KR20200068813A - Cranial window cartridge for prevention, diagnosis and treatment of brain diseases - Google Patents

Abstract

The present invention relates to a cranial window cartridge for diagnosis, prevention or treatment of brain diseases. The cranial window cartridge according to an embodiment of the present invention can be detached from a cranial removing portion, and enables direct treatment of brain diseases while visualizing exposed brain tissue by using biocompatible ingredients such as hydrogels.

Description

Cranial window cartridge for prevention, diagnosis and treatment of brain diseases {CRANIAL WINDOW CARTRIDGE FOR PREVENTION, DIAGNOSIS AND TREATMENT OF BRAIN DISEASES}

The present invention relates to a skull window cartridge for the prevention, diagnosis, and treatment of brain diseases, and more particularly, includes a biocompatible component such as hydrogel, and is applied through a region of the brain where the skull is removed and exposed to the outside. The present invention relates to a device capable of protecting and visualizing the cerebral neurovascular system and enabling direct treatment of the cerebral nervous system through a region of the exposed brain.

Cerebrovascular disease is so common that it occurs in 1 in 3 people, and the mortality rate and the incidence of permanent disability are very high, which is a disease that suffers greatly from individual suffering and national economic burden. Prophylactic or therapeutic methods of cerebrovascular diseases of oral or intravenous drugs systemically developed so far have limited effectiveness and few side effects.

In order to overcome these limited effects and side effects, research into performing a direct treatment for an acute or chronic brain disease by removing a skull that serves as a buffer that safely protects the brain from external shock has been actively conducted.

The area where the skull is removed for direct treatment as described above is generally referred to as a cranial window, and a skull substitute used to protect the brain area exposed by the skull window is a cranial window cartridge. ). Currently, a cover glass material is mainly used as a material for the skull window cartridge. However, due to the hard material of the skull window cartridge of the cover glass material, direct observation of the brain is possible, but there is a problem that direct stimulation or treatment of the brain is impossible.

Accordingly, there is a need for a new level of skull window cartridge that allows the brain to be monitored for the diagnosis, prevention, or treatment of cerebrovascular disease while monitoring the condition of the brain and enabling direct treatment for the brain.

Japanese Patent Application Publication No. 2013-520216 (2013.06.06)

The present invention is to solve the problems as described above, by using a biocompatible component such as hydrogel, so as to visualize a region of the brain exposed by the skull window, and at the same time direct stimulation and treatment for the brain is possible It is an object to provide a device to do.

In addition, by measuring and using biological signals related to brain disease, a device capable of monitoring the state of the brain in real time and serving as a target therapeutic platform that manages the entire process of prevention, diagnosis, and treatment of brain disease The purpose is to provide.

A cranial window cartridge for diagnosis, prevention or treatment of brain disease according to an embodiment of the present invention includes a hydrogel, and may be detachable from and removed from the skull.

Hydrogel contained in the skull window cartridge according to an embodiment of the present invention is formed by mixing with a drug for the treatment of brain disease, the drug mixed with the hydrogel can be released to the area of the exposed brain by removing the skull .

The hydrogel included in the skull window cartridge according to an embodiment of the present invention may have a kernel-type structure corresponding to a channel in the skull.

The skull window cartridge according to an embodiment of the present invention may include a sensing module for measuring a biosignal.

According to the skull window cartridge provided as an embodiment of the present invention, the state of internal tissues, including blood vessels of the brain, can be directly observed and monitored by a clinician through the cartridge itself, an emergency occurs or direct treatment If necessary, it can be used as a route to directly access the brain and cerebral blood vessels so that local or systemic treatment can be performed quickly.

In addition, according to the skull window cartridge provided as an embodiment of the present invention, by using biocompatible components such as hydrogel, it is possible to secure contact stability of the cerebral blood vessels and minimize the risk of infection or inflammation.

In addition, according to the skull window cartridge provided as an embodiment of the present invention, since bio-signal measurement and drug secretion can be performed in real time, clinicians, etc. of brain disease management leading to prevention-diagnosis-treatment of brain diseases You can effectively perform and manage the entire process.

1 is a first cross-sectional view showing a state in which a skull window cartridge according to an embodiment of the present invention is mounted on a removal portion of the skull.
Figure 2a shows the results of checking the channel (channel) in the skull.
FIG. 2B shows the result of 3D (3-dimention) imaging of a channel in the skull.
Figure 3 is a second cross-sectional view showing a state in which the skull window cartridge according to an embodiment of the present invention is mounted on the removal portion of the skull.

Terms used in the specification will be briefly described, and the present invention will be described in detail.

The terminology used in the present invention has been selected, while considering the functions in the present invention, general terms that are currently widely used are selected, but this may vary according to the intention or precedent of a person skilled in the art or the appearance of a new technology. In addition, in certain cases, some terms are arbitrarily selected by the applicant, and in this case, their meanings will be described in detail in the description of the applicable invention. Therefore, the terms used in the present invention should be defined based on the meanings of the terms and the contents of the present invention, not simply the names of the terms.

When a part of the specification "includes" a certain component, this means that other components may be further included instead of excluding other components, unless specifically stated to the contrary. In addition, terms such as “module” described in the specification mean a unit that processes at least one function or operation, which may be implemented in hardware or a combination of hardware and software.

In addition, when a part is "connected" with another part in the specification, this includes not only "directly connected" but also "connected with other components in between".

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art to which the present invention pertains can easily practice. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. In addition, in order to clearly describe the present invention in the drawings, parts irrelevant to the description are omitted, and like reference numerals are assigned to similar parts throughout the specification.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

1 is a first cross-sectional view showing a state in which the skull window cartridge 100 according to an embodiment of the present invention is mounted on the removal part 10 of the skull.

Referring to FIG. 1, a cranial window cartridge 100 for diagnosis, prevention or treatment of brain disease according to an embodiment of the present invention may be detachable from the removal site 10 of the skull. At this time, the skull window cartridge 100 may be manufactured in various ways according to the size of the removal portion 10 of the skull so that it can be worn to fit the size of the removal portion 10 of the skull.

The skull window cartridge of the conventional cover glass material is difficult to remove once it is fixed to the removal portion of the skull. Due to these difficulties, when treatment for the entire exposed area needs to be performed depending on the progression of brain disease, a problem may not occur due to the inability to remove the skull window cartridge and prevent proper treatment.

Skull window cartridge 100 according to an embodiment of the present invention by including a biocompatible component such as hydrogel (hydrogel), smoothly to the removal portion 10 of the skull without a separate configuration or adhesive member for fixing Can be removed. For example, the skull window cartridge 100 including a hydrogel may have a fixing force by directly contacting a brain surface duramater or a subarachnoid membrane exposed by the removal of the skull, and the fixed skull window cartridge 100 may be easily removed through a removal device having a suction force.

On the other hand, the hydrogel which is a biocompatible component constituting the skull window cartridge 100 according to an embodiment of the present invention is a water-soluble polymer physical (ex. hydrogen bond, van der Waals force, hydrogen-water interaction, etc.) or chemical (ex. Covalent bond) It is a network structure that is formed in a three-dimensional form by bonding, and refers to a substance that does not dissolve in an aqueous environment and can contain a considerable amount of water.

Hydrogels have high biocompatibility due to their high water content and physicochemical similarity to the extracellular matrix. Due to such high biocompatibility, the skull window cartridge 100 including a hydrogel has stability even if it directly contacts the meninges or cerebral blood vessels, and can minimize the occurrence of infection or inflammation due to contact or invasion of bacteria.

In addition, the hydrogel may be formed by mixing with a drug, and linear polymers, nanoparticles, etc. may be used as a drug delivery agent in the mixing process. The drug delivery system may cause the drug mixed with the hydrogel to be released into the body according to a change in pH or elapse of time in vivo.

Using these characteristics, the hydrogel included in the skull window cartridge 100 according to an embodiment of the present invention may be formed by mixing with a drug for the treatment of brain diseases. For example, an agent for treating brain diseases such as an antiplatelet, an anticoagulant, or a hyperlipidemic agent may be mixed with a hydrogel through a drug delivery system composed of linear polymers or nanoparticles. As such, the drug mixed with the hydrogel can be directly released to the exposed area 20 of the brain by removing the skull, such as a change in pH or in time. At this time, the time or cycle of drug release (or secretion) into the body may vary depending on the type of drug delivery system and the mixing method with the hydrogel.

The skull window cartridge 100 including the hydrogel having such characteristics can stably protect the exposed area 20 of the brain from which the skull has been removed, and a clinician or the like directly protects biological tissues such as brain blood vessels of the brain. It can be visualized for observation.

FIG. 2A shows a result of checking a channel in the skull, and FIG. 2B shows a result of 3D (3-dimention) imaging of a channel in the skull.

The channel in the skull here refers to a pathway through which inflammatory cells move from the skull to the brain. A plurality of such channels are formed in the skull. For example, referring to Figure A of FIG. 2A, which is a cross-sectional image of a skull based on 1 micrometer (mm), it can be seen that a channel is formed in the skull that is connected to a marrow cavity. Referring to FIG. B of FIG. 2A, which is an image taken on the outer surface of the skull based on 1 micrometer (mm), it can be confirmed that a plurality of channels are irregularly formed on the outer surface of the skull.

In addition, referring to Figures B and C of Figure 2b, it can be seen that a plurality of channels formed in the skull is formed in the form of a passage through each layer constituting the skull.

The hydrogel included in the skull window cartridge 100 according to an embodiment of the present invention may have a kernel-type structure corresponding to a channel in the skull. That is, the hydrogel may be formed in a structure in which a passage through which a drug or the like can move is provided by reflecting the size and shape of a channel in the skull.

As described above, when the hydrogel is formed into a kernel-like structure reflecting the size, shape, etc. of channels in the skull, the skull window cartridge 100 as a substitute for the skull can provide an environment similar to the skull to the exposed area, and minimize heterogeneity. have.

In addition, in the state where the skull window cartridge 100 is mounted, according to the state of the brain disease, topical treatment of a method of directly accessing the brain and cerebral blood vessels via the cartridge from outside the body (ex. arterial catheterization, etc.), Drug injection treatment for cerebral blood vessels and the like can be effectively performed.

That is, even though the skull window cartridge 100 according to an embodiment of the present invention is not removed through a hydrogel having a kernel-type structure corresponding to a channel in the skull, drug injection treatment, etc., which directly accesses the brain and cerebral blood vessels from outside the body It can be performed quickly by a clinician or the like.

3 is a second cross-sectional view showing a state in which the skull window cartridge 100 according to an embodiment of the present invention is mounted on the removal part 10 of the skull.

Referring to FIG. 3, the skull window cartridge 100 according to an embodiment of the present invention may include a sensing module 110 for measuring a biosignal. At this time, the measured bio-signals may include signals for brain cortical brain blood flow, brain waves, oxygen saturation, brain bleeding, and brain pressure as signals for monitoring brain diseases.

The sensing module 110 according to an embodiment of the present invention may be a MEMS (microelectromechanical systemsm, MEMS) sensor capable of effective signal measurement even in a narrow area. The MEMS sensor has a size of several micrometers to several nanometers, and can transmit a biosignal measured in another external terminal using a wireless communication method.

The sensing module 110 according to an embodiment of the present invention may be provided in an area of the skull window cartridge 100 so as to directly contact the exposed area 20 of the brain. For example, as shown in Figure 3, the sensing module 110 may be provided in a form that is inserted into the center of the skull window cartridge 100, and the skull window cartridge 100 is mounted on the removal part 10 of the skull, thereby allowing the brain It may be in direct contact with the exposed area 20 of. However, the provided form of the sensing module 110 is not limited to the above-described examples, and the provided form may be changed according to purposes such as prevention, diagnosis, or treatment of brain diseases.

Referring to FIG. 3, the sensing module 110 according to an embodiment of the present invention may be linked to the monitoring terminal 120 provided outside the body using wireless communication. At this time, the monitoring terminal 120 refers to a computing terminal or a server capable of wireless communication, a smart phone, a portable multimedia player (PMP), a personal digital assistants (PDA), a desktop PC, a laptop PC, It may be a tablet PC, a database server, or the like.

That is, the biological signal related to the brain disease measured through the sensing module 110 may be transmitted to the monitoring terminal 120 through wireless communication. The bio-signal transmitted to the monitoring terminal 120 may be converted or estimated as information for checking the state of the brain and blood vessels, and output. At this time, when it is determined that the state of the patient's brain disease is an emergency situation (eg, occurrence of brain hemorrhage, etc.) according to a biosignal in the process of information conversion or estimation in the monitoring terminal 120, registered as the primary care physician of the patient An alarm signal for rapid treatment may be transmitted to a terminal, an emergency center terminal, or the like, or an alarm signal for rapid treatment may be output from the monitoring terminal 120 itself.

Based on the signal or information output through the sensing module 110 and the monitoring terminal 120, the clinician, etc. can monitor the patient's condition in real time, and whether the onset of brain disease, progress, treatment direction, etc. By determining, it is possible to efficiently manage the entire process of prevention, diagnosis and treatment of brain diseases.

The above description of the present invention is for illustration only, and those skilled in the art to which the present invention pertains can understand that the present invention can be easily modified into other specific forms without changing the technical spirit or essential features of the present invention. will be. Therefore, it should be understood that the embodiments described above are illustrative in all respects and not restrictive. For example, each component described as a single type may be implemented in a distributed manner, and similarly, components described as distributed may be implemented in a combined form.

The scope of the present invention is indicated by the following claims rather than the detailed description, and all changes or modifications derived from the meaning and scope of the claims and their equivalent concepts should be interpreted to be included in the scope of the present invention. .

10: skull removal area 20: brain exposed area
100: skull window cartridge
110: sensing module
200: monitoring terminal

Claims (4)

A cranial window cartridge for diagnosis, prevention or treatment of brain diseases. A cranial window cartridge comprising a hydrogel and detachable from and removed from the skull.
According to claim 1,
The hydrogel is formed by mixing with a drug for the treatment of brain diseases,
The skull window cartridge, characterized in that the drug mixed with the hydrogel is released to the area of the exposed brain by removing the skull.
According to claim 1,
The hydrogel is a skull window cartridge, characterized in that it has a kernel (canal) structure corresponding to the channel (channel) in the skull.
According to claim 1,
Skull window cartridge, characterized in that a sensing module for measuring a biosignal is included.

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