacttga tattggtgcc cagggagaac cccttggata 2340 tcgccaggat gatcctagct atcgttcttt tcactctggt ggatatggcc aggatgcctt 2400 gggtatggac cccatgatgg aacatgagat gggtggccac caccctggtg ctgactatcc 2460 agttgatggg ctgccagatc tggggcatgc ccaggacctc atggatgggc tgcctccagg 2520 tgacagcaat cagctggcct ggtttgatac tgacctgtaa atcatccttt aggtaagaag 2580 ttttaaaaag ccagtttggg taaaatactt ttactctgcc tacagaactt cagaaagact 2640 tggttggtag ggtgggagtg gtttaggcta tttgtaaatc tgccacaaaa acaggtatat 2700 actttgaaag gagatgtctt ggaacattgg aatgttctca gatttctggt tgttatgtga 2760 tcatgtgtgg aagttattaa ctttaatgtt ttttgccaca gcttttgcaa cttaatactc 2820 aaatgagtaa catttgctgt tttaaacatt aatagcagcc tttctctctt tatacagctg 2880 tattgtctga acttgcattg tgattggcct gtagagttgc tgagagggct cgaggggtgg 2940 gctggtatct cagaaagtgc ctgacacact aaccaagctg agtttcctat gggaacaatt 3000 gaagtaaact ttttgttctg gtcctttttg gtcgaggagt aacaatacaa atggattttg 3060 ggagtgactc aagaagtgaa gaatgcacaa gaatggatca caagatggaa tttatcaaac 3120 cctagccttg cttgttaaat tttttttttt ttttttttaa gaatatctgt aatggtactg 3180 actttgcttg ctttgaagta gctctttttt tttttttttt tttttttttg cagtaactgt 3240 tttttaagtc tctcgtagtg ttaagttata gtgaatactg ctacagcaat ttctaatttt 3300 taagaattga gtaatggtgt agaacactaa ttcataatca ctctaattaa ttgtaatctg 3360 aataaagtgt aacaattgtg tagccttttt gtataaaata gacaaataga aaatggtcca 3420 attagtttcc tttttaatat gcttaaaata agcaggtgga tctatttcat gtttttgatc 3480 aaaaactatt tgggatatgt atgggtaggg taaatcagta agaggtgtta tttggaacct 3540 tgttttggac agtttaccag ttgcctttta tcccaaagtt gttgtaacct gctgtgatac 3600 gatgcttcaa gagaaaatgc ggttataaaa aatggttcag aattaaactt ttaattcatt 3660 c 3661 <210> 198 <211> 1629 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1629) <223> CTSK mRNA <400> 198 acactttgct gccgaaacga agccagacaa cagatttcca tcagcaggat gtgggggctc 60 aaggttctgc tgctacctgt ggtgagcttt gctctgtacc ctgaggagat actggacacc 120 cactgggagc tatggaagaa gacccacagg aagcaatata acaacaaggt ggatgaaatc 180 tctcggcgtt taatttggga aaaaaacctg aagtatattt ccatccataa ccttgaggct 240 tctcttggtg tccatacata tgaactggct atgaaccacc tgggggacat gaccagtgaa 300 gaggtggttc agaagatgac tggactcaaa gtacccctgt ctcattcccg cagtaatgac 360 accctttata tcccagaatg ggaaggtaga gccccagact ctgtcgacta tcgaaagaaa 420 ggatatgtta ctcctgtcaa aaatcagggt cagtgtggtt cctgttgggc ttttagctct 480 gtgggtgccc tggagggcca actcaagaag aaaactggca aactcttaaa tctgagtccc 540 cagaacctag tggattgtgt gtctgagaat gatggctgtg gagggggcta catgaccaat 600 gccttccaat atgtgcagaa gaaccggggt attgactctg aagatgccta cccatatgtg 660 ggacaggaag agagttgtat gtacaaccca acaggcaagg cagctaaatg cagagggtac 720 agagagatcc ccgaggggaa tgagaaagcc ctgaagaggg cagtggcccg agtgggacct 780 gtctctgtgg ccattgatgc aagcctgacc tccttccagt tttacagcaa aggtgtgtat 840 tatgatgaaa gctgcaatag cgataatctg aaccatgcag ttttggcagt gggatatgga 900 atccagaagg gaaacaagca ctggataatt aaaaacagct ggggagaaaa ctggggaaac 960 aaaggatata tcctcatggc tcgaaataag aacaacgcct gtggcattgc caacctggcc 1020 agcttcccca agatgtgact ccagccagcc aaatccatcc tgctcttcca tttcttccac 1080 gatggtgcag tgtaacgatg cactttggaa gggagttggt gtgctatttt tgaagcagat 1140 gtggtgatac tgagattgtc tgttcagttt ccccatttgt ttgtgcttca aatgatcctt 1200 cctactttgc ttctctccac ccatgacctt tttcactgtg gccatcagga ctttccctga 1260 cagctgtgta ctcttaggct aagagatgtg actacagcct gcccctgact gtgttgtccc 1320 agggctgatg ctgtacaggt acaggctgga gattttcaca taggttagat tctcattcac 1380 gggactagtt agctttaagc accctagagg actagggtaa tctgacttct cacttcctaa 1440 gttcccttct atatcctcaa ggtagaaatg tctatgtttt ctactccaat tcataaatct 1500 attcataagt ctttggtaca agtttacatg ataaaaagaa atgtgatttg tcttcccttc 1560 tttgcacttt tgaaataaag tatttatctc ctgtctacag tttaataaat agcatctagt 1620 acacattca 1629 <210> 199 <211> 1184 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1184) <223> CXCL1 mRNA <400> 199 cacagagccc gggccgcagg cacctcctcg ccagctcttc cgctcctctc acagccgcca 60 gacccgcctg ctgagcccca tggcccgcgc tgctctctcc gccgccccca gcaatccccg 120 gctcctgcga gtggcactgc tgctcctgct cctggtagcc gctggccggc gcgcagcagg 180 agcgtccgtg gccactgaac tgcgctgcca gtgcttgcag accctgcagg gaattcaccc 240 caagaacatc caaagtgtga acgtgaagtc ccccggaccc cactgcgccc aaaccgaagt 300 catagccaca ctcaagaatg ggcggaaagc ttgcctcaat cctgcatccc ccatagttaa 360 gaaaatcatc gaaaagatgc tgaacagtga caaatccaac tgaccagaag ggaggaggaa 420 gctcactggt ggctgttcct gaaggaggcc ctgcccttat aggaacagaa gaggaaagag 480 agacacagct gcagaggcca cctggattgt gcctaatgtg tttgagcatc gcttaggaga 540 agtcttctat ttatttattt attcattagt tttgaagatt ctatgttaat attttaggtg 600 taaaataatt aagggtatga ttaactctac ctgcacactg tcctattata ttcattcttt 660 ttgaaatgtc aaccccaagt tagttcaatc tggattcata tttaatttga aggtagaatg 720 ttttcaaatg ttctccagtc attatgttaa tatttctgag gagcctgcaa catgccagcc 780 actgtgatag aggctggcgg atccaagcaa atggccaatg agatcattgt gaaggcaggg 840 gaatgtatgt gcacatctgt tttgtaactg tttagatgaa tgtcagttgt tatttattga 900 aatgatttca cagtgtgtgg tcaacatttc tcatgttgaa actttaagaa ctaaaatgtt 960 ctaaatatcc cttggacatt ttatgtcttt cttgtaaggc atactgcctt gtttaatggt 1020 agttttacag tgtttctggc ttagaacaaa ggggcttaat tattgatgtt ttcatagaga 1080 atataaaaat aaagcactta tagaaaaaac tcgtttgatt tttgggggga aacaagggct 1140 acctttactg gaaaatctgg tgatttataa aaaaaaaaaa aaaa 1184 <210> 200 <211> 2436 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2436) <223> CXCL5 mRNA <400> 200 acagtgctcc ggatcctcca atcttcgctc ctccaatctc cgctcctcca cccagttcag 60 gaacccgcga ccgctcgcag cgctctcttg accactatga gcctcctgtc cagccgcgcg 120 gcccgtgtcc ccggtccttc gagctccttg tgcgcgctgt tggtgctgct gctgctgctg 180 acgcagccag ggcccatcgc cagcgctggt cctgccgctg ctgtgttgag agagctgcgt 240 tgcgtttgtt tacagaccac gcaaggagtt catcccaaaa tgatcagtaa tctgcaagtg 300 ttcgccatag gcccacagtg ctccaaggtg gaagtggtag cctccctgaa gaacgggaag 360 gaaatttgtc ttgatccaga agcccctttt ctaaagaaag tcatccagaa aattttggac 420 ggtggaaaca aggaaaactg attaagagaa atgagcacgc atggaaaagt ttcccagtct 480 tcagcagaga agttttctgg aggtctctga acccagggaa gacaagaagg aaagattttg 540 ttgttgtttg tttatttgtt tttccagtag ttagctttct tcctggattc ctcactttga 600 agagtgtgag gaaaacctat gtttgccgct taagctttca gctcagctaa tgaagtgttt 660 agcatagtac ctctgctatt tgctgttatt ttatctgcta tgctattgaa gttttggcaa 720 ttgactatag tgtgagccag gaatcactgg ctgttaatct ttcaaagtgt cttgaattgt 780 aggtgactat tatatttcca agaaatattc cttaagatat taactgagaa ggctgtggat 840 ttaatgtgga aatgatgttt cataagaatt ctgttgatgg aaatacactg ttatcttcac 900 ttttataaga aataggaaat attttaatgt ttcttgggga atatgttaga gaatttcctt 960 actcttgatt gtgggatact atttaattat ttcactttag aaagctgagt gtttcacacc 1020 ttatctatgt agaatatatt tccttattca gaatttctaa aagtttaagt tctatgaggg 1080 ctaatatctt atcttcctat aattttagac attctttatc tttttagtat ggcaaactgc 1140 catcatttac ttttaaactt tgattttata tgctatttat taagtatttt attaggagta 1200 ccataattct ggtagctaaa tatatatttt agatagatga agaagctaga aaacaggcaa 1260 attcctgact gctagtttat atagaaatgt attcttttag tttttaaagt aaaggcaaac 1320 ttaacaatga cttgtactct gaaagttttg gaaacgtatt caaacaattt gaatataaat 1380 ttatcattta gttataaaaa tatatagcga catcctcgag gccctagcat ttctccttgg 1440 ataggggacc agagagagct tggaatgtta aaaacaaaac aaaacaaaaa aaaacaagga 1500 gaagttgtcc aagggatgtc aattttttat ccctctgtat gggttagatt ttccaaaatc 1560 ataatttgaa gaaggccagc atttatggta gaatatataa ttatatataa ggtggccacg 1620 ctggggcaag ttccctcccc actcacagct ttggcccctt tcacagagta gaacctgggt 1680 tagaggattg cagaagacga gcgggagcgg ggagggcagg gaagatgcct gtcgggtttt 1740 tagcacagtt catttcactg ggattttgaa gcatttctgt ctgaatgtaa agcctgttct 1800 agtcctggtg ggacacactg gggttggggg tgggggaaga tgcggtaatg aaaccggtta 1860 gtcagtgttg tcttaatatc cttgataatg ctgtaaagtt tatttttaca aatatttctg 1920 tttaagctat ttcacctttg tttggaaatc cttccctttt aaagagaaaa tgtgacactt 1980 gtgaaaaggc ttgtaggaaa gctcctccct ttttttcttt aaacctttaa atgacaaacc 2040 taggtaatta atggttgtga atttctattt ttgctttgtt tttaatgaac atttgtcttt 2100 cagaatagga ttctgtgata atatttaaat ggcaaaaaca aaacataatt ttgtgcaatt 2160 aacaaagcta ctgcaagaaa aataaaacat ttcttggtaa aaacgtatgt atttatatat 2220 tatatattta tatataatat atattatata tttagcattg ctgagctttt tagatgccta 2280 ttgtgtatct tttaaaggtt ttgaccattt tgttatgagt aattacatat atattacatt 2340 cactatatta aaattgtact tttttactat gtgtctcatt ggttcatagt ctttattttg 2400 tcctttgaat aaacattaaa agatttctaa acttca 2436 <210> 201 <211> 1537 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1537) <223> CXCL6 mRNA <400> 201 caaagtgctc tgtatcctcc agtctccgcg cctccaccca gctcaggaac ccgcgaaccc 60 tctcttgacc actatgagcc tcccgtccag ccgcgcggcc cgtgtcccgg gtccttcggg 120 ctccttgtgc gcgctgctcg cgctgctgct cctgctgacg ccgccggggc ccctcgccag 180 cgctggtcct gtctctgctg tgctgacaga gctgcgttgc acttgtttac gcgttacgct 240 gagagtaaac cccaaaacga ttggtaaact gcaggtgttc cccgcaggcc cgcagtgctc 300 caaggtggaa gtggtagcct ccctgaagaa cgggaagcaa gtttgtctgg acccggaagc 360 cccttttcta aagaaagtca tccagaaaat tttggacagt ggaaacaaga aaaactgagt 420 aacaaaaaag accatgcatc ataaaattgc ccagtcttca gcggagcagt tttctggaga 480 tccctggacc cagtaagaat aagaaggaag ggttggtttt tttccatttt ctacatggat 540 tccctacttt gaagagtgtg ggggaaagcc tacgcttctc cctgaagttt acagctcagc 600 taatgaagta ctaatatagt atttccacta tttactgtta ttttacctga taagttattg 660 aaccctttgg caattgacca tattgtgagc aaagaatcac tggttattag tctttcaatg 720 aatattgaat tgaagataac tattgtattt ctatcataca ttccttaaag tcttaccgaa 780 aaggctgtgg atttcgtatg gaaataatgt tttattagtg tgctgttgag ggaggtatcc 840 tgttgttctt actcactctt ctcataaaat aggaaatatt ttagttctgt ttcttgggga 900 atatgttact ctttacccta ggatgctatt taagttgtac tgtattagaa cactgggtgt 960 gtcataccgt tatctgtgca gaatatattt ccttattcag aatttctaaa aatttaagtt 1020 ctgtaagggc taatatattc tcttcctatg gttttagacg tttgatgtct tcttagtatg 1080 gcataatgtc atgatttact cattaaactt tgattttgta tgctattttt tcactatagg 1140 atgactataa ttctggtcac taaatataca ctttagatag atgaagaagc ccaaaaacag 1200 ataaattcct gattgctaat ttacatagaa atgtattctc ttggtttttt aaataaaagc 1260 aaaattaaca atgatctgtg ctctgaaagt tttgaaaata tatttgaaca atttgaatat 1320 aaattcatca tttagtcctc aaaatatata tagcattgct aagattttca gatatctatt 1380 gtggatcttt taaaggtttt gaccattttg ttatgaggaa ttatacatgt atcacattca 1440 ctatattaaa attgcacttt tattttttcc tgtgtgtcat gttggttttt ggtacttgta 1500 ttgtcatttg gagaaacaat aaaagatttc taaacca 1537 <210> 202 <211> 3395 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3395) <223> DUSP6 mRNA <400> 202 agggcttttg tgcatgctaa ttgcgccatt ggtgcgcaaa agttccgacg cgaagtgtga 60 actctcaaca gaaggaaaca tgagacaact gaagtgccct ggtttatgtg ccctgctcct 120 cctccgctgc cgcctcccct tctttctcct tcctcccgcc gagcccgctg ttgcagcttg 180 tttgcactgg ggcttatccg gagcggaaat tcctttccgt ttttgtgaat gacaaactca 240 ttaacaattc atcaacacaa cctgttccag ccggcccgtc cccacggcaa cagccccttc 300 cgcagcacgc tcattggctg gcccggagaa tgtatccatt gagacgctcg ctgtttgtat 360 ccattgagga gctgcctcgc gcagggggtg tgcgaggctg agtccaagag atagcaaatc 420 gagtcttaaa taatccgggg agaaagacgc ccgggtagat ttgaggtgca gccttggagg 480 gagggattag aagccgctag actttttttc ctcccctctc agtagcacgg agtccgaatt 540 aattggattt cattcactgg ggaggaacaa aaactatctg ggcagcttca ttgagagaga 600 ttcattgaca ctaagagcca gcggctgcag ctgggtgcag agagaacctc cggctttact 660 tctgtctcgt ctgccccaac cgctagcctc ggcttgggta aggcgaggcg gaattaaacc 720 ccgctccgag agcggcagct tcgcgcgcgg tgcgctcggc ctatgcctgc cccgaggggc 780 gtctggtagg caccccgccc tctcccgcag ctcgaccccc atgatagata cgctcagacc 840 cgtgcccttc gcgtcggaaa tggcgatcag caagacggtg gcgtggctca acgagcagct 900 ggagctgggc aacgagcggc tgctgctgat ggactgccgg ccgcaggagc tatacgagtc 960 gtcgcacatc gagtcggcca tcaacgtggc catcccgggc atcatgctgc ggcgcctgca 1020 gaagggtaac ctgccggtgc gcgcgctctt cacgcgcggc gaggaccggg accgcttcac 1080 ccggcgctgt ggcaccgaca cagtggtgct ctacgacgag agcagcagcg actggaacga 1140 gaatacgggc ggcgagtcgg tgctcgggct gctgctcaag aagctcaagg acgagggctg 1200 ccgggcgttc tacctggaag gtggcttcag taagttccaa gccgagttct ccctgcattg 1260 cgagaccaat ctagacggct cgtgtagcag cagctcgccg ccgttgccag tgctggggct 1320 cgggggcctg cggatcagct ctgactcttc ctcggacatc gagtctgacc ttgaccgaga 1380 ccccaatagt gcaacagact cggatggtag tccgctgtcc aacagccagc cttccttccc 1440 agtggagatc ttgcccttcc tctacttggg ctgtgccaaa gactccacca acttggacgt 1500 gttggaggaa ttcggcatca agtacatctt gaacgtcacc cccaatttgc cgaatctctt 1560 tgagaacgca ggagagttta aatacaagca aatccccatc tcggatcact ggagccaaaa 1620 cctgtcccag tttttccctg aggccatttc tttcatagat gaagcccggg gcaagaactg 1680 tggtgtcttg gtacattgct tggctggcat tagccgctca gtcactgtga ctgtggctta 1740 ccttatgcag aagctcaatc tgtcgatgaa cgatgcctat gacattgtca aaatgaaaaa 1800 atccaacata tcccctaact tcaacttcat gggtcagctg ctggacttcg agaggacgct 1860 gggactcagc agcccatgtg acaacagggt tccagcacag cagctgtatt ttaccacccc 1920 ttccaaccag aatgtatacc aggtggactc tctgcaatct acgtgaaaga ccccacaccc 1980 ctccttgctg gaatgtgtct ggcccttcag cagtttctct tggcagcatc agctgggctg 2040 ctttctttgt gtgtggcccc aggtgtcaaa atgacaccag ctgtctgtac tagacaaggt 2100 taccaagtgc ggaattggtt aatactaaca gagagatttg ctccattctc tttggaataa 2160 caggacatgc tgtatagata caggcagtag gtttgctctg tacccatgtg tacagcctac 2220 ccatgcaggg actgggattc gaggacttcc aggcgcatag ggtagaacca aatgataggg 2280 taggagcatg tgttctttag ggccttgtaa ggctgtttcc ttttgcatct ggaactgact 2340 atataattgt cttcaatgaa gactaattca attttgcata tagaggagcc aaagagagat 2400 ttcagctctg tatttgtggt atcagtttgg aaaaaaaaat ctgatactcc atttgattat 2460 tgtaaatatt tgatcttgaa tcacttgaca gtgtttgttt gaattgtgtt tgttttttcc 2520 tttgatgggc ttaaaagaaa ttatccaaag ggagaaagag cagtatgcca cttcttaaaa 2580 cagaacaaaa caaaaaaaga aaattgtgct cttttctaat ccaaagggta tatttgcagc 2640 atgcttgact ttaccaattc tgatgacatc tttacggaca ctattatcac taagaccttg 2700 ttatggcgaa gtctttagtc tttttcatgt attttcctca tgattttttc tctttatgta 2760 gtttgactat gccttacctt tgtaaatatt tttgcttgtg ttgtcgcaaa ggggataatc 2820 tgggaaagac accaaatcat gggctcactt taaaaaaaga aagaataaaa aaaccttcag 2880 ctgtgctaaa cagtatatta cctctgtata aaattcttca gggagtgtca cctcaaatgc 2940 aatactttgg gttggtttct ttcctttaaa aaaatttgta taaaactgga agtgtgtgtg 3000 tgtgagcatg ggtacccatt tgataagaga aatgcatttg attgtgaaga agggagagtt 3060 aaattctcca ttatgttcgt ggtgtaaagt ttagagctgg aatttattat aagaatgtaa 3120 aaccttaaat tattaataaa taactatttt ggctattgaa tgtgtgtttt taaaaactca 3180 gttataccta tgtgtgaagt gacacatttt agaacttttt cattcaggga ttgattttga 3240 cttgtaggca tagtagggca aggttctttt aagcttttcc tagaacgttt ttcagcagca 3300 gtttatgaaa ttcatcgttt gccacgaata aagatgacat cctagaatgg accgactgta 3360 ccgtgtatat gaacaatacc tcttatgagt atagt 3395 <210> 203 <211> 6369 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6369) <223> EGFR mRNA <400> 203 gtccgggcag cccccggcgc agcgcggccg cagcagcctc cgccccccgc acggtgtgag 60 cgcccgacgc ggccgaggcg gccggagtcc cgagctagcc ccggcggccg ccgccgccca 120 gaccggacga caggccacct cgtcggcgtc cgcccgagtc cccgcctcgc cgccaacgcc 180 acaaccaccg cgcacggccc cctgactccg tccagtattg atcgggagag ccggagcgag 240 ctcttcgggg agcagcgatg cgaccctccg ggacggccgg ggcagcgctc ctggcgctgc 300 tggctgcgct ctgcccggcg agtcgggctc tggaggaaaa gaaagtttgc caaggcacga 360 gtaacaagct cacgcagttg ggcacttttg aagatcattt tctcagcctc cagaggatgt 420 tcaataactg tgaggtggtc cttgggaatt tggaaattac ctatgtgcag aggaattatg 480 atctttcctt cttaaagacc atccaggagg tggctggtta tgtcctcatt gccctcaaca 540 cagtggagcg aattcctttg gaaaacctgc agatcatcag aggaaatatg tactacgaaa 600 attcctatgc cttagcagtc ttatctaact atgatgcaaa taaaaccgga ctgaaggagc 660 tgcccatgag aaatttacag gaaatcctgc atggcgccgt gcggttcagc aacaaccctg 720 ccctgtgcaa cgtggagagc atccagtggc gggacatagt cagcagtgac tttctcagca 780 acatgtcgat ggacttccag aaccacctgg gcagctgcca aaagtgtgat ccaagctgtc 840 ccaatgggag ctgctggggt gcaggagagg agaactgcca gaaactgacc aaaatcatct 900 gtgcccagca gtgctccggg cgctgccgtg gcaagtcccc cagtgactgc tgccacaacc 960 agtgtgctgc aggctgcaca ggcccccggg agagcgactg cctggtctgc cgcaaattcc 1020 gagacgaagc cacgtgcaag gacacctgcc ccccactcat gctctacaac cccaccacgt 1080 accagatgga tgtgaacccc gagggcaaat acagctttgg tgccacctgc gtgaagaagt 1140 gtccccgtaa ttatgtggtg acagatcacg gctcgtgcgt ccgagcctgt ggggccgaca 1200 gctatgagat ggaggaagac ggcgtccgca agtgtaagaa gtgcgaaggg ccttgccgca 1260 aagtgtgtaa cggaataggt attggtgaat ttaaagactc actctccata aatgctacga 1320 atattaaaca cttcaaaaac tgcacctcca tcagtggcga tctccacatc ctgccggtgg 1380 catttagggg tgactccttc acacatactc ctcctctgga tccacaggaa ctggatattc 1440 tgaaaaccgt aaaggaaatc acagggtttt tgctgattca ggcttggcct gaaaacagga 1500 cggacctcca tgcctttgag aacctagaaa tcatacgcgg caggaccaag caacatggtc 1560 agttttctct tgcagtcgtc agcctgaaca taacatcctt gggattacgc tccctcaagg 1620 agataagtga tggagatgtg ataatttcag gaaacaaaaa tttgtgctat gcaaatacaa 1680 taaactggaa aaaactgttt gggacctccg gtcagaaaac caaaattata agcaacagag 1740 gtgaaaacag ctgcaaggcc acaggccagg tctgccatgc cttgtgctcc cccgagggct 1800 gctggggccc ggagcccagg gactgcgtct cttgccggaa tgtcagccga ggcagggaat 1860 gcgtggacaa gtgcaacctt ctggagggtg agccaaggga gtttgtggag aactctgagt 1920 gcatacagtg ccacccagag tgcctgcctc aggccatgaa catcacctgc acaggacggg 1980 gaccagacaa ctgtatccag tgtgcccact acattgacgg cccccactgc gtcaagacct 2040 gcccggcagg agtcatggga gaaaacaaca ccctggtctg gaagtacgca gacgccggcc 2100 atgtgtgcca cctgtgccat ccaaactgca cctacggatg cactgggcca ggtcttgaag 2160 gctgtccaac gaatgggcct aagatcccgt ccatcgccac tgggatggtg ggggccctcc 2220 tcttgctgct ggtggtggcc ctggggatcg gcctcttcat gcgaaggcgc cacatcgttc 2280 ggaagcgcac gctgcggagg ctgctgcagg agagggagct tgtggagcct cttacaccca 2340 gtggagaagc tcccaaccaa gctctcttga ggatcttgaa ggaaactgaa ttcaaaaaga 2400 tcaaagtgct gggctccggt gcgttcggca cggtgtataa gggactctgg atcccagaag 2460 gtgagaaagt taaaattccc gtcgctatca aggaattaag agaagcaaca tctccgaaag 2520 ccaacaagga aatcctcgat gaagcctacg tgatggccag cgtggacaac ccccacgtgt 2580 gccgcctgct gggcatctgc ctcacctcca ccgtgcagct catcacgcag ctcatgccct 2640 tcggctgcct cctggactat gtccgggaac acaaagacaa tattggctcc cagtacctgc 2700 tcaactggtg tgtgcagatc gcaaagggca tgaactactt ggaggaccgt cgcttggtgc 2760 accgcgacct ggcagccagg aacgtactgg tgaaaacacc gcagcatgtc aagatcacag 2820 attttgggct ggccaaactg ctgggtgcgg aagagaaaga ataccatgca gaaggaggca 2880 aagtgcctat caagtggatg gcattggaat caattttaca cagaatctat acccaccaga 2940 gtgatgtctg gagctacggg gtgactgttt gggagttgat gacctttgga tccaagccat 3000 atgacggaat ccctgccagc gagatctcct ccatcctgga gaaaggagaa cgcctccctc 3060 agccacccat atgtaccatc gatgtctaca tgatcatggt caagtgctgg atgatagacg 3120 cagatagtcg cccaaagttc cgtgagttga tcatcgaatt ctccaaaatg gcccgagacc 3180 cccagcgcta ccttgtcatt cagggggatg aaagaatgca tttgccaagt cctacagact 3240 ccaacttcta ccgtgccctg atggatgaag aagacatgga cgacgtggtg gatgccgacg 3300 agtacctcat cccacagcag ggcttcttca gcagcccctc cacgtcacgg actcccctcc 3360 tgagctctct gagtgcaacc agcaacaatt ccaccgtggc ttgcattgat agaaatgggc 3420 tgcaaagctg tcccatcaag gaagacagct tcttgcagcg atacagctca gaccccacag 3480 gcgccttgac tgaggacagc atagacgaca ccttcctccc agtgcctgaa tacataaacc 3540 agtccgttcc caaaaggccc gctggctctg tgcagaatcc tgtctatcac aatcagcctc 3600 tgaaccccgc gcccagcaga gacccacact accaggaccc ccacagcact gcagtgggca 3660 accccgagta tctcaacact gtccagccca cctgtgtcaa cagcacattc gacagccctg 3720 cccactgggc ccagaaaggc agccaccaaa ttagcctgga caaccctgac taccagcagg 3780 acttctttcc caaggaagcc aagccaaatg gcatctttaa gggctccaca gctgaaaatg 3840 cagaatacct aagggtcgcg ccacaaagca gtgaatttat tggagcatga ccacggagga 3900 tagtatgagc cctaaaaatc cagactcttt cgatacccag gaccaagcca cagcaggtcc 3960 tccatcccaa cagccatgcc cgcattagct cttagaccca cagactggtt ttgcaacgtt 4020 tacaccgact agccaggaag tacttccacc tcgggcacat tttgggaagt tgcattcctt 4080 tgtcttcaaa ctgtgaagca tttacagaaa cgcatccagc aagaatattg tccctttgag 4140 cagaaattta tctttcaaag aggtatattt gaaaaaaaaa aaaagtatat gtgaggattt 4200 ttattgattg gggatcttgg agtttttcat tgtcgctatt gatttttact tcaatgggct 4260 cttccaacaa ggaagaagct tgctggtagc acttgctacc ctgagttcat ccaggcccaa 4320 ctgtgagcaa ggagcacaag ccacaagtct tccagaggat gcttgattcc agtggttctg 4380 cttcaaggct tccactgcaa aacactaaag atccaagaag gccttcatgg ccccagcagg 4440 ccggatcggt actgtatcaa gtcatggcag gtacagtagg ataagccact ctgtcccttc 4500 ctgggcaaag aagaaacgga ggggatggaa ttcttcctta gacttacttt tgtaaaaatg 4560 tccccacggt acttactccc cactgatgga ccagtggttt ccagtcatga gcgttagact 4620 gacttgtttg tcttccattc cattgttttg aaactcagta tgctgcccct gtcttgctgt 4680 catgaaatca gcaagagagg atgacacatc aaataataac tcggattcca gcccacattg 4740 gattcatcag catttggacc aatagcccac agctgagaat gtggaatacc taaggatagc 4800 accgcttttg ttctcgcaaa aacgtatctc ctaatttgag gctcagatga aatgcatcag 4860 gtcctttggg gcatagatca gaagactaca aaaatgaagc tgctctgaaa tctcctttag 4920 ccatcacccc aaccccccaa aattagtttg tgttacttat ggaagatagt tttctccttt 4980 tacttcactt caaaagcttt ttactcaaag agtatatgtt ccctccaggt cagctgcccc 5040 caaaccccct ccttacgctt tgtcacacaa aaagtgtctc tgccttgagt catctattca 5100 agcacttaca gctctggcca caacagggca ttttacaggt gcgaatgaca gtagcattat 5160 gagtagtgtg gaattcaggt agtaaatatg aaactagggt ttgaaattga taatgctttc 5220 acaacatttg cagatgtttt agaaggaaaa aagttccttc ctaaaataat ttctctacaa 5280 ttggaagatt ggaagattca gctagttagg agcccacctt ttttcctaat ctgtgtgtgc 5340 cctgtaacct gactggttaa cagcagtcct ttgtaaacag tgttttaaac tctcctagtc 5400 aatatccacc ccatccaatt tatcaaggaa gaaatggttc agaaaatatt ttcagcctac 5460 agttatgttc agtcacacac acatacaaaa tgttcctttt gcttttaaag taatttttga 5520 ctcccagatc agtcagagcc cctacagcat tgttaagaaa gtatttgatt tttgtctcaa 5580 tgaaaataaa actatattca tttccactct attatgctct caaatacccc taagcatcta 5640 tactagcctg gtatgggtat gaaagataca aagataaata aaacatagtc cctgattcta 5700 agaaattcac aatttagcaa aggaaatgga ctcatagatg ctaaccttaa aacaacgtga 5760 caaatgccag acaggaccca tcagccaggc actgtgagag cacagagcag ggaggttggg 5820 tcctgcctga ggagacctgg aagggaggcc tcacaggagg atgaccaggt ctcagtcagc 5880 ggggaggtgg aaagtgcagg tgcatcaggg gcaccctgac cgaggaaaca gctgccagag 5940 gcctccactg ctaaagtcca cataaggctg aggtcagtca ccctaaacaa cctgctccct 6000 ctaagccagg ggatgagctt ggagcatccc acaagttccc taaaagttgc agcccccagg 6060 gggattttga gctatcatct ctgcacatgc ttagtgagaa gactacacaa catttctaag 6120 aatctgagat tttatattgt cagttaacca ctttcattat tcattcacct caggacatgc 6180 agaaatattt cagtcagaac tgggaaacag aaggacctac attctgctgt cacttatgtg 6240 tcaagaagca gatgatcgat gaggcaggtc agttgtaagt gagtcacatt gtagcattaa 6300 attctagtat ttttgtagtt tgaaacagta acttaataaa agagcaaaag ctaaaaaaaa 6360 aaaaaaaaa 6369 <210> 204 <211> 3137 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3137) <223> EGR1 mRNA <400> 204 gagagatccc agcgcgcaga acttggggag ccgccgccgc catccgccgc cgcagccagc 60 ttccgccgcc gcaggaccgg cccctgcccc agcctccgca gccgcggcgc gtccacgccc 120 gcccgcgccc agggcgagtc ggggtcgccg cctgcacgct tctcagtgtt ccccgcgccc 180 cgcatgtaac ccggccaggc ccccgcaact gtgtcccctg cagctccagc cccgggctgc 240 acccccccgc cccgacacca gctctccagc ctgctcgtcc aggatggccg cggccaaggc 300 cgagatgcag ctgatgtccc cgctgcagat ctctgacccg ttcggatcct ttcctcactc 360 gcccaccatg gacaactacc ctaagctgga ggagatgatg ctgctgagca acggggctcc 420 ccagttcctc ggcgccgccg gggccccaga gggcagcggc agcaacagca gcagcagcag 480 cagcgggggc ggtggaggcg gcgggggcgg cagcaacagc agcagcagca gcagcacctt 540 caaccctcag gcggacacgg gcgagcagcc ctacgagcac ctgaccgcag agtcttttcc 600 tgacatctct ctgaacaacg agaaggtgct ggtggagacc agttacccca gccaaaccac 660 tcgactgccc cccatcacct atactggccg cttttccctg gagcctgcac ccaacagtgg 720 caacaccttg tggcccgagc ccctcttcag cttggtcagt ggcctagtga gcatgaccaa 780 cccaccggcc tcctcgtcct cagcaccatc tccagcggcc tcctccgcct ccgcctccca 840 gagcccaccc ctgagctgcg cagtgccatc caacgacagc agtcccattt actcagcggc 900 acccaccttc cccacgccga acactgacat tttccctgag ccacaaagcc aggccttccc 960 gggctcggca gggacagcgc tccagtaccc gcctcctgcc taccctgccg ccaagggtgg 1020 cttccaggtt cccatgatcc ccgactacct gtttccacag cagcaggggg atctgggcct 1080 gggcacccca gaccagaagc ccttccaggg cctggagagc cgcacccagc agccttcgct 1140 aacccctctg tctactatta aggcctttgc cactcagtcg ggctcccagg acctgaaggc 1200 cctcaatacc agctaccagt cccagctcat caaacccagc cgcatgcgca agtaccccaa 1260 ccggcccagc aagacgcccc cccacgaacg cccttacgct tgcccagtgg agtcctgtga 1320 tcgccgcttc tcccgctccg acgagctcac ccgccacatc cgcatccaca caggccagaa 1380 gcccttccag tgccgcatct gcatgcgcaa cttcagccgc agcgaccacc tcaccaccca 1440 catccgcacc cacacaggcg aaaagccctt cgcctgcgac atctgtggaa gaaagtttgc 1500 caggagcgat gaacgcaaga ggcataccaa gatccacttg cggcagaagg acaagaaagc 1560 agacaaaagt gttgtggcct cttcggccac ctcctctctc tcttcctacc cgtccccggt 1620 tgctacctct tacccgtccc cggttactac ctcttatcca tccccggcca ccacctcata 1680 cccatcccct gtgcccacct ccttctcctc tcccggctcc tcgacctacc catcccctgt 1740 gcacagtggc ttcccctccc cgtcggtggc caccacgtac tcctctgttc cccctgcttt 1800 cccggcccag gtcagcagct tcccttcctc agctgtcacc aactccttca gcgcctccac 1860 agggctttcg gacatgacag caaccttttc tcccaggaca attgaaattt gctaaaggga 1920 aaggggaaag aaagggaaaa gggagaaaaa gaaacacaag agacttaaag gacaggagga 1980 ggagatggcc ataggagagg agggttcctc ttaggtcaga tggaggttct cagagccaag 2040 tcctccctct ctactggagt ggaaggtcta ttggccaaca atcctttctg cccacttccc 2100 cttccccaat tactattccc tttgacttca gctgcctgaa acagccatgt ccaagttctt 2160 cacctctatc caaagaactt gatttgcatg gattttggat aaatcatttc agtatcatct 2220 ccatcatatg cctgacccct tgctcccttc aatgctagaa aatcgagttg gcaaaatggg 2280 gtttgggccc ctcagagccc tgccctgcac ccttgtacag tgtctgtgcc atggatttcg 2340 tttttcttgg ggtactcttg atgtgaagat aatttgcata ttctattgta ttatttggag 2400 ttaggtcctc acttggggga aaaaaaaaaa agaaaagcca agcaaaccaa tggtgatcct 2460 ctattttgtg atgatgctgt gacaataagt ttgaaccttt ttttttgaaa cagcagtccc 2520 agtattctca gagcatgtgt cagagtgttg ttccgttaac ctttttgtaa atactgcttg 2580 accgtactct cacatgtggc aaaatatggt ttggtttttc tttttttttt tttttgaaag 2640 tgttttttct tcgtcctttt ggtttaaaaa gtttcacgtc ttggtgcctt ttgtgtgatg 2700 cgccttgctg atggcttgac atgtgcaatt gtgagggaca tgctcacctc tagccttaag 2760 gggggcaggg agtgatgatt tgggggaggc tttgggagca aaataaggaa gagggctgag 2820 ctgagcttcg gttctccaga atgtaagaaa acaaaatcta aaacaaaatc tgaactctca 2880 aaagtctatt tttttaactg aaaatgtaaa tttataaata tattcaggag ttggaatgtt 2940 gtagttacct actgagtagg cggcgatttt tgtatgttat gaacatgcag ttcattattt 3000 tgtggttcta ttttactttg tacttgtgtt tgcttaaaca aagtgactgt ttggcttata 3060 aacacattga atgcgcttta ttgcccatgg gatatgtggt gtatatcctt ccaaaaaatt 3120 aaaacgaaaa taaagta 3137 <210> 205 <211> 5913 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(5913) <223> EMP1 mRNA <400> 205 acacacccca gtacaccagc agaggaaact tataacctcg ggaggcaggt ccttcccctc 60 agtgcggtca catacttcca gaagagcgga ccagggctgc tgccagcacc tgccactcag 120 agcgcctctg tcgctgggac ccttcagaac tctctttgct cacaagttac caaaaaaaaa 180 agagccaaca tgttggtatt gctggctggt atctttgtgg tccacatcgc tactgttatt 240 atgctatttg ttagcaccat tgccaatgtc tggttggttt ccaatacggt agatgcatca 300 gtaggtcttt ggaaaaactg taccaacatt agctgcagtg acagcctgtc atatgccagt 360 gaagatgccc tcaagacagt gcaggccttc atgattctct ctatcatctt ctgtgtcatt 420 gccctcctgg tcttcgtgtt ccagctcttc accatggaga agggaaaccg gttcttcctc 480 tcaggggcca ccacactggt gtgctggctg tgcattcttg tgggggtgtc catctacact 540 agtcattatg cgaatcgtga tggaacgcag tatcaccacg gctattccta catcctgggc 600 tggatctgct tctgcttcag cttcatcatc ggcgttctct atctggtcct gagaaagaaa 660 taaggccgga cgagttcatg gggatctggg gggtggggag gaggaagccg ttgaatctgg 720 gagggaagtg gaggttgctg tacaggaaaa accgagatag gggagggggg agggggaagc 780 aaagggggga ggtcaaatcc caaaccatta ctgaggggat tctctactgc caagcccctg 840 ccctggggag aaagtagttg gctagtactt tgatgctccc ttgatggggt ccagagagcc 900 tccctgcagc caccagactt ggcctccagc tgttcttagt gacacacact gtctggggcc 960 ccatcagctg ccacaacacc agccccactt ctgggtcatg cactgaggtc cacagaccta 1020 ctgcactgag ttaaaatagc ggtacaagtt ctggcaagag cagatactgt ctttgtgctg 1080 aatacgctaa gcctggaagc catcctgccc ttctgaccca aagcaaaaca tcacattcca 1140 gtctgaagtg cctactgggg ggctttggcc tgtgagccat tgtccctctt tggaacagat 1200 atttagctct gtggaattca gtgacaaaat gggaggagga aagagagttt gtaaggtcat 1260 gctggtgggt tagctaaacc aagaaggaga ccttttcaca atggaaaacc tgggggatgg 1320 tcagagccca gtcgagacct cacacacggc tgtccctcat ggagacctca tgccatggtc 1380 tttgctaggc ctcttgctga aagccaaggc agctcttctg gagtttctct aaagtcacta 1440 gtgaacaatt cggtggtaaa agtaccacac aaactatggg atccaagggg cagtcttgca 1500 acagtgccat gttagggtta tgtttttagg attcccctca atgcagtcag tgtttctttt 1560 aagtatacaa caggagagag atggacatgg ctcattgtag cacaatccta ttactcttcc 1620 tctaacattt ttgaggaagt tttgtctaat tatcaatatt gaggatcagg gctcctaggc 1680 tcagtggtag ctctggctta gacaccacct ggagtgatca cctcttgggg accctgccta 1740 tcccacttca caggtgaggc atggcaattc tggaagctga ttaaaacaca cataaaccaa 1800 aaccaaacaa caggcccttg ggtgaaaggt gctatataat tgtgaagtat taagcctacc 1860 gtatttcagc catgataaga acagagtgcc tgcattccca ggaaaatacg aaaatcccat 1920 gagataaata aaaatatagg tgatgggcag atcttttctt taaaataaaa aagcaaaaac 1980 tcttgtggta cctagtcaga tggtagacga gctgtctgct gccgcaggag cacctctata 2040 caggacttag aagtagtatg ttattcctgg ttaagcaggc attgctttgc cctggagcag 2100 ctattttaag ccatctcaga ttctgtctaa aggggttttt tgggaagacg ttttctttat 2160 cgccctgaga agatctaccc cagggagaat ctgagacatc ttgcctactt ttctttatta 2220 gctttctcct catccatttc ttttatacct ttcctttttg gggagttgtt atgccatgat 2280 ttttggtatt tatgtaaaag gattattact aattctattt ctctatgttt attctagtta 2340 aggaaatgtt gagggcaagc caccaaatta cctaggctga ggttagagag attggccagc 2400 aaaaactgtg ggaagatgaa ctttgtcatt atgatttcat tatcacatga ttatagaagg 2460 ctgtcttagt gcaaaaaaca tacttacatt tcagacatat ccaaagggaa tactcacatt 2520 ttgttaagaa gttgaactat gactggagta aaccatgtat tcccttatct tttacttttt 2580 ttctgtgaca tttatgtctc atgtaatttg cattactctg gtggattgtt ctagtactgt 2640 attgggcttc ttcgttaata gattatttca tatactataa ttgtaaatat tttgatacaa 2700 atgtttataa ctctagggat ataaaaacag attctgattc ccttcattgt gtgaatgttt 2760 ttttctaaaa aaaatgtgga gaaatatgga taattatgac atttatccct cattaagctg 2820 cctatcagtt tgatttggac aacttgacat ttatttgaga cattaagcta ctttctggta 2880 atatattagg catttctgca atagctcttt caggtaactg aatattatta agcatagttt 2940 tatcttgctt tgattaaacc tcttaggcaa aaaatggaac ttcataagct aatacattag 3000 aaaggggtta tgattataaa tcagaaatgc ttgtgacatt aagaaatgag gcacttgtga 3060 aatttctttg aaatagccag ctcctctaat gtgtcttcaa aatataaagt gattcacaaa 3120 ggcatgcatc acacctattt gtagcagccc attcattaca taaaccaggg catacctgtg 3180 tgggctctgt gagtgaaggg aggcttcact actttctgtg agcagtaagg actggtatct 3240 ttctgtgagc aataaggact ggataaagac tgcatatcct tgtgtcgtgt cagcaccaat 3300 acaataagga gggttttaat gtgaagcagg caatcttcca gccccttctg gtcttggatg 3360 aaatagttgc acagagtatt gcaccaaaaa tacacaatgg aggctgaaaa gttcaacata 3420 ttttaagtca attaatcaaa ttgcattgat tcttgatgct ttcttagagg cctacatgat 3480 ttcttagatt gctctgataa actatcataa ggggtccacc tcccctcatt tagctccccc 3540 agggatttct tttcccccat gtcatacacc cagtcctaaa tcaaccccca aggctatcct 3600 tccatccctt ctgcagaggg aacttttgtc agactctgca acaaactcct agctctatcc 3660 agagtgtcct ctgctgctaa gattggtatc tttctcctca aaagcctgga tggtgaatgg 3720 gggtgcatta gtcagaattc tccagagaaa cagaaaaaat aagattcgcg tgtgtgtgca 3780 aacatatata taaataaata aaaatatatt tattttaagg aattgactca catgattttg 3840 aaggcaggca agcccaaagt ctgcaagggg tgggccagca gagagctggt gctacagtgc 3900 gggtctgaaa gttgccagag tcccttttat agagaagctt aaaaaatatt tgttgaatta 3960 aatgtcttag gtagagacaa attgaattaa agtggttaag taaatactct taggtgaaat 4020 ttgtgcaaat tatgagtata aagagggtga gctacagaac tctccatgac cactcaagaa 4080 tgggacccaa aggcaaatga taacttattc attcatcaag ggataaactt gagttatcaa 4140 atggttaata gataaagatc ccactctgcc ttggatttag ccatcgcagt ccctgtgtaa 4200 aaccccaccg gctttcaggc atggaaaaaa atttcacaaa ggccttgaaa gaaggcatat 4260 gaagaccaaa aggatattga gcagggttcc atacttgaat aaaggaagaa actcccttca 4320 atgtttacta agaaatagtt agaatatagc atatcctgta tagatgaaat gtcctagcga 4380 aaatgtttaa atgtatttaa agaagagcta gattttgtgg ggggagagaa gggaatagga 4440 taggctggtg ggaggaagaa tgaaaagaag aaaacttgtt ggaaattttg gagtagattg 4500 tgaggagggg tgactcactt taaagatgta tcatttggag gtagacacga ttttcagagc 4560 acaaaacaga taaggaaaga tgtatgctga ttgtgtggag cccaagggaa ggcggggttt 4620 tggagtctta cgtggctttg tttctgaaag ggagacatgt gaagcctact cctgaggcgg 4680 gaggctgggg acatgaccat caagacctat aattgataaa caactagggg ctgggtgctg 4740 cacctacatg ctggggaaat agaaaatgaa gcagacatgt gtcccatctt cttccagctt 4800 tcagtctagc ttggaaataa atctcatacc tagagaaaat ggaggatctg tgggatgtag 4860 atgaggtggg agcatgaatg cctagggagg gaagaagaaa gattttcagt tcttcagctt 4920 ttcctcatga ccctatctca tgccatgagc aattgtctgg catctcctgt gggttggacc 4980 actgctgcat ttcttacttg ccaacatcac tttgtcccaa atgccattcc tttgttccag 5040 ggcctccttg tcttccatct ggggaactgg aggtgagaag cattataata gcctctctgc 5100 ctttatctac aatctctcca acctgtgctt tatgctgatg tcaggatggg cgttgatgga 5160 tgcttctatc actgtcgggg cagggagggc cagaacacta gcataagatg tcaatatgtc 5220 tatccatatg tcaggtccat actcaactca agcttctggt taactgctga tctattggca 5280 actccagttc ccaataagtt cctcatctcc ttctgagacc acctcagtgt ggacttaatc 5340 gtccacatca ctgtcagcat tttggttaaa accattcaac aagtctccag gaagctccaa 5400 actttccttc atcttcctgt cttcttctga gccctccaaa ctcttccaac ctctacccgt 5460 tacccagttc caaaggtgct tccacacttt caagtatctt tatagcaatg ccccactcct 5520 ggtaccaaat tcctgtatta gtctgttttc acactgctat gaagacatac ttgagactcg 5580 gtaatttata tagaaaagag gtttaattga caaaaaagct aacaaagtga gccctgattc 5640 aaaaatgact gtctacactt ggcacatgag ggactttatg atattaagag attaattaaa 5700 caacagtgga tggggaggaa gaacagactt ttgagctctt cccaatatag gaatgtgtta 5760 gttctaaaaa ttttcttaag ttgtttgctt ggaactcaga gtatattttt ccatacgaaa 5820 aattcagaac tattttattt atgatatggg ctaaaaagac ttctgtaatc tagcttggaa 5880 acttaataat cattaaactt attttcaatg aga 5913 <210> 206 <211> 3176 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3176) <223> ENO1 mRNA <400> 206 agtatctgtg ggtacccgga gcacggagat ctcgccggct ttacgttcac ctcggtgtct 60 gcagcaccct ccgcttcctc tcctaggcga cgagacccag tggctagaag ttcaccatgt 120 ctattctcaa gatccatgcc agggagatct ttgactctcg cgggaatccc actgttgagg 180 ttgatctctt cacctcaaaa ggtctcttca gagctgctgt gcccagtggt gcttcaactg 240 gtatctatga ggccctagag ctccgggaca atgataagac tcgctatatg gggaagggta 300 agccttagaa cccacagccc atggcctccc tgcttccagc cccattcctg gccttgccca 360 gtcctgtcct ctctgggtgg cacttgcact tgcaggttta tggcaggtaa acctgctgtg 420 acccatgatg ttgatggaag cagtgcacca ccttgtggac aggaaagttg gtgtgtggat 480 tccggggttc ccgagcctgc atgctctggg tcgagagttc caatgcttgc ttctattgca 540 gtttgttccc aatctgcgaa atactccttc acggttagga caggaaccca agcatgagaa 600 cagggcctgt taactaaaga aaagtttccc catctcccag gagggttctg tgggccctcc 660 agagatcatc agcctcttca cgggctagaa aggatccagg gaaggtctaa ccaatgacct 720 gccctgaatg gtgagctgca ggtgtgtcat ttagtgtgat tttcctgttg actgactcat 780 aggagccctg ctctgtggca gagctagcct ctggctgtat tcaaattgac ttagtgtgtg 840 tgcaacattg acctttctag agatagaaca tgtggccaaa ttacagaaaa gcacataggg 900 ctagatcacg cattctcagt ggggcacccg gaaaactcca aaaaggctgc agggagggga 960 caatgatgaa atcaggttgt gaaacactgg gctggtgtcg cagtggtggt gctgggtgtt 1020 cagtcccgct ttaatgctgt aagaagcact ctacacacac gaacatgtta ccatttgacc 1080 gttgtttaat ggcgtacgtg gggacttagc cggagcagga tgatgctgtg ccttgatggt 1140 aatgagtgct cagtaagtaa gcatttgtgg aagattgaac gcatggcccc tgaaatgctc 1200 tcctctgctt tcctgccccc tcactgtctc tcactcgcag tccttaatca ccggttctct 1260 tctgagtctc tctcattttt ccttcttcat cctctgctgg gcaggcgtct ccagacccat 1320 taagtatatt aatgagttcc tggcaccagc cctgtgcact caggtaactg attgaacagc 1380 ctttagtctg cagttggcgt ttccagtgca tggtcttgca aactaacctc cagtcagatc 1440 gttctgagcc agctgctgtt ttgtgtggct ctaaccctct ggggtcctag gtaggagcac 1500 tcagactggg ccggaaagtc ctccgattct ggggggaaag gggagagggg gaagaggtcc 1560 cacagaaggt cccttggtgg gcttccgcgt cggcctcaac agtggttctc tctaacaatg 1620 ctgctcaagc ctgttttaaa gttaatgtca gtaatttgat ttgattgttc cttccaggtg 1680 tctcaaaggc tgttgagcac atcaataaaa ctattgcgcc tgccctggtt agcaagaaac 1740 tgaacgtcac agaacaagag aagattgaca aactgatgat cgagatggat ggaacagaaa 1800 ataaatctaa gtttggtgcg aacgccattc tgggggtgtc ccttgccgtc tgcaaagctg 1860 gtgccgttga gaagggggtc cccctgtacc gccacatcgc tgacttggct ggcaactctg 1920 aagtcatcct gccagtcccg gcgttcaatg tcatcaatgg cggttctcat gctggcaaca 1980 agctggccat gcaggagttc atgatcctcc cagtcggtgc agcaaacttc agggaagcca 2040 tgcgcattgg agcagaggtt taccacaacc tgaagaatgt catcaaggag aaatatggga 2100 aagatgccac caatgtgggg gatgaaggcg ggtttgctcc caacatcctg gagaataaag 2160 aaggcctgga gctgctgaag actgctattg ggaaagctgg ctacactgat aaggtggtca 2220 tcggcatgga cgtagcggcc tccgagttct tcaggtctgg gaagtatgac ctggacttca 2280 agtctcccga tgaccccagc aggtacatct cgcctgacca gctggctgac ctgtacaagt 2340 ccttcatcaa ggactaccca gtggtgtcta tcgaagatcc ctttgaccag gatgactggg 2400 gagcttggca gaagttcaca gccagtgcag gaatccaggt agtgggggat gatctcacag 2460 tgaccaaccc aaagaggatc gccaaggccg tgaacgagaa gtcctgcaac tgcctcctgc 2520 tcaaagtcaa ccagattggc tccgtgaccg agtctcttca ggcgtgcaag ctggcccagg 2580 ccaatggttg gggcgtcatg gtgtctcatc gttcggggga gactgaagat accttcatcg 2640 ctgacctggt tgtggggctg tgcactgggc agatcaagac tggtgcccct tgccgatctg 2700 agcgcttggc caagtacaac cagctcctca gaattgaaga ggagctgggc agcaaggcta 2760 agtttgccgg caggaacttc agaaacccct tggccaagta agctgtgggc aggcaagccc 2820 ttcggtcacc tgttggctac acagacccct cccctcgtgt cagctcaggc agctcgaggc 2880 ccccgaccaa cacttgcagg ggtccctgct agttagcgcc ccaccgccgt ggagttcgta 2940 ccgcttcctt agaacttcta cagaagccaa gctccctgga gccctgttgg cagctctagc 3000 tttgcagtcg tgtaattggc ccaagtcatt gtttttctcg cctcactttc caccaagtgt 3060 ctagagtcat gtgagcctcg tgtcatctcc ggggtggcca caggctagat ccccggtggt 3120 tttgtgctca aaataaaaag cctcagtgac ccatgagaaa aaaaaaaaaa aaaaaa 3176 <210> 207 <211> 3097 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3097) <223> ERRFI1 mRNA <400> 207 gacggcggtc cggtgcgagg cagagtgcta gcgggagcgc gagccagcaa gaggcgcctg 60 cgcgatgtcc gggcccctga gcccgcggcg ctgagccagc cgggacggac atgcgcggga 120 gggcgccgcg gggcagccgc cgctcctccg ggggaatgaa agctactggt tgattttaaa 180 gtgcctgggc ctcacaggtt tggagatgtc ccagaataag gcacaatgtc aatagcagga 240 gttgctgctc aggagatcag agtcccatta aaaactggat ttctacataa tggccgagcc 300 atggggaata tgaggaagac ctactggagc agtcgcagtg agtttaaaaa caacttttta 360 aatattgacc cgataaccat ggcctacagt ctgaactctt ctgctcagga gcgcctaata 420 ccacttgggc atgcttccaa atctgctccg atgaatggcc actgctttgc agaaaatggt 480 ccatctcaaa agtccagctt gccccctctt cttattcccc caagtgaaaa cttgggacca 540 catgaagagg atcaagttgt atgtggtttt aagaaactca cagtgaatgg ggtttgtgct 600 tccacccctc cactgacacc cataaaaaac tccccttccc ttttcccctg tgcccctctt 660 tgtgaacggg gttctaggcc tcttccaccg ttgccaatct ctgaagccct ctctctggat 720 gacacagact gtgaggtgga attcctaact agctcagata cagacttcct tttagaagac 780 tctacacttt ctgatttcaa atatgatgtt cctggcaggc gaagcttccg tgggtgtgga 840 caaatcaact atgcatattt tgatacccca gctgtttctg cagcagatct cagctatgtg 900 tctgaccaaa atggaggtgt cccagatcca aatcctcctc cacctcagac ccaccgaaga 960 ttaagaaggt ctcattcggg accagctggc tcctttaaca agccagccat aaggatatcc 1020 aactgttgta tacacagagc ttctcctaac tccgatgaag acaaacctga ggttcccccc 1080 agagttccca tacctcctag accagtaaag ccagattata gaagatggtc agcagaagtt 1140 acttcgagca cctatagtga tgaagacagg cctcccaaag taccgccaag agaacctttg 1200 tcaccgagta actcgcgcac accgagtccc aaaagccttc cgtcttacct caatggggtc 1260 atgcccccga cacagagctt tgcccctgat cccaagtatg tcagcagcaa agcactgcaa 1320 agacagaaca gcgaaggatc tgccagtaag gttccttgca ttctgcccat tattgaaaat 1380 gggaagaagg ttagttcaac acattattac ctactacctg aacgaccacc atacctggac 1440 aaatatgaaa aattttttag ggaagcagaa gaaacaaatg gaggcgccca aatccagcca 1500 ttacctgctg actgcggtat atcttcagcc acagaaaagc cagactcaaa aacaaaaatg 1560 gatctgggtg gccacgtgaa gcgtaaacat ttatcctatg tggtttctcc ttagaccttg 1620 gggtcatggt tcagcagagg ttacatagga gcaaatggtt ctcaattttc cagtttgatt 1680 gaagtgcaga gaaaaatccc ttagattgca aaataaaata gttgaactct ctgtcttcat 1740 gtggaaggtt tagagcagtt gtgagatgct gttatgctga gaaaccctga ctttgttagt 1800 gttggaaaaa agtcttacaa gtctataatt taaagatgtg atggtgggga ggggaggatg 1860 gggaagcttt ttatatatgc atacattaca tacctatata taaacttgtg gtataaccat 1920 agaccatagc tgcaggttaa ccaattagtt actatcgtag agtaatatat attcagaata 1980 ataaactcaa gctggagaaa tgagtcctga tagactgaaa attgagcaaa tggaagaaga 2040 tacagtattg tttagatcag aatcattaaa aaatattttt gtttagtaag tttgaagatt 2100 tctggctttt aggccttttc tattttgttc catttatttt tgcaggcaat cttttccatg 2160 gagggcaggg tatccattct ttaccatggg tgtacctgct taggttaaaa atcataccaa 2220 ggcctcatac ttccaggttt catgttgcgt cttgttgagg gagggagagc aggttacttg 2280 gcaaccatat tgtcacctgt acctgtcaca catcttgaaa aataaaacga taatagaact 2340 agtgactaat tttcccttac agttcctgct tggtcccacc cactgaagta gctcatcgta 2400 gtgcgggccg tattagaggc agtggggtac gttagactca gatggaaaag tattctaggt 2460 gccagtgtta ggatgtcagt tttacaaaat aatgaagcaa ttagctatgt gattgagagt 2520 tattgtttgg ggatgtgtgt tgtggttttg cttttttttt ttagactgta ttaataaaca 2580 tacaacacaa gctggccttg tgttgctggt tcctattcag tatttcctgg ggattgtttg 2640 ctttttaagt aaaacacttc tgacccatag ctcagtatgt ctgaattcca gaggtcacat 2700 cagcatcttt ctgctttgaa aactctcaca gctgtggctg cttcacttag atgcagtgag 2760 acacatagtt ggtgttccga ttttcacatc cttccatgta tttatcttga agagataagc 2820 acagaagaga aggtgctcac taacagaggt acattactgc aatgttctct taacagttaa 2880 acaagctgtt tacagtttaa actgctgaat attatttgag ctatttaaag cttattatat 2940 tttagtatga actaaatgaa ggttaaaaca tgcttaagaa aaatgcactg atttctgcat 3000 tatgtgtaca gtattggaca aaggatttta ttcattttgt tgcattattt tgaatattgt 3060 cttttcattt taataaagtt ataatactta tttatga 3097 <210> 208 <211> 2089 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2089) <223> ESM1 mRNA <400> 208 agtttggacg gctgcttccc accagcaaag accacgactg gagagccgag ccggaggcag 60 ctgggaaaca tgaagagcgt cttgctgctg accacgctcc tcgtgcctgc acacctggtg 120 gccgcctgga gcaataatta tgcggtggac tgccctcaac actgtgacag cagtgagtgc 180 aaaagcagcc cgcgctgcaa gaggacagtg ctcgacgact gtggctgctg ccgagtgtgc 240 gctgcagggc ggggagaaac ttgctaccgc acagtctcag gcatggatgg catgaagtgt 300 ggcccggggc tgaggtgtca gccttctaat ggggaggatc cttttggtga agagtttggt 360 atctgcaaag actgtcccta cggcaccttc gggatggatt gcagagagac ctgcaactgc 420 cagtcaggca tctgtgacag ggggacggga aaatgcctga aattcccctt cttccaatat 480 tcagtaacca agtcttccaa cagatttgtt tctctcacgg agcatgacat ggcatctgga 540 gatggcaata ttgtgagaga agaagttgtg aaagagaatg ctgccgggtc tcccgtaatg 600 aggaaatggt taaatccacg ctgatcccgg ctgtgatttc tgagagaagg ctctattttc 660 gtgattgttc aacacacagc caacatttta ggaactttct agattatagc ataaggacat 720 gtaatttttg aagaccaaat gtgatgcatg gtggatccag aaaacaaaaa gtaggatact 780 tacaatccat aacatccata tgactgaaca cttgtatgtg tttgttaaat attcgaatgc 840 atgtagattt gttaaatgtg tgtgtatagt aacactgaag aactaaaaat gcaatttagg 900 taatcttacg tggagacagg tcaaccaaag agggagctag gcaaagctga agaccgcagt 960 gagtcaaatt agttctttga ctttgatgta cattaatgtt gggatatgga atgaagactt 1020 aagagcagga gaagatgggg agggggtggg agtgggaaat aaaatattta gcccttcctt 1080 ggtaggtagc ttctctagaa tttaattgtg cttttttttt tttttttggc tttgggaaaa 1140 gtcaaaataa aacaaccaga aaacccctga aggaagtaag atgtttgaag cttatggaaa 1200 tttgagtaac aaacagcttt gaactgagag caatttcaaa aggctgctga tgtagttccc 1260 gggttacctg tatctgaagg acggttctgg ggcataggaa acacatacac ttccataaat 1320 agctttaacg tatgccacct cagagataaa tctaagaagt attttaccca ctggtggttt 1380 gtgtgtgtat gaaggtaaat atttatatat ttttataaat aaatgtgtta gtgcaagtca 1440 tcttccctac ccatatttat catcctcttg aggaaagaaa tctagtatta tttgttgaaa 1500 atggttagaa taaaactatg actctataag gttttcaaac atctgaggca tgataaattt 1560 attatccata attatagtaa taataacctt aataagcata agaaaaacag agtcactctg 1620 gatttcaaaa atgtcaaaaa atgagcaaca gagggtcctt atttaaacat aagtgctgtg 1680 acttaggtga attttcaatt taaggtagaa aataagtttt taggaggttt gtaaaagaag 1740 aatcaatttt cagcagaaaa catgtcaact ttaaaatata gtttattttc atattttttt 1800 cttttaaact tggttgataa gtggaattag gagtatattt gaaagaatct tagcacaaac 1860 aggactgttg tactagatgt tcttaggaaa tatctcagaa gtattttatt tgaagtgaag 1920 aacttattta agaattattt cagtatttac ctgtatttta ttcttgaagt tggccaacag 1980 agttgtgaat gtgtgtggga aggcctttga atgtaaagct gcataagctg ttaggttttg 2040 ttttaaaagg acatgtttat tattgttcaa taaaaaagaa caagataca 2089 <210> 209 <211> 2248 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2248) <223> FGA mRNA <400> 209 aggatgggaa ctaggagtgg cagcaatcct ttctttcagc tggagtgctc ctcaggagcc 60 agccccaccc ttagaaaaga tgttttccat gaggatcgtc tgcctggtcc taagtgtggt 120 gggcacagca tggactgcag atagtggtga aggtgacttt ctagctgaag gaggaggcgt 180 gcgtggccca agggttgtgg aaagacatca atctgcctgc aaagattcag actggccctt 240 ctgctctgat gaagactgga actacaaatg cccttctggc tgcaggatga aagggttgat 300 tgatgaagtc aatcaagatt ttacaaacag aataaataag ctcaaaaatt cactatttga 360 atatcagaag aacaataagg attctcattc gttgaccact aatataatgg aaattttgag 420 aggcgatttt tcctcagcca ataaccgtga taatacctac aaccgagtgt cagaggatct 480 gagaagcaga attgaagtcc tgaagcgcaa agtcatagaa aaagtacagc atatccagct 540 tctgcagaaa aatgttagag ctcagttggt tgatatgaaa cgactggagg tggacattga 600 tattaagatc cgatcttgtc gagggtcatg cagtagggct ttagctcgtg aagtagatct 660 gaaggactat gaagatcagc agaagcaact tgaacaggtc attgccaaag acttacttcc 720 ctctagagat aggcaacact taccactgat aaaaatgaaa ccagttccag acttggttcc 780 cggaaatttt aagagccagc ttcagaaggt acccccagag tggaaggcat taacagacat 840 gccgcagatg agaatggagt tagagagacc tggtggaaat gagattactc gaggaggctc 900 cacctcttat ggaaccggat cagagacgga aagccccagg aaccctagca gtgctggaag 960 ctggaactct gggagctctg gacctggaag tactggaaac cgaaaccctg ggagctctgg 1020 gactggaggg actgcaacct ggaaacctgg gagctctgga cctggaagta ctggaagctg 1080 gaactctggg agctctggaa ctggaagtac tggaaaccaa aaccctggga gccctagacc 1140 tggtagtacc ggaacctgga atcctggcag ctctgaacgc ggaagtgctg ggcactggac 1200 ctctgagagc tctgtatctg gtagtactgg acaatggcac tctgaatctg gaagttttag 1260 gccagatagc ccaggctctg ggaacgcgag gcctaacaac ccagactggg gcacatttga 1320 agaggtgtca ggaaatgtaa gtccagggac aaggagagag taccacacag aaaaactggt 1380 cacttctaaa ggagataaag agctcaggac tggtaaagag aaggtcacct ctggtagcac 1440 aaccaccacg cgtcgttcat gctctaaaac cgttactaag actgttattg gtcctgatgg 1500 tcacaaagaa gttaccaaag aagtggtgac ctccgaagat ggttctgact gtcccgaggc 1560 aatggattta ggcacattgt ctggcatagg tactctggat gggttccgcc ataggcaccc 1620 tgatgaagct gccttcttcg acactgcctc aactggaaaa acattcccag gtttcttctc 1680 acctatgtta ggagagtttg tcagtgagac tgagtctagg ggctcagaat ctggcatctt 1740 cacaaataca aaggaatcca gttctcatca ccctgggata gctgaattcc cttcccgtgg 1800 taaatcttca agttacagca aacaatttac tagtagcacg agttacaaca gaggagactc 1860 cacatttgaa agcaagagct ataaaatggc agatgaggcc ggaagtgaag ccgatcatga 1920 aggaacacat agcaccaaga gaggccatgc taaatctcgc cctgtcagag gtatccacac 1980 ttctcctttg gggaagcctt ccctgtcccc ctagactaag ttaaatattt ctgcacagtg 2040 ttcccatggc cccttgcatt tccttcttaa ctctctgtta cacgtcattg aaactacact 2100 tttttggtct gtttttgtgc tagactgtaa gttccttggg ggcagggcct ttgtctgtct 2160 catctctgta ttcccaaatg cctaacagta cagagccatg actcaataaa tacatgttaa 2220 atggatgaat gaattcctct gaaactct 2248 <210> 210 <211> 6781 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6781) <223> FGF2 mRNA <400> 210 cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc 60 gcgggaggct ggtgggtgtg gggggtggag atgtagaaga tgtgacgccg cggcccggcg 120 ggtgccagat tagcggacgc ggtgcccgcg gttgcaacgg gatcccgggc gctgcagctt 180 gggaggcggc tctccccagg cggcgtccgc ggagacaccc atccgtgaac cccaggtccc 240 gggccgccgg ctcgccgcgc accaggggcc ggcggacaga agagcggccg agcggctcga 300 ggctggggga ccgcgggcgc ggccgcgcgc tgccgggcgg gaggctgggg ggccggggcc 360 ggggccgtgc cccggagcgg gtcggaggcc ggggccgggg ccgggggacg gcggctcccc 420 gcgcggctcc agcggctcgg ggatcccggc cgggccccgc agggaccatg gcagccggga 480 gcatcaccac gctgcccgcc ttgcccgagg atggcggcag cggcgccttc ccgcccggcc 540 acttcaagga ccccaagcgg ctgtactgca aaaacggggg cttcttcctg cgcatccacc 600 ccgacggccg agttgacggg gtccgggaga agagcgaccc tcacatcaag ctacaacttc 660 aagcagaaga gagaggagtt gtgtctatca aaggagtgtg tgctaaccgt tacctggcta 720 tgaaggaaga tggaagatta ctggcttcta aatgtgttac ggatgagtgt ttcttttttg 780 aacgattgga atctaataac tacaatactt accggtcaag gaaatacacc agttggtatg 840 tggcactgaa acgaactggg cagtataaac ttggatccaa aacaggacct gggcagaaag 900 ctatactttt tcttccaatg tctgctaaga gctgatttta atggccacat ctaatctcat 960 ttcacatgaa agaagaagta tattttagaa atttgttaat gagagtaaaa gaaaataaat 1020 gtgtatagct cagtttggat aattggtcaa acaatttttt atccagtagt aaaatatgta 1080 accattgtcc cagtaaagaa aaataacaaa agttgtaaaa tgtatattct cccttttata 1140 ttgcatctgc tgttacccag tgaagcttac ctagagcaat gatctttttc acgcatttgc 1200 tttattcgaa aagaggcttt taaaatgtgc atgtttagaa acaaaatttc ttcatggaaa 1260 tcatatacat tagaaaatca cagtcagatg tttaatcaat ccaaaatgtc cactatttct 1320 tatgtcattc gttagtctac atgtttctaa acatataaat gtgaatttaa tcaattcctt 1380 tcatagtttt ataattctct ggcagttcct tatgatagag tttataaaac agtcctgtgt 1440 aaactgctgg aagttcttcc acagtcaggt caattttgtc aaacccttct ctgtacccat 1500 acagcagcag cctagcaact ctgctggtga tgggagttgt attttcagtc ttcgccaggt 1560 cattgagatc catccactca catcttaagc attcttcctg gcaaaaattt atggtgaatg 1620 aatatggctt taggcggcag atgatataca tatctgactt cccaaaagct ccaggatttg 1680 tgtgctgttg ccgaatactc aggacggacc tgaattctga ttttatacca gtctcttcaa 1740 aaacttctcg aaccgctgtg tctcctacgt aaaaaaagag atgtacaaat caataataat 1800 tacactttta gaaactgtat catcaaagat tttcagttaa agtagcatta tgtaaaggct 1860 caaaacatta ccctaacaaa gtaaagtttt caatacaaat tctttgcctt gtggatatca 1920 agaaatccca aaatattttc ttaccactgt aaattcaaga agcttttgaa atgctgaata 1980 tttctttggc tgctacttgg aggcttatct acctgtacat ttttggggtc agctcttttt 2040 aacttcttgc tgctcttttt cccaaaaggt aaaaatatag attgaaaagt taaaacattt 2100 tgcatggctg cagttccttt gtttcttgag ataagattcc aaagaactta gattcatttc 2160 ttcaacaccg aaatgctgga ggtgtttgat cagttttcaa gaaacttgga atataaataa 2220 ttttataatt caacaaaggt tttcacattt tataaggttg atttttcaat taaatgcaaa 2280 tttgtgtggc aggattttta ttgccattaa catatttttg tggctgcttt ttctacacat 2340 ccagatggtc cctctaactg ggctttctct aattttgtga tgttctgtca ttgtctccca 2400 aagtatttag gagaagccct ttaaaaagct gccttcctct accactttgc tggaaagctt 2460 cacaattgtc acagacaaag atttttgttc caatactcgt tttgcctcta tttttcttgt 2520 ttgtcaaata gtaaatgata tttgcccttg cagtaattct actggtgaaa aacatgcaaa 2580 gaagaggaag tcacagaaac atgtctcaat tcccatgtgc tgtgactgta gactgtctta 2640 ccatagactg tcttacccat cccctggata tgctcttgtt ttttccctct aatagctatg 2700 gaaagatgca tagaaagagt ataatgtttt aaaacataag gcatttgtct gccatttttc 2760 aattacatgc tgacttccct tacaattgag atttgcccat aggttaaaca tggttagaaa 2820 caactgaaag cataaaagaa aaatctaggc cgggtgcagt ggctcatgcc tatattccct 2880 gcactttggg aggccaaagc aggaggatcg cttgagccca ggagttcaag accaacctgg 2940 tgaaaccccg tctctacaaa aaaacacaaa aaatagccag gcatggtggc gtgtacatgt 3000 ggtctcagat acttgggagg ctgaggtggg agggttgatc acttgaggct gagaggtcaa 3060 ggttgcagtg agccataatc gtgccactgc agtccagcct aggcaacaga gtgagacttt 3120 gtctcaaaaa aagagaaatt ttccttaata agaaaagtaa tttttactct gatgtgcaat 3180 acatttgtta ttaaatttat tatttaagat ggtagcacta gtcttaaatt gtataaaata 3240 tcccctaaca tgtttaaatg tccattttta ttcattatgc tttgaaaaat aattatgggg 3300 aaatacatgt ttgttattaa atttattatt aaagatagta gcactagtct taaatttgat 3360 ataacatctc ctaacttgtt taaatgtcca tttttattct ttatgtttga aaataaatta 3420 tggggatcct atttagctct tagtaccact aatcaaaagt tcggcatgta gctcatgatc 3480 tatgctgttt ctatgtcgtg gaagcactgg atgggggtag tgagcaaatc tgccctgctc 3540 agcagtcacc atagcagctg actgaaaatc agcactgcct gagtagtttt gatcagttta 3600 acttgaatca ctaactgact gaaaattgaa tgggcaaata agtgcttttg tctccagagt 3660 atgcgggaga cccttccacc tcaagatgga tatttcttcc ccaaggattt caagatgaat 3720 tgaaattttt aatcaagata gtgtgcttta ttctgttgta ttttttatta ttttaatata 3780 ctgtaagcca aactgaaata acatttgctg ttttataggt ttgaagaaca taggaaaaac 3840 taagaggttt tgtttttatt tttgctgatg aagagatatg tttaaatatg ttgtattgtt 3900 ttgtttagtt acaggacaat aatgaaatgg agtttatatt tgttatttct attttgttat 3960 atttaataat agaattagat tgaaataaaa tataatggga aataatctgc agaatgtggg 4020 ttttcctggt gtttccctct gactctagtg cactgatgat ctctgataag gctcagctgc 4080 tttatagttc tctggctaat gcagcagata ctcttcctgc cagtggtaat acgatttttt 4140 aagaaggcag tttgtcaatt ttaatcttgt ggataccttt atactcttag ggtattattt 4200 tatacaaaag ccttgaggat tgcattctat tttctatatg accctcttga tatttaaaaa 4260 acactatgga taacaattct tcatttacct agtattatga aagaatgaag gagttcaaac 4320 aaatgtgttt cccagttaac tagggtttac tgtttgagcc aatataaatg tttaactgtt 4380 tgtgatggca gtattcctaa agtacattgc atgttttcct aaatacagag tttaaataat 4440 ttcagtaatt cttagatgat tcagcttcat cattaagaat atcttttgtt ttatgttgag 4500 ttagaaatgc cttcatatag acatagtctt tcagacctct actgtcagtt ttcatttcta 4560 gctgctttca gggttttatg aattttcagg caaagcttta atttacacta agcttaggaa 4620 gtatggctaa tgccaacggc agtttttttc ttcttaattc cacatgactg aggcatatat 4680 gatctctggg taggtgagtt gttgtgacaa ccacaagcac tttttttttt tttaaagaaa 4740 aaaaggtagt gaatttttaa tcatctggac tttaagaagg attctggagt atacttaggc 4800 ctgaaattat atatatttgg cttggaaatg tgtttttctt caattacatc tacaagtaag 4860 tacagctgaa attcagagga cccataagag ttcacatgaa aaaaatcaat ttatttgaaa 4920 aggcaagatg caggagagag gaagccttgc aaacctgcag actgcttttt gcccaatata 4980 gattgggtaa ggctgcaaaa cataagctta attagctcac atgctctgct ctcacgtggc 5040 accagtggat agtgtgagag aattaggctg tagaacaaat ggccttctct ttcagcattc 5100 acaccactac aaaatcatct tttatatcaa cagaagaata agcataaact aagcaaaagg 5160 tcaataagta cctgaaacca agattggcta gagatatatc ttaatgcaat ccattttctg 5220 atggattgtt acgagttggc tatataatgt atgtatggta ttttgatttg tgtaaaagtt 5280 ttaaaaatca agctttaagt acatggacat ttttaaataa aatatttaaa gacaatttag 5340 aaaattgcct taatatcatt gttggctaaa tagaataggg gacatgcata ttaaggaaaa 5400 ggtcatggag aaataatatt ggtatcaaac aaatacattg atttgtcatg atacacattg 5460 aatttgatcc aatagtttaa ggaataggta ggaaaatttg gtttctattt ttcgatttcc 5520 tgtaaatcag tgacataaat aattcttagc ttattttata tttccttgtc ttaaatactg 5580 agctcagtaa gttgtgttag gggattattt ctcagttgag actttcttat atgacatttt 5640 actatgtttt gactacctga ctattaaaaa taaatagtag atacaatttt cataaagtga 5700 agaattatat aatcactgct ttataactga ctttattata tttatttcaa agttcattta 5760 aaggctacta ttcatcctct gtgatggaat ggtcaggaat ttgttttctc atagtttaat 5820 tccaacaaca atattagtcg tatccaaaat aacctttaat gctaaacttt actgatgtat 5880 atccaaagct tctcattttc agacagatta atccagaagc agtcataaac agaagaatag 5940 gtggtatgtt cctaatgata ttatttctac taatggaata aactgtaata ttagaaatta 6000 tgctgctaat tatatcagct ctgaggtaat ttctgaaatg ttcagactca gtcggaacaa 6060 attggaaaat ttaaattttt attcttagct ataaagcaag aaagtaaaca cattaatttc 6120 ctcaacattt ttaagccaat taaaaatata aaagatacac accaatatct tcttcaggct 6180 ctgacaggcc tcctggaaac ttccacatat ttttcaactg cagtataaag tcagaaaata 6240 aagttaacat aactttcact aacacacaca tatgtagatt tcacaaaatc cacctataat 6300 tggtcaaagt ggttgagaat atatttttta gtaattgcat gcaaaatttt tctagcttcc 6360 atcctttctc cctcgtttct tctttttttg ggggagctgg taactgatga aatcttttcc 6420 caccttttct cttcaggaaa tataagtggt tttgtttggt taacgtgata cattctgtat 6480 gaatgaaaca ttggagggaa acatctactg aatttctgta atttaaaata ttttgctgct 6540 agttaactat gaacagatag aagaatctta cagatgctgc tataaataag tagaaaatat 6600 aaatttcatc actaaaatat gctattttaa aatctatttc ctatattgta tttctaatca 6660 gatgtattac tcttattatt tctattgtat gtgttaatga ttttatgtaa aaatgtaatt 6720 gcttttcatg agtagtatga ataaaattga ttagtttgtg ttttcttgtc tcccaaaaaa 6780 a 6781 <210> 211 <211> 3936 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3936) <223> FGF7 mRNA <400> 211 agttttaatt gcttccaatg aggtcagcaa aggtatttat cgaaaagccc tgaataaaag 60 gctcacacac acacacaagc acacacgcgc tcacacacag agagaaaatc cttctgcctg 120 ttgatttatg gaaacaatta tgattctgct ggagaacttt tcagctgaga aatagtttgt 180 agctacagta gaaaggctca agttgcacca ggcagacaac agacatggaa ttcttatata 240 tccagctgtt agcaacaaaa caaaagtcaa atagcaaaca gcgtcacagc aactgaactt 300 actacgaact gtttttatga ggatttatca acagagttat ttaaggagga atcctgtgtt 360 gttatcagga actaaaagga taaggctaac aatttggaaa gagcaactac tctttcttaa 420 atcaatctac aattcacaga taggaagagg tcaatgacct aggagtaaca atcaactcaa 480 gattcatttt cattatgtta ttcatgaaca cccggagcac tacactataa tgcacaaatg 540 gatactgaca tggatcctgc caactttgct ctacagatca tgctttcaca ttatctgtct 600 agtgggtact atatctttag cttgcaatga catgactcca gagcaaatgg ctacaaatgt 660 gaactgttcc agccctgagc gacacacaag aagttatgat tacatggaag gaggggatat 720 aagagtgaga agactcttct gtcgaacaca gtggtacctg aggatcgata aaagaggcaa 780 agtaaaaggg acccaagaga tgaagaataa ttacaatatc atggaaatca ggacagtggc 840 agttggaatt gtggcaatca aaggggtgga aagtgaattc tatcttgcaa tgaacaagga 900 aggaaaactc tatgcaaaga aagaatgcaa tgaagattgt aacttcaaag aactaattct 960 ggaaaaccat tacaacacat atgcatcagc taaatggaca cacaacggag gggaaatgtt 1020 tgttgcctta aatcaaaagg ggattcctgt aagaggaaaa aaaacgaaga aagaacaaaa 1080 aacagcccac tttcttccta tggcaataac ttaattgcat atggtatata aagaaccagt 1140 tccagcaggg agatttcttt aagtggactg ttttctttct tctcaaaatt ttctttcctt 1200 ttatttttta gtaatcaaga aaggctggaa aactactgaa aaactgatca agctggactt 1260 gtgcatttat gtttgtttta agacactgca ttaaagaaag atttgaaaag tatacacaaa 1320 aatcagattt agtaactaaa ggttgtaaaa aattgtaaaa ctggttgtac aatcatgatg 1380 ttagtaacag taattttttt cttaaattaa tttaccctta agagtatgtt agatttgatt 1440 atctgataat gattatttaa atattcctat ctgcttataa aatggctgct ataataataa 1500 taatacagat gttgttatat aaggtatatc agacctacag gcttctggca ggatttgtca 1560 gataatcaag ccacactaac tatggaaaat gagcagcatt ttaaatgctt tctagtgaaa 1620 aattataatc tacttaaact ctaatcagaa aaaaaattct caaaaaaact attatgaaag 1680 tcaataaaat agataattta acaaaagtac aggattagaa catgcttata cctataaata 1740 agaacaaaat ttctaatgct gctcaagtgg aaagggtatt gctaaaagga tgtttccaaa 1800 aatcttgtat ataagatagc aacagtgatt gatgataata ctgtacttca tcttacttgc 1860 cacaaaataa cattttataa atcctcaaag taaaattgag aaatctttaa gtttttttca 1920 agtaacataa tctatctttg tataattcat atttgggaat atggctttta ataatgttct 1980 tcccacaaat aatcatgctt ttttcctatg gttacagcat taaactctat tttaagttgt 2040 ttttgaactt tattgttttg ttatttaagt ttatgttatt tataaaaaaa aaaccttaat 2100 aagctgtatc tgtttcatat gcttttaatt ttaaaggaat aacaaaactg tctggctcaa 2160 cggcaagttt ccctcccttt tctgactgac actaagtcta gcacacagca cttgggccag 2220 caaatcctgg aaggcagaca aaaataagag cctgaagcaa tgcttacaat agatgtctca 2280 cacagaacaa tacaaatatg taaaaaatct ttcaccacat attcttgcca attaattgga 2340 tcatataagt aaaatcatta caaatataag tatttacagg attttaaagt tagaatatat 2400 ttgaatgcat gggtagaaaa tatcatattt taaaactatg tatatttaaa tttagtaatt 2460 ttctaatctc tagaaatctc tgctgttcaa aaggtggcag cactgaaagt tgttttcctg 2520 ttagatggca agagcacaat gcccaaaata gaagatgcag ttaagaataa ggggccctga 2580 atgtcatgaa ggcttgaggt cagcctacag ataacaggat tattacaagg atgaatttcc 2640 acttcaaaag tctttcattg gcagatcttg gtagcacttt atatgttcac caatgggagg 2700 tcaatattta tctaatttaa aaggtatgct aaccactgtg gttttaattt caaaatattt 2760 gtcattcaag tccctttaca taaatagtat ttggtaatac atttatagat gagagttata 2820 tgaaaaggct aggtcaacaa aaacaataga ttcatttaat tttcctgtgg ttgacctata 2880 cgaccaggat gtagaaaact agaaagaact gcccttcctc agatatactc ttgggagaga 2940 gcatgaatgg tattctgaac tatcacctga ttcaaggact ttgctagcta ggttttgagg 3000 tcaggcttca gtaactgtag tcttgtgagc atattgaggg cagaggagga cttagttttt 3060 catatgtgtt tccttagtgc ctagcagact atctgttcat aatcagtttt cagtgtgaat 3120 tcactgaatg tttatagaca aaagaaaata cacactaaaa ctaatcttca ttttaaaagg 3180 gtaaaacatg actatacaga aatttaaata gaaatagtgt atatacatat aaaatacaag 3240 ctatgttagg accaaatgct ctttgtctat ggagttatac ttccatcaaa ttacatagca 3300 atgctgaatt aggcaaaacc aacatttagt ggtaaatcca ttcctggtag tataagtcac 3360 ctaaaaaaga cttctagaaa tatgtacttt aattatttgt ttttctccta tttttaaatt 3420 tattatgcaa attttagaaa ataaaatttg ctctagttac acacctttag aattctagaa 3480 tattaaaact gtaaggggcc tccatccctc ttactcattt gtagtctagg aaattgagat 3540 tttgatacac ctaaggtcac gcagctgggt agatatacag ctgtcacaag agtctagatc 3600 agttagcaca tgctttctac tcttcgatta ttagtattat tagctaatgg tctttggcat 3660 gtttttgttt tttatttctg ttgagatata gcctttacat ttgtacacaa atgtgactat 3720 gtcttggcaa tgcacttcat acacaatgac taatctatac tgtgatgatt tgactcaaaa 3780 ggagaaaaga aattatgtag ttttcaattc tgattcctat tcaccttttg tttatgaatg 3840 gaaagctttg tgcaaaatat acatataagc agagtaagcc ttttaaaaat gttctttgaa 3900 agataaaatt aaatacatga gtttctaaca attaga 3936 <210> 212 <211> 627 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(627) <223> FGF10 mRNA <400> 212 atgtggaaat ggatactgac acattgtgcc tcagcctttc cccacctgcc cggctgctgc 60 tgctgctgct ttttgttgct gttcttggtg tcttccgtcc ctgtcacctg ccaagccctt 120 ggtcaggaca tggtgtcacc agaggccacc aactcttctt cctcctcctt ctcctctcct 180 tccagcgcgg gaaggcatgt gcggagctac aatcaccttc aaggagatgt ccgctggaga 240 aagctattct ctttcaccaa gtactttctc aagattgaga agaacgggaa ggtcagcggg 300 accaagaagg agaactgccc gtacagcatc ctggagataa catcagtaga aatcggagtt 360 gttgccgtca aagccattaa cagcaactat tacttagcca tgaacaagaa ggggaaactc 420 tatggctcaa aagaatttaa caatgactgt aagctgaagg agaggataga ggaaaatgga 480 tacaatacct atgcatcatt taactggcag cataatggga ggcaaatgta tgtggcattg 540 aatggaaaag gagctccaag gagaggacag aaaacacgaa ggaaaaacac ctctgctcac 600 tttcttccaa tggtggtaca ctcatag 627 <210> 213 <211> 1759 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1759) <223> FOSL1 mRNA <400> 213 acgggccaag gcggcgcgtc tcgggggtgg agcctggagg tgaccgcgcc gctgcaacgc 60 ccccaccccc cgcggtcgca gtggttcagc ccgagaactt ttcattcata aaaagaaaag 120 actccgcacg gcgcgggtga gtcagaaccc agcagccgtg taccccgcag agccgccagc 180 cccgggcatg ttccgagact tcggggaacc cggcccgagc tccgggaacg gcggcgggta 240 cggcggcccc gcgcagcccc cggccgcagc gcaggcagcc cagcagaagt tccacctggt 300 gccaagcatc aacaccatga gtggcagtca ggagctgcag tggatggtac agcctcattt 360 cctggggccc agcagttacc ccaggcctct gacctaccct cagtacagcc ccccacaacc 420 ccggccagga gtcatccggg ccctggggcc gcctccaggg gtacgtcgaa ggccttgtga 480 acagatcagc ccggaggaag aggagcgccg ccgagtaagg cgcgagcgga acaagctggc 540 tgcggccaag tgcaggaacc ggaggaagga actgaccgac ttcctgcagg cggagactga 600 caaactggaa gatgagaaat ctgggctgca gcgagagatt gaggagctgc agaagcagaa 660 ggagcgccta gagctggtgc tggaagccca ccgacccatc tgcaaaatcc cggaaggagc 720 caaggagggg gacacaggca gtaccagtgg caccagcagc ccaccagccc cctgccgccc 780 tgtaccttgt atctcccttt ccccagggcc tgtgcttgaa cctgaggcac tgcacacccc 840 cacactcatg accacaccct ccctaactcc tttcaccccc agcctggtct tcacctaccc 900 cagcactcct gagccttgtg cctcagctca tcgcaagagt agcagcagca gcggagaccc 960 atcctctgac ccccttggct ctccaaccct cctcgctttg tgaggcgcct gagccctact 1020 ccctgcagat gccaccctag ccaatgtctc ctccccttcc cccaccggtc cagctggcct 1080 ggacagtatc ccacatccaa ctccagcaac ttcttctcca tccctctaat gagactgacc 1140 atattgtgct tcacagtaga gccagcttgg ggccaccaaa gctgcccact gtttctcttg 1200 agctggcctc tctagcacaa tttgcactaa atcagagaca aaatatttcc catttgtgcc 1260 agaggaatcc tggcagccca gagactttgt agatccttag aggtcctctg gagccctaac 1320 cccttccaga tcactgccac actctccatc accctcttcc tgtgatccac ccaaccctat 1380 ctcctgacag aaggtgccac tttacccacc tagaacacta actcaccagc cccactgcca 1440 gcagcagcag gtgattggac caggccattc tgccgccccc tcctgaaccg cacagctcag 1500 gaggcgccct tggcttctgt gatgagctga tctgcggatc tcagctttga gaagccttca 1560 gctccaggga atccaagcct ccacagcgag ggcagctgct atttattttc ctaaagagag 1620 tatttttata caaacctacc aaaatggaat aaaaggcttg aagctgtggc ctgagtgcct 1680 cactggaccc agaggccaat gggagagtat ttggagccct aggtcccagc cttagctcta 1740 cagactcact gcaaaaaaa 1759 <210> 214 <211> 2098 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2098) <223> FST mRNA <400> 214 ttgggaaggg tttccagaag gtgggaaatg tcacctgatt cacactgaac ttttgaaagc 60 tccccacccc caaggagccg cgcacaccct cgctcgcggc cgccctccca cagccccaca 120 cactgggaga ccgcccaccg caaaccgcgg agacccccgt ctagatttaa agcgcggctg 180 cgcccggctt ctgacgtcca ttgaatcgcg cgggcggccg gcggcgagcg cggggctgcg 240 ccgggatcgc tgcgccctcc gccgctggcc tctgcgacgc gcgccgctcg cccgagccac 300 ccgccgccgc gccggctccc cgcgccgctg cgctcctcgc cccgcgcctg cccccaggat 360 ggtccgcgcg aggcaccagc cgggtgggct ttgcctcctg ctgctgctgc tctgccagtt 420 catggaggac cgcagtgccc aggctgggaa ctgctggctc cgtcaagcga agaacggccg 480 ctgccaggtc ctgtacaaga ccgaactgag caaggaggag tgctgcagca ccggccggct 540 gagcacctcg tggaccgagg aggacgtgaa tgacaacaca ctcttcaagt ggatgatttt 600 caacgggggc gcccccaact gcatcccctg taaagaaacg tgtgagaacg tggactgtgg 660 acctgggaaa aaatgccgaa tgaacaagaa gaacaaaccc cgctgcgtct gcgccccgga 720 ttgttccaac atcacctgga agggtccagt ctgcgggctg gatgggaaaa cctaccgcaa 780 tgaatgtgca ctcctaaagg caagatgtaa agagcagcca gaactggaag tccagtacca 840 aggcagatgt aaaaagactt gtcgggatgt tttctgtcca ggcagctcca catgtgtggt 900 ggaccagacc aataatgcct actgtgtgac ctgtaatcgg atttgcccag agcctgcttc 960 ctctgagcaa tatctctgtg ggaatgatgg agtcacctac tccagtgcct gccacctgag 1020 aaaggctacc tgcctgctgg gcagatctat tggattagcc tatgagggaa agtgtatcaa 1080 agcaaagtcc tgtgaagata tccagtgcac tggtgggaaa aaatgtttat gggatttcaa 1140 ggttgggaga ggccggtgtt ccctctgtga tgagctgtgc cctgacagta agtcggatga 1200 gcctgtctgt gccagtgaca atgccactta tgccagcgag tgtgccatga aggaagctgc 1260 ctgctcctca ggtgtgctac tggaagtaaa gcactccgga tcttgcaact gaatctgccc 1320 gtaaaacctg agccattgat tcttcagaac tttctgcagt ttttgacttc atagattatg 1380 ctttaaaaaa atttttttaa cttattgcat aacagcagat gccaaaaaca aaaaaagcat 1440 ctcactgcaa gtcacataaa aatgcaacgc tgtaatatgg ctgtatcaga gggctttgaa 1500 aacatacact gagctgcttc tgcgctgttg ttgtccgtat ttaaacaaca gctcccctgt 1560 attcccccat ctagccattt cggaagacac cgaggaagag gaggaagatg aagaccagga 1620 ctacagcttt cctatatctt ctattctaga gtggtaaact ctctataagt gttcagtgtt 1680 gacatagcct ttgtgcaaaa aaaaaaaaaa aaaaaaagaa aaagaaaaaa agaaaaatat 1740 attgtccata ctgtaaataa gtgtatgctt atttatttgg ggggaaaact atacattaaa 1800 ggacctttgt cctaaagctc tctcccaggc caccttgtta ctcattggac acggagaggc 1860 attcattgtg aggtctactg gatgaggccc atagttgaga cttgtagaca tttatttata 1920 ctgtgtcatg ttttataatt tatacataaa atgtctggtt gactgtatac cttgtttttg 1980 aagaaattta ttcgtgaaag gaagagcagt tgttatttat tgtgaggtct cttgcttgta 2040 aagtaaaagc tttttttcct tgtaaaccat ttaagtccat tccttactat tcactcac 2098 <210> 215 <211> 3275 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3275) <223> HAS2 mRNA <400> 215 gaagtcaaga cgtctggaaa gaattaccca gtcctggctt cgagcagccc attgaaccag 60 agacttgaaa cagccccagc caaagacttt tctcccaatt ctgcgcttcc tgggttctgc 120 tgagtcttcc acaggctttt tttttttttt tttttttttt taagacgaaa aagagatttt 180 ctgttatcgg gggcagaaag actgaagccc aaaaaaaaaa aaaaaaaaaa aagaaaagaa 240 aagaaaaaag aaaagttaat ttatttttaa agcataattt ttttaagaat tagactgaag 300 tgcaacggaa acataaagag aatattagtg aaattatttt ttaaagtggg gaagaatcaa 360 acatttaaga ctcccctatc ctttttaaat gttgttttta aatttcttat tttttttggc 420 cggtcgtctc aaattcatct gatctcttat tacctcaatt ttggaaactg cccgccaccg 480 accctccggg accacacaga caggctgagg acgactttat gaccaagagc tgaacaagat 540 gcattgtgag aggtttctat gtatcctgag aataattgga accacactct ttggagtctc 600 tctcctcctt ggaatcacag ctgcttatat tgttggctac cagtttatcc aaacggataa 660 ttactatttc tcttttggac tgtatggtgc ctttttggca tcacacctca tcatccaaag 720 cctgtttgcc tttttggagc accgaaaaat gaaaaaatcc ctagaaaccc ccataaagtt 780 gaacaaaaca gttgcccttt gcatcgctgc ctatcaagaa gatccagact acttaaggaa 840 atgtttgcaa tctgtgaaaa ggctaaccta ccctgggatt aaagttgtca tggtcataga 900 tgggaactca gaagatgacc tttacatgat ggacatcttc agtgaagtca tgggcagaga 960 caaatcagcc acttatatct ggaagaacaa cttccacgaa aagggtcccg gtgagacaga 1020 tgagtcacat aaagaaagct cgcaacacgt aacgcaattg gtcttgtcca acaaaagtat 1080 ctgcatcatg caaaaatggg gtggaaaaag agaagtcatg tacacagcct tcagagcact 1140 gggacgaagt gtggattatg tacaggtttg tgattcagac actatgcttg acccagcctc 1200 atctgtggag atggtaaaag ttttagaaga agatcccatg gttggaggtg ttgggggaga 1260 tgtccagatt ttaaacaagt acgattcctg gatctcattc ctcagcagtg taagatattg 1320 gatggctttt aatatagaaa gggcctgtca gtcttatttt gggtgtgttc agtgcattag 1380 tggacctctg ggaatgtaca gaaactcctt gttgcatgag tttgtggaag attggtacaa 1440 tcaagaattt atgggcaacc aatgtagctt tggtgatgac aggcatctca cgaaccgggt 1500 gctgagcctg ggctatgcaa caaaatacac agctcgatct aagtgcctta ctgaaacacc 1560 tatagaatat ctcagatggc taaaccagca gacccgttgg agcaagtcct acttccgaga 1620 atggctgtac aatgcaatgt ggtttcacaa acatcacttg tggatgacct acgaagcgat 1680 tatcactgga ttctttcctt tctttctcat tgccacagta atccagctct tctaccgggg 1740 taaaatttgg aacattctcc tcttcttgtt aactgtccag ctagtaggtc tcataaaatc 1800 atcttttgcc agctgcctta gaggaaatat cgtcatggtc ttcatgtctc tctactcagt 1860 gttatacatg tcgagtttac ttcccgccaa gatgtttgca attgcaacaa taaacaaagc 1920 tgggtggggc acatcaggaa ggaaaaccat tgttgttaat ttcataggac tcattccagt 1980 atcagtttgg tttacaatcc tcctgggtgg tgtgattttc accatttata aggagtctaa 2040 aaggccattt tcagaatcca aacagacagt tctaattgtt ggaacgttgc tctatgcatg 2100 ctattgggtc atgcttttga cgctgtatgt agttctcatc aataagtgtg gcaggcggaa 2160 gaagggacaa caatatgaca tggtgcttga tgtatgatct tccatgtttt gacgtttgca 2220 gtcacacaca acaccttagt tcctctaggg gctgtacagt attgtggcat cagataatgc 2280 caccaaagga gacatatcac tgctgctggg acttgaacaa agacatttat atgggtttat 2340 tttcattctg ccaaagtaaa acaatacatc aacaagaaga aactcagatt taacctgtta 2400 tttctatgaa aatgggatga attctttgtt tatgcacttt ttccttactg tgcatccgcc 2460 tgaaagtgtt ttgccctata tacctcacta gccatgcttt atgtgggtta tcatggaaga 2520 aaaggatttt ggaaactcaa ggaaaagttc tttcaaccta tacaacctaa cttatggact 2580 gttttgatag atgataattt ttttttttta ggaaggattt tctttttaac tttaccaaat 2640 gaaatgccaa aggaagtttt aaaggccgtt ggctgtgctg tattttgata taattgtact 2700 gtgtttttaa attttgtatg ccaatcttaa agacaaattt tgcatattct ctattttact 2760 tttctgccaa aataaacctg ttcttccttt tttaaaataa aataagttct taaaaaattt 2820 atacttaaaa aatcctgccc aaaatgtgaa gcttggttga ctgatgttca tgatagaaag 2880 aataaaatgt ttctctctct ctacctttta aaattgaata gtttatttct gtgaaagaag 2940 tatttaaact ttcaatattt taactttttg tttttatttc ttttagaaaa ggccaatata 3000 cctatcacac tttggaagta aaaatacaca ctttcgtgtg tacctaaaaa aaaaatcgtt 3060 gaaaatcaag gccaaaggta gtgcaatttt ttcattaaga tttaaaaaaa agggaatgat 3120 agtctttgaa agaaaacagt aggcatccag cactggacaa aacatgggta tcaaagatga 3180 ataatctttg gagattctgg cagtgttttc ccagaacaag tcaagtggaa agtggagaaa 3240 ttatctgtat aattttggac acatacaatg cagtt 3275 <210> 216 <211> 2381 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2381) <223> HBEGF mRNA <400> 216 attcggccga aggagctacg cgggccacgc tgctggctgg cctgacctag gcgcgcgggg 60 tcgggcggcc gcgcgggcgg gctgagtgag caagacaaga cactcaagaa gagcgagctg 120 cgcctgggtc ccggccaggc ttgcacgcag aggcgggcgg cagacggtgc ccggcggaat 180 ctcctgagct ccgccgccca gctctggtgc cagcgcccag tggccgccgc ttcgaaagtg 240 actggtgcct cgccgcctcc tctcggtgcg ggaccatgaa gctgctgccg tcggtggtgc 300 tgaagctctt tctggctgca gttctctcgg cactggtgac tggcgagagc ctggagcggc 360 ttcggagagg gctagctgct ggaaccagca acccggaccc tcccactgta tccacggacc 420 agctgctacc cctaggaggc ggccgggacc ggaaagtccg tgacttgcaa gaggcagatc 480 tggacctttt gagagtcact ttatcctcca agccacaagc actggccaca ccaaacaagg 540 aggagcacgg gaaaagaaag aagaaaggca aggggctagg gaagaagagg gacccatgtc 600 ttcggaaata caaggacttc tgcatccatg gagaatgcaa atatgtgaag gagctccggg 660 ctccctcctg catctgccac ccgggttacc atggagagag gtgtcatggg ctgagcctcc 720 cagtggaaaa tcgcttatat acctatgacc acacaaccat cctggccgtg gtggctgtgg 780 tgctgtcatc tgtctgtctg ctggtcatcg tggggcttct catgtttagg taccatagga 840 gaggaggtta tgatgtggaa aatgaagaga aagtgaagtt gggcatgact aattcccact 900 gagagagact tgtgctcaag gaatcggctg gggactgcta cctctgagaa gacacaaggt 960 gatttcagac tgcagagggg aaagacttcc atctagtcac aaagactcct tcgtccccag 1020 ttgccgtcta ggattgggcc tcccataatt gctttgccaa aataccagag ccttcaagtg 1080 ccaaacagag tatgtccgat ggtatctggg taagaagaaa gcaaaagcaa gggaccttca 1140 tgcccttctg attcccctcc accaaacccc acttcccctc ataagtttgt ttaaacactt 1200 atcttctgga ttagaatgcc ggttaaattc catatgctcc aggatctttg actgaaaaaa 1260 aaaaagaaga agaagaagga gagcaagaag gaaagatttg tgaactggaa gaaagcaaca 1320 aagattgaga agccatgtac tcaagtacca ccaagggatc tgccattggg accctccagt 1380 gctggatttg atgagttaac tgtgaaatac cacaagcctg agaactgaat tttgggactt 1440 ctacccagat ggaaaaataa caactatttt tgttgttgtt gtttgtaaat gcctcttaaa 1500 ttatatattt attttattct atgtatgtta atttatttag tttttaacaa tctaacaata 1560 atatttcaag tgcctagact gttactttgg caatttcctg gccctccact cctcatcccc 1620 acaatctggc ttagtgccac ccacctttgc cacaaagcta ggatggttct gtgacccatc 1680 tgtagtaatt tattgtctgt ctacatttct gcagatcttc cgtggtcaga gtgccactgc 1740 gggagctctg tatggtcagg atgtaggggt taacttggtc agagccactc tatgagttgg 1800 acttcagtct tgcctaggcg attttgtcta ccatttgtgt tttgaaagcc caaggtgctg 1860 atgtcaaagt gtaacagata tcagtgtctc cccgtgtcct ctccctgcca agtctcagaa 1920 gaggttgggc ttccatgcct gtagctttcc tggtccctca cccccatggc cccaggccca 1980 cagcgtggga actcactttc ccttgtgtca agacatttct ctaactcctg ccattcttct 2040 ggtgctactc catgcagggg tcagtgcagc agaggacagt ctggagaagg tattagcaaa 2100 gcaaaaggct gagaaggaac agggaacatt ggagctgact gttcttggta actgattacc 2160 tgccaattgc taccgagaag gttggaggtg gggaaggctt tgtataatcc cacccacctc 2220 accaaaacga tgaagttatg ctgtcatggt cctttctgga agtttctggt gccatttctg 2280 aactgttaca acttgtattt ccaaacctgg ttcatattta tactttgcaa tccaaataaa 2340 gataaccctt attccataaa aaaaaaaaaa aaaaaaaaaa a 2381 <210> 217 <211> 5834 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(5834) <223> HGF mRNA <400> 217 aggcactgac tccgaacagg attctttcac ccaggcatct cctccagagg gatccgccag 60 cccgtccagc agcaccatgt gggtgaccaa actcctgcca gccctgctgc tgcagcatgt 120 cctcctgcat ctcctcctgc tccccatcgc catcccctat gcagagggac aaaggaaaag 180 aagaaataca attcatgaat tcaaaaaatc agcaaagact accctaatca aaatagatcc 240 agcactgaag ataaaaacca aaaaagtgaa tactgcagac caatgtgcta atagatgtac 300 taggaataaa ggacttccat tcacttgcaa ggcttttgtt tttgataaag caagaaaaca 360 atgcctctgg ttccccttca atagcatgtc aagtggagtg aaaaaagaat ttggccatga 420 atttgacctc tatgaaaaca aagactacat tagaaactgc atcattggta aaggacgcag 480 ctacaaggga acagtatcta tcactaagag tggcatcaaa tgtcagccct ggagttccat 540 gataccacac gaacacagct ttttgccttc gagctatcgg ggtaaagacc tacaggaaaa 600 ctactgtcga aatcctcgag gggaagaagg gggaccctgg tgtttcacaa gcaatccaga 660 ggtacgctac gaagtctgtg acattcctca gtgttcagaa gttgaatgca tgacctgcaa 720 tggggagagt tatcgaggtc tcatggatca tacagaatca ggcaagattt gtcagcgctg 780 ggatcatcag acaccacacc ggcacaaatt cttgcctgaa agatatcccg acaagggctt 840 tgatgataat tattgccgca atcccgatgg ccagccgagg ccatggtgct atactcttga 900 ccctcacacc cgctgggagt actgtgcaat taaaacatgc gctgacaata ctatgaatga 960 cactgatgtt cctttggaaa caactgaatg catccaaggt caaggagaag gctacagggg 1020 cactgtcaat accatttgga atggaattcc atgtcagcgt tgggattctc agtatcctca 1080 cgagcatgac atgactcctg aaaatttcaa gtgcaaggac ctacgagaaa attactgccg 1140 aaatccagat gggtctgaat caccctggtg ttttaccact gatccaaaca tccgagttgg 1200 ctactgctcc caaattccaa actgtgatat gtcacatgga caagattgtt atcgtgggaa 1260 tggcaaaaat tatatgggca acttatccca aacaagatct ggactaacat gttcaatgtg 1320 ggacaagaac atggaagact tacatcgtca tatcttctgg gaaccagatg caagtaagct 1380 gaatgagaat tactgccgaa atccagatga tgatgctcat ggaccctggt gctacacggg 1440 aaatccactc attccttggg attattgccc tatttctcgt tgtgaaggtg ataccacacc 1500 tacaatagtc aatttagacc atcccgtaat atcttgtgcc aaaacgaaac aattgcgagt 1560 tgtaaatggg attccaacac gaacaaacat aggatggatg gttagtttga gatacagaaa 1620 taaacatatc tgcggaggat cattgataaa ggagagttgg gttcttactg cacgacagtg 1680 tttcccttct cgagacttga aagattatga agcttggctt ggaattcatg atgtccacgg 1740 aagaggagat gagaaatgca aacaggttct caatgtttcc cagctggtat atggccctga 1800 aggatcagat ctggttttaa tgaagcttgc caggcctgct gtcctggatg attttgttag 1860 tacgattgat ttacctaatt atggatgcac aattcctgaa aagaccagtt gcagtgttta 1920 tggctggggc tacactggat tgatcaacta tgatggccta ttacgagtgg cacatctcta 1980 tataatggga aatgagaaat gcagccagca tcatcgaggg aaggtgactc tgaatgagtc 2040 tgaaatatgt gctggggctg aaaagattgg atcaggacca tgtgaggggg attatggtgg 2100 cccacttgtt tgtgagcaac ataaaatgag aatggttctt ggtgtcattg ttcctggtcg 2160 tggatgtgcc attccaaatc gtcctggtat ttttgtccga gtagcatatt atgcaaaatg 2220 gatacacaaa attattttaa catataaggt accacagtca tagctgaagt aagtgtgtct 2280 gaagcaccca ccaatacaac tgtcttttac atgaagattt cagagaatgt ggaatttaaa 2340 atgtcactta caacaatcct aagacaacta ctggagagtc atgtttgttg aaattctcat 2400 taatgtttat gggtgttttc tgttgttttg tttgtcagtg ttattttgtc aatgttgaag 2460 tgaattaagg tacatgcaag tgtaataaca tatctcctga agatacttga atggattaaa 2520 aaaacacaca ggtatatttg ctggatgata aagatttcat gggaaaaaaa atcaattaat 2580 ctgtctaagc tgctttctga tgttggtttc ttaataatga gtaaaccaca aattaaatgt 2640 tattttaacc tcaccaaaac aatttatacc ttgtgtccct aaattgtagc cctatattaa 2700 attatattac atttcatatg ctatatgtta tagttcattc atttctcttc accatgtatc 2760 ctgcaatact ggtacacgaa cacacttttt acaaaaccac atacccatgt acacatgcct 2820 aggtacacat gtgcatgcac tacagtttaa attatggtgt acctaatgta acccctaaat 2880 attttagaag tatgtaccta tagttttacc tcaaaaaaac cagaaatctc taaagaccag 2940 tagaaatatt aaaaaatgat gcaagatcaa aatgattagc taattctcca tacataatct 3000 gcagatgatc ttctttggtt ggcatttcag gtgtggccat cacccagagt taaataacac 3060 ctaatctagg tgtttacatg tattcattat cctagttatt tcatgtagtt tctaattctt 3120 aaaggaaaga gggtaatagt tctatttgtg taatttgttt cctccaaact taaggccact 3180 tatttacaca agatatttgt agatctattt tcctaaagca tttcttaagt gctcagatca 3240 gtatctaatt gaagaagttt aaaagtgttt tggtcattaa aaatgtactt aaataggtta 3300 aatctaagcc ttgctgctgt gattggcttc tagctcactg cctttaaatt ttaaaaaatt 3360 taagaggaaa atttccaagt ctccaaagtt ttataaatac ccttcatcaa gtcatgcatt 3420 aaagtatata ttggagaaaa aaataaaaat acttttctca acctggaaga ttttagccta 3480 ataaagcttt tttgaagtaa aagacaactt gtaaaaggaa agaaactagt ttgtctcaac 3540 tctgtattca tttatttttt ttttgaagta gagtggaatc tgttgaatca gatattttat 3600 caagatatgt ttattttttc ttatttcatt ttacaaagtt cactcctaat gccatatgta 3660 acagacattt aaattttgtg ttctgtataa cagccaaatt atcatattta tcattgtatt 3720 tgtcatgctt agctaaagat catgtatttg ttgagaaata gaataacaaa aagtaatagg 3780 ataggctttg aatttttgca gaaatcttcc tgtacaaaac acctttaaaa ataatttttt 3840 gaatggtgtg aatccagtag tcccatttct ctgacttagt tttcttgagt gatttttatc 3900 aaggccaagt ccccaaacaa ttccctacca gctctttaga gtactgttca atctggacta 3960 aaatggtttt aagtttatgg agagcttagt ccacagaata tagggcggcg agtccagaaa 4020 tgcttataca attttttttt cataataaga tatgtgctgg catcaagaaa cttaaagtgg 4080 aagcaaaaag acatccaact agttgctggt ctctatcatc ttatctgatg gtatttctat 4140 tttccttata taatacacca ttttagtaag aactcctaga aatttcaaga gcatattgcc 4200 aaaatataaa gtatatttca tagtttcttc tggctgaacc agtgaaattt tattattgca 4260 tattaatgat atttgtaaaa cttttataaa aattgtcata attttaaata ctcacatttt 4320 aaaaatactt ctttaatgac tcttcctcta aatttcctgg aaatacagat aaagattagc 4380 tagatacaag atacagctaa gtatttagac attttgaggc tagtattttt cattttatta 4440 aaggctaaaa acaataccac caataaatca tcaaacaaac cgtacaaagt aattctctct 4500 ttgggaggct cctttcgtga tagagggaca tgggtggaat tgacaatgaa acttagatga 4560 acaaggtcca tgttatttta ggtggtagaa cagggtagag tcatgtcatt atttgctggt 4620 ggaagacact atttaccagg tgttctttgc tgaataaatc attaaacatt tttaaaaatc 4680 caacaatcca ctttattttg tgtcattgac aaaaggatct tttaaatcag aaggtttcaa 4740 tgcaattttt ggtttggctg tttgaataat ggttatgtac tgttataatt gtagacattt 4800 tctcacgtct accaggaatt gaagtgtaaa actaaaatat ttttcataat gcctctgccg 4860 tgcagaagga atgataatcc ttttgtatac ttctttaatt ttattgtaaa atgtgtaatg 4920 acttttacct atatgctgtg ggcaggtcct cagtaaaatc tattgagtca atttctagta 4980 ttaacaggct tttgcttgct atctaagtgt ttcaaattat gggaagtgtg agacactgga 5040 aggcaagaaa attaacaata atggcatgtg atagcaaaat tgtatttcac ttattcctgt 5100 gaatatttct tgttggtacc aatggtactg tacaaagtga atgttatagc cacaacattc 5160 tcttgaaaag aacactgtca agaagtggga aattgctgtc aggcatttca ttgttgtttt 5220 taaacttttt taaaagaaat actggttttg caatatagag atcatgtggt aaagaatttt 5280 aataagatct tatactaaaa agccttaaat caatttattg agattcaaaa aatactatta 5340 taattaatta catcccatac atataggcaa actcatttaa aaaataaaac taattttggt 5400 aaaagtacat ggcctttgtt tttaaaatac ataattttaa aataaatcac ttgtcatgat 5460 aaagtccaaa aagaagttat cattcaacat tcaactaagg ttggagctaa gaatttacta 5520 atacaaaaaa agttaaaatt ttttggacca tatatatctt gacagtgtaa cttttaagta 5580 ggttcatttc catttgcaca gaaagtttct gtctttagga aactgaaaat gaaatactgt 5640 ggatgctatg actgtttgtc ttgtatgtaa ataggaaatt aataagctgc ctattgagtg 5700 gtatagctgt atgcttaccc aaaaaaggga acactgtggt tatgacttgt attataaact 5760 ttctgtagtt aataaagttg ttatttttat aaccatgatt atattattat tattaataaa 5820 atattttatc aaaa 5834 <210> 218 <211> 4150 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4150) <223> HMGA2 mRNA <400> 218 cttgaatctt ggggcaggaa ctcagaaaac ttccagcccg ggcagcgcgc gcttggtgca 60 agactcagga gctagcagcc cgtccccctc cgactctccg gtgccgccgc tgcctgctcc 120 cgccacccta ggaggcgcgg tgccacccac tactctgtcc tctgcctgtg ctccgtgccc 180 gaccctatcc cggcggagtc tccccatcct cctttgcttt ccgactgccc aaggcacttt 240 caatctcaat ctcttctctc tctctctctc tctctctctc tctctctctc tctctctctc 300 tctctctctc gcagggtggg gggaagagga ggaggaattc tttccccgcc taacatttca 360 agggacacaa ttcactccaa gtctcttccc tttccaagcc gcttccgaag tgctcccggt 420 gcccgcaact cctgatccca acccgcgaga ggagcctctg cgacctcaaa gcctctcttc 480 cttctccctc gcttccctcc tcctcttgct acctccacct ccaccgccac ctccacctcc 540 ggcacccacc caccgccgcc gccgccaccg gcagcgcctc ctcctctcct cctcctcctc 600 ccctcttctc tttttggcag ccgctggacg tccggtgttg atggtggcag cggcggcagc 660 ctaagcaaca gcagccctcg cagcccgcca gctcgcgctc gccccgccgg cgtccccagc 720 cctatcacct catctcccga aaggtgctgg gcagctccgg ggcggtcgag gcgaagcggc 780 tgcagcggcg gtagcggcgg cgggaggcag gatgagcgca cgcggtgagg gcgcggggca 840 gccgtccact tcagcccagg gacaacctgc cgccccagcg cctcagaaga gaggacgcgg 900 ccgccccagg aagcagcagc aagaaccaac cggtgagccc tctcctaaga gacccagggg 960 aagacccaaa ggcagcaaaa acaagagtcc ctctaaagca gctcaaaaga aagcagaagc 1020 cactggagaa aaacggccaa gaggcagacc taggaaatgg ccacaacaag ttgttcagaa 1080 gaagcctgct caggaggaaa ctgaagagac atcctcacaa gagtctgccg aagaggacta 1140 gggggcgcca acgttcgatt tctacctcag cagcagttgg atcttttgaa gggagaagac 1200 actgcagtga ccacttattc tgtattgcca tggtctttcc actttcatct ggggtggggt 1260 ggggtggggt gggggagggg ggggtggggt ggggagaaat cacataacct taaaaaggac 1320 tatattaatc accttctttg taatcccttc acagtcccag gtttagtgaa aaactgctgt 1380 aaacacaggg gacacagctt aacaatgcaa cttttaatta ctgttttctt ttttcttaac 1440 ctactaatag tttgttgatc tgataagcaa gagtgggcgg gtgagaaaaa ccgaattggg 1500 tttagtcaat cactgcactg catgcaaaca agaaacgtgt cacacttgtg acgtcgggca 1560 ttcatatagg aagaacgcgg tgtgtaacac tgtgtacacc tcaaatacca ccccaaccca 1620 ctccctgtag tgaatcctct gtttagaaca ccaaagataa ggactagata ctactttctc 1680 tttttcgtat aatcttgtag acacttactt gatgattttt aactttttat ttctaaatga 1740 gacgaaatgc tgatgtatcc tttcattcag ctaacaaact agaaaaggtt atgttcattt 1800 ttcaaaaagg gaagtaagca aacaaatatt gccaactctt ctatttatgg atatcacaca 1860 tatcagcagg agtaataaat ttactcacag cacttgtttt caggacaaca cttcattttc 1920 aggaaatcta cttcctacag agccaaaatg ccatttagca ataaataaca cttgtcagcc 1980 tcagagcatt taaggaaact agacaagtaa aattatcctc tttgtaattt aatgaaaagg 2040 tacaacagaa taatgcatga tgaactcacc taattatgag gtgggaggag cgaaatctaa 2100 atttcttttg ctatagttat acatcaattt aaaaagcaaa aaaaaaaaag gggggggcaa 2160 tctctctctg tgtctttctc tctctctctt cctctccctc tctcttttca ttgtgtatca 2220 gtttccatga aagacctgaa taccacttac ctcaaattaa gcatatgtgt tacttcaagt 2280 aatacgtttt gacataagat ggttgaccaa ggtgcttttc ttcggcttga gttcaccatc 2340 tcttcattca aactgcactt ttagccagag atgcaatata tccccactac tcaatactac 2400 ctctgaatgt tacaacgaat ttacagtcta gtacttatta catgctgcta tacacaagca 2460 atgcaagaaa aaaacttact gggtaggtga ttctaatcat ctgcagttct ttttgtacac 2520 ttaattacag ttaaagaagc aatctcctta ctgtgtttca gcatgactat gtatttttct 2580 atgttttttt aattaaaaat ttttaaaata cttgtttcag cttctctgct agatttctac 2640 attaacttga aaatttttta accaagtcgc tcctaggttc ttaaggataa ttttcctcaa 2700 tcacactaca catcacacaa gatttgactg taatatttaa atattaccct ccaagtctgt 2760 acctcaaatg aattctttaa ggagatggac taattgactt gcaaagacct acctccagac 2820 ttcaaaagga atgaacttgt tacttgcagc attcatttgt tttttcaatg tttgaaatag 2880 ttcaaactgc agctaaccct agtcaaaact atttttgtaa aagacatttg atagaaagga 2940 acacgttttt acatactttt gcaaaataag taaataataa ataaaataaa agccaacctt 3000 caaagaaact tgaagctttg taggtgagat gcaacaagcc ctgcttttgc ataatgcaat 3060 caaaaatatg tgtttttaag attagttgaa tataagaaaa tgcttgacaa atattttcat 3120 gtattttaca caaatgtgat ttttgtaata tgtctcaacc agatttattt taaacgcttc 3180 ttatgtagag tttttatgcc tttctctcct agtgagtgtg ctgacttttt aacatggtat 3240 tatcaactgg gccaggaggt agtttctcat gacggctttt gtcagtatgg cttttagtac 3300 tgaagccaaa tgaaactcaa aaccatctct cttccagctg cttcagggag gtagtttcaa 3360 aggccacata cctctctgag actggcagat cgctcactgt tgtgaatcac caaaggagct 3420 atggagagaa ttaaaactca acattactgt taactgtgcg ttaaataagc aaataaacag 3480 tggctcataa aaataaaagt cgcattccat atctttggat gggcctttta gaaacctcat 3540 tggccagctc ataaaatgga agcaattgct catgttggcc aaacatggtg caccgagtga 3600 tttccatctc tggtaaagtt acacttttat ttcctgtatg ttgtacaatc aaaacacact 3660 actacctctt aagtcccagt atacctcatt tttcatactg aaaaaaaaag cttgtggcca 3720 atggaacagt aagaacatca taaaattttt atatatatag tttatttttg tgggagataa 3780 attttatagg actgttcttt gctgttgttg gtcgcagcta cataagactg gacatttaac 3840 ttttctacca tttctgcaag ttaggtatgt ttgcaggaga aaagtatcaa gacgtttaac 3900 tgcagttgac tttctccctg ttcctttgag tgtcttctaa ctttattctt tgttctttat 3960 gtagaattgc tgtctatgat tgtactttga atcgcttgct tgttgaaaat atttctctag 4020 tgtattatca ctgtctgttc tgcacaataa acataacagc ctctgtgatc cccatgtgtt 4080 ttgattcctg ctctttgtta cagttccatt aaatgagtaa taaagtttgg tcaaaacaga 4140 aaaaaaaaaa 4150 <210> 219 <211> 2967 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2967) <223> ICAM1 mRNA <400> 219 gagctcctct gctactcaga gttgcaacct cagcctcgct atggctccca gcagcccccg 60 gcccgcgctg cccgcactcc tggtcctgct cggggctctg ttcccaggac ctggcaatgc 120 ccagacatct gtgtccccct caaaagtcat cctgccccgg ggaggctccg tgctggtgac 180 atgcagcacc tcctgtgacc agcccaagtt gttgggcata gagaccccgt tgcctaaaaa 240 ggagttgctc ctgcctggga acaaccggaa ggtgtatgaa ctgagcaatg tgcaagaaga 300 tagccaacca atgtgctatt caaactgccc tgatgggcag tcaacagcta aaaccttcct 360 caccgtgtac tggactccag aacgggtgga actggcaccc ctcccctctt ggcagccagt 420 gggcaagaac cttaccctac gctgccaggt ggagggtggg gcaccccggg ccaacctcac 480 cgtggtgctg ctccgtgggg agaaggagct gaaacgggag ccagctgtgg gggagcccgc 540 tgaggtcacg accacggtgc tggtgaggag agatcaccat ggagccaatt tctcgtgccg 600 cactgaactg gacctgcggc cccaagggct ggagctgttt gagaacacct cggcccccta 660 ccagctccag acctttgtcc tgccagcgac tcccccacaa cttgtcagcc cccgggtcct 720 agaggtggac acgcagggga ccgtggtctg ttccctggac gggctgttcc cagtctcgga 780 ggcccaggtc cacctggcac tgggggacca gaggttgaac cccacagtca cctatggcaa 840 cgactccttc tcggccaagg cctcagtcag tgtgaccgca gaggacgagg gcacccagcg 900 gctgacgtgt gcagtaatac tggggaacca gagccaggag acactgcaga cagtgaccat 960 ctacagcttt ccggcgccca acgtgattct gacgaagcca gaggtctcag aagggaccga 1020 ggtgacagtg aagtgtgagg cccaccctag agccaaggtg acgctgaatg gggttccagc 1080 ccagccactg ggcccgaggg cccagctcct gctgaaggcc accccagagg acaacgggcg 1140 cagcttctcc tgctctgcaa ccctggaggt ggccggccag cttatacaca agaaccagac 1200 ccgggagctt cgtgtcctgt atggcccccg actggacgag agggattgtc cgggaaactg 1260 gacgtggcca gaaaattccc agcagactcc aatgtgccag gcttggggga acccattgcc 1320 cgagctcaag tgtctaaagg atggcacttt cccactgccc atcggggaat cagtgactgt 1380 cactcgagat cttgagggca cctacctctg tcgggccagg agcactcaag gggaggtcac 1440 ccgcaaggtg accgtgaatg tgctctcccc ccggtatgag attgtcatca tcactgtggt 1500 agcagccgca gtcataatgg gcactgcagg cctcagcacg tacctctata accgccagcg 1560 gaagatcaag aaatacagac tacaacaggc ccaaaaaggg acccccatga aaccgaacac 1620 acaagccacg cctccctgaa cctatcccgg gacagggcct cttcctcggc cttcccatat 1680 tggtggcagt ggtgccacac tgaacagagt ggaagacata tgccatgcag ctacacctac 1740 cggccctggg acgccggagg acagggcatt gtcctcagtc agatacaaca gcatttgggg 1800 ccatggtacc tgcacaccta aaacactagg ccacgcatct gatctgtagt cacatgacta 1860 agccaagagg aaggagcaag actcaagaca tgattgatgg atgttaaagt ctagcctgat 1920 gagaggggaa gtggtggggg agacatagcc ccaccatgag gacatacaac tgggaaatac 1980 tgaaacttgc tgcctattgg gtatgctgag gccccacaga cttacagaag aagtggccct 2040 ccatagacat gtgtagcatc aaaacacaaa ggcccacact tcctgacgga tgccagcttg 2100 ggcactgctg tctactgacc ccaacccttg atgatatgta tttattcatt tgttatttta 2160 ccagctattt attgagtgtc ttttatgtag gctaaatgaa cataggtctc tggcctcacg 2220 gagctcccag tcctaatcac attcaaggtc accaggtaca gttgtacagg ttgtacactg 2280 caggagagtg cctggcaaaa agatcaaatg gggctgggac ttctcattgg ccaacctgcc 2340 tttccccaga aggagtgatt tttctatcgg cacaaaagca ctatatggac tggtaatggt 2400 tacaggttca gagattaccc agtgaggcct tattcctccc ttccccccaa aactgacacc 2460 tttgttagcc acctccccac ccacatacat ttctgccagt gttcacaatg acactcagcg 2520 gtcatgtctg gacatgagtg cccagggaat atgcccaagc tatgccttgt cctcttgtcc 2580 tgtttgcatt tcactgggag cttgcactat gcagctccag tttcctgcag tgatcagggt 2640 cctgcaagca gtggggaagg gggccaaggt attggaggac tccctcccag ctttggaagc 2700 ctcatccgcg tgtgtgtgtg tgtgtatgtg tagacaagct ctcgctctgt cacccaggct 2760 ggagtgcagt ggtgcaatca tggttcactg cagtcttgac cttttgggct caagtgatcc 2820 tcccacctca gcctcctgag tagctgggac cataggctca caacaccaca cctggcaaat 2880 ttgatttttt ttttttttcc agagacgggg tctcgcaaca ttgcccagac ttcctttgtg 2940 ttagttaata aagctttctc aactgcc 2967 <210> 220 <211> 1237 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1237) <223> IER3 mRNA <400> 220 acttggcctt acactccgct cggctcacca tgtgtcactc tcgcagctgc cacccgacca 60 tgaccatcct gcaggccccg accccggccc cctccaccat cccgggaccc cggcggggct 120 ccggtcctga gatcttcacc ttcgaccctc tcccggagcc cgcagcggcc cctgccgggc 180 gccccagcgc ctctcgcggg caccgaaagc gcagccgcag ggttctctac cctcgagtgg 240 tccggcgcca gctgccagtc gaggaaccga acccagccaa aaggcttctc tttctgctgc 300 tcaccatcgt cttctgccag atcctgatgg ctgaagaggg tgtgccggcg cccctgcctc 360 cagaggacgc ccctaacgcc gcatccctgg cgcccacccc tgtgtccgcc gtcctcgagc 420 cctttaatct gacttcggag ccctcggact acgctctgga cctcagcact ttcctccagc 480 aacacccggc cgccttctaa ctgtgactcc ccgcactccc caaaaagaat ccgaaaaacc 540 acaaagaaac accaggcgta cctggtgcgc gagagcgtat ccccaactgg gacttccgag 600 gcaacttgaa ctcagaacac tacagcggag acgccacccg gtgcttgagg cgggaccgag 660 gcgcacagag accgaggcgc atagagaccg aggcacagcc cagctggggc taggcccggt 720 gggaaggaga gcgtcgttaa tttatttctt attgctccta attaatattt atatgtattt 780 atgtacgtcc tcctaggtga tggagatgtg tacgtaatat ttattttaac ttatgcaagg 840 gtgtgagatg ttccccctgc tgtaaatgca ggtctcttgg tatttattga gctttgtggg 900 actggtggaa gcaggacacc tggaactgcg gcaaagtagg agaagaaatg gggaggactc 960 gggtggggga ggacgtcccg gctgggatga agtctggtgg tgggtcgtaa gtttaggagg 1020 tgactgcatc ctccagcatc tcaactccgt ctgtctactg tgtgagactt cggcggacca 1080 ttaggaatga gatccgtgag atccttccat cttcttgaag tcgcctttag ggtggctgcg 1140 aggtagaggg ttgggggttg gtgggctgtc acggagcgac tgtcgagatc gcctagtatg 1200 ttctgtgaac acaaataaaa ttgatttact gtctgca 1237 <210> 221 <211> 1376 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1376) <223> IL-13RA2 mRNA <400> 221 gtaagaacac tctcgtgagt ctaacggtct tccggatgaa ggctatttga agtcgccata 60 acctggtcag aagtgtgcct gtcggcgggg agagaggcaa tatcaaggtt ttaaatctcg 120 gagaaatggc tttcgtttgc ttggctatcg gatgcttata tacctttctg ataagcacaa 180 catttggctg tacttcatct tcagacaccg agataaaagt taaccctcct caggattttg 240 agatagtgga tcccggatac ttaggttatc tctatttgca atggcaaccc ccactgtctc 300 tggatcattt taaggaatgc acagtggaat atgaactaaa ataccgaaac attggtagtg 360 aaacatggaa gaccatcatt actaagaatc tacattacaa agatgggttt gatcttaaca 420 agggcattga agcgaagata cacacgcttt taccatggca atgcacaaat ggatcagaag 480 ttcaaagttc ctgggcagaa actacttatt ggatatcacc acaaggaatt ccagaaacta 540 aagttcagga tatggattgc gtatattaca attggcaata tttactctgt tcttggaaac 600 ctggcatagg tgtacttctt gataccaatt acaacttgtt ttactggtat gagggcttgg 660 atcatgcatt acagtgtgtt gattacatca aggctgatgg acaaaatata ggatgcagat 720 ttccctattt ggaggcatca gactataaag atttctatat ttgtgttaat ggatcatcag 780 agaacaagcc tatcagatcc agttatttca cttttcagct tcaaaatata gttaaacctt 840 tgccgccagt ctatcttact tttactcggg agagttcatg tgaaattaag ctgaaatgga 900 gcataccttt gggacctatt ccagcaaggt gttttgatta tgaaattgag atcagagaag 960 atgatactac cttggtgact gctacagttg aaaatgaaac atacaccttg aaaacaacaa 1020 atgaaacccg acaattatgc tttgtagtaa gaagcaaagt gaatatttat tgctcagatg 1080 acggaatttg gagtgagtgg agtgataaac aatgctggga aggtgaagac ctatcgaaga 1140 aaactttgct acgtttctgg ctaccatttg gtttcatctt aatattagtt atatttgtaa 1200 ccggtctgct tttgcgtaag ccaaacacct acccaaaaat gattccagaa tttttctgtg 1260 atacatgaag actttccata tcaagagaca tggtattgac tcaacagttt ccagtcatgg 1320 ccaaatgttc aatatgagtc tcaataaact gaatttttct tgcgaatgtt gaaaaa 1376 <210> 222 <211> 2718 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2718) <223> IL-33 mRNA <400> 222 agtctacaga ctcctccgaa cacagagctg cagctcttca gggaagaaat caaaacaaga 60 tcacaagaat actgaaaaat gaagcctaaa atgaagtatt caaccaacaa aatttccaca 120 gcaaagtgga agaacacagc aagcaaagcc ttgtgtttca agctgggaaa atcccaacag 180 aaggccaaag aagtttgccc catgtacttt atgaagctcc gctctggcct tatgataaaa 240 aaggaggcct gttactttag gagagaaacc accaaaaggc cttcactgaa aacaggtaga 300 aagcacaaaa gacatctggt actcgctgcc tgtcaacagc agtctactgt ggagtgcttt 360 gcctttggta tatcaggggt ccagaaatat actagagcac ttcatgattc aagtatcaca 420 ggaatttcac ctattacaga gtatcttgct tctctaagca catacaatga tcaatccatt 480 acttttgctt tggaggatga aagttatgag atatatgttg aagacttgaa aaaagatgaa 540 aagaaagata aggtgttact gagttactat gagtctcaac acccctcaaa tgaatcaggt 600 gacggtgttg atggtaagat gttaatggta accctgagtc ctacaaaaga cttctggttg 660 catgccaaca acaaggaaca ctctgtggag ctccataagt gtgaaaaacc actgccagac 720 caggccttct ttgtccttca taatatgcac tccaactgtg tttcatttga atgcaagact 780 gatcctggag tgtttatagg tgtaaaggat aatcatcttg ctctgattaa agtagactct 840 tctgagaatt tgtgtactga aaatatcttg tttaagctct ctgaaactta gttgatggaa 900 acctgtgagt cttgggttga gtacccaaat gctaccactg gagaaggaat gagagataaa 960 gaaagagaca ggtgacatct aagggaaatg aagagtgctt agcatgtgtg gaatgttttc 1020 catattatgt ataaaaatat tttttctaat cctccagtta ttcttttatt tccctctgta 1080 taactgcatc ttcaatacaa gtatcagtat attaaatagg gtattggtaa agaaacggtc 1140 aacattctaa agagatacag tctgaccttt acttttctct agtttcagtc cagaaagaac 1200 ttcatattta gagctaaggc cactgaggaa agagccatag cttaagtctc tatgtagaca 1260 gggatccatt ttaaagagct acttagagaa ataattttcc acagttccaa acgataggct 1320 caaacactag agctgctagt aaaaagaaga ccagatgctt cacagaatta tcattttttc 1380 aactggaata aaacaccagg tttgtttgta gatgtcttag gcaacactca gagcagatct 1440 cccttactgt caggggatat ggaacttcaa aggcccacat ggcaagccag gtaacataaa 1500 tgtgtgaaaa agtaaagata actaaaaaat ttagaaaaat aaatccagta tttgtaaagt 1560 gaataacttc atttctaatt gtttaatttt taaaattctg atttttatat attgagttta 1620 agcaaggcat tcttacacga ggaagtgaag taaattttag ttcagacata aaatttcact 1680 tattaggaat atgtaacatg ctaaaacttt ttttttttta aagagtactg agtcacaaca 1740 tgttttagag catccaagta ccatataatc caactatcat ggtaaggcca gaaatcttct 1800 aacctaccag agcctagatg agacaccgaa ttaacattaa aatttcagta actgactgtc 1860 cctcatgtcc atggcctacc atcccttctg accctggctt ccagggacct atgtctttta 1920 atactcactg tcacattggg caaagttgct tctaatcctt atttcccatg tgcacaagtc 1980 tttttgtatt ccagcttcct gataacactg cttactgtgg aatattcatt tgacatctgt 2040 ctcttttcat ttcttttaac taccatgccc ttgatatatc ttttgcacct gctgaacttc 2100 atttctgtat cacctgacct ctggatgcca aaacgtttat tctgctttgt ctgttgtaga 2160 attttagata aagctattaa tggcaatatt tttttgctaa acgtttttgt tttttactgt 2220 cactagggca ataaaattta tactcaacca tataataaca ttttttaact actaaaggag 2280 tagtttttat tttaaagtct tagcaatttc tattacaact tttcttagac ttaacactta 2340 tgataaatga ctaacatagt aacagaatct ttatgaaata tgaccttttc tgaaaataca 2400 tacttttaca tttctacttt attgagacct attagatgta agtgctagta gaatataaga 2460 taaaagaggc tgagaattac catacaaggg tattacaact gtaaaacaat ttatctttgt 2520 ttcattgttc tgtcaataat tgttaccaaa gagataaaaa taaaagcaga atgtatatca 2580 tcccatctga aaaacactaa ttattgacat gtgcatctgt acaataaact taaaatgatt 2640 attaaataat caaatatatc tactacattg tttatattat tgaataaagt atattttcca 2700 aatgtaaaaa aaaaaaaa 2718 <210> 223 <211> 1498 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1498) <223> IL-1B mRNA <400> 223 accaaacctc ttcgaggcac aaggcacaac aggctgctct gggattctct tcagccaatc 60 ttcattgctc aagtgtctga agcagccatg gcagaagtac ctgagctcgc cagtgaaatg 120 atggcttatt acagtggcaa tgaggatgac ttgttctttg aagctgatgg ccctaaacag 180 atgaagtgct ccttccagga cctggacctc tgccctctgg atggcggcat ccagctacga 240 atctccgacc accactacag caagggcttc aggcaggccg cgtcagttgt tgtggccatg 300 gacaagctga ggaagatgct ggttccctgc ccacagacct tccaggagaa tgacctgagc 360 accttctttc ccttcatctt tgaagaagaa cctatcttct tcgacacatg ggataacgag 420 gcttatgtgc acgatgcacc tgtacgatca ctgaactgca cgctccggga ctcacagcaa 480 aaaagcttgg tgatgtctgg tccatatgaa ctgaaagctc tccacctcca gggacaggat 540 atggagcaac aagtggtgtt ctccatgtcc tttgtacaag gagaagaaag taatgacaaa 600 atacctgtgg ccttgggcct caaggaaaag aatctgtacc tgtcctgcgt gttgaaagat 660 gataagccca ctctacagct ggagagtgta gatcccaaaa attacccaaa gaagaagatg 720 gaaaagcgat ttgtcttcaa caagatagaa atcaataaca agctggaatt tgagtctgcc 780 cagttcccca actggtacat cagcacctct caagcagaaa acatgcccgt cttcctggga 840 gggaccaaag gcggccagga tataactgac ttcaccatgc aatttgtgtc ttcctaaaga 900 gagctgtacc cagagagtcc tgtgctgaat gtggactcaa tccctagggc tggcagaaag 960 ggaacagaaa ggtttttgag tacggctata gcctggactt tcctgttgtc tacaccaatg 1020 cccaactgcc tgccttaggg tagtgctaag aggatctcct gtccatcagc caggacagtc 1080 agctctctcc tttcagggcc aatccccagc ccttttgttg agccaggcct ctctcacctc 1140 tcctactcac ttaaagcccg cctgacagaa accacggcca catttggttc taagaaaccc 1200 tctgtcattc gctcccacat tctgatgagc aaccgcttcc ctatttattt atttatttgt 1260 ttgtttgttt tattcattgg tctaatttat tcaaaggggg caagaagtag cagtgtctgt 1320 aaaagagcct agtttttaat agctatggaa tcaattcaat ttggactggt gtgctctctt 1380 taaatcaagt cctttaatta agactgaaaa tatataagct cagattattt aaatgggaat 1440 atttataaat gagcaaatat catactgttc aatggttctg aaataaactt cactgaag 1498 <210> 224 <211> 1197 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1197) <223> IL-6 mRNA <400> 224 gtctcaatat tagagtctca acccccaata aatataggac tggagatgtc tgaggctcat 60 tctgccctcg agcccaccgg gaacgaaaga gaagctctat ctcccctcca ggagcccagc 120 tatgaactcc ttctccacaa gcgccttcgg tccagttgcc ttctccctgg ggctgctcct 180 ggtgttgcct gctgccttcc ctgccccagt acccccagga gaagattcca aagatgtagc 240 cgccccacac agacagccac tcacctcttc agaacgaatt gacaaacaaa ttcggtacat 300 cctcgacggc atctcagccc tgagaaagga gacatgtaac aagagtaaca tgtgtgaaag 360 cagcaaagag gcactggcag aaaacaacct gaaccttcca aagatggctg aaaaagatgg 420 atgcttccaa tctggattca atgaggagac ttgcctggtg aaaatcatca ctggtctttt 480 ggagtttgag gtatacctag agtacctcca gaacagattt gagagtagtg aggaacaagc 540 cagagctgtg cagatgagta caaaagtcct gatccagttc ctgcagaaaa aggcaaagaa 600 tctagatgca ataaccaccc ctgacccaac cacaaatgcc agcctgctga cgaagctgca 660 ggcacagaac cagtggctgc aggacatgac aactcatctc attctgcgca gctttaagga 720 gttcctgcag tccagcctga gggctcttcg gcaaatgtag catgggcacc tcagattgtt 780 gttgttaatg ggcattcctt cttctggtca gaaacctgtc cactgggcac agaacttatg 840 ttgttctcta tggagaacta aaagtatgag cgttaggaca ctattttaat tatttttaat 900 ttattaatat ttaaatatgt gaagctgagt taatttatgt aagtcatatt tatattttta 960 agaagtacca cttgaaacat tttatgtatt agttttgaaa taataatgga aagtggctat 1020 gcagtttgaa tatcctttgt ttcagagcca gatcatttct tggaaagtgt aggcttacct 1080 caaataaatg gctaacttat acatattttt aaagaaatat ttatattgta tttatataat 1140 gtataaatgg tttttatacc aataaatggc attttaaaaa attcagcaaa aaaaaaa 1197 <210> 225 <211> 9027 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(9027) <223> IL-6ST mRNA <400> 225 ggatctgaca gtgttccgga gccggggcga gcagccaaaa ggcccgcgga gtcgcgctgg 60 gccgccccgg cgcagctgaa ccgggggccg cgcctgccag gccgacgggt ctggcccagc 120 ctggcgccaa ggggttcgtg cgctgtggag acgcggaggg tcgaggcggc gcggcctgag 180 tgaaacccaa tggaaaaagc atgacattta gaagtagaag acttagcttc aaatccctac 240 tccttcactt actaattttg tgatttggaa atatccgcgc aagatgttga cgttgcagac 300 ttggctagtg caagccttgt ttattttcct caccactgaa tctacaggtg aacttctaga 360 tccatgtggt tatatcagtc ctgaatctcc agttgtacaa cttcattcta atttcactgc 420 agtttgtgtg ctaaaggaaa aatgtatgga ttattttcat gtaaatgcta attacattgt 480 ctggaaaaca aaccatttta ctattcctaa ggagcaatat actatcataa acagaacagc 540 atccagtgtc acctttacag atatagcttc attaaatatt cagctcactt gcaacattct 600 tacattcgga cagcttgaac agaatgttta tggaatcaca ataatttcag gcttgcctcc 660 agaaaaacct aaaaatttga gttgcattgt gaacgagggg aagaaaatga ggtgtgagtg 720 ggatggtgga agggaaacac acttggagac aaacttcact ttaaaatctg aatgggcaac 780 acacaagttt gctgattgca aagcaaaacg tgacaccccc acctcatgca ctgttgatta 840 ttctactgtg tattttgtca acattgaagt ctgggtagaa gcagagaatg cccttgggaa 900 ggttacatca gatcatatca attttgatcc tgtatataaa gtgaagccca atccgccaca 960 taatttatca gtgatcaact cagaggaact gtctagtatc ttaaaattga catggaccaa 1020 cccaagtatt aagagtgtta taatactaaa atataacatt caatatagga ccaaagatgc 1080 ctcaacttgg agccagattc ctcctgaaga cacagcatcc acccgatctt cattcactgt 1140 ccaagacctt aaacctttta cagaatatgt gtttaggatt cgctgtatga aggaagatgg 1200 taagggatac tggagtgact ggagtgaaga agcaagtggg atcacctatg aagatagacc 1260 atctaaagca ccaagtttct ggtataaaat agatccatcc catactcaag gctacagaac 1320 tgtacaactc gtgtggaaga cattgcctcc ttttgaagcc aatggaaaaa tcttggatta 1380 tgaagtgact ctcacaagat ggaaatcaca tttacaaaat tacacagtta atgccacaaa 1440 actgacagta aatctcacaa atgatcgcta tctagcaacc ctaacagtaa gaaatcttgt 1500 tggcaaatca gatgcagctg ttttaactat ccctgcctgt gactttcaag ctactcaccc 1560 tgtaatggat cttaaagcat tccccaaaga taacatgctt tgggtggaat ggactactcc 1620 aagggaatct gtaaagaaat atatacttga gtggtgtgtg ttatcagata aagcaccctg 1680 tatcacagac tggcaacaag aagatggtac cgtgcatcgc acctatttaa gagggaactt 1740 agcagagagc aaatgctatt tgataacagt tactccagta tatgctgatg gaccaggaag 1800 ccctgaatcc ataaaggcat accttaaaca agctccacct tccaaaggac ctactgttcg 1860 gacaaaaaaa gtagggaaaa acgaagctgt cttagagtgg gaccaacttc ctgttgatgt 1920 tcagaatgga tttatcagaa attatactat attttataga accatcattg gaaatgaaac 1980 tgctgtgaat gtggattctt cccacacaga atatacattg tcctctttga ctagtgacac 2040 attgtacatg gtacgaatgg cagcatacac agatgaaggt gggaaggatg gtccagaatt 2100 cacttttact accccaaagt ttgctcaagg agaaattgaa gccatagtcg tgcctgtttg 2160 cttagcattc ctattgacaa ctcttctggg agtgctgttc tgctttaata agcgagacct 2220 aattaaaaaa cacatctggc ctaatgttcc agatccttca aagagtcata ttgcccagtg 2280 gtcacctcac actcctccaa ggcacaattt taattcaaaa gatcaaatgt attcagatgg 2340 caatttcact gatgtaagtg ttgtggaaat agaagcaaat gacaaaaagc cttttccaga 2400 agatctgaaa tcattggacc tgttcaaaaa ggaaaaaatt aatactgaag gacacagcag 2460 tggtattggg gggtcttcat gcatgtcatc ttctaggcca agcatttcta gcagtgatga 2520 aaatgaatct tcacaaaaca cttcgagcac tgtccagtat tctaccgtgg tacacagtgg 2580 ctacagacac caagttccgt cagtccaagt cttctcaaga tccgagtcta cccagccctt 2640 gttagattca gaggagcggc cagaagatct acaattagta gatcatgtag atggcggtga 2700 tggtattttg cccaggcaac agtacttcaa acagaactgc agtcagcatg aatccagtcc 2760 agatatttca cattttgaaa ggtcaaagca agtttcatca gtcaatgagg aagattttgt 2820 tagacttaaa cagcagattt cagatcatat ttcacaatcc tgtggatctg ggcaaatgaa 2880 aatgtttcag gaagtttctg cagcagatgc ttttggtcca ggtactgagg gacaagtaga 2940 aagatttgaa acagttggca tggaggctgc gactgatgaa ggcatgccta aaagttactt 3000 accacagact gtacggcaag gcggctacat gcctcagtga aggactagta gttcctgcta 3060 caacttcagc agtacctata aagtaaagct aaaatgattt tatctgtgaa ttcagatttt 3120 aaaaagtctt cactctctga agatgatcat ttgcccttaa ggacaaaaat gaactgaagt 3180 ttcacatgag ctatttccat tccagaatat ctgggattct actttaagca ctacataaac 3240 tgactttatc ctcagactag ctgaatgatt ttgtgctgtt tcaggatgtt tgcactgaag 3300 aaaaacagaa agcttatctg aaatttataa aactttttgt tttgctacat agaaaacaga 3360 aggtatttga ataataagca gtgatatgct tagtgagcac agctatactg attttgatta 3420 gaatagtcat cagagtggct tagggacagt taatataaaa gaggagcaag gtgtagacca 3480 tcatctactt ctgctaaaat aacttaaaaa gaggtccata ggccataact acatgagccc 3540 agcttttgta atctgacaaa aaaatgagga gcagcttcgt gtatatcagt gtacacggta 3600 ttccttaggt cccttccatt ggtagtgatg ctgcgagtta ttactggaga aaaggaattc 3660 tagagcttta acttggcaga ttaaaagtac tcatttttta ttcatcaata attagtaatc 3720 tcactagttt tcaaaaattt gcatattatt gacaacctct ttgaagatgc atttcacaaa 3780 ctcaacagag tgccatgata agagctaggg atcccccaaa ctatctcaag catctaaaaa 3840 attgccattt ttaaaggctt aaattgtagt agtaaagggg aaaacaggaa gtagtagtaa 3900 aggggaaaaa aaaccaataa agcatctaaa aaattggcat gttaaaaggc ttaaattgct 3960 aatgtgtgta tatatatata tatatataca cacacatatc attgactttt cttaagactt 4020 cagagtactg ggtagatgaa cactttatac agtatatatc ttcagcttaa atttgttttg 4080 agtatttttt ttatttttaa ataagtaggc aaagatttaa atttttttat ttttagtaaa 4140 tgtttgaggc acactaagac aacttgggca atatttgcca aaacaaaaca gaaccccaaa 4200 aaatgtacat cttgttctta gcaaatatca ttattgtaga gacacttaat aaagagatgg 4260 tattttaatg tctgcagttc tgaggtaggg tggaacttag ttctacattg tgatttagga 4320 atttttaaaa ccttttttct tcaagggaga agtgacccag gcctcgagtt tagtgctaaa 4380 gccgctagtg tacttatgct gtcccctaac caccacgtgc gatatggaag cagatgctaa 4440 atataggggt tttcttagaa agtaagagga aattagcaag cgttattagt gattgactac 4500 tgctatcaag tgaattcaaa ggaaacaggt ttttatgcca tatttaagtt acagaaacca 4560 ggcatgctta gaatagtttc tagaggttat tggagaatag aaagctaaga aaacttggta 4620 tacatttaca atggaaatat aattacactt tttactctca gaatattgtt cacattagac 4680 ttcctgttta tcttttatat tcttgcattt atataatgcc tcatcctttc aaagttcttt 4740 cacatattat atgatcttct ttatgaaaaa aatagatgtt tcattctgat atattcagtt 4800 tcccacttta ggcaaaagta gattaataga atgacgaatt caaagtagat gaggaaaatc 4860 aggcacagag aagtaaaggt agggatagac ccaaatttac acaacaagat aatgacatct 4920 ccagctttta agttgatcat caaaggctgg gctggatttg tcttgctgta tgtgtcagga 4980 aatttatacc tattacattt tccattttct caaaatttaa gtcacatgac taatatttag 5040 ctgcaacttt cctcataaca aatagtgtca tgaagaatgt tgtagtgtga agtttgtaca 5100 tttcagggtc agatatacaa tatgaactct taatctacag gaatgagaat ggaggatcat 5160 tgaaggccat gatataaaca aatttgcatg ttgaagcctg tataaaacat ggtacagtga 5220 gtgaatatac ccccatcccc aagaacactt tatacatatt aaatggatat atgattactg 5280 tgcaaaaatt cattctggaa atgaacatat atttgagcac taatatgtaa tgtacacctg 5340 ccctaaggag aaaataaatt ataaaacttt ttacattcaa aattactttc ccaagcatgt 5400 cttagaataa tctatgtgtt gatgcatgta aattgtactt taggtaggca aagaaatctg 5460 gttatttatg taaaaactag tctaataaag ttagttagtg gctttatcac tttaaatctt 5520 tagtgtccaa aagtggtgtt taaagtaata gcacatcaga aaaccttgtc tggacaaaac 5580 tagttcactc actgcttctg cacctgcagt tgctcccttt agggttataa aataatgacc 5640 caaatgttac atgtgttgat attataactt gtcagttact gatgtctgtg gtatcctacc 5700 ctcatctctg aaagggataa tactgaataa ttattagaaa actataaaac ttcacacttt 5760 gtaccattaa aacctaaaat tttaatcttg tcctttttta ctatggatca gtcggcactc 5820 gggaacagca gcaaggaaaa aaagcaaatt tcattcacat gttctgtgtt catacctctt 5880 ctctacctaa ttgttcattt aaatttcagc cttattcctt gataagggat tttaccacat 5940 gaagtcatcc agtgacccta gctcttattg tgaagttagt ggagtatact tagaaatgtt 6000 acaactttaa aatgttacaa aacattcatt aaagctcata tttaaagtag agcatctagt 6060 ttgagaaata gaaatcaatt attaaagatg tcttttttct acccatttaa ctagttaaaa 6120 ccatgacatg taaatgtaga agtagaataa tcatagaatt ccctaaaata tttctgttta 6180 ctaacatata ttgaccaagt acatcaagca ggagagatct tccttcattc tgttatagtc 6240 cacatcattc taattttgct cagttgttat taagagcata ttcctaaacc atacactttt 6300 gtttcaataa agttttattt tgttgagatg aataaaataa caaagttata agctgcataa 6360 gacaaaagtt caattgttca aaaaaaattt actgggatag ctttctatta caggtattgt 6420 tagattatat tgtgctgata agattacttt ctaaaaaatt tgtacttttc tgtaaattaa 6480 aagaatatgg agtcataaaa tggcaagtgt tttaggatta gcctaaaatt ggacattgtc 6540 attgatttca aagaaggtat gaactagcag tcttacagcc taattcttct ttggactggt 6600 ccttggcagc agttcctttt cagactcgat aaacagaatt cagatgatgt aagtcaaaac 6660 aaaactttac aaagccaagc gtattatctt ttgcattaac ctattttttt ccatcataca 6720 tgctactagt atgtgcatta gcatgatatt ctcatataca ttgcattaaa aattaaaagg 6780 tggcagctca gggtgagctc ttctgttgct catttgttcc taaattttta agggcttttt 6840 ctcagtcaat agtttgtaca aactggttag tttaacttca ttacccattt cattaaagtt 6900 gatgggtcgt gtgatgagat gcatttaagg ccgatagtga tagatgtttt ttttatttct 6960 tgaacacagg ctttgtctga atgatgttct tttatctctt gaacacaagc tttgaatgat 7020 aactacaggt tttaagtgct gttacattaa taccataatg tgatgtgtta gaaacaaagg 7080 gatatttcaa aggtagatat ttgaaaattc tctagtctca atatgtatgt gtattgaata 7140 tactctaaaa ataaatgtgc aatttgctag taggacaatg cagtgactga ctagcattag 7200 gtatgtttct tttatatcct agctatgtcc cactttcttc taagtgcaat cctttcatgt 7260 tcacttgctg ttttacccca tctactctaa cttcatttgg aaggcttgtc tagagtatag 7320 catgtatttt tacctttgca gtgaattgca tgtgctaatt gtaaccacag ctatttttat 7380 gttgacataa ctccaaatgt tatattaaat gttctattat atattagctc taatccctta 7440 agtaaatttt aagaaataaa tacttgttca aatttttttt ctgtatgtgg ttactatcat 7500 ctgactatgc atatttgtaa cagcatttat cattagtggt gttagctaaa taagcatctt 7560 agtgtaaatg agatgcttcg tgtgggtttt gtgacatttt aaatgacata atggaatgtg 7620 atttaaaaga aaaccagtac actatcttgg tcttaataac atagaatgga gatggcaaat 7680 ttatccacta gttttccaga tttactattt aatagctgag gtctgaaatc gtagcatcct 7740 ccctcctagt ggacattaaa aaaaaaaaaa aaaaaaaaaa cctacttggt tgtcaagagc 7800 ccaagtatgg aggtgctgcg ccatcttgtg gcctgtctgt gcccaccctg cactctgctg 7860 gagtctccat ccttgttgca gtgagacttg aagttcaaga ttgatacatg gcatcctcct 7920 gctacttctt gaggttacta agtagtatat gaaactaatc agtcagcaag tccacctgga 7980 aggaaaagaa aatctcaact attaatgtgc cttcacattg tgattttgtc taaaaaaatg 8040 tagtgagtca aaaaacccac aagccagcca acagtaactc cttcacatat ataccagagt 8100 ttatagaaat aacatgtcag ctttgggcta tgtgctcctt tgtttaaaat cttctatttg 8160 gttatggctt gtataggctc aagcctgatt tctttaaggt gtggtggctc atcttatcct 8220 aatgtgtatg atagatacag tccatcctgc tttggaaaag attatgtaac tccttgagag 8280 catactcttt ctctagccca aaggcagtga gagagttttc ttgttcagga ttgcttaact 8340 ttccatttaa gctttttctt tttaaattaa tacaaacttc tacactttca aaatacgaaa 8400 tatattacaa ctgcgtatag gctcttccat acttaagtcc agtgcttggg caagttaatg 8460 gagtgaaaga ctacaagcaa agaggaactg aggtagaaaa agaagaatgt gtgaaagcag 8520 caggaagctc agccaactcg aaagcagggt gaacagcttg agtcctgttg ctgctgatcg 8580 gggttggctc ttggacaact tagtaagatc atggaaaggc tgcttgggtt ctccatagaa 8640 aagttctgtc tccatcaagg gaggaaaatg tacctttcaa ctcaaaattc aatatttgtt 8700 tttaaatata gctattttcc ccaaccgcta aagattttca acagatacga agccagagct 8760 tagttttaga aacctgtgga cattcaaacc tgattcttta ttccctgtga ctatggttat 8820 gtcattttac atgtcaaaaa agtgtatcta gaattgtcat ttcttatttt tgagcttttt 8880 ttagtgagaa ttatcccctc acttaaatgg ctttttattt aaacatctgt gcattctgta 8940 tgaaattgta gtctttctgg gataacatgg tgagctatat ggtggtaatc cacacacaca 9000 aaaataaaag ccaaaaaaaa accaaaa 9027 <210> 226 <211> 4643 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4643) <223> IL-7R mRNA <400> 226 gtggttagat aagtataaag ccctagatct aagcttctct gtcttcctcc ctccctccct 60 tcctcttact ctcattcatt tcatacacac tggctcacac atctactctc tctctctatc 120 tctctcagaa tgacaattct aggtacaact tttggcatgg ttttttcttt acttcaagtc 180 gtttctggag aaagtggcta tgctcaaaat ggagacttgg aagatgcaga actggatgac 240 tactcattct catgctatag ccagttggaa gtgaatggat cgcagcactc actgacctgt 300 gcttttgagg acccagatgt caacatcacc aatctggaat ttgaaatatg tggggccctc 360 gtggaggtaa agtgcctgaa tttcaggaaa ctacaagaga tatatttcat cgagacaaag 420 aaattcttac tgattggaaa gagcaatata tgtgtgaagg ttggagaaaa gagtctaacc 480 tgcaaaaaaa tagacctaac cactatagtt aaacctgagg ctccttttga cctgagtgtc 540 gtctatcggg aaggagccaa tgactttgtg gtgacattta atacatcaca cttgcaaaag 600 aagtatgtaa aagttttaat gcacgatgta gcttaccgcc aggaaaagga tgaaaacaaa 660 tggacgcatg tgaatttatc cagcacaaag ctgacactcc tgcagagaaa gctccaaccg 720 gcagcaatgt atgagattaa agttcgatcc atccctgatc actattttaa aggcttctgg 780 agtgaatgga gtccaagtta ttacttcaga actccagaga tcaataatag ctcaggggag 840 atggatccta tcttactaac catcagcatt ttgagttttt tctctgtcgc tctgttggtc 900 atcttggcct gtgtgttatg gaaaaaaagg attaagccta tcgtatggcc cagtctcccc 960 gatcataaga agactctgga acatctttgt aagaaaccaa gaaaaaattt aaatgtgagt 1020 ttcaatcctg aaagtttcct ggactgccag attcataggg tggatgacat tcaagctaga 1080 gatgaagtgg aaggttttct gcaagatacg tttcctcagc aactagaaga atctgagaag 1140 cagaggcttg gaggggatgt gcagagcccc aactgcccat ctgaggatgt agtcatcact 1200 ccagaaagct ttggaagaga ttcatccctc acatgcctgg ctgggaatgt cagtgcatgt 1260 gacgccccta ttctctcctc ttccaggtcc ctagactgca gggagagtgg caagaatggg 1320 cctcatgtgt accaggacct cctgcttagc cttgggacta caaacagcac gctgccccct 1380 ccattttctc tccaatctgg aatcctgaca ttgaacccag ttgctcaggg tcagcccatt 1440 cttacttccc tgggatcaaa tcaagaagaa gcatatgtca ccatgtccag cttctaccaa 1500 aaccagtgaa gtgtaagaaa cccagactga acttaccgtg agcgacaaag atgatttaaa 1560 agggaagtct agagttccta gtctccctca cagcacagag aagacaaaat tagcaaaacc 1620 ccactacaca gtctgcaaga ttctgaaaca ttgctttgac cactcttcct gagttcagtg 1680 gcactcaaca tgagtcaaga gcatcctgct tctaccatgt ggatttggtc acaaggttta 1740 aggtgaccca atgattcagc tatttaaaaa aaaaagagga aagaatgaaa gagtaaagga 1800 aatgattgag gagtgaggaa ggcaggaaga gagcatgaga ggaaagaaag aaaggaaaat 1860 aaaaaatgat agttgccatt attaggattt aatatatatc cagtgctttg caagtgctct 1920 gcgcaccttg tctcactcca tcctgacaat aatcctggga ggtgtgtgca attactacga 1980 ctactctctt ttttatagat cattaaattc agaactaagg agttaagtaa cttgtccaag 2040 ttgttcacac agtgaaggga ggggccaaga tatgatggct gggagtctaa ttgcagttcc 2100 ctgagccatg tgcctttctc ttcactgagg actgccccat tcttgagtgc caaacgtcac 2160 tagtaacagg gtgtgcctag ataatttatg atccaaactg agtcagtttg gaaagtgaaa 2220 gggaaactta catataatcc ctccgggaca atgagcaaaa actaggactg tccccagaca 2280 aatgtgaaca tacatatcat cacttaaatt aaaatggcta tgagaaagaa agagggggag 2340 aaacagtctt gcgggtgtga agtcccatga ccagccatgt caaaagaagg taaagaagtc 2400 aagaaaaagc catgaagccc atttggtttc atttttctga aaataggctc aagagggaat 2460 aaattagaaa ctcacaattt ctcttgtttg ttaccaagac agtgattctc ttgctgctac 2520 cacccaactg catccgtcca tgatctcaga ggaaactgtc gctgaccctg gacatgggta 2580 cgtttgacga gtgagaggag gcatgacccc tcccatgtgt atagacacta ccccaaccta 2640 aattcatccc taaattgtcc caagttctcc agcaatagag gctgccacaa acttcaggga 2700 gaaagagtta caagtacatg caatgagtga actgactgtg gctacaatct tgaagatata 2760 cggaagagac gtattattaa tgcttgacat atatcatctt gcctttcttg gtctagactg 2820 acttctaatg actaactcaa agtcaaggca actgagtaat gtcagctcag caaagtgcag 2880 caaacccatc tcccacaggc ctccaaaccc tggctgttca cagaaccaca aagggcagat 2940 gctgcacaga aaactagaga aggggtcata ggttcatggt tttgtttgag atttgttgct 3000 actgtttttc tgttttgaat tttcttcttt gttctgtttt tactttattt agggggacta 3060 ggtgtttctg atattttagt tttcttgttt gttttgtttt gtgttgtctg tgaatggggt 3120 tttaactgtg gatgaatgga ccttatctgt tggcttaaag gactggtaag atcagaccat 3180 cttattcttc aggtgaatgt tttactttcc aaagtgctct cctctgcacc agcagtaata 3240 aatacaatgc cataatccct taggtttgcc tagtgctttt gcaattttca aagcacttcc 3300 ataagcattc cttccacctc cttgataggc atttatggaa agcctgctac atgtcaatca 3360 tactgttagg cacaggggac ctaaagacac ataaaaggat ggcattctgc ctcataaatt 3420 gcaaaaccta atgaaagtga ctgcttggta aacaaattat tattatatta taaaatgcta 3480 taaaagagcc atattgaaag tgccctgttg gagacagggc aaatgccaca aaaatgatgt 3540 aaatttacat ggaggaaaag tagaatctgc ctggtttgta ggcagcagaa gacatttttc 3600 atcagtgggc aggtgttctt taccttttgt agaaatggga gtcaagtctc aaataggagg 3660 ctccacaaaa tctcatgcca ggtctctgat accttattca cagaagttct ttgaagtatt 3720 tattgttatt ttctttgact tatgggaaaa ctgggacaca ggaagacagg taaattaccc 3780 aacctcacac gttaagtcag aactgggagc cataattttg tatccctggt ataaatagac 3840 aatctcttga agaaatgaag agatgaccat agaaaaacat cgagatatct ccagctctaa 3900 aatcctttgt ttcaatgttg tttggcatat gttatctttg gaatttagtg tctgagcctc 3960 tgtctgttac tgtagtattt aaaatgcatg tattataatc atataatcat aactgctgtt 4020 aattcttgat tatataccta gggacaatgt gtaatgtaag attactaatt ggttctgccc 4080 aatctccttt cagattttat taggaaaaaa aaataaacct cctgatcgga gacaatgtat 4140 taatcagaag tgtaaactgc cagttctata tagcatgaaa tgaaaagaca gctaatttgg 4200 tccaacaaac atgactgggt ctagggcacc caggctgatt cagctgattt cctaccagcc 4260 tttgcctctt ccttcaatgt ggtttccatg ggaatttgct tcagaaaagc caagtatggg 4320 ctgttcagag gtgcacacct gcattttctt agctcttcta gaggggctaa gagacttggt 4380 acgggccagg aagaatatgt ggcagagctc ctggaaatga tgcagattag gtggcatttt 4440 tgtcagctct gtggtttatt gttgggacta ttctttaaaa tatccattgt tcactacagt 4500 gaagatctct gatttaaccg tgtactatcc acatgcatta caaacatttc gcagagctgc 4560 ttagtatata agcgtacaat gtatgtaata accatctcat atttaattaa atggtataga 4620 agaacaaaaa aaaaaaaaaa aaa 4643 <210> 227 <211> 1642 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1642) <223> IL-8 mRNA <400> 227 acaaactttc agagacagca gagcacacaa gcttctagga caagagccag gaagaaacca 60 ccggaaggaa ccatctcact gtgtgtaaac atgacttcca agctggccgt ggctctcttg 120 gcagccttcc tgatttctgc agctctgtgt gaaggtgcag ttttgccaag gagtgctaaa 180 gaacttagat gtcagtgcat aaagacatac tccaaacctt tccaccccaa atttatcaaa 240 gaactgagag tgattgagag tggaccacac tgcgccaaca cagaaattat tgtaaagctt 300 tctgatggaa gagagctctg tctggacccc aaggaaaact gggtgcagag ggttgtggag 360 aagtttttga agagggctga gaattcataa aaaaattcat tctctgtggt atccaagaat 420 cagtgaagat gccagtgaaa cttcaagcaa atctacttca acacttcatg tattgtgtgg 480 gtctgttgta gggttgccag atgcaataca agattcctgg ttaaatttga atttcagtaa 540 acaatgaata gtttttcatt gtaccatgaa atatccagaa catacttata tgtaaagtat 600 tatttatttg aatctacaaa aaacaacaaa taatttttaa atataaggat tttcctagat 660 attgcacggg agaatataca aatagcaaaa ttgaggccaa gggccaagag aatatccgaa 720 ctttaatttc aggaattgaa tgggtttgct agaatgtgat atttgaagca tcacataaaa 780 atgatgggac aataaatttt gccataaagt caaatttagc tggaaatcct ggattttttt 840 ctgttaaatc tggcaaccct agtctgctag ccaggatcca caagtccttg ttccactgtg 900 ccttggtttc tcctttattt ctaagtggaa aaagtattag ccaccatctt acctcacagt 960 gatgttgtga ggacatgtgg aagcacttta agttttttca tcataacata aattattttc 1020 aagtgtaact tattaaccta tttattattt atgtatttat ttaagcatca aatatttgtg 1080 caagaatttg gaaaaataga agatgaatca ttgattgaat agttataaag atgttatagt 1140 aaatttattt tattttagat attaaatgat gttttattag ataaatttca atcagggttt 1200 ttagattaaa caaacaaaca attgggtacc cagttaaatt ttcatttcag ataaacaaca 1260 aataattttt tagtataagt acattattgt ttatctgaaa ttttaattga actaacaatc 1320 ctagtttgat actcccagtc ttgtcattgc cagctgtgtt ggtagtgctg tgttgaatta 1380 cggaataatg agttagaact attaaaacag ccaaaactcc acagtcaata ttagtaattt 1440 cttgctggtt gaaacttgtt tattatgtac aaatagattc ttataatatt atttaaatga 1500 ctgcattttt aaatacaagg ctttatattt ttaactttaa gatgttttta tgtgctctcc 1560 aaattttttt tactgtttct gattgtatgg aaatataaaa gtaaatatga aacatttaaa 1620 atataatttg ttgtcaaagt aa 1642 <210> 228 <211> 4811 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4811) <223> ITGA1 mRNA <400> 228 ggtcctgccc tgcgaaccag cgcggccccc tggcgctgag gctgctccgg ccatggcccc 60 tcggccccgc gcccgcccag gggtcgctgt cgcctgctgc tggctcctca ctgttgttct 120 acgctgctgc gtatcattca atgttgatgt gaaaaattca atgactttca gcggcccggt 180 ggaagacatg tttggatata ctgttcaaca atatgaaaat gaagaaggaa aatgggtgct 240 tattggttct ccgttagttg gccaacccaa aaacagaact ggagatgtct ataagtgtcc 300 agttgggaga ggtgaatcat taccttgtgt aaagttggat ctaccagtta atacatcaat 360 tcccaatgtc acagaagtaa aggagaacat gacatttgga tcaactttag tcaccaaccc 420 aaatggagga tttctggctt gtgggccctt atatgcctat agatgtggac atttgcatta 480 cacaactgga atctgttctg acgtcagccc cacatttcaa gtcgtgaatt ccattgcccc 540 tgtacaagaa tgcagcactc aactggacat agtcatagtg ctggatggtt ccaacagtat 600 ttacccatgg gacagtgtta cagctttttt aaatgacctt cttgaaagaa tggatattgg 660 tcctaaacag acacaggttg gaattgtaca gtatggagaa aacgtgaccc atgagttcaa 720 cctcaataag tattcttcca ccgaagaggt acttgttgca gcaaagaaaa tagtccagag 780 aggtggccgc cagactatga cagctcttgg aatagacaca gcaagaaagg aggcattcac 840 ggaagcccgg ggtgcccgaa gaggagttaa aaaagtcatg gttattgtga cagatggaga 900 gtctcatgac aatcatcgac tgaagaaggt catccaagac tgtgaagatg aaaacattca 960 acggttttcc atagctattc ttggcagcta taaccgagga aatttaagca ctgaaaaatt 1020 tgtggaggaa ataaaatcaa ttgcaagtga acccactgaa aagcatttct tcaatgtctc 1080 tgatgaattg gctctagtca ccattgttaa aactctggga gaaagaatat ttgccctgga 1140 agccacagct gaccagtcag cagcttcatt tgaaatggaa atgtctcaga ctggcttcag 1200 tgctcattat tcacaggact gggtcatgct tggagcagta ggagcctatg attggaatgg 1260 aacagttgtc atgcagaagg ctagtcaaat cataatccct cgaaacacaa cctttaatgt 1320 tgagtctacc aaaaagaatg aaccgcttgc ttcttattta ggttacactg taaactctgc 1380 tactgcttct tctggagatg tgctctatat tgctggacag cctcggtaca atcatacagg 1440 ccaggtcatt atctacagga tggaagatgg aaacatcaaa attctccaga cgctcagtgg 1500 agaacagatt ggttcctact ttggcagtat tttaacaaca actgacattg acaaggattc 1560 taatactgac attcttctag tcggagcccc tatgtacatg ggaacagaga aggaggagca 1620 aggaaaagtg tatgtgtatg ctctcaatca gacaaggttt gaatatcaaa tgagcctgga 1680 acctattaag cagacgtgct gttcatctcg gcagcacaat tcatgcacaa cagaaaacaa 1740 aaatgagcca tgcggggctc gttttggaac tgcaattgct gctgtaaaag acctcaatct 1800 tgatggattt aatgacatcg tgataggagc tccgctggaa gatgatcacg ggggagctgt 1860 gtacatttat catggaagtg gcaagactat aaggaaagag tatgcacaac gtattccatc 1920 aggtggggat ggtaagacac tgaaattttt tggccagtct atccacggag aaatggattt 1980 aaatggtgac ggtctgacag atgtgactat tgggggcctt ggtggtgctg ccctcttctg 2040 gtcccgagat gtggccgtag ttaaagtgac catgaatttt gagccaaata aagtgaatat 2100 tcaaaagaaa aactgccata tggagggaaa ggaaacagta tgcataaatg ctacagtgtg 2160 ttttgatgtg aaattaaagt ctaaagaaga cacgatttat gaagctgatt tgcagtaccg 2220 tgtcacccta gattcactaa gacaaatatc acgaagtttt ttctctggaa ctcaagagag 2280 aaaggttcaa aggaacatca cagttcgaaa atcagaatgc actaagcact ccttctacat 2340 gttggacaag catgactttc aggactctgt gagaataacg ttggacttta atcttaccga 2400 tccagaaaat gggcctgttc ttgatgattc tctaccaaac tcagtacatg aatatattcc 2460 ctttgccaaa gattgtggaa ataaggaaaa atgtatctca gacctcagcc tgcatgtcgc 2520 caccactgaa aaggacctgc tgattgtccg atcccagaat gataagttca acgttagcct 2580 cacagtcaaa aatacaaagg acagtgccta taacaccagg acaatagtgc attattctcc 2640 aaatctagtt ttttcaggaa ttgaggctat ccaaaaagac agttgtgaat ctaatcataa 2700 tatcacatgt aaagttggat atcccttcct gagaagagga gagatggtaa ctttcaaaat 2760 attgtttcag tttaacacat cctatctcat ggaaaatgtg accatttatt taagtgcaac 2820 aagtgacagc gaagaacctc ctgaaaccct ttctgataat gtagtaaaca tttctatccc 2880 ggtaaaatat gaagttggac tacagtttta cagctctgca agtgaatacc acatttcaat 2940 tgctgccaat gagacagtcc ctgaagttat taattctact gaggacattg gaaatgaaat 3000 taatatcttc tacttgatta gaaaaagtgg atcttttcca atgccagagc ttaagctgtc 3060 aatttcattc cccaatatga catcaaatgg ttaccctgtg ctgtacccaa ctggattgtc 3120 atcttctgag aatgcaaact gcagacccca tatctttgag gatcctttca gtatcaactc 3180 tggaaagaaa atgactacat caactgacca tctcaaacga ggcacaattc tggactgcaa 3240 tacatgtaaa tttgctacca tcacatgtaa tctcacttct tctgacatca gccaagtcaa 3300 tgtttcgctt atcttgtgga aaccaacttt tataaaatca tatttttcca gcttaaatct 3360 tactataagg ggagaacttc ggagtgaaaa tgcatctctg gttttaagta gcagcaatca 3420 aaaaagagag cttgctattc aaatatccaa agatgggcta ccgggcagag tgccattatg 3480 ggtcatcctg ctgagtgctt ttgccggatt gttgctgtta atgctgctca ttttagcact 3540 gtggaagatt ggattcttca aaagaccact gaaaaagaaa atggagaaat gaaatatttt 3600 atgaaagaaa ataataacaa ttattcaata atctatcctc aggtttgcct caaatatgtg 3660 acaagaaatg tataattcat gacatagtca tgtaactatg taatccatca gggattcatt 3720 acttggaaaa tgacaggtca tgcattatcc aaaaacaata ccaaaaagac atattttata 3780 aaatgacaaa aaatatttta cataattact catttttgtt gagtaagcaa aattacaaag 3840 tgtttttaaa aaaacctgta caaatatgtt tatgtattaa atcaccatcc aaaatattta 3900 aggaatatat aaaaagattt ttatgatcat agaaacatct attttcaaaa caatataaat 3960 taagcttttc cccttgattc ctgttggata tccatgttca gcatgacagt cagcactcgt 4020 aaatgccaag aaaagaatta cctgaaaaag atcatttctc cctattcaaa tgagaatatt 4080 ttcccttggt agaatccata tacaatatgg attgaaaatt aagtcaccaa gaatacattt 4140 agcatctttg tgttgggttc tatacctaaa aattttccct ccctgcccaa ggtgattgga 4200 aagtactgca attgagctaa aattttatct aggatggaaa atcaggatag actcgtttaa 4260 aaacaagtat attaaatggg ttaaattaag cttttacaga acatgcttaa ttttgatatt 4320 gagctctaaa tgcaaaactc ttttatactg aaaaaacact taaagtagtt ttgtgtggca 4380 tcacagtgat ttgtcatgaa aagccatata tgggggacat gctaaaatgg cttctgaatg 4440 aaatacgaca gcagagaaag atgccactga aatgctgaaa ttatctttgc tgagcagctt 4500 ttgaatgcta agggttccag tatgtgaccc aaagaaagag ttgtctcaac tccttggtac 4560 agggttcatt caaaccccca agctgtgaga gtgtgtttat ttttaatttt ttaaaaggta 4620 tttaatttcc aaccacactt cttatttttt tgaaaagaca attttccatt tcagtattac 4680 attttaccaa gaagtcactg ctttttaggt gtgttgcatc aatatttaaa taaaatccca 4740 gaaatgtatt ttaaagaatt tcaggtttga aaactcaaac caacaggaag atatcaaaaa 4800 aaaaaaaaaa a 4811 <210> 229 <211> 7843 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(7843) <223> ITGA2 mRNA <400> 229 agagaagccc tctggacagc ttctagagtg tgcaggttct cgtatccctc ggccaagggt 60 atcctctgca aacctctgca aacccagcgc aactacggtc ccccggtcag acccaggatg 120 gggccagaac ggacaggggc cgcgccgctg ccgctgctgc tggtgttagc gctcagtcaa 180 ggcattttaa attgttgttt ggcctacaat gttggtctcc cagaagcaaa aatattttcc 240 ggtccttcaa gtgaacagtt tggctatgca gtgcagcagt ttataaatcc aaaaggcaac 300 tggttactgg ttggttcacc ctggagtggc tttcctgaga accgaatggg agatgtgtat 360 aaatgtcctg ttgacctatc cactgccaca tgtgaaaaac taaatttgca aacttcaaca 420 agcattccaa atgttactga gatgaaaacc aacatgagcc tcggcttgat cctcaccagg 480 aacatgggaa ctggaggttt tctcacatgt ggtcctctgt gggcacagca atgtgggaat 540 cagtattaca caacgggtgt gtgttctgac atcagtcctg attttcagct ctcagccagc 600 ttctcacctg caactcagcc ctgcccttcc ctcatagatg ttgtggttgt gtgtgatgaa 660 tcaaatagta tttatccttg ggatgcagta aagaattttt tggaaaaatt tgtacaaggc 720 ctggatatag gccccacaaa gacacaggtg gggttaattc agtatgccaa taatccaaga 780 gttgtgttta acttgaacac atataaaacc aaagaagaaa tgattgtagc aacatcccag 840 acatcccaat atggtgggga cctcacaaac acattcggag caattcaata tgcaagaaaa 900 tatgcttatt cagcagcttc tggtgggcga cgaagtgcta cgaaagtaat ggtagttgta 960 actgacggtg aatcacatga tggttcaatg ttgaaagctg tgattgatca atgcaaccat 1020 gacaatatac tgaggtttgg catagcagtt cttgggtact taaacagaaa cgcccttgat 1080 actaaaaatt taataaaaga aataaaagca atcgctagta ttccaacaga aagatacttt 1140 ttcaatgtgt ctgatgaagc agctctacta gaaaaggctg ggacattagg agaacaaatt 1200 ttcagcattg aaggtactgt tcaaggagga gacaactttc agatggaaat gtcacaagtg 1260 ggattcagtg cagattactc ttctcaaaat gatattctga tgctgggtgc agtgggagct 1320 tttggctgga gtgggaccat tgtccagaag acatctcatg gccatttgat ctttcctaaa 1380 caagcctttg accaaattct gcaggacaga aatcacagtt catatttagg ttactctgtg 1440 gctgcaattt ctactggaga aagcactcac tttgttgctg gtgctcctcg ggcaaattat 1500 accggccaga tagtgctata tagtgtgaat gagaatggca atatcacggt tattcaggct 1560 caccgaggtg accagattgg ctcctatttt ggtagtgtgc tgtgttcagt tgatgtggat 1620 aaagacacca ttacagacgt gctcttggta ggtgcaccaa tgtacatgag tgacctaaag 1680 aaagaggaag gaagagtcta cctgtttact atcaaagagg gcattttggg tcagcaccaa 1740 tttcttgaag gccccgaggg cattgaaaac actcgatttg gttcagcaat tgcagctctt 1800 tcagacatca acatggatgg ctttaatgat gtgattgttg gttcaccact agaaaatcag 1860 aattctggag ctgtatacat ttacaatggt catcagggca ctatccgcac aaagtattcc 1920 cagaaaatct tgggatccga tggagccttt aggagccatc tccagtactt tgggaggtcc 1980 ttggatggct atggagattt aaatggggat tccatcaccg atgtgtctat tggtgccttt 2040 ggacaagtgg ttcaactctg gtcacaaagt attgctgatg tagctataga agcttcattc 2100 acaccagaaa aaatcacttt ggtcaacaag aatgctcaga taattctcaa actctgcttc 2160 agtgcaaagt tcagacctac taagcaaaac aatcaagtgg ccattgtata taacatcaca 2220 cttgatgcag atggattttc atccagagta acctccaggg ggttatttaa agaaaacaat 2280 gaaaggtgcc tgcagaagaa tatggtagta aatcaagcac agagttgccc cgagcacatc 2340 atttatatac aggagccctc tgatgttgtc aactctttgg atttgcgtgt ggacatcagt 2400 ctggaaaacc ctggcactag ccctgccctt gaagcctatt ctgagactgc caaggtcttc 2460 agtattcctt tccacaaaga ctgtggtgag gacggacttt gcatttctga tctagtccta 2520 gatgtccgac aaataccagc tgctcaagaa caacccttta ttgtcagcaa ccaaaacaaa 2580 aggttaacat tttcagtaac gctgaaaaat aaaagggaaa gtgcatacaa cactggaatt 2640 gttgttgatt tttcagaaaa cttgtttttt gcatcattct ccctgccggt tgatgggaca 2700 gaagtaacat gccaggtggc tgcatctcag aagtctgttg cctgcgatgt aggctaccct 2760 gctttaaaga gagaacaaca ggtgactttt actattaact ttgacttcaa tcttcaaaac 2820 cttcagaatc aggcgtctct cagtttccaa gccttaagtg aaagccaaga agaaaacaag 2880 gctgataatt tggtcaacct caaaattcct ctcctgtatg atgctgaaat tcacttaaca 2940 agatctacca acataaattt ttatgaaatc tcttcggatg ggaatgttcc ttcaatcgtg 3000 cacagttttg aagatgttgg tccaaaattc atcttctccc tgaaggtaac aacaggaagt 3060 gttccagtaa gcatggcaac tgtaatcatc cacatccctc agtataccaa agaaaagaac 3120 ccactgatgt acctaactgg ggtgcaaaca gacaaggctg gtgacatcag ttgtaatgca 3180 gatatcaatc cactgaaaat aggacaaaca tcttcttctg tatctttcaa aagtgaaaat 3240 ttcaggcaca ccaaagaatt gaactgcaga actgcttcct gtagtaatgt tacctgctgg 3300 ttgaaagacg ttcacatgaa aggagaatac tttgttaatg tgactaccag aatttggaac 3360 gggactttcg catcatcaac gttccagaca gtacagctaa cggcagctgc agaaatcaac 3420 acctataacc ctgagatata tgtgattgaa gataacactg ttacgattcc cctgatgata 3480 atgaaacctg atgagaaagc cgaagtacca acaggagtta taataggaag tataattgct 3540 ggaatccttt tgctgttagc tctggttgca attttatgga agctcggctt cttcaaaaga 3600 aaatatgaaa agatgaccaa aaatccagat gagattgatg agaccacaga gctcagtagc 3660 tgaaccagca gacctacctg cagtgggaac cggcagcatc ccagccaggg tttgctgttt 3720 gcgtgaatgg atttcttttt aaatcccata ttttttttat catgtcgtag gtaaactaac 3780 ctggtatttt aagagaaaac tgcaggtcag tttggaatga agaaattgtg gggggtgggg 3840 gaggtgcggg gggcaggtag ggaaataata gggaaaatac ctattttata tgatggggga 3900 aaaaaagtaa tctttaaact ggctggccca gagtttacat tctaatttgc attgtgtcag 3960 aaacatgaaa tgcttccaag catgacaact tttaaagaaa aatatgatac tctcagattt 4020 taagggggaa aactgttctc tttaaaatat ttgtctttaa acagcaacta cagaagtgga 4080 agtgcttgat atgtaagtac ttccacttgt gtatatttta atgaatattg atgttaacaa 4140 gaggggaaaa caaaacacag gttttttcaa tttatgctgc tcatccaaag ttgccacaga 4200 tgatacttcc aagtgataat tttatttata aactaggtaa aatttgttgt tggttccttt 4260 tagaccacgg ctgccccttc cacaccccat cttgctctaa tgatcaaaac atgcttgaat 4320 aactgagctt agagtatacc tcctatatgt ccatttaagt taggagaggg ggcgatatag 4380 agaataaggc acaaaatttt gtttaaaact cagaatataa catgtaaaat cccatctgct 4440 agaagcccat cctgtgccag aggaaggaaa aggaggaaat ttcctttctc ttttaggagg 4500 cacaacagtt ctcttctagg atttgtttgg ctgactggca gtaacctagt gaatttctga 4560 aagatgagta atttctttgg caaccttcct cctcccttac tgaaccactc tcccacctcc 4620 tggtggtacc attattatag aagccctcta cagcctgact ttctctccag cggtccaaag 4680 ttatcccctc ctttacccct catccaaagt tcccactcct tcaggacagc tgctgtgcat 4740 tagatattag gggggaaagt catctgttta atttacacac ttgcatgaat tactgtatat 4800 aaactcctta acttcaggga gctattttca tttagtgcta aacaagtaag aaaaataagc 4860 tcgagtgaat ttctaaatgt tggaatgtta tgggatgtaa acaatgtaaa gtaagacatc 4920 tcaggatttc accagaagtt acagatgagg cactggaagc caccaaatta gcaggtgcac 4980 cttctgtggc tgtcttgttt ctgaagtact taaacttcca caagagtgaa tttgacctag 5040 gcaagtttgt tcaaaaggta gatcctgaga tgatttggtc agattgggat aaggcccagc 5100 aatctgcatt ttaacaagca ccccagtcac taggatgcag atggaccaca ctttgagaaa 5160 caccacccat ttctactttt tgcaccttat tttctctgtt cctgagcccc cacattctct 5220 aggagaaact tagaggaaaa gggcacagac actacatatc taaagctttg gacaagtcct 5280 tgacctctat aaacttcaga gtcctcatta taaaatggga agactgagct ggagttcagc 5340 agtgatgctt ttagttttaa aagtctatga tctggacttc ctataataca aatacacaat 5400 cctccaagaa tttgacttgg aaaaaaatgt caaaggaaaa caggttatct gcccatgtgc 5460 atatggacaa ccttgactac cctggcctgg cccgtggtgg cagtccaggg ctatctgtac 5520 tgtttacaga attactttgt agttgacaac acaaaacaaa caaaaaaggc ataaaatgcc 5580 agcggtttat agaaaaaaca gcatggtatt ctccagttag gtatgccaga gtccaattct 5640 tttaacagct gtgagaattt gctgcttcat tccaacaaaa ttttatttaa aaaaaaaaaa 5700 aaaagactgg agaaactagt cattagcttg ataaagaata tttaacagct agtggtgctg 5760 gtgtgtacct gaagctccag ctacttgaga gactgagaca ggaagatcgc ttgagcccag 5820 gagttcaagt ccagcctaag caacatagca agaccctgtc tcaaaaaaat gactatttaa 5880 aaagacaatg tggccaggca cggtggctca cacctgtaat cccaacactt tgggaggctg 5940 aggccggtgg atcacgaggt caggagtttg agactagcct ggccaacatg gtgaaacccc 6000 atctctaata atataaaaat tagctgggcg tagtagcagg tgcctgtaat cccagttact 6060 cgggaagctg aggcaggaga atcacttgaa cccgggaggc agaggtttca gtgagccgag 6120 atcgcgccac tgcactccag cctgggtgac agggcaagac tctgtctcaa acaaacaaac 6180 aaaaaaaaag ttagtactgt atatgtaaat actagctttt caatgtgcta tacaaacaat 6240 tatagcacat ccttcctttt actctgtctc acctccttta ggtgagtact tccttaaata 6300 agtgctaaac atacatatac ggaacttgaa agctttggtt agccttgcct taggtaatca 6360 gcctagttta cactgtttcc agggagtagt tgaattacta taaaccatta gccacttgtc 6420 tctgcaccat ttatcacacc aggacagggt ctctcaacct gggcgctact gtcatttggg 6480 gccaggtgat tcttccttgc aggggctgtc ctgtaccttg taggacagca gccctgtcct 6540 agaaggtatg tttagcagca ttcctggcct ctagctaccc gatgccagag catgctcccc 6600 ccgcagtcat gacaatcaaa aaatgtctcc agacattgtc aaatgcctcc tggggggcag 6660 tatttctcaa gcacttttaa gcaaaggtaa gtattcatac aagaaattta gggggaaaaa 6720 acattgttta aataaaagct atgtgttcct attcaacaat atttttgctt taaaagtaag 6780 tagagggcat aaaagatgtc atattcaaat ttccatttca taaatggtgt acagacaagg 6840 tctatagaat gtggtaaaaa cttgactgca acacaaggct tataaaatag taagatagta 6900 aaatagctta tgaagaaact acagagattt aaaattgtgc atgactcatt tcagcagcaa 6960 aataagaact cctaactgaa cagaaatttt tctacctagc aatgttattc ttgtaaaata 7020 gttacctatt aaaactgtga agagtaaaac taaagccaat ttattatagt cacacaagtg 7080 attatactaa aaattattat aaaggttata attttataat gtatttacct gtcctgatat 7140 atagctataa cccaatatat gaaaatctca aaaattaaga catcatcata cagaaggcag 7200 gattccttaa actgagatcc ctgatccatc tttaatattt caatttgcac acataaaaca 7260 atgccctttt gtgtacattc aggcataccc attttaatca atttgaaagg ttaatttaaa 7320 cctctagagg tgaatgagaa acatggggga aaagtatgaa ataggtgaaa atcttaacta 7380 tttctttgaa ctctaaagac tgaaactgta gccattatgt aaataaagtt tcatatgtac 7440 ctgtttattt tggcagatta agtcaaaata tgaatgtata tattgcataa ctatgttaga 7500 attgtatata ttttaaagaa attgtcttgg atattttcct ttatacataa tagataagtc 7560 ttttttcaaa tgtggtgttt gatgtttttg attaaatgtg ttttgcctct ttccacaaaa 7620 actgtaaaaa taaatgcatg tttgtacaaa aagttgcaga attcatttga tttatgagaa 7680 acaaaaatta aattgtagtc aacagttagt agtttttctc atatccaagt ataacaaaca 7740 gaaaagtttc attattgtaa cccacttttt tcataccaca ttattgaata ttgttacaat 7800 tgttttgaaa ataaagccat tttctttggg cttttataag tta 7843 <210> 230 <211> 4889 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4889) <223> ITGA3 mRNA <400> 230 agatccgccg cgaagccggg atcgaaggcg acagcgcggc caagggggcg cggccgggac 60 aagctggggg ccggttgccc ggggcaggga cggcggcgac ccggccgctg gggaggcagg 120 aagatagacc cacggatctt aggaagggat ccgagagcgc agctgtgaaa ctggctgggg 180 ctgggggcac gaaaccgatc agcgctacgg agcgcagcgg ccggcgggtt ccagtgtcct 240 ccggcggcgc ggggagcagg tgaacaggtc ctcacgccca gctccgcgcc ctcacgcgct 300 ctcgccggga ccccgcttcc gctggcagcc atgggccccg gccccagccg cgcgccccgc 360 gccccacgcc tgatgctctg tgcgctcgcc ttgatggtgg cggccggcgg ctgcgtcgtc 420 tccgccttca acctggatac ccgattcctg gtagtgaagg aggccgggaa cccgggcagc 480 ctcttcggct actcggtcgc cctccatcgg cagacagagc ggcagcagcg ctacctgctc 540 ctggctggtg ccccccggga gctcgctgtg cccgatggct acaccaaccg gactggtgct 600 gtgtacctgt gcccactcac tgcccacaag gatgactgtg agcggatgaa catcacagtg 660 aaaaatgacc ctggccatca cattattgag gacatgtggc ttggagtgac tgtggccagc 720 cagggccctg caggcagagt tctggtctgt gcccaccgct acacccaggt gctgtggtca 780 gggtcagaag accagcggcg catggtgggc aagtgctacg tgcgaggcaa tgacctagag 840 ctggactcca gtgatgactg gcagacctac cacaacgaga tgtgcaatag caacacagac 900 tacctggaga cgggcatgtg ccagctgggc accagcggtg gcttcaccca gaacactgtg 960 tacttcggcg cccccggtgc ctacaactgg aaaggaaaca gctacatgat tcagcgcaag 1020 gagtgggact tatctgagta tagttacaag gacccagagg accaaggaaa cctctatatt 1080 gggtacacga tgcaggtagg cagcttcatc ctgcacccca aaaacatcac cattgtgaca 1140 ggtgccccac ggcaccgaca tatgggcgcg gtgttcttgc tgagccagga ggcaggcgga 1200 gacctgcgga ggaggcaggt gctggagggc tcgcaggtgg gcgcctattt tggcagcgcc 1260 attgccctgg cagacctgaa caatgatggg tggcaggacc tcctggtggg cgccccctac 1320 tacttcgaga ggaaagagga agtagggggt gccatctatg tcttcatgaa ccaggcggga 1380 acctccttcc ctgctcaccc ctcactcctt cttcatggcc ccagtggctc tgcctttggt 1440 ttatctgtgg ccagcattgg tgacatcaac caggatggat ttcaggatat tgctgtggga 1500 gctccgtttg aaggcttggg caaagtgtac atctatcaca gtagctctaa ggggctcctt 1560 agacagcccc agcaggtaat ccatggagag aagctgggac tgcctgggtt ggccaccttc 1620 ggctattccc tcagtgggca gatggatgtg gatgagaact tctacccaga ccttctagtg 1680 ggaagcctgt cagaccacat tgtgctgctg cgggcccggc ccgtcatcaa catcgtccac 1740 aagaccttgg tgcccaggcc agctgtgctg gaccctgcac tttgcacggc cacctcttgt 1800 gtgcaagtgg agctgtgctt tgcttacaac cagagtgccg ggaaccccaa ctacaggcga 1860 aacatcaccc tggcctacac tctggaggct gacagggacc gccggccgcc ccggctccgc 1920 tttgccggca gtgagtccgc tgtcttccac ggcttcttct ccatgcccga gatgcgctgc 1980 cagaagctgg agctgctcct gatggacaac ctccgtgaca aactccgccc catcatcatc 2040 tccatgaact actctttacc tttgcggatg cccgatcgcc cccggctggg gctgcggtcc 2100 ctggacgcct acccgatcct caaccaggca caggctctgg agaaccacac tgaggtccag 2160 ttccagaagg agtgcgggcc tgacaacaag tgtgagagca acttgcagat gcgggcagcc 2220 ttcgtgtcag agcagcagca gaagctgagc aggctccagt acagcagaga cgtccggaaa 2280 ttgctcctga gcatcaacgt gacgaacacc cggacctcgg agcgctccgg ggaggacgcc 2340 cacgaggcgc tgctcaccct ggtggtgcct cccgccctgc tgctgtcctc agtgcgcccc 2400 cccggggcct gccaagctaa tgagaccatc ttttgcgagc tggggaaccc cttcaaacgg 2460 aaccagagga tggagctgct catcgccttt gaggtcatcg gggtgaccct gcacacaagg 2520 gaccttcagg tgcagctgca gctctccacg tcgagtcacc aggacaacct gtggcccatg 2580 atcctcactc tgctggtgga ctatacactc cagacctcgc ttagcatggt aaatcaccgg 2640 ctacaaagct tctttggggg gacagtgatg ggtgagtctg gcatgaaaac tgtggaggat 2700 gtaggaagcc ccctcaagta tgaattccag gtgggcccaa tgggggaggg gctggtgggc 2760 ctggggaccc tggtcctagg tctggagtgg ccctacgaag tcagcaatgg caagtggctg 2820 ctgtatccca cggagatcac cgtccatggc aatgggtcct ggccctgccg accacctgga 2880 gaccttatca accctctcaa cctcactctt tctgaccctg gggacaggcc atcatcccca 2940 cagcgcaggc ggcgacagct ggatccaggg ggaggccagg gccccccacc tgtcactctg 3000 gctgctgcca aaaaagccaa gtctgagact gtgctgacct gtgccacagg gcgtgcccac 3060 tgtgtgtggc tagagtgccc catccctgat gcccccgttg tcaccaacgt gactgtgaag 3120 gcacgagtgt ggaacagcac cttcatcgag gattacagag actttgaccg agtccgggta 3180 aatggctggg ctaccctatt cctccgaacc agcatcccca ccatcaacat ggagaacaag 3240 accacgtggt tctctgtgga cattgactcg gagctggtgg aggagctgcc ggccgaaatc 3300 gagctgtggc tggtgctggt ggccgtgggt gcagggctgc tgctgctggg gctgatcatc 3360 ctcctgctgt ggaagtgcgg cttcttcaag cgagcccgca ctcgcgccct gtatgaagct 3420 aagaggcaga aggcggagat gaagagccag ccgtcagaga cagagaggct gaccgacgac 3480 tactgagggg gcagcccccc gcccccggcc cacctggtgt gacttcttta agcggacccg 3540 ctattatcag atcatgccca agtaccacgc agtgcggatc cgggaggagg agcgctaccc 3600 acctccaggg agcaccctgc ccaccaagaa gcactgggtg accagctggc agactcggga 3660 ccaatactac tgacgtcctc cctgatccca ccccctcctc ccccagtgtc ccctttcttc 3720 ctatttatca taagttatgc ctctgacagt ccacaggggc caccaccttt ggctggtagc 3780 agcaggctca ggcacataca cctcgtcaag agcatgcaca tgctgtctgg ccctggggat 3840 cttcccacag gagggccagc gctgtggacc ttacaacgcc gagtgcactg cattcctgtg 3900 ccctagatgc acgtggggcc cactgctcgt ggactgtgct ggtgcatcac ggatggtgca 3960 tgggctcgcc gtgtctcagc ctctgccagc gccaaaacaa gccaaagagc ctcccaccag 4020 agccgggagg aaaaggcccc tgcaatgtgg tgacacctcc ccctttcaca ctggatccat 4080 cttgagccac agtcactgga ttgactttgc tgtcaaaact actgacaggg agcagccccc 4140 gggccgctgg ctggtgggcc cccaatgaca cccatgccag agaggtgggg atcctgccta 4200 aggttgtcta cgggggcact tggaggacct ggcgtgctca gacccaacag caaaggaact 4260 agaaagaagg acccagaacg gcttgctttc ctgcatctct gtgaagcctc tctccttggc 4320 cacagactga actcgcaggg aatgcagcag gaaggaacaa agacaggcaa acggcaacgt 4380 agcctgggct cactgtgctg gggcacggcg ggatcctcca cagagaggag gggaccaatt 4440 ctggacagac agatgttggg aggatacaga ggagatgcca cttctcactc accactacca 4500 gccagcctca gaaggcccca gagagaccct gcaagaccac ggagggagcg acacttgaat 4560 gtagaatagg cagggggccc tgccccaccc catccagcca gaccccacgc tgaccatgcg 4620 tcaggggcct agaggtggag ttcttagcta tccttggctt tcagagccag cctggctctg 4680 ccccctcccc catgggctgt gtcctaaggc ccatttgaga agctgaggct agttccagaa 4740 aacctctcct gacccctgcc tgttggcagg cccactcccc agccccagcc ccttccatgg 4800 tactgtagca ggggaattcc ctccccctcc ttgtgccttc tttgtatata ggcttctcac 4860 ggcgaccaat aaacagctcc cagtttgta 4889 <210> 231 <211> 6781 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6781) <223> ITGA4 mRNA <400> 231 gaagcagcgc gagcacccga agctcccggc tggcggcaga aaccgggagt ggggccgggc 60 gagtgcgcgg catcccaggc cggcccgaac gctccgcccg cggtgggccg acttcccctc 120 ctcttccctc tctccttcct ttagcccgct ggcgccggac acgctgcgcc tcatctcttg 180 gggcgttctt ccccgttggc caaccgtcgc atcccgtgca actttggggt agtggccgtt 240 tagtgttgaa tgttccccac cgagagcgca tggcttggga agcgaggcgc gaacccggcc 300 cccgaagggc cgccgtccgg gagacggtga tgctgttgct gtgcctgggg gtcccgaccg 360 gccgccccta caacgtggac actgagagcg cgctgcttta ccagggcccc cacaacacgc 420 tgttcggcta ctcggtcgtg ctgcacagcc acggggcgaa ccgatggctc ctagtgggtg 480 cgcccactgc caactggctc gccaacgctt cagtgatcaa tcccggggcg atttacagat 540 gcaggatcgg aaagaatccc ggccagacgt gcgaacagct ccagctgggt agccctaatg 600 gagaaccttg tggaaagact tgtttggaag agagagacaa tcagtggttg ggggtcacac 660 tttccagaca gccaggagaa aatggatcca tcgtgacttg tgggcataga tggaaaaata 720 tattttacat aaagaatgaa aataagctcc ccactggtgg ttgctatgga gtgccccctg 780 atttacgaac agaactgagt aaaagaatag ctccgtgtta tcaagattat gtgaaaaaat 840 ttggagaaaa ttttgcatca tgtcaagctg gaatatccag tttttacaca aaggatttaa 900 ttgtgatggg ggccccagga tcatcttact ggactggctc tctttttgtc tacaatataa 960 ctacaaataa atacaaggct tttttagaca aacaaaatca agtaaaattt ggaagttatt 1020 taggatattc agtcggagct ggtcattttc ggagccagca tactaccgaa gtagtcggag 1080 gagctcctca acatgagcag attggtaagg catatatatt cagcattgat gaaaaagaac 1140 taaatatctt acatgaaatg aaaggtaaaa agcttggatc gtactttgga gcttctgtct 1200 gtgctgtgga cctcaatgca gatggcttct cagatctgct cgtgggagca cccatgcaga 1260 gcaccatcag agaggaagga agagtgtttg tgtacatcaa ctctggctcg ggagcagtaa 1320 tgaatgcaat ggaaacaaac ctcgttggaa gtgacaaata tgctgcaaga tttggggaat 1380 ctatagttaa tcttggcgac attgacaatg atggctttga agatgttgct atcggagctc 1440 cacaagaaga tgacttgcaa ggtgctattt atatttacaa tggccgtgca gatgggatct 1500 cgtcaacctt ctcacagaga attgaaggac ttcagatcag caaatcgtta agtatgtttg 1560 gacagtctat atcaggacaa attgatgcag ataataatgg ctatgtagat gtagcagttg 1620 gtgcttttcg gtctgattct gctgtcttgc taaggacaag acctgtagta attgttgacg 1680 cttctttaag ccaccctgag tcagtaaata gaacgaaatt tgactgtgtt gaaaatggat 1740 ggccttctgt gtgcatagat ctaacacttt gtttctcata taagggcaag gaagttccag 1800 gttacattgt tttgttttat aacatgagtt tggatgtgaa cagaaaggca gagtctccac 1860 caagattcta tttctcttct aatggaactt ctgacgtgat tacaggaagc atacaggtgt 1920 ccagcagaga agctaactgt agaacacatc aagcatttat gcggaaagat gtgcgggaca 1980 tcctcacccc aattcagatt gaagctgctt accaccttgg tcctcatgtc atcagtaaac 2040 gaagtacaga ggaattccca ccacttcagc caattcttca gcagaagaaa gaaaaagaca 2100 taatgaaaaa aacaataaac tttgcaaggt tttgtgccca tgaaaattgt tctgctgatt 2160 tacaggtttc tgcaaagatt gggtttttga agccccatga aaataaaaca tatcttgctg 2220 ttgggagtat gaagacattg atgttgaatg tgtccttgtt taatgctgga gatgatgcat 2280 atgaaacgac tctacatgtc aaactacccg tgggtcttta tttcattaag attttagagc 2340 tggaagagaa gcaaataaac tgtgaagtca cagataactc tggcgtggta caacttgact 2400 gcagtattgg ctatatatat gtagatcatc tctcaaggat agatattagc tttctcctgg 2460 atgtgagctc actcagcaga gcggaagagg acctcagtat cacagtgcat gctacctgtg 2520 aaaatgaaga ggaaatggac aatctaaagc acagcagagt gactgtagca atacctttaa 2580 aatatgaggt taagctgact gttcatgggt ttgtaaaccc aacttcattt gtgtatggat 2640 caaatgatga aaatgagcct gaaacgtgca tggtggagaa aatgaactta actttccatg 2700 ttatcaacac tggcaatagt atggctccca atgttagtgt ggaaataatg gtaccaaatt 2760 cttttagccc ccaaactgat aagctgttca acattttgga tgtccagact actactggag 2820 aatgccactt tgaaaattat caaagagtgt gtgcattaga gcagcaaaag agtgcaatgc 2880 agaccttgaa aggcatagtc cggttcttgt ccaagactga taagaggcta ttgtactgca 2940 taaaagctga tccacattgt ttaaatttct tgtgtaattt tgggaaaatg gaaagtggaa 3000 aagaagccag tgttcatatc caactggaag gccggccatc cattttagaa atggatgaga 3060 cttcagcact caagtttgaa ataagagcaa caggttttcc agagccaaat ccaagagtaa 3120 ttgaactaaa caaggatgag aatgttgcgc atgttctact ggaaggacta catcatcaaa 3180 gacccaaacg ttatttcacc atagtgatta tttcaagtag cttgctactt ggacttattg 3240 tacttctatt gatctcatat gttatgtgga aggctggctt ctttaaaaga caatacaaat 3300 ctatcctaca agaagaaaac agaagagaca gttggagtta tatcaacagt aaaagcaatg 3360 atgattaagg acttctttca aattgagaga atggaaaaca gactcaggtt gtagtaaaga 3420 aatttaaaag acactgttta caagaaaaaa tgaattttgt ttggacttct tttactcatg 3480 atcttgtgac atattatgtc ttcatgcaag gggaaaatct cagcaatgat tactctttga 3540 gatagaagaa ctgcaaaggt aataatacag ccaaagataa tctctcagct tttaaatggg 3600 tagagaaaca ctaaagcatt caatttattc aagaaaagta agcccttgaa gatatcttga 3660 aatgaaagta taactgagtt aaattatact ggagaagtct tagacttgaa atactactta 3720 ccatatgtgc ttgcctcagt aaaatgaacc ccactgggtg ggcagaggtt catttcaaat 3780 acatctttga tacttgttca aaatatgttc tttaaaaata taatttttta gagagctgtt 3840 cccaaatttt ctaacgagtg gaccattatc actttaaagc cctttattta taatacattt 3900 cctacgggct gtgttccaac aaccattttt tttcagcaga ctatgaatat tatagtatta 3960 taggccaaac tggcaaactt cagactgaac atgtacactg gtttgagctt agtgaaatta 4020 cttctggata attatttttt tataattatg gatttcacca tctttctttc tgtatatata 4080 catgtgtttt tatgtaggta tatatttacc attcttccta tctattcttc ctataacaca 4140 cctttatcaa gcatacccag gagtaatctt caaatctttt gttatattct gaaacaaaag 4200 attgtgagtg ttgcacttta cctgatacac gctgatttag aaaatacaga aaccatacct 4260 cactaataac tttaaaatca aagctgtgca aagactaggg ggcctatact tcatatgtat 4320 tatgtactat gtaaaatatt gactatcaca caactatttc cttggatgta attctttgtt 4380 accctttaca agtataagtg ttaccttaca tggaaacgaa gaaacaaaat tcataaattt 4440 aaattcataa atttagctga aagatactga ttcaatttgt atacagtgaa tataaatgag 4500 acgacagcaa aattttcatg aaatgtaaaa tatttttata gtttgttcat actatatgag 4560 gttctatttt aaatgacttt ctggatttta aaaaatttct ttaaatacaa tcatttttgt 4620 aatatttatt ttatgcttat gatctagata attgcagaat atcattttat ctgactctgc 4680 cttcataaga gagctgtggc cgaattttga acatctgtta tagggagtga tcaaattaga 4740 aggcaatgtg gaaaaacaat tctgggaaag atttctttat atgaagtccc tgccactagc 4800 cagccatcct aattgatgaa agttatctgt tcacaggcct gcagtgatgg tgaggaatgt 4860 tctgagattt gcgaaggcat ttgagtagtg aaatgtaagc acaaaacctc ctgaacccag 4920 agtgtgtata cacaggaata aactttatga catttatgta tttttaaaaa actttgtatc 4980 gttataaaaa ggctagtcat tctttcagga gaacatctag gatcatagat gaaaaatcaa 5040 gccccgattt agaactgtct tctccaggat ggtctctaag gaaatttaca tttggttctt 5100 tcctactcag aactactcag aaacaactat atatttcagg ttatctgagc acagtgaaag 5160 cagagtacta tggttgtcca acacaggcct ctcagataca aggggaacac aattacatat 5220 tgggctagat tttgcccagt tcaaaatagt atttgttatc aacttacttt gttacttgta 5280 tcatgaattt taaaacccta ccactttaag aagacaggga tgggttattc ttttttggca 5340 ggtaggctat ataactatgt gattttgaaa tttaactgct ctggattagg gagcagtgaa 5400 tcaaggcaga cttatgaaat ctgtattata tttgtaacag aatataggaa atttaacata 5460 attgatgagc tcaaatcctg aaaaatgaaa gaatccaaat tatttcagaa ttatctaggt 5520 taaatattga tgtattatga tggttgcaaa gtttttttgt gtgtccaata aacacattgt 5580 aaaaaaaaga atttgaattg atatctaaaa acagaatttg aattgatatt tcatcttgac 5640 ttttaaagcc ctagaggcta attgttagta acatcaattt ctattaggat atccgtttgg 5700 ccacacagca ggaggttaga gcaatggagc attactgagt tcctccccct gtcagatcag 5760 cagcagcatt agattctcat agaagtgcga accatatggt gaactggtat gtgagggatc 5820 tagagtgcca tgttcctcaa gagaatctaa tgcctgatga tctgaggtgg aacagttcat 5880 cctgaaacca ttcccccatc cacggaaaaa ttgtcttcca tgaaactggt cccaaaaagg 5940 gtggggacca caggtttaaa gcatggccac atttctttat attaaaattc tagtttgtac 6000 atttctttta gaaacaatta catgttactt tggaatcatt tcttccatgc ttcctccata 6060 aagactgata agtcttggat gcaatctgta aagaaaatac attatttcat caacttattt 6120 tgttgttttt cacatacacc taataagtat ggtacacaat gccaatgcca aatacaaatt 6180 gataacaaac acagcattcc caacagagct gtaatctaga aaactgagaa ggtctgattg 6240 ataaatcatc aacaacaata attgctctaa aacctcctta actgacttcc ttgattgtcc 6300 aatgctctcc attacctctg taaaacagtc agttatgcct ctagaacacc catgtctagt 6360 gggcacccct gcatgcttct tctaaccact gagtgtcaca atgcctacca agaatgcgtt 6420 tgcaggttcc taaacctgtt tataccagtt gctatgtaaa attgttccca agggaagttg 6480 aatgctctgt aaaggcctaa taaaagcaaa ttactgaaca aaacatgtta cagtaattat 6540 gagtgagagg aaactaagat ggaaggataa aaatctaaca ctttactatt cagatggctc 6600 cactaaaaga tttaagatct tgatccattt ttaaaaatcc aaaatggaag ttgtagacat 6660 tatctgtagt ttatgcacaa caataaatta gaaagccaat gtagacacgc ataaccaaag 6720 aaaatgcctt gggtctacat aacagttgaa taaatgtaaa gttgcttttt atttattgaa 6780 a 6781 <210> 232 <211> 4267 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4267) <223> ITGA5 mRNA <400> 232 attcgcctct gggaggttta ggaagcggct ccgggtcggt ggccccagga cagggaagag 60 cgggcgctat ggggagccgg acgccagagt cccctctcca cgccgtgcag ctgcgctggg 120 gcccccggcg ccgacccccg ctgctgccgc tgctgttgct gctgctgccg ccgccaccca 180 gggtcggggg cttcaactta gacgcggagg ccccagcagt actctcgggg cccccgggct 240 ccttcttcgg attctcagtg gagttttacc ggccgggaac agacggggtc agtgtgctgg 300 tgggagcacc caaggctaat accagccagc caggagtgct gcagggtggt gctgtctacc 360 tctgtccttg gggtgccagc cccacacagt gcacccccat tgaatttgac agcaaaggct 420 ctcggctcct ggagtcctca ctgtccagct cagagggaga ggagcctgtg gagtacaagt 480 ccttgcagtg gttcggggca acagttcgag cccatggctc ctccatcttg gcatgcgctc 540 cactgtacag ctggcgcaca gagaaggagc cactgagcga ccccgtgggc acctgctacc 600 tctccacaga taacttcacc cgaattctgg agtatgcacc ctgccgctca gatttcagct 660 gggcagcagg acagggttac tgccaaggag gcttcagtgc cgagttcacc aagactggcc 720 gtgtggtttt aggtggacca ggaagctatt tctggcaagg ccagatcctg tctgccactc 780 aggagcagat tgcagaatct tattaccccg agtacctgat caacctggtt caggggcagc 840 tgcagactcg ccaggccagt tccatctatg atgacagcta cctaggatac tctgtggctg 900 ttggtgaatt cagtggtgat gacacagaag actttgttgc tggtgtgccc aaagggaacc 960 tcacttacgg ctatgtcacc atccttaatg gctcagacat tcgatccctc tacaacttct 1020 caggggaaca gatggcctcc tactttggct atgcagtggc cgccacagac gtcaatgggg 1080 acgggctgga tgacttgctg gtgggggcac ccctgctcat ggatcggacc cctgacgggc 1140 ggcctcagga ggtgggcagg gtctacgtct acctgcagca cccagccggc atagagccca 1200 cgcccaccct taccctcact ggccatgatg agtttggccg atttggcagc tccttgaccc 1260 ccctggggga cctggaccag gatggctaca atgatgtggc catcggggct ccctttggtg 1320 gggagaccca gcagggagta gtgtttgtat ttcctggggg cccaggaggg ctgggctcta 1380 agccttccca ggttctgcag cccctgtggg cagccagcca caccccagac ttctttggct 1440 ctgcccttcg aggaggccga gacctggatg gcaatggata tcctgatctg attgtggggt 1500 cctttggtgt ggacaaggct gtggtataca ggggccgccc catcgtgtcc gctagtgcct 1560 ccctcaccat cttccccgcc atgttcaacc cagaggagcg gagctgcagc ttagagggga 1620 accctgtggc ctgcatcaac cttagcttct gcctcaatgc ttctggaaaa cacgttgctg 1680 actccattgg tttcacagtg gaacttcagc tggactggca gaagcagaag ggaggggtac 1740 ggcgggcact gttcctggcc tccaggcagg caaccctgac ccagaccctg ctcatccaga 1800 atggggctcg agaggattgc agagagatga agatctacct caggaacgag tcagaatttc 1860 gagacaaact ctcgccgatt cacatcgctc tcaacttctc cttggacccc caagccccag 1920 tggacagcca cggcctcagg ccagccctac attatcagag caagagccgg atagaggaca 1980 aggctcagat cttgctggac tgtggagaag acaacatctg tgtgcctgac ctgcagctgg 2040 aagtgtttgg ggagcagaac catgtgtacc tgggtgacaa gaatgccctg aacctcactt 2100 tccatgccca gaatgtgggt gagggtggcg cctatgaggc tgagcttcgg gtcaccgccc 2160 ctccagaggc tgagtactca ggactcgtca gacacccagg gaacttctcc agcctgagct 2220 gtgactactt tgccgtgaac cagagccgcc tgctggtgtg tgacctgggc aaccccatga 2280 aggcaggagc cagtctgtgg ggtggccttc ggtttacagt ccctcatctc cgggacacta 2340 agaaaaccat ccagtttgac ttccagatcc tcagcaagaa tctcaacaac tcgcaaagcg 2400 acgtggtttc ctttcggctc tccgtggagg ctcaggccca ggtcaccctg aacggtgtct 2460 ccaagcctga ggcagtgcta ttcccagtaa gcgactggca tccccgagac cagcctcaga 2520 aggaggagga cctgggacct gctgtccacc atgtctatga gctcatcaac caaggcccca 2580 gctccattag ccagggtgtg ctggaactca gctgtcccca ggctctggaa ggtcagcagc 2640 tcctatatgt gaccagagtt acgggactca actgcaccac caatcacccc attaacccaa 2700 agggcctgga gttggatccc gagggttccc tgcaccacca gcaaaaacgg gaagctccaa 2760 gccgcagctc tgcttcctcg ggacctcaga tcctgaaatg cccggaggct gagtgtttca 2820 ggctgcgctg tgagctcggg cccctgcacc aacaagagag ccaaagtctg cagttgcatt 2880 tccgagtctg ggccaagact ttcttgcagc gggagcacca gccatttagc ctgcagtgtg 2940 aggctgtgta caaagccctg aagatgccct accgaatcct gcctcggcag ctgccccaaa 3000 aagagcgtca ggtggccaca gctgtgcaat ggaccaaggc agaaggcagc tatggcgtcc 3060 cactgtggat catcatccta gccatcctgt ttggcctcct gctcctaggt ctactcatct 3120 acatcctcta caagcttgga ttcttcaaac gctccctccc atatggcacc gccatggaaa 3180 aagctcagct caagcctcca gccacctctg atgcctgagt cctcccaatt tcagactccc 3240 attcctgaag aaccagtccc cccaccctca ttctactgaa aaggaggggt ctgggtactt 3300 cttgaaggtg ctgacggcca gggagaagct cctctcccca gcccagagac atacttgaag 3360 ggccagagcc aggggggtga ggagctgggg atccctcccc cccatgcact gtgaaggacc 3420 cttgtttaca cataccctct tcatggatgg gggaactcag atccagggac agaggcccca 3480 gcctccctga agcctttgca ttttggagag tttcctgaaa caacttggaa agataactag 3540 gaaatccatt cacagttctt tgggccagac atgccacaag gacttcctgt ccagctccaa 3600 cctgcaaaga tctgtcctca gccttgccag agatccaaaa gaagccccca gctaagaacc 3660 tggaacttgg ggagttaaga cctggcagct ctggacagcc ccaccctggt gggccaacaa 3720 agaacactaa ctatgcatgg tgccccagga ccagctcagg acagatgcca cacaaggata 3780 gatgctggcc cagggcccag agcccagctc caaggggaat cagaactcaa atggggccag 3840 atccagcctg gggtctggag ttgatctgga acccagactc agacattggc acctaatcca 3900 ggcagatcca ggactatatt tgggcctgct ccagacctga tcctggaggc ccagttcacc 3960 ctgatttagg agaagccagg aatttcccag gaccctgaag gggccatgat ggcaacagat 4020 ctggaacctc agcctggcca gacacaggcc ctccctgttc cccagagaaa ggggagccca 4080 ctgtcctggg cctgcagaat ttgggttctg cctgccagct gcactgatgc tgcccctcat 4140 ctctctgccc aacccttccc tcaccttggc accagacacc caggacttat ttaaactctg 4200 ttgcaagtgc aataaatctg acccagtgcc cccactgacc agaactagaa aaaaaaaaaa 4260 aaaaaaa 4267 <210> 233 <211> 7039 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(7039) <223> ITGAV mRNA <400> 233 agtccccagc ctcagacgct gcgtggagcg gcggagccgg agggaagcaa aggaccgtct 60 gcgctgctgt ccccgccccg cgcgctctgc gcccctcgtc cctggcggtc gctccgaagc 120 tcagccctct tgcctgcccc ggagctgtcc cgggctagcc gagaagagag cggccggcaa 180 gtttgggcgc gcgcaggcgg cgggccgcgg gcactgggcg cctcgctggg gcggggggag 240 gtggctaccg ctcccggctt ggcgtcccgc gcgcacttcg gcgatggctt ttccgccgcg 300 gcgacggctg cgcctcggtc cccgcggcct cccgcttctt ctctcgggac tcctgctacc 360 tctgtgccgc gccttcaacc tagacgtgga cagtcctgcc gagtactctg gccccgaggg 420 aagttacttc ggcttcgccg tggatttctt cgtgcccagc gcgtcttccc ggatgtttct 480 tctcgtggga gctcccaaag caaacaccac ccagcctggg attgtggaag gagggcaggt 540 cctcaaatgt gactggtctt ctacccgccg gtgccagcca attgaatttg atgcaacagg 600 caatagagat tatgccaagg atgatccatt ggaatttaag tcccatcagt ggtttggagc 660 atctgtgagg tcgaaacagg ataaaatttt ggcctgtgcc ccattgtacc attggagaac 720 tgagatgaaa caggagcgag agcctgttgg aacatgcttt cttcaagatg gaacaaagac 780 tgttgagtat gctccatgta gatcacaaga tattgatgct gatggacagg gattttgtca 840 aggaggattc agcattgatt ttactaaagc tgacagagta cttcttggtg gtcctggtag 900 cttttattgg caaggtcagc ttatttcgga tcaagtggca gaaatcgtat ctaaatacga 960 ccccaatgtt tacagcatca agtataataa ccaattagca actcggactg cacaagctat 1020 ttttgatgac agctatttgg gttattctgt ggctgtcgga gatttcaatg gtgatggcat 1080 agatgacttt gtttcaggag ttccaagagc agcaaggact ttgggaatgg tttatattta 1140 tgatgggaag aacatgtcct ccttatacaa ttttactggc gagcagatgg ctgcatattt 1200 cggattttct gtagctgcca ctgacattaa tggagatgat tatgcagatg tgtttattgg 1260 agcacctctc ttcatggatc gtggctctga tggcaaactc caagaggtgg ggcaggtctc 1320 agtgtctcta cagagagctt caggagactt ccagacgaca aagctgaatg gatttgaggt 1380 ctttgcacgg tttggcagtg ccatagctcc tttgggagat ctggaccagg atggtttcaa 1440 tgatattgca attgctgctc catatggggg tgaagataaa aaaggaattg tttatatctt 1500 caatggaaga tcaacaggct tgaacgcagt cccatctcaa atccttgaag ggcagtgggc 1560 tgctcgaagc atgccaccaa gctttggcta ttcaatgaaa ggagccacag atatagacaa 1620 aaatggatat ccagacttaa ttgtaggagc ttttggtgta gatcgagcta tcttatacag 1680 ggccagacca gttatcactg taaatgctgg tcttgaagtg taccctagca ttttaaatca 1740 agacaataaa acctgctcac tgcctggaac agctctcaaa gtttcctgtt ttaatgttag 1800 gttctgctta aaggcagatg gcaaaggagt acttcccagg aaacttaatt tccaggtgga 1860 acttcttttg gataaactca agcaaaaggg agcaattcga cgagcactgt ttctctacag 1920 caggtcccca agtcactcca agaacatgac tatttcaagg gggggactga tgcagtgtga 1980 ggaattgata gcgtatctgc gggatgaatc tgaatttaga gacaaactca ctccaattac 2040 tatttttatg gaatatcggt tggattatag aacagctgct gatacaacag gcttgcaacc 2100 cattcttaac cagttcacgc ctgctaacat tagtcgacag gctcacattc tacttgactg 2160 tggtgaagac aatgtctgta aacccaagct ggaagtttct gtagatagtg atcaaaagaa 2220 gatctatatt ggggatgaca accctctgac attgattgtt aaggctcaga atcaaggaga 2280 aggtgcctac gaagctgagc tcatcgtttc cattccactg caggctgatt tcatcggggt 2340 tgtccgaaac aatgaagcct tagcaagact ttcctgtgca tttaagacag aaaaccaaac 2400 tcgccaggtg gtatgtgacc ttggaaaccc aatgaaggct ggaactcaac tcttagctgg 2460 tcttcgtttc agtgtgcacc agcagtcaga gatggatact tctgtgaaat ttgacttaca 2520 aatccaaagc tcaaatctat ttgacaaagt aagcccagtt gtatctcaca aagttgatct 2580 tgctgtttta gctgcagttg agataagagg agtctcgagt cctgatcatg tctttcttcc 2640 gattccaaac tgggagcaca aggagaaccc tgagactgaa gaagatgttg ggccagttgt 2700 tcagcacatc tatgagctga gaaacaatgg tccaagttca ttcagcaagg caatgctcca 2760 tcttcagtgg ccttacaaat ataataataa cactctgttg tatatccttc attatgatat 2820 tgatggacca atgaactgca cttcagatat ggagatcaac cctttgagaa ttaagatctc 2880 atctttgcaa acaactgaaa agaatgacac ggttgccggg caaggtgagc gggaccatct 2940 catcactaag cgggatcttg ccctcagtga aggagatatt cacactttgg gttgtggagt 3000 tgctcagtgc ttgaagattg tctgccaagt tgggagatta gacagaggaa agagtgcaat 3060 cttgtacgta aagtcattac tgtggactga gacttttatg aataaagaaa atcagaatca 3120 ttcctattct ctgaagtcgt ctgcttcatt taatgtcata gagtttcctt ataagaatct 3180 tccaattgag gatatcacca actccacatt ggttaccact aatgtcacct ggggcattca 3240 gccagcgccc atgcctgtgc ctgtgtgggt gatcatttta gcagttctag caggattgtt 3300 gctactggct gttttggtat ttgtaatgta caggatgggc ttttttaaac gggtccggcc 3360 acctcaagaa gaacaagaaa gggagcagct tcaacctcat gaaaatggtg aaggaaactc 3420 agaaacttaa ctgcagtttt taagttatgc tacatcttga cccactagaa ttagcaactt 3480 tattatagat ttaaactttc ttcatgagga gtaaaaatcc aaggctttac tgctgatagt 3540 gctaattggc attaaccaca aaatgagaat tatatttgtc aaccttctcc ttataaataa 3600 gttcagacat acatttaata acatagggtg acttgtgttt ttaggtattt aaataataaa 3660 atttcaaggg atagttttta ttcaatgtat ataagacagg tagtgcctga tttactactt 3720 tatataaaat agtacctcct tcagttactg tttctgattt aatgtacgga actttatttg 3780 ttgttgttgt tgttgttgtt gttgttgttt taaagcagtc caaatttgga ccttagcaat 3840 catgtctttt gtataggtac ttaatgttaa tacatattac actacagttt acttttcaga 3900 atactaaaga ctttataact gcatgaactt ggattttttt aatcactcat atggtagaat 3960 tttataaaca catacatgat accatccaaa ttcttgcttt taataacaaa ggtacaatat 4020 tttgttttag tatgaaaatc tggtagatcc tattacactt ctgtttatat taaatccaca 4080 atattttatt acatttttaa cttgtataaa ttttaggtca aatccttcaa gccaacctat 4140 actaaaaatt agttccataa tcacaaatgg ctcttttgtg taattgttta atttcacctg 4200 aatatcataa tgcttaaagc catatggagt tggaaattat ttccaaagca tatttattcc 4260 attgttttag tctggctatt tacagtataa aaaaagcatt tttattaaaa tactgtgtag 4320 ttctttgaga tagttgctta tgcatatagt aagtattaca ttcttagagt agagcagagt 4380 ttttagttag tattaattta ttttcctcca ttcatgtact tttccttata tttccaaaac 4440 tgttactgag aatgggtcaa gatcagtgag aaatctttac agttgacagg aacctggacc 4500 ccttacccca actttatgag taatgcttgg aataaaaact cttaaggcaa ctcactgatt 4560 tacttctagc aatagcatga tgttacagga atattacctc tgtttaagca aggtaatgtg 4620 taaaatcagt ctcggctgtc agaataactt ctaaaaggta tttttataag cagttcaagt 4680 tactgaaaac cttttaaacc tttctgaagt tcgttagtat aaattacttt tctaggatta 4740 ttaataaaag ccacataggt ggcaagttgt agttttatat ggctctgtag agtggtgaac 4800 cttctagagg aatatatgat ttattcacag ttcctcaagg cctggggatg atgatcagtt 4860 atacctattt ttgtgcaatt acatcatgtt gtacattaga aatggagagt ttaatagctc 4920 tttaactgct gtcctcatta ggtaatgata aatatttccc ttaaataatt gactattttg 4980 ctgtgtttta aaaatgattg aaatttatct tgccatatct cataatttca tgcacaagtt 5040 gactgagcta atcttgagaa tatattcgta aaataggagc acatttagtt gaggtataca 5100 aggtaggact ctagacaaaa ccttctattt tagctttagt gaatttcaaa agtaatgggt 5160 cttggagtat agatttttat tagtagcttg aaagagctta atcatatgca gtaagtattt 5220 ttattaccaa taaatttaaa attttttaag aaaaatattt ttatcctagg gccaagtgtt 5280 gcctgccacc aatcagtaag ttagtctata acaaatttta ccctaacagt tttaccacct 5340 agtaacagtc atttctgaaa atatgttgga tagaaagtca ctctttggca aaagtgttag 5400 aatttgcttt tgtgccatct attcctttta tggcatctat cttgaaagta atcttgtatt 5460 ggagattgaa agatgctgta atttagaaat taacatgata tcttaaatta cctttatgaa 5520 atatagtttt gtataatagc atagattttc cttcaaaaaa tgaacattta tatatctaca 5580 aaaatatgga gaagagtaat ttgaaagcct actttctgaa gaaaatggtg ggattttttt 5640 ttatcatgat taaatatcaa aaaattgccc tatgaaaact ttaaatctct aaaacatttg 5700 aaatactacc atatttgtga tttattgaga ataaaaatcc attttgaaat gtaaaatttt 5760 tatgatctga ttcagtttta agaaaacatg aatgaactag aagatattaa aaacatttga 5820 cattggtaag aaatattgat actgatattg atttttatat aggtatttat ttcagaattg 5880 atattttgag aaaaatacat gtgagtcatt ttttctgttt ctcttttctc ttaacgatta 5940 tcactgtaat tctgaatctg aaaggtaaaa caattagtca aaatattatt gccatcattc 6000 tacctgtgtt atgaaactac ttattcatag ttaattctca ttaacactta catttccata 6060 aagaaaactc aagtattaat aaaagagact ttactggctt aagagggctg tgaaagattt 6120 ttgatagtga atcatgaccc taagggagag atttgtgtga taaaagtatt gtatataata 6180 gatcagcgat ttttgtaagg caaacagaat ttgtaagttg gcagatcttc ctaagttgca 6240 aaatgtaatg atgagcttgg tggagaagaa tgagtcgttc ttggaatacc tatgtgcagc 6300 cactacccat ctcaatgtca ccttgtttgc attcttggat agcttgtata tgtagtagtt 6360 tgatgaataa tttaaagaaa aacacctaaa atttgaaaaa tgattgtagg atcaaaaaag 6420 gcagatgaaa ttacttaata ctcagtgttt tggagagtat tccttttagt ttgttggttg 6480 gctggtttga acgatagaaa tatgcagcat gcaatatatg cttatatttc attttaattt 6540 ctgatatata atgaacttct tgggagaggt actgaatctt tgatgttttt tgtcattgtt 6600 ctcaagtgca atataacaat gtaaccaaat ctagataatt tcaaagttgt cattaattta 6660 gtaagcctaa tataaacaaa tatttgtatt atttttgtta gcaggaaaga gtgattaagt 6720 gaggttattt acccctaaat ggtccattct gcattgtatt tcaggctgga aatgaattat 6780 tctttaccag ttttgaaaca ctttgaaata tcctaaggta acttggaagc tgtgtagtat 6840 atcaaattaa tttgctacct aataacatag aaagtaaata tctttgtggt cacccacatt 6900 gggtgagaca gaaaatgaat ctgttctaaa atttgtaatt tgctaacttg atttgagtta 6960 gtgaaaactg gtacagtgtt ctgcttgatt tacaacatgt aacttgtgac tgtacaataa 7020 acataagcat atggtacca 7039 <210> 234 <211> 3739 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3739) <223> ITGB1 mRNA <400> 234 atgaatttac aaccaatttt ctggattgga ctgatcagtt cagtttgctg tgtgtttgct 60 caaacagatg aaaatagatg tttaaaagca aatgccaaat catgtggaga atgtatacaa 120 gcagggccaa attgtgggtg gtgcacaaat tcaacatttt tacaggaagg aatgcctact 180 tctgcacgat gtgatgattt agaagcctta aaaaagaagg gttgccctcc agatgacata 240 gaaaatccca gaggctccaa agatataaag aaaaataaaa atgtaaccaa ccgtagcaaa 300 ggaacagcag agaagctcaa gccagaggat attactcaga tccaaccaca gcagttggtt 360 ttgcgattaa gatcagggga gccacagaca tttacattaa aattcaagag agctgaagac 420 tatcccattg acctctacta ccttatggac ctgtcttact caatgaaaga cgatttggag 480 aatgtaaaaa gtcttggaac agatctgatg aatgaaatga ggaggattac ttcggacttc 540 agaattggat ttggctcatt tgtggaaaag actgtgatgc cttacattag cacaacacca 600 gctaagctca ggaacccttg cacaagtgaa cagaactgca ccagcccatt tagctacaaa 660 aatgtgctca gtcttactaa taaaggagaa gtatttaatg aacttgttgg aaaacagcgc 720 atatctggaa atttggattc tccagaaggt ggtttcgatg ccatcatgca agttgcagtt 780 tgtggatcac tgattggctg gaggaatgtt acacggctgc tggtgttttc cacagatgcc 840 gggtttcact ttgctggaga tgggaaactt ggtggcattg ttttaccaaa tgatggacaa 900 tgtcacctgg aaaataatat gtacacaatg agccattatt atgattatcc ttctattgct 960 caccttgtcc agaaactgag tgaaaataat attcagacaa tttttgcagt tactgaagaa 1020 tttcagcctg tttacaagga gctgaaaaac ttgatcccta agtcagcagt aggaacatta 1080 tctgcaaatt ctagcaatgt aattcagttg atcattgatg catacaattc cctttcctca 1140 gaagtcattt tggaaaacgg caaattgtca gaaggcgtaa caataagtta caaatcttac 1200 tgcaagaacg gggtgaatgg aacaggggaa aatggaagaa aatgttccaa tatttccatt 1260 ggagatgagg ttcaatttga aattagcata acttcaaata agtgtccaaa aaaggattct 1320 gacagcttta aaattaggcc tctgggcttt acggaggaag tagaggttat tcttcagtac 1380 atctgtgaat gtgaatgcca aagcgaaggc atccctgaaa gtcccaagtg tcatgaagga 1440 aatgggacat ttgagtgtgg cgcgtgcagg tgcaatgaag ggcgtgttgg tagacattgt 1500 gaatgcagca cagatgaagt taacagtgaa gacatggatg cttactgcag gaaagaaaac 1560 agttcagaaa tctgcagtaa caatggagag tgcgtctgcg gacagtgtgt ttgtaggaag 1620 agggataata caaatgaaat ttattctggc aaattctgcg agtgtgataa tttcaactgt 1680 gatagatcca atggcttaat ttgtggagga aatggtgttt gcaagtgtcg tgtgtgtgag 1740 tgcaacccca actacactgg cagtgcatgt gactgttctt tggatactag tacttgtgaa 1800 gccagcaacg gacagatctg caatggccgg ggcatctgcg agtgtggtgt ctgtaagtgt 1860 acagatccga agtttcaagg gcaaacgtgt gagatgtgtc agacctgcct tggtgtctgt 1920 gctgagcata aagaatgtgt tcagtgcaga gccttcaata aaggagaaaa gaaagacaca 1980 tgcacacagg aatgttccta ttttaacatt accaaggtag aaagtcggga caaattaccc 2040 cagccggtcc aacctgatcc tgtgtcccat tgtaaggaga aggatgttga cgactgttgg 2100 ttctatttta cgtattcagt gaatgggaac aacgaggtca tggttcatgt tgtggagaat 2160 ccagagtgtc ccactggtcc agacatcatt ccaattgtag ctggtgtggt tgctggaatt 2220 gttcttattg gccttgcatt actgctgata tggaagcttt taatgataat tcatgacaga 2280 agggagtttg ctaaatttga aaaggagaaa atgaatgcca aatgggacac gcaagaaaat 2340 ccgatttaca agagtcctat taataatttc aagaatccaa actacggacg taaagctggt 2400 ctctaaattg ccggtgaaaa tcctatttat aagagtgccg taacaactgt ggtcaatccg 2460 aagtatgagg gaaaatgagt actgcccgtg caaatcccac aacactgaat gcaaagtagc 2520 aatttccata gtcacagtta ggtagcttta gggcaatatt gccatggttt tactcatgtg 2580 caggttttga aaatgtacaa tatgtataat ttttaaaatg ttttattatt ttgaaaataa 2640 tgttgtaatt catgccaggg actgacaaaa gacttgagac aggatggtta ctcttgtcag 2700 ctaaggtcac attgtgcctt tttgaccttt tcttcctgga ctattgaaat caagcttatt 2760 ggattaagtg atatttctat agcgattgaa agggcaatag ttaaagtaat gagcatgatg 2820 agagtttctg ttaatcatgt attaaaactg atttttagct ttacaaatat gtcagtttgc 2880 agttatgcag aatccaaagt aaatgtcctg ctagctagtt aaggattgtt ttaaatctgt 2940 tattttgcta tttgcctgtt agacatgact gatgacatat ctgaaagaca agtatgttga 3000 gagttgctgg tgtaaaatac gtttgaaata gttgatctac aaaggccatg ggaaaaattc 3060 agagagttag gaaggaaaaa ccaatagctt taaaacctgt gtgccatttt aagagttact 3120 taatgtttgg taacttttat gccttcactt tacaaattca agccttagat aaaagaaccg 3180 agcaattttc tgctaaaaag tccttgattt agcactattt acatacaggc catactttac 3240 aaagtatttg ctgaatgggg accttttgag ttgaatttat tttattattt ttattttgtt 3300 taatgtctgg tgctttctgt cacctcttct aatcttttaa tgtatttgtt tgcaattttg 3360 gggtaagact ttttttatga gtactttttc tttgaagttt tagcggtcaa tttgcctttt 3420 taatgaacat gtgaagttat actgtggcta tgcaacagct ctcacctacg cgagtcttac 3480 tttgagttag tgccataaca gaccactgta tgtttacttc tcaccatttg agttgcccat 3540 cttgtttcac actagtcaca ttcttgtttt aagtgccttt agttttaaca gttcactttt 3600 tacagtgcta tttactgaag ttatttatta aatatgccta aaatacttaa atcggatgtc 3660 ttgactctga tgtattttat caggttgtgt gcatgaaatt tttatagatt aaagaagttg 3720 aggaaaagca aaaaaaaaa 3739 <210> 235 <211> 4894 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4894) <223> ITGB3 mRNA <400> 235 cgccgcggga ggcggacgag atgcgagcgc ggccgcggcc ccggccgctc tgggcgactg 60 tgctggcgct gggggcgctg gcgggcgttg gcgtaggagg gcccaacatc tgtaccacgc 120 gaggtgtgag ctcctgccag cagtgcctgg ctgtgagccc catgtgtgcc tggtgctctg 180 atgaggccct gcctctgggc tcacctcgct gtgacctgaa ggagaatctg ctgaaggata 240 actgtgcccc agaatccatc gagttcccag tgagtgaggc ccgagtacta gaggacaggc 300 ccctcagcga caagggctct ggagacagct cccaggtcac tcaagtcagt ccccagagga 360 ttgcactccg gctccggcca gatgattcga agaatttctc catccaagtg cggcaggtgg 420 aggattaccc tgtggacatc tactacttga tggacctgtc ttactccatg aaggatgatc 480 tgtggagcat ccagaacctg ggtaccaagc tggccaccca gatgcgaaag ctcaccagta 540 acctgcggat tggcttcggg gcatttgtgg acaagcctgt gtcaccatac atgtatatct 600 ccccaccaga ggccctcgaa aacccctgct atgatatgaa gaccacctgc ttgcccatgt 660 ttggctacaa acacgtgctg acgctaactg accaggtgac ccgcttcaat gaggaagtga 720 agaagcagag tgtgtcacgg aaccgagatg ccccagaggg tggctttgat gccatcatgc 780 aggctacagt ctgtgatgaa aagattggct ggaggaatga tgcatcccac ttgctggtgt 840 ttaccactga tgccaagact catatagcat tggacggaag gctggcaggc attgtccagc 900 ctaatgacgg gcagtgtcat gttggtagtg acaatcatta ctctgcctcc actaccatgg 960 attatccctc tttggggctg atgactgaga agctatccca gaaaaacatc aatttgatct 1020 ttgcagtgac tgaaaatgta gtcaatctct atcagaacta tagtgagctc atcccaggga 1080 ccacagttgg ggttctgtcc atggattcca gcaatgtcct ccagctcatt gttgatgctt 1140 atgggaaaat ccgttctaaa gtagagctgg aagtgcgtga cctccctgaa gagttgtctc 1200 tatccttcaa tgccacctgc ctcaacaatg aggtcatccc tggcctcaag tcttgtatgg 1260 gactcaagat tggagacacg gtgagcttca gcattgaggc caaggtgcga ggctgtcccc 1320 aggagaagga gaagtccttt accataaagc ccgtgggctt caaggacagc ctgatcgtcc 1380 aggtcacctt tgattgtgac tgtgcctgcc aggcccaagc tgaacctaat agccatcgct 1440 gcaacaatgg caatgggacc tttgagtgtg gggtatgccg ttgtgggcct ggctggctgg 1500 gatcccagtg tgagtgctca gaggaggact atcgcccttc ccagcaggac gaatgcagcc 1560 cccgggaggg tcagcccgtc tgcagccagc ggggcgagtg cctctgtggt caatgtgtct 1620 gccacagcag tgactttggc aagatcacgg gcaagtactg cgagtgtgac gacttctcct 1680 gtgtccgcta caagggggag atgtgctcag gccatggcca gtgcagctgt ggggactgcc 1740 tgtgtgactc cgactggacc ggctactact gcaactgtac cacgcgtact gacacctgca 1800 tgtccagcaa tgggctgctg tgcagcggcc gcggcaagtg tgaatgtggc agctgtgtct 1860 gtatccagcc gggctcctat ggggacacct gtgagaagtg ccccacctgc ccagatgcct 1920 gcacctttaa gaaagaatgt gtggagtgta agaagtttga ccggggagcc ctacatgacg 1980 aaaatacctg caaccgttac tgccgtgacg agattgagtc agtgaaagag cttaaggaca 2040 ctggcaagga tgcagtgaat tgtacctata agaatgagga tgactgtgtc gtcagattcc 2100 agtactatga agattctagt ggaaagtcca tcctgtatgt ggtagaagag ccagagtgtc 2160 ccaagggccc tgacatcctg gtggtcctgc tctcagtgat gggggccatt ctgctcattg 2220 gccttgccgc cctgctcatc tggaaactcc tcatcaccat ccacgaccga aaagaattcg 2280 ctaaatttga ggaagaacgc gccagagcaa aatgggacac agccaacaac ccactgtata 2340 aagaggccac gtctaccttc accaatatca cgtaccgggg cacttaatga taagcagtca 2400 tcctcagatc attatcagcc tgtgccacga ttgcaggagt ccctgccatc atgtttacag 2460 aggacagtat ttgtggggag ggatttgggg ctcagagtgg ggtaggttgg gagaatgtca 2520 gtatgtggaa gtgtgggtct gtgtgtgtgt atgtgggggt ctgtgtgttt atgtgtgtgt 2580 gttgtgtgtg ggagtgtgta atttaaaatt gtgatgtgtc ctgataagct gagctcctta 2640 gcctttgtcc cagaatgcct cctgcaggga ttcttcctgc ttagcttgag ggtgactatg 2700 gagctgagca ggtgttcttc attacctcag tgagaagcca gctttcctca tcaggccatt 2760 gtccctgaag agaagggcag ggctgaggcc tctcattcca gaggaaggga caccaagcct 2820 tggctctacc ctgagttcat aaatttatgg ttctcaggcc tgactctcag cagctatggt 2880 aggaactgct gggcttggca gcccgggtca tctgtacctc tgcctccttt cccctccctc 2940 aggccgaagg aggagtcagg gagagctgaa ctattagagc tgcctgtgcc ttttgccatc 3000 ccctcaaccc agctatggtt ctctcgcaag ggaagtcctt gcaagctaat tctttgacct 3060 gttgggagtg aggatgtctg ggccactcag gggtcattca tggcctgggg gatgtaccag 3120 catctcccag ttcataatca caacccttca gatttgcctt attggcagct ctactctgga 3180 ggtttgttta gaagaagtgt gtcaccctta ggccagcacc atctctttac ctcctaattc 3240 cacaccctca ctgctgtaga catttgctat gagctgggga tgtctctcat gaccaaatgc 3300 ttttcctcaa agggagagag tgctattgta gagccagagg tctggcccta tgcttccggc 3360 ctcctgtccc tcatccatag cacctccaca tacctggccc tgtgccttgg tgtgctgtat 3420 ccatccatgg ggctgattgt atttaccttc tacctcttgg ctgccttgtg aaggaattat 3480 tcccatgagt tggctgggaa taagtgccag gatggaatga tgggtcagtt gtatcagcac 3540 gtgtggcctg ttcttctatg ggttggacaa cctcatttta actcagtctt taatctgaga 3600 ggccacagtg caattttatt ttatttttct catgatgagg ttttcttaac ttaaaagaac 3660 atgtatataa acatgcttgc attatatttg taaatttatg tgatggcaaa gaaggagagc 3720 ataggaaacc acacagactt gggcagggta cagacactcc cacttggcat cattcacagc 3780 aagtcactgg ccagtggctg gatctgtgag gggctctctc atgatagaag gctatgggga 3840 tagatgtgtg gacacattgg acctttcctg aggaagaggg actgttcttt tgtcccagaa 3900 aagcagtggc tccattggtg ttgacataca tccaacatta aaagccaccc ccaaatgccc 3960 aagaaaaaaa gaaagactta tcaacatttg ttccatgagc agaaaactgg agctctggcc 4020 tcagtgttac agctaaataa tctttaatta aggcaagtca ctttcttctt cttaaagctg 4080 ttttctagtt tgagaaatga tgggatttta gcagccagtc ttgaaggtct ctttcagtat 4140 caacattcta agatgctggg acttactgtg tcatcaaatg tgcggttaag attctctggg 4200 atattgatac tgtttgtgtt tttagttggg agatctgaga gacctggctt tggcaagagc 4260 agatgtcatt ccatatcacc tttctcaatg aaagtctcat tctatcctct ctccaaaccc 4320 gttttccaac atttgttaat agttacgtct ctcctgatgt agcacttaag cttcatttag 4380 ttattatttc tttcttcact ttgcacacat ttgcatccac atattaggga agaggaatcc 4440 ataagtagct gaaatatcta ttctgtatta ttgtgttaac attgagaata agccttggaa 4500 ttagatatgg ggcaatgact gagccctgtc tcacccatgg attactcctt actgtaggga 4560 atggcagtat ggtagaggga taaatagggg gcggggaggg atagtcatgg atccaagaag 4620 tccttagaaa tagtggcagg gaacaggtgt ggaagctcat gcctgtaatt ataaccttca 4680 gctactaaga caggtgtggt ggctcacgcc tgtgattata atcttcagtt actaagacag 4740 agtccatgag agtgttaatg ggacattttc tttagataag atgttttata tgaagaaact 4800 gtatcaaagg gggaagaaaa tgtatttaac aggtgaatca aatcaggaat cttgtctgag 4860 ctactggaat gaagttcaca ggtcttgaag acca 4894 <210> 236 <211> 4392 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4392) <223> ITGB5 mRNA <400> 236 gccgccgagc ggagccagcc cctcccctac ccggagcagc ccgctggggc cgtcccgagc 60 ggcgacacac taggagtccc ggccggccag ccagggcagc cgcggtcccg ggactcggcc 120 gtgagtgctg cgggacggat ggtggcggcg gggcgcgggc cagcgcgggc gccgtgagcc 180 ggagctgcgc gcggggcatg cggctgcggc ccccggccct cggcccccgc gctccggccc 240 cagccccggc cgccggcccc cgcggagtgc agcgaccgcg ccgccgctga gggaggcgcc 300 ccaccatgcc gcgggccccg gcgccgctgt acgcctgcct cctggggctc tgcgcgctcc 360 tgccccggct cgcaggtctc aacatatgca ctagtggaag tgccacctca tgtgaagaat 420 gtctgctaat ccacccaaaa tgtgcctggt gctccaaaga ggacttcgga agcccacggt 480 ccatcacctc tcggtgtgat ctgagggcaa accttgtcaa aaatggctgt ggaggtgaga 540 tagagagccc agccagcagc ttccatgtcc tgaggagcct gcccctcagc agcaagggtt 600 cgggctctgc aggctgggac gtcattcaga tgacaccaca ggagattgcc gtgaacctcc 660 ggcccggtga caagaccacc ttccagctac aggttcgcca ggtggaggac tatcctgtgg 720 acctgtacta cctgatggac ctctccctgt ccatgaagga tgacttggac aatatccgga 780 gcctgggcac caaactcgcg gaggagatga ggaagctcac cagcaacttc cggttgggat 840 ttgggtcttt tgttgataag gacatctctc ctttctccta cacggcaccg aggtaccaga 900 ccaatccgtg cattggttac aagttgtttc caaattgcgt cccctccttt gggttccgcc 960 atctgctgcc tctcacagac agagtggaca gcttcaatga ggaagttcgg aaacagaggg 1020 tgtcccggaa ccgagatgcc cctgaggggg gctttgatgc agtactccag gcagccgtct 1080 gcaaggagaa gattggctgg cgaaaggatg cactgcattt gctggtgttc acaacagatg 1140 atgtgcccca catcgcattg gatggaaaat tgggaggcct ggtgcagcca cacgatggcc 1200 agtgccacct gaacgaggcc aacgagtaca ctgcatccaa ccagatggac tatccatccc 1260 ttgccttgct tggagagaaa ttggcagaga acaacatcaa cctcatcttt gcagtgacaa 1320 aaaaccatta tatgctgtac aagaatttta cagccctgat acctggaaca acggtggaga 1380 ttttagatgg agactccaaa aatattattc aactgattat taatgcatac aatagtatcc 1440 ggtctaaagt ggagttgtca gtctgggatc agcctgagga tcttaatctc ttctttactg 1500 ctacctgcca agatggggta tcctatcctg gtcagaggaa gtgtgagggt ctgaagattg 1560 gggacacggc atcttttgaa gtatcattgg aggcccgaag ctgtcccagc agacacacgg 1620 agcatgtgtt tgccctgcgg ccggtgggat tccgggacag cctggaggtg ggggtcacct 1680 acaactgcac gtgcggctgc agcgtggggc tggaacccaa cagcgccagg tgcaacggga 1740 gcgggaccta tgtctgcggc ctgtgtgagt gcagccccgg ctacctgggc accaggtgcg 1800 agtgccagga tggggagaac cagagcgtgt accagaacct gtgccgggag gcagagggca 1860 agccactgtg cagcgggcgt ggggactgca gctgcaacca gtgctcctgc ttcgagagcg 1920 agtttggcaa gatctatggg cctttctgtg agtgcgacaa cttctcctgt gccaggaaca 1980 agggagtcct ctgctcaggc catggcgagt gtcactgcgg ggaatgcaag tgccatgcag 2040 gttacatcgg ggacaactgt aactgctcga cagacatcag cacatgccgg ggcagagatg 2100 gccagatctg cagcgagcgt gggcactgtc tctgtgggca gtgccaatgc acggagccgg 2160 gggcctttgg ggagatgtgt gagaagtgcc ccacctgccc ggatgcatgc agcaccaaga 2220 gagattgcgt cgagtgcctg ctgctccact ctgggaaacc tgacaaccag acctgccaca 2280 gcctatgcag ggatgaggtg atcacatggg tggacaccat cgtgaaagat gaccaggagg 2340 ctgtgctatg tttctacaaa accgccaagg actgcgtcat gatgttcacc tatgtggagc 2400 tccccagtgg gaagtccaac ctgaccgtcc tcagggagcc agagtgtgga aacaccccca 2460 acgccatgac catcctcctg gctgtggtcg gtagcatcct ccttgttggg cttgcactcc 2520 tggctatctg gaagctgctt gtcaccatcc acgaccggag ggagtttgca aagtttcaga 2580 gcgagcgatc cagggcccgc tatgaaatgg cttcaaatcc attatacaga aagcctatct 2640 ccacgcacac tgtggacttc accttcaaca agttcaacaa atcctacaat ggcactgtgg 2700 actgatgttt ccttctccga ggggctggag cggggatctg atgaaaaggt cagactgaaa 2760 cgccttgcac ggctgctcgg cttgatcaca gctccctagg taggcaccac agagaagacc 2820 ttctagtgag cctgggccag gagcccacag tgcctgtaca ggaaggtgcc tggccatgtc 2880 acctggctgc taggccagag ccatgccagg ctgcgtccct ccgagcttgg gataaagcaa 2940 ggggaccttg gcgctctcag ctttccctgc cacatccagc ttgttgtccc aatgaaatac 3000 tgagatgctg ggctgtctct cccttccagg aatgctgggc ccccagcctg gccagacaag 3060 aagactgtca ggaagggtcg gagtctgtaa aaccagcata cagtttggct tttttcacat 3120 tgatcatttt tatatgaaat aaaaagatcc tgcatttatg gtgtagttct gagtcctgag 3180 acttttctgc gtgatggcta tgccttgcac acaggtgttg gtgatggggc tgttgagatg 3240 cctgttgaag gtacatcgtt tgcaaatgtc agtttcctct cctgtccgtg tttgtttagt 3300 acttttataa tgaaaagaaa caagattgtt tgggattgga agtaaagatt aaaaccaaaa 3360 gaatttgtgt ttgtctgata ctctctgtgt gtttctttct ttctgagcgg acttaaaatg 3420 gtgcccccag tggggattga agcggccgtg tacttcctca gggatgggac acaggctggt 3480 ctgatactcc agactgcagc ttgtcaagta agcatgaggt gctcggggca gtgagggctg 3540 tgcaaggggg aacactgagc agataccttt ggccccttcc agcttttact gacagagagt 3600 tccaggctag acaccataaa aaccacccct tgttctgagg ggctgaggct ggaaatagat 3660 tgtacagaca agcaagggtt gagtggtggt tcccacacga agtcatctct taatcatcat 3720 tagcaatagc agttcccttc caaggcctcc cctcactccc gaaacactta cgtcccatgc 3780 aggcccaatg caaaaaaaca catttgagct tttttcccgc agggccatga agtcccctta 3840 agttcccata tctaagatgg ttgactgacc ctctcccctt atgtacagaa gaggaaactg 3900 attctcagag aggggaagtg gcttgcccga gtgtttgtta ggaggttact gaatgacaaa 3960 ctgttcctaa gaccccatct catgctggcc agagggccag cctcctcatt cctgcttgct 4020 cttagaaaat ctttcactga tcattttttg tcactggaat aacttcaagg ttattatgct 4080 ttcattccaa atggatctgt cctcagctct ggacccaatt ccccttactt cattttggca 4140 aacactaagt caaatagtga aatgcctgtc actacataga acctattacc tggggcaaat 4200 acgaacagat tgagtttcct tcatcttgtg taaatatgat gaaacagaga cctggtaact 4260 tggtgacact gttaaaccct ttttgggata aagccaaatg taaatgaaaa cattaaacag 4320 ataaattgtg gtgttgagac ttttctgaat tgagaaaaat aaatgtaatt ttggaagaaa 4380 aaaaaaaaaa aa 4392 <210> 237 <211> 1183 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1183) <223> KRTAP1-5 mRNA <400> 237 aaacctcaga aactcctcca agcaacctaa ctcttaaccc aacttctgac accatgacct 60 gctgccagac cagcttctgt ggatatccca gcttctccat cagtgggacc tgtggctcca 120 gctgctgcca gccaagctgc tgtgagacca gctgctgcca gccacgcagc tgccagacta 180 gcttctgcgg atttcccagc ttctcaacca gtgggacctg cagctccagt tgctgccagc 240 caagctgctg tgagaccagc tgctgccagc caagctgctg tgagaccagc tgctgccagc 300 caagctgctg ccagatcagc tcctgcggaa ctggctgtgg cattggtggt ggcatcagct 360 atggccagga gggcagcagt ggagctgtga gcacccgtat caggtggtgc cgcccagaca 420 gtcgtgtgga gggcacctac ctacccccct gctgtgtggt gagctgcacg cccccatcct 480 gctgccaact gcaccatgcc caggcctcct gctgccgccc gtcctactgt ggacagtcct 540 gctgccgccc agtctgctgc tgtgagccca cttgctgaaa gccagtttgc ttattttcaa 600 ttgcctaggt cacagtgtct ctgaactgtt catcccttga ccacctctgg accactaaca 660 agttctcaga ctttgcattg cttgtgatgg agactactaa gtatatgagc tcacaattct 720 atctgattcc attctacaat gaataccttg acccttcact ggggacacag aaatgctaca 780 aagccacctg ctgatcatca atttgcttgg gatatactat ttctgatatt tctgcaggat 840 taaaaattac tgacatgttg tggaatttat ccatgagaac tatccacaag tctaatgttt 900 ccatgcttta taatctattt tatcttgttt acctaaaatt ttttgcaaca tcaaagacac 960 caaattatag ccaagtgaca ttcctcaagt caccagagag aatggaagct catcacccaa 1020 cattcagctt ctaagaagta ggctggactt tccacatttt aacatctgat ccatcccttg 1080 gtttttggat cataatgatc ttgcctgctg gatatttcag ttatatctgt gatacaatgt 1140 cttctgtcat ttcttaataa atattatata ctaggcaaag aaa 1183 <210> 238 <211> 1965 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1965) <223> LPXN mRNA <400> 238 aggtcgcgac gcgtgccgta catccgggct caagcgtcga gccaattgct ggtctgatgg 60 gagggttttt cctacttttt cttacttttt atctgggcgt tggcgtacct ttctcggggt 120 gtctgcgtaa ctgcccagac ttgccttggt ttggtcagat gacacctcct ctgggactgg 180 ctagccagcg ttcatgtcta cattattgat ctcgtcttcc gatgccttat tggaggaact 240 ggaacgctcc acccttcagg acagtgatga atattccaac ccagctcctc ttcccctgga 300 tcagcattcc agaaaggaga ctaaccttga tgagacttcg gagatccttt ctattcagga 360 taacacaagt cccttgccgg cgcagctcgt gtatactacc aatatccagg agctcaatgt 420 ctacagtgaa gcccaagagc caaaggaatc accaccacct tctaaaacgt cagcagctgc 480 tcagttggat gagctcatgg ctcacctgac tgagatgcag gccaaggttg cagtgagagc 540 agatgctggc aagaagcact taccagacaa gcaggatcac aaggcctccc tggactcaat 600 gcttgggggt ctggagcagg aattgcagga ccttggcatt gccacagtgc ccaagggcca 660 ttgtgcatcc tgccagaaac cgattgctgg gaaggtgatc catgctctag ggcaatcatg 720 gcatcctgag cattttgtct gtactcattg caaagaagag attggctcca gtcccttctt 780 tgagcggagt ggcttggcct actgccccaa cgactaccac caactttttt ctccacgctg 840 tgcttactgc gctgctccca tcctggataa agtgctgaca gcaatgaacc agacctggca 900 cccagagcac ttcttctgct ctcactgcgg agaggtgttt ggtgcagaag gctttcatga 960 gaaggacaag aagccatatt gccgaaagga tttcttagcc atgttctcac ccaagtgtgg 1020 tggctgcaat cgcccagtgt tggaaaacta cctttcagcc atggacactg tctggcaccc 1080 agagtgcttt gtttgtgggg actgcttcac cagtttttct actggctcct tctttgaact 1140 ggatggacgt ccattctgtg agctccatta ccatcaccgc cggggaacgc tctgccatgg 1200 gtgtgggcag cccatcactg gccgttgtat cagtgccatg gggtacaagt tccatcctga 1260 gcactttgtg tgtgctttct gcctgacaca gttgtcgaag ggcattttca gggagcagaa 1320 tgacaagacc tattgtcaac cttgcttcaa taagctcttc ccactgtaat gccaactgat 1380 ccatagcctc ttcagattcc ttataaaatt taaaccaaga gaggagagga aagggtaaat 1440 tttctgttac tgaccttctg cttaatagtc ttatagaaaa aggaaaggtg atgagcaaat 1500 aaaggaactt ctagacttta catgactagg ctgataatct tattttttag gcttctatac 1560 agttaattct ataaattctc tttctccctc tcttctccaa tcaagcactt ggagttagat 1620 ctaggtcctt ctatctcgtc cctctacaga tgtattttcc acttgcataa ttcatgccaa 1680 cactggtttt cttaggtttc tccattttca cctctagtga tggccctact catatcttct 1740 ctaatttggt cctgatactt gtttcttttc acgttttccc atttccctgt ggctcactgt 1800 cttacaatca ctgctgtgga atcatgatac cacttttagc tctttgcatc ttccttcagt 1860 gtatttttgt ttttcaagag gaagtagatt ttaactggac aactttgagt actgacatca 1920 ttgataaata aactggcttg tggtttcaat aaaaaaaaaa aaaaa 1965 <210> 239 <211> 1514 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1514) <223> MAPK1 mRNA <400> 239 gcccctccct ccgcccgccc gccggcccgc ccgtcagtct ggcaggcagg caggcaatcg 60 gtccgagtgg ctgtcggctc ttcagctctc ccgctcggcg tcttccttcc tcctcccggt 120 cagcgtcggc ggctgcaccg gcggcggcgc agtccctgcg ggaggggcga caagagctga 180 gcggcggccg ccgagcgtcg agctcagcgc ggcggaggcg gcggcggccc ggcagccaac 240 atggcggcgg cggcggcggc gggcgcgggc ccggagatgg tccgcgggca ggtgttcgac 300 gtggggccgc gctacaccaa cctctcgtac atcggcgagg gcgcctacgg catggtgtgc 360 tctgcttatg ataatgtcaa caaagttcga gtagctatca agaaaatcag cccctttgag 420 caccagacct actgccagag aaccctgagg gagataaaaa tcttactgcg cttcagacat 480 gagaacatca ttggaatcaa tgacattatt cgagcaccaa ccatcgagca aatgaaagat 540 gtatatatag tacaggacct catggaaaca gatctttaca agctcttgaa gacacaacac 600 ctcagcaatg accatatctg ctattttctc taccagatcc tcagagggtt aaaatatatc 660 cattcagcta acgttctgca ccgtgacctc aagccttcca acctgctgct caacaccacc 720 tgtgatctca agatctgtga ctttggcctg gcccgtgttg cagatccaga ccatgatcac 780 acagggttcc tgacagaata tgtggccaca cgttggtaca gggctccaga aattatgttg 840 aattccaagg gctacaccaa gtccattgat atttggtctg taggctgcat tctggcagaa 900 atgctttcta acaggcccat ctttccaggg aagcattatc ttgaccagct gaaccacatt 960 ttgggtattc ttggatcccc atcacaagaa gacctgaatt gtataataaa tttaaaagct 1020 aggaactatt tgctttctct tccacacaaa aataaggtgc catggaacag gctgttccca 1080 aatgctgact ccaaagctct ggacttattg gacaaaatgt tgacattcaa cccacacaag 1140 aggattgaag tagaacaggc tctggcccac ccatatctgg agcagtatta cgacccgagt 1200 gacgagccca tcgccgaagc accattcaag ttcgacatgg aattggatga cttgcctaag 1260 gaaaagctca aagaactaat ttttgaagag actgctagat tccagccagg atacagatct 1320 taaatttgtc aggtacctgg agtttaatac agtgagctct agcaagggag gcgctgcctt 1380 ttgtttctag aatattatgt tcctcaaggt ccattatttt gtattctttt ccaagctcct 1440 tattggaagg tattttttta aatttagaat taaaaattat ttagaaagtt acatataaaa 1500 aaaaaaaaaa aaaa 1514 <210> 240 <211> 1174 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1174) <223> MAPK3 mRNA <400> 240 ctggcgcgcg cggccctgcg ggtgacaggc aggcgggaag gggcggggcc tcgggcgggg 60 ccgccgtggg gaggagggcg gtgggagggg aggagtggag atggcggcgg cggcggctca 120 ggggggcggg ggcggggagc cccgtagaac cgagggggtc ggcccggggg tcccggggga 180 ggtggagatg gtgaaggggc agccgttcga cgtgggcccg cgctacacgc agttgcagta 240 catcggcgag ggcgcgtacg gcatggtcag ctcggcctat gaccacgtgc gcaagactcg 300 cgtggccatc aagaagatca gccccttcga acatcagacc tactgccagc gcacgctccg 360 ggagatccag atcctgctgc gcttccgcca tgagaatgtc atcggcatcc gagacattct 420 gcgggcgtcc accctggaag ccatgagaga tgtctacatt gtgcaggacc tgatggagac 480 tgacctgtac aagttgctga aaagccagca gctgagcaat gaccatatct gctacttcct 540 ctaccagatc ctgcggggcc tcaagtacat ccactccgcc aacgtgctcc accgagatct 600 aaagccctcc aacctgctca tcaacaccac ctgcgacctt aagatttgtg atttcggcct 660 ggcccggatt gccgatcctg agcatgacca caccggcttc ctgacggagt atgtggctac 720 gcgctggtac cgggccccag agatcatgct gaactccaag ggctatacca agtccatcga 780 catctggtct gtgggctgca ttctggctga gatgctctct aaccggccca tcttccctgg 840 caagcactac ctggatcagc tcaaccacat tctgggcatc ctgggctccc catcccagga 900 ggacctgaat tgtatcatca acatgaaggc ccgaaactac ctacagtctc tgccctccaa 960 gaccaaggtg gcttgggcca agcttttccc caagtcagac tccaaagccc ttgacctgct 1020 ggaccggatg ttaaccttta accccaataa acggatcaca gtggaggaag cgctggctca 1080 cccctacctg gagcagtact atgacccgac ggatgaggtg ggccagtccc cagcagcagt 1140 ggggctgggg gcaggggagc aggggggcac gtag 1174 <210> 241 <211> 3950 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3950) <223> MCL1 mRNA <400> 241 acttctcact tccgcttcct tccagtaagg agtcggggtc ttccccagtt ttctcagcca 60 ggcggcggcg gcgactggca atgtttggcc tcaaaagaaa cgcggtaatc ggactcaacc 120 tctactgtgg gggggccggc ttgggggccg gcagcggcgg cgccacccgc ccgggagggc 180 gacttttggc tacggagaag gaggcctcgg cccggcgaga gataggggga ggggaggccg 240 gcgcggtgat tggcggaagc gccggcgcaa gccccccgtc caccctcacg ccagactccc 300 ggagggtcgc gcggccgccg cccattggcg ccgaggtccc cgacgtcacc gcgacccccg 360 cgaggctgct tttcttcgcg cccacccgcc gcgcggcgcc gcttgaggag atggaagccc 420 cggccgctga cgccatcatg tcgcccgaag aggagctgga cgggtacgag ccggagcctc 480 tcgggaagcg gccggctgtc ctgccgctgc tggagttggt cggggaatct ggtaataaca 540 ccagtacgga cgggtcacta ccctcgacgc cgccgccagc agaggaggag gaggacgagt 600 tgtaccggca gtcgctggag attatctctc ggtaccttcg ggagcaggcc accggcgcca 660 aggacacaaa gccaatgggc aggtctgggg ccaccagcag gaaggcgctg gagaccttac 720 gacgggttgg ggatggcgtg cagcgcaacc acgagacggc cttccaaggc atgcttcgga 780 aactggacat caaaaacgaa gacgatgtga aatcgttgtc tcgagtgatg atccatgttt 840 tcagcgacgg cgtaacaaac tggggcagga ttgtgactct catttctttt ggtgcctttg 900 tggctaaaca cttgaagacc ataaaccaag aaagctgcat cgaaccatta gcagaaagta 960 tcacagacgt tctcgtaagg acaaaacggg actggctagt taaacaaaga ggctgggatg 1020 ggtttgtgga gttcttccat gtagaggacc tagaaggtgg catcaggaat gtgctgctgg 1080 cttttgcagg tgttgctgga gtaggagctg gtttggcata tctaataaga tagccttact 1140 gtaagtgcaa tagttgactt ttaaccaacc accaccacca ccaaaaccag tttatgcagt 1200 tggactccaa gctgtaactt cctagagttg caccctagca acctagccag aaaagcaagt 1260 ggcaagagga ttatggctaa caagaataaa tacatgggaa gagtgctccc cattgattga 1320 agagtcactg tctgaaagaa gcaaagttca gtttcagcaa caaacaaact ttgtttggga 1380 agctatggag gaggactttt agatttagtg aagatggtag ggtggaaaga cttaatttcc 1440 ttgttgagaa caggaaagtg gccagtagcc aggcaagtca tagaattgat tacccgccga 1500 attcattaat ttactgtagt gttaagagaa gcactaagaa tgccagtgac ctgtgtaaaa 1560 gttacaagta atagaactat gactgtaagc ctcagtactg tacaagggaa gcttttcctc 1620 tctctaatta gctttcccag tatacttctt agaaagtcca agtgttcagg acttttatac 1680 ctgttatact ttggcttggt ttccatgatt cttactttat tagcctagtt tatcaccaat 1740 aatacttgac ggaaggctca gtaattagtt atgaatatgg atatcctcaa ttcttaagac 1800 agcttgtaaa tgtatttgta aaaattgtat atatttttac agaaagtcta tttctttgaa 1860 acgaaggaag tatcgaattt acattagttt ttttcatacc cttttgaact ttgcaacttc 1920 cgtaattagg aacctgtttc ttacagcttt tctatgctaa actttgttct gttcagttct 1980 agagtgtata cagaacgaat tgatgtgtaa ctgtatgcag actggttgta gtggaacaaa 2040 tctgataact atgcaggttt aaattttctt atctgatttt ggtaagtatt ccttaggttt 2100 ttctttgaaa acctgggatt gagaggttga tgaatggaaa ttctttcact tcattatatg 2160 caagttttca ataattaggt ctaagtggag ttttaaggtt actgatgact tacaaataat 2220 gggctctgat tgggcaatac tcatttgagt tccttccatt tgacctaatt taactggtga 2280 aatttaaagt gaattcatgg gctcatcttt aaagctttta ctaaaagatt ttcagctgaa 2340 tggaactcat tagctgtgtg catataaaaa gatcacatca ggtggatgga gagacatttg 2400 atcccttgtt tgcttaataa attataaaat gatggcttgg aaaagcaggc tagtctaacc 2460 atggtgctat tattaggctt gcttgttaca cacacaggtc taagcctagt atgtcaataa 2520 agcaaatact tactgttttg tttctattaa tgattcccaa accttgttgc aagtttttgc 2580 attggcatct ttggatttca gtcttgatgt ttgttctatc agacttaacc ttttatttcc 2640 tgtccttcct tgaaattgct gattgttctg ctccctctac agatatttat atcaattcct 2700 acagctttcc cctgccatcc ctgaactctt tctagccctt ttagattttg gcactgtgaa 2760 acccctgctg gaaacctgag tgaccctccc tccccaccaa gagtccacag acctttcatc 2820 tttcacgaac ttgatcctgt tagcaggtgg taataccatg ggtgctgtga cactaacagt 2880 cattgagagg tgggaggaag tcccttttcc ttggactggt atcttttcaa ctattgtttt 2940 atcctgtctt tgggggcaat gtgtcaaaag tcccctcagg aattttcaga ggaaagaaca 3000 ttttatgagg ctttctctaa agtttccttt gtataggagt atgctcactt aaatttacag 3060 aaagaggtga gctgtgttaa acctcagagt ttaaaagcta ctgataaact gaagaaagtg 3120 tctatattgg aactagggtc atttgaaagc ttcagtctcg gaacatgacc tttagtctgt 3180 ggactccatt taaaaatagg tatgaataag atgactaaga atgtaatggg gaagaactgc 3240 cctgcctgcc catctcagag ccataaggtc atctttgcta gagctatttt tacctatgta 3300 tttatcgttc ttgatcataa gccgcttatt tatatcatgt atctctaagg acctaaaagc 3360 actttatgta gtttttaatt aatcttaaga tctggttacg gtaactaaaa aagcctgtct 3420 gccaaatcca gtggaaacaa gtgcatagat gtgaattggt ttttaggggc cccacttccc 3480 aattcattag gtatgactgt ggaaatacag acaaggatct tagttgatat tttgggcttg 3540 gggcagtgag ggcttaggac accccaagtg gtttgggaaa ggaggagggg agtggtgggt 3600 ttataggggg aggaggaggc aggtggtcta agtgctgact ggctacgtag ttcgggcaaa 3660 tcctccaaaa gggaaaggga ggatttgctt agaaggatgg cgctcccagt gactactttt 3720 tgacttctgt ttgtcttacg cttctctcag ggaaaaacat gcagtcctct agtgtttcat 3780 gtacattctg tggggggtga acaccttggt tctggttaaa cagctgtact tttgatagct 3840 gtgccaggaa gggttaggac caactacaaa ttaatgttgg ttgtcaaatg tagtgtgttt 3900 ccctaacttt ctgtttttcc tgagaaaaaa aaataaatct tttattcaaa 3950 <210> 242 <211> 561 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(561) <223> MIF mRNA <400> 242 accacagtgg tgtccgagaa gtcaggcacg tagctcagcg gcggccgcgg cgcgtgcgtc 60 tgtgcctctg cgcgggtctc ctggtccttc tgccatcatg ccgatgttca tcgtaaacac 120 caacgtgccc cgcgcctccg tgccggacgg gttcctctcc gagctcaccc agcagctggc 180 gcaggccacc ggcaagcccc cccagtacat cgcggtgcac gtggtcccgg accagctcat 240 ggccttcggc ggctccagcg agccgtgcgc gctctgcagc ctgcacagca tcggcaagat 300 cggcggcgcg cagaaccgct cctacagcaa gctgctgtgc ggcctgctgg ccgagcgcct 360 gcgcatcagc ccggacaggg tctacatcaa ctattacgac atgaacgcgg ccaatgtggg 420 ctggaacaac tccaccttcg cctaagagcc gcagggaccc acgctgtctg cgctggctcc 480 acccgggaac ccgccgcacg ctgtgttcta ggcccgccca ccccaacctt ctggtgggga 540 gaaataaacg gtttagagac t 561 <210> 243 <211> 1971 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1971) <223> MMP1 mRNA <400> 243 atattggagc agcaagaggc tgggaagcca tcacttacct tgcactgaga aagaagacaa 60 aggccagtat gcacagcttt cctccactgc tgctgctgct gttctggggt gtggtgtctc 120 acagcttccc agcgactcta gaaacacaag agcaagatgt ggacttagtc cagaaatacc 180 tggaaaaata ctacaacctg aagaatgatg ggaggcaagt tgaaaagcgg agaaatagtg 240 gcccagtggt tgaaaaattg aagcaaatgc aggaattctt tgggctgaaa gtgactggga 300 aaccagatgc tgaaaccctg aaggtgatga agcagcccag atgtggagtg cctgatgtgg 360 ctcagtttgt cctcactgag gggaaccctc gctgggagca aacacatctg acctacagga 420 ttgaaaatta cacgccagat ttgccaagag cagatgtgga ccatgccatt gagaaagcct 480 tccaactctg gagtaatgtc acacctctga cattcaccaa ggtctctgag ggtcaagcag 540 acatcatgat atcttttgtc aggggagatc atcgggacaa ctctcctttt gatggacctg 600 gaggaaatct tgctcatgct tttcaaccag gcccaggtat tggaggggat gctcattttg 660 atgaagatga aaggtggacc aacaatttca gagagtacaa cttacatcgt gttgcagctc 720 atgaactcgg ccattctctt ggactctccc attctactga tatcggggct ttgatgtacc 780 ctagctacac cttcagtggt gatgttcagc tagctcagga tgacattgat ggcatccaag 840 ccatatatgg acgttcccaa aatcctgtcc agcccatcgg cccacaaacc ccaaaagcgt 900 gtgacagtaa gctaaccttt gatgctataa ctacgattcg gggagaagtg atgttcttta 960 aagacagatt ctacatgcgc acaaatccct tctacccgga agttgagctc aatttcattt 1020 ctgttttctg gccacaactg ccaaatgggc ttgaagctgc ttacgaattt gccgacagag 1080 atgaagtccg gtttttcaaa gggaataagt actgggctgt tcagggacag aatgtgctac 1140 acggataccc caaggacatc tacagctcct ttggcttccc tagaactgtg aagcatatcg 1200 atgctgctct ttctgaggaa aacactggaa aaacctactt ctttgttgct aacaaatact 1260 ggaggtatga tgaatataaa cgatctatgg atccaggtta tcccaaaatg atagcacatg 1320 actttcctgg aattggccac aaagttgatg cagttttcat gaaagatgga tttttctatt 1380 tctttcatgg aacaagacaa tacaaatttg atcctaaaac gaagagaatt ttgactctcc 1440 agaaagctaa tagctggttc aactgcagga aaaattgaac attactaatt tgaatggaaa 1500 acacatggtg tgagtccaaa gaaggtgttt tcctgaagaa ctgtctattt tctcagtcat 1560 ttttaacctc tagagtcact gatacacaga atataatctt atttatacct cagtttgcat 1620 atttttttac tatttagaat gtagcccttt ttgtactgat ataatttagt tccacaaatg 1680 gtgggtacaa aaagtcaagt ttgtggctta tggattcata taggccagag ttgcaaagat 1740 cttttccaga gtatgcaact ctgacgttga tcccagagag cagcttcagt gacaaacata 1800 tcctttcaag acagaaagag acaggagaca tgagtctttg ccggaggaaa agcagctcaa 1860 gaacacatgt gcagtcactg gtgtcaccct ggataggcaa gggataactc ttctaacaca 1920 aaataagtgt tttatgtttg gaataaagtc aaccttgttt ctactgtttt a 1971 <210> 244 <211> 3514 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3514) <223> MMP2 mRNA <400> 244 gctgcatcca gacttcctca ggcggtggct ggaggctgcg catctggggc tttaaacata 60 caaagggatt gccaggacct gcggcggcgg cggcggcggc gggggctggg gcgcgggggc 120 cggaccatga gccgctgagc cgggcaaacc ccaggccacc gagccagcgg accctcggag 180 cgcagccctg cgccgcggag caggctccaa ccaggcggcg aggcggccac acgcaccgag 240 ccagcgaccc ccgggcgacg cgcggggcca gggagcgcta cgatggaggc gctaatggcc 300 cggggcgcgc tcacgggtcc cctgagggcg ctctgtctcc tgggctgcct gctgagccac 360 gccgccgccg cgccgtcgcc catcatcaag ttccccggcg atgtcgcccc caaaacggac 420 aaagagttgg cagtgcaata cctgaacacc ttctatggct gccccaagga gagctgcaac 480 ctgtttgtgc tgaaggacac actaaagaag atgcagaagt tctttggact gccccagaca 540 ggtgatcttg accagaatac catcgagacc atgcggaagc cacgctgcgg caacccagat 600 gtggccaact acaacttctt ccctcgcaag cccaagtggg acaagaacca gatcacatac 660 aggatcattg gctacacacc tgatctggac ccagagacag tggatgatgc ctttgctcgt 720 gccttccaag tctggagcga tgtgacccca ctgcggtttt ctcgaatcca tgatggagag 780 gcagacatca tgatcaactt tggccgctgg gagcatggcg atggataccc ctttgacggt 840 aaggacggac tcctggctca tgccttcgcc ccaggcactg gtgttggggg agactcccat 900 tttgatgacg atgagctatg gaccttggga gaaggccaag tggtccgtgt gaagtatggg 960 aacgccgatg gggagtactg caagttcccc ttcttgttca atggcaagga gtacaacagc 1020 tgcactgata ccggccgcag cgatggcttc ctctggtgct ccaccaccta caactttgag 1080 aaggatggca agtacggctt ctgtccccat gaagccctgt tcaccatggg cggcaacgct 1140 gaaggacagc cctgcaagtt tccattccgc ttccagggca catcctatga cagctgcacc 1200 actgagggcc gcacggatgg ctaccgctgg tgcggcacca ctgaggacta cgaccgcgac 1260 aagaagtatg gcttctgccc tgagaccgcc atgtccactg ttggtgggaa ctcagaaggt 1320 gccccctgtg tcttcccctt cactttcctg ggcaacaaat atgagagctg caccagcgcc 1380 ggccgcagtg acggaaagat gtggtgtgcg accacagcca actacgatga tgaccgcaag 1440 tggggcttct gccctgacca agggtacagc ctgttcctcg tggcagccca cgagtttggc 1500 cacgccatgg ggctggagca ctcccaagac cctggggccc tgatggcacc catttacacc 1560 tacaccaaga acttccgtct gtcccaggat gacatcaagg gcattcagga gctctatggg 1620 gcctctcctg acattgacct tggcaccggc cccaccccca cgctgggccc tgtcactcct 1680 gagatctgca aacaggacat tgtatttgat ggcatcgctc agatccgtgg tgagatcttc 1740 ttcttcaagg accggttcat ttggcggact gtgacgccac gtgacaagcc catggggccc 1800 ctgctggtgg ccacattctg gcctgagctc ccggaaaaga ttgatgcggt atacgaggcc 1860 ccacaggagg agaaggctgt gttctttgca gggaatgaat actggatcta ctcagccagc 1920 accctggagc gagggtaccc caagccactg accagcctgg gactgccccc tgatgtccag 1980 cgagtggatg ccgcctttaa ctggagcaaa aacaagaaga catacatctt tgctggagac 2040 aaattctgga gatacaatga ggtgaagaag aaaatggatc ctggcttccc caagctcatc 2100 gcagatgcct ggaatgccat ccccgataac ctggatgccg tcgtggacct gcagggcggc 2160 ggtcacagct acttcttcaa gggtgcctat tacctgaagc tggagaacca aagtctgaag 2220 agcgtgaagt ttggaagcat caaatccgac tggctaggct gctgagctgg ccctggctcc 2280 cacaggccct tcctctccac tgccttcgat acaccgggcc tggagaacta gagaaggacc 2340 cggaggggcc tggcagccgt gccttcagct ctacagctaa tcagcattct cactcctacc 2400 tggtaattta agattccaga gagtggctcc tcccggtgcc caagaataga tgctgactgt 2460 actcctccca ggcgcccctt ccccctccaa tcccaccaac cctcagagcc acccctaaag 2520 agatactttg atattttcaa cgcagccctg ctttgggctg ccctggtgct gccacacttc 2580 aggctcttct cctttcacaa ccttctgtgg ctcacagaac ccttggagcc aatggagact 2640 gtctcaagag ggcactggtg gcccgacagc ctggcacagg gcagtgggac agggcatggc 2700 caggtggcca ctccagaccc ctggcttttc actgctggct gccttagaac ctttcttaca 2760 ttagcagttt gctttgtatg cactttgttt ttttctttgg gtcttgtttt ttttttccac 2820 ttagaaattg catttcctga cagaaggact caggttgtct gaagtcactg cacagtgcat 2880 ctcagcccac atagtgatgg ttcccctgtt cactctactt agcatgtccc taccgagtct 2940 cttctccact ggatggagga aaaccaagcc gtggcttccc gctcagccct ccctgcccct 3000 cccttcaacc attccccatg ggaaatgtca acaagtatga ataaagacac ctactgagtg 3060 gccgtgtttg ccatctgttt tagcagagcc tagacaaggg ccacagaccc agccagaagc 3120 ggaaacttaa aaagtccgaa tctctgctcc ctgcagggca caggtgatgg tgtctgctgg 3180 aaaggtcaga gcttccaaag taaacagcaa gagaacctca gggagagtaa gctctagtcc 3240 ctctgtcctg tagaaagagc cctgaagaat cagcaatttt gttgctttat tgtggcatct 3300 gttcgaggtt tgcttcctct ttaagtctgt ttcttcatta gcaatcatat cagttttaat 3360 gctactacta acaatgaaca gtaacaataa tatccccctc aattaataga gtgctttcta 3420 tgtgcaaggc acttttcacg tgtcacctat tttaaccttt ccaaccacat aaataaaaaa 3480 ggccattatt agttgaatct tattgatgaa gaga 3514 <210> 245 <211> 1906 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1906) <223> MMP3 mRNA <400> 245 aaagcaagga tgagtcaagc tgcgggtgat ccaaacaaac actgtcactc tttaaaagct 60 gcgctcccga ggttggacct acaaggaggc aggcaagaca gcaaggcata gagacaacat 120 agagctaagt aaagccagtg gaaatgaaga gtcttccaat cctactgttg ctgtgcgtgg 180 cagtttgctc agcctatcca ttggatggag ctgcaagggg tgaggacacc agcatgaacc 240 ttgttcagaa atatctagaa aactactacg acctcaaaaa agatgtgaaa cagtttgtta 300 ggagaaagga cagtggtcct gttgttaaaa aaatccgaga aatgcagaag ttccttggat 360 tggaggtgac ggggaagctg gactccgaca ctctggaggt gatgcgcaag cccaggtgtg 420 gagttcctga tgttggtcac ttcagaacct ttcctggcat cccgaagtgg aggaaaaccc 480 accttacata caggattgtg aattatacac cagatttgcc aaaagatgct gttgattctg 540 ctgttgagaa agctctgaaa gtctgggaag aggtgactcc actcacattc tccaggctgt 600 atgaaggaga ggctgatata atgatctctt ttgcagttag agaacatgga gacttttacc 660 cttttgatgg acctggaaat gttttggccc atgcctatgc ccctgggcca gggattaatg 720 gagatgccca ctttgatgat gatgaacaat ggacaaagga tacaacaggg accaatttat 780 ttctcgttgc tgctcatgaa attggccact ccctgggtct ctttcactca gccaacactg 840 aagctttgat gtacccactc tatcactcac tcacagacct gactcggttc cgcctgtctc 900 aagatgatat aaatggcatt cagtccctct atggacctcc ccctgactcc cctgagaccc 960 ccctggtacc cacggaacct gtccctccag aacctgggac gccagccaac tgtgatcctg 1020 ctttgtcctt tgatgctgtc agcactctga ggggagaaat cctgatcttt aaagacaggc 1080 acttttggcg caaatccctc aggaagcttg aacctgaatt gcatttgatc tcttcatttt 1140 ggccatctct tccttcaggc gtggatgccg catatgaagt tactagcaag gacctcgttt 1200 tcatttttaa aggaaatcaa ttctgggcta tcagaggaaa tgaggtacga gctggatacc 1260 caagaggcat ccacacccta ggtttccctc caaccgtgag gaaaatcgat gcagccattt 1320 ctgataagga aaagaacaaa acatatttct ttgtagagga caaatactgg agatttgatg 1380 agaagagaaa ttccatggag ccaggctttc ccaagcaaat agctgaagac tttccaggga 1440 ttgactcaaa gattgatgct gtttttgaag aatttgggtt cttttatttc tttactggat 1500 cttcacagtt ggagtttgac ccaaatgcaa agaaagtgac acacactttg aagagtaaca 1560 gctggcttaa ttgttgaaag agatatgtag aaggcacaat atgggcactt taaatgaagc 1620 taataattct tcacctaagt ctctgtgaat tgaaatgttc gttttctcct gcctgtgctg 1680 tgactcgagt cacactcaag ggaacttgag cgtgaatctg tatcttgccg gtcattttta 1740 tgttattaca gggcattcaa atgggctgct gcttagcttg caccttgtca catagagtga 1800 tctttcccaa gagaagggga agcactcgtg tgcaacagac aagtgactgt atctgtgtag 1860 actatttgct tatttaataa agacgatttg tcagttattt tatctt 1906 <210> 246 <211> 4593 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4593) <223> VISFATIN mRNA <400> 246 gctgccgcgc cccgcccttt ctcggccccc ggagggtgac ggggtgaagg cgggggaacc 60 gaggtgggga gtccgccaga gctcccagac tgcgagcacg cgagccgccg cagccgtcac 120 ccgcgccgcg tcacggctcc cgggcccgcc ctcctctgac ccctcccctc tctccgtttc 180 cccctctccc cctcctccgc cgaccgagca gtgacttaag caacggagcg cggtgaagct 240 catttttctc cttcctcgca gccgcgccag ggagctcgcg gcgcgcggcc cctgtcctcc 300 ggcccgagat gaatcctgcg gcagaagccg agttcaacat cctcctggcc accgactcct 360 acaaggttac tcactataaa caatatccac ccaacacaag caaagtttat tcctactttg 420 aatgccgtga aaagaagaca gaaaactcca aattaaggaa ggtgaaatat gaggaaacag 480 tattttatgg gttgcagtac attcttaata agtacttaaa aggtaaagta gtaaccaaag 540 agaaaatcca ggaagccaaa gatgtctaca aagaacattt ccaagatgat gtctttaatg 600 aaaagggatg gaactacatt cttgagaagt atgatgggca tcttccaata gaaataaaag 660 ctgttcctga gggctttgtc attcccagag gaaatgttct cttcacggtg gaaaacacag 720 atccagagtg ttactggctt acaaattgga ttgagactat tcttgttcag tcctggtatc 780 caatcacagt ggccacaaat tctagagagc agaagaaaat attggccaaa tatttgttag 840 aaacttctgg taacttagat ggtctggaat acaagttaca tgattttggc tacagaggag 900 tctcttccca agagactgct ggcataggag catctgctca cttggttaac ttcaaaggaa 960 cagatacagt agcaggactt gctctaatta aaaaatatta tggaacgaaa gatcctgttc 1020 caggctattc tgttccagca gcagaacaca gtaccataac agcttggggg aaagaccatg 1080 aaaaagatgc ttttgaacat attgtaacac agttttcatc agtgcctgta tctgtggtca 1140 gcgatagcta tgacatttat aatgcgtgtg agaaaatatg gggtgaagat ctaagacatt 1200 taatagtatc aagaagtaca caggcaccac taataatcag acctgattct ggaaaccctc 1260 ttgacactgt gttaaaggtt ttggagattt taggtaagaa gtttcctgtt actgagaact 1320 caaagggtta caagttgctg ccaccttatc ttagagttat tcaaggggat ggagtagata 1380 ttaatacctt acaagagatt gtagaaggca tgaaacaaaa aatgtggagt attgaaaata 1440 ttgccttcgg ttctggtgga ggtttgctac agaagttgac aagagatctc ttgaattgtt 1500 ccttcaagtg tagctatgtt gtaactaatg gccttgggat taacgtcttc aaggacccag 1560 ttgctgatcc caacaaaagg tccaaaaagg gccgattatc tttacatagg acgccagcag 1620 ggaattttgt tacactggag gaaggaaaag gagaccttga ggaatatggt caggatcttc 1680 tccatactgt cttcaagaat ggcaaggtga caaaaagcta ttcatttgat gaaataagaa 1740 aaaatgcaca gctgaatatt gaactggaag cagcacatca ttaggcttta tgactgggtg 1800 tgtgttgtgt gtatgtaata cataatgttt attgtacaga tgtgtggggt ttgtgtttta 1860 tgatacatta cagccaaatt atttgttggt ttatggacat actgcccttt catttttttt 1920 cttttccagt gtttaggtga tctcaaatta ggaaatgcat ttaaccatgt aaaagatgag 1980 tgctaaagta agctttttag ggccctttgc caataggtag tcattcaatc tggtattgat 2040 cttttcacaa ataacagaac tgagaaactt ttatatataa ctgatgatca cataaaacag 2100 atttgcataa aattaccatg attgctttat gtttatattt aacttgtatt tttgtacaaa 2160 caagattgtg taagatatat ttgaagtttc agtgatttaa cagtctttcc aacttttcat 2220 gatttttatg agcacagact ttcaagaaaa tacttgaaaa taaattacat tgccttttgt 2280 ccattaatca gcaaataaaa catggcctta acaaagttgt ttgtgttatt gtacaatttg 2340 aaaattatgt cgggacatac cctatagaat tactaacctt actgcccctt gtagaatatg 2400 tattaatcat tctacattaa agaaaataat ggttcttact ggaatgtcta ggcactgtac 2460 agttattata tatcttggtt gttgtattgt accagtgaaa tgccaaattt gaaaggcctg 2520 tactgcaatt ttatatgtca gagattgcct gtggctctaa tatgcacctc aagattttaa 2580 ggagataatg tttttagaga gaatttctgc ttccactata gaatatatac ataaatgtaa 2640 aatacttaca aaagtggaag tagtgtattt taaagtaatt acacttctga atttattttt 2700 catattctat agttggtatg acttaaatga attactggag tgggtagtga gtgtacttaa 2760 atgtttcaat tctgttatat tttttattaa gtttttaaaa aattaaattg gatattaaat 2820 tgtatggaca tcatttatta attttaaact gaatgccctc aataagtaat actgaagcac 2880 attcttaaat gaagataaat tatctccaat gaaaagcatg acatgtgttt caatagaaga 2940 atcttaagtt ggctaaattc aaagtgcttg acatcaaaat gttctagagt gattagctac 3000 tagattctga atcatacatc acatctgact agagaccagt ttctttcgaa tgattctttt 3060 atgtatgtag atctgttctt ctgaggcagc ggttggccaa ctatagccca aaggccaaat 3120 ttggacttct ttttataaat gcagattgtc tatggctgct ttcccactac tccagcctaa 3180 ggtaaacagc tgcaatagaa gccaaatgag aatcgcaaag cccaaaatgt ttattaacct 3240 gccctttaca caaaattaca caaaaagttt cctgatctct gttctaagaa aaggagtgtg 3300 ccttgcattt aaaaggaaat gttggtttct agggaaggga ggaggctaaa taattgatac 3360 ggaattttcc tcttttgtct tcttttttct cacttaagaa tccgatactg gaagactgat 3420 ttagaaaagt ttttaacatg acattaaatg tgaaatttta aaaattgaaa agccataaat 3480 catctgtttt aaatagttac atgagaaaat gatcactaga ataacctaat tagaagtgtt 3540 atcttcatta aatgtttttt gtaagtggta ttagaaagaa tatgtttttc agatggttct 3600 ttaaacatgt agtgagaaca ataagcatta ttcactttta gtaagtcttc tgtaatccat 3660 gatataaaat aattttaaaa tgatttttta atgtatttga gtaaagatga gtagtattaa 3720 gaaaaacaca catttcttca caaaatgtgc taaggggcgt gtaaagaatc aaaagaaact 3780 attaccaata atagttttga taatcaccca taattttgtg tttaaacatt gaaattatag 3840 tacagacagt attctctgtg ttctgtgaat ttcagcagct tcagaataga gtttaattta 3900 gaaatttgca gtgaaaaaag ctatctcttt gttcacaacc ataaatcagg agatggagat 3960 taattctatt ggctcttagt cacttggaac tgattaattc tgactttctg tcactaagca 4020 cttggtattt ggccatctcc attctgagca ccaaacggtt aacacgaatg tccactagaa 4080 ctctgctgtg tgtcaccctt aaatcagtct aaatcttcca gacaaaagca aatggcattt 4140 atggatttaa gtcattagat tttcaactga cattaattaa tccctcttga ttgattatat 4200 catcaagtat ttatatctta aataggaggt aggatttctg tgttaagact cttatttgta 4260 ccctataatt aaagtaaaat gttttttatg agtatccctt gttttccctt cttaaattgt 4320 tatcaaacaa tttttataat gaaatctatc ttggaaaatt agaaagaaaa atggcaaggt 4380 atttattgtt ctgtttgcca taatttagaa ctcacactta agtattttgt agttttacat 4440 tcctttttaa cccattcagt ggagaatgtc agcttttctc ccaagttgta tgttaagtct 4500 attctaatat gtactcaaca tcaagttata aacatgtaat aaacatggaa ataaagttta 4560 gctctattag tgaagtgtta aaaaaaaaaa aaa 4593 <210> 247 <211> 4020 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4020) <223> NPAS2 mRNA <400> 247 gcgtgcggaa gagtttgccg cgcgagcagc cggcctctcg caggagccga gggacccgcg 60 cggctgcggc ccaggagcgg cggccgcgga gcccggagac ccgcagccgc ggcggcggcg 120 gcggcggcgg cagcagctag agcagcgcct cccgccgccg cccgggagga gctcgccgcg 180 cccgctcgcc gcctcgtctc ccagcggcgg cgggaggcgc gtctccccgg cccagtccgc 240 gcccggcccc gcggggccgc tccggcccgc tccgaggaaa aactgcatag aaaatctaat 300 ggatgaagat gagaaagaca gagccaagag agcttctcga aacaagtctg agaagaagcg 360 tcgggaccag ttcaatgttc tcatcaaaga gctcagttcc atgctccctg gcaacacgcg 420 gaaaatggac aaaaccaccg tgttggaaaa ggtcatcgga tttttgcaga aacacaatga 480 agtctcagcg caaacggaaa tctgtgacat tcagcaagac tggaagcctt cattcctcag 540 taatgaagaa ttcacccagc tgatgttgga ggcattagat ggcttcatta tcgcagtgac 600 aacagacggc agcatcatct atgtctctga cagtatcacg cctctccttg ggcatttacc 660 gtcggatgtc atggatcaga atttgttaaa tttcctccca gaacaagaac attcagaagt 720 ttataaaatc ctttcttccc atatgcttgt gacggattcc ccctccccag aatacttaaa 780 atctgacagc gatttagagt tttattgcca tcttctcaga ggcagcttga acccaaagga 840 atttccaact tatgaataca taaaatttgt aggaaatttt cgctcttaca acaatgtgcc 900 tagcccctcc tgtaatggtt ttgacaacac cctttcaaga ccttgccggg tgccactagg 960 aaaggaggtt tgcttcattg ccaccgttcg tctggcaaca ccacaattct taaaggaaat 1020 gtgcatagtt gacgaacctt tagaggaatt cacttcaagg catagcttgg aatggaaatt 1080 tttatttctg gatcacagag cacctccaat cataggatac ctgccttttg aagtgctggg 1140 aacctcaggc tatgactact accacattga tgacctggag ctcctggcca ggtgtcacca 1200 gcacctgatg cagtttggca aagggaagtc gtgttgctac cggtttctga ccaaaggtca 1260 gcagtggatc tggctgcaga ctcactacta catcacctac catcagtgga actccaagcc 1320 cgagttcatc gtgtgcacac actcggtggt cagttacgca gatgtccggg tggaaaggag 1380 gcaggagctg gctctggaag acccgccatc cgaggccctc cactcctcag cactaaagga 1440 caagggctca agcctggaac ctcggcagca ctttaacaca ctcgacgtgg gtgcctcggg 1500 ccttaatacc agtcattcgc catcggcgtc ctcaagaagt tcccacaaat cctcgcacac 1560 agccatgtca gaacccacct ccactcccac caagctgatg gcagaggcca gcaccccggc 1620 tttgccaaga tcagccaccc tgccccaaga gttacctgtc cccgggctca gccaggcagc 1680 caccatgccg gcccctctgc cttccccatc gtcctgcgac ctcacacagc agctcctgcc 1740 tcagaccgtt ctgcagagca cgcccgctcc catggcacag ttttcggcac agttcagcat 1800 gttccagacc atcaaagacc agctagagca gcggacgcgg atcctgcagg ccaatatccg 1860 gtggcaacag gaagagctcc acaagatcca ggagcagctc tgcctggtcc aggactccaa 1920 cgtccagatg ttcctgcagc agccagctgt atccctgagc ttcagcagca cccagcgacc 1980 tgaggctcag cagcagctac agcaaaggtc agctgcagtg actcagcccc agctcggggc 2040 gggcccccaa cttccagggc agatctcctc tgcccaggtc acaagccagc acctgctcag 2100 agaatcaagt gtgatatcaa cccagggtcc aaagccaatg agaagctcac agctaatgca 2160 gagcagcggc cgctctggaa gcagcctagt gtccccgttc agcagcgcca cagctgcgct 2220 cccgccaagt ctgaatctga ccacacctgc ttccacctcc caggatgcca gccagtgcca 2280 gcccagccca gacttcagcc atgatcggca gctcaggctg ttgctgagcc agcccatcca 2340 gcccatgatg cccgggtcct gtgacgcaag gcagccctcg gaagtcagca ggacgggacg 2400 gcaagtcaag tacgcccaga gccagaccgt gtttcaaaat ccagacgcac accccgccaa 2460 cagcagcagc gccccgatgc ccgtcctgct gatggggcag gcggtgctcc accccagctt 2520 ccctgcctcc caaccatcgc ccctgcagcc tgcacaggcc cggcagcagc caccgcagca 2580 ctacctgcag gtacaggcac caacctcttt gcacagtgag cagcaggact cgctacttct 2640 ctccacctac tcacaacagc cagggaccct gggctacccc caaccacccc cagcacagcc 2700 ccagccccta cgtcctcccc gaagggtcag cagtctgtct gagtcgtcag gcctccagca 2760 gccgccccga taatgccccg gcactgaagt cgggacacaa tcagctttaa ccaatggatg 2820 aggggggtgg ccacaggaga tggggagagg agtctgaact aaacccctgg cttttgtgca 2880 cactgcatac gtttcagaac tcctggatgg taaccatctc tggagtgcag cgcttgctgc 2940 agtggaaatg atcaggaata ctgaccgtgt ttctcttgcc tccgaggttc ttgggcacac 3000 tctatagcca tactggacag gaaccaggtg ccccgtgtag gcatcgtcgg tcggtttgcc 3060 gtcagagatg gcgcatctcg ctgcatcccc cgagagtaca ccggttgctc tagccacctg 3120 cggcccgccc atctgcgcta gctggccttc acgctcttga tcgtctttcc tttgtattgg 3180 agaaggactg ggtcagagat ctgttggaga gagagaataa agagattatt tttcattatt 3240 tttaaatggt tgtttttgtt ttaatttgca cagctacaca gaggaaataa cttaggcact 3300 ttctgttttt tttaaaaaaa taataaggtc tcatggcttc atttagagac cacagtaaca 3360 acagcagccc accaatcaga gaagctggtt gttattaacc aagctacaga ttcacacttt 3420 ctggcctaaa ccctaatggg atgaggcttt tcaccccagg ccatgctggt ggtgattttt 3480 tagcccctaa ataaaacact ggactatttc ctgtttactt cattgattgc aactacaaag 3540 gtggactcaa agcaaagcac aatcatgcca gccaacattc cagaattctg ctgagaactc 3600 caagtctgtg aggggagagg ttttacaagc cagacaggcc tgggggactg cagtccccaa 3660 ggagaccctg ccacatgctg gccctttgag tgagaatgct gcatctttct acatatcttc 3720 atgagaatac tgagaattgg attttccttt tcaaaatgca ctttgctttt tttgtatgtt 3780 ttgttatgtt gagatgtttc taaagaaaag attttatgta attataagat gaagcgtagt 3840 gaattgtaca gctgttgtaa taatgaccta tttctatata aaataaaatt gtatggctta 3900 tgtgtaaatt attttgtatc tgagatacca gttccttttc ccaaatataa aagtataaaa 3960 gttttcttgt gtttttctgt gagtgaaaat tttgtaataa attaacaaat ttgtacaatt 4020 4020 <210> 248 <211> 2809 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2809) <223> PDGFA mRNA <400> 248 acgcgcgccc tgcggagccc gcccaactcc ggcgagccgg gcctgcgcct actcctcctc 60 ctcctctccc ggcggcggct gcggcggagg cgccgactcg gccttgcgcc cgccctcagg 120 cccgcgcggg cggcgcagcg aggccccggg cggcgggtgg tggctgccag gcggctcggc 180 cgcgggcgct gcccggcccc ggcgagcgga gggcggagcg cggcgccgga gccgagggcg 240 cgccgcggag ggggtgctgg gccgcgctgt gcccggccgg gcggcggctg caagaggagg 300 ccggaggcga gcgcggggcc ggcggtgggc gcgcagggcg gctcgcagct cgcagccggg 360 gccgggccag gcgtccaggc aggtgatcgg tgtggcggcg gcggcggcgg cggccccaga 420 ctccctccgg agttcttctt ggggctgatg tccgcaaata tgcagaatta ccggccgggt 480 cgctcctgaa gccagcgcgg ggagcgagcg cggcggcggc cagcaccggg aacgcaccga 540 ggaagaagcc cagcccccgc cctccgcccc ttccgtcccc accccctacc cggcggccca 600 ggaggctccc cgcgctgcgg gcgcgcactc cctgtttctc ctcctcctgg ctggcgctgc 660 ctgcctctcc gcactcactg ctcgcgccgg gcgcgctccg ccagctccgt gctccccgcg 720 ccaccctcct ccgggccgcg ctccctaagg gatggtactg aatttcgccg ccacaggaga 780 ccggctggag cgcccgcccc gcggcctcgc ctctcctccg agcagccagc gcctcgggac 840 gcgatgagga ccttggcttg cctgctgctc ctcggctgcg gatacctcgc ccatgttctg 900 gccgaggaag ccgagatccc ccgcgaggtg atcgagaggc tggcccgcag tcagatccac 960 agcatccggg acctccagcg actcctggag atagactccg tagggagtga ggattctttg 1020 gacaccagcc tgagagctca cggggtccat gccactaagc atgtgcccga gaagcggccc 1080 ctgcccattc ggaggaagag aagcatcgag gaagctgtcc ccgctgtctg caagaccagg 1140 acggtcattt acgagattcc tcggagtcag gtcgacccca cgtccgccaa cttcctgatc 1200 tggcccccgt gcgtggaggt gaaacgctgc accggctgct gcaacacgag cagtgtcaag 1260 tgccagccct cccgcgtcca ccaccgcagc gtcaaggtgg ccaaggtgga atacgtcagg 1320 aagaagccaa aattaaaaga agtccaggtg aggttagagg agcatttgga gtgcgcctgc 1380 gcgaccacaa gcctgaatcc ggattatcgg gaagaggaca cgggaaggcc tagggagtca 1440 ggtaaaaaac ggaaaagaaa aaggttaaaa cccacctaaa gcagccaacc agatgtgagg 1500 tgaggatgag ccgcagccct ttcctgggac atggatgtac atggcgtgtt acattcctga 1560 acctactatg tacggtgctt tattgccagt gtgcggtctt tgttctcctc cgtgaaaaac 1620 tgtgtccgag aacactcggg agaacaaaga gacagtgcac atttgtttaa tgtgacatca 1680 aagcaagtat tgtagcactc ggtgaagcag taagaagctt ccttgtcaaa aagagagaga 1740 gagaaagaga gagagaaaac aaaaccacaa atgacaaaaa caaaacggac tcacaaaaat 1800 atctaaactc gatgagatgg agggtcgccc cgtgggatgg aagtgcagag gtctcagcag 1860 actggatttc tgtccgggtg gtcacaggtg cttttttgcc gaggatgcag agcctgcttt 1920 gggaacgact ccagaggggt gctggtgggc tctgcagggg cccgcaggaa gcaggaatgt 1980 cttggaaacc gccacgcgaa ctttagaaac cacacctcct cgctgtagta tttaagccca 2040 tacagaaacc ttcctgagag ccttaagtgg tttttttttt tgtttttgtt ttgttttttt 2100 tttttttgtt tttttttttt tttttttaca ccataaagtg attattaagc tttccttttt 2160 actctttggc tagctttttt tttttttttt tttttttaat tatctcttgg atgacattta 2220 caccgataac acacaggctg ctgtaactgt caggacagtg cgacggtatt tttcctagca 2280 agatgcaaac taatgagatg tattaaaata aacatggtat acctacctat gcatcatttc 2340 ctaaatgttt ctggctttgt gtttctccct taccctgctt tatttgttaa tttaagccat 2400 tttgaaagaa ctatgcgtca accaatcgta cgccgtccct gcggcacctg ccccagagcc 2460 cgtttgtggc tgagtgacaa cttgttcccc gcagtgcaca cctagaatgc tgtgttccca 2520 cgcggcacgt gagatgcatt gccgcttctg tctgtgttgt tggtgtgccc tggtgccgtg 2580 gtggcggtca ctccctctgc tgccagtgtt tggacagaac ccaaattctt tatttttggt 2640 aagatattgt gctttacctg tattaacaga aatgtgtgtg tgtggtttgt ttttttgtaa 2700 aggtgaagtt tgtatgttta cctaatatta cctgttttgt atacctgaga gcctgctatg 2760 ttcttttttt gttgatccaa aattaaaaaa aaaaatacca ccaacaaaa 2809 <210> 249 <211> 3221 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3221) <223> PLAT mRNA <400> 249 gaacttcctc cccctgcttt ataaaaacag gcctgcctca gctccctcat ggccctgtcc 60 actgagcatc ctcccgccac acagaaaccc gcccagccgg ggccaccgac cccaccccct 120 gcctggaaac ttaaaggagg ccggagctgt ggggagctca gagctgagat cctacaggag 180 tccagggctg gagagaaaac ctctgcgagg aaagggaagg agcaagccgt gaatttaagg 240 gacgctgtga agcaatcatg gatgcaatga agagagggct ctgctgtgtg ctgctgctgt 300 gtggagcagt cttcgtttcg cccagccagg aaatccatgc ccgattcaga agaggagcca 360 gatcttacca agtgatctgc agagatgaaa aaacgcagat gatataccag caacatcagt 420 catggctgcg ccctgtgctc agaagcaacc gggtggaata ttgctggtgc aacagtggca 480 gggcacagtg ccactcagtg cctgtcaaaa gttgcagcga gccaaggtgt ttcaacgggg 540 gcacctgcca gcaggccctg tacttctcag atttcgtgtg ccagtgcccc gaaggatttg 600 ctgggaagtg ctgtgaaata gataccaggg ccacgtgcta cgaggaccag ggcatcagct 660 acaggggcac gtggagcaca gcggagagtg gcgccgagtg caccaactgg aacagcagcg 720 cgttggccca gaagccctac agcgggcgga ggccagacgc catcaggctg ggcctgggga 780 accacaacta ctgcagaaac ccagatcgag actcaaagcc ctggtgctac gtctttaagg 840 cggggaagta cagctcagag ttctgcagca cccctgcctg ctctgaggga aacagtgact 900 gctactttgg gaatgggtca gcctaccgtg gcacgcacag cctcaccgag tcgggtgcct 960 cctgcctccc gtggaattcc atgatcctga taggcaaggt ttacacagca cagaacccca 1020 gtgcccaggc actgggcctg ggcaaacata attactgccg gaatcctgat ggggatgcca 1080 agccctggtg ccacgtgctg aagaaccgca ggctgacgtg ggagtactgt gatgtgccct 1140 cctgctccac ctgcggcctg agacagtaca gccagcctca gtttcgcatc aaaggagggc 1200 tcttcgccga catcgcctcc cacccctggc aggctgccat ctttgccaag cacaggaggt 1260 cgcccggaga gcggttcctg tgcgggggca tactcatcag ctcctgctgg attctctctg 1320 ccgcccactg cttccaggag aggtttccgc cccaccacct gacggtgatc ttgggcagaa 1380 cataccgggt ggtccctggc gaggaggagc agaaatttga agtcgaaaaa tacattgtcc 1440 ataaggaatt cgatgatgac acttacgaca atgacattgc gctgctgcag ctgaaatcgg 1500 attcgtcccg ctgtgcccag gagagcagcg tggtccgcac tgtgtgcctt cccccggcgg 1560 acctgcagct gccggactgg acggagtgtg agctctccgg ctacggcaag catgaggcct 1620 tgtctccttt ctattcggag cggctgaagg aggctcatgt cagactgtac ccatccagcc 1680 gctgcacatc acaacattta cttaacagaa cagtcaccga caacatgctg tgtgctggag 1740 acactcggag cggcgggccc caggcaaact tgcacgacgc ctgccagggc gattcgggag 1800 gccccctggt gtgtctgaac gatggccgca tgactttggt gggcatcatc agctggggcc 1860 tgggctgtgg acagaaggat gtcccgggtg tgtacaccaa ggttaccaac tacctagact 1920 ggattcgtga caacatgcga ccgtgaccag gaacacccga ctcctcaaaa gcaaatgaga 1980 tcccgcctct tcttcttcag aagacactgc aaaggcgcag tgcttctcta cagacttctc 2040 cagacccacc acaccgcaga agcgggacga gaccctacag gagagggaag agtgcatttt 2100 cccagatact tcccattttg gaagttttca ggacttggtc tgatttcagg atactctgtc 2160 agatgggaag acatgaatgc acactagcct ctccaggaat gcctcctccc tgggcagaaa 2220 gtggccatgc caccctgttt tcagctaaag cccaacctcc tgacctgtca ccgtgagcag 2280 ctttggaaac aggaccacaa aaatgaaagc atgtctcaat agtaaaagat aacaagatct 2340 ttcaggaaag acggattgca ttagaaatag acagtatatt tatagtcaca agagcccagc 2400 agggcctcaa agttggggca ggctggctgg cccgtcatgt tcctcaaaag cacccttgac 2460 gtcaagtctc cttccccttt ccccactccc tggctctcag aaggtattcc ttttgtgtac 2520 agtgtgtaaa gtgtaaatcc tttttcttta taaactttag agtagcatga gagaattgta 2580 tcatttgaac aactaggctt cagcatattt atagcaatcc atgttagttt ttactttctg 2640 ttgccacaac cctgttttat actgtactta ataaattcag atatattttt cacagttttt 2700 ccaaaatcag agtggaatgg ttttgttata gatgctgtat cccactcttt attcatgttc 2760 acattttaaa atcatttgga attctgcttc actcgcttaa catatacaca acacctgtaa 2820 catacaaggc aatgggctag gtgctccaga ccgggaaaag gagggacagg aatgcttggt 2880 ctgatgggct aatatggcat ttagagaagt accaaggtac agtggagccg gtcacaaaag 2940 ggcagacttg tagtagaatt cagttgcaag agggattggg gaatcttaag gaaaaaatag 3000 aatcttaagg aaaaaataac tgggtgagac gtggactgtg gacaggtgtg gaaaaggcac 3060 tctccatgga ggtatgaata tgtagagggc caagagaggg gagtacaggg agaaatgagt 3120 tgagcttgtc tgaagtgaac ttcaggaaga ggaacatagg ctggaattta gattatgggg 3180 gctctgaaca ccaaactgag tttggactta attgacttct g 3221 <210> 250 <211> 2398 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2398) <223> PLAU mRNA <400> 250 ctgatataga gcaggcgccg cgggtcgcag cacagtgcgg agaccgcagc cccggagccc 60 gggccagggt ccacctgtcc ccgcagcgcc ggctcgcgcc ctcctgccgc agccaccgag 120 ccgccgtcta gcgccccgac ctcgccacca tgagagccct gctggcgcgc ctgcttctct 180 gcgtcctggt cgtgagcgac tccaaaggca gcaatgaact tcatcaagtt ccatcgaact 240 gtgactgtct aaatggagga acatgtgtgt ccaacaagta cttctccaac attcactggt 300 gcaactgccc aaagaaattc ggagggcagc actgtgaaat agataagtca aaaacctgct 360 atgaggggaa tggtcacttt taccgaggaa aggccagcac tgacaccatg ggccggccct 420 gcctgccctg gaactctgcc actgtccttc agcaaacgta ccatgcccac agatctgatg 480 ctcttcagct gggcctgggg aaacataatt actgcaggaa cccagacaac cggaggcgac 540 cctggtgcta tgtgcaggtg ggcctaaagc cgcttgtcca agagtgcatg gtgcatgact 600 gcgcagatgg aaaaaagccc tcctctcctc cagaagaatt aaaatttcag tgtggccaaa 660 agactctgag gccccgcttt aagattattg ggggagaatt caccaccatc gagaaccagc 720 cctggtttgc ggccatctac aggaggcacc gggggggctc tgtcacctac gtgtgtggag 780 gcagcctcat cagcccttgc tgggtgatca gcgccacaca ctgcttcatt gattacccaa 840 agaaggagga ctacatcgtc tacctgggtc gctcaaggct taactccaac acgcaagggg 900 agatgaagtt tgaggtggaa aacctcatcc tacacaagga ctacagcgct gacacgcttg 960 ctcaccacaa cgacattgcc ttgctgaaga tccgttccaa ggagggcagg tgtgcgcagc 1020 catcccggac tatacagacc atctgcctgc cctcgatgta taacgatccc cagtttggca 1080 caagctgtga gatcactggc tttggaaaag agaattctac cgactatctc tatccggagc 1140 agctgaaaat gactgttgtg aagctgattt cccaccggga gtgtcagcag ccccactact 1200 acggctctga agtcaccacc aaaatgctgt gtgctgctga cccacagtgg aaaacagatt 1260 cctgccaggg agactcaggg ggacccctcg tctgttccct ccaaggccgc atgactttga 1320 ctggaattgt gagctggggc cgtggatgtg ccctgaagga caagccaggc gtctacacga 1380 gagtctcaca cttcttaccc tggatccgca gtcacaccaa ggaagagaat ggcctggccc 1440 tctgagggtc cccagggagg aaacgggcac cacccgcttt cttgctggtt gtcatttttg 1500 cagtagagtc atctccatca gctgtaagaa gagactggga agataggctc tgcacagatg 1560 gatttgcctg tgccacccac cagggcgaac gacaatagct ttaccctcag gcataggcct 1620 gggtgctggc tgcccagacc cctctggcca ggatggaggg gtggtcctga ctcaacatgt 1680 tactgaccag caacttgtct ttttctggac tgaagcctgc aggagttaaa aagggcaggg 1740 catctcctgt gcatgggtga agggagagcc agctcccccg acggtgggca tttgtgaggc 1800 ccatggttga gaaatgaata atttcccaat taggaagtgt aacagctgag gtctcttgag 1860 ggagcttagc caatgtggga gcagcggttt ggggagcaga gacactaacg acttcagggc 1920 agggctctga tattccatga atgtatcagg aaatatatat gtgtgtgtat gtttgcacac 1980 ttgtgtgtgg gctgtgagtg taagtgtgag taagagctgg tgtctgattg ttaagtctaa 2040 atatttcctt aaactgtgtg gactgtgatg ccacacagag tggtctttct ggagaggtta 2100 taggtcactc ctggggcctc ttgggtcccc cacgtgacag tgcctgggaa tgtattattc 2160 tgcagcatga cctgtgacca gcactgtctc agtttcactt tcacatagat gtccctttct 2220 tggccagtta tcccttcctt ttagcctagt tcatccaatc ctcactgggt ggggtgagga 2280 ccactcctgt acactgaata tttatatttc actattttta tttatatttt tgtaatttta 2340 aataaaagtg atcaataaaa tgtgattttt ctgatgacaa aaaaaaaaaa aaaaaaaa 2398 <210> 251 <211> 1368 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1368) <223> PLAUR mRNA <400> 251 aggagagaag acgtgcaggg accccgcgca caggagctgc cctcgcgaca tgggtcaccc 60 gccgctgctg ccgctgctgc tgctgctcca cacctgcgtc ccagcctctt ggggcctgcg 120 gtgcatgcag tgtaagacca acggggattg ccgtgtggaa gagtgcgccc tgggacagga 180 cctctgcagg accacgatcg tgcgcttgtg ggaagaagga gaagagctgg agctggtgga 240 gaaaagctgt acccactcag agaagaccaa caggaccctg agctatcgga ctggcttgaa 300 gatcaccagc cttaccgagg ttgtgtgtgg gttagacttg tgcaaccagg gcaactctgg 360 ccgggctgtc acctattccc gaagccgtta cctcgaatgc atttcctgtg gctcatcaga 420 catgagctgt gagaggggcc ggcaccagag cctgcagtgc cgcagccctg aagaacagtg 480 cctggatgtg gtgacccact ggatccagga aggtgaagaa gggcgtccaa aggatgaccg 540 ccacctccgt ggctgtggct accttcccgg ctgcccgggc tccaatggtt tccacaacaa 600 cgacaccttc cacttcctga aatgctgcaa caccaccaaa tgcaacgagg gcccaatcct 660 ggagcttgaa aatctgccgc agaatggccg ccagtgttac agctgcaagg ggaacagcac 720 ccatggatgc tcctctgaag agactttcct cattgactgc cgaggcccca tgaatcaatg 780 tctggtagcc accggcactc acgaaccgaa aaaccaaagc tatatggtaa gaggctgtgc 840 aaccgcctca atgtgccaac atgcccacct gggtgacgcc ttcagcatga accacattga 900 tgtctcctgc tgtactaaaa gtggctgtaa ccacccagac ctggatgtcc agtaccgcag 960 tggggctgct cctcagcctg gccctgccca tctcagcctc accatcaccc tgctaatgac 1020 tgccagactg tggggaggca ctctcctctg gacctaaacc tgaaatcccc ctctctgccc 1080 tggctggatc cgggggaccc ctttgccctt ccctcggctc ccagccctac agacttgctg 1140 tgtgacctca ggccagtgtg ccgacctctc tgggcctcag ttttcccagc tatgaaaaca 1200 gctatctcac aaagttgtgt gaagcagaag agaaaagctg gaggaaggcc gtgggccaat 1260 gggagagctc ttgttattat taatattgtt gccgctgttg tgttgttgtt attaattaat 1320 attcatatta tttattttat acttacataa agattttgta ccagtgga 1368 <210> 252 <211> 3538 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3538) <223> PLG mRNA <400> 252 gaatcattaa cttaatttga ctatctggtt tgtggatgcg tttactctca tgtaagtcaa 60 caacatcctg ggattgggac ccactttctg ggcactgctg gccagtccca aaatggaaca 120 taaggaagtg gttcttctac ttcttttatt tctgaaatca ggtcaaggag agcctctgga 180 tgactatgtg aatacccagg gggcttcact gttcagtgtc actaagaagc agctgggagc 240 aggaagtata gaagaatgtg cagcaaaatg tgaggaggac gaagaattca cctgcagggc 300 attccaatat cacagtaaag agcaacaatg tgtgataatg gctgaaaaca ggaagtcctc 360 cataatcatt aggatgagag atgtagtttt atttgaaaag aaagtgtatc tctcagagtg 420 caagactggg aatggaaaga actacagagg gacgatgtcc aaaacaaaaa atggcatcac 480 ctgtcaaaaa tggagttcca cttctcccca cagacctaga ttctcacctg ctacacaccc 540 ctcagaggga ctggaggaga actactgcag gaatccagac aacgatccgc aggggccctg 600 gtgctatact actgatccag aaaagagata tgactactgc gacattcttg agtgtgaaga 660 ggaatgtatg cattgcagtg gagaaaacta tgacggcaaa atttccaaga ccatgtctgg 720 actggaatgc caggcctggg actctcagag cccacacgct catggataca ttccttccaa 780 atttccaaac aagaacctga agaagaatta ctgtcgtaac cccgataggg agctgcggcc 840 ttggtgtttc accaccgacc ccaacaagcg ctgggaactt tgtgacatcc cccgctgcac 900 aacacctcca ccatcttctg gtcccaccta ccagtgtctg aagggaacag gtgaaaacta 960 tcgcgggaat gtggctgtta ccgtgtccgg gcacacctgt cagcactgga gtgcacagac 1020 ccctcacaca cataacagga caccagaaaa cttcccctgc aaaaatttgg atgaaaacta 1080 ctgccgcaat cctgacggaa aaagggcccc atggtgccat acaaccaaca gccaagtgcg 1140 gtgggagtac tgtaagatac cgtcctgtga ctcctcccca gtatccacgg aacaattggc 1200 tcccacagca ccacctgagc taacccctgt ggtccaggac tgctaccatg gtgatggaca 1260 gagctaccga ggcacatcct ccaccaccac cacaggaaag aagtgtcagt cttggtcatc 1320 tatgacacca caccggcacc agaagacccc agaaaactac ccaaatgctg gcctgacaat 1380 gaactactgc aggaatccag atgccgataa aggcccctgg tgttttacca cagaccccag 1440 cgtcaggtgg gagtactgca acctgaaaaa atgctcagga acagaagcga gtgttgtagc 1500 acctccgcct gttgtcctgc ttccagatgt agagactcct tccgaagaag actgtatgtt 1560 tgggaatggg aaaggatacc gaggcaagag ggcgaccact gttactggga cgccatgcca 1620 ggactgggct gcccaggagc cccatagaca cagcattttc actccagaga caaatccacg 1680 ggcgggtctg gaaaaaaatt actgccgtaa ccctgatggt gatgtaggtg gtccctggtg 1740 ctacacgaca aatccaagaa aactttacga ctactgtgat gtccctcagt gtgcggcccc 1800 ttcatttgat tgtgggaagc ctcaagtgga gccgaagaaa tgtcctggaa gggttgtagg 1860 ggggtgtgtg gcccacccac attcctggcc ctggcaagtc agtcttagaa caaggtttgg 1920 aatgcacttc tgtggaggca ccttgatatc cccagagtgg gtgttgactg ctgcccactg 1980 cttggagaag tccccaaggc cttcatccta caaggtcatc ctgggtgcac accaagaagt 2040 gaatctcgaa ccgcatgttc aggaaataga agtgtctagg ctgttcttgg agcccacacg 2100 aaaagatatt gccttgctaa agctaagcag tcctgccgtc atcactgaca aagtaatccc 2160 agcttgtctg ccatccccaa attatgtggt cgctgaccgg accgaatgtt tcatcactgg 2220 ctggggagaa acccaaggta cttttggagc tggccttctc aaggaagccc agctccctgt 2280 gattgagaat aaagtgtgca atcgctatga gtttctgaat ggaagagtcc aatccaccga 2340 actctgtgct gggcatttgg ccggaggcac tgacagttgc cagggtgaca gtggaggtcc 2400 tctggtttgc ttcgagaagg acaaatacat tttacaagga gtcacttctt ggggtcttgg 2460 ctgtgcacgc cccaataagc ctggtgtcta tgttcgtgtt tcaaggtttg ttacttggat 2520 tgagggagtg atgagaaata attaattgga cgggagacag agtgacgcac tgactcacct 2580 agaggctgga acgtgggtag ggatttagca tgctggaaat aactggcagt aatcaaacga 2640 agacactgtc cccagctacc agctacgcca aacctcggca ttttttgtgt tattttctga 2700 ctgctggatt ctgtagtaag gtgacatagc tatgacattt gttaaaaata aactctgtac 2760 ttaactttga tttgagtaaa ttttggtttt ggtcttcaac attttcatgc tctttgttca 2820 ccccaccaat ttttaaatgg gcagatgggg ggatttagct gcttttgata aggaacagct 2880 gcacaaagga ctgagcaggc tgcaaggtca cagaggggag agccaagaag ttgtccacgc 2940 atttacctca tcagctaacg agggcttgac atgcattttt actgtcttta ttcctgacac 3000 tgagatgaat gttttcaaag ctgcaacatg tatggggagt catgcaaacc gattctgtta 3060 ttgggaatga aatctgtcac cgactgcttg acttgagccc aggggacacg gagcagagag 3120 ctgtatatga tggagtgaac cggtccatgg atgtgtaaca caagaccaac tgagagtctg 3180 aatgttattc tggggcacac gtgagtctag gattggtgcc aagagcatgt aaatgaacaa 3240 caagcaaata ttgaaggtgg accacttatt tcccattgct aattgcctgc ccggttttga 3300 aacagtctgc agtacacacg gtcacaggag aatgacctgt gggagagata catgtttaga 3360 aggaagagaa aggacaaagg cacacgtttt accatttaaa atattgttac caaacaaaaa 3420 tatccattca aaatacaatt taacaatgca acagtcatct tacagcagag aaatgcagag 3480 aaaagcaaaa ctgcaagtga ctgtgaataa agggtgaatg tagtctcaaa tcctcaaa 3538 <210> 253 <211> 8718 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(8718) <223> PTEN mRNA <400> 253 cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc 60 ttccgaggcg cccgggctcc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggt 120 gatgtggcgg gactctttat gcgctgcggc aggatacgcg ctcggcgctg ggacgcgact 180 gcgctcagtt ctctcctctc ggaagctgca gccatgatgg aagtttgaga gttgagccgc 240 tgtgaggcga ggccgggctc aggcgaggga gatgagagac ggcggcggcc gcggcccgga 300 gcccctctca gcgcctgtga gcagccgcgg gggcagcgcc ctcggggagc cggccggcct 360 gcggcggcgg cagcggcggc gtttctcgcc tcctcttcgt cttttctaac cgtgcagcct 420 cttcctcggc ttctcctgaa agggaaggtg gaagccgtgg gctcgggcgg gagccggctg 480 aggcgcggcg gcggcggcgg cacctcccgc tcctggagcg ggggggagaa gcggcggcgg 540 cggcggccgc ggcggctgca gctccaggga gggggtctga gtcgcctgtc accatttcca 600 gggctgggaa cgccggagag ttggtctctc cccttctact gcctccaaca cggcggcggc 660 ggcggcggca catccaggga cccgggccgg ttttaaacct cccgtccgcc gccgccgcac 720 cccccgtggc ccgggctccg gaggccgccg gcggaggcag ccgttcggag gattattcgt 780 cttctcccca ttccgctgcc gccgctgcca ggcctctggc tgctgaggag aagcaggccc 840 agtcgctgca accatccagc agccgccgca gcagccatta cccggctgcg gtccagagcc 900 aagcggcggc agagcgaggg gcatcagcta ccgccaagtc cagagccatt tccatcctgc 960 agaagaagcc ccgccaccag cagcttctgc catctctctc ctcctttttc ttcagccaca 1020 ggctcccaga catgacagcc atcatcaaag agatcgttag cagaaacaaa aggagatatc 1080 aagaggatgg attcgactta gacttgacct atatttatcc aaacattatt gctatgggat 1140 ttcctgcaga aagacttgaa ggcgtataca ggaacaatat tgatgatgta gtaaggtttt 1200 tggattcaaa gcataaaaac cattacaaga tatacaatct ttgtgctgaa agacattatg 1260 acaccgccaa atttaattgc agagttgcac aatatccttt tgaagaccat aacccaccac 1320 agctagaact tatcaaaccc ttttgtgaag atcttgacca atggctaagt gaagatgaca 1380 atcatgttgc agcaattcac tgtaaagctg gaaagggacg aactggtgta atgatatgtg 1440 catatttatt acatcggggc aaatttttaa aggcacaaga ggccctagat ttctatgggg 1500 aagtaaggac cagagacaaa aagggagtaa ctattcccag tcagaggcgc tatgtgtatt 1560 attatagcta cctgttaaag aatcatctgg attatagacc agtggcactg ttgtttcaca 1620 agatgatgtt tgaaactatt ccaatgttca gtggcggaac ttgcaatcct cagtttgtgg 1680 tctgccagct aaaggtgaag atatattcct ccaattcagg acccacacga cgggaagaca 1740 agttcatgta ctttgagttc cctcagccgt tacctgtgtg tggtgatatc aaagtagagt 1800 tcttccacaa acagaacaag atgctaaaaa aggacaaaat gtttcacttt tgggtaaata 1860 cattcttcat accaggacca gaggaaacct cagaaaaagt agaaaatgga agtctatgtg 1920 atcaagaaat cgatagcatt tgcagtatag agcgtgcaga taatgacaag gaatatctag 1980 tacttacttt aacaaaaaat gatcttgaca aagcaaataa agacaaagcc aaccgatact 2040 tttctccaaa ttttaaggtg aagctgtact tcacaaaaac agtagaggag ccgtcaaatc 2100 cagaggctag cagttcaact tctgtaacac cagatgttag tgacaatgaa cctgatcatt 2160 atagatattc tgacaccact gactctgatc cagagaatga accttttgat gaagatcagc 2220 atacacaaat tacaaaagtc tgaatttttt tttatcaaga gggataaaac accatgaaaa 2280 taaacttgaa taaactgaaa atggaccttt ttttttttaa tggcaatagg acattgtgtc 2340 agattaccag ttataggaac aattctcttt tcctgaccaa tcttgtttta ccctatacat 2400 ccacagggtt ttgacacttg ttgtccagtt gaaaaaaggt tgtgtagctg tgtcatgtat 2460 ataccttttt gtgtcaaaag gacatttaaa attcaattag gattaataaa gatggcactt 2520 tcccgtttta ttccagtttt ataaaaagtg gagacagact gatgtgtata cgtaggaatt 2580 ttttcctttt gtgttctgtc accaactgaa gtggctaaag agctttgtga tatactggtt 2640 cacatcctac ccctttgcac ttgtggcaac agataagttt gcagttggct aagagaggtt 2700 tccgaagggt tttgctacat tctaatgcat gtattcgggt taggggaatg gagggaatgc 2760 tcagaaagga aataatttta tgctggactc tggaccatat accatctcca gctatttaca 2820 cacacctttc tttagcatgc tacagttatt aatctggaca ttcgaggaat tggccgctgt 2880 cactgcttgt tgtttgcgca ttttttttta aagcatattg gtgctagaaa aggcagctaa 2940 aggaagtgaa tctgtattgg ggtacaggaa tgaaccttct gcaacatctt aagatccaca 3000 aatgaaggga tataaaaata atgtcatagg taagaaacac agcaacaatg acttaaccat 3060 ataaatgtgg aggctatcaa caaagaatgg gcttgaaaca ttataaaaat tgacaatgat 3120 ttattaaata tgttttctca attgtaacga cttctccatc tcctgtgtaa tcaaggccag 3180 tgctaaaatt cagatgctgt tagtacctac atcagtcaac aacttacact tattttacta 3240 gttttcaatc ataatacctg ctgtggatgc ttcatgtgct gcctgcaagc ttcttttttc 3300 tcattaaata taaaatattt tgtaatgctg cacagaaatt ttcaatttga gattctacag 3360 taagcgtttt ttttctttga agatttatga tgcacttatt caatagctgt cagccgttcc 3420 acccttttga ccttacacat tctattacaa tgaattttgc agttttgcac attttttaaa 3480 tgtcattaac tgttagggaa ttttacttga atactgaata catataatgt ttatattaaa 3540 aaggacattt gtgttaaaaa ggaaattaga gttgcagtaa actttcaatg ctgcacacaa 3600 aaaaaagaca tttgattttt cagtagaaat tgtcctacat gtgctttatt gatttgctat 3660 tgaaagaata gggttttttt tttttttttt tttttttttt ttaaatgtgc agtgttgaat 3720 catttcttca tagtgctccc ccgagttggg actagggctt caatttcact tcttaaaaaa 3780 aatcatcata tatttgatat gcccagactg catacgattt taagcggagt acaactacta 3840 ttgtaaagct aatgtgaaga tattattaaa aaggtttttt tttccagaaa tttggtgtct 3900 tcaaattata ccttcacctt gacatttgaa tatccagcca ttttgtttct taatggtata 3960 aaattccatt ttcaataact tattggtgct gaaattgttc actagctgtg gtctgaccta 4020 gttaatttac aaatacagat tgaataggac ctactagagc agcatttata gagtttgatg 4080 gcaaatagat taggcagaac ttcatctaaa atattcttag taaataatgt tgacacgttt 4140 tccatacctt gtcagtttca ttcaacaatt tttaaatttt taacaaagct cttaggattt 4200 acacatttat atttaaacat tgatatatag agtattgatt gattgctcat aagttaaatt 4260 ggtaaagtta gagacaacta ttctaacacc tcaccattga aatttatatg ccaccttgtc 4320 tttcataaaa gctgaaaatt gttacctaaa atgaaaatca acttcatgtt ttgaagatag 4380 ttataaatat tgttctttgt tacaatttcg ggcaccgcat attaaaacgt aactttattg 4440 ttccaatatg taacatggag ggccaggtca taaataatga cattataatg ggcttttgca 4500 ctgttattat ttttcctttg gaatgtgaag gtctgaatga gggttttgat tttgaatgtt 4560 tcaatgtttt tgagaagcct tgcttacatt ttatggtgta gtcattggaa atggaaaaat 4620 ggcattatat atattatata tataaatata tattatacat actctcctta ctttatttca 4680 gttaccatcc ccatagaatt tgacaagaat tgctatgact gaaaggtttt cgagtcctaa 4740 ttaaaacttt atttatggca gtattcataa ttagcctgaa atgcattctg taggtaatct 4800 ctgagtttct ggaatatttt cttagacttt ttggatgtgc agcagcttac atgtctgaag 4860 ttacttgaag gcatcacttt taagaaagct tacagttggg ccctgtacca tcccaagtcc 4920 tttgtagctc ctcttgaaca tgtttgccat acttttaaaa gggtagttga ataaatagca 4980 tcaccattct ttgctgtggc acaggttata aacttaagtg gagtttaccg gcagcatcaa 5040 atgtttcagc tttaaaaaat aaaagtaggg tacaagttta atgtttagtt ctagaaattt 5100 tgtgcaatat gttcataacg atggctgtgg ttgccacaaa gtgcctcgtt tacctttaaa 5160 tactgttaat gtgtcatgca tgcagatgga aggggtggaa ctgtgcacta aagtgggggc 5220 tttaactgta gtatttggca gagttgcctt ctacctgcca gttcaaaagt tcaacctgtt 5280 ttcatataga atatatatac taaaaaattt cagtctgtta aacagcctta ctctgattca 5340 gcctcttcag atactcttgt gctgtgcagc agtggctctg tgtgtaaatg ctatgcactg 5400 aggatacaca aaaataccaa tatgatgtgt acaggataat gcctcatccc aatcagatgt 5460 ccatttgtta ttgtgtttgt taacaaccct ttatctctta gtgttataaa ctccacttaa 5520 aactgattaa agtctcattc ttgtcattgt gtgggtgttt tattaaatga gagtttataa 5580 ttcaaattgc ttaagtccat tgaagtttta attaatgggc agccaaatgt gaatacaaag 5640 ttttcagttt ttttttttcc tgctgtcctt caaagcctac tgtttaaaaa aaaaaaaaaa 5700 aaaaaacatg gcctgagagt agagtatctg tctactcatg tttaattaag gaaaaacact 5760 tatttttagg gctttagtca tcacttcata aattgtataa gcacattaaa tagcgttcta 5820 gtcctgaaaa agtccaagat tcttagaaaa ttgtgcatat ttttattatg acagatgttt 5880 gaagataatt ccccagaatg gatttgatac tttagatttc aattttgtgg cttttgtcta 5940 ttattctgta ctctgccatc agcatatgga aagcttcatt tactcatcat gacttgtgcc 6000 atataaaaat tgatatttcg gaatagtcta aaggactttt tgtacttgaa tttaatcatg 6060 ttgtttctaa tattcttaaa agcttgaaga ctaaagcata tcctttcaac aaagcatagt 6120 aaggtaataa gaaagtgtag tttgtacaag tgttaaaaaa ataaagtaga caatgttaca 6180 gtgggactta ttatttcaag tttacatttt ctccatgtaa ttttttaaaa agtaaatgaa 6240 aaaatgtgca ataatgtaaa atatgaagtg tatgtgtaca cacattttat ttttcggtat 6300 cttgggtata cgtatggttg aaaactatac tggagtctaa aagtattcta atttataaga 6360 agacattttg gtgatgtttg aaaaatagaa atgtgctagt tttgttttta tatcatgtcc 6420 tttgtacgtt gtaatatgag ctggcttggt tcagtaaatg ccatcaccat ttccattgag 6480 aatttaaaac tcaccagtgt ttaatatgca ggcttccaaa ggcttatgaa aaaaatcaag 6540 acccttaaat ctagttaatt tgctgctaac atgaaactct ttggttcttt tatttttgcc 6600 agataattag acacacatct aaagcttagt cttaaatggc ttaagtgtag ctattgatta 6660 gtgctgttgc tagttcagaa agaaatgttt gtgaatggaa acaagaatat tcagtccaaa 6720 ctgttgtaag gacagtacct gaaaaccagg aaacaggata atggaaaaag tcttttaaag 6780 atgaaatgtt ggagccaact ttcttataga attaattgta tgtggctata gaaagcctaa 6840 tgattgttgc ttatttttga gagcatatta ttcttttatg accataatct tgctgttttt 6900 ccatcttcca aaagatcttc cttctaatat gtatatcaga atgtgggtag ccagtcagac 6960 aaattcatat tggttggtag ctttaaaaag tttgtaatgt gaagacagga aaggacaaaa 7020 tagtttgctt tggtggtagt actctggttg ttaagctagg tattttgaga ctacttcccc 7080 atcacaacaa caataaaata atcactcata atcctatcac ctggagacat agccatcgtt 7140 aatatgttag tgactataca atcatgtttt cttctgtata tccatgtata ttctttaaaa 7200 atgaaattta tactgtacct gatctcaaag ctttttagct tagtatatct gtcatgaatt 7260 tgtaggatgt tccattgcat cagaaaacgg acagtgattt gattactttc taatgccaca 7320 gatgcagatt acatgtagtt attgagaatc ctttcgaatt cagtggctta atcatgaatg 7380 tctaaatatt gttgacatta ggatgataca tgtaaattaa agttacattt gtttagcata 7440 gacaagctta acattgtaga tgtttctctt caaaaatcat cttaaacatt tgcatttgga 7500 attgtgttaa atagaatgtg tgaaacactg tattagtaaa cttcatcacc tttctacttc 7560 cttatagttt gaacttttca gtttttgtag ttcccaaaca gttgctcaat ttagagcaaa 7620 ttaatttaac acctgccaaa aaaaggctgc tgttggctta tcagttgtct ttaaattcaa 7680 atgctcatgt gacttttatc acatcaaaaa atatttcatt aatgattcac ctttagctct 7740 gaaaattacc gcgtttagta attatagtgg gcttataaaa acatgcaact ctttttgata 7800 gttatttgag aattttggtg aaaaatattt agctgagggc agtatagaac ttataaacca 7860 atatattgat atttttaaaa catttttaca tataagtaaa ctgccatctt tgagcataac 7920 tacatttaaa aataaagctg catattttta aatcaagtgt ttaacaagaa tttatatttt 7980 ttatttttta aaattaaaaa taatttatat ttcctctgtt gcatgaggat tctcatctgt 8040 gcttataatg gttagagatt ttatttgtgt ggaatgaagt gaggcttgta gtcatggttc 8100 tagtgtttca gtttgccaag tctgtttact gcagtgaaat tcatcaaatg tttcagtgtg 8160 gttttctgta gcctatcatt tactggctat ttttttatgt acacctttag gattttctgc 8220 ctactctatc cagttgtcca aatgatatcc tacattttac aaatgccctt tcagtttcta 8280 ttttcttttt ccattaaatt gccctcatgt cctaatgtgc agtttgtaag tgtgtgtgtg 8340 tgtgtctgtg tgtgtgtgaa tttgattttc aagagtgcta gacttccaat ttgagagatt 8400 aaataattta attcaggcaa acatttttca ttggaatttc acagttcatt gtaatgaaaa 8460 tgttaatcct ggatgacctt tgacatacag taatgaatct tggatattaa tgaatttgtt 8520 agtagcatct tgatgtgtgt tttaatgagt tattttcaaa gttgtgcatt aaaccaaagt 8580 tggcatactg gaagtgttta tatcaagttc catttggcta ctgatggaca aaaaatagaa 8640 atgccttcct atggagagta tttttccttt aaaaaattaa aaaggttaat tattttgact 8700 aaaaaaaaaa aaaaaaaa 8718 <210> 254 <211> 4510 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4510) <223> PTGS2 mRNA <400> 254 aattgtcata cgacttgcag tgagcgtcag gagcacgtcc aggaactcct cagcagcgcc 60 tccttcagct ccacagccag acgccctcag acagcaaagc ctacccccgc gccgcgccct 120 gcccgccgct gcgatgctcg cccgcgccct gctgctgtgc gcggtcctgg cgctcagcca 180 tacagcaaat ccttgctgtt cccacccatg tcaaaaccga ggtgtatgta tgagtgtggg 240 atttgaccag tataagtgcg attgtacccg gacaggattc tatggagaaa actgctcaac 300 accggaattt ttgacaagaa taaaattatt tctgaaaccc actccaaaca cagtgcacta 360 catacttacc cacttcaagg gattttggaa cgttgtgaat aacattccct tccttcgaaa 420 tgcaattatg agttatgtgt tgacatccag atcacatttg attgacagtc caccaactta 480 caatgctgac tatggctaca aaagctggga agccttctct aacctctcct attatactag 540 agcccttcct cctgtgcctg atgattgccc gactcccttg ggtgtcaaag gtaaaaagca 600 gcttcctgat tcaaatgaga ttgtggaaaa attgcttcta agaagaaagt tcatccctga 660 tccccagggc tcaaacatga tgtttgcatt ctttgcccag cacttcacgc atcagttttt 720 caagacagat cataagcgag ggccagcttt caccaacggg ctgggccatg gggtggactt 780 aaatcatatt tacggtgaaa ctctggctag acagcgtaaa ctgcgccttt tcaaggatgg 840 aaaaatgaaa tatcagataa ttgatggaga gatgtatcct cccacagtca aagatactca 900 ggcagagatg atctaccctc ctcaagtccc tgagcatcta cggtttgctg tggggcagga 960 ggtctttggt ctggtgcctg gtctgatgat gtatgccaca atctggctgc gggaacacaa 1020 cagagtatgc gatgtgctta aacaggagca tcctgaatgg ggtgatgagc agttgttcca 1080 gacaagcagg ctaatactga taggagagac tattaagatt gtgattgaag attatgtgca 1140 acacttgagt ggctatcact tcaaactgaa atttgaccca gaactacttt tcaacaaaca 1200 attccagtac caaaatcgta ttgctgctga atttaacacc ctctatcact ggcatcccct 1260 tctgcctgac acctttcaaa ttcatgacca gaaatacaac tatcaacagt ttatctacaa 1320 caactctata ttgctggaac atggaattac ccagtttgtt gaatcattca ccaggcaaat 1380 tgctggcagg gttgctggtg gtaggaatgt tccacccgca gtacagaaag tatcacaggc 1440 ttccattgac cagagcaggc agatgaaata ccagtctttt aatgagtacc gcaaacgctt 1500 tatgctgaag ccctatgaat catttgaaga acttacagga gaaaaggaaa tgtctgcaga 1560 gttggaagca ctctatggtg acatcgatgc tgtggagctg tatcctgccc ttctggtaga 1620 aaagcctcgg ccagatgcca tctttggtga aaccatggta gaagttggag caccattctc 1680 cttgaaagga cttatgggta atgttatatg ttctcctgcc tactggaagc caagcacttt 1740 tggtggagaa gtgggttttc aaatcatcaa cactgcctca attcagtctc tcatctgcaa 1800 taacgtgaag ggctgtccct ttacttcatt cagtgttcca gatccagagc tcattaaaac 1860 agtcaccatc aatgcaagtt cttcccgctc cggactagat gatatcaatc ccacagtact 1920 actaaaagaa cgttcgactg aactgtagaa gtctaatgat catatttatt tatttatatg 1980 aaccatgtct attaatttaa ttatttaata atatttatat taaactcctt atgttactta 2040 acatcttctg taacagaagt cagtactcct gttgcggaga aaggagtcat acttgtgaag 2100 acttttatgt cactactcta aagattttgc tgttgctgtt aagtttggaa aacagttttt 2160 attctgtttt ataaaccaga gagaaatgag ttttgacgtc tttttacttg aatttcaact 2220 tatattataa gaacgaaagt aaagatgttt gaatacttaa acactgtcac aagatggcaa 2280 aatgctgaaa gtttttacac tgtcgatgtt tccaatgcat cttccatgat gcattagaag 2340 taactaatgt ttgaaatttt aaagtacttt tggttatttt tctgtcatca aacaaaaaca 2400 ggtatcagtg cattattaaa tgaatattta aattagacat taccagtaat ttcatgtcta 2460 ctttttaaaa tcagcaatga aacaataatt tgaaatttct aaattcatag ggtagaatca 2520 cctgtaaaag cttgtttgat ttcttaaagt tattaaactt gtacatatac caaaaagaag 2580 ctgtcttgga tttaaatctg taaaatcagt agaaatttta ctacaattgc ttgttaaaat 2640 attttataag tgatgttcct ttttcaccaa gagtataaac ctttttagtg tgactgttaa 2700 aacttccttt taaatcaaaa tgccaaattt attaaggtgg tggagccact gcagtgttat 2760 cttaaaataa gaatattttg ttgagatatt ccagaatttg tttatatggc tggtaacatg 2820 taaaatctat atcagcaaaa gggtctacct ttaaaataag caataacaaa gaagaaaacc 2880 aaattattgt tcaaatttag gtttaaactt ttgaagcaaa ctttttttta tccttgtgca 2940 ctgcaggcct ggtactcaga ttttgctatg aggttaatga agtaccaagc tgtgcttgaa 3000 taatgatatg ttttctcaga ttttctgttg tacagtttaa tttagcagtc catatcacat 3060 tgcaaaagta gcaatgacct cataaaatac ctcttcaaaa tgcttaaatt catttcacac 3120 attaatttta tctcagtctt gaagccaatt cagtaggtgc attggaatca agcctggcta 3180 cctgcatgct gttccttttc ttttcttctt ttagccattt tgctaagaga cacagtcttc 3240 tcatcacttc gtttctccta ttttgtttta ctagttttaa gatcagagtt cactttcttt 3300 ggactctgcc tatattttct tacctgaact tttgcaagtt ttcaggtaaa cctcagctca 3360 ggactgctat ttagctcctc ttaagaagat taaaagagaa aaaaaaaggc ccttttaaaa 3420 atagtataca cttattttaa gtgaaaagca gagaatttta tttatagcta attttagcta 3480 tctgtaacca agatggatgc aaagaggcta gtgcctcaga gagaactgta cggggtttgt 3540 gactggaaaa agttacgttc ccattctaat taatgccctt tcttatttaa aaacaaaacc 3600 aaatgatatc taagtagttc tcagcaataa taataatgac gataatactt cttttccaca 3660 tctcattgtc actgacattt aatggtactg tatattactt aatttattga agattattat 3720 ttatgtctta ttaggacact atggttataa actgtgttta agcctacaat cattgatttt 3780 tttttgttat gtcacaatca gtatattttc tttggggtta cctctctgaa tattatgtaa 3840 acaatccaaa gaaatgattg tattaagatt tgtgaataaa tttttagaaa tctgattggc 3900 atattgagat atttaaggtt gaatgtttgt ccttaggata ggcctatgtg ctagcccaca 3960 aagaatattg tctcattagc ctgaatgtgc cataagactg accttttaaa atgttttgag 4020 ggatctgtgg atgcttcgtt aatttgttca gccacaattt attgagaaaa tattctgtgt 4080 caagcactgt gggttttaat atttttaaat caaacgctga ttacagataa tagtatttat 4140 ataaataatt gaaaaaaatt ttcttttggg aagagggaga aaatgaaata aatatcatta 4200 aagataactc aggagaatct tctttacaat tttacgttta gaatgtttaa ggttaagaaa 4260 gaaatagtca atatgcttgt ataaaacact gttcactgtt ttttttaaaa aaaaaacttg 4320 atttgttatt aacattgatc tgctgacaaa acctgggaat ttgggttgtg tatgcgaatg 4380 tttcagtgcc tcagacaaat gtgtatttaa cttatgtaaa agataagtct ggaaataaat 4440 gtctgtttat ttttgtacta tttaaaaatt gacagatctt ttctgaagat aaactttgat 4500 tgtttctata 4510 <210> 255 <211> 1884 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1884) <223> PTX3 mRNA <400> 255 actctcactc tcctccgctc aaactcagct cacttgagag tctcctcccg ccagctgtgg 60 aaagaacttt gcgtctctcc agcaatgcat ctccttgcga ttctgttttg tgctctctgg 120 tctgcagtgt tggccgagaa ctcggatgat tatgatctca tgtatgtgaa tttggacaac 180 gaaatagaca atggactcca tcccactgag gaccccacgc cgtgcgcctg cggtcaggag 240 cactcggaat gggacaagct cttcatcatg ctggagaact cgcagatgag agagcgcatg 300 ctgctgcaag ccacggacga cgtcctgcgg ggcgagctgc agaggctgcg ggaggagctg 360 ggccggctcg cggaaagcct ggcgaggccg tgcgcgccgg gggctcccgc agaggccagg 420 ctgaccagtg ctctggacga gctgctgcag gcgacccgcg acgcgggccg caggctggcg 480 cgtatggagg gcgcggaggc gcagcgccca gaggaggcgg ggcgcgccct ggccgcggtg 540 ctagaggagc tgcggcagac gcgagccgac ctgcacgcgg tgcagggctg ggctgcccgg 600 agctggctgc cggcaggttg tgaaacagct attttattcc caatgcgttc caagaagatt 660 tttggaagcg tgcatccagt gagaccaatg aggcttgagt cttttagtgc ctgcatttgg 720 gtcaaagcca cagatgtatt aaacaaaacc atcctgtttt cctatggcac aaagaggaat 780 ccatatgaaa tccagctgta tctcagctac caatccatag tgtttgtggt gggtggagag 840 gagaacaaac tggttgctga agccatggtt tccctgggaa ggtggaccca cctgtgcggc 900 acctggaatt cagaggaagg gctcacatcc ttgtgggtaa atggtgaact ggcggctacc 960 actgttgaga tggccacagg tcacattgtt cctgagggag gaatcctgca gattggccaa 1020 gaaaagaatg gctgctgtgt gggtggtggc tttgatgaaa cattagcctt ctctgggaga 1080 ctcacaggct tcaatatctg ggatagtgtt cttagcaatg aagagataag agagaccgga 1140 ggagcagagt cttgtcacat ccgggggaat attgttgggt ggggagtcac agagatccag 1200 ccacatggag gagctcagta tgtttcataa atgttgtgaa actccacttg aagccaaaga 1260 aagaaactca cacttaaaac acatgccagt tgggaaggtc tgaaaactca gtgcataata 1320 ggaacacttg agactaatga aagagagagt tgagaccaat ctttatttgt actggccaaa 1380 tactgaataa acagttgaag gaaagacatt ggaaaaagct tttgaggata atgttactag 1440 actttatgcc atggtgcttt cagtttaatg ctgtgtctct gtcagataaa ctctcaaata 1500 attaaaaagg actgtattgt tgaacagagg gacaattgtt ttacttttct ttggttaatt 1560 ttgttttggc cagagatgaa ttttacattg gaagaataac aaaataagat ttgttgtcca 1620 ttgttcattg ttattggtat gtaccttatt acaaaaaaaa gatgaaaaca tatttatact 1680 acaaggtgac ttaacaacta taaatgtagt ttatgtgtta taatcgaatg tcacgttttt 1740 gagaagatag tcatataagt tatattgcaa aagggatttg tattaattta agactatttt 1800 tgtaaagctc tactgtaaat aaaatatttt ataaaactag ctcacgtcat ttaattataa 1860 atttaagaga tgttttggag caaa 1884 <210> 256 <211> 2398 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2398) <223> RAC1 mRNA <400> 256 gggaggccgg atgtgagtgg agcggccatt tcctgtttct ctgcagtttt cctcagcttt 60 gggtggtggc cgctgccggg catcggcttc cagtccgcgg agggcgaggc ggcgtggaca 120 gcggccccgg cacccagcgc cccgccgccc gcaagccgcg cgcccgtccg ccgcgccccg 180 agcccgccgc ttcctatctc agcgccctgc cgccgccgcc gcggcccagc gagcggccct 240 gatgcaggcc atcaagtgtg tggtggtggg agacggagct gtaggtaaaa cttgcctact 300 gatcagttac acaaccaatg catttcctgg agaatatatc cctactgtct ttgacaatta 360 ttctgccaat gttatggtag atggaaaacc ggtgaatctg ggcttatggg atacagctgg 420 acaagaagat tatgacagat tacgccccct atcctatccg caaacagttg gagaaacgta 480 cggtaaggat ataacctccc ggggcaaaga caagccgatt gccgatgtgt tcttaatttg 540 cttttccctt gtgagtcctg catcatttga aaatgtccgt gcaaagtggt atcctgaggt 600 gcggcaccac tgtcccaaca ctcccatcat cctagtggga actaaacttg atcttaggga 660 tgataaagac acgatcgaga aactgaagga gaagaagctg actcccatca cctatccgca 720 gggtctagcc atggctaagg agattggtgc tgtaaaatac ctggagtgct cggcgctcac 780 acagcgaggc ctcaagacag tgtttgacga agcgatccga gcagtcctct gcccgcctcc 840 cgtgaagaag aggaagagaa aatgcctgct gttgtaaatg tctcagcccc tcgttcttgg 900 tcctgtccct tggaaccttt gtacgctttg ctcaaaaaaa aacaaaaaaa aaaaacaaaa 960 aaaaaaaaca acggtggagc cttcgcactc aatgccaact ttttgttaca gattaatttt 1020 tccataaaac cattttttga accaatcagt aattttaagg ttttgtttgt tctaaatgta 1080 agagttcaga ctcacattct attaaaattt agccctaaaa tgacaagcct tcttaaagcc 1140 ttatttttca aaagcgcccc ccccattctt gttcagatta agagttgcca aaataccttc 1200 tgaactacac tgcattgttg tgccgagaac accgagcact gaactttgca aagaccttcg 1260 tctttgagaa gacggtagct tctgcagtta ggaggtgcag acacttgctc tcctatgtag 1320 ttctcagatg cgtaaagcag aacagcctcc cgaatgaagc gttgccattg aactcaccag 1380 tgagttagca gcacgtgttc ccgacataac attgtactgt aatggagtga gcgtagcagc 1440 tcagctcttt ggatcagtct ttgtgatttc atagcgagtt ttctgaccag cttttgcgga 1500 gattttgaac agaactgcta tttcctctaa tgaagaattc tgtttagctg tgggtgtgcc 1560 gggtggggtg tgtgtgatca aaggacaaag acagtatttt gacaaaatac gaagtggaga 1620 tttacactac attgtacaag gaatgaaagt gtcacgggta aaaactctaa aaggttaatt 1680 tctgtcaaat gcagtagatg atgaaagaaa ggttggtatt atcaggaaat gttttcttaa 1740 gcttttcctt tctcttacac ctgccatgcc tccccaaatt gggcatttaa ttcatcttta 1800 aactggttgt tctgttagtc gctaacttag taagtgcttt tcttatagaa ccccttctga 1860 ctgagcaata tgcctccttg tattataaaa tctttctgat aatgcattag aaggtttttt 1920 tgtcgattag taaaagtgct ttccatgtta ctttattcag agctaataag tgctttcctt 1980 agttttctag taactaggtg taaaaatcat gtgttgcagc tttatagttt ttaaaatatt 2040 ttagataatt cttaaactat gaaccttctt aacatcactg tcttgccaga ttaccgacac 2100 tgtcacttga ccaatactga ccctctttac ctcgcccacg cggacacacg cctcctgtag 2160 tcgctttgcc tattgatgtt cctttgggtc tgtgaggttc tgtaaactgt gctagtgctg 2220 acgatgttct gtacaactta actcactggc gagaatacag cgtgggaccc ttcagccact 2280 acaacagaat tttttaaatt gacagttgca gaattgtgga gtgtttttac attgatcttt 2340 tgctaatgca attagcatta tgttttgcat gtatgactta ataaatcctt gaatcata 2398 <210> 257 <211> 1943 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1943) <223> RHOA mRNA <400> 257 aatagtggat gagctgtgag tgcgcgcgcg tgcgcggggc cgcgacctgt gccggctcga 60 gcccgctggg cactcggagg cgcgcacgtc gttccccgcc ctcccgccgc cgcccgccct 120 cgctctctcg cgctaccctc ccgccgcccg cggtcctccg tcggttctct cgttagtcca 180 cggtctggtc ttcagctacc cgccttcgtc tccgagtttg cgactcgcgg accggcgtcc 240 ccggcgcgaa gaggctggac tcggattcgt tgcctgagca atggctgcca tccggaagaa 300 actggtgatt gttggtgatg gagcctgtgg aaagacatgc ttgctcatag tcttcagcaa 360 ggaccagttc ccagaggtgt atgtgcccac agtgtttgag aactatgtgg cagatatcga 420 ggtggatgga aagcaggtag agttggcttt gtgggacaca gctgggcagg aagattatga 480 tcgcctgagg cccctctcct acccagatac cgatgttata ctgatgtgtt tttccatcga 540 cagccctgat agtttagaaa acatcccaga aaagtggacc ccagaagtca agcatttctg 600 tcccaacgtg cccatcatcc tggttgggaa taagaaggat cttcggaatg atgagcacac 660 aaggcgggag ctagccaaga tgaagcagga gccggtgaaa cctgaagaag gcagagatat 720 ggcaaacagg attggcgctt ttgggtacat ggagtgttca gcaaagacca aagatggagt 780 gagagaggtt tttgaaatgg ctacgagagc tgctctgcaa gctagacgtg ggaagaaaaa 840 atctgggtgc cttgtcttgt gaaaccttgc tgcaagcaca gcccttatgc ggttaatttt 900 gaagtgctgt ttattaatct tagtgtatga ttactggcct ttttcattta tctataattt 960 acctaagatt acaaatcaga agtcatcttg ctaccagtat ttagaagcca actatgatta 1020 ttaacgatgt ccaacccgtc tggcccacca gggtcctttt gacactgctc taacagccct 1080 cctctgcact cccacctgac acaccaggcg ctaattcaag gaatttctta acttcttgct 1140 tctttctaga aagagaaaca gttggtaact tttgtgaatt aggctgtaac tactttataa 1200 ctaacatgtc ctgcctatta tctgtcagct gcaaggtact ctggtgagtc accacttcag 1260 ggctttactc cgtaacagat tttgttggca tagctctggg gtgggcagtt ttttgaaaat 1320 gggctcaacc agaaaagccc aagttcatgc agctgtggca gagttacagt tctgtggttt 1380 catgttagtt accttatagt tactgtgtaa ttagtgccac ttaatgtatg ttaccaaaaa 1440 taaatatatc taccccagac tagatgtagt attttttgta taattggatt tcctaatact 1500 gtcatcctca aagaaagtgt attggttttt taaaaaagaa agtgtatttg gaaataaagt 1560 cagatggaaa attcattttt taaattcccg ttttgtcact ttttctgata aaagatggcc 1620 atattacccc ttttcggccc catgtatctc agtaccccat ggagctgggc taagtaaata 1680 ggaattggtt tcacgcctga ggcaattaga cactttggaa gatggcataa cctgtctcac 1740 ctggacttaa gcatctggct ctaattcaca gtgctctttt ctcctcactg tatccaggtt 1800 ccctcccaga ggagccacca gttctcatgg gtggcactca gtctctcttc tctccagctg 1860 actaaacttt ttttctgtac cagttaattt ttccaactac taatagaata aaggcagttt 1920 tctaaacttc ctgtaaaaaa aaa 1943 <210> 258 <211> 3207 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3207) <223> SERPINB2 mRNA <400> 258 ggcccacaga ggagcacagc tgtgtttggc tgcagggcca agagcgctgt caagaagacc 60 cacacgcccc cctccagcag ctgaattcct gcagctcagc agccgccgcc agagcaggac 120 gaaccgccaa tcgcaaggca cctctgagaa cttcaggatg cagatgtctc cagccctcac 180 ctgcctagtc ctgggcctgg cccttgtctt tggtgaaggg tctgctgtgc accatccccc 240 atcctacgtg gcccacctgg cctcagactt cggggtgagg gtgtttcagc aggtggcgca 300 ggcctccaag gaccgcaacg tggttttctc accctatggg gtggcctcgg tgttggccat 360 gctccagctg acaacaggag gagaaaccca gcagcagatt caagcagcta tgggattcaa 420 gattgatgac aagggcatgg cccccgccct ccggcatctg tacaaggagc tcatggggcc 480 atggaacaag gatgagatca gcaccacaga cgcgatcttc gtccagcggg atctgaagct 540 ggtccagggc ttcatgcccc acttcttcag gctgttccgg agcacggtca agcaagtgga 600 cttttcagag gtggagagag ccagattcat catcaatgac tgggtgaaga cacacacaaa 660 aggtatgatc agcaacttgc ttgggaaagg agccgtggac cagctgacac ggctggtgct 720 ggtgaatgcc ctctacttca acggccagtg gaagactccc ttccccgact ccagcaccca 780 ccgccgcctc ttccacaaat cagacggcag cactgtctct gtgcccatga tggctcagac 840 caacaagttc aactatactg agttcaccac gcccgatggc cattactacg acatcctgga 900 actgccctac cacggggaca ccctcagcat gttcattgct gccccttatg aaaaagaggt 960 gcctctctct gccctcacca acattctgag tgcccagctc atcagccact ggaaaggcaa 1020 catgaccagg ctgccccgcc tcctggttct gcccaagttc tccctggaga ctgaagtcga 1080 cctcaggaag cccctagaga acctgggaat gaccgacatg ttcagacagt ttcaggctga 1140 cttcacgagt ctttcagacc aagagcctct ccacgtcgcg caggcgctgc agaaagtgaa 1200 gatcgaggtg aacgagagtg gcacggtggc ctcctcatcc acagctgtca tagtctcagc 1260 ccgcatggcc cccgaggaga tcatcatgga cagacccttc ctctttgtgg tccggcacaa 1320 ccccacagga acagtccttt tcatgggcca agtgatggaa ccctgaccct ggggaaagac 1380 gccttcatct gggacaaaac tggagatgca tcgggaaaga agaaactccg aagaaaagaa 1440 ttttagtgtt aatgactctt tctgaaggaa gagaagacat ttgccttttg ttaaaagatg 1500 gtaaaccaga tctgtctcca agaccttggc ctctccttgg aggaccttta ggtcaaactc 1560 cctagtctcc acctgagacc ctgggagaga agtttgaagc acaactccct taaggtctcc 1620 aaaccagacg gtgacgcctg cgggaccatc tggggcacct gcttccaccc gtctctctgc 1680 ccactcgggt ctgcagacct ggttcccact gaggcccttt gcaggatgga actacggggc 1740 ttacaggagc ttttgtgtgc ctggtagaaa ctatttctgt tccagtcaca ttgccatcac 1800 tcttgtactg cctgccaccg cggaggaggc tggtgacagg ccaaaggcca gtggaagaaa 1860 caccctttca tctcagagtc cactgtggca ctggccaccc ctccccagta caggggtgct 1920 gcaggtggca gagtgaatgt cccccatcat gtggcccaac tctcctggcc tggccatctc 1980 cctccccaga aacagtgtgc atgggttatt ttggagtgta ggtgacttgt ttactcattg 2040 aagcagattt ctgcttcctt ttatttttat aggaatagag gaagaaatgt cagatgcgtg 2100 cccagctctt caccccccaa tctcttggtg gggaggggtg tacctaaata tttatcatat 2160 ccttgccctt gagtgcttgt tagagagaaa gagaactact aaggaaaata atattattta 2220 aactcgctcc tagtgtttct ttgtggtctg tgtcaccgta tctcaggaag tccagccact 2280 tgactggcac acacccctcc ggacatccag cgtgacggag cccacactgc caccttgtgg 2340 ccgcctgaga ccctcgcgcc ccccgcgccc ctctttttcc ccttgatgga aattgaccat 2400 acaatttcat cctccttcag gggatcaaaa ggacggagtg gggggacaga gactcagatg 2460 aggacagagt ggtttccaat gtgttcaata gatttaggag cagaaatgca aggggctgca 2520 tgacctacca ggacagaact ttccccaatt acagggtgac tcacagccgc attggtgact 2580 cacttcaatg tgtcatttcc ggctgctgtg tgtgagcagt ggacacgtga ggggggggtg 2640 ggtgagagag acaggcagct cggattcaac taccttagat aatatttctg aaaacctacc 2700 agccagaggg tagggcacaa agatggatgt aatgcacttt gggaggccaa ggcgggagga 2760 ttgcttgagc ccaggagttc aagaccagcc tgggcaacat accaagaccc ccgtctcttt 2820 aaaaatatat atattttaaa tatacttaaa tatatatttc taatatcttt aaatatatat 2880 atatatttta aagaccaatt tatgggagaa ttgcacacag atgtgaaatg aatgtaatct 2940 aatagaagcc taatcagccc accatgttct ccactgaaaa atcctctttc tttggggttt 3000 ttctttcttt cttttttgat tttgcactgg acggtgacgt cagccatgta caggatccac 3060 aggggtggtg tcaaatgcta ttgaaattgt gttgaattgt atgctttttc acttttgata 3120 aataaacatg taaaaatgtt tcaaaaaaat aataaaataa ataaatacga agaatatgtc 3180 aggacagtca aaaaaaaaaa aaaaaaa 3207 <210> 259 <211> 2180 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2180) <223> SERPINE1 mRNA <400> 259 gtaacaactc tcagaggagc attgcccgtc agacagcaac tcagagaata accagagaac 60 aaccagcatt tcttgcacta caacttgctt aagctcttac acttcatagt gaagctatgc 120 accaccgagt gaagcgatgt ggaacattgg aaagagtggg cttccttaga cagacctggg 180 cttgaatccc tgctccacta cctaccagct gtgtgacctt atacaagtta cttaatgttt 240 ctgagcatca ggatataatc tataaaatag ggagaatcac ctctacctca tacagattct 300 gcaaagatta aacgaggaga ggagattgaa acaatggagg atctttgtgt ggcaaacaca 360 ctctttgccc tcaatttatt caagcatctg gcaaaagcaa gccccaccca gaacctcttc 420 ctctccccat ggagcatctc gtccaccatg gccatggtct acatgggctc caggggcagc 480 accgaagacc agatggccaa ggtgcttcag tttaatgaag tgggagccaa tgcagttacc 540 cccatgactc cagagaactt taccagctgt gggttcatgc agcagatcca gaagggtagt 600 tatcctgatg cgattttgca ggcacaagct gcagataaaa tccattcatc cttccgctct 660 ctcagctctg caatcaatgc atccacaggg aattatttac tggaaagtgt caataagctg 720 tttggtgaga agtctgcgag cttccgggaa gaatatattc gactctgtca gaaatattac 780 tcctcagaac cccaggcagt agacttccta gaatgtgcag aagaagctag aaaaaagatt 840 aattcctggg tcaagactca aaccaaaggc aaaatcccaa acttgttacc tgaaggttct 900 gtagatgggg ataccaggat ggtcctggtg aatgctgtct acttcaaagg aaagtggaaa 960 actccatttg agaagaaact aaatgggctt tatcctttcc gtgtaaactc ggctcagcgc 1020 acacctgtac agatgatgta cttgcgtgaa aagctaaaca ttggatacat agaagaccta 1080 aaggctcaga ttctagaact cccatatgct ggagatgtta gcatgttctt gttgcttcca 1140 gatgaaattg ccgatgtgtc cactggcttg gagctgctgg aaagtgaaat aacctatgac 1200 aaactcaaca agtggaccag caaagacaaa atggctgaag atgaagttga ggtatacata 1260 ccccagttca aattagaaga gcattatgaa ctcagatcca ttctgagaag catgggcatg 1320 gaggacgcct tcaacaaggg acgggccaat ttctcaggga tgtcggagag gaatgacctg 1380 tttctttctg aagtgttcca ccaagccatg gtggatgtga atgaggaggg cactgaagca 1440 gccgctggca caggaggtgt tatgacaggg agaactggac atggaggccc acagtttgtg 1500 gcagatcatc cttttctttt tcttattatg cataagataa ccaactgcat tttatttttc 1560 ggcagatttt cctcacccta aaactaagcg tgctgcttct gcaaaagatt tttgtagatg 1620 agctgtgtgc ctcagaattg ctatttcaaa ttgccaaaaa tttagagatg ttttctacat 1680 atttctgctc ttctgaacaa cttctgctac ccactaaata aaaacacaga aataattaga 1740 caattgtcta ttataacatg acaaccctat taatcatttg gtcttctaaa atgggatcat 1800 gcccatttag attttcctta ctatcagttt atttttataa cattaacttt tactttgtta 1860 tttattattt tatataatgg tgagttttta aattattgct cactgcctat ttaatgtagc 1920 taataaagtt atagaagcag atgatctgtt aatttcctat ctaataaatg cctttaattg 1980 ttctcataat gaagaataag taggtatccc tccatgccct tctgtaataa atatctggaa 2040 aaaacattaa acaataggca aatatatgtt atgtgcattt ctagaaatac ataacacata 2100 tatatgtctg tatcttatat tcaattgcaa gtatataata aataaacctg cttccaaaca 2160 acaataaaaa aaaaaaaaaa 2180 <210> 260 <211> 2259 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2259) <223> SERPINE2 mRNA <400> 260 cgataaagcc cccgccgccg cggcagccag cttgcgctgt ggggctgccc gggctgcgcg 60 gcgtctgcag gcgccaccgc tgcctctttc cggctgtgac cctcctcgcc gccgccgctt 120 ggctgcgtcc tccgactccc cgcgccgccg agaccaggct cccgctccgg ttgcggccgc 180 accgccctcc gcggccgccc cctggggatc cagcgagcgc ggtcgtcctt ggtggaagga 240 accatgaact ggcatctccc cctcttcctc ttggcctctg tgacgctgcc ttccatctgc 300 tcccacttca atcctctgtc tctcgaggaa ctaggctcca acacggggat ccaggttttc 360 aatcagattg tgaagtcgag gcctcatgac aacatcgtga tctctcccca tgggattgcg 420 tcggtcctgg ggatgcttca gctgggggcg gacggcagga ccaagaagca gctcgccatg 480 gtgatgagat acggcgtaaa tggagttggt aaaatattaa agaagatcaa caaggccatc 540 gtctccaaga agaataaaga cattgtgaca gtggctaacg ccgtgtttgt taagaatgcc 600 tctgaaattg aagtgccttt tgttacaagg aacaaagatg tgttccagtg tgaggtccgg 660 aatgtgaact ttgaggatcc agcctctgcc tgtgattcca tcaatgcatg ggttaaaaat 720 gaaaccaggg atatgattga caatctgctg tccccagatc ttattgatgg tgtgctcacc 780 agactggtcc tcgtcaacgc agtgtatttc aagggtctgt ggaaatcacg gttccaaccc 840 gagaacacaa agaaacgcac tttcgtggca gccgacggga aatcctatca agtgccaatg 900 ctggcccagc tctccgtgtt ccggtgtggg tcgacaagtg cccccaatga tttatggtac 960 aacttcattg aactgcccta ccacggggaa agcatcagca tgctgattgc actgccgact 1020 gagagctcca ctccgctgtc tgccatcatc ccacacatca gcaccaagac catagacagc 1080 tggatgagca tcatggtgcc caagagggtg caggtgatcc tgcccaagtt cacagctgta 1140 gcacaaacag atttgaagga gccgctgaaa gttcttggca ttactgacat gtttgattca 1200 tcaaaggcaa attttgcaaa aataacaaca gggtcagaaa acctccatgt ttctcatatc 1260 ttgcaaaaag caaaaattga agtcagtgaa gatggaacca aagcttcagc agcaacaact 1320 gcaattctca ttgcaagatc atcgcctccc tggtttatag tagacagacc ttttctgttt 1380 ttcatccgac ataatcctac aggtgctgtg ttattcatgg ggcagataaa caaaccctga 1440 agagtataca aaagaaacca tgcaaagcaa cgactacttt gctacgaaga aagactcctt 1500 tcctgcatct ttcatagttc tgttaaatat ttttgtacat cgcttctttt tcaaaactag 1560 ttcttaggaa cagactcgat gcaagtgttt ctgttctggg aggtattgga gggaaaaaac 1620 aagcaggatg gctggaacac tgtactgagg aatgaataga aaggcttcca gatgtctaaa 1680 agattcttta aactactgaa ctgttaccta ggttaacaac cctgttgagt atttgctgtt 1740 tgtccagttc aggaattttt gttttgtttt gtctatatgt gcggcttttc agaagaaatt 1800 taatcagtgt gacagaaaaa aaaatgtttt atggtagctt ttacttttta tgaaaaaaaa 1860 attatttgcc ttttaaattc ttttccccca tccccctcca aagtcttgat agcaagcgtt 1920 attttggggg tagaaacggt gaaatctcta gcctctttgt gtttttgttg ttgttgttgt 1980 tgttgtttta tataatgcat gtattcacta aaataaaatt taaaaaactc ctgtcttgct 2040 agacaaggtt gctgttgtgc agtgtgcctg tcactactgg tctgtactcc ttggatttgc 2100 atttttgtat tttgtacaaa gtaaaaataa actgttatga gtagtaaaaa taaagctatt 2160 tctctgctat ttgaaaatac aatagaagaa actgagcctt ttagacattc gtcagcctct 2220 tctaataaac ctttgtacta tgtaaacatc aggaaattc 2259 <210> 261 <211> 3297 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3297) <223> SLC20A1 mRNA <400> 261 ggagtgatgg ctgccggcgc tctctgcgtg gttcttcttc tcggccgctg aaacccccgc 60 ggctgcttcc tgggaaggtc gtgagtcccg ctgagctgtc cccggtgccg ccgacccggg 120 ccgtgtgccc gtggctccag ccgctgtcgc ctcgatctcc tcgtctcccg ctccgccctc 180 ccttttccct ggatgaactt gcgtcctttc tcttctccgc catggaattc tgctccgtgc 240 ttttagccct cctgagccaa agaaacccca gacaacagat gcccatacgc agcgtatagc 300 agtaactccc cagctcggtt tctgtgccgt agtttacagt atttaatttt atataatata 360 tattatttat tatagcattt ttgatacctc atattctgtt tacacatctt gaaaggcgct 420 cagtagttct cttactaaac aaccactact ccagagaatg gcaacgctga ttaccagtac 480 tacagctgct accgccgctt ctggtccttt ggtggactac ctatggatgc tcatcctggg 540 cttcattatt gcatttgtct tggcattctc cgtgggagcc aatgatgtag caaattcttt 600 tggtacagct gtgggctcag gtgtagtgac cctgaagcaa gcctgcatcc tagctagcat 660 ctttgaaaca gtgggctctg tcttactggg ggccaaagtg agcgaaacca tccggaaggg 720 cttgattgac gtggagatgt acaactcgac tcaagggctg ctgatggccg gctcagtcag 780 tgctatgttt ggttctgctg tgtggcaact cgtggcttcg tttttgaagc tccctatttc 840 tggaacccat tgtattgttg gtgcaactat tggtttctcc ctcgtggcaa aggggcagga 900 gggtgtcaag tggtctgaac tgataaaaat tgtgatgtct tggttcgtgt ccccactgct 960 ttctggaatt atgtctggaa ttttattctt cctggttcgt gcattcatcc tccataaggc 1020 agatccagtt cctaatggtt tgcgagcttt gccagttttc tatgcctgca cagttggaat 1080 aaacctcttt tccatcatgt atactggagc accgttgctg ggctttgaca aacttcctct 1140 gtggggtacc atcctcatct cggtgggatg tgcagttttc tgtgccctta tcgtctggtt 1200 ctttgtatgt cccaggatga agagaaaaat tgaacgagaa ataaagtgta gtccttctga 1260 aagcccctta atggaaaaaa agaatagctt gaaagaagac catgaagaaa caaagttgtc 1320 tgttggtgat attgaaaaca agcatcctgt ttctgaggta gggcctgcca ctgtgcccct 1380 ccaggctgtg gtggaggaga gaacagtctc attcaaactt ggagatttgg aggaagctcc 1440 agagagagag aggcttccca gcgtggactt gaaagaggaa accagcatag atagcaccgt 1500 gaatggtgca gtgcagttgc ctaatgggaa ccttgtccag ttcagtcaag ccgtcagcaa 1560 ccaaataaac tccagtggcc actaccagta tcacaccgtg cataaggatt ccggcctgta 1620 caaagagcta ctccataaat tacatcttgc caaggtggga gattgcatgg gagactccgg 1680 tgacaaaccc ttaaggcgca ataatagcta tacttcctat accatggcaa tatgtggcat 1740 gcctctggat tcattccgtg ccaaagaagg tgaacagaag ggcgaagaaa tggagaagct 1800 gacatggcct aatgcagact ccaagaagcg aattcgaatg gacagttaca ccagttactg 1860 caatgctgtg tctgaccttc actcagcatc tgagatagac atgagtgtca aggcagagat 1920 gggtctaggt gacagaaaag gaagtaatgg ctctctagaa gaatggtatg accaggataa 1980 gcctgaagtc tctctcctct tccagttcct gcagatcctt acagcctgct ttgggtcatt 2040 cgcccatggt ggcaatgacg taagcaatgc cattgggcct ctggttgctt tatatttggt 2100 ttatgacaca ggagatgttt cttcaaaagt ggcaacacca atatggcttc tactctatgg 2160 tggtgttggt atctgtgttg gtctgtgggt ttggggaaga agagttatcc agaccatggg 2220 gaaggatctg acaccgatca caccctctag tggcttcagt attgaactgg catctgccct 2280 cactgtggtg attgcatcaa atattggcct tcccatcagt acaacacatt gtaaagtggg 2340 ctctgttgtg tctgttggct ggctccggtc caagaaggct gttgactggc gtctctttcg 2400 taacattttt atggcctggt ttgtcacagt ccccatttct ggagttatca gtgctgccat 2460 catggcaatc ttcagatatg tcatcctcag aatgtgaagc tgtttgagat taaaatttgt 2520 gtcaatgttt gggaccatct taggtattcc tgctcccctg aagaatgatt acagtgttaa 2580 cagaagactg acaagagtct ttttatttgg gagccagagg agggaagtgt tacttgtgct 2640 ataactgctt ttgtgctaaa tatgaattgt ctcaaaatta gctgtgtaaa atagcccggg 2700 ttccactggc tcctgctgag gtcccctttc cttctgggct gtgaattcct gtacatattt 2760 ctctactttt tgtatcaggc ttcaattcca ttatgtttta atgttgtctc tgaagatgac 2820 ttgtgatttt tttttctttt ttttaaacca tgaagagccg tttgacagag catgctctgc 2880 gttgttggtt tcaccagctt ctgccctcac atgcacaggg atttaacaac aaaaatataa 2940 ctacaacttc ccttgtagtc tcttatataa gtagagtcct tggtactctg ccctcctgtc 3000 agtagtggca ggatctattg gcatattcgg gagcttctta gagggatgag gttctttgaa 3060 cacagtgaaa atttaaatta gtaacttttt tgcaagcagt ttattgactg ttattgctaa 3120 gaagaagtaa gaaagaaaaa gcctgttggc aatcttggtt atttctttaa gatttctggc 3180 agtgtgggat ggatgaatga agtggaatgt gaactttggg caagttaagt gggacagcct 3240 tccatgttca tttgtctacc tcttaactga ataaaaaagc ctacagtttt tagaaaa 3297 <210> 262 <211> 8057 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(8057) <223> SLIT2 mRNA <400> 262 acttggtgtt atttatttgg gaagcgcccg gacggcggag cttggcggcg gcggtggtgg 60 tggctgccgc agactgtggt taaaaaaaag aaggcggcgg cggcggcggc ggcggaggcg 120 gaggcagctg cgaggcatgg gagcgccgaa gcgcccaggc gcaggccgaa gctgccgcgc 180 tttctgggca cggcgggagt gctgagcaga aaggggagcg ccgggggccc gcagccggct 240 ccggaggcgc gggccgggtt tttgtttggc tacgctgagc gccagtcagc cccagcgaac 300 aactccagtt acgacaacaa cccaccttcc ttccagacaa gcgagacttg ggctgctgcg 360 tccgtcctat tgtttagaca cttgccaggg gctccggagt cggcagagcc accgagtccc 420 cgctctgagt cgtcgccctc cctctccccg acctcgctcc ctggagcggg aggccaggaa 480 agcagcggga gaggggaagg ggctagaagg agaaggacta cccgggactg cggccgccgc 540 gtcaggtgca gcgccaggag ccgggcggcg tcgccacgcc ggcaggggta ccgccactgt 600 ggccttgggg gacggaattc aaagcctggg aaaagttgct gcactttgag aaggacgaac 660 cactagtggg agaccgccgg gggccggccg tggctctgcg ccctccggaa cccggctctt 720 gtttcttcta cctttgccat caggtgtctg ccgcggagct gcggcttatc tgggagacga 780 gcggggttga cacgcgcgca cacactactg ccattcagct gccgcctggc tctgcctgga 840 gtagtggatc ccacccgccc acctgccacc gagccattct ccagtacgcc ccagcaggac 900 gctgacacct ccaaccttgg cctttgcctt tccactcctt ccggtctgcc tggtttttaa 960 gtccgccccc agtcagtccc cactcagtct tcgcagcagc tctcatcctc cacttggcct 1020 cttggagttc ctcgccggag tgctgactag tggatatttc tgcccggctg cggcggcccg 1080 actgcccttt tgtcttttct gcgtgacctc ggggcaggtc ctggtgcaga gcgtcgccaa 1140 ggacgccgag cgggaggcgg gattgcccag acatccttca gcgaagtgca tgtgtgtttg 1200 taaaccatcg ttggctgtcg ggagaccgcg aggaccggtc caggctgcgg cggagtcgag 1260 ggcgagggag aggccgcgtg agtgagcaga gtccagagcc gtgcgccccc agaactgcgc 1320 gtccgccccg tgcacccccg cgcgccatgc ccagttgccc cgcgcgctct gctacgggcc 1380 cgctgggctt ccgcgccttc tagcttccgg agcccacttt gatcggggcc ataataccta 1440 ttgagatccc ctcttctgtc ttgtaccttc gccactggca tcggatttgc agaagcgtgc 1500 gtgggatcag aggaccgccc tccccacaac aaccggcccc tgcatcttag cagccgttgg 1560 aagccccagc tcttttaccg ccaagttcat ccttgggaga cagaagacgc gtgatctcct 1620 ctccgctgct cttggggtct ccttgcagcc ctggccaggc ggattcatcc tcaggaccta 1680 aagttgccca aggagctcct gctctgccag aggagggtgg agagggcggt gggaggcgtg 1740 tgcctgagtg ggctctactg ccttgttcca tattatttgg tgcacatttt ccctggcact 1800 ctgggttgct agccccgccg ggcactgggc ctcagacact gcgcggttcc ctcggagcag 1860 caagctaaag aaagccccca gtgccggcga ggaaggaggc ggcggggaaa gatgcgcggc 1920 gttggctggc agatgctgtc cctgtcgctg gggttagtgc tggcgatcct gaacaaggtg 1980 gcaccgcagg cgtgcccggc gcagtgctct tgctcgggca gcacagtgga ctgtcacggg 2040 ctggcgctgc gcagcgtgcc caggaatatc ccccgcaaca ccgagagact ggatttaaat 2100 ggaaataaca tcacaagaat tacgaagaca gattttgctg gtcttagaca tctaagagtt 2160 cttcagctta tggagaataa gattagcacc attgaaagag gagcattcca ggatcttaaa 2220 gaactagaga gactgcgttt aaacagaaat caccttcagc tgtttcctga gttgctgttt 2280 cttgggactg cgaagctata caggcttgat ctcagtgaaa accaaattca ggcaatccca 2340 aggaaagctt tccgtggggc agttgacata aaaaatttgc aactggatta caaccagatc 2400 agctgtattg aagatggggc attcagggct ctccgggacc tggaagtgct cactctcaac 2460 aataacaaca ttactagact ttctgtggca agtttcaacc atatgcctaa acttaggact 2520 tttcgactgc attcaaacaa cctgtattgt gactgccacc tggcctggct ctccgactgg 2580 cttcgccaaa ggcctcgggt tggtctgtac actcagtgta tgggcccctc ccacctgaga 2640 ggccataatg tagccgaggt tcaaaaacga gaatttgtct gcagtggtca ccagtcattt 2700 atggctcctt cttgtagtgt tttgcactgc cctgccgcct gtacctgtag caacaatatc 2760 gtagactgtc gtgggaaagg tctcactgag atccccacaa atcttccaga gaccatcaca 2820 gaaatacgtt tggaacagaa cacaatcaaa gtcatccctc ctggagcttt ctcaccatat 2880 aaaaagctta gacgaattga cctgagcaat aatcagatct ctgaacttgc accagatgct 2940 ttccaaggac tacgctctct gaattcactt gtcctctatg gaaataaaat cacagaactc 3000 cccaaaagtt tatttgaagg actgttttcc ttacagctcc tattattgaa tgccaacaag 3060 ataaactgcc ttcgggtaga tgcttttcag gatctccaca acttgaacct tctctcccta 3120 tatgacaaca agcttcagac catcgccaag gggacctttt cacctcttcg ggccattcaa 3180 actatgcatt tggcccagaa cccctttatt tgtgactgcc atctcaagtg gctagcggat 3240 tatctccata ccaacccgat tgagaccagt ggtgcccgtt gcaccagccc ccgccgcctg 3300 gcaaacaaaa gaattggaca gatcaaaagc aagaaattcc gttgttcagc taaagaacag 3360 tatttcattc caggtacaga agattatcga tcaaaattaa gtggagactg ctttgcggat 3420 ctggcttgcc ctgaaaagtg tcgctgtgaa ggaaccacag tagattgctc taatcaaaag 3480 ctcaacaaaa tcccggagca cattccccag tacactgcag agttgcgtct caataataat 3540 gaatttaccg tgttggaagc cacaggaatc tttaagaaac ttcctcaatt acgtaaaata 3600 aactttagca acaataagat cacagatatt gaggagggag catttgaagg agcatctggt 3660 gtaaatgaaa tacttcttac gagtaatcgt ttggaaaatg tgcagcataa gatgttcaag 3720 ggattggaaa gcctcaaaac tttgatgttg agaagcaatc gaataacctg tgtggggaat 3780 gacagtttca taggactcag ttctgtgcgt ttgctttctt tgtatgataa tcaaattact 3840 acagttgcac caggggcatt tgatactctc cattctttat ctactctaaa cctcttggcc 3900 aatcctttta actgtaactg ctacctggct tggttgggag agtggctgag aaagaagaga 3960 attgtcacgg gaaatcctag atgtcaaaaa ccatacttcc tgaaagaaat acccatccag 4020 gatgtggcca ttcaggactt cacttgtgat gacggaaatg atgacaatag ttgctcccca 4080 ctttctcgct gtcctactga atgtacttgc ttggatacag tcgtccgatg tagcaacaag 4140 ggtttgaagg tcttgccgaa aggtattcca agagatgtca cagagttgta tctggatgga 4200 aaccaattta cactggttcc caaggaactc tccaactaca aacatttaac acttatagac 4260 ttaagtaaca acagaataag cacgctttct aatcagagct tcagcaacat gacccagctc 4320 ctcaccttaa ttcttagtta caaccgtctg agatgtattc ctcctcgcac ctttgatgga 4380 ttaaagtctc ttcgattact ttctctacat ggaaatgaca tttctgttgt gcctgaaggt 4440 gctttcaatg atctttctgc attatcacat ctagcaattg gagccaaccc tctttactgt 4500 gattgtaaca tgcagtggtt atccgactgg gtgaagtcgg aatataagga gcctggaatt 4560 gctcgttgtg ctggtcctgg agaaatggca gataaacttt tactcacaac tccctccaaa 4620 aaatttacct gtcaaggtcc tgtggatgtc aatattctag ctaagtgtaa cccctgccta 4680 tcaaatccgt gtaaaaatga tggcacatgt aatagtgatc cagttgactt ttaccgatgc 4740 acctgtccat atggtttcaa ggggcaggac tgtgatgtcc caattcatgc ctgcatcagt 4800 aacccatgta aacatggagg aacttgccac ttaaaggaag gagaagaaga tggattctgg 4860 tgtatttgtg ctgatggatt tgaaggagaa aattgtgaag tcaacgttga tgattgtgaa 4920 gataatgact gtgaaaataa ttctacatgt gtcgatggca ttaataacta cacatgcctt 4980 tgcccacctg agtatacagg tgagttgtgt gaggagaagc tggacttctg tgcccaggac 5040 ctgaacccct gccagcacga ttcaaagtgc atcctaactc caaagggatt caaatgtgac 5100 tgcacaccag ggtacgtagg tgaacactgc gacatcgatt ttgacgactg ccaagacaac 5160 aagtgtaaaa acggagccca ctgcacagat gcagtgaacg gctatacgtg catatgcccc 5220 gaaggttaca gtggcttgtt ctgtgagttt tctccaccca tggtcctccc tcgtaccagc 5280 ccctgtgata attttgattg tcagaatgga gctcagtgta tcgtcagaat aaatgagcca 5340 atatgtcagt gtttgcctgg ctatcaggga gaaaagtgtg aaaaattggt tagtgtgaat 5400 tttataaaca aagagtctta tcttcagatt ccttcagcca aggttcggcc tcagacgaac 5460 ataacacttc agattgccac agatgaagac agcggaatcc tcctgtataa gggtgacaaa 5520 gaccatatcg cggtagaact ctatcggggg cgtgttcgtg ccagctatga caccggctct 5580 catccagctt ctgccattta cagtgtggag acaatcaatg atggaaactt ccacattgtg 5640 gaactacttg ccttggatca gagtctctct ttgtccgtgg atggtgggaa ccccaaaatc 5700 atcactaact tgtcaaagca gtccactctg aattttgact ctccactcta tgtaggaggc 5760 atgccaggga agagtaacgt ggcatctctg cgccaggccc ctgggcagaa cggaaccagc 5820 ttccacggct gcatccggaa cctttacatc aacagtgagc tgcaggactt ccagaaggtg 5880 ccgatgcaaa caggcatttt gcctggctgt gagccatgcc acaagaaggt gtgtgcccat 5940 ggcacatgcc agcccagcag ccaggcaggc ttcacctgcg agtgccagga aggatggatg 6000 gggcccctct gtgaccaacg gaccaatgac ccttgccttg gaaataaatg cgtacatggc 6060 acctgcttgc ccatcaatgc gttctcctac agctgtaagt gcttggaggg ccatggaggt 6120 gtcctctgtg atgaagagga ggatctgttt aacccatgcc aggcgatcaa gtgcaagcat 6180 gggaagtgca ggctttcagg tctggggcag ccctactgtg aatgcagcag tggatacacg 6240 ggggacagct gtgatcgaga aatctcttgt cgaggggaaa ggataagaga ttattaccaa 6300 aagcagcagg gctatgctgc ttgccaaaca accaagaagg tgtcccgatt agagtgcaga 6360 ggtgggtgtg caggagggca gtgctgtgga ccgctgagga gcaagcggcg gaaatactct 6420 ttcgaatgca ctgacggctc ctcctttgtg gacgaggttg agaaagtggt gaagtgcggc 6480 tgtacgaggt gtgtgtccta aacacactcc cggcagctct gtctttggaa aaggttgtat 6540 acttcttgac cgtgtgggac taatgaatgc ttcatagtgg aaatatttga aatatattgt 6600 aaaatacaga acagacttat ttttattatg agaataaaga ctttttttct gcatttggaa 6660 aaaaaaaaaa agaaatgctt gaactaaagc ttcccctatg ctggagaagt atgaagaaag 6720 atatacctgg agacattaga acagcgatgg gaaccattgc aactcgggtc catctttgta 6780 acatgctgaa gacaagcaga agcacatgca cgagggacag aggagctact gtgcactgct 6840 gtgaaattgc ccagagcata aaacctgtgt accctccttc acatcaacca agttcactag 6900 gacataccaa gcacatgcgt gtgaatgagg atgcaaggca agagaatgga actccagaat 6960 tcacagatag aacaaatgga tgagaaatat ttcatgcaaa atataaagtg tcctgaggat 7020 ctgggttcca tttacgagag gaaatgaaag tgctaaaata aattttatct tccttttaaa 7080 tgtcagcatg tcagcagaag cagcacacaa aagtctttac cattttccag tattaatttt 7140 tttgtaatat aaatgataaa ggagatgata aagaaccaat agattattga taaataaatt 7200 agtaataata tgattttttg tttctatgag ttctaaacag ccctatacag tattcagttt 7260 ccatgagaaa tatttattgt atcaaagtac attgtactta acattttagg ccatcctttt 7320 actgttcctt gatgctttaa tatatattaa tttataatta tcctgatatt tttgtacatt 7380 tttcaaactt aaaaatcagg attttttttt tttttttttt ggcaatagta ctaacatagg 7440 gttttatctt gggatacata tgtattggtc tgtttgttga ccttgacatc tgatcactga 7500 tgtcaatgac ctactggcct cattcaggac acctgcagag agtatgcaaa gtccgagaga 7560 ggaaaacaga aatctgtatg tgagatggtc attgtacaga aagaagtggc ccctctgcaa 7620 catgtcctca cagaaacgaa atggtgtgta gcaatcaaca ctagaaagta gaccttttgc 7680 aaattaatat gtccttgacc ttttttgccc ttttgtgggg gtgaggtggg gataaaaaga 7740 ctgtcatatc aagaactgtg acttttcttt ccctcaaaca ataaaactcc tttattatct 7800 taatgctccc atgttaacat gtttgctgct aaattacaat gtagaattga taatggttta 7860 tagtgaactg tgctcttccc tcattaaaat cccagggtgc cctgtaaaga tgcagatgtt 7920 tcttcctgaa aacttctttt tttacaaaga aaattagatg tacatgtata attcagtgtg 7980 ctttgtcttt ctccagatta atatcggtta cactgctgat gtttgtaaat taaacagata 8040 tttacttcat taaaaaa 8057 <210> 263 <211> 6240 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6240) <223> SMURF2 mRNA <400> 263 agacaagagg gcgggtggag gaggaagcgg ccgagcccag agttctgctc cggcgccccc 60 gagcaccgcc cgcttcagcc gaccagcccc gtcggctact gggcctcgcc gagacgagag 120 gagggaaagg cctcggcggc cgcgaggagg cggcgggggc gcgggcggag gcggcgcggg 180 cggccgcggc tgccgctttg ttgtgcggcc cgggccgagg aaggagaagt gggaggaggg 240 gggagctcgg cgtcccgctc cctccgcggc tcatggcgac gactctcggc acatccggga 300 ccctccggcc gtggcggccg aggcgccggc tgctcgggcc ccagccccgg ccgctgtggt 360 gactccgccg cgcctcgccg tcgcccccgt gccgcccgcc gcccccgccg cccccgccgc 420 cggggacatg tctaaccccg gaggccggag gaacgggccc gtcaagctgc gcctgacagt 480 actctgtgca aaaaacctgg tgaaaaagga ttttttccga cttcctgatc catttgctaa 540 ggtggtggtt gatggatctg ggcaatgcca ttctacagat actgtgaaga atacgcttga 600 tccaaagtgg aatcagcatt atgacctgta tattggaaag tctgattcag ttacgatcag 660 tgtatggaat cacaagaaga tccataagaa acaaggtgct ggatttctcg gttgtgttcg 720 tcttctttcc aatgccatca accgcctcaa agacactggt tatcagaggt tggatttatg 780 caaactcggg ccaaatgaca atgatacagt tagaggacag atagtagtaa gtcttcagtc 840 cagagaccga ataggcacag gaggacaagt tgtggactgc agtcgtttat ttgataacga 900 tttaccagac ggctgggaag aaaggagaac cgcctctgga agaatccagt atctaaacca 960 tataacaaga actacgcaat gggagcgccc aacacgaccg gcatccgaat attctagccc 1020 tggcagacct cttagctgct ttgttgatga gaacactcca attagtggaa caaatggtgc 1080 aacatgtgga cagtcttcag atcccaggct ggcagagagg agagtcaggt cacaacgaca 1140 tagaaattac atgagcagaa cacatttaca tactcctcca gacctaccag aaggctatga 1200 acagaggaca acgcaacaag gccaggtgta tttcttacat acacagactg gtgtgagcac 1260 atggcatgat ccaagagtgc ccagggatct tagcaacatc aattgtgaag agcttggtcc 1320 attgcctcct ggatgggaga tccgtaatac ggcaacaggc agagtttatt tcgttgacca 1380 taacaacaga acaacacaat ttacagatcc tcggctgtct gctaacttgc atttagtttt 1440 aaatcggcag aaccaattga aagaccaaca gcaacagcaa gtggtatcgt tatgtcctga 1500 tgacacagaa tgcctgacag tcccaaggta caagcgagac ctggttcaga aactaaaaat 1560 tttgcggcaa gaactttccc aacaacagcc tcaggcaggt cattgccgca ttgaggtttc 1620 cagggaagag atttttgagg aatcatatcg acaggtcatg aaaatgagac caaaagatct 1680 ctggaagcga ttaatgataa aatttcgtgg agaagaaggc cttgactatg gaggcgttgc 1740 cagggaatgg ttgtatctct tgtcacatga aatgttgaat ccatactatg gcctcttcca 1800 gtattcaaga gatgatattt atacattgca gatcaatcct gattctgcag ttaatccgga 1860 acatttatcc tatttccact ttgttggacg aataatggga atggctgtgt ttcatggaca 1920 ttatattgat ggtggtttca cattgccttt ttataagcaa ttgcttggga agtcaattac 1980 cttggatgac atggagttag tagatccgga tcttcacaac agtttagtgt ggatacttga 2040 gaatgatatt acaggtgttt tggaccatac cttctgtgtt gaacataatg catatggtga 2100 aattattcag catgaactta aaccaaatgg caaaagtatc cctgttaatg aagaaaataa 2160 aaaagaatat gtcaggctct atgtgaactg gagattttta cgaggcattg aggctcaatt 2220 cttggctctg cagaaaggat ttaatgaagt aattccacaa catctgctga agacatttga 2280 tgagaaggag ttagagctca ttatttgtgg acttggaaag atagatgtta atgactggaa 2340 ggtaaacacc cggttaaaac actgtacacc agacagcaac attgtcaaat ggttctggaa 2400 agctgtggag ttttttgatg aagagcgacg agcaagattg cttcagtttg tgacaggatc 2460 ctctcgagtg cctctgcagg gcttcaaagc attgcaaggt gctgcaggcc cgagactctt 2520 taccatacac cagattgatg cctgcactaa caacctgccg aaagcccaca cttgcttcaa 2580 tcgaatagac attccaccct atgaaagcta tgaaaagcta tatgaaaagc tgctaacagc 2640 cattgaagaa acatgtggat ttgctgtgga atgacaagct tcaaggattt acccaggact 2700 ctatttatac aaccctgact gacagcctcc tttcagcaga gtttcaaaga atatgctgaa 2760 atacaggaaa acactccccc cccccccctt tttttttttt tttttacatt ttaggacact 2820 gtgaggggaa aggacaattt tgaaattcct tttcaaggaa aaaaaaggtc tttatgcttt 2880 gccatgaggc cacattcagc tgctatttaa acttaatatc ttgaacctaa agaatgctga 2940 cttttcctac atttccagag ttaggcagta ttctacactt aaagactact actattttta 3000 taaaaggtaa tctattcaaa tttcttcaca gatttcaagt ctctcaaaca tcaagacaac 3060 ttcagcagtc ggtacaagtc acatttcatt ttgattgaat acatgatctt gaacagctcc 3120 tgtacttgct ctttgtaaaa aaaaataaaa ttattttgaa ttattctacc tttgtaaaca 3180 attggctaaa agaatcatct ttaagaaatt aagccattta catgtttgtg tttttctata 3240 gcagagcatt atattttgca ttatatgttt caacctagtc taagtgggtc ttttttacat 3300 ttttcaagaa cggatttcct ggaatacagc gatataattt tggttgtcaa attcctaatg 3360 caaccattta gtctaaactt agtcatttat ttgtgacaat aagatgtgtt caggggctcc 3420 ctgtttttaa gagactcttt taaaaaaaaa aaaacctaat gtttttatct tgagtcaata 3480 tgattaggta ttttggattt acttttaatc ttaaaatact gcatttttat agcttctcag 3540 agcatgtgga tgggatggga ttttcgttat tttgctgggt cagcttatct ttaatatatg 3600 gactattcct ataaaccaaa gtctctgaca agtgcaccta atttatattg tattttaact 3660 acagtgtaag tttccattaa caaaaccatc ctaaagcgtt aactgctcat aattttaatc 3720 agctacagtt atgaaaaagg aagaattttg ctctaaagat tattaataag cttagaaaat 3780 cctgctttta cctaacagaa tgaagtgggg ttgaggggcg gtagtatgaa cagtgattct 3840 aactctatgg cgtaaattac tttgaagagt tcattttgga agtaagggaa tcccgcttcc 3900 cttggtgttg aagatctgca tctgattttg aaacgtccag atttagcttt caaggtgcgt 3960 gcatgttgaa tgatccagaa gcaacgaaaa ctctggggtg agggattgaa aaaatctgaa 4020 atcacagttg gatttttaaa ttcaaccatc aaaaatatgt actatcagtt tttttttaca 4080 ttgatgtgaa ataagcaaat tttcatgata attaagctgc aaaatttaaa gttatcaagt 4140 aaataggtcc tctgtgttct gtttcatgtg atggagtggg tttcagtctg tgttcttgga 4200 gccaaagggt tcctcagggg tgcctcagga gtaatggttt aagagaagag gggcaatgag 4260 agggagcgag ggggaaggcc tagttggtat ttgagcaggg gccttaggct ccatatcccc 4320 acccccttta cccagaacag cccatttttc ttatgtatat tggaatttca agtaagcttt 4380 catggggtgc agtggggcgg ggaggaatgg atgggataaa aaaagtggag attttgctgc 4440 tttaaaaaag ttgagaacta cttgtgtagt ttttaagtat tttaatgtat ttcatttggc 4500 caaattcaac tgccacaagc aagctagtca tagttgtaac tgtgcagtgg taatatgctt 4560 atgcctacct ttttcctctc aaacaatttg ttttttttac attgcattct gagtactgaa 4620 gagcatcttg aaatgtatgg aagtggtttc tatgctattt gataatcagt aatgttcagc 4680 tgtcatgata gtactttact ggttgcagac ccatctctct tttatattaa agcactagtg 4740 cagtttataa ttgtgcctac ttttaaaatc tttcagtaaa aaagtacata atgaatacag 4800 aaatcataac tgacagggat acagtaataa tgaaatgcta ctatcactta ttttaatata 4860 caatataaag caggcaaata ccattgcttt ttgagtgcct ttttaacttt atactaatga 4920 cttaatagag ctttaaaaga aagaaattgg ctgggcatgg tggctcacac ctgtaatccc 4980 agcactttgg gaggccgagg tgggcggatc acctgaggtc aggagttcga gaccagcctg 5040 gccaacgtgg tgaaaccctg tctctactaa aaatacaaaa tttagccggg catggtggcg 5100 cactcctgta atccaactac ttgggaggct gaggcaggag aattgcttga atctgggagg 5160 cagagattgc agtgagccga gatcgcacca ctgcactcca gcctgggcga caagagtgag 5220 actccgtccc cgcccaaaaa aaaaaaaaaa agaaattact ctccataaca gtctatgtta 5280 tcaccaacat atataaaaac atgatttaga tttccatttc aaagttacat tacccgatta 5340 cttccaaata ggtgctaagc aaaaaccccc aatgtattat tgaaccatgg acttgcacct 5400 catgtttaat gtgaatattt atttccatgt ccctcttaac tggttttttc ttgtcttccc 5460 tctagctgta ttgttatttc agatatgtga tatctgtttt catactcttg cctttccatc 5520 atgaatgctt agttatgaac agagattcct ttgtagagct cataggcagt acagagaggt 5580 aagtcttgcc tcagagggcc ttgtatcttg gtgtagtttt taaatagtgc atagtgtata 5640 gtgtatagtg tacattttgt tttgcacata gtttgttgcc ccgaatgggt tttttaccaa 5700 gccttttttt ctttcatgta tttacagtcc ggagcacaag attctcttct ttcaaataca 5760 atgtaattcg ctttacttta caacactaaa tctgggcttt gaatttccag tgcattggac 5820 tgattggatt gttgggagtt agaggctgtt ccaaccatcc ttagtttggg agagtggctc 5880 cttctgcttg ttttctaagc gtacagtcaa cgggtgccat ttgtggtatt taacatgtta 5940 ggatgattgt tccaaatgct gagttgtttt atttctagat gtaattagtt cactttatgt 6000 aatattcttc tctcagactg actttaaaaa caaagtttta tcattttcat tgtatttgta 6060 tttattacag agtgttttag ctttgatatt ctttgtattt tcattcattt gttacatgag 6120 ctttatcagt aacatctgta taaatggttt ttaaaaatta actatgtatg tgcccatgcc 6180 gaagtcgagc aataaaatca atgctgtttg cactgtcaca gcatcaacgt ttttaaagaa 6240 6240 <210> 264 <211> 4978 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4978) <223> STAT3 mRNA <400> 264 ggtttccgga gctgcggcgg cgcagactgg gagggggagc cgggggttcc gacgtcgcag 60 ccgagggaac aagccccaac cggatcctgg acaggcaccc cggcttggcg ctgtctctcc 120 ccctcggctc ggagaggccc ttcggcctga gggagcctcg ccgcccgtcc ccggcacacg 180 cgcagccccg gcctctcggc ctctgccgga gaaacagttg ggacccctga ttttagcagg 240 atggcccaat ggaatcagct acagcagctt gacacacggt acctggagca gctccatcag 300 ctctacagtg acagcttccc aatggagctg cggcagtttc tggccccttg gattgagagt 360 caagattggg catatgcggc cagcaaagaa tcacatgcca ctttggtgtt tcataatctc 420 ctgggagaga ttgaccagca gtatagccgc ttcctgcaag agtcgaatgt tctctatcag 480 cacaatctac gaagaatcaa gcagtttctt cagagcaggt atcttgagaa gccaatggag 540 attgcccgga ttgtggcccg gtgcctgtgg gaagaatcac gccttctaca gactgcagcc 600 actgcggccc agcaaggggg ccaggccaac caccccacag cagccgtggt gacggagaag 660 cagcagatgc tggagcagca ccttcaggat gtccggaaga gagtgcagga tctagaacag 720 aaaatgaaag tggtagagaa tctccaggat gactttgatt tcaactataa aaccctcaag 780 agtcaaggag acatgcaaga tctgaatgga aacaaccagt cagtgaccag gcagaagatg 840 cagcagctgg aacagatgct cactgcgctg gaccagatgc ggagaagcat cgtgagtgag 900 ctggcggggc ttttgtcagc gatggagtac gtgcagaaaa ctctcacgga cgaggagctg 960 gctgactgga agaggcggca acagattgcc tgcattggag gcccgcccaa catctgccta 1020 gatcggctag aaaactggat aacgtcatta gcagaatctc aacttcagac ccgtcaacaa 1080 attaagaaac tggaggagtt gcagcaaaaa gtttcctaca aaggggaccc cattgtacag 1140 caccggccga tgctggagga gagaatcgtg gagctgttta gaaacttaat gaaaagtgcc 1200 tttgtggtgg agcggcagcc ctgcatgccc atgcatcctg accggcccct cgtcatcaag 1260 accggcgtcc agttcactac taaagtcagg ttgctggtca aattccctga gttgaattat 1320 cagcttaaaa ttaaagtgtg cattgacaaa gactctgggg acgttgcagc tctcagagga 1380 tcccggaaat ttaacattct gggcacaaac acaaaagtga tgaacatgga agaatccaac 1440 aacggcagcc tctctgcaga attcaaacac ttgaccctga gggagcagag atgtgggaat 1500 gggggccgag ccaattgtga tgcttccctg attgtgactg aggagctgca cctgatcacc 1560 tttgagaccg aggtgtatca ccaaggcctc aagattgacc tagagaccca ctccttgcca 1620 gttgtggtga tctccaacat ctgtcagatg ccaaatgcct gggcgtccat cctgtggtac 1680 aacatgctga ccaacaatcc caagaatgta aactttttta ccaagccccc aattggaacc 1740 tgggatcaag tggccgaggt cctgagctgg cagttctcct ccaccaccaa gcgaggactg 1800 agcatcgagc agctgactac actggcagag aaactcttgg gacctggtgt gaattattca 1860 gggtgtcaga tcacatgggc taaattttgc aaagaaaaca tggctggcaa gggcttctcc 1920 ttctgggtct ggctggacaa tatcattgac cttgtgaaaa agtacatcct ggccctttgg 1980 aacgaagggt acatcatggg ctttatcagt aaggagcggg agcgggccat cttgagcact 2040 aagcctccag gcaccttcct gctaagattc agtgaaagca gcaaagaagg aggcgtcact 2100 ttcacttggg tggagaagga catcagcggt aagacccaga tccagtccgt ggaaccatac 2160 acaaagcagc agctgaacaa catgtcattt gctgaaatca tcatgggcta taagatcatg 2220 gatgctacca atatcctggt gtctccactg gtctatctct atcctgacat tcccaaggag 2280 gaggcattcg gaaagtattg tcggccagag agccaggagc atcctgaagc tgacccaggt 2340 agcgctgccc catacctgaa gaccaagttt atctgtgtga caccaacgac ctgcagcaat 2400 accattgacc tgccgatgtc cccccgcact ttagattcat tgatgcagtt tggaaataat 2460 ggtgaaggtg ctgaaccctc agcaggaggg cagtttgagt ccctcacctt tgacatggag 2520 ttgacctcgg agtgcgctac ctcccccatg tgaggagctg agaacggaag ctgcagaaag 2580 atacgactga ggcgcctacc tgcattctgc cacccctcac acagccaaac cccagatcat 2640 ctgaaactac taactttgtg gttccagatt ttttttaatc tcctacttct gctatctttg 2700 agcaatctgg gcacttttaa aaatagagaa atgagtgaat gtgggtgatc tgcttttatc 2760 taaatgcaaa taaggatgtg ttctctgaga cccatgatca ggggatgtgg cggggggtgg 2820 ctagagggag aaaaaggaaa tgtcttgtgt tgttttgttc ccctgccctc ctttctcagc 2880 agctttttgt tattgttgtt gttgttctta gacaagtgcc tcctggtgcc tgcggcatcc 2940 ttctgcctgt ttctgtaagc aaatgccaca ggccacctat agctacatac tcctggcatt 3000 gcacttttta accttgctga catccaaata gaagatagga ctatctaagc cctaggtttc 3060 tttttaaatt aagaaataat aacaattaaa gggcaaaaaa cactgtatca gcatagcctt 3120 tctgtattta agaaacttaa gcagccgggc atggtggctc acgcctgtaa tcccagcact 3180 ttgggaggcc gaggcggatc ataaggtcag gagatcaaga ccatcctggc taacacggtg 3240 aaaccccgtc tctactaaaa gtacaaaaaa ttagctgggt gtggtggtgg gcgcctgtag 3300 tcccagctac tcgggaggct gaggcaggag aatcgcttga acctgagagg cggaggttgc 3360 agtgagccaa aattgcacca ctgcacactg cactccatcc tgggcgacag tctgagactc 3420 tgtctcaaaa aaaaaaaaaa aaaaaagaaa cttcagttaa cagcctcctt ggtgctttaa 3480 gcattcagct tccttcaggc tggtaattta tataatccct gaaacgggct tcaggtcaaa 3540 cccttaagac atctgaagct gcaacctggc ctttggtgtt gaaataggaa ggtttaagga 3600 gaatctaagc attttagact tttttttata aatagactta ttttcctttg taatgtattg 3660 gccttttagt gagtaaggct gggcagaggg tgcttacaac cttgactccc tttctccctg 3720 gacttgatct gctgtttcag aggctaggtt gtttctgtgg gtgccttatc agggctggga 3780 tacttctgat tctggcttcc ttcctgcccc accctcccga ccccagtccc cctgatcctg 3840 ctagaggcat gtctccttgc gtgtctaaag gtccctcatc ctgtttgttt taggaatcct 3900 ggtctcagga cctcatggaa gaagaggggg agagagttac aggttggaca tgatgcacac 3960 tatggggccc cagcgacgtg tctggttgag ctcagggaat atggttctta gccagtttct 4020 tggtgatatc cagtggcact tgtaatggcg tcttcattca gttcatgcag ggcaaaggct 4080 tactgataaa cttgagtctg ccctcgtatg agggtgtata cctggcctcc ctctgaggct 4140 ggtgactcct ccctgctggg gccccacagg tgaggcagaa cagctagagg gcctccccgc 4200 ctgcccgcct tggctggcta gctcgcctct cctgtgcgta tgggaacacc tagcacgtgc 4260 tggatgggct gcctctgact cagaggcatg gccggatttg gcaactcaaa accaccttgc 4320 ctcagctgat cagagtttct gtggaattct gtttgttaaa tcaaattagc tggtctctga 4380 attaaggggg agacgacctt ctctaagatg aacagggttc gccccagtcc tcctgcctgg 4440 agacagttga tgtgtcatgc agagctctta cttctccagc aacactcttc agtacataat 4500 aagcttaact gataaacaga atatttagaa aggtgagact tgggcttacc attgggttta 4560 aatcataggg acctagggcg agggttcagg gcttctctgg agcagatatt gtcaagttca 4620 tggccttagg tagcatgtat ctggtcttaa ctctgattgt agcaaaagtt ctgagaggag 4680 ctgagccctg ttgtggccca ttaaagaaca gggtcctcag gccctgcccg cttcctgtcc 4740 actgccccct ccccatcccc agcccagccg agggaatccc gtgggttgct tacctaccta 4800 taaggtggtt tataagctgc tgtcctggcc actgcattca aattccaatg tgtacttcat 4860 agtgtaaaaa tttatattat tgtgaggttt tttgtctttt tttttttttt ttttttttgg 4920 tatattgctg tatctacttt aacttccaga aataaacgtt atataggaac cgtaaaaa 4978 <210> 265 <211> 3868 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3868) <223> STC1 mRNA <400> 265 agtttgcaaa agccagaggt gcaagaagca gcgactgcag cagcagcagc agcagcggcg 60 gtggcagcag cagcagcagc ggcggcagca gcagcagcag cggaggcacc ggtggcagca 120 gcagcatcac cagcaacaac aacaaaaaaa aatcctcatc aaatcctcac ctaagctttc 180 agtgtatcca gatccacatc ttcactcaag ccaggagagg gaaagaggaa aggggggcag 240 gaaaaaaaaa aaacccaaca acttagcgga aacttctcag agaatgctcc aaaactcagc 300 agtgcttctg gtgctggtga tcagtgcttc tgcaacccat gaggcggagc agaatgactc 360 tgtgagcccc aggaaatccc gagtggcggc tcaaaactca gctgaagtgg ttcgttgcct 420 caacagtgct ctacaggtcg gctgcggggc ttttgcatgc ctggaaaact ccacctgtga 480 cacagatggg atgtatgaca tctgtaaatc cttcttgtac agcgctgcta aatttgacac 540 tcagggaaaa gcattcgtca aagagagctt aaaatgcatc gccaacgggg tcacctccaa 600 ggtcttcctc gccattcgga ggtgctccac tttccaaagg atgattgctg aggtgcagga 660 agagtgctac agcaagctga atgtgtgcag catcgccaag cggaaccctg aagccatcac 720 tgaggtcgtc cagctgccca atcacttctc caacagatac tataacagac ttgtccgaag 780 cctgctggaa tgtgatgaag acacagtcag cacaatcaga gacagcctga tggagaaaat 840 tgggcctaac atggccagcc tcttccacat cctgcagaca gaccactgtg cccaaacaca 900 cccacgagct gacttcaaca ggagacgcac caatgagccg cagaagctga aagtcctcct 960 caggaacctc cgaggtgagg aggactctcc ctcccacatc aaacgcacat cccatgagag 1020 tgcataacca gggagaggtt attcacaacc tcaccaaact agtatcattt taggggtgtt 1080 gacacaccag ttttgagtgt actgtgcctg gtttgatttt tttaaagtag ttcctatttt 1140 ctatccccct taaagaaaat tgcatgaaac taggcttctg taatcaatat cccaacattc 1200 tgcaatggca gcattcccac caacaaaatc catgtgacca ttctgcctct cctcaggaga 1260 aagtaccctc ttttaccaac ttcctctgcc atgtttttcc cctgctcccc tgagaccacc 1320 cccaaacaca aaacattcat gtaactctcc agccattgta atttgaagat gtggatccct 1380 ttagaacggt tgccccagta gagttagctg ataaggaaac tttatttaaa tgcatgtctt 1440 aaatgctcat aaagatgtta aatggaattc gtgttatgaa tctgtgctgg ccatggacga 1500 atatgaatgt cacatttgaa ttcttgatct ctaatgagct agtgtcttat ggtcttgatc 1560 ctccaatgtc taattttctt tccgacacat ttaccaaatt gcttgagcct ggctgtccaa 1620 ccagactttg agcctgcatc ttcttgcatc taatgaaaaa caaaaagcta acatctttac 1680 gtactgtaac tgctcagagc tttaaaagta tctttaacaa ttgtcttaaa accagagaat 1740 cttaaggtct aactgtggaa tataaatagc tgaaaactaa tgtactgtac ataaattcca 1800 gaggactctg cttaaacaaa gcagtatata ataactttat tgcatataga tttagttttg 1860 taacttagct ttatttttct tttcctggga atggaataac tatctcactt ccagatatcc 1920 acataaatgc tccttgtggc cttttttata actaaggggg tagaagtagt tttaattcaa 1980 catcaaaact taagatgggc ctgtatgaga caggaaaaac caacaggttt atctgaagga 2040 ccccaggtaa gatgttaatc tcccagccca cctcaaccca gaggctactc ttgacttaga 2100 cctatactga aagatctctg tcacatccaa ctggaaattc caggaaccaa aaagagcatc 2160 cctatgggct tggaccactt acagtgtgat aaggcctact atacattagg aagtggcagt 2220 tctttactcg tcccctttca tcggtgcctg gtactctggc aaatgatgat ggggtgggag 2280 actttccatt aaatcaatca ggaatgagtc aatcagcctt taggtcttta gtccggggga 2340 cttggggctg agagagtata aataaccctg ggctgtccag ccttaataga cttctcttac 2400 attttcgtcc tgtagcacgc tgcctgccaa agtagtcctg gcagctggac catctctgta 2460 ggatcgtaaa aaaatagaaa aaaagaaaaa aaaaagaaag aaagagggaa aaagagctgg 2520 tggtttgatc atttctgcca tgatgtttac aagatggcga ccaccaaagt caaacgacta 2580 acctatctat gaacaacagt agtttctcag ggtcactgtc cttgaaccca acagtccctt 2640 atgagcgtca ctgcccacca aaggtcaatg tcaagagagg aagagaggga ggaggggtag 2700 gactgcaggg gccactccaa actcgcttag gtagaaacta ttggtgcttg actctcacta 2760 ggctaaactc aagatttgac caaatcgagt gatagggatc ctggtgggag gagagagggc 2820 acatctccag aaaaatgaaa agcaatacaa ctttaccata aagcctttaa aaccagtaac 2880 gtgctgctca aggaccaaga gcaattgcag cagacccagc agcagcagca gcagcacaaa 2940 cattgctgcc tttgtcccca cacagcctct aagcgtgctg acatcagatt gttaagggca 3000 tttttatact cagaactgtc ccatccccag gtccccaaac ttatggacac tgccttagcc 3060 tcttggaaat caggtagacc atattctaag ttagactctt cccctccctc ccacacttcc 3120 cacccccagg caaggctgac ttctctgaat cagaaaagct attaaagttt gtgtgttgtg 3180 tccattttgc aaacccaact aagccaggac cccaatgcga caagtagttc atgagtattc 3240 ctagcaaatt tctctctttc ttcagttcag tagatttcct tttttctttt cttttttttt 3300 tttttttttt ttggctgtga cctcttcaaa ccgtggtacc cccccttttc tccccacgat 3360 gatatctata tatgtatcta caatacatat atctacacat acagaaagaa gcagttctca 3420 caatgttgct agttttttgc ttctctttcc cccaccctac tccctccaat tcccccttaa 3480 acttccaaag cttcgtcttg tgtttgctgc agagtgattc gggggctgac ctagaccagt 3540 ttgcatgatt cttctcttgt gatttggttg cactttagac atttttgtgc cattatattt 3600 gcattatgta tttataattt aaatgatatt taggtttttg gctgagtact ggaataaaca 3660 gtgagcatat ctggtatatg tcattattta ttgttaaatt acatttttaa gctccatgtg 3720 catataaagg ttatgaaaca tatcatggta atgacagatg caagttattt tatttgctta 3780 tttttataat taaagatgcc atagcataat atgaagcctt tggtgaattc cttctaagat 3840 aaaaataata ataaagtgtt acgtttta 3868 <210> 266 <211> 2613 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2613) <223> SDC4 mRNA <400> 266 actcgccgca gcctgcgcgc cttctccagt ccgcggtgcc atggcccccg cccgtctgtt 60 cgcgctgctg ctgttcttcg taggcggagt cgccgagtcg atccgagaga ctgaggtcat 120 cgacccccag gacctcctag aaggccgata cttctccgga gccctaccag acgatgagga 180 tgtagtgggg cccgggcagg aatctgatga ctttgagctg tctggctctg gagatctgga 240 tgacttggaa gactccatga tcggccctga agttgtccat cccttggtgc ctctagataa 300 ccatatccct gagagggcag ggtctgggag ccaagtcccc accgaaccca agaaactaga 360 ggagaatgag gttatcccca agagaatctc acccgttgaa gagagtgagg atgtgtccaa 420 caaggtgtca atgtccagca ctgtgcaggg cagcaacatc tttgagagaa cggaggtcct 480 ggcagctctg attgtgggtg gcatcgtggg catcctcttt gccgtcttcc tgatcctact 540 gctcatgtac cgtatgaaga agaaggatga aggcagctat gacctgggca agaaacccat 600 ctacaagaaa gcccccacca atgagttcta cgcgtgaagc ttgcttgtgg gcactggctt 660 ggactttagc ggggagggaa gccaggggat tttgaagggt ggacattagg gtagggtgag 720 gtcaacctaa tactgacttg tcagtatctc cagctctgat tacctttgaa gtgttcagaa 780 gagacattgt cttctactgt tctgccaggt tcttcttgag ctttgggcct cagttgccct 840 ggcagaaaaa tggattcaac ttggcctttc tgaaggcaag actgggattg gatcacttct 900 taaacttcca gttaagaatc taggtccgcc ctcaagccca tactgaccat gcctcatcca 960 gagctcctct gaagccaggg ggctaacgga tgttgtgtgg agtcctggct ggaggtcctc 1020 ccccagtggc cttcctccct tcctttcaca gccggtctct ctgccaggaa atgggggaag 1080 gaactagaac cacctgcacc ttgagatgtt tctgtaaatg ggtacttgtg atcacactac 1140 gggaatctct gtggtatata cctggggcca ttctaggctc tttcaagtga cttttggaaa 1200 tcaacctttt ttatttgggg gggaggatgg ggaaaagagc tgagagttta tgctgaaatg 1260 gatttataga atatttgtaa atctattttt agtgtttgtt cgttttttta actgttcatt 1320 cctttgtgca gagtgtatat ctctgcctgg gcaagagtgt ggaggtgccg aggtgtcttc 1380 attctctcgc acatttccac agcacctgct aagtttgtat ttaatggttt ttgtttttgt 1440 ttttgtttgt ttcttgaaaa tgagagaaga gccggagaga tgatttttat taattttttt 1500 tttttttttt tttttttact atttatagct ttagataggg cctcccttcc cctcttcttt 1560 ctttgttctc tttcattaaa ccccttcccc agtttttttt ttatacttta aaccccgctc 1620 ctcatggcct tggccctttc tgaagctgct tcctcttata aaatagcttt tgccgaaaca 1680 tagttttttt ttagcagatc ccaaaatata atgaagggga tggtgggata tttgtgtctg 1740 tgttcttata atatattatt attcttcctt ggttctagaa aaatagataa atatattttt 1800 ttcaggaaat agtgtggtgt ttccagtttg atgttgctgg gtggttgagt gagtgaattt 1860 tcatgtggct gggtgggttt ttgccttttt ctcttgccct gttcctggtg ccttctgatg 1920 gggctggaat agttgaggtg gatggttcta ccctttctgc cttctgtttg ggacccagct 1980 ggtgttcttt ggtttgcttt cttcaggctc tagggctgtg ctatccaata cagtaaccac 2040 atgcggctgt ttaaagttaa gccaattaaa atcacataag attaaaaatt ccttcctcag 2100 ttgcactaac cacgtttcta gaggcgtcac tgtatgtagt tcatggctac tgtactgaca 2160 gcgagagcat gtccatctgt tggacagcac tattctagag aactaaactg gcttaacgag 2220 tcacagcctc agctgtgctg ggacgaccct tgtctccctg ggtagggggg ggggaatggg 2280 ggagggctga tgaggcccca gctggggcct gttgtctggg accctccctc tcctgagagg 2340 ggaggcctgg tggcttagcc tgggcaggtc gtgtctcctc ctgaccccag tggctgcggt 2400 gaggggaacc accctccctt gctgcaccag tggccattag ctcccgtcac cactgcaacc 2460 cagggtccca gctggctggg tcctcttctg cccccagtgc ccttcccctt gggctgtgtt 2520 ggagtgagca cctcctctgt aggcacctct cacactgttg tctgttactg attttttttg 2580 ataaaaagat aataaaacct ggtactttct aaa 2613 <210> 267 <211> 4260 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4260) <223> TAGLN mRNA <400> 267 cgaggagcga gccagtgggg gaggctgaca tcaccacggc ggcagccctt taaacccctc 60 acccagccag cgccccatcc tgtctgtccg aacccagaca caagtcttca ctccttcctg 120 cgagccctga ggaagccttg tgagtgcatt ggctggggct tggagggaag ttgggctgga 180 gctggacagg agcagtgggt gcatttcagg caggctctcc tgaggtccca ggcgccagct 240 ccagctccct ggctagggaa acccaccctc tcagtcagca tgggggccca agctccaggc 300 agggtgggct ggatcactag cgtcctggat ctctctcaga ctgggcagcc ccgggctcat 360 tgaaatgccc cggatgactt ggctagtgca gaggaattga tggaaaccac cggggtgaga 420 gggaggctcc ccatctcagc cagccacatc cacaaggtgt gtgtaagggt gcaggcgccg 480 gccggttagg ccaaggctct actgtctgtt gcccctccag gagaacttcc aaggagcttt 540 ccccagacat ggccaacaag ggtccttcct atggcatgag ccgcgaagtg cagtccaaaa 600 tcgagaagaa gtatgacgag gagctggagg agcggctggt ggagtggatc atagtgcagt 660 gtggccctga tgtgggccgc ccagaccgtg ggcgcttggg cttccaggtc tggctgaaga 720 atggcgtgat tctgagcaag ctggtgaaca gcctgtaccc tgatggctcc aagccggtga 780 aggtgcccga gaacccaccc tccatggtct tcaagcagat ggagcaggtg gctcagttcc 840 tgaaggcggc tgaggactat ggggtcatca agactgacat gttccagact gttgacctct 900 ttgaaggcaa agacatggca gcagtgcaga ggaccctgat ggctttgggc agcttggcag 960 tgaccaagaa tgatgggcac taccgtggag atcccaactg gtttatgaag aaagcgcagg 1020 agcataagag ggaattcaca gagagccagc tgcaggaggg aaagcatgtc attggccttc 1080 agatgggcag caacagaggg gcctcccagg ccggcatgac aggctacgga cgacctcggc 1140 agatcatcag ttagagcgga gagggctagc cctgagcccg gccctccccc agctccttgg 1200 ctgcagccat cccgcttagc ctgcctcacc cacacccgtg tggtaccttc agccctggcc 1260 aagctttgag gctctgtcac tgagcaatgg taactgcacc tgggcagctc ctccctgtgc 1320 ccccagcctc agcccaactt cttacccgaa agcatcactg ccttggcccc tccctcccgg 1380 ctgcccccat cacctctact gtctcctccc tgggctaagc aggggagaag cgggctgggg 1440 gtagcctgga tgtgggccaa gtccactgtc ctccttggcg gcaaaagccc attgaagaag 1500 aaccagccca gcctgccccc tatcttgtcc tggaatattt ttggggttgg aactcaaaaa 1560 aaaaaaaaaa aaatcaatct tttctcaggc ctggctggca gagtttgatt tgccctggtc 1620 acttttgtta tggtttcaga tctgcgcagg ggacaggcag gcatctcggg cttgtatgtg 1680 ttcctggctg ccgtcctctg aaggaccctt catgtgccaa gattccagga cagtcagatt 1740 ctttcagagg aaacaggcca tagaacagga gagtgaatct tggggaccga agggaaaaag 1800 gagccactca gcagcatgca gtggctttgg ggagacagag gaaaggagag attgcgagtg 1860 gcagaattgt ttggaaggtt tttattttgg aaaagctgtg cagaaaaaaa ttcaagaaaa 1920 tgttgctgtg aaaagagaaa aacaaatctt aagcattaaa aaaaattcaa ccaactagct 1980 cagaagaggg gagaaggcca aggttgagag aagagtcaca gcctgtcagg cagatagctg 2040 gcctccggcg ggaaggccat ttccctgagc acttgcagag gaagacaggg tggtggcagg 2100 actggagtgg cagtggctcc caaggctctc tcctccaaca tgtgcatctg ccatctgctc 2160 tgcagtcctg ccgcaggatt ccctagtgaa gcagctcagg cctgggggag ccgtgtgtat 2220 cccagctgtg ccggcagcat cataccaatc gtgggggtgg tgaaggagcc aggggttcat 2280 tcatggttgg tttctgatca ggcatcttgg gaatggataa tggaggcagc cgctttcagg 2340 acaggcatgt ccaggggctc ctcccagcct ctaccccgaa gtcctcttcc caagtgaccc 2400 cagtgatgtt tccattgaga tgcgctcctg gctatggcag gcaccttctc aacttatatg 2460 tgggaagggg tcccccatgc ttgggggacc taggcagctg gcttggccca agagagatga 2520 ggatggaggc caaaccaaag gggggcgcca atcccctgtc caacaccttc tcaccaaaag 2580 ctcccgtttg gctggaggca gaccctgtgg ctctgaccag acttctctgg cagcaatcct 2640 ccaccatttg tatcttaaga aggccctcac cctctttgag tggagtcaga ggatgcctca 2700 gattccagat gtaagcatca gaactgcttt ctgtcaagag ctccctaatt ttgggaaaga 2760 agagcctgtc ccacactgtc aggccctgag gtcagcagat ctgctcctcc ttcccgtgcg 2820 gtacgtctag gtgctgatga gggcagtcca gggcgctctt gttctgggac aggctccagt 2880 ccccttgctc cagcaggtct ggggcaagga ggtcagaggt ggtgggaggg cccctgctct 2940 ctgtttccac ttcgtctgga tccttgctgc tgcaaagtgg cactgattct agctctgtcc 3000 cttcctcctt ggctttccgg ctccgatggg gccagtggca gggtccactc ctacaaactt 3060 gattggaagc cacattcctc tggctcaaat atacttccag catgtagtaa acagtccaga 3120 agacggtgaa acagcctacc agcaccaggg tctggggccg aggcaagcac ctacgtgagg 3180 cactgtttcc cgaagcctac agcctttctc agcccaggac aatgagctca gaaagtcttt 3240 ttccttctag ggactgcctt tttcacccaa actgttccct ctgccccctc ccccgacaag 3300 gcctgtcctg taagagttag gctagcaggg taggagcaat gctatgaaac cactgctggg 3360 acccaggtct tcccagtcct tcaccccgca ggtcaccctg agaaacacac taagaactcc 3420 atcccccaga caggacagtc ccatctaccc gcagcttgag tcttggccct agtaccttga 3480 gggtgttggg ggtgatggtg taaccatctt cctcaggaat tttcagcccc ggtgggcagg 3540 gcagggcgaa gtcatcgtgc aggtattttc cactcatggc actctctaac agcctgtgga 3600 gaagaaaaga ggtgaggatg ccccactgac tatggttcct ataccatctg ccctcaccca 3660 ttttcctgcc ttacaggtga agacagggaa gccccacagc aaaaaggaga ggcccagact 3720 gtgagttccc agcccggggc tccatctacc ggcttgacgc tggaactggg aagcacagct 3780 ggggttcaga gggcgatggg ctccctaggc ggcccttccc ctgtgactgg ccttccctct 3840 gacacatgcg gctttaccca cctttgtctg tccctgatgt ctactgcact ccacacagag 3900 ccatataggg tcagctgcca ttgccggagg atgccgacct ggaatgactc atcccctagg 3960 gcagcaaggg gcagctcgtg agccacgccc ctctgtcagc catgccagac agcagaggcc 4020 ctgcccgccc tgccacccaa aggggctcag gccacatggt ctgctccagg agctgcctca 4080 ctgtgtccca ctgaccccag gttctgcaga agggcctcac tgggtgccct tagggatgga 4140 aagggttgaa aggctgtact ccaaagcaga gtcttgcttt tctctcccgt attttggggg 4200 ttcagctggg attagaaaaa aatgtctttc caccaaatta aagaaagctt tgaaaaccac 4260 4260 <210> 268 <211> 2444 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2444) <223> TFPI2 mRNA <400> 268 attactgaca caaacgctcc ctcagggcgt ccccgtctgg actacaggag aaagtttggg 60 aggcaggttc aacttttcaa cttggcgggg aattcctctc cctcttacac agtttgcagc 120 gcgggggcgg cggggtgaca gtccccgtgc atgaatcagc cacccctcag gctccgcccc 180 ggcgggggtc ggccggacgc tcgccccgca taaagcgggc acccgggccg cctggagcag 240 aaagccgcgc acctcctccc gccaggcgct ttctcggacg ccttgcccag cgggccgccc 300 gaccccctgc accatggacc ccgctcgccc cctggggctg tcgattctgc tgcttttcct 360 gacggaggct gcactgggcg atgctgctca ggagccaaca ggaaataacg cggagatctg 420 tctcctgccc ctagactacg gaccctgccg ggccctactt ctccgttact actacgacag 480 gtacacgcag agctgccgcc agttcctgta cgggggctgc gagggcaacg ccaacaattt 540 ctacacctgg gaggcttgcg acgatgcttg ctggaggata gaaaaagttc ccaaagtttg 600 ccggctgcaa gtgagtgtgg acgaccagtg tgaggggtcc acagaaaagt atttctttaa 660 tctaagttcc atgacatgtg aaaaattctt ttccggtggg tgtcaccgga accggattga 720 gaacaggttt ccagatgaag ctacttgtat gggcttctgc gcaccaaaga aaattccatc 780 attttgctac agtccaaaag atgagggact gtgctctgcc aatgtgactc gctattattt 840 taatccaaga tacagaacct gtgatgcttt cacctatact ggctgtggag ggaatgacaa 900 taactttgtt agcagggagg attgcaaacg tgcatgtgca aaagctttga aaaagaaaaa 960 gaagatgcca aagcttcgct ttgccagtag aatccggaaa attcggaaga agcaatttta 1020 aacattctta atatgtcatc ttgtttgtct ttatggctta tttgccttta tggttgtatc 1080 tgaagaataa tatgacagca tgaggaaaca aatcattggt gatttattca ccagttttta 1140 ttaatacaag tcacttttta aaaaatttgg atttttttat atataactag ctgctattca 1200 aatgtgagtc taccattttt aatttatggt tcaactgttt gtgagactga attcttgcaa 1260 tgcataagat ataaaagcaa atatgactca ctcatttctt ggggtcgtat tcctgatttc 1320 agaagaggat cataactgaa acaacataag acaatataat catgtgcttt taacatattt 1380 gagaataaaa aggactagca aataaaactc attttgcatt taaaagttgg attatatttt 1440 agtcccaaga agacaaagtc gcagattaac aacactttaa aaatattact cccattttat 1500 tgtgttagat tgcagtacaa tgaatgaata aggggattta tttaaaagat cttaactttc 1560 ttgactgatt taaaaagcta atcaatttat taaagccaga aatgttctcc tctgggaaag 1620 caatttctat ctatttatct accaatcccc actcacatgt atatgtttgt gtttacatag 1680 agatagatgg ttttaagggt tttcctattg ttaaattatt tcctaagaca ttgtgggttg 1740 gagaccacta aacttataaa aaaccaagga aagtaaagtt tttcaaatgt ttatactgtt 1800 taaggtgttt atttatataa accatgcatg agaaaccatg cataaattta ataatttaaa 1860 tttcaccagt aaattatcat tgattaaata tggtcatacc aatgaaatag gttttttctt 1920 tctctgtaat aaaacaattt ttctaaattc ttatgttttc atagcaagat taacatattt 1980 aattacaaat taaatatgca aaatgacaaa tgcgtttacc ttttgcttga acaatctttc 2040 atttaaaaat ttatcccagt tattttgaca aataggtata tgcctgagaa ctttgaatga 2100 tgctgaaagc tagaagcaaa ccaggtactc ttcagtcagg gactggttga agattttatg 2160 gatgaggagt tagcaaaata tctatatatg catatcttct gactcccagg atacataaga 2220 aacacagggc ctagaacagt atgaataaac acacatatac acaaacatca cagaagatac 2280 taaagatatt aaaaatgttt acctatagag gtttggagag aacagagggg tggacagttg 2340 tggagataat atttgtgtaa atataactgt gatatagttt ttatcttgga ccatgtaaat 2400 atttgacata attaataatc aaaattaaat aaaaaagaaa aagc 2444 <210> 269 <211> 2741 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2741) <223> TGFB1 mRNA <400> 269 acctccctcc gcggagcagc cagacagcga gggccccggc cgggggcagg ggggacgccc 60 cgtccggggc acccccccgg ctctgagccg cccgcggggc cggcctcggc ccggagcgga 120 ggaaggagtc gccgaggagc agcctgaggc cccagagtct gagacgagcc gccgccgccc 180 ccgccactgc ggggaggagg gggaggagga gcgggaggag ggacgagctg gtcgggagaa 240 gaggaaaaaa acttttgaga cttttccgtt gccgctggga gccggaggcg cggggacctc 300 ttggcgcgac gctgccccgc gaggaggcag gacttgggga ccccagaccg cctccctttg 360 ccgccgggga cgcttgctcc ctccctgccc cctacacggc gtccctcagg cgcccccatt 420 ccggaccagc cctcgggagt cgccgacccg gcctcccgca aagacttttc cccagacctc 480 gggcgcaccc cctgcacgcc gccttcatcc ccggcctgtc tcctgagccc ccgcgcatcc 540 tagacccttt ctcctccagg agacggatct ctctccgacc tgccacagat cccctattca 600 agaccaccca ccttctggta ccagatcgcg cccatctagg ttatttccgt gggatactga 660 gacacccccg gtccaagcct cccctccacc actgcgccct tctccctgag gacctcagct 720 ttccctcgag gccctcctac cttttgccgg gagaccccca gcccctgcag gggcggggcc 780 tccccaccac accagccctg ttcgcgctct cggcagtgcc ggggggcgcc gcctccccca 840 tgccgccctc cgggctgcgg ctgctgccgc tgctgctacc gctgctgtgg ctactggtgc 900 tgacgcctgg ccggccggcc gcgggactat ccacctgcaa gactatcgac atggagctgg 960 tgaagcggaa gcgcatcgag gccatccgcg gccagatcct gtccaagctg cggctcgcca 1020 gccccccgag ccagggggag gtgccgcccg gcccgctgcc cgaggccgtg ctcgccctgt 1080 acaacagcac ccgcgaccgg gtggccgggg agagtgcaga accggagccc gagcctgagg 1140 ccgactacta cgccaaggag gtcacccgcg tgctaatggt ggaaacccac aacgaaatct 1200 atgacaagtt caagcagagt acacacagca tatatatgtt cttcaacaca tcagagctcc 1260 gagaagcggt acctgaaccc gtgttgctct cccgggcaga gctgcgtctg ctgaggctca 1320 agttaaaagt ggagcagcac gtggagctgt accagaaata cagcaacaat tcctggcgat 1380 acctcagcaa ccggctgctg gcacccagcg actcgccaga gtggttatct tttgatgtca 1440 ccggagttgt gcggcagtgg ttgagccgtg gaggggaaat tgagggcttt cgccttagcg 1500 cccactgctc ctgtgacagc agggataaca cactgcaagt ggacatcaac gggttcacta 1560 ccggccgccg aggtgacctg gccaccattc atggcatgaa ccggcctttc ctgcttctca 1620 tggccacccc gctggagagg gcccagcatc tgcaaagctc ccggcaccgc cgagccctgg 1680 acaccaacta ttgcttcagc tccacggaga agaactgctg cgtgcggcag ctgtacattg 1740 acttccgcaa ggacctcggc tggaagtgga tccacgagcc caagggctac catgccaact 1800 tctgcctcgg gccctgcccc tacatttgga gcctggacac gcagtacagc aaggtcctgg 1860 ccctgtacaa ccagcataac ccgggcgcct cggcggcgcc gtgctgcgtg ccgcaggcgc 1920 tggagccgct gcccatcgtg tactacgtgg gccgcaagcc caaggtggag cagctgtcca 1980 acatgatcgt gcgctcctgc aagtgcagct gaggtcccgc cccgccccgc cccgccccgg 2040 caggcccggc cccaccccgc cccgcccccg ctgccttgcc catgggggct gtatttaagg 2100 acacccgtgc cccaagccca cctggggccc cattaaagat ggagagagga ctgcggatct 2160 ctgtgtcatt gggcgcctgc ctggggtctc catccctgac gttcccccac tcccactccc 2220 tctctctccc tctctgcctc ctcctgcctg tctgcactat tcctttgccc ggcatcaagg 2280 cacaggggac cagtggggaa cactactgta gttagatcta tttattgagc accttgggca 2340 ctgttgaagt gccttacatt aatgaactca ttcagtcacc atagcaacac tctgagatgc 2400 agggactctg ataacaccca ttttaaaggt gaggaaacaa gcccagagag gttaagggag 2460 gagttcctgc ccaccaggaa cctgctttag tgggggatag tgaagaagac aataaaagat 2520 agtagttcag gccaggcggg gtggctcacg cctgtaatcc tagcactttt gggaggcaga 2580 gatgggagga ttacttgaat ccaggcattt gagaccagcc tgggtaacat agtgagaccc 2640 tatctctaca aaacactttt aaaaaatgta cacctgtggt cccagctact ctggaggcta 2700 aggtgggagg atcacttgat cctgggaggt caaggctgca g 2741 <210> 270 <211> 6339 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6339) <223> TGFBR3 mRNA <400> 270 aatcgagggt ttcggggacg ccgagcggca ctttcctctt cccagcgagt gaaggagggc 60 agtcggcggc tctcgcgccc cggccacttt ccctgcgcga ttcccggagc tccctgcagg 120 aggtgagagt ccccagcggg tccggatggc gtagttttgc cgcggcgcag cagctgccgg 180 agctcgccgc cgccgagcgc tgggcgggga aacttgccgc cgctttcctc caacttgctg 240 cgggtggatc tccgctggac acaccgcctc cgaggcagtt tgaaaattgc aaggagggac 300 tttaagacta cttctgattt gcaaagattg tctgtgctct gagcaggctg aagtgactgg 360 acgagacgca ctgttggaga aataaaaatg acttcccatt atgtgattgc catctttgcc 420 ctgatgagct cctgtttagc cactgcaggt ccagagcctg gtgcactgtg tgaactgtca 480 cctgtcagtg cctcccatcc tgtccaggcc ttgatggaga gcttcactgt tttgtcaggc 540 tgtgccagca gaggcacaac tgggctgcca caggaggtgc atgtcctgaa tctccgcact 600 gcaggccagg ggcctggcca gctacagaga gaggtcacac ttcacctgaa tcccatctcc 660 tcagtccaca tccaccacaa gtctgttgtg ttcctgctca actccccaca ccccctggtg 720 tggcatctga agacagagag acttgccact ggggtctcca gactgttttt ggtgtctgag 780 ggttctgtgg tccagttttc atcagcaaac ttctccttga cagcagaaac agaagaaagg 840 aacttccccc atggaaatga acatctgtta aattgggccc gaaaagagta tggagcagtt 900 acttcattca ccgaactcaa gatagcaaga aacatttata ttaaagtggg ggaagatcaa 960 gtgttccctc caaagtgcaa catagggaag aattttctct cactcaatta ccttgctgag 1020 taccttcaac ccaaagcagc agaagggtgt gtgatgtcca gccagcccca gaatgaggaa 1080 gtacacatca tcgagctaat cacccccaac tctaacccct acagtgcttt ccaggtggat 1140 ataacaattg atataagacc ttctcaagag gatcttgaag tggtcaaaaa tctcatcctg 1200 atcttgaagt gcaaaaagtc tgtcaactgg gtgatcaaat cttttgatgt taagggaagc 1260 ctgaaaatta ttgctcctaa cagtattggc tttggaaaag agagtgaaag atctatgaca 1320 atgaccaaat caataagaga tgacattcct tcaacccaag ggaatctggt gaagtgggct 1380 ttggacaatg gctatagtcc aataacttca tacacaatgg ctcctgtggc taatagattt 1440 catcttcggc ttgaaaataa tgcagaggag atgggagatg aggaagtcca cactattcct 1500 cctgagctac ggatcctgct ggaccctggt gccctgcctg ccctgcagaa cccgcccatc 1560 cggggagggg aaggccaaaa tggaggcctt ccgtttcctt tcccagatat ttccaggaga 1620 gtctggaatg aagagggaga agatgggctc cctcggccaa aggaccctgt cattcccagc 1680 atacaactgt ttcctggtct cagagagcca gaagaggtgc aagggagcgt ggatattgcc 1740 ctgtctgtca aatgtgacaa tgagaagatg atcgtggctg tagaaaaaga ttcttttcag 1800 gccagtggct actcggggat ggacgtcacc ctgttggatc ctacctgcaa ggccaagatg 1860 aatggcacac actttgtttt ggagtctcct ctgaatggct gcggtactcg gccccggtgg 1920 tcagcccttg atggtgtggt ctactataac tccattgtga tacaggttcc agcccttggg 1980 gacagtagtg gttggccaga tggttatgaa gatctggagt caggtgataa tggatttccg 2040 ggagatatgg atgaaggaga tgcttccctg ttcacccgac ctgaaatcgt ggtgtttaat 2100 tgcagccttc agcaggtgag gaaccccagc agcttccagg aacagcccca cggaaacatc 2160 accttcaaca tggagctata caacactgac ctctttttgg tgccctccca gggcgtcttc 2220 tctgtgccag agaatggaca cgtttatgtt gaggtatctg ttactaaggc tgaacaagaa 2280 ctgggatttg ccatccaaac gtgctttatc tctccatatt cgaaccctga taggatgtct 2340 cattacacca ttattgagaa tatttgtcct aaagatgaat ctgtgaaatt ctacagtccc 2400 aagagagtgc actttcctat cccgcaagct gacatggata agaagcgatt cagctttgtc 2460 ttcaagcctg tcttcaacac ctcactgctc tttctacagt gtgagctgac gctgtgtacg 2520 aagatggaga agcaccccca gaagttgcct aagtgtgtgc ctcctgacga agcctgcacc 2580 tcgctggacg cctcgataat ctgggccatg atgcagaata agaagacgtt cactaagccc 2640 cttgctgtga tccaccatga agcagaatct aaagaaaaag gtccaagcat gaaggaacca 2700 aatccaattt ctccaccaat tttccatggt ctggacaccc taaccgtgat gggcattgcg 2760 tttgcagcct ttgtgatcgg agcactcctg acgggggcct tgtggtacat ctattctcac 2820 acaggggaga cagcaggaag gcagcaagtc cccacctccc cgccagcctc ggaaaacagc 2880 agtgctgccc acagcatcgg cagcacgcag agcacgcctt gctccagcag cagcacggcc 2940 tagcccaacc cagcccaacc cggcccaacc cagcccagcc cagctcagct cagctactgc 3000 caagggcagg accaatggct gagcctcgtg tccagactca gagggctgga ttttggttcc 3060 cttgtaaaga cagagtgaat ttcagtataa agatcacccg ttgtattcac cccacaccca 3120 gggctagtat aaacatgacc ctgggcttct gtaccacact agaattcatg tgagaaagct 3180 aaaatggtgg tcttctccac cagcccctca caggcttggg ggttttcaat gtgaaacaca 3240 tgccagtttt taaaatgctg ctttgtccag gtgagaacat ccataatttg gggccctgag 3300 ttttacccag actcaaggag ttggtaaagg gttaatagcc agatagtaga accagtgagg 3360 agatgcggcc aaagattctt tatatctgaa ccaagatgta aaacaagaaa tgctttgagg 3420 ctttctaagc gatcctcctg tctaatttgc acctttgtct ggatgcacac ttctgacctt 3480 gctgccacaa cctgtggggt ctgatgtgtc ccttgatggg tgctgccctc agggactgca 3540 ccctgacaag tgttaaggca acattccttt cttgtgccct gggccaaaac caatgctgat 3600 gaccttatca gcttcctgtt tcttcccata cttgcataca ccactgcaaa atgtcttaat 3660 gcaaattttg tatttcttac aggcctacag aaattgaaaa tgaccaaaat caggaaccac 3720 agatttgtgc ccattcctaa tattttgttc tgcaaattaa tgtataattt gaggtgaaat 3780 tcagttataa agtcaaggac gaatttgcac agtgatatat ttctatgtgt atgcaagtac 3840 aagtatataa tatgtcacct ggcacattca ttttctcagt tgaagaagag aaaatttgaa 3900 aatgtcctta tgcttttaga gttgcaactt aagtatattt ggtagggtga gtgtttccac 3960 tcaaaatatg tcaacttaaa aaaaaatagg ccctttcata aaaaccaaac tgtagcaaga 4020 tgcaaatgca tggcaaatcc tgtcggtctc cagttggtta tctgaatagt gtcaccaatt 4080 ccaccaagac agtgctgaga ttggaaaagg gcactcattt ggattgcctt acttctcttg 4140 ccttaaatat atcccatata tttaatatgt caaaaagggc ttgaggtgaa tttcattaaa 4200 tggaataata tgatgccact ttgcagctaa aataagctca gtgatacctc cttgttaaaa 4260 aaaaaaaaaa aaaaaaagaa tgccaggggg gaattatcat gctaaattat tttactgctg 4320 aagatagctt cattgcaaat tattcttttt ccagaatttc ccccaaacaa cttagaattc 4380 cataagtaga acaagataga ttctaccccc aaaatattca taagcaaatc ccactgccct 4440 taaaataagg aagttatgcc tggttgtctg tgaatggaac ctcagtaggt aatcctgatg 4500 aagcttaaaa ccttagggca gtgtctacat gggaaacaag tatgtggaaa ttgacaatca 4560 tttttaccaa atcgttgagt aataatatga cttacctgat agatatacac attcaataag 4620 gaacattttt ttttttcaat aaggaacatt ttaactaaaa cattacttta gggctgagat 4680 ttccaggcta tctacattga tctactgaaa aatttctaga tttccatata caaacgaaga 4740 agacatgagt ttagagaatt tttttccttt aatttttttt taacagaagg gtatcagagt 4800 ggaggaccta gattacgcta cctgtgtttg aaaatattgc gctttgccta accttcggtg 4860 gaatgtattg tttcagcata ttctatgtat aaaaaagttt aaagatgtct tcaaagaaga 4920 ctagagtctt taagtcactt atagctatat tttactacaa aatttgtgta taaagatata 4980 tttaagtgtt ttagataaat ttaagttact ccatatgaaa tgtttaattt cagctactgt 5040 gaattctttc gatcagtcct ttgctttttt aaaaaatctt ttccatcgtg ttaaaaagaa 5100 aattagctat taggagatat taaaagattg atgtcttaga aggacagggt taaaaccttc 5160 tgtaatatat ttaaatatat atttttaaga gagatgctac attgccaatg attttataaa 5220 taatttaaaa ttaatttaca aatttataga tgcaaaccaa aagatctttt taaaagagag 5280 agagaggaaa aaaatcacct tttatttgtt tgggtctcat tgtcagaatt attattcaga 5340 tcaagaaatc tgtgtcgata aaacctaatc tcatattgga gagtgaatgt cgttaagtat 5400 ttctgaaatg tttctaaaaa atgaacatga aaaaaataag gtattttctc cctagcttct 5460 cattacagta tttctaattg cttcacactt tacagtttta atacaaagta caagctctac 5520 ttttataacg tgtactacaa gtttctttaa aagtattgtt gtatttcagc tgaactcttg 5580 tatctgcagt cttttgttat ttctgcaggc tacaccctta atttgcagag gccattttgt 5640 tgtttgtttg atgctgaagc tgttgttaaa atgccccaaa ctccaaggca gattgtctgt 5700 ataatacgct atagcttttc accatgtggt gtttaccagc tgttactctg tattttaaaa 5760 agccagagat ttcttctgtc taaactgttt ctatagcatt ttctaaacaa aaaaaatggt 5820 ttttttcttt gccttgtaat aagattgtaa atccatttcc tgcttgtgtt cttagtgggc 5880 atgattgtga gtgtgtgtgg ggtgctcaca cgcgtgccag tctttttgta ctgtaactac 5940 ctcatggttt gaatgatgat tgtactgctg gttgtgttaa cagagcacat tttgttgggt 6000 gagtcctatg tgattttttt catgtttgtt ttatctgggg gttgttcatg aaactgacag 6060 atgtttttct aaaaaggact attatcagtt tccaaataca atacttctct cttctggttt 6120 ttcctgaatg agcctgattt tgttgctggt tttcatcatc tatgagggta aaacgagtac 6180 ccttaaaatc cctgtggcca gtttgaacac ccctgttgta ttcttttctc tgttcagtgt 6240 gtcagctatt ttgtgaagat gcttagatgt atagttttga taaccacagt tttaaatctt 6300 ttatctgtgc ataataaaaa gatatatatc agttattaa 6339 <210> 271 <211> 769 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(769) <223> TIMP1 mRNA <400> 271 gccatcgccg cagatccagc gcccagagag acaccagaga acccaccatg gccccctttg 60 agcccctggc ttctggcatc ctgttgttgc tgtggctgat agcccccagc agggcctgca 120 cctgtgtccc accccaccca cagacggcct tctgcaattc cgacctcgtc atcagggcca 180 agttcgtggg gacaccagaa gtcaaccaga ccaccttata ccagcgttat gagatcaaga 240 tgaccaagat gtataaaggg ttccaagcct taggggatgc cgctgacatc cggttcgtct 300 acacccccgc catggagagt gtctgcggat acttccacag gtcccacaac cgcagcgagg 360 agtttctcat tgctggaaaa ctgcaggatg gactcttgca catcactacc tgcagttttg 420 tggctccctg gaacagcctg agcttagctc agcgccgggg cttcaccaag acctacactg 480 ttggctgtga ggaatgcaca gtgtttccct gtttatccat cccctgcaaa ctgcagagtg 540 gcactcattg cttgtggacg gaccagctcc tccaaggctc tgaaaagggc ttccagtccc 600 gtcaccttgc ctgcctgcct cgggagccag ggctgtgcac ctggcagtcc ctgcggtccc 660 agatagcctg aatcctgccc ggagtggaag ctgaagcctg cacagtgtcc accctgttcc 720 cactcccatc tttcttccgg acaatgaaat aaagagttac cacccagca 769 <210> 272 <211> 1876 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1876) <223> TMEM158 mRNA <400> 272 ggggaatcct gctctgggat agcacccggc cccgcagagc agcgcggcag cccaagggcc 60 ccggcgccgg gggcggcggg gaaccccaaa cgcaaccggg tctggaggga tccccgcgcc 120 gagccagccg ccgtcaccgc ctccgcgccg cccctgcggg cttggcaggc gcccggcgcg 180 cccgcactgc gcccggccgc cggctcccgc ggtcccaccg tgagctcgcc ggcccgtcgc 240 ccgctcgcca tgcaaccgcc gccggcctcg cgcgcgtagg cgcccgccgc aggccatgct 300 gcccctgctc gccgcgctcc tggccgccgc ctgcccgctg ccgcccgtcc gcggcggggc 360 cgcggacgcg cccggcctcc tcggggtgcc ctccaatgct tcagtcaacg cgtcctccgc 420 ggacgagccc atcgccccgc ggctgctggc ctcggcggcc cccgggcccc ccgagcgccc 480 gggcccggag gaggcggcgg cggcggcggc gccgtgcaac atcagcgtgc agcggcagat 540 gctgagctcg ctgctcgtgc gctggggccg cccgcggggc ttccagtgcg acctactgct 600 cttctccacc aacgcgcacg gccgcgcttt cttcgccgcc gccttccacc gcgtcgggcc 660 gccgctgctc atcgagcacc tggggctggc ggcgggcggc gcgcagcagg acctgcgcct 720 ctgcgtgggc tgcggctggg tgcgcggtcg ccgcaccggc cgcctccggc ccgccgccgc 780 ccccagcgcc gccgccgcca ccgccggggc gcccaccgcg ctgccagcct accccgcggc 840 cgagccgccc gggccgctgt ggctgcaggg cgagccgctg catttctgct gcctagactt 900 cagcctggag gagctgcagg gcgagccggg ctggcggctg aaccgtaagc ccattgagtc 960 cacgctggtg gcctgcttca tgaccctggt catcgtggtg tggagcgtgg ccgccctcat 1020 ctggccggtg cccatcatcg ccggcttcct gcccaacggc atggaacagc gccggaccac 1080 cgccagcacc accgcagcca cccccgccgc agtgcccgca gggaccaccg cagccgccgc 1140 cgccgccgcc gctgccgccg ccgccgcggc cgtcacttcg ggggtggcga ccaagtgacc 1200 cgctccgctc ctccctgtgt ccgtcctgtg tccgcgcgcg cgggtgcctt tcccgccgga 1260 gactcggccg gtgtgcttcg tgctgtagtt atcgttagtt cctcttcccg agatggggcc 1320 gccgagagac cccagcgcct ttgaaaagca aggtttgtgc tgcgcttcca gttccgaaaa 1380 gcagatgttt aagcccttgg actgagggtg ggatcgcagc tccgaagacg gagaggaggg 1440 aaatggggcc ctttcccctc tattgcatcc ccctgcccga ctccttcccc gcacccacgt 1500 gccctagatt catggcagaa aatgaccaaa tcctgtgtat ttgttttata tatttaataa 1560 ctgttttaaa tgaaagtttt agtaaaaaaa atacaaaaca aaaagattaa attgctattg 1620 ctgtagtaag agaagctctt tgtatctgaa catagttgta tttgaaattt gtggtttttt 1680 aatttattta aaattggggg gagggcatgg gaaggattta acaccgatat attgttaccg 1740 ctgaaaatga actttatgaa ccttttccaa gttgatctat ccagtgacgt ggcctggtgg 1800 gcgtttcttc ttgtacttat gtggtttttt ggcttttaat acagacattt tcctccagaa 1860 aaaaaaaaaa aaaaaa 1876 <210> 273 <211> 1422 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1422) <223> TNFAIP6 mRNA <400> 273 agtcacattt cagccactgc tctgagaatt tgtgagcagc ccctaacagg ctgttacttc 60 actacaactg acgatatgat catcttaatt tacttatttc tcttgctatg ggaagacact 120 caaggatggg gattcaagga tggaattttt cataactcca tatggcttga acgagcagcc 180 ggtgtgtacc acagagaagc acggtctggc aaatacaagc tcacctacgc agaagctaag 240 gcggtgtgtg aatttgaagg cggccatctc gcaacttaca agcagctaga ggcagccaga 300 aaaattggat ttcatgtctg tgctgctgga tggatggcta agggcagagt tggatacccc 360 attgtgaagc cagggcccaa ctgtggattt ggaaaaactg gcattattga ttatggaatc 420 cgtctcaata ggagtgaaag atgggatgcc tattgctaca acccacacgc aaaggagtgt 480 ggtggcgtct ttacagatcc aaagcaaatt tttaaatctc caggcttccc aaatgagtac 540 gaagataacc aaatctgcta ctggcacatt agactcaagt atggtcagcg tattcacctg 600 agttttttag attttgacct tgaagatgac ccaggttgct tggctgatta tgttgaaata 660 tatgacagtt acgatgatgt ccatggcttt gtgggaagat actgtggaga tgagcttcca 720 gatgacatca tcagtacagg aaatgtcatg accttgaagt ttctaagtga tgcttcagtg 780 acagctggag gtttccaaat caaatatgtt gcaatggatc ctgtatccaa atccagtcaa 840 ggaaaaaata caagtactac ttctactgga aataaaaact ttttagctgg aagatttagc 900 cacttataaa aaaaaaaaaa aggatgatca aaacacacag tgtttatgtt ggaatctttt 960 ggaactcctt tgatctcact gttattatta acatttattt attatttttc taaatgtgaa 1020 agcaatacat aatttaggga aaattggaaa atataggaaa ctttaaacga gaaaatgaaa 1080 cctctcataa tcccactgca tagaaataac aagcgttaac attttcatat ttttttcttt 1140 cagtcatttt tctatttgtg gtatatgtat atatgtacct atatgtattt gcatttgaaa 1200 ttttggaatc ctgctctatg tacagttttg tattatactt tttaaatctt gaactttata 1260 aacattttct gaaatcattg attattctac aaaaacatga ttttaaacag ctgtaaaata 1320 ttctatgata tgaatgtttt atgcattatt taagcctgtc tctattgttg gaatttcagg 1380 tcattttcat aaatattgtt gcaataaata tccttgaaca ca 1422 <210> 274 <211> 3677 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3677) <223> VEGFA mRNA <400> 274 tcgcggaggc ttggggcagc cgggtagctc ggaggtcgtg gcgctggggg ctagcaccag 60 cgctctgtcg ggaggcgcag cggttaggtg gaccggtcag cggactcacc ggccagggcg 120 ctcggtgctg gaatttgata ttcattgatc cgggttttat ccctcttctt ttttcttaaa 180 catttttttt taaaactgta ttgtttctcg ttttaattta tttttgcttg ccattcccca 240 cttgaatcgg gccgacggct tggggagatt gctctacttc cccaaatcac tgtggatttt 300 ggaaaccagc agaaagagga aagaggtagc aagagctcca gagagaagtc gaggaagaga 360 gagacggggt cagagagagc gcgcgggcgt gcgagcagcg aaagcgacag gggcaaagtg 420 agtgacctgc ttttgggggt gaccgccgga gcgcggcgtg agccctcccc cttgggatcc 480 cgcagctgac cagtcgcgct gacggacaga cagacagaca ccgcccccag ccccagctac 540 cacctcctcc ccggccggcg gcggacagtg gacgcggcgg cgagccgcgg gcaggggccg 600 gagcccgcgc ccggaggcgg ggtggagggg gtcggggctc gcggcgtcgc actgaaactt 660 ttcgtccaac ttctgggctg ttctcgcttc ggaggagccg tggtccgcgc gggggaagcc 720 gagccgagcg gagccgcgag aagtgctagc tcgggccggg aggagccgca gccggaggag 780 ggggaggagg aagaagagaa ggaagaggag agggggccgc agtggcgact cggcgctcgg 840 aagccgggct catggacggg tgaggcggcg gtgtgcgcag acagtgctcc agccgcgcgc 900 gctccccagg ccctggcccg ggcctcgggc cggggaggaa gagtagctcg ccgaggcgcc 960 gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc 1020 ggtcgggcct ccgaaaccat gaactttctg ctgtcttggg tgcattggag ccttgccttg 1080 ctgctctacc tccaccatgc caagtggtcc caggctgcac ccatggcaga aggaggaggg 1140 cagaatcatc acgaagtggt gaagttcatg gatgtctatc agcgcagcta ctgccatcca 1200 atcgagaccc tggtggacat cttccaggag taccctgatg agatcgagta catcttcaag 1260 ccatcctgtg tgcccctgat gcgatgcggg ggctgctgca atgacgaggg cctggagtgt 1320 gtgcccactg aggagtccaa catcaccatg cagattatgc ggatcaaacc tcaccaaggc 1380 cagcacatag gagagatgag cttcctacag cacaacaaat gtgaatgcag accaaagaaa 1440 gatagagcaa gacaagaaaa aaaatcagtt cgaggaaagg gaaaggggca aaaacgaaag 1500 cgcaagaaat cccggtataa gtcctggagc gtgtacgttg gtgcccgctg ctgtctaatg 1560 ccctggagcc tccctggccc ccatccctgt gggccttgct cagagcggag aaagcatttg 1620 tttgtacaag atccgcagac gtgtaaatgt tcctgcaaaa acacagactc gcgttgcaag 1680 gcgaggcagc ttgagttaaa cgaacgtact tgcagatgtg acaagccgag gcggtgagcc 1740 gggcaggagg aaggagcctc cctcagggtt tcgggaacca gatctctcac caggaaagac 1800 tgatacagaa cgatcgatac agaaaccacg ctgccgccac cacaccatca ccatcgacag 1860 aacagtcctt aatccagaaa cctgaaatga aggaagagga gactctgcgc agagcacttt 1920 gggtccggag ggcgagactc cggcggaagc attcccgggc gggtgaccca gcacggtccc 1980 tcttggaatt ggattcgcca ttttattttt cttgctgcta aatcaccgag cccggaagat 2040 tagagagttt tatttctggg attcctgtag acacacccac ccacatacat acatttatat 2100 atatatatat tatatatata taaaaataaa tatctctatt ttatatatat aaaatatata 2160 tattcttttt ttaaattaac agtgctaatg ttattggtgt cttcactgga tgtatttgac 2220 tgctgtggac ttgagttggg aggggaatgt tcccactcag atcctgacag ggaagaggag 2280 gagatgagag actctggcat gatctttttt ttgtcccact tggtggggcc agggtcctct 2340 cccctgccca ggaatgtgca aggccagggc atgggggcaa atatgaccca gttttgggaa 2400 caccgacaaa cccagccctg gcgctgagcc tctctacccc aggtcagacg gacagaaaga 2460 cagatcacag gtacagggat gaggacaccg gctctgacca ggagtttggg gagcttcagg 2520 acattgctgt gctttgggga ttccctccac atgctgcacg cgcatctcgc ccccaggggc 2580 actgcctgga agattcagga gcctgggcgg ccttcgctta ctctcacctg cttctgagtt 2640 gcccaggaga ccactggcag atgtcccggc gaagagaaga gacacattgt tggaagaagc 2700 agcccatgac agctcccctt cctgggactc gccctcatcc tcttcctgct ccccttcctg 2760 gggtgcagcc taaaaggacc tatgtcctca caccattgaa accactagtt ctgtcccccc 2820 aggagacctg gttgtgtgtg tgtgagtggt tgaccttcct ccatcccctg gtccttccct 2880 tcccttcccg aggcacagag agacagggca ggatccacgt gcccattgtg gaggcagaga 2940 aaagagaaag tgttttatat acggtactta tttaatatcc ctttttaatt agaaattaaa 3000 acagttaatt taattaaaga gtagggtttt ttttcagtat tcttggttaa tatttaattt 3060 caactattta tgagatgtat cttttgctct ctcttgctct cttatttgta ccggtttttg 3120 tatataaaat tcatgtttcc aatctctctc tccctgatcg gtgacagtca ctagcttatc 3180 ttgaacagat atttaatttt gctaacactc agctctgccc tccccgatcc cctggctccc 3240 cagcacacat tcctttgaaa taaggtttca atatacatct acatactata tatatatttg 3300 gcaacttgta tttgtgtgta tatatatata tatatgttta tgtatatatg tgattctgat 3360 aaaatagaca ttgctattct gttttttata tgtaaaaaca aaacaagaaa aaatagagaa 3420 ttctacatac taaatctctc tcctttttta attttaatat ttgttatcat ttatttattg 3480 gtgctactgt ttatccgtaa taattgtggg gaaaagatat taacatcacg tctttgtctc 3540 tagtgcagtt tttcgagata ttccgtagta catatttatt tttaaacaac gacaaagaaa 3600 tacagatata tcttaaaaaa aaaaaagcat tttgtattaa agaatttaat tctgatctca 3660 aaaaaaaaaa aaaaaaa 3677 <210> 275 <211> 6194 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6194) <223> WNT5A mRNA <400> 275 actaactcgc ggctgcagga tcagcgtctg gaagcagacg tttcggctac agacccagag 60 aggaggagct ggagatcagg aggcgtgagc cgccaagagt ttgcagaatc tgtggtgtga 120 atgaactggg ggcacctggg cgcacagatc gccccccttc ccccgccccg ggccacagtt 180 gagtagtggt acattttttt caccctcttg tgaagaattt ctttttatta ttatttgtcg 240 taaggtcttt tgcacaatca cgcccacatt tggggttgga aagccctaat taccgccgtc 300 gctgatggac gttggaaacg gagcgcctct ccgtggaaca gttgcctgcg cgccctcgcc 360 ggaccggcgg ctccctagtt gcgccccgac caggccctgc ccttgctgcc ggctcgcgcg 420 cgtccgcgcc ccctccattc ctgggcgcat cccagctctg ccccaactcg ggagtccagg 480 cccgggcgcc agtgcccgct tcagctccgg ttcactgcgc ccgccggacg cgcgccggag 540 gactccgcag ccctgctcct gaccgtcccc ccaggcttaa cccggtcgct ccgctcggat 600 tcctcggctg cgctcgctcg ggtggcgact tcctccccgc gccccctccc cctcgccatg 660 aagaagtcca ttggaatatt aagcccagga gttgctttgg ggatggctgg aagtgcaatg 720 tcttccaagt tcttcctagt ggctttggcc atatttttct ccttcgccca ggttgtaatt 780 gaagccaatt cttggtggtc gctaggtatg aataaccctg ttcagatgtc agaagtatat 840 attataggag cacagcctct ctgcagccaa ctggcaggac tttctcaagg acagaagaaa 900 ctgtgccact tgtatcagga ccacatgcag tacatcggag aaggcgcgaa gacaggcatc 960 aaagaatgcc agtatcaatt ccgacatcga aggtggaact gcagcactgt ggataacacc 1020 tctgtttttg gcagggtgat gcagataggc agccgcgaga cggccttcac atacgcggtg 1080 agcgcagcag gggtggtgaa cgccatgagc cgggcgtgcc gcgagggcga gctgtccacc 1140 tgcggctgca gccgcgccgc gcgccccaag gacctgccgc gggactggct ctggggcggc 1200 tgcggcgaca acatcgacta tggctaccgc tttgccaagg agttcgtgga cgcccgcgag 1260 cgggagcgca tccacgccaa gggctcctac gagagtgctc gcatcctcat gaacctgcac 1320 aacaacgagg ccggccgcag gacggtgtac aacctggctg atgtggcctg caagtgccat 1380 ggggtgtccg gctcatgtag cctgaagaca tgctggctgc agctggcaga cttccgcaag 1440 gtgggtgatg ccctgaagga gaagtacgac agcgcggcgg ccatgcggct caacagccgg 1500 ggcaagttgg tacaggtcaa cagccgcttc aactcgccca ccacacaaga cctggtctac 1560 atcgacccca gccctgacta ctgcgtgcgc aatgagagca ccggctcgct gggcacgcag 1620 ggccgcctgt gcaacaagac gtcggagggc atggatggct gcgagctcat gtgctgcggc 1680 cgtggctacg accagttcaa gaccgtgcag acggagcgct gccactgcaa gttccactgg 1740 tgctgctacg tcaagtgcaa gaagtgcacg gagatcgtgg accagtttgt gtgcaagtag 1800 tgggtgccac ccagcactca gccccgctcc caggacccgc ttatttatag aaagtacagt 1860 gattctggtt tttggttttt agaaatattt tttatttttc cccaagaatt gcaaccggaa 1920 ccattttttt tcctgttacc atctaagaac tctgtggttt attattaata ttataattat 1980 tatttggcaa taatgggggt gggaaccaag aaaaatattt attttgtgga tctttgaaaa 2040 ggtaatacaa gacttctttt gatagtatag aatgaagggg aaataacaca taccctaact 2100 tagctgtgtg gacatggtac acatccagaa ggtaaagaaa tacattttct ttttctcaaa 2160 tatgccatca tatgggatgg gtaggttcca gttgaaagag ggtggtagaa atctattcac 2220 aattcagctt ctatgaccaa aatgagttgt aaattctctg gtgcaagata aaaggtcttg 2280 ggaaaacaaa acaaaacaaa acaaacctcc cttccccagc agggctgcta gcttgctttc 2340 tgcattttca aaatgataat ttacaatgga aggacaagaa tgtcatattc tcaaggaaaa 2400 aaggtatatc acatgtctca ttctcctcaa atattccatt tgcagacaga ccgtcatatt 2460 ctaatagctc atgaaatttg ggcagcaggg aggaaagtcc ccagaaatta aaaaatttaa 2520 aactcttatg tcaagatgtt gatttgaagc tgttataaga attaggattc cagattgtaa 2580 aaagatcccc aaatgattct ggacactaga tttttttgtt tggggaggtt ggcttgaaca 2640 taaatgaaaa tatcctgtta ttttcttagg gatacttggt tagtaaatta taatagtaaa 2700 aataatacat gaatcccatt cacaggttct cagcccaagc aacaaggtaa ttgcgtgcca 2760 ttcagcactg caccagagca gacaacctat ttgaggaaaa acagtgaaat ccaccttcct 2820 cttcacactg agccctctct gattcctccg tgttgtgatg tgatgctggc cacgtttcca 2880 aacggcagct ccactgggtc ccctttggtt gtaggacagg aaatgaaaca ttaggagctc 2940 tgcttggaaa acagttcact acttagggat ttttgtttcc taaaactttt attttgagga 3000 gcagtagttt tctatgtttt aatgacagaa cttggctaat ggaattcaca gaggtgttgc 3060 agcgtatcac tgttatgatc ctgtgtttag attatccact catgcttctc ctattgtact 3120 gcaggtgtac cttaaaactg ttcccagtgt acttgaacag ttgcatttat aaggggggaa 3180 atgtggttta atggtgcctg atatctcaaa gtcttttgta cataacatat atatatatat 3240 acatatatat aaatataaat ataaatatat ctcattgcag ccagtgattt agatttacag 3300 tttactctgg ggttatttct ctgtctagag cattgttgtc cttcactgca gtccagttgg 3360 gattattcca aaagtttttt gagtcttgag cttgggctgt ggccctgctg tgatcatacc 3420 ttgagcacga cgaagcaacc ttgtttctga ggaagcttga gttctgactc actgaaatgc 3480 gtgttgggtt gaagatatct tttttctttt ctgcctcacc cctttgtctc caacctccat 3540 ttctgttcac tttgtggaga gggcattact tgttcgttat agacatggac gttaagagat 3600 attcaaaact cagaagcatc agcaatgttt ctcttttctt agttcattct gcagaatgga 3660 aacccatgcc tattagaaat gacagtactt attaattgag tccctaagga atattcagcc 3720 cactacatag atagcttttt tttttttttt tttaataagg acacctcttt ccaaacagtg 3780 ccatcaaata tgttcttatc tcagacttac gttgttttaa aagtttggaa agatacacat 3840 ctttcatacc ccccttaggc aggttggctt tcatatcacc tcagccaact gtggctctta 3900 atttattgca taatgatatt cacatcccct cagttgcagt gaattgtgag caaaagatct 3960 tgaaagcaaa aagcactaat tagtttaaaa tgtcactttt ttggttttta ttatacaaaa 4020 accatgaagt acttttttta tttgctaaat cagattgttc ctttttagtg actcatgttt 4080 atgaagagag ttgagtttaa caatcctagc ttttaaaaga aactatttaa tgtaaaatat 4140 tctacatgtc attcagatat tatgtatatc ttctagcctt tattctgtac ttttaatgta 4200 catatttctg tcttgcgtga tttgtatatt tcactggttt aaaaaacaaa catcgaaagg 4260 cttatgccaa atggaagata gaatataaaa taaaacgtta cttgtatatt ggtaagtggt 4320 ttcaattgtc cttcagataa ttcatgtgga gatttttgga gaaaccatga cggatagttt 4380 aggatgacta catgtcaaag taataaaaga gtggtgaatt ttaccaaaac caagctattt 4440 ggaagcttca aaaggtttct atatgtaatg gaacaaaagg ggaattctct tttcctatat 4500 atgttcctta caaaaaaaaa aaaaaaagaa atcaagcaga tggcttaaag ctggttatag 4560 gattgctcac attcttttag cattatgcat gtaacttaat tgttttagag cgtgttgctg 4620 ttgtaacatc ccagagaaga atgaaaaggc acatgctttt atccgtgacc agatttttag 4680 tccaaaaaaa tgtatttttt tgtgtgttta ccactgcaac tattgcacct ctctatttga 4740 atttactgtg gaccatgtgt ggtgtctcta tgccctttga aagcagtttt tataaaaaga 4800 aagcccgggt ctgcagagaa tgaaaactgg ttggaaacta aaggttcatt gtgttaagtg 4860 caattaatac aagttattgt gcttttcaaa aatgtacacg gaaatctgga cagtgctcca 4920 cagattgata cattagcctt tgctttttct ctttccggat aaccttgtaa catattgaaa 4980 ccttttaagg atgccaagaa tgcattattc cacaaaaaaa cagcagacca acatatagag 5040 tgtttaaaat agcatttctg ggcaaattca aactcttgtg gttctaggac tcacatctgt 5100 ttcagttttt cctcagttgt atattgacca gtgttcttta ttgcaaaaac atatacccga 5160 tttagcagtg tcagcgtatt ttttcttctc atcctggagc gtattcaaga tcttcccaat 5220 acaagaaaat taataaaaaa tttatatata ggcagcagca aaagagccat gttcaaaata 5280 gtcattatgg gctcaaatag aaagaagact tttaagtttt aatccagttt atctgttgag 5340 ttctgtgagc tactgacctc ctgagactgg cactgtgtaa gttttagttg cctaccctag 5400 ctcttttctc gtacaatttt gccaatacca agtttcaatt tgtttttaca aaacattatt 5460 caagccacta gaattatcaa atatgacgct atagcagagt aaatactctg aataagagac 5520 cggtactagc taactccaag agatcgttag cagcatcagt ccacaaacac ttagtggccc 5580 acaatatata gagagataga aaaggtagtt ataacttgaa gcatgtattt aatgcaaata 5640 ggcacgaagg cacaggtcta aaatactaca ttgtcactgt aagctatact tttaaaatat 5700 ttattttttt taaagtattt tctagtcttt tctctctctg tggaatggtg aaagagagat 5760 gccgtgtttt gaaagtaaga tgatgaaatg aatttttaat tcaagaaaca ttcagaaaca 5820 taggaattaa aacttagaga aatgatctaa tttccctgtt cacacaaact ttacacttta 5880 atctgatgat tggatatttt attttagtga aacatcatct tgttagctaa ctttaaaaaa 5940 tggatgtaga atgattaaag gttggtatga ttttttttta atgtatcagt ttgaacctag 6000 aatattgaat taaaatgctg tctcagtatt ttaaaagcaa aaaaggaatg gaggaaaatt 6060 gcatcttaga ccatttttat atgcagtgta caatttgctg ggctagaaat gagataaaga 6120 ttatttattt ttgttcatat cttgtacttt tctattaaaa tcattttatg aaatccaaaa 6180 aaaaaaaaaa aaaa 6194 <210> 276 <211> 1309 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1309) <223> GAPDH mRNA <400> 276 gctctctgct cctcctgttc gacagtcagc cgcatcttct tttgcgtcgc cagccgagcc 60 acatcgctca gacaccatgg ggaaggtgaa ggtcggagtc aacggatttg gtcgtattgg 120 gcgcctggtc accagggctg cttttaactc tggtaaagtg gatattgttg ccatcaatga 180 ccccttcatt gacctcaact acatggttta catgttccaa tatgattcca cccatggcaa 240 attccatggc accgtcaagg ctgagaacgg gaagcttgtc atcaatggaa atcccatcac 300 catcttccag gagcgagatc cctccaaaat caagtggggc gatgctggcg ctgagtacgt 360 cgtggagtcc actggcgtct tcaccaccat ggagaaggct ggggctcatt tgcagggggg 420 agccaaaagg gtcatcatct ctgccccctc tgctgatgcc cccatgttcg tcatgggtgt 480 gaaccatgag aagtatgaca acagcctcaa gatcatcagc aatgcctcct gcaccaccaa 540 ctgcttagca cccctggcca aggtcatcca tgacaacttt ggtatcgtgg aaggactcat 600 gaccacagtc catgccatca ctgccaccca gaagactgtg gatggcccct ccgggaaact 660 gtggcgtgat ggccgcgggg ctctccagaa catcatccct gcctctactg gcgctgccaa 720 ggctgtgggc aaggtcatcc ctgagctgaa cgggaagctc actggcatgg ccttccgtgt 780 ccccactgcc aacgtgtcag tggtggacct gacctgccgt ctagaaaaac ctgccaaata 840 tgatgacatc aagaaggtgg tgaagcaggc gtcggagggc cccctcaagg gcatcctggg 900 ctacactgag caccaggtgg tctcctctga cttcaacagc gacacccact cctccacctt 960 tgacgctggg gctggcattg ccctcaacga ccactttgtc aagctcattt cctggtatga 1020 caacgaattt ggctacagca acagggtggt ggacctcatg gcccacatgg cctccaagga 1080 gtaagacccc tggaccacca gccccagcaa gagcacaaga ggaagagaga gaccctcact 1140 gctggggagt ccctgccaca ctcagtcccc caccacactg aatctcccct cctcacagtt 1200 gccatgtaga ccccttgaag aggggagggg cctagggagc cgcaccttgt catgtaccat 1260 caataaagta ccctgtgctc aaccagttaa aaaaaaaaaa aaaaaaaaa 1309 <110> Korea University Industry and Academy Cooperation Foundation <120> Composition for the screening of wound healing agent and screening method for the same <130> MP18-299 <160> 276 <170> KoPatentIn 3.0 <210> 1 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hACTA2 F <400> 1 tagcacccag caccatgaag 20 <210> 2 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hACTA2 R <400> 2 ctgctggaag gtggacagag 20 <210> 3 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hBMPER F <400> 3 aagcatggtg ctgtgtacga 20 <210> 4 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hBMPER R <400> 4 caagtttgct ggacagtggc 20 <210> 5 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCCL2 F <400> 5 atcaatgccc cagtcacctg 20 <210> 6 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCCL2 R <400> 6 tctccttggc cacaatggtc 20 <210> 7 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCH25H F <400> 7 acatctggct ttccgtggag 20 <210> 8 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCH25H R <400> 8 acggagcgaa gttgcagtta 20 <210> 9 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL1A1 F <400> 9 catgaccgag acgtgtggaa 20 <210> 10 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL1A1 R <400> 10 ggcagttctt ggtctcgtca 20 <210> 11 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL1A2 F <400> 11 ctgctggaag tcgtggtgat 20 <210> 12 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL1A2 R <400> 12 acgaagccct tctttcccag 20 <210> 13 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL3A1 F <400> 13 tgttccagga gctaaaggcg 20 <210> 14 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL3A1 R <400> 14 ctcctgggat gccatttggt 20 <210> 15 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL4A1 F <400> 15 ttttgtgatg cacaccagcg 20 <210> 16 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL4A1 R <400> 16 agtaattgca ggtcccacgg 20 <210> 17 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL5A1 F <400> 17 agacatgggc atcaagggtg 20 <210> 18 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL5A1 R <400> 18 ccgagttttc ccttctcccc 20 <210> 19 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL5A2 F <400> 19 gagaacaagg acctccaggc 20 <210> 20 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCOL5A2 R <400> 20 tctaggtcct aacgggccaa 20 <210> 21 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCSF3 F <400> 21 cggccttttc ctctaccagg 20 <210> 22 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCSF3 R <400> 22 ggccattccc agttcttcca 20 <210> 23 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCTGF F <400> 23 gtttggccca gacccaacta 20 <210> 24 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCTGF R <400> 24 ggctctgctt ctctagcctg 20 <210> 25 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCTNNB1 F <400> 25 atgatggtct gccaagtggg 20 <210> 26 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCTNNB1 R <400> 26 ggccatctct gcttcttggt 20 <210> 27 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCTSK F <400> 27 gggggacatg accagtgaag 20 <210> 28 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCTSK R <400> 28 cagagtctgg ggctctacct 20 <210> 29 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCXCL1 F <400> 29 tgcagggaat tcaccccaag 20 <210> 30 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCXCL1 R <400> 30 agctttccgc ccattcttga 20 <210> 31 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCXCL5 F <400> 31 tgtgttgaga gagctgcgtt 20 <210> 32 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCXCL5 R <400> 32 cttccacctt ggagcactgt 20 <210> 33 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCXCL6 F <400> 33 ctgtctctgc tgtgctgaca 20 <210> 34 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hCXCL6 R <400> 34 cacttccacc ttggagcact 20 <210> 35 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hDUSP6 F <400> 35 cggaaatggc gatcagcaag 20 <210> 36 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hDUSP6 R <400> 36 tgtgcgacga ctcgtatagc 20 <210> 37 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hEGFR F <400> 37 ttgccgcaaa gtgtgtaacg 20 <210> 38 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hEGFR R <400> 38 gagatcgcca ctgatggagg 20 <210> 39 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hEGR1 F <400> 39 gctggtggag accagttacc 20 <210> 40 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hEGR1 R <400> 40 ctgaccaagc tgaagagggg 20 <210> 41 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hEMP1 F <400> 41 atgccagtga agatgccctc 20 <210> 42 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hEMP1 R <400> 42 ggtgaagagc tggaacacga 20 <210> 43 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hENO1 F <400> 43 ctgcctcctg ctcaaagtca 20 <210> 44 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hENO1 R <400> 44 aaccaggtca gcgatgaagg 20 <210> 45 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hERRFI1 F <400> 45 gacaggcctc ccaaagtacc 20 <210> 46 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hERRFI1 R <400> 46 acttgggatc aggggcaaag 20 <210> 47 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hESM1 F <400> 47 acttgctacc gcacagtctc 20 <210> 48 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hESM1 R <400> 48 ctgcaatcca tcccgaaggt 20 <210> 49 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGA F <400> 49 ctgcctggtc ctaagtgtgg 20 <210> 50 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGA R <400> 50 gcagaagggc cagtctgaat 20 <210> 51 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGF10 F <400> 51 gtgcggagct acaatcacct 20 <210> 52 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGF10 R <400> 52 acgggcagtt ctccttcttg 20 <210> 53 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGF2 F <400> 53 aaaaacgggg gcttcttcct 20 <210> 54 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGF2 R <400> 54 agccaggtaa cggttagcac 20 <210> 55 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGF7 F <400> 55 tggatcctgc caactttgct 20 <210> 56 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFGF7 R <400> 56 ttcttgtgtg tcgctcaggg 20 <210> 57 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFOSL1 F <400> 57 gcggagactg acaaactgga 20 <210> 58 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFOSL1 R <400> 58 cttggctcct tccgggattt 20 <210> 59 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFST F <400> 59 tgctctgcca gttcatggag 20 <210> 60 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hFST R <400> 60 gcactcctcc ttgctcagtt 20 <210> 61 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHAS2 F <400> 61 tgacaggcat ctcacgaacc 20 <210> 62 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHAS2 R <400> 62 gggtctgctg gtttagccat 20 <210> 63 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHBEGF F <400> 63 agtccgtgac ttgcaagagg 20 <210> 64 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHBEGF R <400> 64 cctcttcttc cctagcccct 20 <210> 65 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHGF F <400> 65 accctggtgt ttcacaagca 20 <210> 66 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHGF R <400> 66 tcccagcgct gacaaatctt 20 <210> 67 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHMGA2 F <400> 67 gccctctcct aagagaccca 20 <210> 68 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hHMGA2 R <400> 68 ctgcctcttg gccgtttttc 20 <210> 69 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hICAM1 F <400> 69 ccaggagaca ctgcagacag 20 <210> 70 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hICAM1 R <400> 70 cttcactgtc acctcggtcc 20 <210> 71 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIER3 F <400> 71 cctgatggct gaagagggtg 20 <210> 72 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIER3 R <400> 72 attaaagggc tcgaggacgg 20 <210> 73 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL-13RA2 F <400> 73 atgctgggaa ggtgaagacc 20 <210> 74 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL-13RA2 R <400> 74 ggcttacgca aaagcagacc 20 <210> 75 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL-33 F <400> 75 tcaggtgacg gtgttgatgg 20 <210> 76 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL-33 R <400> 76 ggagctccac agagtgttcc 20 <210> 77 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL1B F <400> 77 ccacctccag ggacaggata 20 <210> 78 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL1B R <400> 78 aacacgcagg acaggtacag 20 <210> 79 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL6 F <400> 79 agtgaggaac aagccagagc 20 <210> 80 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL6 R <400> 80 atttgtggtt gggtcagggg 20 <210> 81 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL6ST F <400> 81 acacagcagt ggtattgggg 20 <210> 82 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL6ST R <400> 82 actggacagt gctcgaagtg 20 <210> 83 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL7R F <400> 83 ccctagactg cagggagagt 20 <210> 84 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL7R R <400> 84 ggagagaaaa tggagggggc 20 <210> 85 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL8 F <400> 85 ctccaaacct ttccacccca 20 <210> 86 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hIL8 R <400> 86 ttccttgggg tccagacaga 20 <210> 87 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA1 F <400> 87 ggcagcacaa ttcatgcaca 20 <210> 88 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA1 R <400> 88 tgatcatctt ccagcggagc 20 <210> 89 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA2 F <400> 89 cacaaagaca caggtggggt 20 <210> 90 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA2 R <400> 90 tgggatgtct gggatgttgc 20 <210> 91 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA3 F <400> 91 ggacatgtgg cttggagtga 20 <210> 92 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA3 R <400> 92 gctggtcttc tgaccctgac 20 <210> 93 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA4 F <400> 93 tggagcttct gtctgtgctg 20 <210> 94 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA4 R <400> 94 ctcccgagcc agagttgatg 20 <210> 95 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA5 F <400> 95 acatctgtgt gcctgacctg 20 <210> 96 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGA5 R <400> 96 ctcacccaca ttctgggcat 20 <210> 97 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGAV F <400> 97 tccgattcca aactgggagc 20 <210> 98 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGAV R <400> 98 aaggccactg aagatggagc 20 <210> 99 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGB1 F <400> 99 gtcgtgtgtg tgagtgcaac 20 <210> 100 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGB1 R <400> 100 agacaccaca ctcgcagatg 20 <210> 101 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGB3 F <400> 101 gccctgctca tctggaaact 20 <210> 102 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGB3 R <400> 102 ttggtgaagg tagacgtggc 20 <210> 103 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGB5 F <400> 103 cacccaaaat gtgcctggtg 20 <210> 104 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hITGB5 R <400> 104 tcaggacatg gaagctgctg 20 <210> 105 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> hKRTAP1-5 F <400> 105 cagacagtcg tgtggaggg 19 <210> 106 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hKRTAP1-5 R <400> 106 gcaggactgt ccacagtagg 20 <210> 107 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hLPXN F <400> 107 tgactgagat gcaggccaag 20 <210> 108 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hLPXN R <400> 108 aggtcctgca attcctgctc 20 <210> 109 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMAPK1 F <400> 109 acctactgcc agagaaccct 20 <210> 110 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMAPK1 R <400> 110 tcgatggttg gtgctcgaat 20 <210> 111 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMAPK3 F <400> 111 accacattct gggcatcctg 20 <210> 112 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMAPK3 R <400> 112 cttggtcttg gagggcagag 20 <210> 113 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMCL1 F <400> 113 gaggaggagg aggacgagtt 20 <210> 114 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMCL1 R <400> 114 ctgcccattg gctttgtgtc 20 <210> 115 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMIF F <400> 115 cagaaccgct cctacagcaa 20 <210> 116 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMIF R <400> 116 aaggtggagt tgttccagcc 20 <210> 117 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMMP1 F <400> 117 agtggcccag tggttgaaaa 20 <210> 118 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMMP1 R <400> 118 ccacatcagg cactccacat 20 <210> 119 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMMP2 F <400> 119 ccctgtgtct tccccttcac 20 <210> 120 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMMP2 R <400> 120 atcgtagttg gctgtggtcg 20 <210> 121 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMMP3 F <400> 121 cacagacctg actcggttcc 20 <210> 122 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hMMP3 R <400> 122 aggttctgga gggacaggtt 20 <210> 123 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hVISFATIN F <400> 123 tcggttctgg tggaggtttg 20 <210> 124 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hVISFATIN R <400> 124 ttgggatcag caactgggtc 20 <210> 125 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hNPAS2 F <400> 125 atcctgcagg ccaatatccg 20 <210> 126 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hNPAS2 R <400> 126 ctgctgcagg aacatctgga 20 <210> 127 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPDGFA F <400> 127 ggccaaggtg gaatacgtca 20 <210> 128 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPDGFA R <400> 128 atccggattc aggcttgtgg 20 <210> 129 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLAT F <400> 129 tacagccagc ctcagtttcg 20 <210> 130 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLAT R <400> 130 gagctgatga gtatgccccc 20 <210> 131 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLAU F <400> 131 ccaaaatgct gtgtgctgct 20 <210> 132 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLAU R <400> 132 ttgtccttca gggcacatcc 20 <210> 133 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLAUR F <400> 133 ggcttgaaga tcaccagcct 20 <210> 134 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLAUR R <400> 134 tgcattcgag gtaacggctt 20 <210> 135 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLG F <400> 135 ctacccaaat gctggcctga 20 <210> 136 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPLG R <400> 136 actcgcttct gttcctgagc 20 <210> 137 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPTEN F <400> 137 tgtggtctgc cagctaaagg 20 <210> 138 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPTEN R <400> 138 acacacaggt aacggctgag 20 <210> 139 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPTGS2 F <400> 139 gttccacccg cagtacagaa 20 <210> 140 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPTGS2 R <400> 140 agggcttcag cataaagcgt 20 <210> 141 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPTX3 <400> 141 cctgcatttg ggtcaaagcc 20 <210> 142 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hPTX3 R <400> 142 ctccacccac cacaaacact 20 <210> 143 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hRAC1 F <400> 143 catcacctat ccgcagggtc 20 <210> 144 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hRAC1 R <400> 144 tcggatcgct tcgtcaaaca 20 <210> 145 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hRHOA F <400> 145 ggtgatggag cctgtggaaa 20 <210> 146 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hRHOA R <400> 146 tgtgtcccac aaagccaact 20 <210> 147 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSERPINB2 F <400> 147 gctggcacag gaggtgttat 20 <210> 148 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSERPINB2 R <400> 148 agggtgagga aaatctgccg 20 <210> 149 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSERPINE 1 F <400> 149 gggccatgga acaaggatga 20 <210> 150 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSERPINE 1 R <400> 150 ccggaacagc ctgaagaagt 20 <210> 151 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSERPINE2 F <400> 151 aagaaacgca ctttcgtggc 20 <210> 152 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSERPINE2 R <400> 152 ccgtggtagg gcagttcaat 20 <210> 153 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSLC20A1 F <400> 153 gcaactcgtg gcttcgtttt 20 <210> 154 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSLC20A1 R <400> 154 gaccacttga caccctcctg 20 <210> 155 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSLIT2 F <400> 155 aagcttcaga ccatcgccaa 20 <210> 156 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSLIT2 R <400> 156 agccacttga gatggcagtc 20 <210> 157 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSMURF2 F <400> 157 agatcctcgg ctgtctgcta 20 <210> 158 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSMURF2 R <400> 158 ctgaaccagg tctcgcttgt 20 <210> 159 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSTAT3 F <400> 159 ctgtgggaag aatcacgcct 20 <210> 160 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSTAT3 R <400> 160 acatcctgaa ggtgctgctc 20 <210> 161 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSTC1 F <400> 161 ttgctgaggt gcaggaagag 20 <210> 162 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSTC1 R <400> 162 caggcttcgg acaagtctgt 20 <210> 163 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSDC4 F <400> 163 ccctccactt ggaaggacac 20 <210> 164 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hSDC4 R <400> 164 caggactaca gcctctccct 20 <210> 165 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTAGLN F <400> 165 aggtctggct gaagaatggc 20 <210> 166 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTAGLN R <400> 166 cacctgctcc atctgcttga 20 <210> 167 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTFPI2 F <400> 167 ctgtctcctg cccctagact 20 <210> 168 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTFPI2 R <400> 168 aaattgttgg cgttgccctc 20 <210> 169 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTGFB1 F <400> 169 tggtggaaac ccacaacgaa 20 <210> 170 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTGFB1 R <400> 170 gagcaacacg ggttcaggta 20 <210> 171 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTGFBR3 F <400> 171 cctcagtcca catccaccac 20 <210> 172 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTGFBR3 R <400> 172 ccacagaacc ctcagacacc 20 <210> 173 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTIMP1 F <400> 173 ggggcttcac caagacctac 20 <210> 174 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTIMP1 R <400> 174 ggaagccctt ttcagagcct 20 <210> 175 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTMEM158 F <400> 175 ctgctgccta gacttcagcc 20 <210> 176 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTMEM158 R <400> 176 ctccacacca cgatgaccag 20 <210> 177 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTNFAIP6 F <400> 177 agcacggtct ggcaaataca 20 <210> 178 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hTNFAIP6 R <400> 178 atccatccag cagcacagac 20 <210> 179 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hVEGFA F <400> 179 cttgccttgc tgctctacct 20 <210> 180 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hVEGFA R <400> 180 gcagtagctg cgctgataga 20 <210> 181 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hWNT5A F <400> 181 cgcgaagaca ggcatcaaag 20 <210> 182 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hWNT5A R <400> 182 atctgcatca ccctgccaaa 20 <210> 183 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hGAPDH F <400> 183 tcctgcacca ccaactgttt 20 <210> 184 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> hGAPDH R <400> 184 gtccactgtc ttctgggtgg 20 <210> 185 <211> 1805 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1805) <223> mRNA ACTA2 <400> 185 gcaggctctc tccccgcccc cgcggggcgg cgcgcactca cccacccgcg ccggagcgga 60 cctttggctt ggcttgtcag ggcttgtcca ggagttccgc tcctctctcc aaccggggtc 120 cccctccagc gaccctaaag cttcccagac ttccgcttca attcctgtcc gcaccccacg 180 cccacctcaa cgtggagcgc agtggtctcc gaggagcgcc ggagctgccc cgcctgccca 240 gcggggtcag cacttcgcat caaggcccaa gaaaagcaag tcctccagcg ttctgagcac 300 ccgggcctga gggaaggtcc taacagcccc cgggagccag tctccaacgc ctcccgcagc 360 agcccgccgc tcccaggtgc ccgcgtgcgc cgctgccgcc gcaatcccgc acgcgtcccg 420 cgcccgcccc actttgccta tccccgggac taagacggga atcctgtgaa gcagctccag 480 ctatgtgtga agaagaggac agcactgcct tggtgtgtga caatggctct gggctctgta 540 aggccggctt tgctggggac gatgctccca gggctgtttt cccatccatt gtgggacgtc 600 ccagacatca gggggtgatg gtgggaatgg gacaaaaaga cagctacgtg ggtgacgaag 660 cacagagcaa aagaggaatc ctgaccctga agtacccgat agaacatggc atcatcacca 720 actgggacga catggaaaag atctggcacc actctttcta caatgagctt cgtgttgccc 780 ctgaagagca tcccaccctg ctcacggagg cacccctgaa ccccaaggcc aaccgggaga 840 aaatgactca aattatgttt gagactttca atgtcccagc catgtatgtg gctatccagg 900 cggtgctgtc tctctatgcc tctggacgca caactggcat cgtgctggac tctggagatg 960 gtgtcaccca caatgtcccc atctatgagg gctatgcctt gccccatgcc atcatgcgtc 1020 tggatctggc tggccgagat ctcactgact acctcatgaa gatcctgact gagcgtggct 1080 attccttcgt tactactgct gagcgtgaga ttgtccggga catcaaggag aaactgtgtt 1140 atgtagctct ggactttgaa aatgagatgg ccactgccgc atcctcatcc tcccttgaga 1200 agagttacga gttgcctgat gggcaagtga tcaccatcgg aaatgaacgt ttccgctgcc 1260 cagagaccct gttccagcca tccttcatcg ggatggagtc tgctggcatc catgaaacca 1320 cctacaacag catcatgaag tgtgatattg acatcaggaa ggacctctat gctaacaatg 1380 tcctatcagg gggcaccact atgtaccctg gcattgccga ccgaatgcag aaggagatca 1440 cggccctagc acccagcacc atgaagatca agatcattgc ccctccggag cgcaaatact 1500 ctgtctggat cggtggctcc atcctggcct ctctgtccac cttccagcag atgtggatca 1560 gcaaacagga atacgatgaa gccgggcctt ccattgtcca ccgcaaatgc ttctaaaaca 1620 ctttcctgct cctctctgtc tctagcacac aactgtgaat gtcctgtgga attatgcctt 1680 cagttctttt ccaaatcatt cctagccaaa gctctgactc gttacctatg tgttttttaa 1740 taaatctgaa ataggctact ggtaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1800 aaaaa 1805 <210> 186 <211> 5582 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(5582) <223> BAPER mRNA <400> 186 agtggagacg cgccttctcg gctctggtcc gcgccctggg gccctggcct ccctggaggg 60 gctggggaac tggaagctgg gccgagagag ttcccgctgc agctatcgcg cagtccctcc 120 tgcgcccggg cgcccccagc gggttccggg aggcgcccgg tgagcccacg tctgttgcgg 180 cggagcgagc gcgctccggg agggccgaga gccggcgggg ctggcaggag ctctcgggcg 240 cccgcctccc tccttcgcgg acggtctccc gacacgccgg ctgagagccc ttttcgactg 300 tgagctgcgg cagctgagca gaggcggcgg cgcgggacct gcagtcgcca gggattccct 360 ccaggtgacg atgctctggt tctccggcgt cggggctctg gctgagcgtt actgccgccg 420 ctcgcctggg attacgtgct gcgtcttgct gctactcaat tgctcggggg tccccatgtc 480 tctggcttcc tccttcttga caggttctgt tgcaaaatgt gaaaatgaag gtgaagtcct 540 ccagattcca tttatcacag acaacccttg cataatgtgt gtctgcttga acaaggaagt 600 gacatgtaag agagagaagt gccccgtgct gtcccgagac tgtgccctgg ccatcaagca 660 gaggggagcc tgttgtgaac agtgcaaagg ttgcacctat gaaggaaata cctataacag 720 ctccttcaaa tggcagagcc cggctgagcc ttgtgttcta cgccagtgcc aggagggcgt 780 tgtcacagag tctggggtgc gctgtgttgt tcattgtaaa aaccctttgg agcatctggg 840 aatgtgctgc cccacatgtc caggctgtgt gtttgagggt gtgcagtatc aagaagggga 900 ggaatttcag ccagaaggaa gcaaatgtac caagtgttcc tgcactggag gcaggacaca 960 atgtgtgaga gaagtctgtc ccattctctc ctgtccccag caccttagtc acataccccc 1020 aggacagtgc tgccccaaat gtttgggtca gaggaaagtg tttgacctcc cttttgggag 1080 ctgcctcttt cgaagtgatg tttatgacaa tggatcctca tttctgtacg ataactgcac 1140 agcttgtacc tgcagggact ctactgtggt ttgcaagagg aagtgctccc accctggtgg 1200 ctgtgaccaa ggccaggagg gctgttgtga agagtgcctc ctacgagtgc ccccagaaga 1260 catcaaagta tgcaaatttg gcaacaagat tttccaggat ggagagatgt ggtcctctat 1320 caattgtacc atctgtgctt gtgtgaaagg caggacggag tgtcgcaata agcagtgcat 1380 tcccatcagt agctgcccac agggcaaaat tctcaacaga aaaggatgct gtcctatttg 1440 cactgaaaag cccggcgttt gcacggtgtt tggagatccc cactacaaca cttttgacgg 1500 tcggacattt aactttcagg ggacgtgtca gtacgttttg acaaaagact gctcctcccc 1560 tgcctcgccc ttccaggtgc tggtgaagaa cgacgcccgc cggacacgct ccttctcgtg 1620 gaccaagtcg gtggagctgg tgctgggcga gagcagggtc agcctgcagc agcacctcac 1680 cgtgcgctgg aacggctcgc gcatcgcgct cccctgccgc gcgccacact tccacatcga 1740 cctggatggc tacctcttga aagtgaccac caaagcaggt ttggaaatat cttgggatgg 1800 agacagtttt gtagaagtca tggctgcgcc gcatctcaag ggcaagctct gtggtctttg 1860 tggcaactac aatggacata aacgtgatga cttaattggt ggagatggaa acttcaagtt 1920 tgatgtggat gactttgctg aatcttggag ggtggagtcc aatgagttct gcaacagacc 1980 tcagagaaag ccagtgcctg aactgtgtca agggacagtc aaggtaaagc tccgggccca 2040 tcgagaatgc caaaagctca aatcctggga gtttcagacc tgccactcga ctgtggacta 2100 cgccactttc taccggtcct gtgtgacaga catgtgtgaa tgtccagtcc ataaaaactg 2160 ttattgcgag tcatttttgg catatacccg ggcctgccag agagagggca tcaaagtcca 2220 ctgggagcct cagcagaatt gtgcagccac ccagtgtaag catggtgctg tgtacgatac 2280 ctgtggtccg ggatgtatca agacgtgtga caactggaat gaaattggtc catgcaacaa 2340 gccgtgcgtt gctgggtgcc actgtccagc aaacttggtc cttcacaagg gaaggtgcat 2400 caagccagtc ctttgtcccc agcggtgacc tttgtttcga tccttaagac tctgaaatct 2460 ggtgactttg acactgaagc ggaagagcca atgaaggact gcagtatttg tgtgcccgat 2520 tctgtaaaca cacacacaca gagtatatat gtgtatatat atatagatat attcaaaaac 2580 attgcatcat ttatatgaac tataggggga ttattatatg tatatttttt gctataagac 2640 atgtattgtt tctaggatcc taacctgtaa gccattgaac atgttgtata aatacaccag 2700 gtgtttttaa tttaataagg tggcatgcag atacattgga tagtgttaac atcacataca 2760 tttgtcattt ttaaggaagt tttctaagag ccctcaattg cctgcctgta ttaattttag 2820 ttttgagtca ggatttgtaa tggagtggga aatgtgtttc tctggagaag ggcacattta 2880 tctaggggca tttcaggttt ccaaagaaag gaatgtatgc ctgggaaaga cagcaggaga 2940 ttggtgaccg gccctaatgg tgcatgaaaa gcgagtgata ggctgttaga atgtattagg 3000 tcatgggcta acattatttc caaaattgat tggctggttg ccaagaaata tatatttgtc 3060 actagggcat aaccgaagaa tcaagtgatt tcttgccatc cttgcgtagt cctcaagtct 3120 tctaatcatc tatgtgtgta tgatggatgt gaccatttat atgtcatgtg ttgaaattaa 3180 agggtgtctg gatgccatgt taattttatt gagcatgaga aagtatttga agaaactgtt 3240 gcacaacata tgatgaaatt ttgatttctc tgaatctcag agtaatttaa gatgggcaaa 3300 tccaatgagt tgatgtaacc catctacatt ttgtggctat ttcatgtata aaatgaaagg 3360 ctttagttat ttctagagga gtcccatcca acactatttg gcgactgtta atatgttata 3420 attattagac agtggaaaag cctttattga ctaattgatt taacctcagt ccaaagaaca 3480 gtctctatac ttgccctcat ttactgatag gctgctacta gttaccattt gattgtcttg 3540 actttcgtct tcagttgaat tggtgaaaac atcaacaaaa acaaaaccca ctgtgtctta 3600 aaataaaatg ttctgcattg tagtcaataa agggcttaag atgtaaaaca atgcattttc 3660 tctctcaaga tgtcctgtgt tatactttac aattagttgt atcaacttca gattcattaa 3720 attttaacag ctgtatttag ttataatttt tgtatcttac aacagtatat ataaagacta 3780 ttattaatag acaaaagcaa acccacgttt ttgacaagcc agcatattgc caatgctcgt 3840 caaagacatt tatgtttctt ttacattcat gacagctaaa gtattaactt ggaatttttt 3900 tttttttttt tgactggaaa atccctagtt gtttgaatta actgaataaa gtgcagggcg 3960 taatagtgac tggctggggg cactgggcct ttgtgttttt tttcattcct gtgtttggat 4020 actaatcacc ctcgtatctg cagcctgagg tagtcaggtc attgtttcaa tgctgccctt 4080 ggaaagaaga ctttgactta ggtgctttgg gatctaagtg tggtttgtga ctatccccat 4140 tatttaagca tttgggggtc tcacttttgc ttatctgtaa cacaaagagg ccatgtagta 4200 tagtgagcag ggttgagaat cgggaaaact agacccctgc cactaacagg ctaggagact 4260 ttgggcagta atgggaggca ctgagggttt gcaaatactt tcctacttgt aatctcattg 4320 attccctgct ctgccctgac aggaggggta gggaaaatca gttgacgttg cctggtggtt 4380 cctaccttct gtaaaacgaa cagattcctt aagattagct ttaaatccct tttcagttca 4440 ctgttggttc tcatctttga aagagggcag cataagggaa atgatggaga agggagaatt 4500 gtggatggtt atttatagct catgattcat ccaaggactg agttattctc cccatgaggc 4560 taaccggcct ctttcccaac acttaatcat ggcagccagg atgggtgaat gatgaaagct 4620 cttctgcatg agccggtttc atcatcttgg gtgggttgat tacaagtttg tgtggcattc 4680 ctttagctgg ggattagctt aatctctgta catttttctc atttctaatt gaagaagaaa 4740 gggagggcag agaggacaga aaattacttg ggtttactaa ttcaaagagc catctctgat 4800 gggagagggt gaggaaatca gctgaatggt tggcctgcat attctttttt aggccacagg 4860 ctacagctga gcaatggctt agtctaatga ttgggcacaa tgaggattta ccaagtgctt 4920 caatgagagc agtcctgttt cattcacatg ggatgttttc aattggttct tcaactaagc 4980 tcttgcagag tgagatgact tgaaataaaa atgttctatg aatattgaat ttgatgagaa 5040 acaagcaccc tcaatgaaga acaagcataa ttatgattct aattgcccat tgttggtact 5100 cagtaaaact aagttctttc ttctctccct ctgtaaatag gaatatttga gggtcctgac 5160 ctaaaatttt ttagctggga agaaaagata tctctttggc atcgacaaga gcaatttttg 5220 ttaaaactgt ggtacactaa gaatcactaa ctcttcaggt tgaaggcctc actcatctta 5280 actcgttgac tgcttcctga ccatcagacc gtcctgtaag agggcatctt tcaataagaa 5340 cgagaaagac ccaggaggtt gactagcttc tcccagcttt cactgaaaca cggataaacc 5400 atttcaactg gaaaactctt cctttttatg agatatttca gacacacaaa aaggcataga 5460 gaaaaatgtt gcaaacatcc atgactacat taccctaatt aagaaacata acctggtaag 5520 tagtcaataa atttttcttg aatcaataaa taaaacctaa taaatgctgt ctcatggttg 5580 ca 5582 <210> 187 <211> 741 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(741) <223> CCL2 mRNA <400> 187 gagaggctga gactaaccca gaaacatcca attctcaaac tgaagctcgc actctcgcct 60 ccagcatgaa agtctctgcc gcccttctgt gcctgctgct catagcagcc accttcattc 120 cccaagggct cgctcagcca gatgcaatca atgccccagt cacctgctgt tataacttca 180 ccaataggaa gatctcagtg cagaggctcg cgagctatag aagaatcacc agcagcaagt 240 gtcccaaaga agctgtgatc ttcaagacca ttgtggccaa ggagatctgt gctgacccca 300 agcagaagtg ggttcaggat tccatggacc acctggacaa gcaaacccaa actccgaaga 360 cttgaacact cactccacaa cccaagaatc tgcagctaac ttattttccc ctagctttcc 420 ccagacaccc tgttttattt tattataatg aattttgttt gttgatgtga aacattatgc 480 cttaagtaat gttaattctt atttaagtta ttgatgtttt aagtttatct ttcatggtac 540 tagtgttttt tagatacaga gacttgggga aattgctttt cctcttgaac cacagttcta 600 cccctgggat gttttgaggg tctttgcaag aatcattaat acaaagaatt ttttttaaca 660 ttccaatgca ttgctaaaat attattgtgg aaatgaatat tttgtaacta ttacaccaaa 720 taaatatatt tttgtacaaa a 741 <210> 188 <211> 1378 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1378) <223> CH25H mRNA <400> 188 agctgccttg cacagcctcg caatgagctg ccacaactgc tccgaccccc aggtcctttg 60 cagctccggg cagctgttcc tgcagcccct ctgggaccac ctgaggagct gggaggccct 120 cctacagtcg cccttcttcc cggtcatctt ctccatcacc acatacgtgg gcttttgcct 180 gcccttcgtg gtcctggata tcctgtgctc ctgggtgccc gccctgcggc gctacaagat 240 ccaccctgac ttctcgccat ccgcgcagca gctgctacct tgcctggggc agaccctcta 300 ccagcatgtg atgtttgtgt tccccgtgac gctgctgcat tgggcccgca gcccggccct 360 cctgccccac gaagctcccg agctgctcct gctgctgcac cacatcctgt tctgcctgct 420 actcttcgac atggagttct tcgtgtggca cctgctgcac cacaaggtgc cctggctgta 480 ccgcaccttc cacaaggtgc accaccagaa ctcgtcctcg ttcgcgctgg caacgcagta 540 tatgagcgtc tgggaactgt tttctttggg cttcttcgac atgatgaacg tcacactgct 600 cgggtgccac ccgctcacca ccctgacctt ccacgtggtc aacatctggc tttccgtgga 660 ggaccactcc ggctacaact tcccttggtc cactcacaga ctggtgccct tcgggtggta 720 cgggggtgtg gtgcaccacg acctgcatca ctctcacttt aactgcaact tcgctccgta 780 ctttacacac tgggacaaaa tactgggaac gctgcggact gcatctgtcc cagcgcggtg 840 atgtggctgc ggtgggtgcc cctaagactc gggactgctg tgcctttcac acttgaatga 900 agagaaacac ctgagctata tattttttta aagcaactaa cttattgctt tatgtttatc 960 tatgaaaacc atagataaaa tctgatgcat ttttgtaatc tgacaaagta atttacatac 1020 tgtttgtgta tcaatacaat tttgtgttct tggtattctt agtctagctc acctcaatag 1080 ccttgaatcc tgcatatgaa ttagacattc atcactggca tatttagaat atctctaaaa 1140 ggacttgttt gtagaataag gaattttcta tgtttcaaag tgttctaaaa cctggctaaa 1200 agaatgtatt tttgtggatg gtgttgactt ctgactctaa aagcaatcaa acatgtttct 1260 gctggacagt gaccaagaat tatagtacct tcttatattt ttttatagaa ctgtatattt 1320 attttgaaag aaatgttatt cgtgctttaa aaaggaaaaa aaaccatgaa tcaaataa 1378 <210> 189 <211> 5927 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(5927) <223> COL1A1 mRNA <400> 189 tcgtcggagc agacgggagt ttctcctcgg ggtcggagca ggaggcacgc ggagtgtgag 60 gccacgcatg agcggacgct aaccccctcc ccagccacaa agagtctaca tgtctagggt 120 ctagacatgt tcagctttgt ggacctccgg ctcctgctcc tcttagcggc caccgccctc 180 ctgacgcacg gccaagagga aggccaagtc gagggccaag acgaagacat cccaccaatc 240 acctgcgtac agaacggcct caggtaccat gaccgagacg tgtggaaacc cgagccctgc 300 cggatctgcg tctgcgacaa cggcaaggtg ttgtgcgatg acgtgatctg tgacgagacc 360 aagaactgcc ccggcgccga agtccccgag ggcgagtgct gtcccgtctg ccccgacggc 420 tcagagtcac ccaccgacca agaaaccacc ggcgtcgagg gacccaaggg agacactggc 480 ccccgaggcc caaggggacc cgcaggcccc cctggccgag atggcatccc tggacagcct 540 ggacttcccg gaccccccgg accccccgga cctcccggac cccctggcct cggaggaaac 600 tttgctcccc agctgtctta tggctatgat gagaaatcaa ccggaggaat ttccgtgcct 660 ggccccatgg gtccctctgg tcctcgtggt ctccctggcc cccctggtgc acctggtccc 720 caaggcttcc aaggtccccc tggtgagcct ggcgagcctg gagcttcagg tcccatgggt 780 ccccgaggtc ccccaggtcc ccctggaaag aatggagatg atggggaagc tggaaaacct 840 ggtcgtcctg gtgagcgtgg gcctcctggg cctcagggtg ctcgaggatt gcccggaaca 900 gctggcctcc ctggaatgaa gggacacaga ggtttcagtg gtttggatgg tgccaaggga 960 gatgctggtc ctgctggtcc taagggtgag cctggcagcc ctggtgaaaa tggagctcct 1020 ggtcagatgg gcccccgtgg cctgcctggt gagagaggtc gccctggagc ccctggccct 1080 gctggtgctc gtggaaatga tggtgctact ggtgctgccg ggccccctgg tcccaccggc 1140 cccgctggtc ctcctggctt ccctggtgct gttggtgcta agggtgaagc tggtccccaa 1200 gggccccgag gctctgaagg tccccagggt gtgcgtggtg agcctggccc ccctggccct 1260 gctggtgctg ctggccctgc tggaaaccct ggtgctgatg gacagcctgg tgctaaaggt 1320 gccaatggtg ctcctggtat tgctggtgct cctggcttcc ctggtgcccg aggcccctct 1380 ggaccccagg gccccggcgg ccctcctggt cccaagggta acagcggtga acctggtgct 1440 cctggcagca aaggagacac tggtgctaag ggagagcctg gccctgttgg tgttcaagga 1500 ccccctggcc ctgctggaga ggaaggaaag cgaggagctc gaggtgaacc cggacccact 1560 ggcctgcccg gaccccctgg cgagcgtggt ggacctggta gccgtggttt ccctggcgca 1620 gatggtgttg ctggtcccaa gggtcccgct ggtgaacgtg gttctcctgg ccctgctggc 1680 cccaaaggat ctcctggtga agctggtcgt cccggtgaag ctggtctgcc tggtgccaag 1740 ggtctgactg gaagccctgg cagccctggt cctgatggca aaactggccc ccctggtccc 1800 gccggtcaag atggtcgccc cggaccccca ggcccacctg gtgcccgtgg tcaggctggt 1860 gtgatgggat tccctggacc taaaggtgct gctggagagc ccggcaaggc tggagagcga 1920 ggtgttcccg gaccccctgg cgctgtcggt cctgctggca aagatggaga ggctggagct 1980 cagggacccc ctggccctgc tggtcccgct ggcgagagag gtgaacaagg ccctgctggc 2040 tcccccggat tccagggtct ccctggtcct gctggtcctc caggtgaagc aggcaaacct 2100 ggtgaacagg gtgttcctgg agaccttggc gcccctggcc cctctggagc aagaggcgag 2160 agaggtttcc ctggcgagcg tggtgtgcaa ggtccccctg gtcctgctgg tccccgaggg 2220 gccaacggtg ctcccggcaa cgatggtgct aagggtgatg ctggtgcccc tggagctccc 2280 ggtagccagg gcgcccctgg ccttcaggga atgcctggtg aacgtggtgc agctggtctt 2340 ccagggccta agggtgacag aggtgatgct ggtcccaaag gtgctgatgg ctctcctggc 2400 aaagatggcg tccgtggtct gactggcccc attggtcctc ctggccctgc tggtgcccct 2460 ggtgacaagg gtgaaagtgg tcccagcggc cctgctggtc ccactggagc tcgtggtgcc 2520 cccggagacc gtggtgagcc tggtcccccc ggccctgctg gctttgctgg cccccctggt 2580 gctgacggcc aacctggtgc taaaggcgaa cctggtgatg ctggtgctaa aggcgatgct 2640 ggtccccctg gccctgccgg acccgctgga ccccctggcc ccattggtaa tgttggtgct 2700 cctggagcca aaggtgctcg cggcagcgct ggtccccctg gtgctactgg tttccctggt 2760 gctgctggcc gagtcggtcc tcctggcccc tctggaaatg ctggaccccc tggccctcct 2820 ggtcctgctg gcaaagaagg cggcaaaggt ccccgtggtg agactggccc tgctggacgt 2880 cctggtgaag ttggtccccc tggtccccct ggccctgctg gcgagaaagg atcccctggt 2940 gctgatggtc ctgctggtgc tcctggtact cccgggcctc aaggtattgc tggacagcgt 3000 ggtgtggtcg gcctgcctgg tcagagagga gagagaggct tccctggtct tcctggcccc 3060 tctggtgaac ctggcaaaca aggtccctct ggagcaagtg gtgaacgtgg tccccctggt 3120 cccatgggcc cccctggatt ggctggaccc cctggtgaat ctggacgtga gggggctcct 3180 ggtgccgaag gttcccctgg acgagacggt tctcctggcg ccaagggtga ccgtggtgag 3240 accggccccg ctggaccccc tggtgctcct ggtgctcctg gtgcccctgg ccccgttggc 3300 cctgctggca agagtggtga tcgtggtgag actggtcctg ctggtcccgc cggtcctgtc 3360 ggccctgttg gcgcccgtgg ccccgccgga ccccaaggcc cccgtggtga caagggtgag 3420 acaggcgaac agggcgacag aggcataaag ggtcaccgtg gcttctctgg cctccagggt 3480 ccccctggcc ctcctggctc tcctggtgaa caaggtccct ctggagcctc tggtcctgct 3540 ggtccccgag gtccccctgg ctctgctggt gctcctggca aagatggact caacggtctc 3600 cctggcccca ttgggccccc tggtcctcgc ggtcgcactg gtgatgctgg tcctgttggt 3660 ccccccggcc ctcctggacc tcctggtccc cctggtcctc ccagcgctgg tttcgacttc 3720 agcttcctgc cccagccacc tcaagagaag gctcacgatg gtggccgcta ctaccgggct 3780 gatgatgcca atgtggttcg tgaccgtgac ctcgaggtgg acaccaccct caagagcctg 3840 agccagcaga tcgagaacat ccggagccca gagggcagcc gcaagaaccc cgcccgcacc 3900 tgccgtgacc tcaagatgtg ccactctgac tggaagagtg gagagtactg gattgacccc 3960 aaccaaggct gcaacctgga tgccatcaaa gtcttctgca acatggagac tggtgagacc 4020 tgcgtgtacc ccactcagcc cagtgtggcc cagaagaact ggtacatcag caagaacccc 4080 aaggacaaga ggcatgtctg gttcggcgag agcatgaccg atggattcca gttcgagtat 4140 ggcggccagg gctccgaccc tgccgatgtg gccatccagc tgaccttcct gcgcctgatg 4200 tccaccgagg cctcccagaa catcacctac cactgcaaga acagcgtggc ctacatggac 4260 cagcagactg gcaacctcaa gaaggccctg ctcctccagg gctccaacga gatcgagatc 4320 cgcgccgagg gcaacagccg cttcacctac agcgtcactg tcgatggctg cacgagtcac 4380 accggagcct ggggcaagac agtgattgaa tacaaaacca ccaagacctc ccgcctgccc 4440 atcatcgatg tggccccctt ggacgttggt gccccagacc aggaattcgg cttcgacgtt 4500 ggccctgtct gcttcctgta aactccctcc atcccaacct ggctccctcc cacccaacca 4560 actttccccc caacccggaa acagacaagc aacccaaact gaaccccctc aaaagccaaa 4620 aaatgggaga caatttcaca tggactttgg aaaatatttt tttcctttgc attcatctct 4680 caaacttagt ttttatcttt gaccaaccga acatgaccaa aaaccaaaag tgcattcaac 4740 cttaccaaaa aaaaaaaaaa aaaaagaata aataaataac tttttaaaaa aggaagcttg 4800 gtccacttgc ttgaagaccc atgcgggggt aagtcccttt ctgcccgttg ggcttatgaa 4860 accccaatgc tgccctttct gctcctttct ccacaccccc cttggggcct cccctccact 4920 ccttcccaaa tctgtctccc cagaagacac aggaaacaat gtattgtctg cccagcaatc 4980 aaaggcaatg ctcaaacacc caagtggccc ccaccctcag cccgctcctg cccgcccagc 5040 acccccaggc cctgggggac ctggggttct cagactgcca aagaagcctt gccatctggc 5100 gctcccatgg ctcttgcaac atctcccctt cgtttttgag ggggtcatgc cgggggagcc 5160 accagcccct cactgggttc ggaggagagt caggaagggc cacgacaaag cagaaacatc 5220 ggatttgggg aacgcgtgtc aatcccttgt gccgcagggc tgggcgggag agactgttct 5280 gttccttgtg taactgtgtt gctgaaagac tacctcgttc ttgtcttgat gtgtcaccgg 5340 ggcaactgcc tgggggcggg gatgggggca gggtggaagc ggctccccat tttataccaa 5400 aggtgctaca tctatgtgat gggtggggtg gggagggaat cactggtgct atagaaattg 5460 agatgccccc ccaggccagc aaatgttcct ttttgttcaa agtctatttt tattccttga 5520 tatttttctt tttttttttt tttttttgtg gatggggact tgtgaatttt tctaaaggtg 5580 ctatttaaca tgggaggaga gcgtgtgcgg ctccagccca gcccgctgct cactttccac 5640 cctctctcca cctgcctctg gcttctcagg cctctgctct ccgacctctc tcctctgaaa 5700 ccctcctcca cagctgcagc ccatcctccc ggctccctcc tagtctgtcc tgcgtcctct 5760 gtccccgggt ttcagagaca acttcccaaa gcacaaagca gtttttcccc ctaggggtgg 5820 gaggaagcaa aagactctgt acctattttg tatgtgtata ataatttgag atgtttttaa 5880 ttattttgat tgctggaata aagcatgtgg aaatgaccca aacataa 5927 <210> 190 <211> 5411 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(5411) <223> COL1A2 mRNA <400> 190 gtgtcccata gtgtttccaa acttggaaag ggcgggggag ggcgggagga tgcggagggc 60 ggaggtatgc agacaacgag tcagagtttc cccttgaaag cctcaaaagt gtccacgtcc 120 tcaaaaagaa tggaaccaat ttaagaagcc agccccgtgg ccacgtccct tcccccattc 180 gctccctcct ctgcgccccc gcaggctcct cccagctgtg gctgcccggg cccccagccc 240 cagccctccc attggtggag gcccttttgg aggcacccta gggccaggga aacttttgcc 300 gtataaatag ggcagatccg ggctttatta ttttagcacc acggcagcag gaggtttcgg 360 ctaagttgga ggtactggcc acgactgcat gcccgcgccc gccaggtgat acctccgccg 420 gtgacccagg ggctctgcga cacaaggagt ctgcatgtct aagtgctaga catgctcagc 480 tttgtggata cgcggacttt gttgctgctt gcagtaacct tatgcctagc aacatgccaa 540 tctttacaag aggaaactgt aagaaagggc ccagccggag atagaggacc acgtggagaa 600 aggggtccac caggcccccc aggcagagat ggtgaagatg gtcccacagg ccctcctggt 660 ccacctggtc ctcctggccc ccctggtctc ggtgggaact ttgctgctca gtatgatgga 720 aaaggagttg gacttggccc tggaccaatg ggcttaatgg gacctagagg cccacctggt 780 gcagctggag ccccaggccc tcaaggtttc caaggacctg ctggtgagcc tggtgaacct 840 ggtcaaactg gtcctgcagg tgctcgtggt ccagctggcc ctcctggcaa ggctggtgaa 900 gatggtcacc ctggaaaacc cggacgacct ggtgagagag gagttgttgg accacagggt 960 gctcgtggtt tccctggaac tcctggactt cctggcttca aaggcattag gggacacaat 1020 ggtctggatg gattgaaggg acagcccggt gctcctggtg tgaagggtga acctggtgcc 1080 cctggtgaaa atggaactcc aggtcaaaca ggagcccgtg ggcttcctgg tgagagagga 1140 cgtgttggtg cccctggccc agctggtgcc cgtggcagtg atggaagtgt gggtcccgtg 1200 ggtcctgctg gtcccattgg gtctgctggc cctccaggct tcccaggtgc ccctggcccc 1260 aagggtgaaa ttggagctgt tggtaacgct ggtcctgctg gtcccgccgg tccccgtggt 1320 gaagtgggtc ttccaggcct ctccggcccc gttggacctc ctggtaatcc tggagcaaac 1380 ggccttactg gtgccaaggg tgctgctggc cttcccggcg ttgctggggc tcccggcctc 1440 cctggacccc gcggtattcc tggccctgtt ggtgctgccg gtgctactgg tgccagagga 1500 cttgttggtg agcctggtcc agctggctcc aaaggagaga gcggtaacaa gggtgagccc 1560 ggctctgctg ggccccaagg tcctcctggt cccagtggtg aagaaggaaa gagaggccct 1620 aatggggaag ctggatctgc cggccctcca ggacctcctg ggctgagagg tagtcctggt 1680 tctcgtggtc ttcctggagc tgatggcaga gctggcgtca tgggccctcc tggtagtcgt 1740 ggtgcaagtg gccctgctgg agtccgagga cctaatggag atgctggtcg ccctggggag 1800 cctggtctca tgggacccag aggtcttcct ggttcccctg gaaatatcgg ccccgctgga 1860 aaagaaggtc ctgtcggcct ccctggcatc gacggcaggc ctggcccaat tggcccagct 1920 ggagcaagag gagagcctgg caacattgga ttccctggac ccaaaggccc cactggtgat 1980 cctggcaaaa acggtgataa aggtcatgct ggtcttgctg gtgctcgggg tgctccaggt 2040 cctgatggaa acaatggtgc tcagggacct cctggaccac agggtgttca aggtggaaaa 2100 ggtgaacagg gtccccctgg tcctccaggc ttccagggtc tgcctggccc ctcaggtccc 2160 gctggtgaag ttggcaaacc aggagaaagg ggtctccatg gtgagtttgg tctccctggt 2220 cctgctggtc caagagggga acgcggtccc ccaggtgaga gtggtgctgc cggtcctact 2280 ggtcctattg gaagccgagg tccttctgga cccccagggc ctgatggaaa caagggtgaa 2340 cctggtgtgg ttggtgctgt gggcactgct ggtccatctg gtcctagtgg actcccagga 2400 gagaggggtg ctgctggcat acctggaggc aagggagaaa agggtgaacc tggtctcaga 2460 ggtgaaattg gtaaccctgg cagagatggt gctcgtggtg ctcctggtgc tgtaggtgcc 2520 cctggtcctg ctggagccac aggtgaccgg ggcgaagctg gggctgctgg tcctgctggt 2580 cctgctggtc ctcggggaag ccctggtgaa cgtggtgagg tcggtcctgc tggccccaat 2640 ggatttgctg gtcctgctgg tgctgctggt caacctggtg ctaaaggaga aagaggagcc 2700 aaagggccta agggtgaaaa cggtgttgtt ggtcccacag gccccgttgg agctgctggc 2760 ccagctggtc caaatggtcc ccccggtcct gctggaagtc gtggtgatgg aggcccccct 2820 ggtatgactg gtttccctgg tgctgctgga cggactggtc ccccaggacc ctctggtatt 2880 tctggccctc ctggtccccc tggtcctgct gggaaagaag ggcttcgtgg tcctcgtggt 2940 gaccaaggtc cagttggccg aactggagaa gtaggtgcag ttggtccccc tggcttcgct 3000 ggtgagaagg gtccctctgg agaggctggt actgctggac ctcctggcac tccaggtcct 3060 cagggtcttc ttggtgctcc tggtattctg ggtctccctg gctcgagagg tgaacgtggt 3120 ctaccaggtg ttgctggtgc tgtgggtgaa cctggtcctc ttggcattgc cggccctcct 3180 ggggcccgtg gtcctcctgg tgctgtgggt agtcctggag tcaacggtgc tcctggtgaa 3240 gctggtcgtg atggcaaccc tgggaacgat ggtcccccag gtcgcgatgg tcaacccgga 3300 cacaagggag agcgcggtta ccctggcaat attggtcccg ttggtgctgc aggtgcacct 3360 ggtcctcatg gccccgtggg tcctgctggc aaacatggaa accgtggtga aactggtcct 3420 tctggtcctg ttggtcctgc tggtgctgtt ggcccaagag gtcctagtgg cccacaaggc 3480 attcgtggcg ataagggaga gcccggtgaa aaggggccca gaggtcttcc tggcttaaag 3540 ggacacaatg gattgcaagg tctgcctggt atcgctggtc accatggtga tcaaggtgct 3600 cctggctccg tgggtcctgc tggtcctagg ggccctgctg gtccttctgg ccctgctgga 3660 aaagatggtc gcactggaca tcctggtaca gttggacctg ctggcattcg aggccctcag 3720 ggtcaccaag gccctgctgg cccccctggt ccccctggcc ctcctggacc tccaggtgta 3780 agcggtggtg gttatgactt tggttacgat ggagacttct acagggctga ccagcctcgc 3840 tcagcacctt ctctcagacc caaggactat gaagttgatg ctactctgaa gtctctcaac 3900 aaccagattg agacccttct tactcctgaa ggctctagaa agaacccagc tcgcacatgc 3960 cgtgacttga gactcagcca cccagagtgg agcagtggtt actactggat tgaccctaac 4020 caaggatgca ctatggatgc tatcaaagta tactgtgatt tctctactgg cgaaacctgt 4080 atccgggccc aacctgaaaa catcccagcc aagaactggt ataggagctc caaggacaag 4140 aaacacgtct ggctaggaga aactatcaat gctggcagcc agtttgaata taatgtagaa 4200 ggagtgactt ccaaggaaat ggctacccaa cttgccttca tgcgcctgct ggccaactat 4260 gcctctcaga acatcaccta ccactgcaag aacagcattg catacatgga tgaggagact 4320 ggcaacctga aaaaggctgt cattctacag ggctctaatg atgttgaact tgttgctgag 4380 ggcaacagca ggttcactta cactgttctt gtagatggct gctctaaaaa gacaaatgaa 4440 tggggaaaga caatcattga atacaaaaca aataagccat cacgcctgcc cttccttgat 4500 attgcacctt tggacatcgg tggtgctgac caggaattct ttgtggacat tggcccagtc 4560 tgtttcaaat aaatgaactc aatctaaatt aaaaaagaaa gaaatttgaa aaaactttct 4620 ctttgccatt tcttcttctt cttttttaac tgaaagctga atccttccat ttcttctgca 4680 catctacttg cttaaattgt gggcaaaaga gaaaaagaag gattgatcag agcattgtgc 4740 aatacagttt cattaactcc ttcccccgct cccccaaaaa tttgaatttt tttttcaaca 4800 ctcttacacc tgttatggaa aatgtcaacc tttgtaagaa aaccaaaata aaaattgaaa 4860 aataaaaacc ataaacattt gcaccacttg tggcttttga atatcttcca cagagggaag 4920 tttaaaaccc aaacttccaa aggtttaaac tacctcaaaa cactttccca tgagtgtgat 4980 ccacattgtt aggtgctgac ctagacagag atgaactgag gtccttgttt tgttttgttc 5040 ataatacaaa ggtgctaatt aatagtattt cagatacttg aagaatgttg atggtgctag 5100 aagaatttga gaagaaatac tcctgtattg agttgtatcg tgtggtgtat tttttaaaaa 5160 atttgattta gcattcatat tttccatctt attcccaatt aaaagtatgc agattatttg 5220 cccaaatctt cttcagattc agcatttgtt ctttgccagt ctcattttca tcttcttcca 5280 tggttccaca gaagctttgt ttcttgggca agcagaaaaa ttaaattgta cctattttgt 5340 atatgtgaga tgtttaaata aattgtgaaa aaaatgaaat aaagcatgtt tggttttcca 5400 aaagaacata t 5411 <210> 191 <211> 5490 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(5490) <223> COL3A1 mRNA <400> 191 ggctgagttt tatgacgggc ccggtgctga agggcaggga acaacttgat ggtgctactt 60 tgaactgctt ttcttttctc ctttttgcac aaagagtctc atgtctgata tttagacatg 120 atgagctttg tgcaaaaggg gagctggcta cttctcgctc tgcttcatcc cactattatt 180 ttggcacaac aggaagctgt tgaaggagga tgttcccatc ttggtcagtc ctatgcggat 240 agagatgtct ggaagccaga accatgccaa atatgtgtct gtgactcagg atccgttctc 300 tgcgatgaca taatatgtga cgatcaagaa ttagactgcc ccaacccaga aattccattt 360 ggagaatgtt gtgcagtttg cccacagcct ccaactgctc ctactcgccc tcctaatggt 420 caaggacctc aaggccccaa gggagatcca ggccctcctg gtattcctgg gagaaatggt 480 gaccctggta ttccaggaca accagggtcc cctggttctc ctggcccccc tggaatctgt 540 gaatcatgcc ctactggtcc tcagaactat tctccccagt atgattcata tgatgtcaag 600 tctggagtag cagtaggagg actcgcaggc tatcctggac cagctggccc cccaggccct 660 cccggtcccc ctggtacatc tggtcatcct ggttcccctg gatctccagg ataccaagga 720 ccccctggtg aacctgggca agctggtcct tcaggccctc caggacctcc tggtgctata 780 ggtccatctg gtcctgctgg aaaagatgga gaatcaggta gacccggacg acctggagag 840 cgaggattgc ctggacctcc aggtatcaaa ggtccagctg ggatacctgg attccctggt 900 atgaaaggac acagaggctt cgatggacga aatggagaaa agggtgaaac aggtgctcct 960 ggattaaagg gtgaaaatgg tcttccaggc gaaaatggag ctcctggacc catgggtcca 1020 agaggggctc ctggtgagcg aggacggcca ggacttcctg gggctgcagg tgctcggggt 1080 aatgacggtg ctcgaggcag tgatggtcaa ccaggccctc ctggtcctcc tggaactgcc 1140 ggattccctg gatcccctgg tgctaagggt gaagttggac ctgcagggtc tcctggttca 1200 aatggtgccc ctggacaaag aggagaacct ggacctcagg gacacgctgg tgctcaaggt 1260 cctcctggcc ctcctgggat taatggtagt cctggtggta aaggcgaaat gggtcccgct 1320 ggcattcctg gagctcctgg actgatggga gcccggggtc ctccaggacc agccggtgct 1380 aatggtgctc ctggactgcg aggtggtgca ggtgagcctg gtaagaatgg tgccaaagga 1440 gagcccggac cacgtggtga acgcggtgag gctggtattc caggtgttcc aggagctaaa 1500 ggcgaagatg gcaaggatgg atcacctgga gaacctggtg caaatgggct tccaggagct 1560 gcaggagaaa ggggtgcccc tgggttccga ggacctgctg gaccaaatgg catcccagga 1620 gaaaagggtc ctgctggaga gcgtggtgct ccaggccctg cagggcccag aggagctgct 1680 ggagaacctg gcagagatgg cgtccctgga ggtccaggaa tgaggggcat gcccggaagt 1740 ccaggaggac caggaagtga tgggaaacca gggcctcccg gaagtcaagg agaaagtggt 1800 cgaccaggtc ctcctgggcc atctggtccc cgaggtcagc ctggtgtcat gggcttcccc 1860 ggtcctaaag gaaatgatgg tgctcctggt aagaatggag aacgaggtgg ccctggagga 1920 cctggccctc agggtcctcc tggaaagaat ggtgaaactg gacctcaggg acccccaggg 1980 cctactgggc ctggtggtga caaaggagac acaggacccc ctggtccaca aggattacaa 2040 ggcttgcctg gtacaggtgg tcctccagga gaaaatggaa aacctgggga accaggtcca 2100 aagggtgatg ccggtgcacc tggagctcca ggaggcaagg gtgatgctgg tgcccctggt 2160 gaacgtggac ctcctggatt ggcaggggcc ccaggactta gaggtggagc tggtccccct 2220 ggtcccgaag gaggaaaggg tgctgctggt cctcctgggc cacctggtgc tgctggtact 2280 cctggtctgc aaggaatgcc tggagaaaga ggaggtcttg gaagtcctgg tccaaagggt 2340 gacaagggtg aaccaggcgg tccaggtgct gatggtgtcc cagggaaaga tggcccaagg 2400 ggtcctactg gtcctattgg tcctcctggc ccagctggcc agcctggaga taagggtgaa 2460 ggtggtgccc ccggacttcc aggtatagct ggacctcgtg gtagccctgg tgagagaggt 2520 gaaactggcc ctccaggacc tgctggtttc cctggtgctc ctggacagaa tggtgaacct 2580 ggtggtaaag gagaaagagg ggctccgggt gagaaaggtg aaggaggccc tcctggagtt 2640 gcaggacccc ctggaggttc tggacctgct ggtcctcctg gtccccaagg tgtcaaaggt 2700 gaacgtggca gtcctggtgg acctggtgct gctggcttcc ctggtgctcg tggtcttcct 2760 ggtcctcctg gtagtaatgg taacccagga cccccaggtc ccagcggttc tccaggcaag 2820 gatgggcccc caggtcctgc gggtaacact ggtgctcctg gcagccctgg agtgtctgga 2880 ccaaaaggtg atgctggcca accaggagag aagggatcgc ctggtgccca gggcccacca 2940 ggagctccag gcccacttgg gattgctggg atcactggag cacggggtct tgcaggacca 3000 ccaggcatgc caggtcctag gggaagccct ggccctcagg gtgtcaaggg tgaaagtggg 3060 aaaccaggag ctaacggtct cagtggagaa cgtggtcccc ctggacccca gggtcttcct 3120 ggtctggctg gtacagctgg tgaacctgga agagatggaa accctggatc agatggtctt 3180 ccaggccgag atggatctcc tggtggcaag ggtgatcgtg gtgaaaatgg ctctcctggt 3240 gcccctggcg ctcctggtca tccaggccca cctggtcctg tcggtccagc tggaaagagt 3300 ggtgacagag gagaaagtgg ccctgctggc cctgctggtg ctcccggtcc tgctggttcc 3360 cgaggtgctc ctggtcctca aggcccacgt ggtgacaaag gtgaaacagg tgaacgtgga 3420 gctgctggca tcaaaggaca tcgaggattc cctggtaatc caggtgcccc aggttctcca 3480 ggccctgctg gtcagcaggg tgcaatcggc agtccaggac ctgcaggccc cagaggacct 3540 gttggaccca gtggacctcc tggcaaagat ggaaccagtg gacatccagg tcccattgga 3600 ccaccagggc ctcgaggtaa cagaggtgaa agaggatctg agggctcccc aggccaccca 3660 gggcaaccag gccctcctgg acctcctggt gcccctggtc cttgctgtgg tggtgttgga 3720 gccgctgcca ttgctgggat tggaggtgaa aaagctggcg gttttgcccc gtattatgga 3780 gatgaaccaa tggatttcaa aatcaacacc gatgagatta tgacttcact caagtctgtt 3840 aatggacaaa tagaaagcct cattagtcct gatggttctc gtaaaaaccc cgctagaaac 3900 tgcagagacc tgaaattctg ccatcctgaa ctcaagagtg gagaatactg ggttgaccct 3960 aaccaaggat gcaaattgga tgctatcaag gtattctgta atatggaaac tggggaaaca 4020 tgcataagtg ccaatccttt gaatgttcca cggaaacact ggtggacaga ttctagtgct 4080 gagaagaaac acgtttggtt tggagagtcc atggatggtg gttttcagtt tagctacggc 4140 aatcctgaac ttcctgaaga tgtccttgat gtgcagctgg cattccttcg acttctctcc 4200 agccgagctt cccagaacat cacatatcac tgcaaaaata gcattgcata catggatcag 4260 gccagtggaa atgtaaagaa ggccctgaag ctgatggggt caaatgaagg tgaattcaag 4320 gctgaaggaa atagcaaatt cacctacaca gttctggagg atggttgcac gaaacacact 4380 ggggaatgga gcaaaacagt ctttgaatat cgaacacgca aggctgtgag actacctatt 4440 gtagatattg caccctatga cattggtggt cctgatcaag aatttggtgt ggacgttggc 4500 cctgtttgct ttttataaac caaactctat ctgaaatccc aacaaaaaaa atttaactcc 4560 atatgtgttc ctcttgttct aatcttgtca accagtgcaa gtgaccgaca aaattccagt 4620 tatttatttc caaaatgttt ggaaacagta taatttgaca aagaaaaatg atacttctct 4680 ttttttgctg ttccaccaaa tacaattcaa atgctttttg ttttattttt ttaccaattc 4740 caatttcaaa atgtctcaat ggtgctataa taaataaact tcaacactct ttatgataac 4800 aacactgtgt tatattcttt gaatcctagc ccatctgcag agcaatgact gtgctcacca 4860 gtaaaagata acctttcttt ctgaaatagt caaatacgaa attagaaaag ccctccctat 4920 tttaactacc tcaactggtc agaaacacag attgtattct atgagtccca gaagatgaaa 4980 aaaattttat acgttgataa aacttataaa tttcattgat taatctcctg gaagattggt 5040 ttaaaaagaa aagtgtaatg caagaattta aagaaatatt tttaaagcca caattatttt 5100 aatattggat atcaactgct tgtaaaggtg ctcctctttt ttcttgtcat tgctggtcaa 5160 gattactaat atttgggaag gctttaaaga cgcatgttat ggtgctaatg tactttcact 5220 tttaaactct agatcagaat tgttgacttg cattcagaac ataaatgcac aaaatctgta 5280 catgtctccc atcagaaaga ttcattggca tgccacaggg gattctcctc cttcatcctg 5340 taaaggtcaa caataaaaac caaattatgg ggctgctttt gtcacactag catagagaat 5400 gtgttgaaat ttaactttgt aagcttgtat gtggttgttg atcttttttt tccttacaga 5460 cacccataat aaaatatcat attaaaattc 5490 <210> 192 <211> 6540 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6540) <223> COL4A1 mRNA <400> 192 aggtctccgc ttggagccgc cgcacccggg acggtgcgta gcgctggaag tccggccttc 60 cgagagctag ctgtccgccg cggcccccgc acgccgggca gccgtccctc gccgcctcgg 120 gcgcgccacc atggggcccc ggctcagcgt ctggctgctg ctgctgcccg ccgcccttct 180 gctccacgag gagcacagcc gggccgctgc gaagggtggc tgtgctggct ctggctgtgg 240 caaatgtgac tgccatggag tgaagggaca aaagggtgaa agaggcctcc cggggttaca 300 aggtgtcatt gggtttcctg gaatgcaagg acctgagggg ccacagggac caccaggaca 360 aaagggtgat actggagaac caggactacc tggaacaaaa gggacaagag gacctccggg 420 agcatctggc taccctggaa acccaggact tcccggaatt cctggccaag acggcccgcc 480 aggcccccca ggtattccag gatgcaatgg cacaaagggg gagagagggc cgctcgggcc 540 tcctggcttg cctggtttcg ctggaaatcc cggaccacca ggcttaccag ggatgaaggg 600 tgatccaggt gagatacttg gccatgtgcc cgggatgctg ttgaaaggtg aaagaggatt 660 tcccggaatc ccagggactc caggcccacc aggactgcca gggcttcaag gtcctgttgg 720 gcctccagga tttaccggac caccaggtcc cccaggccct cccggccctc caggtgaaaa 780 gggacaaatg ggcttaagtt ttcaaggacc aaaaggtgac aagggtgacc aaggggtcag 840 tgggcctcca ggagtaccag gacaagctca agttcaagaa aaaggagact tcgccaccaa 900 gggagaaaag ggccaaaaag gtgaacctgg atttcagggg atgccagggg tcggagagaa 960 aggtgaaccc ggaaaaccag gacccagagg caaacccgga aaagatggtg acaaagggga 1020 aaaagggagt cccggttttc ctggtgaacc cgggtaccca ggactcatag gccgccaggg 1080 cccgcaggga gaaaagggtg aagcaggtcc tcctggccca cctggaattg ttataggcac 1140 aggacctttg ggagaaaaag gagagagggg ctaccctgga actccggggc caagaggaga 1200 gccaggccca aaaggtttcc caggactacc aggccaaccc ggacctccag gcctccctgt 1260 acctgggcag gctggtgccc ctggcttccc tggtgaaaga ggagaaaaag gtgaccgagg 1320 atttcctggt acatctctgc caggaccaag tggaagagat gggctcccgg gtcctcctgg 1380 ttcccctggg ccccctgggc agcctggcta cacaaatgga attgtggaat gtcagcccgg 1440 acctccaggt gaccagggtc ctcctggaat tccagggcag ccaggattta taggcgaaat 1500 tggagagaaa ggtcaaaaag gagagagttg cctcatctgt gatatagacg gatatcgggg 1560 gcctcccggg ccacagggac ccccgggaga aataggtttc ccagggcagc caggggccaa 1620 gggcgacaga ggtttgcctg gcagagatgg tgttgcagga gtgccaggcc ctcaaggtac 1680 accagggctg ataggccagc caggagccaa gggggagcct ggtgagtttt atttcgactt 1740 gcggctcaaa ggtgacaaag gagacccagg ctttccagga cagcccggca tgccagggag 1800 agcgggttct cctggaagag atggccatcc gggtcttcct ggccccaagg gctcgccggg 1860 ttctgtagga ttgaaaggag agcgtggccc ccctggagga gttggattcc caggcagtcg 1920 tggtgacacc ggcccccctg ggcctccagg atatggtcct gctggtccca ttggtgacaa 1980 aggacaagca ggctttcctg gaggccctgg atccccaggc ctgccaggtc caaagggtga 2040 accaggaaaa attgttcctt taccaggccc ccctggagca gaaggactgc cggggtcccc 2100 aggcttccca ggtccccaag gagaccgagg ctttcccgga accccaggaa ggccaggcct 2160 gccaggagag aagggcgctg tgggccagcc aggcattgga tttccagggc cccccggccc 2220 caaaggtgtt gacggcttac ctggagacat ggggccaccg gggactccag gtcgcccggg 2280 atttaatggc ttacctggga acccaggtgt gcagggccag aagggagagc ctggagttgg 2340 tctaccggga ctcaaaggtt tgccaggtct tcccggcatt cctggcacac ccggggagaa 2400 ggggagcatt ggggtaccag gcgttcctgg agaacatgga gcgatcggac cccctgggct 2460 tcaggggatc agaggtgaac cgggacctcc tggattgcca ggctccgtgg ggtctccagg 2520 agttccagga ataggccccc ctggagctag gggtccccct ggaggacagg gaccaccggg 2580 gttgtcaggc cctcctggaa taaaaggaga gaagggtttc cccggattcc ctggactgga 2640 catgccgggc cctaaaggag ataaaggggc tcaaggactc cctggcataa cgggacagtc 2700 ggggctccct ggccttcctg gacagcaggg ggctcctggg attcctgggt ttccaggttc 2760 caagggagaa atgggcgtca tggggacccc cgggcagccg ggctcaccag gaccagtggg 2820 tgctcctgga ttaccgggtg aaaaagggga ccatggcttt ccgggctcct caggacccag 2880 gggagaccct ggcttgaaag gtgataaggg ggatgtcggt ctccctggca agcctggctc 2940 catggataag gtggacatgg gcagcatgaa gggccagaaa ggagaccaag gagagaaagg 3000 acaaattgga ccaattggtg agaagggatc ccgaggagac cctgggaccc caggagtgcc 3060 tggaaaggac gggcaggcag gacagcctgg gcagccagga cctaaaggtg atccaggtat 3120 aagtggaacc ccaggtgctc caggacttcc gggaccaaaa ggatctgttg gtggaatggg 3180 cttgccagga acacctggag agaaaggtgt gcctggcatc cctggcccac aaggttcacc 3240 tggcttacct ggagacaaag gtgcaaaagg agagaaaggg caggcaggcc cacctggcat 3300 aggcatccca gggctgcgag gtgaaaaggg agatcaaggg atagcgggtt tcccaggaag 3360 ccctggagag aagggagaaa aaggaagcat tgggatccca ggaatgccag ggtccccagg 3420 ccttaaaggg tctcccggga gtgttggcta tccaggaagt cctgggctac ctggagaaaa 3480 aggtgacaaa ggcctcccag gattggatgg catccctggt gtcaaaggag aagcaggtct 3540 tcctgggact cctggcccca caggcccagc tggccagaaa ggggagccag gcagtgatgg 3600 aatcccgggg tcagcaggag agaagggtga accaggtcta ccaggaagag gattcccagg 3660 gtttccaggg gccaaaggag acaaaggttc aaagggtgag gtgggtttcc caggattagc 3720 cgggagccca ggaattcctg gatccaaagg agagcaagga ttcatgggtc ctccggggcc 3780 ccagggacag ccggggttac cgggatcccc aggccatgcc acggaggggc ccaaaggaga 3840 ccgcggacct cagggccagc ctggcctgcc aggacttccg ggacccatgg ggcctccagg 3900 gcttcctggg attgatggag ttaaaggtga caaaggaaat ccaggctggc caggagcacc 3960 cggtgtccca gggcccaagg gagaccctgg attccagggc atgcctggta ttggtggctc 4020 tccaggaatc acaggctcta agggtgatat ggggcctcca ggagttccag gatttcaagg 4080 tccaaaaggt cttcctggcc tccagggaat taaaggtgat caaggcgatc aaggcgtccc 4140 gggagctaaa ggtctcccgg gtcctcctgg ccccccaggt ccttacgaca tcatcaaagg 4200 ggagcccggg ctccctggtc ctgagggccc cccagggctg aaagggcttc agggactgcc 4260 aggcccgaaa ggccagcaag gtgttacagg attggtgggt atacctggac ctccaggtat 4320 tcctgggttt gacggtgccc ctggccagaa aggagagatg ggacctgccg ggcctactgg 4380 tccaagagga tttccaggtc caccaggccc cgatgggttg ccaggatcca tggggccccc 4440 aggcacccca tctgttgatc acggcttcct tgtgaccagg catagtcaaa caatagatga 4500 cccacagtgt ccttctggga ccaaaattct ttaccacggg tactctttgc tctacgtgca 4560 aggcaatgaa cgggcccatg gccaggactt gggcacggcc ggcagctgcc tgcgcaagtt 4620 cagcacaatg cccttcctgt tctgcaatat taacaacgtg tgcaactttg catcacgaaa 4680 tgactactcg tactggctgt ccacccctga gcccatgccc atgtcaatgg cacccatcac 4740 gggggaaaac ataagaccat ttattagtag gtgtgctgtg tgtgaggcgc ctgccatggt 4800 gatggccgtg cacagccaga ccattcagat cccaccgtgc cccagcgggt ggtcctcgct 4860 gtggatcggc tactcttttg tgatgcacac cagcgctggt gcagaaggct ctggccaagc 4920 cctggcgtcc cccggctcct gcctggagga gtttagaagt gcgccattca tcgagtgtca 4980 cggccgtggg acctgcaatt actacgcaaa cgcttacagc ttttggctcg ccaccataga 5040 gaggagcgag atgttcaaga agcctacgcc gtccaccttg aaggcagggg agctgcgcac 5100 gcacgtcagc cgctgccaag tctgtatgag aagaacataa tgaagcctga ctcagctaat 5160 gtcacaacat ggtgctactt cttcttcttt ttgttaacag caacgaaccc tagaaatata 5220 tcctgtgtac ctcactgtcc aatatgaaaa ccgtaaagtg ccttatagga atttgcgtaa 5280 ctaacacacc ctgcttcatt gacctctact tgctgaagga gaaaaagaca gcgataagct 5340 ttcaatagtg gcataccaaa tggcactttt gatgaaataa aatatcaata ttttctgcaa 5400 tccaatgcac tgatgtgtga agtgagaact ccatcagaaa accaaagggt gctaggaggt 5460 gtgggtgcct tccatactgt ttgcccattt tcattcttgt attataatta attttctacc 5520 cccagagata aatgtttgtt tatatcactg tctagctgtt tcaaaattta ggtcccttgg 5580 tctgtacaaa taatagcaat gtaaaaatgg ttttttgaac ctccaaatgg aattacagac 5640 tcagtagcca tatcttccaa ccccccagta taaatttctg tctttctgct atgtgtggta 5700 ctttgcagct gcttttgcag aaatcacaat tttcctgtgg aataaagatg gtccaaaaat 5760 agtcaaaaat taaatatata tatatattag taatttatat agatgtcagc aattaggcag 5820 atcaaggttt agtttaactt ccactgttaa aataaagctt acatagtttt cttcctttga 5880 aagactgtgc tgtcctttaa cataggtttt taaagactag gatattgaat gtgaaacatc 5940 cgttttcatt gttcacttct aaaccaaaaa ttatgtgttg ccaaaaccaa acccaggttc 6000 atgaatatgg tgtctattat agtgaaacat gtactttgag cttattgttt ttattctgta 6060 ttaaatattt tcagggtttt aaacactaat cacaaactga atgacttgac ttcaaaagca 6120 acaaccttaa aggccgtcat ttcattagta ttcctcattc tgcatcctgg cttgaaaaac 6180 agctctgttg aatcacagta tcagtatttt cacacgtaag cacattcggg ccatttccgt 6240 ggtttctcat gagctgtgtt cacagacctc agcagggcat cgcatggacc gcaggagggc 6300 agattcggac cactaggcct gaaatgacat ttcactaaaa gtctccaaaa catttctaag 6360 actactaagg ccttttatgt aatttcttta aatgtgtatt tcttaagaat tcaaatttgt 6420 aataaaacta tttgtataaa aattaagctt ttattaattt gttgctagta ttgccacaga 6480 cgcattaaaa gaaacttact gcacaagctg ctaataaatt tgtaagcttt gcatacctta 6540 6540 <210> 193 <211> 8455 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(8455) <223> COL5A1 mRNA <400> 193 ccgcactctc cgtccccgcg gctggcgcag gacctcactc gagcggagcg cccacgggga 60 gcgggtcgcg gggcggcggc ggcgaggagg aggcgagaag gagttggagg aggaggagga 120 ggaggcgagg gcgagctagc ccagcggggt cccggccgcc ccgcgggcca aagtcgagcc 180 ctcccgcccg tgggcgagcg cgccagccgc cccttccaga acagccgccg ccacaaagaa 240 gaacgggggg tgccgaggtc cccatgacct cctaaagtgg tgcggtccct gctgagtgcg 300 ctgcccgggc cgtgacccgc gcccctgtgc gtccccgcgc gcctccgagc gcccctgtgc 360 gccccggccc gcgccccgcc ggcatggacg tccatacccg ctggaaagcg cgcagcgcgc 420 tccgcccggg cgccccgctg ctgcccccgc tgctgctgct gctgctgtgg gcgccgcctc 480 cgagccgcgc agctcagcca gcagatctcc tgaaggttct agattttcac aacttgcctg 540 atggaataac aaagacaaca ggcttttgcg ccacgcggcg atcttccaaa ggcccggatg 600 tcgcttacag agtcaccaaa gacgcgcagc tcagcgcacc caccaagcag ctgtaccctg 660 cgtctgcatt tcccgaggac ttctccatcc taacaactgt gaaagccaag aaaggcagcc 720 aggccttcct ggtctccatc tacaacgagc agggtatcca gcagattggg ctggagctgg 780 gccgctctcc cgtcttcctc tacgaggacc acacggggaa gcctggcccg gaagactacc 840 ccctcttccg gggcatcaac ctgtcagatg gcaagtggca cagaattgct ctcagcgtcc 900 acaagaaaaa tgtcaccttg atcctcgact gtaaaaagaa gaccaccaaa ttcctcgacc 960 gcagcgacca ccccatgatc gacatcaatg gcatcatcgt gtttggcacc cggatcctgg 1020 atgaggaggt gtttgagggt gacatccagc agctgctctt tgtctcggac caccgggcag 1080 cttatgatta ctgtgagcac tacagccctg actgtgacac cgcagtacct gacaccccac 1140 agtcgcagga ccccaatcca gatgaatatt acacggaagg agacggcgag ggtgagacct 1200 attactacga atacccctac tacgaagacc ccgaagacct agggaaggag cccaccccca 1260 gcaagaagcc cgtggaagct gccaaagaaa ccacagaggt ccccgaggag ctgaccccga 1320 cccccacgga agctgctccc atgcctgaaa ccagtgaagg ggctgggaag gaagaggacg 1380 tcggcatcgg ggactatgac tacgtgccca gtgaggacta ctacacgccc tcaccgtatg 1440 atgacctcac ctatggcgag ggggaggaga accccgacca gcccacagac ccaggcgctg 1500 gggccgaaat tcccaccagc accgccgaca cctccaactc ctccaatcca gctccgcctc 1560 caggggaagg tgcggatgac ttggaggggg agttcactga ggaaacgatc cggaaccttg 1620 acgagaacta ctacgacccc tactacgacc ccaccagctc cccgtcggag atcgggccgg 1680 gaatgccggc gaaccaggat accatctatg aagggattgg aggacctcgg ggcgagaaag 1740 gccaaaaggg agaaccagcg attatcgagc cgggcatgct catcgagggc ccgcctggcc 1800 cagaaggccc cgcgggtctt cccggacctc caggaaccat gggtcccact ggccaagtcg 1860 gggaccctgg agaaaggggc ccccctggac gcccaggcct tcctggggcc gatggcctgc 1920 ccggtcctcc aggaaccatg ctcatgctgc ccttccggtt tggaggtggc ggcgatgcgg 1980 gctccaaagg ccccatggtc tcagcccagg agtcccaggc gcaagccatt ctccagcagg 2040 ccaggttggc actgagggga ccagctggcc cgatgggtct cacagggaga cctggccctg 2100 tgggtccccc tgggagcgga ggtttgaagg gcgagccggg agacgtgggg cctcagggtc 2160 ctcgaggtgt gcaaggcccg cctggtccgg ccgggaagcc cggaagacgg ggtcgggctg 2220 ggagtgatgg agccagagga atgcctggac aaactggccc caagggtgac cggggtttcg 2280 acggcctggc tgggttgcca ggcgagaagg gccacagggg tgaccctggt ccttccggcc 2340 caccaggacc tccgggagac gatggagaaa ggggtgacga cggagaagtt gggcccaggg 2400 ggctgcctgg ggagcccggg ccacgtggtc tgcttgggcc gaaggggccc ccaggtcctc 2460 ccggacctcc cggtgtcacg ggtatggacg gccagccggg gccaaaagga aatgtgggtc 2520 cccagggaga gcctggcccc ccaggacagc agggtaatcc aggcgcccag ggtcttccag 2580 gcccccaggg tgcaattggt cctccaggag aaaagggtcc cttggggaaa ccaggccttc 2640 caggaatgcc cggtgctgac ggacccccgg gacaccctgg caaagaaggc cctccaggag 2700 agaaaggagg tcagggtcca cctggccccc agggtccgat tggctaccca ggtcctcgag 2760 gagtcaaggg ggccgatggc atccgtggtc tgaagggcac aaagggcgag aagggtgaag 2820 acggctttcc tgggtttaaa ggagacatgg gcatcaaggg tgatcggggg gagatcggcc 2880 cacccggtcc caggggagaa gatggccctg aaggcccaaa gggtcgcgga ggtcccaatg 2940 gtgaccccgg tcctctggga ccccctgggg agaagggaaa actcggagtc ccagggttac 3000 cagggtatcc aggaagacaa ggaccaaagg gctctattgg attccctgga tttcctggcg 3060 ccaatggaga gaagggcggc agggggaccc ctggaaagcc aggaccgcgg gggcagcgag 3120 gcccaacggg tccgaggggt gaaagaggcc cccggggcat cactgggaag cctggcccca 3180 agggcaactc cggaggtgac ggcccagctg gccctcctgg tgaacgggga cccaatggac 3240 cccaaggacc cacaggattt cctggaccaa agggcccccc tggccctcca ggcaaggatg 3300 gactcccagg acaccctgga cagagaggcg agactggttt ccaaggcaag accggccctc 3360 caggcccccc cggcgtggtc ggccctcagg gtcccacggg agaaacgggc ccaatgggtg 3420 agcgtggcca ccctgggccc cctggacccc ccggtgaaca ggggcttccg ggccttgctg 3480 gaaaagaagg gacgaagggt gacccaggcc ctgcaggcct ccctgggaaa gatggccctc 3540 caggattacg tggtttccct ggggaccgag ggcttcctgg tccagtggga gctcttggac 3600 tgaaaggcaa tgaagggccc cctggcccac caggccctgc gggatctcca ggggagagag 3660 gtccagctgg agccgctggg cccatcggaa ttccagggag acctgggccc cagggacccc 3720 cagggccggc aggagagaaa ggggctcctg gcgagaaagg cccacaaggc ccagctggcc 3780 gagacggtct ccaggggcct gtggggctcc cgggtccagc tggccctgtg ggtccccctg 3840 gagaagacgg agataaggga gagatcgggg agccggggca gaaaggaagc aagggggaca 3900 aaggagaaca gggtcctcct gggcctacag gtcctcaagg ccccatcgga cagccaggcc 3960 cctctggagc tgacggcgag ccggggcctc ggggccagca gggccttttc gggcagaaag 4020 gtgatgaagg tcccagaggc tttcctggac cccctgggcc agtggggctg cagggtttgc 4080 caggacctcc aggcgagaag ggtgagacag gagacgtggg ccagatgggc cccccgggtc 4140 cccctggccc ccgaggaccc tccggagctc caggtgctga tggcccacaa ggtcccccag 4200 gtggaatagg aaaccctggt gcagtgggag agaagggcga gcctggcgaa gcaggtgagc 4260 ctggccttcc gggagaaggc ggccccccgg gacccaaagg agaaagggga gagaagggcg 4320 agtcaggccc ttcaggtgct gccggacccc ctggacccaa aggccctccc ggagatgatg 4380 gtcccaaagg cagccctggc ccagtgggtt ttcctggaga tcctggcccc cccggagagc 4440 ctggccccgc gggtcaagat ggtccccctg gtgacaaagg agatgatggt gaacccgggc 4500 agacgggatc ccccggccct actggtgaac caggtccatc ggggcctcca ggaaaaaggg 4560 gtcccccagg ccccgcaggc cccgaaggca gacagggaga gaaaggggcc aagggagaag 4620 ccggcttgga aggccctcct gggaagactg gccccatcgg cccccagggg gcccctggga 4680 agcccggacc ggatggcctt cgagggatcc ctggccctgt gggagaacaa ggtctcccag 4740 gatccccagg cccggacggt ccccccggcc ccatgggtcc cccaggactt cccggcctca 4800 aaggagattc tggtcccaaa ggtgaaaagg gtcatccagg cctgatcggg ctcatcggtc 4860 ctccgggtga acagggtgag aagggcgacc gtggtctccc tggcccccag ggctcctccg 4920 gtcctaaggg agaacagggt atcactggtc cttctggccc gattgggcct cctgggcccc 4980 ctggcctgcc gggtccgcct ggtccaaaag gtgctaaggg ctcctcgggt ccaactggcc 5040 cgaagggtga ggcaggccac ccaggacccc caggcccccc gggccccccg ggagaggtca 5100 tccagcccct gccaatccag gcatccagga cgcggcggaa catcgacgcc agccagctgc 5160 tggacgacgg gaatggcgag aactacgtgg actacgcgga cggcatggaa gagatcttcg 5220 gctctctcaa ctctctgaag ctggagattg agcagatgaa acggcccctg ggcacgcagc 5280 agaaccccgc ccgcacctgc aaggacctgc agctctgcca ccccgacttc ccagatggtg 5340 aatactgggt cgatcctaac caaggatgct ccagggattc cttcaaggtt tactgcaact 5400 tcacagccgg ggggtcgaca tgcgtcttcc ctgacaagaa gtccgaaggg gccagaatca 5460 cttcttggcc caaagaaaac ccgggctcct ggttcagtga attcaagcgt gggaaactgc 5520 tctcctatgt ggacgccgag ggcaaccctg tgggtgtggt acagatgacc ttcctgcggc 5580 tgctgagcgc ctctgcccac cagaacgtca cctaccactg ctaccagtca gtggcctggc 5640 aggacgcagc cacgggcagc tacgacaagg ccctccgctt cctgggctcc aacgacgagg 5700 agatgtccta tgacaacaac ccctacatcc gcgccctggt ggacggctgt gctaccaaga 5760 aaggctacca gaagacggtt ctggagatcg acacccccaa agtggagcag gtgcccatcg 5820 tggacatcat gttcaatgac ttcggtgaag cgtcacagaa atttggattt gaagtggggc 5880 cggcttgctt catgggctag gagccgccga gcccgggctc ccgagagcaa cctcgtgacc 5940 tcagcatgcc attcgttcgt gagtgtcccg tgcacgtcct gaccctggac agtgaaggct 6000 tctccctccc ctcccacctg acttcatcta cgcctcggca ccacggggtg tgggacccca 6060 gcccggagag aacagaggga aggagccgcg cccccacctg gagctgaatc acatgaccta 6120 gctgcacccc agcgcctggg cccgccccac gctctgtcca cacccacgcg ccccgggagc 6180 ggggccatgc ctccagcccc ccagctcgcc cgacccatcc tgttcgtgaa taggtctcag 6240 gggttggggg agggactgcc agatttggac actatatttt tttctaaatt caacttgaag 6300 atgtgtattt cccctgacct tcaaaaaatg ttccaaggta agcctcgtaa aggtcatccc 6360 accatcacca aagcctccgt ttttaacaac ctccaacacg atccatttag aggccaaatg 6420 tcattctgca ggtgccttcc cgatggatta aaggtgctta tgtttttgtg agttttaagt 6480 aaatatttgt attgtattgt tataaatgtt aagtgtgcct ggctttcaat catgcacgga 6540 aacccagtct cagtcccacg gacagaatgg gcgaggcatg gattctgggt tgcagtaccg 6600 ttctgattag aaataggaag tctccccacc cccgccctgg ccaagaacgt gcaataaatt 6660 ggaagtttgc cccggggcag caagaattta tgctgccatt gaaaagcagg taccagtgcc 6720 ccttttcaga cagtttttga ttcgctctag actttttttt tttttaatag ggaaaaaatt 6780 tgataatttt cttttttcta catgcactta agactaaaac acaggtttgg attaatttta 6840 tttgcttcct ttttccgctt ttcttcccgc agagcctgat gggagaatgt ccagggcagg 6900 gaaaccacat tttttgtagg tgataactca atgaaaattg gtgcttattt tttacacttc 6960 tctcttgtgg ctctcttgtg gtgctatcta tctgttttaa ggtctccttg aaggcgcact 7020 ggggaccctg gccatgcctc gttctccctg ctttctttat cctgttattg cctccacagt 7080 ctgttgccaa ggactctaag atcaatgcac gtcactttcc tttccactgg gcaggatagc 7140 caagcacact ccctcctgcg ctctcccgcc ccggtgcgtc cactcccgag ggctgttatg 7200 aggactgggt tgtgcctact tgatttgaaa acacacacaa gcaataaaaa gcctcttcct 7260 gcattgtctg tggtgtgacc atagcagatt atatttggtt cctgaatgtt tgtggtgcta 7320 atttctgtgt ttgttccaag ccgttcagtc atgccatgcg ctgcctcggt agatggagta 7380 atgtacaatg aactccatga gtctctccag ggctgcctgc agcacgtctt ttccaagtag 7440 cctatttgga ttcccatctc aaatgtcctg gatgcgagcg tcagcggctc cagagctcgg 7500 ggcgggtgag gtcccctttg gggaaccctt tcctggccat cgaggtcggg gggctgccgt 7560 ctgtgggcag gaggacccga ggggcagcca ggaaaggcga tctcttcact gtgaaaagtt 7620 gcccgggtgc agcgcctttt ccttctacca tgggaaatgc aggctgggcc cttggggtga 7680 gcctgcgggg ctctggtgct gtccccgacc cccaccacca ccagaatgca gttccagctt 7740 aggaagccac aaacaagcca cccaggagga acaaaacacc gccagcgtgg attttccaaa 7800 tttccctgga aagtaagtct cgctcttgcc aaagaaaagt ctggcttgga gagtctctgg 7860 agcccaggat gccagcatgt gccaatgact gtcaccttca tctcttcaaa agaaaagcca 7920 tagccgagga ctgtcccgcg acccccgtgg actgcgtcta ggtcatgtga ttctgttttc 7980 atttctcatc ccatccaatt tgtccttttc tcctgtcatt ttcttcctct gtggtccctt 8040 caaagttgtt ataatttgta ctgaacttca aaatgtgtcc cgttctcccc agaccactct 8100 agccacagta tattgcaata aaattacttc ttatatttgc agaaattctt ttggtgtaat 8160 tttatttttt cctctcaata tatataattg gacaaacgct ggcaaaaaga aaaaaatggt 8220 aagcaaaaaa cccaagataa agtttcgagg acatcaggcc ttttgaaata caatgtcaaa 8280 tgacacattg tacggtttca aaaaatccgc tagacatgtc ataagtttta actgtaatgc 8340 ccaggaaagg atatcttaaa atattctaaa cttgtgtaac aaaggaataa ttaactgtaa 8400 tagtttttca ataaatcgag ttgggtgttt ccaccgtaaa aaaaaaaaaa aaaaa 8455 <210> 194 <211> 6829 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6829) <223> COL5A2 mRNA <400> 194 gcagactgtg ctggagctgg tgctgaaaaa gggggtttgc agaggctgcc ctggggctgg 60 tgctgaaaga agagcccaca gctgacttca tggtgctaca ataacctcag aatctacttt 120 tcactctcag gagaacccac atgtctaata tttagacatg atggcaaact gggcggaagc 180 aagacctctc ctcattctta ttgttttatt agggcaattt gtctcaataa aagcccagga 240 agaagacgag gatgaaggat atggtgaaga aatagcctgc actcagaatg gccagatgta 300 cttaaacagg gacatttgga aacctgcccc ttgtcagatc tgtgtctgtg acaatggagc 360 cattctctgt gacaagatag aatgccagga tgtgctggac tgtgccgacc ctgtaacgcc 420 ccctggggaa tgctgtcctg tctgttcaca aacacctgga ggtggcaata ccaattttgg 480 tagaggaaga aagggacaaa agggagaacc aggattagtg cctgttgtaa caggcatacg 540 tggtcgtcca ggaccggcag gacctccagg atcacaggga ccaagaggag agcgagggcc 600 aaaaggaaga cctggccctc gtggacctca gggaattgat ggagaaccag gtgttcctgg 660 tcaacctggt gctccaggac ctcctggaca tccgtcccac ccaggacccg atggcttgag 720 caggccgttt tcagctcaaa tggctgggtt ggatgaaaaa tctggacttg ggagtcaagt 780 aggactaatg cctggctctg tgggtcctgt tggcccaagg ggaccacagg gtttacaagg 840 acagcaaggt ggtgcaggac ctacaggacc tcctggtgaa cctggtgatc ctggaccaat 900 gggtccgatt ggttcacgtg gaccagaggg ccctcctggt aaacctgggg aagatggtga 960 acctggcaga aatggaaatc ctggtgaagt gggatttgca ggatctccgg gagctcgtgg 1020 atttcctggg gctcctggtc ttccaggtct gaagggtcac cgaggacaca aaggtcttga 1080 aggccctaaa ggtgaagttg gagcacctgg ttccaagggt gaagctggcc ccactggtcc 1140 aatgggtgcc atgggtcctc tgggtccgag gggaatgcca ggagagagag ggagacttgg 1200 gccacagggt gctcctggac aacgaggtgc acatggtatg cctggaaaac ctggaccaat 1260 gggtcctctt gggataccag gctcttctgg ttttccagga aatcctggaa tgaagggaga 1320 agcaggtcct acaggggcgc gaggccctga aggtcctcag gggcagagag gtgaaactgg 1380 gcccccaggt ccagttggct ctccaggtct tcctggtgca ataggaactg atggtactcc 1440 tggtgccaaa ggcccaacgg gctctccagg tacctctggt cctcctggct cagcagggcc 1500 tcctggatct ccaggacctc agggtagcac tggtcctcag ggaattcgag gccaaccggg 1560 tgatccagga gttccaggtt tcaaaggaga agctggccca aaaggggaac cagggccaca 1620 tggtattcag ggtccgatag gcccacccgg tgaagaaggc aaaagaggtc ccagaggtga 1680 cccaggaaca gttggtcctc cagggccagt gggagaaagg ggtgctcctg gcaatcgtgg 1740 ttttccaggc tctgatggtt tacctgggcc aaagggtgct caaggagaac ggggtcctgt 1800 aggttcttca ggacccaaag gaagccaggg ggatccagga cgtccagggg aacctgggct 1860 tccaggtgct cggggtttga caggaaatcc tggtgttcaa ggtcctgaag gaaaacttgg 1920 acctttgggt gcgccagggg aagatggccg tccaggtcct ccaggctcca taggaatcag 1980 agggcagccc gggagcatgg gccttccagg ccccaaaggt agcagtggtg accctgggaa 2040 acctggagaa gcaggaaatg ctggagttcc tgggcagagg ggagctcctg gaaaagatgg 2100 tgaagttggt ccttctggtc ctgtgggccc gccgggtcta gctggtgaaa gaggagaaca 2160 aggacctcca ggccccacag gttttcaggg gcttcctggt cctccagggc ctcctggaga 2220 aggtggaaaa ccaggtgatc aaggtgttcc tggagatccc ggagcagttg gcccgttagg 2280 acctagagga gaacgaggaa atcctgggga aagaggagaa cctgggataa ctggactccc 2340 tggtgagaag ggaatggctg gaggacatgg tcctgatggc ccaaaaggca gtccaggtcc 2400 atctgggacc cctggagata caggcccacc aggtcttcaa ggtatgccgg gagaaagagg 2460 aattgcagga actcctggcc ccaagggtga cagaggtggc ataggagaaa aaggtgctga 2520 aggcacagct ggaaatgatg gtgcaagagg tcttccaggt cctttgggcc ctccaggtcc 2580 ggcaggtcct actggagaaa agggtgaacc tggtcctcga ggtttagttg gccctcctgg 2640 ctcccggggc aatcctggtt ctcgaggtga aaatgggcca actggagctg ttggttttgc 2700 cggaccccag ggtcctgacg gacagcctgg agtaaaaggt gaacctggag agccaggaca 2760 gaagggagat gctggttctc ctggaccaca aggtttagca ggatcccctg gccctcatgg 2820 tcctaatggt gttcctggac taaaaggtgg tcgaggaacc caaggtccgc ctggtgctac 2880 aggatttcct ggttctgcgg gcagagttgg acctccaggc cctgctggag ctccaggacc 2940 tgcgggaccc ctaggggaac ccgggaagga gggacctcca ggtcttcgtg gggaccctgg 3000 ctctcatggg cgtgtgggag atcgaggacc agctggcccc cctggtggcc caggagacaa 3060 aggggaccca ggagaagatg ggcaacctgg tccagatggc ccccctggtc cagctggaac 3120 gaccgggcag agaggaattg ttggcatgcc tgggcaacgt ggagagagag gcatgcccgg 3180 cctaccaggc ccagcgggaa caccaggaaa agtaggacca actggtgcaa caggagataa 3240 aggtccacct ggacctgtgg ggcccccagg ctccaatggt cctgtagggg aacctggacc 3300 agaaggtcca gctggcaatg atggtacccc aggacgggat ggtgctgttg gagaacgtgg 3360 tgatcgtgga gaccctgggc ctgcaggtct gccaggctct cagggtgccc ctggaactcc 3420 tggccctgtg ggtgctccag gagatgcagg acaaagagga gatccgggtt ctcggggtcc 3480 tataggacca cctggtcgag ctgggaaacg tggattacct ggaccccaag gacctcgtgg 3540 tgacaaaggt gatcatggag accgaggtga cagaggtcag aagggccaca gaggctttac 3600 tggtcttcag ggtcttcctg gccctcctgg tccaaatggt gaacaaggaa gtgctggaat 3660 ccctggacca tttggcccaa gaggtcctcc aggcccagtt ggtccttcag gtaaagaagg 3720 aaaccctggg ccacttgggc caattggacc tccaggtgta cgaggcagtg taggagaagc 3780 aggacctgag ggccctcctg gtgagcctgg cccacctggc cctccgggtc cccctggcca 3840 ccttacagct gctcttgggg atatcatggg gcactatgat gaaagcatgc cagatccact 3900 tcctgagttt actgaagatc aggcggctcc tgatgacaaa aacaaaacgg acccaggggt 3960 tcatgctacc ctgaagtcac tcagtagtca gattgaaacc atgcgcagcc ccgatggctc 4020 gaaaaagcac ccagcccgca cgtgtgatga cctaaagctt tgccattccg caaagcagag 4080 tggtgaatac tggattgatc ctaaccaagg atctgttgaa gatgcaatca aagtttactg 4140 caacatggaa acaggagaaa catgtatttc agcaaaccca tccagtgtac cacgtaaaac 4200 ctggtgggcc agtaaatctc ctgacaataa acctgtttgg tatggtcttg atatgaacag 4260 agggtctcag ttcgcttatg gagaccacca atcacctaat acagccatta ctcagatgac 4320 ttttttgcgc cttttatcaa aagaagcctc ccagaacatc acttacatct gtaaaaacag 4380 tgtaggatac atggacgatc aagctaagaa cctcaaaaaa gctgtggttc tcaaaggggc 4440 aaatgactta gatatcaaag cagagggaaa tattagattc cggtatatcg ttcttcaaga 4500 cacttgctct aagcggaatg gaaatgtggg caagactgtc tttgaatata gaacacagaa 4560 tgtggcacgc ttgcccatca tagatcttgc tcctgtggat gttggcggca cagaccagga 4620 attcggcgtt gaaattgggc cagtttgttt tgtgtaaagt aagccaagac acatcgacaa 4680 tgagcaccac catcaatgac caccgccatt cacaagaact ttgactgttt gaagttgatc 4740 ctgagactct tgaagtaatg gctgatcctg catcagcatt gtatatatgg tcttaagtgc 4800 ctggcctcct tatccttcag aatatttatt ttacttacaa tcctcaagtt ttaattgatt 4860 ttaaatattt ttcaatacaa cagtttaggt ttaagatgac caatgacaat gaccaccttt 4920 gcagaaagta aactgattga ataaataaat ctccgttttc ttcaatttat ttcagtgtaa 4980 tgaaaaagtt gcttagtatt tatgaggaaa ttcttcttcc tggcaggtag cttaaagagt 5040 ggggtatata gagccacaac acatgtttat tttgcttggc tgcagttgaa aaatagaaat 5100 tagtgccctt ttgtgacctc tcattccaag attgtcaatt aaaaatgagt ttaaaatgtt 5160 taacttgtga tcgagaccta catgcatgtc ttgatattgt gtaactataa tagagactct 5220 ttaaggagaa tcttaaaaaa aaaaaaacgt ttctcactgt cttaaataga atttttaaat 5280 agtatatatt cagtggcatt ttggagaaca aagtgaattt acttcgactt cttaaatttt 5340 tgtaaaagac tataagttta gacatctttc tcattcaaat ttaaagatat ctttctcctc 5400 ttgatcaatc tatcaatatt gatagaagtc acactagtat ataccattta atacatttac 5460 actttcttat ttaagaagat attgaatgca aaataattga catatagaac tttacaaaca 5520 tatgtccaag gactctaaat tgagactctt ccacatgtac aatctcatca tcctgaagcc 5580 tataatgaag aaaaagatct agaaactgag ttgtggagct gactctaatc aaatgtgatg 5640 attggaatta gaccatttgg cctttgaact ttcataggaa aaatgaccca acatttctta 5700 gcatgagcta cctcatctct agaagctggg atggacttac tattcttgtt tatattttag 5760 atactgaaag gtgctatgct tctgttatta ttccaagact ggagataggc agggctaaaa 5820 aggtattatt atttttcctt taatgatggt gctaaaattc ttcctataaa attccttaaa 5880 aataaagatg gtttaatcac taccattgtg aaaacataac tgttagactt cccgtttctg 5940 aaagaaagag catcgttcca atgcttgttc actgttcctc tgtcatactg tatctggaat 6000 gctttgtaat acttgcatgc ttcttagacc agaacatgta ggtccccttg tgtctcaata 6060 cttttttttt cttaattgca tttgttggct ctattttaat ttttttcttt taaaataaac 6120 agctgggacc atcccaaaag acaagccatg catacaactt tggtcatgta tctctgcaaa 6180 gcatcaaatt aaatgcacgc ttttgtcatg tcagtggttt ttgttttgtg aaattccttt 6240 gaccatatta gatctatttc atttccaata gtgaaaagga gatgtggtgg tatactttgt 6300 ttgccatttg tttaaaagat acaacggata ccttctatca tgtatgtact ggcttataaa 6360 tgaaaatcta tctacaacat tacccacaaa ggcaacatga caccaattat cactgcctct 6420 gcccttaaaa atgtcagagt agtattattg ataaaaaggg caagcaatag atttttcatg 6480 actgaataaa ctgtaataat aaaacatatg tctcaaagtg tatcacatat gaatttagcc 6540 taattgtttt cagtttcatt ctcaatattt agtttacaac atcattttcc cctaaactgg 6600 ttatattttg acctgtatat cttaaatttg agtatttata tgcctaaata catgtgtgag 6660 ttttgtttga cttccaagtc caaactataa gattatataa gttcatatag atgaatcaga 6720 aatatgtggt aatactatta agtcacaaac actaacaatt tccaactata gaaataacag 6780 ttcttatttg gattttggga atgctaccaa taaaagcctg cccagacca 6829 <210> 195 <211> 1769 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1769) <223> CSF3 mRNA <400> 195 agtcgtggcc ccaggtaatt tcctcccagg cctccatggg gttatgtata aaggcccccc 60 tagagctggg ccccaaaaca gcccggagcc tgcagcccag ccccacccag acccatggct 120 ggacctgcca cccagagccc catgaagctg atgggtgagt gtcttggccc aggatgggag 180 agccgcctgc cctggcatgg gagggaggct ggtgtgacag aggggctggg gatccccgtt 240 ctgggaatgg ggattaaagg cacccagtgt ccccgagagg gcctcaggtg gtagggaaca 300 gcatgtctcc tgagcccgct ctgtccccag ccctgcagct gctgctgtgg cacagtgcac 360 tctggacagt gcaggaagcc acccccctgg gccctgccag ctccctgccc cagagcttcc 420 tgctcaagtg cttagagcaa gtgaggaaga tccagggcga tggcgcagcg ctccaggaga 480 agctgtgtgc cacctacaag ctgtgccacc ccgaggagct ggtgctgctc ggacactctc 540 tgggcatccc ctgggctccc ctgagcagct gccccagcca ggccctgcag ctggcaggct 600 gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag gccctggaag 660 ggatctcccc cgagttgggt cccaccttgg acacactgca gctggacgtc gccgactttg 720 ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg cagcccaccc 780 agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg gtcctggttg 840 cctcccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac cttgcccagc 900 cctgagccaa gccctcccca tcccatgtat ttatctctat ttaatattta tgtctattta 960 agcctcatat ttaaagacag ggaagagcag aacggagccc caggcctctg tgtccttccc 1020 tgcatttctg agtttcattc tcctgcctgt agcagtgaga aaaagctcct gtcctcccat 1080 cccctggact gggaggtaga taggtaaata ccaagtattt attactatga ctgctcccca 1140 gccctggctc tgcaatgggc actgggatga gccgctgtga gcccctggtc ctgagggtcc 1200 ccacctggga cccttgagag tatcaggtct cccacgtggg agacaagaaa tccctgttta 1260 atatttaaac agcagtgttc cccatctggg tccttgcacc cctcactctg gcctcagccg 1320 actgcacagc ggcccctgca tccccttggc tgtgaggccc ctggacaagc agaggtggcc 1380 agagctggga ggcatggccc tggggtccca cgaatttgct ggggaatctc gtttttcttc 1440 ttaagacttt tgggacatgg tttgactccc gaacatcacc gacgcgtctc ctgtttttct 1500 gggtggcctc gggacacctg ccctgccccc acgagggtca ggactgtgac tctttttagg 1560 gccaggcagg tgcctggaca tttgccttgc tggacgggga ctggggatgt gggagggagc 1620 agacaggagg aatcatgtca ggcctgtgtg tgaaaggaag ctccactgtc accctccacc 1680 tcttcacccc ccactcacca gtgtcccctc cactgtcaca ttgtaactga acttcaggat 1740 aataaagtgt ttgcctccaa aaaaaaaaa 1769 <210> 196 <211> 2358 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2358) <223> CTCF mRNA <400> 196 aaactcacac aacaactctt ccccgctgag aggagacagc cagtgcgact ccaccctcca 60 gctcgacggc agccgccccg gccgacagcc ccgagacgac agcccggcgc gtcccggtcc 120 ccacctccga ccaccgccag cgctccaggc cccgccgctc cccgctcgcc gccaccgcgc 180 cctccgctcc gcccgcagtg ccaaccatga ccgccgccag tatgggcccc gtccgcgtcg 240 ccttcgtggt cctcctcgcc ctctgcagcc ggccggccgt cggccagaac tgcagcgggc 300 cgtgccggtg cccggacgag ccggcgccgc gctgcccggc gggcgtgagc ctcgtgctgg 360 acggctgcgg ctgctgccgc gtctgcgcca agcagctggg cgagctgtgc accgagcgcg 420 acccctgcga cccgcacaag ggcctcttct gtgacttcgg ctccccggcc aaccgcaaga 480 tcggcgtgtg caccgccaaa gatggtgctc cctgcatctt cggtggtacg gtgtaccgca 540 gcggagagtc cttccagagc agctgcaagt accagtgcac gtgcctggac ggggcggtgg 600 gctgcatgcc cctgtgcagc atggacgttc gtctgcccag ccctgactgc cccttcccga 660 ggagggtcaa gctgcccggg aaatgctgcg aggagtgggt gtgtgacgag cccaaggacc 720 aaaccgtggt tgggcctgcc ctcgcggctt accgactgga agacacgttt ggcccagacc 780 caactatgat tagagccaac tgcctggtcc agaccacaga gtggagcgcc tgttccaaga 840 cctgtgggat gggcatctcc acccgggtta ccaatgacaa cgcctcctgc aggctagaga 900 agcagagccg cctgtgcatg gtcaggcctt gcgaagctga cctggaagag aacattaaga 960 agggcaaaaa gtgcatccgt actcccaaaa tctccaagcc tatcaagttt gagctttctg 1020 gctgcaccag catgaagaca taccgagcta aattctgtgg agtatgtacc gacggccgat 1080 gctgcacccc ccacagaacc accaccctgc cggtggagtt caagtgccct gacggcgagg 1140 tcatgaagaa gaacatgatg ttcatcaaga cctgtgcctg ccattacaac tgtcccggag 1200 acaatgacat ctttgaatcg ctgtactaca ggaagatgta cggagacatg gcatgaagcc 1260 agagagtgag agacattaac tcattagact ggaacttgaa ctgattcaca tctcattttt 1320 ccgtaaaaat gatttcagta gcacaagtta tttaaatctg tttttctaac tgggggaaaa 1380 gattcccacc caattcaaaa cattgtgcca tgtcaaacaa atagtctatc aaccccagac 1440 actggtttga agaatgttaa gacttgacag tggaactaca ttagtacaca gcaccagaat 1500 gtatattaag gtgtggcttt aggagcagtg ggagggtacc agcagaaagg ttagtatcat 1560 cagatagcat cttatacgag taatatgcct gctatttgaa gtgtaattga gaaggaaaat 1620 tttagcgtgc tcactgacct gcctgtagcc ccagtgacag ctaggatgtg cattctccag 1680 ccatcaagag actgagtcaa gttgttcctt aagtcagaac agcagactca gctctgacat 1740 tctgattcga atgacactgt tcaggaatcg gaatcctgtc gattagactg gacagcttgt 1800 ggcaagtgaa tttgcctgta acaagccaga ttttttaaaa tttatattgt aaatattgtg 1860 tgtgtgtgtg tgtgtgtata tatatatata tgtacagtta tctaagttaa tttaaagttg 1920 tttgtgcctt tttatttttg tttttaatgc tttgatattt caatgttagc ctcaatttct 1980 gaacaccata ggtagaatgt aaagcttgtc tgatcgttca aagcatgaaa tggatactta 2040 tatggaaatt ctgctcagat agaatgacag tccgtcaaaa cagattgttt gcaaagggga 2100 ggcatcagtg tccttggcag gctgatttct aggtaggaaa tgtggtagcc tcacttttaa 2160 tgaacaaatg gcctttatta aaaactgagt gactctatat agctgatcag ttttttcacc 2220 tggaagcatt tgtttctact ttgatatgac tgtttttcgg acagtttatt tgttgagagt 2280 gtgaccaaaa gttacatgtt tgcacctttc tagttgaaaa taaagtgtat attttttcta 2340 taaaaaaaaa aaaaaaaa 2358 <210> 197 <211> 3661 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3661) <223> CTNNB1 mRNA <400> 197 aagcctctcg gtctgtggca gcagcgttgg cccggccccg ggagcggaga gcgaggggag 60 gcggagacgg aggaaggtct gaggagcagc ttcagtcccc gccgagccgc caccgcaggt 120 cgaggacggt cggactcccg cggcgggagg agcctgttcc cctgagggta tttgaagtat 180 accatacaac tgttttgaaa atccagcgtg gacaatggct actcaagctg atttgatgga 240 gttggacatg gccatggaac cagacagaaa agcggctgtt agtcactggc agcaacagtc 300 ttacctggac tctggaatcc attctggtgc cactaccaca gctccttctc tgagtggtaa 360 aggcaatcct gaggaagagg atgtggatac ctcccaagtc ctgtatgagt gggaacaggg 420 attttctcag tccttcactc aagaacaagt agctgatatt gatggacagt atgcaatgac 480 tcgagctcag agggtacgag ctgctatgtt ccctgagaca ttagatgagg gcatgcagat 540 cccatctaca cagtttgatg ctgctcatcc cactaatgtc cagcgtttgg ctgaaccatc 600 acagatgctg aaacatgcag ttgtaaactt gattaactat caagatgatg cagaacttgc 660 cacacgtgca atccctgaac tgacaaaact gctaaatgac gaggaccagg tggtggttaa 720 taaggctgca gttatggtcc atcagctttc taaaaaggaa gcttccagac acgctatcat 780 gcgttctcct cagatggtgt ctgctattgt acgtaccatg cagaatacaa atgatgtaga 840 aacagctcgt tgtaccgctg ggaccttgca taacctttcc catcatcgtg agggcttact 900 ggccatcttt aagtctggag gcattcctgc cctggtgaaa atgcttggtt caccagtgga 960 ttctgtgttg ttttatgcca ttacaactct ccacaacctt ttattacatc aagaaggagc 1020 taaaatggca gtgcgtttag ctggtgggct gcagaaaatg gttgccttgc tcaacaaaac 1080 aaatgttaaa ttcttggcta ttacgacaga ctgccttcaa attttagctt atggcaacca 1140 agaaagcaag ctcatcatac tggctagtgg tggaccccaa gctttagtaa atataatgag 1200 gacctatact tacgaaaaac tactgtggac cacaagcaga gtgctgaagg tgctatctgt 1260 ctgctctagt aataagccgg ctattgtaga agctggtgga atgcaagctt taggacttca 1320 cctgacagat ccaagtcaac gtcttgttca gaactgtctt tggactctca ggaatctttc 1380 agatgctgca actaaacagg aagggatgga aggtctcctt gggactcttg ttcagcttct 1440 gggttcagat gatataaatg tggtcacctg tgcagctgga attctttcta acctcacttg 1500 caataattat aagaacaaga tgatggtctg ccaagtgggt ggtatagagg ctcttgtgcg 1560 tactgtcctt cgggctggtg acagggaaga catcactgag cctgccatct gtgctcttcg 1620 tcatctgacc agccgacacc aagaagcaga gatggcccag aatgcagttc gccttcacta 1680 tggactacca gttgtggtta agctcttaca cccaccatcc cactggcctc tgataaaggc 1740 tactgttgga ttgattcgaa atcttgccct ttgtcccgca aatcatgcac ctttgcgtga 1800 gcagggtgcc attccacgac tagttcagtt gcttgttcgt gcacatcagg atacccagcg 1860 ccgtacgtcc atgggtggga cacagcagca atttgtggag ggggtccgca tggaagaaat 1920 agttgaaggt tgtaccggag cccttcacat cctagctcgg gatgttcaca accgaattgt 1980 tatcagagga ctaaatacca ttccattgtt tgtgcagctg ctttattctc ccattgaaaa 2040 catccaaaga gtagctgcag gggtcctctg tgaacttgct caggacaagg aagctgcaga 2100 agctattgaa gctgagggag ccacagctcc tctgacagag ttacttcact ctaggaatga 2160 aggtgtggcg acatatgcag ctgctgtttt gttccgaatg tctgaggaca agccacaaga 2220 ttacaagaaa cggctttcag ttgagctgac cagctctctc ttcagaacag agccaatggc 2280 ttggaatgag actgctgatc ttggacttga tattggtgcc cagggagaac cccttggata 2340 tcgccaggat gatcctagct atcgttcttt tcactctggt ggatatggcc aggatgcctt 2400 gggtatggac cccatgatgg aacatgagat gggtggccac caccctggtg ctgactatcc 2460 agttgatggg ctgccagatc tggggcatgc ccaggacctc atggatgggc tgcctccagg 2520 tgacagcaat cagctggcct ggtttgatac tgacctgtaa atcatccttt aggtaagaag 2580 ttttaaaaag ccagtttggg taaaatactt ttactctgcc tacagaactt cagaaagact 2640 tggttggtag ggtgggagtg gtttaggcta tttgtaaatc tgccacaaaa acaggtatat 2700 actttgaaag gagatgtctt ggaacattgg aatgttctca gatttctggt tgttatgtga 2760 tcatgtgtgg aagttattaa ctttaatgtt ttttgccaca gcttttgcaa cttaatactc 2820 aaatgagtaa catttgctgt tttaaacatt aatagcagcc tttctctctt tatacagctg 2880 tattgtctga acttgcattg tgattggcct gtagagttgc tgagagggct cgaggggtgg 2940 gctggtatct cagaaagtgc ctgacacact aaccaagctg agtttcctat gggaacaatt 3000 gaagtaaact ttttgttctg gtcctttttg gtcgaggagt aacaatacaa atggattttg 3060 ggagtgactc aagaagtgaa gaatgcacaa gaatggatca caagatggaa tttatcaaac 3120 cctagccttg cttgttaaat tttttttttt ttttttttaa gaatatctgt aatggtactg 3180 actttgcttg ctttgaagta gctctttttt tttttttttt tttttttttg cagtaactgt 3240 tttttaagtc tctcgtagtg ttaagttata gtgaatactg ctacagcaat ttctaatttt 3300 taagaattga gtaatggtgt agaacactaa ttcataatca ctctaattaa ttgtaatctg 3360 aataaagtgt aacaattgtg tagccttttt gtataaaata gacaaataga aaatggtcca 3420 attagtttcc tttttaatat gcttaaaata agcaggtgga tctatttcat gtttttgatc 3480 aaaaactatt tgggatatgt atgggtaggg taaatcagta agaggtgtta tttggaacct 3540 tgttttggac agtttaccag ttgcctttta tcccaaagtt gttgtaacct gctgtgatac 3600 gatgcttcaa gagaaaatgc ggttataaaa aatggttcag aattaaactt ttaattcatt 3660 c 3661 <210> 198 <211> 1629 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1629) <223> CTSK mRNA <400> 198 acactttgct gccgaaacga agccagacaa cagatttcca tcagcaggat gtgggggctc 60 aaggttctgc tgctacctgt ggtgagcttt gctctgtacc ctgaggagat actggacacc 120 cactgggagc tatggaagaa gacccacagg aagcaatata acaacaaggt ggatgaaatc 180 tctcggcgtt taatttggga aaaaaacctg aagtatattt ccatccataa ccttgaggct 240 tctcttggtg tccatacata tgaactggct atgaaccacc tgggggacat gaccagtgaa 300 gaggtggttc agaagatgac tggactcaaa gtacccctgt ctcattcccg cagtaatgac 360 accctttata tcccagaatg ggaaggtaga gccccagact ctgtcgacta tcgaaagaaa 420 ggatatgtta ctcctgtcaa aaatcagggt cagtgtggtt cctgttgggc ttttagctct 480 gtgggtgccc tggagggcca actcaagaag aaaactggca aactcttaaa tctgagtccc 540 cagaacctag tggattgtgt gtctgagaat gatggctgtg gagggggcta catgaccaat 600 gccttccaat atgtgcagaa gaaccggggt attgactctg aagatgccta cccatatgtg 660 ggacaggaag agagttgtat gtacaaccca acaggcaagg cagctaaatg cagagggtac 720 agagagatcc ccgaggggaa tgagaaagcc ctgaagaggg cagtggcccg agtgggacct 780 gtctctgtgg ccattgatgc aagcctgacc tccttccagt tttacagcaa aggtgtgtat 840 tatgatgaaa gctgcaatag cgataatctg aaccatgcag ttttggcagt gggatatgga 900 atccagaagg gaaacaagca ctggataatt aaaaacagct ggggagaaaa ctggggaaac 960 aaaggatata tcctcatggc tcgaaataag aacaacgcct gtggcattgc caacctggcc 1020 agcttcccca agatgtgact ccagccagcc aaatccatcc tgctcttcca tttcttccac 1080 gatggtgcag tgtaacgatg cactttggaa gggagttggt gtgctatttt tgaagcagat 1140 gtggtgatac tgagattgtc tgttcagttt ccccatttgt ttgtgcttca aatgatcctt 1200 cctactttgc ttctctccac ccatgacctt tttcactgtg gccatcagga ctttccctga 1260 cagctgtgta ctcttaggct aagagatgtg actacagcct gcccctgact gtgttgtccc 1320 agggctgatg ctgtacaggt acaggctgga gattttcaca taggttagat tctcattcac 1380 gggactagtt agctttaagc accctagagg actagggtaa tctgacttct cacttcctaa 1440 gttcccttct atatcctcaa ggtagaaatg tctatgtttt ctactccaat tcataaatct 1500 attcataagt ctttggtaca agtttacatg ataaaaagaa atgtgatttg tcttcccttc 1560 tttgcacttt tgaaataaag tatttatctc ctgtctacag tttaataaat agcatctagt 1620 acacattca 1629 <210> 199 <211> 1184 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1184) <223> CXCL1 mRNA <400> 199 cacagagccc gggccgcagg cacctcctcg ccagctcttc cgctcctctc acagccgcca 60 gacccgcctg ctgagcccca tggcccgcgc tgctctctcc gccgccccca gcaatccccg 120 gctcctgcga gtggcactgc tgctcctgct cctggtagcc gctggccggc gcgcagcagg 180 agcgtccgtg gccactgaac tgcgctgcca gtgcttgcag accctgcagg gaattcaccc 240 caagaacatc caaagtgtga acgtgaagtc ccccggaccc cactgcgccc aaaccgaagt 300 catagccaca ctcaagaatg ggcggaaagc ttgcctcaat cctgcatccc ccatagttaa 360 gaaaatcatc gaaaagatgc tgaacagtga caaatccaac tgaccagaag ggaggaggaa 420 gctcactggt ggctgttcct gaaggaggcc ctgcccttat aggaacagaa gaggaaagag 480 agacacagct gcagaggcca cctggattgt gcctaatgtg tttgagcatc gcttaggaga 540 agtcttctat ttatttattt attcattagt tttgaagatt ctatgttaat attttaggtg 600 taaaataatt aagggtatga ttaactctac ctgcacactg tcctattata ttcattcttt 660 ttgaaatgtc aaccccaagt tagttcaatc tggattcata tttaatttga aggtagaatg 720 ttttcaaatg ttctccagtc attatgttaa tatttctgag gagcctgcaa catgccagcc 780 actgtgatag aggctggcgg atccaagcaa atggccaatg agatcattgt gaaggcaggg 840 gaatgtatgt gcacatctgt tttgtaactg tttagatgaa tgtcagttgt tatttattga 900 aatgatttca cagtgtgtgg tcaacatttc tcatgttgaa actttaagaa ctaaaatgtt 960 ctaaatatcc cttggacatt ttatgtcttt cttgtaaggc atactgcctt gtttaatggt 1020 agttttacag tgtttctggc ttagaacaaa ggggcttaat tattgatgtt ttcatagaga 1080 atataaaaat aaagcactta tagaaaaaac tcgtttgatt tttgggggga aacaagggct 1140 acctttactg gaaaatctgg tgatttataa aaaaaaaaaa aaaa 1184 <210> 200 <211> 2436 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2436) <223> CXCL5 mRNA <400> 200 acagtgctcc ggatcctcca atcttcgctc ctccaatctc cgctcctcca cccagttcag 60 gaacccgcga ccgctcgcag cgctctcttg accactatga gcctcctgtc cagccgcgcg 120 gcccgtgtcc ccggtccttc gagctccttg tgcgcgctgt tggtgctgct gctgctgctg 180 acgcagccag ggcccatcgc cagcgctggt cctgccgctg ctgtgttgag agagctgcgt 240 tgcgtttgtt tacagaccac gcaaggagtt catcccaaaa tgatcagtaa tctgcaagtg 300 ttcgccatag gcccacagtg ctccaaggtg gaagtggtag cctccctgaa gaacgggaag 360 gaaatttgtc ttgatccaga agcccctttt ctaaagaaag tcatccagaa aattttggac 420 ggtggaaaca aggaaaactg attaagagaa atgagcacgc atggaaaagt ttcccagtct 480 tcagcagaga agttttctgg aggtctctga acccagggaa gacaagaagg aaagattttg 540 ttgttgtttg tttatttgtt tttccagtag ttagctttct tcctggattc ctcactttga 600 agagtgtgag gaaaacctat gtttgccgct taagctttca gctcagctaa tgaagtgttt 660 agcatagtac ctctgctatt tgctgttatt ttatctgcta tgctattgaa gttttggcaa 720 ttgactatag tgtgagccag gaatcactgg ctgttaatct ttcaaagtgt cttgaattgt 780 aggtgactat tatatttcca agaaatattc cttaagatat taactgagaa ggctgtggat 840 ttaatgtgga aatgatgttt cataagaatt ctgttgatgg aaatacactg ttatcttcac 900 ttttataaga aataggaaat attttaatgt ttcttgggga atatgttaga gaatttcctt 960 actcttgatt gtgggatact atttaattat ttcactttag aaagctgagt gtttcacacc 1020 ttatctatgt agaatatatt tccttattca gaatttctaa aagtttaagt tctatgaggg 1080 ctaatatctt atcttcctat aattttagac attctttatc tttttagtat ggcaaactgc 1140 catcatttac ttttaaactt tgattttata tgctatttat taagtatttt attaggagta 1200 ccataattct ggtagctaaa tatatatttt agatagatga agaagctaga aaacaggcaa 1260 attcctgact gctagtttat atagaaatgt attcttttag tttttaaagt aaaggcaaac 1320 ttaacaatga cttgtactct gaaagttttg gaaacgtatt caaacaattt gaatataaat 1380 ttatcattta gttataaaaa tatatagcga catcctcgag gccctagcat ttctccttgg 1440 ataggggacc agagagagct tggaatgtta aaaacaaaac aaaacaaaaa aaaacaagga 1500 gaagttgtcc aagggatgtc aattttttat ccctctgtat gggttagatt ttccaaaatc 1560 ataatttgaa gaaggccagc atttatggta gaatatataa ttatatataa ggtggccacg 1620 ctggggcaag ttccctcccc actcacagct ttggcccctt tcacagagta gaacctgggt 1680 tagaggattg cagaagacga gcgggagcgg ggagggcagg gaagatgcct gtcgggtttt 1740 tagcacagtt catttcactg ggattttgaa gcatttctgt ctgaatgtaa agcctgttct 1800 agtcctggtg ggacacactg gggttggggg tgggggaaga tgcggtaatg aaaccggtta 1860 gtcagtgttg tcttaatatc cttgataatg ctgtaaagtt tatttttaca aatatttctg 1920 tttaagctat ttcacctttg tttggaaatc cttccctttt aaagagaaaa tgtgacactt 1980 gtgaaaaggc ttgtaggaaa gctcctccct ttttttcttt aaacctttaa atgacaaacc 2040 taggtaatta atggttgtga atttctattt ttgctttgtt tttaatgaac atttgtcttt 2100 cagaatagga ttctgtgata atatttaaat ggcaaaaaca aaacataatt ttgtgcaatt 2160 aacaaagcta ctgcaagaaa aataaaacat ttcttggtaa aaacgtatgt atttatatat 2220 tatatattta tatataatat atattatata tttagcattg ctgagctttt tagatgccta 2280 ttgtgtatct tttaaaggtt ttgaccattt tgttatgagt aattacatat atattacatt 2340 cactatatta aaattgtact tttttactat gtgtctcatt ggttcatagt ctttattttg 2400 tcctttgaat aaacattaaa agatttctaa acttca 2436 <210> 201 <211> 1537 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1537) <223> CXCL6 mRNA <400> 201 caaagtgctc tgtatcctcc agtctccgcg cctccaccca gctcaggaac ccgcgaaccc 60 tctcttgacc actatgagcc tcccgtccag ccgcgcggcc cgtgtcccgg gtccttcggg 120 ctccttgtgc gcgctgctcg cgctgctgct cctgctgacg ccgccggggc ccctcgccag 180 cgctggtcct gtctctgctg tgctgacaga gctgcgttgc acttgtttac gcgttacgct 240 gagagtaaac cccaaaacga ttggtaaact gcaggtgttc cccgcaggcc cgcagtgctc 300 caaggtggaa gtggtagcct ccctgaagaa cgggaagcaa gtttgtctgg acccggaagc 360 cccttttcta aagaaagtca tccagaaaat tttggacagt ggaaacaaga aaaactgagt 420 aacaaaaaag accatgcatc ataaaattgc ccagtcttca gcggagcagt tttctggaga 480 tccctggacc cagtaagaat aagaaggaag ggttggtttt tttccatttt ctacatggat 540 tccctacttt gaagagtgtg ggggaaagcc tacgcttctc cctgaagttt acagctcagc 600 taatgaagta ctaatatagt atttccacta tttactgtta ttttacctga taagttattg 660 aaccctttgg caattgacca tattgtgagc aaagaatcac tggttattag tctttcaatg 720 aatattgaat tgaagataac tattgtattt ctatcataca ttccttaaag tcttaccgaa 780 aaggctgtgg atttcgtatg gaaataatgt tttattagtg tgctgttgag ggaggtatcc 840 tgttgttctt actcactctt ctcataaaat aggaaatatt ttagttctgt ttcttgggga 900 atatgttact ctttacccta ggatgctatt taagttgtac tgtattagaa cactgggtgt 960 gtcataccgt tatctgtgca gaatatattt ccttattcag aatttctaaa aatttaagtt 1020 ctgtaagggc taatatattc tcttcctatg gttttagacg tttgatgtct tcttagtatg 1080 gcataatgtc atgatttact cattaaactt tgattttgta tgctattttt tcactatagg 1140 atgactataa ttctggtcac taaatataca ctttagatag atgaagaagc ccaaaaacag 1200 ataaattcct gattgctaat ttacatagaa atgtattctc ttggtttttt aaataaaagc 1260 aaaattaaca atgatctgtg ctctgaaagt tttgaaaata tatttgaaca atttgaatat 1320 aaattcatca tttagtcctc aaaatatata tagcattgct aagattttca gatatctatt 1380 gtggatcttt taaaggtttt gaccattttg ttatgaggaa ttatacatgt atcacattca 1440 ctatattaaa attgcacttt tattttttcc tgtgtgtcat gttggttttt ggtacttgta 1500 ttgtcatttg gagaaacaat aaaagatttc taaacca 1537 <210> 202 <211> 3395 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3395) <223> DUSP6 mRNA <400> 202 agggcttttg tgcatgctaa ttgcgccatt ggtgcgcaaa agttccgacg cgaagtgtga 60 actctcaaca gaaggaaaca tgagacaact gaagtgccct ggtttatgtg ccctgctcct 120 cctccgctgc cgcctcccct tctttctcct tcctcccgcc gagcccgctg ttgcagcttg 180 tttgcactgg ggcttatccg gagcggaaat tcctttccgt ttttgtgaat gacaaactca 240 ttaacaattc atcaacacaa cctgttccag ccggcccgtc cccacggcaa cagccccttc 300 cgcagcacgc tcattggctg gcccggagaa tgtatccatt gagacgctcg ctgtttgtat 360 ccattgagga gctgcctcgc gcagggggtg tgcgaggctg agtccaagag atagcaaatc 420 gagtcttaaa taatccgggg agaaagacgc ccgggtagat ttgaggtgca gccttggagg 480 gagggattag aagccgctag actttttttc ctcccctctc agtagcacgg agtccgaatt 540 aattggattt cattcactgg ggaggaacaa aaactatctg ggcagcttca ttgagagaga 600 ttcattgaca ctaagagcca gcggctgcag ctgggtgcag agagaacctc cggctttact 660 tctgtctcgt ctgccccaac cgctagcctc ggcttgggta aggcgaggcg gaattaaacc 720 ccgctccgag agcggcagct tcgcgcgcgg tgcgctcggc ctatgcctgc cccgaggggc 780 gtctggtagg caccccgccc tctcccgcag ctcgaccccc atgatagata cgctcagacc 840 cgtgcccttc gcgtcggaaa tggcgatcag caagacggtg gcgtggctca acgagcagct 900 ggagctgggc aacgagcggc tgctgctgat ggactgccgg ccgcaggagc tatacgagtc 960 gtcgcacatc gagtcggcca tcaacgtggc catcccgggc atcatgctgc ggcgcctgca 1020 gaagggtaac ctgccggtgc gcgcgctctt cacgcgcggc gaggaccggg accgcttcac 1080 ccggcgctgt ggcaccgaca cagtggtgct ctacgacgag agcagcagcg actggaacga 1140 gaatacgggc ggcgagtcgg tgctcgggct gctgctcaag aagctcaagg acgagggctg 1200 ccgggcgttc tacctggaag gtggcttcag taagttccaa gccgagttct ccctgcattg 1260 cgagaccaat ctagacggct cgtgtagcag cagctcgccg ccgttgccag tgctggggct 1320 cgggggcctg cggatcagct ctgactcttc ctcggacatc gagtctgacc ttgaccgaga 1380 ccccaatagt gcaacagact cggatggtag tccgctgtcc aacagccagc cttccttccc 1440 agtggagatc ttgcccttcc tctacttggg ctgtgccaaa gactccacca acttggacgt 1500 gttggaggaa ttcggcatca agtacatctt gaacgtcacc cccaatttgc cgaatctctt 1560 tgagaacgca ggagagttta aatacaagca aatccccatc tcggatcact ggagccaaaa 1620 cctgtcccag tttttccctg aggccatttc tttcatagat gaagcccggg gcaagaactg 1680 tggtgtcttg gtacattgct tggctggcat tagccgctca gtcactgtga ctgtggctta 1740 ccttatgcag aagctcaatc tgtcgatgaa cgatgcctat gacattgtca aaatgaaaaa 1800 atccaacata tcccctaact tcaacttcat gggtcagctg ctggacttcg agaggacgct 1860 gggactcagc agcccatgtg acaacagggt tccagcacag cagctgtatt ttaccacccc 1920 ttccaaccag aatgtatacc aggtggactc tctgcaatct acgtgaaaga ccccacaccc 1980 ctccttgctg gaatgtgtct ggcccttcag cagtttctct tggcagcatc agctgggctg 2040 ctttctttgt gtgtggcccc aggtgtcaaa atgacaccag ctgtctgtac tagacaaggt 2100 taccaagtgc ggaattggtt aatactaaca gagagatttg ctccattctc tttggaataa 2160 caggacatgc tgtatagata caggcagtag gtttgctctg tacccatgtg tacagcctac 2220 ccatgcaggg actgggattc gaggacttcc aggcgcatag ggtagaacca aatgataggg 2280 taggagcatg tgttctttag ggccttgtaa ggctgtttcc ttttgcatct ggaactgact 2340 atataattgt cttcaatgaa gactaattca attttgcata tagaggagcc aaagagagat 2400 ttcagctctg tatttgtggt atcagtttgg aaaaaaaaat ctgatactcc atttgattat 2460 tgtaaatatt tgatcttgaa tcacttgaca gtgtttgttt gaattgtgtt tgttttttcc 2520 tttgatgggc ttaaaagaaa ttatccaaag ggagaaagag cagtatgcca cttcttaaaa 2580 cagaacaaaa caaaaaaaga aaattgtgct cttttctaat ccaaagggta tatttgcagc 2640 atgcttgact ttaccaattc tgatgacatc tttacggaca ctattatcac taagaccttg 2700 ttatggcgaa gtctttagtc tttttcatgt attttcctca tgattttttc tctttatgta 2760 gtttgactat gccttacctt tgtaaatatt tttgcttgtg ttgtcgcaaa ggggataatc 2820 tgggaaagac accaaatcat gggctcactt taaaaaaaga aagaataaaa aaaccttcag 2880 ctgtgctaaa cagtatatta cctctgtata aaattcttca gggagtgtca cctcaaatgc 2940 aatactttgg gttggtttct ttcctttaaa aaaatttgta taaaactgga agtgtgtgtg 3000 tgtgagcatg ggtacccatt tgataagaga aatgcatttg attgtgaaga agggagagtt 3060 aaattctcca ttatgttcgt ggtgtaaagt ttagagctgg aatttattat aagaatgtaa 3120 aaccttaaat tattaataaa taactatttt ggctattgaa tgtgtgtttt taaaaactca 3180 gttataccta tgtgtgaagt gacacatttt agaacttttt cattcaggga ttgattttga 3240 cttgtaggca tagtagggca aggttctttt aagcttttcc tagaacgttt ttcagcagca 3300 gtttatgaaa ttcatcgttt gccacgaata aagatgacat cctagaatgg accgactgta 3360 ccgtgtatat gaacaatacc tcttatgagt atagt 3395 <210> 203 <211> 6369 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6369) <223> EGFR mRNA <400> 203 gtccgggcag cccccggcgc agcgcggccg cagcagcctc cgccccccgc acggtgtgag 60 cgcccgacgc ggccgaggcg gccggagtcc cgagctagcc ccggcggccg ccgccgccca 120 gaccggacga caggccacct cgtcggcgtc cgcccgagtc cccgcctcgc cgccaacgcc 180 acaaccaccg cgcacggccc cctgactccg tccagtattg atcgggagag ccggagcgag 240 ctcttcgggg agcagcgatg cgaccctccg ggacggccgg ggcagcgctc ctggcgctgc 300 tggctgcgct ctgcccggcg agtcgggctc tggaggaaaa gaaagtttgc caaggcacga 360 gtaacaagct cacgcagttg ggcacttttg aagatcattt tctcagcctc cagaggatgt 420 tcaataactg tgaggtggtc cttgggaatt tggaaattac ctatgtgcag aggaattatg 480 atctttcctt cttaaagacc atccaggagg tggctggtta tgtcctcatt gccctcaaca 540 cagtggagcg aattcctttg gaaaacctgc agatcatcag aggaaatatg tactacgaaa 600 attcctatgc cttagcagtc ttatctaact atgatgcaaa taaaaccgga ctgaaggagc 660 tgcccatgag aaatttacag gaaatcctgc atggcgccgt gcggttcagc aacaaccctg 720 ccctgtgcaa cgtggagagc atccagtggc gggacatagt cagcagtgac tttctcagca 780 acatgtcgat ggacttccag aaccacctgg gcagctgcca aaagtgtgat ccaagctgtc 840 ccaatgggag ctgctggggt gcaggagagg agaactgcca gaaactgacc aaaatcatct 900 gtgcccagca gtgctccggg cgctgccgtg gcaagtcccc cagtgactgc tgccacaacc 960 agtgtgctgc aggctgcaca ggcccccggg agagcgactg cctggtctgc cgcaaattcc 1020 gagacgaagc cacgtgcaag gacacctgcc ccccactcat gctctacaac cccaccacgt 1080 accagatgga tgtgaacccc gagggcaaat acagctttgg tgccacctgc gtgaagaagt 1140 gtccccgtaa ttatgtggtg acagatcacg gctcgtgcgt ccgagcctgt ggggccgaca 1200 gctatgagat ggaggaagac ggcgtccgca agtgtaagaa gtgcgaaggg ccttgccgca 1260 aagtgtgtaa cggaataggt attggtgaat ttaaagactc actctccata aatgctacga 1320 atattaaaca cttcaaaaac tgcacctcca tcagtggcga tctccacatc ctgccggtgg 1380 catttagggg tgactccttc acacatactc ctcctctgga tccacaggaa ctggatattc 1440 tgaaaaccgt aaaggaaatc acagggtttt tgctgattca ggcttggcct gaaaacagga 1500 cggacctcca tgcctttgag aacctagaaa tcatacgcgg caggaccaag caacatggtc 1560 agttttctct tgcagtcgtc agcctgaaca taacatcctt gggattacgc tccctcaagg 1620 agataagtga tggagatgtg ataatttcag gaaacaaaaa tttgtgctat gcaaatacaa 1680 taaactggaa aaaactgttt gggacctccg gtcagaaaac caaaattata agcaacagag 1740 gtgaaaacag ctgcaaggcc acaggccagg tctgccatgc cttgtgctcc cccgagggct 1800 gctggggccc ggagcccagg gactgcgtct cttgccggaa tgtcagccga ggcagggaat 1860 gcgtggacaa gtgcaacctt ctggagggtg agccaaggga gtttgtggag aactctgagt 1920 gcatacagtg ccacccagag tgcctgcctc aggccatgaa catcacctgc acaggacggg 1980 gaccagacaa ctgtatccag tgtgcccact acattgacgg cccccactgc gtcaagacct 2040 gcccggcagg agtcatggga gaaaacaaca ccctggtctg gaagtacgca gacgccggcc 2100 atgtgtgcca cctgtgccat ccaaactgca cctacggatg cactgggcca ggtcttgaag 2160 gctgtccaac gaatgggcct aagatcccgt ccatcgccac tgggatggtg ggggccctcc 2220 tcttgctgct ggtggtggcc ctggggatcg gcctcttcat gcgaaggcgc cacatcgttc 2280 ggaagcgcac gctgcggagg ctgctgcagg agagggagct tgtggagcct cttacaccca 2340 gtggagaagc tcccaaccaa gctctcttga ggatcttgaa ggaaactgaa ttcaaaaaga 2400 tcaaagtgct gggctccggt gcgttcggca cggtgtataa gggactctgg atcccagaag 2460 gtgagaaagt taaaattccc gtcgctatca aggaattaag agaagcaaca tctccgaaag 2520 ccaacaagga aatcctcgat gaagcctacg tgatggccag cgtggacaac ccccacgtgt 2580 gccgcctgct gggcatctgc ctcacctcca ccgtgcagct catcacgcag ctcatgccct 2640 tcggctgcct cctggactat gtccgggaac acaaagacaa tattggctcc cagtacctgc 2700 tcaactggtg tgtgcagatc gcaaagggca tgaactactt ggaggaccgt cgcttggtgc 2760 accgcgacct ggcagccagg aacgtactgg tgaaaacacc gcagcatgtc aagatcacag 2820 attttgggct ggccaaactg ctgggtgcgg aagagaaaga ataccatgca gaaggaggca 2880 aagtgcctat caagtggatg gcattggaat caattttaca cagaatctat acccaccaga 2940 gtgatgtctg gagctacggg gtgactgttt gggagttgat gacctttgga tccaagccat 3000 atgacggaat ccctgccagc gagatctcct ccatcctgga gaaaggagaa cgcctccctc 3060 agccacccat atgtaccatc gatgtctaca tgatcatggt caagtgctgg atgatagacg 3120 cagatagtcg cccaaagttc cgtgagttga tcatcgaatt ctccaaaatg gcccgagacc 3180 cccagcgcta ccttgtcatt cagggggatg aaagaatgca tttgccaagt cctacagact 3240 ccaacttcta ccgtgccctg atggatgaag aagacatgga cgacgtggtg gatgccgacg 3300 agtacctcat cccacagcag ggcttcttca gcagcccctc cacgtcacgg actcccctcc 3360 tgagctctct gagtgcaacc agcaacaatt ccaccgtggc ttgcattgat agaaatgggc 3420 tgcaaagctg tcccatcaag gaagacagct tcttgcagcg atacagctca gaccccacag 3480 gcgccttgac tgaggacagc atagacgaca ccttcctccc agtgcctgaa tacataaacc 3540 agtccgttcc caaaaggccc gctggctctg tgcagaatcc tgtctatcac aatcagcctc 3600 tgaaccccgc gcccagcaga gacccacact accaggaccc ccacagcact gcagtgggca 3660 accccgagta tctcaacact gtccagccca cctgtgtcaa cagcacattc gacagccctg 3720 cccactgggc ccagaaaggc agccaccaaa ttagcctgga caaccctgac taccagcagg 3780 acttctttcc caaggaagcc aagccaaatg gcatctttaa gggctccaca gctgaaaatg 3840 cagaatacct aagggtcgcg ccacaaagca gtgaatttat tggagcatga ccacggagga 3900 tagtatgagc cctaaaaatc cagactcttt cgatacccag gaccaagcca cagcaggtcc 3960 tccatcccaa cagccatgcc cgcattagct cttagaccca cagactggtt ttgcaacgtt 4020 tacaccgact agccaggaag tacttccacc tcgggcacat tttgggaagt tgcattcctt 4080 tgtcttcaaa ctgtgaagca tttacagaaa cgcatccagc aagaatattg tccctttgag 4140 cagaaattta tctttcaaag aggtatattt gaaaaaaaaa aaaagtatat gtgaggattt 4200 ttattgattg gggatcttgg agtttttcat tgtcgctatt gatttttact tcaatgggct 4260 cttccaacaa ggaagaagct tgctggtagc acttgctacc ctgagttcat ccaggcccaa 4320 ctgtgagcaa ggagcacaag ccacaagtct tccagaggat gcttgattcc agtggttctg 4380 cttcaaggct tccactgcaa aacactaaag atccaagaag gccttcatgg ccccagcagg 4440 ccggatcggt actgtatcaa gtcatggcag gtacagtagg ataagccact ctgtcccttc 4500 ctgggcaaag aagaaacgga ggggatggaa ttcttcctta gacttacttt tgtaaaaatg 4560 tccccacggt acttactccc cactgatgga ccagtggttt ccagtcatga gcgttagact 4620 gacttgtttg tcttccattc cattgttttg aaactcagta tgctgcccct gtcttgctgt 4680 catgaaatca gcaagagagg atgacacatc aaataataac tcggattcca gcccacattg 4740 gattcatcag catttggacc aatagcccac agctgagaat gtggaatacc taaggatagc 4800 accgcttttg ttctcgcaaa aacgtatctc ctaatttgag gctcagatga aatgcatcag 4860 gtcctttggg gcatagatca gaagactaca aaaatgaagc tgctctgaaa tctcctttag 4920 ccatcacccc aaccccccaa aattagtttg tgttacttat ggaagatagt tttctccttt 4980 tacttcactt caaaagcttt ttactcaaag agtatatgtt ccctccaggt cagctgcccc 5040 caaaccccct ccttacgctt tgtcacacaa aaagtgtctc tgccttgagt catctattca 5100 agcacttaca gctctggcca caacagggca ttttacaggt gcgaatgaca gtagcattat 5160 gagtagtgtg gaattcaggt agtaaatatg aaactagggt ttgaaattga taatgctttc 5220 acaacatttg cagatgtttt agaaggaaaa aagttccttc ctaaaataat ttctctacaa 5280 ttggaagatt ggaagattca gctagttagg agcccacctt ttttcctaat ctgtgtgtgc 5340 cctgtaacct gactggttaa cagcagtcct ttgtaaacag tgttttaaac tctcctagtc 5400 aatatccacc ccatccaatt tatcaaggaa gaaatggttc agaaaatatt ttcagcctac 5460 agttatgttc agtcacacac acatacaaaa tgttcctttt gcttttaaag taatttttga 5520 ctcccagatc agtcagagcc cctacagcat tgttaagaaa gtatttgatt tttgtctcaa 5580 tgaaaataaa actatattca tttccactct attatgctct caaatacccc taagcatcta 5640 tactagcctg gtatgggtat gaaagataca aagataaata aaacatagtc cctgattcta 5700 agaaattcac aatttagcaa aggaaatgga ctcatagatg ctaaccttaa aacaacgtga 5760 caaatgccag acaggaccca tcagccaggc actgtgagag cacagagcag ggaggttggg 5820 tcctgcctga ggagacctgg aagggaggcc tcacaggagg atgaccaggt ctcagtcagc 5880 ggggaggtgg aaagtgcagg tgcatcaggg gcaccctgac cgaggaaaca gctgccagag 5940 gcctccactg ctaaagtcca cataaggctg aggtcagtca ccctaaacaa cctgctccct 6000 ctaagccagg ggatgagctt ggagcatccc acaagttccc taaaagttgc agcccccagg 6060 gggattttga gctatcatct ctgcacatgc ttagtgagaa gactacacaa catttctaag 6120 aatctgagat tttatattgt cagttaacca ctttcattat tcattcacct caggacatgc 6180 agaaatattt cagtcagaac tgggaaacag aaggacctac attctgctgt cacttatgtg 6240 tcaagaagca gatgatcgat gaggcaggtc agttgtaagt gagtcacatt gtagcattaa 6300 attctagtat ttttgtagtt tgaaacagta acttaataaa agagcaaaag ctaaaaaaaa 6360 aaaaaaaaa 6369 <210> 204 <211> 3137 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3137) <223> EGR1 mRNA <400> 204 gagagatccc agcgcgcaga acttggggag ccgccgccgc catccgccgc cgcagccagc 60 ttccgccgcc gcaggaccgg cccctgcccc agcctccgca gccgcggcgc gtccacgccc 120 gcccgcgccc agggcgagtc ggggtcgccg cctgcacgct tctcagtgtt ccccgcgccc 180 cgcatgtaac ccggccaggc ccccgcaact gtgtcccctg cagctccagc cccgggctgc 240 acccccccgc cccgacacca gctctccagc ctgctcgtcc aggatggccg cggccaaggc 300 cgagatgcag ctgatgtccc cgctgcagat ctctgacccg ttcggatcct ttcctcactc 360 gcccaccatg gacaactacc ctaagctgga ggagatgatg ctgctgagca acggggctcc 420 ccagttcctc ggcgccgccg gggccccaga gggcagcggc agcaacagca gcagcagcag 480 cagcgggggc ggtggaggcg gcgggggcgg cagcaacagc agcagcagca gcagcacctt 540 caaccctcag gcggacacgg gcgagcagcc ctacgagcac ctgaccgcag agtcttttcc 600 tgacatctct ctgaacaacg agaaggtgct ggtggagacc agttacccca gccaaaccac 660 tcgactgccc cccatcacct atactggccg cttttccctg gagcctgcac ccaacagtgg 720 caacaccttg tggcccgagc ccctcttcag cttggtcagt ggcctagtga gcatgaccaa 780 cccaccggcc tcctcgtcct cagcaccatc tccagcggcc tcctccgcct ccgcctccca 840 gagcccaccc ctgagctgcg cagtgccatc caacgacagc agtcccattt actcagcggc 900 acccaccttc cccacgccga acactgacat tttccctgag ccacaaagcc aggccttccc 960 gggctcggca gggacagcgc tccagtaccc gcctcctgcc taccctgccg ccaagggtgg 1020 cttccaggtt cccatgatcc ccgactacct gtttccacag cagcaggggg atctgggcct 1080 gggcacccca gaccagaagc ccttccaggg cctggagagc cgcacccagc agccttcgct 1140 aacccctctg tctactatta aggcctttgc cactcagtcg ggctcccagg acctgaaggc 1200 cctcaatacc agctaccagt cccagctcat caaacccagc cgcatgcgca agtaccccaa 1260 ccggcccagc aagacgcccc cccacgaacg cccttacgct tgcccagtgg agtcctgtga 1320 tcgccgcttc tcccgctccg acgagctcac ccgccacatc cgcatccaca caggccagaa 1380 gcccttccag tgccgcatct gcatgcgcaa cttcagccgc agcgaccacc tcaccaccca 1440 catccgcacc cacacaggcg aaaagccctt cgcctgcgac atctgtggaa gaaagtttgc 1500 caggagcgat gaacgcaaga ggcataccaa gatccacttg cggcagaagg acaagaaagc 1560 agacaaaagt gttgtggcct cttcggccac ctcctctctc tcttcctacc cgtccccggt 1620 tgctacctct tacccgtccc cggttactac ctcttatcca tccccggcca ccacctcata 1680 cccatcccct gtgcccacct ccttctcctc tcccggctcc tcgacctacc catcccctgt 1740 gcacagtggc ttcccctccc cgtcggtggc caccacgtac tcctctgttc cccctgcttt 1800 cccggcccag gtcagcagct tcccttcctc agctgtcacc aactccttca gcgcctccac 1860 agggctttcg gacatgacag caaccttttc tcccaggaca attgaaattt gctaaaggga 1920 aaggggaaag aaagggaaaa gggagaaaaa gaaacacaag agacttaaag gacaggagga 1980 ggagatggcc ataggagagg agggttcctc ttaggtcaga tggaggttct cagagccaag 2040 tcctccctct ctactggagt ggaaggtcta ttggccaaca atcctttctg cccacttccc 2100 cttccccaat tactattccc tttgacttca gctgcctgaa acagccatgt ccaagttctt 2160 cacctctatc caaagaactt gatttgcatg gattttggat aaatcatttc agtatcatct 2220 ccatcatatg cctgacccct tgctcccttc aatgctagaa aatcgagttg gcaaaatggg 2280 gtttgggccc ctcagagccc tgccctgcac ccttgtacag tgtctgtgcc atggatttcg 2340 tttttcttgg ggtactcttg atgtgaagat aatttgcata ttctattgta ttatttggag 2400 ttaggtcctc acttggggga aaaaaaaaaa agaaaagcca agcaaaccaa tggtgatcct 2460 ctattttgtg atgatgctgt gacaataagt ttgaaccttt ttttttgaaa cagcagtccc 2520 agtattctca gagcatgtgt cagagtgttg ttccgttaac ctttttgtaa atactgcttg 2580 accgtactct cacatgtggc aaaatatggt ttggtttttc tttttttttt tttttgaaag 2640 tgttttttct tcgtcctttt ggtttaaaaa gtttcacgtc ttggtgcctt ttgtgtgatg 2700 cgccttgctg atggcttgac atgtgcaatt gtgagggaca tgctcacctc tagccttaag 2760 gggggcaggg agtgatgatt tgggggaggc tttgggagca aaataaggaa gagggctgag 2820 ctgagcttcg gttctccaga atgtaagaaa acaaaatcta aaacaaaatc tgaactctca 2880 aaagtctatt tttttaactg aaaatgtaaa tttataaata tattcaggag ttggaatgtt 2940 gtagttacct actgagtagg cggcgatttt tgtatgttat gaacatgcag ttcattattt 3000 tgtggttcta ttttactttg tacttgtgtt tgcttaaaca aagtgactgt ttggcttata 3060 aacacattga atgcgcttta ttgcccatgg gatatgtggt gtatatcctt ccaaaaaatt 3120 aaaacgaaaa taaagta 3137 <210> 205 <211> 5913 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(5913) <223> EMP1 mRNA <400> 205 acacacccca gtacaccagc agaggaaact tataacctcg ggaggcaggt ccttcccctc 60 agtgcggtca catacttcca gaagagcgga ccagggctgc tgccagcacc tgccactcag 120 agcgcctctg tcgctgggac ccttcagaac tctctttgct cacaagttac caaaaaaaaa 180 agagccaaca tgttggtatt gctggctggt atctttgtgg tccacatcgc tactgttatt 240 atgctatttg ttagcaccat tgccaatgtc tggttggttt ccaatacggt agatgcatca 300 gtaggtcttt ggaaaaactg taccaacatt agctgcagtg acagcctgtc atatgccagt 360 gaagatgccc tcaagacagt gcaggccttc atgattctct ctatcatctt ctgtgtcatt 420 gccctcctgg tcttcgtgtt ccagctcttc accatggaga agggaaaccg gttcttcctc 480 tcaggggcca ccacactggt gtgctggctg tgcattcttg tgggggtgtc catctacact 540 agtcattatg cgaatcgtga tggaacgcag tatcaccacg gctattccta catcctgggc 600 tggatctgct tctgcttcag cttcatcatc ggcgttctct atctggtcct gagaaagaaa 660 taaggccgga cgagttcatg gggatctggg gggtggggag gaggaagccg ttgaatctgg 720 gagggaagtg gaggttgctg tacaggaaaa accgagatag gggagggggg agggggaagc 780 aaagggggga ggtcaaatcc caaaccatta ctgaggggat tctctactgc caagcccctg 840 ccctggggag aaagtagttg gctagtactt tgatgctccc ttgatggggt ccagagagcc 900 tccctgcagc caccagactt ggcctccagc tgttcttagt gacacacact gtctggggcc 960 ccatcagctg ccacaacacc agccccactt ctgggtcatg cactgaggtc cacagaccta 1020 ctgcactgag ttaaaatagc ggtacaagtt ctggcaagag cagatactgt ctttgtgctg 1080 aatacgctaa gcctggaagc catcctgccc ttctgaccca aagcaaaaca tcacattcca 1140 gtctgaagtg cctactgggg ggctttggcc tgtgagccat tgtccctctt tggaacagat 1200 atttagctct gtggaattca gtgacaaaat gggaggagga aagagagttt gtaaggtcat 1260 gctggtgggt tagctaaacc aagaaggaga ccttttcaca atggaaaacc tgggggatgg 1320 tcagagccca gtcgagacct cacacacggc tgtccctcat ggagacctca tgccatggtc 1380 tttgctaggc ctcttgctga aagccaaggc agctcttctg gagtttctct aaagtcacta 1440 gtgaacaatt cggtggtaaa agtaccacac aaactatggg atccaagggg cagtcttgca 1500 acagtgccat gttagggtta tgtttttagg attcccctca atgcagtcag tgtttctttt 1560 aagtatacaa caggagagag atggacatgg ctcattgtag cacaatccta ttactcttcc 1620 tctaacattt ttgaggaagt tttgtctaat tatcaatatt gaggatcagg gctcctaggc 1680 tcagtggtag ctctggctta gacaccacct ggagtgatca cctcttgggg accctgccta 1740 tcccacttca caggtgaggc atggcaattc tggaagctga ttaaaacaca cataaaccaa 1800 aaccaaacaa caggcccttg ggtgaaaggt gctatataat tgtgaagtat taagcctacc 1860 gtatttcagc catgataaga acagagtgcc tgcattccca ggaaaatacg aaaatcccat 1920 gagataaata aaaatatagg tgatgggcag atcttttctt taaaataaaa aagcaaaaac 1980 tcttgtggta cctagtcaga tggtagacga gctgtctgct gccgcaggag cacctctata 2040 caggacttag aagtagtatg ttattcctgg ttaagcaggc attgctttgc cctggagcag 2100 ctattttaag ccatctcaga ttctgtctaa aggggttttt tgggaagacg ttttctttat 2160 cgccctgaga agatctaccc cagggagaat ctgagacatc ttgcctactt ttctttatta 2220 gctttctcct catccatttc ttttatacct ttcctttttg gggagttgtt atgccatgat 2280 ttttggtatt tatgtaaaag gattattact aattctattt ctctatgttt attctagtta 2340 aggaaatgtt gagggcaagc caccaaatta cctaggctga ggttagagag attggccagc 2400 aaaaactgtg ggaagatgaa ctttgtcatt atgatttcat tatcacatga ttatagaagg 2460 ctgtcttagt gcaaaaaaca tacttacatt tcagacatat ccaaagggaa tactcacatt 2520 ttgttaagaa gttgaactat gactggagta aaccatgtat tcccttatct tttacttttt 2580 ttctgtgaca tttatgtctc atgtaatttg cattactctg gtggattgtt ctagtactgt 2640 attgggcttc ttcgttaata gattatttca tatactataa ttgtaaatat tttgatacaa 2700 atgtttataa ctctagggat ataaaaacag attctgattc ccttcattgt gtgaatgttt 2760 ttttctaaaa aaaatgtgga gaaatatgga taattatgac atttatccct cattaagctg 2820 cctatcagtt tgatttggac aacttgacat ttatttgaga cattaagcta ctttctggta 2880 atatattagg catttctgca atagctcttt caggtaactg aatattatta agcatagttt 2940 tatcttgctt tgattaaacc tcttaggcaa aaaatggaac ttcataagct aatacattag 3000 aaaggggtta tgattataaa tcagaaatgc ttgtgacatt aagaaatgag gcacttgtga 3060 aatttctttg aaatagccag ctcctctaat gtgtcttcaa aatataaagt gattcacaaa 3120 ggcatgcatc acacctattt gtagcagccc attcattaca taaaccaggg catacctgtg 3180 tgggctctgt gagtgaaggg aggcttcact actttctgtg agcagtaagg actggtatct 3240 ttctgtgagc aataaggact ggataaagac tgcatatcct tgtgtcgtgt cagcaccaat 3300 acaataagga gggttttaat gtgaagcagg caatcttcca gccccttctg gtcttggatg 3360 aaatagttgc acagagtatt gcaccaaaaa tacacaatgg aggctgaaaa gttcaacata 3420 ttttaagtca attaatcaaa ttgcattgat tcttgatgct ttcttagagg cctacatgat 3480 ttcttagatt gctctgataa actatcataa ggggtccacc tcccctcatt tagctccccc 3540 agggatttct tttcccccat gtcatacacc cagtcctaaa tcaaccccca aggctatcct 3600 tccatccctt ctgcagaggg aacttttgtc agactctgca acaaactcct agctctatcc 3660 agagtgtcct ctgctgctaa gattggtatc tttctcctca aaagcctgga tggtgaatgg 3720 gggtgcatta gtcagaattc tccagagaaa cagaaaaaat aagattcgcg tgtgtgtgca 3780 aacatatata taaataaata aaaatatatt tattttaagg aattgactca catgattttg 3840 aaggcaggca agcccaaagt ctgcaagggg tgggccagca gagagctggt gctacagtgc 3900 gggtctgaaa gttgccagag tcccttttat agagaagctt aaaaaatatt tgttgaatta 3960 aatgtcttag gtagagacaa attgaattaa agtggttaag taaatactct taggtgaaat 4020 ttgtgcaaat tatgagtata aagagggtga gctacagaac tctccatgac cactcaagaa 4080 tgggacccaa aggcaaatga taacttattc attcatcaag ggataaactt gagttatcaa 4140 atggttaata gataaagatc ccactctgcc ttggatttag ccatcgcagt ccctgtgtaa 4200 aaccccaccg gctttcaggc atggaaaaaa atttcacaaa ggccttgaaa gaaggcatat 4260 gaagaccaaa aggatattga gcagggttcc atacttgaat aaaggaagaa actcccttca 4320 atgtttacta agaaatagtt agaatatagc atatcctgta tagatgaaat gtcctagcga 4380 aaatgtttaa atgtatttaa agaagagcta gattttgtgg ggggagagaa gggaatagga 4440 taggctggtg ggaggaagaa tgaaaagaag aaaacttgtt ggaaattttg gagtagattg 4500 tgaggagggg tgactcactt taaagatgta tcatttggag gtagacacga ttttcagagc 4560 acaaaacaga taaggaaaga tgtatgctga ttgtgtggag cccaagggaa ggcggggttt 4620 tggagtctta cgtggctttg tttctgaaag ggagacatgt gaagcctact cctgaggcgg 4680 gaggctgggg acatgaccat caagacctat aattgataaa caactagggg ctgggtgctg 4740 cacctacatg ctggggaaat agaaaatgaa gcagacatgt gtcccatctt cttccagctt 4800 tcagtctagc ttggaaataa atctcatacc tagagaaaat ggaggatctg tgggatgtag 4860 atgaggtggg agcatgaatg cctagggagg gaagaagaaa gattttcagt tcttcagctt 4920 ttcctcatga ccctatctca tgccatgagc aattgtctgg catctcctgt gggttggacc 4980 actgctgcat ttcttacttg ccaacatcac tttgtcccaa atgccattcc tttgttccag 5040 ggcctccttg tcttccatct ggggaactgg aggtgagaag cattataata gcctctctgc 5100 ctttatctac aatctctcca acctgtgctt tatgctgatg tcaggatggg cgttgatgga 5160 tgcttctatc actgtcgggg cagggagggc cagaacacta gcataagatg tcaatatgtc 5220 tatccatatg tcaggtccat actcaactca agcttctggt taactgctga tctattggca 5280 actccagttc ccaataagtt cctcatctcc ttctgagacc acctcagtgt ggacttaatc 5340 gtccacatca ctgtcagcat tttggttaaa accattcaac aagtctccag gaagctccaa 5400 actttccttc atcttcctgt cttcttctga gccctccaaa ctcttccaac ctctacccgt 5460 tacccagttc caaaggtgct tccacacttt caagtatctt tatagcaatg ccccactcct 5520 ggtaccaaat tcctgtatta gtctgttttc acactgctat gaagacatac ttgagactcg 5580 gtaatttata tagaaaagag gtttaattga caaaaaagct aacaaagtga gccctgattc 5640 aaaaatgact gtctacactt ggcacatgag ggactttatg atattaagag attaattaaa 5700 caacagtgga tggggaggaa gaacagactt ttgagctctt cccaatatag gaatgtgtta 5760 gttctaaaaa ttttcttaag ttgtttgctt ggaactcaga gtatattttt ccatacgaaa 5820 aattcagaac tattttattt atgatatggg ctaaaaagac ttctgtaatc tagcttggaa 5880 acttaataat cattaaactt attttcaatg aga 5913 <210> 206 <211> 3176 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3176) <223> ENO1 mRNA <400> 206 agtatctgtg ggtacccgga gcacggagat ctcgccggct ttacgttcac ctcggtgtct 60 gcagcaccct ccgcttcctc tcctaggcga cgagacccag tggctagaag ttcaccatgt 120 ctattctcaa gatccatgcc agggagatct ttgactctcg cgggaatccc actgttgagg 180 ttgatctctt cacctcaaaa ggtctcttca gagctgctgt gcccagtggt gcttcaactg 240 gtatctatga ggccctagag ctccgggaca atgataagac tcgctatatg gggaagggta 300 agccttagaa cccacagccc atggcctccc tgcttccagc cccattcctg gccttgccca 360 gtcctgtcct ctctgggtgg cacttgcact tgcaggttta tggcaggtaa acctgctgtg 420 acccatgatg ttgatggaag cagtgcacca ccttgtggac aggaaagttg gtgtgtggat 480 tccggggttc ccgagcctgc atgctctggg tcgagagttc caatgcttgc ttctattgca 540 gtttgttccc aatctgcgaa atactccttc acggttagga caggaaccca agcatgagaa 600 cagggcctgt taactaaaga aaagtttccc catctcccag gagggttctg tgggccctcc 660 agagatcatc agcctcttca cgggctagaa aggatccagg gaaggtctaa ccaatgacct 720 gccctgaatg gtgagctgca ggtgtgtcat ttagtgtgat tttcctgttg actgactcat 780 aggagccctg ctctgtggca gagctagcct ctggctgtat tcaaattgac ttagtgtgtg 840 tgcaacattg acctttctag agatagaaca tgtggccaaa ttacagaaaa gcacataggg 900 ctagatcacg cattctcagt ggggcacccg gaaaactcca aaaaggctgc agggagggga 960 caatgatgaa atcaggttgt gaaacactgg gctggtgtcg cagtggtggt gctgggtgtt 1020 cagtcccgct ttaatgctgt aagaagcact ctacacacac gaacatgtta ccatttgacc 1080 gttgtttaat ggcgtacgtg gggacttagc cggagcagga tgatgctgtg ccttgatggt 1140 aatgagtgct cagtaagtaa gcatttgtgg aagattgaac gcatggcccc tgaaatgctc 1200 tcctctgctt tcctgccccc tcactgtctc tcactcgcag tccttaatca ccggttctct 1260 tctgagtctc tctcattttt ccttcttcat cctctgctgg gcaggcgtct ccagacccat 1320 taagtatatt aatgagttcc tggcaccagc cctgtgcact caggtaactg attgaacagc 1380 ctttagtctg cagttggcgt ttccagtgca tggtcttgca aactaacctc cagtcagatc 1440 gttctgagcc agctgctgtt ttgtgtggct ctaaccctct ggggtcctag gtaggagcac 1500 tcagactggg ccggaaagtc ctccgattct ggggggaaag gggagagggg gaagaggtcc 1560 cacagaaggt cccttggtgg gcttccgcgt cggcctcaac agtggttctc tctaacaatg 1620 ctgctcaagc ctgttttaaa gttaatgtca gtaatttgat ttgattgttc cttccaggtg 1680 tctcaaaggc tgttgagcac atcaataaaa ctattgcgcc tgccctggtt agcaagaaac 1740 tgaacgtcac agaacaagag aagattgaca aactgatgat cgagatggat ggaacagaaa 1800 ataaatctaa gtttggtgcg aacgccattc tgggggtgtc ccttgccgtc tgcaaagctg 1860 gtgccgttga gaagggggtc cccctgtacc gccacatcgc tgacttggct ggcaactctg 1920 aagtcatcct gccagtcccg gcgttcaatg tcatcaatgg cggttctcat gctggcaaca 1980 agctggccat gcaggagttc atgatcctcc cagtcggtgc agcaaacttc agggaagcca 2040 tgcgcattgg agcagaggtt taccacaacc tgaagaatgt catcaaggag aaatatggga 2100 aagatgccac caatgtgggg gatgaaggcg ggtttgctcc caacatcctg gagaataaag 2160 aaggcctgga gctgctgaag actgctattg ggaaagctgg ctacactgat aaggtggtca 2220 tcggcatgga cgtagcggcc tccgagttct tcaggtctgg gaagtatgac ctggacttca 2280 agtctcccga tgaccccagc aggtacatct cgcctgacca gctggctgac ctgtacaagt 2340 ccttcatcaa ggactaccca gtggtgtcta tcgaagatcc ctttgaccag gatgactggg 2400 gagcttggca gaagttcaca gccagtgcag gaatccaggt agtgggggat gatctcacag 2460 tgaccaaccc aaagaggatc gccaaggccg tgaacgagaa gtcctgcaac tgcctcctgc 2520 tcaaagtcaa ccagattggc tccgtgaccg agtctcttca ggcgtgcaag ctggcccagg 2580 ccaatggttg gggcgtcatg gtgtctcatc gttcggggga gactgaagat accttcatcg 2640 ctgacctggt tgtggggctg tgcactgggc agatcaagac tggtgcccct tgccgatctg 2700 agcgcttggc caagtacaac cagctcctca gaattgaaga ggagctgggc agcaaggcta 2760 agtttgccgg caggaacttc agaaacccct tggccaagta agctgtgggc aggcaagccc 2820 ttcggtcacc tgttggctac acagacccct cccctcgtgt cagctcaggc agctcgaggc 2880 ccccgaccaa cacttgcagg ggtccctgct agttagcgcc ccaccgccgt ggagttcgta 2940 ccgcttcctt agaacttcta cagaagccaa gctccctgga gccctgttgg cagctctagc 3000 tttgcagtcg tgtaattggc ccaagtcatt gtttttctcg cctcactttc caccaagtgt 3060 ctagagtcat gtgagcctcg tgtcatctcc ggggtggcca caggctagat ccccggtggt 3120 tttgtgctca aaataaaaag cctcagtgac ccatgagaaa aaaaaaaaaa aaaaaa 3176 <210> 207 <211> 3097 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3097) <223> ERRFI1 mRNA <400> 207 gacggcggtc cggtgcgagg cagagtgcta gcgggagcgc gagccagcaa gaggcgcctg 60 cgcgatgtcc gggcccctga gcccgcggcg ctgagccagc cgggacggac atgcgcggga 120 gggcgccgcg gggcagccgc cgctcctccg ggggaatgaa agctactggt tgattttaaa 180 gtgcctgggc ctcacaggtt tggagatgtc ccagaataag gcacaatgtc aatagcagga 240 gttgctgctc aggagatcag agtcccatta aaaactggat ttctacataa tggccgagcc 300 atggggaata tgaggaagac ctactggagc agtcgcagtg agtttaaaaa caacttttta 360 aatattgacc cgataaccat ggcctacagt ctgaactctt ctgctcagga gcgcctaata 420 ccacttgggc atgcttccaa atctgctccg atgaatggcc actgctttgc agaaaatggt 480 ccatctcaaa agtccagctt gccccctctt cttattcccc caagtgaaaa cttgggacca 540 catgaagagg atcaagttgt atgtggtttt aagaaactca cagtgaatgg ggtttgtgct 600 tccacccctc cactgacacc cataaaaaac tccccttccc ttttcccctg tgcccctctt 660 tgtgaacggg gttctaggcc tcttccaccg ttgccaatct ctgaagccct ctctctggat 720 gacacagact gtgaggtgga attcctaact agctcagata cagacttcct tttagaagac 780 tctacacttt ctgatttcaa atatgatgtt cctggcaggc gaagcttccg tgggtgtgga 840 caaatcaact atgcatattt tgatacccca gctgtttctg cagcagatct cagctatgtg 900 tctgaccaaa atggaggtgt cccagatcca aatcctcctc cacctcagac ccaccgaaga 960 ttaagaaggt ctcattcggg accagctggc tcctttaaca agccagccat aaggatatcc 1020 aactgttgta tacacagagc ttctcctaac tccgatgaag acaaacctga ggttcccccc 1080 agagttccca tacctcctag accagtaaag ccagattata gaagatggtc agcagaagtt 1140 acttcgagca cctatagtga tgaagacagg cctcccaaag taccgccaag agaacctttg 1200 tcaccgagta actcgcgcac accgagtccc aaaagccttc cgtcttacct caatggggtc 1260 atgcccccga cacagagctt tgcccctgat cccaagtatg tcagcagcaa agcactgcaa 1320 agacagaaca gcgaaggatc tgccagtaag gttccttgca ttctgcccat tattgaaaat 1380 gggaagaagg ttagttcaac acattattac ctactacctg aacgaccacc atacctggac 1440 aaatatgaaa aattttttag ggaagcagaa gaaacaaatg gaggcgccca aatccagcca 1500 ttacctgctg actgcggtat atcttcagcc acagaaaagc cagactcaaa aacaaaaatg 1560 gatctgggtg gccacgtgaa gcgtaaacat ttatcctatg tggtttctcc ttagaccttg 1620 gggtcatggt tcagcagagg ttacatagga gcaaatggtt ctcaattttc cagtttgatt 1680 gaagtgcaga gaaaaatccc ttagattgca aaataaaata gttgaactct ctgtcttcat 1740 gtggaaggtt tagagcagtt gtgagatgct gttatgctga gaaaccctga ctttgttagt 1800 gttggaaaaa agtcttacaa gtctataatt taaagatgtg atggtgggga ggggaggatg 1860 gggaagcttt ttatatatgc atacattaca tacctatata taaacttgtg gtataaccat 1920 agaccatagc tgcaggttaa ccaattagtt actatcgtag agtaatatat attcagaata 1980 ataaactcaa gctggagaaa tgagtcctga tagactgaaa attgagcaaa tggaagaaga 2040 tacagtattg tttagatcag aatcattaaa aaatattttt gtttagtaag tttgaagatt 2100 tctggctttt aggccttttc tattttgttc catttatttt tgcaggcaat cttttccatg 2160 gagggcaggg tatccattct ttaccatggg tgtacctgct taggttaaaa atcataccaa 2220 ggcctcatac ttccaggttt catgttgcgt cttgttgagg gagggagagc aggttacttg 2280 gcaaccatat tgtcacctgt acctgtcaca catcttgaaa aataaaacga taatagaact 2340 agtgactaat tttcccttac agttcctgct tggtcccacc cactgaagta gctcatcgta 2400 gtgcgggccg tattagaggc agtggggtac gttagactca gatggaaaag tattctaggt 2460 gccagtgtta ggatgtcagt tttacaaaat aatgaagcaa ttagctatgt gattgagagt 2520 tattgtttgg ggatgtgtgt tgtggttttg cttttttttt ttagactgta ttaataaaca 2580 tacaacacaa gctggccttg tgttgctggt tcctattcag tatttcctgg ggattgtttg 2640 ctttttaagt aaaacacttc tgacccatag ctcagtatgt ctgaattcca gaggtcacat 2700 cagcatcttt ctgctttgaa aactctcaca gctgtggctg cttcacttag atgcagtgag 2760 acacatagtt ggtgttccga ttttcacatc cttccatgta tttatcttga agagataagc 2820 acagaagaga aggtgctcac taacagaggt acattactgc aatgttctct taacagttaa 2880 acaagctgtt tacagtttaa actgctgaat attatttgag ctatttaaag cttattatat 2940 tttagtatga actaaatgaa ggttaaaaca tgcttaagaa aaatgcactg atttctgcat 3000 tatgtgtaca gtattggaca aaggatttta ttcattttgt tgcattattt tgaatattgt 3060 cttttcattt taataaagtt ataatactta tttatga 3097 <210> 208 <211> 2089 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2089) <223> ESM1 mRNA <400> 208 agtttggacg gctgcttccc accagcaaag accacgactg gagagccgag ccggaggcag 60 ctgggaaaca tgaagagcgt cttgctgctg accacgctcc tcgtgcctgc acacctggtg 120 gccgcctgga gcaataatta tgcggtggac tgccctcaac actgtgacag cagtgagtgc 180 aaaagcagcc cgcgctgcaa gaggacagtg ctcgacgact gtggctgctg ccgagtgtgc 240 gctgcagggc ggggagaaac ttgctaccgc acagtctcag gcatggatgg catgaagtgt 300 ggcccggggc tgaggtgtca gccttctaat ggggaggatc cttttggtga agagtttggt 360 atctgcaaag actgtcccta cggcaccttc gggatggatt gcagagagac ctgcaactgc 420 cagtcaggca tctgtgacag ggggacggga aaatgcctga aattcccctt cttccaatat 480 tcagtaacca agtcttccaa cagatttgtt tctctcacgg agcatgacat ggcatctgga 540 gatggcaata ttgtgagaga agaagttgtg aaagagaatg ctgccgggtc tcccgtaatg 600 aggaaatggt taaatccacg ctgatcccgg ctgtgatttc tgagagaagg ctctattttc 660 gtgattgttc aacacacagc caacatttta ggaactttct agattatagc ataaggacat 720 gtaatttttg aagaccaaat gtgatgcatg gtggatccag aaaacaaaaa gtaggatact 780 tacaatccat aacatccata tgactgaaca cttgtatgtg tttgttaaat attcgaatgc 840 atgtagattt gttaaatgtg tgtgtatagt aacactgaag aactaaaaat gcaatttagg 900 taatcttacg tggagacagg tcaaccaaag agggagctag gcaaagctga agaccgcagt 960 gagtcaaatt agttctttga ctttgatgta cattaatgtt gggatatgga atgaagactt 1020 aagagcagga gaagatgggg agggggtggg agtgggaaat aaaatattta gcccttcctt 1080 ggtaggtagc ttctctagaa tttaattgtg cttttttttt tttttttggc tttgggaaaa 1140 gtcaaaataa aacaaccaga aaacccctga aggaagtaag atgtttgaag cttatggaaa 1200 tttgagtaac aaacagcttt gaactgagag caatttcaaa aggctgctga tgtagttccc 1260 gggttacctg tatctgaagg acggttctgg ggcataggaa acacatacac ttccataaat 1320 agctttaacg tatgccacct cagagataaa tctaagaagt attttaccca ctggtggttt 1380 gtgtgtgtat gaaggtaaat atttatatat ttttataaat aaatgtgtta gtgcaagtca 1440 tcttccctac ccatatttat catcctcttg aggaaagaaa tctagtatta tttgttgaaa 1500 atggttagaa taaaactatg actctataag gttttcaaac atctgaggca tgataaattt 1560 attatccata attatagtaa taataacctt aataagcata agaaaaacag agtcactctg 1620 gatttcaaaa atgtcaaaaa atgagcaaca gagggtcctt atttaaacat aagtgctgtg 1680 acttaggtga attttcaatt taaggtagaa aataagtttt taggaggttt gtaaaagaag 1740 aatcaatttt cagcagaaaa catgtcaact ttaaaatata gtttattttc atattttttt 1800 cttttaaact tggttgataa gtggaattag gagtatattt gaaagaatct tagcacaaac 1860 aggactgttg tactagatgt tcttaggaaa tatctcagaa gtattttatt tgaagtgaag 1920 aacttattta agaattattt cagtatttac ctgtatttta ttcttgaagt tggccaacag 1980 agttgtgaat gtgtgtggga aggcctttga atgtaaagct gcataagctg ttaggttttg 2040 ttttaaaagg acatgtttat tattgttcaa taaaaaagaa caagataca 2089 <210> 209 <211> 2248 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2248) <223> FGA mRNA <400> 209 aggatgggaa ctaggagtgg cagcaatcct ttctttcagc tggagtgctc ctcaggagcc 60 agccccaccc ttagaaaaga tgttttccat gaggatcgtc tgcctggtcc taagtgtggt 120 gggcacagca tggactgcag atagtggtga aggtgacttt ctagctgaag gaggaggcgt 180 gcgtggccca agggttgtgg aaagacatca atctgcctgc aaagattcag actggccctt 240 ctgctctgat gaagactgga actacaaatg cccttctggc tgcaggatga aagggttgat 300 tgatgaagtc aatcaagatt ttacaaacag aataaataag ctcaaaaatt cactatttga 360 atatcagaag aacaataagg attctcattc gttgaccact aatataatgg aaattttgag 420 aggcgatttt tcctcagcca ataaccgtga taatacctac aaccgagtgt cagaggatct 480 gagaagcaga attgaagtcc tgaagcgcaa agtcatagaa aaagtacagc atatccagct 540 tctgcagaaa aatgttagag ctcagttggt tgatatgaaa cgactggagg tggacattga 600 tattaagatc cgatcttgtc gagggtcatg cagtagggct ttagctcgtg aagtagatct 660 gaaggactat gaagatcagc agaagcaact tgaacaggtc attgccaaag acttacttcc 720 ctctagagat aggcaacact taccactgat aaaaatgaaa ccagttccag acttggttcc 780 cggaaatttt aagagccagc ttcagaaggt acccccagag tggaaggcat taacagacat 840 gccgcagatg agaatggagt tagagagacc tggtggaaat gagattactc gaggaggctc 900 cacctcttat ggaaccggat cagagacgga aagccccagg aaccctagca gtgctggaag 960 ctggaactct gggagctctg gacctggaag tactggaaac cgaaaccctg ggagctctgg 1020 gactggaggg actgcaacct ggaaacctgg gagctctgga cctggaagta ctggaagctg 1080 gaactctggg agctctggaa ctggaagtac tggaaaccaa aaccctggga gccctagacc 1140 tggtagtacc ggaacctgga atcctggcag ctctgaacgc ggaagtgctg ggcactggac 1200 ctctgagagc tctgtatctg gtagtactgg acaatggcac tctgaatctg gaagttttag 1260 gccagatagc ccaggctctg ggaacgcgag gcctaacaac ccagactggg gcacatttga 1320 agaggtgtca ggaaatgtaa gtccagggac aaggagagag taccacacag aaaaactggt 1380 cacttctaaa ggagataaag agctcaggac tggtaaagag aaggtcacct ctggtagcac 1440 aaccaccacg cgtcgttcat gctctaaaac cgttactaag actgttattg gtcctgatgg 1500 tcacaaagaa gttaccaaag aagtggtgac ctccgaagat ggttctgact gtcccgaggc 1560 aatggattta ggcacattgt ctggcatagg tactctggat gggttccgcc ataggcaccc 1620 tgatgaagct gccttcttcg acactgcctc aactggaaaa acattcccag gtttcttctc 1680 acctatgtta ggagagtttg tcagtgagac tgagtctagg ggctcagaat ctggcatctt 1740 cacaaataca aaggaatcca gttctcatca ccctgggata gctgaattcc cttcccgtgg 1800 taaatcttca agttacagca aacaatttac tagtagcacg agttacaaca gaggagactc 1860 cacatttgaa agcaagagct ataaaatggc agatgaggcc ggaagtgaag ccgatcatga 1920 aggaacacat agcaccaaga gaggccatgc taaatctcgc cctgtcagag gtatccacac 1980 ttctcctttg gggaagcctt ccctgtcccc ctagactaag ttaaatattt ctgcacagtg 2040 ttcccatggc cccttgcatt tccttcttaa ctctctgtta cacgtcattg aaactacact 2100 tttttggtct gtttttgtgc tagactgtaa gttccttggg ggcagggcct ttgtctgtct 2160 catctctgta ttcccaaatg cctaacagta cagagccatg actcaataaa tacatgttaa 2220 atggatgaat gaattcctct gaaactct 2248 <210> 210 <211> 6781 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6781) <223> FGF2 mRNA <400> 210 cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc 60 gcgggaggct ggtgggtgtg gggggtggag atgtagaaga tgtgacgccg cggcccggcg 120 ggtgccagat tagcggacgc ggtgcccgcg gttgcaacgg gatcccgggc gctgcagctt 180 gggaggcggc tctccccagg cggcgtccgc ggagacaccc atccgtgaac cccaggtccc 240 gggccgccgg ctcgccgcgc accaggggcc ggcggacaga agagcggccg agcggctcga 300 ggctggggga ccgcgggcgc ggccgcgcgc tgccgggcgg gaggctgggg ggccggggcc 360 ggggccgtgc cccggagcgg gtcggaggcc ggggccgggg ccgggggacg gcggctcccc 420 gcgcggctcc agcggctcgg ggatcccggc cgggccccgc agggaccatg gcagccggga 480 gcatcaccac gctgcccgcc ttgcccgagg atggcggcag cggcgccttc ccgcccggcc 540 acttcaagga ccccaagcgg ctgtactgca aaaacggggg cttcttcctg cgcatccacc 600 ccgacggccg agttgacggg gtccgggaga agagcgaccc tcacatcaag ctacaacttc 660 aagcagaaga gagaggagtt gtgtctatca aaggagtgtg tgctaaccgt tacctggcta 720 tgaaggaaga tggaagatta ctggcttcta aatgtgttac ggatgagtgt ttcttttttg 780 aacgattgga atctaataac tacaatactt accggtcaag gaaatacacc agttggtatg 840 tggcactgaa acgaactggg cagtataaac ttggatccaa aacaggacct gggcagaaag 900 ctatactttt tcttccaatg tctgctaaga gctgatttta atggccacat ctaatctcat 960 ttcacatgaa agaagaagta tattttagaa atttgttaat gagagtaaaa gaaaataaat 1020 gtgtatagct cagtttggat aattggtcaa acaatttttt atccagtagt aaaatatgta 1080 accattgtcc cagtaaagaa aaataacaaa agttgtaaaa tgtatattct cccttttata 1140 ttgcatctgc tgttacccag tgaagcttac ctagagcaat gatctttttc acgcatttgc 1200 tttattcgaa aagaggcttt taaaatgtgc atgtttagaa acaaaatttc ttcatggaaa 1260 tcatatacat tagaaaatca cagtcagatg tttaatcaat ccaaaatgtc cactatttct 1320 tatgtcattc gttagtctac atgtttctaa acatataaat gtgaatttaa tcaattcctt 1380 tcatagtttt ataattctct ggcagttcct tatgatagag tttataaaac agtcctgtgt 1440 aaactgctgg aagttcttcc acagtcaggt caattttgtc aaacccttct ctgtacccat 1500 acagcagcag cctagcaact ctgctggtga tgggagttgt attttcagtc ttcgccaggt 1560 cattgagatc catccactca catcttaagc attcttcctg gcaaaaattt atggtgaatg 1620 aatatggctt taggcggcag atgatataca tatctgactt cccaaaagct ccaggatttg 1680 tgtgctgttg ccgaatactc aggacggacc tgaattctga ttttatacca gtctcttcaa 1740 aaacttctcg aaccgctgtg tctcctacgt aaaaaaagag atgtacaaat caataataat 1800 tacactttta gaaactgtat catcaaagat tttcagttaa agtagcatta tgtaaaggct 1860 caaaacatta ccctaacaaa gtaaagtttt caatacaaat tctttgcctt gtggatatca 1920 agaaatccca aaatattttc ttaccactgt aaattcaaga agcttttgaa atgctgaata 1980 tttctttggc tgctacttgg aggcttatct acctgtacat ttttggggtc agctcttttt 2040 aacttcttgc tgctcttttt cccaaaaggt aaaaatatag attgaaaagt taaaacattt 2100 tgcatggctg cagttccttt gtttcttgag ataagattcc aaagaactta gattcatttc 2160 ttcaacaccg aaatgctgga ggtgtttgat cagttttcaa gaaacttgga atataaataa 2220 ttttataatt caacaaaggt tttcacattt tataaggttg atttttcaat taaatgcaaa 2280 tttgtgtggc aggattttta ttgccattaa catatttttg tggctgcttt ttctacacat 2340 ccagatggtc cctctaactg ggctttctct aattttgtga tgttctgtca ttgtctccca 2400 aagtatttag gagaagccct ttaaaaagct gccttcctct accactttgc tggaaagctt 2460 cacaattgtc acagacaaag atttttgttc caatactcgt tttgcctcta tttttcttgt 2520 ttgtcaaata gtaaatgata tttgcccttg cagtaattct actggtgaaa aacatgcaaa 2580 gaagaggaag tcacagaaac atgtctcaat tcccatgtgc tgtgactgta gactgtctta 2640 ccatagactg tcttacccat cccctggata tgctcttgtt ttttccctct aatagctatg 2700 gaaagatgca tagaaagagt ataatgtttt aaaacataag gcatttgtct gccatttttc 2760 aattacatgc tgacttccct tacaattgag atttgcccat aggttaaaca tggttagaaa 2820 caactgaaag cataaaagaa aaatctaggc cgggtgcagt ggctcatgcc tatattccct 2880 gcactttggg aggccaaagc aggaggatcg cttgagccca ggagttcaag accaacctgg 2940 tgaaaccccg tctctacaaa aaaacacaaa aaatagccag gcatggtggc gtgtacatgt 3000 ggtctcagat acttgggagg ctgaggtggg agggttgatc acttgaggct gagaggtcaa 3060 ggttgcagtg agccataatc gtgccactgc agtccagcct aggcaacaga gtgagacttt 3120 gtctcaaaaa aagagaaatt ttccttaata agaaaagtaa tttttactct gatgtgcaat 3180 acatttgtta ttaaatttat tatttaagat ggtagcacta gtcttaaatt gtataaaata 3240 tcccctaaca tgtttaaatg tccattttta ttcattatgc tttgaaaaat aattatgggg 3300 aaatacatgt ttgttattaa atttattatt aaagatagta gcactagtct taaatttgat 3360 ataacatctc ctaacttgtt taaatgtcca tttttattct ttatgtttga aaataaatta 3420 tggggatcct atttagctct tagtaccact aatcaaaagt tcggcatgta gctcatgatc 3480 tatgctgttt ctatgtcgtg gaagcactgg atgggggtag tgagcaaatc tgccctgctc 3540 agcagtcacc atagcagctg actgaaaatc agcactgcct gagtagtttt gatcagttta 3600 acttgaatca ctaactgact gaaaattgaa tgggcaaata agtgcttttg tctccagagt 3660 atgcgggaga cccttccacc tcaagatgga tatttcttcc ccaaggattt caagatgaat 3720 tgaaattttt aatcaagata gtgtgcttta ttctgttgta ttttttatta ttttaatata 3780 ctgtaagcca aactgaaata acatttgctg ttttataggt ttgaagaaca taggaaaaac 3840 taagaggttt tgtttttatt tttgctgatg aagagatatg tttaaatatg ttgtattgtt 3900 ttgtttagtt acaggacaat aatgaaatgg agtttatatt tgttatttct attttgttat 3960 atttaataat agaattagat tgaaataaaa tataatggga aataatctgc agaatgtggg 4020 ttttcctggt gtttccctct gactctagtg cactgatgat ctctgataag gctcagctgc 4080 tttatagttc tctggctaat gcagcagata ctcttcctgc cagtggtaat acgatttttt 4140 aagaaggcag tttgtcaatt ttaatcttgt ggataccttt atactcttag ggtattattt 4200 tatacaaaag ccttgaggat tgcattctat tttctatatg accctcttga tatttaaaaa 4260 acactatgga taacaattct tcatttacct agtattatga aagaatgaag gagttcaaac 4320 aaatgtgttt cccagttaac tagggtttac tgtttgagcc aatataaatg tttaactgtt 4380 tgtgatggca gtattcctaa agtacattgc atgttttcct aaatacagag tttaaataat 4440 ttcagtaatt cttagatgat tcagcttcat cattaagaat atcttttgtt ttatgttgag 4500 ttagaaatgc cttcatatag acatagtctt tcagacctct actgtcagtt ttcatttcta 4560 gctgctttca gggttttatg aattttcagg caaagcttta atttacacta agcttaggaa 4620 gtatggctaa tgccaacggc agtttttttc ttcttaattc cacatgactg aggcatatat 4680 gatctctggg taggtgagtt gttgtgacaa ccacaagcac tttttttttt tttaaagaaa 4740 aaaaggtagt gaatttttaa tcatctggac tttaagaagg attctggagt atacttaggc 4800 ctgaaattat atatatttgg cttggaaatg tgtttttctt caattacatc tacaagtaag 4860 tacagctgaa attcagagga cccataagag ttcacatgaa aaaaatcaat ttatttgaaa 4920 aggcaagatg caggagagag gaagccttgc aaacctgcag actgcttttt gcccaatata 4980 gattgggtaa ggctgcaaaa cataagctta attagctcac atgctctgct ctcacgtggc 5040 accagtggat agtgtgagag aattaggctg tagaacaaat ggccttctct ttcagcattc 5100 acaccactac aaaatcatct tttatatcaa cagaagaata agcataaact aagcaaaagg 5160 tcaataagta cctgaaacca agattggcta gagatatatc ttaatgcaat ccattttctg 5220 atggattgtt acgagttggc tatataatgt atgtatggta ttttgatttg tgtaaaagtt 5280 ttaaaaatca agctttaagt acatggacat ttttaaataa aatatttaaa gacaatttag 5340 aaaattgcct taatatcatt gttggctaaa tagaataggg gacatgcata ttaaggaaaa 5400 ggtcatggag aaataatatt ggtatcaaac aaatacattg atttgtcatg atacacattg 5460 aatttgatcc aatagtttaa ggaataggta ggaaaatttg gtttctattt ttcgatttcc 5520 tgtaaatcag tgacataaat aattcttagc ttattttata tttccttgtc ttaaatactg 5580 agctcagtaa gttgtgttag gggattattt ctcagttgag actttcttat atgacatttt 5640 actatgtttt gactacctga ctattaaaaa taaatagtag atacaatttt cataaagtga 5700 agaattatat aatcactgct ttataactga ctttattata tttatttcaa agttcattta 5760 aaggctacta ttcatcctct gtgatggaat ggtcaggaat ttgttttctc atagtttaat 5820 tccaacaaca atattagtcg tatccaaaat aacctttaat gctaaacttt actgatgtat 5880 atccaaagct tctcattttc agacagatta atccagaagc agtcataaac agaagaatag 5940 gtggtatgtt cctaatgata ttatttctac taatggaata aactgtaata ttagaaatta 6000 tgctgctaat tatatcagct ctgaggtaat ttctgaaatg ttcagactca gtcggaacaa 6060 attggaaaat ttaaattttt attcttagct ataaagcaag aaagtaaaca cattaatttc 6120 ctcaacattt ttaagccaat taaaaatata aaagatacac accaatatct tcttcaggct 6180 ctgacaggcc tcctggaaac ttccacatat ttttcaactg cagtataaag tcagaaaata 6240 aagttaacat aactttcact aacacacaca tatgtagatt tcacaaaatc cacctataat 6300 tggtcaaagt ggttgagaat atatttttta gtaattgcat gcaaaatttt tctagcttcc 6360 atcctttctc cctcgtttct tctttttttg ggggagctgg taactgatga aatcttttcc 6420 caccttttct cttcaggaaa tataagtggt tttgtttggt taacgtgata cattctgtat 6480 gaatgaaaca ttggagggaa acatctactg aatttctgta atttaaaata ttttgctgct 6540 agttaactat gaacagatag aagaatctta cagatgctgc tataaataag tagaaaatat 6600 aaatttcatc actaaaatat gctattttaa aatctatttc ctatattgta tttctaatca 6660 gatgtattac tcttattatt tctattgtat gtgttaatga ttttatgtaa aaatgtaatt 6720 gcttttcatg agtagtatga ataaaattga ttagtttgtg ttttcttgtc tcccaaaaaa 6780 a 6781 <210> 211 <211> 3936 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3936) <223> FGF7 mRNA <400> 211 agttttaatt gcttccaatg aggtcagcaa aggtatttat cgaaaagccc tgaataaaag 60 gctcacacac acacacaagc acacacgcgc tcacacacag agagaaaatc cttctgcctg 120 ttgatttatg gaaacaatta tgattctgct ggagaacttt tcagctgaga aatagtttgt 180 agctacagta gaaaggctca agttgcacca ggcagacaac agacatggaa ttcttatata 240 tccagctgtt agcaacaaaa caaaagtcaa atagcaaaca gcgtcacagc aactgaactt 300 actacgaact gtttttatga ggatttatca acagagttat ttaaggagga atcctgtgtt 360 gttatcagga actaaaagga taaggctaac aatttggaaa gagcaactac tctttcttaa 420 atcaatctac aattcacaga taggaagagg tcaatgacct aggagtaaca atcaactcaa 480 gattcatttt cattatgtta ttcatgaaca cccggagcac tacactataa tgcacaaatg 540 gatactgaca tggatcctgc caactttgct ctacagatca tgctttcaca ttatctgtct 600 agtgggtact atatctttag cttgcaatga catgactcca gagcaaatgg ctacaaatgt 660 gaactgttcc agccctgagc gacacacaag aagttatgat tacatggaag gaggggatat 720 aagagtgaga agactcttct gtcgaacaca gtggtacctg aggatcgata aaagaggcaa 780 agtaaaaggg acccaagaga tgaagaataa ttacaatatc atggaaatca ggacagtggc 840 agttggaatt gtggcaatca aaggggtgga aagtgaattc tatcttgcaa tgaacaagga 900 aggaaaactc tatgcaaaga aagaatgcaa tgaagattgt aacttcaaag aactaattct 960 ggaaaaccat tacaacacat atgcatcagc taaatggaca cacaacggag gggaaatgtt 1020 tgttgcctta aatcaaaagg ggattcctgt aagaggaaaa aaaacgaaga aagaacaaaa 1080 aacagcccac tttcttccta tggcaataac ttaattgcat atggtatata aagaaccagt 1140 tccagcaggg agatttcttt aagtggactg ttttctttct tctcaaaatt ttctttcctt 1200 ttatttttta gtaatcaaga aaggctggaa aactactgaa aaactgatca agctggactt 1260 gtgcatttat gtttgtttta agacactgca ttaaagaaag atttgaaaag tatacacaaa 1320 aatcagattt agtaactaaa ggttgtaaaa aattgtaaaa ctggttgtac aatcatgatg 1380 ttagtaacag taattttttt cttaaattaa tttaccctta agagtatgtt agatttgatt 1440 atctgataat gattatttaa atattcctat ctgcttataa aatggctgct ataataataa 1500 taatacagat gttgttatat aaggtatatc agacctacag gcttctggca ggatttgtca 1560 gataatcaag ccacactaac tatggaaaat gagcagcatt ttaaatgctt tctagtgaaa 1620 aattataatc tacttaaact ctaatcagaa aaaaaattct caaaaaaact attatgaaag 1680 tcaataaaat agataattta acaaaagtac aggattagaa catgcttata cctataaata 1740 agaacaaaat ttctaatgct gctcaagtgg aaagggtatt gctaaaagga tgtttccaaa 1800 aatcttgtat ataagatagc aacagtgatt gatgataata ctgtacttca tcttacttgc 1860 cacaaaataa cattttataa atcctcaaag taaaattgag aaatctttaa gtttttttca 1920 agtaacataa tctatctttg tataattcat atttgggaat atggctttta ataatgttct 1980 tcccacaaat aatcatgctt ttttcctatg gttacagcat taaactctat tttaagttgt 2040 ttttgaactt tattgttttg ttatttaagt ttatgttatt tataaaaaaa aaaccttaat 2100 aagctgtatc tgtttcatat gcttttaatt ttaaaggaat aacaaaactg tctggctcaa 2160 cggcaagttt ccctcccttt tctgactgac actaagtcta gcacacagca cttgggccag 2220 caaatcctgg aaggcagaca aaaataagag cctgaagcaa tgcttacaat agatgtctca 2280 cacagaacaa tacaaatatg taaaaaatct ttcaccacat attcttgcca attaattgga 2340 tcatataagt aaaatcatta caaatataag tatttacagg attttaaagt tagaatatat 2400 ttgaatgcat gggtagaaaa tatcatattt taaaactatg tatatttaaa tttagtaatt 2460 ttctaatctc tagaaatctc tgctgttcaa aaggtggcag cactgaaagt tgttttcctg 2520 ttagatggca agagcacaat gcccaaaata gaagatgcag ttaagaataa ggggccctga 2580 atgtcatgaa ggcttgaggt cagcctacag ataacaggat tattacaagg atgaatttcc 2640 acttcaaaag tctttcattg gcagatcttg gtagcacttt atatgttcac caatgggagg 2700 tcaatattta tctaatttaa aaggtatgct aaccactgtg gttttaattt caaaatattt 2760 gtcattcaag tccctttaca taaatagtat ttggtaatac atttatagat gagagttata 2820 tgaaaaggct aggtcaacaa aaacaataga ttcatttaat tttcctgtgg ttgacctata 2880 cgaccaggat gtagaaaact agaaagaact gcccttcctc agatatactc ttgggagaga 2940 gcatgaatgg tattctgaac tatcacctga ttcaaggact ttgctagcta ggttttgagg 3000 tcaggcttca gtaactgtag tcttgtgagc atattgaggg cagaggagga cttagttttt 3060 catatgtgtt tccttagtgc ctagcagact atctgttcat aatcagtttt cagtgtgaat 3120 tcactgaatg tttatagaca aaagaaaata cacactaaaa ctaatcttca ttttaaaagg 3180 gtaaaacatg actatacaga aatttaaata gaaatagtgt atatacatat aaaatacaag 3240 ctatgttagg accaaatgct ctttgtctat ggagttatac ttccatcaaa ttacatagca 3300 atgctgaatt aggcaaaacc aacatttagt ggtaaatcca ttcctggtag tataagtcac 3360 ctaaaaaaga cttctagaaa tatgtacttt aattatttgt ttttctccta tttttaaatt 3420 tattatgcaa attttagaaa ataaaatttg ctctagttac acacctttag aattctagaa 3480 tattaaaact gtaaggggcc tccatccctc ttactcattt gtagtctagg aaattgagat 3540 tttgatacac ctaaggtcac gcagctgggt agatatacag ctgtcacaag agtctagatc 3600 agttagcaca tgctttctac tcttcgatta ttagtattat tagctaatgg tctttggcat 3660 gtttttgttt tttatttctg ttgagatata gcctttacat ttgtacacaa atgtgactat 3720 gtcttggcaa tgcacttcat acacaatgac taatctatac tgtgatgatt tgactcaaaa 3780 ggagaaaaga aattatgtag ttttcaattc tgattcctat tcaccttttg tttatgaatg 3840 gaaagctttg tgcaaaatat acatataagc agagtaagcc ttttaaaaat gttctttgaa 3900 agataaaatt aaatacatga gtttctaaca attaga 3936 <210> 212 <211> 627 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(627) <223> FGF10 mRNA <400> 212 atgtggaaat ggatactgac acattgtgcc tcagcctttc cccacctgcc cggctgctgc 60 tgctgctgct ttttgttgct gttcttggtg tcttccgtcc ctgtcacctg ccaagccctt 120 ggtcaggaca tggtgtcacc agaggccacc aactcttctt cctcctcctt ctcctctcct 180 tccagcgcgg gaaggcatgt gcggagctac aatcaccttc aaggagatgt ccgctggaga 240 aagctattct ctttcaccaa gtactttctc aagattgaga agaacgggaa ggtcagcggg 300 accaagaagg agaactgccc gtacagcatc ctggagataa catcagtaga aatcggagtt 360 gttgccgtca aagccattaa cagcaactat tacttagcca tgaacaagaa ggggaaactc 420 tatggctcaa aagaatttaa caatgactgt aagctgaagg agaggataga ggaaaatgga 480 tacaatacct atgcatcatt taactggcag cataatggga ggcaaatgta tgtggcattg 540 aatggaaaag gagctccaag gagaggacag aaaacacgaa ggaaaaacac ctctgctcac 600 tttcttccaa tggtggtaca ctcatag 627 <210> 213 <211> 1759 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1759) <223> FOSL1 mRNA <400> 213 acgggccaag gcggcgcgtc tcgggggtgg agcctggagg tgaccgcgcc gctgcaacgc 60 ccccaccccc cgcggtcgca gtggttcagc ccgagaactt ttcattcata aaaagaaaag 120 actccgcacg gcgcgggtga gtcagaaccc agcagccgtg taccccgcag agccgccagc 180 cccgggcatg ttccgagact tcggggaacc cggcccgagc tccgggaacg gcggcgggta 240 cggcggcccc gcgcagcccc cggccgcagc gcaggcagcc cagcagaagt tccacctggt 300 gccaagcatc aacaccatga gtggcagtca ggagctgcag tggatggtac agcctcattt 360 cctggggccc agcagttacc ccaggcctct gacctaccct cagtacagcc ccccacaacc 420 ccggccagga gtcatccggg ccctggggcc gcctccaggg gtacgtcgaa ggccttgtga 480 acagatcagc ccggaggaag aggagcgccg ccgagtaagg cgcgagcgga acaagctggc 540 tgcggccaag tgcaggaacc ggaggaagga actgaccgac ttcctgcagg cggagactga 600 caaactggaa gatgagaaat ctgggctgca gcgagagatt gaggagctgc agaagcagaa 660 ggagcgccta gagctggtgc tggaagccca ccgacccatc tgcaaaatcc cggaaggagc 720 caaggagggg gacacaggca gtaccagtgg caccagcagc ccaccagccc cctgccgccc 780 tgtaccttgt atctcccttt ccccagggcc tgtgcttgaa cctgaggcac tgcacacccc 840 cacactcatg accacaccct ccctaactcc tttcaccccc agcctggtct tcacctaccc 900 cagcactcct gagccttgtg cctcagctca tcgcaagagt agcagcagca gcggagaccc 960 atcctctgac ccccttggct ctccaaccct cctcgctttg tgaggcgcct gagccctact 1020 ccctgcagat gccaccctag ccaatgtctc ctccccttcc cccaccggtc cagctggcct 1080 ggacagtatc ccacatccaa ctccagcaac ttcttctcca tccctctaat gagactgacc 1140 atattgtgct tcacagtaga gccagcttgg ggccaccaaa gctgcccact gtttctcttg 1200 agctggcctc tctagcacaa tttgcactaa atcagagaca aaatatttcc catttgtgcc 1260 agaggaatcc tggcagccca gagactttgt agatccttag aggtcctctg gagccctaac 1320 cccttccaga tcactgccac actctccatc accctcttcc tgtgatccac ccaaccctat 1380 ctcctgacag aaggtgccac tttacccacc tagaacacta actcaccagc cccactgcca 1440 gcagcagcag gtgattggac caggccattc tgccgccccc tcctgaaccg cacagctcag 1500 gaggcgccct tggcttctgt gatgagctga tctgcggatc tcagctttga gaagccttca 1560 gctccaggga atccaagcct ccacagcgag ggcagctgct atttattttc ctaaagagag 1620 tatttttata caaacctacc aaaatggaat aaaaggcttg aagctgtggc ctgagtgcct 1680 cactggaccc agaggccaat gggagagtat ttggagccct aggtcccagc cttagctcta 1740 cagactcact gcaaaaaaa 1759 <210> 214 <211> 2098 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2098) <223> FST mRNA <400> 214 ttgggaaggg tttccagaag gtgggaaatg tcacctgatt cacactgaac ttttgaaagc 60 tccccacccc caaggagccg cgcacaccct cgctcgcggc cgccctccca cagccccaca 120 cactgggaga ccgcccaccg caaaccgcgg agacccccgt ctagatttaa agcgcggctg 180 cgcccggctt ctgacgtcca ttgaatcgcg cgggcggccg gcggcgagcg cggggctgcg 240 ccgggatcgc tgcgccctcc gccgctggcc tctgcgacgc gcgccgctcg cccgagccac 300 ccgccgccgc gccggctccc cgcgccgctg cgctcctcgc cccgcgcctg cccccaggat 360 ggtccgcgcg aggcaccagc cgggtgggct ttgcctcctg ctgctgctgc tctgccagtt 420 catggaggac cgcagtgccc aggctgggaa ctgctggctc cgtcaagcga agaacggccg 480 ctgccaggtc ctgtacaaga ccgaactgag caaggaggag tgctgcagca ccggccggct 540 gagcacctcg tggaccgagg aggacgtgaa tgacaacaca ctcttcaagt ggatgatttt 600 caacgggggc gcccccaact gcatcccctg taaagaaacg tgtgagaacg tggactgtgg 660 acctgggaaa aaatgccgaa tgaacaagaa gaacaaaccc cgctgcgtct gcgccccgga 720 ttgttccaac atcacctgga agggtccagt ctgcgggctg gatgggaaaa cctaccgcaa 780 tgaatgtgca ctcctaaagg caagatgtaa agagcagcca gaactggaag tccagtacca 840 aggcagatgt aaaaagactt gtcgggatgt tttctgtcca ggcagctcca catgtgtggt 900 ggaccagacc aataatgcct actgtgtgac ctgtaatcgg atttgcccag agcctgcttc 960 ctctgagcaa tatctctgtg ggaatgatgg agtcacctac tccagtgcct gccacctgag 1020 aaaggctacc tgcctgctgg gcagatctat tggattagcc tatgagggaa agtgtatcaa 1080 agcaaagtcc tgtgaagata tccagtgcac tggtgggaaa aaatgtttat gggatttcaa 1140 ggttgggaga ggccggtgtt ccctctgtga tgagctgtgc cctgacagta agtcggatga 1200 gcctgtctgt gccagtgaca atgccactta tgccagcgag tgtgccatga aggaagctgc 1260 ctgctcctca ggtgtgctac tggaagtaaa gcactccgga tcttgcaact gaatctgccc 1320 gtaaaacctg agccattgat tcttcagaac tttctgcagt ttttgacttc atagattatg 1380 ctttaaaaaa atttttttaa cttattgcat aacagcagat gccaaaaaca aaaaaagcat 1440 ctcactgcaa gtcacataaa aatgcaacgc tgtaatatgg ctgtatcaga gggctttgaa 1500 aacatacact gagctgcttc tgcgctgttg ttgtccgtat ttaaacaaca gctcccctgt 1560 attcccccat ctagccattt cggaagacac cgaggaagag gaggaagatg aagaccagga 1620 ctacagcttt cctatatctt ctattctaga gtggtaaact ctctataagt gttcagtgtt 1680 gacatagcct ttgtgcaaaa aaaaaaaaaa aaaaaaagaa aaagaaaaaa agaaaaatat 1740 attgtccata ctgtaaataa gtgtatgctt atttatttgg ggggaaaact atacattaaa 1800 ggacctttgt cctaaagctc tctcccaggc caccttgtta ctcattggac acggagaggc 1860 attcattgtg aggtctactg gatgaggccc atagttgaga cttgtagaca tttatttata 1920 ctgtgtcatg ttttataatt tatacataaa atgtctggtt gactgtatac cttgtttttg 1980 aagaaattta ttcgtgaaag gaagagcagt tgttatttat tgtgaggtct cttgcttgta 2040 aagtaaaagc tttttttcct tgtaaaccat ttaagtccat tccttactat tcactcac 2098 <210> 215 <211> 3275 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3275) <223> HAS2 mRNA <400> 215 gaagtcaaga cgtctggaaa gaattaccca gtcctggctt cgagcagccc attgaaccag 60 agacttgaaa cagccccagc caaagacttt tctcccaatt ctgcgcttcc tgggttctgc 120 tgagtcttcc acaggctttt tttttttttt tttttttttt taagacgaaa aagagatttt 180 ctgttatcgg gggcagaaag actgaagccc aaaaaaaaaa aaaaaaaaaa aagaaaagaa 240 aagaaaaaag aaaagttaat ttatttttaa agcataattt ttttaagaat tagactgaag 300 tgcaacggaa acataaagag aatattagtg aaattatttt ttaaagtggg gaagaatcaa 360 acatttaaga ctcccctatc ctttttaaat gttgttttta aatttcttat tttttttggc 420 cggtcgtctc aaattcatct gatctcttat tacctcaatt ttggaaactg cccgccaccg 480 accctccggg accacacaga caggctgagg acgactttat gaccaagagc tgaacaagat 540 gcattgtgag aggtttctat gtatcctgag aataattgga accacactct ttggagtctc 600 tctcctcctt ggaatcacag ctgcttatat tgttggctac cagtttatcc aaacggataa 660 ttactatttc tcttttggac tgtatggtgc ctttttggca tcacacctca tcatccaaag 720 cctgtttgcc tttttggagc accgaaaaat gaaaaaatcc ctagaaaccc ccataaagtt 780 gaacaaaaca gttgcccttt gcatcgctgc ctatcaagaa gatccagact acttaaggaa 840 atgtttgcaa tctgtgaaaa ggctaaccta ccctgggatt aaagttgtca tggtcataga 900 tgggaactca gaagatgacc tttacatgat ggacatcttc agtgaagtca tgggcagaga 960 caaatcagcc acttatatct ggaagaacaa cttccacgaa aagggtcccg gtgagacaga 1020 tgagtcacat aaagaaagct cgcaacacgt aacgcaattg gtcttgtcca acaaaagtat 1080 ctgcatcatg caaaaatggg gtggaaaaag agaagtcatg tacacagcct tcagagcact 1140 gggacgaagt gtggattatg tacaggtttg tgattcagac actatgcttg acccagcctc 1200 atctgtggag atggtaaaag ttttagaaga agatcccatg gttggaggtg ttgggggaga 1260 tgtccagatt ttaaacaagt acgattcctg gatctcattc ctcagcagtg taagatattg 1320 gatggctttt aatatagaaa gggcctgtca gtcttatttt gggtgtgttc agtgcattag 1380 tggacctctg ggaatgtaca gaaactcctt gttgcatgag tttgtggaag attggtacaa 1440 tcaagaattt atgggcaacc aatgtagctt tggtgatgac aggcatctca cgaaccgggt 1500 gctgagcctg ggctatgcaa caaaatacac agctcgatct aagtgcctta ctgaaacacc 1560 tatagaatat ctcagatggc taaaccagca gacccgttgg agcaagtcct acttccgaga 1620 atggctgtac aatgcaatgt ggtttcacaa acatcacttg tggatgacct acgaagcgat 1680 tatcactgga ttctttcctt tctttctcat tgccacagta atccagctct tctaccgggg 1740 taaaatttgg aacattctcc tcttcttgtt aactgtccag ctagtaggtc tcataaaatc 1800 atcttttgcc agctgcctta gaggaaatat cgtcatggtc ttcatgtctc tctactcagt 1860 gttatacatg tcgagtttac ttcccgccaa gatgtttgca attgcaacaa taaacaaagc 1920 tgggtggggc acatcaggaa ggaaaaccat tgttgttaat ttcataggac tcattccagt 1980 atcagtttgg tttacaatcc tcctgggtgg tgtgattttc accatttata aggagtctaa 2040 aaggccattt tcagaatcca aacagacagt tctaattgtt ggaacgttgc tctatgcatg 2100 ctattgggtc atgcttttga cgctgtatgt agttctcatc aataagtgtg gcaggcggaa 2160 gaagggacaa caatatgaca tggtgcttga tgtatgatct tccatgtttt gacgtttgca 2220 gtcacacaca acaccttagt tcctctaggg gctgtacagt attgtggcat cagataatgc 2280 caccaaagga gacatatcac tgctgctggg acttgaacaa agacatttat atgggtttat 2340 tttcattctg ccaaagtaaa acaatacatc aacaagaaga aactcagatt taacctgtta 2400 tttctatgaa aatgggatga attctttgtt tatgcacttt ttccttactg tgcatccgcc 2460 tgaaagtgtt ttgccctata tacctcacta gccatgcttt atgtgggtta tcatggaaga 2520 aaaggatttt ggaaactcaa ggaaaagttc tttcaaccta tacaacctaa cttatggact 2580 gttttgatag atgataattt ttttttttta ggaaggattt tctttttaac tttaccaaat 2640 gaaatgccaa aggaagtttt aaaggccgtt ggctgtgctg tattttgata taattgtact 2700 gtgtttttaa attttgtatg ccaatcttaa agacaaattt tgcatattct ctattttact 2760 tttctgccaa aataaacctg ttcttccttt tttaaaataa aataagttct taaaaaattt 2820 atacttaaaa aatcctgccc aaaatgtgaa gcttggttga ctgatgttca tgatagaaag 2880 aataaaatgt ttctctctct ctacctttta aaattgaata gtttatttct gtgaaagaag 2940 tatttaaact ttcaatattt taactttttg tttttatttc ttttagaaaa ggccaatata 3000 cctatcacac tttggaagta aaaatacaca ctttcgtgtg tacctaaaaa aaaaatcgtt 3060 gaaaatcaag gccaaaggta gtgcaatttt ttcattaaga tttaaaaaaa agggaatgat 3120 agtctttgaa agaaaacagt aggcatccag cactggacaa aacatgggta tcaaagatga 3180 ataatctttg gagattctgg cagtgttttc ccagaacaag tcaagtggaa agtggagaaa 3240 ttatctgtat aattttggac acatacaatg cagtt 3275 <210> 216 <211> 2381 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2381) <223> HBEGF mRNA <400> 216 attcggccga aggagctacg cgggccacgc tgctggctgg cctgacctag gcgcgcgggg 60 tcgggcggcc gcgcgggcgg gctgagtgag caagacaaga cactcaagaa gagcgagctg 120 cgcctgggtc ccggccaggc ttgcacgcag aggcgggcgg cagacggtgc ccggcggaat 180 ctcctgagct ccgccgccca gctctggtgc cagcgcccag tggccgccgc ttcgaaagtg 240 actggtgcct cgccgcctcc tctcggtgcg ggaccatgaa gctgctgccg tcggtggtgc 300 tgaagctctt tctggctgca gttctctcgg cactggtgac tggcgagagc ctggagcggc 360 ttcggagagg gctagctgct ggaaccagca acccggaccc tcccactgta tccacggacc 420 agctgctacc cctaggaggc ggccgggacc ggaaagtccg tgacttgcaa gaggcagatc 480 tggacctttt gagagtcact ttatcctcca agccacaagc actggccaca ccaaacaagg 540 aggagcacgg gaaaagaaag aagaaaggca aggggctagg gaagaagagg gacccatgtc 600 ttcggaaata caaggacttc tgcatccatg gagaatgcaa atatgtgaag gagctccggg 660 ctccctcctg catctgccac ccgggttacc atggagagag gtgtcatggg ctgagcctcc 720 cagtggaaaa tcgcttatat acctatgacc acacaaccat cctggccgtg gtggctgtgg 780 tgctgtcatc tgtctgtctg ctggtcatcg tggggcttct catgtttagg taccatagga 840 gaggaggtta tgatgtggaa aatgaagaga aagtgaagtt gggcatgact aattcccact 900 gagagagact tgtgctcaag gaatcggctg gggactgcta cctctgagaa gacacaaggt 960 gatttcagac tgcagagggg aaagacttcc atctagtcac aaagactcct tcgtccccag 1020 ttgccgtcta ggattgggcc tcccataatt gctttgccaa aataccagag ccttcaagtg 1080 ccaaacagag tatgtccgat ggtatctggg taagaagaaa gcaaaagcaa gggaccttca 1140 tgcccttctg attcccctcc accaaacccc acttcccctc ataagtttgt ttaaacactt 1200 atcttctgga ttagaatgcc ggttaaattc catatgctcc aggatctttg actgaaaaaa 1260 aaaaagaaga agaagaagga gagcaagaag gaaagatttg tgaactggaa gaaagcaaca 1320 aagattgaga agccatgtac tcaagtacca ccaagggatc tgccattggg accctccagt 1380 gctggatttg atgagttaac tgtgaaatac cacaagcctg agaactgaat tttgggactt 1440 ctacccagat ggaaaaataa caactatttt tgttgttgtt gtttgtaaat gcctcttaaa 1500 ttatatattt attttattct atgtatgtta atttatttag tttttaacaa tctaacaata 1560 atatttcaag tgcctagact gttactttgg caatttcctg gccctccact cctcatcccc 1620 acaatctggc ttagtgccac ccacctttgc cacaaagcta ggatggttct gtgacccatc 1680 tgtagtaatt tattgtctgt ctacatttct gcagatcttc cgtggtcaga gtgccactgc 1740 gggagctctg tatggtcagg atgtaggggt taacttggtc agagccactc tatgagttgg 1800 acttcagtct tgcctaggcg attttgtcta ccatttgtgt tttgaaagcc caaggtgctg 1860 atgtcaaagt gtaacagata tcagtgtctc cccgtgtcct ctccctgcca agtctcagaa 1920 gaggttgggc ttccatgcct gtagctttcc tggtccctca cccccatggc cccaggccca 1980 cagcgtggga actcactttc ccttgtgtca agacatttct ctaactcctg ccattcttct 2040 ggtgctactc catgcagggg tcagtgcagc agaggacagt ctggagaagg tattagcaaa 2100 gcaaaaggct gagaaggaac agggaacatt ggagctgact gttcttggta actgattacc 2160 tgccaattgc taccgagaag gttggaggtg gggaaggctt tgtataatcc cacccacctc 2220 accaaaacga tgaagttatg ctgtcatggt cctttctgga agtttctggt gccatttctg 2280 aactgttaca acttgtattt ccaaacctgg ttcatattta tactttgcaa tccaaataaa 2340 gataaccctt attccataaa aaaaaaaaaa aaaaaaaaaa a 2381 <210> 217 <211> 5834 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(5834) <223> HGF mRNA <400> 217 aggcactgac tccgaacagg attctttcac ccaggcatct cctccagagg gatccgccag 60 cccgtccagc agcaccatgt gggtgaccaa actcctgcca gccctgctgc tgcagcatgt 120 cctcctgcat ctcctcctgc tccccatcgc catcccctat gcagagggac aaaggaaaag 180 aagaaataca attcatgaat tcaaaaaatc agcaaagact accctaatca aaatagatcc 240 agcactgaag ataaaaacca aaaaagtgaa tactgcagac caatgtgcta atagatgtac 300 taggaataaa ggacttccat tcacttgcaa ggcttttgtt tttgataaag caagaaaaca 360 atgcctctgg ttccccttca atagcatgtc aagtggagtg aaaaaagaat ttggccatga 420 atttgacctc tatgaaaaca aagactacat tagaaactgc atcattggta aaggacgcag 480 ctacaaggga acagtatcta tcactaagag tggcatcaaa tgtcagccct ggagttccat 540 gataccacac gaacacagct ttttgccttc gagctatcgg ggtaaagacc tacaggaaaa 600 ctactgtcga aatcctcgag gggaagaagg gggaccctgg tgtttcacaa gcaatccaga 660 ggtacgctac gaagtctgtg acattcctca gtgttcagaa gttgaatgca tgacctgcaa 720 tggggagagt tatcgaggtc tcatggatca tacagaatca ggcaagattt gtcagcgctg 780 ggatcatcag acaccacacc ggcacaaatt cttgcctgaa agatatcccg acaagggctt 840 tgatgataat tattgccgca atcccgatgg ccagccgagg ccatggtgct atactcttga 900 ccctcacacc cgctgggagt actgtgcaat taaaacatgc gctgacaata ctatgaatga 960 cactgatgtt cctttggaaa caactgaatg catccaaggt caaggagaag gctacagggg 1020 cactgtcaat accatttgga atggaattcc atgtcagcgt tgggattctc agtatcctca 1080 cgagcatgac atgactcctg aaaatttcaa gtgcaaggac ctacgagaaa attactgccg 1140 aaatccagat gggtctgaat caccctggtg ttttaccact gatccaaaca tccgagttgg 1200 ctactgctcc caaattccaa actgtgatat gtcacatgga caagattgtt atcgtgggaa 1260 tggcaaaaat tatatgggca acttatccca aacaagatct ggactaacat gttcaatgtg 1320 ggacaagaac atggaagact tacatcgtca tatcttctgg gaaccagatg caagtaagct 1380 gaatgagaat tactgccgaa atccagatga tgatgctcat ggaccctggt gctacacggg 1440 aaatccactc attccttggg attattgccc tatttctcgt tgtgaaggtg ataccacacc 1500 tacaatagtc aatttagacc atcccgtaat atcttgtgcc aaaacgaaac aattgcgagt 1560 tgtaaatggg attccaacac gaacaaacat aggatggatg gttagtttga gatacagaaa 1620 taaacatatc tgcggaggat cattgataaa ggagagttgg gttcttactg cacgacagtg 1680 tttcccttct cgagacttga aagattatga agcttggctt ggaattcatg atgtccacgg 1740 aagaggagat gagaaatgca aacaggttct caatgtttcc cagctggtat atggccctga 1800 aggatcagat ctggttttaa tgaagcttgc caggcctgct gtcctggatg attttgttag 1860 tacgattgat ttacctaatt atggatgcac aattcctgaa aagaccagtt gcagtgttta 1920 tggctggggc tacactggat tgatcaacta tgatggccta ttacgagtgg cacatctcta 1980 tataatggga aatgagaaat gcagccagca tcatcgaggg aaggtgactc tgaatgagtc 2040 tgaaatatgt gctggggctg aaaagattgg atcaggacca tgtgaggggg attatggtgg 2100 cccacttgtt tgtgagcaac ataaaatgag aatggttctt ggtgtcattg ttcctggtcg 2160 tggatgtgcc attccaaatc gtcctggtat ttttgtccga gtagcatatt atgcaaaatg 2220 gatacacaaa attattttaa catataaggt accacagtca tagctgaagt aagtgtgtct 2280 gaagcaccca ccaatacaac tgtcttttac atgaagattt cagagaatgt ggaatttaaa 2340 atgtcactta caacaatcct aagacaacta ctggagagtc atgtttgttg aaattctcat 2400 taatgtttat gggtgttttc tgttgttttg tttgtcagtg ttattttgtc aatgttgaag 2460 tgaattaagg tacatgcaag tgtaataaca tatctcctga agatacttga atggattaaa 2520 aaaacacaca ggtatatttg ctggatgata aagatttcat gggaaaaaaa atcaattaat 2580 ctgtctaagc tgctttctga tgttggtttc ttaataatga gtaaaccaca aattaaatgt 2640 tattttaacc tcaccaaaac aatttatacc ttgtgtccct aaattgtagc cctatattaa 2700 attatattac atttcatatg ctatatgtta tagttcattc atttctcttc accatgtatc 2760 ctgcaatact ggtacacgaa cacacttttt acaaaaccac atacccatgt acacatgcct 2820 aggtacacat gtgcatgcac tacagtttaa attatggtgt acctaatgta acccctaaat 2880 attttagaag tatgtaccta tagttttacc tcaaaaaaac cagaaatctc taaagaccag 2940 tagaaatatt aaaaaatgat gcaagatcaa aatgattagc taattctcca tacataatct 3000 gcagatgatc ttctttggtt ggcatttcag gtgtggccat cacccagagt taaataacac 3060 ctaatctagg tgtttacatg tattcattat cctagttatt tcatgtagtt tctaattctt 3120 aaaggaaaga gggtaatagt tctatttgtg taatttgttt cctccaaact taaggccact 3180 tatttacaca agatatttgt agatctattt tcctaaagca tttcttaagt gctcagatca 3240 gtatctaatt gaagaagttt aaaagtgttt tggtcattaa aaatgtactt aaataggtta 3300 aatctaagcc ttgctgctgt gattggcttc tagctcactg cctttaaatt ttaaaaaatt 3360 taagaggaaa atttccaagt ctccaaagtt ttataaatac ccttcatcaa gtcatgcatt 3420 aaagtatata ttggagaaaa aaataaaaat acttttctca acctggaaga ttttagccta 3480 ataaagcttt tttgaagtaa aagacaactt gtaaaaggaa agaaactagt ttgtctcaac 3540 tctgtattca tttatttttt ttttgaagta gagtggaatc tgttgaatca gatattttat 3600 caagatatgt ttattttttc ttatttcatt ttacaaagtt cactcctaat gccatatgta 3660 acagacattt aaattttgtg ttctgtataa cagccaaatt atcatattta tcattgtatt 3720 tgtcatgctt agctaaagat catgtatttg ttgagaaata gaataacaaa aagtaatagg 3780 ataggctttg aatttttgca gaaatcttcc tgtacaaaac acctttaaaa ataatttttt 3840 gaatggtgtg aatccagtag tcccatttct ctgacttagt tttcttgagt gatttttatc 3900 aaggccaagt ccccaaacaa ttccctacca gctctttaga gtactgttca atctggacta 3960 aaatggtttt aagtttatgg agagcttagt ccacagaata tagggcggcg agtccagaaa 4020 tgcttataca attttttttt cataataaga tatgtgctgg catcaagaaa cttaaagtgg 4080 aagcaaaaag acatccaact agttgctggt ctctatcatc ttatctgatg gtatttctat 4140 tttccttata taatacacca ttttagtaag aactcctaga aatttcaaga gcatattgcc 4200 aaaatataaa gtatatttca tagtttcttc tggctgaacc agtgaaattt tattattgca 4260 tattaatgat atttgtaaaa cttttataaa aattgtcata attttaaata ctcacatttt 4320 aaaaatactt ctttaatgac tcttcctcta aatttcctgg aaatacagat aaagattagc 4380 tagatacaag atacagctaa gtatttagac attttgaggc tagtattttt cattttatta 4440 aaggctaaaa acaataccac caataaatca tcaaacaaac cgtacaaagt aattctctct 4500 ttgggaggct cctttcgtga tagagggaca tgggtggaat tgacaatgaa acttagatga 4560 acaaggtcca tgttatttta ggtggtagaa cagggtagag tcatgtcatt atttgctggt 4620 ggaagacact atttaccagg tgttctttgc tgaataaatc attaaacatt tttaaaaatc 4680 caacaatcca ctttattttg tgtcattgac aaaaggatct tttaaatcag aaggtttcaa 4740 tgcaattttt ggtttggctg tttgaataat ggttatgtac tgttataatt gtagacattt 4800 tctcacgtct accaggaatt gaagtgtaaa actaaaatat ttttcataat gcctctgccg 4860 tgcagaagga atgataatcc ttttgtatac ttctttaatt ttattgtaaa atgtgtaatg 4920 acttttacct atatgctgtg ggcaggtcct cagtaaaatc tattgagtca atttctagta 4980 ttaacaggct tttgcttgct atctaagtgt ttcaaattat gggaagtgtg agacactgga 5040 aggcaagaaa attaacaata atggcatgtg atagcaaaat tgtatttcac ttattcctgt 5100 gaatatttct tgttggtacc aatggtactg tacaaagtga atgttatagc cacaacattc 5160 tcttgaaaag aacactgtca agaagtggga aattgctgtc aggcatttca ttgttgtttt 5220 taaacttttt taaaagaaat actggttttg caatatagag atcatgtggt aaagaatttt 5280 aataagatct tatactaaaa agccttaaat caatttattg agattcaaaa aatactatta 5340 taattaatta catcccatac atataggcaa actcatttaa aaaataaaac taattttggt 5400 aaaagtacat ggcctttgtt tttaaaatac ataattttaa aataaatcac ttgtcatgat 5460 aaagtccaaa aagaagttat cattcaacat tcaactaagg ttggagctaa gaatttacta 5520 atacaaaaaa agttaaaatt ttttggacca tatatatctt gacagtgtaa cttttaagta 5580 ggttcatttc catttgcaca gaaagtttct gtctttagga aactgaaaat gaaatactgt 5640 ggatgctatg actgtttgtc ttgtatgtaa ataggaaatt aataagctgc ctattgagtg 5700 gtatagctgt atgcttaccc aaaaaaggga acactgtggt tatgacttgt attataaact 5760 ttctgtagtt aataaagttg ttatttttat aaccatgatt atattattat tattaataaa 5820 atattttatc aaaa 5834 <210> 218 <211> 4150 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4150) <223> HMGA2 mRNA <400> 218 cttgaatctt ggggcaggaa ctcagaaaac ttccagcccg ggcagcgcgc gcttggtgca 60 agactcagga gctagcagcc cgtccccctc cgactctccg gtgccgccgc tgcctgctcc 120 cgccacccta ggaggcgcgg tgccacccac tactctgtcc tctgcctgtg ctccgtgccc 180 gaccctatcc cggcggagtc tccccatcct cctttgcttt ccgactgccc aaggcacttt 240 caatctcaat ctcttctctc tctctctctc tctctctctc tctctctct tctctctctc 300 tctctctctc gcagggtggg gggaagagga ggaggaattc tttccccgcc taacatttca 360 agggacacaa ttcactccaa gtctcttccc tttccaagcc gcttccgaag tgctcccggt 420 gcccgcaact cctgatccca acccgcgaga ggagcctctg cgacctcaaa gcctctcttc 480 cttctccctc gcttccctcc tcctcttgct acctccacct ccaccgccac ctccacctcc 540 ggcacccacc caccgccgcc gccgccaccg gcagcgcctc ctcctctcct cctcctcctc 600 ccctcttctc tttttggcag ccgctggacg tccggtgttg atggtggcag cggcggcagc 660 ctaagcaaca gcagccctcg cagcccgcca gctcgcgctc gccccgccgg cgtccccagc 720 cctatcacct catctcccga aaggtgctgg gcagctccgg ggcggtcgag gcgaagcggc 780 tgcagcggcg gtagcggcgg cgggaggcag gatgagcgca cgcggtgagg gcgcggggca 840 gccgtccact tcagcccagg gacaacctgc cgccccagcg cctcagaaga gaggacgcgg 900 ccgccccagg aagcagcagc aagaaccaac cggtgagccc tctcctaaga gacccagggg 960 aagacccaaa ggcagcaaaa acaagagtcc ctctaaagca gctcaaaaga aagcagaagc 1020 cactggagaa aaacggccaa gaggcagacc taggaaatgg ccacaacaag ttgttcagaa 1080 gaagcctgct caggaggaaa ctgaagagac atcctcacaa gagtctgccg aagaggacta 1140 gggggcgcca acgttcgatt tctacctcag cagcagttgg atcttttgaa gggagaagac 1200 actgcagtga ccacttattc tgtattgcca tggtctttcc actttcatct ggggtggggt 1260 ggggtggggt gggggagggg ggggtggggt ggggagaaat cacataacct taaaaaggac 1320 tatattaatc accttctttg taatcccttc acagtcccag gtttagtgaa aaactgctgt 1380 aaacacaggg gacacagctt aacaatgcaa cttttaatta ctgttttctt ttttcttaac 1440 ctactaatag tttgttgatc tgataagcaa gagtgggcgg gtgagaaaaa ccgaattggg 1500 tttagtcaat cactgcactg catgcaaaca agaaacgtgt cacacttgtg acgtcgggca 1560 ttcatatagg aagaacgcgg tgtgtaacac tgtgtacacc tcaaatacca ccccaaccca 1620 ctccctgtag tgaatcctct gtttagaaca ccaaagataa ggactagata ctactttctc 1680 tttttcgtat aatcttgtag acacttactt gatgattttt aactttttat ttctaaatga 1740 gacgaaatgc tgatgtatcc tttcattcag ctaacaaact agaaaaggtt atgttcattt 1800 ttcaaaaagg gaagtaagca aacaaatatt gccaactctt ctatttatgg atatcacaca 1860 tatcagcagg agtaataaat ttactcacag cacttgtttt caggacaaca cttcattttc 1920 aggaaatcta cttcctacag agccaaaatg ccatttagca ataaataaca cttgtcagcc 1980 tcagagcatt taaggaaact agacaagtaa aattatcctc tttgtaattt aatgaaaagg 2040 tacaacagaa taatgcatga tgaactcacc taattatgag gtgggaggag cgaaatctaa 2100 atttcttttg ctatagttat acatcaattt aaaaagcaaa aaaaaaaaag gggggggcaa 2160 tctctctctg tgtctttctc tctctctctt cctctccctc tctcttttca ttgtgtatca 2220 gtttccatga aagacctgaa taccacttac ctcaaattaa gcatatgtgt tacttcaagt 2280 aatacgtttt gacataagat ggttgaccaa ggtgcttttc ttcggcttga gttcaccatc 2340 tcttcattca aactgcactt ttagccagag atgcaatata tccccactac tcaatactac 2400 ctctgaatgt tacaacgaat ttacagtcta gtacttatta catgctgcta tacacaagca 2460 atgcaagaaa aaaacttact gggtaggtga ttctaatcat ctgcagttct ttttgtacac 2520 ttaattacag ttaaagaagc aatctcctta ctgtgtttca gcatgactat gtatttttct 2580 atgttttttt aattaaaaat ttttaaaata cttgtttcag cttctctgct agatttctac 2640 attaacttga aaatttttta accaagtcgc tcctaggttc ttaaggataa ttttcctcaa 2700 tcacactaca catcacacaa gatttgactg taatatttaa atattaccct ccaagtctgt 2760 acctcaaatg aattctttaa ggagatggac taattgactt gcaaagacct acctccagac 2820 ttcaaaagga atgaacttgt tacttgcagc attcatttgt tttttcaatg tttgaaatag 2880 ttcaaactgc agctaaccct agtcaaaact atttttgtaa aagacatttg atagaaagga 2940 acacgttttt acatactttt gcaaaataag taaataataa ataaaataaa agccaacctt 3000 caaagaaact tgaagctttg taggtgagat gcaacaagcc ctgcttttgc ataatgcaat 3060 caaaaatatg tgtttttaag attagttgaa tataagaaaa tgcttgacaa atattttcat 3120 gtattttaca caaatgtgat ttttgtaata tgtctcaacc agatttattt taaacgcttc 3180 ttatgtagag tttttatgcc tttctctcct agtgagtgtg ctgacttttt aacatggtat 3240 tatcaactgg gccaggaggt agtttctcat gacggctttt gtcagtatgg cttttagtac 3300 tgaagccaaa tgaaactcaa aaccatctct cttccagctg cttcagggag gtagtttcaa 3360 aggccacata cctctctgag actggcagat cgctcactgt tgtgaatcac caaaggagct 3420 atggagagaa ttaaaactca acattactgt taactgtgcg ttaaataagc aaataaacag 3480 tggctcataa aaataaaagt cgcattccat atctttggat gggcctttta gaaacctcat 3540 tggccagctc ataaaatgga agcaattgct catgttggcc aaacatggtg caccgagtga 3600 tttccatctc tggtaaagtt acacttttat ttcctgtatg ttgtacaatc aaaacacact 3660 actacctctt aagtcccagt atacctcatt tttcatactg aaaaaaaaag cttgtggcca 3720 atggaacagt aagaacatca taaaattttt atatatatag tttatttttg tgggagataa 3780 attttatagg actgttcttt gctgttgttg gtcgcagcta cataagactg gacatttaac 3840 ttttctacca tttctgcaag ttaggtatgt ttgcaggaga aaagtatcaa gacgtttaac 3900 tgcagttgac tttctccctg ttcctttgag tgtcttctaa ctttattctt tgttctttat 3960 gtagaattgc tgtctatgat tgtactttga atcgcttgct tgttgaaaat atttctctag 4020 tgtattatca ctgtctgttc tgcacaataa acataacagc ctctgtgatc cccatgtgtt 4080 ttgattcctg ctctttgtta cagttccatt aaatgagtaa taaagtttgg tcaaaacaga 4140 aaaaaaaaaa 4150 <210> 219 <211> 2967 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2967) <223> ICAM1 mRNA <400> 219 gagctcctct gctactcaga gttgcaacct cagcctcgct atggctccca gcagcccccg 60 gcccgcgctg cccgcactcc tggtcctgct cggggctctg ttcccaggac ctggcaatgc 120 ccagacatct gtgtccccct caaaagtcat cctgccccgg ggaggctccg tgctggtgac 180 atgcagcacc tcctgtgacc agcccaagtt gttgggcata gagaccccgt tgcctaaaaa 240 ggagttgctc ctgcctggga acaaccggaa ggtgtatgaa ctgagcaatg tgcaagaaga 300 tagccaacca atgtgctatt caaactgccc tgatgggcag tcaacagcta aaaccttcct 360 caccgtgtac tggactccag aacgggtgga actggcaccc ctcccctctt ggcagccagt 420 gggcaagaac cttaccctac gctgccaggt ggagggtggg gcaccccggg ccaacctcac 480 cgtggtgctg ctccgtgggg agaaggagct gaaacgggag ccagctgtgg gggagcccgc 540 tgaggtcacg accacggtgc tggtgaggag agatcaccat ggagccaatt tctcgtgccg 600 cactgaactg gacctgcggc cccaagggct ggagctgttt gagaacacct cggcccccta 660 ccagctccag acctttgtcc tgccagcgac tcccccacaa cttgtcagcc cccgggtcct 720 agaggtggac acgcagggga ccgtggtctg ttccctggac gggctgttcc cagtctcgga 780 ggcccaggtc cacctggcac tgggggacca gaggttgaac cccacagtca cctatggcaa 840 cgactccttc tcggccaagg cctcagtcag tgtgaccgca gaggacgagg gcacccagcg 900 gctgacgtgt gcagtaatac tggggaacca gagccaggag acactgcaga cagtgaccat 960 ctacagcttt ccggcgccca acgtgattct gacgaagcca gaggtctcag aagggaccga 1020 ggtgacagtg aagtgtgagg cccaccctag agccaaggtg acgctgaatg gggttccagc 1080 ccagccactg ggcccgaggg cccagctcct gctgaaggcc accccagagg acaacgggcg 1140 cagcttctcc tgctctgcaa ccctggaggt ggccggccag cttatacaca agaaccagac 1200 ccgggagctt cgtgtcctgt atggcccccg actggacgag agggattgtc cgggaaactg 1260 gacgtggcca gaaaattccc agcagactcc aatgtgccag gcttggggga acccattgcc 1320 cgagctcaag tgtctaaagg atggcacttt cccactgccc atcggggaat cagtgactgt 1380 cactcgagat cttgagggca cctacctctg tcgggccagg agcactcaag gggaggtcac 1440 ccgcaaggtg accgtgaatg tgctctcccc ccggtatgag attgtcatca tcactgtggt 1500 agcagccgca gtcataatgg gcactgcagg cctcagcacg tacctctata accgccagcg 1560 gaagatcaag aaatacagac tacaacaggc ccaaaaaggg acccccatga aaccgaacac 1620 acaagccacg cctccctgaa cctatcccgg gacagggcct cttcctcggc cttcccatat 1680 tggtggcagt ggtgccacac tgaacagagt ggaagacata tgccatgcag ctacacctac 1740 cggccctggg acgccggagg acagggcatt gtcctcagtc agatacaaca gcatttgggg 1800 ccatggtacc tgcacaccta aaacactagg ccacgcatct gatctgtagt cacatgacta 1860 agccaagagg aaggagcaag actcaagaca tgattgatgg atgttaaagt ctagcctgat 1920 gagaggggaa gtggtggggg agacatagcc ccaccatgag gacatacaac tgggaaatac 1980 tgaaacttgc tgcctattgg gtatgctgag gccccacaga cttacagaag aagtggccct 2040 ccatagacat gtgtagcatc aaaacacaaa ggcccacact tcctgacgga tgccagcttg 2100 ggcactgctg tctactgacc ccaacccttg atgatatgta tttattcatt tgttatttta 2160 ccagctattt attgagtgtc ttttatgtag gctaaatgaa cataggtctc tggcctcacg 2220 gagctcccag tcctaatcac attcaaggtc accaggtaca gttgtacagg ttgtacactg 2280 caggagagtg cctggcaaaa agatcaaatg gggctgggac ttctcattgg ccaacctgcc 2340 tttccccaga aggagtgatt tttctatcgg cacaaaagca ctatatggac tggtaatggt 2400 tacaggttca gagattaccc agtgaggcct tattcctccc ttccccccaa aactgacacc 2460 tttgttagcc acctccccac ccacatacat ttctgccagt gttcacaatg acactcagcg 2520 gtcatgtctg gacatgagtg cccagggaat atgcccaagc tatgccttgt cctcttgtcc 2580 tgtttgcatt tcactgggag cttgcactat gcagctccag tttcctgcag tgatcagggt 2640 cctgcaagca gtggggaagg gggccaaggt attggaggac tccctcccag ctttggaagc 2700 ctcatccgcg tgtgtgtgtg tgtgtatgtg tagacaagct ctcgctctgt cacccaggct 2760 ggagtgcagt ggtgcaatca tggttcactg cagtcttgac cttttgggct caagtgatcc 2820 tcccacctca gcctcctgag tagctgggac cataggctca caacaccaca cctggcaaat 2880 ttgatttttt ttttttttcc agagacgggg tctcgcaaca ttgcccagac ttcctttgtg 2940 ttagttaata aagctttctc aactgcc 2967 <210> 220 <211> 1237 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1237) <223> IER3 mRNA <400> 220 acttggcctt acactccgct cggctcacca tgtgtcactc tcgcagctgc cacccgacca 60 tgaccatcct gcaggccccg accccggccc cctccaccat cccgggaccc cggcggggct 120 ccggtcctga gatcttcacc ttcgaccctc tcccggagcc cgcagcggcc cctgccgggc 180 gccccagcgc ctctcgcggg caccgaaagc gcagccgcag ggttctctac cctcgagtgg 240 tccggcgcca gctgccagtc gaggaaccga acccagccaa aaggcttctc tttctgctgc 300 tcaccatcgt cttctgccag atcctgatgg ctgaagaggg tgtgccggcg cccctgcctc 360 cagaggacgc ccctaacgcc gcatccctgg cgcccacccc tgtgtccgcc gtcctcgagc 420 cctttaatct gacttcggag ccctcggact acgctctgga cctcagcact ttcctccagc 480 aacacccggc cgccttctaa ctgtgactcc ccgcactccc caaaaagaat ccgaaaaacc 540 acaaagaaac accaggcgta cctggtgcgc gagagcgtat ccccaactgg gacttccgag 600 gcaacttgaa ctcagaacac tacagcggag acgccacccg gtgcttgagg cgggaccgag 660 gcgcacagag accgaggcgc atagagaccg aggcacagcc cagctggggc taggcccggt 720 gggaaggaga gcgtcgttaa tttatttctt attgctccta attaatattt atatgtattt 780 atgtacgtcc tcctaggtga tggagatgtg tacgtaatat ttattttaac ttatgcaagg 840 gtgtgagatg ttccccctgc tgtaaatgca ggtctcttgg tatttattga gctttgtggg 900 actggtggaa gcaggacacc tggaactgcg gcaaagtagg agaagaaatg gggaggactc 960 gggtggggga ggacgtcccg gctgggatga agtctggtgg tgggtcgtaa gtttaggagg 1020 tgactgcatc ctccagcatc tcaactccgt ctgtctactg tgtgagactt cggcggacca 1080 ttaggaatga gatccgtgag atccttccat cttcttgaag tcgcctttag ggtggctgcg 1140 aggtagaggg ttgggggttg gtgggctgtc acggagcgac tgtcgagatc gcctagtatg 1200 ttctgtgaac acaaataaaa ttgatttact gtctgca 1237 <210> 221 <211> 1376 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1376) <223> IL-13RA2 mRNA <400> 221 gtaagaacac tctcgtgagt ctaacggtct tccggatgaa ggctatttga agtcgccata 60 acctggtcag aagtgtgcct gtcggcgggg agagaggcaa tatcaaggtt ttaaatctcg 120 gagaaatggc tttcgtttgc ttggctatcg gatgcttata tacctttctg ataagcacaa 180 catttggctg tacttcatct tcagacaccg agataaaagt taaccctcct caggattttg 240 agatagtgga tcccggatac ttaggttatc tctatttgca atggcaaccc ccactgtctc 300 tggatcattt taaggaatgc acagtggaat atgaactaaa ataccgaaac attggtagtg 360 aaacatggaa gaccatcatt actaagaatc tacattacaa agatgggttt gatcttaaca 420 agggcattga agcgaagata cacacgcttt taccatggca atgcacaaat ggatcagaag 480 ttcaaagttc ctgggcagaa actacttatt ggatatcacc acaaggaatt ccagaaacta 540 aagttcagga tatggattgc gtatattaca attggcaata tttactctgt tcttggaaac 600 ctggcatagg tgtacttctt gataccaatt acaacttgtt ttactggtat gagggcttgg 660 atcatgcatt acagtgtgtt gattacatca aggctgatgg acaaaatata ggatgcagat 720 ttccctattt ggaggcatca gactataaag atttctatat ttgtgttaat ggatcatcag 780 agaacaagcc tatcagatcc agttatttca cttttcagct tcaaaatata gttaaacctt 840 tgccgccagt ctatcttact tttactcggg agagttcatg tgaaattaag ctgaaatgga 900 gcataccttt gggacctatt ccagcaaggt gttttgatta tgaaattgag atcagagaag 960 atgatactac cttggtgact gctacagttg aaaatgaaac atacaccttg aaaacaacaa 1020 atgaaacccg acaattatgc tttgtagtaa gaagcaaagt gaatatttat tgctcagatg 1080 acggaatttg gagtgagtgg agtgataaac aatgctggga aggtgaagac ctatcgaaga 1140 aaactttgct acgtttctgg ctaccatttg gtttcatctt aatattagtt atatttgtaa 1200 ccggtctgct tttgcgtaag ccaaacacct acccaaaaat gattccagaa tttttctgtg 1260 atacatgaag actttccata tcaagagaca tggtattgac tcaacagttt ccagtcatgg 1320 ccaaatgttc aatatgagtc tcaataaact gaatttttct tgcgaatgtt gaaaaa 1376 <210> 222 <211> 2718 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2718) <223> IL-33 mRNA <400> 222 agtctacaga ctcctccgaa cacagagctg cagctcttca gggaagaaat caaaacaaga 60 tcacaagaat actgaaaaat gaagcctaaa atgaagtatt caaccaacaa aatttccaca 120 gcaaagtgga agaacacagc aagcaaagcc ttgtgtttca agctgggaaa atcccaacag 180 aaggccaaag aagtttgccc catgtacttt atgaagctcc gctctggcct tatgataaaa 240 aaggaggcct gttactttag gagagaaacc accaaaaggc cttcactgaa aacaggtaga 300 aagcacaaaa gacatctggt actcgctgcc tgtcaacagc agtctactgt ggagtgcttt 360 gcctttggta tatcaggggt ccagaaatat actagagcac ttcatgattc aagtatcaca 420 ggaatttcac ctattacaga gtatcttgct tctctaagca catacaatga tcaatccatt 480 acttttgctt tggaggatga aagttatgag atatatgttg aagacttgaa aaaagatgaa 540 aagaaagata aggtgttact gagttactat gagtctcaac acccctcaaa tgaatcaggt 600 gacggtgttg atggtaagat gttaatggta accctgagtc ctacaaaaga cttctggttg 660 catgccaaca acaaggaaca ctctgtggag ctccataagt gtgaaaaacc actgccagac 720 caggccttct ttgtccttca taatatgcac tccaactgtg tttcatttga atgcaagact 780 gatcctggag tgtttatagg tgtaaaggat aatcatcttg ctctgattaa agtagactct 840 tctgagaatt tgtgtactga aaatatcttg tttaagctct ctgaaactta gttgatggaa 900 acctgtgagt cttgggttga gtacccaaat gctaccactg gagaaggaat gagagataaa 960 gaaagagaca ggtgacatct aagggaaatg aagagtgctt agcatgtgtg gaatgttttc 1020 catattatgt ataaaaatat tttttctaat cctccagtta ttcttttatt tccctctgta 1080 taactgcatc ttcaatacaa gtatcagtat attaaatagg gtattggtaa agaaacggtc 1140 aacattctaa agagatacag tctgaccttt acttttctct agtttcagtc cagaaagaac 1200 ttcatattta gagctaaggc cactgaggaa agagccatag cttaagtctc tatgtagaca 1260 gggatccatt ttaaagagct acttagagaa ataattttcc acagttccaa acgataggct 1320 caaacactag agctgctagt aaaaagaaga ccagatgctt cacagaatta tcattttttc 1380 aactggaata aaacaccagg tttgtttgta gatgtcttag gcaacactca gagcagatct 1440 cccttactgt caggggatat ggaacttcaa aggcccacat ggcaagccag gtaacataaa 1500 tgtgtgaaaa agtaaagata actaaaaaat ttagaaaaat aaatccagta tttgtaaagt 1560 gaataacttc atttctaatt gtttaatttt taaaattctg atttttatat attgagttta 1620 agcaaggcat tcttacacga ggaagtgaag taaattttag ttcagacata aaatttcact 1680 tattaggaat atgtaacatg ctaaaacttt ttttttttta aagagtactg agtcacaaca 1740 tgttttagag catccaagta ccatataatc caactatcat ggtaaggcca gaaatcttct 1800 aacctaccag agcctagatg agacaccgaa ttaacattaa aatttcagta actgactgtc 1860 cctcatgtcc atggcctacc atcccttctg accctggctt ccagggacct atgtctttta 1920 atactcactg tcacattggg caaagttgct tctaatcctt atttcccatg tgcacaagtc 1980 tttttgtatt ccagcttcct gataacactg cttactgtgg aatattcatt tgacatctgt 2040 ctcttttcat ttcttttaac taccatgccc ttgatatatc ttttgcacct gctgaacttc 2100 atttctgtat cacctgacct ctggatgcca aaacgtttat tctgctttgt ctgttgtaga 2160 attttagata aagctattaa tggcaatatt tttttgctaa acgtttttgt tttttactgt 2220 cactagggca ataaaattta tactcaacca tataataaca ttttttaact actaaaggag 2280 tagtttttat tttaaagtct tagcaatttc tattacaact tttcttagac ttaacactta 2340 tgataaatga ctaacatagt aacagaatct ttatgaaata tgaccttttc tgaaaataca 2400 tacttttaca tttctacttt attgagacct attagatgta agtgctagta gaatataaga 2460 taaaagaggc tgagaattac catacaaggg tattacaact gtaaaacaat ttatctttgt 2520 ttcattgttc tgtcaataat tgttaccaaa gagataaaaa taaaagcaga atgtatatca 2580 tcccatctga aaaacactaa ttattgacat gtgcatctgt acaataaact taaaatgatt 2640 attaaataat caaatatatc tactacattg tttatattat tgaataaagt atattttcca 2700 aatgtaaaaa aaaaaaaa 2718 <210> 223 <211> 1498 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1498) <223> IL-1B mRNA <400> 223 accaaacctc ttcgaggcac aaggcacaac aggctgctct gggattctct tcagccaatc 60 ttcattgctc aagtgtctga agcagccatg gcagaagtac ctgagctcgc cagtgaaatg 120 atggcttatt acagtggcaa tgaggatgac ttgttctttg aagctgatgg ccctaaacag 180 atgaagtgct ccttccagga cctggacctc tgccctctgg atggcggcat ccagctacga 240 atctccgacc accactacag caagggcttc aggcaggccg cgtcagttgt tgtggccatg 300 gacaagctga ggaagatgct ggttccctgc ccacagacct tccaggagaa tgacctgagc 360 accttctttc ccttcatctt tgaagaagaa cctatcttct tcgacacatg ggataacgag 420 gcttatgtgc acgatgcacc tgtacgatca ctgaactgca cgctccggga ctcacagcaa 480 aaaagcttgg tgatgtctgg tccatatgaa ctgaaagctc tccacctcca gggacaggat 540 atggagcaac aagtggtgtt ctccatgtcc tttgtacaag gagaagaaag taatgacaaa 600 atacctgtgg ccttgggcct caaggaaaag aatctgtacc tgtcctgcgt gttgaaagat 660 gataagccca ctctacagct ggagagtgta gatcccaaaa attacccaaa gaagaagatg 720 gaaaagcgat ttgtcttcaa caagatagaa atcaataaca agctggaatt tgagtctgcc 780 cagttcccca actggtacat cagcacctct caagcagaaa acatgcccgt cttcctggga 840 gggaccaaag gcggccagga tataactgac ttcaccatgc aatttgtgtc ttcctaaaga 900 gagctgtacc cagagagtcc tgtgctgaat gtggactcaa tccctagggc tggcagaaag 960 ggaacagaaa ggtttttgag tacggctata gcctggactt tcctgttgtc tacaccaatg 1020 cccaactgcc tgccttaggg tagtgctaag aggatctcct gtccatcagc caggacagtc 1080 agctctctcc tttcagggcc aatccccagc ccttttgttg agccaggcct ctctcacctc 1140 tcctactcac ttaaagcccg cctgacagaa accacggcca catttggttc taagaaaccc 1200 tctgtcattc gctcccacat tctgatgagc aaccgcttcc ctatttattt atttatttgt 1260 ttgtttgttt tattcattgg tctaatttat tcaaaggggg caagaagtag cagtgtctgt 1320 aaaagagcct agtttttaat agctatggaa tcaattcaat ttggactggt gtgctctctt 1380 taaatcaagt cctttaatta agactgaaaa tatataagct cagattattt aaatgggaat 1440 atttataaat gagcaaatat catactgttc aatggttctg aaataaactt cactgaag 1498 <210> 224 <211> 1197 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1197) <223> IL-6 mRNA <400> 224 gtctcaatat tagagtctca acccccaata aatataggac tggagatgtc tgaggctcat 60 tctgccctcg agcccaccgg gaacgaaaga gaagctctat ctcccctcca ggagcccagc 120 tatgaactcc ttctccacaa gcgccttcgg tccagttgcc ttctccctgg ggctgctcct 180 ggtgttgcct gctgccttcc ctgccccagt acccccagga gaagattcca aagatgtagc 240 cgccccacac agacagccac tcacctcttc agaacgaatt gacaaacaaa ttcggtacat 300 cctcgacggc atctcagccc tgagaaagga gacatgtaac aagagtaaca tgtgtgaaag 360 cagcaaagag gcactggcag aaaacaacct gaaccttcca aagatggctg aaaaagatgg 420 atgcttccaa tctggattca atgaggagac ttgcctggtg aaaatcatca ctggtctttt 480 ggagtttgag gtatacctag agtacctcca gaacagattt gagagtagtg aggaacaagc 540 cagagctgtg cagatgagta caaaagtcct gatccagttc ctgcagaaaa aggcaaagaa 600 tctagatgca ataaccaccc ctgacccaac cacaaatgcc agcctgctga cgaagctgca 660 ggcacagaac cagtggctgc aggacatgac aactcatctc attctgcgca gctttaagga 720 gttcctgcag tccagcctga gggctcttcg gcaaatgtag catgggcacc tcagattgtt 780 gttgttaatg ggcattcctt cttctggtca gaaacctgtc cactgggcac agaacttatg 840 ttgttctcta tggagaacta aaagtatgag cgttaggaca ctattttaat tatttttaat 900 ttattaatat ttaaatatgt gaagctgagt taatttatgt aagtcatatt tatattttta 960 agaagtacca cttgaaacat tttatgtatt agttttgaaa taataatgga aagtggctat 1020 gcagtttgaa tatcctttgt ttcagagcca gatcatttct tggaaagtgt aggcttacct 1080 caaataaatg gctaacttat acatattttt aaagaaatat ttatattgta tttatataat 1140 gtataaatgg tttttatacc aataaatggc attttaaaaa attcagcaaa aaaaaaa 1197 <210> 225 <211> 9027 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(9027) <223> IL-6ST mRNA <400> 225 ggatctgaca gtgttccgga gccggggcga gcagccaaaa ggcccgcgga gtcgcgctgg 60 gccgccccgg cgcagctgaa ccgggggccg cgcctgccag gccgacgggt ctggcccagc 120 ctggcgccaa ggggttcgtg cgctgtggag acgcggaggg tcgaggcggc gcggcctgag 180 tgaaacccaa tggaaaaagc atgacattta gaagtagaag acttagcttc aaatccctac 240 tccttcactt actaattttg tgatttggaa atatccgcgc aagatgttga cgttgcagac 300 ttggctagtg caagccttgt ttattttcct caccactgaa tctacaggtg aacttctaga 360 tccatgtggt tatatcagtc ctgaatctcc agttgtacaa cttcattcta atttcactgc 420 agtttgtgtg ctaaaggaaa aatgtatgga ttattttcat gtaaatgcta attacattgt 480 ctggaaaaca aaccatttta ctattcctaa ggagcaatat actatcataa acagaacagc 540 atccagtgtc acctttacag atatagcttc attaaatatt cagctcactt gcaacattct 600 tacattcgga cagcttgaac agaatgttta tggaatcaca ataatttcag gcttgcctcc 660 agaaaaacct aaaaatttga gttgcattgt gaacgagggg aagaaaatga ggtgtgagtg 720 ggatggtgga agggaaacac acttggagac aaacttcact ttaaaatctg aatgggcaac 780 acacaagttt gctgattgca aagcaaaacg tgacaccccc acctcatgca ctgttgatta 840 ttctactgtg tattttgtca acattgaagt ctgggtagaa gcagagaatg cccttgggaa 900 ggttacatca gatcatatca attttgatcc tgtatataaa gtgaagccca atccgccaca 960 taatttatca gtgatcaact cagaggaact gtctagtatc ttaaaattga catggaccaa 1020 cccaagtatt aagagtgtta taatactaaa atataacatt caatatagga ccaaagatgc 1080 ctcaacttgg agccagattc ctcctgaaga cacagcatcc acccgatctt cattcactgt 1140 ccaagacctt aaacctttta cagaatatgt gtttaggatt cgctgtatga aggaagatgg 1200 taagggatac tggagtgact ggagtgaaga agcaagtggg atcacctatg aagatagacc 1260 atctaaagca ccaagtttct ggtataaaat agatccatcc catactcaag gctacagaac 1320 tgtacaactc gtgtggaaga cattgcctcc ttttgaagcc aatggaaaaa tcttggatta 1380 tgaagtgact ctcacaagat ggaaatcaca tttacaaaat tacacagtta atgccacaaa 1440 actgacagta aatctcacaa atgatcgcta tctagcaacc ctaacagtaa gaaatcttgt 1500 tggcaaatca gatgcagctg ttttaactat ccctgcctgt gactttcaag ctactcaccc 1560 tgtaatggat cttaaagcat tccccaaaga taacatgctt tgggtggaat ggactactcc 1620 aagggaatct gtaaagaaat atatacttga gtggtgtgtg ttatcagata aagcaccctg 1680 tatcacagac tggcaacaag aagatggtac cgtgcatcgc acctatttaa gagggaactt 1740 agcagagagc aaatgctatt tgataacagt tactccagta tatgctgatg gaccaggaag 1800 ccctgaatcc ataaaggcat accttaaaca agctccacct tccaaaggac ctactgttcg 1860 gacaaaaaaa gtagggaaaa acgaagctgt cttagagtgg gaccaacttc ctgttgatgt 1920 tcagaatgga tttatcagaa attatactat attttataga accatcattg gaaatgaaac 1980 tgctgtgaat gtggattctt cccacacaga atatacattg tcctctttga ctagtgacac 2040 attgtacatg gtacgaatgg cagcatacac agatgaaggt gggaaggatg gtccagaatt 2100 cacttttact accccaaagt ttgctcaagg agaaattgaa gccatagtcg tgcctgtttg 2160 cttagcattc ctattgacaa ctcttctggg agtgctgttc tgctttaata agcgagacct 2220 aattaaaaaa cacatctggc ctaatgttcc agatccttca aagagtcata ttgcccagtg 2280 gtcacctcac actcctccaa ggcacaattt taattcaaaa gatcaaatgt attcagatgg 2340 caatttcact gatgtaagtg ttgtggaaat agaagcaaat gacaaaaagc cttttccaga 2400 agatctgaaa tcattggacc tgttcaaaaa ggaaaaaatt aatactgaag gacacagcag 2460 tggtattggg gggtcttcat gcatgtcatc ttctaggcca agcatttcta gcagtgatga 2520 aaatgaatct tcacaaaaca cttcgagcac tgtccagtat tctaccgtgg tacacagtgg 2580 ctacagacac caagttccgt cagtccaagt cttctcaaga tccgagtcta cccagccctt 2640 gttagattca gaggagcggc cagaagatct acaattagta gatcatgtag atggcggtga 2700 tggtattttg cccaggcaac agtacttcaa acagaactgc agtcagcatg aatccagtcc 2760 agatatttca cattttgaaa ggtcaaagca agtttcatca gtcaatgagg aagattttgt 2820 tagacttaaa cagcagattt cagatcatat ttcacaatcc tgtggatctg ggcaaatgaa 2880 aatgtttcag gaagtttctg cagcagatgc ttttggtcca ggtactgagg gacaagtaga 2940 aagatttgaa acagttggca tggaggctgc gactgatgaa ggcatgccta aaagttactt 3000 accacagact gtacggcaag gcggctacat gcctcagtga aggactagta gttcctgcta 3060 caacttcagc agtacctata aagtaaagct aaaatgattt tatctgtgaa ttcagatttt 3120 aaaaagtctt cactctctga agatgatcat ttgcccttaa ggacaaaaat gaactgaagt 3180 ttcacatgag ctatttccat tccagaatat ctgggattct actttaagca ctacataaac 3240 tgactttatc ctcagactag ctgaatgatt ttgtgctgtt tcaggatgtt tgcactgaag 3300 aaaaacagaa agcttatctg aaatttataa aactttttgt tttgctacat agaaaacaga 3360 aggtatttga ataataagca gtgatatgct tagtgagcac agctatactg attttgatta 3420 gaatagtcat cagagtggct tagggacagt taatataaaa gaggagcaag gtgtagacca 3480 tcatctactt ctgctaaaat aacttaaaaa gaggtccata ggccataact acatgagccc 3540 agcttttgta atctgacaaa aaaatgagga gcagcttcgt gtatatcagt gtacacggta 3600 ttccttaggt cccttccatt ggtagtgatg ctgcgagtta ttactggaga aaaggaattc 3660 tagagcttta acttggcaga ttaaaagtac tcatttttta ttcatcaata attagtaatc 3720 tcactagttt tcaaaaattt gcatattatt gacaacctct ttgaagatgc atttcacaaa 3780 ctcaacagag tgccatgata agagctaggg atcccccaaa ctatctcaag catctaaaaa 3840 attgccattt ttaaaggctt aaattgtagt agtaaagggg aaaacaggaa gtagtagtaa 3900 aggggaaaaa aaaccaataa agcatctaaa aaattggcat gttaaaaggc ttaaattgct 3960 aatgtgtgta tatatatata tatatataca cacacatatc attgactttt cttaagactt 4020 cagagtactg ggtagatgaa cactttatac agtatatatc ttcagcttaa atttgttttg 4080 agtatttttt ttatttttaa ataagtaggc aaagatttaa atttttttat ttttagtaaa 4140 tgtttgaggc acactaagac aacttgggca atatttgcca aaacaaaaca gaaccccaaa 4200 aaatgtacat cttgttctta gcaaatatca ttattgtaga gacacttaat aaagagatgg 4260 tattttaatg tctgcagttc tgaggtaggg tggaacttag ttctacattg tgatttagga 4320 atttttaaaa ccttttttct tcaagggaga agtgacccag gcctcgagtt tagtgctaaa 4380 gccgctagtg tacttatgct gtcccctaac caccacgtgc gatatggaag cagatgctaa 4440 atataggggt tttcttagaa agtaagagga aattagcaag cgttattagt gattgactac 4500 tgctatcaag tgaattcaaa ggaaacaggt ttttatgcca tatttaagtt acagaaacca 4560 ggcatgctta gaatagtttc tagaggttat tggagaatag aaagctaaga aaacttggta 4620 tacatttaca atggaaatat aattacactt tttactctca gaatattgtt cacattagac 4680 ttcctgttta tcttttatat tcttgcattt atataatgcc tcatcctttc aaagttcttt 4740 cacatattat atgatcttct ttatgaaaaa aatagatgtt tcattctgat atattcagtt 4800 tcccacttta ggcaaaagta gattaataga atgacgaatt caaagtagat gaggaaaatc 4860 aggcacagag aagtaaaggt agggatagac ccaaatttac acaacaagat aatgacatct 4920 ccagctttta agttgatcat caaaggctgg gctggatttg tcttgctgta tgtgtcagga 4980 aatttatacc tattacattt tccattttct caaaatttaa gtcacatgac taatatttag 5040 ctgcaacttt cctcataaca aatagtgtca tgaagaatgt tgtagtgtga agtttgtaca 5100 tttcagggtc agatatacaa tatgaactct taatctacag gaatgagaat ggaggatcat 5160 tgaaggccat gatataaaca aatttgcatg ttgaagcctg tataaaacat ggtacagtga 5220 gtgaatatac ccccatcccc aagaacactt tatacatatt aaatggatat atgattactg 5280 tgcaaaaatt cattctggaa atgaacatat atttgagcac taatatgtaa tgtacacctg 5340 ccctaaggag aaaataaatt ataaaacttt ttacattcaa aattactttc ccaagcatgt 5400 cttagaataa tctatgtgtt gatgcatgta aattgtactt taggtaggca aagaaatctg 5460 gttatttatg taaaaactag tctaataaag ttagttagtg gctttatcac tttaaatctt 5520 tagtgtccaa aagtggtgtt taaagtaata gcacatcaga aaaccttgtc tggacaaaac 5580 tagttcactc actgcttctg cacctgcagt tgctcccttt agggttataa aataatgacc 5640 caaatgttac atgtgttgat attataactt gtcagttact gatgtctgtg gtatcctacc 5700 ctcatctctg aaagggataa tactgaataa ttattagaaa actataaaac ttcacacttt 5760 gtaccattaa aacctaaaat tttaatcttg tcctttttta ctatggatca gtcggcactc 5820 gggaacagca gcaaggaaaa aaagcaaatt tcattcacat gttctgtgtt catacctctt 5880 ctctacctaa ttgttcattt aaatttcagc cttattcctt gataagggat tttaccacat 5940 gaagtcatcc agtgacccta gctcttattg tgaagttagt ggagtatact tagaaatgtt 6000 acaactttaa aatgttacaa aacattcatt aaagctcata tttaaagtag agcatctagt 6060 ttgagaaata gaaatcaatt attaaagatg tcttttttct acccatttaa ctagttaaaa 6120 ccatgacatg taaatgtaga agtagaataa tcatagaatt ccctaaaata tttctgttta 6180 ctaacatata ttgaccaagt acatcaagca ggagagatct tccttcattc tgttatagtc 6240 cacatcattc taattttgct cagttgttat taagagcata ttcctaaacc atacactttt 6300 gtttcaataa agttttattt tgttgagatg aataaaataa caaagttata agctgcataa 6360 gacaaaagtt caattgttca aaaaaaattt actgggatag ctttctatta caggtattgt 6420 tagattatat tgtgctgata agattacttt ctaaaaaatt tgtacttttc tgtaaattaa 6480 aagaatatgg agtcataaaa tggcaagtgt tttaggatta gcctaaaatt ggacattgtc 6540 attgatttca aagaaggtat gaactagcag tcttacagcc taattcttct ttggactggt 6600 ccttggcagc agttcctttt cagactcgat aaacagaatt cagatgatgt aagtcaaaac 6660 aaaactttac aaagccaagc gtattatctt ttgcattaac ctattttttt ccatcataca 6720 tgctactagt atgtgcatta gcatgatatt ctcatataca ttgcattaaa aattaaaagg 6780 tggcagctca gggtgagctc ttctgttgct catttgttcc taaattttta agggcttttt 6840 ctcagtcaat agtttgtaca aactggttag tttaacttca ttacccattt cattaaagtt 6900 gatgggtcgt gtgatgagat gcatttaagg ccgatagtga tagatgtttt ttttatttct 6960 tgaacacagg ctttgtctga atgatgttct tttatctctt gaacacaagc tttgaatgat 7020 aactacaggt tttaagtgct gttacattaa taccataatg tgatgtgtta gaaacaaagg 7080 gatatttcaa aggtagatat ttgaaaattc tctagtctca atatgtatgt gtattgaata 7140 tactctaaaa ataaatgtgc aatttgctag taggacaatg cagtgactga ctagcattag 7200 gtatgtttct tttatatcct agctatgtcc cactttcttc taagtgcaat cctttcatgt 7260 tcacttgctg ttttacccca tctactctaa cttcatttgg aaggcttgtc tagagtatag 7320 catgtatttt tacctttgca gtgaattgca tgtgctaatt gtaaccacag ctatttttat 7380 gttgacataa ctccaaatgt tatattaaat gttctattat atattagctc taatccctta 7440 agtaaatttt aagaaataaa tacttgttca aatttttttt ctgtatgtgg ttactatcat 7500 ctgactatgc atatttgtaa cagcatttat cattagtggt gttagctaaa taagcatctt 7560 agtgtaaatg agatgcttcg tgtgggtttt gtgacatttt aaatgacata atggaatgtg 7620 atttaaaaga aaaccagtac actatcttgg tcttaataac atagaatgga gatggcaaat 7680 ttatccacta gttttccaga tttactattt aatagctgag gtctgaaatc gtagcatcct 7740 ccctcctagt ggacattaaa aaaaaaaaaa aaaaaaaaaa cctacttggt tgtcaagagc 7800 ccaagtatgg aggtgctgcg ccatcttgtg gcctgtctgt gcccaccctg cactctgctg 7860 gagtctccat ccttgttgca gtgagacttg aagttcaaga ttgatacatg gcatcctcct 7920 gctacttctt gaggttacta agtagtatat gaaactaatc agtcagcaag tccacctgga 7980 aggaaaagaa aatctcaact attaatgtgc cttcacattg tgattttgtc taaaaaaatg 8040 tagtgagtca aaaaacccac aagccagcca acagtaactc cttcacatat ataccagagt 8100 ttatagaaat aacatgtcag ctttgggcta tgtgctcctt tgtttaaaat cttctatttg 8160 gttatggctt gtataggctc aagcctgatt tctttaaggt gtggtggctc atcttatcct 8220 aatgtgtatg atagatacag tccatcctgc tttggaaaag attatgtaac tccttgagag 8280 catactcttt ctctagccca aaggcagtga gagagttttc ttgttcagga ttgcttaact 8340 ttccatttaa gctttttctt tttaaattaa tacaaacttc tacactttca aaatacgaaa 8400 tatattacaa ctgcgtatag gctcttccat acttaagtcc agtgcttggg caagttaatg 8460 gagtgaaaga ctacaagcaa agaggaactg aggtagaaaa agaagaatgt gtgaaagcag 8520 caggaagctc agccaactcg aaagcagggt gaacagcttg agtcctgttg ctgctgatcg 8580 gggttggctc ttggacaact tagtaagatc atggaaaggc tgcttgggtt ctccatagaa 8640 aagttctgtc tccatcaagg gaggaaaatg tacctttcaa ctcaaaattc aatatttgtt 8700 tttaaatata gctattttcc ccaaccgcta aagattttca acagatacga agccagagct 8760 tagttttaga aacctgtgga cattcaaacc tgattcttta ttccctgtga ctatggttat 8820 gtcattttac atgtcaaaaa agtgtatcta gaattgtcat ttcttatttt tgagcttttt 8880 ttagtgagaa ttatcccctc acttaaatgg ctttttattt aaacatctgt gcattctgta 8940 tgaaattgta gtctttctgg gataacatgg tgagctatat ggtggtaatc cacacacaca 9000 aaaataaaag ccaaaaaaaa accaaaa 9027 <210> 226 <211> 4643 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4643) <223> IL-7R mRNA <400> 226 gtggttagat aagtataaag ccctagatct aagcttctct gtcttcctcc ctccctccct 60 tcctcttact ctcattcatt tcatacacac tggctcacac atctactctc tctctctatc 120 tctctcagaa tgacaattct aggtacaact tttggcatgg ttttttcttt acttcaagtc 180 gtttctggag aaagtggcta tgctcaaaat ggagacttgg aagatgcaga actggatgac 240 tactcattct catgctatag ccagttggaa gtgaatggat cgcagcactc actgacctgt 300 gcttttgagg acccagatgt caacatcacc aatctggaat ttgaaatatg tggggccctc 360 gtggaggtaa agtgcctgaa tttcaggaaa ctacaagaga tatatttcat cgagacaaag 420 aaattcttac tgattggaaa gagcaatata tgtgtgaagg ttggagaaaa gagtctaacc 480 tgcaaaaaaa tagacctaac cactatagtt aaacctgagg ctccttttga cctgagtgtc 540 gtctatcggg aaggagccaa tgactttgtg gtgacattta atacatcaca cttgcaaaag 600 aagtatgtaa aagttttaat gcacgatgta gcttaccgcc aggaaaagga tgaaaacaaa 660 tggacgcatg tgaatttatc cagcacaaag ctgacactcc tgcagagaaa gctccaaccg 720 gcagcaatgt atgagattaa agttcgatcc atccctgatc actattttaa aggcttctgg 780 agtgaatgga gtccaagtta ttacttcaga actccagaga tcaataatag ctcaggggag 840 atggatccta tcttactaac catcagcatt ttgagttttt tctctgtcgc tctgttggtc 900 atcttggcct gtgtgttatg gaaaaaaagg attaagccta tcgtatggcc cagtctcccc 960 gatcataaga agactctgga acatctttgt aagaaaccaa gaaaaaattt aaatgtgagt 1020 ttcaatcctg aaagtttcct ggactgccag attcataggg tggatgacat tcaagctaga 1080 gatgaagtgg aaggttttct gcaagatacg tttcctcagc aactagaaga atctgagaag 1140 cagaggcttg gaggggatgt gcagagcccc aactgcccat ctgaggatgt agtcatcact 1200 ccagaaagct ttggaagaga ttcatccctc acatgcctgg ctgggaatgt cagtgcatgt 1260 gacgccccta ttctctcctc ttccaggtcc ctagactgca gggagagtgg caagaatggg 1320 cctcatgtgt accaggacct cctgcttagc cttgggacta caaacagcac gctgccccct 1380 ccattttctc tccaatctgg aatcctgaca ttgaacccag ttgctcaggg tcagcccatt 1440 cttacttccc tgggatcaaa tcaagaagaa gcatatgtca ccatgtccag cttctaccaa 1500 aaccagtgaa gtgtaagaaa cccagactga acttaccgtg agcgacaaag atgatttaaa 1560 agggaagtct agagttccta gtctccctca cagcacagag aagacaaaat tagcaaaacc 1620 ccactacaca gtctgcaaga ttctgaaaca ttgctttgac cactcttcct gagttcagtg 1680 gcactcaaca tgagtcaaga gcatcctgct tctaccatgt ggatttggtc acaaggttta 1740 aggtgaccca atgattcagc tatttaaaaa aaaaagagga aagaatgaaa gagtaaagga 1800 aatgattgag gagtgaggaa ggcaggaaga gagcatgaga ggaaagaaag aaaggaaaat 1860 aaaaaatgat agttgccatt attaggattt aatatatatc cagtgctttg caagtgctct 1920 gcgcaccttg tctcactcca tcctgacaat aatcctggga ggtgtgtgca attactacga 1980 ctactctctt ttttatagat cattaaattc agaactaagg agttaagtaa cttgtccaag 2040 ttgttcacac agtgaaggga ggggccaaga tatgatggct gggagtctaa ttgcagttcc 2100 ctgagccatg tgcctttctc ttcactgagg actgccccat tcttgagtgc caaacgtcac 2160 tagtaacagg gtgtgcctag ataatttatg atccaaactg agtcagtttg gaaagtgaaa 2220 gggaaactta catataatcc ctccgggaca atgagcaaaa actaggactg tccccagaca 2280 aatgtgaaca tacatatcat cacttaaatt aaaatggcta tgagaaagaa agagggggag 2340 aaacagtctt gcgggtgtga agtcccatga ccagccatgt caaaagaagg taaagaagtc 2400 aagaaaaagc catgaagccc atttggtttc atttttctga aaataggctc aagagggaat 2460 aaattagaaa ctcacaattt ctcttgtttg ttaccaagac agtgattctc ttgctgctac 2520 cacccaactg catccgtcca tgatctcaga ggaaactgtc gctgaccctg gacatgggta 2580 cgtttgacga gtgagaggag gcatgacccc tcccatgtgt atagacacta ccccaaccta 2640 aattcatccc taaattgtcc caagttctcc agcaatagag gctgccacaa acttcaggga 2700 gaaagagtta caagtacatg caatgagtga actgactgtg gctacaatct tgaagatata 2760 cggaagagac gtattattaa tgcttgacat atatcatctt gcctttcttg gtctagactg 2820 acttctaatg actaactcaa agtcaaggca actgagtaat gtcagctcag caaagtgcag 2880 caaacccatc tcccacaggc ctccaaaccc tggctgttca cagaaccaca aagggcagat 2940 gctgcacaga aaactagaga aggggtcata ggttcatggt tttgtttgag atttgttgct 3000 actgtttttc tgttttgaat tttcttcttt gttctgtttt tactttattt agggggacta 3060 ggtgtttctg atattttagt tttcttgttt gttttgtttt gtgttgtctg tgaatggggt 3120 tttaactgtg gatgaatgga ccttatctgt tggcttaaag gactggtaag atcagaccat 3180 cttattcttc aggtgaatgt tttactttcc aaagtgctct cctctgcacc agcagtaata 3240 aatacaatgc cataatccct taggtttgcc tagtgctttt gcaattttca aagcacttcc 3300 ataagcattc cttccacctc cttgataggc atttatggaa agcctgctac atgtcaatca 3360 tactgttagg cacaggggac ctaaagacac ataaaaggat ggcattctgc ctcataaatt 3420 gcaaaaccta atgaaagtga ctgcttggta aacaaattat tattatatta taaaatgcta 3480 taaaagagcc atattgaaag tgccctgttg gagacagggc aaatgccaca aaaatgatgt 3540 aaatttacat ggaggaaaag tagaatctgc ctggtttgta ggcagcagaa gacatttttc 3600 atcagtgggc aggtgttctt taccttttgt agaaatggga gtcaagtctc aaataggagg 3660 ctccacaaaa tctcatgcca ggtctctgat accttattca cagaagttct ttgaagtatt 3720 tattgttatt ttctttgact tatgggaaaa ctgggacaca ggaagacagg taaattaccc 3780 aacctcacac gttaagtcag aactgggagc cataattttg tatccctggt ataaatagac 3840 aatctcttga agaaatgaag agatgaccat agaaaaacat cgagatatct ccagctctaa 3900 aatcctttgt ttcaatgttg tttggcatat gttatctttg gaatttagtg tctgagcctc 3960 tgtctgttac tgtagtattt aaaatgcatg tattataatc atataatcat aactgctgtt 4020 aattcttgat tatataccta gggacaatgt gtaatgtaag attactaatt ggttctgccc 4080 aatctccttt cagattttat taggaaaaaa aaataaacct cctgatcgga gacaatgtat 4140 taatcagaag tgtaaactgc cagttctata tagcatgaaa tgaaaagaca gctaatttgg 4200 tccaacaaac atgactgggt ctagggcacc caggctgatt cagctgattt cctaccagcc 4260 tttgcctctt ccttcaatgt ggtttccatg ggaatttgct tcagaaaagc caagtatggg 4320 ctgttcagag gtgcacacct gcattttctt agctcttcta gaggggctaa gagacttggt 4380 acgggccagg aagaatatgt ggcagagctc ctggaaatga tgcagattag gtggcatttt 4440 tgtcagctct gtggtttatt gttgggacta ttctttaaaa tatccattgt tcactacagt 4500 gaagatctct gatttaaccg tgtactatcc acatgcatta caaacatttc gcagagctgc 4560 ttagtatata agcgtacaat gtatgtaata accatctcat atttaattaa atggtataga 4620 agaacaaaaa aaaaaaaaaa aaa 4643 <210> 227 <211> 1642 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1642) <223> IL-8 mRNA <400> 227 acaaactttc agagacagca gagcacacaa gcttctagga caagagccag gaagaaacca 60 ccggaaggaa ccatctcact gtgtgtaaac atgacttcca agctggccgt ggctctcttg 120 gcagccttcc tgatttctgc agctctgtgt gaaggtgcag ttttgccaag gagtgctaaa 180 gaacttagat gtcagtgcat aaagacatac tccaaacctt tccaccccaa atttatcaaa 240 gaactgagag tgattgagag tggaccacac tgcgccaaca cagaaattat tgtaaagctt 300 tctgatggaa gagagctctg tctggacccc aaggaaaact gggtgcagag ggttgtggag 360 aagtttttga agagggctga gaattcataa aaaaattcat tctctgtggt atccaagaat 420 cagtgaagat gccagtgaaa cttcaagcaa atctacttca acacttcatg tattgtgtgg 480 gtctgttgta gggttgccag atgcaataca agattcctgg ttaaatttga atttcagtaa 540 acaatgaata gtttttcatt gtaccatgaa atatccagaa catacttata tgtaaagtat 600 tatttatttg aatctacaaa aaacaacaaa taatttttaa atataaggat tttcctagat 660 attgcacggg agaatataca aatagcaaaa ttgaggccaa gggccaagag aatatccgaa 720 ctttaatttc aggaattgaa tgggtttgct agaatgtgat atttgaagca tcacataaaa 780 atgatgggac aataaatttt gccataaagt caaatttagc tggaaatcct ggattttttt 840 ctgttaaatc tggcaaccct agtctgctag ccaggatcca caagtccttg ttccactgtg 900 ccttggtttc tcctttattt ctaagtggaa aaagtattag ccaccatctt acctcacagt 960 gatgttgtga ggacatgtgg aagcacttta agttttttca tcataacata aattattttc 1020 aagtgtaact tattaaccta tttattattt atgtatttat ttaagcatca aatatttgtg 1080 caagaatttg gaaaaataga agatgaatca ttgattgaat agttataaag atgttatagt 1140 aaatttattt tattttagat attaaatgat gttttattag ataaatttca atcagggttt 1200 ttagattaaa caaacaaaca attgggtacc cagttaaatt ttcatttcag ataaacaaca 1260 aataattttt tagtataagt acattattgt ttatctgaaa ttttaattga actaacaatc 1320 ctagtttgat actcccagtc ttgtcattgc cagctgtgtt ggtagtgctg tgttgaatta 1380 cggaataatg agttagaact attaaaacag ccaaaactcc acagtcaata ttagtaattt 1440 cttgctggtt gaaacttgtt tattatgtac aaatagattc ttataatatt atttaaatga 1500 ctgcattttt aaatacaagg ctttatattt ttaactttaa gatgttttta tgtgctctcc 1560 aaattttttt tactgtttct gattgtatgg aaatataaaa gtaaatatga aacatttaaa 1620 atataatttg ttgtcaaagt aa 1642 <210> 228 <211> 4811 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4811) <223> ITGA1 mRNA <400> 228 ggtcctgccc tgcgaaccag cgcggccccc tggcgctgag gctgctccgg ccatggcccc 60 tcggccccgc gcccgcccag gggtcgctgt cgcctgctgc tggctcctca ctgttgttct 120 acgctgctgc gtatcattca atgttgatgt gaaaaattca atgactttca gcggcccggt 180 ggaagacatg tttggatata ctgttcaaca atatgaaaat gaagaaggaa aatgggtgct 240 tattggttct ccgttagttg gccaacccaa aaacagaact ggagatgtct ataagtgtcc 300 agttgggaga ggtgaatcat taccttgtgt aaagttggat ctaccagtta atacatcaat 360 tcccaatgtc acagaagtaa aggagaacat gacatttgga tcaactttag tcaccaaccc 420 aaatggagga tttctggctt gtgggccctt atatgcctat agatgtggac atttgcatta 480 cacaactgga atctgttctg acgtcagccc cacatttcaa gtcgtgaatt ccattgcccc 540 tgtacaagaa tgcagcactc aactggacat agtcatagtg ctggatggtt ccaacagtat 600 ttacccatgg gacagtgtta cagctttttt aaatgacctt cttgaaagaa tggatattgg 660 tcctaaacag acacaggttg gaattgtaca gtatggagaa aacgtgaccc atgagttcaa 720 cctcaataag tattcttcca ccgaagaggt acttgttgca gcaaagaaaa tagtccagag 780 aggtggccgc cagactatga cagctcttgg aatagacaca gcaagaaagg aggcattcac 840 ggaagcccgg ggtgcccgaa gaggagttaa aaaagtcatg gttattgtga cagatggaga 900 gtctcatgac aatcatcgac tgaagaaggt catccaagac tgtgaagatg aaaacattca 960 acggttttcc atagctattc ttggcagcta taaccgagga aatttaagca ctgaaaaatt 1020 tgtggaggaa ataaaatcaa ttgcaagtga acccactgaa aagcatttct tcaatgtctc 1080 tgatgaattg gctctagtca ccattgttaa aactctggga gaaagaatat ttgccctgga 1140 agccacagct gaccagtcag cagcttcatt tgaaatggaa atgtctcaga ctggcttcag 1200 tgctcattat tcacaggact gggtcatgct tggagcagta ggagcctatg attggaatgg 1260 aacagttgtc atgcagaagg ctagtcaaat cataatccct cgaaacacaa cctttaatgt 1320 tgagtctacc aaaaagaatg aaccgcttgc ttcttattta ggttacactg taaactctgc 1380 tactgcttct tctggagatg tgctctatat tgctggacag cctcggtaca atcatacagg 1440 ccaggtcatt atctacagga tggaagatgg aaacatcaaa attctccaga cgctcagtgg 1500 agaacagatt ggttcctact ttggcagtat tttaacaaca actgacattg acaaggattc 1560 taatactgac attcttctag tcggagcccc tatgtacatg ggaacagaga aggaggagca 1620 aggaaaagtg tatgtgtatg ctctcaatca gacaaggttt gaatatcaaa tgagcctgga 1680 acctattaag cagacgtgct gttcatctcg gcagcacaat tcatgcacaa cagaaaacaa 1740 aaatgagcca tgcggggctc gttttggaac tgcaattgct gctgtaaaag acctcaatct 1800 tgatggattt aatgacatcg tgataggagc tccgctggaa gatgatcacg ggggagctgt 1860 gtacatttat catggaagtg gcaagactat aaggaaagag tatgcacaac gtattccatc 1920 aggtggggat ggtaagacac tgaaattttt tggccagtct atccacggag aaatggattt 1980 aaatggtgac ggtctgacag atgtgactat tgggggcctt ggtggtgctg ccctcttctg 2040 gtcccgagat gtggccgtag ttaaagtgac catgaatttt gagccaaata aagtgaatat 2100 tcaaaagaaa aactgccata tggagggaaa ggaaacagta tgcataaatg ctacagtgtg 2160 ttttgatgtg aaattaaagt ctaaagaaga cacgatttat gaagctgatt tgcagtaccg 2220 tgtcacccta gattcactaa gacaaatatc acgaagtttt ttctctggaa ctcaagagag 2280 aaaggttcaa aggaacatca cagttcgaaa atcagaatgc actaagcact ccttctacat 2340 gttggacaag catgactttc aggactctgt gagaataacg ttggacttta atcttaccga 2400 tccagaaaat gggcctgttc ttgatgattc tctaccaaac tcagtacatg aatatattcc 2460 ctttgccaaa gattgtggaa ataaggaaaa atgtatctca gacctcagcc tgcatgtcgc 2520 caccactgaa aaggacctgc tgattgtccg atcccagaat gataagttca acgttagcct 2580 cacagtcaaa aatacaaagg acagtgccta taacaccagg acaatagtgc attattctcc 2640 aaatctagtt ttttcaggaa ttgaggctat ccaaaaagac agttgtgaat ctaatcataa 2700 tatcacatgt aaagttggat atcccttcct gagaagagga gagatggtaa ctttcaaaat 2760 attgtttcag tttaacacat cctatctcat ggaaaatgtg accatttatt taagtgcaac 2820 aagtgacagc gaagaacctc ctgaaaccct ttctgataat gtagtaaaca tttctatccc 2880 ggtaaaatat gaagttggac tacagtttta cagctctgca agtgaatacc acatttcaat 2940 tgctgccaat gagacagtcc ctgaagttat taattctact gaggacattg gaaatgaaat 3000 taatatcttc tacttgatta gaaaaagtgg atcttttcca atgccagagc ttaagctgtc 3060 aatttcattc cccaatatga catcaaatgg ttaccctgtg ctgtacccaa ctggattgtc 3120 atcttctgag aatgcaaact gcagacccca tatctttgag gatcctttca gtatcaactc 3180 tggaaagaaa atgactacat caactgacca tctcaaacga ggcacaattc tggactgcaa 3240 tacatgtaaa tttgctacca tcacatgtaa tctcacttct tctgacatca gccaagtcaa 3300 tgtttcgctt atcttgtgga aaccaacttt tataaaatca tatttttcca gcttaaatct 3360 tactataagg ggagaacttc ggagtgaaaa tgcatctctg gttttaagta gcagcaatca 3420 aaaaagagag cttgctattc aaatatccaa agatgggcta ccgggcagag tgccattatg 3480 ggtcatcctg ctgagtgctt ttgccggatt gttgctgtta atgctgctca ttttagcact 3540 gtggaagatt ggattcttca aaagaccact gaaaaagaaa atggagaaat gaaatatttt 3600 atgaaagaaa ataataacaa ttattcaata atctatcctc aggtttgcct caaatatgtg 3660 acaagaaatg tataattcat gacatagtca tgtaactatg taatccatca gggattcatt 3720 acttggaaaa tgacaggtca tgcattatcc aaaaacaata ccaaaaagac atattttata 3780 aaatgacaaa aaatatttta cataattact catttttgtt gagtaagcaa aattacaaag 3840 tgtttttaaa aaaacctgta caaatatgtt tatgtattaa atcaccatcc aaaatattta 3900 aggaatatat aaaaagattt ttatgatcat agaaacatct attttcaaaa caatataaat 3960 taagcttttc cccttgattc ctgttggata tccatgttca gcatgacagt cagcactcgt 4020 aaatgccaag aaaagaatta cctgaaaaag atcatttctc cctattcaaa tgagaatatt 4080 ttcccttggt agaatccata tacaatatgg attgaaaatt aagtcaccaa gaatacattt 4140 agcatctttg tgttgggttc tatacctaaa aattttccct ccctgcccaa ggtgattgga 4200 aagtactgca attgagctaa aattttatct aggatggaaa atcaggatag actcgtttaa 4260 aaacaagtat attaaatggg ttaaattaag cttttacaga acatgcttaa ttttgatatt 4320 gagctctaaa tgcaaaactc ttttatactg aaaaaacact taaagtagtt ttgtgtggca 4380 tcacagtgat ttgtcatgaa aagccatata tgggggacat gctaaaatgg cttctgaatg 4440 aaatacgaca gcagagaaag atgccactga aatgctgaaa ttatctttgc tgagcagctt 4500 ttgaatgcta agggttccag tatgtgaccc aaagaaagag ttgtctcaac tccttggtac 4560 agggttcatt caaaccccca agctgtgaga gtgtgtttat ttttaatttt ttaaaaggta 4620 tttaatttcc aaccacactt cttatttttt tgaaaagaca attttccatt tcagtattac 4680 attttaccaa gaagtcactg ctttttaggt gtgttgcatc aatatttaaa taaaatccca 4740 gaaatgtatt ttaaagaatt tcaggtttga aaactcaaac caacaggaag atatcaaaaa 4800 aaaaaaaaaa a 4811 <210> 229 <211> 7843 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(7843) <223> ITGA2 mRNA <400> 229 agagaagccc tctggacagc ttctagagtg tgcaggttct cgtatccctc ggccaagggt 60 atcctctgca aacctctgca aacccagcgc aactacggtc ccccggtcag acccaggatg 120 gggccagaac ggacaggggc cgcgccgctg ccgctgctgc tggtgttagc gctcagtcaa 180 ggcattttaa attgttgttt ggcctacaat gttggtctcc cagaagcaaa aatattttcc 240 ggtccttcaa gtgaacagtt tggctatgca gtgcagcagt ttataaatcc aaaaggcaac 300 tggttactgg ttggttcacc ctggagtggc tttcctgaga accgaatggg agatgtgtat 360 aaatgtcctg ttgacctatc cactgccaca tgtgaaaaac taaatttgca aacttcaaca 420 agcattccaa atgttactga gatgaaaacc aacatgagcc tcggcttgat cctcaccagg 480 aacatgggaa ctggaggttt tctcacatgt ggtcctctgt gggcacagca atgtgggaat 540 cagtattaca caacgggtgt gtgttctgac atcagtcctg attttcagct ctcagccagc 600 ttctcacctg caactcagcc ctgcccttcc ctcatagatg ttgtggttgt gtgtgatgaa 660 tcaaatagta tttatccttg ggatgcagta aagaattttt tggaaaaatt tgtacaaggc 720 ctggatatag gccccacaaa gacacaggtg gggttaattc agtatgccaa taatccaaga 780 gttgtgttta acttgaacac atataaaacc aaagaagaaa tgattgtagc aacatcccag 840 acatcccaat atggtgggga cctcacaaac acattcggag caattcaata tgcaagaaaa 900 tatgcttatt cagcagcttc tggtgggcga cgaagtgcta cgaaagtaat ggtagttgta 960 actgacggtg aatcacatga tggttcaatg ttgaaagctg tgattgatca atgcaaccat 1020 gacaatatac tgaggtttgg catagcagtt cttgggtact taaacagaaa cgcccttgat 1080 actaaaaatt taataaaaga aataaaagca atcgctagta ttccaacaga aagatacttt 1140 ttcaatgtgt ctgatgaagc agctctacta gaaaaggctg ggacattagg agaacaaatt 1200 ttcagcattg aaggtactgt tcaaggagga gacaactttc agatggaaat gtcacaagtg 1260 ggattcagtg cagattactc ttctcaaaat gatattctga tgctgggtgc agtgggagct 1320 tttggctgga gtgggaccat tgtccagaag acatctcatg gccatttgat ctttcctaaa 1380 caagcctttg accaaattct gcaggacaga aatcacagtt catatttagg ttactctgtg 1440 gctgcaattt ctactggaga aagcactcac tttgttgctg gtgctcctcg ggcaaattat 1500 accggccaga tagtgctata tagtgtgaat gagaatggca atatcacggt tattcaggct 1560 caccgaggtg accagattgg ctcctatttt ggtagtgtgc tgtgttcagt tgatgtggat 1620 aaagacacca ttacagacgt gctcttggta ggtgcaccaa tgtacatgag tgacctaaag 1680 aaagaggaag gaagagtcta cctgtttact atcaaagagg gcattttggg tcagcaccaa 1740 tttcttgaag gccccgaggg cattgaaaac actcgatttg gttcagcaat tgcagctctt 1800 tcagacatca acatggatgg ctttaatgat gtgattgttg gttcaccact agaaaatcag 1860 aattctggag ctgtatacat ttacaatggt catcagggca ctatccgcac aaagtattcc 1920 cagaaaatct tgggatccga tggagccttt aggagccatc tccagtactt tgggaggtcc 1980 ttggatggct atggagattt aaatggggat tccatcaccg atgtgtctat tggtgccttt 2040 ggacaagtgg ttcaactctg gtcacaaagt attgctgatg tagctataga agcttcattc 2100 acaccagaaa aaatcacttt ggtcaacaag aatgctcaga taattctcaa actctgcttc 2160 agtgcaaagt tcagacctac taagcaaaac aatcaagtgg ccattgtata taacatcaca 2220 cttgatgcag atggattttc atccagagta acctccaggg ggttatttaa agaaaacaat 2280 gaaaggtgcc tgcagaagaa tatggtagta aatcaagcac agagttgccc cgagcacatc 2340 atttatatac aggagccctc tgatgttgtc aactctttgg atttgcgtgt ggacatcagt 2400 ctggaaaacc ctggcactag ccctgccctt gaagcctatt ctgagactgc caaggtcttc 2460 agtattcctt tccacaaaga ctgtggtgag gacggacttt gcatttctga tctagtccta 2520 gatgtccgac aaataccagc tgctcaagaa caacccttta ttgtcagcaa ccaaaacaaa 2580 aggttaacat tttcagtaac gctgaaaaat aaaagggaaa gtgcatacaa cactggaatt 2640 gttgttgatt tttcagaaaa cttgtttttt gcatcattct ccctgccggt tgatgggaca 2700 gaagtaacat gccaggtggc tgcatctcag aagtctgttg cctgcgatgt aggctaccct 2760 gctttaaaga gagaacaaca ggtgactttt actattaact ttgacttcaa tcttcaaaac 2820 cttcagaatc aggcgtctct cagtttccaa gccttaagtg aaagccaaga agaaaacaag 2880 gctgataatt tggtcaacct caaaattcct ctcctgtatg atgctgaaat tcacttaaca 2940 agatctacca acataaattt ttatgaaatc tcttcggatg ggaatgttcc ttcaatcgtg 3000 cacagttttg aagatgttgg tccaaaattc atcttctccc tgaaggtaac aacaggaagt 3060 gttccagtaa gcatggcaac tgtaatcatc cacatccctc agtataccaa agaaaagaac 3120 ccactgatgt acctaactgg ggtgcaaaca gacaaggctg gtgacatcag ttgtaatgca 3180 gatatcaatc cactgaaaat aggacaaaca tcttcttctg tatctttcaa aagtgaaaat 3240 ttcaggcaca ccaaagaatt gaactgcaga actgcttcct gtagtaatgt tacctgctgg 3300 ttgaaagacg ttcacatgaa aggagaatac tttgttaatg tgactaccag aatttggaac 3360 gggactttcg catcatcaac gttccagaca gtacagctaa cggcagctgc agaaatcaac 3420 acctataacc ctgagatata tgtgattgaa gataacactg ttacgattcc cctgatgata 3480 atgaaacctg atgagaaagc cgaagtacca acaggagtta taataggaag tataattgct 3540 ggaatccttt tgctgttagc tctggttgca attttatgga agctcggctt cttcaaaaga 3600 aaatatgaaa agatgaccaa aaatccagat gagattgatg agaccacaga gctcagtagc 3660 tgaaccagca gacctacctg cagtgggaac cggcagcatc ccagccaggg tttgctgttt 3720 gcgtgaatgg atttcttttt aaatcccata ttttttttat catgtcgtag gtaaactaac 3780 ctggtatttt aagagaaaac tgcaggtcag tttggaatga agaaattgtg gggggtgggg 3840 gaggtgcggg gggcaggtag ggaaataata gggaaaatac ctattttata tgatggggga 3900 aaaaaagtaa tctttaaact ggctggccca gagtttacat tctaatttgc attgtgtcag 3960 aaacatgaaa tgcttccaag catgacaact tttaaagaaa aatatgatac tctcagattt 4020 taagggggaa aactgttctc tttaaaatat ttgtctttaa acagcaacta cagaagtgga 4080 agtgcttgat atgtaagtac ttccacttgt gtatatttta atgaatattg atgttaacaa 4140 gaggggaaaa caaaacacag gttttttcaa tttatgctgc tcatccaaag ttgccacaga 4200 tgatacttcc aagtgataat tttatttata aactaggtaa aatttgttgt tggttccttt 4260 tagaccacgg ctgccccttc cacaccccat cttgctctaa tgatcaaaac atgcttgaat 4320 aactgagctt agagtatacc tcctatatgt ccatttaagt taggagaggg ggcgatatag 4380 agaataaggc acaaaatttt gtttaaaact cagaatataa catgtaaaat cccatctgct 4440 agaagcccat cctgtgccag aggaaggaaa aggaggaaat ttcctttctc ttttaggagg 4500 cacaacagtt ctcttctagg atttgtttgg ctgactggca gtaacctagt gaatttctga 4560 aagatgagta atttctttgg caaccttcct cctcccttac tgaaccactc tcccacctcc 4620 tggtggtacc attattatag aagccctcta cagcctgact ttctctccag cggtccaaag 4680 ttatcccctc ctttacccct catccaaagt tcccactcct tcaggacagc tgctgtgcat 4740 tagatattag gggggaaagt catctgttta atttacacac ttgcatgaat tactgtatat 4800 aaactcctta acttcaggga gctattttca tttagtgcta aacaagtaag aaaaataagc 4860 tcgagtgaat ttctaaatgt tggaatgtta tgggatgtaa acaatgtaaa gtaagacatc 4920 tcaggatttc accagaagtt acagatgagg cactggaagc caccaaatta gcaggtgcac 4980 cttctgtggc tgtcttgttt ctgaagtact taaacttcca caagagtgaa tttgacctag 5040 gcaagtttgt tcaaaaggta gatcctgaga tgatttggtc agattgggat aaggcccagc 5100 aatctgcatt ttaacaagca ccccagtcac taggatgcag atggaccaca ctttgagaaa 5160 caccacccat ttctactttt tgcaccttat tttctctgtt cctgagcccc cacattctct 5220 aggagaaact tagaggaaaa gggcacagac actacatatc taaagctttg gacaagtcct 5280 tgacctctat aaacttcaga gtcctcatta taaaatggga agactgagct ggagttcagc 5340 agtgatgctt ttagttttaa aagtctatga tctggacttc ctataataca aatacacaat 5400 cctccaagaa tttgacttgg aaaaaaatgt caaaggaaaa caggttatct gcccatgtgc 5460 atatggacaa ccttgactac cctggcctgg cccgtggtgg cagtccaggg ctatctgtac 5520 tgtttacaga attactttgt agttgacaac acaaaacaaa caaaaaaggc ataaaatgcc 5580 agcggtttat agaaaaaaca gcatggtatt ctccagttag gtatgccaga gtccaattct 5640 tttaacagct gtgagaattt gctgcttcat tccaacaaaa ttttatttaa aaaaaaaaaa 5700 aaaagactgg agaaactagt cattagcttg ataaagaata tttaacagct agtggtgctg 5760 gtgtgtacct gaagctccag ctacttgaga gactgagaca ggaagatcgc ttgagcccag 5820 gagttcaagt ccagcctaag caacatagca agaccctgtc tcaaaaaaat gactatttaa 5880 aaagacaatg tggccaggca cggtggctca cacctgtaat cccaacactt tgggaggctg 5940 aggccggtgg atcacgaggt caggagtttg agactagcct ggccaacatg gtgaaacccc 6000 atctctaata atataaaaat tagctgggcg tagtagcagg tgcctgtaat cccagttact 6060 cgggaagctg aggcaggaga atcacttgaa cccgggaggc agaggtttca gtgagccgag 6120 atcgcgccac tgcactccag cctgggtgac agggcaagac tctgtctcaa acaaacaaac 6180 aaaaaaaaag ttagtactgt atatgtaaat actagctttt caatgtgcta tacaaacaat 6240 tatagcacat ccttcctttt actctgtctc acctccttta ggtgagtact tccttaaata 6300 agtgctaaac atacatatac ggaacttgaa agctttggtt agccttgcct taggtaatca 6360 gcctagttta cactgtttcc agggagtagt tgaattacta taaaccatta gccacttgtc 6420 tctgcaccat ttatcacacc aggacagggt ctctcaacct gggcgctact gtcatttggg 6480 gccaggtgat tcttccttgc aggggctgtc ctgtaccttg taggacagca gccctgtcct 6540 agaaggtatg tttagcagca ttcctggcct ctagctaccc gatgccagag catgctcccc 6600 ccgcagtcat gacaatcaaa aaatgtctcc agacattgtc aaatgcctcc tggggggcag 6660 tatttctcaa gcacttttaa gcaaaggtaa gtattcatac aagaaattta gggggaaaaa 6720 acattgttta aataaaagct atgtgttcct attcaacaat atttttgctt taaaagtaag 6780 tagagggcat aaaagatgtc atattcaaat ttccatttca taaatggtgt acagacaagg 6840 tctatagaat gtggtaaaaa cttgactgca acacaaggct tataaaatag taagatagta 6900 aaatagctta tgaagaaact acagagattt aaaattgtgc atgactcatt tcagcagcaa 6960 aataagaact cctaactgaa cagaaatttt tctacctagc aatgttattc ttgtaaaata 7020 gttacctatt aaaactgtga agagtaaaac taaagccaat ttattatagt cacacaagtg 7080 attatactaa aaattattat aaaggttata attttataat gtatttacct gtcctgatat 7140 atagctataa cccaatatat gaaaatctca aaaattaaga catcatcata cagaaggcag 7200 gattccttaa actgagatcc ctgatccatc tttaatattt caatttgcac acataaaaca 7260 atgccctttt gtgtacattc aggcataccc attttaatca atttgaaagg ttaatttaaa 7320 cctctagagg tgaatgagaa acatggggga aaagtatgaa ataggtgaaa atcttaacta 7380 tttctttgaa ctctaaagac tgaaactgta gccattatgt aaataaagtt tcatatgtac 7440 ctgtttattt tggcagatta agtcaaaata tgaatgtata tattgcataa ctatgttaga 7500 attgtatata ttttaaagaa attgtcttgg atattttcct ttatacataa tagataagtc 7560 ttttttcaaa tgtggtgttt gatgtttttg attaaatgtg ttttgcctct ttccacaaaa 7620 actgtaaaaa taaatgcatg tttgtacaaa aagttgcaga attcatttga tttatgagaa 7680 acaaaaatta aattgtagtc aacagttagt agtttttctc atatccaagt ataacaaaca 7740 gaaaagtttc attattgtaa cccacttttt tcataccaca ttattgaata ttgttacaat 7800 tgttttgaaa ataaagccat tttctttggg cttttataag tta 7843 <210> 230 <211> 4889 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4889) <223> ITGA3 mRNA <400> 230 agatccgccg cgaagccggg atcgaaggcg acagcgcggc caagggggcg cggccgggac 60 aagctggggg ccggttgccc ggggcaggga cggcggcgac ccggccgctg gggaggcagg 120 aagatagacc cacggatctt aggaagggat ccgagagcgc agctgtgaaa ctggctgggg 180 ctgggggcac gaaaccgatc agcgctacgg agcgcagcgg ccggcgggtt ccagtgtcct 240 ccggcggcgc ggggagcagg tgaacaggtc ctcacgccca gctccgcgcc ctcacgcgct 300 ctcgccggga ccccgcttcc gctggcagcc atgggccccg gccccagccg cgcgccccgc 360 gccccacgcc tgatgctctg tgcgctcgcc ttgatggtgg cggccggcgg ctgcgtcgtc 420 tccgccttca acctggatac ccgattcctg gtagtgaagg aggccgggaa cccgggcagc 480 ctcttcggct actcggtcgc cctccatcgg cagacagagc ggcagcagcg ctacctgctc 540 ctggctggtg ccccccggga gctcgctgtg cccgatggct acaccaaccg gactggtgct 600 gtgtacctgt gcccactcac tgcccacaag gatgactgtg agcggatgaa catcacagtg 660 aaaaatgacc ctggccatca cattattgag gacatgtggc ttggagtgac tgtggccagc 720 cagggccctg caggcagagt tctggtctgt gcccaccgct acacccaggt gctgtggtca 780 gggtcagaag accagcggcg catggtgggc aagtgctacg tgcgaggcaa tgacctagag 840 ctggactcca gtgatgactg gcagacctac cacaacgaga tgtgcaatag caacacagac 900 tacctggaga cgggcatgtg ccagctgggc accagcggtg gcttcaccca gaacactgtg 960 tacttcggcg cccccggtgc ctacaactgg aaaggaaaca gctacatgat tcagcgcaag 1020 gagtgggact tatctgagta tagttacaag gacccagagg accaaggaaa cctctatatt 1080 gggtacacga tgcaggtagg cagcttcatc ctgcacccca aaaacatcac cattgtgaca 1140 ggtgccccac ggcaccgaca tatgggcgcg gtgttcttgc tgagccagga ggcaggcgga 1200 gacctgcgga ggaggcaggt gctggagggc tcgcaggtgg gcgcctattt tggcagcgcc 1260 attgccctgg cagacctgaa caatgatggg tggcaggacc tcctggtggg cgccccctac 1320 tacttcgaga ggaaagagga agtagggggt gccatctatg tcttcatgaa ccaggcggga 1380 acctccttcc ctgctcaccc ctcactcctt cttcatggcc ccagtggctc tgcctttggt 1440 ttatctgtgg ccagcattgg tgacatcaac caggatggat ttcaggatat tgctgtggga 1500 gctccgtttg aaggcttggg caaagtgtac atctatcaca gtagctctaa ggggctcctt 1560 agacagcccc agcaggtaat ccatggagag aagctgggac tgcctgggtt ggccaccttc 1620 ggctattccc tcagtgggca gatggatgtg gatgagaact tctacccaga ccttctagtg 1680 ggaagcctgt cagaccacat tgtgctgctg cgggcccggc ccgtcatcaa catcgtccac 1740 aagaccttgg tgcccaggcc agctgtgctg gaccctgcac tttgcacggc cacctcttgt 1800 gtgcaagtgg agctgtgctt tgcttacaac cagagtgccg ggaaccccaa ctacaggcga 1860 aacatcaccc tggcctacac tctggaggct gacagggacc gccggccgcc ccggctccgc 1920 tttgccggca gtgagtccgc tgtcttccac ggcttcttct ccatgcccga gatgcgctgc 1980 cagaagctgg agctgctcct gatggacaac ctccgtgaca aactccgccc catcatcatc 2040 tccatgaact actctttacc tttgcggatg cccgatcgcc cccggctggg gctgcggtcc 2100 ctggacgcct acccgatcct caaccaggca caggctctgg agaaccacac tgaggtccag 2160 ttccagaagg agtgcgggcc tgacaacaag tgtgagagca acttgcagat gcgggcagcc 2220 ttcgtgtcag agcagcagca gaagctgagc aggctccagt acagcagaga cgtccggaaa 2280 ttgctcctga gcatcaacgt gacgaacacc cggacctcgg agcgctccgg ggaggacgcc 2340 cacgaggcgc tgctcaccct ggtggtgcct cccgccctgc tgctgtcctc agtgcgcccc 2400 cccggggcct gccaagctaa tgagaccatc ttttgcgagc tggggaaccc cttcaaacgg 2460 aaccagagga tggagctgct catcgccttt gaggtcatcg gggtgaccct gcacacaagg 2520 gaccttcagg tgcagctgca gctctccacg tcgagtcacc aggacaacct gtggcccatg 2580 atcctcactc tgctggtgga ctatacactc cagacctcgc ttagcatggt aaatcaccgg 2640 ctacaaagct tctttggggg gacagtgatg ggtgagtctg gcatgaaaac tgtggaggat 2700 gtaggaagcc ccctcaagta tgaattccag gtgggcccaa tgggggaggg gctggtgggc 2760 ctggggaccc tggtcctagg tctggagtgg ccctacgaag tcagcaatgg caagtggctg 2820 ctgtatccca cggagatcac cgtccatggc aatgggtcct ggccctgccg accacctgga 2880 gaccttatca accctctcaa cctcactctt tctgaccctg gggacaggcc atcatcccca 2940 cagcgcaggc ggcgacagct ggatccaggg ggaggccagg gccccccacc tgtcactctg 3000 gctgctgcca aaaaagccaa gtctgagact gtgctgacct gtgccacagg gcgtgcccac 3060 tgtgtgtggc tagagtgccc catccctgat gcccccgttg tcaccaacgt gactgtgaag 3120 gcacgagtgt ggaacagcac cttcatcgag gattacagag actttgaccg agtccgggta 3180 aatggctggg ctaccctatt cctccgaacc agcatcccca ccatcaacat ggagaacaag 3240 accacgtggt tctctgtgga cattgactcg gagctggtgg aggagctgcc ggccgaaatc 3300 gagctgtggc tggtgctggt ggccgtgggt gcagggctgc tgctgctggg gctgatcatc 3360 ctcctgctgt ggaagtgcgg cttcttcaag cgagcccgca ctcgcgccct gtatgaagct 3420 aagaggcaga aggcggagat gaagagccag ccgtcagaga cagagaggct gaccgacgac 3480 tactgagggg gcagcccccc gcccccggcc cacctggtgt gacttcttta agcggacccg 3540 ctattatcag atcatgccca agtaccacgc agtgcggatc cgggaggagg agcgctaccc 3600 acctccaggg agcaccctgc ccaccaagaa gcactgggtg accagctggc agactcggga 3660 ccaatactac tgacgtcctc cctgatccca ccccctcctc ccccagtgtc ccctttcttc 3720 ctatttatca taagttatgc ctctgacagt ccacaggggc caccaccttt ggctggtagc 3780 agcaggctca ggcacataca cctcgtcaag agcatgcaca tgctgtctgg ccctggggat 3840 cttcccacag gagggccagc gctgtggacc ttacaacgcc gagtgcactg cattcctgtg 3900 ccctagatgc acgtggggcc cactgctcgt ggactgtgct ggtgcatcac ggatggtgca 3960 tgggctcgcc gtgtctcagc ctctgccagc gccaaaacaa gccaaagagc ctcccaccag 4020 agccgggagg aaaaggcccc tgcaatgtgg tgacacctcc ccctttcaca ctggatccat 4080 cttgagccac agtcactgga ttgactttgc tgtcaaaact actgacaggg agcagccccc 4140 gggccgctgg ctggtgggcc cccaatgaca cccatgccag agaggtgggg atcctgccta 4200 aggttgtcta cgggggcact tggaggacct ggcgtgctca gacccaacag caaaggaact 4260 agaaagaagg acccagaacg gcttgctttc ctgcatctct gtgaagcctc tctccttggc 4320 cacagactga actcgcaggg aatgcagcag gaaggaacaa agacaggcaa acggcaacgt 4380 agcctgggct cactgtgctg gggcacggcg ggatcctcca cagagaggag gggaccaatt 4440 ctggacagac agatgttggg aggatacaga ggagatgcca cttctcactc accactacca 4500 gccagcctca gaaggcccca gagagaccct gcaagaccac ggagggagcg acacttgaat 4560 gtagaatagg cagggggccc tgccccaccc catccagcca gaccccacgc tgaccatgcg 4620 tcaggggcct agaggtggag ttcttagcta tccttggctt tcagagccag cctggctctg 4680 ccccctcccc catgggctgt gtcctaaggc ccatttgaga agctgaggct agttccagaa 4740 aacctctcct gacccctgcc tgttggcagg cccactcccc agccccagcc ccttccatgg 4800 tactgtagca ggggaattcc ctccccctcc ttgtgccttc tttgtatata ggcttctcac 4860 ggcgaccaat aaacagctcc cagtttgta 4889 <210> 231 <211> 6781 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6781) <223> ITGA4 mRNA <400> 231 gaagcagcgc gagcacccga agctcccggc tggcggcaga aaccgggagt ggggccgggc 60 gagtgcgcgg catcccaggc cggcccgaac gctccgcccg cggtgggccg acttcccctc 120 ctcttccctc tctccttcct ttagcccgct ggcgccggac acgctgcgcc tcatctcttg 180 gggcgttctt ccccgttggc caaccgtcgc atcccgtgca actttggggt agtggccgtt 240 tagtgttgaa tgttccccac cgagagcgca tggcttggga agcgaggcgc gaacccggcc 300 cccgaagggc cgccgtccgg gagacggtga tgctgttgct gtgcctgggg gtcccgaccg 360 gccgccccta caacgtggac actgagagcg cgctgcttta ccagggcccc cacaacacgc 420 tgttcggcta ctcggtcgtg ctgcacagcc acggggcgaa ccgatggctc ctagtgggtg 480 cgcccactgc caactggctc gccaacgctt cagtgatcaa tcccggggcg atttacagat 540 gcaggatcgg aaagaatccc ggccagacgt gcgaacagct ccagctgggt agccctaatg 600 gagaaccttg tggaaagact tgtttggaag agagagacaa tcagtggttg ggggtcacac 660 tttccagaca gccaggagaa aatggatcca tcgtgacttg tgggcataga tggaaaaata 720 tattttacat aaagaatgaa aataagctcc ccactggtgg ttgctatgga gtgccccctg 780 atttacgaac agaactgagt aaaagaatag ctccgtgtta tcaagattat gtgaaaaaat 840 ttggagaaaa ttttgcatca tgtcaagctg gaatatccag tttttacaca aaggatttaa 900 ttgtgatggg ggccccagga tcatcttact ggactggctc tctttttgtc tacaatataa 960 ctacaaataa atacaaggct tttttagaca aacaaaatca agtaaaattt ggaagttatt 1020 taggatattc agtcggagct ggtcattttc ggagccagca tactaccgaa gtagtcggag 1080 gagctcctca acatgagcag attggtaagg catatatatt cagcattgat gaaaaagaac 1140 taaatatctt acatgaaatg aaaggtaaaa agcttggatc gtactttgga gcttctgtct 1200 gtgctgtgga cctcaatgca gatggcttct cagatctgct cgtgggagca cccatgcaga 1260 gcaccatcag agaggaagga agagtgtttg tgtacatcaa ctctggctcg ggagcagtaa 1320 tgaatgcaat ggaaacaaac ctcgttggaa gtgacaaata tgctgcaaga tttggggaat 1380 ctatagttaa tcttggcgac attgacaatg atggctttga agatgttgct atcggagctc 1440 cacaagaaga tgacttgcaa ggtgctattt atatttacaa tggccgtgca gatgggatct 1500 cgtcaacctt ctcacagaga attgaaggac ttcagatcag caaatcgtta agtatgtttg 1560 gacagtctat atcaggacaa attgatgcag ataataatgg ctatgtagat gtagcagttg 1620 gtgcttttcg gtctgattct gctgtcttgc taaggacaag acctgtagta attgttgacg 1680 cttctttaag ccaccctgag tcagtaaata gaacgaaatt tgactgtgtt gaaaatggat 1740 ggccttctgt gtgcatagat ctaacacttt gtttctcata taagggcaag gaagttccag 1800 gttacattgt tttgttttat aacatgagtt tggatgtgaa cagaaaggca gagtctccac 1860 caagattcta tttctcttct aatggaactt ctgacgtgat tacaggaagc atacaggtgt 1920 ccagcagaga agctaactgt agaacacatc aagcatttat gcggaaagat gtgcgggaca 1980 tcctcacccc aattcagatt gaagctgctt accaccttgg tcctcatgtc atcagtaaac 2040 gaagtacaga ggaattccca ccacttcagc caattcttca gcagaagaaa gaaaaagaca 2100 taatgaaaaa aacaataaac tttgcaaggt tttgtgccca tgaaaattgt tctgctgatt 2160 tacaggtttc tgcaaagatt gggtttttga agccccatga aaataaaaca tatcttgctg 2220 ttgggagtat gaagacattg atgttgaatg tgtccttgtt taatgctgga gatgatgcat 2280 atgaaacgac tctacatgtc aaactacccg tgggtcttta tttcattaag attttagagc 2340 tggaagagaa gcaaataaac tgtgaagtca cagataactc tggcgtggta caacttgact 2400 gcagtattgg ctatatatat gtagatcatc tctcaaggat agatattagc tttctcctgg 2460 atgtgagctc actcagcaga gcggaagagg acctcagtat cacagtgcat gctacctgtg 2520 aaaatgaaga ggaaatggac aatctaaagc acagcagagt gactgtagca atacctttaa 2580 aatatgaggt taagctgact gttcatgggt ttgtaaaccc aacttcattt gtgtatggat 2640 caaatgatga aaatgagcct gaaacgtgca tggtggagaa aatgaactta actttccatg 2700 ttatcaacac tggcaatagt atggctccca atgttagtgt ggaaataatg gtaccaaatt 2760 cttttagccc ccaaactgat aagctgttca acattttgga tgtccagact actactggag 2820 aatgccactt tgaaaattat caaagagtgt gtgcattaga gcagcaaaag agtgcaatgc 2880 agaccttgaa aggcatagtc cggttcttgt ccaagactga taagaggcta ttgtactgca 2940 taaaagctga tccacattgt ttaaatttct tgtgtaattt tgggaaaatg gaaagtggaa 3000 aagaagccag tgttcatatc caactggaag gccggccatc cattttagaa atggatgaga 3060 cttcagcact caagtttgaa ataagagcaa caggttttcc agagccaaat ccaagagtaa 3120 ttgaactaaa caaggatgag aatgttgcgc atgttctact ggaaggacta catcatcaaa 3180 gacccaaacg ttatttcacc atagtgatta tttcaagtag cttgctactt ggacttattg 3240 tacttctatt gatctcatat gttatgtgga aggctggctt ctttaaaaga caatacaaat 3300 ctatcctaca agaagaaaac agaagagaca gttggagtta tatcaacagt aaaagcaatg 3360 atgattaagg acttctttca aattgagaga atggaaaaca gactcaggtt gtagtaaaga 3420 aatttaaaag acactgttta caagaaaaaa tgaattttgt ttggacttct tttactcatg 3480 atcttgtgac atattatgtc ttcatgcaag gggaaaatct cagcaatgat tactctttga 3540 gatagaagaa ctgcaaaggt aataatacag ccaaagataa tctctcagct tttaaatggg 3600 tagagaaaca ctaaagcatt caatttattc aagaaaagta agcccttgaa gatatcttga 3660 aatgaaagta taactgagtt aaattatact ggagaagtct tagacttgaa atactactta 3720 ccatatgtgc ttgcctcagt aaaatgaacc ccactgggtg ggcagaggtt catttcaaat 3780 acatctttga tacttgttca aaatatgttc tttaaaaata taatttttta gagagctgtt 3840 cccaaatttt ctaacgagtg gaccattatc actttaaagc cctttattta taatacattt 3900 cctacgggct gtgttccaac aaccattttt tttcagcaga ctatgaatat tatagtatta 3960 taggccaaac tggcaaactt cagactgaac atgtacactg gtttgagctt agtgaaatta 4020 cttctggata attatttttt tataattatg gatttcacca tctttctttc tgtatatata 4080 catgtgtttt tatgtaggta tatatttacc attcttccta tctattcttc ctataacaca 4140 cctttatcaa gcatacccag gagtaatctt caaatctttt gttatattct gaaacaaaag 4200 attgtgagtg ttgcacttta cctgatacac gctgatttag aaaatacaga aaccatacct 4260 cactaataac tttaaaatca aagctgtgca aagactaggg ggcctatact tcatatgtat 4320 tatgtactat gtaaaatatt gactatcaca caactatttc cttggatgta attctttgtt 4380 accctttaca agtataagtg ttaccttaca tggaaacgaa gaaacaaaat tcataaattt 4440 aaattcataa atttagctga aagatactga ttcaatttgt atacagtgaa tataaatgag 4500 acgacagcaa aattttcatg aaatgtaaaa tatttttata gtttgttcat actatatgag 4560 gttctatttt aaatgacttt ctggatttta aaaaatttct ttaaatacaa tcatttttgt 4620 aatatttatt ttatgcttat gatctagata attgcagaat atcattttat ctgactctgc 4680 cttcataaga gagctgtggc cgaattttga acatctgtta tagggagtga tcaaattaga 4740 aggcaatgtg gaaaaacaat tctgggaaag atttctttat atgaagtccc tgccactagc 4800 cagccatcct aattgatgaa agttatctgt tcacaggcct gcagtgatgg tgaggaatgt 4860 tctgagattt gcgaaggcat ttgagtagtg aaatgtaagc acaaaacctc ctgaacccag 4920 agtgtgtata cacaggaata aactttatga catttatgta tttttaaaaa actttgtatc 4980 gttataaaaa ggctagtcat tctttcagga gaacatctag gatcatagat gaaaaatcaa 5040 gccccgattt agaactgtct tctccaggat ggtctctaag gaaatttaca tttggttctt 5100 tcctactcag aactactcag aaacaactat atatttcagg ttatctgagc acagtgaaag 5160 cagagtacta tggttgtcca acacaggcct ctcagataca aggggaacac aattacatat 5220 tgggctagat tttgcccagt tcaaaatagt atttgttatc aacttacttt gttacttgta 5280 tcatgaattt taaaacccta ccactttaag aagacaggga tgggttattc ttttttggca 5340 ggtaggctat ataactatgt gattttgaaa tttaactgct ctggattagg gagcagtgaa 5400 tcaaggcaga cttatgaaat ctgtattata tttgtaacag aatataggaa atttaacata 5460 attgatgagc tcaaatcctg aaaaatgaaa gaatccaaat tatttcagaa ttatctaggt 5520 taaatattga tgtattatga tggttgcaaa gtttttttgt gtgtccaata aacacattgt 5580 aaaaaaaaga atttgaattg atatctaaaa acagaatttg aattgatatt tcatcttgac 5640 ttttaaagcc ctagaggcta attgttagta acatcaattt ctattaggat atccgtttgg 5700 ccacacagca ggaggttaga gcaatggagc attactgagt tcctccccct gtcagatcag 5760 cagcagcatt agattctcat agaagtgcga accatatggt gaactggtat gtgagggatc 5820 tagagtgcca tgttcctcaa gagaatctaa tgcctgatga tctgaggtgg aacagttcat 5880 cctgaaacca ttcccccatc cacggaaaaa ttgtcttcca tgaaactggt cccaaaaagg 5940 gtggggacca caggtttaaa gcatggccac atttctttat attaaaattc tagtttgtac 6000 atttctttta gaaacaatta catgttactt tggaatcatt tcttccatgc ttcctccata 6060 aagactgata agtcttggat gcaatctgta aagaaaatac attatttcat caacttattt 6120 tgttgttttt cacatacacc taataagtat ggtacacaat gccaatgcca aatacaaatt 6180 gataacaaac acagcattcc caacagagct gtaatctaga aaactgagaa ggtctgattg 6240 ataaatcatc aacaacaata attgctctaa aacctcctta actgacttcc ttgattgtcc 6300 aatgctctcc attacctctg taaaacagtc agttatgcct ctagaacacc catgtctagt 6360 gggcacccct gcatgcttct tctaaccact gagtgtcaca atgcctacca agaatgcgtt 6420 tgcaggttcc taaacctgtt tataccagtt gctatgtaaa attgttccca agggaagttg 6480 aatgctctgt aaaggcctaa taaaagcaaa ttactgaaca aaacatgtta cagtaattat 6540 gagtgagagg aaactaagat ggaaggataa aaatctaaca ctttactatt cagatggctc 6600 cactaaaaga tttaagatct tgatccattt ttaaaaatcc aaaatggaag ttgtagacat 6660 tatctgtagt ttatgcacaa caataaatta gaaagccaat gtagacacgc ataaccaaag 6720 aaaatgcctt gggtctacat aacagttgaa taaatgtaaa gttgcttttt atttattgaa 6780 a 6781 <210> 232 <211> 4267 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4267) <223> ITGA5 mRNA <400> 232 attcgcctct gggaggttta ggaagcggct ccgggtcggt ggccccagga cagggaagag 60 cgggcgctat ggggagccgg acgccagagt cccctctcca cgccgtgcag ctgcgctggg 120 gcccccggcg ccgacccccg ctgctgccgc tgctgttgct gctgctgccg ccgccaccca 180 gggtcggggg cttcaactta gacgcggagg ccccagcagt actctcgggg cccccgggct 240 ccttcttcgg attctcagtg gagttttacc ggccgggaac agacggggtc agtgtgctgg 300 tgggagcacc caaggctaat accagccagc caggagtgct gcagggtggt gctgtctacc 360 tctgtccttg gggtgccagc cccacacagt gcacccccat tgaatttgac agcaaaggct 420 ctcggctcct ggagtcctca ctgtccagct cagagggaga ggagcctgtg gagtacaagt 480 ccttgcagtg gttcggggca acagttcgag cccatggctc ctccatcttg gcatgcgctc 540 cactgtacag ctggcgcaca gagaaggagc cactgagcga ccccgtgggc acctgctacc 600 tctccacaga taacttcacc cgaattctgg agtatgcacc ctgccgctca gatttcagct 660 gggcagcagg acagggttac tgccaaggag gcttcagtgc cgagttcacc aagactggcc 720 gtgtggtttt aggtggacca ggaagctatt tctggcaagg ccagatcctg tctgccactc 780 aggagcagat tgcagaatct tattaccccg agtacctgat caacctggtt caggggcagc 840 tgcagactcg ccaggccagt tccatctatg atgacagcta cctaggatac tctgtggctg 900 ttggtgaatt cagtggtgat gacacagaag actttgttgc tggtgtgccc aaagggaacc 960 tcacttacgg ctatgtcacc atccttaatg gctcagacat tcgatccctc tacaacttct 1020 caggggaaca gatggcctcc tactttggct atgcagtggc cgccacagac gtcaatgggg 1080 acgggctgga tgacttgctg gtgggggcac ccctgctcat ggatcggacc cctgacgggc 1140 ggcctcagga ggtgggcagg gtctacgtct acctgcagca cccagccggc atagagccca 1200 cgcccaccct taccctcact ggccatgatg agtttggccg atttggcagc tccttgaccc 1260 ccctggggga cctggaccag gatggctaca atgatgtggc catcggggct ccctttggtg 1320 gggagaccca gcagggagta gtgtttgtat ttcctggggg cccaggaggg ctgggctcta 1380 agccttccca ggttctgcag cccctgtggg cagccagcca caccccagac ttctttggct 1440 ctgcccttcg aggaggccga gacctggatg gcaatggata tcctgatctg attgtggggt 1500 cctttggtgt ggacaaggct gtggtataca ggggccgccc catcgtgtcc gctagtgcct 1560 ccctcaccat cttccccgcc atgttcaacc cagaggagcg gagctgcagc ttagagggga 1620 accctgtggc ctgcatcaac cttagcttct gcctcaatgc ttctggaaaa cacgttgctg 1680 actccattgg tttcacagtg gaacttcagc tggactggca gaagcagaag ggaggggtac 1740 ggcgggcact gttcctggcc tccaggcagg caaccctgac ccagaccctg ctcatccaga 1800 atggggctcg agaggattgc agagagatga agatctacct caggaacgag tcagaatttc 1860 gagacaaact ctcgccgatt cacatcgctc tcaacttctc cttggacccc caagccccag 1920 tggacagcca cggcctcagg ccagccctac attatcagag caagagccgg atagaggaca 1980 aggctcagat cttgctggac tgtggagaag acaacatctg tgtgcctgac ctgcagctgg 2040 aagtgtttgg ggagcagaac catgtgtacc tgggtgacaa gaatgccctg aacctcactt 2100 tccatgccca gaatgtgggt gagggtggcg cctatgaggc tgagcttcgg gtcaccgccc 2160 ctccagaggc tgagtactca ggactcgtca gacacccagg gaacttctcc agcctgagct 2220 gtgactactt tgccgtgaac cagagccgcc tgctggtgtg tgacctgggc aaccccatga 2280 aggcaggagc cagtctgtgg ggtggccttc ggtttacagt ccctcatctc cgggacacta 2340 agaaaaccat ccagtttgac ttccagatcc tcagcaagaa tctcaacaac tcgcaaagcg 2400 acgtggtttc ctttcggctc tccgtggagg ctcaggccca ggtcaccctg aacggtgtct 2460 ccaagcctga ggcagtgcta ttcccagtaa gcgactggca tccccgagac cagcctcaga 2520 aggaggagga cctgggacct gctgtccacc atgtctatga gctcatcaac caaggcccca 2580 gctccattag ccagggtgtg ctggaactca gctgtcccca ggctctggaa ggtcagcagc 2640 tcctatatgt gaccagagtt acgggactca actgcaccac caatcacccc attaacccaa 2700 agggcctgga gttggatccc gagggttccc tgcaccacca gcaaaaacgg gaagctccaa 2760 gccgcagctc tgcttcctcg ggacctcaga tcctgaaatg cccggaggct gagtgtttca 2820 ggctgcgctg tgagctcggg cccctgcacc aacaagagag ccaaagtctg cagttgcatt 2880 tccgagtctg ggccaagact ttcttgcagc gggagcacca gccatttagc ctgcagtgtg 2940 aggctgtgta caaagccctg aagatgccct accgaatcct gcctcggcag ctgccccaaa 3000 aagagcgtca ggtggccaca gctgtgcaat ggaccaaggc agaaggcagc tatggcgtcc 3060 cactgtggat catcatccta gccatcctgt ttggcctcct gctcctaggt ctactcatct 3120 acatcctcta caagcttgga ttcttcaaac gctccctccc atatggcacc gccatggaaa 3180 aagctcagct caagcctcca gccacctctg atgcctgagt cctcccaatt tcagactccc 3240 attcctgaag aaccagtccc cccaccctca ttctactgaa aaggaggggt ctgggtactt 3300 cttgaaggtg ctgacggcca gggagaagct cctctcccca gcccagagac atacttgaag 3360 ggccagagcc aggggggtga ggagctgggg atccctcccc cccatgcact gtgaaggacc 3420 cttgtttaca cataccctct tcatggatgg gggaactcag atccagggac agaggcccca 3480 gcctccctga agcctttgca ttttggagag tttcctgaaa caacttggaa agataactag 3540 gaaatccatt cacagttctt tgggccagac atgccacaag gacttcctgt ccagctccaa 3600 cctgcaaaga tctgtcctca gccttgccag agatccaaaa gaagccccca gctaagaacc 3660 tggaacttgg ggagttaaga cctggcagct ctggacagcc ccaccctggt gggccaacaa 3720 agaacactaa ctatgcatgg tgccccagga ccagctcagg acagatgcca cacaaggata 3780 gatgctggcc cagggcccag agcccagctc caaggggaat cagaactcaa atggggccag 3840 atccagcctg gggtctggag ttgatctgga acccagactc agacattggc acctaatcca 3900 ggcagatcca ggactatatt tgggcctgct ccagacctga tcctggaggc ccagttcacc 3960 ctgatttagg agaagccagg aatttcccag gaccctgaag gggccatgat ggcaacagat 4020 ctggaacctc agcctggcca gacacaggcc ctccctgttc cccagagaaa ggggagccca 4080 ctgtcctggg cctgcagaat ttgggttctg cctgccagct gcactgatgc tgcccctcat 4140 ctctctgccc aacccttccc tcaccttggc accagacacc caggacttat ttaaactctg 4200 ttgcaagtgc aataaatctg acccagtgcc cccactgacc agaactagaa aaaaaaaaaa 4260 aaaaaaa 4267 <210> 233 <211> 7039 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(7039) <223> ITGAV mRNA <400> 233 agtccccagc ctcagacgct gcgtggagcg gcggagccgg agggaagcaa aggaccgtct 60 gcgctgctgt ccccgccccg cgcgctctgc gcccctcgtc cctggcggtc gctccgaagc 120 tcagccctct tgcctgcccc ggagctgtcc cgggctagcc gagaagagag cggccggcaa 180 gtttgggcgc gcgcaggcgg cgggccgcgg gcactgggcg cctcgctggg gcggggggag 240 gtggctaccg ctcccggctt ggcgtcccgc gcgcacttcg gcgatggctt ttccgccgcg 300 gcgacggctg cgcctcggtc cccgcggcct cccgcttctt ctctcgggac tcctgctacc 360 tctgtgccgc gccttcaacc tagacgtgga cagtcctgcc gagtactctg gccccgaggg 420 aagttacttc ggcttcgccg tggatttctt cgtgcccagc gcgtcttccc ggatgtttct 480 tctcgtggga gctcccaaag caaacaccac ccagcctggg attgtggaag gagggcaggt 540 cctcaaatgt gactggtctt ctacccgccg gtgccagcca attgaatttg atgcaacagg 600 caatagagat tatgccaagg atgatccatt ggaatttaag tcccatcagt ggtttggagc 660 atctgtgagg tcgaaacagg ataaaatttt ggcctgtgcc ccattgtacc attggagaac 720 tgagatgaaa caggagcgag agcctgttgg aacatgcttt cttcaagatg gaacaaagac 780 tgttgagtat gctccatgta gatcacaaga tattgatgct gatggacagg gattttgtca 840 aggaggattc agcattgatt ttactaaagc tgacagagta cttcttggtg gtcctggtag 900 cttttattgg caaggtcagc ttatttcgga tcaagtggca gaaatcgtat ctaaatacga 960 ccccaatgtt tacagcatca agtataataa ccaattagca actcggactg cacaagctat 1020 ttttgatgac agctatttgg gttattctgt ggctgtcgga gatttcaatg gtgatggcat 1080 agatgacttt gtttcaggag ttccaagagc agcaaggact ttgggaatgg tttatattta 1140 tgatgggaag aacatgtcct ccttatacaa ttttactggc gagcagatgg ctgcatattt 1200 cggattttct gtagctgcca ctgacattaa tggagatgat tatgcagatg tgtttattgg 1260 agcacctctc ttcatggatc gtggctctga tggcaaactc caagaggtgg ggcaggtctc 1320 agtgtctcta cagagagctt caggagactt ccagacgaca aagctgaatg gatttgaggt 1380 ctttgcacgg tttggcagtg ccatagctcc tttgggagat ctggaccagg atggtttcaa 1440 tgatattgca attgctgctc catatggggg tgaagataaa aaaggaattg tttatatctt 1500 caatggaaga tcaacaggct tgaacgcagt cccatctcaa atccttgaag ggcagtgggc 1560 tgctcgaagc atgccaccaa gctttggcta ttcaatgaaa ggagccacag atatagacaa 1620 aaatggatat ccagacttaa ttgtaggagc ttttggtgta gatcgagcta tcttatacag 1680 ggccagacca gttatcactg taaatgctgg tcttgaagtg taccctagca ttttaaatca 1740 agacaataaa acctgctcac tgcctggaac agctctcaaa gtttcctgtt ttaatgttag 1800 gttctgctta aaggcagatg gcaaaggagt acttcccagg aaacttaatt tccaggtgga 1860 acttcttttg gataaactca agcaaaaggg agcaattcga cgagcactgt ttctctacag 1920 caggtcccca agtcactcca agaacatgac tatttcaagg gggggactga tgcagtgtga 1980 ggaattgata gcgtatctgc gggatgaatc tgaatttaga gacaaactca ctccaattac 2040 tatttttatg gaatatcggt tggattatag aacagctgct gatacaacag gcttgcaacc 2100 cattcttaac cagttcacgc ctgctaacat tagtcgacag gctcacattc tacttgactg 2160 tggtgaagac aatgtctgta aacccaagct ggaagtttct gtagatagtg atcaaaagaa 2220 gatctatatt ggggatgaca accctctgac attgattgtt aaggctcaga atcaaggaga 2280 aggtgcctac gaagctgagc tcatcgtttc cattccactg caggctgatt tcatcggggt 2340 tgtccgaaac aatgaagcct tagcaagact ttcctgtgca tttaagacag aaaaccaaac 2400 tcgccaggtg gtatgtgacc ttggaaaccc aatgaaggct ggaactcaac tcttagctgg 2460 tcttcgtttc agtgtgcacc agcagtcaga gatggatact tctgtgaaat ttgacttaca 2520 aatccaaagc tcaaatctat ttgacaaagt aagcccagtt gtatctcaca aagttgatct 2580 tgctgtttta gctgcagttg agataagagg agtctcgagt cctgatcatg tctttcttcc 2640 gattccaaac tgggagcaca aggagaaccc tgagactgaa gaagatgttg ggccagttgt 2700 tcagcacatc tatgagctga gaaacaatgg tccaagttca ttcagcaagg caatgctcca 2760 tcttcagtgg ccttacaaat ataataataa cactctgttg tatatccttc attatgatat 2820 tgatggacca atgaactgca cttcagatat ggagatcaac cctttgagaa ttaagatctc 2880 atctttgcaa acaactgaaa agaatgacac ggttgccggg caaggtgagc gggaccatct 2940 catcactaag cgggatcttg ccctcagtga aggagatatt cacactttgg gttgtggagt 3000 tgctcagtgc ttgaagattg tctgccaagt tgggagatta gacagaggaa agagtgcaat 3060 cttgtacgta aagtcattac tgtggactga gacttttatg aataaagaaa atcagaatca 3120 ttcctattct ctgaagtcgt ctgcttcatt taatgtcata gagtttcctt ataagaatct 3180 tccaattgag gatatcacca actccacatt ggttaccact aatgtcacct ggggcattca 3240 gccagcgccc atgcctgtgc ctgtgtgggt gatcatttta gcagttctag caggattgtt 3300 gctactggct gttttggtat ttgtaatgta caggatgggc ttttttaaac gggtccggcc 3360 acctcaagaa gaacaagaaa gggagcagct tcaacctcat gaaaatggtg aaggaaactc 3420 agaaacttaa ctgcagtttt taagttatgc tacatcttga cccactagaa ttagcaactt 3480 tattatagat ttaaactttc ttcatgagga gtaaaaatcc aaggctttac tgctgatagt 3540 gctaattggc attaaccaca aaatgagaat tatatttgtc aaccttctcc ttataaataa 3600 gttcagacat acatttaata acatagggtg acttgtgttt ttaggtattt aaataataaa 3660 atttcaaggg atagttttta ttcaatgtat ataagacagg tagtgcctga tttactactt 3720 tatataaaat agtacctcct tcagttactg tttctgattt aatgtacgga actttatttg 3780 ttgttgttgt tgttgttgtt gttgttgttt taaagcagtc caaatttgga ccttagcaat 3840 catgtctttt gtataggtac ttaatgttaa tacatattac actacagttt acttttcaga 3900 atactaaaga ctttataact gcatgaactt ggattttttt aatcactcat atggtagaat 3960 tttataaaca catacatgat accatccaaa ttcttgcttt taataacaaa ggtacaatat 4020 tttgttttag tatgaaaatc tggtagatcc tattacactt ctgtttatat taaatccaca 4080 atattttatt acatttttaa cttgtataaa ttttaggtca aatccttcaa gccaacctat 4140 actaaaaatt agttccataa tcacaaatgg ctcttttgtg taattgttta atttcacctg 4200 aatatcataa tgcttaaagc catatggagt tggaaattat ttccaaagca tatttattcc 4260 attgttttag tctggctatt tacagtataa aaaaagcatt tttattaaaa tactgtgtag 4320 ttctttgaga tagttgctta tgcatatagt aagtattaca ttcttagagt agagcagagt 4380 ttttagttag tattaattta ttttcctcca ttcatgtact tttccttata tttccaaaac 4440 tgttactgag aatgggtcaa gatcagtgag aaatctttac agttgacagg aacctggacc 4500 ccttacccca actttatgag taatgcttgg aataaaaact cttaaggcaa ctcactgatt 4560 tacttctagc aatagcatga tgttacagga atattacctc tgtttaagca aggtaatgtg 4620 taaaatcagt ctcggctgtc agaataactt ctaaaaggta tttttataag cagttcaagt 4680 tactgaaaac cttttaaacc tttctgaagt tcgttagtat aaattacttt tctaggatta 4740 ttaataaaag ccacataggt ggcaagttgt agttttatat ggctctgtag agtggtgaac 4800 cttctagagg aatatatgat ttattcacag ttcctcaagg cctggggatg atgatcagtt 4860 atacctattt ttgtgcaatt acatcatgtt gtacattaga aatggagagt ttaatagctc 4920 tttaactgct gtcctcatta ggtaatgata aatatttccc ttaaataatt gactattttg 4980 ctgtgtttta aaaatgattg aaatttatct tgccatatct cataatttca tgcacaagtt 5040 gactgagcta atcttgagaa tatattcgta aaataggagc acatttagtt gaggtataca 5100 aggtaggact ctagacaaaa ccttctattt tagctttagt gaatttcaaa agtaatgggt 5160 cttggagtat agatttttat tagtagcttg aaagagctta atcatatgca gtaagtattt 5220 ttattaccaa taaatttaaa attttttaag aaaaatattt ttatcctagg gccaagtgtt 5280 gcctgccacc aatcagtaag ttagtctata acaaatttta ccctaacagt tttaccacct 5340 agtaacagtc atttctgaaa atatgttgga tagaaagtca ctctttggca aaagtgttag 5400 aatttgcttt tgtgccatct attcctttta tggcatctat cttgaaagta atcttgtatt 5460 ggagattgaa agatgctgta atttagaaat taacatgata tcttaaatta cctttatgaa 5520 atatagtttt gtataatagc atagattttc cttcaaaaaa tgaacattta tatatctaca 5580 aaaatatgga gaagagtaat ttgaaagcct actttctgaa gaaaatggtg ggattttttt 5640 ttatcatgat taaatatcaa aaaattgccc tatgaaaact ttaaatctct aaaacatttg 5700 aaatactacc atatttgtga tttattgaga ataaaaatcc attttgaaat gtaaaatttt 5760 tatgatctga ttcagtttta agaaaacatg aatgaactag aagatattaa aaacatttga 5820 cattggtaag aaatattgat actgatattg atttttatat aggtatttat ttcagaattg 5880 atattttgag aaaaatacat gtgagtcatt ttttctgttt ctcttttctc ttaacgatta 5940 tcactgtaat tctgaatctg aaaggtaaaa caattagtca aaatattatt gccatcattc 6000 tacctgtgtt atgaaactac ttattcatag ttaattctca ttaacactta catttccata 6060 aagaaaactc aagtattaat aaaagagact ttactggctt aagagggctg tgaaagattt 6120 ttgatagtga atcatgaccc taagggagag atttgtgtga taaaagtatt gtatataata 6180 gatcagcgat ttttgtaagg caaacagaat ttgtaagttg gcagatcttc ctaagttgca 6240 aaatgtaatg atgagcttgg tggagaagaa tgagtcgttc ttggaatacc tatgtgcagc 6300 cactacccat ctcaatgtca ccttgtttgc attcttggat agcttgtata tgtagtagtt 6360 tgatgaataa tttaaagaaa aacacctaaa atttgaaaaa tgattgtagg atcaaaaaag 6420 gcagatgaaa ttacttaata ctcagtgttt tggagagtat tccttttagt ttgttggttg 6480 gctggtttga acgatagaaa tatgcagcat gcaatatatg cttatatttc attttaattt 6540 ctgatatata atgaacttct tgggagaggt actgaatctt tgatgttttt tgtcattgtt 6600 ctcaagtgca atataacaat gtaaccaaat ctagataatt tcaaagttgt cattaattta 6660 gtaagcctaa tataaacaaa tatttgtatt atttttgtta gcaggaaaga gtgattaagt 6720 gaggttattt acccctaaat ggtccattct gcattgtatt tcaggctgga aatgaattat 6780 tctttaccag ttttgaaaca ctttgaaata tcctaaggta acttggaagc tgtgtagtat 6840 atcaaattaa tttgctacct aataacatag aaagtaaata tctttgtggt cacccacatt 6900 gggtgagaca gaaaatgaat ctgttctaaa atttgtaatt tgctaacttg atttgagtta 6960 gtgaaaactg gtacagtgtt ctgcttgatt tacaacatgt aacttgtgac tgtacaataa 7020 acataagcat atggtacca 7039 <210> 234 <211> 3739 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3739) <223> ITGB1 mRNA <400> 234 atgaatttac aaccaatttt ctggattgga ctgatcagtt cagtttgctg tgtgtttgct 60 caaacagatg aaaatagatg tttaaaagca aatgccaaat catgtggaga atgtatacaa 120 gcagggccaa attgtgggtg gtgcacaaat tcaacatttt tacaggaagg aatgcctact 180 tctgcacgat gtgatgattt agaagcctta aaaaagaagg gttgccctcc agatgacata 240 gaaaatccca gaggctccaa agatataaag aaaaataaaa atgtaaccaa ccgtagcaaa 300 ggaacagcag agaagctcaa gccagaggat attactcaga tccaaccaca gcagttggtt 360 ttgcgattaa gatcagggga gccacagaca tttacattaa aattcaagag agctgaagac 420 tatcccattg acctctacta ccttatggac ctgtcttact caatgaaaga cgatttggag 480 aatgtaaaaa gtcttggaac agatctgatg aatgaaatga ggaggattac ttcggacttc 540 agaattggat ttggctcatt tgtggaaaag actgtgatgc cttacattag cacaacacca 600 gctaagctca ggaacccttg cacaagtgaa cagaactgca ccagcccatt tagctacaaa 660 aatgtgctca gtcttactaa taaaggagaa gtatttaatg aacttgttgg aaaacagcgc 720 atatctggaa atttggattc tccagaaggt ggtttcgatg ccatcatgca agttgcagtt 780 tgtggatcac tgattggctg gaggaatgtt acacggctgc tggtgttttc cacagatgcc 840 gggtttcact ttgctggaga tgggaaactt ggtggcattg ttttaccaaa tgatggacaa 900 tgtcacctgg aaaataatat gtacacaatg agccattatt atgattatcc ttctattgct 960 caccttgtcc agaaactgag tgaaaataat attcagacaa tttttgcagt tactgaagaa 1020 tttcagcctg tttacaagga gctgaaaaac ttgatcccta agtcagcagt aggaacatta 1080 tctgcaaatt ctagcaatgt aattcagttg atcattgatg catacaattc cctttcctca 1140 gaagtcattt tggaaaacgg caaattgtca gaaggcgtaa caataagtta caaatcttac 1200 tgcaagaacg gggtgaatgg aacaggggaa aatggaagaa aatgttccaa tatttccatt 1260 ggagatgagg ttcaatttga aattagcata acttcaaata agtgtccaaa aaaggattct 1320 gacagcttta aaattaggcc tctgggcttt acggaggaag tagaggttat tcttcagtac 1380 atctgtgaat gtgaatgcca aagcgaaggc atccctgaaa gtcccaagtg tcatgaagga 1440 aatgggacat ttgagtgtgg cgcgtgcagg tgcaatgaag ggcgtgttgg tagacattgt 1500 gaatgcagca cagatgaagt taacagtgaa gacatggatg cttactgcag gaaagaaaac 1560 agttcagaaa tctgcagtaa caatggagag tgcgtctgcg gacagtgtgt ttgtaggaag 1620 agggataata caaatgaaat ttattctggc aaattctgcg agtgtgataa tttcaactgt 1680 gatagatcca atggcttaat ttgtggagga aatggtgttt gcaagtgtcg tgtgtgtgag 1740 tgcaacccca actacactgg cagtgcatgt gactgttctt tggatactag tacttgtgaa 1800 gccagcaacg gacagatctg caatggccgg ggcatctgcg agtgtggtgt ctgtaagtgt 1860 acagatccga agtttcaagg gcaaacgtgt gagatgtgtc agacctgcct tggtgtctgt 1920 gctgagcata aagaatgtgt tcagtgcaga gccttcaata aaggagaaaa gaaagacaca 1980 tgcacacagg aatgttccta ttttaacatt accaaggtag aaagtcggga caaattaccc 2040 cagccggtcc aacctgatcc tgtgtcccat tgtaaggaga aggatgttga cgactgttgg 2100 ttctatttta cgtattcagt gaatgggaac aacgaggtca tggttcatgt tgtggagaat 2160 ccagagtgtc ccactggtcc agacatcatt ccaattgtag ctggtgtggt tgctggaatt 2220 gttcttattg gccttgcatt actgctgata tggaagcttt taatgataat tcatgacaga 2280 agggagtttg ctaaatttga aaaggagaaa atgaatgcca aatgggacac gcaagaaaat 2340 ccgatttaca agagtcctat taataatttc aagaatccaa actacggacg taaagctggt 2400 ctctaaattg ccggtgaaaa tcctatttat aagagtgccg taacaactgt ggtcaatccg 2460 aagtatgagg gaaaatgagt actgcccgtg caaatcccac aacactgaat gcaaagtagc 2520 aatttccata gtcacagtta ggtagcttta gggcaatatt gccatggttt tactcatgtg 2580 caggttttga aaatgtacaa tatgtataat ttttaaaatg ttttattatt ttgaaaataa 2640 tgttgtaatt catgccaggg actgacaaaa gacttgagac aggatggtta ctcttgtcag 2700 ctaaggtcac attgtgcctt tttgaccttt tcttcctgga ctattgaaat caagcttatt 2760 ggattaagtg atatttctat agcgattgaa agggcaatag ttaaagtaat gagcatgatg 2820 agagtttctg ttaatcatgt attaaaactg atttttagct ttacaaatat gtcagtttgc 2880 agttatgcag aatccaaagt aaatgtcctg ctagctagtt aaggattgtt ttaaatctgt 2940 tattttgcta tttgcctgtt agacatgact gatgacatat ctgaaagaca agtatgttga 3000 gagttgctgg tgtaaaatac gtttgaaata gttgatctac aaaggccatg ggaaaaattc 3060 agagagttag gaaggaaaaa ccaatagctt taaaacctgt gtgccatttt aagagttact 3120 taatgtttgg taacttttat gccttcactt tacaaattca agccttagat aaaagaaccg 3180 agcaattttc tgctaaaaag tccttgattt agcactattt acatacaggc catactttac 3240 aaagtatttg ctgaatgggg accttttgag ttgaatttat tttattattt ttattttgtt 3300 taatgtctgg tgctttctgt cacctcttct aatcttttaa tgtatttgtt tgcaattttg 3360 gggtaagact ttttttatga gtactttttc tttgaagttt tagcggtcaa tttgcctttt 3420 taatgaacat gtgaagttat actgtggcta tgcaacagct ctcacctacg cgagtcttac 3480 tttgagttag tgccataaca gaccactgta tgtttacttc tcaccatttg agttgcccat 3540 cttgtttcac actagtcaca ttcttgtttt aagtgccttt agttttaaca gttcactttt 3600 tacagtgcta tttactgaag ttatttatta aatatgccta aaatacttaa atcggatgtc 3660 ttgactctga tgtattttat caggttgtgt gcatgaaatt tttatagatt aaagaagttg 3720 aggaaaagca aaaaaaaaa 3739 <210> 235 <211> 4894 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4894) <223> ITGB3 mRNA <400> 235 cgccgcggga ggcggacgag atgcgagcgc ggccgcggcc ccggccgctc tgggcgactg 60 tgctggcgct gggggcgctg gcgggcgttg gcgtaggagg gcccaacatc tgtaccacgc 120 gaggtgtgag ctcctgccag cagtgcctgg ctgtgagccc catgtgtgcc tggtgctctg 180 atgaggccct gcctctgggc tcacctcgct gtgacctgaa ggagaatctg ctgaaggata 240 actgtgcccc agaatccatc gagttcccag tgagtgaggc ccgagtacta gaggacaggc 300 ccctcagcga caagggctct ggagacagct cccaggtcac tcaagtcagt ccccagagga 360 ttgcactccg gctccggcca gatgattcga agaatttctc catccaagtg cggcaggtgg 420 aggattaccc tgtggacatc tactacttga tggacctgtc ttactccatg aaggatgatc 480 tgtggagcat ccagaacctg ggtaccaagc tggccaccca gatgcgaaag ctcaccagta 540 acctgcggat tggcttcggg gcatttgtgg acaagcctgt gtcaccatac atgtatatct 600 ccccaccaga ggccctcgaa aacccctgct atgatatgaa gaccacctgc ttgcccatgt 660 ttggctacaa acacgtgctg acgctaactg accaggtgac ccgcttcaat gaggaagtga 720 agaagcagag tgtgtcacgg aaccgagatg ccccagaggg tggctttgat gccatcatgc 780 aggctacagt ctgtgatgaa aagattggct ggaggaatga tgcatcccac ttgctggtgt 840 ttaccactga tgccaagact catatagcat tggacggaag gctggcaggc attgtccagc 900 ctaatgacgg gcagtgtcat gttggtagtg acaatcatta ctctgcctcc actaccatgg 960 attatccctc tttggggctg atgactgaga agctatccca gaaaaacatc aatttgatct 1020 ttgcagtgac tgaaaatgta gtcaatctct atcagaacta tagtgagctc atcccaggga 1080 ccacagttgg ggttctgtcc atggattcca gcaatgtcct ccagctcatt gttgatgctt 1140 atgggaaaat ccgttctaaa gtagagctgg aagtgcgtga cctccctgaa gagttgtctc 1200 tatccttcaa tgccacctgc ctcaacaatg aggtcatccc tggcctcaag tcttgtatgg 1260 gactcaagat tggagacacg gtgagcttca gcattgaggc caaggtgcga ggctgtcccc 1320 aggagaagga gaagtccttt accataaagc ccgtgggctt caaggacagc ctgatcgtcc 1380 aggtcacctt tgattgtgac tgtgcctgcc aggcccaagc tgaacctaat agccatcgct 1440 gcaacaatgg caatgggacc tttgagtgtg gggtatgccg ttgtgggcct ggctggctgg 1500 gatcccagtg tgagtgctca gaggaggact atcgcccttc ccagcaggac gaatgcagcc 1560 cccgggaggg tcagcccgtc tgcagccagc ggggcgagtg cctctgtggt caatgtgtct 1620 gccacagcag tgactttggc aagatcacgg gcaagtactg cgagtgtgac gacttctcct 1680 gtgtccgcta caagggggag atgtgctcag gccatggcca gtgcagctgt ggggactgcc 1740 tgtgtgactc cgactggacc ggctactact gcaactgtac cacgcgtact gacacctgca 1800 tgtccagcaa tgggctgctg tgcagcggcc gcggcaagtg tgaatgtggc agctgtgtct 1860 gtatccagcc gggctcctat ggggacacct gtgagaagtg ccccacctgc ccagatgcct 1920 gcacctttaa gaaagaatgt gtggagtgta agaagtttga ccggggagcc ctacatgacg 1980 aaaatacctg caaccgttac tgccgtgacg agattgagtc agtgaaagag cttaaggaca 2040 ctggcaagga tgcagtgaat tgtacctata agaatgagga tgactgtgtc gtcagattcc 2100 agtactatga agattctagt ggaaagtcca tcctgtatgt ggtagaagag ccagagtgtc 2160 ccaagggccc tgacatcctg gtggtcctgc tctcagtgat gggggccatt ctgctcattg 2220 gccttgccgc cctgctcatc tggaaactcc tcatcaccat ccacgaccga aaagaattcg 2280 ctaaatttga ggaagaacgc gccagagcaa aatgggacac agccaacaac ccactgtata 2340 aagaggccac gtctaccttc accaatatca cgtaccgggg cacttaatga taagcagtca 2400 tcctcagatc attatcagcc tgtgccacga ttgcaggagt ccctgccatc atgtttacag 2460 aggacagtat ttgtggggag ggatttgggg ctcagagtgg ggtaggttgg gagaatgtca 2520 gtatgtggaa gtgtgggtct gtgtgtgtgt atgtgggggt ctgtgtgttt atgtgtgtgt 2580 gttgtgtgtg ggagtgtgta atttaaaatt gtgatgtgtc ctgataagct gagctcctta 2640 gcctttgtcc cagaatgcct cctgcaggga ttcttcctgc ttagcttgag ggtgactatg 2700 gagctgagca ggtgttcttc attacctcag tgagaagcca gctttcctca tcaggccatt 2760 gtccctgaag agaagggcag ggctgaggcc tctcattcca gaggaaggga caccaagcct 2820 tggctctacc ctgagttcat aaatttatgg ttctcaggcc tgactctcag cagctatggt 2880 aggaactgct gggcttggca gcccgggtca tctgtacctc tgcctccttt cccctccctc 2940 aggccgaagg aggagtcagg gagagctgaa ctattagagc tgcctgtgcc ttttgccatc 3000 ccctcaaccc agctatggtt ctctcgcaag ggaagtcctt gcaagctaat tctttgacct 3060 gttgggagtg aggatgtctg ggccactcag gggtcattca tggcctgggg gatgtaccag 3120 catctcccag ttcataatca caacccttca gatttgcctt attggcagct ctactctgga 3180 ggtttgttta gaagaagtgt gtcaccctta ggccagcacc atctctttac ctcctaattc 3240 cacaccctca ctgctgtaga catttgctat gagctgggga tgtctctcat gaccaaatgc 3300 ttttcctcaa agggagagag tgctattgta gagccagagg tctggcccta tgcttccggc 3360 ctcctgtccc tcatccatag cacctccaca tacctggccc tgtgccttgg tgtgctgtat 3420 ccatccatgg ggctgattgt atttaccttc tacctcttgg ctgccttgtg aaggaattat 3480 tcccatgagt tggctgggaa taagtgccag gatggaatga tgggtcagtt gtatcagcac 3540 gtgtggcctg ttcttctatg ggttggacaa cctcatttta actcagtctt taatctgaga 3600 ggccacagtg caattttatt ttatttttct catgatgagg ttttcttaac ttaaaagaac 3660 atgtatataa acatgcttgc attatatttg taaatttatg tgatggcaaa gaaggagagc 3720 ataggaaacc acacagactt gggcagggta cagacactcc cacttggcat cattcacagc 3780 aagtcactgg ccagtggctg gatctgtgag gggctctctc atgatagaag gctatgggga 3840 tagatgtgtg gacacattgg acctttcctg aggaagaggg actgttcttt tgtcccagaa 3900 aagcagtggc tccattggtg ttgacataca tccaacatta aaagccaccc ccaaatgccc 3960 aagaaaaaaa gaaagactta tcaacatttg ttccatgagc agaaaactgg agctctggcc 4020 tcagtgttac agctaaataa tctttaatta aggcaagtca ctttcttctt cttaaagctg 4080 ttttctagtt tgagaaatga tgggatttta gcagccagtc ttgaaggtct ctttcagtat 4140 caacattcta agatgctggg acttactgtg tcatcaaatg tgcggttaag attctctggg 4200 atattgatac tgtttgtgtt tttagttggg agatctgaga gacctggctt tggcaagagc 4260 agatgtcatt ccatatcacc tttctcaatg aaagtctcat tctatcctct ctccaaaccc 4320 gttttccaac atttgttaat agttacgtct ctcctgatgt agcacttaag cttcatttag 4380 ttattatttc tttcttcact ttgcacacat ttgcatccac atattaggga agaggaatcc 4440 ataagtagct gaaatatcta ttctgtatta ttgtgttaac attgagaata agccttggaa 4500 ttagatatgg ggcaatgact gagccctgtc tcacccatgg attactcctt actgtaggga 4560 atggcagtat ggtagaggga taaatagggg gcggggaggg atagtcatgg atccaagaag 4620 tccttagaaa tagtggcagg gaacaggtgt ggaagctcat gcctgtaatt ataaccttca 4680 gctactaaga caggtgtggt ggctcacgcc tgtgattata atcttcagtt actaagacag 4740 agtccatgag agtgttaatg ggacattttc tttagataag atgttttata tgaagaaact 4800 gtatcaaagg gggaagaaaa tgtatttaac aggtgaatca aatcaggaat cttgtctgag 4860 ctactggaat gaagttcaca ggtcttgaag acca 4894 <210> 236 <211> 4392 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4392) <223> ITGB5 mRNA <400> 236 gccgccgagc ggagccagcc cctcccctac ccggagcagc ccgctggggc cgtcccgagc 60 ggcgacacac taggagtccc ggccggccag ccagggcagc cgcggtcccg ggactcggcc 120 gtgagtgctg cgggacggat ggtggcggcg gggcgcgggc cagcgcgggc gccgtgagcc 180 ggagctgcgc gcggggcatg cggctgcggc ccccggccct cggcccccgc gctccggccc 240 cagccccggc cgccggcccc cgcggagtgc agcgaccgcg ccgccgctga gggaggcgcc 300 ccaccatgcc gcgggccccg gcgccgctgt acgcctgcct cctggggctc tgcgcgctcc 360 tgccccggct cgcaggtctc aacatatgca ctagtggaag tgccacctca tgtgaagaat 420 gtctgctaat ccacccaaaa tgtgcctggt gctccaaaga ggacttcgga agcccacggt 480 ccatcacctc tcggtgtgat ctgagggcaa accttgtcaa aaatggctgt ggaggtgaga 540 tagagagccc agccagcagc ttccatgtcc tgaggagcct gcccctcagc agcaagggtt 600 cgggctctgc aggctgggac gtcattcaga tgacaccaca ggagattgcc gtgaacctcc 660 ggcccggtga caagaccacc ttccagctac aggttcgcca ggtggaggac tatcctgtgg 720 acctgtacta cctgatggac ctctccctgt ccatgaagga tgacttggac aatatccgga 780 gcctgggcac caaactcgcg gaggagatga ggaagctcac cagcaacttc cggttgggat 840 ttgggtcttt tgttgataag gacatctctc ctttctccta cacggcaccg aggtaccaga 900 ccaatccgtg cattggttac aagttgtttc caaattgcgt cccctccttt gggttccgcc 960 atctgctgcc tctcacagac agagtggaca gcttcaatga ggaagttcgg aaacagaggg 1020 tgtcccggaa ccgagatgcc cctgaggggg gctttgatgc agtactccag gcagccgtct 1080 gcaaggagaa gattggctgg cgaaaggatg cactgcattt gctggtgttc acaacagatg 1140 atgtgcccca catcgcattg gatggaaaat tgggaggcct ggtgcagcca cacgatggcc 1200 agtgccacct gaacgaggcc aacgagtaca ctgcatccaa ccagatggac tatccatccc 1260 ttgccttgct tggagagaaa ttggcagaga acaacatcaa cctcatcttt gcagtgacaa 1320 aaaaccatta tatgctgtac aagaatttta cagccctgat acctggaaca acggtggaga 1380 ttttagatgg agactccaaa aatattattc aactgattat taatgcatac aatagtatcc 1440 ggtctaaagt ggagttgtca gtctgggatc agcctgagga tcttaatctc ttctttactg 1500 ctacctgcca agatggggta tcctatcctg gtcagaggaa gtgtgagggt ctgaagattg 1560 gggacacggc atcttttgaa gtatcattgg aggcccgaag ctgtcccagc agacacacgg 1620 agcatgtgtt tgccctgcgg ccggtgggat tccgggacag cctggaggtg ggggtcacct 1680 acaactgcac gtgcggctgc agcgtggggc tggaacccaa cagcgccagg tgcaacggga 1740 gcgggaccta tgtctgcggc ctgtgtgagt gcagccccgg ctacctgggc accaggtgcg 1800 agtgccagga tggggagaac cagagcgtgt accagaacct gtgccgggag gcagagggca 1860 agccactgtg cagcgggcgt ggggactgca gctgcaacca gtgctcctgc ttcgagagcg 1920 agtttggcaa gatctatggg cctttctgtg agtgcgacaa cttctcctgt gccaggaaca 1980 agggagtcct ctgctcaggc catggcgagt gtcactgcgg ggaatgcaag tgccatgcag 2040 gttacatcgg ggacaactgt aactgctcga cagacatcag cacatgccgg ggcagagatg 2100 gccagatctg cagcgagcgt gggcactgtc tctgtgggca gtgccaatgc acggagccgg 2160 gggcctttgg ggagatgtgt gagaagtgcc ccacctgccc ggatgcatgc agcaccaaga 2220 gagattgcgt cgagtgcctg ctgctccact ctgggaaacc tgacaaccag acctgccaca 2280 gcctatgcag ggatgaggtg atcacatggg tggacaccat cgtgaaagat gaccaggagg 2340 ctgtgctatg tttctacaaa accgccaagg actgcgtcat gatgttcacc tatgtggagc 2400 tccccagtgg gaagtccaac ctgaccgtcc tcagggagcc agagtgtgga aacaccccca 2460 acgccatgac catcctcctg gctgtggtcg gtagcatcct ccttgttggg cttgcactcc 2520 tggctatctg gaagctgctt gtcaccatcc acgaccggag ggagtttgca aagtttcaga 2580 gcgagcgatc cagggcccgc tatgaaatgg cttcaaatcc attatacaga aagcctatct 2640 ccacgcacac tgtggacttc accttcaaca agttcaacaa atcctacaat ggcactgtgg 2700 actgatgttt ccttctccga ggggctggag cggggatctg atgaaaaggt cagactgaaa 2760 cgccttgcac ggctgctcgg cttgatcaca gctccctagg taggcaccac agagaagacc 2820 ttctagtgag cctgggccag gagcccacag tgcctgtaca ggaaggtgcc tggccatgtc 2880 acctggctgc taggccagag ccatgccagg ctgcgtccct ccgagcttgg gataaagcaa 2940 ggggaccttg gcgctctcag ctttccctgc cacatccagc ttgttgtccc aatgaaatac 3000 tgagatgctg ggctgtctct cccttccagg aatgctgggc ccccagcctg gccagacaag 3060 aagactgtca ggaagggtcg gagtctgtaa aaccagcata cagtttggct tttttcacat 3120 tgatcatttt tatatgaaat aaaaagatcc tgcatttatg gtgtagttct gagtcctgag 3180 acttttctgc gtgatggcta tgccttgcac acaggtgttg gtgatggggc tgttgagatg 3240 cctgttgaag gtacatcgtt tgcaaatgtc agtttcctct cctgtccgtg tttgtttagt 3300 acttttataa tgaaaagaaa caagattgtt tgggattgga agtaaagatt aaaaccaaaa 3360 gaatttgtgt ttgtctgata ctctctgtgt gtttctttct ttctgagcgg acttaaaatg 3420 gtgcccccag tggggattga agcggccgtg tacttcctca gggatgggac acaggctggt 3480 ctgatactcc agactgcagc ttgtcaagta agcatgaggt gctcggggca gtgagggctg 3540 tgcaaggggg aacactgagc agataccttt ggccccttcc agcttttact gacagagagt 3600 tccaggctag acaccataaa aaccacccct tgttctgagg ggctgaggct ggaaatagat 3660 tgtacagaca agcaagggtt gagtggtggt tcccacacga agtcatctct taatcatcat 3720 tagcaatagc agttcccttc caaggcctcc cctcactccc gaaacactta cgtcccatgc 3780 aggcccaatg caaaaaaaca catttgagct tttttcccgc agggccatga agtcccctta 3840 agttcccata tctaagatgg ttgactgacc ctctcccctt atgtacagaa gaggaaactg 3900 attctcagag aggggaagtg gcttgcccga gtgtttgtta ggaggttact gaatgacaaa 3960 ctgttcctaa gaccccatct catgctggcc agagggccag cctcctcatt cctgcttgct 4020 cttagaaaat ctttcactga tcattttttg tcactggaat aacttcaagg ttattatgct 4080 ttcattccaa atggatctgt cctcagctct ggacccaatt ccccttactt cattttggca 4140 aacactaagt caaatagtga aatgcctgtc actacataga acctattacc tggggcaaat 4200 acgaacagat tgagtttcct tcatcttgtg taaatatgat gaaacagaga cctggtaact 4260 tggtgacact gttaaaccct ttttgggata aagccaaatg taaatgaaaa cattaaacag 4320 ataaattgtg gtgttgagac ttttctgaat tgagaaaaat aaatgtaatt ttggaagaaa 4380 aaaaaaaaaa aa 4392 <210> 237 <211> 1183 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1183) <223> KRTAP1-5 mRNA <400> 237 aaacctcaga aactcctcca agcaacctaa ctcttaaccc aacttctgac accatgacct 60 gctgccagac cagcttctgt ggatatccca gcttctccat cagtgggacc tgtggctcca 120 gctgctgcca gccaagctgc tgtgagacca gctgctgcca gccacgcagc tgccagacta 180 gcttctgcgg atttcccagc ttctcaacca gtgggacctg cagctccagt tgctgccagc 240 caagctgctg tgagaccagc tgctgccagc caagctgctg tgagaccagc tgctgccagc 300 caagctgctg ccagatcagc tcctgcggaa ctggctgtgg cattggtggt ggcatcagct 360 atggccagga gggcagcagt ggagctgtga gcacccgtat caggtggtgc cgcccagaca 420 gtcgtgtgga gggcacctac ctacccccct gctgtgtggt gagctgcacg cccccatcct 480 gctgccaact gcaccatgcc caggcctcct gctgccgccc gtcctactgt ggacagtcct 540 gctgccgccc agtctgctgc tgtgagccca cttgctgaaa gccagtttgc ttattttcaa 600 ttgcctaggt cacagtgtct ctgaactgtt catcccttga ccacctctgg accactaaca 660 agttctcaga ctttgcattg cttgtgatgg agactactaa gtatatgagc tcacaattct 720 atctgattcc attctacaat gaataccttg acccttcact ggggacacag aaatgctaca 780 aagccacctg ctgatcatca atttgcttgg gatatactat ttctgatatt tctgcaggat 840 taaaaattac tgacatgttg tggaatttat ccatgagaac tatccacaag tctaatgttt 900 ccatgcttta taatctattt tatcttgttt acctaaaatt ttttgcaaca tcaaagacac 960 caaattatag ccaagtgaca ttcctcaagt caccagagag aatggaagct catcacccaa 1020 cattcagctt ctaagaagta ggctggactt tccacatttt aacatctgat ccatcccttg 1080 gtttttggat cataatgatc ttgcctgctg gatatttcag ttatatctgt gatacaatgt 1140 cttctgtcat ttcttaataa atattatata ctaggcaaag aaa 1183 <210> 238 <211> 1965 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1965) <223> LPXN mRNA <400> 238 aggtcgcgac gcgtgccgta catccgggct caagcgtcga gccaattgct ggtctgatgg 60 gagggttttt cctacttttt cttacttttt atctgggcgt tggcgtacct ttctcggggt 120 gtctgcgtaa ctgcccagac ttgccttggt ttggtcagat gacacctcct ctgggactgg 180 ctagccagcg ttcatgtcta cattattgat ctcgtcttcc gatgccttat tggaggaact 240 ggaacgctcc acccttcagg acagtgatga atattccaac ccagctcctc ttcccctgga 300 tcagcattcc agaaaggaga ctaaccttga tgagacttcg gagatccttt ctattcagga 360 taacacaagt cccttgccgg cgcagctcgt gtatactacc aatatccagg agctcaatgt 420 ctacagtgaa gcccaagagc caaaggaatc accaccacct tctaaaacgt cagcagctgc 480 tcagttggat gagctcatgg ctcacctgac tgagatgcag gccaaggttg cagtgagagc 540 agatgctggc aagaagcact taccagacaa gcaggatcac aaggcctccc tggactcaat 600 gcttgggggt ctggagcagg aattgcagga ccttggcatt gccacagtgc ccaagggcca 660 ttgtgcatcc tgccagaaac cgattgctgg gaaggtgatc catgctctag ggcaatcatg 720 gcatcctgag cattttgtct gtactcattg caaagaagag attggctcca gtcccttctt 780 tgagcggagt ggcttggcct actgccccaa cgactaccac caactttttt ctccacgctg 840 tgcttactgc gctgctccca tcctggataa agtgctgaca gcaatgaacc agacctggca 900 cccagagcac ttcttctgct ctcactgcgg agaggtgttt ggtgcagaag gctttcatga 960 gaaggacaag aagccatatt gccgaaagga tttcttagcc atgttctcac ccaagtgtgg 1020 tggctgcaat cgcccagtgt tggaaaacta cctttcagcc atggacactg tctggcaccc 1080 agagtgcttt gtttgtgggg actgcttcac cagtttttct actggctcct tctttgaact 1140 ggatggacgt ccattctgtg agctccatta ccatcaccgc cggggaacgc tctgccatgg 1200 gtgtgggcag cccatcactg gccgttgtat cagtgccatg gggtacaagt tccatcctga 1260 gcactttgtg tgtgctttct gcctgacaca gttgtcgaag ggcattttca gggagcagaa 1320 tgacaagacc tattgtcaac cttgcttcaa taagctcttc ccactgtaat gccaactgat 1380 ccatagcctc ttcagattcc ttataaaatt taaaccaaga gaggagagga aagggtaaat 1440 tttctgttac tgaccttctg cttaatagtc ttatagaaaa aggaaaggtg atgagcaaat 1500 aaaggaactt ctagacttta catgactagg ctgataatct tattttttag gcttctatac 1560 agttaattct ataaattctc tttctccctc tcttctccaa tcaagcactt ggagttagat 1620 ctaggtcctt ctatctcgtc cctctacaga tgtattttcc acttgcataa ttcatgccaa 1680 cactggtttt cttaggtttc tccattttca cctctagtga tggccctact catatcttct 1740 ctaatttggt cctgatactt gtttcttttc acgttttccc atttccctgt ggctcactgt 1800 cttacaatca ctgctgtgga atcatgatac cacttttagc tctttgcatc ttccttcagt 1860 gtatttttgt ttttcaagag gaagtagatt ttaactggac aactttgagt actgacatca 1920 ttgataaata aactggcttg tggtttcaat aaaaaaaaaa aaaaa 1965 <210> 239 <211> 1514 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1514) <223> MAPK1 mRNA <400> 239 gcccctccct ccgcccgccc gccggcccgc ccgtcagtct ggcaggcagg caggcaatcg 60 gtccgagtgg ctgtcggctc ttcagctctc ccgctcggcg tcttccttcc tcctcccggt 120 cagcgtcggc ggctgcaccg gcggcggcgc agtccctgcg ggaggggcga caagagctga 180 gcggcggccg ccgagcgtcg agctcagcgc ggcggaggcg gcggcggccc ggcagccaac 240 atggcggcgg cggcggcggc gggcgcgggc ccggagatgg tccgcgggca ggtgttcgac 300 gtggggccgc gctacaccaa cctctcgtac atcggcgagg gcgcctacgg catggtgtgc 360 tctgcttatg ataatgtcaa caaagttcga gtagctatca agaaaatcag cccctttgag 420 caccagacct actgccagag aaccctgagg gagataaaaa tcttactgcg cttcagacat 480 gagaacatca ttggaatcaa tgacattatt cgagcaccaa ccatcgagca aatgaaagat 540 gtatatatag tacaggacct catggaaaca gatctttaca agctcttgaa gacacaacac 600 ctcagcaatg accatatctg ctattttctc taccagatcc tcagagggtt aaaatatatc 660 cattcagcta acgttctgca ccgtgacctc aagccttcca acctgctgct caacaccacc 720 tgtgatctca agatctgtga ctttggcctg gcccgtgttg cagatccaga ccatgatcac 780 acagggttcc tgacagaata tgtggccaca cgttggtaca gggctccaga aattatgttg 840 aattccaagg gctacaccaa gtccattgat atttggtctg taggctgcat tctggcagaa 900 atgctttcta acaggcccat ctttccaggg aagcattatc ttgaccagct gaaccacatt 960 ttgggtattc ttggatcccc atcacaagaa gacctgaatt gtataataaa tttaaaagct 1020 aggaactatt tgctttctct tccacacaaa aataaggtgc catggaacag gctgttccca 1080 aatgctgact ccaaagctct ggacttattg gacaaaatgt tgacattcaa cccacacaag 1140 aggattgaag tagaacaggc tctggcccac ccatatctgg agcagtatta cgacccgagt 1200 gacgagccca tcgccgaagc accattcaag ttcgacatgg aattggatga cttgcctaag 1260 gaaaagctca aagaactaat ttttgaagag actgctagat tccagccagg atacagatct 1320 taaatttgtc aggtacctgg agtttaatac agtgagctct agcaagggag gcgctgcctt 1380 ttgtttctag aatattatgt tcctcaaggt ccattatttt gtattctttt ccaagctcct 1440 tattggaagg tattttttta aatttagaat taaaaattat ttagaaagtt acatataaaa 1500 aaaaaaaaaa aaaa 1514 <210> 240 <211> 1174 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1174) <223> MAPK3 mRNA <400> 240 ctggcgcgcg cggccctgcg ggtgacaggc aggcgggaag gggcggggcc tcgggcgggg 60 ccgccgtggg gaggagggcg gtgggagggg aggagtggag atggcggcgg cggcggctca 120 ggggggcggg ggcggggagc cccgtagaac cgagggggtc ggcccggggg tcccggggga 180 ggtggagatg gtgaaggggc agccgttcga cgtgggcccg cgctacacgc agttgcagta 240 catcggcgag ggcgcgtacg gcatggtcag ctcggcctat gaccacgtgc gcaagactcg 300 cgtggccatc aagaagatca gccccttcga acatcagacc tactgccagc gcacgctccg 360 ggagatccag atcctgctgc gcttccgcca tgagaatgtc atcggcatcc gagacattct 420 gcgggcgtcc accctggaag ccatgagaga tgtctacatt gtgcaggacc tgatggagac 480 tgacctgtac aagttgctga aaagccagca gctgagcaat gaccatatct gctacttcct 540 ctaccagatc ctgcggggcc tcaagtacat ccactccgcc aacgtgctcc accgagatct 600 aaagccctcc aacctgctca tcaacaccac ctgcgacctt aagatttgtg atttcggcct 660 ggcccggatt gccgatcctg agcatgacca caccggcttc ctgacggagt atgtggctac 720 gcgctggtac cgggccccag agatcatgct gaactccaag ggctatacca agtccatcga 780 catctggtct gtgggctgca ttctggctga gatgctctct aaccggccca tcttccctgg 840 caagcactac ctggatcagc tcaaccacat tctgggcatc ctgggctccc catcccagga 900 ggacctgaat tgtatcatca acatgaaggc ccgaaactac ctacagtctc tgccctccaa 960 gaccaaggtg gcttgggcca agcttttccc caagtcagac tccaaagccc ttgacctgct 1020 ggaccggatg ttaaccttta accccaataa acggatcaca gtggaggaag cgctggctca 1080 cccctacctg gagcagtact atgacccgac ggatgaggtg ggccagtccc cagcagcagt 1140 ggggctgggg gcaggggagc aggggggcac gtag 1174 <210> 241 <211> 3950 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3950) <223> MCL1 mRNA <400> 241 acttctcact tccgcttcct tccagtaagg agtcggggtc ttccccagtt ttctcagcca 60 ggcggcggcg gcgactggca atgtttggcc tcaaaagaaa cgcggtaatc ggactcaacc 120 tctactgtgg gggggccggc ttgggggccg gcagcggcgg cgccacccgc ccgggagggc 180 gacttttggc tacggagaag gaggcctcgg cccggcgaga gataggggga ggggaggccg 240 gcgcggtgat tggcggaagc gccggcgcaa gccccccgtc caccctcacg ccagactccc 300 ggagggtcgc gcggccgccg cccattggcg ccgaggtccc cgacgtcacc gcgacccccg 360 cgaggctgct tttcttcgcg cccacccgcc gcgcggcgcc gcttgaggag atggaagccc 420 cggccgctga cgccatcatg tcgcccgaag aggagctgga cgggtacgag ccggagcctc 480 tcgggaagcg gccggctgtc ctgccgctgc tggagttggt cggggaatct ggtaataaca 540 ccagtacgga cgggtcacta ccctcgacgc cgccgccagc agaggaggag gaggacgagt 600 tgtaccggca gtcgctggag attatctctc ggtaccttcg ggagcaggcc accggcgcca 660 aggacacaaa gccaatgggc aggtctgggg ccaccagcag gaaggcgctg gagaccttac 720 gacgggttgg ggatggcgtg cagcgcaacc acgagacggc cttccaaggc atgcttcgga 780 aactggacat caaaaacgaa gacgatgtga aatcgttgtc tcgagtgatg atccatgttt 840 tcagcgacgg cgtaacaaac tggggcagga ttgtgactct catttctttt ggtgcctttg 900 tggctaaaca cttgaagacc ataaaccaag aaagctgcat cgaaccatta gcagaaagta 960 tcacagacgt tctcgtaagg acaaaacggg actggctagt taaacaaaga ggctgggatg 1020 ggtttgtgga gttcttccat gtagaggacc tagaaggtgg catcaggaat gtgctgctgg 1080 cttttgcagg tgttgctgga gtaggagctg gtttggcata tctaataaga tagccttact 1140 gtaagtgcaa tagttgactt ttaaccaacc accaccacca ccaaaaccag tttatgcagt 1200 tggactccaa gctgtaactt cctagagttg caccctagca acctagccag aaaagcaagt 1260 ggcaagagga ttatggctaa caagaataaa tacatgggaa gagtgctccc cattgattga 1320 agagtcactg tctgaaagaa gcaaagttca gtttcagcaa caaacaaact ttgtttggga 1380 agctatggag gaggactttt agatttagtg aagatggtag ggtggaaaga cttaatttcc 1440 ttgttgagaa caggaaagtg gccagtagcc aggcaagtca tagaattgat tacccgccga 1500 attcattaat ttactgtagt gttaagagaa gcactaagaa tgccagtgac ctgtgtaaaa 1560 gttacaagta atagaactat gactgtaagc ctcagtactg tacaagggaa gcttttcctc 1620 tctctaatta gctttcccag tatacttctt agaaagtcca agtgttcagg acttttatac 1680 ctgttatact ttggcttggt ttccatgatt cttactttat tagcctagtt tatcaccaat 1740 aatacttgac ggaaggctca gtaattagtt atgaatatgg atatcctcaa ttcttaagac 1800 agcttgtaaa tgtatttgta aaaattgtat atatttttac agaaagtcta tttctttgaa 1860 acgaaggaag tatcgaattt acattagttt ttttcatacc cttttgaact ttgcaacttc 1920 cgtaattagg aacctgtttc ttacagcttt tctatgctaa actttgttct gttcagttct 1980 agagtgtata cagaacgaat tgatgtgtaa ctgtatgcag actggttgta gtggaacaaa 2040 tctgataact atgcaggttt aaattttctt atctgatttt ggtaagtatt ccttaggttt 2100 ttctttgaaa acctgggatt gagaggttga tgaatggaaa ttctttcact tcattatatg 2160 caagttttca ataattaggt ctaagtggag ttttaaggtt actgatgact tacaaataat 2220 gggctctgat tgggcaatac tcatttgagt tccttccatt tgacctaatt taactggtga 2280 aatttaaagt gaattcatgg gctcatcttt aaagctttta ctaaaagatt ttcagctgaa 2340 tggaactcat tagctgtgtg catataaaaa gatcacatca ggtggatgga gagacatttg 2400 atcccttgtt tgcttaataa attataaaat gatggcttgg aaaagcaggc tagtctaacc 2460 atggtgctat tattaggctt gcttgttaca cacacaggtc taagcctagt atgtcaataa 2520 agcaaatact tactgttttg tttctattaa tgattcccaa accttgttgc aagtttttgc 2580 attggcatct ttggatttca gtcttgatgt ttgttctatc agacttaacc ttttatttcc 2640 tgtccttcct tgaaattgct gattgttctg ctccctctac agatatttat atcaattcct 2700 acagctttcc cctgccatcc ctgaactctt tctagccctt ttagattttg gcactgtgaa 2760 acccctgctg gaaacctgag tgaccctccc tccccaccaa gagtccacag acctttcatc 2820 tttcacgaac ttgatcctgt tagcaggtgg taataccatg ggtgctgtga cactaacagt 2880 cattgagagg tgggaggaag tcccttttcc ttggactggt atcttttcaa ctattgtttt 2940 atcctgtctt tgggggcaat gtgtcaaaag tcccctcagg aattttcaga ggaaagaaca 3000 ttttatgagg ctttctctaa agtttccttt gtataggagt atgctcactt aaatttacag 3060 aaagaggtga gctgtgttaa acctcagagt ttaaaagcta ctgataaact gaagaaagtg 3120 tctatattgg aactagggtc atttgaaagc ttcagtctcg gaacatgacc tttagtctgt 3180 ggactccatt taaaaatagg tatgaataag atgactaaga atgtaatggg gaagaactgc 3240 cctgcctgcc catctcagag ccataaggtc atctttgcta gagctatttt tacctatgta 3300 tttatcgttc ttgatcataa gccgcttatt tatatcatgt atctctaagg acctaaaagc 3360 actttatgta gtttttaatt aatcttaaga tctggttacg gtaactaaaa aagcctgtct 3420 gccaaatcca gtggaaacaa gtgcatagat gtgaattggt ttttaggggc cccacttccc 3480 aattcattag gtatgactgt ggaaatacag acaaggatct tagttgatat tttgggcttg 3540 gggcagtgag ggcttaggac accccaagtg gtttgggaaa ggaggagggg agtggtgggt 3600 ttataggggg aggaggaggc aggtggtcta agtgctgact ggctacgtag ttcgggcaaa 3660 tcctccaaaa gggaaaggga ggatttgctt agaaggatgg cgctcccagt gactactttt 3720 tgacttctgt ttgtcttacg cttctctcag ggaaaaacat gcagtcctct agtgtttcat 3780 gtacattctg tggggggtga acaccttggt tctggttaaa cagctgtact tttgatagct 3840 gtgccaggaa gggttaggac caactacaaa ttaatgttgg ttgtcaaatg tagtgtgttt 3900 ccctaacttt ctgtttttcc tgagaaaaaa aaataaatct tttattcaaa 3950 <210> 242 <211> 561 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(561) <223> MIF mRNA <400> 242 accacagtgg tgtccgagaa gtcaggcacg tagctcagcg gcggccgcgg cgcgtgcgtc 60 tgtgcctctg cgcgggtctc ctggtccttc tgccatcatg ccgatgttca tcgtaaacac 120 caacgtgccc cgcgcctccg tgccggacgg gttcctctcc gagctcaccc agcagctggc 180 gcaggccacc ggcaagcccc cccagtacat cgcggtgcac gtggtcccgg accagctcat 240 ggccttcggc ggctccagcg agccgtgcgc gctctgcagc ctgcacagca tcggcaagat 300 cggcggcgcg cagaaccgct cctacagcaa gctgctgtgc ggcctgctgg ccgagcgcct 360 gcgcatcagc ccggacaggg tctacatcaa ctattacgac atgaacgcgg ccaatgtggg 420 ctggaacaac tccaccttcg cctaagagcc gcagggaccc acgctgtctg cgctggctcc 480 acccgggaac ccgccgcacg ctgtgttcta ggcccgccca ccccaacctt ctggtgggga 540 gaaataaacg gtttagagac t 561 <210> 243 <211> 1971 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1971) <223> MMP1 mRNA <400> 243 atattggagc agcaagaggc tgggaagcca tcacttacct tgcactgaga aagaagacaa 60 aggccagtat gcacagcttt cctccactgc tgctgctgct gttctggggt gtggtgtctc 120 acagcttccc agcgactcta gaaacacaag agcaagatgt ggacttagtc cagaaatacc 180 tggaaaaata ctacaacctg aagaatgatg ggaggcaagt tgaaaagcgg agaaatagtg 240 gcccagtggt tgaaaaattg aagcaaatgc aggaattctt tgggctgaaa gtgactggga 300 aaccagatgc tgaaaccctg aaggtgatga agcagcccag atgtggagtg cctgatgtgg 360 ctcagtttgt cctcactgag gggaaccctc gctgggagca aacacatctg acctacagga 420 ttgaaaatta cacgccagat ttgccaagag cagatgtgga ccatgccatt gagaaagcct 480 tccaactctg gagtaatgtc acacctctga cattcaccaa ggtctctgag ggtcaagcag 540 acatcatgat atcttttgtc aggggagatc atcgggacaa ctctcctttt gatggacctg 600 gaggaaatct tgctcatgct tttcaaccag gcccaggtat tggaggggat gctcattttg 660 atgaagatga aaggtggacc aacaatttca gagagtacaa cttacatcgt gttgcagctc 720 atgaactcgg ccattctctt ggactctccc attctactga tatcggggct ttgatgtacc 780 ctagctacac cttcagtggt gatgttcagc tagctcagga tgacattgat ggcatccaag 840 ccatatatgg acgttcccaa aatcctgtcc agcccatcgg cccacaaacc ccaaaagcgt 900 gtgacagtaa gctaaccttt gatgctataa ctacgattcg gggagaagtg atgttcttta 960 aagacagatt ctacatgcgc acaaatccct tctacccgga agttgagctc aatttcattt 1020 ctgttttctg gccacaactg ccaaatgggc ttgaagctgc ttacgaattt gccgacagag 1080 atgaagtccg gtttttcaaa gggaataagt actgggctgt tcagggacag aatgtgctac 1140 acggataccc caaggacatc tacagctcct ttggcttccc tagaactgtg aagcatatcg 1200 atgctgctct ttctgaggaa aacactggaa aaacctactt ctttgttgct aacaaatact 1260 ggaggtatga tgaatataaa cgatctatgg atccaggtta tcccaaaatg atagcacatg 1320 actttcctgg aattggccac aaagttgatg cagttttcat gaaagatgga tttttctatt 1380 tctttcatgg aacaagacaa tacaaatttg atcctaaaac gaagagaatt ttgactctcc 1440 agaaagctaa tagctggttc aactgcagga aaaattgaac attactaatt tgaatggaaa 1500 acacatggtg tgagtccaaa gaaggtgttt tcctgaagaa ctgtctattt tctcagtcat 1560 ttttaacctc tagagtcact gatacacaga atataatctt atttatacct cagtttgcat 1620 atttttttac tatttagaat gtagcccttt ttgtactgat ataatttagt tccacaaatg 1680 gtgggtacaa aaagtcaagt ttgtggctta tggattcata taggccagag ttgcaaagat 1740 cttttccaga gtatgcaact ctgacgttga tcccagagag cagcttcagt gacaaacata 1800 tcctttcaag acagaaagag acaggagaca tgagtctttg ccggaggaaa agcagctcaa 1860 gaacacatgt gcagtcactg gtgtcaccct ggataggcaa gggataactc ttctaacaca 1920 aaataagtgt tttatgtttg gaataaagtc aaccttgttt ctactgtttt a 1971 <210> 244 <211> 3514 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3514) <223> MMP2 mRNA <400> 244 gctgcatcca gacttcctca ggcggtggct ggaggctgcg catctggggc tttaaacata 60 caaagggatt gccaggacct gcggcggcgg cggcggcggc gggggctggg gcgcgggggc 120 cggaccatga gccgctgagc cgggcaaacc ccaggccacc gagccagcgg accctcggag 180 cgcagccctg cgccgcggag caggctccaa ccaggcggcg aggcggccac acgcaccgag 240 ccagcgaccc ccgggcgacg cgcggggcca gggagcgcta cgatggaggc gctaatggcc 300 cggggcgcgc tcacgggtcc cctgagggcg ctctgtctcc tgggctgcct gctgagccac 360 gccgccgccg cgccgtcgcc catcatcaag ttccccggcg atgtcgcccc caaaacggac 420 aaagagttgg cagtgcaata cctgaacacc ttctatggct gccccaagga gagctgcaac 480 ctgtttgtgc tgaaggacac actaaagaag atgcagaagt tctttggact gccccagaca 540 ggtgatcttg accagaatac catcgagacc atgcggaagc cacgctgcgg caacccagat 600 gtggccaact acaacttctt ccctcgcaag cccaagtggg acaagaacca gatcacatac 660 aggatcattg gctacacacc tgatctggac ccagagacag tggatgatgc ctttgctcgt 720 gccttccaag tctggagcga tgtgacccca ctgcggtttt ctcgaatcca tgatggagag 780 gcagacatca tgatcaactt tggccgctgg gagcatggcg atggataccc ctttgacggt 840 aaggacggac tcctggctca tgccttcgcc ccaggcactg gtgttggggg agactcccat 900 tttgatgacg atgagctatg gaccttggga gaaggccaag tggtccgtgt gaagtatggg 960 aacgccgatg gggagtactg caagttcccc ttcttgttca atggcaagga gtacaacagc 1020 tgcactgata ccggccgcag cgatggcttc ctctggtgct ccaccaccta caactttgag 1080 aaggatggca agtacggctt ctgtccccat gaagccctgt tcaccatggg cggcaacgct 1140 gaaggacagc cctgcaagtt tccattccgc ttccagggca catcctatga cagctgcacc 1200 actgagggcc gcacggatgg ctaccgctgg tgcggcacca ctgaggacta cgaccgcgac 1260 aagaagtatg gcttctgccc tgagaccgcc atgtccactg ttggtgggaa ctcagaaggt 1320 gccccctgtg tcttcccctt cactttcctg ggcaacaaat atgagagctg caccagcgcc 1380 ggccgcagtg acggaaagat gtggtgtgcg accacagcca actacgatga tgaccgcaag 1440 tggggcttct gccctgacca agggtacagc ctgttcctcg tggcagccca cgagtttggc 1500 cacgccatgg ggctggagca ctcccaagac cctggggccc tgatggcacc catttacacc 1560 tacaccaaga acttccgtct gtcccaggat gacatcaagg gcattcagga gctctatggg 1620 gcctctcctg acattgacct tggcaccggc cccaccccca cgctgggccc tgtcactcct 1680 gagatctgca aacaggacat tgtatttgat ggcatcgctc agatccgtgg tgagatcttc 1740 ttcttcaagg accggttcat ttggcggact gtgacgccac gtgacaagcc catggggccc 1800 ctgctggtgg ccacattctg gcctgagctc ccggaaaaga ttgatgcggt atacgaggcc 1860 ccacaggagg agaaggctgt gttctttgca gggaatgaat actggatcta ctcagccagc 1920 accctggagc gagggtaccc caagccactg accagcctgg gactgccccc tgatgtccag 1980 cgagtggatg ccgcctttaa ctggagcaaa aacaagaaga catacatctt tgctggagac 2040 aaattctgga gatacaatga ggtgaagaag aaaatggatc ctggcttccc caagctcatc 2100 gcagatgcct ggaatgccat ccccgataac ctggatgccg tcgtggacct gcagggcggc 2160 ggtcacagct acttcttcaa gggtgcctat tacctgaagc tggagaacca aagtctgaag 2220 agcgtgaagt ttggaagcat caaatccgac tggctaggct gctgagctgg ccctggctcc 2280 cacaggccct tcctctccac tgccttcgat acaccgggcc tggagaacta gagaaggacc 2340 cggaggggcc tggcagccgt gccttcagct ctacagctaa tcagcattct cactcctacc 2400 tggtaattta agattccaga gagtggctcc tcccggtgcc caagaataga tgctgactgt 2460 actcctccca ggcgcccctt ccccctccaa tcccaccaac cctcagagcc acccctaaag 2520 agatactttg atattttcaa cgcagccctg ctttgggctg ccctggtgct gccacacttc 2580 aggctcttct cctttcacaa ccttctgtgg ctcacagaac ccttggagcc aatggagact 2640 gtctcaagag ggcactggtg gcccgacagc ctggcacagg gcagtgggac agggcatggc 2700 caggtggcca ctccagaccc ctggcttttc actgctggct gccttagaac ctttcttaca 2760 ttagcagttt gctttgtatg cactttgttt ttttctttgg gtcttgtttt ttttttccac 2820 ttagaaattg catttcctga cagaaggact caggttgtct gaagtcactg cacagtgcat 2880 ctcagcccac atagtgatgg ttcccctgtt cactctactt agcatgtccc taccgagtct 2940 cttctccact ggatggagga aaaccaagcc gtggcttccc gctcagccct ccctgcccct 3000 cccttcaacc attccccatg ggaaatgtca acaagtatga ataaagacac ctactgagtg 3060 gccgtgtttg ccatctgttt tagcagagcc tagacaaggg ccacagaccc agccagaagc 3120 ggaaacttaa aaagtccgaa tctctgctcc ctgcagggca caggtgatgg tgtctgctgg 3180 aaaggtcaga gcttccaaag taaacagcaa gagaacctca gggagagtaa gctctagtcc 3240 ctctgtcctg tagaaagagc cctgaagaat cagcaatttt gttgctttat tgtggcatct 3300 gttcgaggtt tgcttcctct ttaagtctgt ttcttcatta gcaatcatat cagttttaat 3360 gctactacta acaatgaaca gtaacaataa tatccccctc aattaataga gtgctttcta 3420 tgtgcaaggc acttttcacg tgtcacctat tttaaccttt ccaaccacat aaataaaaaa 3480 ggccattatt agttgaatct tattgatgaa gaga 3514 <210> 245 <211> 1906 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1906) <223> MMP3 mRNA <400> 245 aaagcaagga tgagtcaagc tgcgggtgat ccaaacaaac actgtcactc tttaaaagct 60 gcgctcccga ggttggacct acaaggaggc aggcaagaca gcaaggcata gagacaacat 120 agagctaagt aaagccagtg gaaatgaaga gtcttccaat cctactgttg ctgtgcgtgg 180 cagtttgctc agcctatcca ttggatggag ctgcaagggg tgaggacacc agcatgaacc 240 ttgttcagaa atatctagaa aactactacg acctcaaaaa agatgtgaaa cagtttgtta 300 ggagaaagga cagtggtcct gttgttaaaa aaatccgaga aatgcagaag ttccttggat 360 tggaggtgac ggggaagctg gactccgaca ctctggaggt gatgcgcaag cccaggtgtg 420 gagttcctga tgttggtcac ttcagaacct ttcctggcat cccgaagtgg aggaaaaccc 480 accttacata caggattgtg aattatacac cagatttgcc aaaagatgct gttgattctg 540 ctgttgagaa agctctgaaa gtctgggaag aggtgactcc actcacattc tccaggctgt 600 atgaaggaga ggctgatata atgatctctt ttgcagttag agaacatgga gacttttacc 660 cttttgatgg acctggaaat gttttggccc atgcctatgc ccctgggcca gggattaatg 720 gagatgccca ctttgatgat gatgaacaat ggacaaagga tacaacaggg accaatttat 780 ttctcgttgc tgctcatgaa attggccact ccctgggtct ctttcactca gccaacactg 840 aagctttgat gtacccactc tatcactcac tcacagacct gactcggttc cgcctgtctc 900 aagatgatat aaatggcatt cagtccctct atggacctcc ccctgactcc cctgagaccc 960 ccctggtacc cacggaacct gtccctccag aacctgggac gccagccaac tgtgatcctg 1020 ctttgtcctt tgatgctgtc agcactctga ggggagaaat cctgatcttt aaagacaggc 1080 acttttggcg caaatccctc aggaagcttg aacctgaatt gcatttgatc tcttcatttt 1140 ggccatctct tccttcaggc gtggatgccg catatgaagt tactagcaag gacctcgttt 1200 tcatttttaa aggaaatcaa ttctgggcta tcagaggaaa tgaggtacga gctggatacc 1260 caagaggcat ccacacccta ggtttccctc caaccgtgag gaaaatcgat gcagccattt 1320 ctgataagga aaagaacaaa acatatttct ttgtagagga caaatactgg agatttgatg 1380 agaagagaaa ttccatggag ccaggctttc ccaagcaaat agctgaagac tttccaggga 1440 ttgactcaaa gattgatgct gtttttgaag aatttgggtt cttttatttc tttactggat 1500 cttcacagtt ggagtttgac ccaaatgcaa agaaagtgac acacactttg aagagtaaca 1560 gctggcttaa ttgttgaaag agatatgtag aaggcacaat atgggcactt taaatgaagc 1620 taataattct tcacctaagt ctctgtgaat tgaaatgttc gttttctcct gcctgtgctg 1680 tgactcgagt cacactcaag ggaacttgag cgtgaatctg tatcttgccg gtcattttta 1740 tgttattaca gggcattcaa atgggctgct gcttagcttg caccttgtca catagagtga 1800 tctttcccaa gagaagggga agcactcgtg tgcaacagac aagtgactgt atctgtgtag 1860 actatttgct tatttaataa agacgatttg tcagttattt tatctt 1906 <210> 246 <211> 4593 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4593) <223> VISFATIN mRNA <400> 246 gctgccgcgc cccgcccttt ctcggccccc ggagggtgac ggggtgaagg cgggggaacc 60 gaggtgggga gtccgccaga gctcccagac tgcgagcacg cgagccgccg cagccgtcac 120 ccgcgccgcg tcacggctcc cgggcccgcc ctcctctgac ccctcccctc tctccgtttc 180 cccctctccc cctcctccgc cgaccgagca gtgacttaag caacggagcg cggtgaagct 240 catttttctc cttcctcgca gccgcgccag ggagctcgcg gcgcgcggcc cctgtcctcc 300 ggcccgagat gaatcctgcg gcagaagccg agttcaacat cctcctggcc accgactcct 360 acaaggttac tcactataaa caatatccac ccaacacaag caaagtttat tcctactttg 420 aatgccgtga aaagaagaca gaaaactcca aattaaggaa ggtgaaatat gaggaaacag 480 tattttatgg gttgcagtac attcttaata agtacttaaa aggtaaagta gtaaccaaag 540 agaaaatcca ggaagccaaa gatgtctaca aagaacattt ccaagatgat gtctttaatg 600 aaaagggatg gaactacatt cttgagaagt atgatgggca tcttccaata gaaataaaag 660 ctgttcctga gggctttgtc attcccagag gaaatgttct cttcacggtg gaaaacacag 720 atccagagtg ttactggctt acaaattgga ttgagactat tcttgttcag tcctggtatc 780 caatcacagt ggccacaaat tctagagagc agaagaaaat attggccaaa tatttgttag 840 aaacttctgg taacttagat ggtctggaat acaagttaca tgattttggc tacagaggag 900 tctcttccca agagactgct ggcataggag catctgctca cttggttaac ttcaaaggaa 960 cagatacagt agcaggactt gctctaatta aaaaatatta tggaacgaaa gatcctgttc 1020 caggctattc tgttccagca gcagaacaca gtaccataac agcttggggg aaagaccatg 1080 aaaaagatgc ttttgaacat attgtaacac agttttcatc agtgcctgta tctgtggtca 1140 gcgatagcta tgacatttat aatgcgtgtg agaaaatatg gggtgaagat ctaagacatt 1200 taatagtatc aagaagtaca caggcaccac taataatcag acctgattct ggaaaccctc 1260 ttgacactgt gttaaaggtt ttggagattt taggtaagaa gtttcctgtt actgagaact 1320 caaagggtta caagttgctg ccaccttatc ttagagttat tcaaggggat ggagtagata 1380 ttaatacctt acaagagatt gtagaaggca tgaaacaaaa aatgtggagt attgaaaata 1440 ttgccttcgg ttctggtgga ggtttgctac agaagttgac aagagatctc ttgaattgtt 1500 ccttcaagtg tagctatgtt gtaactaatg gccttgggat taacgtcttc aaggacccag 1560 ttgctgatcc caacaaaagg tccaaaaagg gccgattatc tttacatagg acgccagcag 1620 ggaattttgt tacactggag gaaggaaaag gagaccttga ggaatatggt caggatcttc 1680 tccatactgt cttcaagaat ggcaaggtga caaaaagcta ttcatttgat gaaataagaa 1740 aaaatgcaca gctgaatatt gaactggaag cagcacatca ttaggcttta tgactgggtg 1800 tgtgttgtgt gtatgtaata cataatgttt attgtacaga tgtgtggggt ttgtgtttta 1860 tgatacatta cagccaaatt atttgttggt ttatggacat actgcccttt catttttttt 1920 cttttccagt gtttaggtga tctcaaatta ggaaatgcat ttaaccatgt aaaagatgag 1980 tgctaaagta agctttttag ggccctttgc caataggtag tcattcaatc tggtattgat 2040 cttttcacaa ataacagaac tgagaaactt ttatatataa ctgatgatca cataaaacag 2100 atttgcataa aattaccatg attgctttat gtttatattt aacttgtatt tttgtacaaa 2160 caagattgtg taagatatat ttgaagtttc agtgatttaa cagtctttcc aacttttcat 2220 gatttttatg agcacagact ttcaagaaaa tacttgaaaa taaattacat tgccttttgt 2280 ccattaatca gcaaataaaa catggcctta acaaagttgt ttgtgttatt gtacaatttg 2340 aaaattatgt cgggacatac cctatagaat tactaacctt actgcccctt gtagaatatg 2400 tattaatcat tctacattaa agaaaataat ggttcttact ggaatgtcta ggcactgtac 2460 agttattata tatcttggtt gttgtattgt accagtgaaa tgccaaattt gaaaggcctg 2520 tactgcaatt ttatatgtca gagattgcct gtggctctaa tatgcacctc aagattttaa 2580 ggagataatg tttttagaga gaatttctgc ttccactata gaatatatac ataaatgtaa 2640 aatacttaca aaagtggaag tagtgtattt taaagtaatt acacttctga atttattttt 2700 catattctat agttggtatg acttaaatga attactggag tgggtagtga gtgtacttaa 2760 atgtttcaat tctgttatat tttttattaa gtttttaaaa aattaaattg gatattaaat 2820 tgtatggaca tcatttatta attttaaact gaatgccctc aataagtaat actgaagcac 2880 attcttaaat gaagataaat tatctccaat gaaaagcatg acatgtgttt caatagaaga 2940 atcttaagtt ggctaaattc aaagtgcttg acatcaaaat gttctagagt gattagctac 3000 tagattctga atcatacatc acatctgact agagaccagt ttctttcgaa tgattctttt 3060 atgtatgtag atctgttctt ctgaggcagc ggttggccaa ctatagccca aaggccaaat 3120 ttggacttct ttttataaat gcagattgtc tatggctgct ttcccactac tccagcctaa 3180 ggtaaacagc tgcaatagaa gccaaatgag aatcgcaaag cccaaaatgt ttattaacct 3240 gccctttaca caaaattaca caaaaagttt cctgatctct gttctaagaa aaggagtgtg 3300 ccttgcattt aaaaggaaat gttggtttct agggaaggga ggaggctaaa taattgatac 3360 ggaattttcc tcttttgtct tcttttttct cacttaagaa tccgatactg gaagactgat 3420 ttagaaaagt ttttaacatg acattaaatg tgaaatttta aaaattgaaa agccataaat 3480 catctgtttt aaatagttac atgagaaaat gatcactaga ataacctaat tagaagtgtt 3540 atcttcatta aatgtttttt gtaagtggta ttagaaagaa tatgtttttc agatggttct 3600 ttaaacatgt agtgagaaca ataagcatta ttcactttta gtaagtcttc tgtaatccat 3660 gatataaaat aattttaaaa tgatttttta atgtatttga gtaaagatga gtagtattaa 3720 gaaaaacaca catttcttca caaaatgtgc taaggggcgt gtaaagaatc aaaagaaact 3780 attaccaata atagttttga taatcaccca taattttgtg tttaaacatt gaaattatag 3840 tacagacagt attctctgtg ttctgtgaat ttcagcagct tcagaataga gtttaattta 3900 gaaatttgca gtgaaaaaag ctatctcttt gttcacaacc ataaatcagg agatggagat 3960 taattctatt ggctcttagt cacttggaac tgattaattc tgactttctg tcactaagca 4020 cttggtattt ggccatctcc attctgagca ccaaacggtt aacacgaatg tccactagaa 4080 ctctgctgtg tgtcaccctt aaatcagtct aaatcttcca gacaaaagca aatggcattt 4140 atggatttaa gtcattagat tttcaactga cattaattaa tccctcttga ttgattatat 4200 catcaagtat ttatatctta aataggaggt aggatttctg tgttaagact cttatttgta 4260 ccctataatt aaagtaaaat gttttttatg agtatccctt gttttccctt cttaaattgt 4320 tatcaaacaa tttttataat gaaatctatc ttggaaaatt agaaagaaaa atggcaaggt 4380 atttattgtt ctgtttgcca taatttagaa ctcacactta agtattttgt agttttacat 4440 tcctttttaa cccattcagt ggagaatgtc agcttttctc ccaagttgta tgttaagtct 4500 attctaatat gtactcaaca tcaagttata aacatgtaat aaacatggaa ataaagttta 4560 gctctattag tgaagtgtta aaaaaaaaaa aaa 4593 <210> 247 <211> 4020 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4020) <223> NPAS2 mRNA <400> 247 gcgtgcggaa gagtttgccg cgcgagcagc cggcctctcg caggagccga gggacccgcg 60 cggctgcggc ccaggagcgg cggccgcgga gcccggagac ccgcagccgc ggcggcggcg 120 gcggcggcgg cagcagctag agcagcgcct cccgccgccg cccgggagga gctcgccgcg 180 cccgctcgcc gcctcgtctc ccagcggcgg cgggaggcgc gtctccccgg cccagtccgc 240 gcccggcccc gcggggccgc tccggcccgc tccgaggaaa aactgcatag aaaatctaat 300 ggatgaagat gagaaagaca gagccaagag agcttctcga aacaagtctg agaagaagcg 360 tcgggaccag ttcaatgttc tcatcaaaga gctcagttcc atgctccctg gcaacacgcg 420 gaaaatggac aaaaccaccg tgttggaaaa ggtcatcgga tttttgcaga aacacaatga 480 agtctcagcg caaacggaaa tctgtgacat tcagcaagac tggaagcctt cattcctcag 540 taatgaagaa ttcacccagc tgatgttgga ggcattagat ggcttcatta tcgcagtgac 600 aacagacggc agcatcatct atgtctctga cagtatcacg cctctccttg ggcatttacc 660 gtcggatgtc atggatcaga atttgttaaa tttcctccca gaacaagaac attcagaagt 720 ttataaaatc ctttcttccc atatgcttgt gacggattcc ccctccccag aatacttaaa 780 atctgacagc gatttagagt tttattgcca tcttctcaga ggcagcttga acccaaagga 840 atttccaact tatgaataca taaaatttgt aggaaatttt cgctcttaca acaatgtgcc 900 tagcccctcc tgtaatggtt ttgacaacac cctttcaaga ccttgccggg tgccactagg 960 aaaggaggtt tgcttcattg ccaccgttcg tctggcaaca ccacaattct taaaggaaat 1020 gtgcatagtt gacgaacctt tagaggaatt cacttcaagg catagcttgg aatggaaatt 1080 tttatttctg gatcacagag cacctccaat cataggatac ctgccttttg aagtgctggg 1140 aacctcaggc tatgactact accacattga tgacctggag ctcctggcca ggtgtcacca 1200 gcacctgatg cagtttggca aagggaagtc gtgttgctac cggtttctga ccaaaggtca 1260 gcagtggatc tggctgcaga ctcactacta catcacctac catcagtgga actccaagcc 1320 cgagttcatc gtgtgcacac actcggtggt cagttacgca gatgtccggg tggaaaggag 1380 gcaggagctg gctctggaag acccgccatc cgaggccctc cactcctcag cactaaagga 1440 caagggctca agcctggaac ctcggcagca ctttaacaca ctcgacgtgg gtgcctcggg 1500 ccttaatacc agtcattcgc catcggcgtc ctcaagaagt tcccacaaat cctcgcacac 1560 agccatgtca gaacccacct ccactcccac caagctgatg gcagaggcca gcaccccggc 1620 tttgccaaga tcagccaccc tgccccaaga gttacctgtc cccgggctca gccaggcagc 1680 caccatgccg gcccctctgc cttccccatc gtcctgcgac ctcacacagc agctcctgcc 1740 tcagaccgtt ctgcagagca cgcccgctcc catggcacag ttttcggcac agttcagcat 1800 gttccagacc atcaaagacc agctagagca gcggacgcgg atcctgcagg ccaatatccg 1860 gtggcaacag gaagagctcc acaagatcca ggagcagctc tgcctggtcc aggactccaa 1920 cgtccagatg ttcctgcagc agccagctgt atccctgagc ttcagcagca cccagcgacc 1980 tgaggctcag cagcagctac agcaaaggtc agctgcagtg actcagcccc agctcggggc 2040 gggcccccaa cttccagggc agatctcctc tgcccaggtc acaagccagc acctgctcag 2100 agaatcaagt gtgatatcaa cccagggtcc aaagccaatg agaagctcac agctaatgca 2160 gagcagcggc cgctctggaa gcagcctagt gtccccgttc agcagcgcca cagctgcgct 2220 cccgccaagt ctgaatctga ccacacctgc ttccacctcc caggatgcca gccagtgcca 2280 gcccagccca gacttcagcc atgatcggca gctcaggctg ttgctgagcc agcccatcca 2340 gcccatgatg cccgggtcct gtgacgcaag gcagccctcg gaagtcagca ggacgggacg 2400 gcaagtcaag tacgcccaga gccagaccgt gtttcaaaat ccagacgcac accccgccaa 2460 cagcagcagc gccccgatgc ccgtcctgct gatggggcag gcggtgctcc accccagctt 2520 ccctgcctcc caaccatcgc ccctgcagcc tgcacaggcc cggcagcagc caccgcagca 2580 ctacctgcag gtacaggcac caacctcttt gcacagtgag cagcaggact cgctacttct 2640 ctccacctac tcacaacagc cagggaccct gggctacccc caaccacccc cagcacagcc 2700 ccagccccta cgtcctcccc gaagggtcag cagtctgtct gagtcgtcag gcctccagca 2760 gccgccccga taatgccccg gcactgaagt cgggacacaa tcagctttaa ccaatggatg 2820 aggggggtgg ccacaggaga tggggagagg agtctgaact aaacccctgg cttttgtgca 2880 cactgcatac gtttcagaac tcctggatgg taaccatctc tggagtgcag cgcttgctgc 2940 agtggaaatg atcaggaata ctgaccgtgt ttctcttgcc tccgaggttc ttgggcacac 3000 tctatagcca tactggacag gaaccaggtg ccccgtgtag gcatcgtcgg tcggtttgcc 3060 gtcagagatg gcgcatctcg ctgcatcccc cgagagtaca ccggttgctc tagccacctg 3120 cggcccgccc atctgcgcta gctggccttc acgctcttga tcgtctttcc tttgtattgg 3180 agaaggactg ggtcagagat ctgttggaga gagagaataa agagattatt tttcattatt 3240 tttaaatggt tgtttttgtt ttaatttgca cagctacaca gaggaaataa cttaggcact 3300 ttctgttttt tttaaaaaaa taataaggtc tcatggcttc atttagagac cacagtaaca 3360 acagcagccc accaatcaga gaagctggtt gttattaacc aagctacaga ttcacacttt 3420 ctggcctaaa ccctaatggg atgaggcttt tcaccccagg ccatgctggt ggtgattttt 3480 tagcccctaa ataaaacact ggactatttc ctgtttactt cattgattgc aactacaaag 3540 gtggactcaa agcaaagcac aatcatgcca gccaacattc cagaattctg ctgagaactc 3600 caagtctgtg aggggagagg ttttacaagc cagacaggcc tgggggactg cagtccccaa 3660 ggagaccctg ccacatgctg gccctttgag tgagaatgct gcatctttct acatatcttc 3720 atgagaatac tgagaattgg attttccttt tcaaaatgca ctttgctttt tttgtatgtt 3780 ttgttatgtt gagatgtttc taaagaaaag attttatgta attataagat gaagcgtagt 3840 gaattgtaca gctgttgtaa taatgaccta tttctatata aaataaaatt gtatggctta 3900 tgtgtaaatt attttgtatc tgagatacca gttccttttc ccaaatataa aagtataaaa 3960 gttttcttgt gtttttctgt gagtgaaaat tttgtaataa attaacaaat ttgtacaatt 4020 4020 <210> 248 <211> 2809 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2809) <223> PDGFA mRNA <400> 248 acgcgcgccc tgcggagccc gcccaactcc ggcgagccgg gcctgcgcct actcctcctc 60 ctcctctccc ggcggcggct gcggcggagg cgccgactcg gccttgcgcc cgccctcagg 120 cccgcgcggg cggcgcagcg aggccccggg cggcgggtgg tggctgccag gcggctcggc 180 cgcgggcgct gcccggcccc ggcgagcgga gggcggagcg cggcgccgga gccgagggcg 240 cgccgcggag ggggtgctgg gccgcgctgt gcccggccgg gcggcggctg caagaggagg 300 ccggaggcga gcgcggggcc ggcggtgggc gcgcagggcg gctcgcagct cgcagccggg 360 gccgggccag gcgtccaggc aggtgatcgg tgtggcggcg gcggcggcgg cggccccaga 420 ctccctccgg agttcttctt ggggctgatg tccgcaaata tgcagaatta ccggccgggt 480 cgctcctgaa gccagcgcgg ggagcgagcg cggcggcggc cagcaccggg aacgcaccga 540 ggaagaagcc cagcccccgc cctccgcccc ttccgtcccc accccctacc cggcggccca 600 ggaggctccc cgcgctgcgg gcgcgcactc cctgtttctc ctcctcctgg ctggcgctgc 660 ctgcctctcc gcactcactg ctcgcgccgg gcgcgctccg ccagctccgt gctccccgcg 720 ccaccctcct ccgggccgcg ctccctaagg gatggtactg aatttcgccg ccacaggaga 780 ccggctggag cgcccgcccc gcggcctcgc ctctcctccg agcagccagc gcctcgggac 840 gcgatgagga ccttggcttg cctgctgctc ctcggctgcg gatacctcgc ccatgttctg 900 gccgaggaag ccgagatccc ccgcgaggtg atcgagaggc tggcccgcag tcagatccac 960 agcatccggg acctccagcg actcctggag atagactccg tagggagtga ggattctttg 1020 gacaccagcc tgagagctca cggggtccat gccactaagc atgtgcccga gaagcggccc 1080 ctgcccattc ggaggaagag aagcatcgag gaagctgtcc ccgctgtctg caagaccagg 1140 acggtcattt acgagattcc tcggagtcag gtcgacccca cgtccgccaa cttcctgatc 1200 tggcccccgt gcgtggaggt gaaacgctgc accggctgct gcaacacgag cagtgtcaag 1260 tgccagccct cccgcgtcca ccaccgcagc gtcaaggtgg ccaaggtgga atacgtcagg 1320 aagaagccaa aattaaaaga agtccaggtg aggttagagg agcatttgga gtgcgcctgc 1380 gcgaccacaa gcctgaatcc ggattatcgg gaagaggaca cgggaaggcc tagggagtca 1440 ggtaaaaaac ggaaaagaaa aaggttaaaa cccacctaaa gcagccaacc agatgtgagg 1500 tgaggatgag ccgcagccct ttcctgggac atggatgtac atggcgtgtt acattcctga 1560 acctactatg tacggtgctt tattgccagt gtgcggtctt tgttctcctc cgtgaaaaac 1620 tgtgtccgag aacactcggg agaacaaaga gacagtgcac atttgtttaa tgtgacatca 1680 aagcaagtat tgtagcactc ggtgaagcag taagaagctt ccttgtcaaa aagagagaga 1740 gagaaagaga gagagaaaac aaaaccacaa atgacaaaaa caaaacggac tcacaaaaat 1800 atctaaactc gatgagatgg agggtcgccc cgtgggatgg aagtgcagag gtctcagcag 1860 actggatttc tgtccgggtg gtcacaggtg cttttttgcc gaggatgcag agcctgcttt 1920 gggaacgact ccagaggggt gctggtgggc tctgcagggg cccgcaggaa gcaggaatgt 1980 cttggaaacc gccacgcgaa ctttagaaac cacacctcct cgctgtagta tttaagccca 2040 tacagaaacc ttcctgagag ccttaagtgg tttttttttt tgtttttgtt ttgttttttt 2100 tttttttgtt tttttttttt tttttttaca ccataaagtg attattaagc tttccttttt 2160 actctttggc tagctttttt tttttttttt tttttttaat tatctcttgg atgacattta 2220 caccgataac acacaggctg ctgtaactgt caggacagtg cgacggtatt tttcctagca 2280 agatgcaaac taatgagatg tattaaaata aacatggtat acctacctat gcatcatttc 2340 ctaaatgttt ctggctttgt gtttctccct taccctgctt tatttgttaa tttaagccat 2400 tttgaaagaa ctatgcgtca accaatcgta cgccgtccct gcggcacctg ccccagagcc 2460 cgtttgtggc tgagtgacaa cttgttcccc gcagtgcaca cctagaatgc tgtgttccca 2520 cgcggcacgt gagatgcatt gccgcttctg tctgtgttgt tggtgtgccc tggtgccgtg 2580 gtggcggtca ctccctctgc tgccagtgtt tggacagaac ccaaattctt tatttttggt 2640 aagatattgt gctttacctg tattaacaga aatgtgtgtg tgtggtttgt ttttttgtaa 2700 aggtgaagtt tgtatgttta cctaatatta cctgttttgt atacctgaga gcctgctatg 2760 ttcttttttt gttgatccaa aattaaaaaa aaaaatacca ccaacaaaa 2809 <210> 249 <211> 3221 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3221) <223> PLAT mRNA <400> 249 gaacttcctc cccctgcttt ataaaaacag gcctgcctca gctccctcat ggccctgtcc 60 actgagcatc ctcccgccac acagaaaccc gcccagccgg ggccaccgac cccaccccct 120 gcctggaaac ttaaaggagg ccggagctgt ggggagctca gagctgagat cctacaggag 180 tccagggctg gagagaaaac ctctgcgagg aaagggaagg agcaagccgt gaatttaagg 240 gacgctgtga agcaatcatg gatgcaatga agagagggct ctgctgtgtg ctgctgctgt 300 gtggagcagt cttcgtttcg cccagccagg aaatccatgc ccgattcaga agaggagcca 360 gatcttacca agtgatctgc agagatgaaa aaacgcagat gatataccag caacatcagt 420 catggctgcg ccctgtgctc agaagcaacc gggtggaata ttgctggtgc aacagtggca 480 gggcacagtg ccactcagtg cctgtcaaaa gttgcagcga gccaaggtgt ttcaacgggg 540 gcacctgcca gcaggccctg tacttctcag atttcgtgtg ccagtgcccc gaaggatttg 600 ctgggaagtg ctgtgaaata gataccaggg ccacgtgcta cgaggaccag ggcatcagct 660 acaggggcac gtggagcaca gcggagagtg gcgccgagtg caccaactgg aacagcagcg 720 cgttggccca gaagccctac agcgggcgga ggccagacgc catcaggctg ggcctgggga 780 accacaacta ctgcagaaac ccagatcgag actcaaagcc ctggtgctac gtctttaagg 840 cggggaagta cagctcagag ttctgcagca cccctgcctg ctctgaggga aacagtgact 900 gctactttgg gaatgggtca gcctaccgtg gcacgcacag cctcaccgag tcgggtgcct 960 cctgcctccc gtggaattcc atgatcctga taggcaaggt ttacacagca cagaacccca 1020 gtgcccaggc actgggcctg ggcaaacata attactgccg gaatcctgat ggggatgcca 1080 agccctggtg ccacgtgctg aagaaccgca ggctgacgtg ggagtactgt gatgtgccct 1140 cctgctccac ctgcggcctg agacagtaca gccagcctca gtttcgcatc aaaggagggc 1200 tcttcgccga catcgcctcc cacccctggc aggctgccat ctttgccaag cacaggaggt 1260 cgcccggaga gcggttcctg tgcgggggca tactcatcag ctcctgctgg attctctctg 1320 ccgcccactg cttccaggag aggtttccgc cccaccacct gacggtgatc ttgggcagaa 1380 cataccgggt ggtccctggc gaggaggagc agaaatttga agtcgaaaaa tacattgtcc 1440 ataaggaatt cgatgatgac acttacgaca atgacattgc gctgctgcag ctgaaatcgg 1500 attcgtcccg ctgtgcccag gagagcagcg tggtccgcac tgtgtgcctt cccccggcgg 1560 acctgcagct gccggactgg acggagtgtg agctctccgg ctacggcaag catgaggcct 1620 tgtctccttt ctattcggag cggctgaagg aggctcatgt cagactgtac ccatccagcc 1680 gctgcacatc acaacattta cttaacagaa cagtcaccga caacatgctg tgtgctggag 1740 acactcggag cggcgggccc caggcaaact tgcacgacgc ctgccagggc gattcgggag 1800 gccccctggt gtgtctgaac gatggccgca tgactttggt gggcatcatc agctggggcc 1860 tgggctgtgg acagaaggat gtcccgggtg tgtacaccaa ggttaccaac tacctagact 1920 ggattcgtga caacatgcga ccgtgaccag gaacacccga ctcctcaaaa gcaaatgaga 1980 tcccgcctct tcttcttcag aagacactgc aaaggcgcag tgcttctcta cagacttctc 2040 cagacccacc acaccgcaga agcgggacga gaccctacag gagagggaag agtgcatttt 2100 cccagatact tcccattttg gaagttttca ggacttggtc tgatttcagg atactctgtc 2160 agatgggaag acatgaatgc acactagcct ctccaggaat gcctcctccc tgggcagaaa 2220 gtggccatgc caccctgttt tcagctaaag cccaacctcc tgacctgtca ccgtgagcag 2280 ctttggaaac aggaccacaa aaatgaaagc atgtctcaat agtaaaagat aacaagatct 2340 ttcaggaaag acggattgca ttagaaatag acagtatatt tatagtcaca agagcccagc 2400 agggcctcaa agttggggca ggctggctgg cccgtcatgt tcctcaaaag cacccttgac 2460 gtcaagtctc cttccccttt ccccactccc tggctctcag aaggtattcc ttttgtgtac 2520 agtgtgtaaa gtgtaaatcc tttttcttta taaactttag agtagcatga gagaattgta 2580 tcatttgaac aactaggctt cagcatattt atagcaatcc atgttagttt ttactttctg 2640 ttgccacaac cctgttttat actgtactta ataaattcag atatattttt cacagttttt 2700 ccaaaatcag agtggaatgg ttttgttata gatgctgtat cccactcttt attcatgttc 2760 acattttaaa atcatttgga attctgcttc actcgcttaa catatacaca acacctgtaa 2820 catacaaggc aatgggctag gtgctccaga ccgggaaaag gagggacagg aatgcttggt 2880 ctgatgggct aatatggcat ttagagaagt accaaggtac agtggagccg gtcacaaaag 2940 ggcagacttg tagtagaatt cagttgcaag agggattggg gaatcttaag gaaaaaatag 3000 aatcttaagg aaaaaataac tgggtgagac gtggactgtg gacaggtgtg gaaaaggcac 3060 tctccatgga ggtatgaata tgtagagggc caagagaggg gagtacaggg agaaatgagt 3120 tgagcttgtc tgaagtgaac ttcaggaaga ggaacatagg ctggaattta gattatgggg 3180 gctctgaaca ccaaactgag tttggactta attgacttct g 3221 <210> 250 <211> 2398 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2398) <223> PLAU mRNA <400> 250 ctgatataga gcaggcgccg cgggtcgcag cacagtgcgg agaccgcagc cccggagccc 60 gggccagggt ccacctgtcc ccgcagcgcc ggctcgcgcc ctcctgccgc agccaccgag 120 ccgccgtcta gcgccccgac ctcgccacca tgagagccct gctggcgcgc ctgcttctct 180 gcgtcctggt cgtgagcgac tccaaaggca gcaatgaact tcatcaagtt ccatcgaact 240 gtgactgtct aaatggagga acatgtgtgt ccaacaagta cttctccaac attcactggt 300 gcaactgccc aaagaaattc ggagggcagc actgtgaaat agataagtca aaaacctgct 360 atgaggggaa tggtcacttt taccgaggaa aggccagcac tgacaccatg ggccggccct 420 gcctgccctg gaactctgcc actgtccttc agcaaacgta ccatgcccac agatctgatg 480 ctcttcagct gggcctgggg aaacataatt actgcaggaa cccagacaac cggaggcgac 540 cctggtgcta tgtgcaggtg ggcctaaagc cgcttgtcca agagtgcatg gtgcatgact 600 gcgcagatgg aaaaaagccc tcctctcctc cagaagaatt aaaatttcag tgtggccaaa 660 agactctgag gccccgcttt aagattattg ggggagaatt caccaccatc gagaaccagc 720 cctggtttgc ggccatctac aggaggcacc gggggggctc tgtcacctac gtgtgtggag 780 gcagcctcat cagcccttgc tgggtgatca gcgccacaca ctgcttcatt gattacccaa 840 agaaggagga ctacatcgtc tacctgggtc gctcaaggct taactccaac acgcaagggg 900 agatgaagtt tgaggtggaa aacctcatcc tacacaagga ctacagcgct gacacgcttg 960 ctcaccacaa cgacattgcc ttgctgaaga tccgttccaa ggagggcagg tgtgcgcagc 1020 catcccggac tatacagacc atctgcctgc cctcgatgta taacgatccc cagtttggca 1080 caagctgtga gatcactggc tttggaaaag agaattctac cgactatctc tatccggagc 1140 agctgaaaat gactgttgtg aagctgattt cccaccggga gtgtcagcag ccccactact 1200 acggctctga agtcaccacc aaaatgctgt gtgctgctga cccacagtgg aaaacagatt 1260 cctgccaggg agactcaggg ggacccctcg tctgttccct ccaaggccgc atgactttga 1320 ctggaattgt gagctggggc cgtggatgtg ccctgaagga caagccaggc gtctacacga 1380 gagtctcaca cttcttaccc tggatccgca gtcacaccaa ggaagagaat ggcctggccc 1440 tctgagggtc cccagggagg aaacgggcac cacccgcttt cttgctggtt gtcatttttg 1500 cagtagagtc atctccatca gctgtaagaa gagactggga agataggctc tgcacagatg 1560 gatttgcctg tgccacccac cagggcgaac gacaatagct ttaccctcag gcataggcct 1620 gggtgctggc tgcccagacc cctctggcca ggatggaggg gtggtcctga ctcaacatgt 1680 tactgaccag caacttgtct ttttctggac tgaagcctgc aggagttaaa aagggcaggg 1740 catctcctgt gcatgggtga agggagagcc agctcccccg acggtgggca tttgtgaggc 1800 ccatggttga gaaatgaata atttcccaat taggaagtgt aacagctgag gtctcttgag 1860 ggagcttagc caatgtggga gcagcggttt ggggagcaga gacactaacg acttcagggc 1920 agggctctga tattccatga atgtatcagg aaatatatat gtgtgtgtat gtttgcacac 1980 ttgtgtgtgg gctgtgagtg taagtgtgag taagagctgg tgtctgattg ttaagtctaa 2040 atatttcctt aaactgtgtg gactgtgatg ccacacagag tggtctttct ggagaggtta 2100 taggtcactc ctggggcctc ttgggtcccc cacgtgacag tgcctgggaa tgtattattc 2160 tgcagcatga cctgtgacca gcactgtctc agtttcactt tcacatagat gtccctttct 2220 tggccagtta tcccttcctt ttagcctagt tcatccaatc ctcactgggt ggggtgagga 2280 ccactcctgt acactgaata tttatatttc actattttta tttatatttt tgtaatttta 2340 aataaaagtg atcaataaaa tgtgattttt ctgatgacaa aaaaaaaaaa aaaaaaaa 2398 <210> 251 <211> 1368 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1368) <223> PLAUR mRNA <400> 251 aggagagaag acgtgcaggg accccgcgca caggagctgc cctcgcgaca tgggtcaccc 60 gccgctgctg ccgctgctgc tgctgctcca cacctgcgtc ccagcctctt ggggcctgcg 120 gtgcatgcag tgtaagacca acggggattg ccgtgtggaa gagtgcgccc tgggacagga 180 cctctgcagg accacgatcg tgcgcttgtg ggaagaagga gaagagctgg agctggtgga 240 gaaaagctgt acccactcag agaagaccaa caggaccctg agctatcgga ctggcttgaa 300 gatcaccagc cttaccgagg ttgtgtgtgg gttagacttg tgcaaccagg gcaactctgg 360 ccgggctgtc acctattccc gaagccgtta cctcgaatgc atttcctgtg gctcatcaga 420 catgagctgt gagaggggcc ggcaccagag cctgcagtgc cgcagccctg aagaacagtg 480 cctggatgtg gtgacccact ggatccagga aggtgaagaa gggcgtccaa aggatgaccg 540 ccacctccgt ggctgtggct accttcccgg ctgcccgggc tccaatggtt tccacaacaa 600 cgacaccttc cacttcctga aatgctgcaa caccaccaaa tgcaacgagg gcccaatcct 660 ggagcttgaa aatctgccgc agaatggccg ccagtgttac agctgcaagg ggaacagcac 720 ccatggatgc tcctctgaag agactttcct cattgactgc cgaggcccca tgaatcaatg 780 tctggtagcc accggcactc acgaaccgaa aaaccaaagc tatatggtaa gaggctgtgc 840 aaccgcctca atgtgccaac atgcccacct gggtgacgcc ttcagcatga accacattga 900 tgtctcctgc tgtactaaaa gtggctgtaa ccacccagac ctggatgtcc agtaccgcag 960 tggggctgct cctcagcctg gccctgccca tctcagcctc accatcaccc tgctaatgac 1020 tgccagactg tggggaggca ctctcctctg gacctaaacc tgaaatcccc ctctctgccc 1080 tggctggatc cgggggaccc ctttgccctt ccctcggctc ccagccctac agacttgctg 1140 tgtgacctca ggccagtgtg ccgacctctc tgggcctcag ttttcccagc tatgaaaaca 1200 gctatctcac aaagttgtgt gaagcagaag agaaaagctg gaggaaggcc gtgggccaat 1260 gggagagctc ttgttattat taatattgtt gccgctgttg tgttgttgtt attaattaat 1320 attcatatta tttattttat acttacataa agattttgta ccagtgga 1368 <210> 252 <211> 3538 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3538) <223> PLG mRNA <400> 252 gaatcattaa cttaatttga ctatctggtt tgtggatgcg tttactctca tgtaagtcaa 60 caacatcctg ggattgggac ccactttctg ggcactgctg gccagtccca aaatggaaca 120 taaggaagtg gttcttctac ttcttttatt tctgaaatca ggtcaaggag agcctctgga 180 tgactatgtg aatacccagg gggcttcact gttcagtgtc actaagaagc agctgggagc 240 aggaagtata gaagaatgtg cagcaaaatg tgaggaggac gaagaattca cctgcagggc 300 attccaatat cacagtaaag agcaacaatg tgtgataatg gctgaaaaca ggaagtcctc 360 cataatcatt aggatgagag atgtagtttt atttgaaaag aaagtgtatc tctcagagtg 420 caagactggg aatggaaaga actacagagg gacgatgtcc aaaacaaaaa atggcatcac 480 ctgtcaaaaa tggagttcca cttctcccca cagacctaga ttctcacctg ctacacaccc 540 ctcagaggga ctggaggaga actactgcag gaatccagac aacgatccgc aggggccctg 600 gtgctatact actgatccag aaaagagata tgactactgc gacattcttg agtgtgaaga 660 ggaatgtatg cattgcagtg gagaaaacta tgacggcaaa atttccaaga ccatgtctgg 720 actggaatgc caggcctggg actctcagag cccacacgct catggataca ttccttccaa 780 atttccaaac aagaacctga agaagaatta ctgtcgtaac cccgataggg agctgcggcc 840 ttggtgtttc accaccgacc ccaacaagcg ctgggaactt tgtgacatcc cccgctgcac 900 aacacctcca ccatcttctg gtcccaccta ccagtgtctg aagggaacag gtgaaaacta 960 tcgcgggaat gtggctgtta ccgtgtccgg gcacacctgt cagcactgga gtgcacagac 1020 ccctcacaca cataacagga caccagaaaa cttcccctgc aaaaatttgg atgaaaacta 1080 ctgccgcaat cctgacggaa aaagggcccc atggtgccat acaaccaaca gccaagtgcg 1140 gtgggagtac tgtaagatac cgtcctgtga ctcctcccca gtatccacgg aacaattggc 1200 tcccacagca ccacctgagc taacccctgt ggtccaggac tgctaccatg gtgatggaca 1260 gagctaccga ggcacatcct ccaccaccac cacaggaaag aagtgtcagt cttggtcatc 1320 tatgacacca caccggcacc agaagacccc agaaaactac ccaaatgctg gcctgacaat 1380 gaactactgc aggaatccag atgccgataa aggcccctgg tgttttacca cagaccccag 1440 cgtcaggtgg gagtactgca acctgaaaaa atgctcagga acagaagcga gtgttgtagc 1500 acctccgcct gttgtcctgc ttccagatgt agagactcct tccgaagaag actgtatgtt 1560 tgggaatggg aaaggatacc gaggcaagag ggcgaccact gttactggga cgccatgcca 1620 ggactgggct gcccaggagc cccatagaca cagcattttc actccagaga caaatccacg 1680 ggcgggtctg gaaaaaaatt actgccgtaa ccctgatggt gatgtaggtg gtccctggtg 1740 ctacacgaca aatccaagaa aactttacga ctactgtgat gtccctcagt gtgcggcccc 1800 ttcatttgat tgtgggaagc ctcaagtgga gccgaagaaa tgtcctggaa gggttgtagg 1860 ggggtgtgtg gcccacccac attcctggcc ctggcaagtc agtcttagaa caaggtttgg 1920 aatgcacttc tgtggaggca ccttgatatc cccagagtgg gtgttgactg ctgcccactg 1980 cttggagaag tccccaaggc cttcatccta caaggtcatc ctgggtgcac accaagaagt 2040 gaatctcgaa ccgcatgttc aggaaataga agtgtctagg ctgttcttgg agcccacacg 2100 aaaagatatt gccttgctaa agctaagcag tcctgccgtc atcactgaca aagtaatccc 2160 agcttgtctg ccatccccaa attatgtggt cgctgaccgg accgaatgtt tcatcactgg 2220 ctggggagaa acccaaggta cttttggagc tggccttctc aaggaagccc agctccctgt 2280 gattgagaat aaagtgtgca atcgctatga gtttctgaat ggaagagtcc aatccaccga 2340 actctgtgct gggcatttgg ccggaggcac tgacagttgc cagggtgaca gtggaggtcc 2400 tctggtttgc ttcgagaagg acaaatacat tttacaagga gtcacttctt ggggtcttgg 2460 ctgtgcacgc cccaataagc ctggtgtcta tgttcgtgtt tcaaggtttg ttacttggat 2520 tgagggagtg atgagaaata attaattgga cgggagacag agtgacgcac tgactcacct 2580 agaggctgga acgtgggtag ggatttagca tgctggaaat aactggcagt aatcaaacga 2640 agacactgtc cccagctacc agctacgcca aacctcggca ttttttgtgt tattttctga 2700 ctgctggatt ctgtagtaag gtgacatagc tatgacattt gttaaaaata aactctgtac 2760 ttaactttga tttgagtaaa ttttggtttt ggtcttcaac attttcatgc tctttgttca 2820 ccccaccaat ttttaaatgg gcagatgggg ggatttagct gcttttgata aggaacagct 2880 gcacaaagga ctgagcaggc tgcaaggtca cagaggggag agccaagaag ttgtccacgc 2940 atttacctca tcagctaacg agggcttgac atgcattttt actgtcttta ttcctgacac 3000 tgagatgaat gttttcaaag ctgcaacatg tatggggagt catgcaaacc gattctgtta 3060 ttgggaatga aatctgtcac cgactgcttg acttgagccc aggggacacg gagcagagag 3120 ctgtatatga tggagtgaac cggtccatgg atgtgtaaca caagaccaac tgagagtctg 3180 aatgttattc tggggcacac gtgagtctag gattggtgcc aagagcatgt aaatgaacaa 3240 caagcaaata ttgaaggtgg accacttatt tcccattgct aattgcctgc ccggttttga 3300 aacagtctgc agtacacacg gtcacaggag aatgacctgt gggagagata catgtttaga 3360 aggaagagaa aggacaaagg cacacgtttt accatttaaa atattgttac caaacaaaaa 3420 tatccattca aaatacaatt taacaatgca acagtcatct tacagcagag aaatgcagag 3480 aaaagcaaaa ctgcaagtga ctgtgaataa agggtgaatg tagtctcaaa tcctcaaa 3538 <210> 253 <211> 8718 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(8718) <223> PTEN mRNA <400> 253 cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc 60 ttccgaggcg cccgggctcc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggt 120 gatgtggcgg gactctttat gcgctgcggc aggatacgcg ctcggcgctg ggacgcgact 180 gcgctcagtt ctctcctctc ggaagctgca gccatgatgg aagtttgaga gttgagccgc 240 tgtgaggcga ggccgggctc aggcgaggga gatgagagac ggcggcggcc gcggcccgga 300 gcccctctca gcgcctgtga gcagccgcgg gggcagcgcc ctcggggagc cggccggcct 360 gcggcggcgg cagcggcggc gtttctcgcc tcctcttcgt cttttctaac cgtgcagcct 420 cttcctcggc ttctcctgaa agggaaggtg gaagccgtgg gctcgggcgg gagccggctg 480 aggcgcggcg gcggcggcgg cacctcccgc tcctggagcg ggggggagaa gcggcggcgg 540 cggcggccgc ggcggctgca gctccaggga gggggtctga gtcgcctgtc accatttcca 600 gggctgggaa cgccggagag ttggtctctc cccttctact gcctccaaca cggcggcggc 660 ggcggcggca catccaggga cccgggccgg ttttaaacct cccgtccgcc gccgccgcac 720 cccccgtggc ccgggctccg gaggccgccg gcggaggcag ccgttcggag gattattcgt 780 cttctcccca ttccgctgcc gccgctgcca ggcctctggc tgctgaggag aagcaggccc 840 agtcgctgca accatccagc agccgccgca gcagccatta cccggctgcg gtccagagcc 900 aagcggcggc agagcgaggg gcatcagcta ccgccaagtc cagagccatt tccatcctgc 960 agaagaagcc ccgccaccag cagcttctgc catctctctc ctcctttttc ttcagccaca 1020 ggctcccaga catgacagcc atcatcaaag agatcgttag cagaaacaaa aggagatatc 1080 aagaggatgg attcgactta gacttgacct atatttatcc aaacattatt gctatgggat 1140 ttcctgcaga aagacttgaa ggcgtataca ggaacaatat tgatgatgta gtaaggtttt 1200 tggattcaaa gcataaaaac cattacaaga tatacaatct ttgtgctgaa agacattatg 1260 acaccgccaa atttaattgc agagttgcac aatatccttt tgaagaccat aacccaccac 1320 agctagaact tatcaaaccc ttttgtgaag atcttgacca atggctaagt gaagatgaca 1380 atcatgttgc agcaattcac tgtaaagctg gaaagggacg aactggtgta atgatatgtg 1440 catatttatt acatcggggc aaatttttaa aggcacaaga ggccctagat ttctatgggg 1500 aagtaaggac cagagacaaa aagggagtaa ctattcccag tcagaggcgc tatgtgtatt 1560 attatagcta cctgttaaag aatcatctgg attatagacc agtggcactg ttgtttcaca 1620 agatgatgtt tgaaactatt ccaatgttca gtggcggaac ttgcaatcct cagtttgtgg 1680 tctgccagct aaaggtgaag atatattcct ccaattcagg acccacacga cgggaagaca 1740 agttcatgta ctttgagttc cctcagccgt tacctgtgtg tggtgatatc aaagtagagt 1800 tcttccacaa acagaacaag atgctaaaaa aggacaaaat gtttcacttt tgggtaaata 1860 cattcttcat accaggacca gaggaaacct cagaaaaagt agaaaatgga agtctatgtg 1920 atcaagaaat cgatagcatt tgcagtatag agcgtgcaga taatgacaag gaatatctag 1980 tacttacttt aacaaaaaat gatcttgaca aagcaaataa agacaaagcc aaccgatact 2040 tttctccaaa ttttaaggtg aagctgtact tcacaaaaac agtagaggag ccgtcaaatc 2100 cagaggctag cagttcaact tctgtaacac cagatgttag tgacaatgaa cctgatcatt 2160 atagatattc tgacaccact gactctgatc cagagaatga accttttgat gaagatcagc 2220 atacacaaat tacaaaagtc tgaatttttt tttatcaaga gggataaaac accatgaaaa 2280 taaacttgaa taaactgaaa atggaccttt ttttttttaa tggcaatagg acattgtgtc 2340 agattaccag ttataggaac aattctcttt tcctgaccaa tcttgtttta ccctatacat 2400 ccacagggtt ttgacacttg ttgtccagtt gaaaaaaggt tgtgtagctg tgtcatgtat 2460 ataccttttt gtgtcaaaag gacatttaaa attcaattag gattaataaa gatggcactt 2520 tcccgtttta ttccagtttt ataaaaagtg gagacagact gatgtgtata cgtaggaatt 2580 ttttcctttt gtgttctgtc accaactgaa gtggctaaag agctttgtga tatactggtt 2640 cacatcctac ccctttgcac ttgtggcaac agataagttt gcagttggct aagagaggtt 2700 tccgaagggt tttgctacat tctaatgcat gtattcgggt taggggaatg gagggaatgc 2760 tcagaaagga aataatttta tgctggactc tggaccatat accatctcca gctatttaca 2820 cacacctttc tttagcatgc tacagttatt aatctggaca ttcgaggaat tggccgctgt 2880 cactgcttgt tgtttgcgca ttttttttta aagcatattg gtgctagaaa aggcagctaa 2940 aggaagtgaa tctgtattgg ggtacaggaa tgaaccttct gcaacatctt aagatccaca 3000 aatgaaggga tataaaaata atgtcatagg taagaaacac agcaacaatg acttaaccat 3060 ataaatgtgg aggctatcaa caaagaatgg gcttgaaaca ttataaaaat tgacaatgat 3120 ttattaaata tgttttctca attgtaacga cttctccatc tcctgtgtaa tcaaggccag 3180 tgctaaaatt cagatgctgt tagtacctac atcagtcaac aacttacact tattttacta 3240 gttttcaatc ataatacctg ctgtggatgc ttcatgtgct gcctgcaagc ttcttttttc 3300 tcattaaata taaaatattt tgtaatgctg cacagaaatt ttcaatttga gattctacag 3360 taagcgtttt ttttctttga agatttatga tgcacttatt caatagctgt cagccgttcc 3420 acccttttga ccttacacat tctattacaa tgaattttgc agttttgcac attttttaaa 3480 tgtcattaac tgttagggaa ttttacttga atactgaata catataatgt ttatattaaa 3540 aaggacattt gtgttaaaaa ggaaattaga gttgcagtaa actttcaatg ctgcacacaa 3600 aaaaaagaca tttgattttt cagtagaaat tgtcctacat gtgctttatt gatttgctat 3660 tgaaagaata gggttttttt tttttttttt tttttttttt ttaaatgtgc agtgttgaat 3720 catttcttca tagtgctccc ccgagttggg actagggctt caatttcact tcttaaaaaa 3780 aatcatcata tatttgatat gcccagactg catacgattt taagcggagt acaactacta 3840 ttgtaaagct aatgtgaaga tattattaaa aaggtttttt tttccagaaa tttggtgtct 3900 tcaaattata ccttcacctt gacatttgaa tatccagcca ttttgtttct taatggtata 3960 aaattccatt ttcaataact tattggtgct gaaattgttc actagctgtg gtctgaccta 4020 gttaatttac aaatacagat tgaataggac ctactagagc agcatttata gagtttgatg 4080 gcaaatagat taggcagaac ttcatctaaa atattcttag taaataatgt tgacacgttt 4140 tccatacctt gtcagtttca ttcaacaatt tttaaatttt taacaaagct cttaggattt 4200 acacatttat atttaaacat tgatatatag agtattgatt gattgctcat aagttaaatt 4260 ggtaaagtta gagacaacta ttctaacacc tcaccattga aatttatatg ccaccttgtc 4320 tttcataaaa gctgaaaatt gttacctaaa atgaaaatca acttcatgtt ttgaagatag 4380 ttataaatat tgttctttgt tacaatttcg ggcaccgcat attaaaacgt aactttattg 4440 ttccaatatg taacatggag ggccaggtca taaataatga cattataatg ggcttttgca 4500 ctgttattat ttttcctttg gaatgtgaag gtctgaatga gggttttgat tttgaatgtt 4560 tcaatgtttt tgagaagcct tgcttacatt ttatggtgta gtcattggaa atggaaaaat 4620 ggcattatat atattatata tataaatata tattatacat actctcctta ctttatttca 4680 gttaccatcc ccatagaatt tgacaagaat tgctatgact gaaaggtttt cgagtcctaa 4740 ttaaaacttt atttatggca gtattcataa ttagcctgaa atgcattctg taggtaatct 4800 ctgagtttct ggaatatttt cttagacttt ttggatgtgc agcagcttac atgtctgaag 4860 ttacttgaag gcatcacttt taagaaagct tacagttggg ccctgtacca tcccaagtcc 4920 tttgtagctc ctcttgaaca tgtttgccat acttttaaaa gggtagttga ataaatagca 4980 tcaccattct ttgctgtggc acaggttata aacttaagtg gagtttaccg gcagcatcaa 5040 atgtttcagc tttaaaaaat aaaagtaggg tacaagttta atgtttagtt ctagaaattt 5100 tgtgcaatat gttcataacg atggctgtgg ttgccacaaa gtgcctcgtt tacctttaaa 5160 tactgttaat gtgtcatgca tgcagatgga aggggtggaa ctgtgcacta aagtgggggc 5220 tttaactgta gtatttggca gagttgcctt ctacctgcca gttcaaaagt tcaacctgtt 5280 ttcatataga atatatatac taaaaaattt cagtctgtta aacagcctta ctctgattca 5340 gcctcttcag atactcttgt gctgtgcagc agtggctctg tgtgtaaatg ctatgcactg 5400 aggatacaca aaaataccaa tatgatgtgt acaggataat gcctcatccc aatcagatgt 5460 ccatttgtta ttgtgtttgt taacaaccct ttatctctta gtgttataaa ctccacttaa 5520 aactgattaa agtctcattc ttgtcattgt gtgggtgttt tattaaatga gagtttataa 5580 ttcaaattgc ttaagtccat tgaagtttta attaatgggc agccaaatgt gaatacaaag 5640 ttttcagttt ttttttttcc tgctgtcctt caaagcctac tgtttaaaaa aaaaaaaaaa 5700 aaaaaacatg gcctgagagt agagtatctg tctactcatg tttaattaag gaaaaacact 5760 tatttttagg gctttagtca tcacttcata aattgtataa gcacattaaa tagcgttcta 5820 gtcctgaaaa agtccaagat tcttagaaaa ttgtgcatat ttttattatg acagatgttt 5880 gaagataatt ccccagaatg gatttgatac tttagatttc aattttgtgg cttttgtcta 5940 ttattctgta ctctgccatc agcatatgga aagcttcatt tactcatcat gacttgtgcc 6000 atataaaaat tgatatttcg gaatagtcta aaggactttt tgtacttgaa tttaatcatg 6060 ttgtttctaa tattcttaaa agcttgaaga ctaaagcata tcctttcaac aaagcatagt 6120 aaggtaataa gaaagtgtag tttgtacaag tgttaaaaaa ataaagtaga caatgttaca 6180 gtgggactta ttatttcaag tttacatttt ctccatgtaa ttttttaaaa agtaaatgaa 6240 aaaatgtgca ataatgtaaa atatgaagtg tatgtgtaca cacattttat ttttcggtat 6300 cttgggtata cgtatggttg aaaactatac tggagtctaa aagtattcta atttataaga 6360 agacattttg gtgatgtttg aaaaatagaa atgtgctagt tttgttttta tatcatgtcc 6420 tttgtacgtt gtaatatgag ctggcttggt tcagtaaatg ccatcaccat ttccattgag 6480 aatttaaaac tcaccagtgt ttaatatgca ggcttccaaa ggcttatgaa aaaaatcaag 6540 acccttaaat ctagttaatt tgctgctaac atgaaactct ttggttcttt tatttttgcc 6600 agataattag acacacatct aaagcttagt cttaaatggc ttaagtgtag ctattgatta 6660 gtgctgttgc tagttcagaa agaaatgttt gtgaatggaa acaagaatat tcagtccaaa 6720 ctgttgtaag gacagtacct gaaaaccagg aaacaggata atggaaaaag tcttttaaag 6780 atgaaatgtt ggagccaact ttcttataga attaattgta tgtggctata gaaagcctaa 6840 tgattgttgc ttatttttga gagcatatta ttcttttatg accataatct tgctgttttt 6900 ccatcttcca aaagatcttc cttctaatat gtatatcaga atgtgggtag ccagtcagac 6960 aaattcatat tggttggtag ctttaaaaag tttgtaatgt gaagacagga aaggacaaaa 7020 tagtttgctt tggtggtagt actctggttg ttaagctagg tattttgaga ctacttcccc 7080 atcacaacaa caataaaata atcactcata atcctatcac ctggagacat agccatcgtt 7140 aatatgttag tgactataca atcatgtttt cttctgtata tccatgtata ttctttaaaa 7200 atgaaattta tactgtacct gatctcaaag ctttttagct tagtatatct gtcatgaatt 7260 tgtaggatgt tccattgcat cagaaaacgg acagtgattt gattactttc taatgccaca 7320 gatgcagatt acatgtagtt attgagaatc ctttcgaatt cagtggctta atcatgaatg 7380 tctaaatatt gttgacatta ggatgataca tgtaaattaa agttacattt gtttagcata 7440 gacaagctta acattgtaga tgtttctctt caaaaatcat cttaaacatt tgcatttgga 7500 attgtgttaa atagaatgtg tgaaacactg tattagtaaa cttcatcacc tttctacttc 7560 cttatagttt gaacttttca gtttttgtag ttcccaaaca gttgctcaat ttagagcaaa 7620 ttaatttaac acctgccaaa aaaaggctgc tgttggctta tcagttgtct ttaaattcaa 7680 atgctcatgt gacttttatc acatcaaaaa atatttcatt aatgattcac ctttagctct 7740 gaaaattacc gcgtttagta attatagtgg gcttataaaa acatgcaact ctttttgata 7800 gttatttgag aattttggtg aaaaatattt agctgagggc agtatagaac ttataaacca 7860 atatattgat atttttaaaa catttttaca tataagtaaa ctgccatctt tgagcataac 7920 tacatttaaa aataaagctg catattttta aatcaagtgt ttaacaagaa tttatatttt 7980 ttatttttta aaattaaaaa taatttatat ttcctctgtt gcatgaggat tctcatctgt 8040 gcttataatg gttagagatt ttatttgtgt ggaatgaagt gaggcttgta gtcatggttc 8100 tagtgtttca gtttgccaag tctgtttact gcagtgaaat tcatcaaatg tttcagtgtg 8160 gttttctgta gcctatcatt tactggctat ttttttatgt acacctttag gattttctgc 8220 ctactctatc cagttgtcca aatgatatcc tacattttac aaatgccctt tcagtttcta 8280 ttttcttttt ccattaaatt gccctcatgt cctaatgtgc agtttgtaag tgtgtgtgtg 8340 tgtgtctgtg tgtgtgtgaa tttgattttc aagagtgcta gacttccaat ttgagagatt 8400 aaataattta attcaggcaa acatttttca ttggaatttc acagttcatt gtaatgaaaa 8460 tgttaatcct ggatgacctt tgacatacag taatgaatct tggatattaa tgaatttgtt 8520 agtagcatct tgatgtgtgt tttaatgagt tattttcaaa gttgtgcatt aaaccaaagt 8580 tggcatactg gaagtgttta tatcaagttc catttggcta ctgatggaca aaaaatagaa 8640 atgccttcct atggagagta tttttccttt aaaaaattaa aaaggttaat tattttgact 8700 aaaaaaaaaa aaaaaaaaaa 8718 <210> 254 <211> 4510 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4510) <223> PTGS2 mRNA <400> 254 aattgtcata cgacttgcag tgagcgtcag gagcacgtcc aggaactcct cagcagcgcc 60 tccttcagct ccacagccag acgccctcag acagcaaagc ctacccccgc gccgcgccct 120 gcccgccgct gcgatgctcg cccgcgccct gctgctgtgc gcggtcctgg cgctcagcca 180 tacagcaaat ccttgctgtt cccacccatg tcaaaaccga ggtgtatgta tgagtgtggg 240 atttgaccag tataagtgcg attgtacccg gacaggattc tatggagaaa actgctcaac 300 accggaattt ttgacaagaa taaaattatt tctgaaaccc actccaaaca cagtgcacta 360 catacttacc cacttcaagg gattttggaa cgttgtgaat aacattccct tccttcgaaa 420 tgcaattatg agttatgtgt tgacatccag atcacatttg attgacagtc caccaactta 480 caatgctgac tatggctaca aaagctggga agccttctct aacctctcct attatactag 540 agcccttcct cctgtgcctg atgattgccc gactcccttg ggtgtcaaag gtaaaaagca 600 gcttcctgat tcaaatgaga ttgtggaaaa attgcttcta agaagaaagt tcatccctga 660 tccccagggc tcaaacatga tgtttgcatt ctttgcccag cacttcacgc atcagttttt 720 caagacagat cataagcgag ggccagcttt caccaacggg ctgggccatg gggtggactt 780 aaatcatatt tacggtgaaa ctctggctag acagcgtaaa ctgcgccttt tcaaggatgg 840 aaaaatgaaa tatcagataa ttgatggaga gatgtatcct cccacagtca aagatactca 900 ggcagagatg atctaccctc ctcaagtccc tgagcatcta cggtttgctg tggggcagga 960 ggtctttggt ctggtgcctg gtctgatgat gtatgccaca atctggctgc gggaacacaa 1020 cagagtatgc gatgtgctta aacaggagca tcctgaatgg ggtgatgagc agttgttcca 1080 gacaagcagg ctaatactga taggagagac tattaagatt gtgattgaag attatgtgca 1140 acacttgagt ggctatcact tcaaactgaa atttgaccca gaactacttt tcaacaaaca 1200 attccagtac caaaatcgta ttgctgctga atttaacacc ctctatcact ggcatcccct 1260 tctgcctgac acctttcaaa ttcatgacca gaaatacaac tatcaacagt ttatctacaa 1320 caactctata ttgctggaac atggaattac ccagtttgtt gaatcattca ccaggcaaat 1380 tgctggcagg gttgctggtg gtaggaatgt tccacccgca gtacagaaag tatcacaggc 1440 ttccattgac cagagcaggc agatgaaata ccagtctttt aatgagtacc gcaaacgctt 1500 tatgctgaag ccctatgaat catttgaaga acttacagga gaaaaggaaa tgtctgcaga 1560 gttggaagca ctctatggtg acatcgatgc tgtggagctg tatcctgccc ttctggtaga 1620 aaagcctcgg ccagatgcca tctttggtga aaccatggta gaagttggag caccattctc 1680 cttgaaagga cttatgggta atgttatatg ttctcctgcc tactggaagc caagcacttt 1740 tggtggagaa gtgggttttc aaatcatcaa cactgcctca attcagtctc tcatctgcaa 1800 taacgtgaag ggctgtccct ttacttcatt cagtgttcca gatccagagc tcattaaaac 1860 agtcaccatc aatgcaagtt cttcccgctc cggactagat gatatcaatc ccacagtact 1920 actaaaagaa cgttcgactg aactgtagaa gtctaatgat catatttatt tatttatatg 1980 aaccatgtct attaatttaa ttatttaata atatttatat taaactcctt atgttactta 2040 acatcttctg taacagaagt cagtactcct gttgcggaga aaggagtcat acttgtgaag 2100 acttttatgt cactactcta aagattttgc tgttgctgtt aagtttggaa aacagttttt 2160 attctgtttt ataaaccaga gagaaatgag ttttgacgtc tttttacttg aatttcaact 2220 tatattataa gaacgaaagt aaagatgttt gaatacttaa acactgtcac aagatggcaa 2280 aatgctgaaa gtttttacac tgtcgatgtt tccaatgcat cttccatgat gcattagaag 2340 taactaatgt ttgaaatttt aaagtacttt tggttatttt tctgtcatca aacaaaaaca 2400 ggtatcagtg cattattaaa tgaatattta aattagacat taccagtaat ttcatgtcta 2460 ctttttaaaa tcagcaatga aacaataatt tgaaatttct aaattcatag ggtagaatca 2520 cctgtaaaag cttgtttgat ttcttaaagt tattaaactt gtacatatac caaaaagaag 2580 ctgtcttgga tttaaatctg taaaatcagt agaaatttta ctacaattgc ttgttaaaat 2640 attttataag tgatgttcct ttttcaccaa gagtataaac ctttttagtg tgactgttaa 2700 aacttccttt taaatcaaaa tgccaaattt attaaggtgg tggagccact gcagtgttat 2760 cttaaaataa gaatattttg ttgagatatt ccagaatttg tttatatggc tggtaacatg 2820 taaaatctat atcagcaaaa gggtctacct ttaaaataag caataacaaa gaagaaaacc 2880 aaattattgt tcaaatttag gtttaaactt ttgaagcaaa ctttttttta tccttgtgca 2940 ctgcaggcct ggtactcaga ttttgctatg aggttaatga agtaccaagc tgtgcttgaa 3000 taatgatatg ttttctcaga ttttctgttg tacagtttaa tttagcagtc catatcacat 3060 tgcaaaagta gcaatgacct cataaaatac ctcttcaaaa tgcttaaatt catttcacac 3120 attaatttta tctcagtctt gaagccaatt cagtaggtgc attggaatca agcctggcta 3180 cctgcatgct gttccttttc ttttcttctt ttagccattt tgctaagaga cacagtcttc 3240 tcatcacttc gtttctccta ttttgtttta ctagttttaa gatcagagtt cactttcttt 3300 ggactctgcc tatattttct tacctgaact tttgcaagtt ttcaggtaaa cctcagctca 3360 ggactgctat ttagctcctc ttaagaagat taaaagagaa aaaaaaaggc ccttttaaaa 3420 atagtataca cttattttaa gtgaaaagca gagaatttta tttatagcta attttagcta 3480 tctgtaacca agatggatgc aaagaggcta gtgcctcaga gagaactgta cggggtttgt 3540 gactggaaaa agttacgttc ccattctaat taatgccctt tcttatttaa aaacaaaacc 3600 aaatgatatc taagtagttc tcagcaataa taataatgac gataatactt cttttccaca 3660 tctcattgtc actgacattt aatggtactg tatattactt aatttattga agattattat 3720 ttatgtctta ttaggacact atggttataa actgtgttta agcctacaat cattgatttt 3780 tttttgttat gtcacaatca gtatattttc tttggggtta cctctctgaa tattatgtaa 3840 acaatccaaa gaaatgattg tattaagatt tgtgaataaa tttttagaaa tctgattggc 3900 atattgagat atttaaggtt gaatgtttgt ccttaggata ggcctatgtg ctagcccaca 3960 aagaatattg tctcattagc ctgaatgtgc cataagactg accttttaaa atgttttgag 4020 ggatctgtgg atgcttcgtt aatttgttca gccacaattt attgagaaaa tattctgtgt 4080 caagcactgt gggttttaat atttttaaat caaacgctga ttacagataa tagtatttat 4140 ataaataatt gaaaaaaatt ttcttttggg aagagggaga aaatgaaata aatatcatta 4200 aagataactc aggagaatct tctttacaat tttacgttta gaatgtttaa ggttaagaaa 4260 gaaatagtca atatgcttgt ataaaacact gttcactgtt ttttttaaaa aaaaaacttg 4320 atttgttatt aacattgatc tgctgacaaa acctgggaat ttgggttgtg tatgcgaatg 4380 tttcagtgcc tcagacaaat gtgtatttaa cttatgtaaa agataagtct ggaaataaat 4440 gtctgtttat ttttgtacta tttaaaaatt gacagatctt ttctgaagat aaactttgat 4500 tgtttctata 4510 <210> 255 <211> 1884 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1884) <223> PTX3 mRNA <400> 255 actctcactc tcctccgctc aaactcagct cacttgagag tctcctcccg ccagctgtgg 60 aaagaacttt gcgtctctcc agcaatgcat ctccttgcga ttctgttttg tgctctctgg 120 tctgcagtgt tggccgagaa ctcggatgat tatgatctca tgtatgtgaa tttggacaac 180 gaaatagaca atggactcca tcccactgag gaccccacgc cgtgcgcctg cggtcaggag 240 cactcggaat gggacaagct cttcatcatg ctggagaact cgcagatgag agagcgcatg 300 ctgctgcaag ccacggacga cgtcctgcgg ggcgagctgc agaggctgcg ggaggagctg 360 ggccggctcg cggaaagcct ggcgaggccg tgcgcgccgg gggctcccgc agaggccagg 420 ctgaccagtg ctctggacga gctgctgcag gcgacccgcg acgcgggccg caggctggcg 480 cgtatggagg gcgcggaggc gcagcgccca gaggaggcgg ggcgcgccct ggccgcggtg 540 ctagaggagc tgcggcagac gcgagccgac ctgcacgcgg tgcagggctg ggctgcccgg 600 agctggctgc cggcaggttg tgaaacagct attttattcc caatgcgttc caagaagatt 660 tttggaagcg tgcatccagt gagaccaatg aggcttgagt cttttagtgc ctgcatttgg 720 gtcaaagcca cagatgtatt aaacaaaacc atcctgtttt cctatggcac aaagaggaat 780 ccatatgaaa tccagctgta tctcagctac caatccatag tgtttgtggt gggtggagag 840 gagaacaaac tggttgctga agccatggtt tccctgggaa ggtggaccca cctgtgcggc 900 acctggaatt cagaggaagg gctcacatcc ttgtgggtaa atggtgaact ggcggctacc 960 actgttgaga tggccacagg tcacattgtt cctgagggag gaatcctgca gattggccaa 1020 gaaaagaatg gctgctgtgt gggtggtggc tttgatgaaa cattagcctt ctctgggaga 1080 ctcacaggct tcaatatctg ggatagtgtt cttagcaatg aagagataag agagaccgga 1140 ggagcagagt cttgtcacat ccgggggaat attgttgggt ggggagtcac agagatccag 1200 ccacatggag gagctcagta tgtttcataa atgttgtgaa actccacttg aagccaaaga 1260 aagaaactca cacttaaaac acatgccagt tgggaaggtc tgaaaactca gtgcataata 1320 ggaacacttg agactaatga aagagagagt tgagaccaat ctttatttgt actggccaaa 1380 tactgaataa acagttgaag gaaagacatt ggaaaaagct tttgaggata atgttactag 1440 actttatgcc atggtgcttt cagtttaatg ctgtgtctct gtcagataaa ctctcaaata 1500 attaaaaagg actgtattgt tgaacagagg gacaattgtt ttacttttct ttggttaatt 1560 ttgttttggc cagagatgaa ttttacattg gaagaataac aaaataagat ttgttgtcca 1620 ttgttcattg ttattggtat gtaccttatt acaaaaaaaa gatgaaaaca tatttatact 1680 acaaggtgac ttaacaacta taaatgtagt ttatgtgtta taatcgaatg tcacgttttt 1740 gagaagatag tcatataagt tatattgcaa aagggatttg tattaattta agactatttt 1800 tgtaaagctc tactgtaaat aaaatatttt ataaaactag ctcacgtcat ttaattataa 1860 atttaagaga tgttttggag caaa 1884 <210> 256 <211> 2398 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2398) <223> RAC1 mRNA <400> 256 gggaggccgg atgtgagtgg agcggccatt tcctgtttct ctgcagtttt cctcagcttt 60 gggtggtggc cgctgccggg catcggcttc cagtccgcgg agggcgaggc ggcgtggaca 120 gcggccccgg cacccagcgc cccgccgccc gcaagccgcg cgcccgtccg ccgcgccccg 180 agcccgccgc ttcctatctc agcgccctgc cgccgccgcc gcggcccagc gagcggccct 240 gatgcaggcc atcaagtgtg tggtggtggg agacggagct gtaggtaaaa cttgcctact 300 gatcagttac acaaccaatg catttcctgg agaatatatc cctactgtct ttgacaatta 360 ttctgccaat gttatggtag atggaaaacc ggtgaatctg ggcttatggg atacagctgg 420 acaagaagat tatgacagat tacgccccct atcctatccg caaacagttg gagaaacgta 480 cggtaaggat ataacctccc ggggcaaaga caagccgatt gccgatgtgt tcttaatttg 540 cttttccctt gtgagtcctg catcatttga aaatgtccgt gcaaagtggt atcctgaggt 600 gcggcaccac tgtcccaaca ctcccatcat cctagtggga actaaacttg atcttaggga 660 tgataaagac acgatcgaga aactgaagga gaagaagctg actcccatca cctatccgca 720 gggtctagcc atggctaagg agattggtgc tgtaaaatac ctggagtgct cggcgctcac 780 acagcgaggc ctcaagacag tgtttgacga agcgatccga gcagtcctct gcccgcctcc 840 cgtgaagaag aggaagagaa aatgcctgct gttgtaaatg tctcagcccc tcgttcttgg 900 tcctgtccct tggaaccttt gtacgctttg ctcaaaaaaa aacaaaaaaa aaaaacaaaa 960 aaaaaaaaca acggtggagc cttcgcactc aatgccaact ttttgttaca gattaatttt 1020 tccataaaac cattttttga accaatcagt aattttaagg ttttgtttgt tctaaatgta 1080 agagttcaga ctcacattct attaaaattt agccctaaaa tgacaagcct tcttaaagcc 1140 ttatttttca aaagcgcccc ccccattctt gttcagatta agagttgcca aaataccttc 1200 tgaactacac tgcattgttg tgccgagaac accgagcact gaactttgca aagaccttcg 1260 tctttgagaa gacggtagct tctgcagtta ggaggtgcag acacttgctc tcctatgtag 1320 ttctcagatg cgtaaagcag aacagcctcc cgaatgaagc gttgccattg aactcaccag 1380 tgagttagca gcacgtgttc ccgacataac attgtactgt aatggagtga gcgtagcagc 1440 tcagctcttt ggatcagtct ttgtgatttc atagcgagtt ttctgaccag cttttgcgga 1500 gattttgaac agaactgcta tttcctctaa tgaagaattc tgtttagctg tgggtgtgcc 1560 gggtggggtg tgtgtgatca aaggacaaag acagtatttt gacaaaatac gaagtggaga 1620 tttacactac attgtacaag gaatgaaagt gtcacgggta aaaactctaa aaggttaatt 1680 tctgtcaaat gcagtagatg atgaaagaaa ggttggtatt atcaggaaat gttttcttaa 1740 gcttttcctt tctcttacac ctgccatgcc tccccaaatt gggcatttaa ttcatcttta 1800 aactggttgt tctgttagtc gctaacttag taagtgcttt tcttatagaa ccccttctga 1860 ctgagcaata tgcctccttg tattataaaa tctttctgat aatgcattag aaggtttttt 1920 tgtcgattag taaaagtgct ttccatgtta ctttattcag agctaataag tgctttcctt 1980 agttttctag taactaggtg taaaaatcat gtgttgcagc tttatagttt ttaaaatatt 2040 ttagataatt cttaaactat gaaccttctt aacatcactg tcttgccaga ttaccgacac 2100 tgtcacttga ccaatactga ccctctttac ctcgcccacg cggacacacg cctcctgtag 2160 tcgctttgcc tattgatgtt cctttgggtc tgtgaggttc tgtaaactgt gctagtgctg 2220 acgatgttct gtacaactta actcactggc gagaatacag cgtgggaccc ttcagccact 2280 acaacagaat tttttaaatt gacagttgca gaattgtgga gtgtttttac attgatcttt 2340 tgctaatgca attagcatta tgttttgcat gtatgactta ataaatcctt gaatcata 2398 <210> 257 <211> 1943 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1943) <223> RHOA mRNA <400> 257 aatagtggat gagctgtgag tgcgcgcgcg tgcgcggggc cgcgacctgt gccggctcga 60 gcccgctggg cactcggagg cgcgcacgtc gttccccgcc ctcccgccgc cgcccgccct 120 cgctctctcg cgctaccctc ccgccgcccg cggtcctccg tcggttctct cgttagtcca 180 cggtctggtc ttcagctacc cgccttcgtc tccgagtttg cgactcgcgg accggcgtcc 240 ccggcgcgaa gaggctggac tcggattcgt tgcctgagca atggctgcca tccggaagaa 300 actggtgatt gttggtgatg gagcctgtgg aaagacatgc ttgctcatag tcttcagcaa 360 ggaccagttc ccagaggtgt atgtgcccac agtgtttgag aactatgtgg cagatatcga 420 ggtggatgga aagcaggtag agttggcttt gtgggacaca gctgggcagg aagattatga 480 tcgcctgagg cccctctcct acccagatac cgatgttata ctgatgtgtt tttccatcga 540 cagccctgat agtttagaaa acatcccaga aaagtggacc ccagaagtca agcatttctg 600 tcccaacgtg cccatcatcc tggttgggaa taagaaggat cttcggaatg atgagcacac 660 aaggcgggag ctagccaaga tgaagcagga gccggtgaaa cctgaagaag gcagagatat 720 ggcaaacagg attggcgctt ttgggtacat ggagtgttca gcaaagacca aagatggagt 780 gagagaggtt tttgaaatgg ctacgagagc tgctctgcaa gctagacgtg ggaagaaaaa 840 atctgggtgc cttgtcttgt gaaaccttgc tgcaagcaca gcccttatgc ggttaatttt 900 gaagtgctgt ttattaatct tagtgtatga ttactggcct ttttcattta tctataattt 960 acctaagatt acaaatcaga agtcatcttg ctaccagtat ttagaagcca actatgatta 1020 ttaacgatgt ccaacccgtc tggcccacca gggtcctttt gacactgctc taacagccct 1080 cctctgcact cccacctgac acaccaggcg ctaattcaag gaatttctta acttcttgct 1140 tctttctaga aagagaaaca gttggtaact tttgtgaatt aggctgtaac tactttataa 1200 ctaacatgtc ctgcctatta tctgtcagct gcaaggtact ctggtgagtc accacttcag 1260 ggctttactc cgtaacagat tttgttggca tagctctggg gtgggcagtt ttttgaaaat 1320 gggctcaacc agaaaagccc aagttcatgc agctgtggca gagttacagt tctgtggttt 1380 catgttagtt accttatagt tactgtgtaa ttagtgccac ttaatgtatg ttaccaaaaa 1440 taaatatatc taccccagac tagatgtagt attttttgta taattggatt tcctaatact 1500 gtcatcctca aagaaagtgt attggttttt taaaaaagaa agtgtatttg gaaataaagt 1560 cagatggaaa attcattttt taaattcccg ttttgtcact ttttctgata aaagatggcc 1620 atattacccc ttttcggccc catgtatctc agtaccccat ggagctgggc taagtaaata 1680 ggaattggtt tcacgcctga ggcaattaga cactttggaa gatggcataa cctgtctcac 1740 ctggacttaa gcatctggct ctaattcaca gtgctctttt ctcctcactg tatccaggtt 1800 ccctcccaga ggagccacca gttctcatgg gtggcactca gtctctcttc tctccagctg 1860 actaaacttt ttttctgtac cagttaattt ttccaactac taatagaata aaggcagttt 1920 tctaaacttc ctgtaaaaaa aaa 1943 <210> 258 <211> 3207 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3207) <223> SERPINB2 mRNA <400> 258 ggcccacaga ggagcacagc tgtgtttggc tgcagggcca agagcgctgt caagaagacc 60 cacacgcccc cctccagcag ctgaattcct gcagctcagc agccgccgcc agagcaggac 120 gaaccgccaa tcgcaaggca cctctgagaa cttcaggatg cagatgtctc cagccctcac 180 ctgcctagtc ctgggcctgg cccttgtctt tggtgaaggg tctgctgtgc accatccccc 240 atcctacgtg gcccacctgg cctcagactt cggggtgagg gtgtttcagc aggtggcgca 300 ggcctccaag gaccgcaacg tggttttctc accctatggg gtggcctcgg tgttggccat 360 gctccagctg acaacaggag gagaaaccca gcagcagatt caagcagcta tgggattcaa 420 gattgatgac aagggcatgg cccccgccct ccggcatctg tacaaggagc tcatggggcc 480 atggaacaag gatgagatca gcaccacaga cgcgatcttc gtccagcggg atctgaagct 540 ggtccagggc ttcatgcccc acttcttcag gctgttccgg agcacggtca agcaagtgga 600 cttttcagag gtggagagag ccagattcat catcaatgac tgggtgaaga cacacacaaa 660 aggtatgatc agcaacttgc ttgggaaagg agccgtggac cagctgacac ggctggtgct 720 ggtgaatgcc ctctacttca acggccagtg gaagactccc ttccccgact ccagcaccca 780 ccgccgcctc ttccacaaat cagacggcag cactgtctct gtgcccatga tggctcagac 840 caacaagttc aactatactg agttcaccac gcccgatggc cattactacg acatcctgga 900 actgccctac cacggggaca ccctcagcat gttcattgct gccccttatg aaaaagaggt 960 gcctctctct gccctcacca acattctgag tgcccagctc atcagccact ggaaaggcaa 1020 catgaccagg ctgccccgcc tcctggttct gcccaagttc tccctggaga ctgaagtcga 1080 cctcaggaag cccctagaga acctgggaat gaccgacatg ttcagacagt ttcaggctga 1140 cttcacgagt ctttcagacc aagagcctct ccacgtcgcg caggcgctgc agaaagtgaa 1200 gatcgaggtg aacgagagtg gcacggtggc ctcctcatcc acagctgtca tagtctcagc 1260 ccgcatggcc cccgaggaga tcatcatgga cagacccttc ctctttgtgg tccggcacaa 1320 ccccacagga acagtccttt tcatgggcca agtgatggaa ccctgaccct ggggaaagac 1380 gccttcatct gggacaaaac tggagatgca tcgggaaaga agaaactccg aagaaaagaa 1440 ttttagtgtt aatgactctt tctgaaggaa gagaagacat ttgccttttg ttaaaagatg 1500 gtaaaccaga tctgtctcca agaccttggc ctctccttgg aggaccttta ggtcaaactc 1560 cctagtctcc acctgagacc ctgggagaga agtttgaagc acaactccct taaggtctcc 1620 aaaccagacg gtgacgcctg cgggaccatc tggggcacct gcttccaccc gtctctctgc 1680 ccactcgggt ctgcagacct ggttcccact gaggcccttt gcaggatgga actacggggc 1740 ttacaggagc ttttgtgtgc ctggtagaaa ctatttctgt tccagtcaca ttgccatcac 1800 tcttgtactg cctgccaccg cggaggaggc tggtgacagg ccaaaggcca gtggaagaaa 1860 caccctttca tctcagagtc cactgtggca ctggccaccc ctccccagta caggggtgct 1920 gcaggtggca gagtgaatgt cccccatcat gtggcccaac tctcctggcc tggccatctc 1980 cctccccaga aacagtgtgc atgggttatt ttggagtgta ggtgacttgt ttactcattg 2040 aagcagattt ctgcttcctt ttatttttat aggaatagag gaagaaatgt cagatgcgtg 2100 cccagctctt caccccccaa tctcttggtg gggaggggtg tacctaaata tttatcatat 2160 ccttgccctt gagtgcttgt tagagagaaa gagaactact aaggaaaata atattattta 2220 aactcgctcc tagtgtttct ttgtggtctg tgtcaccgta tctcaggaag tccagccact 2280 tgactggcac acacccctcc ggacatccag cgtgacggag cccacactgc caccttgtgg 2340 ccgcctgaga ccctcgcgcc ccccgcgccc ctctttttcc ccttgatgga aattgaccat 2400 acaatttcat cctccttcag gggatcaaaa ggacggagtg gggggacaga gactcagatg 2460 aggacagagt ggtttccaat gtgttcaata gatttaggag cagaaatgca aggggctgca 2520 tgacctacca ggacagaact ttccccaatt acagggtgac tcacagccgc attggtgact 2580 cacttcaatg tgtcatttcc ggctgctgtg tgtgagcagt ggacacgtga ggggggggtg 2640 ggtgagagag acaggcagct cggattcaac taccttagat aatatttctg aaaacctacc 2700 agccagaggg tagggcacaa agatggatgt aatgcacttt gggaggccaa ggcgggagga 2760 ttgcttgagc ccaggagttc aagaccagcc tgggcaacat accaagaccc ccgtctcttt 2820 aaaaatatat atattttaaa tatacttaaa tatatatttc taatatcttt aaatatatat 2880 atatatttta aagaccaatt tatgggagaa ttgcacacag atgtgaaatg aatgtaatct 2940 aatagaagcc taatcagccc accatgttct ccactgaaaa atcctctttc tttggggttt 3000 ttctttcttt cttttttgat tttgcactgg acggtgacgt cagccatgta caggatccac 3060 aggggtggtg tcaaatgcta ttgaaattgt gttgaattgt atgctttttc acttttgata 3120 aataaacatg taaaaatgtt tcaaaaaaat aataaaataa ataaatacga agaatatgtc 3180 aggacagtca aaaaaaaaaa aaaaaaa 3207 <210> 259 <211> 2180 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2180) <223> SERPINE1 mRNA <400> 259 gtaacaactc tcagaggagc attgcccgtc agacagcaac tcagagaata accagagaac 60 aaccagcatt tcttgcacta caacttgctt aagctcttac acttcatagt gaagctatgc 120 accaccgagt gaagcgatgt ggaacattgg aaagagtggg cttccttaga cagacctggg 180 cttgaatccc tgctccacta cctaccagct gtgtgacctt atacaagtta cttaatgttt 240 ctgagcatca ggatataatc tataaaatag ggagaatcac ctctacctca tacagattct 300 gcaaagatta aacgaggaga ggagattgaa acaatggagg atctttgtgt ggcaaacaca 360 ctctttgccc tcaatttatt caagcatctg gcaaaagcaa gccccaccca gaacctcttc 420 ctctccccat ggagcatctc gtccaccatg gccatggtct acatgggctc caggggcagc 480 accgaagacc agatggccaa ggtgcttcag tttaatgaag tgggagccaa tgcagttacc 540 cccatgactc cagagaactt taccagctgt gggttcatgc agcagatcca gaagggtagt 600 tatcctgatg cgattttgca ggcacaagct gcagataaaa tccattcatc cttccgctct 660 ctcagctctg caatcaatgc atccacaggg aattatttac tggaaagtgt caataagctg 720 tttggtgaga agtctgcgag cttccgggaa gaatatattc gactctgtca gaaatattac 780 tcctcagaac cccaggcagt agacttccta gaatgtgcag aagaagctag aaaaaagatt 840 aattcctggg tcaagactca aaccaaaggc aaaatcccaa acttgttacc tgaaggttct 900 gtagatgggg ataccaggat ggtcctggtg aatgctgtct acttcaaagg aaagtggaaa 960 actccatttg agaagaaact aaatgggctt tatcctttcc gtgtaaactc ggctcagcgc 1020 acacctgtac agatgatgta cttgcgtgaa aagctaaaca ttggatacat agaagaccta 1080 aaggctcaga ttctagaact cccatatgct ggagatgtta gcatgttctt gttgcttcca 1140 gatgaaattg ccgatgtgtc cactggcttg gagctgctgg aaagtgaaat aacctatgac 1200 aaactcaaca agtggaccag caaagacaaa atggctgaag atgaagttga ggtatacata 1260 ccccagttca aattagaaga gcattatgaa ctcagatcca ttctgagaag catgggcatg 1320 gaggacgcct tcaacaaggg acgggccaat ttctcaggga tgtcggagag gaatgacctg 1380 tttctttctg aagtgttcca ccaagccatg gtggatgtga atgaggaggg cactgaagca 1440 gccgctggca caggaggtgt tatgacaggg agaactggac atggaggccc acagtttgtg 1500 gcagatcatc cttttctttt tcttattatg cataagataa ccaactgcat tttatttttc 1560 ggcagatttt cctcacccta aaactaagcg tgctgcttct gcaaaagatt tttgtagatg 1620 agctgtgtgc ctcagaattg ctatttcaaa ttgccaaaaa tttagagatg ttttctacat 1680 atttctgctc ttctgaacaa cttctgctac ccactaaata aaaacacaga aataattaga 1740 caattgtcta ttataacatg acaaccctat taatcatttg gtcttctaaa atgggatcat 1800 gcccatttag attttcctta ctatcagttt atttttataa cattaacttt tactttgtta 1860 tttattattt tatataatgg tgagttttta aattattgct cactgcctat ttaatgtagc 1920 taataaagtt atagaagcag atgatctgtt aatttcctat ctaataaatg cctttaattg 1980 ttctcataat gaagaataag taggtatccc tccatgccct tctgtaataa atatctggaa 2040 aaaacattaa acaataggca aatatatgtt atgtgcattt ctagaaatac ataacacata 2100 tatatgtctg tatcttatat tcaattgcaa gtatataata aataaacctg cttccaaaca 2160 acaataaaaa aaaaaaaaaa 2180 <210> 260 <211> 2259 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2259) <223> SERPINE2 mRNA <400> 260 cgataaagcc cccgccgccg cggcagccag cttgcgctgt ggggctgccc gggctgcgcg 60 gcgtctgcag gcgccaccgc tgcctctttc cggctgtgac cctcctcgcc gccgccgctt 120 ggctgcgtcc tccgactccc cgcgccgccg agaccaggct cccgctccgg ttgcggccgc 180 accgccctcc gcggccgccc cctggggatc cagcgagcgc ggtcgtcctt ggtggaagga 240 accatgaact ggcatctccc cctcttcctc ttggcctctg tgacgctgcc ttccatctgc 300 tcccacttca atcctctgtc tctcgaggaa ctaggctcca acacggggat ccaggttttc 360 aatcagattg tgaagtcgag gcctcatgac aacatcgtga tctctcccca tgggattgcg 420 tcggtcctgg ggatgcttca gctgggggcg gacggcagga ccaagaagca gctcgccatg 480 gtgatgagat acggcgtaaa tggagttggt aaaatattaa agaagatcaa caaggccatc 540 gtctccaaga agaataaaga cattgtgaca gtggctaacg ccgtgtttgt taagaatgcc 600 tctgaaattg aagtgccttt tgttacaagg aacaaagatg tgttccagtg tgaggtccgg 660 aatgtgaact ttgaggatcc agcctctgcc tgtgattcca tcaatgcatg ggttaaaaat 720 gaaaccaggg atatgattga caatctgctg tccccagatc ttattgatgg tgtgctcacc 780 agactggtcc tcgtcaacgc agtgtatttc aagggtctgt ggaaatcacg gttccaaccc 840 gagaacacaa agaaacgcac tttcgtggca gccgacggga aatcctatca agtgccaatg 900 ctggcccagc tctccgtgtt ccggtgtggg tcgacaagtg cccccaatga tttatggtac 960 aacttcattg aactgcccta ccacggggaa agcatcagca tgctgattgc actgccgact 1020 gagagctcca ctccgctgtc tgccatcatc ccacacatca gcaccaagac catagacagc 1080 tggatgagca tcatggtgcc caagagggtg caggtgatcc tgcccaagtt cacagctgta 1140 gcacaaacag atttgaagga gccgctgaaa gttcttggca ttactgacat gtttgattca 1200 tcaaaggcaa attttgcaaa aataacaaca gggtcagaaa acctccatgt ttctcatatc 1260 ttgcaaaaag caaaaattga agtcagtgaa gatggaacca aagcttcagc agcaacaact 1320 gcaattctca ttgcaagatc atcgcctccc tggtttatag tagacagacc ttttctgttt 1380 ttcatccgac ataatcctac aggtgctgtg ttattcatgg ggcagataaa caaaccctga 1440 agagtataca aaagaaacca tgcaaagcaa cgactacttt gctacgaaga aagactcctt 1500 tcctgcatct ttcatagttc tgttaaatat ttttgtacat cgcttctttt tcaaaactag 1560 ttcttaggaa cagactcgat gcaagtgttt ctgttctggg aggtattgga gggaaaaaac 1620 aagcaggatg gctggaacac tgtactgagg aatgaataga aaggcttcca gatgtctaaa 1680 agattcttta aactactgaa ctgttaccta ggttaacaac cctgttgagt atttgctgtt 1740 tgtccagttc aggaattttt gttttgtttt gtctatatgt gcggcttttc agaagaaatt 1800 taatcagtgt gacagaaaaa aaaatgtttt atggtagctt ttacttttta tgaaaaaaaa 1860 attatttgcc ttttaaattc ttttccccca tccccctcca aagtcttgat agcaagcgtt 1920 attttggggg tagaaacggt gaaatctcta gcctctttgt gtttttgttg ttgttgttgt 1980 tgttgtttta tataatgcat gtattcacta aaataaaatt taaaaaactc ctgtcttgct 2040 agacaaggtt gctgttgtgc agtgtgcctg tcactactgg tctgtactcc ttggatttgc 2100 atttttgtat tttgtacaaa gtaaaaataa actgttatga gtagtaaaaa taaagctatt 2160 tctctgctat ttgaaaatac aatagaagaa actgagcctt ttagacattc gtcagcctct 2220 tctaataaac ctttgtacta tgtaaacatc aggaaattc 2259 <210> 261 <211> 3297 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3297) <223> SLC20A1 mRNA <400> 261 ggagtgatgg ctgccggcgc tctctgcgtg gttcttcttc tcggccgctg aaacccccgc 60 ggctgcttcc tgggaaggtc gtgagtcccg ctgagctgtc cccggtgccg ccgacccggg 120 ccgtgtgccc gtggctccag ccgctgtcgc ctcgatctcc tcgtctcccg ctccgccctc 180 ccttttccct ggatgaactt gcgtcctttc tcttctccgc catggaattc tgctccgtgc 240 ttttagccct cctgagccaa agaaacccca gacaacagat gcccatacgc agcgtatagc 300 agtaactccc cagctcggtt tctgtgccgt agtttacagt atttaatttt atataatata 360 tattatttat tatagcattt ttgatacctc atattctgtt tacacatctt gaaaggcgct 420 cagtagttct cttactaaac aaccactact ccagagaatg gcaacgctga ttaccagtac 480 tacagctgct accgccgctt ctggtccttt ggtggactac ctatggatgc tcatcctggg 540 cttcattatt gcatttgtct tggcattctc cgtgggagcc aatgatgtag caaattcttt 600 tggtacagct gtgggctcag gtgtagtgac cctgaagcaa gcctgcatcc tagctagcat 660 ctttgaaaca gtgggctctg tcttactggg ggccaaagtg agcgaaacca tccggaaggg 720 cttgattgac gtggagatgt acaactcgac tcaagggctg ctgatggccg gctcagtcag 780 tgctatgttt ggttctgctg tgtggcaact cgtggcttcg tttttgaagc tccctatttc 840 tggaacccat tgtattgttg gtgcaactat tggtttctcc ctcgtggcaa aggggcagga 900 gggtgtcaag tggtctgaac tgataaaaat tgtgatgtct tggttcgtgt ccccactgct 960 ttctggaatt atgtctggaa ttttattctt cctggttcgt gcattcatcc tccataaggc 1020 agatccagtt cctaatggtt tgcgagcttt gccagttttc tatgcctgca cagttggaat 1080 aaacctcttt tccatcatgt atactggagc accgttgctg ggctttgaca aacttcctct 1140 gtggggtacc atcctcatct cggtgggatg tgcagttttc tgtgccctta tcgtctggtt 1200 ctttgtatgt cccaggatga agagaaaaat tgaacgagaa ataaagtgta gtccttctga 1260 aagcccctta atggaaaaaa agaatagctt gaaagaagac catgaagaaa caaagttgtc 1320 tgttggtgat attgaaaaca agcatcctgt ttctgaggta gggcctgcca ctgtgcccct 1380 ccaggctgtg gtggaggaga gaacagtctc attcaaactt ggagatttgg aggaagctcc 1440 agagagagag aggcttccca gcgtggactt gaaagaggaa accagcatag atagcaccgt 1500 gaatggtgca gtgcagttgc ctaatgggaa ccttgtccag ttcagtcaag ccgtcagcaa 1560 ccaaataaac tccagtggcc actaccagta tcacaccgtg cataaggatt ccggcctgta 1620 caaagagcta ctccataaat tacatcttgc caaggtggga gattgcatgg gagactccgg 1680 tgacaaaccc ttaaggcgca ataatagcta tacttcctat accatggcaa tatgtggcat 1740 gcctctggat tcattccgtg ccaaagaagg tgaacagaag ggcgaagaaa tggagaagct 1800 gacatggcct aatgcagact ccaagaagcg aattcgaatg gacagttaca ccagttactg 1860 caatgctgtg tctgaccttc actcagcatc tgagatagac atgagtgtca aggcagagat 1920 gggtctaggt gacagaaaag gaagtaatgg ctctctagaa gaatggtatg accaggataa 1980 gcctgaagtc tctctcctct tccagttcct gcagatcctt acagcctgct ttgggtcatt 2040 cgcccatggt ggcaatgacg taagcaatgc cattgggcct ctggttgctt tatatttggt 2100 ttatgacaca ggagatgttt cttcaaaagt ggcaacacca atatggcttc tactctatgg 2160 tggtgttggt atctgtgttg gtctgtgggt ttggggaaga agagttatcc agaccatggg 2220 gaaggatctg acaccgatca caccctctag tggcttcagt attgaactgg catctgccct 2280 cactgtggtg attgcatcaa atattggcct tcccatcagt acaacacatt gtaaagtggg 2340 ctctgttgtg tctgttggct ggctccggtc caagaaggct gttgactggc gtctctttcg 2400 taacattttt atggcctggt ttgtcacagt ccccatttct ggagttatca gtgctgccat 2460 catggcaatc ttcagatatg tcatcctcag aatgtgaagc tgtttgagat taaaatttgt 2520 gtcaatgttt gggaccatct taggtattcc tgctcccctg aagaatgatt acagtgttaa 2580 cagaagactg acaagagtct ttttatttgg gagccagagg agggaagtgt tacttgtgct 2640 ataactgctt ttgtgctaaa tatgaattgt ctcaaaatta gctgtgtaaa atagcccggg 2700 ttccactggc tcctgctgag gtcccctttc cttctgggct gtgaattcct gtacatattt 2760 ctctactttt tgtatcaggc ttcaattcca ttatgtttta atgttgtctc tgaagatgac 2820 ttgtgatttt tttttctttt ttttaaacca tgaagagccg tttgacagag catgctctgc 2880 gttgttggtt tcaccagctt ctgccctcac atgcacaggg atttaacaac aaaaatataa 2940 ctacaacttc ccttgtagtc tcttatataa gtagagtcct tggtactctg ccctcctgtc 3000 agtagtggca ggatctattg gcatattcgg gagcttctta gagggatgag gttctttgaa 3060 cacagtgaaa atttaaatta gtaacttttt tgcaagcagt ttattgactg ttattgctaa 3120 gaagaagtaa gaaagaaaaa gcctgttggc aatcttggtt atttctttaa gatttctggc 3180 agtgtgggat ggatgaatga agtggaatgt gaactttggg caagttaagt gggacagcct 3240 tccatgttca tttgtctacc tcttaactga ataaaaaagc ctacagtttt tagaaaa 3297 <210> 262 <211> 8057 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(8057) <223> SLIT2 mRNA <400> 262 acttggtgtt atttatttgg gaagcgcccg gacggcggag cttggcggcg gcggtggtgg 60 tggctgccgc agactgtggt taaaaaaaag aaggcggcgg cggcggcggc ggcggaggcg 120 gaggcagctg cgaggcatgg gagcgccgaa gcgcccaggc gcaggccgaa gctgccgcgc 180 tttctgggca cggcgggagt gctgagcaga aaggggagcg ccgggggccc gcagccggct 240 ccggaggcgc gggccgggtt tttgtttggc tacgctgagc gccagtcagc cccagcgaac 300 aactccagtt acgacaacaa cccaccttcc ttccagacaa gcgagacttg ggctgctgcg 360 tccgtcctat tgtttagaca cttgccaggg gctccggagt cggcagagcc accgagtccc 420 cgctctgagt cgtcgccctc cctctccccg acctcgctcc ctggagcggg aggccaggaa 480 agcagcggga gaggggaagg ggctagaagg agaaggacta cccgggactg cggccgccgc 540 gtcaggtgca gcgccaggag ccgggcggcg tcgccacgcc ggcaggggta ccgccactgt 600 ggccttgggg gacggaattc aaagcctggg aaaagttgct gcactttgag aaggacgaac 660 cactagtggg agaccgccgg gggccggccg tggctctgcg ccctccggaa cccggctctt 720 gtttcttcta cctttgccat caggtgtctg ccgcggagct gcggcttatc tgggagacga 780 gcggggttga cacgcgcgca cacactactg ccattcagct gccgcctggc tctgcctgga 840 gtagtggatc ccacccgccc acctgccacc gagccattct ccagtacgcc ccagcaggac 900 gctgacacct ccaaccttgg cctttgcctt tccactcctt ccggtctgcc tggtttttaa 960 gtccgccccc agtcagtccc cactcagtct tcgcagcagc tctcatcctc cacttggcct 1020 cttggagttc ctcgccggag tgctgactag tggatatttc tgcccggctg cggcggcccg 1080 actgcccttt tgtcttttct gcgtgacctc ggggcaggtc ctggtgcaga gcgtcgccaa 1140 ggacgccgag cgggaggcgg gattgcccag acatccttca gcgaagtgca tgtgtgtttg 1200 taaaccatcg ttggctgtcg ggagaccgcg aggaccggtc caggctgcgg cggagtcgag 1260 ggcgagggag aggccgcgtg agtgagcaga gtccagagcc gtgcgccccc agaactgcgc 1320 gtccgccccg tgcacccccg cgcgccatgc ccagttgccc cgcgcgctct gctacgggcc 1380 cgctgggctt ccgcgccttc tagcttccgg agcccacttt gatcggggcc ataataccta 1440 ttgagatccc ctcttctgtc ttgtaccttc gccactggca tcggatttgc agaagcgtgc 1500 gtgggatcag aggaccgccc tccccacaac aaccggcccc tgcatcttag cagccgttgg 1560 aagccccagc tcttttaccg ccaagttcat ccttgggaga cagaagacgc gtgatctcct 1620 ctccgctgct cttggggtct ccttgcagcc ctggccaggc ggattcatcc tcaggaccta 1680 aagttgccca aggagctcct gctctgccag aggagggtgg agagggcggt gggaggcgtg 1740 tgcctgagtg ggctctactg ccttgttcca tattatttgg tgcacatttt ccctggcact 1800 ctgggttgct agccccgccg ggcactgggc ctcagacact gcgcggttcc ctcggagcag 1860 caagctaaag aaagccccca gtgccggcga ggaaggaggc ggcggggaaa gatgcgcggc 1920 gttggctggc agatgctgtc cctgtcgctg gggttagtgc tggcgatcct gaacaaggtg 1980 gcaccgcagg cgtgcccggc gcagtgctct tgctcgggca gcacagtgga ctgtcacggg 2040 ctggcgctgc gcagcgtgcc caggaatatc ccccgcaaca ccgagagact ggatttaaat 2100 ggaaataaca tcacaagaat tacgaagaca gattttgctg gtcttagaca tctaagagtt 2160 cttcagctta tggagaataa gattagcacc attgaaagag gagcattcca ggatcttaaa 2220 gaactagaga gactgcgttt aaacagaaat caccttcagc tgtttcctga gttgctgttt 2280 cttgggactg cgaagctata caggcttgat ctcagtgaaa accaaattca ggcaatccca 2340 aggaaagctt tccgtggggc agttgacata aaaaatttgc aactggatta caaccagatc 2400 agctgtattg aagatggggc attcagggct ctccgggacc tggaagtgct cactctcaac 2460 aataacaaca ttactagact ttctgtggca agtttcaacc atatgcctaa acttaggact 2520 tttcgactgc attcaaacaa cctgtattgt gactgccacc tggcctggct ctccgactgg 2580 cttcgccaaa ggcctcgggt tggtctgtac actcagtgta tgggcccctc ccacctgaga 2640 ggccataatg tagccgaggt tcaaaaacga gaatttgtct gcagtggtca ccagtcattt 2700 atggctcctt cttgtagtgt tttgcactgc cctgccgcct gtacctgtag caacaatatc 2760 gtagactgtc gtgggaaagg tctcactgag atccccacaa atcttccaga gaccatcaca 2820 gaaatacgtt tggaacagaa cacaatcaaa gtcatccctc ctggagcttt ctcaccatat 2880 aaaaagctta gacgaattga cctgagcaat aatcagatct ctgaacttgc accagatgct 2940 ttccaaggac tacgctctct gaattcactt gtcctctatg gaaataaaat cacagaactc 3000 cccaaaagtt tatttgaagg actgttttcc ttacagctcc tattattgaa tgccaacaag 3060 ataaactgcc ttcgggtaga tgcttttcag gatctccaca acttgaacct tctctcccta 3120 tatgacaaca agcttcagac catcgccaag gggacctttt cacctcttcg ggccattcaa 3180 actatgcatt tggcccagaa cccctttatt tgtgactgcc atctcaagtg gctagcggat 3240 tatctccata ccaacccgat tgagaccagt ggtgcccgtt gcaccagccc ccgccgcctg 3300 gcaaacaaaa gaattggaca gatcaaaagc aagaaattcc gttgttcagc taaagaacag 3360 tatttcattc caggtacaga agattatcga tcaaaattaa gtggagactg ctttgcggat 3420 ctggcttgcc ctgaaaagtg tcgctgtgaa ggaaccacag tagattgctc taatcaaaag 3480 ctcaacaaaa tcccggagca cattccccag tacactgcag agttgcgtct caataataat 3540 gaatttaccg tgttggaagc cacaggaatc tttaagaaac ttcctcaatt acgtaaaata 3600 aactttagca acaataagat cacagatatt gaggagggag catttgaagg agcatctggt 3660 gtaaatgaaa tacttcttac gagtaatcgt ttggaaaatg tgcagcataa gatgttcaag 3720 ggattggaaa gcctcaaaac tttgatgttg agaagcaatc gaataacctg tgtggggaat 3780 gacagtttca taggactcag ttctgtgcgt ttgctttctt tgtatgataa tcaaattact 3840 acagttgcac caggggcatt tgatactctc cattctttat ctactctaaa cctcttggcc 3900 aatcctttta actgtaactg ctacctggct tggttgggag agtggctgag aaagaagaga 3960 attgtcacgg gaaatcctag atgtcaaaaa ccatacttcc tgaaagaaat acccatccag 4020 gatgtggcca ttcaggactt cacttgtgat gacggaaatg atgacaatag ttgctcccca 4080 ctttctcgct gtcctactga atgtacttgc ttggatacag tcgtccgatg tagcaacaag 4140 ggtttgaagg tcttgccgaa aggtattcca agagatgtca cagagttgta tctggatgga 4200 aaccaattta cactggttcc caaggaactc tccaactaca aacatttaac acttatagac 4260 ttaagtaaca acagaataag cacgctttct aatcagagct tcagcaacat gacccagctc 4320 ctcaccttaa ttcttagtta caaccgtctg agatgtattc ctcctcgcac ctttgatgga 4380 ttaaagtctc ttcgattact ttctctacat ggaaatgaca tttctgttgt gcctgaaggt 4440 gctttcaatg atctttctgc attatcacat ctagcaattg gagccaaccc tctttactgt 4500 gattgtaaca tgcagtggtt atccgactgg gtgaagtcgg aatataagga gcctggaatt 4560 gctcgttgtg ctggtcctgg agaaatggca gataaacttt tactcacaac tccctccaaa 4620 aaatttacct gtcaaggtcc tgtggatgtc aatattctag ctaagtgtaa cccctgccta 4680 tcaaatccgt gtaaaaatga tggcacatgt aatagtgatc cagttgactt ttaccgatgc 4740 acctgtccat atggtttcaa ggggcaggac tgtgatgtcc caattcatgc ctgcatcagt 4800 aacccatgta aacatggagg aacttgccac ttaaaggaag gagaagaaga tggattctgg 4860 tgtatttgtg ctgatggatt tgaaggagaa aattgtgaag tcaacgttga tgattgtgaa 4920 gataatgact gtgaaaataa ttctacatgt gtcgatggca ttaataacta cacatgcctt 4980 tgcccacctg agtatacagg tgagttgtgt gaggagaagc tggacttctg tgcccaggac 5040 ctgaacccct gccagcacga ttcaaagtgc atcctaactc caaagggatt caaatgtgac 5100 tgcacaccag ggtacgtagg tgaacactgc gacatcgatt ttgacgactg ccaagacaac 5160 aagtgtaaaa acggagccca ctgcacagat gcagtgaacg gctatacgtg catatgcccc 5220 gaaggttaca gtggcttgtt ctgtgagttt tctccaccca tggtcctccc tcgtaccagc 5280 ccctgtgata attttgattg tcagaatgga gctcagtgta tcgtcagaat aaatgagcca 5340 atatgtcagt gtttgcctgg ctatcaggga gaaaagtgtg aaaaattggt tagtgtgaat 5400 tttataaaca aagagtctta tcttcagatt ccttcagcca aggttcggcc tcagacgaac 5460 ataacacttc agattgccac agatgaagac agcggaatcc tcctgtataa gggtgacaaa 5520 gaccatatcg cggtagaact ctatcggggg cgtgttcgtg ccagctatga caccggctct 5580 catccagctt ctgccattta cagtgtggag acaatcaatg atggaaactt ccacattgtg 5640 gaactacttg ccttggatca gagtctctct ttgtccgtgg atggtgggaa ccccaaaatc 5700 atcactaact tgtcaaagca gtccactctg aattttgact ctccactcta tgtaggaggc 5760 atgccaggga agagtaacgt ggcatctctg cgccaggccc ctgggcagaa cggaaccagc 5820 ttccacggct gcatccggaa cctttacatc aacagtgagc tgcaggactt ccagaaggtg 5880 ccgatgcaaa caggcatttt gcctggctgt gagccatgcc acaagaaggt gtgtgcccat 5940 ggcacatgcc agcccagcag ccaggcaggc ttcacctgcg agtgccagga aggatggatg 6000 gggcccctct gtgaccaacg gaccaatgac ccttgccttg gaaataaatg cgtacatggc 6060 acctgcttgc ccatcaatgc gttctcctac agctgtaagt gcttggaggg ccatggaggt 6120 gtcctctgtg atgaagagga ggatctgttt aacccatgcc aggcgatcaa gtgcaagcat 6180 gggaagtgca ggctttcagg tctggggcag ccctactgtg aatgcagcag tggatacacg 6240 ggggacagct gtgatcgaga aatctcttgt cgaggggaaa ggataagaga ttattaccaa 6300 aagcagcagg gctatgctgc ttgccaaaca accaagaagg tgtcccgatt agagtgcaga 6360 ggtgggtgtg caggagggca gtgctgtgga ccgctgagga gcaagcggcg gaaatactct 6420 ttcgaatgca ctgacggctc ctcctttgtg gacgaggttg agaaagtggt gaagtgcggc 6480 tgtacgaggt gtgtgtccta aacacactcc cggcagctct gtctttggaa aaggttgtat 6540 acttcttgac cgtgtgggac taatgaatgc ttcatagtgg aaatatttga aatatattgt 6600 aaaatacaga acagacttat ttttattatg agaataaaga ctttttttct gcatttggaa 6660 aaaaaaaaaa agaaatgctt gaactaaagc ttcccctatg ctggagaagt atgaagaaag 6720 atatacctgg agacattaga acagcgatgg gaaccattgc aactcgggtc catctttgta 6780 acatgctgaa gacaagcaga agcacatgca cgagggacag aggagctact gtgcactgct 6840 gtgaaattgc ccagagcata aaacctgtgt accctccttc acatcaacca agttcactag 6900 gacataccaa gcacatgcgt gtgaatgagg atgcaaggca agagaatgga actccagaat 6960 tcacagatag aacaaatgga tgagaaatat ttcatgcaaa atataaagtg tcctgaggat 7020 ctgggttcca tttacgagag gaaatgaaag tgctaaaata aattttatct tccttttaaa 7080 tgtcagcatg tcagcagaag cagcacacaa aagtctttac cattttccag tattaatttt 7140 tttgtaatat aaatgataaa ggagatgata aagaaccaat agattattga taaataaatt 7200 agtaataata tgattttttg tttctatgag ttctaaacag ccctatacag tattcagttt 7260 ccatgagaaa tatttattgt atcaaagtac attgtactta acattttagg ccatcctttt 7320 actgttcctt gatgctttaa tatatattaa tttataatta tcctgatatt tttgtacatt 7380 tttcaaactt aaaaatcagg attttttttt tttttttttt ggcaatagta ctaacatagg 7440 gttttatctt gggatacata tgtattggtc tgtttgttga ccttgacatc tgatcactga 7500 tgtcaatgac ctactggcct cattcaggac acctgcagag agtatgcaaa gtccgagaga 7560 ggaaaacaga aatctgtatg tgagatggtc attgtacaga aagaagtggc ccctctgcaa 7620 catgtcctca cagaaacgaa atggtgtgta gcaatcaaca ctagaaagta gaccttttgc 7680 aaattaatat gtccttgacc ttttttgccc ttttgtgggg gtgaggtggg gataaaaaga 7740 ctgtcatatc aagaactgtg acttttcttt ccctcaaaca ataaaactcc tttattatct 7800 taatgctccc atgttaacat gtttgctgct aaattacaat gtagaattga taatggttta 7860 tagtgaactg tgctcttccc tcattaaaat cccagggtgc cctgtaaaga tgcagatgtt 7920 tcttcctgaa aacttctttt tttacaaaga aaattagatg tacatgtata attcagtgtg 7980 ctttgtcttt ctccagatta atatcggtta cactgctgat gtttgtaaat taaacagata 8040 tttacttcat taaaaaa 8057 <210> 263 <211> 6240 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6240) <223> SMURF2 mRNA <400> 263 agacaagagg gcgggtggag gaggaagcgg ccgagcccag agttctgctc cggcgccccc 60 gagcaccgcc cgcttcagcc gaccagcccc gtcggctact gggcctcgcc gagacgagag 120 gagggaaagg cctcggcggc cgcgaggagg cggcgggggc gcgggcggag gcggcgcggg 180 cggccgcggc tgccgctttg ttgtgcggcc cgggccgagg aaggagaagt gggaggaggg 240 gggagctcgg cgtcccgctc cctccgcggc tcatggcgac gactctcggc acatccggga 300 ccctccggcc gtggcggccg aggcgccggc tgctcgggcc ccagccccgg ccgctgtggt 360 gactccgccg cgcctcgccg tcgcccccgt gccgcccgcc gcccccgccg cccccgccgc 420 cggggacatg tctaaccccg gaggccggag gaacgggccc gtcaagctgc gcctgacagt 480 actctgtgca aaaaacctgg tgaaaaagga ttttttccga cttcctgatc catttgctaa 540 ggtggtggtt gatggatctg ggcaatgcca ttctacagat actgtgaaga atacgcttga 600 tccaaagtgg aatcagcatt atgacctgta tattggaaag tctgattcag ttacgatcag 660 tgtatggaat cacaagaaga tccataagaa acaaggtgct ggatttctcg gttgtgttcg 720 tcttctttcc aatgccatca accgcctcaa agacactggt tatcagaggt tggatttatg 780 caaactcggg ccaaatgaca atgatacagt tagaggacag atagtagtaa gtcttcagtc 840 cagagaccga ataggcacag gaggacaagt tgtggactgc agtcgtttat ttgataacga 900 tttaccagac ggctgggaag aaaggagaac cgcctctgga agaatccagt atctaaacca 960 tataacaaga actacgcaat gggagcgccc aacacgaccg gcatccgaat attctagccc 1020 tggcagacct cttagctgct ttgttgatga gaacactcca attagtggaa caaatggtgc 1080 aacatgtgga cagtcttcag atcccaggct ggcagagagg agagtcaggt cacaacgaca 1140 tagaaattac atgagcagaa cacatttaca tactcctcca gacctaccag aaggctatga 1200 acagaggaca acgcaacaag gccaggtgta tttcttacat acacagactg gtgtgagcac 1260 atggcatgat ccaagagtgc ccagggatct tagcaacatc aattgtgaag agcttggtcc 1320 attgcctcct ggatgggaga tccgtaatac ggcaacaggc agagtttatt tcgttgacca 1380 taacaacaga acaacacaat ttacagatcc tcggctgtct gctaacttgc atttagtttt 1440 aaatcggcag aaccaattga aagaccaaca gcaacagcaa gtggtatcgt tatgtcctga 1500 tgacacagaa tgcctgacag tcccaaggta caagcgagac ctggttcaga aactaaaaat 1560 tttgcggcaa gaactttccc aacaacagcc tcaggcaggt cattgccgca ttgaggtttc 1620 cagggaagag atttttgagg aatcatatcg acaggtcatg aaaatgagac caaaagatct 1680 ctggaagcga ttaatgataa aatttcgtgg agaagaaggc cttgactatg gaggcgttgc 1740 cagggaatgg ttgtatctct tgtcacatga aatgttgaat ccatactatg gcctcttcca 1800 gtattcaaga gatgatattt atacattgca gatcaatcct gattctgcag ttaatccgga 1860 acatttatcc tatttccact ttgttggacg aataatggga atggctgtgt ttcatggaca 1920 ttatattgat ggtggtttca cattgccttt ttataagcaa ttgcttggga agtcaattac 1980 cttggatgac atggagttag tagatccgga tcttcacaac agtttagtgt ggatacttga 2040 gaatgatatt acaggtgttt tggaccatac cttctgtgtt gaacataatg catatggtga 2100 aattattcag catgaactta aaccaaatgg caaaagtatc cctgttaatg aagaaaataa 2160 aaaagaatat gtcaggctct atgtgaactg gagattttta cgaggcattg aggctcaatt 2220 cttggctctg cagaaaggat ttaatgaagt aattccacaa catctgctga agacatttga 2280 tgagaaggag ttagagctca ttatttgtgg acttggaaag atagatgtta atgactggaa 2340 ggtaaacacc cggttaaaac actgtacacc agacagcaac attgtcaaat ggttctggaa 2400 agctgtggag ttttttgatg aagagcgacg agcaagattg cttcagtttg tgacaggatc 2460 ctctcgagtg cctctgcagg gcttcaaagc attgcaaggt gctgcaggcc cgagactctt 2520 taccatacac cagattgatg cctgcactaa caacctgccg aaagcccaca cttgcttcaa 2580 tcgaatagac attccaccct atgaaagcta tgaaaagcta tatgaaaagc tgctaacagc 2640 cattgaagaa acatgtggat ttgctgtgga atgacaagct tcaaggattt acccaggact 2700 ctatttatac aaccctgact gacagcctcc tttcagcaga gtttcaaaga atatgctgaa 2760 atacaggaaa acactccccc cccccccctt tttttttttt tttttacatt ttaggacact 2820 gtgaggggaa aggacaattt tgaaattcct tttcaaggaa aaaaaaggtc tttatgcttt 2880 gccatgaggc cacattcagc tgctatttaa acttaatatc ttgaacctaa agaatgctga 2940 cttttcctac atttccagag ttaggcagta ttctacactt aaagactact actattttta 3000 taaaaggtaa tctattcaaa tttcttcaca gatttcaagt ctctcaaaca tcaagacaac 3060 ttcagcagtc ggtacaagtc acatttcatt ttgattgaat acatgatctt gaacagctcc 3120 tgtacttgct ctttgtaaaa aaaaataaaa ttattttgaa ttattctacc tttgtaaaca 3180 attggctaaa agaatcatct ttaagaaatt aagccattta catgtttgtg tttttctata 3240 gcagagcatt atattttgca ttatatgttt caacctagtc taagtgggtc ttttttacat 3300 ttttcaagaa cggatttcct ggaatacagc gatataattt tggttgtcaa attcctaatg 3360 caaccattta gtctaaactt agtcatttat ttgtgacaat aagatgtgtt caggggctcc 3420 ctgtttttaa gagactcttt taaaaaaaaa aaaacctaat gtttttatct tgagtcaata 3480 tgattaggta ttttggattt acttttaatc ttaaaatact gcatttttat agcttctcag 3540 agcatgtgga tgggatggga ttttcgttat tttgctgggt cagcttatct ttaatatatg 3600 gactattcct ataaaccaaa gtctctgaca agtgcaccta atttatattg tattttaact 3660 acagtgtaag tttccattaa caaaaccatc ctaaagcgtt aactgctcat aattttaatc 3720 agctacagtt atgaaaaagg aagaattttg ctctaaagat tattaataag cttagaaaat 3780 cctgctttta cctaacagaa tgaagtgggg ttgaggggcg gtagtatgaa cagtgattct 3840 aactctatgg cgtaaattac tttgaagagt tcattttgga agtaagggaa tcccgcttcc 3900 cttggtgttg aagatctgca tctgattttg aaacgtccag atttagcttt caaggtgcgt 3960 gcatgttgaa tgatccagaa gcaacgaaaa ctctggggtg agggattgaa aaaatctgaa 4020 atcacagttg gatttttaaa ttcaaccatc aaaaatatgt actatcagtt tttttttaca 4080 ttgatgtgaa ataagcaaat tttcatgata attaagctgc aaaatttaaa gttatcaagt 4140 aaataggtcc tctgtgttct gtttcatgtg atggagtggg tttcagtctg tgttcttgga 4200 gccaaagggt tcctcagggg tgcctcagga gtaatggttt aagagaagag gggcaatgag 4260 agggagcgag ggggaaggcc tagttggtat ttgagcaggg gccttaggct ccatatcccc 4320 acccccttta cccagaacag cccatttttc ttatgtatat tggaatttca agtaagcttt 4380 catggggtgc agtggggcgg ggaggaatgg atgggataaa aaaagtggag attttgctgc 4440 tttaaaaaag ttgagaacta cttgtgtagt ttttaagtat tttaatgtat ttcatttggc 4500 caaattcaac tgccacaagc aagctagtca tagttgtaac tgtgcagtgg taatatgctt 4560 atgcctacct ttttcctctc aaacaatttg ttttttttac attgcattct gagtactgaa 4620 gagcatcttg aaatgtatgg aagtggtttc tatgctattt gataatcagt aatgttcagc 4680 tgtcatgata gtactttact ggttgcagac ccatctctct tttatattaa agcactagtg 4740 cagtttataa ttgtgcctac ttttaaaatc tttcagtaaa aaagtacata atgaatacag 4800 aaatcataac tgacagggat acagtaataa tgaaatgcta ctatcactta ttttaatata 4860 caatataaag caggcaaata ccattgcttt ttgagtgcct ttttaacttt atactaatga 4920 cttaatagag ctttaaaaga aagaaattgg ctgggcatgg tggctcacac ctgtaatccc 4980 agcactttgg gaggccgagg tgggcggatc acctgaggtc aggagttcga gaccagcctg 5040 gccaacgtgg tgaaaccctg tctctactaa aaatacaaaa tttagccggg catggtggcg 5100 cactcctgta atccaactac ttgggaggct gaggcaggag aattgcttga atctgggagg 5160 cagagattgc agtgagccga gatcgcacca ctgcactcca gcctgggcga caagagtgag 5220 actccgtccc cgcccaaaaa aaaaaaaaaa agaaattact ctccataaca gtctatgtta 5280 tcaccaacat atataaaaac atgatttaga tttccatttc aaagttacat tacccgatta 5340 cttccaaata ggtgctaagc aaaaaccccc aatgtattat tgaaccatgg acttgcacct 5400 catgtttaat gtgaatattt atttccatgt ccctcttaac tggttttttc ttgtcttccc 5460 tctagctgta ttgttatttc agatatgtga tatctgtttt catactcttg cctttccatc 5520 atgaatgctt agttatgaac agagattcct ttgtagagct cataggcagt acagagaggt 5580 aagtcttgcc tcagagggcc ttgtatcttg gtgtagtttt taaatagtgc atagtgtata 5640 gtgtatagtg tacattttgt tttgcacata gtttgttgcc ccgaatgggt tttttaccaa 5700 gccttttttt ctttcatgta tttacagtcc ggagcacaag attctcttct ttcaaataca 5760 atgtaattcg ctttacttta caacactaaa tctgggcttt gaatttccag tgcattggac 5820 tgattggatt gttgggagtt agaggctgtt ccaaccatcc ttagtttggg agagtggctc 5880 cttctgcttg ttttctaagc gtacagtcaa cgggtgccat ttgtggtatt taacatgtta 5940 ggatgattgt tccaaatgct gagttgtttt atttctagat gtaattagtt cactttatgt 6000 aatattcttc tctcagactg actttaaaaa caaagtttta tcattttcat tgtatttgta 6060 tttattacag agtgttttag ctttgatatt ctttgtattt tcattcattt gttacatgag 6120 ctttatcagt aacatctgta taaatggttt ttaaaaatta actatgtatg tgcccatgcc 6180 gaagtcgagc aataaaatca atgctgtttg cactgtcaca gcatcaacgt ttttaaagaa 6240 6240 <210> 264 <211> 4978 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4978) <223> STAT3 mRNA <400> 264 ggtttccgga gctgcggcgg cgcagactgg gagggggagc cgggggttcc gacgtcgcag 60 ccgagggaac aagccccaac cggatcctgg acaggcaccc cggcttggcg ctgtctctcc 120 ccctcggctc ggagaggccc ttcggcctga gggagcctcg ccgcccgtcc ccggcacacg 180 cgcagccccg gcctctcggc ctctgccgga gaaacagttg ggacccctga ttttagcagg 240 atggcccaat ggaatcagct acagcagctt gacacacggt acctggagca gctccatcag 300 ctctacagtg acagcttccc aatggagctg cggcagtttc tggccccttg gattgagagt 360 caagattggg catatgcggc cagcaaagaa tcacatgcca ctttggtgtt tcataatctc 420 ctgggagaga ttgaccagca gtatagccgc ttcctgcaag agtcgaatgt tctctatcag 480 cacaatctac gaagaatcaa gcagtttctt cagagcaggt atcttgagaa gccaatggag 540 attgcccgga ttgtggcccg gtgcctgtgg gaagaatcac gccttctaca gactgcagcc 600 actgcggccc agcaaggggg ccaggccaac caccccacag cagccgtggt gacggagaag 660 cagcagatgc tggagcagca ccttcaggat gtccggaaga gagtgcagga tctagaacag 720 aaaatgaaag tggtagagaa tctccaggat gactttgatt tcaactataa aaccctcaag 780 agtcaaggag acatgcaaga tctgaatgga aacaaccagt cagtgaccag gcagaagatg 840 cagcagctgg aacagatgct cactgcgctg gaccagatgc ggagaagcat cgtgagtgag 900 ctggcggggc ttttgtcagc gatggagtac gtgcagaaaa ctctcacgga cgaggagctg 960 gctgactgga agaggcggca acagattgcc tgcattggag gcccgcccaa catctgccta 1020 gatcggctag aaaactggat aacgtcatta gcagaatctc aacttcagac ccgtcaacaa 1080 attaagaaac tggaggagtt gcagcaaaaa gtttcctaca aaggggaccc cattgtacag 1140 caccggccga tgctggagga gagaatcgtg gagctgttta gaaacttaat gaaaagtgcc 1200 tttgtggtgg agcggcagcc ctgcatgccc atgcatcctg accggcccct cgtcatcaag 1260 accggcgtcc agttcactac taaagtcagg ttgctggtca aattccctga gttgaattat 1320 cagcttaaaa ttaaagtgtg cattgacaaa gactctgggg acgttgcagc tctcagagga 1380 tcccggaaat ttaacattct gggcacaaac acaaaagtga tgaacatgga agaatccaac 1440 aacggcagcc tctctgcaga attcaaacac ttgaccctga gggagcagag atgtgggaat 1500 gggggccgag ccaattgtga tgcttccctg attgtgactg aggagctgca cctgatcacc 1560 tttgagaccg aggtgtatca ccaaggcctc aagattgacc tagagaccca ctccttgcca 1620 gttgtggtga tctccaacat ctgtcagatg ccaaatgcct gggcgtccat cctgtggtac 1680 aacatgctga ccaacaatcc caagaatgta aactttttta ccaagccccc aattggaacc 1740 tgggatcaag tggccgaggt cctgagctgg cagttctcct ccaccaccaa gcgaggactg 1800 agcatcgagc agctgactac actggcagag aaactcttgg gacctggtgt gaattattca 1860 gggtgtcaga tcacatgggc taaattttgc aaagaaaaca tggctggcaa gggcttctcc 1920 ttctgggtct ggctggacaa tatcattgac cttgtgaaaa agtacatcct ggccctttgg 1980 aacgaagggt acatcatggg ctttatcagt aaggagcggg agcgggccat cttgagcact 2040 aagcctccag gcaccttcct gctaagattc agtgaaagca gcaaagaagg aggcgtcact 2100 ttcacttggg tggagaagga catcagcggt aagacccaga tccagtccgt ggaaccatac 2160 acaaagcagc agctgaacaa catgtcattt gctgaaatca tcatgggcta taagatcatg 2220 gatgctacca atatcctggt gtctccactg gtctatctct atcctgacat tcccaaggag 2280 gaggcattcg gaaagtattg tcggccagag agccaggagc atcctgaagc tgacccaggt 2340 agcgctgccc catacctgaa gaccaagttt atctgtgtga caccaacgac ctgcagcaat 2400 accattgacc tgccgatgtc cccccgcact ttagattcat tgatgcagtt tggaaataat 2460 ggtgaaggtg ctgaaccctc agcaggaggg cagtttgagt ccctcacctt tgacatggag 2520 ttgacctcgg agtgcgctac ctcccccatg tgaggagctg agaacggaag ctgcagaaag 2580 atacgactga ggcgcctacc tgcattctgc cacccctcac acagccaaac cccagatcat 2640 ctgaaactac taactttgtg gttccagatt ttttttaatc tcctacttct gctatctttg 2700 agcaatctgg gcacttttaa aaatagagaa atgagtgaat gtgggtgatc tgcttttatc 2760 taaatgcaaa taaggatgtg ttctctgaga cccatgatca ggggatgtgg cggggggtgg 2820 ctagagggag aaaaaggaaa tgtcttgtgt tgttttgttc ccctgccctc ctttctcagc 2880 agctttttgt tattgttgtt gttgttctta gacaagtgcc tcctggtgcc tgcggcatcc 2940 ttctgcctgt ttctgtaagc aaatgccaca ggccacctat agctacatac tcctggcatt 3000 gcacttttta accttgctga catccaaata gaagatagga ctatctaagc cctaggtttc 3060 tttttaaatt aagaaataat aacaattaaa gggcaaaaaa cactgtatca gcatagcctt 3120 tctgtattta agaaacttaa gcagccgggc atggtggctc acgcctgtaa tcccagcact 3180 ttgggaggcc gaggcggatc ataaggtcag gagatcaaga ccatcctggc taacacggtg 3240 aaaccccgtc tctactaaaa gtacaaaaaa ttagctgggt gtggtggtgg gcgcctgtag 3300 tcccagctac tcgggaggct gaggcaggag aatcgcttga acctgagagg cggaggttgc 3360 agtgagccaa aattgcacca ctgcacactg cactccatcc tgggcgacag tctgagactc 3420 tgtctcaaaa aaaaaaaaaa aaaaaagaaa cttcagttaa cagcctcctt ggtgctttaa 3480 gcattcagct tccttcaggc tggtaattta tataatccct gaaacgggct tcaggtcaaa 3540 cccttaagac atctgaagct gcaacctggc ctttggtgtt gaaataggaa ggtttaagga 3600 gaatctaagc attttagact tttttttata aatagactta ttttcctttg taatgtattg 3660 gccttttagt gagtaaggct gggcagaggg tgcttacaac cttgactccc tttctccctg 3720 gacttgatct gctgtttcag aggctaggtt gtttctgtgg gtgccttatc agggctggga 3780 tacttctgat tctggcttcc ttcctgcccc accctcccga ccccagtccc cctgatcctg 3840 ctagaggcat gtctccttgc gtgtctaaag gtccctcatc ctgtttgttt taggaatcct 3900 ggtctcagga cctcatggaa gaagaggggg agagagttac aggttggaca tgatgcacac 3960 tatggggccc cagcgacgtg tctggttgag ctcagggaat atggttctta gccagtttct 4020 tggtgatatc cagtggcact tgtaatggcg tcttcattca gttcatgcag ggcaaaggct 4080 tactgataaa cttgagtctg ccctcgtatg agggtgtata cctggcctcc ctctgaggct 4140 ggtgactcct ccctgctggg gccccacagg tgaggcagaa cagctagagg gcctccccgc 4200 ctgcccgcct tggctggcta gctcgcctct cctgtgcgta tgggaacacc tagcacgtgc 4260 tggatgggct gcctctgact cagaggcatg gccggatttg gcaactcaaa accaccttgc 4320 ctcagctgat cagagtttct gtggaattct gtttgttaaa tcaaattagc tggtctctga 4380 attaaggggg agacgacctt ctctaagatg aacagggttc gccccagtcc tcctgcctgg 4440 agacagttga tgtgtcatgc agagctctta cttctccagc aacactcttc agtacataat 4500 aagcttaact gataaacaga atatttagaa aggtgagact tgggcttacc attgggttta 4560 aatcataggg acctagggcg agggttcagg gcttctctgg agcagatatt gtcaagttca 4620 tggccttagg tagcatgtat ctggtcttaa ctctgattgt agcaaaagtt ctgagaggag 4680 ctgagccctg ttgtggccca ttaaagaaca gggtcctcag gccctgcccg cttcctgtcc 4740 actgccccct ccccatcccc agcccagccg agggaatccc gtgggttgct tacctaccta 4800 taaggtggtt tataagctgc tgtcctggcc actgcattca aattccaatg tgtacttcat 4860 agtgtaaaaa tttatattat tgtgaggttt tttgtctttt tttttttttt ttttttttgg 4920 tatattgctg tatctacttt aacttccaga aataaacgtt atataggaac cgtaaaaa 4978 <210> 265 <211> 3868 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3868) <223> STC1 mRNA <400> 265 agtttgcaaa agccagaggt gcaagaagca gcgactgcag cagcagcagc agcagcggcg 60 gtggcagcag cagcagcagc ggcggcagca gcagcagcag cggaggcacc ggtggcagca 120 gcagcatcac cagcaacaac aacaaaaaaa aatcctcatc aaatcctcac ctaagctttc 180 agtgtatcca gatccacatc ttcactcaag ccaggagagg gaaagaggaa aggggggcag 240 gaaaaaaaaa aaacccaaca acttagcgga aacttctcag agaatgctcc aaaactcagc 300 agtgcttctg gtgctggtga tcagtgcttc tgcaacccat gaggcggagc agaatgactc 360 tgtgagcccc aggaaatccc gagtggcggc tcaaaactca gctgaagtgg ttcgttgcct 420 caacagtgct ctacaggtcg gctgcggggc ttttgcatgc ctggaaaact ccacctgtga 480 cacagatggg atgtatgaca tctgtaaatc cttcttgtac agcgctgcta aatttgacac 540 tcagggaaaa gcattcgtca aagagagctt aaaatgcatc gccaacgggg tcacctccaa 600 ggtcttcctc gccattcgga ggtgctccac tttccaaagg atgattgctg aggtgcagga 660 agagtgctac agcaagctga atgtgtgcag catcgccaag cggaaccctg aagccatcac 720 tgaggtcgtc cagctgccca atcacttctc caacagatac tataacagac ttgtccgaag 780 cctgctggaa tgtgatgaag acacagtcag cacaatcaga gacagcctga tggagaaaat 840 tgggcctaac atggccagcc tcttccacat cctgcagaca gaccactgtg cccaaacaca 900 cccacgagct gacttcaaca ggagacgcac caatgagccg cagaagctga aagtcctcct 960 caggaacctc cgaggtgagg aggactctcc ctcccacatc aaacgcacat cccatgagag 1020 tgcataacca gggagaggtt attcacaacc tcaccaaact agtatcattt taggggtgtt 1080 gacacaccag ttttgagtgt actgtgcctg gtttgatttt tttaaagtag ttcctatttt 1140 ctatccccct taaagaaaat tgcatgaaac taggcttctg taatcaatat cccaacattc 1200 tgcaatggca gcattcccac caacaaaatc catgtgacca ttctgcctct cctcaggaga 1260 aagtaccctc ttttaccaac ttcctctgcc atgtttttcc cctgctcccc tgagaccacc 1320 cccaaacaca aaacattcat gtaactctcc agccattgta atttgaagat gtggatccct 1380 ttagaacggt tgccccagta gagttagctg ataaggaaac tttatttaaa tgcatgtctt 1440 aaatgctcat aaagatgtta aatggaattc gtgttatgaa tctgtgctgg ccatggacga 1500 atatgaatgt cacatttgaa ttcttgatct ctaatgagct agtgtcttat ggtcttgatc 1560 ctccaatgtc taattttctt tccgacacat ttaccaaatt gcttgagcct ggctgtccaa 1620 ccagactttg agcctgcatc ttcttgcatc taatgaaaaa caaaaagcta acatctttac 1680 gtactgtaac tgctcagagc tttaaaagta tctttaacaa ttgtcttaaa accagagaat 1740 cttaaggtct aactgtggaa tataaatagc tgaaaactaa tgtactgtac ataaattcca 1800 gaggactctg cttaaacaaa gcagtatata ataactttat tgcatataga tttagttttg 1860 taacttagct ttatttttct tttcctggga atggaataac tatctcactt ccagatatcc 1920 acataaatgc tccttgtggc cttttttata actaaggggg tagaagtagt tttaattcaa 1980 catcaaaact taagatgggc ctgtatgaga caggaaaaac caacaggttt atctgaagga 2040 ccccaggtaa gatgttaatc tcccagccca cctcaaccca gaggctactc ttgacttaga 2100 cctatactga aagatctctg tcacatccaa ctggaaattc caggaaccaa aaagagcatc 2160 cctatgggct tggaccactt acagtgtgat aaggcctact atacattagg aagtggcagt 2220 tctttactcg tcccctttca tcggtgcctg gtactctggc aaatgatgat ggggtgggag 2280 actttccatt aaatcaatca ggaatgagtc aatcagcctt taggtcttta gtccggggga 2340 cttggggctg agagagtata aataaccctg ggctgtccag ccttaataga cttctcttac 2400 attttcgtcc tgtagcacgc tgcctgccaa agtagtcctg gcagctggac catctctgta 2460 ggatcgtaaa aaaatagaaa aaaagaaaaa aaaaagaaag aaagagggaa aaagagctgg 2520 tggtttgatc atttctgcca tgatgtttac aagatggcga ccaccaaagt caaacgacta 2580 acctatctat gaacaacagt agtttctcag ggtcactgtc cttgaaccca acagtccctt 2640 atgagcgtca ctgcccacca aaggtcaatg tcaagagagg aagagaggga ggaggggtag 2700 gactgcaggg gccactccaa actcgcttag gtagaaacta ttggtgcttg actctcacta 2760 ggctaaactc aagatttgac caaatcgagt gatagggatc ctggtgggag gagagagggc 2820 acatctccag aaaaatgaaa agcaatacaa ctttaccata aagcctttaa aaccagtaac 2880 gtgctgctca aggaccaaga gcaattgcag cagacccagc agcagcagca gcagcacaaa 2940 cattgctgcc tttgtcccca cacagcctct aagcgtgctg acatcagatt gttaagggca 3000 tttttatact cagaactgtc ccatccccag gtccccaaac ttatggacac tgccttagcc 3060 tcttggaaat caggtagacc atattctaag ttagactctt cccctccctc ccacacttcc 3120 cacccccagg caaggctgac ttctctgaat cagaaaagct attaaagttt gtgtgttgtg 3180 tccattttgc aaacccaact aagccaggac cccaatgcga caagtagttc atgagtattc 3240 ctagcaaatt tctctctttc ttcagttcag tagatttcct tttttctttt cttttttttt 3300 tttttttttt ttggctgtga cctcttcaaa ccgtggtacc cccccttttc tccccacgat 3360 gatatctata tatgtatcta caatacatat atctacacat acagaaagaa gcagttctca 3420 caatgttgct agttttttgc ttctctttcc cccaccctac tccctccaat tcccccttaa 3480 acttccaaag cttcgtcttg tgtttgctgc agagtgattc gggggctgac ctagaccagt 3540 ttgcatgatt cttctcttgt gatttggttg cactttagac atttttgtgc cattatattt 3600 gcattatgta tttataattt aaatgatatt taggtttttg gctgagtact ggaataaaca 3660 gtgagcatat ctggtatatg tcattattta ttgttaaatt acatttttaa gctccatgtg 3720 catataaagg ttatgaaaca tatcatggta atgacagatg caagttattt tatttgctta 3780 tttttataat taaagatgcc atagcataat atgaagcctt tggtgaattc cttctaagat 3840 aaaaataata ataaagtgtt acgtttta 3868 <210> 266 <211> 2613 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2613) <223> SDC4 mRNA <400> 266 actcgccgca gcctgcgcgc cttctccagt ccgcggtgcc atggcccccg cccgtctgtt 60 cgcgctgctg ctgttcttcg taggcggagt cgccgagtcg atccgagaga ctgaggtcat 120 cgacccccag gacctcctag aaggccgata cttctccgga gccctaccag acgatgagga 180 tgtagtgggg cccgggcagg aatctgatga ctttgagctg tctggctctg gagatctgga 240 tgacttggaa gactccatga tcggccctga agttgtccat cccttggtgc ctctagataa 300 ccatatccct gagagggcag ggtctgggag ccaagtcccc accgaaccca agaaactaga 360 ggagaatgag gttatcccca agagaatctc acccgttgaa gagagtgagg atgtgtccaa 420 caaggtgtca atgtccagca ctgtgcaggg cagcaacatc tttgagagaa cggaggtcct 480 ggcagctctg attgtgggtg gcatcgtggg catcctcttt gccgtcttcc tgatcctact 540 gctcatgtac cgtatgaaga agaaggatga aggcagctat gacctgggca agaaacccat 600 ctacaagaaa gcccccacca atgagttcta cgcgtgaagc ttgcttgtgg gcactggctt 660 ggactttagc ggggagggaa gccaggggat tttgaagggt ggacattagg gtagggtgag 720 gtcaacctaa tactgacttg tcagtatctc cagctctgat tacctttgaa gtgttcagaa 780 gagacattgt cttctactgt tctgccaggt tcttcttgag ctttgggcct cagttgccct 840 ggcagaaaaa tggattcaac ttggcctttc tgaaggcaag actgggattg gatcacttct 900 taaacttcca gttaagaatc taggtccgcc ctcaagccca tactgaccat gcctcatcca 960 gagctcctct gaagccaggg ggctaacgga tgttgtgtgg agtcctggct ggaggtcctc 1020 ccccagtggc cttcctccct tcctttcaca gccggtctct ctgccaggaa atgggggaag 1080 gaactagaac cacctgcacc ttgagatgtt tctgtaaatg ggtacttgtg atcacactac 1140 gggaatctct gtggtatata cctggggcca ttctaggctc tttcaagtga cttttggaaa 1200 tcaacctttt ttatttgggg gggaggatgg ggaaaagagc tgagagttta tgctgaaatg 1260 gatttataga atatttgtaa atctattttt agtgtttgtt cgttttttta actgttcatt 1320 cctttgtgca gagtgtatat ctctgcctgg gcaagagtgt ggaggtgccg aggtgtcttc 1380 attctctcgc acatttccac agcacctgct aagtttgtat ttaatggttt ttgtttttgt 1440 ttttgtttgt ttcttgaaaa tgagagaaga gccggagaga tgatttttat taattttttt 1500 tttttttttt tttttttact atttatagct ttagataggg cctcccttcc cctcttcttt 1560 ctttgttctc tttcattaaa ccccttcccc agtttttttt ttatacttta aaccccgctc 1620 ctcatggcct tggccctttc tgaagctgct tcctcttata aaatagcttt tgccgaaaca 1680 tagttttttt ttagcagatc ccaaaatata atgaagggga tggtgggata tttgtgtctg 1740 tgttcttata atatattatt attcttcctt ggttctagaa aaatagataa atatattttt 1800 ttcaggaaat agtgtggtgt ttccagtttg atgttgctgg gtggttgagt gagtgaattt 1860 tcatgtggct gggtgggttt ttgccttttt ctcttgccct gttcctggtg ccttctgatg 1920 gggctggaat agttgaggtg gatggttcta ccctttctgc cttctgtttg ggacccagct 1980 ggtgttcttt ggtttgcttt cttcaggctc tagggctgtg ctatccaata cagtaaccac 2040 atgcggctgt ttaaagttaa gccaattaaa atcacataag attaaaaatt ccttcctcag 2100 ttgcactaac cacgtttcta gaggcgtcac tgtatgtagt tcatggctac tgtactgaca 2160 gcgagagcat gtccatctgt tggacagcac tattctagag aactaaactg gcttaacgag 2220 tcacagcctc agctgtgctg ggacgaccct tgtctccctg ggtagggggg ggggaatggg 2280 ggagggctga tgaggcccca gctggggcct gttgtctggg accctccctc tcctgagagg 2340 ggaggcctgg tggcttagcc tgggcaggtc gtgtctcctc ctgaccccag tggctgcggt 2400 gaggggaacc accctccctt gctgcaccag tggccattag ctcccgtcac cactgcaacc 2460 cagggtccca gctggctggg tcctcttctg cccccagtgc ccttcccctt gggctgtgtt 2520 ggagtgagca cctcctctgt aggcacctct cacactgttg tctgttactg attttttttg 2580 ataaaaagat aataaaacct ggtactttct aaa 2613 <210> 267 <211> 4260 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(4260) <223> TAGLN mRNA <400> 267 cgaggagcga gccagtgggg gaggctgaca tcaccacggc ggcagccctt taaacccctc 60 acccagccag cgccccatcc tgtctgtccg aacccagaca caagtcttca ctccttcctg 120 cgagccctga ggaagccttg tgagtgcatt ggctggggct tggagggaag ttgggctgga 180 gctggacagg agcagtgggt gcatttcagg caggctctcc tgaggtccca ggcgccagct 240 ccagctccct ggctagggaa acccaccctc tcagtcagca tgggggccca agctccaggc 300 agggtgggct ggatcactag cgtcctggat ctctctcaga ctgggcagcc ccgggctcat 360 tgaaatgccc cggatgactt ggctagtgca gaggaattga tggaaaccac cggggtgaga 420 gggaggctcc ccatctcagc cagccacatc cacaaggtgt gtgtaagggt gcaggcgccg 480 gccggttagg ccaaggctct actgtctgtt gcccctccag gagaacttcc aaggagcttt 540 ccccagacat ggccaacaag ggtccttcct atggcatgag ccgcgaagtg cagtccaaaa 600 tcgagaagaa gtatgacgag gagctggagg agcggctggt ggagtggatc atagtgcagt 660 gtggccctga tgtgggccgc ccagaccgtg ggcgcttggg cttccaggtc tggctgaaga 720 atggcgtgat tctgagcaag ctggtgaaca gcctgtaccc tgatggctcc aagccggtga 780 aggtgcccga gaacccaccc tccatggtct tcaagcagat ggagcaggtg gctcagttcc 840 tgaaggcggc tgaggactat ggggtcatca agactgacat gttccagact gttgacctct 900 ttgaaggcaa agacatggca gcagtgcaga ggaccctgat ggctttgggc agcttggcag 960 tgaccaagaa tgatgggcac taccgtggag atcccaactg gtttatgaag aaagcgcagg 1020 agcataagag ggaattcaca gagagccagc tgcaggaggg aaagcatgtc attggccttc 1080 agatgggcag caacagaggg gcctcccagg ccggcatgac aggctacgga cgacctcggc 1140 agatcatcag ttagagcgga gagggctagc cctgagcccg gccctccccc agctccttgg 1200 ctgcagccat cccgcttagc ctgcctcacc cacacccgtg tggtaccttc agccctggcc 1260 aagctttgag gctctgtcac tgagcaatgg taactgcacc tgggcagctc ctccctgtgc 1320 ccccagcctc agcccaactt cttacccgaa agcatcactg ccttggcccc tccctcccgg 1380 ctgcccccat cacctctact gtctcctccc tgggctaagc aggggagaag cgggctgggg 1440 gtagcctgga tgtgggccaa gtccactgtc ctccttggcg gcaaaagccc attgaagaag 1500 aaccagccca gcctgccccc tatcttgtcc tggaatattt ttggggttgg aactcaaaaa 1560 aaaaaaaaaa aaatcaatct tttctcaggc ctggctggca gagtttgatt tgccctggtc 1620 acttttgtta tggtttcaga tctgcgcagg ggacaggcag gcatctcggg cttgtatgtg 1680 ttcctggctg ccgtcctctg aaggaccctt catgtgccaa gattccagga cagtcagatt 1740 ctttcagagg aaacaggcca tagaacagga gagtgaatct tggggaccga agggaaaaag 1800 gagccactca gcagcatgca gtggctttgg ggagacagag gaaaggagag attgcgagtg 1860 gcagaattgt ttggaaggtt tttattttgg aaaagctgtg cagaaaaaaa ttcaagaaaa 1920 tgttgctgtg aaaagagaaa aacaaatctt aagcattaaa aaaaattcaa ccaactagct 1980 cagaagaggg gagaaggcca aggttgagag aagagtcaca gcctgtcagg cagatagctg 2040 gcctccggcg ggaaggccat ttccctgagc acttgcagag gaagacaggg tggtggcagg 2100 actggagtgg cagtggctcc caaggctctc tcctccaaca tgtgcatctg ccatctgctc 2160 tgcagtcctg ccgcaggatt ccctagtgaa gcagctcagg cctgggggag ccgtgtgtat 2220 cccagctgtg ccggcagcat cataccaatc gtgggggtgg tgaaggagcc aggggttcat 2280 tcatggttgg tttctgatca ggcatcttgg gaatggataa tggaggcagc cgctttcagg 2340 acaggcatgt ccaggggctc ctcccagcct ctaccccgaa gtcctcttcc caagtgaccc 2400 cagtgatgtt tccattgaga tgcgctcctg gctatggcag gcaccttctc aacttatatg 2460 tgggaagggg tcccccatgc ttgggggacc taggcagctg gcttggccca agagagatga 2520 ggatggaggc caaaccaaag gggggcgcca atcccctgtc caacaccttc tcaccaaaag 2580 ctcccgtttg gctggaggca gaccctgtgg ctctgaccag acttctctgg cagcaatcct 2640 ccaccatttg tatcttaaga aggccctcac cctctttgag tggagtcaga ggatgcctca 2700 gattccagat gtaagcatca gaactgcttt ctgtcaagag ctccctaatt ttgggaaaga 2760 agagcctgtc ccacactgtc aggccctgag gtcagcagat ctgctcctcc ttcccgtgcg 2820 gtacgtctag gtgctgatga gggcagtcca gggcgctctt gttctgggac aggctccagt 2880 ccccttgctc cagcaggtct ggggcaagga ggtcagaggt ggtgggaggg cccctgctct 2940 ctgtttccac ttcgtctgga tccttgctgc tgcaaagtgg cactgattct agctctgtcc 3000 cttcctcctt ggctttccgg ctccgatggg gccagtggca gggtccactc ctacaaactt 3060 gattggaagc cacattcctc tggctcaaat atacttccag catgtagtaa acagtccaga 3120 agacggtgaa acagcctacc agcaccaggg tctggggccg aggcaagcac ctacgtgagg 3180 cactgtttcc cgaagcctac agcctttctc agcccaggac aatgagctca gaaagtcttt 3240 ttccttctag ggactgcctt tttcacccaa actgttccct ctgccccctc ccccgacaag 3300 gcctgtcctg taagagttag gctagcaggg taggagcaat gctatgaaac cactgctggg 3360 acccaggtct tcccagtcct tcaccccgca ggtcaccctg agaaacacac taagaactcc 3420 atcccccaga caggacagtc ccatctaccc gcagcttgag tcttggccct agtaccttga 3480 gggtgttggg ggtgatggtg taaccatctt cctcaggaat tttcagcccc ggtgggcagg 3540 gcagggcgaa gtcatcgtgc aggtattttc cactcatggc actctctaac agcctgtgga 3600 gaagaaaaga ggtgaggatg ccccactgac tatggttcct ataccatctg ccctcaccca 3660 ttttcctgcc ttacaggtga agacagggaa gccccacagc aaaaaggaga ggcccagact 3720 gtgagttccc agcccggggc tccatctacc ggcttgacgc tggaactggg aagcacagct 3780 ggggttcaga gggcgatggg ctccctaggc ggcccttccc ctgtgactgg ccttccctct 3840 gacacatgcg gctttaccca cctttgtctg tccctgatgt ctactgcact ccacacagag 3900 ccatataggg tcagctgcca ttgccggagg atgccgacct ggaatgactc atcccctagg 3960 gcagcaaggg gcagctcgtg agccacgccc ctctgtcagc catgccagac agcagaggcc 4020 ctgcccgccc tgccacccaa aggggctcag gccacatggt ctgctccagg agctgcctca 4080 ctgtgtccca ctgaccccag gttctgcaga agggcctcac tgggtgccct tagggatgga 4140 aagggttgaa aggctgtact ccaaagcaga gtcttgcttt tctctcccgt attttggggg 4200 ttcagctggg attagaaaaa aatgtctttc caccaaatta aagaaagctt tgaaaaccac 4260 4260 <210> 268 <211> 2444 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2444) <223> TFPI2 mRNA <400> 268 attactgaca caaacgctcc ctcagggcgt ccccgtctgg actacaggag aaagtttggg 60 aggcaggttc aacttttcaa cttggcgggg aattcctctc cctcttacac agtttgcagc 120 gcgggggcgg cggggtgaca gtccccgtgc atgaatcagc cacccctcag gctccgcccc 180 ggcgggggtc ggccggacgc tcgccccgca taaagcgggc acccgggccg cctggagcag 240 aaagccgcgc acctcctccc gccaggcgct ttctcggacg ccttgcccag cgggccgccc 300 gaccccctgc accatggacc ccgctcgccc cctggggctg tcgattctgc tgcttttcct 360 gacggaggct gcactgggcg atgctgctca ggagccaaca ggaaataacg cggagatctg 420 tctcctgccc ctagactacg gaccctgccg ggccctactt ctccgttact actacgacag 480 gtacacgcag agctgccgcc agttcctgta cgggggctgc gagggcaacg ccaacaattt 540 ctacacctgg gaggcttgcg acgatgcttg ctggaggata gaaaaagttc ccaaagtttg 600 ccggctgcaa gtgagtgtgg acgaccagtg tgaggggtcc acagaaaagt atttctttaa 660 tctaagttcc atgacatgtg aaaaattctt ttccggtggg tgtcaccgga accggattga 720 gaacaggttt ccagatgaag ctacttgtat gggcttctgc gcaccaaaga aaattccatc 780 attttgctac agtccaaaag atgagggact gtgctctgcc aatgtgactc gctattattt 840 taatccaaga tacagaacct gtgatgcttt cacctatact ggctgtggag ggaatgacaa 900 taactttgtt agcagggagg attgcaaacg tgcatgtgca aaagctttga aaaagaaaaa 960 gaagatgcca aagcttcgct ttgccagtag aatccggaaa attcggaaga agcaatttta 1020 aacattctta atatgtcatc ttgtttgtct ttatggctta tttgccttta tggttgtatc 1080 tgaagaataa tatgacagca tgaggaaaca aatcattggt gatttattca ccagttttta 1140 ttaatacaag tcacttttta aaaaatttgg atttttttat atataactag ctgctattca 1200 aatgtgagtc taccattttt aatttatggt tcaactgttt gtgagactga attcttgcaa 1260 tgcataagat ataaaagcaa atatgactca ctcatttctt ggggtcgtat tcctgatttc 1320 agaagaggat cataactgaa acaacataag acaatataat catgtgcttt taacatattt 1380 gagaataaaa aggactagca aataaaactc attttgcatt taaaagttgg attatatttt 1440 agtcccaaga agacaaagtc gcagattaac aacactttaa aaatattact cccattttat 1500 tgtgttagat tgcagtacaa tgaatgaata aggggattta tttaaaagat cttaactttc 1560 ttgactgatt taaaaagcta atcaatttat taaagccaga aatgttctcc tctgggaaag 1620 caatttctat ctatttatct accaatcccc actcacatgt atatgtttgt gtttacatag 1680 agatagatgg ttttaagggt tttcctattg ttaaattatt tcctaagaca ttgtgggttg 1740 gagaccacta aacttataaa aaaccaagga aagtaaagtt tttcaaatgt ttatactgtt 1800 taaggtgttt atttatataa accatgcatg agaaaccatg cataaattta ataatttaaa 1860 tttcaccagt aaattatcat tgattaaata tggtcatacc aatgaaatag gttttttctt 1920 tctctgtaat aaaacaattt ttctaaattc ttatgttttc atagcaagat taacatattt 1980 aattacaaat taaatatgca aaatgacaaa tgcgtttacc ttttgcttga acaatctttc 2040 atttaaaaat ttatcccagt tattttgaca aataggtata tgcctgagaa ctttgaatga 2100 tgctgaaagc tagaagcaaa ccaggtactc ttcagtcagg gactggttga agattttatg 2160 gatgaggagt tagcaaaata tctatatatg catatcttct gactcccagg atacataaga 2220 aacacagggc ctagaacagt atgaataaac acacatatac acaaacatca cagaagatac 2280 taaagatatt aaaaatgttt acctatagag gtttggagag aacagagggg tggacagttg 2340 tggagataat atttgtgtaa atataactgt gatatagttt ttatcttgga ccatgtaaat 2400 atttgacata attaataatc aaaattaaat aaaaaagaaa aagc 2444 <210> 269 <211> 2741 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(2741) <223> TGFB1 mRNA <400> 269 acctccctcc gcggagcagc cagacagcga gggccccggc cgggggcagg ggggacgccc 60 cgtccggggc acccccccgg ctctgagccg cccgcggggc cggcctcggc ccggagcgga 120 ggaaggagtc gccgaggagc agcctgaggc cccagagtct gagacgagcc gccgccgccc 180 ccgccactgc ggggaggagg gggaggagga gcgggaggag ggacgagctg gtcgggagaa 240 gaggaaaaaa acttttgaga cttttccgtt gccgctggga gccggaggcg cggggacctc 300 ttggcgcgac gctgccccgc gaggaggcag gacttgggga ccccagaccg cctccctttg 360 ccgccgggga cgcttgctcc ctccctgccc cctacacggc gtccctcagg cgcccccatt 420 ccggaccagc cctcgggagt cgccgacccg gcctcccgca aagacttttc cccagacctc 480 gggcgcaccc cctgcacgcc gccttcatcc ccggcctgtc tcctgagccc ccgcgcatcc 540 tagacccttt ctcctccagg agacggatct ctctccgacc tgccacagat cccctattca 600 agaccaccca ccttctggta ccagatcgcg cccatctagg ttatttccgt gggatactga 660 gacacccccg gtccaagcct cccctccacc actgcgccct tctccctgag gacctcagct 720 ttccctcgag gccctcctac cttttgccgg gagaccccca gcccctgcag gggcggggcc 780 tccccaccac accagccctg ttcgcgctct cggcagtgcc ggggggcgcc gcctccccca 840 tgccgccctc cgggctgcgg ctgctgccgc tgctgctacc gctgctgtgg ctactggtgc 900 tgacgcctgg ccggccggcc gcgggactat ccacctgcaa gactatcgac atggagctgg 960 tgaagcggaa gcgcatcgag gccatccgcg gccagatcct gtccaagctg cggctcgcca 1020 gccccccgag ccagggggag gtgccgcccg gcccgctgcc cgaggccgtg ctcgccctgt 1080 acaacagcac ccgcgaccgg gtggccgggg agagtgcaga accggagccc gagcctgagg 1140 ccgactacta cgccaaggag gtcacccgcg tgctaatggt ggaaacccac aacgaaatct 1200 atgacaagtt caagcagagt acacacagca tatatatgtt cttcaacaca tcagagctcc 1260 gagaagcggt acctgaaccc gtgttgctct cccgggcaga gctgcgtctg ctgaggctca 1320 agttaaaagt ggagcagcac gtggagctgt accagaaata cagcaacaat tcctggcgat 1380 acctcagcaa ccggctgctg gcacccagcg actcgccaga gtggttatct tttgatgtca 1440 ccggagttgt gcggcagtgg ttgagccgtg gaggggaaat tgagggcttt cgccttagcg 1500 cccactgctc ctgtgacagc agggataaca cactgcaagt ggacatcaac gggttcacta 1560 ccggccgccg aggtgacctg gccaccattc atggcatgaa ccggcctttc ctgcttctca 1620 tggccacccc gctggagagg gcccagcatc tgcaaagctc ccggcaccgc cgagccctgg 1680 acaccaacta ttgcttcagc tccacggaga agaactgctg cgtgcggcag ctgtacattg 1740 acttccgcaa ggacctcggc tggaagtgga tccacgagcc caagggctac catgccaact 1800 tctgcctcgg gccctgcccc tacatttgga gcctggacac gcagtacagc aaggtcctgg 1860 ccctgtacaa ccagcataac ccgggcgcct cggcggcgcc gtgctgcgtg ccgcaggcgc 1920 tggagccgct gcccatcgtg tactacgtgg gccgcaagcc caaggtggag cagctgtcca 1980 acatgatcgt gcgctcctgc aagtgcagct gaggtcccgc cccgccccgc cccgccccgg 2040 caggcccggc cccaccccgc cccgcccccg ctgccttgcc catgggggct gtatttaagg 2100 acacccgtgc cccaagccca cctggggccc cattaaagat ggagagagga ctgcggatct 2160 ctgtgtcatt gggcgcctgc ctggggtctc catccctgac gttcccccac tcccactccc 2220 tctctctccc tctctgcctc ctcctgcctg tctgcactat tcctttgccc ggcatcaagg 2280 cacaggggac cagtggggaa cactactgta gttagatcta tttattgagc accttgggca 2340 ctgttgaagt gccttacatt aatgaactca ttcagtcacc atagcaacac tctgagatgc 2400 agggactctg ataacaccca ttttaaaggt gaggaaacaa gcccagagag gttaagggag 2460 gagttcctgc ccaccaggaa cctgctttag tgggggatag tgaagaagac aataaaagat 2520 agtagttcag gccaggcggg gtggctcacg cctgtaatcc tagcactttt gggaggcaga 2580 gatgggagga ttacttgaat ccaggcattt gagaccagcc tgggtaacat agtgagaccc 2640 tatctctaca aaacactttt aaaaaatgta cacctgtggt cccagctact ctggaggcta 2700 aggtgggagg atcacttgat cctgggaggt caaggctgca g 2741 <210> 270 <211> 6339 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6339) <223> TGFBR3 mRNA <400> 270 aatcgagggt ttcggggacg ccgagcggca ctttcctctt cccagcgagt gaaggagggc 60 agtcggcggc tctcgcgccc cggccacttt ccctgcgcga ttcccggagc tccctgcagg 120 aggtgagagt ccccagcggg tccggatggc gtagttttgc cgcggcgcag cagctgccgg 180 agctcgccgc cgccgagcgc tgggcgggga aacttgccgc cgctttcctc caacttgctg 240 cgggtggatc tccgctggac acaccgcctc cgaggcagtt tgaaaattgc aaggagggac 300 tttaagacta cttctgattt gcaaagattg tctgtgctct gagcaggctg aagtgactgg 360 acgagacgca ctgttggaga aataaaaatg acttcccatt atgtgattgc catctttgcc 420 ctgatgagct cctgtttagc cactgcaggt ccagagcctg gtgcactgtg tgaactgtca 480 cctgtcagtg cctcccatcc tgtccaggcc ttgatggaga gcttcactgt tttgtcaggc 540 tgtgccagca gaggcacaac tgggctgcca caggaggtgc atgtcctgaa tctccgcact 600 gcaggccagg ggcctggcca gctacagaga gaggtcacac ttcacctgaa tcccatctcc 660 tcagtccaca tccaccacaa gtctgttgtg ttcctgctca actccccaca ccccctggtg 720 tggcatctga agacagagag acttgccact ggggtctcca gactgttttt ggtgtctgag 780 ggttctgtgg tccagttttc atcagcaaac ttctccttga cagcagaaac agaagaaagg 840 aacttccccc atggaaatga acatctgtta aattgggccc gaaaagagta tggagcagtt 900 acttcattca ccgaactcaa gatagcaaga aacatttata ttaaagtggg ggaagatcaa 960 gtgttccctc caaagtgcaa catagggaag aattttctct cactcaatta ccttgctgag 1020 taccttcaac ccaaagcagc agaagggtgt gtgatgtcca gccagcccca gaatgaggaa 1080 gtacacatca tcgagctaat cacccccaac tctaacccct acagtgcttt ccaggtggat 1140 ataacaattg atataagacc ttctcaagag gatcttgaag tggtcaaaaa tctcatcctg 1200 atcttgaagt gcaaaaagtc tgtcaactgg gtgatcaaat cttttgatgt taagggaagc 1260 ctgaaaatta ttgctcctaa cagtattggc tttggaaaag agagtgaaag atctatgaca 1320 atgaccaaat caataagaga tgacattcct tcaacccaag ggaatctggt gaagtgggct 1380 ttggacaatg gctatagtcc aataacttca tacacaatgg ctcctgtggc taatagattt 1440 catcttcggc ttgaaaataa tgcagaggag atgggagatg aggaagtcca cactattcct 1500 cctgagctac ggatcctgct ggaccctggt gccctgcctg ccctgcagaa cccgcccatc 1560 cggggagggg aaggccaaaa tggaggcctt ccgtttcctt tcccagatat ttccaggaga 1620 gtctggaatg aagagggaga agatgggctc cctcggccaa aggaccctgt cattcccagc 1680 atacaactgt ttcctggtct cagagagcca gaagaggtgc aagggagcgt ggatattgcc 1740 ctgtctgtca aatgtgacaa tgagaagatg atcgtggctg tagaaaaaga ttcttttcag 1800 gccagtggct actcggggat ggacgtcacc ctgttggatc ctacctgcaa ggccaagatg 1860 aatggcacac actttgtttt ggagtctcct ctgaatggct gcggtactcg gccccggtgg 1920 tcagcccttg atggtgtggt ctactataac tccattgtga tacaggttcc agcccttggg 1980 gacagtagtg gttggccaga tggttatgaa gatctggagt caggtgataa tggatttccg 2040 ggagatatgg atgaaggaga tgcttccctg ttcacccgac ctgaaatcgt ggtgtttaat 2100 tgcagccttc agcaggtgag gaaccccagc agcttccagg aacagcccca cggaaacatc 2160 accttcaaca tggagctata caacactgac ctctttttgg tgccctccca gggcgtcttc 2220 tctgtgccag agaatggaca cgtttatgtt gaggtatctg ttactaaggc tgaacaagaa 2280 ctgggatttg ccatccaaac gtgctttatc tctccatatt cgaaccctga taggatgtct 2340 cattacacca ttattgagaa tatttgtcct aaagatgaat ctgtgaaatt ctacagtccc 2400 aagagagtgc actttcctat cccgcaagct gacatggata agaagcgatt cagctttgtc 2460 ttcaagcctg tcttcaacac ctcactgctc tttctacagt gtgagctgac gctgtgtacg 2520 aagatggaga agcaccccca gaagttgcct aagtgtgtgc ctcctgacga agcctgcacc 2580 tcgctggacg cctcgataat ctgggccatg atgcagaata agaagacgtt cactaagccc 2640 cttgctgtga tccaccatga agcagaatct aaagaaaaag gtccaagcat gaaggaacca 2700 aatccaattt ctccaccaat tttccatggt ctggacaccc taaccgtgat gggcattgcg 2760 tttgcagcct ttgtgatcgg agcactcctg acgggggcct tgtggtacat ctattctcac 2820 acaggggaga cagcaggaag gcagcaagtc cccacctccc cgccagcctc ggaaaacagc 2880 agtgctgccc acagcatcgg cagcacgcag agcacgcctt gctccagcag cagcacggcc 2940 tagcccaacc cagcccaacc cggcccaacc cagcccagcc cagctcagct cagctactgc 3000 caagggcagg accaatggct gagcctcgtg tccagactca gagggctgga ttttggttcc 3060 cttgtaaaga cagagtgaat ttcagtataa agatcacccg ttgtattcac cccacaccca 3120 gggctagtat aaacatgacc ctgggcttct gtaccacact agaattcatg tgagaaagct 3180 aaaatggtgg tcttctccac cagcccctca caggcttggg ggttttcaat gtgaaacaca 3240 tgccagtttt taaaatgctg ctttgtccag gtgagaacat ccataatttg gggccctgag 3300 ttttacccag actcaaggag ttggtaaagg gttaatagcc agatagtaga accagtgagg 3360 agatgcggcc aaagattctt tatatctgaa ccaagatgta aaacaagaaa tgctttgagg 3420 ctttctaagc gatcctcctg tctaatttgc acctttgtct ggatgcacac ttctgacctt 3480 gctgccacaa cctgtggggt ctgatgtgtc ccttgatggg tgctgccctc agggactgca 3540 ccctgacaag tgttaaggca acattccttt cttgtgccct gggccaaaac caatgctgat 3600 gaccttatca gcttcctgtt tcttcccata cttgcataca ccactgcaaa atgtcttaat 3660 gcaaattttg tatttcttac aggcctacag aaattgaaaa tgaccaaaat caggaaccac 3720 agatttgtgc ccattcctaa tattttgttc tgcaaattaa tgtataattt gaggtgaaat 3780 tcagttataa agtcaaggac gaatttgcac agtgatatat ttctatgtgt atgcaagtac 3840 aagtatataa tatgtcacct ggcacattca ttttctcagt tgaagaagag aaaatttgaa 3900 aatgtcctta tgcttttaga gttgcaactt aagtatattt ggtagggtga gtgtttccac 3960 tcaaaatatg tcaacttaaa aaaaaatagg ccctttcata aaaaccaaac tgtagcaaga 4020 tgcaaatgca tggcaaatcc tgtcggtctc cagttggtta tctgaatagt gtcaccaatt 4080 ccaccaagac agtgctgaga ttggaaaagg gcactcattt ggattgcctt acttctcttg 4140 ccttaaatat atcccatata tttaatatgt caaaaagggc ttgaggtgaa tttcattaaa 4200 tggaataata tgatgccact ttgcagctaa aataagctca gtgatacctc cttgttaaaa 4260 aaaaaaaaaa aaaaaaagaa tgccaggggg gaattatcat gctaaattat tttactgctg 4320 aagatagctt cattgcaaat tattcttttt ccagaatttc ccccaaacaa cttagaattc 4380 cataagtaga acaagataga ttctaccccc aaaatattca taagcaaatc ccactgccct 4440 taaaataagg aagttatgcc tggttgtctg tgaatggaac ctcagtaggt aatcctgatg 4500 aagcttaaaa ccttagggca gtgtctacat gggaaacaag tatgtggaaa ttgacaatca 4560 tttttaccaa atcgttgagt aataatatga cttacctgat agatatacac attcaataag 4620 gaacattttt ttttttcaat aaggaacatt ttaactaaaa cattacttta gggctgagat 4680 ttccaggcta tctacattga tctactgaaa aatttctaga tttccatata caaacgaaga 4740 agacatgagt ttagagaatt tttttccttt aatttttttt taacagaagg gtatcagagt 4800 ggaggaccta gattacgcta cctgtgtttg aaaatattgc gctttgccta accttcggtg 4860 gaatgtattg tttcagcata ttctatgtat aaaaaagttt aaagatgtct tcaaagaaga 4920 ctagagtctt taagtcactt atagctatat tttactacaa aatttgtgta taaagatata 4980 tttaagtgtt ttagataaat ttaagttact ccatatgaaa tgtttaattt cagctactgt 5040 gaattctttc gatcagtcct ttgctttttt aaaaaatctt ttccatcgtg ttaaaaagaa 5100 aattagctat taggagatat taaaagattg atgtcttaga aggacagggt taaaaccttc 5160 tgtaatatat ttaaatatat atttttaaga gagatgctac attgccaatg attttataaa 5220 taatttaaaa ttaatttaca aatttataga tgcaaaccaa aagatctttt taaaagagag 5280 agagaggaaa aaaatcacct tttatttgtt tgggtctcat tgtcagaatt attattcaga 5340 tcaagaaatc tgtgtcgata aaacctaatc tcatattgga gagtgaatgt cgttaagtat 5400 ttctgaaatg tttctaaaaa atgaacatga aaaaaataag gtattttctc cctagcttct 5460 cattacagta tttctaattg cttcacactt tacagtttta atacaaagta caagctctac 5520 ttttataacg tgtactacaa gtttctttaa aagtattgtt gtatttcagc tgaactcttg 5580 tatctgcagt cttttgttat ttctgcaggc tacaccctta atttgcagag gccattttgt 5640 tgtttgtttg atgctgaagc tgttgttaaa atgccccaaa ctccaaggca gattgtctgt 5700 ataatacgct atagcttttc accatgtggt gtttaccagc tgttactctg tattttaaaa 5760 agccagagat ttcttctgtc taaactgttt ctatagcatt ttctaaacaa aaaaaatggt 5820 ttttttcttt gccttgtaat aagattgtaa atccatttcc tgcttgtgtt cttagtgggc 5880 atgattgtga gtgtgtgtgg ggtgctcaca cgcgtgccag tctttttgta ctgtaactac 5940 ctcatggttt gaatgatgat tgtactgctg gttgtgttaa cagagcacat tttgttgggt 6000 gagtcctatg tgattttttt catgtttgtt ttatctgggg gttgttcatg aaactgacag 6060 atgtttttct aaaaaggact attatcagtt tccaaataca atacttctct cttctggttt 6120 ttcctgaatg agcctgattt tgttgctggt tttcatcatc tatgagggta aaacgagtac 6180 ccttaaaatc cctgtggcca gtttgaacac ccctgttgta ttcttttctc tgttcagtgt 6240 gtcagctatt ttgtgaagat gcttagatgt atagttttga taaccacagt tttaaatctt 6300 ttatctgtgc ataataaaaa gatatatatc agttattaa 6339 <210> 271 <211> 769 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(769) <223> TIMP1 mRNA <400> 271 gccatcgccg cagatccagc gcccagagag acaccagaga acccaccatg gccccctttg 60 agcccctggc ttctggcatc ctgttgttgc tgtggctgat agcccccagc agggcctgca 120 cctgtgtccc accccaccca cagacggcct tctgcaattc cgacctcgtc atcagggcca 180 agttcgtggg gacaccagaa gtcaaccaga ccaccttata ccagcgttat gagatcaaga 240 tgaccaagat gtataaaggg ttccaagcct taggggatgc cgctgacatc cggttcgtct 300 acacccccgc catggagagt gtctgcggat acttccacag gtcccacaac cgcagcgagg 360 agtttctcat tgctggaaaa ctgcaggatg gactcttgca catcactacc tgcagttttg 420 tggctccctg gaacagcctg agcttagctc agcgccgggg cttcaccaag acctacactg 480 ttggctgtga ggaatgcaca gtgtttccct gtttatccat cccctgcaaa ctgcagagtg 540 gcactcattg cttgtggacg gaccagctcc tccaaggctc tgaaaagggc ttccagtccc 600 gtcaccttgc ctgcctgcct cgggagccag ggctgtgcac ctggcagtcc ctgcggtccc 660 agatagcctg aatcctgccc ggagtggaag ctgaagcctg cacagtgtcc accctgttcc 720 cactcccatc tttcttccgg acaatgaaat aaagagttac cacccagca 769 <210> 272 <211> 1876 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1876) <223> TMEM158 mRNA <400> 272 ggggaatcct gctctgggat agcacccggc cccgcagagc agcgcggcag cccaagggcc 60 ccggcgccgg gggcggcggg gaaccccaaa cgcaaccggg tctggaggga tccccgcgcc 120 gagccagccg ccgtcaccgc ctccgcgccg cccctgcggg cttggcaggc gcccggcgcg 180 cccgcactgc gcccggccgc cggctcccgc ggtcccaccg tgagctcgcc ggcccgtcgc 240 ccgctcgcca tgcaaccgcc gccggcctcg cgcgcgtagg cgcccgccgc aggccatgct 300 gcccctgctc gccgcgctcc tggccgccgc ctgcccgctg ccgcccgtcc gcggcggggc 360 cgcggacgcg cccggcctcc tcggggtgcc ctccaatgct tcagtcaacg cgtcctccgc 420 ggacgagccc atcgccccgc ggctgctggc ctcggcggcc cccgggcccc ccgagcgccc 480 gggcccggag gaggcggcgg cggcggcggc gccgtgcaac atcagcgtgc agcggcagat 540 gctgagctcg ctgctcgtgc gctggggccg cccgcggggc ttccagtgcg acctactgct 600 cttctccacc aacgcgcacg gccgcgcttt cttcgccgcc gccttccacc gcgtcgggcc 660 gccgctgctc atcgagcacc tggggctggc ggcgggcggc gcgcagcagg acctgcgcct 720 ctgcgtgggc tgcggctggg tgcgcggtcg ccgcaccggc cgcctccggc ccgccgccgc 780 ccccagcgcc gccgccgcca ccgccggggc gcccaccgcg ctgccagcct accccgcggc 840 cgagccgccc gggccgctgt ggctgcaggg cgagccgctg catttctgct gcctagactt 900 cagcctggag gagctgcagg gcgagccggg ctggcggctg aaccgtaagc ccattgagtc 960 cacgctggtg gcctgcttca tgaccctggt catcgtggtg tggagcgtgg ccgccctcat 1020 ctggccggtg cccatcatcg ccggcttcct gcccaacggc atggaacagc gccggaccac 1080 cgccagcacc accgcagcca cccccgccgc agtgcccgca gggaccaccg cagccgccgc 1140 cgccgccgcc gctgccgccg ccgccgcggc cgtcacttcg ggggtggcga ccaagtgacc 1200 cgctccgctc ctccctgtgt ccgtcctgtg tccgcgcgcg cgggtgcctt tcccgccgga 1260 gactcggccg gtgtgcttcg tgctgtagtt atcgttagtt cctcttcccg agatggggcc 1320 gccgagagac cccagcgcct ttgaaaagca aggtttgtgc tgcgcttcca gttccgaaaa 1380 gcagatgttt aagcccttgg actgagggtg ggatcgcagc tccgaagacg gagaggaggg 1440 aaatggggcc ctttcccctc tattgcatcc ccctgcccga ctccttcccc gcacccacgt 1500 gccctagatt catggcagaa aatgaccaaa tcctgtgtat ttgttttata tatttaataa 1560 ctgttttaaa tgaaagtttt agtaaaaaaa atacaaaaca aaaagattaa attgctattg 1620 ctgtagtaag agaagctctt tgtatctgaa catagttgta tttgaaattt gtggtttttt 1680 aatttattta aaattggggg gagggcatgg gaaggattta acaccgatat attgttaccg 1740 ctgaaaatga actttatgaa ccttttccaa gttgatctat ccagtgacgt ggcctggtgg 1800 gcgtttcttc ttgtacttat gtggtttttt ggcttttaat acagacattt tcctccagaa 1860 aaaaaaaaaa aaaaaa 1876 <210> 273 <211> 1422 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1422) <223> TNFAIP6 mRNA <400> 273 agtcacattt cagccactgc tctgagaatt tgtgagcagc ccctaacagg ctgttacttc 60 actacaactg acgatatgat catcttaatt tacttatttc tcttgctatg ggaagacact 120 caaggatggg gattcaagga tggaattttt cataactcca tatggcttga acgagcagcc 180 ggtgtgtacc acagagaagc acggtctggc aaatacaagc tcacctacgc agaagctaag 240 gcggtgtgtg aatttgaagg cggccatctc gcaacttaca agcagctaga ggcagccaga 300 aaaattggat ttcatgtctg tgctgctgga tggatggcta agggcagagt tggatacccc 360 attgtgaagc cagggcccaa ctgtggattt ggaaaaactg gcattattga ttatggaatc 420 cgtctcaata ggagtgaaag atgggatgcc tattgctaca acccacacgc aaaggagtgt 480 ggtggcgtct ttacagatcc aaagcaaatt tttaaatctc caggcttccc aaatgagtac 540 gaagataacc aaatctgcta ctggcacatt agactcaagt atggtcagcg tattcacctg 600 agttttttag attttgacct tgaagatgac ccaggttgct tggctgatta tgttgaaata 660 tatgacagtt acgatgatgt ccatggcttt gtgggaagat actgtggaga tgagcttcca 720 gatgacatca tcagtacagg aaatgtcatg accttgaagt ttctaagtga tgcttcagtg 780 acagctggag gtttccaaat caaatatgtt gcaatggatc ctgtatccaa atccagtcaa 840 ggaaaaaata caagtactac ttctactgga aataaaaact ttttagctgg aagatttagc 900 cacttataaa aaaaaaaaaa aggatgatca aaacacacag tgtttatgtt ggaatctttt 960 ggaactcctt tgatctcact gttattatta acatttattt attatttttc taaatgtgaa 1020 agcaatacat aatttaggga aaattggaaa atataggaaa ctttaaacga gaaaatgaaa 1080 cctctcataa tcccactgca tagaaataac aagcgttaac attttcatat ttttttcttt 1140 cagtcatttt tctatttgtg gtatatgtat atatgtacct atatgtattt gcatttgaaa 1200 ttttggaatc ctgctctatg tacagttttg tattatactt tttaaatctt gaactttata 1260 aacattttct gaaatcattg attattctac aaaaacatga ttttaaacag ctgtaaaata 1320 ttctatgata tgaatgtttt atgcattatt taagcctgtc tctattgttg gaatttcagg 1380 tcattttcat aaatattgtt gcaataaata tccttgaaca ca 1422 <210> 274 <211> 3677 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(3677) <223> VEGFA mRNA <400> 274 tcgcggaggc ttggggcagc cgggtagctc ggaggtcgtg gcgctggggg ctagcaccag 60 cgctctgtcg ggaggcgcag cggttaggtg gaccggtcag cggactcacc ggccagggcg 120 ctcggtgctg gaatttgata ttcattgatc cgggttttat ccctcttctt ttttcttaaa 180 catttttttt taaaactgta ttgtttctcg ttttaattta tttttgcttg ccattcccca 240 cttgaatcgg gccgacggct tggggagatt gctctacttc cccaaatcac tgtggatttt 300 ggaaaccagc agaaagagga aagaggtagc aagagctcca gagagaagtc gaggaagaga 360 gagacggggt cagagagagc gcgcgggcgt gcgagcagcg aaagcgacag gggcaaagtg 420 agtgacctgc ttttgggggt gaccgccgga gcgcggcgtg agccctcccc cttgggatcc 480 cgcagctgac cagtcgcgct gacggacaga cagacagaca ccgcccccag ccccagctac 540 cacctcctcc ccggccggcg gcggacagtg gacgcggcgg cgagccgcgg gcaggggccg 600 gagcccgcgc ccggaggcgg ggtggagggg gtcggggctc gcggcgtcgc actgaaactt 660 ttcgtccaac ttctgggctg ttctcgcttc ggaggagccg tggtccgcgc gggggaagcc 720 gagccgagcg gagccgcgag aagtgctagc tcgggccggg aggagccgca gccggaggag 780 ggggaggagg aagaagagaa ggaagaggag agggggccgc agtggcgact cggcgctcgg 840 aagccgggct catggacggg tgaggcggcg gtgtgcgcag acagtgctcc agccgcgcgc 900 gctccccagg ccctggcccg ggcctcgggc cggggaggaa gagtagctcg ccgaggcgcc 960 gaggagagcg ggccgcccca cagcccgagc cggagaggga gcgcgagccg cgccggcccc 1020 ggtcgggcct ccgaaaccat gaactttctg ctgtcttggg tgcattggag ccttgccttg 1080 ctgctctacc tccaccatgc caagtggtcc caggctgcac ccatggcaga aggaggaggg 1140 cagaatcatc acgaagtggt gaagttcatg gatgtctatc agcgcagcta ctgccatcca 1200 atcgagaccc tggtggacat cttccaggag taccctgatg agatcgagta catcttcaag 1260 ccatcctgtg tgcccctgat gcgatgcggg ggctgctgca atgacgaggg cctggagtgt 1320 gtgcccactg aggagtccaa catcaccatg cagattatgc ggatcaaacc tcaccaaggc 1380 cagcacatag gagagatgag cttcctacag cacaacaaat gtgaatgcag accaaagaaa 1440 gatagagcaa gacaagaaaa aaaatcagtt cgaggaaagg gaaaggggca aaaacgaaag 1500 cgcaagaaat cccggtataa gtcctggagc gtgtacgttg gtgcccgctg ctgtctaatg 1560 ccctggagcc tccctggccc ccatccctgt gggccttgct cagagcggag aaagcatttg 1620 tttgtacaag atccgcagac gtgtaaatgt tcctgcaaaa acacagactc gcgttgcaag 1680 gcgaggcagc ttgagttaaa cgaacgtact tgcagatgtg acaagccgag gcggtgagcc 1740 gggcaggagg aaggagcctc cctcagggtt tcgggaacca gatctctcac caggaaagac 1800 tgatacagaa cgatcgatac agaaaccacg ctgccgccac cacaccatca ccatcgacag 1860 aacagtcctt aatccagaaa cctgaaatga aggaagagga gactctgcgc agagcacttt 1920 gggtccggag ggcgagactc cggcggaagc attcccgggc gggtgaccca gcacggtccc 1980 tcttggaatt ggattcgcca ttttattttt cttgctgcta aatcaccgag cccggaagat 2040 tagagagttt tatttctggg attcctgtag acacacccac ccacatacat acatttatat 2100 atatatatat tatatatata taaaaataaa tatctctatt ttatatatat aaaatatata 2160 tattcttttt ttaaattaac agtgctaatg ttattggtgt cttcactgga tgtatttgac 2220 tgctgtggac ttgagttggg aggggaatgt tcccactcag atcctgacag ggaagaggag 2280 gagatgagag actctggcat gatctttttt ttgtcccact tggtggggcc agggtcctct 2340 cccctgccca ggaatgtgca aggccagggc atgggggcaa atatgaccca gttttgggaa 2400 caccgacaaa cccagccctg gcgctgagcc tctctacccc aggtcagacg gacagaaaga 2460 cagatcacag gtacagggat gaggacaccg gctctgacca ggagtttggg gagcttcagg 2520 acattgctgt gctttgggga ttccctccac atgctgcacg cgcatctcgc ccccaggggc 2580 actgcctgga agattcagga gcctgggcgg ccttcgctta ctctcacctg cttctgagtt 2640 gcccaggaga ccactggcag atgtcccggc gaagagaaga gacacattgt tggaagaagc 2700 agcccatgac agctcccctt cctgggactc gccctcatcc tcttcctgct ccccttcctg 2760 gggtgcagcc taaaaggacc tatgtcctca caccattgaa accactagtt ctgtcccccc 2820 aggagacctg gttgtgtgtg tgtgagtggt tgaccttcct ccatcccctg gtccttccct 2880 tcccttcccg aggcacagag agacagggca ggatccacgt gcccattgtg gaggcagaga 2940 aaagagaaag tgttttatat acggtactta tttaatatcc ctttttaatt agaaattaaa 3000 acagttaatt taattaaaga gtagggtttt ttttcagtat tcttggttaa tatttaattt 3060 caactattta tgagatgtat cttttgctct ctcttgctct cttatttgta ccggtttttg 3120 tatataaaat tcatgtttcc aatctctctc tccctgatcg gtgacagtca ctagcttatc 3180 ttgaacagat atttaatttt gctaacactc agctctgccc tccccgatcc cctggctccc 3240 cagcacacat tcctttgaaa taaggtttca atatacatct acatactata tatatatttg 3300 gcaacttgta tttgtgtgta tatatatata tatatgttta tgtatatatg tgattctgat 3360 aaaatagaca ttgctattct gttttttata tgtaaaaaca aaacaagaaa aaatagagaa 3420 ttctacatac taaatctctc tcctttttta attttaatat ttgttatcat ttatttattg 3480 gtgctactgt ttatccgtaa taattgtggg gaaaagatat taacatcacg tctttgtctc 3540 tagtgcagtt tttcgagata ttccgtagta catatttatt tttaaacaac gacaaagaaa 3600 tacagatata tcttaaaaaa aaaaaagcat tttgtattaa agaatttaat tctgatctca 3660 aaaaaaaaaa aaaaaaa 3677 <210> 275 <211> 6194 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(6194) <223> WNT5A mRNA <400> 275 actaactcgc ggctgcagga tcagcgtctg gaagcagacg tttcggctac agacccagag 60 aggaggagct ggagatcagg aggcgtgagc cgccaagagt ttgcagaatc tgtggtgtga 120 atgaactggg ggcacctggg cgcacagatc gccccccttc ccccgccccg ggccacagtt 180 gagtagtggt acattttttt caccctcttg tgaagaattt ctttttatta ttatttgtcg 240 taaggtcttt tgcacaatca cgcccacatt tggggttgga aagccctaat taccgccgtc 300 gctgatggac gttggaaacg gagcgcctct ccgtggaaca gttgcctgcg cgccctcgcc 360 ggaccggcgg ctccctagtt gcgccccgac caggccctgc ccttgctgcc ggctcgcgcg 420 cgtccgcgcc ccctccattc ctgggcgcat cccagctctg ccccaactcg ggagtccagg 480 cccgggcgcc agtgcccgct tcagctccgg ttcactgcgc ccgccggacg cgcgccggag 540 gactccgcag ccctgctcct gaccgtcccc ccaggcttaa cccggtcgct ccgctcggat 600 tcctcggctg cgctcgctcg ggtggcgact tcctccccgc gccccctccc cctcgccatg 660 aagaagtcca ttggaatatt aagcccagga gttgctttgg ggatggctgg aagtgcaatg 720 tcttccaagt tcttcctagt ggctttggcc atatttttct ccttcgccca ggttgtaatt 780 gaagccaatt cttggtggtc gctaggtatg aataaccctg ttcagatgtc agaagtatat 840 attataggag cacagcctct ctgcagccaa ctggcaggac tttctcaagg acagaagaaa 900 ctgtgccact tgtatcagga ccacatgcag tacatcggag aaggcgcgaa gacaggcatc 960 aaagaatgcc agtatcaatt ccgacatcga aggtggaact gcagcactgt ggataacacc 1020 tctgtttttg gcagggtgat gcagataggc agccgcgaga cggccttcac atacgcggtg 1080 agcgcagcag gggtggtgaa cgccatgagc cgggcgtgcc gcgagggcga gctgtccacc 1140 tgcggctgca gccgcgccgc gcgccccaag gacctgccgc gggactggct ctggggcggc 1200 tgcggcgaca acatcgacta tggctaccgc tttgccaagg agttcgtgga cgcccgcgag 1260 cgggagcgca tccacgccaa gggctcctac gagagtgctc gcatcctcat gaacctgcac 1320 aacaacgagg ccggccgcag gacggtgtac aacctggctg atgtggcctg caagtgccat 1380 ggggtgtccg gctcatgtag cctgaagaca tgctggctgc agctggcaga cttccgcaag 1440 gtgggtgatg ccctgaagga gaagtacgac agcgcggcgg ccatgcggct caacagccgg 1500 ggcaagttgg tacaggtcaa cagccgcttc aactcgccca ccacacaaga cctggtctac 1560 atcgacccca gccctgacta ctgcgtgcgc aatgagagca ccggctcgct gggcacgcag 1620 ggccgcctgt gcaacaagac gtcggagggc atggatggct gcgagctcat gtgctgcggc 1680 cgtggctacg accagttcaa gaccgtgcag acggagcgct gccactgcaa gttccactgg 1740 tgctgctacg tcaagtgcaa gaagtgcacg gagatcgtgg accagtttgt gtgcaagtag 1800 tgggtgccac ccagcactca gccccgctcc caggacccgc ttatttatag aaagtacagt 1860 gattctggtt tttggttttt agaaatattt tttatttttc cccaagaatt gcaaccggaa 1920 ccattttttt tcctgttacc atctaagaac tctgtggttt attattaata ttataattat 1980 tatttggcaa taatgggggt gggaaccaag aaaaatattt attttgtgga tctttgaaaa 2040 ggtaatacaa gacttctttt gatagtatag aatgaagggg aaataacaca taccctaact 2100 tagctgtgtg gacatggtac acatccagaa ggtaaagaaa tacattttct ttttctcaaa 2160 tatgccatca tatgggatgg gtaggttcca gttgaaagag ggtggtagaa atctattcac 2220 aattcagctt ctatgaccaa aatgagttgt aaattctctg gtgcaagata aaaggtcttg 2280 ggaaaacaaa acaaaacaaa acaaacctcc cttccccagc agggctgcta gcttgctttc 2340 tgcattttca aaatgataat ttacaatgga aggacaagaa tgtcatattc tcaaggaaaa 2400 aaggtatatc acatgtctca ttctcctcaa atattccatt tgcagacaga ccgtcatatt 2460 ctaatagctc atgaaatttg ggcagcaggg aggaaagtcc ccagaaatta aaaaatttaa 2520 aactcttatg tcaagatgtt gatttgaagc tgttataaga attaggattc cagattgtaa 2580 aaagatcccc aaatgattct ggacactaga tttttttgtt tggggaggtt ggcttgaaca 2640 taaatgaaaa tatcctgtta ttttcttagg gatacttggt tagtaaatta taatagtaaa 2700 aataatacat gaatcccatt cacaggttct cagcccaagc aacaaggtaa ttgcgtgcca 2760 ttcagcactg caccagagca gacaacctat ttgaggaaaa acagtgaaat ccaccttcct 2820 cttcacactg agccctctct gattcctccg tgttgtgatg tgatgctggc cacgtttcca 2880 aacggcagct ccactgggtc ccctttggtt gtaggacagg aaatgaaaca ttaggagctc 2940 tgcttggaaa acagttcact acttagggat ttttgtttcc taaaactttt attttgagga 3000 gcagtagttt tctatgtttt aatgacagaa cttggctaat ggaattcaca gaggtgttgc 3060 agcgtatcac tgttatgatc ctgtgtttag attatccact catgcttctc ctattgtact 3120 gcaggtgtac cttaaaactg ttcccagtgt acttgaacag ttgcatttat aaggggggaa 3180 atgtggttta atggtgcctg atatctcaaa gtcttttgta cataacatat atatatatat 3240 acatatatat aaatataaat ataaatatat ctcattgcag ccagtgattt agatttacag 3300 tttactctgg ggttatttct ctgtctagag cattgttgtc cttcactgca gtccagttgg 3360 gattattcca aaagtttttt gagtcttgag cttgggctgt ggccctgctg tgatcatacc 3420 ttgagcacga cgaagcaacc ttgtttctga ggaagcttga gttctgactc actgaaatgc 3480 gtgttgggtt gaagatatct tttttctttt ctgcctcacc cctttgtctc caacctccat 3540 ttctgttcac tttgtggaga gggcattact tgttcgttat agacatggac gttaagagat 3600 attcaaaact cagaagcatc agcaatgttt ctcttttctt agttcattct gcagaatgga 3660 aacccatgcc tattagaaat gacagtactt attaattgag tccctaagga atattcagcc 3720 cactacatag atagcttttt tttttttttt tttaataagg acacctcttt ccaaacagtg 3780 ccatcaaata tgttcttatc tcagacttac gttgttttaa aagtttggaa agatacacat 3840 ctttcatacc ccccttaggc aggttggctt tcatatcacc tcagccaact gtggctctta 3900 atttattgca taatgatatt cacatcccct cagttgcagt gaattgtgag caaaagatct 3960 tgaaagcaaa aagcactaat tagtttaaaa tgtcactttt ttggttttta ttatacaaaa 4020 accatgaagt acttttttta tttgctaaat cagattgttc ctttttagtg actcatgttt 4080 atgaagagag ttgagtttaa caatcctagc ttttaaaaga aactatttaa tgtaaaatat 4140 tctacatgtc attcagatat tatgtatatc ttctagcctt tattctgtac ttttaatgta 4200 catatttctg tcttgcgtga tttgtatatt tcactggttt aaaaaacaaa catcgaaagg 4260 cttatgccaa atggaagata gaatataaaa taaaacgtta cttgtatatt ggtaagtggt 4320 ttcaattgtc cttcagataa ttcatgtgga gatttttgga gaaaccatga cggatagttt 4380 aggatgacta catgtcaaag taataaaaga gtggtgaatt ttaccaaaac caagctattt 4440 ggaagcttca aaaggtttct atatgtaatg gaacaaaagg ggaattctct tttcctatat 4500 atgttcctta caaaaaaaaa aaaaaaagaa atcaagcaga tggcttaaag ctggttatag 4560 gattgctcac attcttttag cattatgcat gtaacttaat tgttttagag cgtgttgctg 4620 ttgtaacatc ccagagaaga atgaaaaggc acatgctttt atccgtgacc agatttttag 4680 tccaaaaaaa tgtatttttt tgtgtgttta ccactgcaac tattgcacct ctctatttga 4740 atttactgtg gaccatgtgt ggtgtctcta tgccctttga aagcagtttt tataaaaaga 4800 aagcccgggt ctgcagagaa tgaaaactgg ttggaaacta aaggttcatt gtgttaagtg 4860 caattaatac aagttattgt gcttttcaaa aatgtacacg gaaatctgga cagtgctcca 4920 cagattgata cattagcctt tgctttttct ctttccggat aaccttgtaa catattgaaa 4980 ccttttaagg atgccaagaa tgcattattc cacaaaaaaa cagcagacca acatatagag 5040 tgtttaaaat agcatttctg ggcaaattca aactcttgtg gttctaggac tcacatctgt 5100 ttcagttttt cctcagttgt atattgacca gtgttcttta ttgcaaaaac atatacccga 5160 tttagcagtg tcagcgtatt ttttcttctc atcctggagc gtattcaaga tcttcccaat 5220 acaagaaaat taataaaaaa tttatatata ggcagcagca aaagagccat gttcaaaata 5280 gtcattatgg gctcaaatag aaagaagact tttaagtttt aatccagttt atctgttgag 5340 ttctgtgagc tactgacctc ctgagactgg cactgtgtaa gttttagttg cctaccctag 5400 ctcttttctc gtacaatttt gccaatacca agtttcaatt tgtttttaca aaacattatt 5460 caagccacta gaattatcaa atatgacgct atagcagagt aaatactctg aataagagac 5520 cggtactagc taactccaag agatcgttag cagcatcagt ccacaaacac ttagtggccc 5580 acaatatata gagagataga aaaggtagtt ataacttgaa gcatgtattt aatgcaaata 5640 ggcacgaagg cacaggtcta aaatactaca ttgtcactgt aagctatact tttaaaatat 5700 ttattttttt taaagtattt tctagtcttt tctctctctg tggaatggtg aaagagagat 5760 gccgtgtttt gaaagtaaga tgatgaaatg aatttttaat tcaagaaaca ttcagaaaca 5820 taggaattaa aacttagaga aatgatctaa tttccctgtt cacacaaact ttacacttta 5880 atctgatgat tggatatttt attttagtga aacatcatct tgttagctaa ctttaaaaaa 5940 tggatgtaga atgattaaag gttggtatga ttttttttta atgtatcagt ttgaacctag 6000 aatattgaat taaaatgctg tctcagtatt ttaaaagcaa aaaaggaatg gaggaaaatt 6060 gcatcttaga ccatttttat atgcagtgta caatttgctg ggctagaaat gagataaaga 6120 ttatttattt ttgttcatat cttgtacttt tctattaaaa tcattttatg aaatccaaaa 6180 aaaaaaaaaa aaaa 6194 <210> 276 <211> 1309 <212> RNA <213> Homo sapiens <220> <221> mRNA <222> (1)..(1309) <223> GAPDH mRNA <400> 276 gctctctgct cctcctgttc gacagtcagc cgcatcttct tttgcgtcgc cagccgagcc 60 acatcgctca gacaccatgg ggaaggtgaa ggtcggagtc aacggatttg gtcgtattgg 120 gcgcctggtc accagggctg cttttaactc tggtaaagtg gatattgttg ccatcaatga 180 ccccttcatt gacctcaact acatggttta catgttccaa tatgattcca cccatggcaa 240 attccatggc accgtcaagg ctgagaacgg gaagcttgtc atcaatggaa atcccatcac 300 catcttccag gagcgagatc cctccaaaat caagtggggc gatgctggcg ctgagtacgt 360 cgtggagtcc actggcgtct tcaccaccat ggagaaggct ggggctcatt tgcagggggg 420 agccaaaagg gtcatcatct ctgccccctc tgctgatgcc cccatgttcg tcatgggtgt 480 gaaccatgag aagtatgaca acagcctcaa gatcatcagc aatgcctcct gcaccaccaa 540 ctgcttagca cccctggcca aggtcatcca tgacaacttt ggtatcgtgg aaggactcat 600 gaccacagtc catgccatca ctgccaccca gaagactgtg gatggcccct ccgggaaact 660 gtggcgtgat ggccgcgggg ctctccagaa catcatccct gcctctactg gcgctgccaa 720 ggctgtgggc aaggtcatcc ctgagctgaa cgggaagctc actggcatgg ccttccgtgt 780 ccccactgcc aacgtgtcag tggtggacct gacctgccgt ctagaaaaac ctgccaaata 840 tgatgacatc aagaaggtgg tgaagcaggc gtcggagggc cccctcaagg gcatcctggg 900 ctacactgag caccaggtgg tctcctctga cttcaacagc gacacccact cctccacctt 960 tgacgctggg gctggcattg ccctcaacga ccactttgtc aagctcattt cctggtatga 1020 caacgaattt ggctacagca acagggtggt ggacctcatg gcccacatgg cctccaagga 1080 gtaagacccc tggaccacca gccccagcaa gagcacaaga ggaagagaga gaccctcact 1140 gctggggagt ccctgccaca ctcagtcccc caccacactg aatctcccct cctcacagtt 1200 gccatgtaga ccccttgaag aggggagggg cctagggagc cgcaccttgt catgtaccat 1260 caataaagta ccctgtgctc aaccagttaa aaaaaaaaaa aaaaaaaaa 1309

Claims (8)

ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, ENO1, ERRFI1, ESM1,FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3,IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5,ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, VISFATIN, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2,TGFB1, TGFBR3, TIMP1, TMEM158, TNFAIP6, VEGFA, WNT5A, 및 GAPDH로 이루어진 군으로부터 선택되는 하나 이상의 유전자에 상보적인 프라이머(primer) 세트 또는 프로브 세트를 포함하는, 상처 치료제 스크리닝용 조성물.
ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, EMP1 FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3,IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5,ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, VISFATIN, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2, TGFB1, TGFBR3, TIMP1, TMEM158, TNFA, GA A composition for screening a wound treatment comprising a primer set or a probe set complementary to one or more genes selected from the group consisting of.
제1항에 있어서,
상기 프로브 세트는 형광 표지 물질을 갖는 표지 프로브 세트인 것을 특징으로 하는, 상처 치료제 스크리닝용 조성물.
According to claim 1,
The probe set is characterized in that a set of probes labeled with a fluorescent label material, the composition for screening wound treatment.
ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, ENO1, ERRFI1, ESM1,FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3,IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5,ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, VISFATIN, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2,TGFB1, TGFBR3, TIMP1, TMEM158, TNFAIP6, VEGFA, WNT5A, 및 GAPDH 의 유전자로부터 코딩되는 단백질로 이루어진 군으로부터 선택되는 하나 이상의 단백질에 특이적으로 결합하는 항체, 압타머, 또는 리간드를 포함하는, 상처 치료제 스크리닝용 조성물.
ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, EMP1 FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3,IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5,ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, VISFATIN, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2, TGFB1, TGFBR3, TIMP1, TMEM158, TNFA, GA A composition for screening a wound treatment comprising an antibody, an aptamer, or a ligand that specifically binds to one or more proteins selected from the group consisting of proteins encoded from the genes of.
제1항 또는 제3항의 조성물을 포함하는 상처 치료제 스크리닝용 키트.
A kit for screening a wound treatment comprising the composition of claim 1 or 3.
(a) 섬유아세포에 분석하고자 하는 시료를 처리하는 단계;
(b) 상기 섬유아세포에서 ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, ENO1, ERRFI1, ESM1,FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3,IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5,ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, VISFATIN, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2,TGFB1, TGFBR3, TIMP1, TMEM158, TNFAIP6, VEGFA, WNT5A, 및 GAPDH로 이루어진 군으로부터 선택되는 하나 이상의 유전자 발현량을 측정하는 단계; 및
(c)상기 시료의 처리로 (b)단계에서 유전자 발현량이 증가하는 경우 상처치료제로 선별하는 단계;
를 포함하는, 상처 치료제를 스크리닝하는 방법.
(A) processing the sample to be analyzed in the fibroblasts;
(b) ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EEG, EFR in the fibroblasts. , ERRFI1, ESM1,FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3,IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL -7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5,ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, VISFATIN, NPAS2, PDGFA , PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2,TGFB1, TGFBR3, TIMP1158 , Measuring one or more gene expression levels selected from the group consisting of VEGFA, WNT5A, and GAPDH; And
(c) when the gene expression in step (b) increases due to the treatment of the sample, screening with a wound treatment agent;
A method of screening a wound treatment comprising a.
ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, ENO1, ERRFI1, ESM1,FGA, FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3,IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5,ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, VISFATIN, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2,TGFB1, TGFBR3, TIMP1, TMEM158, TNFAIP6, VEGFA, WNT5A, 및 GAPDH의 유전자로부터 코딩되는 단백질로 이루어진 군으로부터 선택되는 하나 이상의 단백질을 유효성분으로 포함하는 상처 치료용 약학적 조성물.
ACTA2, BMPER, CCL2, CH25H, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, CSF3, CTGF, CTNNB1, CTSK, CXCL1, CXCL5, CXCL6, DUSP6, EGFR, EGR1, EMP1, EMP1 FGF2, FGF7, FGF10, FOSL1, FST, HAS2, HBEGF, HGF, HMGA2, ICAM1, IER3,IL-13RA2, IL-33, IL-1B, IL-6, IL-6ST, IL-7R, IL-8, ITGA1, ITGA2, ITGA3, ITGA4, ITGA5,ITGAV, ITGB1, ITGB3, ITGB5, KRTAP1-5, LPXN, MAPK1, MAPK3, MCL1, MIF, MMP1, MMP2, MMP3, VISFATIN, NPAS2, PDGFA, PLAT, PLAU, PLAUR, PLG, PTEN, PTGS2, PTX3, RAC1, RHOA, SERPINB2, SERPINE1, SERPINE2, SLC20A1, SLIT2, SMURF2, STAT3, STC1, SDC4, TAGLN, TFPI2, TGFB1, TGFBR3, TIMP1, TMEM158, TNFA, GA A pharmaceutical composition for treating wounds comprising at least one protein selected from the group consisting of proteins encoded from the gene of the active ingredient.
제6항에 있어서,
상기 단백질은 VISFATIN또는 STC1 단백질인 것을 특징으로 하는, 상처 치료용 약학적 조성물.
The method of claim 6,
The protein is characterized in that the VISFATIN or STC1 protein, pharmaceutical composition for wound healing.
제6항에 있어서,
상기 상처 치료용 약학적 조성물은,
ERK(extracelluar signal-regulated kinases) 및 JNK(c-jun N-termial kinases)의 활성화를 유도해서 혈관내피성장인자(Vascular endothelial growth factor; VEGF)의 발현을 증가시키는 것을 특징으로 하는, 상처 치료용 약학적 조성물.

The method of claim 6,
The pharmaceutical composition for treating wounds,
Induced by activation of extracelluar signal-regulated kinases (ERK) and c-jun N-termial kinases (JNK), thereby increasing the expression of Vascular endothelial growth factor (VEGF). Ever composition.

KR1020180158538A 2018-12-10 2018-12-10 Composition for the screening of wound healing agent and screening method for the same KR102195319B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020180158538A KR102195319B1 (en) 2018-12-10 2018-12-10 Composition for the screening of wound healing agent and screening method for the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020180158538A KR102195319B1 (en) 2018-12-10 2018-12-10 Composition for the screening of wound healing agent and screening method for the same

Publications (2)

Publication Number Publication Date
KR20200070890A true KR20200070890A (en) 2020-06-18
KR102195319B1 KR102195319B1 (en) 2020-12-24

Family

ID=71142963

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020180158538A KR102195319B1 (en) 2018-12-10 2018-12-10 Composition for the screening of wound healing agent and screening method for the same

Country Status (1)

Country Link
KR (1) KR102195319B1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022196668A1 (en) * 2021-03-16 2022-09-22 塩野義製薬株式会社 Nucleic acid drug targeting itgav
CN116718784A (en) * 2023-06-19 2023-09-08 十堰市太和医院（湖北医药学院附属医院） Application of STC1 as glioma marker
CN117051111A (en) * 2023-10-12 2023-11-14 上海爱谱蒂康生物科技有限公司 Application of biomarker combination in preparation of kit for predicting lung cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090010662A (en) * 2007-07-24 2009-01-30 부산대학교 산학협력단 Pharmaceutical composition for angiogenesis stimulation comprising visfatin as an active ingredient
KR101796141B1 (en) 2015-12-07 2017-11-13 서울대학교산학협력단 Multifunctional therapeutic silver and vitamin B6 complex, preparation method thereof, and wound healing pharmaceutical composition containing the same as active ingredient

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090010662A (en) * 2007-07-24 2009-01-30 부산대학교 산학협력단 Pharmaceutical composition for angiogenesis stimulation comprising visfatin as an active ingredient
KR101796141B1 (en) 2015-12-07 2017-11-13 서울대학교산학협력단 Multifunctional therapeutic silver and vitamin B6 complex, preparation method thereof, and wound healing pharmaceutical composition containing the same as active ingredient

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Int. J. Mol. Sci. 2018, 19, 3642* *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022196668A1 (en) * 2021-03-16 2022-09-22 塩野義製薬株式会社 Nucleic acid drug targeting itgav
CN116718784A (en) * 2023-06-19 2023-09-08 十堰市太和医院（湖北医药学院附属医院） Application of STC1 as glioma marker
CN117051111A (en) * 2023-10-12 2023-11-14 上海爱谱蒂康生物科技有限公司 Application of biomarker combination in preparation of kit for predicting lung cancer
CN117051111B (en) * 2023-10-12 2024-01-26 上海爱谱蒂康生物科技有限公司 Application of biomarker combination in preparation of kit for predicting lung cancer

Also Published As

Publication number Publication date
KR102195319B1 (en) 2020-12-24

Similar Documents

Publication Publication Date Title
AU2020270508B2 (en) C/EBP alpha short activating RNA compositions and methods of use
KR101234281B1 (en) Cancer cell-specific apoptosis-inducing agents that target chromosome stabilization-associated genes
US6262333B1 (en) Human genes and gene expression products
KR20210049859A (en) Methods and compositions for regulating the genome
KR101778036B1 (en) Phosphodiesterase 4D7 as prostate cancer marker
AU2016376191A1 (en) Materials and methods for treatment of amyotrophic lateral sclerosis and/or frontal temporal lobular degeneration
AU2016364667A1 (en) Materials and methods for treatment of Alpha-1 antitrypsin deficiency
KR102149483B1 (en) Use of masitinib for treatment of cancer in patient subpopulations identified using predictor factors
KR20120082906A (en) Methods for modulation of autophagy through the modulation of autophagy-enhancing gene products
WO1995014772A1 (en) Gene signature
KR20210138587A (en) Combination Gene Targets for Improved Immunotherapy
KR20150013507A (en) Methods and compositions for modulating apolipoprotein (a) expression
KR20190120204A (en) Inhibitors of ATR Kinase for Use in Methods of Treating Hyperproliferative Diseases
CN101258250A (en) Method for breast cancer diagnosis
KR20040065524A (en) Method for assessing and treating leukemia
KR20220054401A (en) Systems, methods and compositions for rapid early-detection of host RNA biomarkers of infection and early identification of COVID-19 coronavirus infection in humans
KR102195319B1 (en) Composition for the screening of wound healing agent and screening method for the same
KR20220024184A (en) detection of colorectal cancer
KR20140113021A (en) Biomarkers for confirmation of drug addiction and dependence
KR20210144822A (en) Compounds and methods for modulating UBE3A-ATS
JP2003259877A (en) Marker for hepatic fibrosis disease and application of the same
KR20190126812A (en) Biomarkers for Disease Diagnosis
WO2018209358A2 (en) Systemic delivery of polypeptides
US20220265798A1 (en) Cancer vaccine compositions and methods for using same to prevent and/or treat cancer
TW202227102A (en) Method of treating fatty liver disease

Legal Events

Date Code Title Description
E701 Decision to grant or registration of patent right
GRNT Written decision to grant