KR20200057249A - Pulse sensing module, blood pressure calculation module, blood pressure measuring device and method for manufacturing pulse sensing module - Google Patents

Abstract

According to an embodiment of the present invention, provided is a pulse sensing module which is attached on a skin to be used as a blood pressure measurement device so that at least one of systolic pressure, diastolic pressure, blood pressure variance is measured. The pulse sensing module comprises: a piezoelectric layer including a piezoelectric material for generating a piezoelectric effect by a pulse; and a protection layer protecting the piezoelectric layer by being applied on the piezoelectric layer and having an aperture to expose a part of regions of a first electrode line and a part of regions of a second electrode line so that a polling process applying high voltage to the first electrode line and the second electrode line formed on the piezoelectric layer is possible to improve polarity of the piezoelectric material.

Description

Pulse sensing module, blood pressure calculation module, blood pressure measuring device and method for manufacturing pulse sensing module}

The present invention relates to a pulse sensing module, a blood pressure calculating module, a blood pressure measuring device, and a manufacturing method of a pulse sensing module, and more specifically, a pulse sensing module, a blood pressure calculating module, and a blood pressure to measure blood pressure with a piezoelectric effect through a piezoelectric substance It relates to a measuring device and a manufacturing method of the pulse sensing module.

Recently, living standards and health consciousness are increasing, and interest and demand for health examinations are increasing.

In general, basic medical examinations are used to measure blood pressure, pulse wave, electrocardiogram, and body fat as basic data.

To this end, each clinic is equipped with a blood pressure monitor for measuring blood pressure, an electrocardiogram measuring device for measuring ECG, a body fat measuring device for measuring body fat, a pressure pulse wave meter for measuring pulse waves, a volume pulse wave meter for measuring blood flow, and the like. .

Of these, the blood pressure monitor for blood pressure measurement was a method of tightening and measuring to fit the circumference of the upper arm after putting the arm-shaped compression part on the upper arm of the subject as disclosed in Korean Patent Registration No. 10-1059528.

However, this type of blood pressure measurement caused discomfort in that the subject had to tighten the arm-shaped compression part with one hand when measuring the blood pressure by himself.

In addition, in recent years, a space in which the upper arm is inserted is fixedly formed in a circular shape, and when the examinee presses a button after inserting the upper arm into the circular space, the pressure bar automatically inflates and tightens the upper arm. have.

However, since the blood pressure measuring device needs to insert the upper arm into the circular space, the distance to which the subject's arm has to be moved becomes longer, which causes discomfort, and in the case of the test subject who is uncomfortable with the elbow or shoulder, the body is not a joint. Since the entire arm has to be moved to insert the arm, this also has the problem of inconvenient measurement.

Therefore, there is an urgent need to develop a blood pressure measuring device that minimizes discomfort of an examinee in measuring blood pressure and precisely measures it in a simple manner.

An object of the present invention is to enable blood pressure measurement through the piezoelectric effect of a piezoelectric substance on a pulse, and at the same time, clearly define a relationship between a voltage signal and blood pressure due to the piezoelectric effect, a pulse sensing module for improving the accuracy of blood pressure measurement, blood pressure It is to provide a calculation module, a blood pressure measuring device, and a manufacturing method of a pulse sensing module.

The pulse sensing module according to an embodiment of the present invention is a module used in a blood pressure measuring device attached to the skin to measure at least one of systolic pressure, diastolic pressure, and blood pressure change. A piezoelectric layer containing a piezoelectric material for generating a piezoelectric effect by-a first electrode line and a second electrode line formed spaced apart from each other on one surface of the piezoelectric layer; And being applied to the piezoelectric layer to protect the piezoelectric layer, enabling a polling process to apply a high voltage to the first electrode line and the second electrode line to improve the polarity of the piezoelectric material, and the first electrode line. And the second electrode line is a blood pressure calculating module of the blood pressure measuring device-the blood pressure calculating module calculates at least one of the systolic blood pressure, the diastolic blood pressure, and the blood pressure change amount using a voltage signal generated by the piezoelectric effect. It may be characterized in that it comprises a; to be electrically connected to the protective layer having an opening to expose a portion of the first electrode line and a portion of the second electrode line.

The opening of the pulse sensing module according to an embodiment of the present invention includes a first opening and a second opening formed at positions corresponding to the ends of the first electrode line and the ends of the second electrode line, respectively. It can be characterized as.

The protective layer of the pulse sensing module according to an embodiment of the present invention surrounds a region other than a partial region of the first electrode line exposed through the first opening among the entire regions of the first electrode line, and the A region other than a partial region of the second electrode line exposed through the second opening among the entire region of the second electrode line may be surrounded.

Pulse sensing module according to an embodiment of the present invention, the shape of the piezoelectric layer to maintain the bending module of the blood pressure measuring device-the bending module, the voltage for the pulse generated by the piezoelectric effect of the piezoelectric layer In order to improve the precision of the signal, it is possible to be bent so that the blood pressure measuring device adheres closely to the curved skin surface of the human body-an adhesion mediation layer bonded to the other surface of the piezoelectric layer to stably adhere to it It can be characterized by.

The attachment medium layer of the pulse sensing module according to an embodiment of the present invention may be bent to interlock with bending of the bending module, thereby blocking the separation of the piezoelectric layer from the bending module.

An apparatus for measuring blood pressure according to another embodiment of the present invention is a device that is attached to the skin to measure at least one of systolic pressure, diastolic pressure, and blood pressure change, a pulse sensing module; And a blood pressure calculation module for calculating at least one of the systolic blood pressure, the diastolic blood pressure, and the blood pressure change amount using a voltage signal generated by the piezoelectric effect, wherein the blood pressure calculation modules each include a pulse signal for a preset time. After extracting the maximum voltage value (V _Max ) and the minimum voltage value (V _Min ) of the voltage signal by the pulse sensing module corresponding to, based on this, at least one of the systolic blood pressure, the diastolic blood pressure and the blood pressure change amount It may be characterized in that to calculate.

The blood pressure calculation module of the blood pressure measuring apparatus according to another embodiment of the present invention, the maximum voltage average value (V _Max , which is the average value for the maximum voltage value (V _Max )) extracted from the voltage signal for each of the pulse signals, _Avg ) is calculated, and a voltage change average value (V _Avg ) which is an average value for the difference between the maximum voltage value (V _Max ) and the minimum voltage value (V _Min ) extracted from the voltage signal for each of the pulse signals is calculated. Thus, at least one of the systolic blood pressure, the diastolic blood pressure, and the blood pressure change amount may be calculated.

The blood pressure calculation module of the blood pressure measurement apparatus according to another embodiment of the present invention, based on the correlation based on big data analysis, the maximum voltage average value (V _Max , _Avg ) and the average voltage change amount (V) _Avg ) may be characterized by calculating the systolic blood pressure and the blood pressure change amount P from each.

Correlation between the maximum voltage average value (V _Max , _Avg ) and systolic blood pressure (P _systolic ) based on the big data analysis of the blood pressure measuring apparatus according to another embodiment of the present invention is as follows. It can be characterized as satisfactory.

<Conditional Expression 1>

Here, P _systolic is systolic blood pressure, V _Max and _Avg are average values of maximum voltage, and α and β are constants derived by big data analysis.

According to another embodiment of the present invention, the correlation between the average voltage change amount (V _Avg ) and the blood pressure change amount (P) based on the big data analysis of the blood pressure measurement device satisfies the following <Conditional Expression 2> It can be characterized as.

<Conditional Expression 2>

Here, P is the amount of blood pressure change, V _Avg is the average value of the voltage change, and γ and δ are constants derived by big data analysis.

The blood pressure calculating module of the blood pressure measuring apparatus according to another embodiment of the present invention may be characterized in that the blood pressure change amount P is subtracted from the systolic blood pressure P _systolic to calculate the diastolic blood pressure P _diastolic . have.

The blood pressure calculation module of the blood pressure measurement apparatus according to another embodiment of the present invention, a signal pre-processing unit for amplifying the amplitude of the voltage signal generated by the piezoelectric effect and filtering noise, and pre-processed by the signal pre-processing unit And a converting unit for converting and outputting the voltage signal digitally and a control unit for calculating at least one of the systolic blood pressure, the diastolic blood pressure, and the blood pressure change amount based on the voltage signal converted by the converting unit. can do.

The blood pressure measuring device according to another embodiment of the present invention includes: a bending module to which the pulse sensing module and the blood pressure calculating module are attached and bendable so that the blood pressure measuring device is closely attached to the curved skin surface of the human body; It may be characterized in that it further comprises.

According to the pulse sensing module according to the present invention, the blood pressure calculation module, the blood pressure measuring device and the manufacturing method of the pulse sensing module, blood pressure can be measured through the piezoelectric effect of the piezoelectric substance on the pulse, thereby providing convenience to the testee.

In addition, it is possible to improve the accuracy of blood pressure measurement by clearly defining the relationship between the voltage signal and the blood pressure due to the piezoelectric effect.

In addition, the blood pressure measuring device according to the present invention can be manufactured in a patch or band type to enable accurate blood pressure measurement despite the curved skin characteristics and human activities of the human body, and at the same time, the size can also be downsized to maximize the utilization width. .

1 is a schematic perspective view showing a blood pressure measuring device according to an embodiment of the present invention and a diagram for explaining a situation in which the blood pressure measuring device is worn on a wrist and used to measure blood pressure.
Figure 2 is a block diagram for explaining a blood pressure measuring device according to an embodiment of the present invention.
Figure 3 is a schematic perspective view showing a pulse sensing module according to the present invention.
Figure 4 is a flow chart for explaining the manufacturing method of the pulse sensing module according to the present invention.
5 to 13 are views for explaining a method of manufacturing a pulse sensing module according to the present invention.
14 is a block diagram for explaining a blood pressure calculation module according to the present invention.
15 is a voltage signal graph over time showing a state in which the voltage signal is amplified and filtered by the blood pressure calculation module according to the present invention.
16 is a graph for explaining a correlation between a maximum voltage average value (V _Max , _Avg ) and systolic blood pressure (P _systolic ) based on big data analysis.
17 is a graph for explaining a correlation between a voltage change average value (V _Avg ) and a blood pressure change amount (P) based on big data analysis.
18 is a flow chart for explaining a blood pressure measurement method by a blood pressure measurement device according to an embodiment of the present invention.

Hereinafter, specific embodiments of the present invention will be described in detail with reference to the drawings. However, the spirit of the present invention is not limited to the presented embodiments, and a person skilled in the art who understands the spirit of the present invention may add another component within the scope of the same spirit, change, delete, etc. Other embodiments that are included within the scope of the invention idea can be easily proposed, but this will also be included within the scope of the invention.

In addition, elements having the same functions within the scope of the same idea appearing in the drawings of the respective embodiments will be described using the same reference numerals.

1. Overview of blood pressure measuring device

1 is a schematic perspective view showing a blood pressure measuring device according to an embodiment of the present invention and a diagram for explaining a situation in which the blood pressure measuring device is worn on a wrist and used to measure blood pressure, and FIG. 2 is an embodiment of the present invention It is a block diagram for explaining a blood pressure measurement device according to an example.

1 and 2, the blood pressure measuring apparatus 100 according to an embodiment of the present invention is attached to the skin so that at least one of systolic pressure (systolic pressure), diastolic pressure (diastolic pressure) and blood pressure change is measured As a device, it may be embodied as a patch type or a band type attached to a place in the human body where a pulse can be detected.

The blood pressure measuring device 100 may be implemented in a band type that can be worn on a wrist as shown in FIG. 1 (b), hereinafter, for example, when the blood pressure measuring device 100 is implemented in a band type. Listen and explain.

The blood pressure measuring device 100 may measure blood pressure using a voltage signal generated due to mechanical pressure caused by the pulse, and may include a pulse sensing module 110 for realizing such a piezoelectric effect.

The pulse sensing module 110 may sense a pulse signal of an examinee to generate a voltage signal corresponding to the pulse signal, and the voltage signal is amplified, filtered, and digitized to achieve systolic pressure and diastolic blood pressure. pressure) and blood pressure.

The above process for the voltage signal may be performed by the blood pressure calculation module 120, and the blood pressure calculation module 120 may be electrically connected to the pulse sensing module 110 for analysis of the voltage signal. have.

The blood pressure calculation module 120 may calculate systolic blood pressure, diastolic blood pressure, and changes in blood pressure from the voltage signal through a conditional expression derived based on big data analysis.

Meanwhile, the blood pressure measurement device 100 may include a battery module 130 for driving the blood pressure calculation module 120.

The battery module 130 may include a battery such as a lithium battery capable of supplying power and capable of charging or discharging, but is not limited thereto, and any battery capable of driving the blood pressure calculation module 120 It is applicable.

The battery module 130 may include a component for charging the battery, and may include, for example, a charging IC for constant current charging.

In addition, the battery module 130 may include a boosting circuit and a converting circuit for realizing it when it is necessary to boost or decompress the output voltage of the battery for driving the blood pressure calculating module 120.

For example, when the output voltage of the battery requires a driving voltage of 3V or 5V, the battery module 130 may include a boosting circuit for boosting 3V to 5V and a converting circuit for converting 5V to -5V. will be.

On the other hand, the blood pressure measuring device 100 may be implemented as a patch or band type as described above and attached to a place where a pulse can be detected. When the place to be attached is a curved skin surface, the accuracy of blood pressure measurement is improved. It may include a bending module 140 that is bendable to be adhered to a curved skin surface.

The pulse sensing module 110, the blood pressure calculation module 120 and the battery module 130 may be attached to the bending module 140, and the bending module 140 is configured to support the components. It can be an element.

The bending module 140 may be formed of a rubber material, a synthetic material, or the like having flexibility and flexibility that can bend to wrap around the wrist. For example, the bending module 140 may include polyimide, poly It may be implemented as an ester (polyester).

In addition, the bending module 140 may be formed of a material having a predetermined elasticity and having a property of returning to its original state.

The pulse sensing module 110 and the blood pressure calculation module 120 may have a predetermined flexibility as in the bending module 140, whereby the blood pressure measuring device 100 according to the present invention is subject to a piezoelectric effect. Since the accuracy of the voltage signal can be improved, the accuracy of blood pressure measurement can be maximized.

Meanwhile, FIG. 1 (a) shows that the blood pressure measuring apparatus 100 according to the present invention is provided with an outer appearance by a flexible cover, but the cover is not necessarily an essential component, and the bending module 140 It may be provided, it may be implemented so that at least one of the pulse sensing module 110, the blood pressure calculation module 120 and the battery module 130 is exposed.

Hereinafter, the pulse sensing module 110 and the blood pressure calculating module 120, which are components for measuring blood pressure by the blood pressure measuring apparatus 100, will be described in detail.

2. Pulse sensing module and its manufacturing method

Figure 3 is a schematic perspective view showing a pulse sensing module according to the present invention, Figure 4 is a flow chart for explaining a method of manufacturing a pulse sensing module according to the present invention, Figures 5 to 13 are pulse sensing modules according to the present invention It is a figure for explaining the manufacturing method of.

First, referring to FIG. 3, the pulse sensing module 110 according to the present invention is a component for generating a voltage signal due to mechanical pressure by a pulse, and includes a piezoelectric layer 112 and a protective layer 114 can do.

The piezoelectric layer 112 may be a piezoelectric thin film made of a piezoelectric material for generating a piezoelectric effect due to a pulse, and a first electrode line 116a and a second electrode spaced apart from each other on one surface of the piezoelectric layer 112. The electrode line 116b may be formed as a pattern.

The protective layer 114 is applied to the piezoelectric layer 112 to protect the piezoelectric layer 112, a part of the first electrode line 116a and the second electrode line 116b It may include openings (114a, 114b) to expose a portion of the region.

The openings 114a and 114b enable a polling process to apply a high voltage to the first electrode line 116a and the second electrode line 116b to improve the polarity of the piezoelectric material, and the first electrode line The 116a and the second electrode lines 116b may be electrically connected to the blood pressure calculation module 120.

The openings 114a and 114b are formed at positions corresponding to ends of the first electrode line 116a and ends of the second electrode line 116b, respectively, and the first opening 114a and the second opening 114b are formed. It may include.

The protective layer 114 may be embodied as an epoxy that can be cured by ultraviolet (UV), for example, SU-8 series negative consisting of Bisphenol A Novolacs (phenol-formaldehyde) -based Expoy can be photoresist.

The protective layer 114 surrounds a region other than a partial region of the first electrode line 116a exposed through the first opening 114a among the entire region of the first electrode line 116a. A region other than a partial region of the second electrode line 116b exposed through the second opening 114b among the entire region of the two electrode lines 116b may be surrounded.

Meanwhile, the pulse sensing module 110 is bonded to the other surface of the piezoelectric layer 112 so that the shape of the piezoelectric layer 112 is maintained to stably adhere to the bending module 140 of the blood pressure measuring device 100. It may include an adhesion medium layer (118).

The adhesion media layer 118 may be implemented with poly (ethyl benzene-1,4-dicarboxylate) or PEN (polyethylene naphthalate), which is generally a transparent plastic substrate.

The adhesion medium layer 118 may be attached to the other surface of the piezoelectric layer 112 via a bonding layer 119, and can be bent to interlock with the bending of the bending module 140 so that the piezoelectric layer 112 ) May be separated from the bending module 140.

The bonding layer 119 may be, for example, a NOA (Norland Optical Adhesive) solution product that is cured by ultraviolet light (UV), and may be implemented by coating with spin coating.

Here, the blood pressure measuring device 100 is implemented in a patch type or a band type and can be attached to a place where a pulse can be detected. The bending module 140 has flexibility and flexibility even when the place to be attached is a curved skin surface. By this, it can be brought into close contact with the curved skin surface.

In this case, since the attachment media layer 118 is also flexible and can be bent, it can be interlocked and bent when the bending module 140 is bent, whereby the adhesion media layer 118 is separated from the bending module 140. Being able to be prevented can be prevented, in the end, the piezoelectric layer 112 can be prevented from being separated from the bending module 140.

Hereinafter, a method of manufacturing the pulse sensing module 110 will be described.

4, the manufacturing method of the pulse sensing module 110 is a first step (S10) of forming a piezoelectric layer 112 using a piezoelectric material on one surface of the sacrificial substrate 200, the sacrificial substrate ( The second step (S20) of separating the 200) from the piezoelectric layer 112, so that the shape of the piezoelectric layer 112 is maintained so as to be stably attached to the bending module 140 of the blood pressure measuring device 100, A third step (S30) of forming the adhesion medium layer 118 on one surface of the piezoelectric layer 112 from which the sacrificial substrate 200 is separated, a first disposed spaced apart from each other on the other surface of the piezoelectric layer 112 The first step S40 of forming the electrode lines 116a and the second electrode lines 116b and the piezoelectric layer 112 are protected so that the first electrode lines 116a and the second electrode lines 116b are protected. A fifth step (S50) of forming the protective layer 114 on the other surface of the formed piezoelectric layer 112 may be included.

Here, the first step (S10) may include a step (S12) of forming a stress relief layer (300, S12) and a step of forming a temporary substrate layer 400 (S14), the fourth Step (S40) is a step of removing the stress reducing layer 300 and the temporary substrate layer 400 that is performed before forming the first electrode line 116a and the second electrode line 116b (S42). It may include.

Meanwhile, in the manufacturing method of the pulse sensing module 110, a polling process in which a high voltage is applied to the first electrode line 116a and the second electrode line 116b in order to improve the polarity of the piezoelectric material is performed. Step S60 may be further included.

Hereinafter, each step will be described in detail with reference to FIGS. 5 to 13, and it is revealed that the drawings are exaggerated for convenience of description.

Referring to FIG. 5, first, a first step S10 of forming a piezoelectric layer 112 as a piezoelectric thin film using a piezoelectric material on one surface of the sacrificial substrate 200 may be performed.

The sacrificial substrate 200 may be made of quartz or sapphire, which is transparent and can withstand high-temperature heat treatment, and to form the piezoelectric layer 112 by growing a piezoelectric thin film using a piezoelectric material It may be a necessary component.

For example, the sacrificial substrate 200 may be implemented as Al ₂ O ₃ based sapphire having a structure similar to the crystal structure of the piezoelectric thin film for growth of the piezoelectric thin film.

The piezoelectric material has a perovskite structure, and may be a material such as lead zirconate titanate (PZT), but is not limited thereto.

As a method of forming the piezoelectric layer 112, which is a piezoelectric thin film using the piezoelectric material, various known methods can be applied, for example, DC / RF sputtering, aerosol deposition, sol-gel solution process (after spin coating. Heat treatment), screen / inkjet printing, and the like.

The sacrificial substrate 200 may be separated from the piezoelectric layer 112, which is a piezoelectric thin film, by a laser lift-off (LLO) method when the second step S20 is performed, and for this purpose, a transparent substrate through which light can be transmitted. Can be implemented as

Referring to FIG. 6, after the piezoelectric layer 112 is formed on one surface of the sacrificial substrate 200, the sacrificial substrate (to relieve stress due to at least one of high temperature, high pressure, and impact that may occur in a subsequent step ( A step (S12) of forming a stress reducing layer 300 on the other surface of the piezoelectric layer 112 on which the 200 is formed may be performed.

The stress reducing layer 300 is the piezoelectric thin film 112, which is a piezoelectric thin film when the second step (S20) of removing the sacrificial substrate 200 is caused by mechanical, physical, and thermal stress due to high temperature, high pressure, and shock. Due to this, structural or material deformation such as cracks or wrinkles may occur, and thus may be a component for preventing the reduction of piezoelectric characteristics or inaccuracy of the output voltage.

The stress reducing layer 300 may be Bisphenol A Novolacs (phenol-formaldehyde) -based Epoxy, which is an epoxy-based curing agent for ultraviolet light (UV), and may have a thickness of 500 nm or more.

Referring to FIG. 7, when the stress reducing layer 300 is formed, forming a temporary substrate layer 400 on one surface of the stress reducing layer 300 for handling the piezoelectric layer 112 in a subsequent step ( S14) may proceed.

After the temporary substrate layer 400 is a second step (S20), which is a subsequent step, and the sacrificial substrate 200 is separated from the piezoelectric layer 112, the thickness of the entire layer excluding the temporary substrate layer 400 is It is about a few μm, and it is virtually impossible to handle the piezoelectric layer 112, which is a piezoelectric film thin film, when performing the steps after the second step (S20) with only this thickness without the temporary substrate layer 400. It is necessary.

Of course, forming the stress reducing layer 300 as a single layer capable of simultaneously implementing the function of the stress reducing layer 300 and the function of the temporary substrate layer 400 (S12) and the temporary substrate layer 400 The step of forming (S14) may be performed as one step.

The temporary substrate layer 400 may be made of a material that can be removed by heat or ultraviolet (UV).

For example, the temporary substrate layer 400 may be a tape in which a thermally expandable adhesive or an ultraviolet (UV) energy beam expandable adhesive is applied on one side or both sides, and the adhesive is easily applied by heat or ultraviolet (UV). It can have the property of being vaporized by expansion.

The adhesive has a structure in which spherical or other types of particles are included in the matrix material, and the matrix material is polyvinyl alcohol, polyvinyl butyral, polyacrylonitrile, As a thermoplastic material such as polysulfone, it may have a property of being melted and expanded by heat and burst, and particles present therein have structures such as isobutene, propane, or pentane As a thermally expandable particle having, about 500 nm to 100 μm is preferred, and may be a single or a combination of at least two or more.

The adhesive may be applied to one side or both sides of the tape, and the thickness of the temporary substrate layer 400 may be, for example, 1 to 500 μm.

Referring to FIG. 8, after the stress reduction layer 300 and the temporary substrate layer 400 are formed through the first step (S10), the second step of separating the sacrificial substrate 200 from the piezoelectric layer 112. (S20) may proceed.

The method of separating the sacrificial substrate 200 from the piezoelectric layer 112 may be a mechanical peeling method, a chemical etching method, or a laser lift off (LLO) method described above.

For example, when the method of separating the sacrificial substrate 200 from the piezoelectric layer 112 is a laser lift off (LLO) method, the sacrificial substrate 200 is implemented as a transparent substrate through which light can be transmitted. , It may be removed by the light energy transmitted through the transparent substrate.

Referring to FIG. 9, the shape of the piezoelectric layer 112 is maintained so that the sacrificial substrate 200 is separated from the piezoelectric layer 112 so as to be stably attached to the bending module 140 of the blood pressure measurement device 100. A third step (S30) of forming an adhesion mediator layer 118 on one surface may be performed.

The adhesion medium layer 118 may be attached to the other surface of the piezoelectric layer 112 via the bonding layer 119.

The bonding layer 119 may be, for example, a NOA (Norland Optical Adhesive) solution product that is cured by ultraviolet light (UV), and may be implemented by coating with spin coating.

The attachment media layer 118 may be flexible and bendable, and thus, when the blood pressure measuring device 100 is attached to and attached to a curved skin surface for blood pressure measurement, the bending module 140 having flexibility and flexibility By being interlocked with the bending of the bend, it can be prevented that the adhesion medium layer 118 is separated from the bending module 140, and in the end, the piezoelectric layer 112 is separated from the bending module 140. It can be prevented.

10 and 11, a fourth step (S40) of forming the first electrode line 116a and the second electrode line 116b formed to be spaced apart from each other on the other surface of the piezoelectric layer 112 may be performed. .

Here, as shown in FIG. 10, removing the stress reducing layer 300 and the temporary substrate layer 400 before forming the first electrode line 116a and the second electrode line 116b ( S42) may be performed, which may be performed through a process of applying heat or ultraviolet light (UV).

When the heat or ultraviolet (UV) is applied, the adhesive included in the temporary substrate layer 400 expands and vaporizes, resulting in weak adhesion, and then the stress reducing layer 300 and the temporary through physical peeling operation. The substrate layer 400 may be removed.

Here, since the stress reducing layer 300 is already cured, an increase in adhesion with other layers does not occur even when heat or ultraviolet (UV) is applied, and the temporary substrate layer 400 has heat and ultraviolet (UV). Even when the adhesive component expands and vaporizes by applying this, the adhesive force remaining to be separated through a physical peeling operation remains.

The adhesion strength of the temporary substrate layer 400 to the extent of being separated through a physical peeling operation is greater than the adhesion strength of the stress reducing layer 300 adhered to the piezoelectric layer 112 so that the physical adhesion to the temporary substrate layer 400 is performed. During the phosphorus peeling operation, the stress reducing layer 300 may also be removed at the same time.

However, the removal of the stress reduction layer 300 and the removal of the temporary substrate layer 400 are not necessarily performed simultaneously, and may be sequentially performed.

As illustrated in FIG. 10, after the stress reduction layer 300 and the temporary substrate layer 400 are removed, as illustrated in FIG. 11, the first electrodes are spaced apart from each other on the other surface of the piezoelectric layer 112. The lines 116a and the second electrode lines 116b are formed.

The first electrode line 116a and the second electrode line 116b may be formed in a pattern through a known semiconductor process after coating the electrode material.

The first electrode line 116a and the second electrode line 116b may each include a plurality of parallel lines arranged parallel to each other, but the arrangement form of the lines may be variously changed.

Referring to FIG. 12, after the first electrode line 116a and the second electrode line 116b are formed, the first electrode line 116a and the second electrode line ( A fifth step (S50) of forming the protective layer 114 on the other surface of the piezoelectric layer 112 on which 116b) is formed may be performed.

The protective layer 114 may include a first opening 114a and a second opening 114b to expose an end of the first electrode line 116a and an end of the second electrode line 116b.

Here, the exposed end of the first electrode line 116a and the end of the second second electrode line 116b may enable a polling process performed in a subsequent step, and a blood pressure calculation module for blood pressure measurement ( 120) can be used as a component for electrical connection with.

Referring to FIG. 13, when formation of the protective layer 114 is completed, a polling process that applies a high voltage to the first electrode line 116a and the second electrode line 116b to improve the polarity of the piezoelectric material Step 6 (S60) may be performed.

The polling process is a process for imparting dipole orientation in a piezoelectric material, and may be performed by applying an electric field of a level of 100 kV / cm for at least 2 hours, but is not limited thereto.

As described above, the polling process in the sixth step (S60), that is, application of high voltage is enabled through the first opening 114a and the second opening 114b of the protective layer 114, and the pulse sensing module 110 ) While sufficiently protecting the physically sufficient polarity efficiency of the piezoelectric layer 112.

In other words, when the high voltage is applied, if the protective layer 114 is not present, electricity is generated due to the electric field effect between the electrodes to cause the electrode to be disconnected, but in the present invention, the first opening ( It is possible to improve the polarity efficiency of the piezoelectric layer 112 by solving the above-described problem by canceling the electric field effect between electrodes due to the protective layer 114 having the 114a) and the second opening 114b. .

When the progress of the first step (S10) to the sixth step (S60) is completed as described above, the manufacture of the pulse sensing module 110 constituting the blood pressure measuring device 100 is completed.

3. Blood pressure calculation module

14 is a block diagram illustrating a blood pressure calculation module according to the present invention, and FIG. 15 is a voltage signal graph over time showing a state in which the voltage signal is amplified and filtered by the blood pressure calculation module according to the present invention.

In addition, FIG. 16 is a graph for explaining a correlation between a maximum voltage average value (V _Max , _Avg ) and systolic blood pressure (P _systolic ) based on big data analysis, and FIG. 17 is a voltage based on big data analysis It is a graph to explain the correlation between the average value of change (V _Avg ) and the amount of change in blood pressure (P).

First, referring to FIGS. 14 to 17, the blood pressure calculation module 120 according to the present invention uses systolic blood pressure, diastolic blood pressure, and diastolic blood pressure by using a voltage signal by a piezoelectric effect provided through an electrically connected pulse sensing module 110. It may be a module for calculating at least one of blood pressure changes.

The blood pressure calculation module 120 may basically include a flexible printed circuit board, and a chip or the like performing a function described below may be mounted on the flexible printed circuit board or the circuit may be patterned.

The flexible printed circuit board may be attached to the bending module 140, whereby when the blood pressure measuring device 100 is closely attached to the curved skin surface for blood pressure measurement, the bending module 140 having flexibility and flexibility ) Can be bent in conjunction with bending.

The electrical connection between the pulse sensing module 110 and the blood pressure calculation module 120 is of the first electrode line 116a exposed through the first opening 114a and the second opening 114b of the protective layer 114. The end and the end of the second electrode line 116b may be implemented by interconnecting a terminal of the flexible printed circuit board using a conductive material, and the conductive material may be preferably a metallic material having a resistance of 10 Ω or less.

On the other hand, the blood pressure calculation module 120 receives the voltage signal provided by the pulse sensing module 110, amplifies the amplitude of the voltage signal and filters the noise, a signal pre-processing unit 122 and the signal pre-processing unit 122 ) Of the systolic blood pressure, the diastolic blood pressure and the amount of blood pressure change based on the voltage signal converted by the converter 124 and the converter 124 for digitally converting and outputting the voltage signal preprocessed by). It may include a control unit 126 for calculating at least one.

Here, the signal pre-processing unit 122 may include an amplifying unit 122a and a filtering unit 122b, and the amplifying unit 122a may amplify the voltage signal provided by the pulse sensing module 110. In addition, the filtering unit 124b may filter noise included in the amplified voltage signal.

15 illustrates a graph of a voltage signal over time in a state in which a voltage signal generated due to mechanical pressure by a pulse is amplified by the amplifying unit 122a and noise is filtered by the filtering unit 122b.

The converting unit 124 is a component that converts a voltage signal amplified by the amplifying unit 122a and filtered by noise by the filtering unit 122b, and converts the voltage signal from analog to digital to control the unit 126 ) May be an A / D conversion unit that outputs in the form of a recognizable voltage signal.

Meanwhile, the control unit 126 may calculate at least one of the systolic blood pressure, the diastolic blood pressure, and the blood pressure change amount based on the digitally converted voltage signal through the conversion unit 124. Explain.

When an examinee wears the blood pressure measuring device 100 on the wrist and requests blood pressure measurement, the pulse sensing module 110 responds to the pulse signal for a preset time and calculates a voltage signal according to the piezoelectric effect. It transmits to the module 120.

Here, the predetermined time may be 15 seconds as shown in FIG. 15, for example, but is not limited thereto, and may be variously changed.

The control unit 126 may extract a maximum voltage value (V _Max ) and a minimum voltage value (V _Min ) of a voltage signal corresponding to each pulse signal during the preset time period, and thereafter, for each of the pulse signals, calculating the said maximum voltage value (V _max) the maximum voltage average value (V _{max, Avg)} the average value for the extracted from the voltage signal, and the maximum voltage extracted from the voltage signal for each of the pulse signal (V _max) And the average voltage change amount (V _Avg ), which is an average value for the difference between the and the minimum voltage value (V _Min ).

<Conditional Expression 1> and <Conditional Expression 2> for calculating the average value of the maximum voltage (V _Max , _Avg ) and the average value of the voltage change (V _Avg ) are as follows.

<Conditional Expression 1>

<Conditional Expression 2>

Here, n is the number of pulse signals and may be 16 in the case of FIG. 15.

After calculating the maximum voltage average value (V _Max , _Avg ) and the average voltage change amount (V _Avg ) through the <Conditional Expression 1> and the <Conditional Expression 2>, the controller 126 correlates based on big data analysis. On the basis of, the systolic blood pressure (P _systolic ) and the blood pressure change amount (P) are calculated from each of the maximum voltage average value (V _Max , _Avg ) and the average value of the voltage change (V _Avg ).

Here, by comparison a relationship between the systolic blood pressure (P _systolic) Big Data analysis for calculating the average maximum of the collected and stored examinee with big data type information voltage (V _{Max, Avg)} and systolic blood pressure (P _systolic) It may be obtainable, and FIG. 16 shows a correlation between the maximum voltage average value (V _Max , _Avg ) and systolic blood pressure (P _systolic ) by big data analysis for a normal person.

Referring to FIG. 16, in the case of a normal person, the correlation between the maximum voltage average value (V _Max , _Avg ) and systolic blood pressure (P _systolic ) by big data analysis is as follows.

<Conditional Expression 3>

V _Max , _Avg = 2.20113 * 10 ^-4 * P _systolic + 0.0033

Therefore, when <Conditional Expression 3> is generalized, the correlation between the maximum voltage average value (V _Max , _Avg ) and systolic blood pressure (P _systolic ) can be generalized to <Conditional Expression 4> below.

<Conditional Expression 4>

Here, P _systolic is systolic blood pressure, V _Max and _Avg are maximum voltage average values, α and β are constants derived by big data analysis, and in normal people, α is 2.20113 * 10 ^-4 and β is 0.0033.

In addition, the big data analysis for calculating the blood pressure change amount P can be obtained by comparing and analyzing the relationship between the average voltage change amount V _Avg and the blood pressure change amount P among the information collected and stored in the form of big data. , FIG. 17 shows the correlation between the average value of voltage change (V _Avg ) and the change in blood pressure (P) by analyzing big data for normal people.

Referring to FIG. 17, in the case of a normal person, the correlation between the average voltage change amount (V _Avg ) and the blood pressure change amount (P) by big data analysis is as follows.

<Conditional Expression 5>

P (mmHg) = -2196.83 * V _Avg (mV) + 106.82125

Therefore, when <Conditional Expression 5> is generalized, the correlation between the average value of the voltage change amount V _Avg and the blood pressure change amount P can be generalized to the following <Conditional Expression 6>.

<Conditional Expression 6>

Here, P is the change in blood pressure, V _Avg is the average value of the change in voltage, γ and δ are constants derived by big data analysis. In normal people, γ is 2196.83 and δ is 106.82125.

On the other hand, α, β, γ and δ used in <Conditional Expression 4> and <Conditional Expression 6> may vary depending on the characteristics of the subject collected and stored in the form of big data, for example, hypertension, hypotension, disease group, age, It may be a constant that can vary depending on gender.

The controller 126 may calculate the diastolic blood pressure (P _diastolic ) by subtracting the blood pressure change amount (P) from the systolic blood pressure (P _systolic ) as shown in <Conditional Expression 7> below.

<Conditional Expression 7>

As described above, the blood pressure calculation module 120 according to the present invention amplifies and filters the voltage signal by the piezoelectric effect provided through the electrically connected pulse sensing module 110, converts it to digital, and performs a series of processing. Finally, systolic blood pressure and diastolic blood pressure are calculated so that the blood pressure of the subject can be measured.

In addition, the blood pressure is _{measured using} the correlation between the maximum voltage average value (V _Max , _Avg ) and systolic blood pressure (P _systolic ) and the voltage change average value (V _Avg ) and the blood pressure change (P) derived by big data analysis. Since it is measured, the accuracy of blood pressure measurement can be improved.

Since the blood pressure measuring apparatus 100 according to an embodiment of the present invention may be implemented in a patch type or a band type that can be attached to the skin, it can provide convenience to an examiner and an examinee in measuring blood pressure.

Meanwhile, the blood pressure measuring apparatus 100 according to the present invention may further include a display module that displays systolic blood pressure and diastolic blood pressure calculated by the controller 126.

In addition, the blood pressure measuring apparatus 100 according to the present invention may further include a device interface for supporting interfacing with an external device, so that the systolic blood pressure and diastolic blood pressure calculated by the control unit 126 are displayed through an external device. have.

4. A blood pressure measuring method using a blood pressure measuring device and a recording medium recording a program for executing the method

18 is a flowchart illustrating a blood pressure measurement method using a blood pressure measurement device according to an embodiment of the present invention.

Referring to FIG. 18, a blood pressure measurement method using a blood pressure measurement device according to an embodiment of the present invention may include a pulse sensing module 110 when an examinee wears the blood pressure measurement device 100 on a wrist and requests blood pressure measurement ) Is a first step (S100) of sensing the pulse signal for a predetermined time and generating a voltage signal according to the piezoelectric effect, the maximum voltage value (V _Max ) and the minimum of the voltage signal corresponding to each pulse signal during the preset time The second step (S200) of extracting the voltage value (V _Min ), the maximum voltage average value (V _Max , _Avg ) which is the average value for the maximum voltage value (V _Max ) extracted from the voltage signal for each of the pulse signals is A third step of calculating a voltage change average value (V _Avg ) which is an average value for a difference between the maximum voltage value (V _Max ) and the minimum voltage value (V _Min ) extracted from the voltage signal for each of the pulse signals. Step S300, based on the correlation based on big data analysis, the systolic blood pressure (P _systolic ) and the blood pressure change amount from each of the maximum voltage average value (V _Max , _Avg ) and the average voltage change amount (V _Avg ), respectively. The fourth step (S400) for calculating (P), the fifth step (S500) for calculating the diastolic blood pressure (P _diastolic ) by subtracting the blood pressure change amount (P) from the systolic blood pressure (P _systolic ) and the calculated result value It may include a sixth step (S600) for outputting.

Here, the second step (S200) to the fifth step (S500) may be performed by the control unit 126 of the blood pressure calculation module 120, and the sixth step (S600) may be performed by a display module or an external device. You can.

Then, prior to the second step (S200), a step of amplifying and filtering the voltage signal by the piezoelectric effect provided through the pulse sensing module 110, and then converting it to digital may proceed.

Meanwhile, each step of the blood pressure measurement method described above may be implemented as a computer-readable code on a computer-readable recording medium. The computer-readable recording medium includes all kinds of recording devices in which data readable by a computer system is stored. Examples of computer-readable recording media include ROM, RAM, CD-ROM, magnetic tapes, floppy disks, optical data storage devices, etc., which are also implemented in the form of carrier waves (for example, transmission over the Internet). Also includes. The computer-readable recording medium can also be distributed over network coupled computer systems so that the computer readable code is stored and executed in a distributed fashion.

In the above, the configuration and features of the present invention have been described based on the embodiments according to the present invention, but the present invention is not limited to this, and various modifications or changes can be made within the spirit and scope of the present invention. It is apparent to those skilled in the art, and thus, such changes or modifications are found to be within the scope of the appended claims.

100: blood pressure measuring device
110: pulse sensing module
120: blood pressure calculation module
130: battery module
140: bending module

Claims (13)

In the pulse sensing module used in the blood pressure measuring device attached to the skin to measure at least one of systolic pressure (systolic pressure), diastolic pressure (diastolic pressure) and blood pressure change,
A piezoelectric layer containing a piezoelectric material for generating a piezoelectric effect due to a pulse, wherein a first electrode line and a second electrode line are spaced apart from each other on one surface of the piezoelectric layer; And
It is applied to the piezoelectric layer to protect the piezoelectric layer,
In order to improve the polarity of the piezoelectric material, a polling process of applying a high voltage to the first electrode line and the second electrode line is possible,
The first electrode line and the second electrode line are blood pressure calculation modules of the blood pressure measurement device-the blood pressure calculation module uses the voltage signal generated by the piezoelectric effect to reduce the systolic blood pressure, the diastolic blood pressure, and the blood pressure change amount So that at least one of them is calculated-to be electrically connected to,
And a protective layer having an opening through which a partial area of the first electrode line and a partial area of the second electrode line are exposed.
According to claim 1,
The opening,
And a first opening and a second opening formed at positions corresponding to ends of the first electrode line and ends of the second electrode line, respectively.
According to claim 1,
The protective layer,
The entire area of the first electrode line is surrounded by an area other than a partial area of the first electrode line exposed through the first opening, and the entire area of the second electrode line is exposed through the second opening. A pulse sensing module, which encompasses an area other than a partial area of the second electrode line.
According to claim 1,
Bending module of the blood pressure measuring device so that the shape of the piezoelectric layer is maintained-the bending module is bendable so that the accuracy of the voltage signal for the pulse generated due to the piezoelectric effect of the piezoelectric layer is improved, thereby measuring the blood pressure Pulse attachment module, characterized in that it further comprises a; adhesion to the other surface of the piezoelectric layer to be stably attached to the device to be adhered to the curved skin surface of the human body.
The method of claim 4,
The adhesion medium layer,
Pulse sensing module, characterized in that it is possible to bend to interlock with the bending of the bending module to block the piezoelectric layer from being separated from the bending module.
In the blood pressure measuring device is attached to the skin to measure at least one of systolic pressure (systolic pressure), diastolic pressure (diastolic pressure) and blood pressure change,
The pulse sensing module according to claim 1; And
It includes; a blood pressure calculation module for calculating at least one of the systolic blood pressure, the diastolic blood pressure, and the blood pressure change amount using a voltage signal generated by the piezoelectric effect;
The blood pressure calculation module,
After extracting the maximum voltage value (V _Max ) and the minimum voltage value (V _Min ) of the voltage signal by the pulse sensing module corresponding to each pulse signal for a preset time, based on this, the systolic blood pressure, the diastolic blood pressure And a blood pressure change amount.
The method of claim 6,
The blood pressure calculation module,
The calculated cost to the maximum voltage value (V _Max) The maximum voltage average value (V _{Max, Avg)} the average value for the extracted from the voltage signal for each of the pulse signals, extracted from the voltage signal for each of the pulse signal Calculating at least one of the systolic blood pressure, the diastolic blood pressure, and the blood pressure change amount by calculating a voltage change average value (V _Avg ) which is an average value for the difference between the maximum voltage value (V _Max ) and the minimum voltage value (V _Min ) Blood pressure measuring device, characterized in that.
The method of claim 7,
The blood pressure calculation module,
On the basis of the correlation based on big data analysis, the systolic blood pressure and the blood pressure change amount (P) are calculated from each of the maximum voltage average value (V _Max , _Avg ) and the average voltage change amount (V _Avg ). Blood pressure measuring device.
The method of claim 8,
The correlation between the maximum voltage average value (V _Max , _Avg ) and systolic blood pressure (P _systolic ) based on the big data analysis is:
Blood pressure measuring device, characterized in that satisfy the following <Condition 1>.

<Conditional Expression 1>

Here, P _systolic is systolic blood pressure, V _Max and _Avg are average values of maximum voltage, and α and β are constants derived by big data analysis.
The method of claim 9,
The correlation between the average voltage change amount (V _Avg ) and the blood pressure change amount (P) based on the big data analysis is:
Blood pressure measuring device, characterized in that it satisfies the following <Condition 2>.

<Conditional Expression 2>

Here, P is the amount of blood pressure change, V _Avg is the average value of the voltage change, and γ and δ are constants derived by big data analysis.
The method of claim 10,
The blood pressure calculation module,
Blood pressure measuring device, characterized in that by calculating the diastolic blood pressure (P _diastolic ) by subtracting the amount of blood pressure change (P) from the systolic blood pressure (P _systolic ).
The method of claim 6,
The blood pressure calculation module,
A signal pre-processing unit for amplifying the amplitude of the voltage signal generated by the piezoelectric effect and filtering noise, a conversion unit for digitally converting the voltage signal pre-processed by the signal pre-processing unit, and outputting the converted digital signal And a control unit calculating at least one of the systolic blood pressure, the diastolic blood pressure, and the blood pressure change amount based on the voltage signal.
The method of claim 6,
The pulse sensing module and the blood pressure calculation module is attached, it is possible to bend the blood pressure measurement device, characterized in that it further comprises a bending module to be attached to the curved skin surface of the human body.

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