KR20200044682A - Bio-Marker Composition for Sensitivity Prediction of IGFR Drug, Estimation Method for Sensitivity Prediction of IGFR Drug using Bio-Marker Composition and Diagnosing Chip for Detection of Bio-Marker Composition for Sensitivity Prediction of IGFR Drug - Google Patents

Abstract

The present invention relates to a biomarker composition for evaluating IGFR drug responsiveness using cancer biomarker labeling scan (GBLscan), which is a new learning model capable of predicting haplotype biomarker containing IGFR drug responsiveness functional information, thereby enabling a reliable prediction and drug labeling IGFR drug responsiveness. In particular, the present invention relates to a biomarker composition consisting a combination of markers containing mutations regulating gene expressions for evaluation responsiveness with respect to IGFR drugs, wherein the biomarker composition comprises X_119618658_T_G (Marker 1) and 1_16148437_A_C (Marker 2). According to the present invention, the biomarker composition enables the prediction of sensitivity to IGFR drugs by subject′s genotype by means of biomarkers to IGFR-related drugs, and thus can enable an effective preliminary testing not only in the field of personalized medicine, but also in screening of new drug candidates.

Description

Biomarker Composition for Sensitivity Prediction of IGFR Drug, Estimation Method for Sensitivity Prediction of IGFR Drug using Bio-Marker Composition and Diagnosing Chip for Detection of Bio-Marker Composition for Sensitivity Prediction of IGFR Drug}

The present invention relates to a haplotype biomarker comprising gene expression information for predicting the reactivity of an IGFR cancer drug and functional information using a cloned variable (CNV), so that IGFR drug reactivity can be predicted reliably. It relates to a biomarker composition for determining the IGFR drug reactivity.

Recent advances in next-generation sequencing (NGS) technology have made many advances in understanding complex and diverse cancers. In addition, an international consortium effort has developed and published a catalog of somatic mutations in these cancer species as well as an overall database of driver mutations (see Prior Art Document 001).

The results of this international consortium study have also led to a rapid growth in cancer-specific treatment for specific genomic fingerprints of individual tumors.

However, new customized cancer treatments that are approved and used clinically are still insufficient for all stakeholders in the medical industry, including cancer patients and the pharmaceutical industry (see Prior Art Document 002). Therefore, there is a need for an efficient and systematic approach to predicting the association for personalization between genomic information and the response of anticancer drugs.

In addition, several collaborative consortia have been conducted to integrate molecular profiling data of cancer cell lines and drug toxicity data [see www.lincsproject.org, prior art document 003]. The consortium's most important goal is to identify genomic biomarkers that can predict anti-cancer drug toxicity and personalized drugs.

Among the cell line genome DBs for drug toxicity in cancer, GDSC (Gnomics of Drug Sensitivity in Cancer) is one example of a publicly available database. In particular, GDSC is a public database that experimentally measures drug toxicity information of 1,070 human cancer cells against 265 anti-cancer compounds (see Prior Art Document 004).

The GDSC cell line project used here was published at the following site (CCLP: COSMIC Cell Lines Project, http://cancer.sanger.ac.uk/cell_lines). It is expected that these common resources will help in realizing genome-based precision cancer treatment.

However, despite the potential value of these databases, due to the high level of data and complexity, there are many technical problems with integrated analysis. Thus, although many computational methods have been developed to systematically characterize molecular biomarkers in anti-cancer drug toxicity (see prior art document 003), despite these efforts, drug toxicity is limited to a particular cell line and a given set of genetic variations, all of which are This is because human genetic information is different, and common mutations are only part of the whole.

With the recent development of information technology, a method increasingly used to solve the above-mentioned complex problems is called a deep learning model or a deep learning model (see Prior Art Document 005). Deep learning learning method is a field of deep machine learning from a large amount of high-dimensional raw data.

Until recently, there were many limitations directly to the amount of computation to train, but you can train deep learning learning models with various layers containing thousands of hidden units while using methodological improvements and powerful machines with parallel computing. It became available [refer to prior technical document 006].

On the other hand, since it is possible to manipulate various types of structural information such as pharmacological, genomic, transcript and epigenetic data and their drug reactivity data, it is suitable for predicting drug-target interactions with minimal guidance [see Prior Art Document 005] ].

The pharmaceutical industry is beginning to show great expectations for deep learning learning that uses this type of data to develop new drugs. Some promising results have recently been demonstrated using artificial intelligence in drug development [see prior art document 007], and drug repositioning with superior predictive accuracy compared to drug-target profiles and other traditional machine learning models is also possible. Got done However, the majority of approaches are more than just proof of concept, and a solution capable of producing drugs through deep learning is insufficient.

Currently, PubChem (pubchem.ncbi.nlm.nih.gov) is operated by the National Institute of Technology Information (NCBI) in the United States and provides information on about 100 million compounds, 200 million substances, and bioassay information. (En.wikipedia.org/wiki/PubChem).

In addition, there are many methods for expressing this compound as a pharmacophore descriptor (see prior art document 008). Among them, the Padel method can be expressed in 1,875 (1D and 2D 1,444, and 3D 431) features and 12 fingerprints (about 16,092 bits in total) in the drug (refer to prior art document 008).

And the variation in genome can extract various features. In particular, conventional methods for extracting a disease-causing mutation have been disclosed in various documents.

Therefore, in the prior art, QSAR (Quantitative structure activity relationship), drug development using drug cytotoxicity data, deep learning-based expression regulation of whole genome sequencing, structural variation, etc. are independently applied and utilized. Became.

In the present invention, however, CDR drug (Cancer drug response scanning), an AI deep learning method that integrates heterogeneous characteristic information (dielectric information, QSAR information, and expression information) into drug-cell lines-toxicity (IC50) data, Prediction accuracy has been significantly improved compared to previous computer modeling approaches, especially virtual drugs vs. We have proposed a model for the interaction of virtual cells (cell lines) or target proteins.

Here, the two different heterogeneous virtual information may be applied when the first is a drug, the methods disclosed in the Padell method or prior art documents 029 to 033.

And the second can be described as a literature method for the fingerprint (Genomic fingerprint, or a set of mutation features) of the full-length genome (or target protein), the most standard deep learning method is as disclosed in prior art document 009 .

Therefore, the method can be used in an accurate drug response prediction model and drug re-use / drug repositioning, screening of chemicals, discovering new anticancer drug candidates, and a clinical decision supporting system for selecting patient-specific anticancer drugs. .

In addition, a recent article on cancer drug reaction scan (CDRscan) related to re-use / drug repositioning was published by the head office (see Prior Art Document 010).

That is, a drug responsiveness study using expression information and biomarker information of drugs, target gene drugs, and target candidate genes given by gene expression and system statistical methods has recently been published.

Although there has been no research on the biomarker itself in this paper, the inhibition of the major drugs against major targets by using known gene biomarkers and expression information is inhibited by CCLE (Cancer Cell Line Encyclopedia), CTRP (Cancer Therapeutics) Response Portal, Broad) and some GDSCs were used to predict (CARE) and verify the results (see Prior Art Document 011).

In addition, many major studies have been published on eQTL (expression and Quantitative Trait Loci), that is, disease or phenotypic linkage between expression and genomic variation (see Prior Art Document 012). In addition, a number of major studies on the disease or phenotypic linkage between protein production and genomic variation, i.e.

However, studies on the relationship between drug response or drug phenotype between cQTL (Copy Number Variation and Quantitative Trait Loci), that is, copy number variation (CVV), which is an increase or decrease variation in drug responsiveness and gene copy number, and genomic variation, have not been published. none.

Therefore, in this method of genetic biomarker label scan (GBLscan), (a) eQTL (expression and Quantitative Trait Loci), that is, disease or phenotypic relationship between expression and genomic variation, (b) cQTL (Copy Number Variation and Quantitative Trait Loci), In other words, no reference exists for the relationship between copy amplification and copy deletion.

In the present invention, the definition of the drug type (DrugClass) is a type of drug targets and a functionally similar functional type of drug, or a gene group, drug pathway or drug signaling of a category in which the drug is affected. Pathway (drug signaling pathway), etc. are all described as one generic drug type (DrugClass). In addition, unlike the haplotypes of several locus that have been phasing in the gene, which is a commonly used haplotype, the functional subflow type is a human genome version of Dec. 2013 (GRCh38 / hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https: sorting the next-generation sequencing read (read) data based on the //www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 When done, information is read in genotype form at each gene locus. This type of genotype is expressed in the form of 1: homo, 2: hetero, or 3: alt home, and such a collection of genotypes can be called a relative halfrotype. And if the relative haplotype composed of a single or a combination of specific locus is related to the expression of a specific gene, it is defined in the present invention as a functional hypoprotype.

On the other hand, if the non-patent prior art documents attached below are divided into major contents, the non-patent documents,

(001-002) is a paper linking genomic information to the response of anticancer drugs;

(003-004) are cancer genome drug toxicity and COSMIC cell line project literature;

(005-006) are pharmacology and genome-related papers of the deep learning deep learning model;

(007) is a paper used to develop a new drug for deep learning deep learning model;

(008) is a method and paper for expressing drugs and mutations as features;

(009-010) is a paper on deep learning methodology and algorithms;

(011) is a drug re-creation or drug response prediction paper,

(012-013) are papers on eQTL and pQTL methodologies and algorithms.

(001) Forbes, S. A., et al. COSMIC: somatic cancer genetics at high-resolution. Nucleic Acids Research. 45, 777-783 (2017). (002) Williams SP, & McDermott U. The pursuit of therapeutic biomarkers with high-throughput cancer cell drug screens. Cell Chemical Biology. 24, 1066-1074 (2017). (003) Barretina, J, et al. The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity. Nature. 483, 603-7 (2012). (004) Yang, W., et al. Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Research. 41, 955-961 (2013). (005) Vanhaelen, Q., et al .. Design of efficient computational workflows for in silico drug repurposing. Drug Discovery Today. 22, 210-222 (2017). (006) Dahl, G. E., Jaitly, N. & Salakhutdinov, R. Multi-task neural networks for QSAR predictions. arXiv: 1406.1231 (2014). (007) Baskin, I.I., Winkler, D. & Tetko, I.V. A renaissance of neural networks in drug discovery. Expert Opinion on Drug Discovery. 11, 785-95 (2016). (008) Yap CW. PaDEL-Descriptor: An open source software to calculate molecular descriptors and fingerprints. Journal of Computational Chemistry. 32, 1466-1474 (2011) (009) Deep Learning: Yann Lecun, Y., Bengio, Y. & Hinton, G. Nature. 521, 436-444 (2015) (010) Cancer Drug Response Profile scan (CDRscan): A Deep Learning Model That Predicts Drug Effectiveness from Cancer Genomic Signature: Yoosup Chang, Scientific Report ,. 8857 (2018) (011) Genome-scale signatures of gene interaction from compound screens predict clinical efficacy of targeted cancer therapies. Peng Jiang, et al., Cell Systems, 6, 1-12 (2018) (012) eQTL: Maud Fagny, et al., PNAS, E7841-E7850 (2017) (013) pQTL: Jerome Carayol, et al., Nat Commun., 8: 2084 (2017)

The present invention has been devised to solve the above-described conventional problems, and the present invention has the genetic properties and fingerprints of functional genomes of the target genomes that respond to cancer drug reactivity according to the technical background and social needs as described above. To provide a high-accuracy drug indication and sensitivity prediction system by converting to a haplotype, a specific object of the present invention is known non-clinical cell line genomes, their gene expression information and gene duplication, and in vivo It is to provide a prediction system that can reliably predict the information-based linear regression modeling and deep learning machine learning with a collection of quantitative trait loci (QTL) related to drug response.

And in the present invention, the GBLscan method according to the present invention collects quantitative trait positions (QTL) that have high correlation with gene RNA expression and copy number variation (CNV) to generate multivariate-based haplotypes with functional information and drugs It is to provide a method for predicting drug reactivity for a virtual clinical trial (In Silico Clinical Trial) that effectively filters sensitivity and reactivity.

According to a feature of the present invention for achieving the object as described above, the present invention comprises the steps of: generating a collection of positions of quantitative trait locations (QTLs) to be examined; Calculating a functional response type (FRH) and a drug response correlation; And, it consists of the step of generating a functional haplotype-based drug response prediction model.

 First, in a first step for generating a location collection of quantitative features (QTLs); To perform a function-related haplotype (FRH) and drug-reactivity correlation calculation, (A) calculate about 4 million mutations and about 20,000 gene expression correlations in about 1,000 cell lines, and (B) drugs (265) ) And correlation between each 20,000 gene expression and gene replication variants of 1,000 cell line genomes.

At this time, steps (A) and (B) include both gene expression and gene copy number variations as common variables, and these common variables, gene expression information, are used to correlate with multiple or single mutations that affect drug responses. Collect the mutations you have. This is called a collection of quantitative trait locations (QTLs).

Then, a single and multiple mutation information is collected from each cell line genome in the genome-integrated DB to create functional haplotypes, extracted with drug reactivity information from the same cell line, and these functional haplotypes are functional haplotypes, FRH (Functionally relevant haplotope) ), And the FRH is expressed as a hash number.

  Then, in the second step, in order to calculate the correlation between the functional Haflow type (FRH) and the drug response, the Haflow type (FRH) is changed to a hash number, and the converted drug hash number is used to convert the drug reactivity information. The Pairwise Pearson Test is performed and the above operation is repeated for all carcinomas.

  In the third step of generating a functional hypoflow type-based drug response prediction model, a process related to generating a drug pathway-based drug response prediction model in a specific cancer is performed as follows.

(1) Calculate the correlation with each drug related to the function-related haplotype and specific cancer and drug pathway, and (2) X-axis and Y-axis in the functional haplotype and drug-reactivity correlation metrics. Cluster the correlation information, (3) collect the high significance (p-value) from each prediction model, apply the interaction function to the model to calculate the linear regression model, and finally (4) Using NGS data as inputs, we calculate the functional subflow type related to drug reactivity and predict the drug reactivity using a linear regression model.

And the present invention, to calculate the drug reactivity prediction model using the functional haflow type information as described above, using a number of variations in the base sequence collected from the genome to be tested to calculate the functional haflow type and : Calculating a solution of the linear regression model; A system for screening cancer drugs with high sensitivity among cancer drugs using such a solution is included.

On the other hand, explaining one of the various embodiments of the present invention, the present invention comprises the steps of: (A) calculating the positional collection of quantitative trait positions (QTLs) for variations affecting the drug response; (B) generating a functional subflow type for the variation included in the quantitative trait position (QTL); (C) calculating a correlation between a mutation and a drug response based on the functional subflow type; And (D) predicting drug responsiveness based on the functional subflow type.

In this case, calculating the positional collection of the quantitative trait positions (QTL) in the step (A) includes: (A1) deriving a correlation between mutations and gene RNA expression from a plurality of cell lines; (A2) deriving a correlation between drugs and gene RNA expression and gene copy number variation (CNV) contained in a plurality of cell line genomes; (A3) calculating gene expression information for gene RNA expression or gene duplication mutation, which commonly affects correlation in steps (A1) and (A2); And (A4) calculating a single or multiple mutations involved in the gene expression information to calculate a quantitative trait position (QTL) for mutations affecting the drug response. It can be performed, including the step of generating a collection of locations.

In addition, the generation of the functional subflow type in the step (B) may be generated by extracting the subflow type for a single or multiple mutations included in the quantitative trait position (QTL) from the genome integration DB together with the drug reactivity.

In addition, the functional underflow type includes correlation information between gene RNA expression (Exp) and drug responsiveness; It may also be configured to include information on the correlation between gene multiplex (loci) and drug responsiveness.

On the other hand, the functional subflow type, correlation information between the gene replication mutation (CNV) and drug response; It may also be configured to include information on the correlation between gene multiplex (loci) and drug responsiveness.

Here, the gene multivariate (loci) may be a collection of locus selected based on quantitative trait location (QTL).

In addition, the dielectric integration DB may be a Cell Lines integrated DB composed of a genotype.

In addition, the drug reactivity may be expressed by an ln Ic50 value.

In addition, the gene RNA expression may be divided into over-expression, normal, and under-exprfession.

In addition, the copy number variation (CNV) may be divided into amplification (amplification), no change (normal), and reduction (deletion).

On the other hand, the correlation calculation of the step (C) comprises: (C1) determining the gene RNA expression (Exp) associated with the gene multivariate (loci); (C2) calculating drug reactivity to the gene RNA expression (Exp) from the functional subtype to determine drug reactivity to the gene multivariate (loci); And (C3) comparing and verifying the drug responsiveness calculated from the correlation information between the gene multivariate (loci) included in the functional subflow type and the drug responsiveness and the drug responsiveness determined in step (C2). It may be carried out.

In addition, the association of the step (C1) may be performed by determining a cell line containing the gene multivariate (loci) and gene RNA expression (Exp) information included in the cell line.

In addition, predicting the drug reactivity of the step (D), when the difference in drug response to the difference in gene RNA expression is greater than the overexpression, it is determined that the low expression of gene RNA is sensitive to the drug reaction; When the difference in drug response to the difference in gene RNA expression is less than the overexpression, it may be determined that the overexpression of the gene RNA is sensitive to the drug reaction.

And predicting the drug reactivity of the step (D), the difference value of the absolute value of the absolute value of the drug response to the difference in gene RNA expression in the overexpression group is the highest value of the absolute value of the drug response sensitivity to the difference in the gene RNA expression of the low expression group. If it is greater than the difference value, it is determined that the overexpression of the gene RNA is associated with the gene multivariate (loci) type; If the difference value of the absolute value sensitivity of the drug response to the difference in gene RNA expression of the overexpression group is less than the difference value of the absolute value of the drug response absolute value of the difference of the gene RNA expression of the difference in gene RNA expression of the overexpression group, the low expression of gene RNA is gene multiplexed. It can also be determined to be associated with a loci type.

Meanwhile, the functional underflow type may be expressed as a hash number.

In addition, the correlation between the functional hypoflow type and the drug reaction may be calculated by performing a drug-reactivity information and a pairwise correlation test (Pairwise Pearson Test) using a hash number.

On the other hand, the present invention includes a drug-reaction type using a drug responsiveness, gene expression information, and copy number variation to generate a functional subtype in the same manner as described above.

At this time, the functional subflow type may be used for diagnosis of responsiveness to drugs, discovery of biomarkers for companion diagnosis to select patient groups for drugs, discovery of drug targets, or virtual clinical trials for drugs.

In the present invention regarding IGFR drug reactivity for a virtual clinical trial according to the present invention as described above, the following effects can be expected.

That is, in the present invention, since the sensitivity of each subject's genotype can be predicted for IGFR drugs through biomarkers for IGFR-type drugs, an effective preliminary verification is performed not only for personalized medicine fields but also for the discovery of new drug candidate groups. There is.

In addition, in the present invention, there is an effect of predicting the degree of reactivity of a drug whose pharmacological effect is unknown from the reactivity results of known drugs for in vivo, in vitro, or genetic information.

In addition, the present invention can derive the reactivity correlation of the pharmacological functional group constituting the drug to the variation information of the genome, and thus, if the variation of the genome to be analyzed and the pharmacological functional group of the drug are extracted, the degree of reactivity of the drug to the genome is determined. It has an effect that can be reliably predicted.

In addition, since the present invention can derive a drug type reactivity correlation with the genome variation characteristic information, knowing the characteristic information and the drug type information about the variation of the genome to be analyzed, the degree of reactivity of the drug to the genome can be reliably determined. It has a predictable effect.

Through this, the present invention can predict the reactivity to a cell line or a human body containing a specific genome of an unknown polymer compound (substance to be developed for drug) before a clinical trial, and thus can significantly reduce the time and cost of developing a new drug. In addition, even for drugs that have already been developed, the degree of reactivity to genomes other than those found in clinical trials can be predicted in advance, thereby significantly reducing the research cost and time for discovering other uses for drugs and finding side effects. There is.

Figure 1 is an exemplary diagram showing a quantitative trait location (QTL), genetic replication number variation and RNA expression examples for the drug response prediction according to the present invention.
Figure 2 is an exemplary view showing a drug response calculation scheme using a genetic biomarker according to the present invention.
Figure 3 is an exemplary view showing the relationship between the genetic biomarker of breast cancer and drug response according to the present invention.
Figure 4 is an exemplary diagram showing the NGS input and drug reaction and RNA expression network according to the present invention.
Figure 5 is an exemplary view showing the correlation of the cell line drug response value (IC50) and functional hypoflow type according to the present invention.
Figure 6 is an exemplary view showing a correlation between the quantitative trait location (QTL) and the drug response according to the present invention.
Figure 7 is an exemplary diagram showing a variation, RNA expression, gene replication number variation and drug response network according to the present invention.
8 is an exemplary diagram showing an example of cell line, cancer, drug response, RNA expression and CNV amplification correlated with mutation according to the present invention.
9 is an exemplary diagram showing a functional hypoflow type and a drug reactivity correlation calculation schema according to the present invention.
Figure 10 is an exemplary view showing a functional haplotype and drug-responsive network according to the present invention.
Figure 11 is an exemplary diagram showing an example of functional subflow type and gene expression and gene replication variation according to the present invention.
12 is an exemplary view showing a functional underflow type definition according to the present invention.
13 is an exemplary view showing an example of FRH method and gene expression and drug reactivity prediction according to the present invention.
14 is an exemplary view showing an example in which the difference in average IC50 values is 1.0 as an example of FRH according to the present invention.
15 is an exemplary view showing an example in which the difference in average IC50 values is 1.5 as an example of FRH according to the present invention.
16 is an exemplary view showing a functional subflow type and gene expression embodiment according to the present invention.
17 is an exemplary view showing a specific cancer drug pathway-based drug response prediction model generation example according to the present invention.
Figure 18 is an exemplary diagram showing the relationship between functional reactivity and drug reactivity R ^ 2 according to the present invention.
FIG. 19 is an exemplary view showing an embodiment of FRH having high FRH correlation with Afatinib drug in the example shown in FIG. 18.
20 is an exemplary view showing an embodiment of a prediction model using FRH having a high FRH correlation with Afatinib drug in the example shown in FIG. 18.
21 is an exemplary view showing an embodiment of predicting drug response of blood cancer using FRH according to the present invention.
22 is an exemplary view showing an example of an available system using FRH according to the present invention.
23 is an exemplary view showing an example of a method of manufacturing a cancer and drug companion diagnostic chip using the FRH biomarker according to the present invention.
24 is an exemplary view illustrating a configuration of a biomarker expression structure according to the present invention.
FIG. 25 is a graph showing correlation values (P-vlaue) values of major biomarkers for blood cancer drugs.
26 is a graph showing correlation values (P-vlaue) values for genes expressed by major biomarkers and blood cancer drugs.
27 is a graph showing the correlation (P-vlaue) values for female cancer drugs of major biomarkers.
28 is a graph showing correlation values (P-vlaue) values for genes expressed by major biomarkers and female cancer drugs.
Figure 29 is a graph showing the correlation (P-vlaue) values for brain tumor drugs of major biomarkers.
30 is a graph showing correlation values (P-vlaue) values for genes expressed by major biomarkers and brain tumor drugs.
Figure 31 is a graph showing the correlation (P-vlaue) values for the head and neck cancer drugs of the major biomarkers.
FIG. 32 is a graph showing correlation values (P-vlaue) values for genes expressed by major biomarkers and head and neck cancer drugs.
Figure 33 is a graph showing the correlation (P-vlaue) values for lung cancer drugs of major biomarkers.
FIG. 34 is a graph showing correlation values (P-vlaue) values for genes expressed by major biomarkers and lung cancer drugs.
35 is a graph showing correlation values (P-vlaue) of sarcoma cancer drugs of major biomarkers.
36 is a graph showing correlation values (P-vlaue) values for genes expressed by major biomarkers and sarcoma cancer drugs.
37 is a graph showing the correlation (P-vlaue) values of ABL drugs for major biomarkers.
38 is a graph showing the correlation (P-vlaue) values of CHROMATIN drugs for major biomarkers.
FIG. 39 is a graph showing correlation values (P-vlaue) of EGFR drugs for major biomarkers.
40 is a graph showing correlation (P-vlaue) values of ERK_MAPK drugs for major biomarkers.
41 is a graph showing the correlation (P-vlaue) values of IGFR drugs for major biomarkers.
Figure 42 is a graph showing the correlation (P-vlaue) values of MITOSIS drugs for major biomarkers.

Hereinafter, referring to the accompanying drawings, a functional haplo typing system and method using cancer drug responsiveness, linked gene expression information, and copy number variation for a virtual clinical trial according to a specific embodiment of the present invention will be described.

Prior to the description, first, the effects, features, and methods of achieving the present invention will be clarified in the embodiments described below in detail together with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but may be implemented in various different forms, and only the embodiments allow the disclosure of the present invention to be complete, and common knowledge in the technical field to which the present invention pertains. It is provided to fully inform the holder of the scope of the invention, and the invention is only defined by the scope of the claims.

In the description of the embodiments of the present invention, when it is determined that a detailed description of known functions or configurations may unnecessarily obscure the subject matter of the present invention, the detailed description will be omitted, and terms to be described later in the embodiments of the present invention These terms are defined in consideration of the functions of the user, and may vary depending on the user's or operator's intention or customs. Therefore, the definition should be made based on the contents throughout this specification.

1 is an exemplary diagram showing a quantitative trait location (QTL), genetic replication number variation, and RNA expression example for predicting a drug response according to the present invention, and FIG. 2 is a drug reactivity using the genetic biomarker according to the present invention. Figure 3 is an exemplary diagram showing the calculation schema, Figure 3 is an exemplary diagram showing the relationship between the genetic biomarker of breast cancer and drug response according to the present invention, Figure 4 is NGS input and drug response and RNA expression network according to the present invention 5 is an exemplary view showing a correlation between a cell line drug response value (IC50) and a functional hypoflow type according to the present invention, and FIG. 6 is a quantitative trait location (QTL) according to the present invention. An exemplary view showing a drug response correlation, FIG. 7 is an exemplary view showing a variation, RNA expression, gene replication number variation, and a drug response network according to the present invention, and FIG. 8 is a variation and correlation cell line according to the present invention , Cancer, drug reaction, RNA And CNV amplification example, FIG. 9 is an exemplary diagram showing a functional hypoflow type and drug reactivity correlation calculation schema according to the present invention, and FIG. 10 is a functional hypoflow type and drug reactivity network according to the present invention 11 is an exemplary view showing an example of a functional underflow type and gene expression and gene replication modification according to the present invention, and FIG. 12 is an example showing a functional underflow type definition according to the present invention. FIG. 13 is an exemplary view showing an example of FRH method and gene expression and drug reactivity prediction according to the present invention, and FIG. 14 is an example of the FRH according to the present invention, wherein the average IC50 value is 1.0. 15 is an exemplary view showing an example in which the difference in average IC50 value is 1.5 as an example of FRH according to the present invention, and FIG. 16 is a functional underflow type and gene expression according to the present invention. Example showing an example It is an attempt, and FIG. 17 is an exemplary view showing a specific cancer drug pathway-based drug response prediction model generation example according to the present invention, and FIG. 18 is a functional hypoflow type according to the present invention and a drug reactivity relationship R ^ 2 is an exemplary view showing FIG. 19 is an exemplary view showing an embodiment of FRH having a high FRH correlation with Afatinib drug in the example shown in FIG. 18, and FIG. 20 is Afatinib in the example shown in FIG. It is an exemplary view showing an embodiment of a prediction model using FRH having a high correlation with drugs and FRH, and FIG. 21 is an exemplary view showing an embodiment of predicting drug response of blood cancer using FRH according to the present invention, 22 is an exemplary view showing an example of an available system using FRH according to the present invention, and FIG. 23 is an example of a method of manufacturing a cancer and drug companion diagnostic chip using the FRH biomarker according to the present invention Illustrative diagram shown, Figure 24 is the present foot For an illustration for explaining an arrangement of a biomarker expressed by a structure diagram.

The present invention is basically, (A) quantitative RNA location information (QTL) of gene RNA expression information and replication variation information that is difficult to clinically extract from cancer patients, (B) non-clinical cell line DB (GDSC and CCLE) ), Using the common data, such as gene RNA expression information and copy number mutation information and drug-reactivity correlation experiment information, and then integrating the steps (A) and (B) to quantitative quantitative position (QTL) And the cancer drug response correlation is calculated to generate a predictive model.

Then, based on genomic information that can be obtained from cancer patients, the haplotype including functional information is calculated to predict drug response information of cancer patients.

Figure 1 shows an example of quantitative trait location (QTL), genetic replication variability and RNA expression for predicting drug response. That is, in the eQTL experimental example of ①, it is shown that it is regulated by direct (cis) and indirect (trans) methods of mutation and expression, and ② Drug-Gene Expression of ② shows the correlation between drug and RNA expression. And Drug Cell viabillity in ③ shows the relationship between drug concentration and cell activity, and Drug-CNV in ④ shows the correlation between drug concentration and gene copy number variation (CNV). And Expression-CNV in ⑤ shows the correlation between gene expression and copy number variation (CNV).

That is, Figure 1 shows that the concentration of the drug and RNA expression and gene replication variation (CNV) correlate with each other, and in many cases, RNA expression and gene replication variation (CNV) are the cause of it. Shows correlation with single and multiple mutations.

In FIG. 2, in the schema for calculating the drug reactivity using a genetic biomarker, most known active drugs are divided into a drug-sensitive group and a drug-resistant group, wherein the sensitivity and resistance are closely related to the genetic biomarker. Connected.

Here, the genetic biomarker is composed of reproductive and somatic mutations, driver mutations, replication mutations, functional haplotype mutations, epigenetic mutations methylation and gene expression.

And, Figure 3 shows an example of the relationship between the genetic biomarker of breast cancer and drug responsiveness. A) Schematic diagram showing the mechanism of genetic biomarkers, when the Her2 gene is overexpressed, tratuzumab, a drug targeting the cell surface receptor, lapatinib targeting the antagonist in the cytoplasm inside the cell, and two biomarkers PI3CA And PTEN locations. B) The graph shows the calculated results of drug reactivity in the case of tratuzumab and lapatinib in the case where the wild type and PI3CA have mutations and does not function up to PTEN, and the biomarker according to the position of the drug target in the drug pathway mechanism. It is shown that the variation of the drug reactivity for 1 and 2 is different.

Meanwhile, FIG. 4 shows an example of NGS input, drug reaction, and RNA expression network.

The basic structure of NGS input, drug response, and RNA expression network is: A) Predicted amplification / decrease of gene RNA overexpression / low expression and gene copy number variation based on quantitative trait location (QTL) calculated from NGS input data, B) Using non-clinical common drug reactivity data, gene expression data, and correlation information, C) Predict the quantitative trait location (QTL) -based drug response in clinical practice.

The present invention can be described as a process of obtaining A) quantitative trait location (QTL) information, B) gene RNA expression information and drug reactivity test data library (DB), and C) predicting drug reactivity. This is because, in general, it is difficult to obtain the drug response information and gene expression information of step B) in a short time for the patient, or partly impossible.

Accordingly, FIGS. 1 to 4 secure single and multiple mutation information related to quantitative trait location (QTL) information based on genomic information and RNA expression information from a patient, and are non-clinical (in vitro) cell lines that are common drug reactivity information. It is a method of making connection with experimental information and applying it to patients in clinical practice.

5 is an example of the correlation between the cell line drug response value (IC50) and the functional hypoflow type, and FIG. 5 shows an example of finally calculating the correlation between the cell lines and the drug reactivity information and the functional hypoflow type with the Pearson correlation. have. In FIG. 5, 265 drugs are classified into 18 (Dn) drug pathways and applied, and the functional subtype is already based on quantitative trait location (QTL) information in each cell line genome for 12 carcinomas (Cancer N). It shows a schematic diagram of finding the Pearson correlation by replacing the combinations (multivariations) of mutations related to the response with a hash number.

And Figure 6 shows an exemplary diagram of the correlation between the quantitative trait location (QTL) and the drug response. ① is eQTL, ② is cQTL, ③ is dQTL, ④ is the correlation between gene RNA expression and gene replication number variation, ⑤ is the correlation between drug concentration and gene RNA expression, and ⑥ is the correlation between drug concentration and gene replication number variation.

In the present invention, ① eQTL and ② cQTL are used, and ③ to ⑥ show a state as a result or correlation.

FIG. 7 is an exemplary diagram showing a network structure of mutation, RNA expression, gene replication number variation, and drug response, and is a schematic diagram in which networking of the content shown in FIG. 6 is made with respect to each other, and genotype (single mutation), ha It shows the relationship between flow type (combination and multivariate) and conditional expressions of drug reactions.

In the present invention, the functional subflow type collectively refers to both single and multiple variants.

In addition, each variation is collected by determining the correlation between gene RNA expression and gene replication number variation by a method of quantitative trait location (QTL) with a p-value <10 ^ 5 or less.

On the other hand, Figure 8 shows an example of cell line, cancer, drug response, RNA expression and CNV amplification correlated with mutation. At this time, examples of mutually related mutations and cell lines, cancer, drug reactions, RNA expression, and CNV amplification are finally selected quantitative trait location (QTL) -based drug responsiveness-mutation-RNA expression-CNV as one object.

In addition, the variation (genotype) may be linked to the location of the chromosome, the variation type, the amino acid variation, information on whether or not the biomarker is used.

On the other hand, according to the functional hypoflow type and the drug reaction correlation calculation schema shown in FIG. 9, the present invention is largely composed of the first step and the second step.

The first step is a step of generating a location collection of quantitative trait positions (QTLs), and the second step is a step of calculating the correlation between the functional hypoflow type and the drug response.

Specifically, the first step is 1) calculating the expression correlation between mutations (4 million in total) and genes (20,000), and 2) gene expression of drugs (265) and cell line genome (1,000) ( Calculating the correlation of each 20,000), 3) collecting the same gene expression pattern associated with multiple or single mutations in 1) and 2), and 4) haplotype (single and Multivariate) is carried out including the step of extracting with drug reactivity.

And the second step is 5) defining such a Haflow type as a function Haflow type (FRH), which is a function and related Haflow type, and expressing the FRH as a hash number and 6) a hash number. Comprising the step of calculating the drug responsive combination correlation test (Pairwise Pearson Test), these processes are repeated in all cancer species.

In addition, FIG. 10 shows a network of functional haplotypes and drug responsiveness, and shows a system for implementing the functional haplotyping method illustrated in FIG. 9.

That is, the process of extracting the functional subflow type by extracting multiple mutations from the Cell Lines (c1 to cN) integrated DB composed of Genotype and the relationship between single or multiple mutations by QTL method and gene RNA expression and drug response data is shown. have.

In addition, in the functional lower flow type and gene RNA expression and gene replication mutant of FIG. 11, the process of FIG. 9 will be described in detail from a functional point of view.

In other words, A) expresses the relationship between drug reactivity information and gene RNA expression as the final result of multiple facets (loci) and Exp, and the relationship between drug reactivity information and gene replication variable (CNV) is expressed as loci and CNV. Is showing.

And B) is a detailed schema for this, in the case of Ln Ic50 for drugs, '-2' represents sensitivity, '0' represents intermediate sensitivity, and '2' represents drug resistance.

On the other hand, multivariate (loci) is described as a collection of locus selected based on quantitative trait location (QTL), and loci is expressed by various types of loci-1, loci-2, ... loci-N, and each The loci type has a frequency in the whole group.

Then, in each frequency group, ln IC50 values (X, Y, ... Z), which are average drug reactivity information, are calculated.

On the other hand, in the case of gene RNA expression, there are three different expression patterns, which can be expressed in over-expression, normal, and under-exprfession formats, and the loci type and In the same way, frequency can be grouped in each type, and average Ln IC50 values (X ', Y', ... Z ') in each group are calculated.

And in the same way, in the case of CNV, which is a replication variable, it is divided into amplification, no change, and deletion, and ln IC50 value, which is the average drug reactivity information in each frequency group. X ", Y", ... Z ") are calculated.

In addition, all the loci, gene-exp, and gene-CNV values can be expressed on a scale of 0 to 1 in the form of weights.

Therefore, B) can be described as multiplying the weight by loci and Exp, loci and CNV.

FIG. 12 shows a functional haplotype definition, and in the present invention, a relative functional haplotype refers to a functional haplotype (FRH) and a combination of locus giving significance in eQTL (Loci). It refers to the relationship of the associated Haflow type.

Here, the functional subflow type is the genomic assembly version Dec. 2013 (GRCh38 / hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 Based on the reference sequence, individual cell lines and individuals It is defined as a form with different polymorphism information (allele). And FRH (Exp | IC50) represents the absolute difference in sensitivity of the drug response to the gene expression difference (Normal vs. Over or Under), and FRH (Loci | IC50) is a drug corresponding to the functionally related haplotype for cell lines. This is the difference in the absolute sensitivity of the response.

Therefore, the relationship between the drug response value and the gene RNA expression and the gene RNA expression of the same pattern as the specific type of loci can be linked. For example, in FIG. 12, loci-3 and [1] Exp of [2] It shows that it is connected to -over.

That is, loci-3 has a QTL relationship with RNA expression being over, and when RNA expression is over, the drug reactivity value can be predicted to be the same as the loci-3 drug expression value.

In addition, as shown in [3], FRH (Exp | IC50) shows a large value (max) with a difference in absolute drug response compared to the drug reactivity value at no change, and FRH (Loci | IC50). ) Represents the largest value (max) of the difference in absolute drug response compared to the drug response value at no change (normal) in various haplotypes.

On the other hand, in FIG. 13, through the example of predicting the FRH method and gene expression and drug reactivity, the Haflow type defined in FIG. 12 can be described in more detail.

That is, [1] and [2] of FIG. 13 represent the absolute difference in sensitivity (max or over or under) of the drug response to the gene expression difference, respectively, and [3] is a functionally related haplotype for cell lines. Represents the absolute value sensitivity max difference corresponding to the drug response, and [4] indicates that the difference in the drug response to the expression difference is greater than the low expression, s = 1, and vice versa. Therefore, s = 1 means that overexpression is sensitive to drug response, and S = 0 means that low expression is sensitive to drug response.

And [5] indicates that m = 1 if ds ^ over defined in [1] and [2] is greater than ds ^ under, otherwise m = 0, and if m = 1, a specific loci type is overexpressed in the case of a gene , And when m = 0, it means that the low expression of the gene is associated with a specific loci type.

On the other hand, Figure 14 shows an example of the difference in the average IC50 value '1.0' as an example of the FRH in a table. Here, when the average drug reactivity (LN IC50) is 1, it shows a high positive correlation (pval <2.812 * 10 ^ -7).

In addition, FIG. 15 shows an example data in which the difference of the average IC50 value is '1.5' as an example of FRH in a table. Here, when the average drug reactivity (LN IC50) is 1.5, it shows a much higher negative correlation (pval <7.191 * 10 ^ -7).

In addition, FIG. 16 shows an example of functionally related haplotype and gene expression.

In the case of this example, in the case of blood cancer, it is shown that FRH includes four types. At this time, the variation (locus position) is described as three different genotypes: 1: Ref Homo, 2: Hetero, and 3: Alt Homo.

And when expressed as a combination of two locus in the blood of the first column, the frequency of each type is the second column, one in '12', one in '21', and one in '11'. 2 and '22' show a majority with 153.

In addition, in the case of '11' for Afatinib drugs, gene expression is overexpression (2.404), and drug reactivity (LN IC50) is -1.21, that is, it is sensitive to Afatinib drugs. Summarizing the contents of this example, FRH with two locus combinations overexpresses the EGFR gene in the '11' type, which is responsible for the drug reactivity. Therefore, it can be predicted that FRH is a cell line with '11' type and patients are sensitive to Afatinib drug.

And FIG. 17 illustrates a method for generating a drug response prediction model based on a specific cancer drug pathway. As shown in the figure, a model for predicting a drug response based on a specific cancer drug pathway is 1) a correlation between a function-related haplotype (FRH) and each drug related to a specific drug drug pathway of a specific cancer. Calculates, 2) clusters the correlation information of the metric X-axis and Y-axis consisting of the FRH and drug-reactivity correlations, and 3) collects those with high p-value in the predictive model, and interacts with them. The function is applied to the model, and 4) the drug reactivity is predicted by calculating the FRH related to the drug reactivity with NGS data as input.

On the other hand, the functional flow type shown in FIG. 18 and the drug reactivity relationship R ^ 2 describe an example of the clustering process of 2) correlation information of the method for generating the predictive model of FIG. 17. Here, the cancer type is blood cancer, Y: EGFR pathway 9 drugs, X: FRH haplotype, and each pixel represents the Pearson correlation between the drug response value and FRH, where * indicates significance (pval <0.05), ** indicates significance (pval <0.01).

In addition, blue color shows a positive correlation, and orange color shows a negative correlation.

And FIG. 19 shows an example of FRH having high FRH correlation with Afatinib drug in the example of FIG. 18. In particular, the results show the correlation between the four FRHs (LAMC2_2, JPH1_2, PRKCB_3, CML_1) and drug response.

Meanwhile, FIG. 20 is an example of a prediction model using FRH having a high FRH correlation with Afatinib drug in the example of FIG. 18, and an example of applying 3) interaction function of the prediction model generation method of FIG. 17 to a model will be described. . In particular, 21 FRHs with p-val <0.01 or less are put into an interaction term and an example of applying a linear regression model. In this case, the Pearson correlation is 0.89.

In addition, FIG. 21 shows predicted IC50 (real) values for various drugs (AP-24534, PAC-1, Obatoclax Mesylate, Bleomycin, etc.) with the functional subtype of the genome of one patient with blood cancer. As a result, some drugs were predicted to be highly sensitive, while others were predicted to be highly resistant. And there is a correspondence between the sensitivity of the actual value (IC50 (real)) and the average IC50 (ave) value of the functional Haflow type group.

On the other hand, as shown in Figure 22, the next-generation sequencing data based on the functional haplotypes according to the present invention can be utilized in various areas. That is, it can be used in virtual clinical trials and actual clinical trials, discovery of new drug targets, diagnosis of disease drug susceptibility, and discovery of biomarkers for companion diagnostics.

In the present invention, significant biomarkers were found in diagnosing drug responsiveness through the functional hypoflow type as described above.

The excavated biomarkers are DNA bases containing mutations, which are largely classified according to the type of cancer (CancerClass) and the biomarkers that affect the drug's reactivity to the cancer and the drug's pathway and expression target. It is divided into biomarkers that affect drug reactivity by drug class (DrugClass).

Hereinafter, such biomarkers will be classified and sorted.

First, the classification types for the cancer type (CancerClass) are summarized in [Table 1].

Definition of the cancer genome atlas (TCGA) belonging to CancerClass division CancerClass TCGA CANCER_NAME One Blood cancer ALL
LAML
LCML Acute lymphoblastic leukemia, Acute Myeloid Leukemia, Chronic Myelogenous Leukemia 2 Female cancer (breast, ovary) BRCA
BLCA
UCEC
OV
CESC Bladder Urothelial Carcinoma, Breast invasive carcinoma, Ovarian serous cystadenocarcinoma,
Cervical squamous cell carcinoma and endocervical adenocarcinoma, Uterine Corpus Endometrial Carcinoma 3 Brain tumor LGG
NB
GBM Glioblastoma multiforme, Brain Lower Grade Glioma, Neuroblastoma (nb) 4 Head and neck cancer HNSC
THCA Head and Neck squamous cell carcinoma, Thyroid carcinoma 5 Lung cancer LUAD
LUSC
NSCLC Lung adenocarcinoma, Lung squamous cell carcinoma 6 Sarcoma cancer SARC Sarcoma

The cancer classes listed in [Table 1] above are classified by cancer occurrence sites and causes, including blood cancer, female cancer, brain tumor, brain and head and neck, lung cancer, and sarcoma. It is divided into bones.

And TCGA indicates the detailed cancer types classified in 'The cancer genome atlas', and information on each item is listed in [Table 1].

As described above, in the present invention, the biomarkers that affect the reactivity to drugs for each cancer type were calculated through GBLscan using the functional Haflow type.

Specifically, 225 biomarkers of blood cancer (see Table 2), 50 biomarkers of breast and ovary (see Table 4), brain tumors, by type of cancer class 894 biomarkers (see Table 6), 32 head and neck biomarkers (see Table 8), 277 lung lung biomarkers (see Table 10), biomarkers of sarcoma cancer (bone) 331 (see Table 12).

[Table 2] to [Table 12] below show biomarkers discovered by the present invention for each cancer type. Here, the biomarker may be a combination of a single mutation and a multiple mutation, and the forms of the mutations may also be of various forms such as a single nucleotide polymorphism (SNV), an indel, gene copy number variation (CNV), and a chromosomal rearrangement. It can be a mutation.

On the other hand, Gene_EXP displayed in the present invention, as shown in Figure 24, indicates the name of the mRNA expression gene of the biomarker. In addition, the biomarker is expressed in the form of "Marker 1_Marker 2_Marker3_Marker4", and Marker1 indicates a chromosome number containing a mutation and has a value of 1 to 22 or X, Y. . In addition, the marker 2 indicates the starting position of the nucleotide sequence in which the mutation occurred on the chromosome, and the marker 3 indicates the normal base before the mutation and refers to the base of the corresponding position on the reference genome (based on GRCh / hg38). On the other hand, Table 4 shows the mutated base.

That is, the variations expressed in the form of "Mark 1_Mark 2_Mark 3_Mark 4" shown in [Table 2] to [Table 12] and [Table 15] to [Table 27] are in the marker 1 chromosome, Refers to the base sequence in which Mark 3 base from Mark 2 is changed to Mark 4.

Thus, at this time, the biomarker specifically refers to a base sequence consisting of the base of the marker 4, the position from the second position of the marker to the base length of the marker 3 in the marker 1 chromosome.

For example, the biomarker of SEQ ID NO: 1 in [Table 2] was expressed as “14_30910985_T_G”, which means that the base sequence of the 30910985 th base of chromosome 14 is the biomarker, and the sequence of SEQ ID NO: 5 of [Table 2] The biomarker was expressed as `` 13_113524119_TGTCA_T, 13_113510211_T_C, 13_113495576_T_C, 13_113503637_G_T, 13_113539563_C_T '', which means that the bases from the 113524119 bases of chromosome 13 to 113524123 are T (the base of 4 digits is 'deleted', 13 bases) This means that the nucleotide sequence of chromosome 113510211 is C, the 113495576 base of chromosome 13 is C, the 113503637 base of chromosome 13 is T, and the chromosome 113539563 of chromosome 13 is a biomarker.

Looking at the example shown in FIG. 24, in the biomarker described in SEQ ID NO: 29 of [Table 23], in the 'SLC6A12' chromosome, the 190673067th base of chromosome 2 is GT, and the 114323991th base of ninth chromosome is G. it means. At this time, the 190673067th base of chromosome 2 refers to G being substituted with GT.

Meanwhile, as described above, the entire nucleotide sequence of chromosomes 1 to 22 is a genomic assembly version of Dec. 2013 (GRCh38 / hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 Refers to the reference sequence.

Table 2 lists the FRHs associated with blood cancer drugs and the markers defining the blood cancer drugs and FRHs associated with them.

In addition, [Table 3] summarizes the results of calculating the degree of reactivity (P-value) of FRHs shown in [Table 2].

In these tables, FRH was expressed in the form of "FRH name_number of included markers", and "Var_Exp (pval)" means the correlation (Pvlaue) value of each marker on the corresponding gene expression, and "Var_Drug (pval)" Means the correlation (P-vlaue) value of the corresponding marker on the reactivity of the drug, and according to the order of drugs listed in [Table 2], the reactivity correlation value for each drug is divided into the classification factor 『/』 『Exp_Drug (pval)』, the correlation value (Pvlaue) of the gene reactivity with the corresponding gene expression is arranged according to the order of drugs listed in [Table 2], and 『Ave_VarDrug (pval)』 is 『 Var_Drug (pval) ”means the average value of the calculated values, and“ Rank ”means the number of blood cancer drugs that the corresponding FRH significantly affects.

From these reactivity verification results, the lower the Var_Exp (pval), the lower the Var_Drug (pval) and its average value, Ave_VarDrug (pval), the lower the Exp_Drug (pval), the higher the Rank number, the corresponding marker determines drug reactivity It can be judged that the effectiveness is high as a biomarker.

On the other hand, in FIG. 25, correlation values (P-vlaue) values of blood biologic drugs of major biomarkers among the biomarkers listed in Table 2 are graphically displayed, and FIG. 26 shows genes expressed by the major biomarkers. The correlation values (P-vlaue) values for the fields and blood cancer drugs are plotted.

Reactive biomarkers for blood cancer drugs No. FRH Drug DrugType Var (marker) One MYB_5 1017_Olaparib / 1054_PD-0332991 / 1175_AG-014699 / 1006_Cytarabine / 1013_Nilotinib / 1495_Olaparib / 1010_Gefitinib / 1050_ZM-447439 / 1019_Bosutinib / 1011_ABT-263 / 1021_Axitinib / 1018_Brazil / 1018_62 2206 / 1032_Afatinib / 1015_CI-1040 / 1020_Lenalidomide / 1066_AZD6482 / 308_XL-880 / 1033_Vismodegib / 1014_RDEA119 / 1049_PD-173074 / 1038_NU-7441 g_integrity / cell_cyc / g_integrity / DNArep / abl / g_integrity / egfr / mitosis / abl / apop / rtk / g_integrity / other / cell_cyc / erk_mapk / rtk / pi3k / egfr / erk_mapk / other / pi3k / rtk / other / erk_mapk / rtk g_integrity 13_37746458_AA_A / 16_46710765_T_A / 11_63382198_CA_C / 14_68477626_CT_C / 7_151221500_CT_C 2 CCND3_2 1006_Cytarabine_1 / 226_GSK1070916_2 / 32_Tozasertib_2 / 1054_Palbociclib_2 / 231_FMK_3 / 1050_ZM447439_3 / 167_OSU-03012_3 / 59_WZ-1-84_3 / 197_Bryostatin_1_2 / 1495_Olaparib_1 / 395 DNArep / mitosis / mitosis / cell_cyc / erk_mapk / mitosis / pi3k / other / other / g_integrity / other / egfr / other 14_68477626_CT_C / 7_151221500_CT_C 3 CLEC11A_2 1014_Refametinib_2 / 1526_Refametinib_3 / 1060_PD0325901_2 / 263_FR-180204_3 / 1242_ (5Z) -7-Oxozeaenol_3 / 1015_CI-1040_2 / 224_AS605240_3 / 1498_Selumetinib_2 / 254_Quizartinib_2 / 29AZ erk_mapk / erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / pi3k / erk_mapk / rtk / erk_mapk 16_46710765_T_A / 5_179863845_T_G 4 SLFN11_1 1494_SN-38_3 / 1259_Talazoparib_3 / 136_Mitomycin-C_1 / 1003_Camptothecin_1 / 1006_Cytarabine_1 / 226_GSK1070916_2 / 134_Etoposide_1 / 1005_Cisplatin_1 / 135_Gemcitabine_1 DNArep / g_integrity / DNArep / DNArep / DNArep / mitosis / DNArep / DNArep / DNArep 1_215675245_T_C 5 GLUL_1 1013_Nilotinib_1 / 1021_Axitinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 / 34_Imatinib_1 / 52_GNF-2_3 / 1050_ZM447439_3 abl / rtk / erk_mapk / erk_mapk / abl / abl / mitosis 16_46710765_T_A 6 ARRB1_1 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 29_AZ628_3 / 263_FR-180204_3 / 1242_ (5Z) -7-Oxozeaenol_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / other 16_46710765_T_A 7 UBASH3B_1 1006_Cytarabine_1 / 226_GSK1070916_2 / 1050_ZM447439_3 / 211_TL-2-105_3 / 1054_Palbociclib_2 / 279_BIX02189_3 / 282_Pelitinib_2 DNArep / mitosis / mitosis / erk_mapk / cell_cyc / other / egfr 14_68477626_CT_C 8 TNFRSF1A_2 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1015_CI-1040_2 / 1372_Trametinib_1 / 29_AZ628_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 16_46710765_T_A / 6_71969190_A_G 9 FLT3_1 277_Linifanib_2 / 249_Cabozantinib_1 / 254_Quizartinib_2 / 308_WIKI4_2 / 226_GSK1070916_2 / 222_BX-912_3 / 153_Midostaurin_2 rtk / rtk / rtk / rtk / mitosis / pi3k / rtk 2_110841381_C_T 10 TAF3_1 1060_PD0325901_2 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 1015_CI-1040_2 / 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 1_75148689_A_T 11 RNF169_1 1013_Nilotinib_1 / 1021_Axitinib_2 / 261_TL-1-85_3 / 260_NG-25_3 / 211_TL-2-105_3 / 295_NVP-BHG712_3 abl / rtk / other / other / erk_mapk / rtk 6_119180436_T_TAA 12 AGTRAP_1 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 / 1015_CI-1040_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 2_178769706_G_T 13 DDX60L_1 1014_Refametinib_2 / 1498_Selumetinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 224_AS605240_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / pi3k 6_143772215_C_T 14 MARCH9_1 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1526_Refametinib_3 / 1015_CI-1040_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 14_30910985_T_G 15 OSBPL5_1 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1242_ (5Z) -7-Oxozeaenol_3 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk / erk_mapk / other / erk_mapk 2_232380431_T_C 16 ZNF22_1 300_CX-5461_3 / 272_AR-42_2 / 226_GSK1070916_2 / 274_Belinostat_1 / 257_NPK76-II-72-1_3 / 276_CAY10603_3 other / chromatin / mitosis / chromatin / mitosis / chromatin 2_97507111_G_A 17 DGAT1_3 1014_Refametinib_2 / 1526_Refametinib_3 / 1021_Axitinib_2 / 1013_Nilotinib_1 / 1060_PD0325901_2 / 1011_Navitoclax_2 erk_mapk / erk_mapk / rtk / abl / erk_mapk / apop 3_38910262_T_C / 11_18484005_G_A / 3_38905381_A_T 18 ORMDL3_2 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 19_49044101_A_G / 2_178769706_G_T 19 ROPN1L_2 1014_Refametinib_2 / 1060_PD0325901_2 / 1498_Selumetinib_2 / 1526_Refametinib_3 / 1015_CI-1040_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 16_33978977_C_T / 2_200876848_T_C 20 MSI2_1 1498_Selumetinib_2 / 1526_Refametinib_3 / 1060_PD0325901_2 / 1014_Refametinib_2 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 22_43972861_C_T 21 PSTPIP2_2 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1015_CI-1040_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 6_143772215_C_T / 6_143760631_C_A 22 MYL6B_1 1498_Selumetinib_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 11_284257_G_A 23 LPAR6_2 1011_Navitoclax_2 / 1054_Palbociclib_2 / 1021_Axitinib_2 / 1050_ZM447439_3 / 226_GSK1070916_2 apop / cell_cyc / rtk / mitosis / mitosis X_136033510_GA_G / 12_131908770_A_C 24 RIPK2_5 231_FMK_3 / 226_GSK1070916_2 / 225_Genentech Cpd 10_3 / 203_BMS-345541_3 / 205_Avagacestat_2 erk_mapk / mitosis / mitosis / other / other 6_152444591_GA_G / 19_13993876_CT_C / 13_37746457_TAA_TA / 5_64507681_TA_T / 10_67956845_TA_T 25 KIF15_1 1006_Cytarabine_1 / 1054_Palbociclib_2 / 1050_ZM447439_3 / 226_GSK1070916_2 DNArep / cell_cyc / mitosis / mitosis 15_100152748_G_A 26 ATP11A_2 1498_Selumetinib_2 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 2_85880864_T_C / 3_132388903_G_A 27 ZYX_1_9 1014_Refametinib_2 / 1060_PD0325901_2 / 1498_Selumetinib_2 / 1526_Refametinib_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk 11_129905704_C_T 28 SNRPG_5_5 1498_Selumetinib_2 / 1060_PD0325901_2 / 1014_Refametinib_2 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk / erk_mapk 7_12369637_C_A / 7_12369701_C_T / 7_12369909_A_G / 7_12361157_C_T / 7_12361395_C_T 29 RABGAP1_4_4 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1015_CI-1040_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 3_10260372_A_G / 17_20204460_T_C / 17_20357788_A_G / 17_20205876_C_T 30 AEBP1_5_4 1006_Cytarabine_1 / 167_OSU-03012_3 / 182_Obatoclax Mesylate_2 / 226_GSK1070916_2 DNArep / pi3k / apop / mitosis 16_13922252_CT_C / 13_37746457_TAA_TA / 1_108982799_TA_T / 6_152444591_GA_G / 17_64858885_TA_T 31 HNRNPA0_5_7 226_GSK1070916_2 / 300_CX-5461_3 / 134_Etoposide_1 / 225_Genentech Cpd 10_3 mitosis / other / DNArep / mitosis 11_63382198_CA_C / 15_42211755_GA_G / 15_55680462_CT_C / 20_34750522_TA_T / 11_33353067_AT_A 32 PVRL2_1_15 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 / 34_Imatinib_1 erk_mapk / erk_mapk / erk_mapk / abl 17_999610_T_C 33 KIAA1377_1_4 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 19_2896950_T_C 34 THEM4_5_4 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 / 300_CX-5461_3 / 175_PAC-1_2 mitosis / pi3k / other / apop 13_37746457_TAA_TA / 7_151221500_CT_C / 1_108982799_TA_T / 2_53919250_GA_G / 15_42211755_GA_G 35 RBM15B_4_4 1054_Palbociclib_2 / 1050_ZM447439_3 / 226_GSK1070916_2 / 1006_Cytarabine_1 cell_cyc / mitosis / mitosis / DNArep 11_63382198_CA_C / 5_75576972_GA_G / 8_73582883_GA_G / 10_67956845_TA_T 36 C10orf11_1_7 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 1_13344015_T_C 37 NSMAF_1_7 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 29_AZ628_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk 1_117088769_T_C 38 FRAT2_2_9 1526_Refametinib_3 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 1_215813880_T_C / 1_215838019_T_C 39 LRPAP1_2_3 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk 7_36335190_G_A / 22_39052745_T_C 40 PRAM1_3_3 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk 7_128805316_G_A / 2_178769706_G_T / 2_232380380_A_G 41 RAG1_2_3 182_Obatoclax Mesylate_2 / 175_PAC-1_2 / 1006_Cytarabine_1 apop / apop / DNArep 19_11301321_TA_T / 4_105719027_C_A 42 CARHSP1_2_3 1006_Cytarabine_1 / 226_GSK1070916_2 / 1054_Palbociclib_2 DNArep / mitosis / cell_cyc 14_68477626_CT_C / 13_24781827_GTT_GT 43 MBLAC1_1_3 1498_Selumetinib_2 / 1014_Refametinib_2 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk 3_179365291_C_T 44 RAG2_3_4 1006_Cytarabine_1 / 175_PAC-1_2 / 300_CX-5461_3 DNArep / apop / other 3_112112876_TA_T / 12_21806064_CA_C / 19_11301321_TA_T 45 HNMT_1_4 1526_Refametinib_3 / 1498_Selumetinib_2 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk 1_1756186_T_C 46 KCTD7_2_5 1498_Selumetinib_2 / 1014_Refametinib_2 / 1526_Refametinib_3 erk_mapk / erk_mapk / erk_mapk 11_63719914_T_C / 11_63646490_AAAAT_A 47 GSN_1_6 1498_Selumetinib_2 / 1372_Trametinib_1 / 1060_PD0325901_2 erk_mapk / erk_mapk / erk_mapk 11_129905704_C_T 48 CBFB_2_5 1006_Cytarabine_1 / 182_Obatoclax Mesylate_2 / 1004_Vinblastine_1 DNArep / apop / cytoskeleton 15_74183919_A_G / 3_112112876_TA_T 49 FBXO33_1_4 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 erk_mapk / erk_mapk / erk_mapk 8_143538013_T_C 50 ZBED4_2_4 1054_Palbociclib_2 / 257_NPK76-II-72-1_3 / 1011_Navitoclax_2 cell_cyc / mitosis / apop 7_100590017_T_G / 22_23698377_AT_A 51 COPS8_5_6 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 erk_mapk / erk_mapk / erk_mapk 11_69072603_C_T / 11_124023539_A_G / 16_57082546_T_C / 6_31878964_C_A / 7_100220478_G_A 52 ISG20_1_12 1014_Refametinib_2 / 1060_PD0325901_2 / 263_FR-180204_3 erk_mapk / erk_mapk / erk_mapk 5_179863845_T_G 53 LGALS12_3_4 1526_Refametinib_3 / 1060_PD0325901_2 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk 14_63384641_T_C / 7_128804766_A_G / 7_128805316_G_A 54 SNRNP48_5_3 1006_Cytarabine_1 / 1050_ZM447439_3 / 1054_Palbociclib_2 DNArep / mitosis / cell_cyc 16_57460490_GA_G / 16_30280420_GA_G / 8_108228149_GA_G / 1_179120104_GA_G / 9_67192757_GA_G 55 VPS37C_3_4 182_Obatoclax Mesylate_2 / 175_PAC-1_2 / 205_Avagacestat_2 apop / apop / other 5_146267624_CT_C / 3_160416453_CT_C / 12_15623289_TA_T 56 ATP6V0A1_1_3 1494_SN-38_3 / 226_GSK1070916_2 / 1006_Cytarabine_1 DNArep / mitosis / DNArep 11_63382198_CA_C 57 HEATR5A_5_6 205_Avagacestat_2 / 226_GSK1070916_2 / 192_LFM-A13_3 other / mitosis / other 7_151221500_CT_C / 9_120989554_CT_C / 4_106236542_TA_T / 7_77937691_AT_A / 15_42211755_GA_G 58 ENG_2_8 249_Cabozantinib_1 / 308_WIKI4_2 / 263_FR-180204_3 rtk / rtk / erk_mapk 3_186558604_C_T / 22_29806785_G_C 59 USF1_5_7 228_AKT_inhibitor_VIII_3 / 182_Obatoclax Mesylate_2 / 226_GSK1070916_2 pi3k / apop / mitosis 6_163478762_CT_C / 17_46332538_GT_G / 7_74758055_CT_C / 9_100450496_GT_G / 1_176043330_GA_G 60 GRB10_2_11 1014_Refametinib_2 / 1060_PD0325901_2 / 1013_Nilotinib_1 erk_mapk / erk_mapk / abl 12_56425138_C_T / 7_51028450_A_G 61 ZNF415_2_4 286_KIN001-236_3 / 205_Avagacestat_2 / 167_OSU-03012_3 other / other / pi3k 1_225147359_GT_G / 19_1057777_GA_G 62 DMTF1_1_4 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk 1_16758972_T_G 63 MSL2_4_5 226_GSK1070916_2 / 205_Avagacestat_2 / 1050_ZM447439_3 mitosis / other / mitosis 13_37746457_TAA_TA / 8_73582883_GA_G / 5_64507681_TA_T / 7_73465568_GA_G 64 ATP7B_2_6 1013_Nilotinib_1 / 261_TL-1-85_3 / 260_NG-25_3 abl / other / other 5_176347862_G_T / 5_176336593_G_A 65 MANBAL_1_5 305_TPCA-1_3 / 1013_Nilotinib_1 / 155_Ponatinib_2 other / abl / abl 1_24074187_A_G 66 STOX1_1_3 182_Obatoclax Mesylate_2 / 175_PAC-1_2 / 226_GSK1070916_2 apop / apop / mitosis 9_67192757_GA_G 67 PRKCB_2_4 261_TL-1-85_3 / 295_NVP-BHG712_3 / 260_NG-25_3 other / rtk / other 2_68818005_T_G / 1_24074187_A_G 68 PNPLA8_3_5 224_AS605240_3 / 1014_Refametinib_2 / 1526_Refametinib_3 pi3k / erk_mapk / erk_mapk 17_21300996_G_T / 17_21301003_T_C / 17_21301006_A_G 69 ACCS_3_2 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk 11_44107740_C_A / 9_61066407_C_T / 7_135196179_C_T 70 BANP_1_2 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk 9_33270750_G_T 71 ARID1A_2_3 1054_Palbociclib_2 / 1050_ZM447439_3 cell_cyc / mitosis 7_21862122_CT_C / 11_63382198_CA_C 72 ELOVL5_1_4 1013_Nilotinib_1 / 1054_Palbociclib_2 abl / cell_cyc 13_37746457_TAA_TA 73 N4BP2_5_2 175_PAC-1_2 / 257_NPK76-II-72-1_3 apop / mitosis 19_11301321_TA_T / 5_146267624_CT_C / 9_120989554_CT_C / 13_37746457_TAA_TA / 16_84087473_CAA_C 74 LIMS2_5_3 205_Avagacestat_2 / 226_GSK1070916_2 other / mitosis 3_196805277_CT_C / 11_63382198_CA_C / 15_41478441_CT_C / 6_166418092_GA_G / 14_54478163_TA_T 75 DPCD_1_2 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 mitosis / pi3k 15_42211755_GA_G 76 KATNB1_5_2 1006_Cytarabine_1 / 1054_Palbociclib_2 DNArep / cell_cyc 4_183646278_TA_T / 20_38562748_GT_G / 1_84490478_CT_C / 2_200412288_CT_C / X_19006308_TA_T 77 RBM18_1_3 1011_Navitoclax_2 / 1014_Refametinib_2 apop / erk_mapk 10_131944182_G_C 78 EWSR1_1_2 1054_Palbociclib_2 / 226_GSK1070916_2 cell_cyc / mitosis 14_68477626_CT_C 79 SDC4_1_5 245_UNC0638_3 / 196_Phenformin_3 chromatin / metabol 1_24074187_A_G 80 LCK_5_3 182_Obatoclax Mesylate_2 / 175_PAC-1_2 apop / apop 6_163478762_CT_C / 10_70860377_CT_C / 13_37746457_TAA_TA / 5_64507681_TA_T / 5_146267624_CT_C 81 GNA15_1_9 1011_Navitoclax_2 / 226_GSK1070916_2 apop / mitosis 9_33798019_A_G 82 S1PR2_2_8 1014_Refametinib_2 / 224_AS605240_3 erk_mapk / pi3k 1_204261453_G_A / 3_54386725_A_G 83 SOX4_2_2 226_GSK1070916_2 / 1006_Cytarabine_1 mitosis / DNArep 13_37746457_TAA_TA / 6_152444591_GA_G 84 MPP1_1_19 1013_Nilotinib_1 / 263_FR-180204_3 abl / erk_mapk 9_33798019_A_G 85 TRIM26_1_5 277_Linifanib_2 / 1526_Refametinib_3 rtk / erk_mapk 11_129905704_C_T 86 NRN1_2_2 1006_Cytarabine_1 / 175_PAC-1_2 DNArep / apop 20_24959128_C_T / 6_136108863_GA_G 87 PHACTR2_1_4 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk 5_146013801_C_T 88 TRAF3IP2_2_2 1175_Rucaparib_3 / 1017_Olaparib_2 g_integrity / g_integrity 1_149929093_CA_C / 12_27688992_CT_C 89 MLF1IP_1_2 1054_Palbociclib_2 / 1006_Cytarabine_1 cell_cyc / DNArep 10_69097096_G_A 90 PELI2_5_7 226_GSK1070916_2 / 257_NPK76-II-72-1_3 mitosis / mitosis 3_129433338_GT_G / 19_11301321_TA_T / 6_152444591_GA_G / 5_60605865_GA_G / 11_63382198_CA_C 91 HNRNPA1L2_1_2 1054_Palbociclib_2 / 1006_Cytarabine_1 cell_cyc / DNArep 11_33353067_AT_A 92 BCL11B_5_3 205_Avagacestat_2 / 231_FMK_3 other / erk_mapk 13_24781827_GTT_GT / 10_67956845_TA_T / 3_196805277_CT_C / 11_63382198_CA_C / 19_13993876_CT_C 93 TTF1_5_6 226_GSK1070916_2 / 1006_Cytarabine_1 mitosis / DNArep 8_28850105_GA_G / 6_163478762_CT_C / 13_37746457_TAA_TA / 11_63382198_CA_C / 5_146267624_CT_C 94 SKA3_1_2 1054_Palbociclib_2 / 1006_Cytarabine_1 cell_cyc / DNArep 6_163478762_CT_C 95 ECI1_1_2 205_Avagacestat_2 / 1072_Avagacestat_2 other / other 1_247588429_C_G 96 LAPTM4B_1_8 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk 20_56366031_C_T 97 C11orf74_4_5 1014_Refametinib_2 / 1526_Refametinib_3 erk_mapk / erk_mapk 2_237751320_TAA_T / 16_21533198_T_C / 2_216109160_C_A / 16_21520152_G_A 98 RNF24_1_12 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk 5_179863845_T_G 99 CRB3_1_4 1021_Axitinib_2 / 277_Linifanib_2 rtk / rtk 15_98922244_C_T 100 CNTROB_5_3 226_GSK1070916_2 / 1050_ZM447439_3 mitosis / mitosis 16_15068286_TA_T / 5_64507681_TA_T / 8_42906145_TC_T / 3_129433338_GT_G / 1_179120104_GA_G 101 KIAA1967_5_2 211_TL-2-105_3 / 257_NPK76-II-72-1_3 erk_mapk / mitosis 11_107336715_TA_T / 1_22491646_AT_A / 22_23698377_AT_A / 13_37746457_TAA_TA / 3_196805277_CT_C 102 KRT10_1_3 1014_Refametinib_2 / 1526_Refametinib_3 erk_mapk / erk_mapk 7_92671549_C_T 103 VIT_1_2 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / erk_mapk 1_176944072_A_T 104 TMEM173_2_7 1526_Refametinib_3 / 1014_Refametinib_2 erk_mapk / erk_mapk 1_201199371_G_A / 1_201200426_T_G 105 SGCB_1_3 1014_Refametinib_2 / 1015_CI-1040_2 erk_mapk / erk_mapk 17_40035671_A_G 106 DTD1_3_4 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 mitosis / pi3k 5_77411610_TA_T / 2_15396385_GA_G / 11_63382198_CA_C 107 DYSF_1_3 1014_Refametinib_2 / 1015_CI-1040_2 erk_mapk / erk_mapk 1_25390874_C_G 108 AP2S1_1_3 1060_PD0325901_2 / 1372_Trametinib_1 erk_mapk / erk_mapk 10_68572309_C_T 109 EMILIN2_1_11 1526_Refametinib_3 / 1014_Refametinib_2 erk_mapk / erk_mapk 5_179863845_T_G 110 SLC38A1_1_6 1014_Refametinib_2 / 1526_Refametinib_3 erk_mapk / erk_mapk 7_114653804_G_T 111 SGSM2_4_1 226_GSK1070916_2 mitosis 13_97982483_AT_A / 2_63842143_GA_G / 7_77256452_A_G / 4_84631729_G_T 112 ADAM15_1_1 1026_Tanespimycin_2 other 1_75148689_A_T 113 JPH1_2_1 211_TL-2-105_3 erk_mapk 16_81858185_C_G / 5_128345465_A_C 114 S100A8_1_3 1498_Selumetinib_2 erk_mapk 12_11091570_G_A 115 SQSTM1_2_1 182_Obatoclax Mesylate_2 apop 13_24781827_GTT_GT / 19_11301321_TA_T 116 ANXA2_1_1 1026_Tanespimycin_2 other 4_36214492_A_T 117 CMBL_1_2 1013_Nilotinib_1 abl 11_117203393_G_A 118 CABLES2_1_1 1053_MK-2206_2 pi3k 17_74794950_A_G 119 NDST3_2_1 205_Avagacestat_2 other 13_24781827_GTT_GT / 11_90163472_A_C 120 LMNA_1_1 1026_Tanespimycin_2 other 12_120579461_C_T 121 SP1_5_1 333_T0901317_3 other 14_35627049_G_GA / 7_23187041_C_T / 2_61835958_TA_T / X_52753184_G_T / 2_119608507_T_G 122 CDCA7_1_2 1054_Palbociclib_2 cell_cyc 20_46358679_C_G 123 NFYB_1_1 1006_Cytarabine_1 DNArep 20_46358679_C_G 124 SLFN5_2_1 1378_Bleomycin (50uM) _1 DNArep 4_186199057_C_A / 6_116125413_A_G 125 CREG1_3_1 1378_Bleomycin (50uM) _1 DNArep 9_12704725_C_T / 17_47820165_C_A / 17_47819112_T_C 126 DAD1_1_1 1006_Cytarabine_1 DNArep 12_54182016_C_A 127 SURF4_1_4 35_NVP-TAE684_3 rtk 14_101856659_C_G 128 CDK6_1_1 1011_Navitoclax_2 apop 9_33798019_A_G 129 TBCD_5_1 1054_Palbociclib_2 cell_cyc 11_63382198_CA_C / 10_67956845_TA_T / 14_68477626_CT_C / 13_37746457_TAA_TA / 8_73582883_GA_G 130 FLRT3_1_1 1378_Bleomycin (50uM) _1 DNArep 17_8012602_G_A 131 FUCA2_2_1 1526_Refametinib_3 erk_mapk 12_10418492_T_G / 1_3385157_C_T 132 MAPK7_1_1 1054_Palbociclib_2 cell_cyc 7_73465568_GA_G 133 IER3_1_1 1378_Bleomycin (50uM) _1 DNArep 20_62310091_T_G 134 U2AF1_1_1 167_OSU-03012_3 pi3k 9_76023648_GA_G 135 PLA2G12A_1_3 224_AS605240_3 pi3k 1_70189288_A_C 136 CBX2_2_1 1006_Cytarabine_1 DNArep 2_161993434_TA_T / 12_109568919_GT_G 137 MGAT4A_5_1 175_PAC-1_2 apop 13_37746457_TAA_TA / 20_2493490_GA_G / 6_41090123_AT_A / 2_53919250_GA_G / 16_30280420_GA_G 138 STARD10_1_1 1026_Tanespimycin_2 other 20_62327488_A_C 139 CSRNP2_1_1 205_Avagacestat_2 other 22_29978883_CT_C 140 DOK2_2_1 1526_Refametinib_3 erk_mapk 2_23637298_G_A / 2_23642306_G_A 141 VOPP1_1_1 308_WIKI4_2 rtk 22_38427824_A_C 142 PLOD1_1_1 175_PAC-1_2 apop 10_99880039_G_A 143 C3AR1_1_1 1014_Refametinib_2 erk_mapk 7_147977856_A_T 144 CYSLTR1_1_1 1526_Refametinib_3 erk_mapk 11_129905704_C_T 145 S100A6_1_1 1026_Tanespimycin_2 other 12_125519394_A_T 146 ZADH2_1_1 1011_Navitoclax_2 apop 4_86769845_A_G 147 EXOSC9_5_2 167_OSU-03012_3 pi3k 8_108228149_GA_G / 16_57460490_GA_G / 6_31657145_CA_C / 15_50725184_GT_G / 20_33367013_TA_T 148 ZC3H4_2_1 1054_Palbociclib_2 cell_cyc 1_247256362_C_T / 1_247256207_T_C 149 BARD1_1_2 175_PAC-1_2 apop 9_133405414_T_G 150 MCL1_1_1 1011_Navitoclax_2 apop 14_60466034_G_A 151 NINL_3_4 203_BMS-345541_3 other 13_24781827_GTT_GT / 13_37746457_TAA_TA / 11_33353067_AT_A 152 HYI_5_1 226_GSK1070916_2 mitosis 7_151221500_CT_C / 19_1057777_GA_G / 15_42211755_GA_G / 15_34915209_AT_A / 6_30329241_CA_C 153 USP49_1_1 1006_Cytarabine_1 DNArep 7_147638841_CT_C 154 EPB41_1_3 1378_Bleomycin (50uM) _1 DNArep 11_1758992_A_C 155 NFAM1_1_1 1526_Refametinib_3 erk_mapk 9_15848985_C_T 156 SIVA1_5_1 175_PAC-1_2 apop 6_163478762_CT_C / 13_37746457_TAA_TA / 2_161993434_TA_T / 9_120989554_CT_C / 13_39034198_TA_T 157 LRG1_1_2 1026_Tanespimycin_2 other 13_28073352_GA_G 158 TMPRSS15_1 1377_Afatinib_1 egfr 21_39898596_C_A 159 G0S2_1 281_Alectinib_2 rtk 5_35904512_G_T 160 PPIP5K2_2 261_TL-1-85_3 other 2_178769706_G_T / 11_129905704_C_T 161 AGPAT3_4 182_Obatoclax Mesylate_2 apop 17_76289951_CA_C / 2_63842143_GA_G / 13_97982483_AT_A / 12_48679260_CA_C 162 AS3MT_5 226_GSK1070916_2 mitosis 7_20786651_GA_G / 13_24781827_GTT_GT / 7_77937691_AT_A / 3_160416453_CT_C / 5_95507014_TA_T 163 PIK3R3_1 228_AKT_inhibitor_VIII_3 pi3k 2_53919250_GA_G 164 CRY1_2 226_GSK1070916_2 mitosis 19_1057777_GA_G / 9_33798019_A_G 165 ZNF367_1 226_GSK1070916_2 mitosis 12_48679260_CA_C 166 CAV2_3 305_TPCA-1_3 other 12_6952191_A_C / 1_24074187_A_G / 2_68818005_T_G 167 PRKAR2A_5 175_PAC-1_2 apop 13_37746457_TAA_TA / 7_73465568_GA_G / 7_77937691_AT_A / 12_107746489_GT_G / 6_136108863_GA_G 168 CDH3_1 344_THZ-2-49_3 cell_cyc 1_24074187_A_G 169 PCYOX1L_1 271_VNLG / 124_3 chromatin 5_122946014_G_GT 170 RNF13_1 1054_Palbociclib_2 cell_cyc 10_69097096_G_A 171 CD7_2 205_Avagacestat_2 other 5_111103810_A_G / 5_111118983_A_G 172 ZDHHC20_2 190_Bleomycin_1 DNArep 21_38451144_T_G / 11_47588455_A_C 173 LGALS3_1 211_TL-2-105_3 erk_mapk 20_47169235_T_C 174 FANCD2_1 1054_Palbociclib_2 cell_cyc 5_161895646_GT_G 175 TLX2_1 344_THZ-2-49_3 cell_cyc 1_157833087_T_C 176 IFT122_1 1054_Palbociclib_2 cell_cyc 9_33798019_A_G 177 ZNF423_5 175_PAC-1_2 apop 3_9977055_TA_T / 7_77937691_AT_A / 21_32744756_GA_G / 11_63382198_CA_C / 9_120989554_CT_C 178 KDELR1_2 185_Linsitinib_2 igfr 17_62447686_C_T / X_49304797_C_G 179 UFM1_1 282_Pelitinib_2 egfr 8_7811967_A_G 180 ANKRD22_1 281_Alectinib_2 rtk 7_38349808_A_G 181 PLAGL1_3 1526_Refametinib_3 erk_mapk 11_118551711_A_G / 7_93426338_G_A / 16_28902389_G_T 182 ZAP70_5 205_Avagacestat_2 other 13_37746457_TAA_TA / 6_163478762_CT_C / 22_29978883_CT_C / 7_77937691_AT_A / 5_71545270_TA_T 183 OSBPL11_3 1014_Refametinib_2 erk_mapk 17_4896602_C_T / 10_122336546_A_C / 10_122336520_T_C 184 TSPAN7_2 205_Avagacestat_2 other 6_152444591_GA_G / 2_210663103_GTT_GT 185 SPAG7_1 1047_Nutlin-3a (-) _ 2 p53 20_63968004_C_T 186 ABCB10_1 1014_Refametinib_2 erk_mapk 3_52786995_A_G 187 WDR83_4 1236_UNC0638_3 chromatin 16_57460490_GA_G / 14_103670339_GT_G / 1_225147359_GT_G / 16_30280420_GA_G 188 SLC25A29_5 226_GSK1070916_2 mitosis 12_25215659_AT_A / 5_70067144_CA_C / 21_32744756_GA_G / 11_63382198_CA_C / 7_28494775_GT_G 189 SGPP1_1 1526_Refametinib_3 erk_mapk 1_153645034_CT_C 190 CD59_1 271_VNLG / 124_3 chromatin 13_23593366_T_A 191 MRPS21_5 1011_Navitoclax_2 apop 1_148124171_A_G / 1_247841358_T_G / 3_197622346_A_C / 7_100884179_T_G / 11_72220933_A_C 192 ILF2_1 257_NPK76-II-72-1_3 mitosis 19_13993876_CT_C 193 NRM_1 1011_Navitoclax_2 apop 11_4082830_A_C 194 FEM1C_1 1378_Bleomycin (50uM) _1 DNArep 1_15443607_G_A 195 PRCP_1 190_Bleomycin_1 DNArep 3_53179641_T_C 196 P4HB_1 1526_Refametinib_3 erk_mapk 2_71427045_G_A 197 CD44_1 1498_Selumetinib_2 erk_mapk 8_132137720_G_A 198 DCTN4_1 249_Cabozantinib_1 rtk X_3271895_G_A 199 YIPF5_1 275_I-BET-762_3 chromatin 18_63655761_T_C 200 AGPAT2_1 1526_Refametinib_3 erk_mapk 21_25714604_C_A 201 FAM136A_1 1032_Afatinib_1 egfr 16_50711362_A_C 202 TSPAN32_5 271_VNLG / 124_3 chromatin 22_45399045_C_A / 22_45383455_A_G / 22_45322160_A_G / 4_147906782_T_C / 9_32472897_A_G 203 PLA2G16_1 261_TL-1-85_3 other 11_71605554_A_C 204 MET_2 196_Phenformin_3 metabol 11_71605554_A_C / 19_39902109_T_G 205 TMEM97_1 281_Alectinib_2 rtk 2_113939939_A_G 206 ZNF839_1 176_IPA-3_3 cytoskeleton 10_70301448_T_G 207 ERMAP_4 1526_Refametinib_3 erk_mapk 4_25662622_G_A / 2_160137837_C_T / 10_111079134_C_A / 2_160138253_A_G 208 TMEM150A_1 1014_Refametinib_2 erk_mapk 10_88602550_CT_C 209 PDIA5_1 1526_Refametinib_3 erk_mapk 11_18534402_T_C 210 CLIP1_3 1378_Bleomycin (50uM) _1 DNArep 11_24976472_CTGTT_C / 7_1155657_T_TC / 7_1092820_C_T 211 NUDT2_1 55_A-770041_3 other 14_94592125_A_C 212 SMYD2_1 134_Etoposide_1 DNArep 6_26443625_C_A 213 TMPO_1 203_BMS-345541_3 other 10_69097096_G_A 214 ZC4H2_5 226_GSK1070916_2 mitosis 19_1057777_GA_G / 13_91728769_CA_C / 13_24781827_GTT_GT / 16_30280420_GA_G / 7_77937691_AT_A 215 TXLNB_1 1014_Refametinib_2 erk_mapk 20_56366031_C_T 216 CHID1_3 1014_Refametinib_2 erk_mapk 15_78939184_A_AG / 15_78922969_A_C / 1_53250744_G_A 217 TBXAS1_2 1526_Refametinib_3 erk_mapk 1_13104901_G_A / 1_13116020_T_C 218 KLHL25_5 226_GSK1070916_2 mitosis 12_48679260_CA_C / 3_129433338_GT_G / 13_97982483_AT_A / 6_70861991_TA_T / 6_43525297_GT_G 219 CSF3R_5 277_Linifanib_2 rtk 16_57082546_T_C / 9_137986862_A_C / 16_57081660_C_T / 17_7771466_C_T / 17_7801487_C_G 220 SEPHS1_1 182_Obatoclax Mesylate_2 apop 2_232087433_CT_C 221 TRAT1_3 205_Avagacestat_2 other 10_67956845_TA_T / 20_47180038_AT_A / 16_84013157_C_T 222 BET1_1 224_AS605240_3 pi3k 1_1638657_A_G 223 ZNF238_1 1026_Tanespimycin_2 other 2_151617472_C_A 224 BST1_1 1014_Refametinib_2 erk_mapk 3_75338856_G_A 225 CITED4_1 1014_Refametinib_2 erk_mapk 3_75338856_G_A

Results of verification of biomarker responsiveness to blood cancer drugs No. FRH Var_Exp (pval) Var_Drug (pval) Exp_Drug (pval) Ave_VarDrug (pval) Rank One MYB_5 2.44E-11 2.33E-06 / 2.99E-05 / 9.07E-05 / 0.000162263 / 0.000181347 / 0.000222215 / 0.00035849 / 0.000514476 / 0.000545979 / 0.000674184 / 0.000765635 / 0.000770681 / 0.001809532 / 0.001834875 / 0.002399212 / 0.002524974 / 0.002550614 / 0.003470781 / 0.0036125986 / 0.006467757 / 0.006664862 / 0.007101459 / 0.009131449 / 0.009396282 9.43E-05 / 1.18E-09 / 0.000534893 / 1.91E-08 / 2.60E-05 / 2.14E-05 / 0.178381086 / 3.59E-08 / 0.002198223 / 5.01E-09 / 6.92E-07 / 0.003563123 / 2.90E -06 / 0.0012215 / 4.76E-07 / 5.58E-05 / 0.04742754 / 0.011052464 / 0.001638122 / 0.028671936 / 0.334605149 / 2.70E-05 / 0.120451258 / 0.000163666 / 6.58E-06 / 0.028639924 2.70E-03 26 2 CCND3_2 0.0000000001 4.077045608756939e-05 / 0.00024222551880903305 / 0.001033946011968038 / 0.007738992794998014 / 0.0011591447239658929 / 0.00039912025376145785 / 0.02164918938012539 / 6.767691357801751e-06 / 0.000284832520137907 / 0.012017653306794376 / 0.000245369282796154154 1.3348349963172225e-09 / 2.806907767463066e-08 / 1.0352538568715997e-07 / 1.8603881635236497e-07 / 1.1627237502541528e-07 / 3.1401583771073866e-07 / 1.4513640953107782e-06 / 1.658411377465063e-05 / 3.7392462899431575 7.270726435772972e-07 / 1.8069518974781594e-07 / 9.210108427954504e-07 0.003924411 13 3 CLEC11A_2 0.0000000001 0.0005697783607490941 / 0.014056110467957862 / 0.0041011587330335945 / 0.011850911896821052 / 0.0009698603317938078 / 0.04207757694014471 / 0.0027388104840193185 / 0.00017246675352488265 / 0.03592273895483884 / 0.03175705986170069 2.242207521501935e-07 / 8.305985309487528e-07 / 4.8336013623637535e-06 / 9.846343563173533e-08 / 6.35432916630242e-05 / 4.269555689878972e-05 / 8.205338044521348e-05 / 2.020761222821706e-05 / 3.783085835895955e-05554 1.84820 0.014421647 10 4 SLFN11_1 0.0000014885 2.058410044027094e-07 / 3.2782204810649745e-06 / 0.0004160871569071042 / 6.63292779378419e-05 / 0.006637671888814827 / 0.0022180912856278046 / 0.018399047195112327 / 0.008405657307724725 / 6.561891568628848e-09 2.149510966621969e-13 / 1.511769414105504e-12 / 5.5112514063494236e-11 / 1.4108104414924931e-11 / 2.0143854426093352e-07 / 4.658955213551342e-08 / 8.06522811486229e-08 / 7.925927909364347e-07 / 2.303130551346628e-06 0.004016264 9 5 GLUL_1 0.0000002831 0.00023185717108361177 / 0.006750424182996093 / 0.0002804552471714009 / 0.0005780064318768233 / 0.013252364717981309 / 1.0437921127925209e-05 / 0.0007062900199205474 4.534423217653711e-06 / 3.2067677278063803e-07 / 1.3129666358688659e-07 / 2.6699938480633866e-07 / 2.004464466602968e-06 / 0.00014802121084993243 / 7.828884449821822e-06 0.003115691 7 6 ARRB1_1 0.0000033954 0.0002804552471714009 / 0.0005780064318768233 / 0.010567003405101198 / 0.014937099801101831 / 0.01674887186117834 / 1.0437921127925209e-05 / 0.00023185717108361177 1.4696888618625038e-06 / 3.112710641578339e-05 / 1.247822961432111e-06 / 3.477116300776317e-06 / 0.00011575707789856708 / 0.0008336548513620248 / 0.0016450159858039666 0.00619339 7 7 UBASH3B_1 0.0000018468 0.0002995789665935157 / 0.0040572780204219784 / 0.005622638162586019 / 0.0058415461692228185 / 0.012034946659617903 / 0.021088961594331778 / 0.01327523933544239 4.724411278108721e-08 / 4.074534670810025e-07 / 3.742229484811863e-08 / 1.929959476498321e-06 / 9.208079400238424e-07 / 1.5168095717056432e-05 / 0.00010044442526903786 0.008888598 7 8 TNFRSF1A_2 0.0000000156 0.006712933497164321 / 0.00734125603680501 / 0.03443695791574148 / 0.018289424799019176 / 0.0009354534478970254 / 0.03357668476840166 / 0.007912796162920774 4.5437268485007956e-12 / 9.62085159236817e-09 / 5.689408914135723e-10 / 2.0274308401802066e-09 / 8.235496674010025e-08 / 1.2678212837654556e-05 / 8.896726535766315e-06 0.015600787 7 9 FLT3_1 0.0000001451 0.003147802426563143 / 0.04222939169807093 / 0.02231188189092723 / 0.029744514791248327 / 0.028609215461963253 / 0.014219370494597181 / 0.014883090519715167 0.0012185301703030475 / 0.0002548917231763184 / 0.010959181924780034 / 2.4351732992736147e-06 / 5.5554978038046984e-05 / 0.0009499267638480247 / 0.013113311745609578 0.02216361 7 10 TAF3_1 0.0000001041 1.571192550615105e-05 / 1.941083369182502e-05 / 0.0005612205331984135 / 0.0014877407788245077 / 5.841226151846549e-05 / 0.0007872693710314749 1.0270513426028016e-06 / 2.275418199134362e-06 / 5.376973880229442e-07 / 5.440513967426541e-05 / 4.007754879249793e-05 / 9.814569472587485e-06 0.000488294 6 11 RNF169_1 0.0000003217 0.01436512323945228 / 0.0006014109163865767 / 0.0001378888342129313 / 0.0002929996205947111 / 0.007650609737897124 / 0.0005428574293301743 0.0010596490798711214 / 0.00033866528188749375 / 5.121947955378021e-05 / 5.927440166657884e-05 / 6.948929572951347e-06 / 2.3120988018089485e-05 0.003931815 6 12 AGTRAP_1 0.0000023662 0.0027034438550029654 / 0.0016457734962318454 / 0.014533062562870484 / 0.02599605804689892 / 0.0024801934991487765 / 0.009546895754403102 1.646452812514797e-07 / 5.834785414810817e-09 / 2.228307124314093e-06 / 5.569491755748062e-05 / 2.3571084667936895e-07 / 0.0003782361834351102 0.009484238 6 13 DDX60L_1 0.0000004163 0.008667427627946265 / 0.006966556160504672 / 0.002473974378703085 / 0.016468758578796875 / 0.004255262005017205 / 0.025751753175331515 2.1944492060454965e-10 / 8.933493156895685e-11 / 2.0506277272462366e-08 / 1.215047380695114e-10 / 7.747481723739867e-10 / 1.3299778330505356e-06 0.010763955 6 14 MARCH9_1 0.0000028687 0.008696629436037122 / 0.015715958080688867 / 0.014693978334844182 / 0.007641325545186426 / 0.01903807829299923 / 0.02673662083221299 2.0837934472912685e-10 / 3.483396562503217e-08 / 4.9563854817943744e-06 / 1.1230784085451434e-07 / 4.956418832931685e-07 / 6.827219227535627e-05 0.015420432 6 15 OSBPL5_1 0.0000008435 0.0261982361091171 / 0.030902579554522257 / 0.005200674803908244 / 0.01749894538092688 / 0.0006032976474312159 / 0.02092310744702267 5.453427993682317e-09 / 3.766985952770836e-07 / 1.2761924650567061e-06 / 7.72434990386913e-06 / 1.4070385044464016e-05 / 3.4211990088426983e-05 0.016887807 6 16 ZNF22_1 0.0003669254 0.004371760349727022 / 0.0099226754908213 / 0.010321671240407263 / 0.011325776736179346 / 0.044537859106021475 / 0.025680963996521974 2.5184177279829715e-06 / 1.636959244332829e-05 / 9.28253424535522e-06 / 2.0181236604145942e-05 / 1.6154147530836813e-08 / 1.1540056394143666e-05 0.017693451 6 17 DGAT1_3 0.0000000002 0.003920312673863002 / 0.033716279024290426 / 0.028856747132498983 / 0.001891302386162808 / 0.0334381808514423 / 0.04828281984464098 8.140369229025295e-09 / 5.289386858277019e-09 / 3.985757315136653e-06 / 1.144807405715584e-06 / 1.0254993066544188e-07 / 5.67274705848272e-07 0.025017607 6 18 ORMDL3_2 0.0000000026 0.0001300233129794514 / 0.00012978314275476224 / 0.0012778350943993954 / 0.0029565776361184853 / 7.156767789831989e-05 4.677646164059941e-05 / 1.7503293191137602e-05 / 0.00021751510293843788 / 0.0007155675311678111 / 0.0004230167122498104 0.000913157 5 19 ROPN1L_2 0.0000000992 0.0018394467371983382 / 0.00913487358238157 / 0.0049023855394268795 / 0.026316021782540434 / 0.0004368255106696828 1.65748500527577e-06 / 2.69948847247789e-06 / 3.4467469699377065e-06 / 8.914027666915662e-05 / 4.187857920242108e-05 0.008525911 5 20 MSI2_1 0.0000007794 0.0002529667144490502 / 0.00036391652177154756 / 0.02345731242786629 / 0.019126121819567174 / 0.0033080493995101515 7.391397953437064e-07 / 4.9426454303194644e-08 / 1.2647772425190535e-05 / 1.2578560206261788e-05 / 0.0003891280853340393 0.009301673 5 21 PSTPIP2_2 0.0000011641 0.01858959254693148 / 0.0057681381434131025 / 0.015399266745073165 / 0.01166420660727075 / 0.004242395710111552 6.507094545128767e-09 / 1.7105362633772053e-06 / 8.11163443332903e-09 / 8.384249213928925e-09 / 2.7206056643566975e-06 0.01113272 5 22 MYL6B_1 0.0000017698 0.013119151423196779 / 0.012200296617999914 / 0.02306053904486267 / 0.011416714879054282 / 0.01303162671001627 1.3311228115309853e-10 / 2.1189280513945988e-08 / 2.608386936275246e-06 / 4.4163387400701993e-07 / 1.2403225638581886e-06 0.014565666 5 23 LPAR6_2 0.0000010413 0.04483307027122483 / 0.016219042044394588 / 0.016746868284220093 / 0.00486964278014844 / 0.011545690725925754 3.55398091991154e-07 / 3.727072342882139e-06 / 8.612792966957608e-06 / 2.5049632841227237e-05 / 0.0002242378619733357 0.018842863 5 24 RIPK2_5 0.0000090083 0.02265948210195236 / 0.035801285983055375 / 0.013949514732498905 / 0.03916661845542834 / 0.010906005384287334 2.1349289386986835e-07 / 6.970901169252273e-06 / 0.0001261364550401567 / 0.000139252106012186 / 0.0001754023039229962 0.024496581 5 25 KIF15_1 0.0000003279 0.0001767131207877772 / 0.0020841717587245586 / 0.004354818985686167 / 0.003594625784570769 3.8166356839184545e-08 / 7.55812749192087e-08 / 8.424093350919768e-09 / 1.7417317886126239e-06 0.002552582 4 26 ATP11A_2 0.0000000003 0.0020192776408069777 / 0.0014905987749008023 / 0.013592511172070427 / 0.011492354840434907 3.060704654994384e-08 / 1.3622595470762118e-06 / 1.1997422693515186e-05 / 2.3355709465331877e-05 0.007148686 4 27 ZYX_1_9 0.0002544084 0.018753885801507886 / 0.005311083771261927 / 0.006409025340802752 / 0.005160774238426144 4.184364793482633e-08 / 2.790592162598525e-08 / 4.0166122353119465e-05 / 1.8565339769963503e-05 0.008908692 4 28 SNRPG_5_5 0.0000089357 0.007921660193554354 / 0.02167583393151509 / 0.010388347521304256 / 0.004658316663498735 3.551868821203453e-05 / 0.00013168055697875434 / 6.548534863709185e-06 / 0.0005681263502070304 0.01116104 4 29 RABGAP1_4_4 0.0000000240 9.003720907011053e-06 / 3.3390115236034044e-05 / 0.00010269468011156112 / 0.047149137178743444 2.8234052288359836e-11 / 1.0277712264139365e-09 / 4.49119651999139e-09 / 2.1963432700833613e-06 0.011823556 4 30 AEBP1_5_4 0.0000000706 0.036562724183920495 / 0.0028825516275127186 / 0.00160056713944595 / 0.011492031900646014 1.9554526130426222e-07 / 1.552879261624138e-05 / 4.179984189724783e-07 / 8.30585388888977e-05 0.013134469 4 31 HNRNPA0_5_7 0.0000000001 0.02460227458303824 / 0.004665409573481128 / 0.030772288525987988 / 0.001787886444312416 6.020361445492525e-07 / 1.741544026523412e-07 / 5.73570311140249e-07 / 6.770166211380507e-06 0.015456965 4 32 PVRL2_1_15 0.0040605369 0.009602522264793944 / 0.009289808589253353 / 0.018424979456259774 / 0.024543614212947564 1.124934929019874e-11 / 8.232216311317465e-10 / 1.9664830084576235e-07 / 4.469619906576272e-09 0.015465231 4 33 KIAA1377_1_4 0.0000081593 0.018039249363489208 / 0.024808081702847627 / 0.015360074710325671 / 0.006240332233062281 7.596479317713833e-09 / 6.788792995710976e-08 / 1.35168996872219e-07 / 2.1659140645524504e-08 0.016111935 4 34 THEM4_5_4 0.0000000056 0.007883092210604252 / 0.045211602878352866 / 0.013149940565499176 / 0.005780083414189651 4.830559480901911e-08 / 7.6434613644282e-08 / 1.0166377279715499e-05 / 5.88015987182058e-07 0.01800618 4 35 RBM15B_4_4 0.0000007681 0.0009381311035088946 / 0.03970456788745093 / 0.028253326379734534 / 0.006515747132785524 1.3038025544377534e-07 / 2.059062830566604e-07 / 4.983244116392506e-06 / 6.51433835861991e-05 0.018852943 4 36 C10orf11_1_7 0.0003082937 0.02543028371249526 / 0.04598785527902361 / 0.015049388659828227 / 0.023622920144404418 7.259417399792894e-07 / 7.365037376695162e-06 / 2.047194651689395e-05 / 0.0002797495873085723 0.027522612 4 37 NSMAF_1_7 0.0000032686 0.022251914845713937 / 0.04748951355240249 / 0.048345822890961225 / 0.01793479538407506 2.9254934132272395e-07 / 6.623060722446782e-06 / 5.831321946385646e-07 / 0.0022213483241615155 0.034005512 4 38 FRAT2_2_9 0.0000008562 0.0469875036346009 / 0.03110964092628252 / 0.028109447152411662 / 0.04417620834797813 3.3044879183409916e-06 / 9.1345152872844e-06 / 8.429737657625968e-06 / 1.855611509886761e-05 0.0375957 4 39 LRPAP1_2_3 0.0000000010 5.8572126941774705e-06 / 3.043966989607747e-06 / 4.7114539866525214e-06 1.9971265139787018e-07 / 8.389633993572189e-07 / 4.782132344940121e-05 4.53754E-06 3 40 PRAM1_3_3 0.0000000000 7.723544457794067e-05 / 0.00043689278876896613 / 6.689338676878303e-05 0.00010570433563924172 / 0.007095334821012586 / 0.00012642089180450603 0.000193674 3 41 RAG1_2_3 0.0000000001 0.0005257240065993557 / 0.0002394716728524391 / 0.0025629535017791943 5.592836211795487e-07 / 4.514859891307818e-06 / 0.00031448434878023827 0.001109383 3 42 CARHSP1_2_3 0.0000000916 7.622564649516217e-05 / 0.0009833215694022874 / 0.0024720664729962283 2.124059305243635e-07 / 0.00011446446711497937 / 7.575581180621143e-05 0.001177205 3 43 MBLAC1_1_3 0.0000002897 0.001629254700856046 / 0.007145353467565649 / 0.003740996699493107 2.6740655179081655e-06 / 5.483995787755592e-05 / 9.450515390044369e-06 0.004171868 3 44 RAG2_3_4 0.0000000033 0.006629188877801916 / 0.0035201246516142408 / 0.007903236560929908 9.394932445113252e-06 / 6.847563888114024e-07 / 3.436655016403447e-06 0.006017517 3 45 HNMT_1_4 0.0000109002 0.01445558317701132 / 0.002106973677295091 / 0.0051161594672994425 0.0009692764104023793 / 0.003012779171399397 / 0.0024376724564066005 0.007226239 3 46 KCTD7_2_5 0.0000002604 0.020616294446739954 / 0.00021206125966908608 / 0.0009033836310563283 8.885033400689205e-08 / 2.389820509715415e-08 / 1.552864015973841e-06 0.007243913 3 47 GSN_1_6 0.0000451573 0.018753885801507886 / 0.005160774238426144 / 0.005311083771261927 1.4722017530591616e-07 / 2.9874753250046506e-06 / 0.0002124927996391344 0.009741915 3 48 CBFB_2_5 0.0000000001 0.003275583453177208 / 0.011330483320304221 / 0.01982909497763039 2.0245259136355526e-08 / 1.1456344413276593e-07 / 2.816265834361234e-06 0.011478387 3 49 FBXO33_1_4 0.0000001371 0.0023176777492038073 / 0.0077384325604461434 / 0.028530012205593615 1.072142034599158e-06 / 5.345226496779758e-06 / 8.792028909123797e-05 0.012862041 3 50 ZBED4_2_4 0.0000000002 0.00012909510564440324 / 0.027672452276552212 / 0.021025463475859662 9.434784549401446e-08 / 1.0143923768921633e-06 / 4.495391600951897e-06 0.01627567 3 51 COPS8_5_6 0.0000043601 0.0031977499264920816 / 0.0058949672009652055 / 0.0415421191636228 6.858069673230018e-10 / 4.518917447441741e-08 / 2.2871232096910657e-06 0.016878279 3 52 ISG20_1_12 0.0000001188 0.035870034304549374 / 0.006915099173258228 / 0.011599763066790982 4.0742030661470875e-09 / 3.5704180408306135e-05 / 2.6235380954232833e-06 0.018128299 3 53 LGALS12_3_4 0.0000000247 0.003840056352113353 / 0.04492920892897124 / 0.006327629664955956 1.3156520171567348e-06 / 2.8564954858549742e-05 / 1.2400627667338633e-05 0.018365632 3 54 SNRNP48_5_3 0.0000000018 0.010494026299769539 / 0.043808945731610247 / 0.0014402699590059412 2.99777252070361e-08 / 9.372440209809473e-07 / 1.6303080292790598e-06 0.018581081 3 55 VPS37C_3_4 0.0000000002 0.015575058031697179 / 0.022954263288630178 / 0.019211836869592394 1.1893807531811264e-07 / 4.436107889122841e-07 / 2.596755422338286e-05 0.019247053 3 56 ATP6V0A1_1_3 0.0000019232 0.000953280912166266 / 0.048984014938993056 / 0.009090139199551346 3.96290085102306e-06 / 5.2636828189880915e-05 / 2.713261376319351e-06 0.019675812 3 57 HEATR5A_5_6 0.0000002878 0.007823565564916568 / 0.0292814900476121 / 0.02260169832848745 8.824452322000626e-09 / 8.736451088889874e-07 / 3.993788450977646e-06 0.019902251 3 58 ENG_2_8 0.0000000000 0.03439309599730442 / 0.026001527500775657 / 0.0004074623263257791 3.7930066913887975e-05 / 2.6178770339186957e-06 / 3.208634906990993e-05 0.020267362 3 59 USF1_5_7 0.0000000001 0.021841208862304992 / 0.020652548829715695 / 0.021917069763045867 7.175376098186409e-08 / 2.6998472948345092e-08 / 3.909927527606591e-07 0.021470276 3 60 GRB10_2_11 0.0000185139 0.01872961470434043 / 0.02675787024949966 / 0.02145205112846333 1.2669785337002742e-06 / 3.145604382649769e-05 / 0.003268778879566519 0.022313179 3 61 ZNF415_2_4 0.0000000549 0.034523433022212606 / 0.002626392249292539 / 0.03171232908110631 0.00011739915632689058 / 0.00032821497481615343 / 0.0006546049761514156 0.022954051 3 62 DMTF1_1_4 0.0000031099 0.014324360736687866 / 0.014925670621200341 / 0.04696641107757261 1.4288355402449756e-08 / 1.4596250772642315e-06 / 5.309179790067734e-07 0.025405481 3 63 MSL2_4_5 0.0000015252 0.037843536087373564 / 0.028245718557519638 / 0.010417492228432875 8.258866166846628e-08 / 0.0002798921759421857 / 1.2286864638985527e-05 0.025502249 3 64 ATP7B_2_6 0.0000857095 0.019438518423424804 / 0.04009632870085458 / 0.019672456709775226 0.005743135091223456 / 0.0021129104763862407 / 0.00504181900162891 0.026402435 3 65 MANBAL_1_5 0.0010263664 0.04759200231032889 / 0.013410196167242377 / 0.021153975401583373 0.0006029756140517701 / 0.00041293727100713963 / 0.0005679619453748995 0.027385391 3 66 STOX1_1_3 0.0000006884 0.03863925234050396 / 0.03290414475660668 / 0.03755706426028869 3.498492394676035e-07 / 3.760551753407323e-07 / 2.1838711309964997e-05 0.03636682 3 67 PRKCB_2_4 0.0036722126 0.03636552435344791 / 0.0455393445167841 / 0.028719427176232087 0.0017342974389574256 / 0.0002954473217666082 / 0.0019265906505422808 0.036874765 3 68 PNPLA8_3_5 0.0007762216 0.042906002207961834 / 0.03376346011476386 / 0.04533268492631154 1.8682120741176118e-07 / 3.889932908773882e-08 / 9.103372671114004e-06 0.040667382 3 69 ACCS_3_2 0.0000000228 0.001351396866557077 / 0.0010059530260990539 4.958979360917343e-05 / 0.0023766001705639063 0.001178675 2 70 BANP_1_2 0.0000005192 0.0019949596708715915 / 0.0016405254782622762 1.8954349923575262e-08 / 2.9663347375425656e-07 0.001817743 2 71 ARID1A_2_3 0.0000370373 0.0002225245598561803 / 0.003462048449780649 2.8835181082720374e-06 / 8.852299874117299e-06 0.001842287 2 72 ELOVL5_1_4 0.0000080768 0.0039737550720910855 / 0.0005677614392890738 1.767738685972929e-05 / 5.339450136972672e-05 0.002270758 2 73 N4BP2_5_2 0.0000006959 0.0015260933937112297 / 0.0030693630789256784 8.782349802931962e-08 / 1.8514757097012648e-06 0.002297728 2 74 LIMS2_5_3 0.0000000063 0.0016929672723561087 / 0.008211724439767342 0.0016526205911910397 / 0.00010998980798238088 0.004952346 2 75 DPCD_1_2 0.0001195622 0.010348808383695646 / 0.0010576116241639605 3.4139161518097934e-06 / 5.8072556519062024e-05 0.00570321 2 76 KATNB1_5_2 0.0000003099 0.0019502509185472647 / 0.011870363561574568 6.469316636849928e-07 / 1.4319474206641112e-06 0.006910307 2 77 RBM18_1_3 0.0000183263 0.01202180554894753 / 0.0035996788619062025 2.314655750329529e-05 / 1.6273301545995376e-05 0.007810742 2 78 EWSR1_1_2 0.0000001571 0.012034946659617903 / 0.0040572780204219784 4.353930633746647e-07 / 1.4940958130887165e-07 0.008046112 2 79 SDC4_1_5 0.0234952285 0.012910722002948388 / 0.003241368623522047 0.0023789084931403904 / 2.15445169218155e-05 0.008076045 2 80 LCK_5_3 0.0000000635 0.008161592461102153 / 0.008111725160704844 5.0045516393587565e-08 / 2.5329814927720417e-06 0.008136659 2 81 GNA15_1_9 0.0000088925 0.0025023165322416653 / 0.015816246241733566 1.2297735264773097e-09 / 2.212465069137835e-05 0.009159281 2 82 S1PR2_2_8 0.0000000000 0.019132559438094155 / 3.0373671784422295e-05 8.259862596669298e-06 / 3.850434675370876e-06 0.009581467 2 83 SOX4_2_2 0.0000001046 0.0027896864342722566 / 0.018314702453390137 1.3593400126131383e-06 / 3.4858545482237707e-06 0.010552194 2 84 MPP1_1_19 0.0000010744 0.0025023165322416653 / 0.019031746930740782 6.468408975112741e-07 / 4.501092888023762e-06 0.010767032 2 85 TRIM26_1_5 0.0000259348 0.005311083771261927 / 0.018753885801507886 2.1060691141971387e-05 / 8.874237350648491e-05 0.012032485 2 86 NRN1_2_2 0.0000003469 0.011538246690417763 / 0.013237230739493226 4.568675707352792e-05 / 3.561238367689432e-05 0.012387739 2 87 PHACTR2_1_4 0.0000005718 0.023477467429053465 / 0.0031820555262817535 8.883753710042578e-09 / 3.719669014236788e-08 0.013329761 2 88 TRAF3IP2_2_2 0.0000002512 0.0007576193165839696 / 0.027287848272635487 6.910884434287362e-05 / 0.0005161273618227694 0.014022734 2 89 MLF1IP_1_2 0.0000000269 0.01425257865031356 / 0.013908722253004258 2.3242551216769015e-07 / 2.032446141420201e-07 0.01408065 2 90 PELI2_5_7 0.0000007941 0.024350309684056323 / 0.0040259990419718224 1.6694115297250117e-05 / 4.29829826110023e-06 0.014188154 2 91 HNRNPA1L2_1_2 0.0013250663 0.011811366692668503 / 0.01996564314234407 6.032224635469657e-06 / 0.00022917080156904956 0.015888505 2 92 BCL11B_5_3 0.0000002152 0.0010839847636384084 / 0.0314544685608876 1.5333271595229285e-05 / 5.898660325189134e-05 0.016269227 2 93 TTF1_5_6 0.0000000000 0.029170441459925932 / 0.005632866448663831 5.197029616318252e-06 / 3.552041331603543e-05 0.017401654 2 94 SKA3_1_2 0.0000017003 0.02944327994687945 / 0.006711372368467916 7.293595674464534e-07 / 6.073859065512907e-06 0.018077326 2 95 ECI1_1_2 0.0000229019 0.035232086909202764 / 0.004224402787232246 0.0006535889942974735 / 1.0760030207436584e-05 0.019728245 2 96 LAPTM4B_1_8 0.0005057964 0.038858943917955066 / 0.0026332591769253765 8.316897145333996e-07 / 0.0026794799237590664 0.020746102 2 97 C11orf74_4_5 0.0000166404 0.0065634419527186095 / 0.035907170503621015 2.3323526700006173e-07 / 3.9706288089173614e-08 0.021235306 2 98 RNF24_1_12 0.0000007106 0.035870034304549374 / 0.006915099173258228 7.35322340702987e-10 / 2.1643712587488395e-06 0.021392567 2 99 CRB3_1_4 0.0001229934 0.0007511098393260164 / 0.04383341877435241 0.003519521269349817 / 0.00041067349827126156 0.022292264 2 100 CNTROB_5_3 0.0000000247 0.039985574714404205 / 0.006604515441249478 2.807079453207472e-06 / 6.0843943238096606e-06 0.023295045 2 101 KIAA1967_5_2 0.0000000000 0.03731581709317308 / 0.012775853621628915 5.8098057666508814e-05 / 1.4846660294438575e-05 0.025045835 2 102 KRT10_1_3 0.0000036294 0.0026276752303615626 / 0.04816709797976521 2.3292547237816868e-07 / 1.1196213690475162e-05 0.025397387 2 103 VIT_1_2 0.0000022102 0.029787982806896113 / 0.032221265722000465 0.00017866575515019837 / 0.0002927226669085562 0.031004624 2 104 TMEM173_2_7 0.0000013775 0.04752560036471882 / 0.021645143900361517 9.96917291837022e-10 / 3.7449827724309687e-05 0.034585372 2 105 SGCB_1_3 0.0000001520 0.04565488150522094 / 0.02362203677270414 1.1745686994413256e-07 / 2.146978330026032e-06 0.034638459 2 106 DTD1_3_4 0.0000046923 0.04395039131441785 / 0.025938330717151792 2.2711346209436874e-06 / 5.0656566660967563e-05 0.034944361 2 107 DYSF_1_3 0.0000126202 0.0339445086192224 / 0.03749998396549492 1.097257076002153e-06 / 3.4300052428458304e-05 0.035722246 2 108 AP2S1_1_3 0.0000000192 0.04966114977300441 / 0.025208249293274098 9.67952519324101e-06 / 5.812467299823981e-06 0.0374347 2 109 EMILIN2_1_11 0.0000004298 0.035870034304549374 / 0.04080808705746035 3.9151610584341596e-05 / 0.0034531579985310175 0.038339061 2 110 SLC38A1_1_6 0.0000051639 0.04291927548525659 / 0.04100450439141127 0.00021587157297136373 / 7.315015547583871e-06 0.04196189 2 111 SGSM2_4_1 0.0000000000 1.8562520247073517e-06 1.2613994263920118e-05 1.85625E-06 One 112 ADAM15_1_1 0.0000043982 2.1108944769046428e-05 4.681342411309229e-05 2.11089E-05 One 113 JPH1_2_1 0.0000000278 7.575574348900015e-05 3.941680513177924e-06 7.57557E-05 One 114 S100A8_1_3 0.0000014212 0.00016898721560974943 0.00029401372690121037 0.000168987 One 115 SQSTM1_2_1 0.0000005259 0.00017867345021532058 9.669186962307088e-08 0.000178673 One 116 ANXA2_1_1 0.0002075934 0.0006183619071556604 6.009170462268738e-07 0.000618362 One 117 CMBL_1_2 0.0000903757 0.0006632986409284882 0.0009716339098724625 0.000663299 One 118 CABLES2_1_1 0.0000005356 0.0009735838558541434 1.5864345356463386e-06 0.000973584 One 119 NDST3_2_1 0.0001935195 0.0013385816312795275 0.004242951596879371 0.001338582 One 120 LMNA_1_1 0.0001346708 0.0013680275764369084 1.8919816110190497e-07 0.001368028 One 121 SP1_5_1 0.0000000097 0.0016246578528363023 0.003568784039880526 0.001624658 One 122 CDCA7_1_2 0.0000002357 0.001651752731778548 3.2201603349527115e-08 0.001651753 One 123 NFYB_1_1 0.0000079306 0.001651752731778548 2.9900676055211447e-06 0.001651753 One 124 SLFN5_2_1 0.0000000019 0.0019030049715582106 1.6941578744438862e-06 0.001903005 One 125 CREG1_3_1 0.0000000008 0.002054415410594919 7.20016447767814e-08 0.002054415 One 126 DAD1_1_1 0.0000006548 0.0023044700596710713 2.075870685180039e-05 0.00230447 One 127 SURF4_1_4 0.0001169460 0.0023462063828761834 2.694050289871364e-06 0.002346206 One 128 CDK6_1_1 0.0000006851 0.0025023165322416653 4.988905197611986e-08 0.002502317 One 129 TBCD_5_1 0.0000000036 0.002561276140915946 2.9892584316614904e-05 0.002561276 One 130 FLRT3_1_1 0.0002800458 0.002583315109010803 5.49167223817782e-07 0.002583315 One 131 FUCA2_2_1 0.0000025095 0.002692404935612982 1.2127488828322545e-08 0.002692405 One 132 MAPK7_1_1 0.0000080829 0.0027910840567973052 3.572472659968713e-06 0.002791084 One 133 IER3_1_1 0.0000013686 0.003048257034885675 4.950876200499383e-07 0.003048257 One 134 U2AF1_1_1 0.0000711501 0.0034457838678580263 4.61837154254303e-05 0.003445784 One 135 PLA2G12A_1_3 0.0000038708 0.0037441061510198473 2.729672667763293e-06 0.003744106 One 136 CBX2_2_1 0.0000000018 0.004184305915812207 5.9615623663426e-06 0.004184306 One 137 MGAT4A_5_1 0.0000000380 0.004222683731586138 8.335124351148404e-06 0.004222684 One 138 STARD10_1_1 0.0000111851 0.004248732743058664 1.7842777216078496e-05 0.004248733 One 139 CSRNP2_1_1 0.0006867668 0.004513557106243546 0.0027185421381640293 0.004513557 One 140 DOK2_2_1 0.0000003678 0.004572328568472603 1.1556890898941218e-07 0.004572329 One 141 VOPP1_1_1 0.0000001536 0.004906926404956519 6.909057066591582e-07 0.004906926 One 142 PLOD1_1_1 0.0000003727 0.005173685415892114 3.142318025848709e-07 0.005173685 One 143 C3AR1_1_1 0.0000020129 0.005257465843641482 2.3396828250233102e-05 0.005257466 One 144 CYSLTR1_1_1 0.0000173361 0.005311083771261927 4.033605569704644e-05 0.005311084 One 145 S100A6_1_1 0.0000725809 0.005362813680576461 5.537142752723009e-07 0.005362814 One 146 ZADH2_1_1 0.0000007439 0.005446188106227207 4.5754730268930877e-07 0.005446188 One 147 EXOSC9_5_2 0.0000000031 0.005557108169871316 0.0008987664165136352 0.005557108 One 148 ZC3H4_2_1 0.0000015162 0.0056341770524356806 2.473933719190643e-06 0.005634177 One 149 BARD1_1_2 0.0001823376 0.006165167235416857 1.190027150355448e-06 0.006165167 One 150 MCL1_1_1 0.0000001874 0.007100868378374273 4.0192784636893195e-10 0.007100868 One 151 NINL_3_4 0.0002849953 0.0075283603267041295 0.00041052511652349915 0.00752836 One 152 HYI_5_1 0.0000017676 0.0075586596774093046 1.819350673029577e-06 0.00755866 One 153 USP49_1_1 0.0001312429 0.008755239263851211 3.964656691897526e-06 0.008755239 One 154 EPB41_1_3 0.0001006328 0.009034882970510456 0.00013511214683115084 0.009034883 One 155 NFAM1_1_1 0.0022752255 0.00930978531173234 0.002292669227147625 0.009309785 One 156 SIVA1_5_1 0.0000000190 0.00976422285866606 7.911319869760405e-07 0.009764223 One 157 LRG1_1_2 0.0000001990 0.009927973270752382 2.608540917049233e-06 0.009927973 One 158 TMPRSS15_1 0.0006841749 0.01024047346065129 0.0015664204162032947 0.010240473 One 159 G0S2_1 0.0000299702 0.010257439205265872 8.408868136136204e-05 0.010257439 One 160 PPIP5K2_2 0.0000000004 0.010428331358146754 3.5879660652504166e-05 0.010428331 One 161 AGPAT3_4 0.0000001930 0.012409468524965496 5.951529459390704e-06 0.012409469 One 162 AS3MT_5 0.0000000636 0.012507967443150024 5.2069842035903486e-05 0.012507967 One 163 PIK3R3_1 0.0000004378 0.012693846370002933 1.1134112040621844e-05 0.012693846 One 164 CRY1_2 0.0000000015 0.01273908719327046 1.0364125026792716e-05 0.012739087 One 165 ZNF367_1 0.0000007429 0.012817165427214991 1.6554871434804345e-06 0.012817165 One 166 CAV2_3 0.0000900165 0.013003562519067686 0.0003165314040118799 0.013003563 One 167 PRKAR2A_5 0.0000000095 0.01304625461905942 1.165198476893287e-06 0.013046255 One 168 CDH3_1 0.0045171197 0.013410196167242377 0.0007156791563689302 0.013410196 One 169 PCYOX1L_1 0.0000134838 0.013753446987297501 1.9648507707958793e-05 0.013753447 One 170 RNF13_1 0.0000015479 0.01425257865031356 1.4173074929245687e-06 0.014252579 One 171 CD7_2 0.0000009350 0.01439564075722508 7.429143195372626e-05 0.014395641 One 172 ZDHHC20_2 0.0001740391 0.015206312141533855 4.602813943558735e-05 0.015206312 One 173 LGALS3_1 0.0000060213 0.015392940222320921 1.0628836539660367e-05 0.01539294 One 174 FANCD2_1 0.0000121545 0.015451637722969586 1.8831841564871015e-06 0.015451638 One 175 TLX2_1 0.0000038270 0.01579251142156246 0.00030858470095783614 0.015792511 One 176 IFT122_1 0.0000002512 0.015816246241733566 1.0290413092804304e-06 0.015816246 One 177 ZNF423_5 0.0000000005 0.01687645691903394 6.82889444974133e-05 0.016876457 One 178 KDELR1_2 0.0000093509 0.017039557735435966 0.0033303362491578807 0.017039558 One 179 UFM1_1 0.0000305210 0.01740310378263097 1.2418583024568846e-07 0.017403104 One 180 ANKRD22_1 0.0041854861 0.018007630833331033 0.03752163881197765 0.018007631 One 181 PLAGL1_3 0.0000021368 0.018069182178099105 3.851073571966146e-09 0.018069182 One 182 ZAP70_5 0.0000000009 0.018364208164662808 6.653729445177915e-06 0.018364208 One 183 OSBPL11_3 0.0000067843 0.018433344261519963 9.808098956813373e-09 0.018433344 One 184 TSPAN7_2 0.0004599184 0.018664165174459613 0.0021706260770740027 0.018664165 One 185 SPAG7_1 0.0000103437 0.01887978871098741 3.5786939909329174e-07 0.018879789 One 186 ABCB10_1 0.0000008268 0.019394963522372948 7.395897405399312e-06 0.019394964 One 187 WDR83_4 0.0000057993 0.019553853323608723 0.0007136717421366572 0.019553853 One 188 SLC25A29_5 0.0000000015 0.019638512683722072 9.869448477453816e-08 0.019638513 One 189 SGPP1_1 0.0000025587 0.020929857770881414 2.0298643448524998e-06 0.020929858 One 190 CD59_1 0.0000068828 0.021559533703573927 0.001648922456290617 0.021559534 One 191 MRPS21_5 0.0077373847 0.021700322664243165 9.63985905023122e-07 0.021700323 One 192 ILF2_1 0.0000000252 0.02183529105408133 3.091305085273976e-06 0.021835291 One 193 NRM_1 0.0002687490 0.022253050272657 2.0382718096255757e-09 0.02225305 One 194 FEM1C_1 0.0000014517 0.02227664632042583 8.589759094000804e-06 0.022276646 One 195 PRCP_1 0.0000000056 0.0230304550081597 2.1961723373343916e-07 0.023030455 One 196 P4HB_1 0.0000003568 0.02341318363108619 2.8084943956360846e-10 0.023413184 One 197 CD44_1 0.0000359903 0.023548564177701903 1.6066512112185574e-09 0.023548564 One 198 DCTN4_1 0.0013385549 0.024489122777067992 0.019368696851182407 0.024489123 One 199 YIPF5_1 0.0000060349 0.026730236331654417 1.0541687156357308e-06 0.026730236 One 200 AGPAT2_1 0.0000002107 0.026889530537036167 1.7713923094852022e-07 0.026889531 One 201 FAM136A_1 0.0006422807 0.028051819441664617 0.002488725830315593 0.028051819 One 202 TSPAN32_5 0.0000000000 0.02866197022141713 5.259717320638688e-06 0.02866197 One 203 PLA2G16_1 0.0003081786 0.02897405027367459 2.0665812391610075e-06 0.02897405 One 204 MET_2 0.0000285645 0.030192710022355414 0.00379589859681431 0.03019271 One 205 TMEM97_1 0.0036145788 0.03026262122509119 0.00021306559827421171 0.030262621 One 206 ZNF839_1 0.0000001711 0.030726289078901264 1.5879232684994666e-05 0.030726289 One 207 ERMAP_4 0.0001168108 0.031146240127524386 6.298967979200791e-05 0.03114624 One 208 TMEM150A_1 0.0000043452 0.03197682912178042 1.628398621899164e-05 0.031976829 One 209 PDIA5_1 0.0000034458 0.03351303270628667 2.3191823260124111e-10 0.033513033 One 210 CLIP1_3 0.0000001166 0.03429726403676071 4.469910794620894e-06 0.034297264 One 211 NUDT2_1 0.0000159662 0.034635799638304134 1.3986302087232156e-05 0.0346358 One 212 SMYD2_1 0.0000077856 0.03730228706011286 1.2971961011563423e-05 0.037302287 One 213 TMPO_1 0.0000008966 0.03798708635473315 9.272936461577683e-05 0.037987086 One 214 ZC4H2_5 0.0000000001 0.03821396773041524 3.364502202047952e-05 0.038213968 One 215 TXLNB_1 0.0063084330 0.038858943917955066 3.4406524050829844e-08 0.038858944 One 216 CHID1_3 0.0000000038 0.038921368031173256 1.7696631517095603e-08 0.038921368 One 217 TBXAS1_2 0.0001000498 0.03912053365002339 0.00017683963886805498 0.039120534 One 218 KLHL25_5 0.0000000143 0.04196676056691442 1.7560089108082686e-05 0.041966761 One 219 CSF3R_5 0.0000000304 0.04250513375736285 0.00017631047010437925 0.042505134 One 220 SEPHS1_1 0.0000222248 0.0450636464624055 6.469551154776827e-06 0.045063646 One 221 TRAT1_3 0.0000000000 0.04551857731992099 0.00013370660602496452 0.045518577 One 222 BET1_1 0.0000000254 0.0465608957106569 1.9024554960722768e-07 0.046560896 One 223 ZNF238_1 0.0000006050 0.046847268071909955 7.35354402710928e-05 0.046847268 One 224 BST1_1 0.0000370830 0.04931613832873068 0.0025410513361841546 0.049316138 One 225 CITED4_1 0.0000331218 0.04931613832873068 5.1719881815858375e-05 0.049316138 One

Table 4 lists the FRHs associated with the female cancer drug, and the markers defining the female cancer drugs and the FRHs associated therewith.

In addition, [Table 5] summarizes the results of calculating the degree of reactivity (P-value) of FRHs shown in [Table 4].

In these tables, FRH is expressed in the form of "FRH name_number of included markers", and "Var_Exp (pval)" means the correlation (Pvlaue) value of each marker on the corresponding gene expression, and "Var_Drug (pval)" Means the correlation (Pvlaue) value of the corresponding marker on the reactivity of the drug, and according to the order of drugs listed in [Table 4], the reactivity correlation value for each drug is divided by the classification factor 『/』 `` Exp_Drug (pval) '', and the correlation (Pvlaue) value of the gene expression corresponding to drug reactivity is arranged according to the order of drugs listed in [Table 4], and "Ave_VarDrug (pval)" is "Var_Drug ( pval) 』means the average value of the calculated values, and『 Rank 』means the number of female cancer drugs that the FRH significantly affects.

From these reactivity verification results, the lower the Var_Exp (pval), the lower the Var_Drug (pval) and its average value, Ave_VarDrug (pval), the lower the Exp_Drug (pval), the higher the Rank number, the corresponding marker determines drug reactivity It can be judged that the effectiveness is high as a biomarker.

Meanwhile, in FIG. 27, correlation values (P-vlaue) values of female biomarkers among major biomarkers among the biomarkers shown in Table 4 are graphically displayed, and in FIG. 28, genes expressed by major biomarkers P-vlaue values for female and female cancer drugs are shown graphically.

Reactive biomarkers for female and ovary drugs No. FRH Drug DrugType Var (marker) One IRX5_3 1526_RDEA119 (rescreen) / 1242_ (5Z) -7-Oxozeaenol / 1372_Trametinib / 1498_AZD6244 / 1014_RDEA119 / 1378_Bleomycin (50uM) / 1005_Cisplatin / 1019_Bosutinib / 165_DMOG / 1015_CI-1040 / 1053 1006_Cytarabine / 1060_PD-0325901 / 1013_Nilotinib / 1018_ABT-888 / 1268_XAV 939 / 1003_Camptothecin / 262_VX-11e / 1037_BX-795 / 1024_CEP-701 / 1017_Olaparib / 1043_ / 308_XL-880 / 1264_SGC0946 / 1494_SN-38 erk_mapk / other / erk_mapk / erk_mapk / erk_mapk / DNArep / DNArep / abl / other / erk_mapk / other / erk_mapk / abl / erk_mapk / g_integrity / DNArep / erk_mapk / abl / g_integrity / wnt / DNAmap / otherrep other / g_integrity / DNArep / jnk_p38 / mitosis / pi3k / igfr / rtk / chromatin / DNArep 1_13248174_T_C / 16_85071785_A_G / 9_34371054_A_C 2 IRX5_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 155_Ponatinib_2 / 1378_Bleomycin (50uM) _1 / 165_DMOG_3 / 1014_Refametinib_2 / 1242_ (5Z) -7-Oxozeaenol_3 / 159_HG6--1 erk_mapk / erk_mapk / erk_mapk / abl / DNArep / other / erk_mapk / other / erk_mapk 1_13248174_T_C 3 CMIP_1 1526_Refametinib_3 / 1015_CI-1040_2 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 1378_Bleomycin (50uM) _1 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / DNArep 16_85071785_A_G 4 PREX1_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 155_Ponatinib_2 / 1015_CI-1040_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / abl / erk_mapk 9_34371054_A_C 5 HIST1H2BK_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk 6_132814681_A_G 6 SERPINE1_2 1498_Selumetinib_2 / 1526_Refametinib_3 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk 1_17240836_G_T / X_156025548_C_T 7 SGTB_1 1242_ (5Z) -7-Oxozeaenol_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 other / erk_mapk / erk_mapk 9_74785802_T_C 8 XYLT2_1 1022_AZD7762_2 / 1378_Bleomycin (50uM) _1 g_integrity / DNArep 2_206056727_G_A 9 SOGA2_1 155_Ponatinib_2 / 1378_Bleomycin (50uM) _1 abl / DNArep 3_51980957_A_C 10 ZC3H12C_1 1378_Bleomycin (50uM) _1 / 1014_Refametinib_2 DNArep / erk_mapk 20_18452633_T_G 11 AFAP1L2_1 1526_Refametinib_3 / 1014_Refametinib_2 erk_mapk / erk_mapk 2_39717176_T_G 12 CHRNA5_1 134_Etoposide_1 / 295_NVP-BHG712_3 DNArep / rtk 3_196708735_G_GA 13 ASGR2_1 1024_Lestauritinib_2 / 1014_Refametinib_2 rtk / erk_mapk 10_38696926_C_T 14 RHBDL2_5 1114_Cetuximab_1 egfr 15_40896089_A_G / 15_40900360_T_C / 5_150068208_G_A / 10_132859105_C_T / 10_132860307_C_T 15 TMEM206_3 252_WZ3105_3 other 2_108378352_C_G / 14_106335417_A_C / 14_106360128_A_C 16 SUPT4H1_1 1022_AZD7762_2 g_integrity 11_114444466_A_G 17 LRTOMT_1 1022_AZD7762_2 g_integrity 19_10162649_G_A 18 EME2_1 1378_Bleomycin (50uM) _1 DNArep 7_108180467_G_T 19 TMEM158_1 1241_CHIR-99021_3 wnt 17_60211179_G_A 20 EFS_1 1242_ (5Z) -7-Oxozeaenol_3 other 19_30444797_C_A 21 CA5B_1 1378_Bleomycin (50uM) _1 DNArep 9_133696445_G_T 22 SDC1_1 1032_Afatinib_1 egfr 14_70246869_T_G 23 QSER1_1 226_GSK1070916_2 mitosis 13_79521022_A_T 24 GALNTL5_2 1012_Vorinostat_1 chromatin 15_34255437_A_T / 10_100352318_A_G 25 JAG1_5 1378_Bleomycin (50uM) _1 DNArep 3_122558313_G_T / 3_122558325_G_A / 3_122552357_T_TA / 3_122461164_C_G / 8_138636921_T_C 26 SOAT1_1 1022_AZD7762_2 g_integrity 7_108180467_G_T 27 BIRC2_1 231_FMK_3 erk_mapk 11_8101385_C_A 28 NAALADL2_1 1019_Bosutinib_1 abl 1_78893077_T_G 29 RGS2_1 1372_Trametinib_1 erk_mapk 18_12978734_C_G 30 PRR12_1 326_GSK690693_3 pi3k 6_38813973_C_T 31 AXL_2 1006_Cytarabine_1 DNArep 17_60211184_A_G / 5_224282_A_G 32 C6orf203_3 193_GW-2580_3 rtk 2_135390832_A_T / 17_48076840_A_G / 2_135230616_G_A 33 RNF208_2 255_CP724714_2 egfr 19_11832898_G_A / 4_7815971_GT_G 34 TNFRSF21_1 155_Ponatinib_2 abl 20_8802237_G_A 35 MAP6_1 29_AZ628_3 erk_mapk 7_6149477_GA_G 36 ABLIM1_1 1020_Lenalidomide_1 / 1017_Olaparib_2 / 1016_Temsirolimus_1 / 1170_CCT-018159_3 / 1004_Vinblastine_1 / 1033_Vismodegib_2 other / g_integrity / tor / other / cytoskeleton / other 4_70158293_T_TACAA 37 DIAPH1_5 1069_EHT-1864_3 / 222_BX-912_3 cytoskeleton / pi3k 7_73180651_C_T / 7_75212025_G_A / 7_74734035_C_T / 13_31758155_C_G / 7_72961358_G_A 38 FBXO10_5 222_BX-912_3 / 1008_Methotrexate_1 pi3k / DNArep 7_73180651_C_T / 7_75212025_G_A / 17_63918839_T_A / 7_72961358_G_A / 7_75403732_C_T 39 OLR1_1 1218_JQ1_3 chromatin 22_39017940_A_C 40 ADK_1 1001_AICA_Ribonucleotide_2 metabol 3_57269656_A_G 41 ETS1_5 1054_Palbociclib_2 cell_cyc 5_139680901_G_A / 5_150375777_G_T / 5_150393369_C_T / 9_41040359_C_T / 9_41938485_A_G 42 MDM2_4 1047_Nutlin-3a (-) _ 2 p53 8_89769704_A_C / 8_89786745_A_T / 8_89786749_T_TC / 8_89790263_A_G 43 NECAP1_1 1264_SGC0946_3 chromatin 11_92883335_A_C 44 PDZD8_1 194_Luminespib_2 other 2_120289468_AT_A 45 IFT46_1 1149_TW_37_3 apop 16_88608786_A_G 46 PLEKHA1_1 1032_Afatinib_1 egfr 16_89546571_ACC_AC 47 PTPN12_1 1006_Cytarabine_1 DNArep 7_63297679_T_C 48 CRH_1 277_Linifanib_2 rtk 2_208165676_C_T 49 UBE3B_1 301_PHA-793887_3 cell_cyc 1_3729650_T_C

Results of verification of biomarker responsiveness to female cancer drugs No. FRH Var_Exp (pval) Var_Drug (pval) Exp_Drug (pval) Ave_VarDrug (pval) Rank One IRX5_3 3.24E-08 2.09E-07 / 3.36E-07 / 1.23E-06 / 3.42E-06 / 5.09E-06 / 1.67E-05 / 7.91E-05 / 9.90E-05 / 0.000147359 / 0.000178145 / 0.000262223 / 0.000293231 / 0.000294131 / 0.000331406 / 0.000346165 / 0.000948858 / 0.002531744 / 0.002544254 / 0.002864291 / 0.003760149 / 0.004676935 / 0.004858024 / 0.005464656 / 0.005509754 / 0.005666416 / 0.005771071 / 0.006260361 / 0.006581211 / 0.006918188 / 0.007120129 / 0.00796253 / 0.008656866 / 0.00957777 4.01E-09 / 2.44E-07 / 2.68E-10 / 4.32E-09 / 3.38E-07 / 2.17E-07 / 0.00038571 / 0.000925853 / 7.73E-07 / 0.000383325 / 0.166450357 / 4.98E-06 / 3.01E -07 / 0.002000118 / 0.000442004 / 5.99E-05 / 0.000267605 / 0.213034545 / 0.159498838 / 0.00525218 / 0.00102741 / 0.020521632 / 0.009232963 / 0.002752168 / 0.238349359 / 0.011791795 / 0.003679783 / 0.012982528 / 0.023648082 / 0.203584523 / 4.71E-0659 0.049 / 0.000738179 3.40E-03 35 2 IRX5_1 0.0000015986 0.0007150123535033939 / 0.0003369412837112573 / 0.00032406884840248645 / 0.03648245720851939 / 0.0011099296303187667 / 0.006369243766371333 / 0.0005814803877258011 / 2.2678944506803809e-07 / 0.03733962059148955 4.012472503651177e-09 / 2.6827328582081137e-10 / 4.315496540370196e-09 / 3.0113839929611485e-07 / 2.1676383298007365e-07 / 7.7324514359278e-07 / 3.3835336443110047e-07 / 2.4825768930569727e-07 / 4.858619088818164e-06 0.009251 9 3 CMIP_1 0.0000003363 0.00011611305549562358 / 0.0012463700637828415 / 0.0030883823789405102 / 0.0016967292437561562 / 0.009832494532448445 / 0.002480457099824004 1.6131899966597346e-09 / 6.919962939545994e-07 / 2.849790178430554e-07 / 2.9927531009991034e-06 / 1.2590036500767103e-06 / 2.2920451294642218e-05 0.003077 6 4 PREX1_1 0.0000031534 0.01213588709116456 / 0.0008861989870959789 / 0.003387644664627276 / 0.005046821727923961 / 0.003659189631662927 / 0.0025267752687901323 2.0425679890502906e-07 / 7.604358543728916e-08 / 1.5529027829933754e-06 / 8.474366468515741e-07 / 4.250842448563364e-06 / 0.00011933684147066083 0.004607 6 5 HIST1H2BK_1 0.0000012706 2.0249380516365964e-05 / 0.00145858467735631 / 0.00010968434987171273 1.2231056098636564e-07 / 5.613023240161599e-07 / 1.606715671371094e-06 0.00053 3 6 SERPINE1_2 0.0000002953 0.0003204627533032064 / 0.00024487596208109635 / 0.0018306053201144902 2.270680653678334e-11 / 2.0037545467736346e-09 / 1.775004443361545e-08 0.000799 3 7 SGTB_1 0.0000081282 0.03228197565235906 / 0.005309250379800075 / 0.014353588850730884 7.002520053010446e-07 / 5.734586888069177e-07 / 3.864698922480986e-05 0.017315 3 8 XYLT2_1 0.0000020721 0.001833777815813712 / 0.0011629202987970622 0.000260290223137108 / 2.671958043521113e-05 0.001498 2 9 SOGA2_1 0.0000002061 0.0023870087560347447 / 0.0009469777545024177 4.478657034092263e-06 / 1.4354947060633677e-06 0.001667 2 10 ZC3H12C_1 0.0000026717 0.00215309882934333 / 0.017221760779553733 4.767376309274578e-08 / 6.661607188017109e-09 0.009687 2 11 AFAP1L2_1 0.0000003807 0.004214389226040113 / 0.02332396009307528 5.907987029847344e-06 / 2.4672683509692957e-05 0.013769 2 12 CHRNA5_1 0.0000508839 0.006701963959523267 / 0.036047880162305805 1.9077675767419626e-05 / 0.0006068009313248781 0.021375 2 13 ASGR2_1 0.0000011382 0.02920277002386234 / 0.016061730805368494 3.539163247328943e-06 / 6.152399665513134e-06 0.022632 2 14 RHBDL2_5 0.0000019238 7.1199917547458675e-06 0.0003696677024808176 7.12E-06 One 15 TMEM206_3 0.0000000202 0.00010519155045059184 5.5593739090589024e-05 0.000105 One 16 SUPT4H1_1 0.0000006972 0.00033848343004505154 6.5359378871259295e-06 0.000338 One 17 LRTOMT_1 0.0000018098 0.000559295705994161 1.3683390744827602e-05 0.000559 One 18 EME2_1 0.0000170380 0.0006898652477534458 2.7131355664636215e-07 0.00069 One 19 TMEM158_1 0.0000030678 0.0009840625910486822 1.609343995544786e-08 0.000984 One 20 EFS_1 0.0002217830 0.001122491007265465 1.5915921114557537e-06 0.001122 One 21 CA5B_1 0.0000190483 0.0014397265221401374 8.834878342812196e-06 0.00144 One 22 SDC1_1 0.0000871778 0.0021240823853264194 0.000582674749763457 0.002124 One 23 QSER1_1 0.0036525535 0.0037407673565606763 0.006866210754238516 0.003741 One 24 GALNTL5_2 0.0000004536 0.0038242994255904676 3.729288833430345e-05 0.003824 One 25 JAG1_5 0.0001089795 0.00636641270645681 1.7383815237379935e-05 0.006366 One 26 SOAT1_1 0.0000020782 0.006999312347871926 2.80467015954591e-08 0.006999 One 27 BIRC2_1 0.0000155207 0.00816300663512002 0.00018077138183493182 0.008163 One 28 NAALADL2_1 0.0000138905 0.008284426750211397 4.480439955191913e-07 0.008284 One 29 RGS2_1 0.0000013280 0.009860060162808696 1.7551881489443127e-06 0.00986 One 30 PRR12_1 0.0000069754 0.009867491010242535 1.7189797251912035e-05 0.009867 One 31 AXL_2 0.0000000105 0.014240994766530759 1.5079800937023606e-08 0.014241 One 32 C6orf203_3 0.0000002251 0.01855978051000038 0.008786487798916599 0.01856 One 33 RNF208_2 0.0000001032 0.030124190690403667 0.009683329859510285 0.030124 One 34 TNFRSF21_1 0.0000749035 0.03240280858096773 0.00031416021519650137 0.032403 One 35 MAP6_1 0.0000692014 0.03353292578624218 0.00013432237477471032 0.033533 One 36 ABLIM1_1 0.0000289457 8.551014437375636e-05 / 6.439870760609185e-05 / 0.0004942044619000223 / 0.0013462707233938519 / 0.0001769380795123695 / 0.00046864428768627844 6.495937674540172e-07 / 8.724045720306562e-07 / 4.458187235187017e-06 / 0.00014338311206655668 / 8.320751548561286e-05 / 8.117521266562836e-06 0.000439 6 37 DIAPH1_5 0.0000000343 0.0021569775481875115 / 0.009558471051782936 4.2351723063700285e-07 / 0.0007897012263719693 0.005858 2 38 FBXO10_5 0.0000511525 0.012717520661373393 / 0.011413820480670385 3.075936790924862e-05 / 5.483582287867406e-06 0.012066 2 39 OLR1_1 0.0000390604 0.00013538297001416112 0.0010150743709979484 0.000135 One 40 ADK_1 0.0000356335 0.0003915086428142265 8.510841943631868e-06 0.000392 One 41 ETS1_5 0.0000663161 0.00041860694731410804 7.897108946289616e-05 0.000419 One 42 MDM2_4 0.0000777136 0.00045220053022167466 1.1021957487827008e-06 0.000452 One 43 NECAP1_1 0.0000018931 0.006023068066858825 1.373445231848715e-05 0.006023 One 44 PDZD8_1 0.0000027222 0.011837688751336296 0.0006499029052944853 0.011838 One 45 IFT46_1 0.0000115713 0.016014639151541662 0.004518015024378813 0.016015 One 46 PLEKHA1_1 0.0011885939 0.01781962701682115 1.7283045033609196e-07 0.01782 One 47 PTPN12_1 0.0001114367 0.02274194948059581 1.024090488420046e-06 0.022742 One 48 CRH_1 0.0000029508 0.03250849770203413 0.0017907240115171536 0.032508 One 49 UBE3B_1 0.0000100508 0.048482309371415636 1.9954445445928623e-06 0.048482 One

Table 6 lists the FRHs associated with brain tumor drugs and the markers defining the brain tumor drugs and FRHs associated with them.

In addition, [Table 7] summarizes the results of calculating the degree of reactivity (P-value) of FRHs shown in [Table 6].

In these tables, FRH is expressed in the form of "FRH name_number of included markers", and "Var_Exp (pval)" means the correlation (Pvlaue) value of each marker on the corresponding gene expression, and "Var_Drug (pval)" Means the correlation (Pvlaue) value of the corresponding marker on the reactivity of the drug, and according to the order of drugs listed in [Table 6], the reactivity correlation value for each drug is divided into the classification factor 『/』 `` Exp_Drug (pval) '', the gene expression has a correlation (Pvlaue) value for drug responsiveness according to the order of drugs listed in [Table 6], and "Ave_VarDrug (pval)" is "Var_Drug ( pval) 』means the average value of the calculated values, and『 Rank 』means the number of brain tumor drugs that significantly affect the corresponding FRH.

From these reactivity verification results, the lower the Var_Exp (pval), the lower the Var_Drug (pval) and its average value, Ave_VarDrug (pval), the lower the Exp_Drug (pval), the higher the Rank number, the corresponding marker determines drug reactivity It can be judged that the effectiveness is high as a biomarker.

On the other hand, in FIG. 29, the correlation values (P-vlaue) values of brain biomarkers among major biomarkers among the biomarkers listed in Table 6 are graphically displayed, and in FIG. 30, genes expressed by the major biomarkers And P-vlaue values for brain tumor drugs are graphed.

Reactive biomarkers for brain tumor drugs No. FRH Drug DrugType Var (marker) One PTRF_9 9_MG-132 / 17_Cyclopamine / 34_Imatinib / 51_Dasatinib / 56_WH-4-023 / 94_TGX221 / 104_Bortezomib / 106_XMD8-85 / 147_NSC-87877 / 150_Bicalutamide / 151_QS11 / 156_AZD6482 / 159_HG-6-IP-1 178_BAY 61-3606 / 179_5-Fluorouracil / 184_BMS-754807 / 185_OSI-906 / 186_Bexarotene / 196_Phenformin / 199_Pazopanib / 200_LAQ824 / 211_TL-2-105 / 221_TAK-715 / 226_GSK1070916 / 228_KIN001 / 254 -II-72-1 / 263_FR-180204 / 265_Tubastatin A / 269_NSC-207895 / 272_AR-42 / 275_I-BET-762 / 276_CAY10603 / 281_CH5424802 / 288_KIN001-055 / 290_KIN001-260 / 291_KIN001-266 / 293_MP470-1- IN-1 / 300_CX-5461 / 304_SB52334 / 305_TPCA-1 / 310_YM201636 / 333_T0901317 / 344_THZ-2-49 / 345_KIN001-270 / 1007_Docetaxel / 1008_Methotrexate / 1011_ABT-263 / 1012_Vorinostat / 1016_Temsirolimus / 1016_Temsirolimus / 1016_Temsirolimus / 1016_Temsirolimus VIII / 1091_BMS-536924 / 1166_QL-VIII-58 / 1248_FK866 / 1261_r TRAIL / 1262_UNC1215 / 1264_SGC0946 / 1526_RDEA119 (rescreen) / 1527_GDC0941 (rescreen) other / other / abl / abl / abl / pi3k / other / other / other / other / other / pi3k / erk_mapk / apop / cytoskeleton / other / DNArep / igfr / igfr / other / metabol / rtk / chromatin / erk_mapk / jnk_p38 / mitosis / pi3k / rtk / rtk / egfr / mitosis / erk_mapk / chromatin / p53 / chromatin / chromatin / chromatin / rtk / other / other / other / rtk / mitosis / other / rtk / other / other / other / cell_cyc / cell_cyc / cytoskeleton / DNArep / apop / chromatin / tor / other / rtk / other / jnk_p38 / igfr / tor / metabol / apop / other / chromatin / erk_mapk / pi3k 11_12162199_T_G / 13_113159942_A_G / 5_181155466_T_G / 11_65547388_T_G / 10_11921140_T_G / 17_55774876_T_G / 12_40313960_G_T / 16_1817242_T_C / 2_113934259_C_T 2 MBTD1_5 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 226_GSK1070916_2 / 179_5-Fluorouracil_1 / 221_TAK-715_2 / 257_NPK76-II-72-1_3 / 275_I-BET-762_3 / 260 300_CX-5461_3 / 265_Tubastatin A_3 / 185_Linsitinib_2 / 253_XMD14-99_3 other / mitosis / rtk / chromatin / mitosis / DNArep / jnk_p38 / mitosis / chromatin / chromatin / apop / p53 / rtk / other / chromatin / igfr / rtk 17_55774876_T_G / 15_65451964_A_G / 2_113934259_C_T / 12_57062993_T_G / 11_65547388_T_G 3 C12orf29_4 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 263_FR-180204_3 / 305_TPCA-1_3 / 275_I-BET-762_3 / 272_AR-42_2 / 310_YM201636_3 / 1012_Vorinostat_1 / 276_CAY10603_3 / 184_BMS-754807_2 mitosis / igfr / erk_mapk / other / chromatin / chromatin / other / chromatin / chromatin / igfr 12_40313960_G_T / 4_173528913_A_G / 15_65451964_A_G / 10_79312556_A_G 4 DDX20_1 294_MPS-1-IN-1_3 / 265_Tubastatin A_3 / 305_TPCA-1_3 / 300_CX-5461_3 / 257_NPK76-II-72-1_3 / 179_5-Fluorouracil_1 / 290_KIN001-260_3 / 276_CAY10603_3 / 1012_Vorinostat_1 / 270 mitosis / chromatin / other / other / mitosis / DNArep / other / chromatin / chromatin / cell_cyc 8_30756677_T_G 5 TACC1_4 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 221_TAK-715_2 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 253_XMD14-99_3 / 300_CX-5461_ chromatin / mitosis / rtk / jnk_p38 / DNArep / other / rtk / erk_mapk / rtk / other 11_12162199_T_G / 12_51745916_T_G / 16_15664675_G_T / 16_55415_T_G 6 SFPQ_1 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 290_KIN001-260_3 / 179_5-Fluorouracil_1 / 309_Y-39983_3 / 265_Tubastatin A_3 / 275_I-BET-762_3180_263 chromatin / other / mitosis / other / other / DNArep / cytoskeleton / chromatin / chromatin / erk_mapk 8_30756677_T_G 7 LRPPRC_2 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 1091_BMS-536924_3 / 253_XMD14-99_3 / 293_Amuvatinib_2 / 184_BMS-754807_2 / 257_NPK76II mitosis / other / rtk / igfr / chromatin / igfr / rtk / rtk / igfr / mitosis 12_40313960_G_T / 11_12162199_T_G 8 ILF3_5 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 1011_Navitoclax_2 / 263_FR-180204_3 / 288_WHI-P97_3 / 257_NPK76-II-72-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / other / chromatin / apop / erk_mapk / other / mitosis / DNArep / rtk 5_181155466_T_G / 2_113934259_C_T / 11_12162199_T_G / 12_6818898_A_C / 15_65451964_A_G 9 ATXN7L3B_5 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 257_NPK76-II-72-1_3 / 269_NSC-207895_3 / 185_Linsitinib_2 / 226_GSK1070916_2 / 184_BMS-754807_2 other / mitosis / chromatin / rtk / mitosis / p53 / igfr / mitosis / igfr 2_113934259_C_T / 5_181155466_T_G / 15_65451964_A_G / 2_108507561_T_G / 12_57062993_T_G 10 CENPV_1 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 300_CX-5461_3 / 305_TPCA-1_3 / 304_SB52334_3 / 1011_Navitoclax_2 / 185_Linsitinib_2 DNArep / chromatin / rtk / mitosis / other / other / rtk / apop / igfr 5_181155466_T_G 11 CAMKV_4 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 281_Alectinib_2 / 1012_Vorinostat_1 / 263_FR-180204_3 / 253_XMD14-99_3 mitosis / DNArep / other / other / rtk / chromatin / erk_mapk / rtk 13_113159942_A_G / 16_1817242_T_C / 3_128945112_G_A / 20_42084724_T_C 12 TPMT_3 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 1091_BMS-536924_3 / 185_Linsitinib_2 / 226_GSK1070916_2 rtk / mitosis / chromatin / rtk / DNArep / igfr / igfr / mitosis 9_37887606_C_T / 2_61492168_C_A / 11_12162199_T_G 13 WASF1_3 305_TPCA-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 300_CX-5461_3 / 269_NSC-207895_3 / 185_Linsitinib_2 other / chromatin / DNArep / mitosis / rtk / other / p53 / igfr 16_55415_T_G / 10_43200831_A_G / 2_108507561_T_G 14 DDX25_4 263_FR-180204_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 293_Amuvatinib_2 / 255_CP724714_2 / 300_CX-5461_3 / 179_5-Fluorouracil_1 erk_mapk / chromatin / mitosis / other / rtk / egfr / other / DNArep 2_61492168_C_A / 5_181155466_T_G / 11_43920052_A_C / 12_40313960_G_T 15 ACVR2B_5 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 265_Tubastatin A_3 / 1011_Navitoclax_2 / 263_FR-180204_3 DNArep / mitosis / rtk / chromatin / other / chromatin / apop / erk_mapk 16_1817242_T_C / 10_11921140_T_G / 13_113159942_A_G / 20_42084724_T_C / 11_34452090_T_G 16 TAP1_4 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 185_Linsitinib_2 / 1011_Navitoclax_2 / 304_SB52334_3 / 305_TPCA-1_3 / 275_I-BET-762_3 mitosis / DNArep / chromatin / igfr / apop / rtk / other / chromatin 11_12162199_T_G / 10_11921140_T_G / 5_181155466_T_G / 20_42084724_T_C 17 SMPD1_1 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 / 221_TAK-715_2 / 1011_Navitoclax_2 / 265_Tubastatin A_3 chromatin / DNArep / other / other / mitosis / jnk_p38 / apop / chromatin 16_87644643_G_A 18 PEA15_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 293_Amuvatinib_2 / 226_GSK1070916_2 / 305_TPCA-1_3 / 221_TAK-715_2 / 263_FR-180204_3 chromatin / mitosis / rtk / rtk / mitosis / other / jnk_p38 / erk_mapk 5_181155466_T_G / 10_50311228_T_G / 11_12162199_T_G / 22_18345007_A_C / 2_60761746_T_G 19 SLC25A43_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 263_FR-180204_3 / 253_XMD14-99_3 / 179_5-Fluorouracil_1 mitosis / other / rtk / igfr / chromatin / erk_mapk / rtk / DNArep 1_54243266_A_G 20 MT2A_5 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 275_I-BET-762_3 / 304_SB52334_3 / 185_Linsitinib_2 mitosis / DNArep / other / mitosis / chromatin / rtk / igfr 13_113159942_A_G / 22_42212334_A_C / 10_11921140_T_G / 15_75524142_T_C / X_100585180_G_T 21 RUNX1_2 196_Phenformin_3 / 344_THZ-2-49_3 / 156_AZD6482_2 / 94_TGX221_3 / 1166_QL-VIII-58_3 / 51_Dasatinib_1 / 1007_Docetaxel_1 metabol / cell_cyc / pi3k / pi3k / tor / abl / cytoskeleton 1_78629896_T_C / 8_7290003_A_C 22 LRRC8B_3 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 263_FR-180204_3 / 276_CAY10603_3 mitosis / rtk / other / DNArep / other / erk_mapk / chromatin 12_40313960_G_T / 11_12162199_T_G / 17_55774876_T_G 23 PSMB9_4 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 275_I-BET-762_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 185_Linsitinib_2 mitosis / rtk / DNArep / chromatin / other / chromatin / igfr 11_12162199_T_G / 10_11921140_T_G / 16_55415_T_G / X_2856636_A_C 24 RRAS_5 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 269_NSC-207895_3 / 304_SB52334_3 mitosis / DNArep / other / apop / other / p53 / rtk 11_12162199_T_G / 2_113934259_C_T / 16_18379704_T_G / 13_113159942_A_G / 17_55774876_T_G 25 TMBIM1_5 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 185_Linsitinib_2 mitosis / DNArep / rtk / other / chromatin / other / igfr 17_51169925_C_T / 1_228244520_T_G / 1_213007133_T_G / 16_55415_T_G / 5_38950065_A_T 26 KLHL23_3 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 263_FR-180204_3 / 1011_Navitoclax_2 / 300_CX-5461_3 / 1012_Vorinostat_1 mitosis / DNArep / rtk / erk_mapk / apop / other / chromatin 13_113159942_A_G / 10_79312556_A_G / 13_113325635_A_G 27 EWSR1_1 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 288_WHI-P97_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 310_YM201636_3 mitosis / apop / other / other / DNArep / chromatin / other 20_42084724_T_C 28 ZNF124_3 1012_Vorinostat_1 / 1011_Navitoclax_2 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 300_CX-5461_3 / 179_5-Fluorouracil_1 chromatin / apop / rtk / mitosis / other / other / DNArep 13_113159942_A_G / 2_170965958_A_C / 17_55774876_T_G 29 CAPG_2 1026_Tanespimycin_2 / 344_THZ-2-49_3 / 196_Phenformin_3 / 1527_Pictilisib_2 / 17_Cyclopamine_3 / 94_TGX221_3 / 1007_Docetaxel_1 other / cell_cyc / metabol / pi3k / other / pi3k / cytoskeleton 7_72942379_A_C / 15_56464990_A_C 30 TGOLN2_2 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 304_SB52334_3 / 300_CX-5461_3 chromatin / DNArep / mitosis / other / erk_mapk / rtk / other 19_7740447_T_G / 19_11402175_A_C 31 RBFOX1_1 294_MPS-1-IN-1_3 / 304_SB52334_3 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 281_Alectinib_2 / 305_TPCA-1_3 / 253_XMD14-99_3 mitosis / rtk / other / DNArep / rtk / other / rtk 1_213007133_T_G 32 RANBP2_2 305_TPCA-1_3 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 269_NSC-207895_3 / 257_NPK76-II-72-1_3 other / rtk / mitosis / DNArep / other / p53 / mitosis 11_65547388_T_G / 15_55329691_T_C 33 CCT2_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 269_NSC-207895_3 / 272_AR-42_2 / 185_Linsitinib_2 mitosis / other / chromatin / erk_mapk / p53 / chromatin / igfr 12_40313960_G_T 34 CEP95_2 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 / 304_SB52334_3 / 253_XMD14-99_3 / 281_Alectinib_2 / 1012_Vorinostat_1 DNArep / mitosis / mitosis / rtk / rtk / rtk / chromatin 17_55774876_T_G / 11_12162199_T_G 35 GINM1_3 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 184_BMS-754807_2 / 1091_BMS-536924_3 mitosis / erk_mapk / rtk / igfr / chromatin / igfr / igfr 11_12162199_T_G / 4_154328181_A_C / 10_73803641_A_G 36 POLG2_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 221_TAK-715_2 / 304_SB52334_3 / 1091_BMS-536924_3 / 281_Alectinib_2 / 253_XMD14-99_3 chromatin / mitosis / jnk_p38 / rtk / igfr / rtk / rtk 22_22098988_G_T / 19_4911043_A_C 37 RAN_2 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 1012_Vorinostat_1 / 263_FR-180204_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 281_Alectinib_2 mitosis / apop / chromatin / erk_mapk / other / DNArep / rtk 19_3281403_A_C / 10_11921140_T_G 38 MTF2_2 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 265_Tubastatin A_3 / 257_NPK76-II-72-1_3 / 269_NSC-207895_3 / 304_SB52334_3 other / mitosis / DNArep / chromatin / mitosis / p53 / rtk 5_181155466_T_G / 6_30705792_T_G 39 CMPK1_1 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 184_BMS-754807_2 / 1012_Vorinostat_1 / 293_Amuvatinib_2 / 253_XMD14-99_3 / 304_SB52334_3 igfr / mitosis / igfr / chromatin / rtk / rtk / rtk 16_18379704_T_G 40 MDN1_1 1012_Vorinostat_1 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 276_CAY10603_3 / 305_TPCA-1_3 / 269_NSC-207895_3 chromatin / apop / DNArep / mitosis / chromatin / other / p53 11_65547388_T_G 41 INPP1_2 265_Tubastatin A_3 / 276_CAY10603_3 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 310_YM201636_3 chromatin / chromatin / other / mitosis / DNArep / other 14_78966462_C_T / 16_55415_T_G 42 TOMM20_5 1012_Vorinostat_1 / 253_XMD14-99_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 300_CX-5461_3 chromatin / rtk / DNArep / mitosis / rtk / other 10_11921140_T_G / 20_42084724_T_C / 2_61492168_C_A / 17_55774876_T_G / 16_18379704_T_G 43 S100A6_3 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 305_TPCA-1_3 chromatin / mitosis / rtk / DNArep / apop / other 10_11921140_T_G / 7_159142364_T_G / 8_30756677_T_G 44 ZNF74_5 1012_Vorinostat_1 / 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 305_TPCA-1_3 / 304_SB52334_3 chromatin / igfr / mitosis / igfr / other / rtk 5_181155466_T_G / 17_55774876_T_G / 1_234373536_T_G / 2_113934259_C_T / 2_61492168_C_A 45 ZNF195_3 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 185_Linsitinib_2 / 226_GSK1070916_2 mitosis / other / rtk / erk_mapk / igfr / mitosis 12_40313960_G_T / 2_113934259_C_T / 12_51745916_T_G 46 DNMT3A_2 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 185_Linsitinib_2 / 263_FR-180204_3 / 1091_BMS-536924_3 mitosis / other / chromatin / igfr / erk_mapk / igfr 2_113934259_C_T / 11_12162199_T_G 47 PXDC1_3 294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 mitosis / rtk / other / igfr / DNArep / chromatin 13_113159942_A_G / 11_65547388_T_G / 7_159142364_T_G 48 HOXD8_1 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 185_Linsitinib_2 / 281_Alectinib_2 rtk / mitosis / rtk / erk_mapk / igfr / rtk 20_42084724_T_C 49 CREB3_5 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 253_XMD14-99_3 / 304_SB52334_3 mitosis / chromatin / other / DNArep / rtk / rtk 5_181155466_T_G / 1_54243266_A_G / 11_12162199_T_G / 6_30705792_T_G / 12_6818898_A_C 50 HDAC2_5 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 293_Amuvatinib_2 / 1012_Vorinostat_1 / 304_SB52334_3 apop / DNArep / other / rtk / chromatin / rtk 17_55774876_T_G / 11_65547388_T_G / 15_75524142_T_C / 14_55169342_TAAA_T / 15_55329691_T_C 51 TIMP1_5 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 253_XMD14-99_3 DNArep / other / other / mitosis / apop / rtk 16_1817242_T_C / 3_128945112_G_A / 5_181155466_T_G / 16_30398066_C_A / 11_34452090_T_G 52 COQ10B_2 305_TPCA-1_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 179_5-Fluorouracil_1 other / chromatin / mitosis / rtk / igfr / DNArep 13_113159942_A_G / 1_149852603_A_G 53 REEP5_3 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 257_NPK76-II-72-1_3 / 304_SB52334_3 mitosis / other / DNArep / other / mitosis / rtk 5_181155466_T_G / 16_87644643_G_A / 2_113934259_C_T 54 FAM111A_5 304_SB52334_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 1091_BMS-536924_3 rtk / mitosis / igfr / chromatin / other / igfr 2_108507561_T_G / 13_113159942_A_G / 10_11921140_T_G / 16_1817242_T_C / 1_213007133_T_G 55 XPO5_2 1012_Vorinostat_1 / 269_NSC-207895_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 276_CAY10603_3 / 294_MPS-1-IN-1_3 chromatin / p53 / other / mitosis / chromatin / mitosis 15_75524142_T_C / 11_65547388_T_G 56 MICALL2_2 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1 / 156_AZD6482_2 cell_cyc / metabol / pi3k / other / abl / pi3k 8_7290003_A_C / 7_72942379_A_C 57 ITGA3_1 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 288_WHI-P97_3 mitosis / chromatin / erk_mapk / other / DNArep / other 5_181155466_T_G 58 MATR3_5 304_SB52334_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 269_NSC-207895_3 / 1011_Navitoclax_2 rtk / other / mitosis / DNArep / p53 / apop 17_55774876_T_G / 10_73803531_T_C / 11_65547388_T_G / 12_7433515_G_T / 16_18379704_T_G 59 SAT1_1 294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 305_TPCA-1_3 / 185_Linsitinib_2 mitosis / rtk / chromatin / erk_mapk / other / igfr 12_40313960_G_T 60 TMED9_2 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 263_FR-180204_3 other / mitosis / rtk / igfr / chromatin / erk_mapk 13_113159942_A_G / 11_12162199_T_G 61 KIF26A_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 1091_BMS-536924_3 / 263_FR-180204_3 / 185_Linsitinib_2 chromatin / mitosis / rtk / igfr / erk_mapk / igfr 10_11921140_T_G / 7_159142364_T_G 62 C19orf66_2 294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 / 253_XMD14-99_3 / 293_Amuvatinib_2 / 310_YM201636_3 mitosis / rtk / other / rtk / rtk / other 16_87644643_G_A / X_2856636_A_C 63 GTF3C2_2 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 263_FR-180204_3 / 281_Alectinib_2 / 185_Linsitinib_2 mitosis / chromatin / rtk / erk_mapk / rtk / igfr 7_128839939_T_G / 7_159142364_T_G 64 ADAM9_5 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 185_Linsitinib_2 / 1011_Navitoclax_2 mitosis / rtk / DNArep / rtk / igfr / apop 11_12162199_T_G / 12_51745916_T_G / 10_11921140_T_G / 8_122952205_T_G / 5_181155466_T_G 65 KDM1A_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 176_IPA-3_3 / 179_5-Fluorouracil_1 / 276_CAY10603_3 mitosis / chromatin / other / cytoskeleton / DNArep / chromatin 1_26774532_T_C / 22_42212334_A_C / 5_181155466_T_G 66 SRSF1_1 1012_Vorinostat_1 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 / 179_5-Fluorouracil_1 / 281_Alectinib_2 chromatin / rtk / mitosis / mitosis / DNArep / rtk 16_87644643_G_A 67 WHAMM_1 1012_Vorinostat_1 / 305_TPCA-1_3 / 281_Alectinib_2 / 263_FR-180204_3 / 300_CX-5461_3 / 253_XMD14-99_3 chromatin / other / rtk / erk_mapk / other / rtk 2_113934259_C_T 68 LEPRE1_4 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 106_XMD8-85_3 / 156_AZD6482_2 cell_cyc / pi3k / other / metabol / other / pi3k 3_191357867_G_A / 16_72119226_C_G / 3_191358113_C_T / 16_72150667_C_T 69 TRMT61B_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 265_Tubastatin A_3 / 276_CAY10603_3 / 185_Linsitinib_2 mitosis / other / rtk / chromatin / chromatin / igfr 12_124473081_C_T 70 KANK1_1 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 185_Linsitinib_2 / 305_TPCA-1_3 / 253_XMD14-99_3 mitosis / rtk / igfr / igfr / other / rtk 11_12162199_T_G 71 FAM126A_1 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 156_AZD6482_2 / 51_Dasatinib_1 / 196_Phenformin_3 pi3k / cell_cyc / other / pi3k / abl / metabol 7_72942379_A_C 72 CASKIN1_1 1012_Vorinostat_1 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 chromatin / apop / DNArep / mitosis / rtk / igfr 10_11921140_T_G 73 PHIP_3 269_NSC-207895_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 257_NPK76-II-72-1_3 / 300_CX-5461_3 p53 / mitosis / other / DNArep / mitosis / other 15_55329691_T_C / 15_55340661_G_T / 12_40313960_G_T 74 ISL1_1 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 1011_Navitoclax_2 / 281_Alectinib_2 / 304_SB52334_3 mitosis / chromatin / erk_mapk / apop / rtk / rtk 11_12162199_T_G 75 FAM114A1_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 275_I-BET-762_3 / 300_CX-5461_3 mitosis / DNArep / chromatin / other / chromatin / other 12_51745916_T_G 76 BHLHE40_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 281_Alectinib_2 / 305_TPCA-1_3 / 1091_BMS-536924_3 chromatin / mitosis / erk_mapk / rtk / other / igfr 11_12162199_T_G / 6_30705792_T_G / 8_122952205_T_G / 14_93183653_A_C / 12_6941768_C_A 77 RNH1_2 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 269_NSC-207895_3 / 281_Alectinib_2 / 253_XMD14-99_3 mitosis / DNArep / other / p53 / rtk / rtk 16_1817242_T_C / 13_113159942_A_G 78 SLC35F5_2 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 1012_Vorinostat_1 / 300_CX-5461_3 mitosis / other / DNArep / rtk / chromatin / other 17_6118065_A_G / 13_113159942_A_G 79 TRAP1_1 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 293_Amuvatinib_2 / 263_FR-180204_3 / 1011_Navitoclax_2 chromatin / mitosis / other / rtk / erk_mapk / apop 9_69516199_A_C 80 SLC10A3_1 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 304_SB52334_3 DNArep / mitosis / chromatin / other / other / rtk 13_113159942_A_G 81 IL10RB_1 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 184_BMS-754807_2 / 263_FR-180204_3 igfr / mitosis / apop / other / igfr / erk_mapk 11_65547388_T_G 82 CCDC138_3 269_NSC-207895_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 257_NPK76-II-72-1_3 p53 / chromatin / other / DNArep / mitosis 15_75524142_T_C / 12_40313960_G_T / 8_30756677_T_G 83 LDLRAP1_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 304_SB52334_3 / 179_5-Fluorouracil_1 mitosis / other / igfr / rtk / DNArep 16_55415_T_G 84 SH3BGRL3_3 179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 / 304_SB52334_3 / 253_XMD14-99_3 DNArep / other / apop / rtk / rtk 17_55774876_T_G / 16_87644643_G_A / 5_181155466_T_G 85 RARRES3_3 294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 179_5-Fluorouracil_1 / 263_FR-180204_3 / 1012_Vorinostat_1 mitosis / chromatin / DNArep / erk_mapk / chromatin 12_40313960_G_T / 1_213007133_T_G / 16_87644643_G_A 86 ANXA4_4 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 293_Amuvatinib_2 mitosis / chromatin / rtk / DNArep / rtk 19_11402175_A_C / 6_33799054_A_G / 8_30756677_T_G / 8_27431326_A_G 87 LYST_1 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 293_Amuvatinib_2 / 310_YM201636_3 chromatin / other / mitosis / rtk / other 16_55415_T_G 88 MR1_4 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 1012_Vorinostat_1 mitosis / apop / DNArep / other / chromatin 1_234373536_T_G / 15_84241166_A_C / 10_79312556_A_G / 19_7740447_T_G 89 SELRC1_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 226_GSK1070916_2 / 253_XMD14-99_3 mitosis / other / chromatin / mitosis / rtk 12_40313960_G_T 90 LDHB_5 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2 chromatin / other / mitosis / DNArep / apop 12_40313960_G_T / 11_12162199_T_G / 11_65547388_T_G / 5_181155466_T_G / 4_108762737_T_G 91 GBE1_2 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 51_Dasatinib_1 cell_cyc / pi3k / other / metabol / abl 8_7290003_A_C / 7_72942379_A_C 92 PTRF_2 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1 cell_cyc / pi3k / metabol / other / abl 8_7290003_A_C / 7_72942379_A_C 93 SQSTM1_3 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 304_SB52334_3 / 179_5-Fluorouracil_1 mitosis / other / igfr / rtk / DNArep 1_26774532_T_C / 11_12162199_T_G / 13_39724512_C_T 94 PA2G4_1 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1011_Navitoclax_2 / 310_YM201636_3 chromatin / mitosis / other / apop / other 12_40313960_G_T 95 GBP3_2 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 1091_BMS-536924_3 / 305_TPCA-1_3 / 253_XMD14-99_3 mitosis / chromatin / igfr / other / rtk 15_75524142_T_C / 12_40313960_G_T 96 CHD7_2 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 275_I-BET-762_3 DNArep / mitosis / chromatin / other / chromatin 11_65547388_T_G / 12_40313960_G_T 97 ELF4_4 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1091_BMS-536924_3 / 304_SB52334_3 / 263_FR-180204_3 mitosis / igfr / igfr / rtk / erk_mapk 13_113159942_A_G / 8_28850143_T_G / 2_108507561_T_G / 16_30953637_A_C 98 HEXB_2 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 1012_Vorinostat_1 mitosis / rtk / DNArep / other / chromatin 11_65547388_T_G / 11_12162199_T_G 99 TGOLN2_3 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 156_AZD6482_2 cell_cyc / metabol / pi3k / other / pi3k 2_105307612_A_C / 7_72942379_A_C / 8_7290003_A_C 100 CBR3_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 276_CAY10603_3 chromatin / mitosis / DNArep / other / chromatin 8_30756677_T_G / 3_128945112_G_A / 12_6818898_A_C / 22_22098988_G_T / 2_60761746_T_G 101 C14orf93_1 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 185_Linsitinib_2 / 263_FR-180204_3 / 253_XMD14-99_3 chromatin / DNArep / igfr / erk_mapk / rtk 20_42084724_T_C 102 ACVR1B_5 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 281_Alectinib_2 apop / mitosis / igfr / chromatin / rtk 5_181155466_T_G / 11_12162199_T_G / 10_79312556_A_G / 2_113934259_C_T / 12_6818898_A_C 103 WNK2_1 1011_Navitoclax_2 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 294_MPS-1-IN-1_3 apop / chromatin / DNArep / rtk / mitosis 10_11921140_T_G 104 GBE1_5 1012_Vorinostat_1 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 chromatin / rtk / mitosis / DNArep / other 5_181155466_T_G / 16_58525116_G_T / 11_73355795_A_G / 10_11921140_T_G / 8_122952205_T_G 105 RAB27A_2 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 156_AZD6482_2 cell_cyc / metabol / pi3k / other / pi3k 8_7290003_A_C / 15_56464990_A_C 106 FAP_3 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 221_TAK-715_2 / 345_KIN001-270_3 mitosis / DNArep / chromatin / jnk_p38 / cell_cyc 17_55774876_T_G / 1_183963850_T_G / 11_94082585_T_C 107 THBS1_1 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1 cell_cyc / metabol / pi3k / other / abl 8_7290003_A_C 108 RNF44_2 1012_Vorinostat_1 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 221_TAK-715_2 / 305_TPCA-1_3 chromatin / igfr / DNArep / jnk_p38 / other 8_12430448_C_T / 10_11921140_T_G 109 C2orf44_4 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 igfr / mitosis / chromatin / other / DNArep 7_108023984_G_A / 7_108024001_C_T / 11_65547388_T_G / 14_55169342_TAAA_T 110 ZSCAN2_1 304_SB52334_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 226_GSK1070916_2 rtk / other / mitosis / igfr / mitosis 2_61492168_C_A 111 PSMB8_3 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 185_Linsitinib_2 / 275_I-BET-762_3 mitosis / rtk / DNArep / igfr / chromatin 11_12162199_T_G / X_2856636_A_C / 10_11921140_T_G 112 CTGF_2 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 mitosis / chromatin / rtk / igfr / DNArep 13_113159942_A_G / 2_188994726_T_G 113 DAP_1 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 185_Linsitinib_2 / 179_5-Fluorouracil_1 igfr / mitosis / chromatin / igfr / DNArep 12_51745916_T_G 114 PHOX2A_1 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 185_Linsitinib_2 / 1091_BMS-536924_3 mitosis / chromatin / DNArep / igfr / igfr 12_51745916_T_G 115 MVP_2 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 253_XMD14-99_3 mitosis / DNArep / chromatin / other / rtk 12_40313960_G_T / 11_68785018_G_A 116 CCNJ_2 304_SB52334_3 / 294_MPS-1-IN-1_3 / 293_Amuvatinib_2 / 305_TPCA-1_3 / 263_FR-180204_3 rtk / mitosis / rtk / other / erk_mapk 14_55169342_TAAA_T / 1_234373536_T_G 117 MAP4_5 294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 221_TAK-715_2 mitosis / rtk / other / chromatin / jnk_p38 16_81270082_T_G / 14_93183653_A_C / 1_54243266_A_G / 2_157299566_T_G / 16_58526137_A_C 118 ATP5B_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 305_TPCA-1_3 / 263_FR-180204_3 chromatin / mitosis / igfr / other / erk_mapk 1_54243266_A_G / 6_31966660_T_G 119 TRAM2_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 263_FR-180204_3 / 1091_BMS-536924_3 mitosis / chromatin / rtk / erk_mapk / igfr 11_12162199_T_G / 13_113159942_A_G / 12_40313960_G_T 120 CCDC107_5 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 263_FR-180204_3 chromatin / other / mitosis / other / erk_mapk 17_19414393_T_G / 11_1242476_T_G / 16_259458_T_G / 1_54243266_A_G / 1_171541102_T_G 121 SMARCAD1_5 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 185_Linsitinib_2 mitosis / other / rtk / igfr / igfr 12_40313960_G_T / 15_65451964_A_G / 11_65547388_T_G / 6_30705792_T_G / 17_55774876_T_G 122 HRH1_1 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 263_FR-180204_3 mitosis / igfr / chromatin / DNArep / erk_mapk 9_108900415_C_A 123 KHDRBS1_2 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 257_NPK76-II-72-1_3 chromatin / other / mitosis / igfr / mitosis 5_181155466_T_G / 12_6818898_A_C 124 E2F6_3 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 184_BMS-754807_2 / 305_TPCA-1_3 igfr / mitosis / erk_mapk / igfr / other 1_248122139_G_T / 1_248122185_A_G / 12_109800676_G_A 125 ELL2_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 1091_BMS-536924_3 / 305_TPCA-1_3 chromatin / mitosis / erk_mapk / igfr / other 10_73803531_T_C / 5_181155466_T_G 126 BSN_2 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 281_Alectinib_2 mitosis / igfr / other / DNArep / rtk 16_1817242_T_C / 13_113159942_A_G 127 ATG4A_5 1012_Vorinostat_1 / 305_TPCA-1_3 / 253_XMD14-99_3 / 226_GSK1070916_2 chromatin / other / rtk / mitosis 2_61492168_C_A / 2_113934259_C_T / 9_108900415_C_A / 16_87644643_G_A / 9_35398502_T_G 128 CD44_4 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 chromatin / other / mitosis / igfr 12_40313960_G_T / 15_75524142_T_C / 12_51745916_T_G / 2_113934259_C_T 129 GSN_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 chromatin / mitosis / apop / DNArep 10_11921140_T_G / 13_113159942_A_G / 5_181155466_T_G / 16_1817242_T_C / 15_75524142_T_C 130 CD99_5 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / apop / DNArep / rtk 16_1817242_T_C / 11_65547388_T_G / 11_12162199_T_G / 5_181155466_T_G / 10_11921140_T_G 131 GNAI2_5 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 1011_Navitoclax_2 mitosis / rtk / chromatin / apop 1_149852603_A_G / 1_150261398_T_G / 17_55774876_T_G / 1_154627925_A_C / 17_77213881_T_G 132 DDX60_5 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 mitosis / rtk / DNArep / other 11_12162199_T_G / 16_87644643_G_A / 2_108507561_T_G / 5_181155466_T_G / 1_26774532_T_C 133 MICALL2_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 263_FR-180204_3 mitosis / chromatin / DNArep / erk_mapk 16_30953637_A_C / 11_12162199_T_G / 12_51745916_T_G 134 SOAT1_5 185_Linsitinib_2 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 igfr / rtk / mitosis / other 5_181155466_T_G / 5_38950065_A_T / 12_40313960_G_T / 17_51169925_C_T / 2_61492168_C_A 135 PLEC_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1 / 94_TGX221_3 cell_cyc / other / abl / pi3k 7_72942379_A_C 136 XRCC5_1 253_XMD14-99_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 rtk / erk_mapk / mitosis / DNArep 20_42084724_T_C 137 OSGEPL1_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 253_XMD14-99_3 erk_mapk / mitosis / chromatin / rtk 12_40313960_G_T 138 TMEM97_4 179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 1012_Vorinostat_1 / 300_CX-5461_3 DNArep / apop / chromatin / other 17_55774876_T_G / 20_33848655_A_C / 1_150261398_T_G / 12_6818898_A_C 139 GLIS3_4 185_Linsitinib_2 / 1091_BMS-536924_3 / 184_BMS-754807_2 / 1012_Vorinostat_1 igfr / igfr / igfr / chromatin 11_65547388_T_G / 2_66439901_A_C / 10_50311228_T_G / 8_41957277_G_C 140 ANXA1_5 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 185_Linsitinib_2 mitosis / rtk / chromatin / igfr 12_51745916_T_G / 5_181155466_T_G / 10_11921140_T_G / 13_113159942_A_G / 16_1817242_T_C 141 FAM120A_5 179_5-Fluorouracil_1 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 DNArep / rtk / mitosis / other 13_113159942_A_G / 3_128945112_G_A / 12_123499406_T_G / 20_42084724_T_C / 6_30705792_T_G 142 SAFB_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 305_TPCA-1_3 mitosis / chromatin / rtk / other 13_113159942_A_G / 14_55169342_TAAA_T / 10_11921140_T_G 143 ACTN4_4 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 mitosis / rtk / igfr / DNArep 11_12162199_T_G / 12_51745916_T_G / 10_73803641_A_G / 1_213007133_T_G 144 FAM117B_5 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 DNArep / mitosis / chromatin / other 5_181155466_T_G / 13_113159942_A_G / 1_15381304_A_C / 17_55774876_T_G / 10_11921140_T_G 145 TSSC1_1 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 263_FR-180204_3 igfr / mitosis / igfr / erk_mapk 2_113934259_C_T 146 SERPINE2_1 94_TGX221_3 / 56_WH-4-023_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 pi3k / abl / cell_cyc / other 7_72942379_A_C 147 IFNAR1_5 263_FR-180204_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 erk_mapk / chromatin / mitosis / DNArep 15_84241166_A_C / 6_30642116_A_G / 19_4911043_A_C / 16_259458_T_G / 19_7740447_T_G 148 UEVLD_3 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 DNArep / chromatin / mitosis / rtk 10_11921140_T_G / 11_43920052_A_C / X_2856636_A_C 149 GUF1_5 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 mitosis / igfr / DNArep / chromatin 11_65547388_T_G / 5_181155466_T_G / 1_213007133_T_G / 11_12162199_T_G / 17_55774876_T_G 150 GBP3_1 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 cell_cyc / pi3k / metabol / other 8_7290003_A_C 151 MED28_1 94_TGX221_3 / 344_THZ-2-49_3 / 156_AZD6482_2 / 196_Phenformin_3 pi3k / cell_cyc / pi3k / metabol 8_7290003_A_C 152 SLC2A10_1 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 cell_cyc / pi3k / metabol / other 8_7290003_A_C 153 CBR3_1 94_TGX221_3 / 1026_Tanespimycin_2 / 344_THZ-2-49_3 / 196_Phenformin_3 pi3k / other / cell_cyc / metabol 8_7290003_A_C 154 HIC2_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 94_TGX221_3 cell_cyc / other / metabol / pi3k 8_7290003_A_C 155 IGSF9_1 1026_Tanespimycin_2 / 94_TGX221_3 / 196_Phenformin_3 / 344_THZ-2-49_3 other / pi3k / metabol / cell_cyc 8_7290003_A_C 156 RCAN1_1 344_THZ-2-49_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 / 94_TGX221_3 cell_cyc / metabol / other / pi3k 8_7290003_A_C 157 SAFB_1 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 metabol / cell_cyc / pi3k / other 8_7290003_A_C 158 HNRNPA0_2 1012_Vorinostat_1 / 293_Amuvatinib_2 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2 chromatin / rtk / DNArep / apop 17_55774876_T_G / 16_55415_T_G 159 ISL1_1 196_Phenformin_3 / 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 metabol / pi3k / cell_cyc / other 7_72942379_A_C 160 PPIC_1 1012_Vorinostat_1 / 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 chromatin / igfr / mitosis / erk_mapk 2_66439901_A_C 161 CBX1_1 1011_Navitoclax_2 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 apop / other / DNArep / mitosis 20_42084724_T_C 162 ARID3B_1 1026_Tanespimycin_2 / 156_AZD6482_2 / 344_THZ-2-49_3 / 196_Phenformin_3 other / pi3k / cell_cyc / metabol 8_7290003_A_C 163 RNF157_1 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 281_Alectinib_2 / 304_SB52334_3 apop / DNArep / rtk / rtk 10_11921140_T_G 164 EIF3L_2 1012_Vorinostat_1 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 chromatin / igfr / DNArep / mitosis 17_51169925_C_T / 20_42084724_T_C 165 SLC25A43_2 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 344_THZ-2-49_3 pi3k / other / metabol / cell_cyc 8_7290003_A_C / 19_7627786_T_G 166 OLFML2A_1 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 / 51_Dasatinib_1 metabol / cell_cyc / pi3k / abl 7_72942379_A_C 167 HNRNPA1L2_4 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 1012_Vorinostat_1 mitosis / apop / other / chromatin 2_113934259_C_T / 12_40313960_G_T / 5_181155466_T_G / 12_51745916_T_G 168 GPR125_1 1011_Navitoclax_2 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 apop / rtk / mitosis / other 5_181155466_T_G 169 HFM1_5 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 mitosis / rtk / apop / DNArep 6_73622013_G_C / 6_73635330_C_T / 10_79312556_A_G / 15_55340661_G_T / 11_12162199_T_G 170 FAM161A_3 179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 / 1009_Tretinoin_1 DNArep / other / apop / other 3_165019547_G_T / 11_65547388_T_G / 7_100104762_T_G 171 MYO1E_5 1012_Vorinostat_1 / 1091_BMS-536924_3 / 281_Alectinib_2 / 221_TAK-715_2 chromatin / igfr / rtk / jnk_p38 12_51745916_T_G / 2_113934259_C_T / 15_40767895_T_G / 8_41957277_G_C / 2_157299566_T_G 172 BHLHE40_2 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 156_AZD6482_2 cell_cyc / metabol / pi3k / pi3k 7_72942379_A_C / 8_7290003_A_C 173 IPO9_1 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 300_CX-5461_3 / 275_I-BET-762_3 DNArep / chromatin / other / chromatin 12_51745916_T_G 174 MALT1_5 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 1091_BMS-536924_3 erk_mapk / mitosis / chromatin / igfr 11_12162199_T_G / 19_4911043_A_C / 12_40313960_G_T / 8_122952205_T_G / 17_7797836_A_C 175 GDPD1_1 179_5-Fluorouracil_1 / 226_GSK1070916_2 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 DNArep / mitosis / other / mitosis 9_69516199_A_C 176 CLIC1_5 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 1091_BMS-536924_3 mitosis / rtk / DNArep / igfr 16_1817242_T_C / 13_113159942_A_G / 6_30705800_T_G / 3_128945112_G_A / 5_181155466_T_G 177 GBP1_1 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 185_Linsitinib_2 / 304_SB52334_3 mitosis / igfr / igfr / rtk 11_12162199_T_G 178 WDR1_4 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 221_TAK-715_2 mitosis / rtk / DNArep / jnk_p38 13_113159942_A_G / 16_1817242_T_C / 18_79527652_GAA_G / 10_11921140_T_G 179 NOLC1_1 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 305_TPCA-1_3 chromatin / mitosis / erk_mapk / other 1_234373536_T_G 180 SUCLG2_1 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 304_SB52334_3 / 305_TPCA-1_3 mitosis / apop / rtk / other 2_113934259_C_T 181 TMEM50B_4 1012_Vorinostat_1 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 chromatin / erk_mapk / mitosis / mitosis 15_84241166_A_C / 6_30642116_A_G / 12_40313960_G_T / 10_27223356_T_C 182 TEP1_2 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 mitosis / other / DNArep / other 13_113159942_A_G / 1_160801918_G_C 183 C1QTNF4_1 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 300_CX-5461_3 / 304_SB52334_3 DNArep / mitosis / other / rtk 2_108507561_T_G 184 SAMD9_2 294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 1091_BMS-536924_3 / 1012_Vorinostat_1 mitosis / rtk / igfr / chromatin 11_12162199_T_G / 5_181155466_T_G 185 INTS2_1 226_GSK1070916_2 / 1012_Vorinostat_1 / 225_Genentech Cpd 10_3 / 305_TPCA-1_3 mitosis / chromatin / mitosis / other 20_42084724_T_C 186 FUBP1_1 253_XMD14-99_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 rtk / DNArep / mitosis / chromatin 16_28169801_A_C 187 RPAP1_1 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 304_SB52334_3 / 1012_Vorinostat_1 mitosis / igfr / rtk / chromatin 2_96842345_G_C 188 HEXB_1 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 metabol / cell_cyc / pi3k / other 15_75876091_T_G 189 HNRNPU_1 305_TPCA-1_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 269_NSC-207895_3 other / chromatin / mitosis / p53 15_65451964_A_G 190 FUCA1_2 294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 mitosis / chromatin / chromatin / DNArep 1_153341603_A_C / 11_12162199_T_G 191 NOTCH2_2 304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 rtk / mitosis / other / igfr 11_65547388_T_G / 13_113159942_A_G 192 CCT4_1 1012_Vorinostat_1 / 276_CAY10603_3 / 179_5-Fluorouracil_1 / 269_NSC-207895_3 chromatin / chromatin / DNArep / p53 7_108023984_G_A 193 UTRN_3 1012_Vorinostat_1 / 263_FR-180204_3 / 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 chromatin / erk_mapk / igfr / mitosis 7_108023984_G_A / 17_80962613_A_C / 19_4911043_A_C 194 CALU_1 94_TGX221_3 / 344_THZ-2-49_3 / 156_AZD6482_2 / 1026_Tanespimycin_2 pi3k / cell_cyc / pi3k / other 7_72942379_A_C 195 PLAUR_1 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 cell_cyc / pi3k / other / metabol 7_72942379_A_C 196 HIST1H3F_2 1012_Vorinostat_1 / 281_Alectinib_2 / 263_FR-180204_3 / 179_5-Fluorouracil_1 chromatin / rtk / erk_mapk / DNArep 9_35398502_T_G / 4_88731303_A_G 197 SHF_2 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 1012_Vorinostat_1 mitosis / rtk / igfr / chromatin 2_108507561_T_G / 7_149432379_A_C 198 CERK_1 281_Alectinib_2 / 1011_Navitoclax_2 / 300_CX-5461_3 / 253_XMD14-99_3 rtk / apop / other / rtk 2_29320789_A_C 199 TADA1_1 344_THZ-2-49_3 / 156_AZD6482_2 / 159_HG6-64-1_3 / 94_TGX221_3 cell_cyc / pi3k / erk_mapk / pi3k 18_41955194_A_G 200 UBA7_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / other / DNArep / rtk 3_128945112_G_A 201 SETDB1_1 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 253_XMD14-99_3 DNArep / mitosis / chromatin / rtk 10_11921140_T_G 202 FEV_1 196_Phenformin_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 1057_Dactolisib_2 metabol / cell_cyc / other / pi3k 2_105307612_A_C 203 PLIN3_1 294_MPS-1-IN-1_3 / 304_SB52334_3 / 281_Alectinib_2 / 185_Linsitinib_2 mitosis / rtk / rtk / igfr 11_12162199_T_G 204 CAPZB_1 253_XMD14-99_3 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 rtk / other / DNArep / mitosis 8_109289769_T_C 205 PRR14L_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 mitosis / DNArep / other / other 11_65547388_T_G 206 SYT4_1 281_Alectinib_2 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1091_BMS-536924_3 rtk / mitosis / igfr / igfr 1_247949628_T_C 207 OSTM1_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 293_Amuvatinib_2 mitosis / other / igfr / rtk 11_12162199_T_G 208 ALKBH2_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 293_Amuvatinib_2 chromatin / mitosis / igfr / rtk 11_12162199_T_G / 19_3281403_A_C / 1_228244520_T_G / 16_30953637_A_C / 8_27431326_A_G 209 MSN_1 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 185_Linsitinib_2 igfr / DNArep / chromatin / igfr 10_73803641_A_G 210 ESYT2_2 1012_Vorinostat_1 / 281_Alectinib_2 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 chromatin / rtk / igfr / DNArep 10_73803641_A_G / 19_4911043_A_C 211 RSBN1_1 304_SB52334_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 300_CX-5461_3 rtk / DNArep / other / other 13_113159942_A_G 212 ATL3_1 179_5-Fluorouracil_1 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 DNArep / other / mitosis / igfr 13_113159942_A_G 213 GLCCI1_2 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 281_Alectinib_2 mitosis / rtk / igfr / rtk 16_1817242_T_C / 13_113159942_A_G 214 STX4_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 mitosis / other / rtk / DNArep 13_113159942_A_G 215 ZFP36_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / other / DNArep / rtk 13_113159942_A_G 216 ITPR3_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 94_TGX221_3 / 196_Phenformin_3 cell_cyc / other / pi3k / metabol 20_33072178_T_G 217 APEX1_1 1012_Vorinostat_1 / 305_TPCA-1_3 / 293_Amuvatinib_2 / 275_I-BET-762_3 chromatin / other / rtk / chromatin 17_55774876_T_G 218 NAGK_1 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 305_TPCA-1_3 chromatin / DNArep / apop / other X_2856636_A_C 219 CTSO_2 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 300_CX-5461_3 DNArep / mitosis / erk_mapk / other 8_2963284_T_G / 19_6937330_T_G 220 GAL3ST3_5 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 mitosis / other / rtk 16_55415_T_G / X_100585180_G_T / 10_79312556_A_G / 19_7740447_T_G / 1_228244520_T_G 221 UBA52_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 mitosis / chromatin / other 13_113159942_A_G / 12_40313960_G_T / 11_65547388_T_G 222 MSRB3_4 304_SB52334_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 rtk / DNArep / mitosis 11_65547388_T_G / 2_108507561_T_G / 12_99655061_T_A / 13_113159942_A_G 223 MTPAP_3 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 DNArep / chromatin / mitosis 1_150261398_T_G / 11_65547388_T_G / 9_128964364_CT_C 224 UBE2O_4 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 chromatin / mitosis / rtk 20_42084724_T_C / 10_11921140_T_G / 6_30705800_T_G / 1_155747580_A_G 225 RANBP17_1 304_SB52334_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 rtk / mitosis / rtk 20_42084724_T_C 226 ZNF516_4 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 DNArep / mitosis / other 17_55774876_T_G / 9_37887606_C_T / 3_184301903_T_G / 1_234373536_T_G 227 NKAIN1_3 294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 mitosis / rtk / other 12_40313960_G_T / 13_113159942_A_G / 20_42084724_T_C 228 DHX9_3 269_NSC-207895_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 p53 / other / mitosis 2_113934259_C_T / 15_65451964_A_G / 7_44964464_T_C 229 TET1_4 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 mitosis / rtk / igfr 15_40767895_T_G / 12_51745916_T_G / 2_188994726_T_G / 17_55774876_T_G 230 UHMK1_1 310_YM201636_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 other / other / mitosis 8_30756677_T_G 231 KCNH8_2 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 pi3k / metabol / other 7_72942379_A_C / 20_62661184_C_T 232 PMEL_1 294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 263_FR-180204_3 mitosis / rtk / erk_mapk 20_42084724_T_C 233 TMEM177_2 1012_Vorinostat_1 / 253_XMD14-99_3 / 211_TL-2-105_3 chromatin / rtk / erk_mapk 12_40313960_G_T / 9_108900415_C_A 234 P4HB_3 305_TPCA-1_3 / 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 other / apop / mitosis 6_30329265_T_C / 2_113934259_C_T / 6_39884042_G_A 235 GLB1_2 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 other / mitosis / rtk 1_219979389_T_A / 1_54243266_A_G 236 NIPSNAP1_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 chromatin / mitosis / DNArep 2_86027990_C_A / 5_181155466_T_G / 2_60761746_T_G / 9_37887606_C_T / 12_51745916_T_G 237 STOX2_4 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 304_SB52334_3 mitosis / igfr / rtk 13_113159942_A_G / 11_65547388_T_G / 17_44212322_A_G / 16_1817242_T_C 238 HIC2_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 chromatin / mitosis / DNArep 11_12162199_T_G / 10_11921140_T_G / 5_181155466_T_G / 1_54243266_A_G / 14_67381608_G_T 239 DDX25_1 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 cell_cyc / pi3k / other 7_72942379_A_C 240 DNMT3A_1 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 cell_cyc / pi3k / metabol 7_72942379_A_C 241 EXT2_1 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 cell_cyc / pi3k / metabol 7_72942379_A_C 242 FAM129B_1 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 pi3k / cell_cyc / other 7_72942379_A_C 243 GINM1_1 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 cell_cyc / pi3k / metabol 7_72942379_A_C 244 HNRNPA1L2_1 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 pi3k / cell_cyc / other 7_72942379_A_C 245 MAN1B1_1 94_TGX221_3 / 196_Phenformin_3 / 344_THZ-2-49_3 pi3k / metabol / cell_cyc 7_72942379_A_C 246 TACC1_1 344_THZ-2-49_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 cell_cyc / metabol / other 7_72942379_A_C 247 RIPK1_5 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / DNArep / rtk 11_12162199_T_G / 1_234373536_T_G / 2_190469793_G_C / 16_1817242_T_C / 11_65547388_T_G 248 ZBTB4_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 mitosis / chromatin / DNArep 17_55774876_T_G / 10_11921140_T_G / 6_30705792_T_G 249 TLN1_5 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / DNArep / rtk 15_43578884_A_G / 13_113159942_A_G / 3_128945112_G_A / 11_12162199_T_G / 19_4911043_A_C 250 PCBP3_1 94_TGX221_3 / 51_Dasatinib_1 / 196_Phenformin_3 pi3k / abl / metabol 7_72942379_A_C 251 KIDINS220_2 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 305_TPCA-1_3 mitosis / igfr / other 2_113934259_C_T / 1_113549504_C_T 252 MYH9_4 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 mitosis / chromatin / DNArep 9_69516199_A_C / 13_113159942_A_G / 1_15381304_A_C / 10_11921140_T_G 253 C2orf43_4 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 185_Linsitinib_2 mitosis / erk_mapk / igfr 19_3281403_A_C / 20_42084724_T_C / 12_109800676_G_A / 7_108023984_G_A 254 CFLAR_5 1012_Vorinostat_1 / 304_SB52334_3 / 275_I-BET-762_3 chromatin / rtk / chromatin 17_55774876_T_G / 7_108023984_G_A / 5_181155466_T_G / 1_228244520_T_G / 5_38950065_A_T 255 RAB27A_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 chromatin / mitosis / other 12_6818898_A_C / 16_20737706_A_C / 2_66439901_A_C / 5_181155466_T_G / 11_12162199_T_G 256 PLSCR4_2 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 304_SB52334_3 mitosis / erk_mapk / rtk 16_55415_T_G / 17_51169925_C_T 257 RPUSD4_1 293_Amuvatinib_2 / 1012_Vorinostat_1 / 1091_BMS-536924_3 rtk / chromatin / igfr 15_75524142_T_C 258 MPST_3 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 DNArep / mitosis / chromatin 17_18353665_C_T / 1_150261398_T_G / 5_181155466_T_G 259 MSN_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 94_TGX221_3 cell_cyc / other / pi3k 8_7290003_A_C 260 TGFB1I1_1 1026_Tanespimycin_2 / 94_TGX221_3 / 344_THZ-2-49_3 other / pi3k / cell_cyc 8_7290003_A_C 261 PRMT1_2 1012_Vorinostat_1 / 263_FR-180204_3 / 221_TAK-715_2 chromatin / erk_mapk / jnk_p38 1_26034759_T_G / 5_181155466_T_G 262 AGPAT3_3 179_5-Fluorouracil_1 / 275_I-BET-762_3 / 265_Tubastatin A_3 DNArep / chromatin / chromatin 11_65547388_T_G / 1_183963850_T_G / 13_113159942_A_G 263 NUPR1_2 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 272_AR-42_2 mitosis / other / chromatin 11_20049928_A_C / 12_40313960_G_T 264 RNPC3_2 265_Tubastatin A_3 / 179_5-Fluorouracil_1 / 276_CAY10603_3 chromatin / DNArep / chromatin 20_5501817_T_G / 17_55774876_T_G 265 S100A6_2 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 cell_cyc / metabol / pi3k 8_7290003_A_C / 7_72942379_A_C 266 GADD45B_2 294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 1012_Vorinostat_1 mitosis / chromatin / chromatin 12_51745916_T_G / 11_12162199_T_G 267 IRF2_2_5 294_MPS-1-IN-1_3 / 269_NSC-207895_3 / 293_Amuvatinib_2 mitosis / p53 / rtk 1_149852603_A_G / 1_219979389_T_A 268 MVP_2_3 94_TGX221_3 / 344_THZ-2-49_3 / 196_Phenformin_3 pi3k / cell_cyc / metabol 11_68780792_C_A / 15_75876091_T_G 269 GTF2H5_2 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 184_BMS-754807_2 mitosis / igfr / igfr 3_165019547_G_T / 16_15664675_G_T 270 AGTPBP1_2 179_5-Fluorouracil_1 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 DNArep / other / mitosis 13_113159942_A_G / 11_65547388_T_G 271 TAGLN2_5 1091_BMS-536924_3 / 1011_Navitoclax_2 / 304_SB52334_3 igfr / apop / rtk 5_181155466_T_G / 12_7433515_G_T / 15_75524142_T_C / 20_2862756_T_G / 19_47441156_T_G 272 CCNT1_4 1012_Vorinostat_1 / 305_TPCA-1_3 / 269_NSC-207895_3 chromatin / other / p53 1_197912561_T_G / 5_115984518_A_T / 8_98032165_T_G / 15_65451964_A_G 273 KCNN4_1 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 metabol / cell_cyc / pi3k 8_7290003_A_C 274 PEA15_1 196_Phenformin_3 / 94_TGX221_3 / 344_THZ-2-49_3 metabol / pi3k / cell_cyc 8_7290003_A_C 275 SAMD9_1 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 metabol / cell_cyc / pi3k 8_7290003_A_C 276 TRADD_3 179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 DNArep / apop / mitosis 10_11921140_T_G / 13_113159942_A_G / 16_1817242_T_C 277 TAF5_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 mitosis / chromatin / rtk 6_33799054_A_G / 19_3281403_A_C / 7_108023984_G_A 278 EFHD2_4 1091_BMS-536924_3 / 304_SB52334_3 / 281_Alectinib_2 igfr / rtk / rtk 12_51745916_T_G / 1_213007133_T_G / 1_451649_A_AG / 2_61492168_C_A 279 YIPF2_1 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 1011_Navitoclax_2 mitosis / erk_mapk / apop 2_113934259_C_T 280 ZBED4_2 1012_Vorinostat_1 / 305_TPCA-1_3 / 1011_Navitoclax_2 chromatin / other / apop 2_108507561_T_G / 11_65547388_T_G 281 RAB3C_1 1026_Tanespimycin_2 / 196_Phenformin_3 / 344_THZ-2-49_3 other / metabol / cell_cyc 8_7290003_A_C 282 FOSL1_4 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 275_I-BET-762_3 other / DNArep / chromatin 12_57062993_T_G / 12_51745916_T_G / 13_39724512_C_T / 1_213007133_T_G 283 INA_2 294_MPS-1-IN-1_3 / 304_SB52334_3 / 263_FR-180204_3 mitosis / rtk / erk_mapk 13_113159942_A_G / 16_1817242_T_C 284 FLVCR1_2 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 253_XMD14-99_3 mitosis / DNArep / rtk 10_11921140_T_G / 11_12162199_T_G 285 ATF7IP2_5 1264_SGC0946_3 / 293_Amuvatinib_2 / 151_QS11_3 chromatin / rtk / other 17_55774876_T_G / 10_73803531_T_C / 2_63887264_C_CA / 3_9789934_A_C / 1_149852603_A_G 286 S100A10_1 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 304_SB52334_3 mitosis / rtk / rtk 10_11921140_T_G 287 TRIP6_1 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 chromatin / mitosis / igfr 12_51745916_T_G 288 EIF3J_2 1012_Vorinostat_1 / 257_NPK76-II-72-1_3 / 269_NSC-207895_3 chromatin / mitosis / p53 17_36429365_A_G / 1_237687398_C_T 289 CASP4_1 294_MPS-1-IN-1_3 / 304_SB52334_3 / 275_I-BET-762_3 mitosis / rtk / chromatin 12_51745916_T_G 290 NSL1_2 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 1012_Vorinostat_1 mitosis / apop / chromatin 11_12162199_T_G / 10_11921140_T_G 291 VASP_1 304_SB52334_3 / 294_MPS-1-IN-1_3 / 253_XMD14-99_3 rtk / mitosis / rtk 11_12162199_T_G 292 COG2_3 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 rtk / mitosis / DNArep 10_11921140_T_G / 16_87644643_G_A / 3_53891822_C_T 293 STMN4_3 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 263_FR-180204_3 mitosis / igfr / erk_mapk 13_113159942_A_G / 16_30953637_A_C / 16_1817242_T_C 294 ARID2_1 304_SB52334_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 rtk / mitosis / chromatin 11_12162199_T_G 295 TMEM145_2 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 179_5-Fluorouracil_1 mitosis / igfr / DNArep 10_11921140_T_G / 11_34452090_T_G 296 RPS28_2 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 mitosis / chromatin / other 15_43578884_A_G / 17_18282629_T_G 297 BHLHB9_5 300_CX-5461_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 other / apop / DNArep 2_224001859_C_A / 2_224001670_G_A / 3_128908178_A_G / 13_113159942_A_G / 3_128908109_T_C 298 CCT3_2 94_TGX221_3 / 344_THZ-2-49_3 / 156_AZD6482_2 pi3k / cell_cyc / pi3k 1_146969331_G_A / 1_16589114_C_T 299 ZBTB39_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 mitosis / DNArep / chromatin 16_30953637_A_C 300 TGFBI_1 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 253_XMD14-99_3 DNArep / mitosis / rtk 11_12162199_T_G 301 DRAM1_2 294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 179_5-Fluorouracil_1 mitosis / chromatin / DNArep 13_113159942_A_G / 12_40313960_G_T 302 TTC9B_4 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 mitosis / rtk / igfr 16_30953637_A_C / 16_1817242_T_C / 13_113159942_A_G / 3_128945112_G_A 303 CRABP1_2 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 263_FR-180204_3 mitosis / igfr / erk_mapk 12_40313960_G_T / 9_69516199_A_C 304 PRNP_1 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 275_I-BET-762_3 mitosis / igfr / chromatin 12_51745916_T_G 305 RNF216_2 344_THZ-2-49_3 / 156_AZD6482_2 / 199_Pazopanib_2 cell_cyc / pi3k / rtk 2_230310834_T_C / 2_230401046_T_C 306 KCNH2_1 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 mitosis / chromatin / erk_mapk 5_38950065_A_T 307 HDAC2_1 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 cell_cyc / metabol / pi3k 15_75876091_T_G 308 LDLRAD3_2 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 mitosis / apop / DNArep 11_65547388_T_G / 1_112653581_C_T 309 DLG2_1 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 mitosis / chromatin / erk_mapk 8_30756677_T_G 310 ABHD2_2 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 mitosis / other / rtk 20_31465452_G_A / 20_31476528_A_G 311 FICD_1 305_TPCA-1_3 / 310_YM201636_3 / 275_I-BET-762_3 other / other / chromatin 12_40313960_G_T 312 EML5_1 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 304_SB52334_3 mitosis / igfr / rtk 19_3281403_A_C 313 ZNF280B_1 179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 DNArep / other / apop 11_65547388_T_G 314 MAST1_1 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 mitosis / rtk / igfr 10_11921140_T_G 315 NBR2_4 1012_Vorinostat_1 / 221_TAK-715_2 / 226_GSK1070916_2 chromatin / jnk_p38 / mitosis 7_142944295_A_G / 7_142939444_T_G / 7_142939502_G_A / 19_3179506_A_C 316 ZSCAN16_1 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 pi3k / cell_cyc / other 16_72119226_C_G 317 CD109_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 mitosis / other / rtk 10_11921140_T_G 318 ASCL1_1 94_TGX221_3 / 196_Phenformin_3 / 156_AZD6482_2 pi3k / metabol / pi3k 7_72942379_A_C 319 PRCC_2 344_THZ-2-49_3 / 94_TGX221_3 / 156_AZD6482_2 cell_cyc / pi3k / pi3k 2_105307612_A_C / 19_8943580_T_G 320 SYPL1_3 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 mitosis / igfr / DNArep 16_1817242_T_C / 3_128945112_G_A / 1_150261398_T_G 321 CACNA1B_3 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 mitosis / apop / DNArep 13_113159942_A_G / X_2856636_A_C / 16_1817242_T_C 322 FEV_3 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 184_BMS-754807_2 igfr / mitosis / igfr 16_1817242_T_C / 13_113159942_A_G / 2_71515762_T_C 323 VSTM2A_2 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 179_5-Fluorouracil_1 mitosis / rtk / DNArep 13_113159942_A_G / 16_1817242_T_C 324 DOC2A_1 179_5-Fluorouracil_1 / 304_SB52334_3 / 294_MPS-1-IN-1_3 DNArep / rtk / mitosis 22_42212334_A_C 325 MTR_1 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 rtk / mitosis / rtk 2_61492168_C_A 326 TMEM184B_1 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 269_NSC-207895_3 chromatin / mitosis / p53 13_113159942_A_G 327 ARID2_3 344_THZ-2-49_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 cell_cyc / metabol / other 16_72129067_G_T / 16_72164743_G_A / 16_72119226_C_G 328 TSEN54_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 chromatin / mitosis / rtk 13_113325635_A_G / 11_12162199_T_G 329 LAMP2_1 1091_BMS-536924_3 / 1012_Vorinostat_1 / 263_FR-180204_3 igfr / chromatin / erk_mapk 6_33279455_T_G 330 GPX8_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 94_TGX221_3 cell_cyc / other / pi3k 16_72119226_C_G 331 PRIM1_1 1011_Navitoclax_2 / 1012_Vorinostat_1 / 288_WHI-P97_3 apop / chromatin / other 2_218827668_A_C 332 MMD_3 1012_Vorinostat_1 / 281_Alectinib_2 / 294_MPS-1-IN-1_3 chromatin / rtk / mitosis 1_248441636_T_G / 8_122952205_T_G / 6_30705792_T_G 333 HSPD1_1 1012_Vorinostat_1 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 chromatin / erk_mapk / mitosis 17_55774876_T_G 334 TNFRSF12A_5 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 igfr / DNArep / mitosis 2_60761746_T_G / 11_12162199_T_G / 5_181155466_T_G / 10_50311228_T_G / 13_113159942_A_G 335 PLP2_4 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 igfr / mitosis / apop 8_30756677_T_G / 5_181155466_T_G / 12_104287190_A_G / 6_33296240_C_A 336 SNX3_1 294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 226_GSK1070916_2 mitosis / rtk / mitosis 1_248441636_T_G 337 SMC3_1 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 other / mitosis / DNArep 11_65547388_T_G 338 ARHGAP1_1 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 other / DNArep / mitosis 13_113159942_A_G 339 LPP_1 94_TGX221_3 / 1026_Tanespimycin_2 / 1527_Pictilisib_2 pi3k / other / pi3k 18_909560_A_G 340 MGAT1_1 300_CX-5461_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 other / other / mitosis 13_113159942_A_G 341 TNFRSF1A_3 294_MPS-1-IN-1_3 / 304_SB52334_3 / 281_Alectinib_2 mitosis / rtk / rtk 13_39724512_C_T / 11_65547388_T_G / 17_55774876_T_G 342 C12orf10_1 1091_BMS-536924_3 / 1054_Palbociclib_2 / 1012_Vorinostat_1 igfr / cell_cyc / chromatin 10_73803641_A_G 343 KLF15_1 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 metabol / cell_cyc / pi3k 8_7259511_T_C 344 RSL1D1_1 1012_Vorinostat_1 / 333_T0901317_3 / 276_CAY10603_3 chromatin / other / chromatin 17_55774876_T_G 345 CDK2AP2_1 226_GSK1070916_2 / 275_I-BET-762_3 / 305_TPCA-1_3 mitosis / chromatin / other 13_113159942_A_G 346 ENOX1_1 294_MPS-1-IN-1_3 / 304_SB52334_3 / 275_I-BET-762_3 mitosis / rtk / chromatin 13_113159942_A_G 347 KLHL36_1 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 / 304_SB52334_3 apop / mitosis / rtk 13_113159942_A_G 348 C1R_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / DNArep / rtk 13_113159942_A_G 349 DLL3_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / DNArep / rtk 13_113159942_A_G 350 NPC1_1 1012_Vorinostat_1 / 185_Linsitinib_2 / 275_I-BET-762_3 chromatin / igfr / chromatin 6_106621398_T_C 351 BPTF_1 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 305_TPCA-1_3 DNArep / chromatin / other 17_55774876_T_G 352 CCNB1IP1_1 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 chromatin / DNArep / other 17_55774876_T_G 353 NPC2_1 304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 rtk / mitosis / other 13_113159942_A_G 354 ABAT_3 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 igfr / mitosis / igfr 16_24930679_T_G / 3_51381020_A_G / 19_18216930_A_C 355 CEP170_3 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G / 2_218266875_A_C / 11_65547388_T_G 356 NUCB1_3 253_XMD14-99_3 / 294_MPS-1-IN-1_3 rtk / mitosis 15_75524142_T_C / 1_26774532_T_C / 19_3281403_A_C 357 LAMP1_5 1012_Vorinostat_1 / 333_T0901317_3 chromatin / other 1_108718913_T_G / 5_181155466_T_G / 9_108900415_C_A / 2_154259039_T_G / 7_32543154_A_C 358 MAP4_2 94_TGX221_3 / 1026_Tanespimycin_2 pi3k / other 7_72942379_A_C / 8_7290003_A_C 359 MSH6_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 mitosis / other 20_42084724_T_C 360 NECAP2_5 179_5-Fluorouracil_1 / 300_CX-5461_3 DNArep / other 1_45019269_T_G / 13_113159942_A_G / 16_1817242_T_C / 17_55774876_T_G / 9_37887606_C_T 361 RFX7_1 275_I-BET-762_3 / 305_TPCA-1_3 chromatin / other 15_65451964_A_G 362 LOXL1_1 94_TGX221_3 / 344_THZ-2-49_3 pi3k / cell_cyc 7_72942379_A_C 363 RAB11FIP5_1 344_THZ-2-49_3 / 94_TGX221_3 cell_cyc / pi3k 7_72942379_A_C 364 SYNC_1 344_THZ-2-49_3 / 94_TGX221_3 cell_cyc / pi3k 7_72942379_A_C 365 MYT1_2 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 17_41725799_T_G / 20_42084724_T_C 366 CNTNAP2_4 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 mitosis / DNArep 2_108507561_T_G / 13_113159942_A_G / X_2856636_A_C / 16_55415_T_G 367 SMARCA5_4 305_TPCA-1_3 / 294_MPS-1-IN-1_3 other / mitosis 15_65451964_A_G / 17_81086334_C_G / 11_65547388_T_G / 12_40313960_G_T 368 B3GNT9_4 179_5-Fluorouracil_1 / 1011_Navitoclax_2 DNArep / apop 15_66561152_T_G / 17_55774876_T_G / 11_65547388_T_G / 7_108023984_G_A 369 GAL_2 1012_Vorinostat_1 / 1091_BMS-536924_3 chromatin / igfr 2_66439901_A_C / 9_37887606_C_T 370 TRIM56_5 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 DNArep / mitosis 17_55774876_T_G / 13_113159942_A_G / 20_42084724_T_C / 16_1817242_T_C / 16_30953637_A_C 371 CRIM1_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 mitosis / chromatin 12_40313960_G_T / 1_20724406_A_C / 17_44212322_A_G 372 PNMA3_5 294_MPS-1-IN-1_3 / 293_Amuvatinib_2 mitosis / rtk 2_113934259_C_T / 16_55415_T_G / 20_16044565_T_G / 22_17727059_T_G / 1_149852603_A_G 373 HIST3H2A_3 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 10_11921140_T_G / 16_18379704_T_G / 20_16044565_T_G 374 ATCAY_5 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 13_113159942_A_G / 16_30953637_A_C / 16_1817242_T_C / 6_33279455_T_G / 9_5549463_A_C 375 SMARCA4_2 1012_Vorinostat_1 / 1011_Navitoclax_2 chromatin / apop 11_65547388_T_G / 5_181155466_T_G 376 LIN28B_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 5_181155466_T_G / 2_113934259_C_T 377 OLFML2A_5 263_FR-180204_3 / 294_MPS-1-IN-1_3 erk_mapk / mitosis 2_154854926_A_C / 17_7797836_A_C / 6_30705792_T_G / 11_65547388_T_G / 15_84241166_A_C 378 ACP1_5 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 mitosis / apop 19_3281403_A_C / 2_113934259_C_T / 5_181155466_T_G / 2_86604885_C_A / 11_12162199_T_G 379 ACTL6B_3 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 16_1817242_T_C / 13_113159942_A_G / 11_43920052_A_C 380 PHF21B_4 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G / 16_1817242_T_C / 11_12162199_T_G / 16_30953637_A_C 381 BAZ1A_1 1012_Vorinostat_1 / 275_I-BET-762_3 chromatin / chromatin 15_65451964_A_G 382 TMEM30A_1 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 mitosis / igfr 12_104287190_A_G 383 NOL11_2 344_THZ-2-49_3 / 94_TGX221_3 cell_cyc / pi3k 8_7290003_A_C / 1_1918090_A_G 384 BEND4_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 5_181155466_T_G / 6_37022626_A_C / 2_237368621_T_G / 12_6818898_A_C / 12_51745916_T_G 385 ELOVL1_3 185_Linsitinib_2 / 179_5-Fluorouracil_1 igfr / DNArep 13_113159942_A_G / 16_1817242_T_C / 9_37887606_C_T 386 PFKM_4 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 igfr / mitosis 13_20031246_A_C / 9_37887606_C_T / 20_16044565_T_G / 10_79312556_A_G 387 NMNAT1_2 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 15_82519765_A_C / 19_3281403_A_C 388 TIGD1_2 1012_Vorinostat_1 / 179_5-Fluorouracil_1 chromatin / DNArep 17_55774876_T_G / 1_150261398_T_G 389 ARL1_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 9_93293047_T_G / 13_113159942_A_G / 12_51745916_T_G / 6_25488355_C_T / 6_25510468_CAT_C 390 CPLX1_4 263_FR-180204_3 / 294_MPS-1-IN-1_3 erk_mapk / mitosis 16_1817242_T_C / 13_113159942_A_G / 16_30953637_A_C / 18_79527652_GAA_G 391 PAX6_5 1012_Vorinostat_1 / 263_FR-180204_3 chromatin / erk_mapk 1_234309145_T_G / 1_156286332_T_G / 1_54243266_A_G / 12_44376791_T_A / 10_50311228_T_G 392 ANXA2_5 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 apop / mitosis 12_57178583_A_C / 2_86604885_C_A / 5_181155466_T_G / 6_33296240_C_A / 8_30756677_T_G 393 BHLHE41_1 305_TPCA-1_3 / 185_Linsitinib_2 other / igfr 2_113934259_C_T 394 DPYSL5_2 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G / 2_108507561_T_G 395 NCL_5 1012_Vorinostat_1 / 305_TPCA-1_3 chromatin / other 17_55774876_T_G / 19_3281403_A_C / 7_108023984_G_A / 11_65547388_T_G / 13_113159942_A_G 396 NEK6_3 294_MPS-1-IN-1_3 / 185_Linsitinib_2 mitosis / igfr 11_12162199_T_G / 13_39724512_C_T / 10_50311228_T_G 397 ADAM11_1 253_XMD14-99_3 / 294_MPS-1-IN-1_3 rtk / mitosis 9_128964364_CT_C 398 BMP1_1 94_TGX221_3 / 196_Phenformin_3 pi3k / metabol 7_72942379_A_C 399 CRABP1_1 344_THZ-2-49_3 / 94_TGX221_3 cell_cyc / pi3k 7_72942379_A_C 400 CREB3_1 94_TGX221_3 / 344_THZ-2-49_3 pi3k / cell_cyc 7_72942379_A_C 401 CTSB_1 196_Phenformin_3 / 94_TGX221_3 metabol / pi3k 7_72942379_A_C 402 GLB1_1 196_Phenformin_3 / 94_TGX221_3 metabol / pi3k 7_72942379_A_C 403 LGALS3_1 196_Phenformin_3 / 94_TGX221_3 metabol / pi3k 7_72942379_A_C 404 SMPD1_1 94_TGX221_3 / 344_THZ-2-49_3 pi3k / cell_cyc 7_72942379_A_C 405 GTPBP4_1 263_FR-180204_3 / 1012_Vorinostat_1 erk_mapk / chromatin 12_40313960_G_T 406 ACTR3B_2 294_MPS-1-IN-1_3 / 310_YM201636_3 mitosis / other 13_113159942_A_G / 5_170034543_C_T 407 CSRP1_3 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 10_11921140_T_G / 2_27774175_G_T / 17_55774876_T_G 408 SEPHS1_1 1012_Vorinostat_1 / 305_TPCA-1_3 chromatin / other 2_113934259_C_T 409 ACTN2_1 253_XMD14-99_3 / 294_MPS-1-IN-1_3 rtk / mitosis 1_213007133_T_G 410 NMRK1_2 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 mitosis / chromatin 12_7433515_G_T / 16_55415_T_G 411 TFAP2A_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 erk_mapk / mitosis 3_165019547_G_T 412 CAV1_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 mitosis / chromatin 17_81086334_C_G / 13_39724512_C_T / 12_51745916_T_G 413 PQLC3_2 1012_Vorinostat_1 / 179_5-Fluorouracil_1 chromatin / DNArep 10_11921140_T_G / 16_18379704_T_G 414 RPL9_4 179_5-Fluorouracil_1 / 305_TPCA-1_3 DNArep / other 11_12162199_T_G / 3_165019547_G_T / 11_65547388_T_G / 16_72788732_T_G 415 H2AFY2_3 185_Linsitinib_2 / 294_MPS-1-IN-1_3 igfr / mitosis 10_11921140_T_G / 1_213007133_T_G / 11_12162199_T_G 416 MCM10_1 1011_Navitoclax_2 / 1012_Vorinostat_1 apop / chromatin 2_170965958_A_C 417 G6PD_1 179_5-Fluorouracil_1 / 300_CX-5461_3 DNArep / other 16_87644643_G_A 418 TADA1_1 179_5-Fluorouracil_1 / 1012_Vorinostat_1 DNArep / chromatin 10_11921140_T_G 419 KCNC1_5 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 16_30953637_A_C / 9_5549463_A_C / 17_76472531_A_C / 11_43920052_A_C / 16_1817242_T_C 420 JPH4_1 294_MPS-1-IN-1_3 / 281_Alectinib_2 mitosis / rtk 12_40313960_G_T 421 ZNF121_3 263_FR-180204_3 / 179_5-Fluorouracil_1 erk_mapk / DNArep 13_113159942_A_G / 16_1817242_T_C / 11_12162199_T_G 422 TMEM206_1 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 9_69516199_A_C 423 HS3ST4_1 179_5-Fluorouracil_1 / 300_CX-5461_3 DNArep / other 3_128945112_G_A 424 MRPL48_1 1264_SGC0946_3 / 1012_Vorinostat_1 chromatin / chromatin 5_181155466_T_G 425 PPAT_5 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 mitosis / chromatin 8_27431326_A_G / 1_228244520_T_G / 6_56557393_C_T / 1_46261223_G_A / 1_234373536_T_G 426 CELF3_3 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 3_128908109_T_C / 16_1817242_T_C / 3_128945112_G_A 427 ABCC8_1 294_MPS-1-IN-1_3 / 281_Alectinib_2 mitosis / rtk 3_128945112_G_A 428 KIF1C_4 304_SB52334_3 / 294_MPS-1-IN-1_3 rtk / mitosis 13_113159942_A_G / 19_43359207_C_A / 16_1817242_T_C / 9_93293047_T_G 429 MOSPD2_1 263_FR-180204_3 / 1012_Vorinostat_1 erk_mapk / chromatin 11_12162199_T_G 430 ANKRD46_1 304_SB52334_3 / 294_MPS-1-IN-1_3 rtk / mitosis 10_11921140_T_G 431 RSL24D1_1 1012_Vorinostat_1 / 1091_BMS-536924_3 chromatin / igfr 9_69516199_A_C 432 HNRNPC_1 94_TGX221_3 / 196_Phenformin_3 pi3k / metabol 8_7290003_A_C 433 LYST_1 196_Phenformin_3 / 94_TGX221_3 metabol / pi3k 8_7290003_A_C 434 MRPS31_2 304_SB52334_3 / 1012_Vorinostat_1 rtk / chromatin 1_112520503_A_G / 11_65547388_T_G 435 ANXA11_1 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 DNArep / mitosis 16_1817242_T_C 436 GABRB3_2 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 mitosis / DNArep 13_113159942_A_G / 16_1817242_T_C 437 ITGB5_4 179_5-Fluorouracil_1 / 1012_Vorinostat_1 DNArep / chromatin 2_154854926_A_C / 1_234373536_T_G / 11_65547388_T_G / 17_55774876_T_G 438 TAGLN_5 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 2_157299566_T_G / 22_18345007_A_C / 1_54243266_A_G / 1_156286332_T_G / X_49565582_A_C 439 KLF6_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 mitosis / other 12_95474188_T_G 440 GLIS3_1 344_THZ-2-49_3 / 196_Phenformin_3 cell_cyc / metabol 8_7290003_A_C 441 GRPEL2_3 1012_Vorinostat_1 / 179_5-Fluorouracil_1 chromatin / DNArep 9_108900415_C_A / 5_133233474_T_G / 10_11921140_T_G 442 SORCS1_2 294_MPS-1-IN-1_3 / 281_Alectinib_2 mitosis / rtk 16_259458_T_G / 13_113159942_A_G 443 TAF3_1 344_THZ-2-49_3 / 94_TGX221_3 cell_cyc / pi3k 15_75876091_T_G 444 ZNF638_4 304_SB52334_3 / 269_NSC-207895_3 rtk / p53 10_73803531_T_C / 13_39724512_C_T / 22_17727059_T_G / 5_427675_T_C 445 RPAIN_2 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 9_69516199_A_C / 11_18089364_C_A 446 PRMT6_2 275_I-BET-762_3 / 305_TPCA-1_3 chromatin / other 7_35240878_C_T / 3_53872486_G_A 447 CERCAM_1 1012_Vorinostat_1 / 305_TPCA-1_3 chromatin / other 6_30705792_T_G 448 TWSG1_1 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 12_51745916_T_G 449 NAP1L1_1 305_TPCA-1_3 / 272_AR-42_2 other / chromatin 7_2269556_T_A 450 NQO2_1 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 DNArep / mitosis 10_79312556_A_G 451 EXOSC5_1 1012_Vorinostat_1 / 179_5-Fluorouracil_1 chromatin / DNArep 7_108023984_G_A 452 LTBP2_1 196_Phenformin_3 / 344_THZ-2-49_3 metabol / cell_cyc 11_68780792_C_A 453 KIAA1549_3 304_SB52334_3 / 294_MPS-1-IN-1_3 rtk / mitosis 17_75834935_G_A / 15_40855887_C_T / 15_40855965_C_T 454 LRP10_2 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 11_65547388_T_G / 17_55774876_T_G 455 CIB1_4 185_Linsitinib_2 / 1012_Vorinostat_1 igfr / chromatin 13_113159942_A_G / 1_150261398_T_G / 16_1817242_T_C / 1_149852603_A_G 456 RPL19_1 1012_Vorinostat_1 / 226_GSK1070916_2 chromatin / mitosis 2_61492168_C_A 457 CBX2_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 10_73803641_A_G / 17_80352778_T_G 458 CLVS2_2 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 igfr / mitosis 2_108507561_T_G / 11_65547388_T_G 459 GLIPR1_2 1012_Vorinostat_1 / 179_5-Fluorouracil_1 chromatin / DNArep 19_4911043_A_C / 10_11921140_T_G 460 TAPBP_3 294_MPS-1-IN-1_3 / 275_I-BET-762_3 mitosis / chromatin 11_12162199_T_G / 16_30953637_A_C / 12_40313960_G_T 461 GNA12_3 179_5-Fluorouracil_1 / 300_CX-5461_3 DNArep / other 13_113325626_T_C / 7_129389033_T_G / 12_51745916_T_G 462 MBNL1_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 mitosis / DNArep 9_69516199_A_C 463 ISYNA1_2 344_THZ-2-49_3 / 156_AZD6482_2 cell_cyc / pi3k 15_43716974_A_C / 3_197683305_A_C 464 PRLHR_2 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 10_26746549_C_T / 6_56067480_C_T 465 IQGAP1_5 1091_BMS-536924_3 / 1012_Vorinostat_1 igfr / chromatin 8_122952205_T_G / 3_128945112_G_A / 13_113325635_A_G / 19_9566733_T_G / 5_181155466_T_G 466 SDC4_2 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 mitosis / DNArep 12_40313960_G_T / 13_113159942_A_G 467 NAA25_1 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 7_108023984_G_A 468 PLEKHA4_1 294_MPS-1-IN-1_3 / 226_GSK1070916_2 mitosis / mitosis 7_2269556_T_A 469 TUBA4A_2 1012_Vorinostat_1 / 1091_BMS-536924_3 chromatin / igfr 7_159142364_T_G / 11_65547388_T_G 470 SLC35D1_1 293_Amuvatinib_2 / 1012_Vorinostat_1 rtk / chromatin 16_18379704_T_G 471 SH3GLB1_1 1012_Vorinostat_1 / 1011_Navitoclax_2 chromatin / apop 20_42084724_T_C 472 RPL37_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 mitosis / other 11_12162199_T_G 473 KDELR3_3 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 16_72119226_C_G / 16_72129067_G_T / 16_72164743_G_A 474 DDX60L_1 1011_Navitoclax_2 / 179_5-Fluorouracil_1 apop / DNArep 11_12162199_T_G 475 GNPDA2_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 3_191358113_C_T 476 DPY30_1 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 14_23276467_A_G 477 MURC_2 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 apop / mitosis 17_73203001_T_G / 8_61583890_T_A 478 CCDC80_2 344_THZ-2-49_3 / 94_TGX221_3 cell_cyc / pi3k 16_72119226_C_G / 16_72129067_G_T 479 C12orf23_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 16_72119226_C_G 480 LOX_1 344_THZ-2-49_3 / 94_TGX221_3 cell_cyc / pi3k 16_72119226_C_G 481 CEP68_3 185_Linsitinib_2 / 304_SB52334_3 igfr / rtk 13_113159942_A_G / 8_12430448_C_T / 17_55774876_T_G 482 BEND3_1 196_Phenformin_3 / 344_THZ-2-49_3 metabol / cell_cyc 15_75876091_T_G 483 RPRD2_3 156_AZD6482_2 / 344_THZ-2-49_3 pi3k / cell_cyc 1_146975626_G_A / 1_146969331_G_A / 1_148117837_C_T 484 ELAVL4_3 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G / 7_108023984_G_A / 7_108024001_C_T 485 TRIM21_1 294_MPS-1-IN-1_3 / 253_XMD14-99_3 mitosis / rtk 1_237687398_C_T 486 PRPF40B_1 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 mitosis / igfr 17_64146068_T_G 487 DCLRE1A_1 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 1_219979389_T_A 488 DUSP12_1 1012_Vorinostat_1 / 304_SB52334_3 chromatin / rtk 15_75524142_T_C 489 TFPI_2 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 mitosis / apop 1_213007133_T_G / 16_1817242_T_C 490 MYO1C_2 1011_Navitoclax_2 / 304_SB52334_3 apop / rtk 11_65547388_T_G / 13_113159942_A_G 491 SYDE1_1 94_TGX221_3 / 344_THZ-2-49_3 pi3k / cell_cyc 18_41955194_A_G 492 RANBP1_1 1012_Vorinostat_1 / 288_WHI-P97_3 chromatin / other 6_30705792_T_G 493 PRAME_3 179_5-Fluorouracil_1 / 1009_Tretinoin_1 DNArep / other 16_67909562_C_A / 22_42212334_A_C / 19_57720377_A_G 494 PNN_1 305_TPCA-1_3 / 179_5-Fluorouracil_1 other / DNArep 13_39724512_C_T 495 PHF11_3 300_CX-5461_3 / 305_TPCA-1_3 other / other 11_12162199_T_G / X_2856636_A_C / X_119150617_A_C 496 WDR35_1 185_Linsitinib_2 / 294_MPS-1-IN-1_3 igfr / mitosis 12_109800676_G_A 497 KCNN4_5 1091_BMS-536924_3 / 1012_Vorinostat_1 igfr / chromatin 5_181155466_T_G / 20_45938939_T_G / 10_11921140_T_G / 1_15381304_A_C / 10_50311228_T_G 498 SERPINB6_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 2_227062473_GT_G 499 ACOT9_5 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 mitosis / igfr 10_11921140_T_G / 11_12162199_T_G / 3_128945112_G_A / 13_113159942_A_G / 6_29631350_A_G 500 LAMP1_2 344_THZ-2-49_3 / 196_Phenformin_3 cell_cyc / metabol 1_99728613_A_C / 7_72942379_A_C 501 C19orf10_2 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 16_72129067_G_T / 16_72119226_C_G 502 EHD2_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 mitosis / DNArep 6_10410133_T_G 503 DPH5_1 1012_Vorinostat_1 / 1054_Palbociclib_2 chromatin / cell_cyc 8_12430448_C_T 504 TMEM169_1 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 1_112520503_A_G 505 SMARCB1_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 3_197683305_A_C 506 PLEKHF2_1 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 7_108023984_G_A 507 HSF2_5 179_5-Fluorouracil_1 / 1011_Navitoclax_2 DNArep / apop 11_65547388_T_G / 2_178663651_C_T / 1_234373536_T_G / 16_67878678_T_G / 2_178689190_G_A 508 ASPH_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 2_105307612_A_C 509 SERINC3_1 344_THZ-2-49_3 / 196_Phenformin_3 cell_cyc / metabol 2_105307612_A_C 510 THOC5_1 196_Phenformin_3 / 344_THZ-2-49_3 metabol / cell_cyc 3_197683305_A_C 511 SLC6A15_1 253_XMD14-99_3 / 294_MPS-1-IN-1_3 rtk / mitosis 17_55774876_T_G 512 TBC1D2_1 1012_Vorinostat_1 / 305_TPCA-1_3 chromatin / other 1_185150475_G_A 513 HSPG2_1 344_THZ-2-49_3 / 51_Dasatinib_1 cell_cyc / abl 1_37703244_A_C 514 CACNA2D2_1 294_MPS-1-IN-1_3 / 185_Linsitinib_2 mitosis / igfr 17_76472531_A_C 515 SLC5A6_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 7_108023984_G_A / 14_22844242_T_G 516 DAZAP1_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 6_73622013_G_C / 6_73635330_C_T 517 NFIX_2 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 mitosis / DNArep 10_101004037_A_C / 12_109800676_G_A 518 ELAVL3_3 196_Phenformin_3 / 344_THZ-2-49_3 metabol / cell_cyc 2_15474280_T_C / 2_15475786_A_G / 2_15467718_T_C 519 COPB2_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 19_16503339_T_G 520 ZNF219_1 1026_Tanespimycin_2 / 156_AZD6482_2 other / pi3k 15_43716974_A_C 521 RNF165_2 294_MPS-1-IN-1_3 / 281_Alectinib_2 mitosis / rtk 10_11921140_T_G / 16_1817242_T_C 522 P4HA1_1 1011_Navitoclax_2 / 281_Alectinib_2 apop / rtk 16_58525116_G_T 523 CIB2_3 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 11_33583339_C_T / 11_33583414_C_T / 11_33606557_T_G 524 LMAN2_1 305_TPCA-1_3 / 294_MPS-1-IN-1_3 other / mitosis 11_65547388_T_G 525 POFUT1_1 1026_Tanespimycin_2 / 104_Bortezomib_1 other / other 4_118640836_A_T 526 ITGB1_1 94_TGX221_3 / 344_THZ-2-49_3 pi3k / cell_cyc 20_46216899_A_C 527 GFPT2_2 156_AZD6482_2 / 94_TGX221_3 pi3k / pi3k 7_72942379_A_C / 1_12938859_G_A 528 SNTB2_2 1026_Tanespimycin_2 / 94_TGX221_3 other / pi3k 5_36985201_A_G / 5_37000972_A_G 529 FAM126A_1 304_SB52334_3 / 294_MPS-1-IN-1_3 rtk / mitosis 1_451649_A_AG 530 FAM214B_1 1012_Vorinostat_1 / 345_KIN001-270_3 chromatin / cell_cyc 20_24959779_A_C 531 E2F5_1 1012_Vorinostat_1 / 221_TAK-715_2 chromatin / jnk_p38 19_16896123_T_G 532 CRMP1_1 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G 533 DTX3L_1 304_SB52334_3 / 294_MPS-1-IN-1_3 rtk / mitosis 13_113159942_A_G 534 ELAVL3_1 304_SB52334_3 / 294_MPS-1-IN-1_3 rtk / mitosis 13_113159942_A_G 535 GATA2_1 294_MPS-1-IN-1_3 / 185_Linsitinib_2 mitosis / igfr 13_113159942_A_G 536 GNG4_1 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G 537 GPX8_1 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G 538 LATS2_1 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G 539 TMEM87B_1 1011_Navitoclax_2 / 304_SB52334_3 apop / rtk 1_237687398_C_T 540 NR2C1_1 305_TPCA-1_3 / 1091_BMS-536924_3 other / igfr 9_88647472_G_A 541 CHMP4B_1 333_T0901317_3 / 1012_Vorinostat_1 other / chromatin 16_66912991_CGT_C 542 HPDL_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 mitosis / DNArep 6_41770599_T_G 543 HNRPDL_1 1012_Vorinostat_1 / 1011_Navitoclax_2 chromatin / apop 17_55774876_T_G 544 MICB_1 275_I-BET-762_3 / 304_SB52334_3 chromatin / rtk 17_81086334_C_G 545 C17orf53_5 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / erk_mapk 3_128481377_A_C / 7_142940415_T_G / 17_74777339_T_G / X_24788994_C_T / 19_39885857_T_G 546 WDR3_1 276_CAY10603_3 / 1012_Vorinostat_1 chromatin / chromatin 5_88722571_GA_G 547 FKBP15_1 196_Phenformin_3 / 344_THZ-2-49_3 metabol / cell_cyc 2_200493236_A_C 548 SLC22A23_1 94_TGX221_3 pi3k 7_72942379_A_C 549 ST6GALNAC3_1 344_THZ-2-49_3 cell_cyc 7_72942379_A_C 550 RCAN1_3 1012_Vorinostat_1 chromatin 11_65547388_T_G / 2_66439901_A_C / 7_159142364_T_G 551 CCDC107_2 94_TGX221_3 pi3k 7_72942379_A_C / 20_62661184_C_T 552 PAX6_2 94_TGX221_3 pi3k 7_72942379_A_C / 7_5227302_G_C 553 IGSF9_5 1012_Vorinostat_1 chromatin 16_87644643_G_A / 5_181155466_T_G / 13_113325635_A_G / 12_6818898_A_C / 11_12162199_T_G 554 TFAP4_2 1012_Vorinostat_1 chromatin 5_181155466_T_G / 11_65547388_T_G 555 B2M_5 294_MPS-1-IN-1_3 mitosis 11_12162199_T_G / 12_6818898_A_C / 20_42084724_T_C / 1_108718913_T_G / 3_128945112_G_A 556 ZCCHC12_1 1166_QL-VIII-58_3 tor 1_1676790_C_T 557 MYL12B_3 294_MPS-1-IN-1_3 mitosis 2_108507561_T_G / X_38285780_G_A / 1_237687398_C_T 558 SHPRH_5 179_5-Fluorouracil_1 DNArep 11_65547388_T_G / 17_55774876_T_G / 2_108507561_T_G / 22_42212334_A_C / 13_113159942_A_G 559 NRSN1_4 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 16_30953637_A_C / 16_1817242_T_C / 9_93293047_T_G 560 HNRNPR_3 288_WHI-P97_3 other 17_40348252_T_G / 10_101004037_A_C / 17_73203001_T_G 561 RRAGC_2 263_FR-180204_3 erk_mapk 9_37887606_C_T / 10_79312556_A_G 562 CTSA_3 1012_Vorinostat_1 chromatin 11_12162199_T_G / 5_181155466_T_G / 16_87644643_G_A 563 DUSP26_3 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 15_43578884_A_G / 16_1817242_T_C 564 IFI35_2 294_MPS-1-IN-1_3 mitosis 11_12162199_T_G / 16_30953637_A_C 565 FAM163A_4 294_MPS-1-IN-1_3 mitosis 16_30953637_A_C / 6_33279455_T_G / 20_16044565_T_G / 2_113934259_C_T 566 DHX15_3 294_MPS-1-IN-1_3 mitosis 1_26774532_T_C / 19_3281403_A_C / 11_12162199_T_G 567 WDR86_3 305_TPCA-1_3 other 16_87644643_G_A / 20_42084724_T_C / 19_9566733_T_G 568 CECR5_1 1012_Vorinostat_1 chromatin 5_181155466_T_G 569 VASH2_1 1012_Vorinostat_1 chromatin 5_181155466_T_G 570 KCNH8_2 294_MPS-1-IN-1_3 mitosis 3_100302035_G_T / 2_169735166_A_C 571 MRPS25_3 179_5-Fluorouracil_1 DNArep 15_75524142_T_C / 9_37887606_C_T / 1_213007133_T_G 572 COPS7B_4 1012_Vorinostat_1 chromatin 10_11921140_T_G / 19_3281403_A_C / 1_150261398_T_G / 10_97048952_T_G 573 PHYHIPL_2 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 16_30953637_A_C 574 ATP6V0E1_3 294_MPS-1-IN-1_3 mitosis 12_40313960_G_T / 11_12162199_T_G / 15_43211582_A_C 575 CEP44_5 294_MPS-1-IN-1_3 mitosis 11_12162199_T_G / 10_11921140_T_G / 17_55774876_T_G / 11_65547388_T_G / 10_27223356_T_C 576 SEC22C_1 305_TPCA-1_3 other 15_65451964_A_G 577 TRIM38_2 294_MPS-1-IN-1_3 mitosis 15_43578884_A_G / 17_51169925_C_T 578 MTF2_1 1026_Tanespimycin_2 other 7_72942379_A_C 579 ZC3H15_4 263_FR-180204_3 erk_mapk 2_154854926_A_C / 7_149253814_T_G / 20_63929447_G_C / 3_196782572_G_T 580 THOC5_2 1012_Vorinostat_1 chromatin 1_54243266_A_G / 22_22098988_G_T 581 CLASP2_2 185_Linsitinib_2 igfr 9_37887606_C_T / 16_1817242_T_C 582 SLC18A2_2 294_MPS-1-IN-1_3 mitosis 16_30953637_A_C / 10_101004037_A_C 583 NDUFAF4_4 1012_Vorinostat_1 chromatin 11_65547388_T_G / 1_234373536_T_G / 15_65451964_A_G / 15_75524142_T_C 584 CHD4_1 1012_Vorinostat_1 chromatin 12_51745916_T_G 585 KIF5A_3 294_MPS-1-IN-1_3 mitosis 16_1817242_T_C / 11_12162199_T_G / 1_20724406_A_C 586 CNN2_2 294_MPS-1-IN-1_3 mitosis 11_12162199_T_G / 11_94082585_T_C 587 DCBLD1_2 294_MPS-1-IN-1_3 mitosis 10_26746549_C_T / 11_12162199_T_G 588 SPSB4_2 304_SB52334_3 rtk 15_55340661_G_T / 15_55329691_T_C 589 EDIL3_1 263_FR-180204_3 erk_mapk 11_12162199_T_G 590 GALNT10_3 294_MPS-1-IN-1_3 mitosis 6_30705792_T_G / 11_65547388_T_G / 12_40313960_G_T 591 H1FX_1 294_MPS-1-IN-1_3 mitosis 11_73355795_A_G 592 OSGIN1_4 275_I-BET-762_3 chromatin 4_61579528_T_C / 3_53871281_T_C / 3_53872486_G_A / 3_53888593_A_G 593 PRRX1_1 94_TGX221_3 pi3k 10_96527504_G_C 594 SERF2_1 1012_Vorinostat_1 chromatin 12_52013974_A_C 595 PPP1CC_3 1012_Vorinostat_1 chromatin 10_11921140_T_G / 1_185150475_G_A / 11_124896232_A_G 596 SYDE1_2 179_5-Fluorouracil_1 DNArep 11_65547388_T_G / 13_113159942_A_G 597 C11orf74_2 294_MPS-1-IN-1_3 mitosis 12_124473081_C_T / 19_17205202_T_G 598 NEFH_1 294_MPS-1-IN-1_3 mitosis 16_55415_T_G 599 MPPE1_2 294_MPS-1-IN-1_3 mitosis 1_160801918_G_C / 6_10410133_T_G 600 RAC3_1 281_Alectinib_2 rtk 20_42084724_T_C 601 XRCC2_1 1011_Navitoclax_2 apop 2_219297298_T_G 602 PVRL2_2 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 11_12162199_T_G 603 JAKMIP1_3 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 16_1817242_T_C / 6_33279455_T_G 604 RETSAT_2 305_TPCA-1_3 other 1_113900413_C_G / 10_43200831_A_G 605 ECSIT_4 1012_Vorinostat_1 chromatin 19_4911043_A_C / 2_60761746_T_G / 11_43920052_A_C / 12_6818898_A_C 606 KCTD11_5 263_FR-180204_3 erk_mapk 11_65547388_T_G / 14_93183653_A_C / 13_113159942_A_G / 1_54243266_A_G / 17_7797836_A_C 607 NOL4_1 294_MPS-1-IN-1_3 mitosis 16_30953637_A_C 608 PHACTR3_1 294_MPS-1-IN-1_3 mitosis 16_30953637_A_C 609 RTN1_1 294_MPS-1-IN-1_3 mitosis 16_30953637_A_C 610 STMN2_1 294_MPS-1-IN-1_3 mitosis 16_30953637_A_C 611 AP2S1_2 304_SB52334_3 rtk 2_61492168_C_A / 2_27774175_G_T 612 ZFYVE21_1 179_5-Fluorouracil_1 DNArep 22_42212334_A_C 613 UNC13A_1 1026_Tanespimycin_2 other 2_105307612_A_C 614 HRH3_2 294_MPS-1-IN-1_3 mitosis 3_128945112_G_A / 6_33279455_T_G 615 SLC46A3_1 275_I-BET-762_3 chromatin 11_12162199_T_G 616 FANCF_1 226_GSK1070916_2 mitosis 2_61492168_C_A 617 NUP188_1 1011_Navitoclax_2 apop 17_73203001_T_G 618 RASL11B_4 294_MPS-1-IN-1_3 mitosis 5_181155466_T_G / 11_73355795_A_G / 1_220067324_T_G / 9_126483890_T_G 619 RPL35A_1 253_XMD14-99_3 rtk 1_145961089_T_G 620 MRPS34_2 263_FR-180204_3 erk_mapk 6_32035203_A_C / 22_22098988_G_T 621 GIMAP2_3 179_5-Fluorouracil_1 DNArep 1_155709773_T_G / 16_87644643_G_A / 12_51745916_T_G 622 CEP290_2 305_TPCA-1_3 other 15_65451964_A_G / 12_57062993_T_G 623 GLTPD1_2 300_CX-5461_3 other 1_44339331_A_G / 9_37887606_C_T 624 GPHN_2 294_MPS-1-IN-1_3 mitosis 11_12162199_T_G / 13_39724512_C_T 625 CASP1_1 294_MPS-1-IN-1_3 mitosis 12_40313960_G_T 626 ZNF696_1 294_MPS-1-IN-1_3 mitosis 12_40313960_G_T 627 PUM2_1 294_MPS-1-IN-1_3 mitosis 19_3281403_A_C 628 MEIS1_3 179_5-Fluorouracil_1 DNArep 13_113159942_A_G / 17_36608462_A_C / 16_29836801_T_G 629 IFI30_1 269_NSC-207895_3 p53 16_55415_T_G 630 IL11RA_1 1012_Vorinostat_1 chromatin 10_11921140_T_G 631 NUCB2_1 1012_Vorinostat_1 chromatin 10_11921140_T_G 632 PTP4A3_1 1012_Vorinostat_1 chromatin 10_11921140_T_G 633 ADRBK2_2 294_MPS-1-IN-1_3 mitosis 11_65547388_T_G / 17_78476773_C_T 634 PKIG_3 156_AZD6482_2 pi3k 10_47523038_G_A / 10_46337735_A_G / 2_105307612_A_C 635 SET_2 1011_Navitoclax_2 apop 2_113934259_C_T / 7_44964464_T_C 636 FLII_4 294_MPS-1-IN-1_3 mitosis 12_51745916_T_G / 1_213007133_T_G / 16_1342948_A_C / 2_86027990_C_A 637 ARF6_1 300_CX-5461_3 other 1_173850301_T_G 638 HMGCR_1 294_MPS-1-IN-1_3 mitosis 16_1817242_T_C 639 ST8SIA3_1 294_MPS-1-IN-1_3 mitosis 16_1817242_T_C 640 UNC80_1 294_MPS-1-IN-1_3 mitosis 16_1817242_T_C 641 CCT8_3 1012_Vorinostat_1 chromatin 7_108024001_C_T / 8_61583890_T_A / 7_108023984_G_A 642 TRIM28_1 1012_Vorinostat_1 chromatin 19_40695973_T_G 643 CDC25A_2 1011_Navitoclax_2 apop 19_9566733_T_G / 14_55169342_TAAA_T 644 GLTP_2 1012_Vorinostat_1 chromatin 2_61492168_C_A / 1_149852603_A_G 645 CCDC77_1 1012_Vorinostat_1 chromatin 7_108023984_G_A 646 MCF2L_1 1091_BMS-536924_3 igfr 15_43578884_A_G 647 SLC6A2_2 294_MPS-1-IN-1_3 mitosis 16_1817242_T_C / 13_113159942_A_G 648 SYP_2 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 16_1817242_T_C 649 CNOT6_1 1012_Vorinostat_1 chromatin 15_75524142_T_C 650 VARS_1 1012_Vorinostat_1 chromatin 15_75524142_T_C 651 IFITM3_4 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 16_1817242_T_C / 7_149253814_T_G / 8_27431326_A_G 652 PEX5_1 1091_BMS-536924_3 igfr 2_96842345_G_C 653 SLC31A2_2 196_Phenformin_3 metabol 2_171833908_C_T / 2_171744206_C_A 654 GRIK3_1 294_MPS-1-IN-1_3 mitosis 3_128945112_G_A 655 VN1R1_1 294_MPS-1-IN-1_3 mitosis 1_213007133_T_G 656 TFB2M_1 1012_Vorinostat_1 chromatin 6_32002466_A_C 657 MAD2L1_1 1011_Navitoclax_2 apop 19_9566733_T_G 658 MCM7_1 1011_Navitoclax_2 apop 19_9566733_T_G 659 MLF1IP_1 1011_Navitoclax_2 apop 19_9566733_T_G 660 RFC3_1 1011_Navitoclax_2 apop 19_9566733_T_G 661 RPL13A_5 1012_Vorinostat_1 chromatin 4_145127510_C_T / 12_57470756_A_G / 15_45095024_A_C / 19_44985182_T_G / 20_47227145_T_G 662 LINGO2_5 221_TAK-715_2 jnk_p38 12_51745916_T_G / 17_737856_G_T / 10_74988957_T_G / 3_113344632_A_C / 4_173528913_A_G 663 DNAJC22_1 1011_Navitoclax_2 apop 15_75268724_T_G 664 LAPTM4B_5 1012_Vorinostat_1 chromatin 13_19425701_C_A / 7_117129719_T_G / 2_131597280_C_G / 1_54243276_T_G / 20_34850996_A_C 665 MRPL21_1 1012_Vorinostat_1 chromatin 22_22098988_G_T 666 KBTBD6_5 304_SB52334_3 rtk 11_65547388_T_G / 5_141478412_T_C / 13_113159942_A_G / 2_108507561_T_G / 6_30705792_T_G 667 ENDOD1_1 1012_Vorinostat_1 chromatin 5_80744593_A_C 668 DYNLT3_1 1012_Vorinostat_1 chromatin 16_70661204_T_G 669 FBXO33_3 253_XMD14-99_3 rtk 6_25488355_C_T / 6_25510468_CAT_C / 4_144114635_G_A 670 MAGT1_3 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 6_29631350_A_G / 10_11921140_T_G 671 RAP2C_1 253_XMD14-99_3 rtk 19_4911043_A_C 672 UNC13A_4 294_MPS-1-IN-1_3 mitosis 6_37282313_A_C / 16_1817242_T_C / 10_11921140_T_G / 13_113159942_A_G 673 MFAP5_1 150_Bicalutamide_1 other 9_18775833_A_C 674 CUX2_2 294_MPS-1-IN-1_3 mitosis 11_12162199_T_G / 8_122952205_T_G 675 MED25_5 1012_Vorinostat_1 chromatin 17_18282776_T_G / 11_74492398_A_C / 19_1460944_T_G / 1_224418353_A_C / X_54813054_T_G 676 MYT1L_2 294_MPS-1-IN-1_3 mitosis 16_1817242_T_C / 15_43211582_A_C 677 TMEM18_2 176_IPA-3_3 cytoskeleton 2_54968084_G_A / 2_55027029_T_A 678 CCT7_1 1012_Vorinostat_1 chromatin 12_40313960_G_T 679 MAK16_1 1012_Vorinostat_1 chromatin 12_40313960_G_T 680 MRPS21_1 1012_Vorinostat_1 chromatin 12_40313960_G_T 681 POLR1B_1 1012_Vorinostat_1 chromatin 12_40313960_G_T 682 GTPBP1_2 333_T0901317_3 other 9_37887606_C_T / 11_43920052_A_C 683 EBF3_1 294_MPS-1-IN-1_3 mitosis 9_5549463_A_C 684 MTUS1_2 1012_Vorinostat_1 chromatin 19_53998273_G_A / 19_53999532_G_A 685 NUP133_2 179_5-Fluorouracil_1 DNArep 10_11921140_T_G / 11_12162199_T_G 686 CTNND1_2 294_MPS-1-IN-1_3 mitosis 6_30705800_T_G / 9_69516199_A_C 687 NDUFB9_1 1012_Vorinostat_1 chromatin 19_4911043_A_C 688 SLC9A7_1 1012_Vorinostat_1 chromatin 19_4911043_A_C 689 EIF4ENIF1_1 1091_BMS-536924_3 igfr 9_37887606_C_T 690 DOCK1_1 196_Phenformin_3 metabol 8_94407470_A_G 691 RPL32_1 300_CX-5461_3 other 8_12430448_C_T 692 PRICKLE2_1 185_Linsitinib_2 igfr 11_65547388_T_G 693 RUFY3_1 185_Linsitinib_2 igfr 11_65547388_T_G 694 WNT5A_1 185_Linsitinib_2 igfr 11_65547388_T_G 695 MPHOSPH10_2 275_I-BET-762_3 chromatin 15_75524142_T_C / 12_40313960_G_T 696 ARID3A_1 344_THZ-2-49_3 cell_cyc 8_7290003_A_C 697 HBQ1_1 344_THZ-2-49_3 cell_cyc 8_7290003_A_C 698 CAPG_5 305_TPCA-1_3 other 11_12162199_T_G / 10_11921140_T_G / 20_45938939_T_G / 1_156286332_T_G / 15_75783033_T_G 699 YARS2_2 1012_Vorinostat_1 chromatin 4_41632760_G_C / 4_41631305_C_A 700 KIAA0247_5 269_NSC-207895_3 p53 1_149852603_A_G / 17_55774876_T_G / 16_18379704_T_G / 7_114630022_T_G / 19_15191478_T_G 701 ATP6V1A_1 1012_Vorinostat_1 chromatin 9_69516199_A_C 702 NFXL1_3 179_5-Fluorouracil_1 DNArep 17_55774876_T_G / 1_228244520_T_G / 20_16044565_T_G 703 RIOK3_3 293_Amuvatinib_2 rtk 2_61492168_C_A / 19_4679822_A_C / 1_1918305_G_A 704 AKR7A2_4 281_Alectinib_2 rtk 1_213007133_T_G / 17_55774876_T_G / 17_15651252_T_G / 1_451649_A_AG 705 THOC1_3 305_TPCA-1_3 other 1_44804312_T_G / 17_5474687_A_C / 8_68625531_T_G 706 COPG_1 1026_Tanespimycin_2 other 6_26897081_G_C 707 RPL13_1 185_Linsitinib_2 igfr 20_42084724_T_C 708 ARRB2_2 179_5-Fluorouracil_1 DNArep 2_170965958_A_C / 20_33848655_A_C 709 CCDC41_2 269_NSC-207895_3 p53 9_86322936_ATTT_A / 9_86345023_C_T 710 WDR75_5 1012_Vorinostat_1 chromatin 3_196782572_G_T / 1_154331414_T_G / 7_149253814_T_G / 2_190469793_G_C / 18_14183954_G_T 711 LRBA_4 1011_Navitoclax_2 apop 13_114236659_T_G / 11_65547388_T_G / 2_178769713_G_T / 13_113159942_A_G 712 BAI3_2 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 6_30705792_T_G 713 FKBP4_1 1012_Vorinostat_1 chromatin 13_113325635_A_G 714 H3F3B_1 1012_Vorinostat_1 chromatin 13_113325635_A_G 715 LRRC45_1 281_Alectinib_2 rtk 17_6118065_A_G 716 VPRBP_1 1011_Navitoclax_2 apop 3_128945112_G_A 717 KIF1A_1 294_MPS-1-IN-1_3 mitosis 9_69516199_A_C 718 RPL3_1 294_MPS-1-IN-1_3 mitosis 2_24067801_G_A 719 ABI3BP_1 1012_Vorinostat_1 chromatin 16_87644643_G_A 720 FBRSL1_1 1091_BMS-536924_3 igfr 10_11921140_T_G 721 RAB3C_1 294_MPS-1-IN-1_3 mitosis 10_11921140_T_G 722 C16orf59_1 1012_Vorinostat_1 chromatin 19_9566733_T_G 723 NUP35_1 263_FR-180204_3 erk_mapk 19_9566733_T_G 724 LPIN2_1 344_THZ-2-49_3 cell_cyc 3_191357867_G_A 725 ZNF507_2 305_TPCA-1_3 other 11_65547388_T_G / 17_55774876_T_G 726 ADAM10_1 344_THZ-2-49_3 cell_cyc 17_63963708_T_C 727 FBXL18_1 344_THZ-2-49_3 cell_cyc 17_63963708_T_C 728 TMOD3_1 344_THZ-2-49_3 cell_cyc 17_63963708_T_C 729 HLCS_3 263_FR-180204_3 erk_mapk 14_67381608_G_T / 15_84241166_A_C / 17_43922689_A_G 730 NYNRIN_1 293_Amuvatinib_2 rtk 10_11921140_T_G 731 PDXK_1 344_THZ-2-49_3 cell_cyc 16_72164743_G_A 732 RPS11_3 1012_Vorinostat_1 chromatin 4_145127510_C_T / 17_28613683_A_C / 8_12430448_C_T 733 LCE2B_1 94_TGX221_3 pi3k 10_133753622_G_A 734 MAP2K7_3 1012_Vorinostat_1 chromatin 1_11243090_T_G / 12_109952676_A_C / 21_46245172_A_C 735 PATZ1_1 1012_Vorinostat_1 chromatin 11_12162199_T_G 736 SMCR7L_1 1012_Vorinostat_1 chromatin 11_12162199_T_G 737 CNTNAP2_1 196_Phenformin_3 metabol 8_7290003_A_C 738 SLC29A3_1 196_Phenformin_3 metabol 8_7290003_A_C 739 ZBTB34_1 185_Linsitinib_2 igfr 3_165019547_G_T 740 PRKAA1_2 294_MPS-1-IN-1_3 mitosis X_100585180_G_T / 3_128945112_G_A 741 IRF1_2 294_MPS-1-IN-1_3 mitosis 17_55774876_T_G / 12_51745916_T_G 742 GDAP1L1_5 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 16_1817242_T_C / 11_125626705_T_G / 9_128835995_A_C / 7_20404680_T_G 743 NUP205_2 290_KIN001-260_3 other 15_78476214_A_G / 10_19491534_C_A 744 NUS1_1 1011_Navitoclax_2 apop 1_147618935_T_C 745 GOLT1B_3 344_THZ-2-49_3 cell_cyc 16_72119226_C_G / 16_72129067_G_T / 16_72164743_G_A 746 SEC24A_2 1026_Tanespimycin_2 other 15_28382572_T_C / 7_5308283_G_A 747 AVEN_1 94_TGX221_3 pi3k 7_75422659_A_G 748 BRD3_1 1011_Navitoclax_2 apop 2_113934259_C_T 749 CBX5_1 1011_Navitoclax_2 apop 2_113934259_C_T 750 ZNF689_1 1012_Vorinostat_1 chromatin 3_53183591_A_C 751 RHOG_5 1194_SB-505124_3 other 5_427675_T_C / 16_1817242_T_C / 13_113159942_A_G / 16_30398066_C_A / 2_121418676_T_G 752 SPRY1_4 224_AS605240_3 pi3k 3_121642799_G_A / 3_121634481_A_C / 3_121699918_T_C / 3_121642940_G_A 753 NR1H2_2 1011_Navitoclax_2 apop 1_154627925_A_C / 1_150261398_T_G 754 RTKN2_1 294_MPS-1-IN-1_3 mitosis 6_73644452_C_T 755 CHRNA5_1 294_MPS-1-IN-1_3 mitosis 6_10410133_T_G 756 PEBP1_1 1011_Navitoclax_2 apop 4_108762737_T_G 757 CNOT6_1 196_Phenformin_3 metabol 1_16589114_C_T 758 FEM1B_1 263_FR-180204_3 erk_mapk 1_151048750_A_C 759 PDCD2L_1 151_QS11_3 other 2_196880031_T_C 760 BCCIP_2 1012_Vorinostat_1 chromatin 1_219979389_T_A / 19_11402175_A_C 761 C17orf80_2 344_THZ-2-49_3 cell_cyc 16_72119226_C_G / 16_72129067_G_T 762 TMEM229A_1 1012_Vorinostat_1 chromatin 6_30705792_T_G 763 AKAP1_1 344_THZ-2-49_3 cell_cyc 16_72119226_C_G 764 EPC2_1 344_THZ-2-49_3 cell_cyc 16_72119226_C_G 765 FKBP14_1 344_THZ-2-49_3 cell_cyc 16_72119226_C_G 766 HMGB1_1 344_THZ-2-49_3 cell_cyc 16_72119226_C_G 767 TMEM167B_1 344_THZ-2-49_3 cell_cyc 16_72119226_C_G 768 FURIN_1 281_Alectinib_2 rtk 2_113934259_C_T 769 FUZ_2 1012_Vorinostat_1 chromatin 10_73803641_A_G / 17_6118065_A_G 770 RAX_1 94_TGX221_3 pi3k 14_64951601_A_C 771 HSPA5_1 344_THZ-2-49_3 cell_cyc 1_165652085_TATTATC_T 772 SEZ6_1 294_MPS-1-IN-1_3 mitosis 3_128879626_CGT_C 773 CDC7_2 1011_Navitoclax_2 apop 6_73622013_G_C / 6_73635330_C_T 774 TIMELESS_2 1011_Navitoclax_2 apop 2_218827668_A_C / 20_48700966_A_C 775 FAIM2_1 294_MPS-1-IN-1_3 mitosis 3_127621040_A_G 776 PKIA_1 275_I-BET-762_3 chromatin 13_113159942_A_G 777 MRFAP1L1_1 304_SB52334_3 rtk 11_12162199_T_G 778 SLC4A8_1 1011_Navitoclax_2 apop 6_33296240_C_A 779 SAMM50_1 344_THZ-2-49_3 cell_cyc 17_76009153_A_C 780 FAM129A_1 263_FR-180204_3 erk_mapk 13_113159942_A_G 781 AFMID_5 1012_Vorinostat_1 chromatin 14_70800628_C_T / 12_6941768_C_A / 11_12162199_T_G / 3_119147558_G_A / 3_196782572_G_T 782 STARD7_1 344_THZ-2-49_3 cell_cyc 21_31701881_A_G 783 GPN2_2 300_CX-5461_3 other 17_55774876_T_G / 1_451649_A_AG 784 PCDH9_1 344_THZ-2-49_3 cell_cyc 3_75669056_G_A 785 DDOST_2 344_THZ-2-49_3 cell_cyc 1_16589114_C_T / 6_10398408_A_G 786 TMEM109_3 179_5-Fluorouracil_1 DNArep 13_113159942_A_G / 16_30398066_C_A / 5_141102658_A_C 787 OLA1_2 196_Phenformin_3 metabol 1_148117837_C_T / 1_146969331_G_A 788 RGS3_4 344_THZ-2-49_3 cell_cyc 2_241748788_C_T / 2_241748877_C_T / 2_241751260_G_A / 2_241744700_T_C 789 HMGCL_1 344_THZ-2-49_3 cell_cyc 1_16589114_C_T 790 SIPA1L1_1 344_THZ-2-49_3 cell_cyc 1_16589114_C_T 791 TMEM50A_1 344_THZ-2-49_3 cell_cyc 1_16589114_C_T 792 AP2S1_2 196_Phenformin_3 metabol 7_100951952_T_A / 7_100951953_T_A 793 NARF_1 304_SB52334_3 rtk 5_83553308_T_G 794 S100A2_2 1011_Navitoclax_2 apop 11_65547388_T_G / 17_55774876_T_G 795 STX8_2 94_TGX221_3 pi3k 7_100951952_T_A / 7_100951953_T_A 796 SLC10A4_3 1011_Navitoclax_2 apop 6_30329265_T_C / 16_1817242_T_C / 12_51745916_T_G 797 KCNAB1_1 294_MPS-1-IN-1_3 mitosis 19_17205202_T_G 798 NUFIP1_1 294_MPS-1-IN-1_3 mitosis 1_112520503_A_G 799 PUS7_1 1011_Navitoclax_2 apop 11_65547388_T_G 800 TMEM33_1 1011_Navitoclax_2 apop 11_65547388_T_G 801 SUPT4H1_1 281_Alectinib_2 rtk 1_247949628_T_C 802 B4GALT1_2 185_Linsitinib_2 igfr 13_113159942_A_G / 11_65547388_T_G 803 TRMT1_1 344_THZ-2-49_3 cell_cyc 12_8176004_A_C 804 ITCH_1 344_THZ-2-49_3 cell_cyc 1_13281477_A_G 805 SLC41A2_1 1527_Pictilisib_2 pi3k 4_118640836_A_T 806 UBXN1_1 1091_BMS-536924_3 igfr 10_73803641_A_G 807 AARS2_1 293_Amuvatinib_2 rtk 2_211420614_AAAAG_A 808 ASB13_1 1012_Vorinostat_1 chromatin 17_28613683_A_C 809 CSDA_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G 810 DBH_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G 811 DOK4_1 185_Linsitinib_2 igfr 13_113159942_A_G 812 FAM57B_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G 813 GRIA4_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G 814 IGFBPL1_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G 815 NFKBIZ_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G 816 PIEZO1_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G 817 SCN3B_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G 818 SNAP91_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G 819 TMEM151B_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G 820 TRAM1_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G 821 DLGAP2_1 294_MPS-1-IN-1_3 mitosis 6_33279455_T_G 822 GFRA2_2 1011_Navitoclax_2 apop 5_38950065_A_T / 16_30953637_A_C 823 C12orf44_5 1011_Navitoclax_2 apop 8_72935904_A_T / 8_23202743_T_C / 15_40296801_A_G / 8_23201811_C_G / 9_134768529_A_G 824 CPD_2 1091_BMS-536924_3 igfr 16_30953637_A_C / 9_108900415_C_A 825 UNG_3 1011_Navitoclax_2 apop 7_108023984_G_A / 4_70722781_C_T / 3_52437514_T_G 826 AGAP2_1 263_FR-180204_3 erk_mapk 10_77108446_G_A 827 DPY19L4_1 294_MPS-1-IN-1_3 mitosis 7_149253814_T_G 828 UST_1 294_MPS-1-IN-1_3 mitosis 4_70722781_C_T 829 MAP2K7_1 344_THZ-2-49_3 cell_cyc 1_16734496_C_T 830 DLG1_1 344_THZ-2-49_3 cell_cyc 3_197683305_A_C 831 MAPK8IP2_1 185_Linsitinib_2 igfr 6_25669441_G_A 832 TARDBP_3 1011_Navitoclax_2 apop 11_65547388_T_G / 22_42212334_A_C / 15_65451964_A_G 833 CYLD_1 294_MPS-1-IN-1_3 mitosis 17_40348252_T_G 834 ATL2_1 294_MPS-1-IN-1_3 mitosis 3_38112112_T_G 835 SCAMP5_1 294_MPS-1-IN-1_3 mitosis X_100585180_G_T 836 ARL6IP5_1 196_Phenformin_3 metabol 14_102870248_A_C 837 TUBD1_1 276_CAY10603_3 chromatin 1_161021085_T_C 838 OLFM3_1 294_MPS-1-IN-1_3 mitosis 10_43200831_A_G 839 ODC1_2 310_YM201636_3 other 1_44339337_G_A / 15_75524142_T_C 840 EXOSC8_4 1011_Navitoclax_2 apop 6_73622013_G_C / 6_73635330_C_T / 2_127651579_A_C / 6_30705792_T_G 841 GEMIN5_4 1012_Vorinostat_1 chromatin 9_104837455_A_G / 8_42401781_A_G / 1_46261223_G_A / 15_72662708_A_C 842 BCLAF1_1 269_NSC-207895_3 p53 11_65547388_T_G 843 ADAMTSL2_3 294_MPS-1-IN-1_3 mitosis 14_20996722_T_G / 8_122952205_T_G / 9_136745293_A_C 844 GSDMD_1 196_Phenformin_3 metabol 8_143559981_G_GAGGGCAGGGC 845 FILIP1L_1 344_THZ-2-49_3 cell_cyc 2_117977926_TAGTC_T 846 MPP5_1 344_THZ-2-49_3 cell_cyc 16_10941900_CGAA_C 847 ZNF781_2 1011_Navitoclax_2 apop 6_30705792_T_G / 11_65547388_T_G 848 GREB1_1 294_MPS-1-IN-1_3 mitosis 11_65547388_T_G 849 MICAL2_1 294_MPS-1-IN-1_3 mitosis 11_65547388_T_G 850 MLKL_1 304_SB52334_3 rtk 17_55774876_T_G 851 HIATL1_1 333_T0901317_3 other 1_13816508_A_G 852 POFUT2_3 344_THZ-2-49_3 cell_cyc 16_72119226_C_G / 16_72164743_G_A / 7_95495738_CT_C 853 FSD1L_3 1011_Navitoclax_2 apop 13_113159942_A_G / 11_12162199_T_G / 11_65547388_T_G 854 SLC22A4_1 294_MPS-1-IN-1_3 mitosis 2_60761746_T_G 855 ECE1_1 344_THZ-2-49_3 cell_cyc 3_196484004_T_C 856 FAM120C_1 179_5-Fluorouracil_1 DNArep 1_206458298_T_G 857 WDR18_1 1012_Vorinostat_1 chromatin 1_64663808_A_C 858 SPAST_2 305_TPCA-1_3 other 14_68291858_T_C / 4_158607939_A_AT 859 RIN2_1 344_THZ-2-49_3 cell_cyc 2_15474280_T_C 860 RUNX2_2 185_Linsitinib_2 igfr 11_12162199_T_G / 15_75268724_T_G 861 NOP14_2 1012_Vorinostat_1 chromatin 17_3513849_GCA_G / 9_36058818_G_T 862 MAN2B2_1 1012_Vorinostat_1 chromatin 17_55774876_T_G 863 PAIP1_1 344_THZ-2-49_3 cell_cyc 1_112659795_G_A 864 DHX32_2 344_THZ-2-49_3 cell_cyc X_119469587_A_G / X_119451980_A_G 865 PLK2_2 344_THZ-2-49_3 cell_cyc 3_9688859_C_T / 5_127331576_G_A 866 PRCC_1 1012_Vorinostat_1 chromatin 4_9908299_G_A 867 XAF1_1 344_THZ-2-49_3 cell_cyc 2_197498780_A_G 868 METAP2_1 344_THZ-2-49_3 cell_cyc 2_208237181_GA_G 869 CLK2_1 294_MPS-1-IN-1_3 mitosis 2_230875561_A_G 870 DPP6_1 294_MPS-1-IN-1_3 mitosis 19_43375573_G_T 871 ACSL4_3 344_THZ-2-49_3 cell_cyc 11_33583339_C_T / 11_33583414_C_T / 11_33606557_T_G 872 ANKIB1_1 1012_Vorinostat_1 chromatin 2_218827668_A_C 873 MRPL44_1 263_FR-180204_3 erk_mapk 10_11921140_T_G 874 ECSIT_1 344_THZ-2-49_3 cell_cyc 2_105307612_A_C 875 UTRN_1 344_THZ-2-49_3 cell_cyc 2_105307612_A_C 876 KLHL3_1 94_TGX221_3 pi3k 3_10062127_TA_T 877 PPP3CC_1 1011_Navitoclax_2 apop 15_77916965_T_C 878 ZNF146_2 276_CAY10603_3 chromatin 13_113159942_A_G / 3_196782572_G_T 879 ZNF561_1 156_AZD6482_2 pi3k 2_9954863_A_G 880 GABRB3_2 196_Phenformin_3 metabol 2_15474280_T_C / 2_15534562_T_C 881 FUCA2_2 294_MPS-1-IN-1_3 mitosis 1_185150475_G_A / X_54813054_T_G 882 ZNF704_1 196_Phenformin_3 metabol 11_120836935_C_T 883 RSRC2_1 179_5-Fluorouracil_1 DNArep 11_43920052_A_C 884 ZNF786_4 1166_QL-VIII-58_3 tor 16_72119226_C_G / 16_72164743_G_A / 16_72129067_G_T / 16_72150667_C_T 885 FAM208A_4 344_THZ-2-49_3 cell_cyc 1_103021838_CT_C / 8_7290003_A_C / 1_103002059_C_T / 1_102989661_C_T 886 KLC1_2 179_5-Fluorouracil_1 DNArep 6_30705792_T_G / 9_35801627_T_G 887 C4orf46_1 1011_Navitoclax_2 apop 1_44804312_T_G 888 PFDN2_1 1012_Vorinostat_1 chromatin 1_200988322_T_G 889 TMEM88_1 304_SB52334_3 rtk 15_63286530_C_T 890 CAMKMT_1 1009_Tretinoin_1 other 3_165019547_G_T 891 RAB3A_5 1091_BMS-536924_3 igfr 1_149852603_A_G / 15_75293000_T_G / 16_15664675_G_T / 1_150261398_T_G / 13_113325635_A_G 892 PPP1R3C_1 1012_Vorinostat_1 chromatin 1_172308705_AT_A 893 RNPS1_1 1012_Vorinostat_1 chromatin 6_26033581_T_TAAG 894 SESN1_1 185_Linsitinib_2 igfr 8_93815432_A_C

Results of verification of biomarker responsiveness to brain tumor drugs No. FRH Var_Exp (pval) Var_Drug (pval) Exp_Drug (pval) Ave_VarDrug (pval) Rank One PTRF_9 2.02E-17 0.000749693 / 0.000426098 / 0.009328967 / 0.000372589 / 0.006511221 / 2.35E-11 / 0.000116605 / 0.001047505 / 0.001374062 / 0.001565845 / 0.006047479 / 7.32E-05 / 0.006557575 / 9.01E-05 / 0.000574879 / 0.000160684 / 2.49E-05 / 0.002310424 / 0.000331474 0.000819278 / 9.28E-12 / 0.002957218 / 0.007844904 / 0.002619813 / 0.000685764 / 3.28E-05 / 0.007149858 / 1.82E-05 / 0.004659546 / 0.004062417 / 0.000187819 / 2.07E-07 / 0.004167431 / 0.001265165 / 0.002575563 / 0.000839515 / 0.008965476 / 0.00033059 4.72E-05 / 0.001888735 / 0.00646848 / 0.000714169 / 2.80E-07 / 0.001294695 / 0.000115716 / 3.08E-06 / 0.000261232 / 0.001910231 / 1.28E-06 / 0.004145356 / 0.003060428 / 0.006977625 / 0.001419304 / 7.63E-09 / 0.009439533 / 0.003871906 / 0.00072755 / 3.06E-06 / 0.003623857 / 0.001340666 / 0.008077047 / 0.000197417 / 0.003726859 / 0.001744921 / 0.006814012 / 0.007768596 / 0.001018135 8.86E-05 / 0.015861427 / 0.000935884 / 6.69E-06 / 0.001642604 / 7.15E-09 / 0.000114128 / 0.005567682 / 0.001713376 / 0.003771243 / 0.001845691 / 6.63E-05 / 0.000313526 / 0.002067719 / 0.000456029 / 0.003684593 / 5.74E-06 / 0.002204168 / 0.000228633 / 0.000400518 / 6.03E-07 / 0.000743512 / 0.012226314 / 0.024250323 / 8.17E-07 / 0.000107275 / 0.068108214 / 1.05E-05 / 0.245827021 / 0.000690655 / 0.00029549 / 3.30E-06 / 0.000963538 / 0.000798032 / 0.000737892 / 0.005284786 / 0.00534 / 8.80E-05 / 0.004403153 / 0.004222642 / 0.006563798 / 0.000101882 / 5.52E-08 / 0.000895926 / 4.32E-06 / 2.39E-05 / 0.012076982 / 0.000700794 / 4.02E-08 / 0.000551546 / 0.005498224 / 0.005843004 / 0.004771885 / 7.03E -09 / 0.000449732 / 0.00773881 / 0.00481047 / 2.17E-06 / 0.029515032 / 2.54E-05 / 0.001228246 / 0.001095519 / 0.018900662 / 0.000306042 / 1.61E-05 / 0.007260065 / 0.036785468 0.00244 67 2 MBTD1_5 0.0000000000 6.079058529181583e-06 / 0.000330234961590499 / 0.0009065836837091153 / 7.743250099097525e-08 / 5.4243318683013945e-06 / 6.638871076180972e-05 / 0.0001034540386175869 / 2.742943691390761e-05 / 8.864763064813537e-07 / 2.0409106 / 0.001580303435076526 / 0.00012171542819902834 2.8823341263186404e-09 / 7.828409458693464e-09 / 8.294895004123309e-09 / 3.2262810582910645e-08 / 1.8139300001511646e-07 / 1.8402518116440838e-07 / 2.67841045277985e-07 / 1.5039088850140218e-06 / 1.3222940844102726e-06924 0.00019219761010832952 / 8.314417317729093e-07 / 1.370078882045095e-05 / 6.768156840167973e-06 / 1.0455349186526601e-05 / 2.2476152083519155e-06 / 3.022593119181365e-06 0.000545 17 3 C12orf29_4 0.0000000000 4.824002117845577e-08 / 0.005441831791967279 / 1.1897498080889868e-05 / 2.832726371483715e-06 / 3.554190719208408e-05 / 9.98122338478244e-05 / 0.00019780761336601855 / 1.2166594948453657e-06 / 0.0013399032530365647 / 0.010366551109197954 9.831623775837906e-08 / 1.1424232521759333e-06 / 4.317636814226818e-05 / 1.4382106269639384e-06 / 1.565031148370116e-06 / 0.0001061775620019226 / 7.880009857538694e-07 / 5.059091238516106e-06 / 6.9124096914811e-05 / 3.74550652948 0.00175 10 4 DDX20_1 0.0000010604 9.390951294242489e-05 / 0.003291125326808141 / 6.606509042863372e-05 / 0.0009706006123489501 / 0.00033173858745018413 / 2.8301251379202592e-05 / 0.002989009151291833 / 0.0003464118358647972 / 4.611763366846969e-05 / 0.010271987936204268 1.8690130781974698e-08 / 1.7049356788275527e-06 / 4.90739703689557e-07 / 2.1664146971003018e-07 / 2.2579476817862133e-07 / 2.2223004763773554e-07 / 1.487681859612425e-06 / 5.806089896300099e-06 / 5.518438170954557e5707 0.001844 10 5 TACC1_4 0.0000000000 3.87018819160593e-07 / 7.839796663490128e-06 / 0.0211517389620851 / 0.0007385583772737821 / 0.0001541124146376614 / 0.000740753187661269 / 0.00010956462066226552 / 0.0005066082079176534 / 0.00031180764933246263 / 0.0002656005692813481 1.8794101118497154e-10 / 5.932840218364882e-08 / 1.3308222183335375e-05 / 3.6611240087061e-07 / 1.9891885346261133e-06 / 2.780203755383467e-06 / 7.920522224234305e-06 / 4.233437731609824e-05 / 1.3783248323482445e-06 / 8.7150024158 0.002399 10 6 SFPQ_1 0.0000000779 4.611763366846969e-05 / 6.606509042863372e-05 / 9.390951294242489e-05 / 0.0021892065422244767 / 0.002989009151291833 / 2.8301251379202592e-05 / 0.006770110957154303 / 0.003291125326808141 / 0.00018869114988485987 / 0.023379270483941148 1.6421685468372866e-11 / 2.7347777767986492e-08 / 6.012098925210058e-08 / 2.202165084592466e-05 / 9.663054308166113e-05 / 8.127505856380939e-07 / 1.0837751787086504e-05 / 8.284871105188379e-05 / 1.8339230937241138e-06 / 7.70485657 0.003904 10 7 LRPPRC_2 0.0000000013 1.2022019578742027e-05 / 0.0003761548279529811 / 0.0037244088642669265 / 0.0021708592883619747 / 0.0001663224278721914 / 0.023108708224531857 / 2.9430765473148166e-05 / 0.01050357293743899 / 0.020115537840238746 / 0.010524107924498233 5.209483330257566e-10 / 8.01050796462614e-08 / 2.4695473842016646e-07 / 8.371111187295495e-08 / 5.106669850809745e-07 / 4.686091200519956e-06 / 1.3349886552198077e-08 / 1.915969698573113e-06 / 2.9107217405524718e-0697 2.599767 0.007073 10 8 ILF3_5 0.0000000000 1.3887956173777372e-05 / 1.6939519588941488e-05 / 9.786382578515826e-08 / 0.0007340541171379744 / 3.1279199929494124e-06 / 9.697231213241931e-06 / 0.0003946275449128456 / 0.0013987772568790748 / 0.0011249003808451194 1.7515743716180326e-07 / 3.0845658986771253e-07 / 6.542843309537432e-09 / 1.1331609020935322e-06 / 4.268164739909969e-07 / 1.315856013252508e-05 / 7.875046335838071e-06 / 4.114385321933064e-07 / 2.3594761771202245e-05 0.000411 9 9 ATXN7L3B_5 0.0000000000 2.612066597760477e-06 / 0.00011479613384953161 / 7.334368900690378e-11 / 0.0010577852528073678 / 9.018479144369487e-06 / 9.409687610838478e-05 / 0.003583481340909988 / 1.7599872572764645e-05 / 0.0008387169638839557 2.969448250016487e-08 / 1.9600165258234536e-07 / 4.2990302404127387e-08 / 2.1159749013263597e-06 / 1.0277412362510468e-05 / 2.2327592321063564e-05 / 2.749246019785697e-06 / 2.702131319979186e-05 / 6.193347041468136e06 0.000635 9 10 CENPV_1 0.0000001156 0.006820424547488444 / 1.2412020538304333e-05 / 0.004148676908553548 / 0.005770181686062503 / 0.019668015814206605 / 0.0025299472548494955 / 0.005078710464709388 / 0.0004338260851758113 / 0.03879612345050204 1.6083375617695613e-06 / 1.8297985260415566e-08 / 5.676604686582581e-08 / 4.561722639281827e-07 / 2.7263615702723626e-06 / 6.194080837624687e-07 / 1.2533181199972694e-06 / 0.00011131713990719029 / 4.864543347378877e-07 0.009251 9 11 CAMKV_4 0.0000000014 5.551416714792332e-06 / 0.0008366625106022517 / 0.0005748885432290085 / 2.2091746366723067e-05 / 0.0012478612516330242 / 0.0013687527180138105 / 1.5647557069044988e-05 / 5.021668210368932e-05 4.61338946784834e-09 / 8.552882219336728e-06 / 1.2084936819520143e-05 / 7.064438585065973e-06 / 0.0003375551467252637 / 1.1640523808727713e-05 / 7.01115214482234e-05 / 4.699480658072907e-05 0.000515 8 12 TPMT_3 0.0000000000 7.28786952864283e-07 / 3.56646279188718e-05 / 9.6666658281473e-06 / 0.000778043526031782 / 0.0009044201128473978 / 0.0021692955083051683 / 0.0005370416183224255 / 9.028956735669806e-05 1.4274492942468779e-08 / 1.0767623030922322e-08 / 5.322824205944157e-10 / 6.914371271776401e-08 / 3.193252019194024e-06 / 3.3380153156051058e-06 / 1.3843642927526513e-06 / 1.514974348380039e-05 0.000566 8 13 WASF1_3 0.0000000001 3.6965068162525554e-06 / 0.0012954933098786366 / 1.5026939104998247e-05 / 6.092048706938309e-06 / 5.7827307263502816e-05 / 3.710694976569371e-08 / 2.4065055735879793e-06 / 0.0066209312465568835 1.8963621043904114e-06 / 1.942674022825637e-09 / 1.4008670359077526e-07 / 7.984757203592169e-07 / 1.807601980567127e-06 / 1.014708711120146e-06 / 9.411427127533182e-07 / 2.7376810453016147e-06 0.001 8 14 DDX25_4 0.0000000000 4.227069860488674e-06 / 1.1933180927019854e-06 / 1.275889510970952e-05 / 0.00014312717982028765 / 0.0001971578481272282 / 0.0007128346948758641 / 0.005660294390019774 / 0.002987411679461687 5.868503968366881e-07 / 1.6672256393335718e-07 / 7.607024358338446e-07 / 4.007532632723821e-06 / 5.422908721198046e-06 / 4.226087433911996e-06 / 1.9844578914555127e-05 / 1.348050130807739e-05 0.001215 8 15 ACVR2B_5 0.0000000000 0.00031701458152281776 / 4.014660005410256e-05 / 8.837943468799988e-05 / 1.2223170855538867e-05 / 0.00417544874823594 / 0.00027313653971257405 / 0.006738885955615125 / 0.00033890163674631904 4.22669945715201e-07 / 7.742783641708327e-10 / 2.0483971869730718e-07 / 1.239958147162055e-07 / 4.939171357902516e-05 / 4.120212263097594e-06 / 0.0006361321771264191 / 2.7380093694423655e-05 0.001498 8 16 TAP1_4 0.0000000000 1.049031460757783e-06 / 0.0003635757182364942 / 3.753398348762388e-07 / 0.00028733812150622895 / 0.0007167010349785833 / 2.307106816252697e-05 / 5.337901424957087e-05 / 0.020106125155811467 1.3332679478124245e-07 / 1.1868875335385447e-05 / 2.7070790605645726e-06 / 7.056569159589176e-06 / 0.0002157049138716117 / 4.445857267298034e-06 / 3.642358929245767e-05 / 2.406762142831913e-06 0.002694 8 17 SMPD1_1 0.0000009495 0.003065043011644369 / 0.0023157697041580965 / 0.0012909968347916095 / 0.0006256240573576323 / 0.007223252257555813 / 0.03771188975485943 / 0.0003890294490866307 / 0.00736333395639105 5.955099761237206e-13 / 3.051847715980306e-09 / 1.8525537737343062e-08 / 6.490954203776185e-06 / 9.743943487605562e-08 / 1.3599979831920288e-06 / 8.962608566425138e-06 / 5.6013193436695554e-06 0.007498 8 18 PEA15_5 0.0000000000 0.0002596888575908078 / 0.0013300138356594274 / 0.00524721075079139 / 0.006442952776112118 / 0.018912868681800837 / 0.01937026642721713 / 0.01438287077969559 / 0.0004932314709699339 4.44845454863038e-09 / 1.0130302320647733e-07 / 4.515074038541242e-07 / 2.962208123523371e-06 / 1.8659873824466947e-06 / 2.323546008318182e-06 / 2.7318856566845997e-06 / 1.1792288071015321e-05 0.008305 8 19 SLC25A43_1 0.0000001166 0.0012903447119515423 / 0.004158933151515996 / 0.008351774878422811 / 0.04843122350083363 / 2.540557327027098e-05 / 0.0003105144729205529 / 0.010869042090733612 / 0.02588573867516253 1.891414179412052e-09 / 2.1049137124860745e-07 / 5.230089820717235e-09 / 8.635969388699494e-07 / 5.5411681205887995e-08 / 7.317272575393834e-07 / 4.148735135683505e-07 / 3.228573281191034e-05 0.012415 8 20 MT2A_5 0.0000000000 0.00011447752236282417 / 0.0002544633476725284 / 0.00017859214428829218 / 0.0005165077368872941 / 0.00014503469256866046 / 0.000601999882354011 / 9.573116134444548e-05 1.584500848087154e-07 / 2.51478016245715e-07 / 8.54720361712193e-07 / 6.516915144267419e-06 / 5.171536692079251e-06 / 8.802100259189991e-06 / 1.6314636428146748e-06 0.000272 7 21 RUNX1_2 0.0000000000 0.0005559642828812122 / 0.0008971360026655244 / 0.0009701318251119559 / 1.7922091488637388e-05 / 0.00017935064903782676 / 0.0025863116474804755 / 0.0001657906685047857 1.9576595780585085e-10 / 2.1776070811919277e-07 / 7.527037299722958e-07 / 2.559009185958782e-07 / 2.2176040120466972e-05 / 2.5598942326458564e-06 / 8.17316116112682e-06 0.000768 7 22 LRRC8B_3 0.0000000000 9.4941920370122e-06 / 0.0015781807884715357 / 0.0002622885842506721 / 0.0011548969209222207 / 0.005697781111749079 / 7.700053244511214e-06 / 0.001483718198167863 4.296394955066174e-08 / 1.4324682153058617e-05 / 1.7104030080984345e-05 / 7.565682931060495e-07 / 1.624606018039645e-05 / 4.1115916939474605e-06 / 5.004433338367946e-06 0.001456 7 23 PSMB9_4 0.0000000000 1.1255116843939685e-06 / 7.444306538180959e-05 / 8.121302745530734e-05 / 0.006696643814464557 / 0.0001492527064854631 / 4.25829047419839e-06 / 0.003283436953926786 5.9405281136078796e-08 / 4.799096156918887e-07 / 6.170625684612102e-06 / 1.4805988081664244e-06 / 1.6676304471263215e-05 / 2.337476084860884e-05 / 2.138799423764577e-05 0.00147 7 24 RRAS_5 0.0000000000 8.182509603383713e-07 / 0.00021369162894747652 / 0.003190351183802246 / 0.00679937164887004 / 9.99040056201094e-06 / 0.002342765582078353 / 0.00018160002648956962 2.876707427462528e-08 / 6.680110293230449e-07 / 5.972855062819303e-07 / 2.8451937899285467e-05 / 7.687368595573398e-06 / 7.477786594755585e-07 / 1.3224569563917872e-06 0.00182 7 25 TMBIM1_5 0.0000000000 2.322967022611346e-06 / 4.188818420450373e-05 / 8.859519927799691e-07 / 6.20461992462773e-05 / 0.00026413620242118544 / 0.00014398625006041495 / 0.014948105524536974 9.353599152353929e-08 / 5.844591678215266e-07 / 1.5978510581326625e-07 / 9.291490547025219e-07 / 2.7475634725757366e-07 / 4.753956509088212e-05 / 9.311198865860414e-07 0.002209 7 26 KLHL23_3 0.0000000004 0.00012805365107500054 / 0.002519598458842781 / 0.0004515536091125032 / 0.00022680614492479574 / 0.009733620762754698 / 0.0042912100983332774 / 4.9219858574682586e-05 9.921726897145688e-09 / 8.717866079599918e-06 / 8.841783359385233e-07 / 1.1383657613478495e-06 / 0.0008824236923248849 / 3.398353518910182e-05 / 5.795994893765768e-07 0.002486 7 27 EWSR1_1 0.0000005663 2.098169823270148e-06 / 0.00920357999307954 / 1.7711409436331332e-05 / 0.0014863302195178008 / 0.0014863302195178008 / 0.005409509534570436 / 1.9786173221795818e-05 4.043867582082559e-07 / 8.844612889243844e-05 / 2.099411528051961e-06 / 6.37244282155154e-05 / 3.479676125457968e-06 / 4.563731385373264e-06 / 8.51275649150399e-06 0.002518 7 28 ZNF124_3 0.0000000174 0.01185115455025083 / 0.0028820143512348784 / 0.0006400036981941583 / 0.00022237327343913756 / 0.0017326407356747695 / 0.0002237032245520265 / 0.0002896824687842766 3.830190864530467e-08 / 0.0005023437846254026 / 1.4341269466072291e-05 / 1.9187040433353085e-05 / 3.0536343957588886e-05 / 0.00015912558081257976 / 0.00030057122653906633 0.002549 7 29 CAPG_2 0.0000000000 0.00016360654996415964 / 0.003107700700013517 / 0.004526868535758527 / 0.003825441026009639 / 0.00040288084200566923 / 3.2262553686676067e-08 / 0.006275421665752097 1.6061695068770962e-09 / 6.708972026453563e-07 / 6.9252484921311626e-06 / 8.27034474165013e-06 / 9.342485200961395e-05 / 8.711780875641735e-07 / 5.302432363858073e-06 0.002615 7 30 TGOLN2_2 0.0000000030 0.0002870649623628604 / 0.005727463389908907 / 1.203780953398585e-06 / 0.00027661203249205183 / 0.0005689555709178733 / 0.0006501827815986053 / 0.014330254737635668 3.619262458649237e-11 / 4.769486326622182e-08 / 1.6622051928852046e-08 / 3.6038229751219804e-07 / 4.940074588134348e-05 / 1.8592574634706461e-06 / 7.392344957282081e-05 0.00312 7 31 RBFOX1_1 0.0000008465 0.0006456808009902826 / 0.0009805618383529596 / 0.0005802206884848052 / 0.0007177403550416762 / 0.00731321321837694 / 0.0011231690936696782 / 0.010617152378270862 2.2848739279053027e-11 / 3.403410943591806e-08 / 5.3253671669888775e-06 / 5.391441835390658e-06 / 9.82032865139159e-07 / 4.249582206860703e-06 / 4.042294162166094e-06 0.00314 7 32 RANBP2_2 0.0000000020 0.0032005645957622507 / 1.1292974727160135e-05 / 0.004582586266801288 / 0.005968942599275744 / 0.0007669246686613953 / 0.0003836018962680972 / 0.01256992621275457 1.0278781040318966e-06 / 3.2181914215686755e-07 / 9.03950843772086e-07 / 2.2352937628807305e-06 / 1.2237851910310582e-05 / 2.3260388622347645e-06 / 3.157729990156927e-05 0.003926 7 33 CCT2_1 0.0000000610 0.00037839447623271325 / 0.00042879723237597764 / 0.001443320215490813 / 0.00028286232014178015 / 0.008201744521300066 / 0.002944369153927747 / 0.01649068093735444 1.2749486030115433e-08 / 1.1225851282580173e-07 / 6.873884305086476e-09 / 2.2752402825301866e-07 / 1.0015662188091184e-06 / 3.453963505596524e-06 / 5.058184693460015e-06 0.00431 7 34 CEP95_2 0.0000000004 0.0007190070321581675 / 0.0002545171218429651 / 0.0035966015072663835 / 0.0025521170193974763 / 0.0003107381669592285 / 0.027502917617089746 / 0.0012110736028058307 1.3949676285490207e-07 / 2.1170919481613956e-08 / 2.8596627227079915e-05 / 9.032373803983716e-08 / 4.00753265620622e-06 / 6.457362557632581e-06 / 4.791358118111102e-07 0.005164 7 35 GINM1_3 0.0000000000 2.8556636750809756e-05 / 0.00012092027077076626 / 0.004350456289105647 / 0.0028744599511057625 / 0.009781859661254071 / 0.012315629622740824 / 0.014183888091677869 3.741940140138828e-09 / 6.30551384179601e-07 / 5.723523849148954e-07 / 4.137409181237638e-07 / 4.058957920972812e-06 / 1.324094056480911e-05 / 5.334206696833551e-06 0.006237 7 36 POLG2_2 0.0000000067 0.0002576770516093337 / 0.0016833422652258513 / 0.01537032415812942 / 0.0199546774517756 / 0.011879693396648705 / 0.013778504455704959 / 0.0006073423559504219 8.002612553216828e-12 / 2.5154718511604325e-07 / 5.542657615241579e-07 / 6.569612124521097e-06 / 5.133965042123324e-06 / 4.188709032414043e-08 / 6.35362381394998e-07 0.009076 7 37 RAN_2 0.0000000007 8.10356681117687e-05 / 0.0015745833133913741 / 0.0003323999875867436 / 0.014323464285551478 / 0.003484183595989438 / 0.0003293358901815535 / 0.045671136243731716 4.467053904818645e-09 / 8.90912425766829e-06 / 2.7276695958874614e-07 / 1.6612137127547922e-06 / 4.295327136339735e-06 / 0.00010945540484186873 / 0.0007487722885105004 0.009399 7 38 MTF2_2 0.0000000001 0.00024102538797346086 / 0.001539940029122352 / 0.005818462625160796 / 0.04331587497952318 / 0.003473006180561586 / 0.013123198329328149 / 0.0011086944827796786 5.524058788809012e-07 / 2.255174371885246e-07 / 1.0230509628865922e-08 / 1.5272339234163363e-06 / 4.502242650312079e-06 / 1.4470801258175914e-06 / 4.0947329724111495e-06 0.009803 7 39 CMPK1_1 0.0000099465 0.01615823448153983 / 0.03373282648472924 / 0.016556829420777325 / 0.01344459083967992 / 0.0011586570434241133 / 0.007942503974326632 / 0.006386843886902124 2.364261967442666e-08 / 5.989349364171967e-07 / 1.051890467879646e-07 / 2.8069595654757565e-06 / 2.675202019953556e-06 / 4.952772665629785e-06 / 8.5101324606656e-06 0.013626 7 40 MDN1_1 0.0000149331 0.027136920905959004 / 0.015382714940475899 / 0.0002021790532799894 / 0.025082579510674555 / 0.002667939855033078 / 0.01903033340546255 / 0.023433853775319136 3.1384912120068307e-10 / 9.325247533918398e-06 / 6.936897377329882e-07 / 2.353698101267621e-06 / 1.4783005405825795e-05 / 1.3845703258818903e-06 / 3.794277797288223e-07 0.016134 7 41 INPP1_2 0.0000000458 0.00012405403034171616 / 1.718785742696879e-05 / 6.396622257100077e-06 / 6.925570695765487e-06 / 3.9200560425745034e-05 / 1.2385564215356241e-06 5.3962567655992866e-05 / 8.480907105422951e-07 / 2.8149687924382837e-07 / 6.886821060328188e-06 / 4.946024817438151e-06 / 2.5531357893982e-06 3.25E-05 6 42 TOMM20_5 0.0000000000 9.847481167714172e-07 / 5.461787394016582e-07 / 2.630785074908594e-05 / 6.807575706103957e-07 / 6.31788143549132e-07 / 0.0002787072964560934 1.828485836400758e-09 / 8.488593461887543e-08 / 4.561158256034957e-06 / 1.357508261446604e-07 / 2.9348649605847958e-06 / 1.3733983916997187e-05 5.13E-05 6 43 S100A6_3 0.0000000000 3.987563090636182e-09 / 6.751332523310354e-08 / 5.131148780828573e-06 / 5.346137072472972e-07 / 0.0008192357956865613 / 1.657842655825674e-06 1.8859563430955987e-09 / 1.5597048970633669e-07 / 6.731790637644895e-07 / 3.923562825747655e-06 / 7.57844698984901e-05 / 1.7516083103081196e-06 0.000138 6 44 ZNF74_5 0.0000000000 7.220170669604226e-07 / 0.000560135938998767 / 3.1675474781598684e-05 / 0.0005276313183088553 / 2.1660265856759415e-06 / 0.00015601716830048032 1.4629848729112387e-07 / 1.1761012404538385e-06 / 4.011024961679582e-05 / 2.0573826720469716e-06 / 2.0056325015251253e-05 / 3.125081554604303e-05 0.000213 6 45 ZNF195_3 0.0000000000 4.2041150573934295e-05 / 4.5529669866602804e-05 / 0.0007203033990971563 / 0.00014468246920967197 / 0.00031951653993607604 / 8.595632585615447e-05 6.719675625838534e-09 / 3.8056480729458196e-09 / 7.723330075061024e-07 / 3.1795531703660226e-06 / 4.735362185795e-06 / 1.0975067398076295e-06 0.000226 6 46 DNMT3A_2 0.0000000000 6.115665040218944e-06 / 3.206324028832219e-05 / 8.429951747175733e-05 / 0.00019962122279230926 / 5.615553156462022e-07 / 0.0021806139002983004 1.511429559536217e-08 / 3.3834848660671585e-06 / 1.0925063596049997e-07 / 6.95434985454603e-08 / 4.9915249752075324e-06 / 2.7418564056278035e-05 0.000417 6 47 PXDC1_3 0.0000000000 0.00018564783748412937 / 0.0006324544157642112 / 0.0008799932868837088 / 0.0012100854406902743 / 2.4460595957570077e-05 / 9.238919654315156e-05 1.629093796438785e-09 / 2.354828010860969e-08 / 1.1437120990282457e-06 / 2.506826726053496e-07 / 1.4404482300034928e-05 / 1.341496646230468e-07 0.000504 6 48 HOXD8_1 0.0000011390 1.384655004104117e-06 / 2.098169823270148e-06 / 0.00013057839781136293 / 0.0006273187563236247 / 0.002391299161389133 / 0.00012418009082273935 4.462177612672371e-06 / 3.7108705034506107e-07 / 2.588422064155111e-06 / 4.951039991487746e-05 / 1.3325001401014987e-05 / 0.00014465241485038646 0.000546 6 49 CREB3_5 0.0000000000 0.00011974638832910611 / 2.8492275991361182e-06 / 0.0002672299360603039 / 0.0015619495448511997 / 0.0006694225755824582 / 0.0007820104355851261 3.367539235619778e-08 / 2.960146168251713e-09 / 3.5507108068252503e-07 / 1.15634806074712e-07 / 9.547786692388759e-08 / 9.283068268133278e-07 0.000567 6 50 HDAC2_5 0.0000000000 0.0024571245521046946 / 0.00027132067925628834 / 9.682089638458799e-05 / 0.0005745209404259057 / 0.0011143521019561335 / 8.813885171995659e-06 5.2270805905618696e-06 / 5.052158985938859e-07 / 2.8819687490380823e-06 / 2.0125230234433194e-05 / 2.0453412309359413e-06 / 2.7524824404052385e-05 0.000754 6 51 TIMP1_5 0.0000000010 0.0007131856153707479 / 0.004395200198238863 / 0.0007246067046570448 / 0.0004898581392129352 / 0.0005314272666539294 / 0.0011397228331407 5.172684196778569e-07 / 2.311501161730639e-05 / 3.21307883800088e-06 / 6.009010264662183e-07 / 8.327439275864646e-05 / 1.1941646912994778e-05 0.001332 6 52 COQ10B_2 0.0000000036 0.00028381156148520563 / 0.0011945192630844516 / 9.355412559125023e-05 / 0.00011447010352733596 / 0.004266156536665072 / 0.006336011637689165 9.039504276825803e-09 / 6.006195461219958e-11 / 1.974259905174528e-07 / 1.2053082748861081e-06 / 5.363487408950924e-07 / 6.630188454539638e-06 0.002048 6 53 REEP5_3 0.0000000001 0.0002604645915174344 / 1.6662214108439007e-05 / 0.0014440576489070092 / 0.007046402501490371 / 0.0001422863963685906 / 0.003637547802268041 1.5498910474749387e-08 / 1.5248778277061658e-07 / 4.842659456067433e-07 / 1.1491084964019146e-05 / 9.94537200846768e-06 / 1.9463332862931604e-06 0.002091 6 54 FAM111A_5 0.0000000000 4.4898969618553406e-05 / 2.4668455632971913e-06 / 0.008396935784803085 / 2.1285938805234283e-05 / 0.00017201334171284462 / 0.00396513630435739 2.8379627983912504e-07 / 5.011442931035688e-06 / 2.7338260851547263e-06 / 8.36960570585275e-07 / 0.0001410578503689771 / 0.00014811827476060585 0.0021 6 55 XPO5_2 0.0000000001 0.0001209623595819047 / 0.000188340547489593 / 0.0018652619870494437 / 0.00021645065939681314 / 0.003380556290063177 / 0.008610130886641778 3.868080212014016e-11 / 9.213293248318617e-08 / 1.7999848646465621e-06 / 2.4843669693960186e-06 / 4.8157427373392145e-06 / 1.6123249086459064e-06 0.002397 6 56 MICALL2_2 0.0000000015 0.0033273695719493366 / 0.0003451393798156882 / 2.1541055929197527e-08 / 1.9308695609987287e-05 / 0.00038134035343875063 / 0.012364148039779468 7.498455684868167e-10 / 1.4582924103607157e-08 / 1.3913032862815633e-07 / 5.643046267928915e-06 / 9.075353821264667e-07 / 6.490175971759533e-07 0.00274 6 57 ITGA3_1 0.0000000030 0.005770181686062503 / 1.2412020538304333e-05 / 0.0014786332863597391 / 0.0025299472548494955 / 0.006820424547488444 / 0.0005531418384342248 5.922775528802422e-07 / 4.6735775256735116e-07 / 1.1163600156129396e-05 / 1.4439518922300546e-05 / 2.1428615198188343e-05 / 0.0004769133582838131 0.002861 6 58 MATR3_5 0.0000000205 0.011926215274063212 / 0.0009331303043566046 / 0.0010276150171031416 / 0.00182336903581431 / 0.0003580914875982602 / 0.0015078412320002777 4.924418504897322e-07 / 1.370559303361593e-06 / 1.6001662179812555e-07 / 1.1659751397403969e-06 / 3.3107751763197302e-06 / 0.00023808544096258719 0.002929 6 59 SAT1_1 0.0000002126 0.00037839447623271325 / 0.00010681753824403367 / 0.001443320215490813 / 0.00028286232014178015 / 0.00042879723237597764 / 0.01649068093735444 2.471908559304084e-08 / 1.0167276826134301e-07 / 4.27349479221232e-08 / 1.9148903772583427e-06 / 5.811635331171456e-06 / 2.062293334552713e-06 0.003188 6 60 TMED9_2 0.0000000049 0.004580742781866771 / 0.00013157696997892983 / 0.004688381529867688 / 0.009588847065017484 / 0.002359920632447335 / 2.045294378465323e-05 2.311738097680596e-07 / 3.385203606751943e-07 / 1.428134704742174e-06 / 2.2508154783841546e-06 / 8.005735739477652e-07 / 5.167281077719583e-06 0.003562 6 61 KIF26A_2 0.0000000001 1.5469524150486244e-06 / 8.296463018176517e-06 / 0.006895380226562706 / 0.012900561921483814 / 0.0032271260560706324 / 0.00021924462904813837 1.5344327905473364e-07 / 2.061988698426251e-05 / 8.65696212540371e-05 / 0.00020969562979674127 / 2.9068598486233544e-05 / 7.962530247357052e-05 0.003875 6 62 C19orf66_2 0.0000000010 0.00034498616340953534 / 0.011682032301995177 / 0.00022585824160449916 / 0.0007089738037200934 / 0.002717071783164195 / 0.0083826665816656 1.6212467312990448e-07 / 8.055304607431e-07 / 2.1285718913705297e-05 / 6.7336653328809105e-06 / 9.184791210195023e-06 / 5.963654428661317e-05 0.00401 6 63 GTF3C2_2 0.0000000532 1.1143488565728274e-05 / 6.351892014238265e-06 / 0.00014033845457246834 / 0.0056660681635887335 / 0.018064176445119352 / 0.001679572583230773 5.3778331923390924e-09 / 3.451157087485289e-08 / 1.036058010685455e-05 / 6.86847495002417e-07 / 2.1756858153773495e-05 / 1.4832082275306326e-07 0.004261 6 64 ADAM9_5 0.0000000000 9.192181643816992e-05 / 0.01456393928510654 / 0.0024406101382475976 / 0.0003651548756090639 / 0.002859171921278692 / 0.005910547863522942 1.2444797620355103e-06 / 0.0006441060918252728 / 6.0935458892623245e-06 / 2.470519395812343e-05 / 6.138314516641965e-06 / 0.00047208959650121314 0.004372 6 65 KDM1A_3 0.0000000105 0.00020172074167490282 / 6.059446073630997e-06 / 3.4966947244211546e-05 / 0.00035787841907612255 / 8.084536486163457e-05 / 0.030001525763098943 1.9191726349291212e-07 / 1.1031846529359998e-09 / 1.1293378746596968e-07 / 3.850331218970383e-06 / 3.0967264542843456e-07 / 4.878540657681566e-06 0.005114 6 66 SRSF1_1 0.0000149516 0.003065043011644369 / 0.00022847309395920425 / 0.007223252257555813 / 0.002399019537670231 / 0.0023157697041580965 / 0.016498427519842422 1.756253200088118e-08 / 1.4552116534728694e-07 / 1.9822115797618054e-07 / 0.00022932374573720484 / 8.206690733883024e-07 / 2.2543227834379112e-07 0.005288 6 67 WHAMM_1 0.0000006802 0.00173044075017522 / 3.679473658399758e-05 / 0.007154235078360664 / 0.0005658979552839525 / 0.022166841169996183 / 0.0008973831238703076 1.819882893948959e-08 / 7.796445160214981e-06 / 4.241150850168489e-05 / 2.1522400443486433e-05 / 1.3244633411180583e-06 / 3.4248686087626584e-06 0.005425 6 68 LEPRE1_4 0.0000000000 0.0009439710790866046 / 0.0005817669851518343 / 0.001866551132439743 / 0.0064518824694126935 / 0.024010305513094434 / 0.0005799813920946167 5.057896230784973e-09 / 1.2435409883337575e-09 / 4.849591006599988e-07 / 2.513207633152382e-07 / 7.926212421845088e-06 / 9.994009471711418e-06 0.005739 6 69 TRMT61B_1 0.0000029142 0.00019565429421873628 / 9.250262180987785e-07 / 6.358888418896258e-05 / 0.007843131253822322 / 0.026473307528210963 / 0.0005756579425604447 1.5078060373014486e-07 / 2.934542273575563e-07 / 1.2562708953802216e-08 / 5.523864073902343e-05 / 2.1559815321332083e-05 / 3.99120679034904e-07 0.005859 6 70 KANK1_1 0.0000005033 0.00029139375190295606 / 0.009220967328515883 / 0.008770410107355643 / 0.014437131210731376 / 0.002271551295087959 / 0.004557941079021841 5.395125257906878e-09 / 1.5463446946793206e-07 / 9.30211963759247e-07 / 1.5254780926528496e-05 / 2.370997764208311e-05 / 3.6188491330904777e-06 0.006592 6 71 FAM126A_1 0.0000010549 8.712601577854501e-09 / 4.778480179883678e-05 / 0.029987683740818265 / 0.0006110060061203364 / 0.0014562282237067896 / 0.010748894710017389 5.924782315476787e-13 / 7.1855057793508855e-09 / 5.8414503343797016e-08 / 3.0767728402054146e-07 / 3.866278498641532e-05 / 6.044718602493066e-06 0.007142 6 72 CASKIN1_1 0.0000009531 0.0004052971561229435 / 0.004531342266561176 / 0.0026490796375761676 / 0.0030838618137353662 / 0.0016555906467057811 / 0.03955358967054088 6.0724511656641e-08 / 2.4239072038012358e-06 / 2.9932584561794108e-06 / 2.381049500017635e-07 / 3.5273148222341567e-07 / 8.97249895656115e-07 0.008646 6 73 PHIP_3 0.0000000007 0.00021593310745224813 / 0.001021373946566871 / 0.000875589310570064 / 0.03219163721249994 / 0.018101605571703944 / 0.0018008865475031112 7.804787711336222e-10 / 7.962047079615459e-07 / 1.3767715926221406e-06 / 9.21068648623731e-07 / 2.0427438064371946e-06 / 2.061133383896347e-06 0.009035 6 74 ISL1_1 0.0000011109 0.00029139375190295606 / 0.004557941079021841 / 7.763485144629643e-05 / 0.03147989324458417 / 0.009220967328515883 / 0.014437131210731376 1.0776705684350702e-07 / 9.139106854866213e-08 / 1.5262551782073314e-06 / 7.17589463363722e-05 / 1.6643398808959587e-05 / 2.7254012211130744e-05 0.010011 6 75 FAM114A1_1 0.0000011740 0.008158453075892491 / 0.00706078944078839 / 6.392429369799613e-05 / 0.047093499348454915 / 0.0011036487237694873 / 0.0012146763275784356 3.9222069331739446e-09 / 1.0484859600093688e-07 / 1.1328590320930398e-08 / 1.4044847451826967e-07 / 1.6732185403869882e-06 / 2.0603621902808526e-07 0.010782 6 76 BHLHE40_5 0.0000000001 0.0007215354754391255 / 0.0003445000837785309 / 1.9977845432945953e-05 / 0.04162183582083479 / 0.0018003544554504962 / 0.022135056393026143 1.9299792697031883e-08 / 5.991364646156074e-06 / 6.2842442407564126e-06 / 7.23523138723521e-05 / 4.37410397098931e-05 / 8.612084128833267e-05 0.011107 6 77 RNH1_2 0.0000001050 0.000506059688566897 / 0.005186853257558283 / 0.012649170673498711 / 0.001227543851685287 / 0.02830343719752466 / 0.04658173961213423 1.9114165577673726e-07 / 1.1785627242528596e-05 / 1.1961430183679334e-05 / 5.5941363386033185e-06 / 0.0003160168984552755 / 6.436245153753663e-06 0.015742 6 78 SLC35F5_2 0.0000000018 0.0004361351075887015 / 0.022927539814265496 / 0.04092933544326924 / 0.006547044668673556 / 0.028271710657491178 / 0.00020952110146219778 4.764738756551879e-09 / 4.080828723669075e-06 / 3.470949128294469e-05 / 1.4915989057385644e-06 / 3.6434591065850956e-07 / 5.290028218404434e-06 0.016554 6 79 TRAP1_1 0.0000001560 0.0020456136275657888 / 0.002859168680149655 / 0.005851685675009941 / 0.01576374271095223 / 0.026715472976530045 / 0.04871212229027521 3.490113886399775e-11 / 1.4427864532484367e-07 / 6.218256736106799e-06 / 8.405023850544253e-07 / 1.4752725092614505e-05 / 0.000126359581600695 0.016991 6 80 SLC10A3_1 0.0000020963 0.011413935706631708 / 0.017443397981769932 / 0.014660785392642973 / 0.017145541610166553 / 0.03683753470884825 / 0.010610163045225487 5.700211166503259e-07 / 1.392805628701067e-07 / 3.319072411206087e-06 / 4.021260874574252e-06 / 1.6786320992493728e-06 / 6.426344116619477e-06 0.018019 6 81 IL10RB_1 0.0000014439 0.0018473350729729212 / 0.025082579510674555 / 0.015382714940475899 / 0.01903033340546255 / 0.042397669225769964 / 0.010590633670572098 6.305508475517821e-07 / 2.1289852323575975e-06 / 1.3929853301059418e-05 / 5.9674182467591734e-05 / 0.0005196865649666491 / 8.689281900910874e-05 0.019055 6 82 CCDC138_3 0.0000000000 2.8507575756692187e-05 / 8.39983457440053e-08 / 5.171191093952371e-06 / 0.00013241015291548088 / 0.00013231289428074683 3.594844984072266e-08 / 4.1699450769671714e-10 / 1.7829184957785041e-06 / 1.6716512185751531e-07 / 6.673606916636778e-06 5.97E-05 5 83 LDLRAP1_1 0.0000008179 0.00011095297992729127 / 5.264359468000088e-05 / 0.0011242387519002353 / 4.668223816223458e-05 / 1.2920956774321015e-06 7.024419920758419e-08 / 3.7947570137300835e-07 / 1.3563326532912054e-07 / 8.17408329321785e-05 / 8.828337775002166e-05 0.000267 5 84 SH3BGRL3_3 0.0000000001 4.2473135511991315e-05 / 0.00018110968427817472 / 2.3012675922598175e-05 / 0.0012229341595829208 / 7.876891018158643e-05 6.991877310539878e-06 / 9.480200177754412e-06 / 0.00015579668074547338 / 1.8811555342370173e-05 / 6.910060016993254e-06 0.00031 5 85 RARRES3_3 0.0000000000 5.445858436353469e-05 / 0.0009962374983153238 / 0.00039011483425120365 / 0.00012136000976514409 / 3.791878524439541e-05 1.56194833594799e-09 / 1.296245999203945e-06 / 1.1756173797034747e-06 / 1.527843952821709e-05 / 5.848148683004699e-07 0.00032 5 86 ANXA4_4 0.0000000000 1.363288691355937e-06 / 1.5143046244596162e-05 / 5.189840282140393e-05 / 5.782599824929034e-05 / 0.001524236220832947 1.0031685363992852e-08 / 6.841456697948725e-09 / 1.9180526546377784e-06 / 8.794172382219916e-06 / 2.953468988272718e-06 0.00033 5 87 LYST_1 0.0000027714 0.0014431024451110606 / 5.264359468000088e-05 / 0.00011095297992729127 / 0.00020173841888508878 / 6.995348463708383e-05 1.1240472731245707e-08 / 2.350080008352624e-06 / 1.1075551169706485e-06 / 1.7042664405713885e-06 / 4.2116046384684526e-05 0.000376 5 88 MR1_4 0.0000000000 7.715095979792449e-07 / 0.001693666645875025 / 6.395023692800854e-05 / 0.00031256159798863684 / 3.9188876899229826e-06 1.1557582761220409e-08 / 5.677180579700876e-06 / 2.8754646285556484e-06 / 5.64979021764616e-07 / 1.8797358227572578e-05 0.000415 5 89 SELRC1_1 0.0000005524 0.00037839447623271325 / 0.00042879723237597764 / 0.001443320215490813 / 0.0004410378323337517 / 0.00010681753824403367 1.2864802377615588e-11 / 2.1196501777135548e-08 / 1.3367474421932726e-09 / 7.5658631683473564e-06 / 5.602327158926525e-08 0.00056 5 90 LDHB_5 0.0000000000 2.9413591946334052e-06 / 0.00018071660821354673 / 1.726070100137361e-05 / 0.0006331647449173639 / 0.0029940534519961185 2.3674403554451728e-09 / 1.5213269839159292e-06 / 4.075392395353731e-07 / 1.8533263086532664e-06 / 6.582873587671421e-05 0.000766 5 91 GBE1_2 0.0000000003 0.0033273695719493366 / 2.1541055929197527e-08 / 1.9308695609987287e-05 / 0.0003451393798156882 / 0.00038134035343875063 5.906459505383357e-08 / 2.4094693488118412e-09 / 1.0620489017054289e-07 / 6.750639833651121e-07 / 1.8752484455808676e-05 0.000815 5 92 PTRF_2 0.0000000003 0.0033273695719493366 / 2.1541055929197527e-08 / 0.0003451393798156882 / 1.9308695609987287e-05 / 0.00038134035343875063 4.017261878814523e-08 / 7.146428295045248e-09 / 6.101976957550238e-07 / 2.1688184575439267e-06 / 6.686443921029525e-06 0.000815 5 93 SQSTM1_3 0.0000000000 3.9761649107081705e-05 / 0.0016006026930324019 / 0.0008611052684263142 / 0.0012009850065108874 / 0.0006237640708459632 4.01947151989452e-07 / 1.339226375307952e-06 / 1.754090841474079e-06 / 7.055430531026282e-07 / 2.6767693410519625e-06 0.000865 5 94 PA2G4_1 0.0000000017 0.001443320215490813 / 0.00037839447623271325 / 0.00042879723237597764 / 0.003993715376548959 / 0.00028286232014178015 3.045245115555592e-10 / 1.8399976601880802e-08 / 5.830030485334704e-07 / 9.508100999171547e-06 / 1.13769352855429e-05 0.001305 5 95 GBP3_2 0.0000000003 0.0005839379621670203 / 1.3428726435262393e-05 / 0.005991852836482861 / 0.0001081781120537704 / 2.8744610334651343e-06 4.819954330621288e-08 / 6.412523041836917e-07 / 2.8569657952677404e-06 / 2.0985004888144685e-05 / 2.3525509311119436e-06 0.00134 5 96 CHD7_2 0.0000000001 0.0018350968591216627 / 7.477363698097769e-05 / 0.00015975427450238799 / 0.00391277170211791 / 0.0008685464813169234 1.0531573829941702e-07 / 7.878415280920932e-08 / 1.1141611641319887e-07 / 5.1757956178869716e-06 / 8.934190321293886e-06 0.00137 5 97 ELF4_4 0.0000000000 1.5042859087051511e-05 / 0.0015054443180049152 / 0.0035324162802343384 / 0.0015681053781698034 / 0.00044306616234558656 1.0129117193066866e-07 / 3.803422404924242e-08 / 3.196969576173562e-05 / 2.0994506448972058e-06 / 8.674339153748824e-06 0.001413 5 98 HEXB_2 0.0000000027 0.0001364689621921479 / 0.0017139782149577006 / 0.00042251637580553855 / 0.004506824346577342 / 0.0011693468213267385 5.600402893224147e-07 / 1.7114753018966675e-06 / 7.859127616630422e-06 / 2.136847848300081e-06 / 1.057919545610576e-06 0.00159 5 99 TGOLN2_3 0.0000000000 0.002887936541355392 / 0.0012489133459296009 / 3.971802768150102e-09 / 5.351370414635355e-06 / 0.004542992850202789 1.5278667902264538e-08 / 6.147579495364705e-07 / 2.55317658003628e-07 / 9.866879372887889e-08 / 6.124699763744859e-06 0.001737 5 100 CBR3_5 0.0000000000 1.7429615872247697e-06 / 2.1772701241259695e-05 / 4.265116466854638e-05 / 0.0006691661140725223 / 0.009174735989250154 1.7321244665799745e-08 / 1.9865066542844766e-06 / 6.139861852092745e-07 / 3.5205839483278234e-06 / 4.046680434424515e-05 0.001982 5 101 C14orf93_1 0.0000000417 0.005409509534570436 / 0.0014863302195178008 / 0.002391299161389133 / 0.0006273187563236247 / 1.384655004104117e-06 7.500915749450172e-10 / 3.167346841801568e-06 / 6.173059623938025e-07 / 7.496583765477882e-06 / 2.018269137344719e-06 0.001983 5 102 ACVR1B_5 0.0000000000 0.0011897273750790794 / 4.043863569216427e-06 / 0.003135726107000613 / 1.2302005748125012e-06 / 0.005979891210353361 8.795727468366677e-07 / 1.740359378085258e-08 / 3.922859794878605e-06 / 5.715287595383605e-07 / 3.0426357547305182e-05 0.002062 5 103 WNK2_1 0.0000008965 0.004531342266561176 / 0.0004052971561229435 / 0.0026490796375761676 / 0.0016555906467057811 / 0.0030838618137353662 5.735186182795572e-07 / 4.097215580173646e-09 / 2.1966688549867895e-05 / 7.38514634627583e-06 / 9.495710202696889e-06 0.002465 5 104 GBE1_5 0.0000000000 3.826852437313171e-06 / 0.0010708658291423757 / 0.00019953068534511048 / 0.009169711616283972 / 0.0026316110463780696 9.044891469948086e-09 / 3.7048735780400227e-07 / 2.359441941877069e-06 / 1.5764817932193767e-05 / 2.274686348690355e-05 0.002615 5 105 RAB27A_2 0.0000000000 7.635253341668868e-05 / 0.005021656852415849 / 3.5215907075366917e-06 / 0.00034267788827357215 / 0.007895113233237851 1.914896020510999e-07 / 9.517291296985127e-08 / 7.969576900636687e-08 / 5.846288233066031e-08 / 4.5361993939378207e-07 0.002668 5 106 FAP_3 0.0000000006 0.0019684942173753836 / 0.0009928703588443979 / 0.0005051149609558843 / 0.00011232928113623314 / 0.012918030852908461 1.2766883170125572e-07 / 2.4021041707717316e-06 / 1.0836840144491595e-06 / 8.446479999419288e-06 / 3.6833375749558764e-06 0.003299 5 107 THBS1_1 0.0000000712 0.0019027179320774803 / 0.004613449756294485 / 0.0003168019030192227 / 0.0012733956455115425 / 0.010654255097368902 2.1096989696063183e-09 / 2.8418823932552776e-08 / 2.9577603926263325e-08 / 1.6345742810026593e-05 / 7.1941049967859985e-06 0.003752 5 108 RNF44_2 0.0000000001 0.0007973635551597535 / 7.563774009011881e-05 / 0.01008336409450162 / 0.004045539400699223 / 0.004865413756574913 5.271414210724663e-11 / 3.736942531550046e-07 / 2.3747819656119838e-08 / 1.893540361128054e-06 / 1.2212684566221971e-06 0.003973 5 109 C2orf44_4 0.0000000014 1.0808929306666273e-05 / 0.008934208121620274 / 0.00010039306136116464 / 0.009784265308543377 / 0.0024009587334497774 1.2187744602716387e-10 / 1.9588399373708684e-06 / 4.6145010226590306e-07 / 3.855402108931244e-05 / 2.3663313142656787e-05 0.004246 5 110 ZSCAN2_1 0.0000003244 0.005494404451518434 / 0.002117501407135496 / 0.015063580358728427 / 0.00406276527468287 / 0.00029389877591584477 4.440150276665828e-06 / 1.6041254678652375e-05 / 6.101223267687242e-06 / 1.4917171986665666e-06 / 1.8918665259353665e-05 0.005406 5 111 PSMB8_3 0.0000000001 1.1139371348435439e-05 / 0.000295206951604009 / 0.0011420234721703612 / 0.004002189263586216 / 0.022007285373854 3.18097586113718e-08 / 8.739864511743991e-07 / 1.4187996767508308e-05 / 1.4206186275488269e-05 / 2.1536287095072426e-06 0.005492 5 112 CTGF_2 0.0000000009 0.00015265799477510392 / 0.004284835035004821 / 0.005655033062620194 / 0.017812704981803436 / 0.00018190158542752172 5.263266054115357e-07 / 4.3695038068811766e-08 / 3.7740283990797325e-06 / 7.135038004681359e-07 / 2.643168822853883e-05 0.005617 5 113 DAP_1 0.0000000596 0.008158453075892491 / 6.392429369799613e-05 / 0.01165101001080378 / 0.00706078944078839 / 0.0012146763275784356 1.4736850125189888e-07 / 3.908902039015359e-08 / 1.7628401584823726e-07 / 1.5347002454072624e-05 / 1.7507947709175734e-05 0.00563 5 114 PHOX2A_1 0.0000003175 0.008158453075892491 / 6.392429369799613e-05 / 0.00706078944078839 / 0.01165101001080378 / 0.0012146763275784356 5.8181933193632506e-08 / 1.1078332486685944e-07 / 1.2847626080278513e-05 / 1.9169572452878826e-06 / 1.3210118079992226e-05 0.00563 5 115 MVP_2 0.0000000015 0.0003074328712443293 / 0.029215443986862575 / 9.407443780393908e-05 / 0.0007597570913260385 / 4.843098209783887e-05 4.002114425736759e-08 / 1.6803136761019638e-06 / 3.376253203984945e-08 / 1.008528085216226e-05 / 4.819827094154422e-06 0.006085 5 116 CCNJ_2 0.0000000010 0.005156889617706872 / 0.0037116981070019926 / 0.018339330602739977 / 0.0005410238034488199 / 0.0029241900112892644 1.3384145050432693e-05 / 1.2259034650488922e-06 / 2.418247349561274e-06 / 5.022621230368505e-05 / 3.457954174876677e-05 0.006135 5 117 MAP4_5 0.0000000001 0.0005031786684884779 / 0.010922608465190551 / 0.018146216162979706 / 0.0003254856473440077 / 0.001272088116869848 2.587716794178391e-07 / 3.798173592497599e-08 / 2.5392647842825153e-06 / 4.942693897536645e-07 / 9.527740137246758e-08 0.006234 5 118 ATP5B_2 0.0000000014 1.0473941865935008e-05 / 0.00047787043862318663 / 0.02960215538361295 / 0.001031466405675943 / 0.00013666281877242411 7.117260294468996e-09 / 6.152782689367921e-07 / 1.526236991383182e-05 / 1.8976244710357432e-05 / 2.5507040748716144e-06 0.006252 5 119 TRAM2_3 0.0000000000 7.050716055970537e-06 / 0.0001057656674813077 / 0.0025449721290128477 / 6.997404830789269e-07 / 0.03280415443708167 5.729353647005044e-08 / 1.910962326072629e-07 / 8.344215866087099e-06 / 4.014110177183549e-06 / 1.7722857190857362e-05 0.007093 5 120 CCDC107_5 0.0000000004 7.799742935751802e-05 / 0.023152072094571645 / 0.014505125297696268 / 0.00010031692846422633 / 0.00039456234783499816 2.5979973718838742e-08 / 5.275125038891406e-07 / 1.2574262998000307e-06 / 4.826438486358518e-06 / 3.332582738649872e-06 0.007646 5 121 SMARCAD1_5 0.0000000000 6.51572554597248e-05 / 1.121807735413933e-05 / 0.0009794106383235514 / 0.028651749233987035 / 0.016373864330489554 4.951274541156556e-07 / 4.932698411729371e-06 / 3.7416170837321407e-06 / 2.232387301624823e-06 / 6.909674555415473e-07 0.009216 5 122 HRH1_1 0.0000009062 0.007112363650923645 / 0.007730255820425719 / 0.02421022399736038 / 0.001383098528892269 / 0.006385380233425884 8.024725118266073e-09 / 1.3814036761412276e-07 / 2.07690167148044e-06 / 1.4044796518330034e-05 / 1.4197658969421668e-05 0.009364 5 123 KHDRBS1_2 0.0000000015 1.6169392314406466e-05 / 0.0039056626487888758 / 0.0034273259551571168 / 0.03391386466641536 / 0.011666948417914267 9.514267607742899e-13 / 2.8566604252327994e-07 / 7.517707711246514e-07 / 4.1751581964055053e-07 / 9.055789447982931e-07 0.010586 5 124 E2F6_3 0.0000002841 0.0022254132117215356 / 0.0037188790361072878 / 0.005458005465302464 / 0.0014398907128301208 / 0.04086571019880003 4.421453475946776e-08 / 1.5392585786553033e-06 / 0.0003430693964816855 / 1.779882292403961e-06 / 0.0002956989113369879 0.010742 5 125 ELL2_2 0.0000000202 0.00011694820055399171 / 0.029386513254453968 / 0.005657975920541809 / 0.028459156083205858 / 0.01406740315871594 8.347517785439741e-08 / 1.2698717079911781e-06 / 1.917338652438103e-05 / 0.0001196727478086908 / 2.0681105855800244e-05 0.015538 5 126 BSN_2 0.0000022389 0.000506059688566897 / 0.04616500613759174 / 0.012649170673498711 / 0.005186853257558283 / 0.02830343719752466 5.0173732858781275e-06 / 1.1005994245083331e-07 / 0.00024710770557642556 / 0.00048732984216352446 / 0.00023929723037045147 0.018562 5 127 ATG4A_5 0.0000000000 4.475035366083391e-06 / 9.946560976238241e-06 / 1.150460981566587e-06 / 6.699525372343991e-05 2.070885361738112e-08 / 3.791151058200872e-07 / 2.8872435045296478e-08 / 0.00012711434042399471 2.06E-05 4 128 CD44_4 0.0000000000 4.4784520790283526e-08 / 2.3008815242152554e-05 / 5.2052109653188956e-05 / 0.00014533006515361492 7.884191479096678e-08 / 2.9710643899587148e-06 / 1.5781437020851443e-06 / 6.210975626614534e-07 5.51E-05 4 129 GSN_5 0.0000000000 3.785922406236843e-10 / 3.0058719101012673e-05 / 0.00029646205587575313 / 6.646730266541163e-05 8.816984894077637e-10 / 2.2588865060721033e-06 / 7.88507208198445e-05 / 4.284376587003957e-05 9.82E-05 4 130 CD99_5 0.0000000000 2.0149183113126577e-05 / 0.0006745061120899554 / 0.0002998852328395526 / 0.0001242923271196099 3.1338403532472386e-09 / 0.0006507487844929586 / 5.172267401380639e-06 / 9.968659271858592e-06 0.00028 4 131 GNAI2_5 0.0000000000 0.0005584151279765244 / 0.0003249499378752368 / 4.745051251091654e-05 / 0.00030759784724731154 4.982873808104418e-08 / 9.650800047119655e-07 / 2.454295952727384e-07 / 9.904904324446315e-05 0.00031 4 132 DDX60_5 0.0000000000 2.9212913515461393e-06 / 0.0001530409063220267 / 0.0003993610031162385 / 0.0010695426477561165 7.01839699594606e-08 / 2.0329686030779097e-06 / 1.4613415440657328e-05 / 1.702607599935211e-05 0.000406 4 133 MICALL2_3 0.0000000000 4.697595022472674e-06 / 6.457501817223296e-05 / 0.0015363886875154054 / 0.00014385763146450997 1.7875525723925519e-06 / 1.642694121565277e-07 / 1.8052618402003836e-05 / 5.8265193908577595e-05 0.000437 4 134 SOAT1_5 0.0000000000 0.001922385896174513 / 1.924383271682602e-06 / 2.782774586423633e-06 / 3.555527535100237e-05 7.936734231102217e-07 / 6.625132467195288e-08 / 5.379303522414254e-07 / 2.3383986457320025e-06 0.000491 4 135 PLEC_1 0.0000008789 4.778480179883678e-05 / 0.0006110060061203364 / 8.712601577854501e-09 / 0.0014562282237067896 2.8277390114780423e-07 / 2.166203983124237e-06 / 1.5583735231329512e-07 / 2.7125361005219603e-06 0.000529 4 136 XRCC5_1 0.0000000924 1.384655004104117e-06 / 0.0006273187563236247 / 2.098169823270148e-06 / 0.0014863302195178008 2.6130050369275158e-06 / 2.132206160555519e-05 / 2.4237849248550327e-06 / 0.00030699349223093454 0.000529 4 137 OSGEPL1_1 0.0000001116 0.00028286232014178015 / 0.00037839447623271325 / 0.001443320215490813 / 0.00010681753824403367 3.604572142413008e-06 / 4.082064229081972e-06 / 3.18593215315723e-06 / 9.670676646757636e-07 0.000553 4 138 TMEM97_4 0.0000000000 0.00018650020835883543 / 0.0004347886633272347 / 4.502684569031259e-06 / 0.0016700457783649062 3.3084881992489725e-06 / 4.754536166762309e-06 / 1.3093900089996567e-06 / 5.225302868715506e-05 0.000574 4 139 GLIS3_4 0.0000000000 0.0002286645360176498 / 0.0006619438558324503 / 0.0016620049728346326 / 1.1074671736457553e-05 1.510316419391924e-06 / 3.2409409252278102e-06 / 9.224875739627753e-05 / 1.930014755272634e-05 0.000641 4 140 ANXA1_5 0.0000000000 5.8551591866382045e-05 / 3.45022524746413e-05 / 6.004993403577111e-08 / 0.002751213558972749 2.397154304313467e-07 / 3.176106815413732e-06 / 6.107114335334353e-07 / 1.2210016577494943e-05 0.000711 4 141 FAM120A_5 0.0000000001 0.0026813412993839337 / 0.0005742956528301279 / 3.563997625540032e-05 / 8.528922868820983e-06 0.0001881828357253321 / 0.00012537124618201126 / 1.3817216627076195e-05 / 0.00011563779547673361 0.000825 4 142 SAFB_3 0.0000000001 0.001211277784043611 / 0.00011818878635236698 / 0.00029246473195964197 / 0.001769841813108865 7.668444452032125e-07 / 2.898461734945786e-07 / 2.8130419096127126e-05 / 0.00035040496082839104 0.000848 4 143 ACTN4_4 0.0000000000 1.4106395746220967e-05 / 8.221349715218104e-05 / 0.003449453406084509 / 0.0001267717634392765 3.3938237122738275e-07 / 1.2062404978268685e-06 / 4.0239968184075355e-06 / 2.990385220556594e-05 0.000918 4 144 FAM117B_5 0.0000000000 0.00014565693019513351 / 0.0006387724048262495 / 2.041989162397474e-07 / 0.00308065083431233 1.2462660948443544e-05 / 4.0378352806812125e-06 / 4.5557593081500904e-08 / 6.255861262356289e-05 0.000966 4 145 TSSC1_1 0.0000008042 0.0010281262291342236 / 0.0008973831238703076 / 0.0014311836039126026 / 0.0005658979552839525 4.773040777006663e-07 / 1.293648273273451e-06 / 1.370737279606987e-06 / 6.872239294614834e-08 0.000981 4 146 SERPINE2_1 0.0000006237 8.712601577854501e-09 / 0.003917317274808632 / 4.778480179883678e-05 / 0.0006110060061203364 4.293656906359287e-09 / 7.59699887090359e-07 / 2.4805326670497096e-06 / 2.6318189672753774e-06 0.001144 4 147 IFNAR1_5 0.0000000000 1.6950082284852724e-05 / 0.00023259440421303834 / 2.145061357704084e-05 / 0.006168307042686711 2.6777259205549025e-06 / 3.126328063081149e-07 / 1.6378968792487728e-05 / 1.980502151445686e-05 0.00161 4 148 UEVLD_3 0.0000000002 0.0025817513756711884 / 0.0002058200859707558 / 0.0001532402705811572 / 0.003951386408683102 1.7719417389393089e-06 / 1.5327037128336517e-08 / 5.132415043139141e-08 / 8.649188479247404e-07 0.001723 4 149 GUF1_5 0.0000000000 5.893107805476978e-05 / 0.007964457709027949 / 4.303196745477378e-05 / 2.6967345038980607e-05 3.970170459579241e-07 / 2.864249504984967e-06 / 3.435012765675232e-07 / 1.5389318932784949e-06 0.002023 4 150 GBP3_1 0.0000015823 0.0019027179320774803 / 0.0003168019030192227 / 0.004613449756294485 / 0.0012733956455115425 1.8104358020946005e-07 / 2.2473742888087726e-07 / 3.977899627306711e-05 / 5.118490443586335e-06 0.002027 4 151 MED28_1 0.0000032077 0.0003168019030192227 / 0.0019027179320774803 / 0.004613449756294485 / 0.0012733956455115425 2.9684923703899697e-07 / 6.654843522911474e-07 / 3.1176140675136144e-06 / 3.225376490885068e-06 0.002027 4 152 SLC2A10_1 0.0000000972 0.0019027179320774803 / 0.0003168019030192227 / 0.004613449756294485 / 0.0012733956455115425 1.7631746614895863e-07 / 2.4782620652363583e-09 / 6.763392837610305e-07 / 2.321466389902454e-06 0.002027 4 153 CBR3_1 0.0000000238 0.0003168019030192227 / 0.0012733956455115425 / 0.0019027179320774803 / 0.004613449756294485 7.910872738545078e-09 / 1.4202365174097019e-08 / 5.43796956141398e-07 / 4.674686520121403e-05 0.002027 4 154 HIC2_1 0.0000007789 0.0019027179320774803 / 0.0012733956455115425 / 0.004613449756294485 / 0.0003168019030192227 3.0633550655698566e-10 / 2.1696779182322382e-09 / 2.2828231685954628e-07 / 2.4650085263362296e-06 0.002027 4 155 IGSF9_1 0.0000004185 0.0012733956455115425 / 0.0003168019030192227 / 0.004613449756294485 / 0.0019027179320774803 3.3765982883653153e-06 / 2.559009185958782e-07 / 1.2961469049521693e-06 / 8.135407791689286e-05 0.002027 4 156 RCAN1_1 0.0000010839 0.0019027179320774803 / 0.004613449756294485 / 0.0012733956455115425 / 0.0003168019030192227 3.52499926166527e-09 / 1.4195702150916024e-07 / 2.8012155247278448e-06 / 8.591081719368746e-08 0.002027 4 157 SAFB_1 0.0000022906 0.004613449756294485 / 0.0019027179320774803 / 0.0003168019030192227 / 0.0012733956455115425 1.2527049345521191e-06 / 1.2341574556015853e-07 / 4.073201704051311e-08 / 5.976596803731563e-06 0.002027 4 158 HNRNPA0_2 0.0000000370 0.0009389452362024158 / 0.0004583304262309702 / 2.0318525623421967e-06 / 0.006886174737452949 6.591983136046331e-08 / 2.1078089903628105e-05 / 2.1991513327880328e-05 / 6.211957230218145e-05 0.002071 4 159 ISL1_1 0.0000000008 0.0014562282237067896 / 8.712601577854501e-09 / 4.778480179883678e-05 / 0.008799197542964286 4.47926130890511e-10 / 1.3159792563051542e-10 / 1.6267903098803325e-06 / 8.859331058014511e-06 0.002576 4 160 PPIC_1 0.0000008150 1.1499890891595663e-06 / 0.0023486428669150803 / 0.004509729888699788 / 0.003649857824379229 6.181851966897516e-08 / 4.336126091570401e-07 / 1.130291682742051e-06 / 5.702819528263402e-06 0.002627 4 161 CBX1_1 0.0000073072 0.00920357999307954 / 0.00020520490391129044 / 0.0014863302195178008 / 2.098169823270148e-06 3.4308469313672e-05 / 0.00016072496067379242 / 0.000416531131321131 / 1.1909250396666738e-05 0.002724 4 162 ARID3B_1 0.0000039314 0.0012733956455115425 / 0.0019027179320774803 / 0.004613449756294485 / 0.0034947768260440494 5.689363226662423e-09 / 3.5223565854980375e-06 / 2.7692513603614087e-06 / 7.767239795505205e-06 0.002821 4 163 RNF157_1 0.0000017210 0.004531342266561176 / 0.0026490796375761676 / 0.0016555906467057811 / 0.0030838618137353662 1.0799957008656176e-05 / 7.097149358472166e-05 / 4.819541314832769e-07 / 7.676415694714317e-07 0.00298 4 164 EIF3L_2 0.0000000102 0.005135657485519335 / 0.005326745976664332 / 0.0017435819308224765 / 7.384136449790188e-06 1.8190521073639574e-10 / 1.0527503241568249e-06 / 4.518548487460203e-06 / 1.3638553131166296e-06 0.003053 4 165 SLC25A43_2 0.0000000002 0.00014847770954858836 / 0.0010357469368733494 / 0.0010144217502109298 / 0.010259629272911746 3.357035874085631e-07 / 7.382332140811268e-07 / 2.131827740313582e-06 / 3.004944425021926e-05 0.003115 4 166 OLFML2A_1 0.0000000021 0.0014562282237067896 / 8.712601577854501e-09 / 0.0006110060061203364 / 0.010748894710017389 1.2437444351849456e-10 / 1.877118300185312e-10 / 1.270455283512457e-06 / 1.2117974236888312e-06 0.003204 4 167 HNRNPA1L2_4 0.0000000000 3.055750323559003e-05 / 0.013700253988565498 / 3.881898534012908e-05 / 4.532481843678641e-08 9.763383363669304e-09 / 6.413557230739407e-06 / 1.1996173334605904e-08 / 2.6326526346171393e-08 0.003442 4 168 GPR125_1 0.0000015939 0.0004338260851758113 / 0.005078710464709388 / 0.005770181686062503 / 0.0025299472548494955 8.375396341394661e-06 / 1.2620826876929007e-07 / 5.037605201133463e-06 / 4.397437068329601e-06 0.003453 4 169 HFM1_5 0.0000000000 4.6027629362357145e-06 / 2.054289713438471e-06 / 0.010747113861164049 / 0.0030735298911349954 5.2804634950801046e-08 / 1.3823733955490087e-07 / 0.0002289318652341564 / 0.00017922188693161184 0.003457 4 170 FAM161A_3 0.0000000004 1.1900765556084342e-06 / 6.104336159313168e-05 / 0.0038692378656813085 / 0.010450418229319037 7.836775108119704e-06 / 4.602994442160525e-06 / 0.0014084623238924201 / 0.006437120167388166 0.003595 4 171 MYO1E_5 0.0000000000 9.1301369378943e-07 / 3.6970513366191076e-05 / 0.014560624799721568 / 0.00044473645621912025 1.563633164899415e-07 / 6.6703997984050774e-06 / 0.0002544952895081012 / 1.2369712374983664e-06 0.003761 4 172 BHLHE40_2 0.0000000008 0.0033273695719493366 / 0.0003451393798156882 / 2.1541055929197527e-08 / 0.012364148039779468 3.6750231825447993e-09 / 1.3797224307526888e-10 / 4.5238117998428525e-10 / 1.4503164618207844e-05 0.004009 4 173 IPO9_1 0.0000001864 0.00706078944078839 / 6.392429369799613e-05 / 0.0011036487237694873 / 0.008158453075892491 7.925030915673659e-07 / 2.436316843178784e-07 / 2.7933385967164893e-06 / 3.7162081746516914e-06 0.004097 4 174 MALT1_5 0.0000000000 8.286399528571891e-06 / 0.0002461865995006486 / 0.00023833137981344143 / 0.016843325771737905 3.375997586023991e-08 / 1.2071446047409586e-07 / 1.095602481975961e-06 / 2.6082135535498982e-06 0.004334 4 175 GDPD1_1 0.0000033642 0.008597087236259153 / 0.002859168680149655 / 0.0007069744136606002 / 0.005851685675009941 9.233213274811235e-08 / 3.5536116052273754e-07 / 2.1037456632604637e-07 / 1.3670539309103289e-05 0.004504 4 176 CLIC1_5 0.0000000000 0.00048798421080350877 / 0.003091093830161087 / 0.005843494432330533 / 0.008851783624153233 3.133239901460721e-08 / 1.3305262196278536e-08 / 4.3396495831301414e-05 / 1.8259140204877226e-06 0.004569 4 177 GBP1_1 0.0000000190 0.00029139375190295606 / 0.008770410107355643 / 0.009220967328515883 / 7.763485144629643e-05 2.034005959874992e-08 / 1.025777265986079e-05 / 3.7717113262051256e-06 / 6.322665753334008e-05 0.00459 4 178 WDR1_4 0.0000000063 0.00018307154229595032 / 0.0002457066480750095 / 0.0005563718559501817 / 0.01757082718712336 1.4158768736111935e-07 / 1.8926145330443176e-07 / 3.145940065328651e-05 / 2.00918389447038e-06 0.004639 4 179 NOLC1_1 0.0000002124 0.005497026258977277 / 0.0037411319458859455 / 0.001569082671062799 / 0.009893561180811163 1.0104488773237543e-08 / 7.714332997539589e-07 / 2.1884817904926247e-06 / 3.370149988961001e-05 0.005175 4 180 SUCLG2_1 0.0000002256 0.0008973831238703076 / 0.0060047412034100744 / 0.013949817553702996 / 3.679473658399758e-05 4.6445581997855444e-07 / 0.00013589105082118295 / 6.517922811200161e-07 / 3.2332580875235436e-06 0.005222 4 181 TMEM50B_4 0.0000000000 0.00021033920160836247 / 3.048709751971941e-06 / 7.4963019248993875e-06 / 0.02190343894897618 4.260473533327541e-07 / 3.0953447432169544e-06 / 1.0406702632518272e-05 / 6.714065008670566e-05 0.005531 4 182 TEP1_2 0.0000000008 0.00044390649641880996 / 0.00022291138567452008 / 0.007728913610011587 / 0.013802397731305673 7.69344257098905e-08 / 7.583371932539051e-07 / 1.1452916356973667e-05 / 1.4951877455973638e-05 0.00555 4 183 C1QTNF4_1 0.0000065502 0.018168011703420802 / 0.0008739549079227278 / 0.0021525218115003323 / 0.001823497355076137 1.4609518924208137e-05 / 1.9886833860209337e-08 / 3.327674138498291e-05 / 4.1425752762924387e-07 0.005754 4 184 SAMD9_2 0.0000000241 0.00015888299030502074 / 0.0005649656249134306 / 0.02294011174111297 / 2.9781970809395596e-05 1.4515338714501776e-07 / 1.0069662929413845e-06 / 3.079017964078163e-05 / 2.9239260560336778e-06 0.005923 4 185 INTS2_1 0.0000015748 0.0071423807687498436 / 0.005409509534570436 / 0.012055857526605073 / 1.7711409436331332e-05 3.636941582614834e-06 / 8.403767627067496e-07 / 0.000275721623498196 / 3.367956926486663e-05 0.006156 4 186 FUBP1_1 0.0000511078 0.00130787641161479 / 0.004251874133389083 / 0.003364552119188696 / 0.015851508245258043 1.9108608392104508e-07 / 2.9841202780652124e-07 / 5.350933661523097e-06 / 2.1932160234548787e-07 0.006194 4 187 RPAP1_1 0.0000410735 0.02301236512624726 / 0.0005345944155461007 / 0.001243129263120806 / 0.00047465333000177624 3.176104797820964e-07 / 2.5190175338691726e-06 / 2.1523203092437045e-06 / 9.149396149972693e-07 0.006316 4 188 HEXB_1 0.0000076128 0.015529327313804105 / 0.0013546126949011356 / 0.0060782790336966815 / 0.0035812987621354486 6.42491318793146e-10 / 4.577473133930505e-08 / 3.39530943939453e-09 / 2.7122303773993426e-06 0.006636 4 189 HNRNPU_1 0.0000032015 3.772462305351297e-05 / 0.00064922210107833 / 0.0010438255846085224 / 0.026018704719089503 1.000463952367771e-07 / 2.638911239632533e-07 / 7.660492345043258e-07 / 4.407301801134979e-06 0.006937 4 190 FUCA1_2 0.0000000004 7.228979888741317e-05 / 0.013714832441879614 / 0.007971606520234983 / 0.007402461335311882 2.0988769570938153e-06 / 1.9872137311126255e-06 / 3.537000242989197e-06 / 9.575754350455543e-05 0.00729 4 191 NOTCH2_2 0.0000000072 0.006230846374778002 / 0.003851986494620127 / 0.0034437522016521897 / 0.015866838196212218 1.4454100512704434e-07 / 8.519702743163462e-07 / 9.796096746463353e-06 / 3.089459803795722e-05 0.007348 4 192 CCT4_1 0.0000020961 0.0004974933526793384 / 0.008397433522606995 / 0.008173144283430401 / 0.012491622786737646 2.7241251268074896e-08 / 1.4220454346358598e-06 / 8.270539706935099e-07 / 7.806294817192854e-06 0.00739 4 193 UTRN_3 0.0000000000 2.360823500030083e-06 / 4.819891610542341e-05 / 0.01459161774480625 / 0.01624353394689184 9.96939171389334e-09 / 5.260467316300094e-07 / 3.5243167304031697e-06 / 9.884600038679634e-07 0.007721 4 194 CALU_1 0.0000004164 8.712601577854501e-09 / 0.029987683740818265 / 4.778480179883678e-05 / 0.0014562282237067896 5.266009225225312e-10 / 4.0454271359773727e-07 / 7.672203291248733e-08 / 5.85093501886766e-06 0.007873 4 195 PLAUR_1 0.0000000244 8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896 / 0.029987683740818265 8.615162127229272e-11 / 9.681579901416002e-07 / 1.4437165409807745e-06 / 9.35433381095111e-06 0.007873 4 196 HIST1H3F_2 0.0000000051 0.0015927321289850582 / 0.023851866632585955 / 0.00016090253762067176 / 0.006218991828298577 2.1956145641009148e-08 / 0.00010324111552331347 / 6.744350520658004e-06 / 6.501852523462225e-05 0.007956 4 197 SHF_2 0.0000000138 0.001693689356850199 / 0.0014031215699221884 / 0.012735358967208718 / 0.017175407042679062 1.935898724207595e-07 / 7.846392075982059e-07 / 9.678320481712436e-06 / 8.427515550712705e-07 0.008252 4 198 CERK_1 0.0000008873 0.013244448613132145 / 0.0022351613397075614 / 0.015474072817082456 / 0.0029744892448975834 0.00020051688200258856 / 0.00018492952950495273 / 0.0012280052280709938 / 0.0005416554989378981 0.008482 4 199 TADA1_1 0.0000002147 0.016780696985377475 / 0.0005695162353950492 / 0.009231171890260521 / 0.00772762240557102 1.4508371309511671e-08 / 6.435719575006254e-08 / 4.82397274391162e-08 / 2.779770649698667e-07 0.008577 4 200 UBA7_1 0.0003624359 0.0005728902408745853 / 0.003242823752914826 / 0.0027568341257606386 / 0.03172797440821663 4.377541835767184e-08 / 1.4020761197150485e-06 / 2.9401803878641854e-05 / 6.058178438606368e-07 0.009575 4 201 SETDB1_1 0.0000003780 0.0026490796375761676 / 0.0030838618137353662 / 0.0004052971561229435 / 0.03955358967054088 5.084831070504725e-08 / 1.5437307336972335e-08 / 2.4314077044074555e-08 / 3.708419532637195e-06 0.011423 4 202 FEV_1 0.0000018489 0.033538144332397844 / 0.00028614552404424633 / 0.01249350392911133 / 5.910503776729101e-05 3.513392334373485e-06 / 3.0193991188193814e-06 / 4.261681658726496e-06 / 3.904348041550831e-06 0.011594 4 203 PLIN3_1 0.0000052675 0.00029139375190295606 / 0.009220967328515883 / 0.03147989324458417 / 0.008770410107355643 4.751419536263273e-07 / 1.5878609213360564e-06 / 2.5660205514983566e-05 / 1.1850407245136544e-05 0.012441 4 204 CAPZB_1 0.0000074431 0.020797363705116343 / 0.0062029903117365925 / 0.01708229147040032 / 0.012228646417111324 3.430820753789497e-07 / 7.116750242001532e-06 / 1.9457058230691574e-05 / 1.4739355201517365e-06 0.014078 4 205 PRR14L_1 0.0000287853 0.025082579510674555 / 0.0002021790532799894 / 0.012782548244800053 / 0.01903033340546255 3.0568724876555808e-06 / 1.7592986743744327e-05 / 0.0003036464804643225 / 9.900533456095719e-05 0.014274 4 206 SYT4_1 0.0000045133 0.015545833082593517 / 0.02041517410701112 / 0.005606155017185667 / 0.023315264256491483 0.0007991296587415927 / 1.5782237178697584e-07 / 3.4514435206822334e-06 / 3.6363448556754176e-05 0.016221 4 207 OSTM1_1 0.0000004769 0.00029139375190295606 / 0.014437131210731376 / 0.008770410107355643 / 0.042521980850760616 1.8325191636828767e-09 / 1.7933002396456563e-06 / 1.209386955631816e-05 / 2.8665654575872185e-06 0.016505 4 208 ALKBH2_5 0.0000000000 0.0006658217635395392 / 6.408084768025853e-06 / 0.04987195778126702 / 0.025098765971631444 1.084736492711166e-08 / 9.593642946100947e-08 / 1.132197770977069e-05 / 2.191320769137121e-05 0.018911 4 209 MSN_1 0.0000002383 0.01695446499444467 / 0.027498564129629463 / 0.014675290351873422 / 0.018771777160462803 4.599537647191073e-06 / 1.9086619291135215e-05 / 4.8131935092059315e-06 / 1.3273993329378002e-05 0.019475 4 210 ESYT2_2 0.0000000013 0.0030336578784421852 / 0.01671859601940339 / 0.015226777755356039 / 0.04496562784687137 3.165663675076115e-09 / 2.3423418225839996e-05 / 5.032307286753409e-07 / 1.2411450689986321e-05 0.019986 4 211 RSBN1_1 0.0000185080 0.03683753470884825 / 0.011413935706631708 / 0.017145541610166553 / 0.014660785392642973 1.433152382574118e-07 / 5.910344738541638e-08 / 2.5220601123022208e-05 / 4.2656913152557095e-06 0.020014 4 212 ATL3_1 0.0000008573 0.011413935706631708 / 0.014660785392642973 / 0.017443397981769932 / 0.03683753470884825 2.938478701650645e-07 / 1.2357184821505046e-06 / 1.34699746919262e-06 / 4.381675501436861e-06 0.020089 4 213 GLCCI1_2 0.0000000339 0.000506059688566897 / 0.006967423038249733 / 0.04616500613759174 / 0.02830343719752466 2.756128143638523e-10 / 8.727903434920509e-10 / 5.197443718190881e-07 / 0.00016721014291291134 0.020485 4 214 STX4_1 0.0000103251 0.017443397981769932 / 0.017145541610166553 / 0.03683753470884825 / 0.011413935706631708 1.149596541548471e-07 / 9.1652846360952e-06 / 2.8282830819547243e-06 / 3.479429274497365e-07 0.02071 4 215 ZFP36_1 0.0001056505 0.017443397981769932 / 0.017145541610166553 / 0.011413935706631708 / 0.03683753470884825 1.737842213973009e-07 / 8.045110852931203e-06 / 6.077495271342403e-05 / 1.3331815375742793e-06 0.02071 4 216 ITPR3_1 0.0000001347 0.04001855602158032 / 0.02473369613058651 / 0.002494297125613762 / 0.017644496874256163 3.1111051486214713e-07 / 3.1246898169649434e-07 / 5.066474066266959e-07 / 6.524401461141414e-06 0.021223 4 217 APEX1_1 0.0000125684 0.029245906890336886 / 0.039756863847419444 / 0.012044249045532097 / 0.005547335178190005 7.501855120464028e-09 / 2.210591549312696e-06 / 0.0010048532388054296 / 7.598158853857719e-07 0.021649 4 218 NAGK_1 0.0000090434 0.0359209982666861 / 0.02283925689865032 / 0.03203446148966057 / 0.007869203029856895 4.857892768176024e-12 / 1.5321698605219521e-06 / 3.1094588442870684e-07 / 1.03713103228835e-07 0.024666 4 219 CTSO_2 0.0000000001 0.011266491236640721 / 0.04019864979524411 / 0.009925247376618809 / 0.049822690026412035 3.138972714567624e-08 / 1.560503101825122e-08 / 9.567048792824493e-06 / 1.998510033084769e-06 0.027803 4 220 GAL3ST3_5 0.0000000000 1.4966990682807468e-07 / 2.827249605742276e-06 / 3.1413408717447276e-05 3.0226583395773654e-07 / 4.251989568762905e-06 / 9.932757607291931e-07 1.15E-05 3 221 UBA52_3 0.0000000000 1.3603516623392527e-05 / 6.029043389123571e-05 / 5.045497445639472e-05 5.851551410932261e-07 / 1.710172873999253e-08 / 1.2158482126235317e-05 4.14E-05 3 222 MSRB3_4 0.0000000000 6.46451222732421e-05 / 3.720566971124837e-05 / 8.695780204681589e-05 7.267015459944046e-07 / 4.887970470660509e-05 / 6.751019417131056e-05 6.29E-05 3 223 MTPAP_3 0.0000000001 2.4720937454568888e-05 / 1.2751616501556023e-05 / 0.00018587383065277118 4.2193212858195527e-07 / 3.403424981067467e-07 / 1.255056828139161e-06 7.44E-05 3 224 UBE2O_4 0.0000000000 0.00020771366206680562 / 1.528305625592724e-05 / 1.5417123239589966e-05 8.204970746839372e-07 / 1.2473665471568327e-05 / 2.207999415422632e-05 7.95E-05 3 225 RANBP17_1 0.0000004613 0.00013057839781136293 / 2.098169823270148e-06 / 0.00012418009082273935 1.5462113719102461e-06 / 1.0841250457737996e-05 / 0.0007974404623478325 8.56E-05 3 226 ZNF516_4 0.0000000000 3.872664033406607e-06 / 0.00012352623655085027 / 0.00014080284226678161 8.633851745836879e-06 / 3.646126773929292e-05 / 4.693534198442505e-05 8.94E-05 3 227 NKAIN1_3 0.0000000000 6.048904209077932e-07 / 0.0002827019572692268 / 4.565055181871741e-06 1.8963600971928307e-07 / 2.4597415093902517e-05 / 8.312648483856273e-05 9.6E-05 3 228 DHX9_3 0.0000000000 0.00031618213746396326 / 1.5079640407764188e-07 / 3.878104391115258e-05 7.324325851139409e-08 / 8.345673558891845e-07 / 5.455940168964712e-06 0.000118 3 229 TET1_4 0.0000000000 7.04443145456897e-05 / 0.00013097208813100302 / 0.00017715535475236788 7.420704863880182e-07 / 1.871920932527521e-06 / 1.2498158253814596e-06 0.000126 3 230 UHMK1_1 0.0000020860 0.00030051214168214937 / 6.606509042863372e-05 / 9.390951294242489e-05 5.795453634595254e-08 / 9.135482956883646e-09 / 5.202287615781549e-07 0.000153 3 231 KCNH8_2 0.0000000000 6.395893878746714e-08 / 0.0004951577945428809 / 6.246855784844429e-05 1.8797523362973878e-08 / 4.636654129462014e-07 / 1.099671115182553e-06 0.000186 3 232 PMEL_1 0.0000005663 2.098169823270148e-06 / 1.384655004104117e-06 / 0.0006273187563236247 6.845101785005541e-09 / 2.3534233465189457e-06 / 7.679394256913984e-07 0.00021 3 233 TMEM177_2 0.0000000000 0.000218258066644831 / 2.729001089528698e-05 / 0.0005268025057445726 5.209193027162048e-08 / 7.210516358215353e-07 / 8.65292135655517e-06 0.000257 3 234 P4HB_3 0.0000000000 7.235087963937188e-05 / 0.00020977095849751892 / 0.0006140291296563689 1.5481316963269385e-06 / 1.2667727790601262e-05 / 2.2318101021362054e-05 0.000299 3 235 GLB1_2 0.0000000001 0.0008060555543976513 / 0.00015263556465626687 / 0.0002492824297492718 5.95245025264109e-07 / 3.0646460084359855e-06 / 2.0252846047441925e-05 0.000403 3 236 NIPSNAP1_5 0.0000000000 7.0049869888978436e-06 / 0.0005153457051148798 / 0.0006955168425803274 1.5111991034910146e-07 / 1.7955354168874533e-06 / 6.9569188414230535e-06 0.000406 3 237 STOX2_4 0.0000000003 4.1961269753906035e-05 / 0.0010880952015806498 / 0.00010503474822771901 8.316576707748038e-07 / 1.514815251496678e-05 / 3.9477756451806046e-06 0.000412 3 238 HIC2_5 0.0000000000 4.726033274744903e-06 / 0.00013382198113446112 / 0.0013349789650252575 9.611997971680818e-09 / 1.1620332716585593e-05 / 3.9355477345741505e-05 0.000491 3 239 DDX25_1 0.0000003731 8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896 1.6097112876531916e-08 / 3.2052124199850265e-08 / 1.4170604850554317e-07 0.000501 3 240 DNMT3A_1 0.0000003165 8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05 3.5247387941347504e-08 / 6.731804150774537e-06 / 1.2896794234236179e-05 0.000501 3 241 EXT2_1 0.0000003436 8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05 2.0783635717550663e-12 / 9.054121086432515e-07 / 2.0219531513922313e-05 0.000501 3 242 FAM129B_1 0.0000000190 8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896 6.60672131957345e-08 / 5.537377478544649e-08 / 4.1732948235118237e-07 0.000501 3 243 GINM1_1 0.0000002753 8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05 5.046050215569822e-09 / 5.428070521726932e-08 / 2.1701147223144043e-06 0.000501 3 244 HNRNPA1L2_1 0.0000000756 8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896 1.2976171138488909e-09 / 4.5877377333254656e-07 / 1.6836213911883948e-06 0.000501 3 245 MAN1B1_1 0.0000001522 8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05 3.0241063676746706e-11 / 1.5906368364620238e-09 / 1.318311055073274e-07 0.000501 3 246 TACC1_1 0.0000024323 0.0014562282237067896 / 4.778480179883678e-05 / 8.712601577854501e-09 6.120199026321514e-07 / 4.1123437302256347e-07 / 1.0614723925305345e-08 0.000501 3 247 RIPK1_5 0.0000000000 6.840228317523313e-05 / 0.0009512875629473391 / 0.0005924452898671693 1.5712671052120772e-06 / 4.09648566039462e-06 / 3.7135622189006208e-06 0.000537 3 248 ZBTB4_3 0.0000000000 0.0005037641948066041 / 4.1029029786791e-05 / 0.0011809756046229313 1.117525634308104e-05 / 2.721755300189734e-07 / 5.303486617820998e-05 0.000575 3 249 TLN1_5 0.0000000000 1.9703021048281005e-05 / 0.0005523542769980133 / 0.001186882005547644 2.022661269835003e-07 / 7.938143861075808e-05 / 8.872728066213042e-06 0.000586 3 250 PCBP3_1 0.0000002605 8.712601577854501e-09 / 0.0006110060061203364 / 0.0014562282237067896 7.776240359663578e-08 / 1.638864761384365e-06 / 1.2093871604348117e-06 0.000689 3 251 KIDINS220_2 0.0000000000 0.0018859337356087994 / 0.0001930893136831812 / 4.710776942634132e-06 5.072414419210524e-06 / 1.9800037664169994e-06 / 3.568737378774764e-05 0.000695 3 252 MYH9_4 0.0000000000 0.0011716362540399527 / 2.5874889458489842e-05 / 0.00098592835353018 1.1606044222659936e-05 / 5.315659303841256e-07 / 0.0002008409108671274 0.000728 3 253 C2orf43_4 0.0000000000 5.393578869543922e-07 / 0.0023453445326236527 / 1.354525793237082e-06 6.595211500412567e-08 / 3.985671655723259e-07 / 6.693718279433329e-07 0.000782 3 254 CFLAR_5 0.0000000000 2.366050283623384e-07 / 1.8250670479244966e-06 / 0.0026884317876910953 4.986931710131805e-06 / 3.457834181885606e-06 / 1.5979548021423277e-06 0.000897 3 255 RAB27A_5 0.0000000000 4.235470787154264e-07 / 0.00048364115746124477 / 0.002294886679155574 1.5348969527407146e-08 / 1.8046897740630015e-06 / 4.1788406415060826e-05 0.000926 3 256 PLSCR4_2 0.0000000029 4.859413804591664e-05 / 0.0027548209719256856 / 0.00020561631972662475 3.3117537208770918e-09 / 1.148805004150062e-06 / 4.664969309642537e-06 0.001003 3 257 RPUSD4_1 0.0000007330 0.001066805887839933 / 0.0005152101842532016 / 0.0015298583359982347 2.3615410532322286e-05 / 4.319838908046999e-06 / 0.0002330489716331065 0.001037 3 258 MPST_3 0.0000000016 0.00013736583753548478 / 0.0030443962453463847 / 8.033145753215765e-06 3.289559261620218e-06 / 3.976886270875369e-06 / 1.171567023312239e-06 0.001063 3 259 MSN_1 0.0000002015 0.0019027179320774803 / 0.0012733956455115425 / 0.0003168019030192227 9.67855150073715e-08 / 3.184222031943731e-08 / 4.6792815745596373e-07 0.001164 3 260 TGFB1I1_1 0.0000000689 0.0012733956455115425 / 0.0003168019030192227 / 0.0019027179320774803 9.602262969345956e-07 / 1.898080280214667e-06 / 4.85147907436071e-06 0.001164 3 261 PRMT1_2 0.0000000003 2.8649381309321584e-06 / 0.00013104001909797732 / 0.00341452788547584 3.7442073966474697e-11 / 2.696236533103196e-06 / 4.175789992611833e-06 0.001183 3 262 AGPAT3_3 0.0000000000 0.0009240199113069562 / 0.001726211324732259 / 0.0009222051384671301 1.4076606607890667e-05 / 6.064432655122854e-06 / 0.00046211741435037205 0.001191 3 263 NUPR1_2 0.0000000008 1.2731341624968911e-05 / 5.8997927541035875e-06 / 0.003561757705418032 6.730910090199648e-07 / 2.3445593630205304e-06 / 1.3063148311515809e-05 0.001193 3 264 RNPC3_2 0.0000000375 0.0025602598027028244 / 5.469917899643988e-05 / 0.0010104633264639477 1.393467985718326e-06 / 7.829150593953611e-07 / 0.00010845460486238517 0.001208 3 265 S100A6_2 0.0000000006 0.0033273695719493366 / 0.0003451393798156882 / 2.1541055929197527e-08 1.7609429749647884e-07 / 5.870724758098998e-07 / 1.1681749490132842e-07 0.001224 3 266 GADD45B_2 0.0000000000 0.00010634683697229356 / 0.003790365456096317 / 1.8397621446509385e-05 1.705317052907576e-07 / 8.878912678862584e-06 / 2.2556761049368962e-07 0.001305 3 267 IRF2_2_5 0.0000015405 0.0008574554508689445 / 0.003180287587180633 / 6.994095656900796e-05 9.872538086030946e-08 / 1.5355274708245824e-06 / 2.245172851097339e-06 0.001369 3 268 MVP_2_3 0.0000000046 0.00024759203487775524 / 1.1168409277359634e-06 / 0.004671632294386495 1.4353154937155882e-08 / 5.633740184888267e-07 / 7.385772453731096e-05 0.00164 3 269 GTF2H5_2 0.0000000066 0.0002128703129063878 / 0.002908963894359682 / 0.0018958315428404735 5.915610064271708e-09 / 5.737302226316655e-07 / 1.2839131009976642e-05 0.001673 3 270 AGTPBP1_2 0.0000000112 0.00010643560926875712 / 0.0014494282385407017 / 0.003851986494620127 3.4005559000932834e-05 / 5.086114917232466e-05 / 2.3120980016650736e-05 0.001803 3 271 TAGLN2_5 0.0000000000 0.0023516155321212286 / 0.0005452799037971314 / 0.002719578191920108 5.193860370029491e-08 / 1.8066076033567137e-05 / 2.887575861701981e-05 0.001872 3 272 CCNT1_4 0.0000000000 0.00022838881607180578 / 2.554651598059182e-05 / 0.006324061390967165 5.780726368884951e-06 / 4.298018160630921e-06 / 8.210854046814278e-06 0.002193 3 273 KCNN4_1 0.0000000002 0.004613449756294485 / 0.0019027179320774803 / 0.0003168019030192227 1.128508207742848e-07 / 3.8845776675460915e-08 / 1.2490905944573221e-07 0.002278 3 274 PEA15_1 0.0000000021 0.004613449756294485 / 0.0003168019030192227 / 0.0019027179320774803 3.828734914704096e-08 / 3.8329007469588033e-07 / 4.539908056270449e-05 0.002278 3 275 SAMD9_1 0.0000020075 0.004613449756294485 / 0.0019027179320774803 / 0.0003168019030192227 1.631780084189698e-08 / 1.293907975082848e-05 / 2.4553942312433883e-05 0.002278 3 276 TRADD_3 0.0000000103 0.0009229889305125405 / 0.005966882987573243 / 0.00022527887387849618 1.9518812703705133e-06 / 0.0006939505597308152 / 1.9336719955298165e-06 0.002372 3 277 TAF5_3 0.0000000136 0.0003947059228531657 / 0.00045641021220350523 / 0.006335832620557736 1.7233340819541832e-07 / 2.5952887221237527e-06 / 8.18333648588888e-05 0.002396 3 278 EFHD2_4 0.0000000000 0.00723849757956334 / 1.3696651981584819e-05 / 6.311409747603608e-05 2.4861210722153842e-05 / 2.247788787753732e-05 / 1.516759330888414e-06 0.002438 3 279 YIPF2_1 0.0000006993 0.0008973831238703076 / 0.0005658979552839525 / 0.0060047412034100744 9.922731214680193e-08 / 7.852806908257148e-06 / 0.0001985413552316056 0.002489 3 280 ZBED4_2 0.0000001314 0.0007128826028020409 / 0.0020168985989813806 / 0.00482573534583834 9.098868701321864e-08 / 1.2243260078905274e-05 / 0.0008067113425139145 0.002519 3 281 RAB3C_1 0.0000014208 0.0012733956455115425 / 0.004613449756294485 / 0.0019027179320774803 5.90994322935669e-07 / 1.1108797731264583e-05 / 4.4376112397274685e-05 0.002597 3 282 FOSL1_4 0.0000000000 0.007490059087712426 / 0.00021444125068471832 / 0.00012920787797071663 5.556372147557157e-06 / 7.999218077760667e-07 / 2.9367679374215882e-05 0.002611 3 283 INA_2 0.0000002325 0.000506059688566897 / 0.006967423038249733 / 0.000365164824725025 2.655622703010865e-07 / 6.037515871423344e-07 / 0.001167614468808287 0.002613 3 284 FLVCR1_2 0.0000000042 5.3340489000579145e-05 / 0.0015899100236963135 / 0.006521228618588356 1.302715543173824e-07 / 3.714456265544689e-05 / 1.704949565638429e-05 0.002721 3 285 ATF7IP2_5 0.0000000000 0.0032839512279112418 / 0.002993599664223763 / 0.002476029139206104 8.537589066325822e-06 / 2.5436790588774414e-05 / 5.142377607346069e-07 0.002918 3 286 S100A10_1 0.0000008705 0.0030838618137353662 / 0.0016555906467057811 / 0.004531342266561176 1.1613890918983097e-06 / 1.6946838169885616e-05 / 9.665990417390237e-05 0.00309 3 287 TRIP6_1 0.0000002147 6.392429369799613e-05 / 0.008158453075892491 / 0.0012146763275784356 3.2750776669883485e-08 / 4.272773668654882e-07 / 5.404314030094148e-07 0.003146 3 288 EIF3J_2 0.0000000002 0.005021029517387429 / 0.004594623942981826 / 0.0005725315156474846 1.0666101484276558e-06 / 8.707499404147844e-06 / 7.206761532626187e-07 0.003396 3 289 CASP4_1 0.0000000780 0.008158453075892491 / 0.0012146763275784356 / 0.0011036487237694873 2.347967797408527e-08 / 1.0559189019803553e-06 / 3.278522050115709e-06 0.003492 3 290 NSL1_2 0.0000000033 5.3340489000579145e-05 / 0.011092727550841517 / 5.792866128396694e-05 2.2018205271807595e-07 / 0.00024742638651566884 / 3.7695931576460654e-06 0.003735 3 291 VASP_1 0.0000006404 0.009220967328515883 / 0.00029139375190295606 / 0.002271551295087959 1.683199820716066e-07 / 2.799847052848426e-07 / 5.915001438135837e-07 0.003928 3 292 COG2_3 0.0000000010 0.012184597869329615 / 0.00017818061059800717 / 3.3817330366409276e-05 9.88977547194958e-07 / 9.135799923405938e-08 / 3.6569660447432056e-05 0.004132 3 293 STMN4_3 0.0000000000 2.061341498862413e-06 / 0.013557269953071502 / 0.00016739297171412964 1.1827971870760236e-07 / 1.7028450668349932e-05 / 2.2310679101285705e-05 0.004576 3 294 ARID2_1 0.0000005167 0.009220967328515883 / 0.00029139375190295606 / 0.004557941079021841 2.2639222896451386e-07 / 1.109801352982852e-06 / 2.1017914639263102e-07 0.00469 3 295 TMEM145_2 0.0000000541 0.011857375508327873 / 0.0019384937218085618 / 0.0003086352962437011 3.703004816743222e-08 / 9.472094543228691e-06 / 3.7868771404399016e-07 0.004702 3 296 RPS28_2 0.0000000062 0.0013196713645063731 / 0.00015680243457987764 / 0.013122781516773055 2.4859140381808595e-07 / 8.661018242204261e-07 / 1.0278447900767023e-05 0.004866 3 297 BHLHB9_5 0.0000000000 0.000833093052382085 / 0.0017373454847881562 / 0.012094762315019585 0.0003876834856951191 / 0.00025814098757798783 / 0.0012619942783536312 0.004888 3 298 CCT3_2 0.0000003320 0.0053229089046933666 / 0.0035672102749117456 / 0.006424879308109518 1.385234000351963e-09 / 1.1973928792856672e-07 / 8.271151178245213e-07 0.005105 3 299 ZBTB39_1 0.0000012961 0.0002459835698877307 / 0.012131971219889692 / 0.003904810749383955 1.947682987909157e-09 / 4.769808257064375e-06 / 1.009907236026598e-05 0.005428 3 300 TGFBI_1 0.0000001859 0.014968932619439228 / 0.00029139375190295606 / 0.002271551295087959 8.323645474851572e-06 / 2.8646241152477385e-06 / 2.2007597669701546e-05 0.005844 3 301 DRAM1_2 0.0000000007 3.95395916749111e-05 / 0.005028962391482225 / 0.012655371032190181 7.334418459565927e-07 / 2.9757670605999017e-06 / 7.803574545937928e-05 0.005908 3 302 TTC9B_4 0.0000000010 3.2451983838054593e-06 / 0.0027782153739561613 / 0.015336438182107533 5.579389394627073e-06 / 2.6478455347372e-05 / 6.774767693632554e-05 0.006039 3 303 CRABP1_2 0.0000000000 0.00018053504491942103 / 0.0006013127917976173 / 0.017420025549877295 3.6420294337565723e-08 / 4.7891636027032046e-05 / 2.4547340474687967e-05 0.006067 3 304 PRNP_1 0.0000012041 0.008158453075892491 / 0.01165101001080378 / 0.0011036487237694873 1.1937594193840056e-07 / 3.852111240660634e-06 / 7.982699562459387e-07 0.006971 3 305 RNF216_2 0.0000000710 0.01978912870326623 / 0.0009038593586046481 / 0.001339659580920153 1.2928230810660568e-06 / 1.509161544583804e-07 / 3.464852330723318e-06 0.007344 3 306 KCNH2_1 0.0000005910 0.0011929519758551942 / 0.013144247549246738 / 0.007698641086675404 4.050881868723152e-06 / 5.993445368097023e-06 / 9.184683537215863e-05 0.007345 3 307 HDAC2_1 0.0000111884 0.0013546126949011356 / 0.015529327313804105 / 0.0060782790336966815 8.678070199327975e-10 / 9.165188556262711e-07 / 1.9640719268488575e-07 0.007654 3 308 LDLRAD3_2 0.0000000086 0.000790463498248653 / 0.022196441234578132 / 2.1369034750623554e-06 2.3758722136689975e-06 / 9.69193707515232e-05 / 3.165236790324336e-05 0.007663 3 309 DLG2_1 0.0000004953 9.390951294242489e-05 / 4.611763366846969e-05 / 0.023379270483941148 1.6435897498809227e-05 / 8.947838561493191e-07 / 0.0005491970493346228 0.00784 3 310 ABHD2_2 0.0000007167 0.007702284030015268 / 0.015157007205383797 / 0.002098496534836373 6.150334665817541e-07 / 2.79918960850902e-06 / 1.3380586388949062e-06 0.008319 3 311 FICD_1 0.0000000879 0.00042879723237597764 / 0.003993715376548959 / 0.02118368053863915 2.9785947869700167e-06 / 6.873856442248643e-07 / 6.404598440436032e-07 0.008535 3 312 EML5_1 0.0000186293 0.0003816779304374477 / 0.007313973432554173 / 0.019582037452342965 1.768922156010669e-08 / 3.733774907814613e-07 / 8.463320131580384e-05 0.009093 3 313 ZNF280B_1 0.0000176080 0.0002021790532799894 / 0.012782548244800053 / 0.015382714940475899 4.16735367252946e-06 / 1.8932170047411166e-06 / 0.0006150439183333181 0.009456 3 314 MAST1_1 0.0000012460 0.0030838618137353662 / 0.0016555906467057811 / 0.02419315699804896 1.008321219643804e-08 / 6.59179220363995e-08 / 2.8729044379438386e-06 0.009644 3 315 NBR2_4 0.0000000013 0.0030139413806392025 / 0.02262700624929458 / 0.004062778899218961 2.6809213542125635e-07 / 3.3592733116787e-06 / 5.084507985309251e-05 0.009901 3 316 ZSCAN16_1 0.0000021993 0.009406629582018086 / 0.007054606953047138 / 0.013414705614259708 3.1919700086632823e-08 / 4.241176857088593e-06 / 1.10182899392691e-05 0.009959 3 317 CD109_1 0.0000004857 0.0030838618137353662 / 0.026132194840960694 / 0.0016555906467057811 4.1459663612593765e-07 / 1.133270373704853e-05 / 6.95591696890365e-07 0.010291 3 318 ASCL1_1 0.0000012961 8.712601577854501e-09 / 0.0014562282237067896 / 0.029987683740818265 6.622928776298776e-08 / 4.986303622240574e-07 / 5.121638955023879e-05 0.010481 3 319 PRCC_2 0.0000000009 0.02916029058932568 / 1.4053286193768942e-05 / 0.0033436620457161664 4.234540029087047e-09 / 7.396677617376084e-08 / 5.762915371340719e-06 0.010839 3 320 SYPL1_3 0.0000000001 0.0010868506221494473 / 0.03062224194622656 / 0.0008798790932645847 1.8036241827089262e-07 / 1.170707624311846e-06 / 8.621104111789159e-06 0.010863 3 321 CACNA1B_3 0.0000023253 0.0006313127973618962 / 0.026533133928238382 / 0.00548175365183452 4.657105147722875e-06 / 0.00011767035322254456 / 0.0009513496148143766 0.010882 3 322 FEV_3 0.0000000016 0.0018157417923330308 / 0.0005005652894286239 / 0.03138718307129687 5.9293955966041735e-08 / 1.9491788120934706e-06 / 3.089744526549523e-05 0.011234 3 323 VSTM2A_2 0.0000000860 0.000506059688566897 / 0.02830343719752466 / 0.005186853257558283 4.451709831952587e-07 / 0.0006571117480683702 / 0.0019723456239841616 0.011332 3 324 DOC2A_1 0.0000176432 0.00025234279143195943 / 0.005397134900618702 / 0.028677370706029427 2.097886384356248e-06 / 4.3459478389049724e-07 / 7.808876942721705e-07 0.011442 3 325 MTR_1 0.0000001011 9.388757698010748e-05 / 0.015063580358728427 / 0.020113164514031456 2.0462926382898192e-05 / 2.0838053089232e-06 / 0.0006005512194214275 0.011757 3 326 TMEM184B_1 0.0000052583 0.017443397981769932 / 0.002318126437551203 / 0.017145541610166553 5.074118788922354e-08 / 1.528139375785279e-07 / 1.361457730245486e-06 0.012302 3 327 ARID2_3 0.0000002768 0.005599828148522198 / 0.014996743361982036 / 0.018170592466726792 9.116542240665922e-09 / 1.5456378377669386e-06 / 4.750875211998681e-06 0.012922 3 328 TSEN54_2 0.0000000000 0.00021036438824558563 / 0.0016249672415913465 / 0.03836197892479358 1.419950215795548e-07 / 1.6203351133132878e-07 / 1.5720016310468745e-05 0.013399 3 329 LAMP2_1 0.0000061826 0.0006291978832262494 / 0.017133475216302412 / 0.02253012830344572 2.3046914608799517e-06 / 5.662655646886999e-07 / 4.09648566039462e-06 0.013431 3 330 GPX8_1 0.0000006021 0.007054606953047138 / 0.009406629582018086 / 0.024046868563271137 7.3135246584530174e-09 / 6.656311691714102e-10 / 6.25392798502714e-06 0.013503 3 331 PRIM1_1 0.0000003223 0.0019943829025712437 / 0.032332967518234994 / 0.006230194892575304 7.867184240616801e-06 / 5.037758463198267e-08 / 2.7703126525457583e-06 0.013519 3 332 MMD_3 0.0000000000 0.00026462416519984375 / 0.04009931021218081 / 0.0018585225095028022 3.265086074696618e-08 / 3.8983782729439324e-05 / 5.764266261871919e-06 0.014074 3 333 HSPD1_1 0.0000016837 0.029245906890336886 / 0.012044249045532097 / 0.0010265738076671066 3.4847461970373735e-08 / 5.585527560266155e-06 / 7.023185063013887e-06 0.014106 3 334 TNFRSF12A_5 0.0000000000 0.032768876151590194 / 0.009211796235391962 / 0.0006064986533695733 9.11501895060049e-06 / 1.6191708335697414e-05 / 3.563543914807607e-06 0.014196 3 335 PLP2_4 0.0000000002 0.043329534197300235 / 4.1971169891966186e-05 / 0.00011139453192955434 4.795701871201485e-07 / 3.953822199723069e-06 / 0.002463554449974249 0.014494 3 336 SNX3_1 0.0000004514 0.012469105184180684 / 0.009827915816152012 / 0.02176087444903759 1.575326562154422e-07 / 1.0953632726584286e-07 / 4.669480873853378e-06 0.014686 3 337 SMC3_1 0.0000067784 0.01903033340546255 / 0.025082579510674555 / 0.0002021790532799894 7.004137458574501e-07 / 7.700331048016097e-07 / 1.9353158268148655e-06 0.014772 3 338 ARHGAP1_1 0.0000026967 0.017145541610166553 / 0.011413935706631708 / 0.017443397981769932 1.3146010474489681e-05 / 4.804751045086965e-06 / 2.132159178159428e-06 0.015334 3 339 LPP_1 0.0000033409 0.01487722458866696 / 0.0017052769733922298 / 0.02985182122259529 1.546223090931648e-07 / 4.2508307877523196e-08 / 1.4414883845347043e-06 0.015478 3 340 MGAT1_1 0.0000004092 0.014660785392642973 / 0.017145541610166553 / 0.017443397981769932 1.7966684116150096e-06 / 5.116593940505276e-06 / 1.3410770868177782e-06 0.016417 3 341 TNFRSF1A_3 0.0000000002 0.0028067534068265437 / 0.00042105945887903654 / 0.048060814464615735 1.0121421064420374e-05 / 7.452615942617135e-06 / 9.353097000119014e-05 0.017096 3 342 C12orf10_1 0.0000001344 0.01695446499444467 / 0.014675290351873422 / 0.02095078822868191 9.883275335709048e-07 / 3.3979035604139886e-07 / 1.4183511170080205e-05 0.017527 3 343 KLF15_1 0.0000009834 0.02839442496647524 / 0.011495528751480646 / 0.017748059549662194 2.539351518692909e-07 / 3.996180547635244e-06 / 3.72884546184977e-07 0.019213 3 344 RSL1D1_1 0.0000024224 0.029245906890336886 / 0.029072859932669184 / 0.001209619547547507 1.928466390137773e-09 / 1.7774626241888566e-05 / 2.7621925072470266e-06 0.019843 3 345 CDK2AP2_1 0.0000069090 0.03413875749258289 / 0.008813705248904322 / 0.017145541610166553 7.980991943354118e-06 / 9.182341905056802e-07 / 6.046703803974713e-06 0.020033 3 346 ENOX1_1 0.0000096565 0.017443397981769932 / 0.03683753470884825 / 0.008813705248904322 8.46495419886903e-08 / 2.477238173018046e-06 / 5.706880115624909e-06 0.021032 3 347 KLHL36_1 0.0000009988 0.017443397981769932 / 0.03683753470884825 / 0.008813705248904322 8.55516827501211e-06 / 5.0553384219596765e-06 / 3.3892208678789174e-05 0.021032 3 348 C1R_1 0.0000103261 0.017443397981769932 / 0.011413935706631708 / 0.03683753470884825 5.223576944443697e-10 / 1.278142542397936e-07 / 9.066430827258057e-08 0.021898 3 349 DLL3_1 0.0000022545 0.017443397981769932 / 0.011413935706631708 / 0.03683753470884825 2.879808838966571e-07 / 6.993476243540988e-06 / 7.726331259366366e-07 0.021898 3 350 NPC1_1 0.0000013000 0.023996288711547777 / 0.014582218475483697 / 0.027344357279935363 5.764157631131607e-07 / 2.4200174195178475e-06 / 8.775983171046948e-07 0.021974 3 351 BPTF_1 0.0000012059 0.0010265738076671066 / 0.029245906890336886 / 0.039756863847419444 2.75081594060756e-06 / 1.849240931697844e-06 / 9.833875885810182e-05 0.023343 3 352 CCNB1IP1_1 0.0000010768 0.029245906890336886 / 0.0010265738076671066 / 0.039756863847419444 5.5727604077632575e-08 / 1.0079899592111368e-06 / 6.245632688934216e-06 0.023343 3 353 NPC2_1 0.0000110270 0.03683753470884825 / 0.017443397981769932 / 0.017145541610166553 2.895916979465306e-07 / 4.350257929933473e-06 / 5.881485803416461e-06 0.023809 3 354 ABAT_3 0.0000000001 0.034052040127872246 / 0.006551644901500213 / 0.03343958590730531 4.991017761660758e-05 / 1.6284836400790797e-06 / 5.991633249924668e-06 0.024681 3 355 CEP170_3 0.0000000001 2.3886446874268867e-06 / 3.5555136352418323e-06 8.64144400156011e-07 / 9.9452244969615e-06 2.97E-06 2 356 NUCB1_3 0.0000000000 9.120027832512087e-06 / 4.9060208885387406e-06 4.76082633817649e-08 / 1.542543895417389e-06 7.01E-06 2 357 LAMP1_5 0.0000000000 7.561570077756679e-06 / 7.75081771574093e-06 1.0518690072819026e-09 / 7.017816798332179e-06 7.66E-06 2 358 MAP4_2 0.0000000001 2.1541055929197527e-08 / 1.9308695609987287e-05 3.93734689573353e-09 / 7.038983428807821e-07 9.67E-06 2 359 MSH6_1 0.0000000525 2.098169823270148e-06 / 1.7711409436331332e-05 2.9237170575647894e-07 / 3.223701677601978e-06 9.9E-06 2 360 NECAP2_5 0.0000000000 1.1734627356832365e-05 / 1.4727302282280241e-05 6.34621052304883e-05 / 9.263010355358496e-05 1.32E-05 2 361 RFX7_1 0.0000006461 1.8023978844296698e-06 / 3.772462305351297e-05 1.3777889602205754e-05 / 5.134420163197374e-06 1.98E-05 2 362 LOXL1_1 0.0000000613 8.712601577854501e-09 / 4.778480179883678e-05 3.7451852636473064e-09 / 3.520223337931936e-07 2.39E-05 2 363 RAB11FIP5_1 0.0000003435 8.712601577854501e-09 / 4.778480179883678e-05 8.30614778438761e-09 / 1.875106499909923e-05 2.39E-05 2 364 SYNC_1 0.0000000544 8.712601577854501e-09 / 4.778480179883678e-05 1.8300368947275955e-09 / 1.1156949187536687e-06 2.39E-05 2 365 MYT1_2 0.0000000000 4.852661376064752e-06 / 5.1682368391364916e-05 6.5288974923630765e-06 / 2.33136261456977e-05 2.83E-05 2 366 CNTNAP2_4 0.0000000000 1.9536120969160626e-05 / 4.855499097832519e-05 2.69621468363523e-05 / 0.0005954550144190784 3.4E-05 2 367 SMARCA5_4 0.0000000000 3.104247296762117e-05 / 4.761108954152855e-05 1.84536023077791e-05 / 3.4952774168035884e-05 3.93E-05 2 368 B3GNT9_4 0.0000000000 4.759424034644978e-06 / 0.00012294606259085342 1.6260769696128954e-06 / 0.00010634285087971367 6.39E-05 2 369 GAL_2 0.0000000005 1.1566938688714122e-08 / 0.0001375276427082929 1.8119993137342534e-06 / 0.0013149790281325572 6.88E-05 2 370 TRIM56_5 0.0000000000 0.00014260412953936538 / 2.3479938806380944e-08 3.859067457796533e-06 / 3.656262715818669e-07 7.13E-05 2 371 CRIM1_3 0.0000000004 4.8106808740888186e-05 / 0.00010014977875691996 9.846475238177379e-06 / 5.579017068717648e-08 7.41E-05 2 372 PNMA3_5 0.0000000000 1.701692255505357e-06 / 0.00014830625115725305 2.0336906370795427e-06 / 9.840133053947521e-06 7.5E-05 2 373 HIST3H2A_3 0.0000000000 7.513947614807362e-05 / 0.00011429921060857062 1.068586509856438e-06 / 3.0653385085725396e-07 9.47E-05 2 374 ATCAY_5 0.0000000000 5.4278236645845715e-06 / 0.00020534480614177087 7.732934718383503e-06 / 2.75413488861665e-05 0.000105 2 375 SMARCA4_2 0.0000000016 2.321730111153503e-06 / 0.00022187513044902743 2.120449751487153e-08 / 3.5992692804583596e-05 0.000112 2 376 LIN28B_2 0.0000000000 1.216331498209144e-06 / 0.00029774828278028234 1.1201154484621356e-09 / 7.926073637103903e-06 0.000149 2 377 OLFML2A_5 0.0000000000 8.951974512115386e-05 / 0.00034027362168927155 9.130549898240117e-07 / 2.4504382448983827e-06 0.000215 2 378 ACP1_5 0.0000000000 6.364279791640112e-06 / 0.0004408162010949017 1.6688642528792083e-06 / 1.8017876923145952e-05 0.000224 2 379 ACTL6B_3 0.0000000040 0.0003057625951752015 / 0.00015450477319284894 1.060226377821344e-06 / 2.1353909002247907e-05 0.00023 2 380 PHF21B_4 0.0000000000 7.623480320281502e-07 / 0.0004987725781895633 5.2768179043587e-06 / 1.09188294232324e-06 0.00025 2 381 BAZ1A_1 0.0000069836 0.00064922210107833 / 1.8023978844296698e-06 1.6595910049899672e-07 / 4.925632831272468e-06 0.000326 2 382 TMEM30A_1 0.0000022161 0.0006240411433431414 / 5.2470753247363745e-05 3.5429731576541734e-08 / 5.5462823621098335e-08 0.000338 2 383 NOL11_2 0.0000000000 0.00046464339325169037 / 0.0002564595505663515 5.933716019020396e-07 / 7.456072877479674e-09 0.000361 2 384 BEND4_5 0.0000000000 1.5777685999047575e-06 / 0.0007208108997517884 5.3901186417921756e-11 / 2.815995740727121e-07 0.000361 2 385 ELOVL1_3 0.0000000020 0.0006923847970197059 / 3.196763725059841e-05 2.677497381339075e-07 / 0.00021491113805745135 0.000362 2 386 PFKM_4 0.0000000000 0.0007309049115603717 / 8.501642925216299e-06 9.403882200312194e-08 / 7.819007418155511e-07 0.00037 2 387 NMNAT1_2 0.0000000129 0.0004526675305989492 / 0.0003016808649104736 9.397755887797147e-06 / 0.00010313370779319529 0.000377 2 388 TIGD1_2 0.0000000029 0.00015234942199771114 / 0.000651352109304205 8.064616695114456e-07 / 4.491126688099632e-05 0.000402 2 389 ARL1_5 0.0000000000 1.694043434756899e-05 / 0.0008334490663588983 2.2314679547176197e-07 / 4.126172052886268e-06 0.000425 2 390 CPLX1_4 0.0000000002 0.0008665554418518524 / 5.737321179382452e-06 5.87667964571385e-06 / 3.438314234654185e-05 0.000436 2 391 PAX6_5 0.0000000000 0.00027854752254638905 / 0.0006006286848231235 1.3031733956534446e-07 / 2.2950534119176534e-06 0.00044 2 392 ANXA2_5 0.0000000000 0.00022245643971115814 / 0.0008228851369949542 0.0002774948155360362 / 4.3531858337072534e-05 0.000523 2 393 BHLHE41_1 0.0000003123 3.679473658399758e-05 / 0.0010281262291342236 5.186786515718226e-05 / 4.276807002378442e-05 0.000532 2 394 DPYSL5_2 0.0000000245 0.0005017064663366604 / 0.0006658727095010238 1.0246351818305243e-08 / 2.9985183250414335e-08 0.000584 2 395 NCL_5 0.0000000000 0.0001902762125730563 / 0.0010196091469089486 1.1394612086185451e-07 / 5.477181895031346e-05 0.000605 2 396 NEK6_3 0.0000000000 0.00042892841962168427 / 0.0007955623084328148 4.625637105430227e-06 / 1.9802846632838944e-05 0.000612 2 397 ADAM11_1 0.0000014021 0.00020676489909411184 / 0.0010623957357494855 6.162977005662482e-06 / 1.5065356540452738e-05 0.000635 2 398 BMP1_1 0.0000001479 8.712601577854501e-09 / 0.0014562282237067896 1.0629725087716493e-09 / 3.3335712676585927e-10 0.000728 2 399 CRABP1_1 0.0000012003 8.712601577854501e-09 / 0.0014562282237067896 1.0032588981222376e-06 / 1.6633089557898398e-05 0.000728 2 400 CREB3_1 0.0000002396 8.712601577854501e-09 / 0.0014562282237067896 3.248193062600497e-07 / 1.8160839243636814e-05 0.000728 2 401 CTSB_1 0.0000004048 0.0014562282237067896 / 8.712601577854501e-09 2.7850840733739764e-08 / 6.154886102926167e-07 0.000728 2 402 GLB1_1 0.0000009020 0.0014562282237067896 / 8.712601577854501e-09 5.1549922184344e-09 / 2.2049835157073303e-11 0.000728 2 403 LGALS3_1 0.0000001910 0.0014562282237067896 / 8.712601577854501e-09 3.755610443792837e-07 / 1.150827659828279e-08 0.000728 2 404 SMPD1_1 0.0000000902 8.712601577854501e-09 / 0.0014562282237067896 1.2661160783158677e-07 / 1.5916398320881086e-06 0.000728 2 405 GTPBP4_1 0.0000001295 0.00028286232014178015 / 0.001443320215490813 1.1507531465572511e-05 / 8.380217354744253e-07 0.000863 2 406 ACTR3B_2 0.0000000074 0.00014435842640211195 / 0.0016167318511468814 3.4516372751432266e-05 / 1.6235896245152234e-05 0.000881 2 407 CSRP1_3 0.0000000000 0.0008963909784287442 / 0.0008703935843289303 1.2552190959143249e-05 / 1.0273857961970511e-05 0.000883 2 408 SEPHS1_1 0.0000001827 0.00173044075017522 / 3.679473658399758e-05 8.824502672922857e-06 / 3.0791704702592284e-05 0.000884 2 409 ACTN2_1 0.0000008238 0.0011231690936696782 / 0.0006456808009902826 1.5971362873791044e-06 / 1.6414697658368195e-07 0.000884 2 410 NMRK1_2 0.0000000009 7.927156138657951e-05 / 0.0016947048583457857 1.3825176406826697e-06 / 3.53470906662037e-07 0.000887 2 411 TFAP2A_1 0.0000010622 0.000397182645222389 / 0.001498796467852237 1.6591165825267682e-05 / 3.1676679082128444e-06 0.000948 2 412 CAV1_3 0.0000000000 0.0017923927195771076 / 0.0001624925597934157 1.6411382731391108e-05 / 7.945990872997567e-06 0.000977 2 413 PQLC3_2 0.0000004701 4.389629454841824e-05 / 0.001937287334836558 1.0375195933235037e-08 / 2.8078868409381863e-06 0.000991 2 414 RPL9_4 0.0000000000 3.781374276352481e-05 / 0.002265806028844651 2.8562585574590404e-07 / 1.520546898812959e-06 0.001152 2 415 H2AFY2_3 0.0000000000 0.0023614039163946366 / 5.479642713695821e-06 9.720407948559726e-06 / 2.5274722144655105e-05 0.001183 2 416 MCM10_1 0.0000038124 0.0021610939865988614 / 0.0004600723635955347 1.9111116053257913e-05 / 1.8478236194529347e-06 0.001311 2 417 G6PD_1 0.0000098647 0.0023157697041580965 / 0.0006256240573576323 2.857433835593977e-06 / 2.3724383307219822e-05 0.001471 2 418 TADA1_1 0.0000012097 0.0026490796375761676 / 0.0004052971561229435 3.531944691795736e-06 / 1.881582874926359e-06 0.001527 2 419 KCNC1_5 0.0000000000 1.8731875907040327e-05 / 0.0031223581236072607 7.480602345183493e-06 / 9.900952757251972e-06 0.001571 2 420 JPH4_1 0.0000020704 0.00037839447623271325 / 0.0028279669089626516 1.0663281519153872e-06 / 5.068294298254466e-05 0.001603 2 421 ZNF121_3 0.0000000002 2.4284932942339803e-06 / 0.0032468305940381815 1.097169523033381e-06 / 1.0244293507613468e-05 0.001625 2 422 TMEM206_1 0.0000001917 0.002859168680149655 / 0.0007069744136606002 4.159808093795964e-07 / 7.162200636393188e-06 0.001783 2 423 HS3ST4_1 0.0000030972 0.0027568341257606386 / 0.0008433274564043463 5.152072021912856e-05 / 0.00013189356327001007 0.0018 2 424 MRPL48_1 0.0000003952 0.0037409240031547972 / 1.2412020538304333e-05 0.00010762773346764832 / 5.800656513229227e-07 0.001877 2 425 PPAT_5 0.0000000000 0.0005240883442637788 / 0.0033630327163844836 1.3405009998715396e-07 / 2.0737516222338193e-07 0.001944 2 426 CELF3_3 0.0000000012 2.6606264463249574e-05 / 0.004048158047358375 1.681108063763094e-07 / 6.662779385674438e-06 0.002037 2 427 ABCC8_1 0.0000123268 0.0005728902408745853 / 0.0037587720790259365 2.6233964453337422e-05 / 0.007471621864095462 0.002166 2 428 KIF1C_4 0.0000000003 0.0032619641963901502 / 0.0011569950059438523 8.154868752547337e-07 / 2.557520533005861e-06 0.002209 2 429 MOSPD2_1 0.0000012002 7.763485144629643e-05 / 0.004557941079021841 7.941462431738191e-07 / 1.6722356038590327e-05 0.002318 2 430 ANKRD46_1 0.0000009529 0.0016555906467057811 / 0.0030838618137353662 3.117928478396429e-07 / 1.2106488464901888e-06 0.00237 2 431 RSL24D1_1 0.0000003735 0.0020456136275657888 / 0.002859168680149655 5.740933296039192e-08 / 6.94594888585274e-07 0.002452 2 432 HNRNPC_1 0.0000000442 0.0003168019030192227 / 0.004613449756294485 1.5683726426363387e-05 / 3.1384990249702817e-06 0.002465 2 433 LYST_1 0.0000015802 0.004613449756294485 / 0.0003168019030192227 1.6458786012670833e-07 / 2.821962785745458e-08 0.002465 2 434 MRPS31_2 0.0000000065 0.004772335371973973 / 0.0003355045145354899 3.3355235309279226e-06 / 9.633635724889396e-07 0.002554 2 435 ANXA11_1 0.0000056530 0.005164155170869671 / 0.0004491267996311823 2.916507287390681e-05 / 2.0269807072431288e-06 0.002807 2 436 GABRB3_2 0.0000003351 0.000506059688566897 / 0.005186853257558283 3.096339568332632e-07 / 8.425728705562362e-05 0.002846 2 437 ITGB5_4 0.0000000000 9.326256093187905e-05 / 0.005791631747081949 4.1150806272283625e-06 / 3.579067579944918e-06 0.002942 2 438 TAGLN_5 0.0000000000 0.0016087657150710478 / 0.004695933649935298 1.0747776301357894e-06 / 5.068277336951496e-07 0.003152 2 439 KLF6_1 0.0000063009 0.000825624209859881 / 0.005675752403043091 1.566826366040112e-06 / 2.0575603093756347e-05 0.003251 2 440 GLIS3_1 0.0000001584 0.0019027179320774803 / 0.004613449756294485 8.91146182579548e-08 / 1.1981910549231142e-05 0.003258 2 441 GRPEL2_3 0.0000000000 0.00010726957614676581 / 0.006720367764597034 4.439257342558768e-06 / 8.438825442463246e-05 0.003414 2 442 SORCS1_2 0.0000000000 8.208006168567451e-05 / 0.007038129780933908 7.728334683674074e-07 / 5.209097425595317e-05 0.00356 2 443 TAF3_1 0.0000099483 0.0013546126949011356 / 0.0060782790336966815 1.1902144022027374e-07 / 3.590125727174815e-07 0.003716 2 444 ZNF638_4 0.0000000002 0.004643194113383492 / 0.002879683794588439 1.1731748076272809e-07 / 2.1004419064549084e-06 0.003761 2 445 RPAIN_2 0.0000000089 0.005656902703414097 / 0.0020182027192515075 3.683542119198933e-06 / 5.1931234206185375e-06 0.003838 2 446 PRMT6_2 0.0000000762 4.9232228985570196e-05 / 0.007808321395428832 8.633725399474921e-08 / 1.0594310607660115e-06 0.003929 2 447 CERCAM_1 0.0000000458 0.007033451966587178 / 0.0011697552308872906 2.6140734636276835e-07 / 3.3435498079309047e-05 0.004102 2 448 TWSG1_1 0.0000001761 6.392429369799613e-05 / 0.008158453075892491 5.157744855455523e-08 / 1.1607198631441237e-05 0.004111 2 449 NAP1L1_1 0.0000006251 0.0009903851658940631 / 0.00741156873832107 3.573144437875835e-08 / 2.6755598797458433e-05 0.004201 2 450 NQO2_1 0.0000003120 0.008488814061362355 / 9.017693290134859e-06 2.7731541539595674e-05 / 2.8873360375852757e-06 0.004249 2 451 EXOSC5_1 0.0000025109 0.0004974933526793384 / 0.008173144283430401 7.804789577957665e-13 / 7.74266535906266e-08 0.004335 2 452 LTBP2_1 0.0000549802 0.0001478074168080298 / 0.008876460493888159 0.00010798007651110131 / 4.222343931835182e-06 0.004512 2 453 KIAA1549_3 0.0001342161 0.0026287641054243034 / 0.006519007047359032 7.168411667949609e-07 / 5.5430987684595595e-06 0.004574 2 454 LRP10_2 0.0000001825 0.005921869111264299 / 0.003413606680030668 2.207361096450598e-08 / 3.3470759617279554e-06 0.004668 2 455 CIB1_4 0.0000000168 0.009433179531708233 / 3.3215427791608696e-05 4.2846313000380545e-08 / 3.7292417647649567e-07 0.004733 2 456 RPL19_1 0.0000014928 0.009179325672229992 / 0.00029389877591584477 7.496923788892963e-09 / 2.8239822943662147e-07 0.004737 2 457 CBX2_2 0.0000000000 4.7075406338787466e-05 / 0.00976885548005096 4.131142779946589e-09 / 5.375769141126671e-07 0.004908 2 458 CLVS2_2 0.0000001913 0.009406082212144616 / 0.0006563295421036791 2.5714332068383276e-06 / 5.482716962081155e-06 0.005031 2 459 GLIPR1_2 0.0000000000 3.466171778138515e-05 / 0.010368022895379076 5.654483400792844e-07 / 5.55002977254214e-06 0.005201 2 460 TAPBP_3 0.0000000000 8.512267986732582e-07 / 0.011323761387770928 4.890820513972833e-08 / 6.67431019433855e-06 0.005662 2 461 GNA12_3 0.0000000000 0.001517583413099564 / 0.009900066282835398 6.708969086365922e-07 / 9.569962786694717e-06 0.005709 2 462 MBNL1_1 0.0000001024 0.002859168680149655 / 0.008597087236259153 2.975015241938413e-06 / 0.00015116218032026587 0.005728 2 463 ISYNA1_2 0.0000000015 0.005657495944434386 / 0.006635836004693275 6.464027654347149e-08 / 2.887101958288562e-06 0.006147 2 464 PRLHR_2 0.0000005406 0.007129272200886299 / 0.0052714519884625305 7.77168866368208e-06 / 1.8437240853929896e-05 0.0062 2 465 IQGAP1_5 0.0000000000 0.012455997462084369 / 1.7523681094523592e-05 1.1619283901710663e-08 / 3.139400513751516e-09 0.006237 2 466 SDC4_2 0.0000000000 3.95395916749111e-05 / 0.012655371032190181 4.7350612738275925e-07 / 4.772494328825351e-05 0.006347 2 467 NAA25_1 0.0000047407 0.0004974933526793384 / 0.012491622786737646 8.408015879409482e-10 / 1.1193839755975793e-07 0.006495 2 468 PLEKHA4_1 0.0000000554 0.012681018200430948 / 0.0008147104901488364 4.9420107205779745e-08 / 0.00013683562427249123 0.006748 2 469 TUBA4A_2 0.0000001526 0.0004894051617618149 / 0.013748845190012026 7.439143899721087e-06 / 5.6974125969133664e-05 0.007119 2 470 SLC35D1_1 0.0000119741 0.0011586570434241133 / 0.01344459083967992 7.589908369304536e-05 / 2.286469998615828e-06 0.007302 2 471 SH3GLB1_1 0.0000007167 0.005409509534570436 / 0.00920357999307954 2.215338831755982e-08 / 9.144219102907184e-05 0.007307 2 472 RPL37_1 0.0000002993 0.00029139375190295606 / 0.014437131210731376 1.5481316880518014e-06 / 1.2695577765486368e-06 0.007364 2 473 KDELR3_3 0.0000009988 0.005599828148522198 / 0.009406629582018086 3.321175066033386e-08 / 1.7651037681600008e-10 0.007503 2 474 DDX60L_1 0.0000004277 0.014968932619439228 / 0.00029139375190295606 3.349293334251501e-05 / 3.67192886950216e-06 0.00763 2 475 GNPDA2_1 0.0000009111 0.012345925407573809 / 0.0029871868526872383 1.0139345130923212e-06 / 7.401416660830965e-06 0.007667 2 476 DPY30_1 0.0000001493 0.01474377883043126 / 0.0008872221356225374 8.242352750056853e-06 / 1.0099284699945813e-06 0.007816 2 477 MURC_2 0.0000010524 0.002464237492576691 / 0.013298076855589635 0.00016259523386897824 / 1.28646138088586e-05 0.007881 2 478 CCDC80_2 0.0000000780 0.007022396430063894 / 0.009406629582018086 1.9897144922152364e-08 / 5.96038844248789e-08 0.008215 2 479 C12orf23_1 0.0000007686 0.007054606953047138 / 0.009406629582018086 2.070000126404187e-09 / 3.064830496384329e-08 0.008231 2 480 LOX_1 0.0000004721 0.007054606953047138 / 0.009406629582018086 5.585615326605659e-08 / 2.025993050202001e-07 0.008231 2 481 CEP68_3 0.0000000000 0.014160855902587557 / 0.0025428536177246916 6.659688421576734e-07 / 9.407794731883787e-07 0.008352 2 482 BEND3_1 0.0000004060 0.015529327313804105 / 0.0013546126949011356 1.294856510154241e-07 / 7.843354585243828e-07 0.008442 2 483 RPRD2_3 0.0000001192 0.0042160036963409305 / 0.013951484913323634 3.745187782499438e-06 / 6.105707567166931e-05 0.009084 2 484 ELAVL4_3 0.0000000002 0.006262584938725883 / 0.012965192074116545 1.9990927267649097e-08 / 1.2028673633713268e-05 0.009614 2 485 TRIM21_1 0.0000010287 0.010532112594999697 / 0.00986299981987636 5.27087064977811e-07 / 1.4605266535016458e-05 0.010198 2 486 PRPF40B_1 0.0000427258 0.017494900781073297 / 0.0030164053071970965 1.5471503143081632e-06 / 5.832024795399863e-07 0.010256 2 487 DCLRE1A_1 0.0000061634 0.004458350846430188 / 0.0169361079209336 1.1237015427476724e-07 / 3.0864109406370913e-05 0.010697 2 488 DUSP12_1 0.0000017501 0.0005152101842532016 / 0.020927835765182444 1.3639586195049048e-06 / 3.496306255304265e-05 0.010722 2 489 TFPI_2 0.0000000132 4.6545402569552315e-05 / 0.02149290799813975 4.887360747506771e-06 / 4.0474405834306e-05 0.01077 2 490 MYO1C_2 0.0000000121 0.017895823171364 / 0.006230846374778002 3.081448301668384e-05 / 4.014555294520703e-06 0.012063 2 491 SYDE1_1 0.0000000110 0.00772762240557102 / 0.016780696985377475 1.1653781269953101e-07 / 3.463671891124625e-05 0.012254 2 492 RANBP1_1 0.0000003587 0.007033451966587178 / 0.018278644383879286 1.8768112225438676e-06 / 2.385161536231052e-05 0.012656 2 493 PRAME_3 0.0000000000 0.00027122572057250454 / 0.02549151253917823 7.315372425838117e-07 / 0.0043647330554926495 0.012881 2 494 PNN_1 0.0000004953 0.023632426585188764 / 0.0037180700854572363 1.567862197944385e-05 / 1.9432605539900083e-06 0.013675 2 495 PHF11_3 0.0000000000 0.0199742851386832 / 0.0074443763066621635 2.2460867352749832e-05 / 4.034050219148119e-05 0.013709 2 496 WDR35_1 0.0000956275 0.00595365839866055 / 0.022259394060437563 2.301536456666849e-08 / 4.7905231342002456e-05 0.014107 2 497 KCNN4_5 0.0000000000 0.028325850554739726 / 1.0422333032628909e-05 4.2230909676496135e-06 / 6.214193085118779e-08 0.014168 2 498 SERPINB6_1 0.0000000860 0.02111164899698619 / 0.007725328433277938 2.187431797229529e-06 / 2.509158352753995e-06 0.014418 2 499 ACOT9_5 0.0000000000 8.858145837069308e-06 / 0.02928133094687868 1.4274535341490866e-06 / 1.1707897663572821e-05 0.014645 2 500 LAMP1_2 0.0000000008 0.030054976866849478 / 8.732445306306717e-05 5.466481696938671e-06 / 1.5820496858297314e-06 0.015071 2 501 C19orf10_2 0.0000012073 0.007022396430063894 / 0.02370242637699958 1.3938096456595192e-06 / 3.106836436822797e-06 0.015362 2 502 EHD2_1 0.0000051889 0.006387086743044337 / 0.024359073362915318 3.1581541925072244e-08 / 6.252023917064675e-07 0.015373 2 503 DPH5_1 0.0000000253 0.005268014147815726 / 0.025798539904455884 7.65363618891567e-06 / 2.5443259723878794e-07 0.015533 2 504 TMEM169_1 0.0000042184 0.015328857071669418 / 0.01613036709497828 5.271735025959501e-06 / 7.657861944466996e-06 0.01573 2 505 SMARCB1_1 0.0000002644 0.02077959376727299 / 0.011174729900658115 8.011755580473669e-08 / 3.2615951234563365e-06 0.015977 2 506 PLEKHF2_1 0.0000084591 0.030555512760793904 / 0.0019120019643383967 6.139203454059454e-06 / 1.7597453128430795e-05 0.016234 2 507 HSF2_5 0.0000000024 0.0011883468549077506 / 0.032054869676694284 3.40227203271683e-05 / 0.00014757007119292403 0.016622 2 508 ASPH_1 0.0000002995 0.033538144332397844 / 0.00028614552404424633 5.685936788307393e-09 / 9.429685991450496e-08 0.016912 2 509 SERINC3_1 0.0000008790 0.033538144332397844 / 0.00028614552404424633 2.49764511508294e-09 / 1.134358362342082e-07 0.016912 2 510 THOC5_1 0.0000003036 0.013135303284974763 / 0.02077959376727299 2.342665333258182e-05 / 2.6803490912759556e-06 0.016957 2 511 SLC6A15_1 0.0000005833 0.004726766888964287 / 0.029245906890336886 3.0205657665658226e-07 / 1.9753690366539358e-07 0.016986 2 512 TBC1D2_1 0.0000051878 0.0026971498523362084 / 0.03142306493318558 2.36394903321324e-07 / 3.4669139065625866e-06 0.01706 2 513 HSPG2_1 0.0000035348 0.005508211750735854 / 0.029004639226340192 3.456379747077034e-08 / 1.3650260422668218e-06 0.017256 2 514 CACNA2D2_1 0.0000002397 0.012989035651382866 / 0.0220527090420233 9.84795387151116e-07 / 0.00014763731434387815 0.017521 2 515 SLC5A6_2 0.0000000011 6.726351690377188e-06 / 0.03632726905839838 3.564147772687014e-09 / 2.3833706506813445e-08 0.018167 2 516 DAZAP1_2 0.0000010886 0.035346052334371256 / 0.0020041144974840427 6.336641396851863e-06 / 2.7162116297049073e-06 0.018675 2 517 NFIX_2 0.0000470223 0.034278763403653136 / 0.004363119893312578 3.742274946692005e-08 / 8.621152000254767e-06 0.019321 2 518 ELAVL3_3 0.0000002367 0.032717168309564344 / 0.00603260340463039 5.233156358088248e-08 / 1.2259141243737108e-05 0.019375 2 519 COPB2_1 0.0000009988 0.030556265901493518 / 0.009461453275903385 7.7726596868819e-09 / 1.2483359571678263e-07 0.020009 2 520 ZNF219_1 0.0000201928 0.0013753510178836541 / 0.040351165135619635 4.130137554486895e-08 / 8.551025528226429e-06 0.020863 2 521 RNF165_2 0.0000000071 0.00045689445671322015 / 0.04290525645291146 4.007091987107082e-07 / 5.771520423008575e-06 0.021681 2 522 P4HA1_1 0.0000001230 0.03388354547402121 / 0.009805971532350915 0.0006317756731189806 / 1.426894913839978e-05 0.021845 2 523 CIB2_3 0.0000052976 0.03149060869705135 / 0.012259451329060318 9.024424890774902e-07 / 1.0442027429124592e-07 0.021875 2 524 LMAN2_1 0.0000170444 0.01903033340546255 / 0.025082579510674555 7.009613011978967e-07 / 2.5751189172533023e-06 0.022056 2 525 POFUT1_1 0.0000072701 0.001142587490178054 / 0.043241971329782115 7.112620349907573e-07 / 1.1322431164545276e-05 0.022192 2 526 ITGB1_1 0.0000003907 0.02269898054008244 / 0.0248532779265148 7.3505722166603895e-09 / 1.5385068037778083e-08 0.023776 2 527 GFPT2_2 0.0000000000 0.04814570015405706 / 9.938212812133593e-06 1.3739713879197712e-06 / 1.5888765178369776e-06 0.024078 2 528 SNTB2_2 0.0000013898 0.00045763370789409137 / 0.04798455655539519 4.937390910049744e-08 / 1.0481483686547674e-06 0.024221 2 529 FAM126A_1 0.0000076004 0.008114330308262623 / 0.043466125038867966 6.442446565574853e-07 / 7.404414626788326e-07 0.02579 2 530 FAM214B_1 0.0000010912 0.007767111012470563 / 0.04394971982153738 9.766150972459384e-09 / 5.811940190116354e-06 0.025858 2 531 E2F5_1 0.0000013604 0.049711930848541044 / 0.0033175174072552346 4.003267630664399e-07 / 9.866737749751602e-07 0.026515 2 532 CRMP1_1 0.0000084591 0.017443397981769932 / 0.03683753470884825 8.413742944743679e-07 / 4.106621117381678e-06 0.02714 2 533 DTX3L_1 0.0000084583 0.03683753470884825 / 0.017443397981769932 6.797147151581183e-07 / 1.417692420229351e-07 0.02714 2 534 ELAVL3_1 0.0000001607 0.03683753470884825 / 0.017443397981769932 1.3771030020123217e-07 / 1.1898412039254247e-06 0.02714 2 535 GATA2_1 0.0000032251 0.017443397981769932 / 0.03683753470884825 2.379056852862588e-07 / 7.419739232422929e-07 0.02714 2 536 GNG4_1 0.0000011175 0.017443397981769932 / 0.03683753470884825 2.833288980358075e-07 / 3.0194192839021757e-06 0.02714 2 537 GPX8_1 0.0000018792 0.017443397981769932 / 0.03683753470884825 1.1126780547850324e-07 / 3.7460365163269813e-07 0.02714 2 538 LATS2_1 0.0000002146 0.017443397981769932 / 0.03683753470884825 8.009574761254957e-07 / 7.564366651535585e-06 0.02714 2 539 TMEM87B_1 0.0000035381 0.046460374349346606 / 0.00986299981987636 2.2083608853369944e-06 / 2.6000415048116556e-06 0.028162 2 540 NR2C1_1 0.0000011174 0.049070601469191656 / 0.00773983756525658 1.016347019186649e-05 / 2.9570254790683987e-05 0.028405 2 541 CHMP4B_1 0.0000228401 0.023755415081211387 / 0.03496487724871062 7.568402263460558e-06 / 1.602695870510606e-06 0.02936 2 542 HPDL_1 0.0000326628 0.04277794935005184 / 0.01886546643390927 2.946919779060583e-07 / 2.526544471155658e-06 0.030822 2 543 HNRPDL_1 0.0000017461 0.029245906890336886 / 0.03496385796284249 5.094906510060717e-06 / 0.0005450663768553773 0.032105 2 544 MICB_1 0.0000005886 0.03856382315007413 / 0.030649533557856844 3.2225183304348016e-07 / 2.082657792499939e-05 0.034607 2 545 C17orf53_5 0.0056512849 0.03313812387988766 / 0.0369823965122664 1.7766971737416816e-07 / 4.945807676396787e-08 0.03506 2 546 WDR3_1 0.0000063135 0.038526552055961574 / 0.033508173499253606 1.3194741430704085e-06 / 5.999026130299875e-08 0.036017 2 547 FKBP15_1 0.0000015165 0.038665976753680685 / 0.037764618743349666 1.938771779561528e-07 / 8.867393316201706e-07 0.038215 2 548 SLC22A23_1 0.0000002831 8.712601577854501e-09 1.4395456175321122e-06 8.71E-09 One 549 ST6GALNAC3_1 0.0000002679 8.712601577854501e-09 1.7157900523441861e-07 8.71E-09 One 550 RCAN1_3 0.0000000016 3.499510929936492e-08 1.26835830581151e-07 3.5E-08 One 551 CCDC107_2 0.0000000001 6.395893878746714e-08 9.461935060607236e-07 6.4E-08 One 552 PAX6_2 0.0000000009 7.077258149360326e-07 9.972664897230697e-08 7.08E-07 One 553 IGSF9_5 0.0000000004 1.1979104163692412e-06 8.265188982147678e-06 1.2E-06 One 554 TFAP4_2 0.0000000085 2.321730111153503e-06 1.7564281952911052e-07 2.32E-06 One 555 B2M_5 0.0000000000 2.8861862169068284e-06 4.480381749486679e-06 2.89E-06 One 556 ZCCHC12_1 0.0000002526 3.027796588478565e-06 3.463674540195252e-08 3.03E-06 One 557 MYL12B_3 0.0000000860 3.036941140125125e-06 1.4602780290417217e-05 3.04E-06 One 558 SHPRH_5 0.0000000003 5.230619502812216e-06 2.937677082211747e-07 5.23E-06 One 559 NRSN1_4 0.0000000000 5.476196107524447e-06 2.997579133447394e-06 5.48E-06 One 560 HNRNPR_3 0.0000000000 5.558921390245165e-06 3.126649204411196e-06 5.56E-06 One 561 RRAGC_2 0.0000000001 5.618452957713235e-06 9.311046175034272e-06 5.62E-06 One 562 CTSA_3 0.0000000013 6.56608104779876e-06 2.506639438406534e-09 6.57E-06 One 563 DUSP26_3 0.0000000000 7.058822532691102e-06 4.827489564324781e-06 7.06E-06 One 564 IFI35_2 0.0000000001 7.334382821279422e-06 3.030479316814345e-07 7.33E-06 One 565 FAM163A_4 0.0000000000 9.356029087940393e-06 1.1664211635226015e-06 9.36E-06 One 566 DHX15_3 0.0000000002 9.568251410073365e-06 2.403428814770779e-07 9.57E-06 One 567 WDR86_3 0.0000000000 1.0462572531149967e-05 5.73499996685614e-06 1.05E-05 One 568 CECR5_1 0.0000003529 1.2412020538304333e-05 8.265652927676646e-07 1.24E-05 One 569 VASH2_1 0.0000000292 1.2412020538304333e-05 2.7260938912368544e-09 1.24E-05 One 570 KCNH8_2 0.0000000001 1.3893428326375037e-05 1.025651613746495e-06 1.39E-05 One 571 MRPS25_3 0.0000000000 1.4962982992013249e-05 5.883502199500679e-05 1.5E-05 One 572 COPS7B_4 0.0000000000 1.9055379659727616e-05 1.8406897134601384e-06 1.91E-05 One 573 PHYHIPL_2 0.0000000044 1.9765992682251932e-05 7.662073328952884e-08 1.98E-05 One 574 ATP6V0E1_3 0.0000000000 2.1199783161506686e-05 3.178350125115292e-06 2.12E-05 One 575 CEP44_5 0.0000000000 2.6817088180208884e-05 3.075797968981328e-07 2.68E-05 One 576 SEC22C_1 0.0000126263 3.772462305351297e-05 2.5473717020986836e-06 3.77E-05 One 577 TRIM38_2 0.0000000010 4.232307256197528e-05 9.004771302620853e-07 4.23E-05 One 578 MTF2_1 0.0000003729 4.778480179883678e-05 3.677618476819043e-06 4.78E-05 One 579 ZC3H15_4 0.0000000000 4.99139389651813e-05 8.062168588983905e-05 4.99E-05 One 580 THOC5_2 0.0000000078 5.370663550005663e-05 9.265177499664469e-07 5.37E-05 One 581 CLASP2_2 0.0000000009 5.412804644102036e-05 3.7830870595223054e-07 5.41E-05 One 582 SLC18A2_2 0.0000000045 5.6390218253045825e-05 1.7279928388791176e-05 5.64E-05 One 583 NDUFAF4_4 0.0000000000 5.8700155983793994e-05 2.5189349324309824e-08 5.87E-05 One 584 CHD4_1 0.0000002613 6.392429369799613e-05 4.5917357478734616e-10 6.39E-05 One 585 KIF5A_3 0.0000000388 6.823910763393263e-05 2.8021219460869213e-07 6.82E-05 One 586 CNN2_2 0.0000000049 7.667846295453872e-05 4.936771116007079e-06 7.67E-05 One 587 DCBLD1_2 0.0000000000 7.734573702217467e-05 2.622737549604328e-07 7.73E-05 One 588 SPSB4_2 0.0000000009 7.736803917574157e-05 1.665549189503519e-06 7.74E-05 One 589 EDIL3_1 0.0000003533 7.763485144629643e-05 2.106653942117265e-06 7.76E-05 One 590 GALNT10_3 0.0000000000 8.677918268232137e-05 8.482412543283543e-07 8.68E-05 One 591 H1FX_1 0.0000006013 9.000996792266372e-05 3.1636024561990265e-07 9E-05 One 592 OSGIN1_4 0.0000001415 9.283230157343638e-05 1.9657683205901488e-07 9.28E-05 One 593 PRRX1_1 0.0000004579 9.464090281065672e-05 3.3589212783746634e-09 9.46E-05 One 594 SERF2_1 0.0000008582 9.559019073817654e-05 3.4428228168417093e-07 9.56E-05 One 595 PPP1CC_3 0.0000000001 9.749181327114085e-05 1.7389165234639967e-07 9.75E-05 One 596 SYDE1_2 0.0000000598 0.00010643560926875712 1.503089017990499e-07 0.000106 One 597 C11orf74_2 0.0000000007 0.00010744642656817331 1.4631867053999944e-05 0.000107 One 598 NEFH_1 0.0000000473 0.00011095297992729127 1.5371136619548915e-05 0.000111 One 599 MPPE1_2 0.0000000746 0.00011144654065968228 1.6486688003824867e-06 0.000111 One 600 RAC3_1 0.0000011018 0.00012418009082273935 4.416840433956102e-05 0.000124 One 601 XRCC2_1 0.0000063155 0.0001281986995674009 2.3117725678541128e-08 0.000128 One 602 PVRL2_2 0.0000000002 0.00013157696997892983 1.9665782290909765e-07 0.000132 One 603 JAKMIP1_3 0.0000000000 0.0001624284911175795 1.3322851721010925e-05 0.000162 One 604 RETSAT_2 0.0000000021 0.00018285567959994966 2.2405276167100574e-05 0.000183 One 605 ECSIT_4 0.0000000000 0.00023954975788706846 7.566489045169451e-08 0.00024 One 606 KCTD11_5 0.0000000000 0.0002424331083574083 3.522356648205783e-06 0.000242 One 607 NOL4_1 0.0000000729 0.0002459835698877307 6.791821030730467e-07 0.000246 One 608 PHACTR3_1 0.0000000457 0.0002459835698877307 0.00011686809560116665 0.000246 One 609 RTN1_1 0.0000006098 0.0002459835698877307 4.222711647559608e-07 0.000246 One 610 STMN2_1 0.0000012964 0.0002459835698877307 4.094884978838306e-05 0.000246 One 611 AP2S1_2 0.0000000002 0.0002471622654017496 1.0198622949899072e-05 0.000247 One 612 ZFYVE21_1 0.0000194549 0.00025234279143195943 5.133817635619759e-06 0.000252 One 613 UNC13A_1 0.0000014726 0.00028614552404424633 2.0145584910723037e-05 0.000286 One 614 HRH3_2 0.0000000245 0.00028947620258979817 6.225133521987448e-05 0.000289 One 615 SLC46A3_1 0.0000004395 0.00029139375190295606 3.1273990762894294e-06 0.000291 One 616 FANCF_1 0.0000011239 0.00029389877591584477 0.00014597857403495873 0.000294 One 617 NUP188_1 0.0000001812 0.0003007412862887539 4.955407744532583e-06 0.000301 One 618 RASL11B_4 0.0000000000 0.00031499165163320023 4.227422993905127e-06 0.000315 One 619 RPL35A_1 0.0000009189 0.0003258993441790789 7.814046683768043e-08 0.000326 One 620 MRPS34_2 0.0000000002 0.0003472766416957016 2.882909993280601e-07 0.000347 One 621 GIMAP2_3 0.0000000036 0.0003570706360030332 0.00045579260491531034 0.000357 One 622 CEP290_2 0.0000000344 0.00037108570224806444 2.0125145944135785e-07 0.000371 One 623 GLTPD1_2 0.0000000118 0.0003718951957804949 0.0006320584367733676 0.000372 One 624 GPHN_2 0.0000000007 0.0003773923191660758 5.22047699300538e-06 0.000377 One 625 CASP1_1 0.0000000068 0.00037839447623271325 6.1495186991073225e-09 0.000378 One 626 ZNF696_1 0.0000000962 0.00037839447623271325 2.4615255354876653e-06 0.000378 One 627 PUM2_1 0.0000026305 0.0003816779304374477 3.3222971313684545e-07 0.000382 One 628 MEIS1_3 0.0000004107 0.0003904462676161654 0.0007682186961292422 0.00039 One 629 IFI30_1 0.0000012163 0.00040506375286474184 9.574423734042937e-07 0.000405 One 630 IL11RA_1 0.0000001170 0.0004052971561229435 2.655673357753088e-06 0.000405 One 631 NUCB2_1 0.0000013611 0.0004052971561229435 5.5618984098014e-07 0.000405 One 632 PTP4A3_1 0.0000000680 0.0004052971561229435 5.887768664427049e-08 0.000405 One 633 ADRBK2_2 0.0000000000 0.0004093391300622974 1.5783568509062198e-06 0.000409 One 634 PKIG_3 0.0000000000 0.00041171580743841403 3.057193996659834e-08 0.000412 One 635 SET_2 0.0000000001 0.0004229662691805196 1.4462314562288453e-05 0.000423 One 636 FLII_4 0.0000000000 0.000424309729157916 2.721972050662147e-05 0.000424 One 637 ARF6_1 0.0000010688 0.00044644151159829265 4.777162467883633e-05 0.000446 One 638 HMGCR_1 0.0000039108 0.0004491267996311823 9.51430189572535e-06 0.000449 One 639 ST8SIA3_1 0.0000019568 0.0004491267996311823 4.900547697748023e-06 0.000449 One 640 UNC80_1 0.0000008226 0.0004491267996311823 1.005782022353512e-07 0.000449 One 641 CCT8_3 0.0000000347 0.00045011610035894004 2.032003598923382e-06 0.00045 One 642 TRIM28_1 0.0000148486 0.00045014028192995044 3.949110489775901e-06 0.00045 One 643 CDC25A_2 0.0000000098 0.0004534776514099725 1.5512971032931264e-06 0.000453 One 644 GLTP_2 0.0000000028 0.00046494643788992516 5.8185552156116945e-06 0.000465 One 645 CCDC77_1 0.0000004612 0.0004974933526793384 4.507699749268401e-07 0.000497 One 646 MCF2L_1 0.0000000690 0.0005027123562350216 7.202072224189724e-07 0.000503 One 647 SLC6A2_2 0.0000001185 0.000506059688566897 2.28692972901338e-08 0.000506 One 648 SYP_2 0.0000001356 0.000506059688566897 6.3185873271940225e-06 0.000506 One 649 CNOT6_1 0.0000013898 0.0005152101842532016 1.3714419618221151e-06 0.000515 One 650 VARS_1 0.0000000157 0.0005152101842532016 6.389630116189804e-11 0.000515 One 651 IFITM3_4 0.0000000000 0.0005174358092289639 1.9647037009697173e-05 0.000517 One 652 PEX5_1 0.0000022882 0.0005345944155461007 2.4708316986247094e-07 0.000535 One 653 SLC31A2_2 0.0000000257 0.0005474521677410701 1.2568064895404654e-06 0.000547 One 654 GRIK3_1 0.0000076075 0.0005728902408745853 5.005291812592071e-05 0.000573 One 655 VN1R1_1 0.0000028939 0.0006456808009902826 1.5945573929220053e-06 0.000646 One 656 TFB2M_1 0.0000001636 0.0006554884190714251 8.29128842666871e-07 0.000655 One 657 MAD2L1_1 0.0000002657 0.000678865345560909 0.00022984708856661868 0.000679 One 658 MCM7_1 0.0000003921 0.000678865345560909 2.3157502863099238e-08 0.000679 One 659 MLF1IP_1 0.0000001155 0.000678865345560909 1.6356325391481808e-06 0.000679 One 660 RFC3_1 0.0000001961 0.000678865345560909 1.1405622586556333e-05 0.000679 One 661 RPL13A_5 0.0000000036 0.0006975780500730752 2.039076211055246e-07 0.000698 One 662 LINGO2_5 0.0000000000 0.0007331284191550658 3.7702692631153038e-06 0.000733 One 663 DNAJC22_1 0.0000621331 0.0007382242549827655 0.000384678461175607 0.000738 One 664 LAPTM4B_5 0.0000000199 0.0008008831004583888 1.799793994988323e-08 0.000801 One 665 MRPL21_1 0.0000002469 0.000813643911578377 2.155726402205982e-11 0.000814 One 666 KBTBD6_5 0.0000000012 0.0008752905126922217 5.094541684026646e-07 0.000875 One 667 ENDOD1_1 0.0000010618 0.0009656194251740187 1.0198902416156784e-06 0.000966 One 668 DYNLT3_1 0.0000002295 0.0009791477447292118 3.4005766399654322e-06 0.000979 One 669 FBXO33_3 0.0000001392 0.00103117959256628 0.0005017044994385344 0.001031 One 670 MAGT1_3 0.0000000006 0.0011183473761450665 3.282773317248208e-06 0.001118 One 671 RAP2C_1 0.0000000589 0.0012216917856767418 2.1738080076458742e-06 0.001222 One 672 UNC13A_4 0.0000000000 0.0012433758358174857 1.4243994675867104e-05 0.001243 One 673 MFAP5_1 0.0000031279 0.0012466841325621532 3.1380128368492257e-06 0.001247 One 674 CUX2_2 0.0000000011 0.001257136009743649 7.431311834991675e-07 0.001257 One 675 MED25_5 0.0000000204 0.001313200027316744 1.4936727700519996e-05 0.001313 One 676 MYT1L_2 0.0000000108 0.0013890971495074075 1.0025847658579697e-06 0.001389 One 677 TMEM18_2 0.0000076695 0.0013942235684900853 1.707287632066412e-07 0.001394 One 678 CCT7_1 0.0000001734 0.001443320215490813 1.1968773859770425e-09 0.001443 One 679 MAK16_1 0.0000004814 0.001443320215490813 2.3072064933343512e-09 0.001443 One 680 MRPS21_1 0.0000000540 0.001443320215490813 6.719016265932361e-09 0.001443 One 681 POLR1B_1 0.0000003351 0.001443320215490813 1.7793565095841775e-08 0.001443 One 682 GTPBP1_2 0.0000000021 0.001459680524809358 0.00015614452037923833 0.00146 One 683 EBF3_1 0.0000010072 0.0014691176249919573 8.044891819455788e-07 0.001469 One 684 MTUS1_2 0.0000935307 0.0015509534579936969 1.105438193098732e-06 0.001551 One 685 NUP133_2 0.0000000014 0.0015899100236963135 1.3303993388626396e-05 0.00159 One 686 CTNND1_2 0.0000000000 0.001732526914901912 3.072309330628804e-05 0.001733 One 687 NDUFB9_1 0.0000000238 0.0017523496068642189 5.3915212453729005e-09 0.001752 One 688 SLC9A7_1 0.0000003133 0.0017523496068642189 1.2535099503914342e-05 0.001752 One 689 EIF4ENIF1_1 0.0000108333 0.0017678348648425643 3.7197697739906752e-06 0.001768 One 690 DOCK1_1 0.0000181948 0.001772102755233229 1.4070332453720584e-06 0.001772 One 691 RPL32_1 0.0000022322 0.001777378099890663 6.225050246986396e-05 0.001777 One 692 PRICKLE2_1 0.0000006847 0.0018473350729729212 2.0385221521213067e-05 0.001847 One 693 RUFY3_1 0.0000070188 0.0018473350729729212 1.8701260489318547e-05 0.001847 One 694 WNT5A_1 0.0000028497 0.0018473350729729212 2.708727992064078e-06 0.001847 One 695 MPHOSPH10_2 0.0000000007 0.0018678908445817427 1.5239795553355398e-06 0.001868 One 696 ARID3A_1 0.0000002399 0.0019027179320774803 5.715891598653691e-07 0.001903 One 697 HBQ1_1 0.0000006406 0.0019027179320774803 6.157621558231056e-07 0.001903 One 698 CAPG_5 0.0000000000 0.001947090513575717 7.749723393890698e-06 0.001947 One 699 YARS2_2 0.0005979379 0.0019907006334396776 5.679834094373692e-07 0.001991 One 700 KIAA0247_5 0.0000000008 0.001994915026343904 7.399520670189372e-07 0.001995 One 701 ATP6V1A_1 0.0000002721 0.0020456136275657888 5.629476223876873e-08 0.002046 One 702 NFXL1_3 0.0000000000 0.0020758764777589786 5.099976094773998e-07 0.002076 One 703 RIOK3_3 0.0000000003 0.0021500812901470065 0.00030023156807518783 0.00215 One 704 AKR7A2_4 0.0000000023 0.0021553658383185563 2.358890665005359e-05 0.002155 One 705 THOC1_3 0.0000009047 0.002194182322111777 0.00021664763805975321 0.002194 One 706 COPG_1 0.0000003427 0.0021961385175434875 8.880302868410324e-08 0.002196 One 707 RPL13_1 0.0000004776 0.002391299161389133 4.361906742412738e-06 0.002391 One 708 ARRB2_2 0.0000000003 0.0024223436617129856 8.170313945294133e-05 0.002422 One 709 CCDC41_2 0.0000005081 0.0024621645703630526 1.7620046187445725e-05 0.002462 One 710 WDR75_5 0.0000000001 0.0024742390938208743 2.813266963497791e-07 0.002474 One 711 LRBA_4 0.0000000000 0.002519709257235862 0.0002137598179932144 0.00252 One 712 BAI3_2 0.0000000007 0.002579529817958645 3.1862597515464765e-08 0.00258 One 713 FKBP4_1 0.0000009273 0.0026665845796536394 3.954836683246733e-07 0.002667 One 714 H3F3B_1 0.0000006090 0.0026665845796536394 1.0621184124507563e-07 0.002667 One 715 LRRC45_1 0.0000035848 0.002695070404947365 0.005476743217592932 0.002695 One 716 VPRBP_1 0.0000098159 0.0028451265399304145 0.00033046637508825843 0.002845 One 717 KIF1A_1 0.0000002287 0.002859168680149655 7.313472575923523e-07 0.002859 One 718 RPL3_1 0.0001386435 0.0028919508671728217 4.887776236374372e-07 0.002892 One 719 ABI3BP_1 0.0000085821 0.003065043011644369 1.0951385360313097e-07 0.003065 One 720 FBRSL1_1 0.0000038191 0.0030838618137353662 2.4058708516257493e-06 0.003084 One 721 RAB3C_1 0.0000001743 0.0030838618137353662 2.7538671921394696e-07 0.003084 One 722 C16orf59_1 0.0000000275 0.0031574556401693433 1.5986180058945153e-05 0.003157 One 723 NUP35_1 0.0000004963 0.0031574556401693433 1.514239152011962e-06 0.003157 One 724 LPIN2_1 0.0000098827 0.0034466689399791843 2.452952119077932e-06 0.003447 One 725 ZNF507_2 0.0000000111 0.003820596558681088 0.00011453249175240676 0.003821 One 726 ADAM10_1 0.0000233014 0.0038798255226726924 6.64776252928381e-06 0.00388 One 727 FBXL18_1 0.0000066755 0.0038798255226726924 7.005071001453964e-05 0.00388 One 728 TMOD3_1 0.0000078430 0.0038798255226726924 1.2077163895524178e-08 0.00388 One 729 HLCS_3 0.0000000014 0.003897587461379324 6.778958570865246e-05 0.003898 One 730 NYNRIN_1 0.0000000051 0.0040253432504568695 5.327811563265487e-06 0.004025 One 731 PDXK_1 0.0000012454 0.0041233566091711665 6.342148817937973e-09 0.004123 One 732 RPS11_3 0.0000000443 0.0043239457542860625 1.7167121527934926e-08 0.004324 One 733 LCE2B_1 0.0000000888 0.004326577770871151 8.013095879242094e-06 0.004327 One 734 MAP2K7_3 0.0000000490 0.004508166201072404 3.487700085903893e-07 0.004508 One 735 PATZ1_1 0.0000004164 0.004557941079021841 3.004553790169959e-08 0.004558 One 736 SMCR7L_1 0.0000000162 0.004557941079021841 1.0835431093170762e-07 0.004558 One 737 CNTNAP2_1 0.0000001099 0.004613449756294485 2.310283526460759e-05 0.004613 One 738 SLC29A3_1 0.0000003134 0.004613449756294485 4.496266117362092e-06 0.004613 One 739 ZBTB34_1 0.0000040446 0.004618680063226724 8.498577839821885e-07 0.004619 One 740 PRKAA1_2 0.0000001321 0.004627796941857709 5.55517925893019e-06 0.004628 One 741 IRF1_2 0.0000000003 0.004777571752988573 6.77745840075317e-08 0.004778 One 742 GDAP1L1_5 0.0000000002 0.004808546917289599 1.5091907669172042e-06 0.004809 One 743 NUP205_2 0.0000009871 0.004863314597556403 0.0012109741287245038 0.004863 One 744 NUS1_1 0.0000000240 0.005366950975922179 3.380290864221785e-05 0.005367 One 745 GOLT1B_3 0.0000022695 0.005599828148522198 3.3515801939710514e-08 0.0056 One 746 SEC24A_2 0.0000000249 0.005701481885121388 7.068590877915707e-08 0.005701 One 747 AVEN_1 0.0000004065 0.005953586357194907 1.3650737340980481e-05 0.005954 One 748 BRD3_1 0.0000002324 0.0060047412034100744 7.118719879444557e-05 0.006005 One 749 CBX5_1 0.0000008271 0.0060047412034100744 2.073650192477865e-07 0.006005 One 750 ZNF689_1 0.0000000501 0.006037283839286274 8.7110715845335e-07 0.006037 One 751 RHOG_5 0.0000003561 0.006148753448353471 4.9151555577284784e-05 0.006149 One 752 SPRY1_4 0.0000003345 0.006174801125444205 0.0033247321236384107 0.006175 One 753 NR1H2_2 0.0000000004 0.006201080908802092 7.565957176888148e-05 0.006201 One 754 RTKN2_1 0.0000066891 0.006287821872432228 2.618709167085205e-06 0.006288 One 755 CHRNA5_1 0.0000056104 0.006387086743044337 1.5554788280693852e-06 0.006387 One 756 PEBP1_1 0.0000011028 0.006389356754277303 3.377019522860942e-08 0.006389 One 757 CNOT6_1 0.0000000995 0.0064218708869592965 1.2731573046468182e-07 0.006422 One 758 FEM1B_1 0.0000014595 0.006512658184422679 1.2419959836180664e-05 0.006513 One 759 PDCD2L_1 0.0000198400 0.006732981542919481 7.754024385726151e-07 0.006733 One 760 BCCIP_2 0.0000000036 0.006993057619665846 1.8570072163956842e-07 0.006993 One 761 C17orf80_2 0.0000003489 0.007022396430063894 9.534705566156907e-06 0.007022 One 762 TMEM229A_1 0.0000014642 0.007033451966587178 4.488027198291259e-06 0.007033 One 763 AKAP1_1 0.0000048789 0.007054606953047138 2.2520683380861938e-08 0.007055 One 764 EPC2_1 0.0000187282 0.007054606953047138 3.1361338152693263e-06 0.007055 One 765 FKBP14_1 0.0000001541 0.007054606953047138 5.2000405163879345e-08 0.007055 One 766 HMGB1_1 0.0000243369 0.007054606953047138 3.5582530664664353e-06 0.007055 One 767 TMEM167B_1 0.0000089984 0.007054606953047138 4.903843719615824e-08 0.007055 One 768 FURIN_1 0.0000013583 0.007154235078360664 0.0024498354764936592 0.007154 One 769 FUZ_2 0.0000000010 0.007484149048900862 8.06345585283052e-07 0.007484 One 770 RAX_1 0.0000005607 0.007849325275374927 1.5165025207033165e-06 0.007849 One 771 HSPA5_1 0.0000233798 0.00804650712219702 3.3345569936160264e-07 0.008047 One 772 SEZ6_1 0.0000001552 0.00809133905523077 2.1206134094154278e-05 0.008091 One 773 CDC7_2 0.0000090196 0.00818484412008511 5.21476362116686e-05 0.008185 One 774 TIMELESS_2 0.0000000005 0.008348387787825583 1.1506564136074267e-05 0.008348 One 775 FAIM2_1 0.0000004595 0.008633031029057705 7.868329291267168e-08 0.008633 One 776 PKIA_1 0.0000117746 0.008813705248904322 1.6109769990275906e-08 0.008814 One 777 MRFAP1L1_1 0.0000000173 0.009220967328515883 2.2849973360661935e-07 0.009221 One 778 SLC4A8_1 0.0000432316 0.010311927011747773 2.2746479512952496e-06 0.010312 One 779 SAMM50_1 0.0000040988 0.010582443118030336 5.607191574381122e-07 0.010582 One 780 FAM129A_1 0.0000110292 0.010610163045225487 0.00021553454881793465 0.01061 One 781 AFMID_5 0.0000000000 0.011037504835486236 6.903237042102531e-06 0.011038 One 782 STARD7_1 0.0000008193 0.011230798403991177 1.4750425191704724e-06 0.011231 One 783 GPN2_2 0.0000000003 0.011286646172223367 0.0002020338349948365 0.011287 One 784 PCDH9_1 0.0000115514 0.01159836162693171 2.5431326048421465e-05 0.011598 One 785 DDOST_2 0.0000006862 0.011732466260948907 7.712332840561586e-07 0.011732 One 786 TMEM109_3 0.0000000174 0.01179210198130457 1.34476580166563e-05 0.011792 One 787 OLA1_2 0.0000001004 0.01186517030330062 3.4419370304963574e-06 0.011865 One 788 RGS3_4 0.0000000707 0.012273010269850448 8.926332727725615e-07 0.012273 One 789 HMGCL_1 0.0000057648 0.013135841653707197 6.151145606016247e-07 0.013136 One 790 SIPA1L1_1 0.0000004161 0.013135841653707197 1.518269230551228e-06 0.013136 One 791 TMEM50A_1 0.0000006936 0.013135841653707197 2.3186309995661696e-05 0.013136 One 792 AP2S1_2 0.0005534120 0.013321879037458757 2.1009217572593065e-05 0.013322 One 793 NARF_1 0.0000001706 0.01356093601279795 7.558805657306656e-07 0.013561 One 794 S100A2_2 0.0000000045 0.013795138693676535 0.0009724391668072714 0.013795 One 795 STX8_2 0.0010456927 0.013842934358702711 6.244242975666368e-07 0.013843 One 796 SLC10A4_3 0.0000000008 0.0147620266284032 0.00012936185099713163 0.014762 One 797 KCNAB1_1 0.0000177047 0.014856183619266723 1.5321385429315337e-05 0.014856 One 798 NUFIP1_1 0.0000040928 0.015328857071669418 1.4820509456787599e-05 0.015329 One 799 PUS7_1 0.0002258870 0.015382714940475899 0.0003699975490667046 0.015383 One 800 TMEM33_1 0.0000021939 0.015382714940475899 7.8917032520098e-05 0.015383 One 801 SUPT4H1_1 0.0000076733 0.015545833082593517 3.111378512146274e-05 0.015546 One 802 B4GALT1_2 0.0000000036 0.015866838196212218 4.984509522594122e-08 0.015867 One 803 TRMT1_1 0.0000002555 0.016113877031426083 3.5979546226837025e-05 0.016114 One 804 ITCH_1 0.0000006285 0.016311084928625978 3.67059506817032e-06 0.016311 One 805 SLC41A2_1 0.0000027434 0.016829575684385905 0.0002722352435422239 0.01683 One 806 UBXN1_1 0.0000006760 0.01695446499444467 2.7446548902174226e-06 0.016954 One 807 AARS2_1 0.0000130548 0.017241329872294712 5.7037625716450966e-05 0.017241 One 808 ASB13_1 0.0000238679 0.017330336075027382 4.6209737153601604e-07 0.01733 One 809 CSDA_1 0.0000009251 0.017443397981769932 0.0011464157798244399 0.017443 One 810 DBH_1 0.0000079113 0.017443397981769932 1.4347684455753113e-06 0.017443 One 811 DOK4_1 0.0000231034 0.017443397981769932 6.618729332114159e-06 0.017443 One 812 FAM57B_1 0.0000016227 0.017443397981769932 5.886088725233178e-06 0.017443 One 813 GRIA4_1 0.0000003095 0.017443397981769932 2.302309309599117e-05 0.017443 One 814 IGFBPL1_1 0.0000008576 0.017443397981769932 4.783176130914827e-07 0.017443 One 815 NFKBIZ_1 0.0000162804 0.017443397981769932 3.3994720134388014e-06 0.017443 One 816 PIEZO1_1 0.0000001897 0.017443397981769932 1.8246285080698113e-06 0.017443 One 817 SCN3B_1 0.0000011607 0.017443397981769932 1.5135394267848417e-06 0.017443 One 818 SNAP91_1 0.0000071468 0.017443397981769932 2.638244061314773e-07 0.017443 One 819 TMEM151B_1 0.0000049076 0.017443397981769932 2.6430931809230297e-05 0.017443 One 820 TRAM1_1 0.0000027969 0.017443397981769932 1.6694679799715998e-06 0.017443 One 821 DLGAP2_1 0.0000034653 0.017999463759106323 2.855153777346279e-05 0.017999 One 822 GFRA2_2 0.0000000003 0.018137077932381954 0.000951735145248877 0.018137 One 823 C12orf44_5 0.0000000000 0.018866742690223485 8.109600906363036e-06 0.018867 One 824 CPD_2 0.0000000009 0.018958927953712085 1.967423231238389e-05 0.018959 One 825 UNG_3 0.0000000006 0.019815116785847253 0.00017623188278973096 0.019815 One 826 AGAP2_1 0.0000012045 0.020393810250137884 8.442387558423992e-06 0.020394 One 827 DPY19L4_1 0.0000013827 0.020459674602965643 1.4759797172005466e-06 0.02046 One 828 UST_1 0.0000248242 0.020499190298611462 6.68339412744453e-08 0.020499 One 829 MAP2K7_1 0.0000028217 0.020602652898910816 1.2164780555581337e-05 0.020603 One 830 DLG1_1 0.0000000204 0.02077959376727299 9.890664601929713e-06 0.02078 One 831 MAPK8IP2_1 0.0000001600 0.021209400010728994 1.2744882761058085e-05 0.021209 One 832 TARDBP_3 0.0000000007 0.021265954498108135 6.908159765653427e-06 0.021266 One 833 CYLD_1 0.0000000217 0.0214858173069357 9.879543686944467e-07 0.021486 One 834 ATL2_1 0.0000013494 0.021736958168253658 8.154925885406086e-06 0.021737 One 835 SCAMP5_1 0.0000005258 0.02223324975104475 6.003509085007509e-09 0.022233 One 836 ARL6IP5_1 0.0000000067 0.02225726819150785 1.956141813979619e-06 0.022257 One 837 TUBD1_1 0.0000003011 0.02263296125661172 7.713138636684567e-05 0.022633 One 838 OLFM3_1 0.0000089344 0.022851610694445912 1.8829513375080384e-05 0.022852 One 839 ODC1_2 0.0000008568 0.022971832631374724 2.7504995269216484e-06 0.022972 One 840 EXOSC8_4 0.0000000000 0.022989772746273066 0.0001824993302681246 0.02299 One 841 GEMIN5_4 0.0000000017 0.023273422660848357 7.022368029898661e-07 0.023273 One 842 BCLAF1_1 0.0000031831 0.023433853775319136 1.6892927173134977e-06 0.023434 One 843 ADAMTSL2_3 0.0000000000 0.02345493378746214 2.0324998641713588e-05 0.023455 One 844 GSDMD_1 0.0003698567 0.02361947064385562 1.260266686331163e-05 0.023619 One 845 FILIP1L_1 0.0000442945 0.02380535004803143 4.139244014504424e-06 0.023805 One 846 MPP5_1 0.0000013996 0.024393557193549072 5.899482289097565e-07 0.024394 One 847 ZNF781_2 0.0000000214 0.024442804805679837 0.0002430481092405698 0.024443 One 848 GREB1_1 0.0000021946 0.025082579510674555 1.026168781803766e-06 0.025083 One 849 MICAL2_1 0.0000051045 0.025082579510674555 5.460450875355455e-06 0.025083 One 850 MLKL_1 0.0000245887 0.02520256529276301 1.5181921351787456e-07 0.025203 One 851 HIATL1_1 0.0000001697 0.025698116096895575 0.0006037318193258467 0.025698 One 852 POFUT2_3 0.0000002159 0.025815308401600554 3.356964828070045e-08 0.025815 One 853 FSD1L_3 0.0000000005 0.026091908369487455 0.00039856129823143474 0.026092 One 854 SLC22A4_1 0.0000007929 0.026358068088106524 5.592144002080514e-06 0.026358 One 855 ECE1_1 0.0000040064 0.027281965933944777 3.1606809203074195e-06 0.027282 One 856 FAM120C_1 0.0000001526 0.027478094280566072 9.440653359830993e-06 0.027478 One 857 WDR18_1 0.0000002870 0.02811272649847224 2.0929795909688486e-06 0.028113 One 858 SPAST_2 0.0000001330 0.028348027782966405 3.9367533477728655e-06 0.028348 One 859 RIN2_1 0.0000003608 0.028653860870043152 1.4769971196556159e-05 0.028654 One 860 RUNX2_2 0.0000000005 0.028974052520507214 2.14065240634782e-06 0.028974 One 861 NOP14_2 0.0000005983 0.02901206601493043 9.523685001792411e-07 0.029012 One 862 MAN2B2_1 0.0000027972 0.029245906890336886 1.4933063823416558e-06 0.029246 One 863 PAIP1_1 0.0000007230 0.029320244216402155 2.7441426734443414e-07 0.02932 One 864 DHX32_2 0.0000533846 0.029344624633688917 6.043863871216864e-07 0.029345 One 865 PLK2_2 0.0002388183 0.029905384844343543 2.063197005965159e-06 0.029905 One 866 PRCC_1 0.0000001861 0.029926219059845965 1.1405008131610388e-06 0.029926 One 867 XAF1_1 0.0000358261 0.030280074734233196 7.286165792821834e-08 0.03028 One 868 METAP2_1 0.0000087458 0.030556265901493518 3.240583308159839e-07 0.030556 One 869 CLK2_1 0.0000011413 0.030888289103249412 7.675595673276064e-06 0.030888 One 870 DPP6_1 0.0000000203 0.03100397440582499 5.0469470139700276e-05 0.031004 One 871 ACSL4_3 0.0000020398 0.03149060869705135 1.5068270568910291e-05 0.031491 One 872 ANKIB1_1 0.0000005533 0.032332967518234994 5.693423471624403e-07 0.032333 One 873 MRPL44_1 0.0000004285 0.03320176795710607 7.58534516483232e-07 0.033202 One 874 ECSIT_1 0.0000000613 0.033538144332397844 9.327207467647707e-06 0.033538 One 875 UTRN_1 0.0000011107 0.033538144332397844 2.5789968645189164e-06 0.033538 One 876 KLHL3_1 0.0000383917 0.0344114911006157 3.244555435191599e-05 0.034411 One 877 PPP3CC_1 0.0004859138 0.03515778354911297 6.188875946486586e-05 0.035158 One 878 ZNF146_2 0.0000000002 0.03744996129971014 0.00011861207253864054 0.03745 One 879 ZNF561_1 0.0000000634 0.03880023351870834 2.016596236878262e-06 0.0388 One 880 GABRB3_2 0.0000004163 0.03908988372883462 1.4145265356070185e-06 0.03909 One 881 FUCA2_2 0.0000010455 0.040900774628950205 4.509971577380666e-08 0.040901 One 882 ZNF704_1 0.0000003968 0.04141199786610875 3.2915671737970186e-07 0.041412 One 883 RSRC2_1 0.0000006681 0.04263760212726399 8.124905418115654e-06 0.042638 One 884 ZNF786_4 0.0000003689 0.04302185346161887 0.00017227082461867952 0.043022 One 885 FAM208A_4 0.0000001168 0.04317698799820883 6.901563255423604e-06 0.043177 One 886 KLC1_2 0.0000000029 0.04326421162343569 9.50085593569108e-05 0.043264 One 887 C4orf46_1 0.0000014299 0.04398087969459366 0.0001711178965703045 0.043981 One 888 PFDN2_1 0.0000002586 0.044291333594155616 1.8451067079767974e-09 0.044291 One 889 TMEM88_1 0.0000001338 0.04436920294909983 3.529178026304605e-07 0.044369 One 890 CAMKMT_1 0.0000058447 0.045390286722626634 3.532704674941749e-05 0.04539 One 891 RAB3A_5 0.0000000000 0.04677739444487693 1.0728714113996382e-05 0.046777 One 892 PPP1R3C_1 0.0000160727 0.046988563883468094 6.183139691881509e-07 0.046989 One 893 RNPS1_1 0.0000017303 0.04934110523099186 2.7030460144558537e-06 0.049341 One 894 SESN1_1 0.0000827949 0.049980571686550485 0.00013996827329482083 0.049981 One

Table 8 lists the FRHs associated with head and neck drugs and the markers that define the head and neck cancer drugs and FRHs associated with them.

In addition, [Table 9] summarizes the results of calculating the degree of reactivity (P-value) of FRHs shown in [Table 8].

In these tables, FRH is expressed in the form of "FRH name_number of included markers", and "Var_Exp (pval)" means the correlation (Pvlaue) value of each marker on the corresponding gene expression, and "Var_Drug (pval)" Means the correlation (Pvlaue) value of the corresponding marker on the reactivity of the drug, and according to the order of the drugs listed in [Table 8], the reactivity correlation values for each drug are divided into the classification factor 『/』 `` Exp_Drug (pval) '', the gene expression has a correlation (Pvlaue) value for drug reactivity according to the order of drugs listed in [Table 8], and "Ave_VarDrug (pval)" is "Var_Drug ( pval) 』means the mean of the calculated values, and『 Rank 』means the number of head and neck cancer drugs that the FRH significantly affects.

From these reactivity verification results, the lower the Var_Exp (pval), the lower the Var_Drug (pval) and its average value, Ave_VarDrug (pval), the lower the Exp_Drug (pval), the higher the Rank number, the corresponding marker determines drug reactivity It can be judged that the effectiveness is high as a biomarker.

On the other hand, in FIG. 31, correlation values (P-vlaue) values of the head and neck cancer drugs of the major biomarkers among the biomarkers listed in Table 8 are graphically displayed, and FIG. 32 shows genes expressed by the main biomarkers. The correlation values (P-vlaue) values for both the head and neck cancer drugs are plotted.

Reactive biomarker for head & neck drugs No. FRH Drug DrugType Var (marker) One RAI14_2 60_BI-2536 / 87_GW843682X / 150_Bicalutamide / 155_AP-24534 / 269_NSC-207895 / 295_NVP-BHG712 / 341_EX-527 / 1016_Temsirolimus / 1032_Afatinib / 1036_PLX4720 / 1057_NVP-BEZ235 / 1061_1212 5Z) -7-Oxozeaenol / 1371_PLX4720 (rescreen) / 1372_Trametinib / 1373_Dabrafenib / 1377_Afatinib (rescreen) mitosis / mitosis / other / abl / p53 / rtk / other / tor / egfr / erk_mapk / pi3k / erk_mapk / g_integrity / chromatin / wnt / other / erk_mapk / erk_mapk / erk_mapk / egfr 14_21082261_T_G / 7_140753336_A_T 2 ELK3_1 1373_Dabrafenib_1 / 1242_ (5Z) -7-Oxozeaenol_3 / 1526_Refametinib_3 / 1371_PLX-4720_3 / 1372_Trametinib_1 erk_mapk / other / erk_mapk / erk_mapk / erk_mapk 14_21082261_T_G 3 RAI14_2 1373_Dabrafenib_1 / 1371_PLX-4720_3 / 1242_ (5Z) -7-Oxozeaenol_3 erk_mapk / erk_mapk / other 14_21082261_T_G / 5_94871301_T_G 4 NOTCH2_1 1371_PLX-4720_3 / 1373_Dabrafenib_1 / 1242_ (5Z) -7-Oxozeaenol_3 erk_mapk / erk_mapk / other 20_63940084_T_G 5 CATSPER1_1 1373_Dabrafenib_1 / 1242_ (5Z) -7-Oxozeaenol_3 erk_mapk / other 7_140753336_A_T 6 TNIP1_2 1373_Dabrafenib_1 / 1371_PLX-4720_3 erk_mapk / erk_mapk 5_154823483_T_G / 15_32616231_T_G 7 PTX3_2 1373_Dabrafenib_1 / 1242_ (5Z) -7-Oxozeaenol_3 erk_mapk / other 7_140753336_A_T / 14_21082261_T_G 8 ZHX3_1 1373_Dabrafenib_1 / 1242_ (5Z) -7-Oxozeaenol_3 erk_mapk / other 7_72926354_C_T 9 SH2D3A_1 1010_Gefitinib_1 / 1377_Afatinib_1 egfr / egfr 6_129475475_C_T 10 SLC39A13_5 1373_Dabrafenib_1 / 1242_ (5Z) -7-Oxozeaenol_3 erk_mapk / other 14_21082261_T_G / 7_140753336_A_T / 11_85724752_T_C / 3_48790461_T_G / 17_35259011_T_G 11 GJB6_1 1032_Afatinib_1 / 1114_Cetuximab_1 egfr / egfr 1_44978366_G_A 12 PLAU_2 1494_SN-38_3 / 1259_Talazoparib_3 DNArep / g_integrity 16_2519752_T_C / 9_114307582_T_G 13 ATG7_1 1373_Dabrafenib_1 erk_mapk 7_140753336_A_T 14 CACNG4_3 1373_Dabrafenib_1 erk_mapk 7_140753336_A_T / 16_11174168_A_G / 6_5771301_A_C 15 GJB2_1 1032_Afatinib_1 egfr 1_44978366_G_A 16 DOCK4_2 1373_Dabrafenib_1 erk_mapk 9_76227464_A_G / 7_140753336_A_T 17 AP1M2_3 1377_Afatinib_1 egfr 1_2521130_T_C / 12_50718803_T_C / 1_2491175_G_A 18 RNF216_1 1021_Axitinib_2 rtk 10_45443298_C_T 19 IRX2_3 1373_Dabrafenib_1 erk_mapk 1_2562891_G_A / 12_14460981_T_A / 7_140753336_A_T 20 CXADR_4 1242_ (5Z) -7-Oxozeaenol_3 other 14_21082261_T_G / 3_47333236_T_C / 18_8387094_T_G / 17_63831142_T_G 21 NEBL_1 1242_ (5Z) -7-Oxozeaenol_3 other 7_72926354_C_T 22 FXYD3_1 1032_Afatinib_1 egfr 22_50625559_G_C 23 SERPINB5_1 1032_Afatinib_1 egfr 22_50625559_G_C 24 GJB3_1 1010_Gefitinib_1 egfr 6_129475475_C_T 25 GJB5_1 1010_Gefitinib_1 egfr 6_129475475_C_T 26 WNT10A_1 1010_Gefitinib_1 egfr 6_129475475_C_T 27 ACLY_1 255_CP724714_2 egfr 15_26976868_T_A 28 KRT6A_1 1114_Cetuximab_1 egfr 22_50576781_G_C 29 PRADC1_1 1037_BX796_2 other 2_53899904_C_T 30 TIMP1_1 1373_Dabrafenib_1 erk_mapk 19_9985806_C_T 31 GYLTL1B_2 1032_Afatinib_1 egfr 7_5938011_C_CCA / 7_5945090_C_T 32 PTCHD4_4 1373_Dabrafenib_1 erk_mapk 11_4102115_C_G / 11_4132537_A_G / 11_4112087_C_A / 11_4138236_G_A

Results of verification of biomarker responsiveness to head & neck drug No. FRH Var_Exp (pval) Var_Drug (pval) Exp_Drug (pval) Ave_VarDrug (pval) Rank One RAI14_2 1.50E-07 0.002427316 / 0.007905787 / 0.009050202 / 0.008885028 / 0.006973327 / 0.008993803 / 0.006448846 / 0.003370265 / 0.005536324 / 7.23E-05 / 0.008957232 / 0.006831953 / 0.007786364 / 0.009533459 / 0.002310426 / 0.006104376 / 2.92E-05 / 0.003064818 / 1.61E05 0.07094644 / 0.187614118 / 0.000121399 / 0.070569119 / 0.006038396 / 0.070019258 / 0.001656899 / 0.051790523 / 0.024868194 / 0.001587975 / 0.005704322 / 0.20488317 / 0.010104768 / 0.019630304 / 0.019900005 / 1.24E-05 / 2.38E-05 / 0.00050772 / 1.09E-06 0.00571 20 2 ELK3_1 0.0000051495 8.520565972551354e-05 / 0.015525162300909256 / 0.022555240944218617 / 9.519623606517973e-05 / 0.007329786178994242 1.490382050697451e-07 / 5.969489582574335e-06 / 6.8362891216619816e-06 / 9.005519185972905e-06 / 6.49148403527597e-05 0.009118 5 3 RAI14_2 0.0000000017 0.0008802720058814783 / 4.733202001463438e-05 / 0.011225192753415226 1.0853407136502757e-06 / 2.4863984008159652e-05 / 1.2422979331681213e-05 0.004051 3 4 NOTCH2_1 0.0003642485 0.0022063266509928054 / 0.0011467762666252258 / 0.03692401606377258 8.758068948702604e-05 / 3.0310746014375745e-05 / 1.8526402456030966e-05 0.013426 3 5 CATSPER1_1 0.0000542935 4.909220079323596e-06 / 0.00011457004964965411 0.0004960672627266704 / 4.1877269236589585e-05 5.97E-05 2 6 TNIP1_2 0.0000000375 0.001606622034643822 / 2.7862939972941576e-05 0.0015404489011240819 / 5.038713072540372e-05 0.000817 2 7 PTX3_2 0.0000000676 1.211019112884484e-05 / 0.004691088270564708 5.3217448419493556e-05 / 4.863050561584803e-06 0.002352 2 8 ZHX3_1 0.0000014893 0.006509687182728191 / 0.008743794449442545 0.0040675934215217225 / 0.00019098934171098681 0.007627 2 9 SH2D3A_1 0.0000000320 0.00986450275259379 / 0.01796408266328998 7.462758949668892e-07 / 1.1020918776918554e-08 0.013914 2 10 SLC39A13_5 0.0000000002 0.00012981264623764855 / 0.030218992308456684 0.0004149038678616304 / 0.00016053338154515 0.015174 2 11 GJB6_1 0.0000254994 0.0011057846043825926 / 0.04337830840329379 4.1575916269860694e-08 / 1.3980763861975182e-05 0.022242 2 12 PLAU_2 0.0000006538 0.03531794281050409 / 0.02526666710345045 4.043892919121399e-05 / 3.9199708585004496e-05 0.030292 2 13 ATG7_1 0.0000274102 4.909220079323596e-06 0.009126969696896518 4.91E-06 One 14 CACNG4_3 0.0000000067 0.00039102555284760144 0.031972846680865336 0.000391 One 15 GJB2_1 0.0000006418 0.0011057846043825926 2.887574461802551e-08 0.001106 One 16 DOCK4_2 0.0000000000 0.0011991500921208242 0.0022356151864022953 0.001199 One 17 AP1M2_3 0.0000000001 0.0033347052264227745 1.674996902910247e-06 0.003335 One 18 RNF216_1 0.0007334440 0.003910529109685535 0.013334064866138773 0.003911 One 19 IRX2_3 0.0000000213 0.0039795105649417465 0.008040031167638424 0.00398 One 20 CXADR_4 0.0000000000 0.004008851856771511 0.00015472825463944093 0.004009 One 21 NEBL_1 0.0000067597 0.008743794449442545 1.0527193471616602e-05 0.008744 One 22 FXYD3_1 0.0008131704 0.009811440592786477 6.611291968968659e-11 0.009811 One 23 SERPINB5_1 0.0000043595 0.009811440592786477 6.545929986856144e-07 0.009811 One 24 GJB3_1 0.0000000848 0.00986450275259379 1.9745785897164974e-07 0.009865 One 25 GJB5_1 0.0000001095 0.00986450275259379 3.7414591927831155e-08 0.009865 One 26 WNT10A_1 0.0000000002 0.00986450275259379 1.0155161311414058e-06 0.009865 One 27 ACLY_1 0.0000197234 0.01038305959856784 0.0002073002808779262 0.010383 One 28 KRT6A_1 0.0000039996 0.011822174156922029 6.092827819585888e-07 0.011822 One 29 PRADC1_1 0.0000003553 0.01619549339490529 4.216127554465152e-06 0.016195 One 30 TIMP1_1 0.0000442505 0.019824604635656325 0.00012088359791880537 0.019825 One 31 GYLTL1B_2 0.0000000917 0.027132275398936593 1.8977666799314624e-07 0.027132 One 32 PTCHD4_4 0.0003324429 0.04021455535799824 0.0022163934450957286 0.040215 One

Table 10 lists the FRHs associated with lung cancer drugs, and the markers defining lung cancer drugs and FRHs associated with them.

In addition, [Table 11] summarizes the results of calculating the degree of reactivity (P-value) of FRHs shown in [Table 10].

In these tables, FRH was expressed in the form of "FRH name_number of included markers", and "Var_Exp (pval)" means the correlation (Pvlaue) value of each marker on the corresponding gene expression, and "Var_Drug (pval)" Means the correlation (Pvlaue) value of the corresponding marker on the reactivity of the drug, and according to the order of drugs listed in [Table 10], the reactivity correlation value for each drug is divided into the classification factor 『/』 `` Exp_Drug (pval) '', the gene expression has a correlation (Pvlaue) value for drug responsiveness according to the order of drugs listed in [Table 10], and "Ave_VarDrug (pval)" is "Var_Drug ( pval) 』means the average of the calculated values, and『 Rank 』means the number of lung cancer drugs that the FRH significantly affects.

From these reactivity verification results, the lower the Var_Exp (pval), the lower the Var_Drug (pval) and its average value, Ave_VarDrug (pval), the lower the Exp_Drug (pval), the higher the Rank number, the corresponding marker determines drug reactivity It can be judged that the effectiveness is high as a biomarker.

Meanwhile, in FIG. 33, correlation values (P-vlaue) values of lung biologic drugs of major biomarkers among the biomarkers listed in Table 10 are graphically displayed, and in FIG. 34, genes expressed by the main biomarkers And P-vlaue values for lung cancer drugs are plotted.

Reactive biomarkers for lung cancer drugs No. FRH Drug DrugType Var (marker) One POLR3K_5 290_KIN001-260 / 287_KIN001-244 / 308_XL-880 / 261_TL-1-85 / 329_QL-XI-92 / 269_NSC-207895 / 332_XMD15-27 / 1268_XAV 939 / 1495_Olaparib / 260_NG-25 / 265_Tubastatin A / 1011_MBT263 / 1011_MBT263 249_XL-184 / 266_Zibotentan / 273_CUDC-101 / 1021_Axitinib / 277_ABT-869 / 1008_Methotrexate / 272_AR-42 / 271_VNLG / 124 / 288_KIN001-055 / 312_AV-951 / 1375_Temozolomide / 346_THZ-2-102-1 206_Ruxolitinib / 328_SNX-2112 / 91_KIN001-135 / 1017_Olaparib / 300_CX-5461 / 152_CP466722 / 276_CAY10603 / 252_WZ3105 / 257_NPK76-II-72-1 / 1158_XMD11-85h / 226_GSK1070916 / 254_ACSK other / pi3k / rtk / other / rtk / p53 / other / wnt / g_integrity / other / chromatin / apop / other / rtk / other / chromatin / rtk / rtk / DNArep / chromatin / chromatin / other / rtk / DNArep / cell_cyc / erk_mapk / other / other / other / other / g_integrity / other / g_integrity / chromatin / other / mitosis / other / mitosis / rtk 2_217847583_C_T / 2_71424561_G_GT / 2_217847883_G_A / 2_217848003_A_G / 17_81206909_A_C 2 FAM114A1_1 326_GSK690693_3 / 1011_Navitoclax_2 / 252_WZ3105_3 / 1248_Daporinad_3 / 299_OSI-027_2 / 269_NSC-207895_3 / 226_GSK1070916_2 / 330_XMD13-2_3 / 302_PI-103_3 / 257_NP_763 pi3k / apop / other / metabol / tor / p53 / mitosis / other / pi3k / mitosis / other / rtk 2_217847583_C_T 3 AVPI1_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1026_Tanespimycin_2 / 1498_Selumetinib_2 / 1007_Docetaxel_1 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1114_Cetuximab_1 / 1015_CI-1040_2 / 1378_Bleomycin_50e_39_391 erk_mapk / erk_mapk / other / erk_mapk / cytoskeleton / erk_mapk / erk_mapk / egfr / erk_mapk / DNArep / wnt / other 3_157413999_A_C 4 S100A11_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1026_Tanespimycin_2 / 1014_Refametinib_2 / 1377_Afatinib_1 / 172_Embelin_2 / 1060_PD0325901_2 / 207_AS601245_3 / 1114_Cetuximab_1 / 1404 erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / egfr / apop / erk_mapk / jnk_p38 / egfr / DNArep / egfr 11_124145287_C_T 5 TMEM92_2 1026_Tanespimycin_2 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 51_Dasatinib_1 / 159_HG6-64-1_3 / 201_Epothilone B_2 / 1007_Docetaxel_1 / 207_AS601L_Culture other / erk_mapk / erk_mapk / erk_mapk / erk_mapk / abl / erk_mapk / cytoskeleton / cytoskeleton / jnk_p38 / other / cell_cyc 8_1565648_A_G / 9_61104415_C_T 6 ATP6V0B_1 1378_Bleomycin (50uM) _1 / 1372_Trametinib_1 / 1526_Refametinib_3 / 51_Dasatinib_1 / 1007_Docetaxel_1 / 1015_CI-1040_2 / 1498_Selumetinib_2 / 1016_Temsirolimus_1 / 172_Embelin_2 / 59_WZ-1-84_3_1_fati / DNArep / erk_mapk / erk_mapk / abl / cytoskeleton / erk_mapk / erk_mapk / tor / apop / other / egfr / egfr 17_78529723_C_G 7 GBP1_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1007_Docetaxel_1 / 1015_CI-1040_2 / 182_Obatoclax Mesylate_2 / 167_OSU-03012_3 / 1062_Selumetinib_2 / 51_Dasatinib erk_mapk / erk_mapk / erk_mapk / erk_mapk / cytoskeleton / erk_mapk / apop / pi3k / erk_mapk / abl 3_55480738_A_T 8 ERLEC1_1 326_GSK690693_3 / 1011_Navitoclax_2 / 252_WZ3105_3 / 299_OSI-027_2 / 330_XMD13-2_3 / 312_Tivozanib_2 / 302_PI-103_3 / 222_BX-912_3 / 329_QL-XI-92_3 pi3k / apop / other / tor / other / rtk / pi3k / pi3k / rtk 10_52768593_C_G 9 SSH3_1 1372_Trametinib_1 / 1377_Afatinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1114_Cetuximab_1 / 1010_Gefitinib_1 / 1015_CI-1040_2 / 1378_Bleomycin (50uM) _1 erk_mapk / egfr / erk_mapk / erk_mapk / egfr / egfr / egfr / erk_mapk / DNArep 3_7680310_G_A 10 TRIP10_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1026_Tanespimycin_2 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1378_Bleomycin (50uM) _1 / 1054_Palbociclib_2 / 1007_Docetaxel_1 erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / erk_mapk / DNArep / cell_cyc / cytoskeleton 14_20381224_T_G 11 MAN1B1_5 1526_Refametinib_3 / 1014_Refametinib_2 / 1372_Trametinib_1 / 1015_CI-1040_2 / 1114_Cetuximab_1 / 1498_Selumetinib_2 / 1060_PD0325901_2 / 1026_Tanespimycin_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk / other 19_57490144_T_A / 19_57473550_A_G / 19_57507480_A_G / 19_57455681_G_T / 19_57455765_G_A 12 CD151_2 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 172_Embelin_2 / 1060_PD0325901_2 / 1026_Tanespimycin_2 / 182_Obatoclax Mesylate_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / apop / erk_mapk / other / apop 3_3845235_C_T / 3_3845163_G_C 13 PDLIM7_1 1007_Docetaxel_1 / 159_HG6-64-1_3 / 1026_Tanespimycin_2 / 1015_CI-1040_2 / 1372_Trametinib_1 / 1054_Palbociclib_2 / 1498_Selumetinib_2 / 1062_Selumetinib_2 cytoskeleton / erk_mapk / other / erk_mapk / erk_mapk / cell_cyc / erk_mapk / erk_mapk 16_84872374_G_C 14 GLIPR1_1 1372_Trametinib_1 / 1007_Docetaxel_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1054_Palbociclib_2 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1026_Tanespimycin_2 erk_mapk / cytoskeleton / erk_mapk / erk_mapk / cell_cyc / erk_mapk / erk_mapk / other 16_55398_G_T 15 GPR87_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1377_Afatinib_1 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1032_Afatinib_1 / 1378_Bleomycin (50uM) _1 erk_mapk / erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk / egfr / DNArep 19_15807367_G_T 16 SNAP25_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1377_Afatinib_1 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1032_Afatinib_1 / 1007_Docetaxel_1 erk_mapk / erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk / egfr / cytoskeleton 2_71424561_G_GT 17 FGFBP1_2 1372_Trametinib_1 / 1377_Afatinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1010_Gefitinib_1 / 1015_CI-1040_2 erk_mapk / egfr / erk_mapk / erk_mapk / egfr / egfr / erk_mapk 2_65069680_A_C / 17_81206909_A_C 18 CHN1_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1377_Afatinib_1 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1015_CI-1040_2 / 1010_Gefitinib_1 erk_mapk / erk_mapk / egfr / erk_mapk / egfr / erk_mapk / egfr 17_81206909_A_C 19 ACSF2_4 1372_Trametinib_1 / 1526_Refametinib_3 / 1114_Cetuximab_1 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1377_Afatinib_1 / 1026_Tanespimycin_2 erk_mapk / erk_mapk / egfr / erk_mapk / egfr / egfr / other 2_71424561_G_GT / 2_71433365_T_TC / 2_71393433_A_G / 2_71428456_T_A 20 SNAPC3_1 1372_Trametinib_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 1060_PD0325901_2 / 1007_Docetaxel_1 erk_mapk / other / erk_mapk / erk_mapk / erk_mapk / erk_mapk / cytoskeleton 15_71256598_T_C 21 ZFP82_1 1377_Afatinib_1 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1114_Cetuximab_1 / 1526_Refametinib_3 / 1032_Afatinib_1 / 1010_Gefitinib_1 egfr / erk_mapk / erk_mapk / egfr / erk_mapk / egfr / egfr 3_33120406_C_T 22 OPHN1_1 1016_Temsirolimus_1 / 1007_Docetaxel_1 / 1372_Trametinib_1 / 1054_Palbociclib_2 / 1526_Refametinib_3 / 1019_Bosutinib_1 / 1026_Tanespimycin_2 tor / cytoskeleton / erk_mapk / cell_cyc / erk_mapk / abl / other 12_54002598_T_G 23 TNS3_1 1014_Refametinib_2 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1060_PD0325901_2 / 1026_Tanespimycin_2 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / other / erk_mapk 7_47967711_A_T 24 P2RY6_5 1372_Trametinib_1 / 1526_Refametinib_3 / 1377_Afatinib_1 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1014_Refametinib_2 erk_mapk / erk_mapk / egfr / erk_mapk / egfr / erk_mapk 2_71424561_G_GT / 2_71399439_CTA_C / 2_71398637_G_A / 2_71393433_A_G / 2_71428456_T_A 25 SCO2_3 1026_Tanespimycin_2 / 1372_Trametinib_1 / 1007_Docetaxel_1 / 1526_Refametinib_3 / 1170_CCT-018159_3 / 1014_Refametinib_2 other / erk_mapk / cytoskeleton / erk_mapk / other / erk_mapk X_14581235_C_G / X_14581237_T_G / X_55487442_C_G 26 KHSRP_1 302_PI-103_3 / 299_OSI-027_2 / 252_WZ3105_3 / 301_PHA-793887_3 / 330_XMD13-2_3 / 1248_Daporinad_3 pi3k / tor / other / cell_cyc / other / metabol 4_119158232_G_A 27 TTC3_1 1007_Docetaxel_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1114_Cetuximab_1 cytoskeleton / other / erk_mapk / erk_mapk / erk_mapk / egfr 12_66128870_G_A 28 STEAP1_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1026_Tanespimycin_2 / 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / erk_mapk 17_50677651_A_G 29 RNF207_2 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1015_CI-1040_2 / 1026_Tanespimycin_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / other 9_134036501_T_G / 16_68564104_A_G 30 C16orf59_2 257_NPK76-II-72-1_3 / 1248_Daporinad_3 / 269_NSC-207895_3 / 265_Tubastatin A_3 / 275_I-BET-762_3 mitosis / metabol / p53 / chromatin / chromatin 2_217847583_C_T / 2_217847883_G_A 31 ICAM1_1 1372_Trametinib_1 / 1498_Selumetinib_2 / 1377_Afatinib_1 / 1526_Refametinib_3 / 159_HG6-64-1_3 erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk 8_12358868_A_G 32 POLE_1 1011_Navitoclax_2 / 269_NSC-207895_3 / 193_GW-2580_3 / 1012_Vorinostat_1 / 1248_Daporinad_3 apop / p53 / rtk / chromatin / metabol 2_217847583_C_T 33 MYT1_3 1011_Navitoclax_2 / 1248_Daporinad_3 / 269_NSC-207895_3 / 211_TL-2-105_3 / 326_GSK690693_3 apop / metabol / p53 / erk_mapk / pi3k 2_217847583_C_T / 2_217848003_A_G / 2_217847883_G_A 34 MMRN2_1 1377_Afatinib_1 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1114_Cetuximab_1 / 1498_Selumetinib_2 egfr / erk_mapk / erk_mapk / egfr / erk_mapk 19_15807367_G_T 35 ZNF420_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1007_Docetaxel_1 erk_mapk / erk_mapk / erk_mapk / erk_mapk / cytoskeleton 6_53654807_C_T 36 ELOVL1_2 1372_Trametinib_1 / 1526_Refametinib_3 / 1026_Tanespimycin_2 / 1498_Selumetinib_2 / 1014_Refametinib_2 erk_mapk / erk_mapk / other / erk_mapk / erk_mapk 1_203683316_A_G / 1_203698281_T_C 37 CHGB_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 51_Dasatinib_1 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk / abl / erk_mapk 15_67236036_T_G 38 MLKL_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1026_Tanespimycin_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / other 17_80137479_A_T 39 FEZ2_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1007_Docetaxel_1 / 1239_YK-4-279_3 / 1060_PD0325901_2 erk_mapk / erk_mapk / cytoskeleton / other / erk_mapk X_108735142_T_G 40 ADNP2_1 1026_Tanespimycin_2 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1372_Trametinib_1 other / erk_mapk / erk_mapk / erk_mapk 9_41294004_C_A 41 CES2_1 1498_Selumetinib_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1010_Gefitinib_1 erk_mapk / erk_mapk / erk_mapk / egfr 8_17085328_C_T 42 DDR1_2 1377_Afatinib_1 / 1010_Gefitinib_1 / 1032_Afatinib_1 / 1372_Trametinib_1 egfr / egfr / egfr / erk_mapk 2_174801578_A_G / 4_89936328_G_A 43 PTGR1_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1026_Tanespimycin_2 / 1014_Refametinib_2 erk_mapk / erk_mapk / other / erk_mapk 19_45698914_C_T 44 LIN7A_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 13_45541596_C_A 45 SYNCRIP_1 257_NPK76-II-72-1_3 / 330_XMD13-2_3 / 301_PHA-793887_3 / 222_BX-912_3 mitosis / other / cell_cyc / pi3k 4_87340676_A_C 46 EREG_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 17_50677651_A_G 47 C12orf57_1 1007_Docetaxel_1 / 1114_Cetuximab_1 / 1372_Trametinib_1 / 204_Tipifarnib_2 cytoskeleton / egfr / erk_mapk / other 1_103082763_C_G 48 PARP9_1 1377_Afatinib_1 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 egfr / erk_mapk / erk_mapk / erk_mapk 4_185267219_TA_T 49 SLITRK3_1 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1526_Refametinib_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk 8_378251_A_G 50 BIRC7_2 1372_Trametinib_1 / 1066_AZD6482_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / pi3k / erk_mapk / erk_mapk 17_78510525_G_A / 17_78507511_T_C 51 ID4_1 173_FH535_3 / 1526_Refametinib_3 / 182_Obatoclax Mesylate_2 / 1372_Trametinib_1 other / erk_mapk / apop / erk_mapk 4_9334816_T_C 52 NUCB2_1 1142_HG-5-113-01_2 / 1054_Palbociclib_2 / 182_Obatoclax Mesylate_2 / 1239_YK-4-279_3 abl / cell_cyc / apop / other 8_26370124_A_G 53 PDLIM1_2 1377_Afatinib_1 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1010_Gefitinib_1 egfr / erk_mapk / erk_mapk / egfr 11_124186080_G_A / 11_124224942_C_A 54 RNF219_3 1011_Navitoclax_2 / 269_NSC-207895_3 / 230_GSK429286A_3 / 226_GSK1070916_2 apop / p53 / cytoskeleton / mitosis 10_31363289_T_C / 2_68528704_T_C / 16_60358945_T_C 55 CTRB2_1 1378_Bleomycin (50uM) _1 / 1242_ (5Z) -7-Oxozeaenol_3 / 1372_Trametinib_1 / 1526_Refametinib_3 DNArep / other / erk_mapk / erk_mapk 4_37433902_C_T 56 RAB31_2 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk X_81277112_A_C / 6_32027037_A_C 57 INADL_2 1010_Gefitinib_1 / 1377_Afatinib_1 / 1032_Afatinib_1 egfr / egfr / egfr 3_58285236_T_C / 2_241246976_C_T 58 DPYSL4_5 1011_Navitoclax_2 / 269_NSC-207895_3 / 275_I-BET-762_3 apop / p53 / chromatin 2_217847583_C_T / 2_217848003_A_G / 2_217847883_G_A / 2_217847379_A_G / 2_217842134_T_C 59 TMEM71_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk 8_12358868_A_G 60 TPD52L2_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk 9_134036501_T_G 61 PDIA3_2 269_NSC-207895_3 / 1011_Navitoclax_2 / 193_GW-2580_3 p53 / apop / rtk 10_52768593_C_G / 15_19964850_A_G 62 KCNK6_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk 17_81206909_A_C 63 CASP8AP2_2 1011_Navitoclax_2 / 326_GSK690693_3 / 269_NSC-207895_3 apop / pi3k / p53 6_109431362_C_A / 10_24584658_G_C 64 LIG1_2 1011_Navitoclax_2 / 269_NSC-207895_3 / 193_GW-2580_3 apop / p53 / rtk 2_217847583_C_T / 2_217848003_A_G 65 ARVCF_1 1526_Refametinib_3 / 1372_Trametinib_1 / 172_Embelin_2 erk_mapk / erk_mapk / apop 15_71256598_T_C 66 PPP1R13L_1 1011_Navitoclax_2 / 211_TL-2-105_3 / 254_Quizartinib_2 apop / erk_mapk / rtk 7_33099535_G_A 67 ELL2_1 1011_Navitoclax_2 / 1248_Daporinad_3 / 269_NSC-207895_3 apop / metabol / p53 6_32183680_C_G 68 TMEM74_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1378_Bleomycin (50uM) _1 erk_mapk / erk_mapk / DNArep 15_67236036_T_G 69 SH3KBP1_1 207_AS601245_3 / 172_Embelin_2 / 204_Tipifarnib_2 jnk_p38 / apop / other 8_12358868_A_G 70 AGXT2L2_4 1011_Navitoclax_2 / 193_GW-2580_3 / 269_NSC-207895_3 apop / rtk / p53 2_217847583_C_T / 2_217848003_A_G / 2_217847883_G_A / 2_217848559_G_A 71 FLNA_1 159_HG6-64-1_3 / 153_Midostaurin_2 / 51_Dasatinib_1 erk_mapk / rtk / abl 3_118902653_C_T 72 EVPL_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1377_Afatinib_1 erk_mapk / erk_mapk / egfr 15_84798628_G_A 73 ITPRIPL1_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk 2_24209270_T_C 74 MFSD5_3 1372_Trametinib_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3 erk_mapk / other / erk_mapk 10_96386941_T_G / 10_93374837_C_T / 12_9153310_A_C 75 IL31RA_1 180_Thapsigargin_3 / 1372_Trametinib_1 / 159_HG6-64-1_3 other / erk_mapk / erk_mapk 4_20727343_G_C 76 PTP4A3_1 1007_Docetaxel_1 / 1372_Trametinib_1 / 1526_Refametinib_3 cytoskeleton / erk_mapk / erk_mapk X_92201459_T_G 77 MMP14_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk 15_99729430_G_C 78 CAND2_3 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk X_101102428_CT_C / X_101102205_C_G / X_101102212_T_C 79 ZNF292_5 1026_Tanespimycin_2 / 1372_Trametinib_1 / 1526_Refametinib_3 other / erk_mapk / erk_mapk 6_32027037_A_C / 12_130357070_A_C / 20_1445690_A_C / X_116441009_T_G / 5_40853381_T_G 80 EPSTI1_1 167_OSU-03012_3 / 1526_Refametinib_3 / 182_Obatoclax Mesylate_2 pi3k / erk_mapk / apop 2_226796327_T_C 81 CD97_5 1026_Tanespimycin_2 / 1372_Trametinib_1 / 1526_Refametinib_3 other / erk_mapk / erk_mapk 7_108514148_A_C / 12_108517007_T_G / 17_80137479_A_T / 5_141193109_A_G / 4_8036186_A_G 82 POLE4_5 1026_Tanespimycin_2 / 1526_Refametinib_3 / 1007_Docetaxel_1 other / erk_mapk / cytoskeleton 2_218618671_A_C / 16_72107293_C_G / 11_47315255_C_G / 21_46116692_T_G / 1_220001162_G_T 83 ZDHHC5_2 1372_Trametinib_1 / 1498_Selumetinib_2 / 1526_Refametinib_3 erk_mapk / erk_mapk / erk_mapk 7_101136942_T_G / 16_89729370_A_C 84 CAV1_1 1011_Navitoclax_2 / 211_TL-2-105_3 / 193_GW-2580_3 apop / erk_mapk / rtk 10_133626829_C_T 85 PRDM15_1 1114_Cetuximab_1 / 1372_Trametinib_1 / 1526_Refametinib_3 egfr / erk_mapk / erk_mapk 5_181333681_C_T 86 TXNL4A_1 1372_Trametinib_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3 erk_mapk / other / erk_mapk 11_124397016_A_G 87 PITX1_1 1268_XAV939_3 / 1372_Trametinib_1 / 1526_Refametinib_3 wnt / erk_mapk / erk_mapk 10_43373649_C_A 88 CDCA5_1 1011_Navitoclax_2 / 269_NSC-207895_3 apop / p53 2_217847583_C_T 89 S100A8_1 1377_Afatinib_1 / 1527_Pictilisib_2 egfr / pi3k 19_7746529_A_C 90 ZNF345_2 207_AS601245_3 / 1007_Docetaxel_1 jnk_p38 / cytoskeleton 6_53654807_C_T / 1_153772281_T_G 91 CXXC1_2 51_Dasatinib_1 / 1372_Trametinib_1 abl / erk_mapk 3_112199369_A_G / 2_119254595_G_A 92 ANO4_1 1526_Refametinib_3 / 1372_Trametinib_1 erk_mapk / erk_mapk 9_41294004_C_A 93 STAG2_1 1526_Refametinib_3 / 1372_Trametinib_1 erk_mapk / erk_mapk 3_10819431_A_G 94 PBX4_1 1011_Navitoclax_2 / 269_NSC-207895_3 apop / p53 1_101786406_G_A 95 RRM1_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 2_217847583_C_T 96 NUPL1_2 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 19_11666277_T_C / 10_31363289_T_C 97 MCFD2_2 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 1_161518073_C_T / 1_161518227_T_C 98 IKBKAP_1 1011_Navitoclax_2 / 269_NSC-207895_3 apop / p53 10_52768593_C_G 99 KHK_2 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 2_217847583_C_T / 2_217848003_A_G 100 SEMA4B_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 7_92469651_G_A 101 CEP41_1 1526_Refametinib_3 / 1372_Trametinib_1 erk_mapk / erk_mapk 13_36365551_C_T 102 DTX3L_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 4_185267219_TA_T 103 SMC2_1 1011_Navitoclax_2 / 269_NSC-207895_3 apop / p53 15_62657955_G_C 104 HDAC6_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 13_45503246_G_A 105 KDM3A_1 1060_PD0325901_2 / 207_AS601245_3 erk_mapk / jnk_p38 9_61211264_T_G 106 DCAKD_1 1011_Navitoclax_2 / 1248_Daporinad_3 apop / metabol 6_32183680_C_G 107 DUSP5_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 6_32183680_C_G 108 PRPF40A_2 301_PHA-793887_3 / 252_WZ3105_3 cell_cyc / other 4_189953012_G_A / 2_237772072_T_G 109 PPIB_4 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 15_59207979_A_G / 15_59207981_C_G / 15_59207987_T_C / 15_59207967_A_G 110 ERAP2_2 1372_Trametinib_1 / 1026_Tanespimycin_2 erk_mapk / other 5_96986715_C_T / 5_96917400_T_C 111 BAALC_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 15_67236036_T_G 112 CACNA2D2_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 15_67236036_T_G 113 CNPY4_1 1377_Afatinib_1 / 288_WHI-P97_3 egfr / other 17_48728228_G_A 114 ANO5_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 12_9427796_G_T 115 KLK6_2 1372_Trametinib_1 / 288_WHI-P97_3 erk_mapk / other 4_48170249_G_A / 4_48170201_C_T 116 TNIP2_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 7_33099535_G_A 117 KCNJ11_4 1011_Navitoclax_2 / 293_Amuvatinib_2 apop / rtk 2_217847583_C_T / 2_217847883_G_A / 2_217848559_G_A / 2_217848003_A_G 118 MED14_1 193_GW-2580_3 / 269_NSC-207895_3 rtk / p53 2_95859911_C_T 119 PDGFC_3 1026_Tanespimycin_2 / 1016_Temsirolimus_1 other / tor 5_150896225_C_T / 5_150898617_C_T / 5_150903222_T_C 120 SLFN12_2 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 1_241723452_T_C / 1_241723462_A_G 121 PDP1_5 1372_Trametinib_1 / 1377_Afatinib_1 erk_mapk / egfr 15_25189495_C_T / 15_25194819_G_A / 15_25199636_G_A / 4_87811722_A_G / 15_25185507_G_A 122 IER5L_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 9_34623341_A_G 123 ABCA5_2 1372_Trametinib_1 / 1026_Tanespimycin_2 erk_mapk / other 17_50677651_A_G / 17_78529677_G_C 124 CABP7_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 1_46344858_A_G 125 FCRLB_5 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 2_118982373_A_G / 17_81276033_A_C / X_132085721_T_C / 15_82463815_A_C / 9_41189241_T_C 126 TIGD3_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 5_135888024_G_T 127 ZNF295_1 159_HG6-64-1_3 / 1526_Refametinib_3 erk_mapk / erk_mapk 11_113854221_T_C 128 PLD2_1 1114_Cetuximab_1 / 288_WHI-P97_3 egfr / other 15_84407910_G_A 129 CD55_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 5_113384951_C_A 130 QKI_3 1242_ (5Z) -7-Oxozeaenol_3 / 1007_Docetaxel_1 other / cytoskeleton 6_87514446_T_C / 6_87612279_G_A / 6_87511385_T_C 131 MZT1_1 1011_Navitoclax_2 / 269_NSC-207895_3 apop / p53 10_31363289_T_C 132 SEMA7A_1 1372_Trametinib_1 / 182_Obatoclax Mesylate_2 erk_mapk / apop 22_24253656_C_G 133 ROR2_1 1372_Trametinib_1 / 1377_Afatinib_1 erk_mapk / egfr 13_44436731_C_T 134 TRIP6_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 17_78529677_G_C 135 C14orf142_1 1242_ (5Z) -7-Oxozeaenol_3 / 1378_Bleomycin (50uM) _1 other / DNArep 11_66055499_T_G 136 ZEB1_2 1377_Afatinib_1 / 1032_Afatinib_1 egfr / egfr 3_58285236_T_C / 9_41905830_C_G 137 NIP7_2 344_THZ-2-49_3 / 1007_Docetaxel_1 cell_cyc / cytoskeleton 9_33529025_G_T / 9_122724363_T_G 138 GNAO1_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 10_133626013_G_A 139 FGF9_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 13_32131648_A_G 140 SERINC3_1 1114_Cetuximab_1 / 1526_Refametinib_3 egfr / erk_mapk 2_25980839_T_G 141 RSBN1_1 1026_Tanespimycin_2 / 1372_Trametinib_1 other / erk_mapk 2_127286836_G_C 142 ARVCF_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 10_133626829_C_T 143 DTL_1 269_NSC-207895_3 / 326_GSK690693_3 p53 / pi3k 2_29239654_G_A 144 SRSF7_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 5_181333681_C_T 145 IFIT5_2 1526_Refametinib_3 / 1372_Trametinib_1 erk_mapk / erk_mapk 6_169632990_G_A / 6_169665646_G_A 146 NARF_1 1007_Docetaxel_1 / 1526_Refametinib_3 cytoskeleton / erk_mapk 12_32328439_A_C 147 CASP8_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 17_75904383_G_C 148 IL17RB_1 1239_YK-4-279_3 / 1526_Refametinib_3 other / erk_mapk 19_44506064_G_T 149 SLC15A2_1 1377_Afatinib_1 egfr 2_174801578_A_G 150 SAR1B_1 193_GW-2580_3 rtk 5_155013898_A_G 151 TTC1_1 1011_Navitoclax_2 apop 5_155013898_A_G 152 CRP_2 165_DMOG_3 other 9_129834783_A_C / 17_69536247_A_G 153 GGCX_1 1011_Navitoclax_2 apop 19_39875355_A_T 154 SOX9_1 1066_AZD6482_2 pi3k 11_1092981_A_C 155 DLX5_3 1011_Navitoclax_2 apop 2_217847883_G_A / 2_217848003_A_G / 2_217847583_C_T 156 SNRNP25_3 1011_Navitoclax_2 apop 2_217847883_G_A / 2_217847583_C_T / 2_217848003_A_G 157 UHRF1BP1L_1 29_AZ628_3 erk_mapk 2_113594958_C_G 158 PAPD4_1 1011_Navitoclax_2 apop 19_54274840_G_A 159 ADAMTS14_1 1011_Navitoclax_2 apop 19_52554226_G_A 160 FAT2_1 1377_Afatinib_1 egfr 19_15807367_G_T 161 ZNF750_2 1377_Afatinib_1 egfr 19_15807367_G_T / 19_15794719_C_A 162 BTG2_1 1026_Tanespimycin_2 other 6_34872273_T_G 163 PIGB_4 1011_Navitoclax_2 apop 15_59207979_A_G / 15_59207981_C_G / 15_59207987_T_C / 15_59207967_A_G 164 WHAMM_4 1011_Navitoclax_2 apop 15_59207967_A_G / 15_59207979_A_G / 15_59207981_C_G / 15_59207987_T_C 165 PELI2_2 1011_Navitoclax_2 apop 9_114169457_C_T / 17_68420216_C_T 166 RPS5_1 302_PI-103_3 pi3k 10_89339873_T_C 167 DALRD3_1 1011_Navitoclax_2 apop 1_244857989_TA_T 168 ANKRD22_1 1372_Trametinib_1 erk_mapk 17_81206909_A_C 169 AGBL4_5 1011_Navitoclax_2 apop 2_217847883_G_A / 2_217848003_A_G / 2_217847583_C_T / 2_217842134_T_C / 2_217847379_A_G 170 DCUN1D2_1 1011_Navitoclax_2 apop 10_31363289_T_C 171 RAP2A_1 1011_Navitoclax_2 apop 10_31363289_T_C 172 TEX30_1 1011_Navitoclax_2 apop 10_31363289_T_C 173 CPNE8_1 1011_Navitoclax_2 apop X_24055660_C_A 174 IFIT3_1 1011_Navitoclax_2 apop 18_50806833_C_G 175 KCNMB2_1 1011_Navitoclax_2 apop 18_50806833_C_G 176 TRIM21_1 1011_Navitoclax_2 apop 18_50806833_C_G 177 NAP1L4_1 1011_Navitoclax_2 apop 12_27969552_T_A 178 GALNT3_1 1377_Afatinib_1 egfr 3_7680310_G_A 179 EVL_1 1011_Navitoclax_2 apop 7_33264495_A_G 180 TSPAN8_1 1242_ (5Z) -7-Oxozeaenol_3 other 14_59565278_G_A 181 RUNDC3B_1 1011_Navitoclax_2 apop 4_68236279_G_GA 182 CCDC113_1 1054_Palbociclib_2 cell_cyc 16_67199408_A_C 183 PIAS2_2 1526_Refametinib_3 erk_mapk 18_49837560_A_G / 18_49837561_G_C 184 ALG14_1 1023_GW441756_3 rtk 12_27755086_G_GA 185 TAF11_1 1011_Navitoclax_2 apop 15_84516674_T_G 186 KCNK9_1 193_GW-2580_3 rtk 10_28880454_A_G 187 LRRC8A_1 1377_Afatinib_1 egfr 5_173158713_A_G 188 TMEM151B_1 1372_Trametinib_1 erk_mapk 9_67920363_C_T 189 C10orf76_1 1007_Docetaxel_1 cytoskeleton 2_169557387_G_GA 190 NXNL2_1 1007_Docetaxel_1 cytoskeleton 12_54002598_T_G 191 TCEB3_1 330_XMD13-2_3 other 14_67333008_A_G 192 CPEB2_2 266_Zibotentan_2 other 8_22102127_A_G / 8_22102128_C_T 193 TUBB_1 193_GW-2580_3 rtk 1_101786406_G_A 194 UBE2H_1 1011_Navitoclax_2 apop 2_9279286_C_T 195 TM9SF4_1 1526_Refametinib_3 erk_mapk 9_41294004_C_A 196 ZNF250_1 1011_Navitoclax_2 apop 5_135888024_G_T 197 ARSD_1 269_NSC-207895_3 p53 1_101786406_G_A 198 ZBED5_5 1026_Tanespimycin_2 other 5_176529597_A_C / 14_69704655_C_T / 11_62807431_T_G / 7_99486962_A_C / 5_138430313_A_C 199 TEAD3_3 1011_Navitoclax_2 apop 18_166710_TTAAAA_T / 18_166819_T_C / 18_264012_G_A 200 PAICS_1 1377_Afatinib_1 egfr 19_50637249_G_A 201 SDSL_1 1026_Tanespimycin_2 other 3_31664157_C_T 202 SP140L_1 1011_Navitoclax_2 apop 19_9857463_G_A 203 VEZF1_1 1011_Navitoclax_2 apop 4_122258745_C_T 204 TSR2_2 1011_Navitoclax_2 apop 8_109271027_T_C / 8_109271124_T_G 205 LRFN5_1 1011_Navitoclax_2 apop 10_3165440_A_G 206 HMOX1_3 1026_Tanespimycin_2 other 1_183239405_G_A / 20_39018962_A_C / 2_86785910_T_G 207 OAF_2 1011_Navitoclax_2 apop 9_83978162_A_T / 9_83976942_T_C 208 C1orf198_1 193_GW-2580_3 rtk 20_6215106_T_C 209 RNF145_1 193_GW-2580_3 rtk 15_65447029_G_A 210 TFDP1_2 1011_Navitoclax_2 apop 10_31363289_T_C / 16_60358945_T_C 211 TRIM33_5 1026_Tanespimycin_2 other 5_176575310_A_C / 6_136362716_T_G / 4_78315728_T_G / 22_42516026_A_G / 12_14806481_T_G 212 BRD1_1 147_NSC-87877_3 other 5_154002958_G_A 213 RAB18_1 1011_Navitoclax_2 apop 3_146194512_C_T 214 DOK6_1 1011_Navitoclax_2 apop 18_12840880_T_C 215 TMEM132D_1 1011_Navitoclax_2 apop 1_89592683_G_GT 216 RBKS_1 1011_Navitoclax_2 apop 7_140126550_T_A 217 SDPR_1 1372_Trametinib_1 erk_mapk 15_23364667_T_G 218 HADHB_3 1011_Navitoclax_2 apop 19_48944320_G_A / 19_48944456_G_A / 19_48942517_C_T 219 RAB2B_1 1011_Navitoclax_2 apop 15_20251568_G_A 220 CLSPN_2 1011_Navitoclax_2 apop 15_62651935_A_G / 15_62657955_G_C 221 LRCH2_1 1372_Trametinib_1 erk_mapk 19_1825787_T_TA 222 RIC8B_1 1011_Navitoclax_2 apop 3_39412024_A_G 223 SNX17_1 1026_Tanespimycin_2 other 17_43879789_T_G 224 HPS1_3 1026_Tanespimycin_2 other 9_136463607_G_A / 9_136476782_G_A / 9_136453326_A_G 225 TNNT3_1 1377_Afatinib_1 egfr 2_226796327_T_C 226 MPHOSPH9_1 257_NPK76-II-72-1_3 mitosis 14_104949986_T_C 227 PCDH7_1 1372_Trametinib_1 erk_mapk 11_64284449_A_C 228 NSL1_1 193_GW-2580_3 rtk 3_75665457_C_T 229 ALG9_1 1011_Navitoclax_2 apop 14_76498312_C_T 230 PDE12_1 1006_Cytarabine_1 DNArep 1_161518073_C_T 231 PAPSS2_1 173_FH535_3 other 1_485270_G_A 232 ZFHX2_1 1011_Navitoclax_2 apop 9_27567147_C_T 233 TFG_2 1011_Navitoclax_2 apop X_16150554_T_C / X_16150344_T_C 234 IL15RA_1 1011_Navitoclax_2 apop 22_36566306_C_G 235 MBTD1_1 1248_Daporinad_3 metabol 22_36566306_C_G 236 TMPRSS4_1 1372_Trametinib_1 erk_mapk 11_18484085_G_A 237 APBB1_1 1011_Navitoclax_2 apop 7_117548606_ATG_A 238 MAD2L2_1 1011_Navitoclax_2 apop 7_117548606_ATG_A 239 MAP4_1 1011_Navitoclax_2 apop 7_33099535_G_A 240 GLTP_1 1377_Afatinib_1 egfr 2_182994745_T_C 241 CECR2_1 1011_Navitoclax_2 apop 15_30596563_A_G 242 RUFY1_1 1011_Navitoclax_2 apop 17_73212821_T_C 243 LRRN1_3 1372_Trametinib_1 erk_mapk 10_26492426_T_C / 4_654142_G_A / 14_67347493_A_C 244 ATRIP_1 1026_Tanespimycin_2 other 19_815835_G_A 245 NADKD1_1 1011_Navitoclax_2 apop 3_16323447_C_T 246 DAPL1_5 1026_Tanespimycin_2 other 15_78923063_A_C / 1_2588455_T_G / 20_32797074_C_A / 14_69704655_C_T / 17_7701545_A_C 247 HSD17B10_1 1011_Navitoclax_2 apop 5_24511259_C_T 248 CTSL1_5 1526_Refametinib_3 erk_mapk 7_6857531_A_G / 10_62069760_A_C / 17_80137479_A_T / X_52907336_A_C / 3_62493670_T_G 249 PPM1F_2 1031_Elesclomol_2 other 14_72893955_C_G / 16_29382935_T_G 250 SERPINB8_1 1248_Daporinad_3 metabol 6_69361281_G_A 251 LEPREL4_1 1011_Navitoclax_2 apop 19_11116804_A_C 252 HIRA_1 225_Genentech Cpd 10_3 mitosis 9_41341340_C_T 253 MET_2 1011_Navitoclax_2 apop 10_133626013_G_A / 10_133626012_T_A 254 ST18_2 1011_Navitoclax_2 apop 10_133626012_T_A / 10_133626013_G_A 255 IFI35_1 1372_Trametinib_1 erk_mapk 12_15589379_GA_G 256 CNKSR3_1 1166_QL-VIII-58_3 tor 17_78539866_T_C 257 NFKBIZ_1 1372_Trametinib_1 erk_mapk 6_47579334_T_TAA 258 TFPI_1 1372_Trametinib_1 erk_mapk 6_47579334_T_TAA 259 PDIA6_1 1011_Navitoclax_2 apop 11_17498150_C_G 260 RSF1_3 1026_Tanespimycin_2 other 8_143870873_T_G / 1_54986510_A_C / 12_14806481_T_G 261 MYO1E_2 1372_Trametinib_1 erk_mapk 15_25170856_G_A / X_153670877_G_T 262 UBAP1_1 1372_Trametinib_1 erk_mapk 5_31510999_G_T 263 GFER_1 1026_Tanespimycin_2 other 2_85639407_A_C 264 C17orf75_1 211_TL-2-105_3 erk_mapk 6_32183680_C_G 265 TTC9B_1 1011_Navitoclax_2 apop 17_74541739_G_A 266 FAM198B_1 211_TL-2-105_3 erk_mapk 6_106519310_A_C 267 DCTD_1 1026_Tanespimycin_2 other 8_7429219_C_T 268 ZSCAN16_1 1011_Navitoclax_2 apop 7_26185482_G_A 269 CCDC14_2 1372_Trametinib_1 erk_mapk 7_33357933_C_A / 9_33529025_G_T 270 TRIP11_1 1011_Navitoclax_2 apop 1_230792766_C_G 271 NKAIN2_1 1011_Navitoclax_2 apop 1_169804019_T_C 272 NT5E_1 1011_Navitoclax_2 apop 1_169804019_T_C 273 PPP1R14A_5 196_Phenformin_3 metabol 15_57438247_A_C / 5_76209739_T_G / X_149774713_G_C / 1_35479062_T_G / 9_109406442_T_C 274 CDH2_1 1241_CHIR-99021_3 wnt 1_155060858_G_A 275 EMC3_1 151_QS11_3 other 1_197039467_A_C 276 NCAPG2_1 6_PHA-665752_3 rtk 1_149021276_A_C 277 OR13H1_2 166_FTI-277_3 other 2_201728736_A_G / 2_201723527_C_T

Results of verification of biomarker responsiveness to lung cancer drugs No. FRH Var_Exp (pval) Var_Drug (pval) Exp_Drug (pval) Ave_VarDrug (pval) Rank One POLR3K_5 1.67E-06 7.55E-05 / 9.21E-05 / 0.000406169 / 0.000572894 / 0.000596706 / 0.000830024 / 0.000897369 / 0.000943017 / 0.00100282 / 0.001405937 / 0.001436612 / 0.001463281 / 0.001585317 / 0.00161475 / 0.001676489 / 0.001964123 / 0.00196632 / 0.002055398 / 0.002082114 / 0.002914256 / 0.002947382 / 0.003272641 / 0.003463499 / 0.00367462 / 0.00367676 / 0.003769026 / 0.003782462 / 0.004059938 / 0.004512707 / 0.005161898 / 0.005787569 / 0.006314892 / 0.006945435 / 0.008072051 / 0.008410403 / 0.008931324 0.001531019 / 0.057569018 / 0.249595562 / 0.085576027 / 0.000387243 / 1.59E-05 / 0.059525284 / 0.863014405 / 0.249659436 / 0.124147024 / 0.000281163 / 7.11E-06 / 0.019500847 / 0.695397999 / 0.001918781 / 0.086727092 / 0.023202587 / 0.000441974 / / 0.036578315 / 0.000474321 / 0.011974306 / 0.079370245 / 0.828009563 / 0.010696272 / 0.005232793 / 0.582545022 / 0.058088741 / 0.00262003 / 0.049789754 / 0.228619231 / 0.001174198 / 7.02E-05 / 1.63E-06 / 0.295541863 / 7.79E-06 / 3.75E-05 2.97E-03 39 2 FAM114A1_1 0.0000025505 0.0042694104092888974 / 0.00020876871631167866 / 0.0007568114081113288 / 0.0035305946391629545 / 0.008363870991709823 / 1.4383640936438872e-05 / 7.009824754153582e-05 / 0.0035938658204617215 / 0.006293754132220173 / 0.0032074496683567847 / 0.0204010340651556 1.985359164220784e-08 / 1.9619211144338805e-07 / 1.1786246361826978e-07 / 1.2984459856816525e-07 / 6.679222855070028e-07 / 7.60276325486698e-06 / 4.381181635105041e-08 / 3.0395531368179466e-06 / 3.92186793718892e-06534 / 2.2310227467645046e-05 / 6.449074536371506e-07 0.004255434 12 3 AVPI1_1 0.0000003933 0.0006396902026437372 / 0.0035535295006568564 / 0.004142441090345042 / 0.008737166819403942 / 0.005365726625203914 / 0.016265715773138612 / 0.041737910661353794 / 0.03071155447434498 / 0.012033224729341468 / 0.013915501344307473 / 0.009991096973902677 / 0.01939906554836552 8.724099353866297e-18 / 4.327010736165959e-17 / 8.775781672799915e-14 / 3.5651532383955547e-13 / 2.396709082503607e-12 / 5.521480171031492e-10 / 1.2559804874872373e-08 / 2.0783114956254993e-07 / 4.311397020221965e-08 / 2.2998188297812e 5.132866263479021e-07 / 2.0389575690868755e-07 0.013874385 12 4 S100A11_1 0.0000007141 0.0002735997430699673 / 0.006564850275482538 / 0.00042414739039363294 / 0.029067524880234556 / 0.0227837453875734 / 0.0013348733587389963 / 0.025661191456139584 / 0.030326580226023813 / 0.01355699403064558 / 0.004313726310163241 / 0.0095400572561103 / 0.04535245314863 6.393329432968863e-16 / 1.2307435361378187e-13 / 2.466858890049804e-13 / 5.545342625838226e-09 / 1.0380326612394311e-08 / 2.3437239888960063e-09 / 1.3417028235666536e-07 / 4.443975040006529e-07 / 9.063384713333984e-07 / 1.1118101978 2.049520010016173e-06 / 4.414454919747786e-06 0.015766646 12 5 TMEM92_2 0.0000000001 8.127905920870596e-06 / 0.03825717382100051 / 0.03457460632857845 / 0.004853137512524773 / 0.03388689864411195 / 0.008814758212945951 / 0.03578088316319923 / 0.006217130934294085 / 0.00017355910676635736 / 0.0280335961707743 / 0.0017388474926662016 / 0.000124608308510 2.4261531255663892e-11 / 5.0311269179717914e-11 / 2.4975316917871734e-10 / 2.042638151066576e-07 / 1.5566664880019958e-10 / 5.680894385767319e-06 / 1.6699000588343938e-06 / 6.566036837900111e-06 / 3.420597261413642e-07 / 8.237906153 9.263610563311242e-07 / 1.2428063696083114e-06 0.016038611 12 6 ATP6V0B_1 0.0000017465 0.00016551876926533193 / 0.015335407229032524 / 0.0076626373197674 / 0.028777417252359768 / 0.026082796942956787 / 0.0389316131443371 / 0.0004915314263603532 / 0.0014839424825817675 / 0.022837697585243923 / 0.01178531426696526 / 0.00988329756179177 / 0.0317276252166644 2.401602140750141e-13 / 4.8650677089433124e-11 / 3.9493836034696935e-10 / 7.33482261725945e-09 / 2.8535418288695915e-08 / 2.096326058421669e-09 / 1.5659535702420375e-08 / 3.964614244828257e-07 / 1.7237698783914587e-07 / 3.2415943673 6.164017172502494e-08 / 3.4316628105398186e-07 0.016263733 12 7 GBP1_1 0.0000405829 0.04015481753439807 / 0.018576825788521975 / 0.01852560134227437 / 0.002373869363376313 / 0.02782754766981264 / 0.002415619395480455 / 0.011881237105466349 / 0.00033563208340305035 / 0.005055991739999371 / 0.008903270762925434 1.187415764241114e-11 / 6.095615889440819e-11 / 1.917288218821707e-12 / 5.619391245841771e-08 / 1.1719944005143196e-08 / 1.0794280052002033e-07 / 5.9596304962709845e-08 / 0.0004931619081689741 / 9.495988028273389e-08 / 1.166692939780 0.013605041 10 8 ERLEC1_1 0.0000005719 3.075536174342061e-06 / 0.012665982332335715 / 2.1913337236976437e-05 / 7.482707136703458e-05 / 2.6075431224558473e-05 / 5.690512097896811e-05 / 0.0020110917770508187 / 0.0009108241993284896 / 9.402887850421925e-06 8.155050086866359e-08 / 8.547376478456365e-07 / 4.650557832871856e-07 / 1.979425060398104e-07 / 9.659100942891217e-07 / 1.5727836576660756e-05 / 2.4902482384647638e-06 / 5.963679135141154e-06 / 0.0002870787007736368 0.001753344 9 9 SSH3_1 0.0000007635 0.0035447981156988204 / 0.0020476470911988563 / 0.0043734414976099745 / 0.00442890244448457 / 0.0016646475834734644 / 0.003469684588834184 / 0.016258281480713958 / 0.007203498668728194 / 0.008481086009715616 1.2839817776716313e-11 / 2.1456295745112202e-09 / 7.804965919854057e-11 / 1.0846113597262452e-10 / 8.402308355591066e-09 / 4.0629325207940226e-07 / 3.407462995284017e-05 / 4.726367578576213e-06 / 2.5541465321521183e-06 0.00571911 9 10 TRIP10_1 0.0000173218 0.008943680317061822 / 0.0013412546793620756 / 0.0015773645986452735 / 0.007477694270383053 / 0.03117319702966703 / 0.03615921936711382 / 0.0031899243253359325 / 0.01485798676987582 / 0.03709204807398679 2.967675338863489e-16 / 1.3369912839925863e-16 / 9.67218561771649e-13 / 1.6290794365229653e-10 / 7.687956044278108e-10 / 4.534964360985728e-09 / 5.405201490429158e-09 / 7.483583479891572e-09 / 6.363635419128828e-06 0.01575693 9 11 MAN1B1_5 0.0000014304 0.0023856498203327875 / 7.812266726494329e-05 / 0.027952944492863622 / 0.005617959119750928 / 0.002644793270745064 / 0.012381465875087235 / 0.0074542403283965625 / 0.001546432706758083 1.868937111544232e-10 / 1.6531442166915098e-08 / 9.414450468098132e-09 / 7.030425208487326e-08 / 4.773344609707843e-08 / 3.1813403816802826e-08 / 1.2054478070790373e-06 / 5.5556733765270095e-06 0.007507701 8 12 CD151_2 0.0000016613 0.002828971924250992 / 0.0020308786555996105 / 0.0037139272628794475 / 0.0008147078915095311 / 0.0027987535750038264 / 0.03156448872153919 / 0.006216893575679977 / 0.012774860953989628 1.3495328256839188e-12 / 1.6512296821172123e-12 / 3.6414648280531383e-13 / 2.006846342245524e-10 / 9.201808809340132e-08 / 5.931180856539697e-07 / 3.000290377999784e-07 / 5.940973440824346e-07 0.007842935 8 13 PDLIM7_1 0.0000151792 0.0017419308016053887 / 0.01703591045996455 / 0.010263742478054323 / 0.0074877120166343125 / 0.003951752871247063 / 0.023461658690951844 / 0.0007060714810871347 / 0.00993017974219656 1.4890466266195927e-09 / 1.3930872632280484e-10 / 4.042121027066677e-08 / 5.515991658674008e-07 / 3.206759648352692e-09 / 7.38168534365637e-08 / 1.2279749259117268e-08 / 1.6868345203620706e-07 0.00932237 8 14 GLIPR1_1 0.0000014611 0.008133825444941598 / 0.0005214752415830771 / 0.01773178574837757 / 0.009430350367584172 / 0.01955380058568292 / 0.003589646250229098 / 0.0015918099299812008 / 0.021268808314233105 1.4019555545362636e-10 / 1.3355121304727163e-10 / 5.96825464847569e-10 / 7.437295967997082e-09 / 2.751586429438836e-09 / 5.123469233147485e-08 / 4.827912592803016e-07 / 9.24174412768079e-06 0.010227688 8 15 GPR87_1 0.0000006448 0.0076251167073391945 / 0.0028222416161458853 / 0.033262979309241485 / 0.0006381430782712855 / 0.0019094505299096247 / 0.018260880298473985 / 0.003923489922251829 / 0.014606068770244599 7.534055709544274e-17 / 2.585655261990035e-15 / 5.2335156402490275e-15 / 2.4905394673635635e-09 / 2.579143491051842e-10 / 3.3024470123206265e-08 / 2.0302747016952384e-07 / 3.115039621495257e-06 0.010381046 8 16 SNAP25_1 0.0000076174 0.0018807133849514282 / 0.0021339409269866432 / 0.008547140700416327 / 0.007837425491160097 / 0.0018204809165742553 / 0.01250093546784304 / 0.029444897497836964 / 0.025484654242891817 1.4208036186314184e-16 / 1.5507536243084707e-13 / 1.696952191969015e-11 / 1.009604302429168e-09 / 1.0410206618966501e-09 / 1.850497353460836e-09 / 1.0634082068029867e-08 / 1.0722107820456968e-07 0.011206274 8 17 FGFBP1_2 0.0000000001 0.00017601864871485512 / 0.0005070210241593581 / 0.004411629733717425 / 0.008689109920315017 / 0.00019506735122442717 / 0.009640097626965513 / 0.006852417553255793 1.9060720081271283e-13 / 3.122850645863472e-09 / 4.1994336271257894e-10 / 6.0155643158720954e-09 / 3.843362175544889e-08 / 8.712480724022447e-06 / 1.9248384673484406e-07 0.004353052 7 18 CHN1_1 0.0000025565 0.0014573918997663137 / 0.008577741421710208 / 0.001198103041045066 / 0.001533522936452515 / 0.0033634941504627697 / 0.010785244262186303 / 0.0373128898832142 6.175453097411747e-15 / 1.0898537184801719e-12 / 4.243100156030503e-12 / 2.3893328777750658e-08 / 3.7113695617625286e-08 / 1.3950404315566743e-06 / 4.353340320251518e-07 0.009175484 7 19 ACSF2_4 0.0000126680 0.002287441661560721 / 0.002739732144211229 / 0.010839213238666172 / 0.02699935544242534 / 0.006587582753649601 / 0.020104758213330888 / 0.0037867420062336647 1.6018264558328353e-11 / 1.350522100376996e-10 / 3.533719025417417e-08 / 9.421341247634894e-07 / 6.358471973834479e-06 / 0.0005708652264651822 / 2.8573976842147612e-05 0.010477832 7 20 SNAPC3_1 0.0000014845 0.003808062774578335 / 0.03330161757206289 / 0.001267397044740127 / 0.025490833026200553 / 0.005752102707973715 / 0.010531169902390105 / 0.02097227539629169 4.138352317586387e-12 / 6.324952413663082e-12 / 2.3039595587795142e-11 / 4.135749382360492e-09 / 2.943942798609411e-09 / 4.785025404402047e-07 / 8.45468021727955e-07 0.014446208 7 21 ZFP82_1 0.0000002911 0.026193133649308403 / 0.002880197932827539 / 0.000892065314189748 / 0.03621760269335816 / 0.001409066709832824 / 0.03632632282612366 / 0.001597966657771602 2.1821058503470977e-07 / 2.1345284484994668e-07 / 1.6940360882868594e-06 / 2.332116712137168e-06 / 7.078139307433867e-06 / 4.932653487474453e-06 / 5.57905665828971e-06 0.015073765 7 22 OPHN1_1 0.0002612099 0.04894666674267963 / 0.003544372498506248 / 0.03445218818410945 / 0.029417648259261447 / 0.01144054174070861 / 0.030599292085887794 / 0.003150128220025032 2.2816161503286945e-09 / 5.483877356966662e-07 / 6.645530643543907e-07 / 1.1508399694576279e-07 / 2.1220867950204813e-06 / 1.0055030736784958e-05 / 8.336038812610863e-05 0.023078691 7 23 TNS3_1 0.0000006277 0.009569659528755218 / 0.0013302955859364471 / 0.0037548210952919408 / 0.0024792131341982242 / 0.003608716025393357 / 0.002638008434399487 8.722976186020636e-08 / 1.7164630812419945e-08 / 1.770632094332526e-08 / 1.9486556735289747e-07 / 4.0623560474101545e-07 / 5.860863385843348e-07 0.003896786 6 24 P2RY6_5 0.0000010436 0.0009804545262469449 / 0.0013446510229950341 / 0.003789065107490644 / 0.006218322225340153 / 0.03645229771138508 / 0.01562975702849699 1.576709465685621e-13 / 2.5331252718662176e-10 / 2.3521007770880894e-07 / 2.3770553645092087e-10 / 1.368096065972398e-07 / 2.5418800842381177e-07 0.010735758 6 25 SCO2_3 0.0000000001 0.01546077257784758 / 0.001964618656338199 / 0.0033965914999294854 / 0.012145502525993949 / 0.030055718710212946 / 0.013950769826858294 8.014599938246778e-09 / 1.8636695061114395e-08 / 3.705794897358954e-08 / 4.2936074352856663e-07 / 5.584053250118188e-05 / 2.397206724754045e-07 0.012828996 6 26 KHSRP_1 0.0000003011 0.010352775099646664 / 0.019182484865138457 / 0.015100022601522628 / 0.01700255170966236 / 0.023101003520372643 / 0.006776149448547382 2.8490498620729386e-09 / 5.206538616416615e-10 / 1.4824605802962609e-08 / 7.704856226971619e-07 / 5.512137468127689e-07 / 3.2143315687611383e-06 0.015252498 6 27 TTC3_1 0.0000002043 0.021976203067763718 / 0.014404186233262522 / 0.010065328958198384 / 0.005185630347493037 / 0.01771094219397329 / 0.026010950792548747 1.903714561147216e-10 / 1.8998104659295357e-09 / 8.134060967771899e-10 / 7.905696358239668e-09 / 1.7016664284191773e-06 / 2.3041895625093597e-07 0.015892207 6 28 STEAP1_1 0.0000029634 0.013036283678806082 / 0.015688398206555057 / 0.006349160970663491 / 0.03777942745740614 / 0.010550376036332488 / 0.017877825906191358 6.761435756061347e-12 / 2.4207465935628376e-11 / 3.564533224675541e-12 / 4.401553310565403e-08 / 1.2935469598692122e-07 / 1.118837878226449e-05 0.016880245 6 29 RNF207_2 0.0000000000 0.010918237443275771 / 0.010043999800272532 / 0.007055519329675997 / 0.027127865042923947 / 0.036896549219609824 / 0.015551929442979676 2.026443768844747e-13 / 1.0452530817759512e-11 / 3.4953412148396826e-12 / 2.417587221451319e-08 / 4.833952724825644e-07 / 6.916720467647325e-07 0.01793235 6 30 C16orf59_2 0.0000011638 0.0017105849166402373 / 0.008006011161483364 / 2.877198249929341e-05 / 0.00044269902702600075 / 0.0035960656357070827 8.710873698386588e-07 / 1.6466535184566052e-06 / 3.1826237601737307e-06 / 1.5852069704631895e-05 / 5.3568783395819636e-05 0.002756827 5 31 ICAM1_1 0.0000008958 0.0006371740222421855 / 0.0004238045362036801 / 0.004627658102704232 / 0.0017187301776334363 / 0.0141342657951169 5.301958232122965e-10 / 5.691310460319534e-10 / 9.501545566679268e-08 / 7.484161653079297e-07 / 1.0741352344507851e-05 0.004308327 5 32 POLE_1 0.0000006233 0.00020876871631167866 / 1.4383640936438872e-05 / 0.010067369603256736 / 0.012703084299864359 / 0.0035305946391629545 4.564149862726603e-11 / 4.031853969284765e-09 / 2.1715096143998947e-09 / 5.185675527716179e-08 / 9.417769469553245e-08 0.00530484 5 33 MYT1_3 0.0000018757 0.0003180382059133217 / 0.008006011161483364 / 2.877198249929341e-05 / 0.022477574071905464 / 0.002087164867003088 1.3185457834679754e-09 / 1.0046430313676016e-07 / 8.61285349137364e-07 / 5.400726736519221e-07 / 1.926503424303301e-05 0.006583512 5 34 MMRN2_1 0.0000020377 0.0006381430782712855 / 0.0028222416161458853 / 0.0076251167073391945 / 0.003923489922251829 / 0.033262979309241485 1.858452443514514e-05 / 1.5622701951466016e-05 / 3.730943185783191e-05 / 0.0001274335060935434 / 0.0007602117674326636 0.009654394 5 35 ZNF420_1 0.0000000763 0.00765254728362311 / 0.02761664002677436 / 0.005704138976540187 / 0.0062144909889472 / 0.02210665467937813 2.2557919455927213e-08 / 3.8434441624955556e-08 / 4.143652073206543e-08 / 8.451473540512692e-07 / 4.161971954576053e-06 0.013858894 5 36 ELOVL1_2 0.0000041883 0.005612639115469282 / 0.004888298105885152 / 0.008969805039998042 / 0.030404112516122277 / 0.03243772518292004 3.522904480656644e-10 / 4.32348036263409e-10 / 1.2293459738289953e-08 / 1.8913948776318332e-08 / 2.54997287465458e-07 0.016462516 5 37 CHGB_1 0.0000004668 0.01797077169605779 / 0.01038558151359997 / 0.03995334833105726 / 0.001300447845463061 / 0.02829515218286432 1.9938343577981134e-14 / 2.978187999752288e-14 / 0.0001540200268173068 / 6.798337935097158e-05 / 2.4772197524644612e-08 0.01958106 5 38 MLKL_1 0.0000005037 0.04557109838009256 / 0.020065293234851133 / 0.018782542562548483 / 0.0028710845896819668 / 0.0151749944268713 5.258350011749314e-16 / 3.5233765431361435e-16 / 1.4380692845318856e-14 / 1.6150676172067693e-09 / 2.4525625560555298e-05 0.020493003 5 39 FEZ2_1 0.0000017550 0.031477193589555245 / 0.024379882961236787 / 0.010048470855366752 / 0.011748468267345573 / 0.03714879584420702 6.312935617277429e-10 / 3.7842287030008046e-08 / 2.4657689745274255e-07 / 3.08973568823383e-07 / 2.749086098138227e-07 0.022960562 5 40 ADNP2_1 0.0000001922 0.0026926894174448815 / 0.004075435458657517 / 0.0019491268114425514 / 0.001327102464026624 1.2225480672529466e-06 / 3.0317781765339874e-07 / 5.119644519453932e-07 / 6.547354475139775e-07 0.002511089 4 41 CES2_1 0.0000000854 0.0011256917008427522 / 0.00029984671915346143 / 0.0069928898567800275 / 0.0037176072866771754 5.386350021831899e-08 / 4.097431696633607e-08 / 3.300361146039448e-07 / 2.3865798857407134e-08 0.003034009 4 42 DDR1_2 0.0000037846 0.005811854132542747 / 0.00015027886843801155 / 0.015373655199800797 / 0.010222251543950407 1.3359340041312337e-07 / 0.0004586184985847102 / 3.181191463640303e-05 / 2.4848821642062066e-05 0.00788951 4 43 PTGR1_1 0.0001294867 0.000974029004631184 / 0.010347970561211065 / 0.0033011167578337673 / 0.017006970232444858 3.75794293906824e-10 / 2.742804006281166e-10 / 6.771606681956264e-10 / 4.371488301831706e-09 0.007907522 4 44 LIN7A_1 0.0000001378 0.0003053911694309243 / 0.0008478272697591876 / 0.02960036890335299 / 0.00505471841056208 6.44051592787778e-15 / 1.6309672669483183e-12 / 5.867966338897064e-09 / 9.118314699470778e-11 0.008952076 4 45 SYNCRIP_1 0.0000002054 0.00032880733436267256 / 0.011951324766386422 / 0.0027159743199694653 / 0.02902955003102947 3.348316142238797e-07 / 1.9514280045818426e-06 / 2.6301830086705713e-07 / 7.532993598712855e-08 0.011006414 4 46 EREG_1 0.0000004009 0.013036283678806082 / 0.015688398206555057 / 0.010550376036332488 / 0.006349160970663491 3.9566088865499e-12 / 3.2858827273117755e-10 / 7.373790642942721e-08 / 1.7082322019514156e-10 0.011406055 4 47 C12orf57_1 0.0000023046 0.028957927563687466 / 0.010155427409165514 / 0.002911658631725467 / 0.01482122652336213 5.418786155576515e-08 / 9.894747993886977e-09 / 1.0898528564578497e-05 / 9.693695439206281e-06 0.01421156 4 48 PARP9_1 0.0000003928 0.014588245785000514 / 0.004624429303044866 / 0.027918024199514987 / 0.010739324225736034 1.0885372638586847e-06 / 2.7399829900956533e-05 / 1.1332635442176465e-05 / 0.0019394426591983717 0.014467506 4 49 SLITRK3_1 0.0000015095 0.008527348662485085 / 0.005576784085290364 / 0.03856475377208919 / 0.017395831116316804 4.879058800869575e-10 / 6.089275055540338e-08 / 8.719955641574723e-08 / 1.2488572217128136e-07 0.017516179 4 50 BIRC7_2 0.0000002867 0.007821970573183347 / 0.012845369111074686 / 0.031890899198805917 / 0.02364396066164544 1.415313199875648e-06 / 1.6775105441448168e-06 / 2.9271097438840027e-06 / 4.809721198171681e-07 0.01905055 4 51 ID4_1 0.0000000438 0.003637438547469328 / 0.0035281538483017986 / 0.03136639803264472 / 0.038599008286505046 4.0717260162829775e-06 / 6.566951490305026e-08 / 3.5276667485857833e-07 / 7.44565437001132e-08 0.01928275 4 52 NUCB2_1 0.0000017255 0.015046780105136083 / 0.0032323812044334427 / 0.04240343926485064 / 0.017505946985290035 8.68516823257589e-12 / 1.202306983296894e-07 / 1.0709464975577815e-07 / 3.127569243193228e-07 0.019547137 4 53 PDLIM1_2 0.0000001037 0.015202424481940903 / 0.012748370693134645 / 0.04063751247586265 / 0.022091540973998933 3.14173143142748e-08 / 3.6190255834565276e-06 / 3.7940179795671547e-06 / 4.77087797249951e-05 0.022669962 4 54 RNF219_3 0.0000000003 0.02634863692985202 / 0.03450099983593556 / 0.03513681089329 / 0.015137129753690677 7.261409909964612e-07 / 8.200694456053606e-07 / 4.0053825877934606e-07 / 8.023087556208056e-05 0.027780894 4 55 CTRB2_1 0.0002930973 0.020496866256864702 / 0.028972592148966015 / 0.032049126216131416 / 0.03681214620084693 1.3405501486551371e-06 / 6.226524992191516e-06 / 1.1541305382124772e-05 / 0.003046643299819599 0.029582683 4 56 RAB31_2 0.0000000104 0.006725175164160767 / 0.048022618740457663 / 0.04103625170396066 / 0.04997722883556261 8.150539694234232e-13 / 2.883168259855219e-11 / 1.4028815753928321e-09 / 3.0146813286497465e-07 0.036440319 4 57 INADL_2 0.0000000214 0.0001704720932348638 / 0.001471900435167172 / 0.002014853091681951 0.00015166172573858843 / 6.189932841020127e-05 / 0.0012577263128842932 0.001219075 3 58 DPYSL4_5 0.0000005775 0.0014690065976330497 / 0.00012135998144774518 / 0.002693760101625894 4.6411634719532725e-08 / 2.317754511202282e-05 / 4.294994611664571e-05 0.001428042 3 59 TMEM71_1 0.0000627736 0.004627658102704232 / 0.0006371740222421855 / 0.0004238045362036801 1.0813921624882114e-08 / 2.619185841833522e-07 / 1.5188016611726219e-06 0.001896212 3 60 TPD52L2_1 0.0000003037 0.000823176823593811 / 0.0007924860430472411 / 0.004187597686372937 3.758054827561048e-09 / 6.425156679903907e-10 / 1.2757355615837679e-08 0.00193442 3 61 PDIA3_2 0.0000000000 5.0723783667581744e-05 / 0.009226267029946443 / 0.0017778259882067805 4.9831579429374996e-06 / 1.3486634691146526e-07 / 1.5338596718321366e-05 0.003684939 3 62 KCNK6_1 0.0000030974 0.0014573918997663137 / 0.008577741421710208 / 0.001198103041045066 2.061544572083878e-08 / 3.896450174169792e-08 / 5.769947340059933e-08 0.003744412 3 63 CASP8AP2_2 0.0000000219 0.007099092180854751 / 0.0001545053835362215 / 0.00595076253249461 2.3414789029943654e-08 / 6.895486056880935e-08 / 3.937778269227827e-06 0.004401453 3 64 LIG1_2 0.0000029926 0.00035665903643679 / 2.5410658402422594e-05 / 0.014175997822512453 2.1508604917775794e-09 / 1.880923327455265e-08 / 1.4976701341341075e-07 0.004852689 3 65 ARVCF_1 0.0000000809 0.001267397044740127 / 0.003808062774578335 / 0.01865963988831641 3.633196454799821e-07 / 1.9057080324447833e-06 / 7.799389653993747e-07 0.0079117 3 66 PPP1R13L_1 0.0000006399 0.026512261541912406 / 8.131569425129391e-05 / 1.125309447182209e-05 2.5138651999817746e-07 / 6.409504618492529e-08 / 2.5997819819707715e-07 0.008868277 3 67 ELL2_1 0.0000000404 0.0018371780594793963 / 0.02029407943779478 / 0.005548792280102234 2.455332869218628e-08 / 3.107620037340903e-07 / 5.894237364187611e-06 0.009226683 3 68 TMEM74_1 0.0000000714 0.01038558151359997 / 0.01797077169605779 / 0.001300447845463061 1.1935648767376756e-12 / 3.737531077554552e-12 / 0.00012280075259138036 0.0098856 3 69 SH3KBP1_1 0.0000012067 0.012901388332189151 / 0.011880485771633283 / 0.005801481063585688 5.030397982975877e-06 / 9.894710679501381e-06 / 3.451000359467373e-05 0.010194452 3 70 AGXT2L2_4 0.0000000778 0.000513024270655123 / 0.030480389193308928 / 3.516928306401037e-05 1.0557144142948509e-10 / 9.649265913114177e-08 / 2.335866075829399e-06 0.010342861 3 71 FLNA_1 0.0006415808 0.02547058360769006 / 0.007922064339996648 / 0.0028656541081260025 2.1400622545568232e-11 / 9.470548049612122e-08 / 4.4822333426382254e-07 0.012086101 3 72 EVPL_1 0.0000007816 0.029829074750389078 / 0.0017371710506312126 / 0.008885340407261452 1.5237448098566468e-14 / 3.468917372397795e-07 / 8.845088917447386e-07 0.013483862 3 73 ITPRIPL1_1 0.0000009682 0.008791850806005239 / 0.005999339290583331 / 0.02786434125186579 1.870754955730307e-08 / 2.8287486016651227e-07 / 2.360872288601893e-06 0.01421851 3 74 MFSD5_3 0.0000006508 0.03071092956608319 / 0.003938218615229689 / 0.008114190972116433 1.5496424572725938e-08 / 3.2554288938109525e-07 / 1.0112718240540003e-07 0.014254446 3 75 IL31RA_1 0.0002445888 0.02204380039340295 / 0.0012839803246042464 / 0.02580532183784653 3.674619339449928e-07 / 4.43344243632212e-07 / 1.71578946301816e-07 0.016377701 3 76 PTP4A3_1 0.0000314449 0.020414472805311466 / 0.0014693336498995695 / 0.028891732420473607 4.776201023875552e-11 / 1.3766382593509082e-07 / 2.9989438068961905e-07 0.01692518 3 77 MMP14_1 0.0002190770 0.04352684110019303 / 0.004148689189670186 / 0.007178678169977374 7.605828771352425e-12 / 1.360797271795892e-07 / 5.390408897387927e-06 0.018284736 3 78 CAND2_3 0.0000026658 0.028895401482093127 / 0.0009805310391307427 / 0.027607746587453963 1.9907164721328134e-09 / 1.290177089971291e-07 / 1.422741749737834e-07 0.019161226 3 79 ZNF292_5 0.0000000002 0.015104769480539766 / 0.026666883622270408 / 0.017197326894837075 4.1769031641265797e-11 / 1.3947688771774266e-09 / 6.03866098049317e-10 0.019656327 3 80 EPSTI1_1 0.0000073158 0.021559234330291194 / 0.018300289055475042 / 0.02003497685558975 1.6504093087898275e-06 / 3.9975165582205597e-05 / 0.0030284224519400325 0.019964833 3 81 CD97_5 0.0000002610 0.0038275409770200564 / 0.019102004865160463 / 0.037465966805106755 3.7683675686710715e-11 / 9.765240850418052e-10 / 9.834582681938526e-09 0.020131838 3 82 POLE4_5 0.0000000093 0.043632422318038745 / 0.0070119701213412116 / 0.014099632537537078 8.269976083603455e-08 / 5.714696518125464e-08 / 1.8209465254324085e-07 0.021581342 3 83 ZDHHC5_2 0.0009125715 0.029337781272574574 / 0.010806162088221837 / 0.028710223635555462 2.0943141147316446e-08 / 5.3448156529365833e-08 / 1.3376144680099656e-06 0.022951389 3 84 CAV1_1 0.0000013507 0.026222968344836436 / 0.006833233979899956 / 0.03977242799449647 3.7284098504062e-09 / 1.981682163269309e-06 / 3.7034676836929953e-06 0.02427621 3 85 PRDM15_1 0.0000000097 0.005780178191260254 / 0.0347977957945877 / 0.03765009109633616 4.1060665120296455e-08 / 1.8022427394306964e-06 / 1.2329107436658844e-06 0.026076022 3 86 TXNL4A_1 0.0000015245 0.022383216654320942 / 0.019379827420147825 / 0.04981058007691468 1.0003973542061314e-07 / 8.318120908222264e-07 / 1.8197652803291898e-07 0.030524541 3 87 PITX1_1 0.0000080593 0.022158530235155818 / 0.031511227848390264 / 0.04273165395476099 4.328726238704806e-08 / 4.785592074987919e-06 / 4.026072305691093e-05 0.032133804 3 88 CDCA5_1 0.0000010967 0.00020876871631167866 / 1.4383640936438872e-05 3.9804264133636086e-05 / 7.242291833169782e-06 0.000111576 2 89 S100A8_1 0.0000173360 0.00032665136423885464 / 0.001217467053354236 6.539606399624481e-07 / 3.473013871109409e-05 0.000772059 2 90 ZNF345_2 0.0000000001 0.0027538076156700553 / 0.0004164659422400142 5.581451003007147e-05 / 2.582604692500973e-05 0.001585137 2 91 CXXC1_2 0.0000000039 0.0037862695623801213 / 0.0005840830556010548 5.223754637766254e-09 / 5.323504510648734e-08 0.002185176 2 92 ANO4_1 0.0000001136 0.004075435458657517 / 0.001327102464026624 3.235805354734205e-09 / 2.3414451573295386e-08 0.002701269 2 93 STAG2_1 0.0000009873 0.0009656381268940972 / 0.004460012570027854 1.0115034206791287e-06 / 5.753841279635619e-06 0.002712825 2 94 PBX4_1 0.0000007099 0.0037817634953029654 / 0.004617838797443333 2.7021040256543387e-08 / 9.484222614246193e-06 0.004199801 2 95 RRM1_1 0.0000018281 0.00020876871631167866 / 0.010067369603256736 2.998747278117476e-12 / 3.3209239192147915e-07 0.005138069 2 96 NUPL1_2 0.0000000000 0.00041289281227492434 / 0.011652453812603707 1.0657713091915916e-05 / 1.3751517277887033e-05 0.006032673 2 97 MCFD2_2 0.0000002619 0.011150109007006106 / 0.0014577507615148278 2.5410316626468867e-07 / 2.943498549327363e-07 0.00630393 2 98 IKBKAP_1 0.0000058887 0.012665982332335715 / 0.00011000641224999337 1.37456436935247e-06 / 3.934205458402021e-07 0.006387994 2 99 KHK_2 0.0000008186 0.00035665903643679 / 0.014175997822512453 1.4320134905312087e-10 / 9.941441418824106e-06 0.007266328 2 100 SEMA4B_1 0.0000003052 0.0015843420398457381 / 0.015326901145981139 1.468853625012769e-07 / 6.70265240601655e-08 0.008455622 2 101 CEP41_1 0.0000001044 0.002099065390574213 / 0.015250218982745749 1.5608353601998867e-06 / 2.2562783101267498e-06 0.008674642 2 102 DTX3L_1 0.0000012287 0.014588245785000514 / 0.004624429303044866 4.3810913690562183e-07 / 1.043509176420455e-05 0.009606338 2 103 SMC2_1 0.0028804091 0.013707617481622131 / 0.006160764737320071 2.8848576349790795e-08 / 3.01310962529332e-06 0.009934191 2 104 HDAC6_1 0.0009422566 0.010972403654712403 / 0.009810990348338811 1.4716710804724593e-08 / 1.7471497758357106e-07 0.010391697 2 105 KDM3A_1 0.0000075561 0.006171913156047586 / 0.014901187095494001 9.834101497765351e-06 / 2.6427885077789545e-05 0.01053655 2 106 DCAKD_1 0.0000000370 0.0018371780594793963 / 0.02029407943779478 2.2436458658220796e-06 / 3.459304592667202e-06 0.011065629 2 107 DUSP5_1 0.0000000812 0.0018371780594793963 / 0.02029407943779478 8.010663169482405e-08 / 1.019028088460542e-05 0.011065629 2 108 PRPF40A_2 0.0000001288 0.014088198537650237 / 0.008403090707899564 5.6662577214788655e-06 / 5.296682535807921e-06 0.011245645 2 109 PPIB_4 0.0000014621 0.0009023360158888423 / 0.024925919514816482 4.368833166819811e-08 / 1.5361134806777145e-05 0.012914128 2 110 ERAP2_2 0.0000000000 0.012146048132262622 / 0.016053861578409306 8.639554915354646e-08 / 3.070087173430692e-07 0.014099955 2 111 BAALC_1 0.0000002690 0.01038558151359997 / 0.01797077169605779 1.6931423038276145e-08 / 1.1971112083511357e-08 0.014178177 2 112 CACNA2D2_1 0.0000006401 0.01038558151359997 / 0.01797077169605779 3.602719217532972e-10 / 4.92697188032859e-10 0.014178177 2 113 CNPY4_1 0.0000002878 0.013815890119720394 / 0.014734308310181646 1.4477884917386144e-08 / 1.2870154644475552e-06 0.014275099 2 114 ANO5_1 0.0000004289 0.01945182673395856 / 0.010144750097293938 1.0116195313294412e-06 / 1.0659601228586417e-07 0.014798288 2 115 KLK6_2 0.0000031514 0.010648596334043373 / 0.01921308313009029 6.133714219132002e-07 / 2.6008835809083705e-06 0.01493084 2 116 TNIP2_1 0.0000070282 0.026512261541912406 / 0.0034616019934828575 1.2306882876630733e-08 / 9.976408891048964e-06 0.014986932 2 117 KCNJ11_4 0.0000008906 0.000513024270655123 / 0.030480389193308928 9.976114533861802e-12 / 1.3939033644956155e-06 0.015496707 2 118 MED14_1 0.0000001777 0.002121580446747506 / 0.02895588272033544 7.223100165739173e-08 / 5.7035521946275234e-06 0.015538732 2 119 PDGFC_3 0.0000264872 0.019513649031375167 / 0.01309714342199912 6.270077252140188e-07 / 9.870611279741555e-05 0.016305396 2 120 SLFN12_2 0.0000134765 0.02168635011054641 / 0.01167533043285143 1.966242069154016e-09 / 3.0933346339022715e-08 0.01668084 2 121 PDP1_5 0.0000352407 0.026311459966079555 / 0.007838360079130574 4.024957504543219e-05 / 1.4145520941653468e-05 0.01707491 2 122 IER5L_1 0.0000221943 0.02740923337273586 / 0.007187884748118219 4.3782241525162567e-08 / 1.83420306508174e-08 0.017298559 2 123 ABCA5_2 0.0000000000 0.026787063397349216 / 0.00879535947608833 1.3685460854987295e-06 / 8.008743570631834e-06 0.017791211 2 124 CABP7_1 0.0000019025 0.027796287019492286 / 0.008385988903950798 5.44509537364398e-08 / 4.285397797391745e-06 0.018091138 2 125 FCRLB_5 0.0000000126 0.029561026010091924 / 0.009477250370701233 8.716818657445855e-09 / 3.812867727785123e-08 0.019519138 2 126 TIGD3_1 0.0000185890 0.004581158169040506 / 0.0362634468993579 1.1724478296921851e-13 / 2.0363624639109813e-05 0.020422303 2 127 ZNF295_1 0.0000305440 0.026753893459817307 / 0.01508657655367455 2.7477807935711586e-07 / 1.7656093493156047e-07 0.020920235 2 128 PLD2_1 0.0000002785 0.027334357885610883 / 0.015006814582667545 6.430412303297122e-07 / 6.394643388050702e-07 0.021170586 2 129 CD55_1 0.0000001511 0.0033161838556922097 / 0.04158968004878196 6.746452037536084e-10 / 2.2063569025007715e-08 0.022452932 2 130 QKI_3 0.0000181952 0.005022174375240862 / 0.042671396636541896 3.032049011104229e-07 / 3.826421197615377e-07 0.023846786 2 131 MZT1_1 0.0000022280 0.0014965558133177162 / 0.046327505690930644 5.073920441583328e-06 / 6.37180443076072e-06 0.023912031 2 132 SEMA7A_1 0.0000140236 0.03342502222700243 / 0.015261311481267638 4.5276764265942424e-06 / 2.6190564781077353e-06 0.024343167 2 133 ROR2_1 0.0000162778 0.02545372903328934 / 0.02593175339775004 5.907585641697503e-08 / 1.241188472253612e-06 0.025692741 2 134 TRIP6_1 0.0000020904 0.038556379049173375 / 0.013202467191346512 2.7542851202738477e-08 / 5.023495130487458e-08 0.025879423 2 135 C14orf142_1 0.0000007942 0.005868270029793827 / 0.046553563135817905 9.376272681986819e-08 / 4.128986695162416e-06 0.026210917 2 136 ZEB1_2 0.0000468499 0.0213162921786289 / 0.0376737496455549 9.176186713429999e-08 / 2.4212534015690606e-05 0.029495021 2 137 NIP7_2 0.0000000218 0.03316581736784557 / 0.0271384576648737 4.075740819100947e-06 / 5.399297858392524e-06 0.030152138 2 138 GNAO1_1 0.0000005231 0.033760894472022615 / 0.026780216732580863 1.499270713634952e-09 / 1.217458355445439e-05 0.030270556 2 139 FGF9_1 0.0000005137 0.03951670000167351 / 0.02495147370057548 2.989061419962864e-12 / 1.737392805769214e-09 0.032234087 2 140 SERINC3_1 0.0000008268 0.026334033069056118 / 0.03845067832601619 9.100407986778662e-07 / 3.240588908989103e-07 0.032392356 2 141 RSBN1_1 0.0000010033 0.026040435274654685 / 0.03886956807554024 2.221315610307105e-11 / 9.033061104976416e-08 0.032455002 2 142 ARVCF_1 0.0000002829 0.026222968344836436 / 0.03977242799449647 7.483862897069276e-07 / 5.432934252510295e-07 0.032997698 2 143 DTL_1 0.0000076383 0.039542232891747735 / 0.02707374976179199 3.398617522656201e-09 / 9.59460633791626e-07 0.033307991 2 144 SRSF7_1 0.0000002874 0.0347977957945877 / 0.03765009109633616 6.847127318749837e-07 / 3.116230608631045e-07 0.036223943 2 145 IFIT5_2 0.0004701599 0.0364953120948139 / 0.037232340056821626 4.399782821011542e-06 / 1.7393118846309304e-05 0.036863826 2 146 NARF_1 0.0000022881 0.03953940913634625 / 0.03994379945480948 1.1301210005302875e-08 / 2.133257245226995e-06 0.039741604 2 147 CASP8_1 0.0000198034 0.0464587665387115 / 0.0401631181784738 1.601941993185719e-16 / 2.6864531857041694e-11 0.043310942 2 148 IL17RB_1 0.0000067045 0.04546047598682959 / 0.04334588252631349 3.033905276829337e-08 / 1.0262557517569413e-05 0.044403179 2 149 SLC15A2_1 0.0000014155 5.681660863421172e-05 1.5961846511181405e-05 5.68166E-05 One 150 SAR1B_1 0.0000005513 0.00013784539893700994 6.454907031718106e-06 0.000137845 One 151 TTC1_1 0.0000004017 0.00013784539893700994 2.336682885494787e-10 0.000137845 One 152 CRP_2 0.0000000078 0.00016321344400834376 5.576182275696905e-05 0.000163213 One 153 GGCX_1 0.0000076825 0.00017247402077598097 1.2879118524126266e-07 0.000172474 One 154 SOX9_1 0.0000013296 0.0001839790498817074 7.272296164227475e-06 0.000183979 One 155 DLX5_3 0.0000326962 0.0003180382059133217 4.664951986768726e-07 0.000318038 One 156 SNRNP25_3 0.0000000234 0.0003180382059133217 3.3152672324048814e-05 0.000318038 One 157 UHRF1BP1L_1 0.0000001071 0.000349384308330678 2.1709474268278766e-06 0.000349384 One 158 PAPD4_1 0.0000249556 0.0004361114375544852 1.8113390561602514e-06 0.000436111 One 159 ADAMTS14_1 0.0000437150 0.0005765804746846872 6.590376972707598e-05 0.00057658 One 160 FAT2_1 0.0000012964 0.0006381430782712855 4.603295730722451e-06 0.000638143 One 161 ZNF750_2 0.0000000299 0.0007846622552824629 4.022726992390641e-05 0.000784662 One 162 BTG2_1 0.0000093251 0.0008391695317782487 3.5774320349838873e-07 0.00083917 One 163 PIGB_4 0.0000000787 0.0009023360158888423 2.2878500220993498e-11 0.000902336 One 164 WHAMM_4 0.0000010450 0.0009023360158888423 1.1651758424474298e-06 0.000902336 One 165 PELI2_2 0.0000000141 0.0012894304816227693 8.58480971255917e-08 0.00128943 One 166 RPS5_1 0.0000036423 0.00134963344272631 2.405506994776735e-06 0.001349633 One 167 DALRD3_1 0.0000008658 0.0013670815874214685 1.1128380015615429e-08 0.001367082 One 168 ANKRD22_1 0.0000009306 0.0014573918997663137 3.138691465570034e-07 0.001457392 One 169 AGBL4_5 0.0000001940 0.0014690065976330497 3.7344924411524894e-05 0.001469007 One 170 DCUN1D2_1 0.0000001810 0.0014965558133177162 2.6955640062447783e-06 0.001496556 One 171 RAP2A_1 0.0000043749 0.0014965558133177162 3.643928917883914e-07 0.001496556 One 172 TEX30_1 0.0000077886 0.0014965558133177162 7.322882011832241e-07 0.001496556 One 173 CPNE8_1 0.0000012221 0.0015823634728436365 1.0569424770637742e-11 0.001582363 One 174 IFIT3_1 0.0000007653 0.0015904564617824036 2.30780238404599e-06 0.001590456 One 175 KCNMB2_1 0.0000003403 0.0015904564617824036 1.6585833620905925e-08 0.001590456 One 176 TRIM21_1 0.0000000854 0.0015904564617824036 2.1285881318643393e-08 0.001590456 One 177 NAP1L4_1 0.0000087541 0.0017153185879343034 7.850131843413566e-06 0.001715319 One 178 GALNT3_1 0.0000354752 0.0020476470911988563 2.5573822901107337e-05 0.002047647 One 179 EVL_1 0.0000019885 0.002058130936511972 2.717135803874761e-09 0.002058131 One 180 TSPAN8_1 0.0000003090 0.0021489267613823003 1.017187347139058e-05 0.002148927 One 181 RUNDC3B_1 0.0000041888 0.0024846662085153902 1.016379726019311e-05 0.002484666 One 182 CCDC113_1 0.0000076744 0.0025150135152389474 1.5032272736368673e-06 0.002515014 One 183 PIAS2_2 0.0000001786 0.0025152679462084955 2.2483779303553648e-06 0.002515268 One 184 ALG14_1 0.0000072016 0.0026041641330007506 0.0006233183228222267 0.002604164 One 185 TAF11_1 0.0000009139 0.002687295907204792 0.00012476609977995568 0.002687296 One 186 KCNK9_1 0.0011919577 0.0028046841261304568 1.376632392689302e-07 0.002804684 One 187 LRRC8A_1 0.0000035240 0.0032327742303384166 6.356756636137029e-06 0.003232774 One 188 TMEM151B_1 0.0000007358 0.0032636781607269594 1.8328686422960692e-06 0.003263678 One 189 C10orf76_1 0.0000881113 0.003434642569271992 7.673926087001424e-06 0.003434643 One 190 NXNL2_1 0.0000597168 0.003544372498506248 3.942459986260573e-08 0.003544372 One 191 TCEB3_1 0.0005226535 0.0037150885246972363 0.00024989766039529933 0.003715089 One 192 CPEB2_2 0.0000010060 0.003774743841069769 2.850551586644877e-06 0.003774744 One 193 TUBB_1 0.0000000607 0.0037817634953029654 8.334855345042203e-07 0.003781763 One 194 UBE2H_1 0.0000005261 0.004043548766154216 2.7343581965712453e-07 0.004043549 One 195 TM9SF4_1 0.0000000634 0.004075435458657517 1.208568331650002e-06 0.004075435 One 196 ZNF250_1 0.0001614132 0.004581158169040506 8.906742496574832e-08 0.004581158 One 197 ARSD_1 0.0000007813 0.004617838797443333 4.0431258909202725e-06 0.004617839 One 198 ZBED5_5 0.0000000106 0.005222164163583828 1.6160725995889468e-06 0.005222164 One 199 TEAD3_3 0.0000036458 0.0053872635110084445 4.1927795302166964e-05 0.005387264 One 200 PAICS_1 0.0023017121 0.005473511421368178 0.001803574650219185 0.005473511 One 201 SDSL_1 0.0000016496 0.006403254151390212 7.017651789933182e-08 0.006403254 One 202 SP140L_1 0.0000004574 0.00690906973800756 1.4293392545039821e-08 0.00690907 One 203 VEZF1_1 0.0000006200 0.007512524281614588 4.015799360215652e-07 0.007512524 One 204 TSR2_2 0.0000001115 0.00807009151771129 5.455073735317627e-08 0.008070092 One 205 LRFN5_1 0.0001487507 0.00837748774812484 1.765094200227484e-07 0.008377488 One 206 HMOX1_3 0.0000000049 0.009019901589667713 3.3116226812292643e-07 0.009019902 One 207 OAF_2 0.0000021448 0.010087189185487436 6.611044842333954e-06 0.010087189 One 208 C1orf198_1 0.0047644878 0.01058743988900243 5.33047484084318e-06 0.01058744 One 209 RNF145_1 0.0000015182 0.010685297092225236 3.4948918270211384e-09 0.010685297 One 210 TFDP1_2 0.0000000087 0.011664876607743443 1.0484496266632918e-06 0.011664877 One 211 TRIM33_5 0.0000006448 0.012312852331877405 5.823849535285043e-07 0.012312852 One 212 BRD1_1 0.0000056060 0.012444591121133452 9.00450493226787e-08 0.012444591 One 213 RAB18_1 0.0000000557 0.012469136109983507 7.808669892591835e-06 0.012469136 One 214 DOK6_1 0.0000225131 0.0126479390211753 2.9116700927572027e-07 0.012647939 One 215 TMEM132D_1 0.0000007064 0.014125552794811447 0.00013933215110235875 0.014125553 One 216 RBKS_1 0.0000039408 0.014510361909036783 1.369930658748886e-10 0.014510362 One 217 SDPR_1 0.0000144016 0.015098577756027905 1.2200927403044487e-06 0.015098578 One 218 HADHB_3 0.0000011607 0.015198702702676786 4.67481146425626e-06 0.015198703 One 219 RAB2B_1 0.0000015355 0.015525342789786052 9.240171811293034e-08 0.015525343 One 220 CLSPN_2 0.0015604856 0.015681284994245294 4.787605013931291e-06 0.015681285 One 221 LRCH2_1 0.0000013499 0.016913586137948928 3.239478361523596e-06 0.016913586 One 222 RIC8B_1 0.0000258855 0.018613210669019453 2.5972193291243487e-07 0.018613211 One 223 SNX17_1 0.0000005150 0.0187791714585435 7.832292477544212e-06 0.018779171 One 224 HPS1_3 0.0000193423 0.020032646836294014 2.651724363437782e-08 0.020032647 One 225 TNNT3_1 0.0000037981 0.02003497685558975 0.0024373027878036467 0.020034977 One 226 MPHOSPH9_1 0.0000010033 0.020273128817757814 5.7180542135867475e-06 0.020273129 One 227 PCDH7_1 0.0000026780 0.020321552294661337 1.8717328001192637e-06 0.020321552 One 228 NSL1_1 0.0000025413 0.020596934169840004 1.6439984899784691e-06 0.020596934 One 229 ALG9_1 0.0001111425 0.022935884489828733 1.7377644622722088e-06 0.022935884 One 230 PDE12_1 0.0000004658 0.0233155726865293 1.5807742224423866e-05 0.023315573 One 231 PAPSS2_1 0.0000007706 0.024338654294994898 9.283888609188878e-08 0.024338654 One 232 ZFHX2_1 0.0000004187 0.02464096203134193 2.8806779697573074e-06 0.024640962 One 233 TFG_2 0.0000000179 0.02485916255363959 5.4417829495431724e-05 0.024859163 One 234 IL15RA_1 0.0000004083 0.02498090614719385 2.4652810837821435e-06 0.024980906 One 235 MBTD1_1 0.0000000005 0.02498090614719385 2.476481267971609e-05 0.024980906 One 236 TMPRSS4_1 0.0001737302 0.02527275878591322 4.96032498878352e-07 0.025272759 One 237 APBB1_1 0.0007952642 0.025477899370092264 1.1177566606698288e-07 0.025477899 One 238 MAD2L2_1 0.0000650171 0.025477899370092264 7.015450869623152e-07 0.025477899 One 239 MAP4_1 0.0000021567 0.026512261541912406 5.151370139997939e-07 0.026512262 One 240 GLTP_1 0.0000002645 0.02685009566751369 1.2940153369292968e-05 0.026850096 One 241 CECR2_1 0.0000034126 0.02695039496870006 4.8390480434201144e-06 0.026950395 One 242 RUFY1_1 0.0000299227 0.027256120811697704 8.232591388149916e-11 0.027256121 One 243 LRRN1_3 0.0000000006 0.027852483618169322 2.4617114447232193e-06 0.027852484 One 244 ATRIP_1 0.0000459410 0.028297897669394324 3.581872487568641e-06 0.028297898 One 245 NADKD1_1 0.0001614851 0.030463092594199083 9.476649004029163e-08 0.030463093 One 246 DAPL1_5 0.0000001131 0.03247309026025267 1.063046591606967e-06 0.03247309 One 247 HSD17B10_1 0.0000356915 0.03300637436842342 3.315891641410488e-08 0.033006374 One 248 CTSL1_5 0.0000012024 0.033080135108199266 2.1760418610560375e-10 0.033080135 One 249 PPM1F_2 0.0000003736 0.033564554983805193 6.023420324819565e-06 0.033564555 One 250 SERPINB8_1 0.0000004020 0.03395639101055327 7.590142415124812e-06 0.033956391 One 251 LEPREL4_1 0.0000031108 0.03517044127467462 9.048855093781964e-06 0.035170441 One 252 HIRA_1 0.0000071773 0.036656389092885745 6.41338762201109e-06 0.036656389 One 253 MET_2 0.0000048647 0.03675726542857143 4.0499324464518144e-07 0.036757265 One 254 ST18_2 0.0000003070 0.03675726542857143 2.1367286772341655e-08 0.036757265 One 255 IFI35_1 0.0000001142 0.037485659344956734 1.8673858169252516e-08 0.037485659 One 256 CNKSR3_1 0.0000002224 0.0380562899913768 1.4065162180136549e-05 0.03805629 One 257 NFKBIZ_1 0.0002437797 0.038514781543232596 2.106101897324396e-07 0.038514782 One 258 TFPI_1 0.0050804078 0.038514781543232596 7.186644444797165e-08 0.038514782 One 259 PDIA6_1 0.0000012653 0.038781900239634945 1.1794828467593882e-06 0.0387819 One 260 RSF1_3 0.0000000002 0.03932106882555421 1.1649216389446077e-06 0.039321069 One 261 MYO1E_2 0.0000209873 0.039881619914679374 4.562099888852519e-11 0.03988162 One 262 UBAP1_1 0.0000010913 0.040258840897526606 2.649945837106964e-07 0.040258841 One 263 GFER_1 0.0000199213 0.041058990270996985 1.013140578199153e-06 0.04105899 One 264 C17orf75_1 0.0000001475 0.041863358380761856 2.011957469008045e-05 0.041863358 One 265 TTC9B_1 0.0000199304 0.0440605439544666 1.3515245965925785e-06 0.044060544 One 266 FAM198B_1 0.0000000398 0.04544630802892216 1.2975083762851168e-06 0.045446308 One 267 DCTD_1 0.0000002300 0.045495607074215974 9.613702843960257e-08 0.045495607 One 268 ZSCAN16_1 0.0000002003 0.04907931555044797 6.364155025566868e-08 0.049079316 One 269 CCDC14_2 0.0000000040 0.049412789880137475 1.0956612304568067e-06 0.04941279 One 270 TRIP11_1 0.0000106522 0.049477459520320635 3.616757502303368e-08 0.04947746 One 271 NKAIN2_1 0.0000341788 0.04968678580260802 1.3235403934017564e-06 0.049686786 One 272 NT5E_1 0.0000065065 0.04968678580260802 1.050035169104463e-10 0.049686786 One 273 PPP1R14A_5 0.0000105571 0.00022092891960888485 5.27242603779648e-05 0.000220929 One 274 CDH2_1 0.0001087650 0.0005511270416472728 0.0004028031199308745 0.000551127 One 275 EMC3_1 0.0000000114 0.0006784104611363802 3.0652280007137936e-05 0.00067841 One 276 NCAPG2_1 0.0000228504 0.0007900043500214932 0.0004768223953633258 0.000790004 One 277 OR13H1_2 0.0011906247 0.024195410263062368 0.024770686509726116 0.02419541 One

Table 12 lists the FRHs associated with the sarcoma cancer drug, and the markers defining the sarcoma cancer drugs and FRHs associated therewith.

In addition, [Table 13] summarizes the results of calculating the degree of reactivity (P-value) of FRHs shown in [Table 12].

In these tables, FRH is expressed in the form of "FRH name_number of included markers", and "Var_Exp (pval)" means the correlation (Pvlaue) value of each marker on the corresponding gene expression, and "Var_Drug (pval)" Means the correlation (Pvlaue) value of the corresponding marker on the reactivity of the drug, and according to the order of drugs listed in [Table 12], the reactivity correlation value for each drug is divided into the classification factor 『/』 `` Exp_Drug (pval) '', the gene expression has a correlation (Pvlaue) value for drug reactivity according to the order of drugs listed in [Table 12], and "Ave_VarDrug (pval)" is "Var_Drug ( pval) 』means the average value of the calculated values, and『 Rank 』means the number of sarcoma cancer drugs in which the corresponding FRH significantly affects.

From these reactivity verification results, the lower the Var_Exp (pval), the lower the Var_Drug (pval) and its average value, Ave_VarDrug (pval), the lower the Exp_Drug (pval), the higher the Rank number, the corresponding marker determines drug reactivity It can be judged that the effectiveness is high as a biomarker.

Meanwhile, in FIG. 35, the correlation values (P-vlaue) of sarcoma cancer drugs of the major biomarkers among the biomarkers listed in Table 12 are graphically displayed, and in FIG. 36, the genes expressed by the main biomarkers Correlation values (P-vlaue) values for the fields and sarcoma cancer drugs are plotted.

Reactive biomarkers for sarcoma cancer drugs No. FRH Drug DrugType Var (marker) One LUC7L_5 263_FR-180204 / 310_YM201636 / 294_MPS-1-IN-1 / 228_KIN001-102 / 326_GSK690693 / 288_KIN001-055 / 303_PIK-93 / 1498_AZD6244 / 305_TPCA-1 / 271_VNLG / 124 / 245_UNC0638 / 330_XMD13-2 rescreen) / 286_KIN001-236 / 344_THZ-2-49 / 256_JW-7-24-1 / 185_OSI-906 / 304_SB52334 / 265_Tubastatin A / 283_GSK2126458 / 253_XMD14-99 / 346_THZ-2-102-1 / 298_OSI-930 / 257_NPK76- II-72-1 / 1372_Trametinib / 331_QL-X-138 / 1014_RDEA119 / 290_KIN001-260 / 221_TAK-715 / 252_WZ3105 / 276_CAY10603 / 287_KIN001-244 / 306_TG101348 / 179_5-Fluorouracil / 301_Pu 300_CX-5461 / 226_GSK1070916 / 1010_Gefitinib / 281_CH5424802 / 1242_ (5Z) -7-Oxozeaenol / 223_ZSTK474 / 1011_ABT-263 / 292_Masitinib / 1008_Methotrexate / 175_PAC-1 / 299_OSI-762 / 328_SNX-2112 / 254_AC220 / 211_TL-2-105 / 274_Belinostat / 260_NG-25 / 279_BIX02189 / 152_CP466722 / 272_AR-42 / 136_Mitomycin C / 222_BX-912 / 208_SB-715992 / 184_BMS-754807 / 56_WH-4-023 / 1218_JQ1 / 1091_BMS-536924 / 1017_Olaparib / 341_EX-527 / 261_TL-1-85 / 1259_BMN-673 / 1060_PD-0325901 / 205_BMS-708163 / 196_Phenformin / 302 309_Y-39983 / 1020_Lenalidomide / 1005_Cisplatin / 1262_UNC1215 / 329_QL-XI-92 / 1495_Olaparib / 295_NVP-BHG712 / 258_STF-62247 / 200_LAQ824 / 1026_17-AAG / 1039_SL 0101-1 / 260 260 / 235_QL-XII-47 / 203_BMS-345541 / 182_Obatoclax Mesylate / 1012_Vorinostat / 1013_Nilotinib / 1175_AG-014699 / 135_Gemcitabine / 266_Zibotentan / 178_BAY 61-3606 / 332_XMD15-27 / 1264_SGC09 / 1264_SGC erk_mapk / other / mitosis / pi3k / pi3k / other / pi3k / erk_mapk / other / chromatin / chromatin / other / egfr / erk_mapk / other / cell_cyc / other / igfr / rtk / chromatin / pi3k / rtk / cell_cyc / rtk / mitosis / erk_mapk / other / erk_mapk / other / jnk_p38 / other / chromatin / pi3k / other / DNArep / cell_cyc / chromatin / other / other / mitosis / egfr / rtk / other / pi3k / apop / rtk / DNArep / apop / tor / pi3k / chromatin / mitosis / other / rtk / erk_mapk / chromatin / other / other / g_integrity / chromatin / DNArep / pi3k / mitosis / igfr / abl / chromatin / igfr / g_integrity / other / other / g_integrity / erk_mapk / other / metabol / pi3k / cytoskeleton / other / DNArep / other / rtk / g_integrity / rtk / other / chromatin / other / erk_mapk / egfr / cell_cyc / rtk / metabol / pi3k / other / other / apop / chromatin / abl / g_integrity / DNArep / other / other / other / chromatin / tor / g_integrity / cytoskeleton 1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G / 5_141432375_A_C / 22_18847351_G_C 2 FZD3_1 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 223_ZSTK474_2 / 283_Omipalisib_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 281_Alectinib_2 / 304_SB52334_3 / 224_AS605240_3 / 282_Pelitinib_2 / 253_XMD14-99_3 / 263_FR-180204_3 / 326_GSK690693_3 / 152_CP466722_3 / 225_Genentech Cpd 10_3 / 290_KIN001-260_3 / 330_XMD13-2_3 / 221_TAK-715_2 / 286_KIN001-236_3 / 238_Idelalisib_1 / 299_OSI-027_2 / 272_AR-42_2 / 298_OSI-930_2 / 222_BX-912_3 / 265_Tubastatin A_3 / 275_I-B_I_B_Stable 256_JW-7-24-1_3 / 274_Belinostat_1 / 301_PHA-793887_3 / 219_AT-7519_2 / 303_PIK-93_3 / 252_WZ3105_3 / 329_QL-XI-92_3 / 257_NPK76-II-72-1_3 / 273_CUDC-101_9797_ 261_TL-1-85_3 / 211_TL-2-105_3 / 271_VNLG / 124_3 pi3k / mitosis / pi3k / pi3k / other / mitosis / other / rtk / rtk / pi3k / egfr / rtk / erk_mapk / pi3k / g_integrity / mitosis / other / other / jnk_p38 / other / pi3k / tor / chromatin / rtk / pi3k / chromatin / chromatin / other / chromatin / mitosis / other / other / chromatin / cell_cyc / cell_cyc / pi3k / other / rtk / mitosis / chromatin / igfr / other / other / erk_mapk / chromatin 1_26457907_T_G 3 LMBR1L_3 261_TL-1-85_3 / 281_Alectinib_2 / 291_KIN001-266_3 / 346_THZ-2-102-1_3 / 310_YM201636_3 / 257_NPK76-II-72-1_3 / 344_THZ-2-49_3 / 303_PIK-93_3 / 286_KIN001-236_3 / 256_ 1_3 / 328_SNX-2112_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 287_KIN001-244_3 / 294_MPS-1-IN-1_3 / 260_NG-25_3 / 290_KIN001-260_3 / 345_KIN001-270_3 / 208_Ispinesib 305 -138_3 / 225_Genentech Cpd 10_3 / 299_OSI-027_2 / 273_CUDC-101_2 / 276_CAY10603_3 / 226_GSK1070916_2 / 265_Tubastatin A_3 / 292_Masitinib_1 / 263_FR-180204_3 / 272_AR-42_2 other / rtk / other / cell_cyc / other / mitosis / cell_cyc / pi3k / other / other / other / other / other / pi3k / mitosis / other / other / cell_cyc / mitosis / cell_cyc / other / other / mitosis / tor / chromatin / chromatin / mitosis / chromatin / rtk / erk_mapk / chromatin / g_integrity / pi3k / pi3k 20_35697711_A_C / 7_72949311_A_C / 12_109266204_T_G 4 ACTN2_3 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 228_AKT_inhibitor_VIII_3 / 288_WHI-P97_3 / 328_SNX-2112_3 / 344_THZ-2-49_3_ 260 2_3 / 256_JW-7-24-1_3 / 245_UNC0638_3 / 252_WZ3105_3 / 299_OSI-027_2 / 257_NPK76-II-72-1_3 / 286_KIN001-236_3 / 152_CP466722_3 / 326_GSK690693_3 / 283_Omi_Plato 25_3 / 253_XMD14-99_3 / 226_GSK1070916_2 / 331_QL-X-138_3 / 261_TL-1-85_3 / 279_BIX02189_3 / 223_ZSTK474_2 / 291_KIN001-266_3 / 271_VNLG / 124_3 other / erk_mapk / mitosis / other / pi3k / pi3k / other / other / cell_cyc / other / pi3k / rtk / other / other / chromatin / other / tor / mitosis / other / g_integrity / pi3k / pi3k / cell_cyc / DNArep / other / rtk / mitosis / other / other / other / pi3k / other / chromatin 1_26457907_T_G / 22_18847351_G_C / 22_21127217_C_G 5 UBXN7_2 310_YM201636_3 / 1259_Talazoparib_3 / 344_THZ-2-49_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 263_FR-180204_3 / 256_JW-7-24-1_3_3_ / 124_3 / 301_PHA-793887_3 / 185_Linsitinib_2 / 1017_Olaparib_2 / 253_XMD14-99_3 / 136_Mitomycin-C_1 / 1495_Olaparib_1 / 281_Alectinib_2 / 257_NPK76-II-72-1_3 / 292_Masitinib_1 / 1003_Camptothecin_1 / 290_KIN001-260_3 / 298_OSI-930_2 / 283_Omipalisib_2 / 300_CX-5461_3 / 304_SB52334_3 / 273_CUDC-101_2 / 223_ZSTK474_2 / 299_OSI-027_2 / 331_QL-X-138_3 other / g_integrity / cell_cyc / other / other / mitosis / pi3k / erk_mapk / other / chromatin / mitosis / other / pi3k / chromatin / cell_cyc / igfr / g_integrity / rtk / DNArep / g_integrity / rtk / mitosis / rtk / DNArep / other / rtk / pi3k / other / rtk / chromatin / pi3k / tor / other 22_24252424_G_C / 1_26457907_T_G 6 TRAM2_2 226_GSK1070916_2 / 310_YM201636_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 305_TPCA-1_3 / 299_OSI-027_2 / 228_AKT_inhibitor_VIII_3 / 228_AKT_inhibitor_VIII_3 / 260_AK_3_ 2-102-1_3 / 301_PHA-793887_3 / 222_BX-912_3 / 1259_Talazoparib_3 / 257_NPK76-II-72-1_3 / 283_Omipalisib_2 / 208_Ispinesib Mesylate_2 / 253_XMD14-99_3 / 303_PIK_93_3_39_3_39_3_39 / 286_KIN001-236_3 / 287_KIN001-244_3 / 223_ZSTK474_2 / 225_Genentech Cpd 10_3 / 254_Quizartinib_2 / 265_Tubastatin A_3 / 331_QL-X-138_3 mitosis / other / erk_mapk / other / mitosis / other / other / tor / pi3k / other / jnk_p38 / other / cell_cyc / cell_cyc / pi3k / g_integrity / mitosis / pi3k / mitosis / rtk / pi3k / pi3k / cell_cyc / rtk / pi3k / other / pi3k / pi3k / mitosis / rtk / chromatin / other 1_26457907_T_G / 22_21127217_C_G 7 CDK13_2 326_GSK690693_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 283_Omipalisib_2 / 263_FR-180204_3 / 301_PHA-793887_3 / 331_QL-X-138_3 / 228_AKT_inhibitor_V3_3_3_3_3_3_3_3_3_3 295_NVP-BHG712_3 / 279_BIX02189_3 / 256_JW-7-24-1_3 / 346_THZ-2-102-1_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 226_GSK1070916_2 / 286_KIN001-236_3 / 290_KIN001-260_3 / 290 027_2 / 282_Pelitinib_2 / 223_ZSTK474_2 / 245_UNC0638_3 / 304_SB52334_3 / 302_PI-103_3 / 253_XMD14-99_3 / 328_SNX-2112_3 / 238_Idelalisib_1 pi3k / other / cell_cyc / other / pi3k / erk_mapk / cell_cyc / other / pi3k / mitosis / other / other / chromatin / rtk / other / other / cell_cyc / other / pi3k / mitosis / other / other / mitosis / tor / egfr / pi3k / chromatin / rtk / pi3k / rtk / other / pi3k 1_26457907_T_G / 22_30937565_T_G 8 BCL11B_3 310_YM201636_3 / 344_THZ-2-49_3 / 330_XMD13-2_3 / 263_FR-180204_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2_ 256_JN II-72-1_3 / 303_PIK-93_3 / 290_KIN001-260_3 / 299_OSI-027_2 / 276_CAY10603_3 / 245_UNC0638_3 / 326_GSK690693_3 / 152_CP466722_3 / 283_Omipalisib_2 / 273_CUDC-101_2 / 346_THZ-2-102-1_3 / 223_ZSTK474_2 / 274_Belinostat_1 / 304_SB52334_3 / 279_BIX02189_3 / 1259_Talazoparib_3 / 272_AR-42_2 / 286_KIN001-236_3 / 287_KIN001-244_3 other / cell_cyc / other / erk_mapk / other / pi3k / other / mitosis / rtk / other / mitosis / other / mitosis / pi3k / other / tor / chromatin / chromatin / pi3k / g_integrity / pi3k / chromatin / cell_cyc / pi3k / chromatin / rtk / other / g_integrity / chromatin / other / pi3k 1_26457907_T_G / 5_141432375_A_C / 22_22643666_C_G 9 LONRF1_4 344_THZ-2-49_3 / 288_WHI-P97_3 / 263_FR-180204_3 / 310_YM201636_3 / 330_XMD13-2_3 / 257_NPK76-II-72-1_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 290_KIN001-260_3 / 252-7 24-1_3 / 286_KIN001-236_3 / 228_AKT_inhibitor_VIII_3 / 299_OSI-027_2 / 303_PIK-93_3 / 291_KIN001-266_3 / 279_BIX02189_3 / 346_THZ-2-102-1_3 / 276_CAY10603_3 / 226_GSK1070916_2 / 292_Masitinib_1 / 265_Tubastatin A_3 / 273_CUDC-101_2 / 245_UNC0638_3 / 287_KIN001-244_3 / 152_CP466722_3 / 261_TL-1-85_3 / 208_Ispinesib Mesylate_2 / 1259_Talazoparib_3 cell_cyc / other / erk_mapk / other / other / mitosis / mitosis / other / other / other / other / other / pi3k / tor / pi3k / other / other / cell_cyc / chromatin / mitosis / rtk / chromatin / chromatin / chromatin / pi3k / g_integrity / other / mitosis / g_integrity 1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G / 15_42142087_A_C 10 NUDT16_1 344_THZ-2-49_3 / 330_XMD13-2_3 / 310_YM201636_3 / 273_CUDC-101_2 / 226_GSK1070916_2 / 272_AR-42_2 / 276_CAY10603_3 / 263_FR-180204_3 / 326_GSK690693_3 / 274_Belino_3 Mesylate_2 / 283_Omipalisib_2 / 228_AKT_inhibitor_VIII_3 / 301_PHA-793887_3 / 225_Genentech Cpd 10_3 / 281_Alectinib_2 / 294_MPS-1-IN-1_3 / 299_OSI-027_2 / 1259_Talazoparib_3 / 292_Masitinib_1 / 305_TPCA-1_3 / 298_OSI-930_2 / 290_KIN001-260_3 / 286_KIN001-236_3 / 257_NPK76- II-72-1_3 cell_cyc / other / other / chromatin / mitosis / chromatin / chromatin / erk_mapk / pi3k / chromatin / other / rtk / chromatin / other / mitosis / pi3k / pi3k / cell_cyc / mitosis / rtk / mitosis / tor / g_integrity / rtk / other / rtk / other / other / mitosis 1_26457907_T_G 11 BDKRB1_1 310_YM201636_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 290_KIN001-260_3 / 228_AKT_inhibitor_VIII_3 / 1259_Talazoparib_3 / 344_THZ-2-49_3 / 330_XMD13-2_3 / 136_Mitomy_ 715_2 / 226_GSK1070916_2 / 252_WZ3105_3 / 303_PIK-93_3 / 301_PHA-793887_3 / 346_THZ-2-102-1_3 / 1008_Methotrexate_1 / 304_SB52334_3 / 253_XMD14-99_3 / 257_NPK76-IIG 299_OSI-027_2 / 286_KIN001-236_3 other / mitosis / erk_mapk / other / pi3k / g_integrity / cell_cyc / other / DNArep / other / other / pi3k / rtk / jnk_p38 / mitosis / other / pi3k / cell_cyc / cell_cyc / DNArep / rtk / rtk / mitosis / abl / pi3k / rtk / tor / other 22_22643666_C_G 12 ACVR1B_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 310_YM201636_3 / 290_KIN001-260_3 / 303_PIK-93_3 / 265_Tubastatin A_3 / 276_CAY10603_3 / 225_Genentech Cpd 10_3 / 272_AR-42_2 / 228_AKT_inhibitor_VIII_3 / 274_Belinostat_1 / 253_XMD14-99_3 / 226_GSK1070916_2 / 283_Omipalisib_2 / 185_Linsitinib_2 / 257_NPK76-II-72-1_3 / 223_ZSTK474_2 / 299_OSI-027_2 / 256_JW-7-24-1_3 / 281_Alectinib_2 / 273_CUDC-101_2 / 326_GSK690693_3 / 330_XMD13-2_3 / 291_KIN001-266_3 / 152180 mitosis / other / rtk / other / other / pi3k / chromatin / chromatin / mitosis / chromatin / pi3k / chromatin / rtk / mitosis / pi3k / igfr / mitosis / pi3k / tor / other / rtk / chromatin / pi3k / other / other / g_integrity / erk_mapk 1_26457907_T_G 13 FUCA2_5 310_YM201636_3 / 344_THZ-2-49_3 / 245_UNC0638_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 273_CUDC-101_2 / 288_WHI-P97_3 / 330_XMD13-2_3 -7-24-1_3 / 253_XMD14-99_3 / 304_SB52334_3 / 326_GSK690693_3 / 276_CAY10603_3 / 226_GSK1070916_2 / 271_VNLG / 124_3 / 346_THZ-2-102-1_3 / 257_NPK76-II-72-1_3 / 306e other / cell_cyc / chromatin / erk_mapk / mitosis / pi3k / chromatin / other / other / other / other / pi3k / chromatin / other / rtk / rtk / pi3k / chromatin / mitosis / chromatin / cell_cyc / mitosis / rtk / chromatin / chromatin / other 1_26457907_T_G / 5_141432375_A_C / 22_18847351_G_C / 1_219210601_T_G / 22_22643666_C_G 14 ZNF862_2 226_GSK1070916_2 / 346_THZ-2-102-1_3 / 310_YM201636_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 225_Genentech Cpd 10_3 / 222_BX-912_3-1-2_93_301_93 265_Tubastatin A_3 / 260_NG-25_3 / 290_KIN001-260_3 / 283_Omipalisib_2 / 331_QL-X-138_3 / 328_SNX-2112_3 / 299_OSI-027_2 / 287_KIN001-244_3 / 330_XMD13-2_3 / 211_TL-2-105_3 / 208_Ispinesib Mesylate_2 mitosis / cell_cyc / other / other / mitosis / other / pi3k / mitosis / pi3k / mitosis / cell_cyc / chromatin / other / other / pi3k / other / other / tor / pi3k / other / pi3k / pi3k / other / pi3k / erk_mapk / mitosis 1_26457907_T_G / 22_22759034_G_A 15 JAKMIP2_1 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 298_OSI-930_2 / 252_WZ3105_3 / 1259_Talazoparib_3 / 226_GSK1070916_2 / 326_GSK690693_3 / 306_Fedratinib_2 / 253_XMD14-99_3 / 221_TAK- 715_2 / 305_TPCA-1_3 / 256_JW-7-24-1_3 / 304_SB52334_3 / 301_PHA-793887_3 / 283_Omipalisib_2 / 211_TL-2-105_3 / 208_Ispinesib Mesylate_2 / 290_KIN001-260_3 / 292_MasiLinb_1 185 other / pi3k / other / erk_mapk / mitosis / cell_cyc / other / rtk / other / g_integrity / mitosis / pi3k / other / rtk / jnk_p38 / other / other / rtk / cell_cyc / pi3k / erk_mapk / mitosis / other / rtk / igfr 22_21127217_C_G 16 RHBDD2_2 326_GSK690693_3 / 283_Omipalisib_2 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 304_SB52334_3 / 185_Linsitinib_2 / 310_YM201636_3 / 223_ZSTK474_2 / 299__JI-027- 1_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 226_GSK1070916_2 / 302_PI-103_3 / 344_THZ-2-49_3 / 219_AT-7519_2 / 245_UNC0638_3 / 330_XMD13-2_3 / 225_Genentech Cpd 10_3 / 289 pi3k / pi3k / other / mitosis / pi3k / rtk / igfr / other / pi3k / tor / other / other / cell_cyc / other / mitosis / mitosis / pi3k / cell_cyc / cell_cyc / chromatin / other / mitosis / other 1_26457907_T_G / 22_30937565_T_G 17 NELL2_2 281_Alectinib_2 / 310_YM201636_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 276_CAY10603_3 / 273_CUDC-101_2 / 260_3_ / 346_THZ-2-102-1_3 / 303_PIK-93_3 / 290_KIN001-260_3 / 305_TPCA-1_3 / 272_AR-42_2 / 222_BX-912_3 / 256_JW-7-24-1_3 / 298_OSI-930_2 / 223_ZSTK474_2 rtk / other / cell_cyc / mitosis / mitosis / other / pi3k / chromatin / chromatin / mitosis / chromatin / other / chromatin / erk_mapk / cell_cyc / pi3k / other / other / chromatin / pi3k / other / rtk / pi3k 1_26457907_T_G / 5_141432375_A_C 18 LIPI_3_23 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 298_OSI-930_2 / 256_TP-24 288_WHI-P97_3 / 290_KIN001-260_3 / 326_GSK690693_3 / 341_Selisistat_3 / 1259_Talazoparib_3 / 271_VNLG / 124_3 / 292_Masitinib_1 / 303_PIK-93_3 / 221_TAK-715_2 / 301_HA_ erk_mapk / other / cell_cyc / mitosis / other / rtk / pi3k / other / rtk / other / other / other / other / other / pi3k / other / g_integrity / chromatin / rtk / pi3k / jnk_p38 / cell_cyc / rtk 1_26457907_T_G / 5_141432375_A_C / 15_25177023_G_C 19 RUNX1_1 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 211_TL-2-105_3 / 253_XMD14-99_3 / 305_TPCA-1_3 / 225_Genentech Cpd 10_3 715_2 / 223_ZSTK474_2 / 330_XMD13-2_3 / 303_PIK-93_3 / 326_GSK690693_3 / 136_Mitomycin-C_1 / 304_SB52334_3 / 301_PHA-793887_3 / 254_Quizartinib_2 / 252_WZ3105_3 / 346TH erk_mapk / other / pi3k / mitosis / other / erk_mapk / rtk / other / mitosis / cell_cyc / mitosis / pi3k / jnk_p38 / pi3k / other / pi3k / pi3k / DNArep / rtk / cell_cyc / rtk / other / cell_cyc 1_26457907_T_G 20 UGT3A2_1 310_YM201636_3 / 263_FR-180204_3 / 305_TPCA-1_3 / 252_WZ3105_3 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3_3 / 3_3_2 / 399 152_CP466722_3 / 283_Omipalisib_2 / 271_VNLG / 124_3 / 288_WHI-P97_3 / 1259_Talazoparib_3 / 286_KIN001-236_3 / 326_GSK690693_3 / 331_QL-X-138_3 / 223_ZSTK474_2 / 253_290 other / erk_mapk / other / other / rtk / mitosis / cell_cyc / pi3k / pi3k / tor / other / other / g_integrity / pi3k / chromatin / other / g_integrity / other / pi3k / other / pi3k / rtk / other 1_26457907_T_G 21 SLAIN1_2 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 281_Alectinib_2 / 226_GSK1070916_2 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 326_GSK690693_2_3_Z2_Z 305_TPCA-1_3 / 303_PIK-93_3 / 225_Genentech Cpd 10_3 / 346_THZ-2-102-1_3 / 152_CP466722_3 / 222_BX-912_3 other / pi3k / erk_mapk / rtk / mitosis / other / mitosis / other / pi3k / cell_cyc / pi3k / other / pi3k / tor / other / pi3k / mitosis / cell_cyc / g_integrity / pi3k 1_26457907_T_G / 22_21127217_C_G 22 TRPM4_3 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 283_Omipalisib_2 / 330_XMD13-2_3 / 1495_Olaparib_1 / 305_TPCA-1_3 / 304_SB52334_3 / 226_GSK1070916_2 / 257_NPK76-II-72-1_3 / 326_GSK690693_3 / 346_THZ-2-102-1_3 / 253_XMD14-99_3 / 271_VNLG / 124_3 erk_mapk / other / cell_cyc / other / mitosis / other / g_integrity / pi3k / pi3k / pi3k / other / g_integrity / other / rtk / mitosis / mitosis / pi3k / cell_cyc / rtk / chromatin 1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G 23 SLC24A3_1 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 271_VNLG / 124_3 / 286_KIN001-236_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 253_XMD14-99_3 / 205_Avagacestat_2 / 281_Alectinib_2 / 326_GSK690693_3 / 256_JW-7-24-1_3 / 304_SB52334_3 / 298_OSI- 930_2 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 288_WHI-P97_3 / 1495_Olaparib_1 erk_mapk / other / cell_cyc / chromatin / other / g_integrity / pi3k / other / rtk / other / rtk / pi3k / other / rtk / rtk / mitosis / pi3k / other / other / g_integrity 22_22643666_C_G 24 NCKAP1L_1 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 256_JW-7-24-1_3 / 326_GSK690693_3 / 299_OSI-027_2 / 223_ZSTK474_2 / 304_SB52334_3_3 344_THZ-2-49_3 / 152_CP466722_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 271_VNLG / 124_3 / 226_GSK1070916_2 erk_mapk / other / pi3k / other / other / pi3k / tor / pi3k / rtk / other / pi3k / g_integrity / mitosis / other / cell_cyc / g_integrity / pi3k / other / chromatin / mitosis 1_26457907_T_G 25 RAB32_3 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 326_GSK690693_3 / 252_WZ3105_3 / 222_BX-912_3 / 226_GSK1070916_2 / 290_KIN001-260_3 / 305_TPCA-1_3 7-24-1_3 / 303_PIK-93_3 / 346_THZ-2-102-1_3 / 152_CP466722_3 / 254_Quizartinib_2 / 283_Omipalisib_2 mitosis / pi3k / other / pi3k / other / pi3k / mitosis / other / other / other / mitosis / erk_mapk / rtk / other / pi3k / cell_cyc / g_integrity / rtk / pi3k 1_26457907_T_G / 15_92992967_C_T / 5_141477711_A_G 26 E2F5_1 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 253_XMD14-99_3 / 326_GSK690693_3 / 305_TPCA-1_3 / 226_GSK1070916_2 / 283_Omipalisib_2 / 290_KIN001-260_3 / 211_TL-2-105_3 / 304_SB52334_3 / 252_WZ3105_3 / 303_PIK-93_3 / 221_TAK- 715_2 / 265_Tubastatin A_3 / 223_ZSTK474_2 / 257_NPK76-II-72-1_3 / 330_XMD13-2_3 erk_mapk / other / mitosis / pi3k / rtk / pi3k / other / mitosis / pi3k / other / erk_mapk / rtk / other / pi3k / jnk_p38 / chromatin / pi3k / mitosis / other 8_22080213_T_C 27 RBM11_5 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 226_GSK1070916__3 AZ 93_3 / 223_ZSTK474_2 / 271_VNLG / 124_3 / 253_XMD14-99_3 / 283_Omipalisib_2 other / erk_mapk / cell_cyc / other / other / pi3k / mitosis / rtk / mitosis / pi3k / other / g_integrity / other / pi3k / pi3k / chromatin / rtk / pi3k 1_26457907_T_G / 5_141432375_A_C / 12_52771095_C_G / 8_109483107_T_G / 22_18847351_G_C 28 JHDM1D_1 310_YM201636_3 / 279_BIX02189_3 / 252_WZ3105_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 263_FR-180204_3 / 256_JW-7-24-1_3 / 304_SB52334_3 / 286_KIN001-236_3 / 287_KIN001-244_3 / 223_ZSTK474_2 / 290_KIN001-260_3 / 288_WHI-P97_3 / 299_OSI- 027_2 / 257_NPK76-II-72-1_3 / 253_XMD14-99_3 other / other / other / other / pi3k / pi3k / erk_mapk / other / rtk / other / pi3k / pi3k / other / other / tor / mitosis / rtk 22_21127217_C_G 29 SDC1_2 310_YM201636_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 346_THZ-2-102-1_3 / 211_TL-2-105_3 / 283_Omi305_TP 290_KIN001-260_3 / 326_GSK690693_3 / 344_THZ-2-49_3 / 281_Alectinib_2 / 254_Quizartinib_2 / 263_FR-180204_3 other / other / mitosis / mitosis / pi3k / pi3k / cell_cyc / erk_mapk / pi3k / other / other / other / pi3k / cell_cyc / rtk / rtk / erk_mapk 1_26457907_T_G / 3_52520584_A_C 30 ENPP3_2 344_THZ-2-49_3 / 252_WZ3105_3 / 310_YM201636_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 303_PIK-93_3 / 228_AKT_inhibitor_VIII_3 / 283_Omipalisib_2 / 346_THZ-2-102-1_394_ 1_3 / 326_GSK690693_3 / 281_Alectinib_2 / 331_QL-X-138_3 / 305_TPCA-1_3 cell_cyc / other / other / erk_mapk / other / pi3k / pi3k / pi3k / cell_cyc / mitosis / other / mitosis / pi3k / rtk / other / other 1_26457907_T_G / 22_22643666_C_G 31 RBM33_1 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 252_WZ3105_3 / 290_KIN001-260_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 346_THZ-2-102-1_3 / 305_TPCA-1_3 / 326_GSK690693_3 / 283_Oi 299_OSI-027_2 / 331_QL-X-138_3 / 265_Tubastatin A_3 / 256_JW-7-24-1_3 / 330_XMD13-2_3 mitosis / erk_mapk / other / other / other / cell_cyc / cell_cyc / other / pi3k / pi3k / mitosis / tor / other / chromatin / other / other 1_26457907_T_G 32 MYOM2_1 263_FR-180204_3 / 310_YM201636_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 208_Ispinesib_3_ -930_2 / 306_Fedratinib_2 / 344_THZ-2-49_3 erk_mapk / other / mitosis / mitosis / other / other / pi3k / other / mitosis / pi3k / mitosis / jnk_p38 / other / rtk / other / cell_cyc 1_26457907_T_G 33 ADRB1_1 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 326_GSK690693_3 / 298_OSI-930_2 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 290_KIN001-260_3 / 283_Omipalisib_2 / 185_Linsitinib_2 / 226_GSK1070916_2 / 305_TPCA-1_3 / 286_KIN001- 236_3 / 221_TAK-715_2 erk_mapk / other / cell_cyc / mitosis / other / pi3k / rtk / pi3k / other / other / pi3k / igfr / mitosis / other / other / jnk_p38 1_26457907_T_G 34 FAM19A5_1 310_YM201636_3 / 253_XMD14-99_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 211_TL-2-105_3 / 326_GSK690693_3 / 283_Omipalisib_2 / 254_Quizartinib_2 / 305_TPCA-1_3_3_93_3_3_3_P_P_P_1_3_P_P 24-1_3 / 281_Alectinib_2 / 224_AS605240_3 other / rtk / erk_mapk / pi3k / erk_mapk / pi3k / pi3k / rtk / other / mitosis / pi3k / other / rtk / other / rtk / pi3k 22_22643666_C_G 35 CDK6_2 228_AKT_inhibitor_VIII_3 / 253_XMD14-99_3 / 254_Quizartinib_2 / 211_TL-2-105_3 / 283_Omipalisib_2 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 223_ZSTK474_2 / 224_AS605240_3 / 306_Fedratinib_2 / 263_FR-180204_3 / 305_TPCA-1_3 / 282_Pelitinib_2 / 225_Genentech Cpd 10_3 / 281_Alectinib_2 / 221_TAK- 715_2 pi3k / rtk / rtk / erk_mapk / pi3k / mitosis / other / pi3k / pi3k / other / erk_mapk / other / egfr / mitosis / rtk / jnk_p38 6_31662176_A_G / 6_31662464_C_T 36 C1orf54_1 221_TAK-715_2 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 310_YM201636_3 / 341_Selisistat_3 / 298_OSI-930_2 / 330_XMD13-2_3 / 286_KIN001-236_3 / 346_THZ-2-102-1_3 / NG 92_3 / 345_KIN001-270_3 / 292_Masitinib_1 jnk_p38 / pi3k / erk_mapk / other / other / rtk / other / other / cell_cyc / other / DNArep / mitosis / other / rtk / cell_cyc / rtk 8_22080213_T_C 37 HOOK1_1 263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 1259_Talazoparib_3 / 271_VNLG / 124_3 / 330_XMD13-2_3 / 304_S_252 -1_3 / 1495_Olaparib_1 erk_mapk / cell_cyc / other / other / mitosis / g_integrity / chromatin / other / rtk / pi3k / pi3k / mitosis / tor / mitosis / other / g_integrity 1_26457907_T_G 38 EVI2A_1 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 221_TAK-715_2 / 283_Omipalisib_2 / 179_5-Fluorouracil_1 / 326_GSK690693_3 / 253_XMD14-99_3 / 330_XMD13-2_3 / 223_ZSTK474_2 / 238_Idelalisib_1 / 136_Mitomycin-C_1 / 305_TPCA-1_3 pi3k / mitosis / other / mitosis / erk_mapk / jnk_p38 / pi3k / DNArep / pi3k / rtk / other / pi3k / pi3k / DNArep / other 1_26457907_T_G 39 KDSR_1 310_YM201636_3 / 303_PIK-93_3 / 346_THZ-2-102-1_3 / 263_FR-180204_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 287_KIN001-244_3 / 344_3 / 4344 328_SNX-2112_3 / 304_SB52334_3 / 330_XMD13-2_3 / 271_VNLG / 124_3 / 1259_Talazoparib_3 other / pi3k / cell_cyc / erk_mapk / other / mitosis / other / mitosis / pi3k / cell_cyc / other / rtk / other / chromatin / g_integrity 22_21127217_C_G 40 TRIM69_1 310_YM201636_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 136_Mitomycin-C_1 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 287_KIN001-244_3 / 328_SN_112_3 027_2 / 257_NPK76-II-72-1_3 / 263_FR-180204_3 / 1018_Veliparib_2 other / mitosis / other / DNArep / DNArep / other / other / pi3k / pi3k / other / cell_cyc / tor / mitosis / erk_mapk / g_integrity 22_21127217_C_G 41 FAM69A_1 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 1017_Olaparib_2 / 303_PIK-93_3 / 326_GSK690693_3 / 257_NPK76-II-72-1_3 / 304_SB52334_3 / 290_290_290 346_THZ-2-102-1_3 / 208_Ispinesib Mesylate_2 other / mitosis / other / erk_mapk / g_integrity / pi3k / pi3k / mitosis / rtk / cell_cyc / rtk / other / mitosis / cell_cyc / mitosis 4_105679196_A_C 42 MCF2_1 310_YM201636_3 / 344_THZ-2-49_3 / 290_KIN001-260_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 276_CAY10603_3 / 263_FR-180204_3 / 221_TAK-715_2 / 1259_Talazrib 99_3 / 273_CUDC-101_2 / 228_AKT_inhibitor_VIII_3 other / cell_cyc / other / mitosis / mitosis / other / chromatin / erk_mapk / jnk_p38 / g_integrity / mitosis / chromatin / rtk / chromatin / pi3k 15_42142087_A_C 43 DNMT3A_1 263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 286_KIN001-236_3 / 294_MPS-1-IN-1_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 288_WHI-P97_3 / 290_K__3_Cana / 260_K 1091_BMS-536924_3 erk_mapk / cell_cyc / other / other / mitosis / g_integrity / pi3k / other / other / DNArep / pi3k / other / rtk / other / igfr 1_26457907_T_G 44 RAP1GAP_1 226_GSK1070916_2 / 310_YM201636_3 / 263_FR-180204_3 / 257_NPK76-II-72-1_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 326_GSK690693_3 / 260 288_WHI-P97_3 / 299_OSI-027_2 mitosis / other / erk_mapk / mitosis / other / cell_cyc / mitosis / pi3k / pi3k / other / other / other / other / tor 1_26457907_T_G 45 GCNT1_2 221_TAK-715_2 / 330_XMD13-2_3 / 292_Masitinib_1 / 310_YM201636_3 / 208_Ispinesib Mesylate_2 / 301_PHA-793887_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 253_XT_inhibitor_VIII_3 / 253_XMD_ jnk_p38 / other / rtk / other / mitosis / cell_cyc / g_integrity / pi3k / rtk / other / rtk / erk_mapk / cell_cyc / mitosis 22_22643666_C_G / 1_26457907_T_G 46 ACVR2B_1 228_AKT_inhibitor_VIII_3 / 221_TAK-715_2 / 298_OSI-930_2 / 226_GSK1070916_2 / 330_XMD13-2_3 / 283_Omipalisib_2 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 290 pi3k / jnk_p38 / rtk / mitosis / other / pi3k / mitosis / other / rtk / pi3k / erk_mapk / mitosis / mitosis / rtk 20_10639627_G_A 47 FLII_1 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 257_NPK76-II-72-1_3 / 263_FR-180204_3 / 226_GSK1070916_2 / 265_Tubastatin A_3 / 208_Ispinesib Me3late 236_3 / 252_WZ3105_3 / 305_TPCA-1_3 mitosis / other / cell_cyc / other / mitosis / erk_mapk / mitosis / chromatin / mitosis / other / other / other / other / other 3_52520584_A_C 48 TGS1_1 326_GSK690693_3 / 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 281_Alectinib_2 / 330_XMD13-2_3_ _ 24-1_3 / 279_BIX02189_3 pi3k / erk_mapk / other / mitosis / mitosis / pi3k / other / rtk / other / mitosis / rtk / pi3k / other / other 12_52771095_C_G 49 XG_2 310_YM201636_3 / 288_WHI-P97_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 304_SB52334_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 303_P_I3_93_93 027_2 other / other / other / erk_mapk / mitosis / other / rtk / cell_cyc / other / pi3k / pi3k / other / tor 22_21127217_C_G / 1_26457907_T_G 50 PCDH17_2 344_THZ-2-49_3 / 281_Alectinib_2 / 252_WZ3105_3 / 330_XMD13-2_3 / 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 283_Omipalisib_2 / 256_JW-7-24-1_3 / 326_G_S3 _ cell_cyc / rtk / other / other / other / erk_mapk / mitosis / pi3k / other / pi3k / mitosis / pi3k / pi3k 1_26457907_T_G / 5_141432375_A_C 51 FCGRT_4 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 252_WZ3105_3 / 1259_Talazoparib_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3_3 II-72-1_3 other / erk_mapk / cell_cyc / mitosis / other / g_integrity / pi3k / other / pi3k / other / pi3k / cell_cyc / mitosis 1_26457907_T_G / 22_22643666_C_G / 5_141432375_A_C / 22_21127217_C_G 52 PPAPDC2_5 263_FR-180204_3 / 310_YM201636_3 / 1259_Talazoparib_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 305_TPCA-1_3 / 288_WHI-P97_3 / 286_KIN001-236_3 / 228_AKT_inhibitor_V__300_3_3 erk_mapk / other / g_integrity / mitosis / cell_cyc / other / other / other / pi3k / DNArep / other / pi3k / other 1_26457907_T_G / 15_42142087_A_C / 19_3179506_A_C / 8_22080213_T_C / 22_22643666_C_G 53 OTUD1_1 310_YM201636_3 / 252_WZ3105_3 / 306_Fedratinib_2 / 263_FR-180204_3 / 256_JW-7-24-1_3 / 254_Quizartinib_2 / 304_SB52334_3 / 228_AKT_inhibitor_VIII_3 / 305_TPCA-1_3 / 270_N_P_C3 / 290 other / other / other / erk_mapk / other / rtk / rtk / pi3k / other / other / mitosis / egfr / chromatin 3_128992964_T_G 54 IRS2_2 344_THZ-2-49_3 / 310_YM201636_3 / 263_FR-180204_3 / 303_PIK-93_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 257_NPK76-II-72-1_3 / 330_XMD13-2_3 / 305 -3 102-1_3 cell_cyc / other / erk_mapk / pi3k / other / mitosis / pi3k / mitosis / other / other / rtk / cell_cyc 1_26457907_T_G / 22_22643666_C_G 55 AKAP7_1 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 290_KIN001-260_3 / 305_TPCA-1_2_I_2_I_2_I2_29 erk_mapk / other / mitosis / cell_cyc / other / pi3k / other / other / other / rtk / mitosis / tor 1_26457907_T_G 56 PCMTD2_1 304_SB52334_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 283_Omipalisib_2 / 263_FR-180204_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3 / 136_Mitomycin-C_1 / 252_WZ3105_3 rtk / mitosis / other / pi3k / erk_mapk / other / pi3k / DNArep / other / g_integrity / pi3k / other 1_26457907_T_G 57 ANXA11_1 305_TPCA-1_3 / 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 279_BIX02189_3 / 257_NPK76-II-72-1_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 253_X_ other / other / erk_mapk / mitosis / other / mitosis / pi3k / pi3k / rtk / rtk / other / other 1_26457907_T_G 58 CYP4F22_1 310_YM201636_3 / 330_XMD13-2_3 / 211_TL-2-105_3 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 226_GSK1070916_2 / 294_MPS-1-_3_3_3_39_3 / 3_39 other / other / erk_mapk / pi3k / erk_mapk / other / mitosis / mitosis / mitosis / cell_cyc / pi3k / other 22_21127217_C_G 59 FAH_1 344_THZ-2-49_3 / 257_NPK76-II-72-1_3 / 310_YM201636_3 / 263_FR-180204_3 / 288_WHI-P97_3 / 290_KIN001-260_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 252_WZ3105_3_93_93_93K 330_XMD13-2_3 cell_cyc / mitosis / other / erk_mapk / other / other / mitosis / other / other / pi3k / other / other 22_22643666_C_G 60 PRSS35_1 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 288_WHI-P97_3 / 252_WZ3105_3 / 330_XMD13-2_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 305_TPCA-1_3_Travel 100_ erk_mapk / other / pi3k / other / other / other / mitosis / cell_cyc / other / other / DNArep / g_integrity 1_26457907_T_G 61 ARID2_1 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 226_GSK1070916_2 / 344_THZ-2-49_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_II-305 erk_mapk / other / mitosis / other / mitosis / cell_cyc / pi3k / pi3k / other / other / mitosis 1_26457907_T_G 62 GBE1_2 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3 / 283_Omipalisib_2 / 226_GSK1070916_2 / 136_Mitomycin-C_1 / 330_XMD13-2_3 / 304_S3 erk_mapk / mitosis / other / other / pi3k / pi3k / mitosis / DNArep / other / rtk / pi3k 1_26457907_T_G / 22_22643666_C_G 63 FEZF1_2 310_YM201636_3 / 263_FR-180204_3 / 252_WZ3105_3 / 1259_Talazoparib_3 / 326_GSK690693_3 / 330_XMD13-2_3 / 226_GSK1070916_2 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 228_VT_information other / erk_mapk / other / g_integrity / pi3k / other / mitosis / cell_cyc / mitosis / pi3k / other 1_26457907_T_G / 22_22643666_C_G 64 ACACB_2 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 283_Omipalisib_2 / 263_FR-180204_3 / 1008_Methotrexate_1 / 252_WZ3105_3 / 326_GSK690693_3 / 222_BX-912_3_303 pi3k / other / mitosis / pi3k / erk_mapk / DNArep / other / pi3k / pi3k / pi3k / rtk 1_26457907_T_G / 22_18847351_G_C 65 CUX2_1 330_XMD13-2_3 / 310_YM201636_3 / 299_OSI-027_2 / 304_SB52334_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 283_Omipalisib_2 / 331_QL-X-138_3 / 326_GSK690693_3 / 228_AKT_inhibitor other / other / tor / rtk / other / erk_mapk / pi3k / other / pi3k / pi3k / mitosis 22_21127217_C_G 66 H2AFY2_1 1259_Talazoparib_3 / 263_FR-180204_3 / 310_YM201636_3 / 1495_Olaparib_1 / 136_Mitomycin-C_1 / 330_XMD13-2_3 / 271_VNLG / 124_3 / 344_THZ-2-49_3 / 221_TAK-715_2 / 226_G941070916-1- g_integrity / erk_mapk / other / g_integrity / DNArep / other / chromatin / cell_cyc / jnk_p38 / mitosis / mitosis 22_22643666_C_G 67 SCNN1G_1 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 221_TAK-715_2 / 288_WHI-P97_3_39_94_3_94_3_94_ erk_mapk / other / cell_cyc / other / g_integrity / pi3k / other / jnk_p38 / other / mitosis / pi3k 1_26457907_T_G 68 MICAL2_1 228_AKT_inhibitor_VIII_3 / 326_GSK690693_3 / 310_YM201636_3 / 283_Omipalisib_2 / 211_TL-2-105_3 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 221_TAK-715_2 / 330_XMD13-2_3 / 254 pi3k / pi3k / other / pi3k / erk_mapk / rtk / mitosis / jnk_p38 / other / erk_mapk / rtk 6_151015603_C_G 69 SWT1_2 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 344_THZ-2-49_3 / 253_XMD14-99_3 / 211_TL-2-105_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 221_TAK-715_2 / 283_Omipalisib_2 / 105G other / pi3k / cell_cyc / rtk / erk_mapk / erk_mapk / other / jnk_p38 / pi3k / other / mitosis 1_26457907_T_G / 8_109483107_T_G 70 PDE6B_1 286_KIN001-236_3 / 263_FR-180204_3 / 1259_Talazoparib_3 / 310_YM201636_3 / 298_OSI-930_2 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 206_Ruxolitinib_1 / 1012_Vorinostat13 / 330 other / erk_mapk / g_integrity / other / rtk / pi3k / mitosis / other / chromatin / other / other 15_42142087_A_C 71 FUT11_4 310_YM201636_3 / 288_WHI-P97_3 / 330_XMD13-2_3 / 286_KIN001-236_3 / 291_KIN001-266_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 281_Alectinib_2 / 305_TPCA-1_3-1-94-1 other / other / other / other / other / cell_cyc / pi3k / rtk / other / mitosis 1_26457907_T_G / 22_24252424_G_C / 22_21127217_C_G / 22_22643666_C_G 72 CRMP1_2 299_OSI-027_2 / 310_YM201636_3 / 256_JW-7-24-1_3 / 305_TPCA-1_3 / 274_Belinostat_1 / 263_FR-180204_3 / 276_CAY10603_3 / 330_XMD13-2_3 / 226_GSK1070916_2 / 272_AR-42_2 tor / other / other / other / chromatin / erk_mapk / chromatin / other / mitosis / chromatin 22_21127217_C_G / 1_26457907_T_G 73 ATP2B3_2 281_Alectinib_2 / 310_YM201636_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 / 305_TPCA-1_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 290_K001 rtk / other / other / pi3k / mitosis / mitosis / other / erk_mapk / cell_cyc / other 1_26457907_T_G / 17_7604041_A_C 74 KLHL23_2 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 253_XMD14-99_3 / 281_Alectinib_2 / 304_SB52334_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 326_SK3 erk_mapk / mitosis / pi3k / other / rtk / rtk / rtk / other / igfr / pi3k 1_26457907_T_G / 5_141432375_A_C 75 PNMAL1_1 310_YM201636_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 344_THZ-2-49_3 / 346_THZ-2-102-1_3 / 283_Omipalisib_2 / 261_TL-1-85_3 / 228_AK other / mitosis / mitosis / pi3k / other / cell_cyc / cell_cyc / pi3k / other / pi3k 1_26457907_T_G 76 DPP9_1 263_FR-180204_3 / 1008_Methotrexate_1 / 185_Linsitinib_2 / 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 305_TPCA-1_3 / 304_SB52334_3 / 326_G690 erk_mapk / DNArep / igfr / pi3k / mitosis / mitosis / other / other / rtk / pi3k 22_21127217_C_G 77 GPC2_1 228_AKT_inhibitor_VIII_3 / 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 263_FR-180204_3 / 310_YM201636_3 / 330_XMD13-2_3 / 283_Omipalisib_2 / 226_GSK10709163 / 252_3 pi3k / igfr / mitosis / pi3k / erk_mapk / other / other / pi3k / mitosis / other 5_141432375_A_C 78 RBM27_1 330_XMD13-2_3 / 265_Tubastatin A_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 271_VNLG / 124_3 / 326_GSK690693_3 / 273_CUDC-101_2 / 226_GSK1070916_2 / 310_YM201636_3 / 263_FR-204 other / chromatin / cell_cyc / mitosis / chromatin / pi3k / chromatin / mitosis / other / erk_mapk 19_48617887_T_G 79 HOXD13_1 344_THZ-2-49_3 / 263_FR-180204_3 / 298_OSI-930_2 / 1248_Daporinad_3 / 1259_Talazoparib_3 / 1091_BMS-536924_3 / 310_YM201636_3 / 136_Mitomycin-C_1 / 326_GSK690693_3 / 294_MPS-1-IN cell_cyc / erk_mapk / rtk / metabol / g_integrity / igfr / other / DNArep / pi3k / mitosis 1_26457907_T_G 80 TFCP2_1 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 326_GSK690693_3 / 281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 252_WZ3105_3 / 298_OSI-930_2 / 330_MD mitosis / mitosis / erk_mapk / pi3k / rtk / pi3k / other / other / rtk / other 19_55796171_G_T 81 MLC1_2 310_YM201636_3 / 1011_Navitoclax_2 / 344_THZ-2-49_3 / 263_FR-180204_3 / 303_PIK-93_3 / 288_WHI-P97_3 / 228_AKT_inhibitor_VIII_3 / 346_THZ-2-102-1_3 / 252_WZ3105_3 other / apop / cell_cyc / erk_mapk / pi3k / other / pi3k / cell_cyc / other 1_26457907_T_G / 7_72941936_T_C 82 NUDT10_1 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 326_GSK690693_3 / 283_Omipalisib_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 252_WZ3105_3 / 281_Alectinib_2 other / pi3k / mitosis / pi3k / pi3k / other / mitosis / other / rtk 1_26457907_T_G 83 ABHD6_5 344_THZ-2-49_3 / 310_YM201636_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 273_CUDC-101_2 / 265_Tubastatin A_3 cell_cyc / other / other / pi3k / mitosis / other / mitosis / chromatin / chromatin 12_52771095_C_G / 1_26457907_T_G / 22_18847351_G_C / 5_141432375_A_C / 22_21127217_C_G 84 NDST4_2 310_YM201636_3 / 252_WZ3105_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 283_Omipalisib_2 other / other / erk_mapk / other / cell_cyc / pi3k / mitosis / other / pi3k 1_26457907_T_G / 1_219210601_T_G 85 POU3F2_5 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 226_GSK1070916_2 / 330_XMD13-2_3 / 263_FR-180204_3 / 346_THZ-2-102-1_3 / 257_NPK76-II-72-1_3 / 281_Alectinib_2 cell_cyc / other / other / mitosis / other / erk_mapk / cell_cyc / mitosis / rtk 1_26457907_T_G / 5_141432375_A_C / 1_219210601_T_G / 1_205381583_C_G / 3_52520584_A_C 86 RND2_1 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 305_TPCA-1_3 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 221_TAK-715_2 / 253_XMD14-99_3 erk_mapk / pi3k / other / other / rtk / mitosis / other / jnk_p38 / rtk 1_26457907_T_G 87 TEKT2_1 263_FR-180204_3 / 185_Linsitinib_2 / 344_THZ-2-49_3 / 252_WZ3105_3 / 310_YM201636_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 271_VNLG / 124_3 erk_mapk / igfr / cell_cyc / other / other / pi3k / pi3k / mitosis / chromatin 1_26457907_T_G 88 RCOR1_1 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 330_XMD13-2_ erk_mapk / other / mitosis / cell_cyc / mitosis / pi3k / other / mitosis / other 1_176702776_TGAGAGAGA_T 89 SH3GLB1_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 1264_SGC0946_3 / 253_XMD14-99_3 / 265_Tubastatin A_3 / 305_TPCA-1_3 / 290_KIN001-260_3 / 228_AKT_inhibitor_VIII_3 erk_mapk / mitosis / other / chromatin / rtk / chromatin / other / other / pi3k 22_22643666_C_G 90 ZCCHC5_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 283_Omipalisib_2 / 300_CX-5461_3 / 136_Mitomycin-C_1 / 208_Ispinesib Mesylate_2 / 299_OSI-027_2 / 302_PI-103_3 / 151_QS11_3 mitosis / DNArep / pi3k / other / DNArep / mitosis / tor / pi3k / other 22_22643666_C_G 91 EVI2B_1 310_YM201636_3 / 326_GSK690693_3 / 1259_Talazoparib_3 / 226_GSK1070916_2 / 298_OSI-930_2 / 228_AKT_inhibitor_VIII_3 / 136_Mitomycin-C_1 / 344_THZ-2-49_3 / 211_TL-2-105_3 other / pi3k / g_integrity / mitosis / rtk / pi3k / DNArep / cell_cyc / erk_mapk 10_46462341_C_A 92 EPC1_2 310_YM201636_3 / 263_FR-180204_3 / 1259_Talazoparib_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 303_PIK-93_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 226_GSK1070916_2 other / erk_mapk / g_integrity / other / other / pi3k / mitosis / other / mitosis 19_6744459_C_G / 19_42723940_A_C 93 VAX1_2 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 other / erk_mapk / cell_cyc / pi3k / pi3k / other / mitosis / mitosis 1_26457907_T_G / 22_21127217_C_G 94 DLG2_3 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 344_THZ-2-49_3 / 185_Linsitinib_2 / 304_SB52334_3 / 305_TPCA-1_3 erk_mapk / other / mitosis / pi3k / cell_cyc / igfr / rtk / other 22_21127217_C_G / 22_18847351_G_C / 1_26457907_T_G 95 PPP1R1A_2 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 326_GSK690693_3 / 294_MPS-1-IN-1_3 other / erk_mapk / cell_cyc / pi3k / other / other / pi3k / mitosis 1_26457907_T_G / 5_141432375_A_C 96 EFNB1_1 344_THZ-2-49_3 / 252_WZ3105_3 / 310_YM201636_3 / 256_JW-7-24-1_3 / 263_FR-180204_3 / 299_OSI-027_2 / 330_XMD13-2_3 / 281_Alectinib_2 cell_cyc / other / other / other / erk_mapk / tor / other / rtk 1_26457907_T_G 97 POU3F1_2 263_FR-180204_3 / 310_YM201636_3 / 1259_Talazoparib_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 erk_mapk / other / g_integrity / mitosis / mitosis / pi3k / other / pi3k 1_26457907_T_G / 22_22643666_C_G 98 JPH1_2 263_FR-180204_3 / 344_THZ-2-49_3 / 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 310_YM201636_3 / 252_WZ3105_3 / 298_OSI-930_2 erk_mapk / cell_cyc / igfr / mitosis / pi3k / other / other / rtk 1_26457907_T_G / 19_32643405_T_C 99 LGALS3_5 281_Alectinib_2 / 330_XMD13-2_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 326_GSK690693_3 / 252_WZ3105_3 / 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 rtk / other / other / cell_cyc / pi3k / other / mitosis / pi3k 1_26457907_T_G / 5_141432375_A_C / 3_51333222_A_C / 7_100760409_A_C / 22_24252424_G_C 100 LRRC4B_1 310_YM201636_3 / 303_PIK-93_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 305_TPCA-1_3 / 283_Omipalisib_2 / 346_THZ-2-102-1_3 / 226_GSK1070916_2 other / pi3k / erk_mapk / pi3k / other / pi3k / cell_cyc / mitosis 22_21127217_C_G 101 ARHGAP19_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 221_TAK-715_2 / 330_XMD13-2_3 / 305_TPCA-1_3 / 226_GSK1070916_2 erk_mapk / mitosis / other / pi3k / jnk_p38 / other / other / mitosis 22_22643666_C_G 102 MYL9_1 310_YM201636_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 263_FR-180204_3 other / other / cell_cyc / mitosis / mitosis / pi3k / erk_mapk 1_26457907_T_G 103 TMEM170B_1 294_MPS-1-IN-1_3 / 310_YM201636_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 281_Alectinib_2 / 305_TPCA-1_3 / 326_GSK690693_3 mitosis / other / erk_mapk / pi3k / rtk / other / pi3k 1_26457907_T_G 104 CSAD_1 326_GSK690693_3 / 283_Omipalisib_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 pi3k / pi3k / other / mitosis / mitosis / pi3k / other 1_26457907_T_G 105 ASGR1_5 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 288_WHI-P97_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 erk_mapk / other / cell_cyc / other / pi3k / mitosis / other 22_22643666_C_G / 1_26457907_T_G / 15_42142087_A_C / 22_21127217_C_G / 5_141432375_A_C 106 KIAA1958_1 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 223_ZSTK474_2 / 226_GSK1070916_2 / 305_TPCA-1_3 other / erk_mapk / mitosis / pi3k / pi3k / mitosis / other 1_26457907_T_G 107 NPW_2 310_YM201636_3 / 344_THZ-2-49_3 / 263_FR-180204_3 / 226_GSK1070916_2 / 288_WHI-P97_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3 other / cell_cyc / erk_mapk / mitosis / other / other / pi3k 1_26457907_T_G / 3_52520584_A_C 108 CAP1_1 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 290_KIN001-260_3 / 136_Mitomycin-C_1 / 286_KIN001-236_3 erk_mapk / other / mitosis / other / other / DNArep / other 1_26457907_T_G 109 SIAH3_1 344_THZ-2-49_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 286_KIN001-236_3 / 253_XMD14-99_3 cell_cyc / other / mitosis / other / erk_mapk / other / rtk 1_26457907_T_G 110 PALM3_1 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 283_Omipalisib_2 / 271_VNLG / 124_3 / 304_SB52334_3 erk_mapk / pi3k / mitosis / pi3k / pi3k / chromatin / rtk 22_22643666_C_G 111 STMN3_1 303_PIK-93_3 / 260_NG-25_3 / 300_CX-5461_3 / 287_KIN001-244_3 / 305_TPCA-1_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 pi3k / other / other / pi3k / other / other / mitosis 6_110102054_T_G 112 TMEM81_1 263_FR-180204_3 / 344_THZ-2-49_3 / 326_GSK690693_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 226_GSK1070916_2 erk_mapk / cell_cyc / pi3k / other / mitosis / other / mitosis 19_7056560_G_T 113 SPATA6L_2 263_FR-180204_3 / 1259_Talazoparib_3 / 310_YM201636_3 / 271_VNLG / 124_3 / 286_KIN001-236_3 / 304_SB52334_3 / 1008_Methotrexate_1 erk_mapk / g_integrity / other / chromatin / other / rtk / DNArep 8_1678462_A_C / 1_26457907_T_G 114 CSRP2BP_5 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 257_NPK76-II-72-1_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 326_GSK690693_3 pi3k / other / cell_cyc / mitosis / mitosis / erk_mapk / pi3k 1_26457907_T_G / 17_65225089_T_C / 1_205381583_C_G / 17_7318141_T_G / 16_22266423_T_C 115 MAP2K6_1 228_AKT_inhibitor_VIII_3 / 221_TAK-715_2 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 253_XMD14-99_3 / 310_YM201636_3 pi3k / jnk_p38 / erk_mapk / mitosis / other / rtk / other 6_151015603_C_G 116 HOXB13_1 263_FR-180204_3 / 1008_Methotrexate_1 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 1259_Talazoparib_3 / 286_KIN001-236_3 erk_mapk / DNArep / mitosis / other / pi3k / g_integrity / other 1_26457907_T_G 117 RBM12B_1 326_GSK690693_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 290_KIN001-260_3 / 253_XMD14-99_3 / 305_TPCA-1_3 pi3k / mitosis / rtk / erk_mapk / other / rtk / other 8_131984112_C_T 118 ADRB3_1 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 erk_mapk / other / cell_cyc / pi3k / mitosis / other 1_26457907_T_G 119 LUC7L_5 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 326_GSK690693_3 erk_mapk / pi3k / other / mitosis / rtk / pi3k 1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G / 15_50544697_C_A / 5_141432375_A_C 120 ITM2A_1 344_THZ-2-49_3 / 263_FR-180204_3 / 310_YM201636_3 / 252_WZ3105_3 / 330_XMD13-2_3 / 256_JW-7-24-1_3 cell_cyc / erk_mapk / other / other / other / other 1_26457907_T_G 121 ICAM4_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 298_OSI-930_2 / 344_THZ-2-49_3 erk_mapk / mitosis / other / pi3k / rtk / cell_cyc 1_26457907_T_G 122 HMCN1_1 310_YM201636_3 / 252_WZ3105_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 283_Omipalisib_2 / 344_THZ-2-49_3 other / other / erk_mapk / pi3k / pi3k / cell_cyc 1_26457907_T_G 123 ZNF397_4 310_YM201636_3 / 276_CAY10603_3 / 245_UNC0638_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 303_PIK-93_3 other / chromatin / chromatin / mitosis / erk_mapk / pi3k 22_22643666_C_G / 22_21127217_C_G / 15_56693096_A_C / 1_26457907_T_G 124 DRAP1_1 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 290_KIN001-260_3 other / mitosis / erk_mapk / other / pi3k / other 1_26457907_T_G 125 DTX3L_1 305_TPCA-1_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 257_NPK76-II-72-1_3 / 290_KIN001-260_3 other / other / mitosis / erk_mapk / mitosis / other 1_26457907_T_G 126 NUDT11_5 310_YM201636_3 / 281_Alectinib_2 / 344_THZ-2-49_3 / 257_NPK76-II-72-1_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 other / rtk / cell_cyc / mitosis / other / mitosis 1_26457907_T_G / 5_141432375_A_C / 12_52771095_C_G / 1_219210601_T_G / 22_18847351_G_C 127 ADAM19_3 265_Tubastatin A_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 310_YM201636_3 / 271_VNLG / 124_3 chromatin / erk_mapk / mitosis / other / other / chromatin 22_21127217_C_G / 22_21283300_G_C / 14_68882917_A_G 128 HS3ST4_2 263_FR-180204_3 / 310_YM201636_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 erk_mapk / other / pi3k / pi3k / other / cell_cyc 1_26457907_T_G / 12_52771095_C_G 129 CRIPAK_4 346_THZ-2-102-1_3 / 261_TL-1-85_3 / 303_PIK-93_3 / 287_KIN001-244_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 cell_cyc / other / pi3k / pi3k / mitosis / other 9_137101572_A_C / 4_48557504_A_G / 6_160247199_T_G / 7_44697564_T_G 130 OLFM3_1 263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 298_OSI-930_2 erk_mapk / cell_cyc / other / other / other / rtk 22_22643666_C_G 131 LMO2_4 344_THZ-2-49_3 / 263_FR-180204_3 / 281_Alectinib_2 / 310_YM201636_3 / 1259_Talazoparib_3 / 252_WZ3105_3 cell_cyc / erk_mapk / rtk / other / g_integrity / other 5_141432375_A_C / 1_26457907_T_G / 11_1246628_A_C / 15_25177023_G_C 132 SALL2_1 263_FR-180204_3 / 1008_Methotrexate_1 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 erk_mapk / DNArep / other / mitosis / g_integrity / pi3k 22_22643666_C_G 133 SLC35F3_1 1495_Olaparib_1 / 330_XMD13-2_3 / 1259_Talazoparib_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 310_YM201636_3 g_integrity / other / g_integrity / cell_cyc / other / other 15_42142087_A_C 134 RHOH_1 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 344_THZ-2-49_3 / 305_TPCA-1_3 other / erk_mapk / mitosis / other / cell_cyc / other 22_21127217_C_G 135 MED23_1 344_THZ-2-49_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 265_Tubastatin A_3 / 310_YM201636_3 / 290_KIN001-260_3 cell_cyc / erk_mapk / mitosis / chromatin / other / other 15_42142087_A_C 136 ALS2CR8_2 310_YM201636_3 / 271_VNLG / 124_3 / 228_AKT_inhibitor_VIII_3 / 1259_Talazoparib_3 / 326_GSK690693_3 / 283_Omipalisib_2 other / chromatin / pi3k / g_integrity / pi3k / pi3k 7_5300364_T_G / 11_64118302_A_C 137 PDS5B_1 226_GSK1070916_2 / 281_Alectinib_2 / 253_XMD14-99_3 / 228_AKT_inhibitor_VIII_3 / 326_GSK690693_3 / 263_FR-180204_3 mitosis / rtk / rtk / pi3k / pi3k / erk_mapk 19_5654163_A_C 138 POU4F1_1 252_WZ3105_3 / 310_YM201636_3 / 226_GSK1070916_2 / 344_THZ-2-49_3 / 222_BX-912_3 / 330_XMD13-2_3 other / other / mitosis / cell_cyc / pi3k / other X_149503442_T_G 139 LINGO1_4 263_FR-180204_3 / 310_YM201636_3 / 305_TPCA-1_3 / 288_WHI-P97_3 / 294_MPS-1-IN-1_3 erk_mapk / other / other / other / mitosis 22_22643666_C_G / 22_21127217_C_G / 1_26457907_T_G / 11_66624536_A_C 140 EZH2_2 310_YM201636_3 / 326_GSK690693_3 / 294_MPS-1-IN-1_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3 other / pi3k / mitosis / other / pi3k 1_26457907_T_G / 22_18847351_G_C 141 ZNF786_5 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 283_Omipalisib_2 / 310_YM201636_3 / 326_GSK690693_3 other / mitosis / pi3k / other / pi3k 1_26457907_T_G / 17_7604041_A_C / 17_78120770_A_C / 22_30937565_T_G / 16_25177910_T_G 142 SLCO5A1_1 263_FR-180204_3 / 310_YM201636_3 / 304_SB52334_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 erk_mapk / other / rtk / other / mitosis 1_26457907_T_G 143 DKK2_1 310_YM201636_3 / 344_THZ-2-49_3 / 263_FR-180204_3 / 299_OSI-027_2 / 294_MPS-1-IN-1_3 other / cell_cyc / erk_mapk / tor / mitosis 1_26457907_T_G 144 ATP11C_1 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 273_CUDC-101_2 / 330_XMD13-2_3 cell_cyc / other / other / chromatin / other 1_26457907_T_G 145 KMO_1 310_YM201636_3 / 263_FR-180204_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 other / erk_mapk / pi3k / other / mitosis 22_21127217_C_G 146 SPOCD1_1 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 253_XMD14-99_3 / 286_KIN001-236_3 erk_mapk / pi3k / other / rtk / other 1_26457907_T_G 147 LMO3_1 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 223_ZSTK474_2 / 252_WZ3105_3 / 211_TL-2-105_3 pi3k / other / pi3k / other / erk_mapk 1_26457907_T_G 148 SUCLG2_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1242_ (5Z) -7-Oxozeaenol_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 erk_mapk / erk_mapk / other / erk_mapk / erk_mapk 3_160423378_C_T 149 CDC42EP3_1 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 305_TPCA-1_3 / 226_GSK1070916_2 mitosis / pi3k / erk_mapk / other / mitosis 22_21283300_G_C 150 VIM_2 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 13_99295007_C_T / 13_99314037_A_G 151 KIAA1456_5 263_FR-180204_3 / 288_WHI-P97_3 / 344_THZ-2-49_3 / 310_YM201636_3 erk_mapk / other / cell_cyc / other 1_26457907_T_G / 22_21127217_C_G / 22_22643666_C_G / 3_52520584_A_C / 15_25177023_G_C 152 ATP1A1_1 344_THZ-2-49_3 / 263_FR-180204_3 / 310_YM201636_3 / 252_WZ3105_3 cell_cyc / erk_mapk / other / other 1_26457907_T_G 153 EFHD2_3 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 310_YM201636_3 erk_mapk / mitosis / other / other 1_26457907_T_G / 19_3179506_A_C / 12_48769033_A_C 154 NPY1R_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 310_YM201636_3 erk_mapk / mitosis / cell_cyc / other 1_26457907_T_G 155 PTPN13_1 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 330_XMD13-2_3 cell_cyc / other / other / other 1_26457907_T_G 156 SOX11_3 344_THZ-2-49_3 / 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 cell_cyc / erk_mapk / other / pi3k 1_26457907_T_G / 22_21127217_C_G / 5_141432375_A_C 157 RAVER2_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 226_GSK1070916_2 erk_mapk / mitosis / other / mitosis 1_26457907_T_G 158 CD44_3 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 erk_mapk / mitosis / pi3k / mitosis 1_149813302_A_C / 1_26457907_T_G / 6_151015603_C_G 159 WIPI1_1 263_FR-180204_3 / 281_Alectinib_2 / 310_YM201636_3 / 305_TPCA-1_3 erk_mapk / rtk / other / other 1_26457907_T_G 160 MEIG1_1 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 344_THZ-2-49_3 / 281_Alectinib_2 other / pi3k / cell_cyc / rtk 5_141636680_A_C 161 ITGAV_1 1526_Refametinib_3 / 1014_Refametinib_2 / 1372_Trametinib_1 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 3_180647255_T_TA 162 WASF1_2 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 305_TPCA-1_3 erk_mapk / mitosis / other / other 22_22643666_C_G / 22_21127217_C_G 163 SEPT5_1 263_FR-180204_3 / 310_YM201636_3 / 304_SB52334_3 / 228_AKT_inhibitor_VIII_3 erk_mapk / other / rtk / pi3k 1_26457907_T_G 164 ZNF703_4 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 304_SB52334_3 erk_mapk / other / cell_cyc / rtk 15_42142087_A_C / 19_3179506_A_C / 22_22643666_C_G / 10_71362188_T_C 165 RCAN1_1 310_YM201636_3 / 1259_Talazoparib_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 other / g_integrity / erk_mapk / pi3k 22_22643666_C_G 166 MEIS1_1 310_YM201636_3 / 344_THZ-2-49_3 / 263_FR-180204_3 / 330_XMD13-2_3 other / cell_cyc / erk_mapk / other 11_1246619_A_C 167 DOCK9_2 1014_Refametinib_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk / erk_mapk 17_80065379_A_G / 2_87800520_G_A 168 MAP2K1_1 301_PHA-793887_3 / 1259_Talazoparib_3 / 263_FR-180204_3 / 330_XMD13-2_3 cell_cyc / g_integrity / erk_mapk / other 22_21127217_C_G 169 BAZ2A_1 263_FR-180204_3 / 298_OSI-930_2 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 erk_mapk / rtk / mitosis / pi3k 19_46321845_A_C 170 TMEM70_2 252_WZ3105_3 / 310_YM201636_3 / 303_PIK-93_3 / 301_PHA-793887_3 other / other / pi3k / cell_cyc 1_26457907_T_G / 10_35032524_A_C 171 CSRP3_1 294_MPS-1-IN-1_3 / 328_SNX-2112_3 / 346_THZ-2-102-1_3 / 310_YM201636_3 mitosis / other / cell_cyc / other 2_112722995_T_G 172 MSRB3_1 1372_Trametinib_1 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 22_37816755_A_G 173 PTGER2_1 263_FR-180204_3 / 253_XMD14-99_3 / 306_Fedratinib_2 / 1495_Olaparib_1 erk_mapk / rtk / other / g_integrity 20_49068783_G_C 174 ARHGAP44_2 1248_Daporinad_3 / 344_THZ-2-49_3 / 1495_Olaparib_1 / 1259_Talazoparib_3 metabol / cell_cyc / g_integrity / g_integrity 16_55810697_G_T / 16_55813139_C_T 175 TTC7A_2 326_GSK690693_3 / 310_YM201636_3 / 330_XMD13-2_3 / 254_Quizartinib_2 pi3k / other / other / rtk 11_92353347_C_T / 11_92353483_G_A 176 SLC35F1_1 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 other / erk_mapk / cell_cyc 1_26457907_T_G 177 KRT25_4 330_XMD13-2_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 other / other / mitosis 22_21127217_C_G / 1_26457907_T_G / 22_22643666_C_G / 22_24658344_C_G 178 PAX7_1 263_FR-180204_3 / 310_YM201636_3 / 326_GSK690693_3 erk_mapk / other / pi3k 1_26457907_T_G 179 ENC1_1 263_FR-180204_3 / 310_YM201636_3 / 252_WZ3105_3 erk_mapk / other / other 1_26457907_T_G 180 ERO1L_3 281_Alectinib_2 / 263_FR-180204_3 / 326_GSK690693_3 rtk / erk_mapk / pi3k 1_26457907_T_G / 5_141432375_A_C / 10_6515090_A_C 181 KANSL2_2 281_Alectinib_2 / 226_GSK1070916_2 / 310_YM201636_3 rtk / mitosis / other 1_26457907_T_G / 12_94248247_C_T 182 RPN1_3 344_THZ-2-49_3 / 286_KIN001-236_3 / 310_YM201636_3 cell_cyc / other / other 22_22643666_C_G / 5_141432375_A_C / 1_26457907_T_G 183 PTGER3_2 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 cell_cyc / other / other 1_26457907_T_G / 1_219210601_T_G 184 CACHD1_2 288_WHI-P97_3 / 263_FR-180204_3 / 344_THZ-2-49_3 other / erk_mapk / cell_cyc 1_26457907_T_G / 2_119366546_A_G 185 VPS37D_2 226_GSK1070916_2 / 305_TPCA-1_3 / 303_PIK-93_3 mitosis / other / pi3k 7_72941936_T_C / 1_26457907_T_G 186 ZDHHC17_1 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / mitosis / erk_mapk 1_26457907_T_G 187 TMEM9B_2 228_AKT_inhibitor_VIII_3 / 281_Alectinib_2 / 263_FR-180204_3 pi3k / rtk / erk_mapk 1_26457907_T_G / 11_120298301_A_C 188 HOXD10_1 344_THZ-2-49_3 / 298_OSI-930_2 / 310_YM201636_3 cell_cyc / rtk / other 1_26457907_T_G 189 ITFG2_1 281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 / 326_GSK690693_3 rtk / pi3k / pi3k 1_26457907_T_G 190 EGFL7_1 263_FR-180204_3 / 271_VNLG / 124_3 / 185_Linsitinib_2 erk_mapk / chromatin / igfr 22_22643666_C_G 191 PPP2R2A_5 310_YM201636_3 / 263_FR-180204_3 / 326_GSK690693_3 other / erk_mapk / pi3k 13_20189082_A_C / 12_52771095_C_G / 1_26457907_T_G / 3_126068075_T_G / 22_21127217_C_G 192 BRF2_2 263_FR-180204_3 / 326_GSK690693_3 / 294_MPS-1-IN-1_3 erk_mapk / pi3k / mitosis 22_21283300_G_C / 7_37907554_A_G 193 ATP1B2_1 294_MPS-1-IN-1_3 / 310_YM201636_3 / 290_KIN001-260_3 mitosis / other / other 16_3027533_A_G 194 PTGES3_2 281_Alectinib_2 / 273_CUDC-101_2 / 228_AKT_inhibitor_VIII_3 rtk / chromatin / pi3k 1_26457907_T_G / 1_149813302_A_C 195 NR0B1_2 1259_Talazoparib_3 / 344_THZ-2-49_3 / 310_YM201636_3 g_integrity / cell_cyc / other 1_26457907_T_G / 22_21127217_C_G 196 GALNT10_2 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk 13_99295007_C_T / 13_99314037_A_G 197 TMEM229A_1 263_FR-180204_3 / 1011_Navitoclax_2 / 310_YM201636_3 erk_mapk / apop / other 22_22643666_C_G 198 NCEH1_1 263_FR-180204_3 / 185_Linsitinib_2 / 228_AKT_inhibitor_VIII_3 erk_mapk / igfr / pi3k 6_151015603_C_G 199 C1orf27_1 263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 erk_mapk / cell_cyc / other 15_25177023_G_C 200 TMEM14C_1 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 310_YM201636_3 pi3k / erk_mapk / other 6_31662464_C_T 201 DKK3_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk 11_24729296_G_A 202 LRRC4C_1 263_FR-180204_3 / 344_THZ-2-49_3 / 252_WZ3105_3 erk_mapk / cell_cyc / other 12_52771095_C_G 203 HOXD9_1 263_FR-180204_3 / 344_THZ-2-49_3 / 136_Mitomycin-C_1 erk_mapk / cell_cyc / DNArep 5_140829601_T_G 204 SLC5A6_2 263_FR-180204_3 / 221_TAK-715_2 / 228_AKT_inhibitor_VIII_3 erk_mapk / jnk_p38 / pi3k 1_184808038_A_C / X_46860063_C_T 205 LYPD1_1 274_Belinostat_1 / 273_CUDC-101_2 / 276_CAY10603_3 chromatin / chromatin / chromatin 1_129285_G_A 206 CIB1_1 263_FR-180204_3 / 226_GSK1070916_2 / 305_TPCA-1_3 erk_mapk / mitosis / other 15_25177023_G_C 207 PDSS1_2 263_FR-180204_3 / 1008_Methotrexate_1 / 288_WHI-P97_3 erk_mapk / DNArep / other 15_89633846_A_C / 22_39376109_T_G 208 SHC2_1 326_GSK690693_3 / 263_FR-180204_3 / 310_YM201636_3 pi3k / erk_mapk / other 19_54631904_A_C 209 ATP6V0B_1 1060_PD0325901_2 / 1372_Trametinib_1 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk 1_9850602_T_G 210 SEPSECS_1 341_Selisistat_3 / 286_KIN001-236_3 / 1008_Methotrexate_1 other / other / DNArep 2_28529292_G_T 211 BHLHE22_2 310_YM201636_3 / 263_FR-180204_3 other / erk_mapk 1_26457907_T_G / 22_21127217_C_G 212 FOXC1_1 263_FR-180204_3 / 310_YM201636_3 erk_mapk / other 1_26457907_T_G 213 DMRTA1_1 290_KIN001-260_3 / 286_KIN001-236_3 other / other 7_72949311_A_C 214 CRYBG3_2 263_FR-180204_3 / 294_MPS-1-IN-1_3 erk_mapk / mitosis 22_21127217_C_G / 1_149813302_A_C 215 ANKRD28_1 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 erk_mapk / pi3k 1_26457907_T_G 216 ZNF467_3 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 17_78120770_A_C / 22_21283300_G_C / 5_157491842_C_T 217 MCU_1 281_Alectinib_2 / 344_THZ-2-49_3 rtk / cell_cyc 1_26457907_T_G 218 ALG6_1 281_Alectinib_2 / 294_MPS-1-IN-1_3 rtk / mitosis 1_26457907_T_G 219 DST_1 263_FR-180204_3 / 185_Linsitinib_2 erk_mapk / igfr 22_22643666_C_G 220 CNOT6_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 erk_mapk / mitosis 22_22643666_C_G 221 SLC25A46_1 283_Omipalisib_2 / 228_AKT_inhibitor_VIII_3 pi3k / pi3k 22_22643666_C_G 222 STRBP_3 263_FR-180204_3 / 1259_Talazoparib_3 erk_mapk / g_integrity 22_22643666_C_G / 16_55810697_G_T / 22_21127217_C_G 223 SLFN11_1 263_FR-180204_3 / 344_THZ-2-49_3 erk_mapk / cell_cyc 15_25177023_G_C 224 IL1R1_1 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 11_66624536_A_C 225 PDE9A_2 271_VNLG / 124_3 / 263_FR-180204_3 chromatin / erk_mapk 19_5654163_A_C / 22_19918884_A_C 226 TXNDC11_1 1011_Navitoclax_2 / 344_THZ-2-49_3 apop / cell_cyc 19_624780_A_G 227 NRP1_2 1526_Refametinib_3 / 1014_Refametinib_2 erk_mapk / erk_mapk 3_180647255_T_TA / 15_68718780_C_T 228 QSER1_1 344_THZ-2-49_3 / 310_YM201636_3 cell_cyc / other 6_31464043_C_T 229 TNIP1_1 1526_Refametinib_3 / 154_CHIR-99021_3 erk_mapk / wnt 3_180647255_T_TA 230 LIMS1_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 8_138630731_T_C 231 PNISR_1 265_Tubastatin A_3 / 292_Masitinib_1 chromatin / rtk 15_42142087_A_C 232 MOAP1_1 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 20_53576113_T_G 233 KAT2B_3 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 pi3k / mitosis 19_17618978_T_G / 19_17618863_T_TG / 22_22643666_C_G 234 NBAS_2 292_Masitinib_1 / 286_KIN001-236_3 rtk / other 1_182843301_T_G / 2_112783793_A_C 235 RPAP3_1 281_Alectinib_2 / 310_YM201636_3 rtk / other 16_3027533_A_G 236 PCDH8_1 263_FR-180204_3 / 310_YM201636_3 erk_mapk / other 12_52771095_C_G 237 NRTN_1 185_Linsitinib_2 / 294_MPS-1-IN-1_3 igfr / mitosis 1_149813302_A_C 238 NFE2L3_3 1242_ (5Z) -7-Oxozeaenol_3 / 1014_Refametinib_2 other / erk_mapk 22_32394994_C_G / X_119791251_A_C / 5_113434330_T_G 239 AXL_2 1526_Refametinib_3 / 1372_Trametinib_1 erk_mapk / erk_mapk 4_42616004_T_TA / 4_42616121_A_G 240 FAM84B_1 263_FR-180204_3 / 344_THZ-2-49_3 erk_mapk / cell_cyc 13_24951498_G_C 241 SERPING1_2 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 erk_mapk / pi3k 19_4930892_T_G / 1_151048750_A_C 242 MAN2A2_1 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 18_112338_G_A 243 PPP1R1B_2 1015_CI-1040_2 / 1062_Selumetinib_2 erk_mapk / erk_mapk 6_53899709_T_G / 7_99012221_A_C 244 LIM2_1 211_TL-2-105_3 / 345_KIN001-270_3 erk_mapk / cell_cyc 1_193249713_C_G 245 ENC1_1 1526_Refametinib_3 / 1372_Trametinib_1 erk_mapk / erk_mapk 15_69422319_A_C 246 TXNDC15_1 281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 rtk / pi3k 12_121016539_T_A 247 CTGF_1 1372_Trametinib_1 / 1498_Selumetinib_2 erk_mapk / erk_mapk 10_99533046_A_G 248 EGFLAM_2 281_Alectinib_2 / 252_WZ3105_3 rtk / other 2_217818534_A_G / 2_217817751_A_G 249 ARHGAP10_2 263_FR-180204_3 erk_mapk 22_22643666_C_G / 1_26457907_T_G 250 EBF3_1 344_THZ-2-49_3 cell_cyc 1_26457907_T_G 251 PLAGL2_1 263_FR-180204_3 erk_mapk 1_26457907_T_G 252 XKR4_3 263_FR-180204_3 erk_mapk 1_26457907_T_G / 12_52771095_C_G / 22_21127217_C_G 253 HR_1 288_WHI-P97_3 other 1_26457907_T_G 254 GLB1L2_1 263_FR-180204_3 erk_mapk 22_22643666_C_G 255 GOLIM4_1 263_FR-180204_3 erk_mapk 22_22643666_C_G 256 TMEM127_1 263_FR-180204_3 erk_mapk 22_22643666_C_G 257 USP21_1 263_FR-180204_3 erk_mapk 22_22643666_C_G 258 FAIM_5 344_THZ-2-49_3 cell_cyc 5_141432375_A_C / 1_26457907_T_G / 17_49252681_A_C / 10_122983276_G_A / 15_84654249_A_C 259 COX19_2 326_GSK690693_3 pi3k 22_24658344_C_G / 1_26457907_T_G 260 LRP10_3 344_THZ-2-49_3 cell_cyc 1_26457907_T_G / 12_52771095_C_G / 22_22643666_C_G 261 ASPH_1 1526_Refametinib_3 erk_mapk 3_180647255_T_TA 262 CASP4_1 1526_Refametinib_3 erk_mapk 3_180647255_T_TA 263 PPFIBP1_1 1526_Refametinib_3 erk_mapk 3_180647255_T_TA 264 PRRX2_1 1526_Refametinib_3 erk_mapk 3_180647255_T_TA 265 TADA1_1 1526_Refametinib_3 erk_mapk 3_180647255_T_TA 266 FBXO15_2 288_WHI-P97_3 other 22_22643666_C_G / 22_21127217_C_G 267 RPRD1A_3 263_FR-180204_3 erk_mapk 15_23364657_T_G / 4_190079171_C_T / 15_64381446_G_A 268 HS3ST3B1_2 273_CUDC-101_2 chromatin 15_42142087_A_C / 5_141432375_A_C 269 RBM39_1 286_KIN001-236_3 other 1_26457907_T_G 270 MRPS34_1 1014_Refametinib_2 erk_mapk 3_180647255_T_TA 271 PPARD_1 263_FR-180204_3 erk_mapk 15_25177023_G_C 272 TRIM29_2 1142_HG-5-113-01_2 abl 12_94248247_C_T / 15_50747694_T_C 273 SLITRK3_2 310_YM201636_3 other 12_52771095_C_G / 1_26457907_T_G 274 AOX1_1 185_Linsitinib_2 igfr 6_151015603_C_G 275 WDR41_1 281_Alectinib_2 rtk 2_217818534_A_G 276 WDR60_1 283_Omipalisib_2 pi3k 1_26457907_T_G 277 ELOVL1_1 136_Mitomycin-C_1 DNArep 22_24252424_G_C 278 ISYNA1_1 263_FR-180204_3 erk_mapk 8_22080213_T_C 279 BTBD17_1 281_Alectinib_2 rtk 1_26457907_T_G 280 E2F6_1 281_Alectinib_2 rtk 1_26457907_T_G 281 REEP5_1 281_Alectinib_2 rtk 1_26457907_T_G 282 HIF3A_2 228_AKT_inhibitor_VIII_3 pi3k 1_26457907_T_G / 16_3027533_A_G 283 PLIN3_1 1526_Refametinib_3 erk_mapk 10_92024747_C_T 284 SLC25A43_1 1526_Refametinib_3 erk_mapk 10_92024747_C_T 285 NINL_2 185_Linsitinib_2 igfr 22_22643666_C_G / 1_26457907_T_G 286 ZNF232_2 281_Alectinib_2 rtk 5_141432375_A_C / 6_32040790_G_C 287 SIRT4_5 226_GSK1070916_2 mitosis 19_32862451_C_T / 19_32864163_A_G / 1_26457907_T_G / 15_89806436_T_G / 11_120298301_A_C 288 TP53BP2_1 228_AKT_inhibitor_VIII_3 pi3k 22_21127217_C_G 289 DLGAP1_1 263_FR-180204_3 erk_mapk 22_21127217_C_G 290 ELL2_1 228_AKT_inhibitor_VIII_3 pi3k 22_22643666_C_G 291 L3MBTL1_1 300_CX-5461_3 other 8_22080213_T_C 292 VCL_1 281_Alectinib_2 rtk 5_141432375_A_C 293 FOXN4_1 211_TL-2-105_3 erk_mapk 19_12391643_A_G 294 DGKD_2 288_WHI-P97_3 other 22_24252424_G_C / 11_62825464_G_C 295 UHMK1_2 344_THZ-2-49_3 cell_cyc 6_31710251_C_T / 6_31464043_C_T 296 ATG10_1 1091_BMS-536924_3 igfr 3_120173274_C_G 297 RTN4_1 1526_Refametinib_3 erk_mapk 2_87800520_G_A 298 ZBTB34_2 1091_BMS-536924_3 igfr 11_1244522_A_C / 6_151015603_C_G 299 TRAPPC1_1 1011_Navitoclax_2 apop 16_18896782_A_AAT 300 MAN1A1_1 263_FR-180204_3 erk_mapk 11_61744427_A_C 301 GPR155_1 281_Alectinib_2 rtk 22_22643666_C_G 302 NUP205_1 226_GSK1070916_2 mitosis 17_7604041_A_C 303 DFNA5_1 1526_Refametinib_3 erk_mapk 11_24729296_G_A 304 ESYT2_1 263_FR-180204_3 erk_mapk 2_119366546_A_G 305 ARRDC5_1 1067_CCT007093_3 other 1_112653574_TA_T 306 WWOX_1 185_Linsitinib_2 igfr 22_21127217_C_G 307 TTC12_1 344_THZ-2-49_3 cell_cyc 11_1246619_A_C 308 PHLDA1_1 263_FR-180204_3 erk_mapk 6_151015603_C_G 309 USP44_2 1526_Refametinib_3 erk_mapk 7_155711220_A_C / 15_69422319_A_C 310 PLTP_1 341_Selisistat_3 other 1_176800222_T_C 311 FOXK2_2 1526_Refametinib_3 erk_mapk 17_57105517_C_T / 17_57110197_C_G 312 ERRFI1_1 1372_Trametinib_1 erk_mapk 17_41820457_A_C 313 NCAPG2_2 1378_Bleomycin (50uM) _1 DNArep 17_40554659_A_G / 6_146599135_C_T 314 GNG12_2 1526_Refametinib_3 erk_mapk 4_42616004_T_TA / 4_42616121_A_G 315 GTF2IRD1_2 185_Linsitinib_2 igfr 13_99295924_C_A / 16_4823959_A_C 316 CDH13_1 1526_Refametinib_3 erk_mapk 8_108228165_T_G 317 USPL1_1 1218_JQ1_3 chromatin 11_117206249_T_G 318 C8orf33_2 226_GSK1070916_2 mitosis 1_152805392_A_G / 1_152805488_G_A 319 LARP4_1 344_THZ-2-49_3 cell_cyc 19_21767500_C_T 320 WISP2_3 291_KIN001-266_3 other 15_34382849_C_T / 15_34382220_G_A / 15_34528441_G_A 321 ACTR3B_1 226_GSK1070916_2 mitosis 19_5680513_A_C 322 CACNA1H_1 1091_BMS-536924_3 igfr 1_26457907_T_G 323 KIT_5 1526_Refametinib_3 erk_mapk 19_55181918_C_T / 19_55185911_C_T / 19_55186384_AG_A / 19_55186398_T_A / 19_55186427_G_C 324 PFKFB4_1 1259_Talazoparib_3 g_integrity 2_48582490_G_T 325 PRKCA_1 226_GSK1070916_2 mitosis 14_39074610_T_TAAG 326 PPIB_1 310_YM201636_3 other 12_31206191_C_T 327 GUK1_1 1239_YK-4-279_3 other 3_184849291_A_T 328 TOMM20_1 263_FR-180204_3 erk_mapk 6_33315732_A_C 329 MCFD2_1 1526_Refametinib_3 erk_mapk 7_102356028_T_G 330 ARL2BP_1 1262_UNC1215_3 other 10_17122761_A_AC 331 DSTN_2 51_Dasatinib_1 abl 16_24750598_A_G / 16_24806184_C_T

Results of verification of biomarker responsiveness to sarcoma cancer drugs No. FRH Var_Exp (pval) Var_Drug (pval) Exp_Drug (pval) Ave_VarDrug (pval) Rank One LUC7L_5 1.15E-13 1.91E-09 / 4.67E-09 / 2.52E-08 / 4.96E-08 / 6.43E-08 / 1.09E-07 / 5.42E-07 / 5.69E-07 / 6.37E-07 / 6.61E-07 / 7.24E-07 / 8.41E-07 / 9.74E-07 / 1.12E-06 / 1.30E-06 / 1.85E-06 / 2.11E-06 / 2.61E-06 / 4.14E-06 / 4.58E-06 / 4.71E-06 / 5.01E-06 / 6.19E-06 / 6.58E-06 / 8.57E-06 / 1.05E-05 / 1.13E-05 / 1.15E-05 / 1.30E-05 / 1.46E-05 / 1.53E-05 / 1.53E-05 / 1.59E-05 / 1.84E-05 / 2.07E-05 / 2.21E-05 / 2.43E-05 / 2.46E-05 / 2.89E-05 / 3.30E-05 / 3.88E-05 / 4.17E-05 / 4.23E-05 / 4.72E-05 / 6.02E-05 / 7.09E-05 / 7.70E-05 / 8.39E-05 / 8.89E-05 / 9.55E-05 / 0.000109598 / 0.000148946 / 0.000152384 / 0.000155038 / 0.000170866 / 0.000172159 / 0.000191632 / 0.000193261 / 0.000195059 / 0.000248358 / 0.000327687 / 0.000332153 / 0.000349439 / 0.000359765 / 0.00043352 / 0.000523494 / 0.000575856 / 0.00059693 / 0.000653698 / 0.0067536 0.001650567 / 0.001984983 / 0.002024319 / 0.00212417 / 0.002216293 / 0.002233734 / 0.00226 6673 / 0.002284694 / 0.002445929 / 0.002559027 / 0.002603948 / 0.002721712 / 0.002828387 / 0.003047476 / 0.003355885 / 0.004005854 / 0.004439654 / 0.004491468 / 0.004552462 / 0.005010534 / 0.00514149 / 0.005153885 / 0.005246181 / 0.005770832 / 0.005771327 / 0.006149630 / 0.006149164 9.24E-10 / 7.33E-07 / 1.80E-06 / 5.58E-07 / 5.49E-06 / 8.00E-06 / 1.11E-05 / 3.59E-05 / 2.57E-05 / 1.51E-05 / 0.000278643 / 1.29E-05 / 4.04E-05 / 4.27E-07 / 6.04E-05 / 1.36E-05 / 0.00095004 / 0.000354468 / 7.37E-05 / 0.000178107 / 1.81E-05 / 9.92E-06 / 2.90E -05 / 7.60E-05 / 0.000108534 / 5.28E-06 / 0.000909895 / 0.0001216 / 3.90E-05 / 8.71E-05 / 0.000177412 / 0.000229785 / 0.000206397 / 0.001303165 / 0.000336718 / 0.000220325 / 0.000794135 / 0.005242396 / 0.000138311 / 0.00012461 / 0.002555093 / 3.34E-05 / 0.000212185 / 0.000235135 / 0.003059306 / 0.002031234 / 4.10E-05 / 0.002839464 / 0.001941941 / 0.002111014 / 0.003734935 / 0.00088133 / 0.000260418 / 0.000159567 / 0.000217979 / 0.003045665 / 0.000711377 / 0.004950231 / 0.000568103 / 0.003370008 / 0.003370008 / 0.00032227 / 0.0047926 / 0.000154025 / 0.000752605 / 0.00142213 / 0.001031722 / 0.001286562 / 0.002164935 / 0.0003112 / 0.002677139 / 0.018218112 / 0.002277549 / 0.109175833 / 0.016662 693 / 0.019365546 / 0.002033578 / 0.003027991 / 0.006961933 / 0.025514886 / 0.024966968 / 0.005997059 / 0.001981323 / 0.029427464 / 0.012944297 / 0.01786683 / 0.037151491 / 0.001073091 / 0.000598838 / 0.061847574 / 0.007922021 / 0.022872712 / 0.0598484033 / 0.01228946 0.001105028 / 0.008624497 / 0.010968462 / 0.004721309 1.32E-03 105 2 FZD3_1 0.0000000028 2.0071481202007584e-05 / 1.3062838211579366e-05 / 0.00029640089162746337 / 3.54688199707126e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.408755304649635e-05 / 4.559947241482223e-05 / 0.0003167991900078838 / 0.0097102439 -07 / 5.2109649171464235e-06 / 0.0005120167928359619 / 0.0005120167928359619 / 5.1570472200670454e-05 / 5.2109649171464235e-06 / 0.0006200425273220967 / 1.615375160694009e-05 / 0.002238680629992204 / 0.0004073113752386311 / 0.004583801528895219 / 3.1219185299958266e-05 / 0.0002809149065890676 / 0.00043137964232097263 / 0.0011323441860117745 / 0.0005820808941317769 / 0.0004771627200779347 / 0.001077781567228248 / 0.005510243055764825 / 4.0242980256377906e-05 / 0.0014854545690578267 / 5.831891151164244e-05 / 0.001178242777327155 / 8.058554843717415e-06 / 6.9797948948972793e-06 / 0.03195616924078522 / 3.54688199707126e-05 1968 24071980226081e-07 / 0.003763661611010697 / 0.005510243055764825 / 0.0019333915490623197 4.399804084045925e-11 / 4.8538578704375377e-11 / 5.819712693031694e-10 / 2.963122656898289e-09 / 4.44134906876112e-09 / 1.7977709248154422e-08 / 9.42533011316618e-09 / 1.1148075349332164e-08 / 9.89017118210351e-09 / 2.876945828 8.244633671431711e-10 / 5.45137061905865e-09 / 1.8398488800553676e-08 / 1.804720713536623e-08 / 3.173412287913158e-08 / 9.525086920943969e-09 / 8.7889354451487e-09 / 4.116637231593234e-09 / 2.9588878898633333e-08 / 4.06509489616 2.8027611743995904e-07 / 6.8134604562299e-07 / 2.1399314856199655e-07 / 5.167422923449075e-08 / 5.613208935352902e-08 / 7.672478617521056e-07 / 1.6315736932712637e-07 / 2.4166361947108844e-07 / 1.451917420035471e-08 / 7.300226960 1.5352094129494146e-07 / 1.2282012910353222e-06 / 3.875740564606093e-08 / 1.0494748900823875e-07 / 6.763565198781288e-08 / 5.748334030450384e-07 / 3.353627284114995e-06 / 4.936480143362891e-06 / 2.623117317143412e40589 4.3859213486095075e-0 5 / 5.694315703855324e-08 / 1.2859395153980585e-05 / 5.4888376565657605e-06 / 2.7878746100826557e-05 0.001989712 45 3 LMBR1L_3 0.0000000000 1.3115991775009544e-05 / 4.285325077077582e-05 / 2.6206760013115565e-05 / 8.940710288311502e-06 / 0.00023367518351846944 / 0.00013454362830845267 / 2.7344476741525248e-06 / 0.00015924703665692674 / 5.3436977682081055e-06 / 0.0014252510660 / 0.0003390052340801507 / 0.00018791070326594343 / 5.476715755935002e-05 / 0.0006679513440066498 / 0.00027536436395942185 / 0.0007522453642716858 / 0.0004227612426053383 / 0.0006897961607062659 / 0.004578099476046143 / 9.144525988487157e-05 / 0.0002954537200985898 / 0.0003409317530540561 / 0.00022273590395933135 / 9.752428481242424e-05 / 2.7031767322445152e-06 / 0.0025088064616324564 / 0.0017094647117891196 / 0.0002960302092991554 / 0.001425251066430146 2.4878867617785033e-08 / 5.567969153038763e-09 / 2.2333257462478582e-06 / 1.5621435413932192e-07 / 8.122287757832368e-07 / 1.1594398210650143e-07 / 2.9535242848860537e-07 / 2.5457580110872606e-07 / 1.1054851619419285714-0657 7.434545034394883e-08 / 4.865301638318462e-07 / 7.955105981028123e-06 / 1.7636078112442492e-06 / 3.8772692803359075e-06 / 4.71942956895538e-06 / 7.710653232292368e-07 / 9.824959916701546e-06 / 2.626863984658229e-06 / 5.610135612369372e-06 / 1.985624144436174e-06 / 5.224149339178947e-06 / 1.1780186697477374e-05 / 9.265182617395918e-07 / 7.64885082423866e-07 / 2.3462097383522345e-06 / 7.599816951433106e-06 / 9.768824284806429e-0627 3.191552185410624e-05 / 8.929464106552106e-06 / 2.387431583758606e-06 / 9.679020756011901e-06 0.000605756 34 4 ACTN2_3 0.0000000000 1.6547061876174137e-09 / 7.813308929582946e-09 / 1.3841014381780992e-08 / 7.203525855071736e-08 / 1.8450442549499973e-07 / 3.911794473620475e-08 / 1.4114679221229936e-07 / 0.00012290638155137984 / 3.925563562928499e0669 06 / 1.4592559377242048e-06 / 3.2260283767681983e-07 / 1.193290985948489e-06 / 3.129728827401602e-07 / 5.1156576790479636e-06 / 2.2015209230331294e-05 / 9.735933136603846e-06 / 3.163985594214517e-06 / 3.9350506664998660 07 / 1.545453068208723e-06 / 4.094608902301485e-06 / 6.287076933306607e-05 / 8.143883852558403e-05 / 1.7745606348891978e-05 / 1.9064246508411654e-05 / 3.914526751739124e-06 / 0.0008320152992610897 / 0.00014766547542325887 / 1.07008905253 / 3.456388577880954e-06 8.346739914919394e-10 / 2.6568139110468435e-10 / 1.4297929266679253e-08 / 1.407569556254511e-08 / 7.425827856215124e-09 / 6.044864807461728e-07 / 4.09575569135761e-08 / 2.5796549872310057e-06 / 9.727443509821518e-06 / 1.821337487108634e-07 / 1.1858667937809359e-06 / 3.0908955186716785e-06 / 3.9399829491464125e-06 / 7.557297698538621e-07 / 1.0224109644328716e-05 / 9.68241332215864e-06 / 5.610135612369372e-06 / 7.333671574889317e-06 / 1.60178 1.0121247355306893e-06 / 4.744377470169944e-06 / 4.290604050280735e-06 / 4.1558712164911445e-06 / 4.452894368538964e-06 / 3.298618443622974e-05 / 5.383699135825628e-06 / 5.133532807266582e-06 / 7.79534870420108e-06 / 7.898719458534555e-06 / 4.382658462880079e-06 / 1.2453763214764084e-05 4.29939E-05 33 5 UBXN7_2 0.0000000085 1.2294933823319138e-07 / 0.0009528394445576896 / 2.5977106349140097e-07 / 4.438966867654239e-06 / 4.175847453807821e-05 / 2.2989177020843574e-05 / 1.0258657437467221e-05 / 6.35563211244946e-07 / 9.34271970438383e423_06110 / 6.0398819534333666e-05 / 0.0008312382650131915 / 7.10198962884777e-05 / 0.000737382769650959 / 0.00010754182303257409 / 0.0008657599149476789 / 2.064971477980467e-05 / 0.0021438374376241726 / 0.00011799868875755327 / 6.71344961405297543-05e 7.202281209470204e-05 / 0.0016679197649297247 / 0.0007630126686111583 / 0.00014077366120352972 / 0.0011908689867155006 / 0.00014493182389933843 / 5.074180415291073e-06 1.3148237968215948e-08 / 1.0058181189300685e-08 / 2.866158880903668e-07 / 3.321317019211789e-07 / 2.534746351463287e-07 / 6.649001393280087e-07 / 2.0062892730841753e-06 / 3.0760538337201583e-07 / 1.0537432811773585e4907 2.5056723004222252e-05 / 1.1607897314120808e-06 / 3.6896905862079686e-06 / 2.3529977016400513e-05 / 4.07908271138199e-05 / 2.233895897066247e-05 / 3.9901071706105935e-06 / 9.246191514674586e-06 / 2.970908809716153e-05 / 1.8686 2.7158231870787934e-06 / 2.8767737648395844e-06 / 0.00018285226698360374 / 3.2329494806633123e-06 / 4.56486535636156e-06 / 4.367493381976092e-06 / 2.3915904995124888e-05 / 4.7400303970179404e-05 / 5.693865725616807e9306 / 1.52 05 / 1.901917225424515e-05 / 9.246191514674586e-06 0.000537587 33 6 TRAM2_2 0.0000000000 3.4192931304829014e-06 / 1.3401582342156554e-08 / 4.659755401849588e-08 / 3.633081984870721e-07 / 5.207246052888057e-07 / 1.892412103400743e-05 / 1.3942380334535833e-06 / 2.0535846739106096e-05 / 7.359704703027111e-07 2.2255804 5.5806145526532266e-05 / 4.592877446409494e-06 / 4.592877446409494e-06 / 1.8937125547570738e-05 / 0.00021267966425080588 / 0.00095500393558891 / 1.6992771909182382e-05 / 5.326859676055172e-06 / 0.00020111609082546164 / 5.84826453375e / 4.835640776889601e-06 / 1.017482106342708e-05 / 0.00036820277558262876 / 2.3498756278510995e-06 / 6.031057779485052e-06 / 4.602166722353917e-05 / 4.77141612260032e-05 / 7.647399823593637e-05 / 1.3010063548672435e-05 / 5.70093445 4.322589807838839e-10 / 1.0710488778074884e-09 / 2.2541585510298175e-09 / 1.567254897199143e-09 / 5.8397941769315956e-08 / 1.0411408006909947e-07 / 1.5621435413932192e-07 / 2.6273639848288776e-07 / 7.180942105428594e-08 / 2.84165763 1.75722450249221e-07 / 5.273247808971176e-07 / 2.5292802828220107e-07 / 3.6227709430270065e-07 / 3.9578672189598e-07 / 7.272069346106795e-06 / 3.1693546387669756e-07 / 8.122287757832368e-07 / 6.365489980748545e140 / 07728 5.5398839416627e-07 / 2.1048201026388255e-08 / 4.694603023798112e-06 / 1.2067933247814594e-06 / 1.9510165024642392e-06 / 1.228062366600316e-06 / 3.739290293217579e-07 / 2.595574803350586e-06 / 7.308783057822739e-06 / 3.561518 4.694603023798112e-06 / 1.9523949703929863e-06 6.76165E-05 32 7 CDK13_2 0.0000000046 1.3853996990825065e-07 / 5.7745918340825286e-08 / 1.047470062062923e-07 / 3.956087072154918e-06 / 4.7520049447710837e-07 / 8.531496260442106e-08 / 7.3804316374052654e-06 / 4.47869272440367e-06 / 1.3463919058643852e-06 / 121123 3.6878940499153197e-07 / 0.00016082587811719362 / 0.00011322141355414124 / 0.0008207792485387008 / 0.0012079337533688077 / 2.9520572987073497e-05 / 1.140318186185745e-06 / 7.232001821345798e-06 / 8.539102875978968e-07 / 4.4499857317195 853e08 -06 / 0.00015124776392064736 / 8.137865842046858e-07 / 8.776477751355082e-06 / 7.3804316374052654e-06 / 2.5501614319254746e-05 / 6.930572497830363e-05 / 9.349083309404483e-05 / 3.4999466370498394e-05 / 8.383566724982507e-05 8.041496040856773e-10 / 1.1212152252396135e-09 / 2.2149509398591615e-09 / 6.49921859944133e-08 / 1.146609360749861e-08 / 9.315547292848514e-09 / 7.076208121664563e-08 / 1.5105555334027616e-07 / 1.4275728512486712e-07 / 3.39980967 1.7384894474420941e-07 / 1.7501056125582978e-07 / 1.6481167858879217e-07 / 7.741434363358432e-07 / 1.5033075637026901e-06 / 2.258352385302198e-06 / 1.0175118608827892e-07 / 1.054741547163592e-06 / 7.6950131270099130707 1.1584887732120262e-06 / 1.8682249268554782e-07 / 4.110133905921353e-07 / 2.4667255985252546e-05 / 5.724946196061661e-07 / 4.748434316553696e-06 / 6.535278991184282e-07 / 1.477642900652424e-06 / 3.526294982097946e-76 / 76763 2.387431583758606e-06 / 2.412245892896333e-05 8.92798E-05 32 8 BCL11B_3 0.0000000011 2.1691780926743226e-07 / 8.225833660011401e-07 / 1.789237622088428e-06 / 2.0356690840892754e-08 / 3.987613565444208e-05 / 9.360516011381817e-06 / 8.9395947547362e-05 / 3.466378757720392e-06 / 1.2385647799184097e-05590 0.00028446811679125046 / 4.3322170131610347e-07 / 3.6694829495818446e-05 / 1.3319185354685384e-05 / 0.0001450120364959482 / 0.0012382643384124116 / 0.00011198347385438923 / 1.2225430006781737e-05 / 2.2121210908325923e-06 / 0.0041340374259435115 / 0.00038512818063312726 / 0.00330460988510783 / 0.0011551309927923857 / 0.004248586177433409 / 8.696575941061198e-06 / 0.00035640811201797775 1.4826443090493311e-08 / 2.2740294469952764e-08 / 6.336269186082428e-09 / 3.539172375371934e-08 / 4.7609504610906553e-08 / 1.7960393747350935e-07 / 4.4916588042332195e-07 / 4.870463435270994e-07 / 2.0751734487343673e08 2.613509065423129e-07 / 4.2998193211784016e-08 / 2.9189015908569146e-07 / 7.796320698489975e-07 / 3.287953600510885e-07 / 4.184506818533476e-07 / 3.425164804138365e-07 / 2.6927928108537883e-07 / 1.5690808649462252e7461 1.3924361879300207e-06 / 1.895443350505234e-06 / 2.370093060682893e-06 / 3.622834973607711e-06 / 3.7283263548613296e-06 / 6.922058937247929e-06 / 2.3405099437428686e-05 / 0.00010413370355979186 / 1.2402625610892681e-05 535e 06 0.00058073 31 9 LONRF1_4 0.0000000000 2.3042263304124516e-06 / 8.182623816859019e-08 / 7.449035561194172e-08 / 3.271165707863933e-07 / 3.872601102158526e-06 / 8.238465335223179e-05 / 1.020006295103392e-05 / 4.780055898330748e-05 / 6.0132262668712315e-0594 0.0062583380 05 / 9.377014819070716e-08 / 1.8750944559946824e-05 / 0.0002257748867625031 / 4.61034011703085e-05 / 6.434547053133198e-06 / 0.0024160298697904117 / 6.16484303738615e-05 / 6.232941894500062e-06 / 8.832466534601092e-05 / 0.0073457393 -05 / 5.3959564521511103e-05 / 8.545068477488772e-05 / 0.0010681118057163815 / 0.0006404527227598945 / 0.0010528904729959797 / 4.7004221317801894e-05 2.871690193004347e-09 / 7.780203727430123e-11 / 1.1090993827240565e-09 / 4.885836011088783e-09 / 4.3845626278981783e-08 / 3.800967952270995e-08 / 6.548683737212715e-07 / 9.934081050522841e-07 / 1.225883649817038607 9.84639797132252e-07 / 1.0962753584080669e-07 / 2.504876298772149e-06 / 4.981808633338559e-06 / 9.170385978844389e-07 / 3.2430481749669908e-06 / 5.197036451631831e-06 / 2.542113471225459e-06 / 2.116056737675851e 3.74526002970195e-05 / 3.3592564682108814e-06 / 6.814920333363255e-06 / 3.2430481749669908e-06 / 6.4967649552906986e-06 / 4.180561542903392e-05 / 3.3264582250052445e-05 / 8.095222217568488e-06 / 6.77844689688323e-05 0.000225153 29 10 NUDT16_1 0.0000003288 2.7109747094287326e-07 / 5.2109649171464235e-06 / 9.224071980226081e-07 / 0.0004422271229621968 / 1.3062838211579366e-05 / 0.004583801528895219 / 0.0004771627200779347 / 3.2501044823812903e-07 / 5.2109649171464235e-06 / 0.00148545979797979797 05 / 0.001077781567228248 / 3.54688199707126e-05 / 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1.1263759452799203e-06 / 0.005398390884784092 / 0.00014547367344876742 / 0.0008581803853921776 / 9.971939174478468e-05 / 0.0001395680222164631 / 0.0005345324666238675 / 0.0026702661426604127 / 0.0036790499750236597 / 0.00036105139567184824 / 0.004298857351174951 / 0.0003301911422383287 / 0.006072266622156599 / 0.0028963504457353837 / 0.0008619933402586612 / 0.0014783442733670397 / 0.002082636216901017 / 0.0038265104822853674 / 0.0012393227037226365 / 0.0001249119186090808 / 0.0014783442733670397 / 0.009354429645569597 / 6.267778266652492e-05 / 0.0010353911778693099 / 0.0067509647795811235 / 0.00017366806695686554 7.120406194930282e-10 / 1.3196888168609393e-07 / 9.697204620602088e-09 / 1.088769714704053e-07 / 7.422682196769718e-08 / 6.17052942560377e-06 / 1.3710585742644193e-06 / 3.457696931263268e-08 / 2.6405169262238316e-06 / 1.0362770769 1.460759694934436e-06 / 3.8350091086392213e-07 / 1.266977339256832e-07 / 5.261863247063795e-07 / 1.698316254132078e-07 / 2.8478812173765797e-06 / 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1.5568 1.3255462641590073e-07 / 1.2540923765124735e-08 / 1.1641859357749167e-06 / 6.487275081622067e-07 / 6.067873978076284e-07 / 4.061559955180453e-06 / 3.085926641657104e-07 / 2.1304437118144328e-07 / 1.614987656365666e-06 / 1.6505215 1.100046276296759e-07 / 7.257376518723062e-08 / 6.752087125171909e-06 / 5.013481886934968e-07 / 7.94905114529822e-06 / 2.0096587893651723e-06 / 1.4098818268841097e-06 0.00054563 27 13 FUCA2_5 0.0000000000 7.326897656479634e-08 / 6.283050277058581e-07 / 6.33011695404466e-08 / 1.557810894407547e-08 / 1.4405701094138483e-07 / 8.973492705988831e-07 / 1.2247130912164364e-05 / 1.615099681752137e-08 / 1.0657346371809004e-06 1.9131942692024663e-06 / 1.7122549667747245e-06 / 1.8435980433182962e-05 / 1.6062625517222244e-05 / 2.1026075258297646e-05 / 4.784284498191245e-06 / 5.047975911248677e-07 / 3.7790277202725207e-05 / 0.000270963272846968809 06 / 1.2637608316913067e-05 / 3.318559639876234e-05 / 0.00019702583169390873 / 0.0001046372470755123 / 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2.0842424513236034e-05 / 0.0001466471398885516 / 1.960392177885001e-05 / 0.00014017916355145386 / 3.5078700784406 / 2.4179541415210912e-05 / 4.771691927687007e-05 / 0.0018357138624291076 / 0.0004214818735639107 6.669284403690585e-09 / 1.0986500719843909e-07 / 1.2920530726355395e-08 / 7.144193992690255e-07 / 8.897098518847435e-08 / 2.143448052078468e-07 / 1.1024290553572537e-07 / 1.4570264791055579e-06 / 5.394353982216976790787 4.261784119390405e-06 / 3.913300846178839e-06 / 3.851296907021924e-07 / 1.3419887854662606e-06 / 7.36330097877341e-07 / 6.509968171609093e-06 / 6.683327596452262e-07 / 2.3915368068802614e-06 / 6.713901833795875e-06e 1.4047060577114316e-06 / 1.484859827728269e-06 / 2.9956513765454837e-05 / 1.3836812552345798e-05 / 1.8400365047125074e-06 / 2.8632422146042694e-05 0.000119677 26 15 JAKMIP2_1 0.0000003136 1.887107728600381e-05 / 0.00011602560329098725 / 0.0001432193232982916 / 0.0001432193232982916 / 0.0002441254991542676 / 0.006227948945630897 / 0.0003000003635118199 / 0.003136344446815041 / 0.0010434554869778357 / 0.001424661642376461 / 0.0004963923899259765 / 0.00011484315511043709 / 0.0011412468921657625 / 0.00033206653362091303 / 0.0011737393453168934 / 0.00021988598115354305 / 0.00019784908671616698 / 0.00033206653362091303 / 0.0007934067413946306 / 0.0007228851823325908 / 0.0003242200414121999 / 0.0033705319486407362 / 0.0020865035640383737 / 0.004284102869708787 / 0.001710012299865077 1.5055398107137094e-08 / 1.1317898810241505e-07 / 3.014192988473054e-07 / 6.562524735452552e-07 / 1.2620827414204395e-06 / 1.3813768678383736e-05 / 3.0528002185491916e-06 / 4.084105074757677e-06 / 1.276826259182333463506 5.301506195235781e-06 / 3.73908096007415e-06 / 2.881552294460198e-07 / 3.7090918031637474e-06 / 8.877144806640423e-06 / 1.0731167574000379e-05 / 4.60217321009711e-06 / 3.1972497431176806e-06 / 7.72630923511333e-06 / 7.78830923511333e-06 / 9.788 1.694391766170071e-05 / 1.9122978701285485e-05 / 2.1160442665025628e-05 / 0.00012419843212817223 / 3.665339330112523e-05 0.001203905 25 16 RHBDD2_2 0.0000000381 1.3853996990825065e-07 / 4.7520049447710837e-07 / 3.956087072154918e-06 / 1.280613569121123e-06 / 8.539102875978968e-07 / 2.5501614319254746e-05 / 0.0005420861101080113 / 5.7745918340825286e-08 / 8.776477751355082e-06 / 0.0073697720 e-06 / 1.140318186185745e-06 / 7.232001821345798e-06 / 3.9201554157572025e-06 / 4.4499857317195853e-07 / 6.930572497830363e-05 / 1.047470062062923e-07 / 0.00019163973853294472 / 7.3804316374052654e-06 / 3.6878940499153197e08 / 0.0012079337533688077 1.3993846023737915e-07 / 4.7782451098120726e-08 / 1.34825995314718e-07 / 9.277238538824435e-08 / 7.956677787090288e-08 / 1.9225900129783712e-07 / 4.7263934234281247e-07 / 4.706709396786997e-07 / 6.949261184656789e-07 / 7.829247 5.071860028688062e-06 / 6.993311385406026e-06 / 1.4497257721405869e-06 / 1.0714836567004093e-06 / 1.4372683450836863e-06 / 4.455852411812759e-07 / 1.815987875798767e-05 / 5.0475687702261924e-05 / 2.8193572587039603e77 9.053292911304865e-07 / 7.583935924635759e-06 / 9.83485693819911e-06 9.91481E-05 23 17 NELL2_2 0.0000000034 1.6974372024295342e-05 / 6.21390552863653e-07 / 7.492219023207615e-07 / 0.00033397296479027066 / 6.419532166056714e-06 / 3.680752556412065e-06 / 2.702881264505673e-05 / 0.0001892136695208884 / 0.00013627250802194024 / 4.7592039918405816 6.893999398193879e-07 / 2.7044709406151057e-06 / 1.030767276264569e-05 / 0.00011664561575068539 / 7.396819433180742e-05 / 0.0033003547134611197 / 0.0007339964856567068 / 3.212738000062656e-05 / 5.509863153367014e-05 / 0.00141345655091 1.805210992172401e-08 / 1.036277076972443e-06 / 1.6727928235519174e-05 / 1.3595686728091487e-05 / 3.109078579168171e-07 / 2.9751938937015323e-06 / 3.0194508969201275e-06 / 1.6481167858879217e-07 / 1.0183622735900536e-06 / 2.5513434 8.778520319265194e-07 / 4.509011181702684e-05 / 3.1588674679295282e-06 / 4.870956378452621e-06 / 4.222740574602922e-06 / 9.393121861778026e-06 / 5.533180942415662e-06 / 2.6252332329450155e-05 / 8.461228664041275e-0611297130 5.2787519047573424e-05 / 2.9042216064749748e-05 / 4.1781335008242154e-05 0.000322735 23 18 LIPI_3_23 0.0000000000 8.447946079053626e-08 / 1.205208755759072e-06 / 4.854502381230392e-07 / 2.1301603555625764e-05 / 6.853246565784258e-06 / 2.1960012732279454e-05 / 2.6827365804354637e-05 / 1.2548296867935075e-05 / 0.0002009891841455023 / 4.514325 05 / 3.312532784218011e-05 / 6.011489855493573e-07 / 0.00014831370330060418 / 1.7445373847640036e-05 / 0.004714448601828642 / 0.0032002760896811776 / 0.0004620869369249564 / 0.0003755600058949459 / 1.2884839156193493e-05 / 0.001151273616214569613 5.468987072460599e-10 / 2.6158726903289238e-08 / 3.565426338432271e-08 / 8.478661382630348e-07 / 3.875609327625631e-07 / 4.840300983601908e-07 / 8.703948887755087e-07 / 9.72132002734069e-07 / 6.098991982334273e77607 1.739637519533283e-05 / 3.2315430831611734e-06 / 8.154288030550316e-08 / 3.3855189139433126e-06 / 1.76044274336364e-06 / 3.077281478322042e-06 / 7.717215517819916e-05 / 3.986852616595454e-05 / 0.0001488041159355547 / 4.81219243547 05 / 2.5976982501110966e-05 / 1.2619626971823594e-05 0.000505799 23 19 RUNX1_1 0.0000001763 3.2501044823812903e-07 / 9.2240719 80226081e-07 / 2.0071481202007584e-05 / 9.289397717877934e-06 / 5.1570472200670454e-05 / 0.005510243055764825 / 0.00193339154906231231 / 2.408755304649635e-05 / 0.0005120167928359619 / 2.710974709423062807 / 0.0006200425273220967 / 0.00029640089162746337 / 5.2109649171464235e-06 / 8.058554843717415e-06 / 5.2109649171464235e-06 / 0.0006813940301036226 / 0.0003167991900078877 / 5.831891151164244e-05 / 0.0017723102864169204 / 6.979794879972793e 1.1641966632063906e-10 / 7.92535031547177e-09 / 5.753632350484074e-09 / 1.0677978948737271e-07 / 3.665113066608255e-07 / 1.4992785773118291e-06 / 1.2569627975426034e-06 / 4.294667785263063e-07 / 2.58629690488761e007 2.7175791335738627e-06 / 5.643067361003201e-07 / 1.7425168489071174e-06 / 1.244203208123666e-06 / 1.3319999198783528e-06 / 7.864816120590302e-08 / 1.998199593822845e-07 / 3.4658375428977435e-06 / 1.228062366600316e-06 / 1.35964405 1.714256584966273e-06 / 4.1558712164911445e-06 / 1.5033075637026901e-06 0.00051678 23 20 UGT3A2_1 0.0000012269 9.224071980226081e-07 / 3.2501044823812903e-07 / 2.408755304649635e-05 / 6.979794879972793e-06 / 0.0003167991900078877 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 2.0071481202007584e-05 / 8.058554843717415e-06 / 0.00040731137 e-06 / 0.0005120167928359619 / 3.54688199707126e-05 / 0.0019333915490623197 / 9.224071980226081e-07 / 0.017443989828652796 / 1.615375160694009e-05 / 5.2109649171464235e-06 / 5.1601659937199475e-05 / 0.00029640089162746337 / 0.00193339154154 1.381799790744931e-09 / 1.805210992172401e-08 / 9.694448730531385e-08 / 4.403550218821958e-07 / 2.9355105945215545e-08 / 1.045969028083387e-07 / 3.835974713623205e-06 / 2.3222021704967167e-07 / 4.773025688625418e-08 / 9.343660 3.6689667424468134e-07 / 2.4140542299703294e-06 / 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0.0062926107897605076 / 0.008954836987534829 / 0.0013997024178051241 / 0.0017438515808585928 / 0.005852051539088946 / 0.0013991989944309945 / 0.0037308274054686026 / 0.001807326102912818 / 0.0014458717426393303 / 0.0006825622924508404 / 0.006160732768120326 / 0.008954836987534829 / 0.004687460046810221 / 0.0001360945704417454 / 0.0072609125485500695 2.612437800154611e-10 / 1.5925972264030232e-08 / 3.100531350503503e-08 / 6.448536988230897e-08 / 5.466544241455998e-07 / 3.2169896739895314e-07 / 3.1906789245845806e-06 / 2.3096174786096604e-06 / 1.0141504136839242e-06 / 2.260690937267 9.279972919171246e-07 / 2.847754855927293e-07 / 6.680245031011018e-06 / 5.490090984753377e-06 / 1.077519353313373e-06 / 5.376695975590836e-06 / 4.7530598444137695e-06 / 2.3590259977159812e-06 / 8.340398610953811e06 0.003387824 19 27 RBM11_5 0.0000000000 1.4526084780295787e-06 / 5.443773486089936e-07 / 1.1971991474232777e-05 / 6.91934628205793e-05 / 2.5796294158785155e-05 / 2.552372456547772e-05 / 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4.51316772311888e-06 / 2.621113516811208e-07 / 1.9091723806799227e-06 0.000798393 17 30 ENPP3_2 0.0000000002 7.220251902586713e-08 / 1.5415033312027603e-05 / 2.140496501618477e-08 / 1.0829140297466289e-09 / 4.864296167501907e-07 / 4.1398213999064624e-06 / 1.3483681400210042e-06 / 6.882770012055959e-06 / 5.9617084438303865 1.2072926853768964e-05 / 1.1605014260398891e-06 / 3.934765724180659e-07 / 1.3398427589553948e-05 / 2.132615896596937e-05 / 2.4103457859893014e-05 1.9517835933891448e-08 / 2.248231048691535e-08 / 4.830482337300574e-08 / 1.481967113051988e-07 / 4.175954165049041e-08 / 1.6171122367004618e-07 / 1.6052769492778243e-06 / 4.900800780379338e-07 / 9.924621104960267e-566 / 5.843072350429807e-07 / 3.2579388947351196e-06 / 1.1836495389262217e-06 / 1.1411599622062492e-05 / 2.843023304997815e-06 / 1.828727174279431e-05 8.88611E-06 16 31 RBM33_1 0.0000000000 9.289397717877934e-06 / 3.2501044823812903e-07 / 6.979794879972793e-06 / 5.1570472200670454e-05 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 4.491442887170463e-06 / 2.408755304649635e-05 / 5.2109649171464235e-06 / 3.546 3.54688199707126e-05 / 0.0004073113752386311 / 5.1601659937199475e-05 / 0.00043137964232097263 / 4.0242980256377906e-05 / 5.2109649171464235e-06 8.944918223939934e-09 / 9.053698775288811e-09 / 2.5457122572689533e-07 / 1.5628889781375459e-07 / 9.626516148430137e-08 / 4.9661337040464625e-08 / 1.4653913639914694e-07 / 9.345028580131548e-07 / 1.2202889190119188e-07 / 206 3.4985449908631084e-07 / 3.210007225110076e-06 / 3.041361665158829e-06 / 7.856862302531046e-06 / 1.7638568513415927e-06 / 8.270219208624064e-07 6.93645E-05 16 32 MYOM2_1 0.0000000034 3.2501044823812903e-07 / 9.224071980226081e-07 / 1.3062838211579366e-05 / 9.289397717877934e-06 / 9.224071980226081e-07 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 6.979794879972793e-06 / 0.001077781567228248 / 05 / 0.0006200425273220967 / 5.1570472200670454e-05 / 3.1219185299958266e-05 / 0.0005820808941317769 / 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2.32003591797698e-0673 1.3425131 2.4253616535611087e-06 / 9.891342242857947e-06 / 1.1746244916516119e-05 / 2.092495310550426e-06 / 3.681660463815629e-06 / 1.4268112459432864e-05 0.000239944 16 34 FAM19A5_1 0.0000000251 2.051237402337122e-05 / 0.0001249119186090808 / 1.1263759452799203e-06 / 0.00014547367344876742 / 0.004362771524153584 / 6.267778266652492e-05 / 0.00036105139567184824 / 0.004298857351174951 / 0.0026702661426604127 / 0.000294428861370939 3.7316428195760516e-08 / 4.801672877175668e-08 / 2.2512706653969313e-08 / 2.2270178280725655e-08 / 1.1663586146149853e-07 / 5.1617837573062526e-08 / 9.920288294972892e-08 / 1.0628762332633252e-07 / 7.803934546881044e0707 3.618961161943627e-07 / 1.737206632640488e-06 / 1.114198886925796e-06 / 1.737206632640488e-06 / 4.390716794223026e-06 / 1.5851926645157727e-06 0.001409487 16 35 CDK6_2 0.0000001305 0.00013786395373714154 / 0.00012482662815781762 / 6.30950668542991e-06 / 3.539797690840022e-05 / 0.0021106959648809795 / 0.0019402604943496325 / 0.0004050172910570013 / 0.003362553960006399 / 0.0013208680612235583 / 0.00017037141729627674 / 0.00702600 780 625 1.9544766970910803e-08 / 3.902848227411897e-06 / 1.1734588197031495e-06 / 1.1118487852102413e-06 / 1.8215667472555084e-06 / 1.2168005067226621e-05 / 1.2378495979370532e-05 / 1.2610279737677179e-06 / 7.5858403127194657 1.4962029489277431e-05 / 1.155615785434093e-05 / 9.614370500489897e-06 / 5.003114862001264e-06 / 5.28580544479192e-05 / 1.4068709149077956e-05 0.002220337 16 36 C1orf54_1 0.0000004284 0.0014458717426393303 / 0.0020037138718268558 / 4.335544688590604e-05 / 0.0016610593752756947 / 6.184726372815994e-05 / 0.0001877376372184388 / 0.004687460046810221 / 2.6541144234526445e-05 / 0.0072609125485500695 / 0.00020855415394078816 / 2.305129761580506 4.431617867534599e-08 / 9.764176338067594e-08 / 1.6551951268345963e-08 / 5.4670195572463556e-08 / 8.693119479065898e-08 / 6.467247715906918e-08 / 1.3820781181904612e-07 / 2.601353524092188e-07 / 1.4346332512235168e724 2.1381221213988253e-05 / 2.0697206630187898e-07 / 2.0216248384142136e-05 / 1.3296295127951121e-05 / 4.089595896778703e-05 / 6.182750614867968e-06 0.003194747 16 37 HOOK1_1 0.0000000509 3.2501044823812903e-07 / 2.7109747094287326e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 9.289397717877934e-06 / 0.017443989828652796 / 0.0019333915490623197 / 5.2109649171464235e-06 / 0.0003167991900078877 / 8.006126 / 0.0004073113752386311 / 0.001077781567228248 / 2.408755304649635e-05 / 0.03666459832926511 6.576012762267339e-08 / 1.4455622042691941e-06 / 4.885610187770645e-07 / 3.76701623356669e-07 / 1.8059093721170035e-06 / 2.676171176620618e-05 / 5.749753783810232e-05 / 1.1638593888237151e-05 / 8.6335388114483390606 2.090650282526137e-06 / 2.5661246047916315e-05 / 1.5202656143498954e-05 / 9.9612781999649e-06 / 1.6231643656615e-05 / 0.00012445882667471073 0.003621722 16 38 EVI2A_1 0.0000000779 2.0071481202007584e-05 / 1.3062838211579366e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 3.2501044823812903e-07 / 0.0006200425273220967 / 3.54688199707126e-05 / 0.006968336904458093 / 5.2109649171464235e-06 / 99064 0.0006813940301036226 / 2.408755304649635e-05 1.5609086500143182e-09 / 2.4274791706684804e-07 / 1.3635987406508816e-07 / 1.6189487637413584e-07 / 3.704245549261797e-08 / 5.850917111819974e-07 / 4.021754229335225e-06 / 5.99711639772174e-06 / 5.939256052201768e-07 / 927 1.752058259452043e-06 / 3.3967361752805547e-06 / 1.4521128153120201e-05 / 2.839421384468485e-05 / 1.9278657989741134e-05 0.000856793 15 39 KDSR_1 0.0000003143 1.887107728600381e-05 / 0.0005437871552770366 / 0.002087197919276702 / 0.0001432193232982916 / 0.00021988598115354305 / 0.002087197919276702 / 0.0010434554869778357 / 0.0002441254991542676 / 8.177669445709026e-05 / 0.006227948945630897 / 0.00161934022383 88893 7.774619885339959e-09 / 9.17707137009986e-09 / 6.345932895218097e-07 / 3.824093835557216e-08 / 4.870463435270994e-07 / 1.781378071484659e-07 / 1.5486153095797136e-06 / 3.2667817640867473e-06 / 9.66394881627529e817 7.511357995471599e-06 / 2.1985427007215493e-06 / 4.469268122727537e-06 / 5.302698252478667e-06 / 5.826180628047725e-05 0.00108321 15 40 TRIM69_1 0.0000000466 1.887107728600381e-05 / 0.0002441254991542676 / 0.0001432193232982916 / 0.0004863107130580812 / 0.0001432193232982916 / 0.00021988598115354305 / 0.00021988598115354305 / 0.0005437871552770366 / 8.177669445709026e-05 / 0.0016193402238388898 / 0.006227948945630897 1.1433357759584753e-08 / 8.836349820396399e-08 / 1.0186144265985267e-07 / 9.978329579501906e-08 / 5.327953099928334e-07 / 2.0403148485445152e-07 / 1.36202730898669e-07 / 1.8476610323825603e-07 / 1.9599293797405736e62606 4.736723443537097e-06 / 3.824375400480388e-06 / 1.7111709589036534e-06 / 5.410761494405694e-07 / 1.1672532290928993e-05 0.001913028 15 41 FAM69A_1 0.0000000702 0.0013130417279779386 / 0.00015668136762185704 / 0.000580627296776329 / 0.00021513618339111576 / 0.0006379488254521119 / 0.0038002956245117296 / 0.00023863087793556863 / 0.009089976463332457 / 0.009732706737130784 / 0.0015596001225492795 / 0.0012028677089548085426 0.0079887 5.207979195444387e-10 / 2.3954906890799492e-08 / 8.376642315944637e-08 / 3.029086308872845e-09 / 8.2602839443737e-08 / 4.5432680388905903e-07 / 3.4215164228215663e-07 / 3.6227709430270065e-07 / 1.1119851588379871e-06456 9.884962 6.58864064133256e-07 / 1.9066424564105585e-07 / 1.0175118608827892e-07 / 9.736821003526402e-06 / 2.2836387735375516e-06 0.003082358 15 42 MCF2_1 0.0000000950 0.002107325343692074 / 0.0007073001228128905 / 0.0016226906289916678 / 0.013331886853589549 / 0.004410274724633273 / 0.004410274724633273 / 3.1219185299958266e-05 / 0.0011323441860117745 / 0.005133998810813905 / 8.807499017205126e-05 / 0.008672939675174894 2.8385942053147423e-07 / 7.000874559889031e-07 / 1.0191814816838582e-06 / 1.937510906526569e-06 / 1.219795851846249e-06 / 1.1273301221243648e-06 / 7.451700758866295e-08 / 4.510350188873355e-07 / 1.6503324272286632e419 7.86885268932808e-06 / 2.4523766799232255e-06 / 8.771491504288576e-06 / 4.472728712108301e-06 / 6.181222965809451e-06 0.004209327 15 43 DNMT3A_1 0.0000000038 3.2501044823812903e-07 / 2.7109747094287326e-07 / 9.224071980226081e-07 / 1.615375160694009e-05 / 9.289397717877934e-06 / 0.017443989828652796 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 5.1570472200670454e-05 / e-05 / 0.0003167991900078877 / 0.04025623380130843 / 0.016412811603890378 8.647692450087712e-10 / 3.609830399524262e-08 / 1.0850349172583042e-07 / 4.2367786991922625e-07 / 5.547034323026097e-08 / 4.995600154079587e-06 / 9.034850264291034e-07 / 1.1942660873924224e-07 / 3.47640466680970139406 4.064896475030508e-06 / 5.950697198132815e-06 / 2.1639192493163854e-06 / 0.0003267886041800874 / 2.5073506475872135e-05 0.005016004 15 44 RAP1GAP_1 0.0000001086 1.3062838211579366e-05 / 9.224071980226081e-07 / 3.2501044823812903e-07 / 3.54688199707126e-05 / 5.2109649171464235e-06 / 2.7109747094287326e-07 / 9.289397717877934e-06 / 8.058554843717415e-06 / 5.2109649171464235e635 6.979794879972793e-06 / 5.1570472200670454e-05 / 9.224071980226081e-07 / 0.0004073113752386311 1.0234263973416661e-07 / 8.919463455114289e-08 / 3.3072632243081114e-08 / 1.5105555334027616e-07 / 2.5836122972488502e-08 / 1.2756238211643116e-07 / 9.299416219218907e-08 / 2.1342000804921115e-07 / 7.37724046840261e70007 3.3529930477004465e-06 / 2.385355833544641e-06 / 9.364193044327943e-08 / 5.244484117278139e-06 4.06208E-05 14 45 GCNT1_2 0.0000000002 2.78484877909426e-05 / 4.864296167501907e-07 / 9.764023441666015e-05 / 2.140496501618477e-08 / 0.00016651089487352638 / 3.0074215404236193e-05 / 0.0006617980305097352 / 1.3483681400210042e-06 / 4.031241782169131e-05 / 1.1981309904 e-09 / 7.220251902586713e-08 / 3.539399887995572e-05 1.8148339446273985e-07 / 6.847165231186148e-07 / 2.165545875875814e-05 / 2.3188274882197003e-07 / 6.0280690987430294e-06 / 5.2750455191025595e-06 / 4.06671138458547e-05 / 1.2997762974345022e-06 / 2.217018783282958306-368 / 9.170085944984048e-06 / 1.1905756638522483e-06 / 5.8239343353291375e-06 / 2.5038906043292028e-05 7.59475E-05 14 46 ACVR2B_1 0.0000024645 0.004342013504637762 / 0.010062997503423064 / 0.01546878234616017 / 0.0043172887751955534 / 0.004147048109487421 / 0.0027366161949255864 / 0.004302356273800125 / 0.003851105873342487 / 0.010924554738209911 / 0.0034419337702655166 / 0.0016993523409038112 / 0.00881541006358 4.6969645977238944e-08 / 1.0646048244254027e-06 / 2.074984122638114e-06 / 1.6464210539762824e-06 / 3.55074742901801e-07 / 8.336014361253352e-07 / 1.0819897944403119e-06 / 6.649001393280087e-07 / 1.771560615564129e-07 / 2.1882250 5.884742871708681e-07 / 1.359935106570381e-05 / 2.757047405189331e-06 / 3.7316428195760516e-08 0.006036009 14 47 FLII_1 0.0000003706 0.013438701196916187 / 0.0013131196768949175 / 0.001313597832987636 / 0.010966427251690712 / 0.0010967995115722952 / 0.00283637665495315 / 0.020637719307260594 / 0.009544509177234737 / 0.011113919331766907 / 0.002612407689400646 / 0.00014659710165947198 / 0.0117431113167 2.0358630016163756e-07 / 9.38178289658818e-07 / 1.5768550290633048e-06 / 4.170842922005371e-07 / 1.2667845868111258e-06 / 5.267900245960507e-07 / 1.0328138955557601e-05 / 2.5703309767846595e-06 / 9.713959639172909e-0677 5.689594876108628e-07 / 5.210656857814663e-06 / 2.5072452506982253e-06 / 2.1338889654131307e-06 0.00796357 14 48 TGS1_1 0.0000000593 0.005817871625455744 / 0.001612584660708291 / 0.0053998526759721725 / 0.01862777129511709 / 0.0053998526759721725 / 0.01862777129511709 / 0.007245502894805505 / 0.0077845190703610834 / 0.006739142831934305 / 0.02903454585336941 / 0.04017463251009088 / 0.012410515410339 1.1383417891948003e-06 / 3.9578672189598e-07 / 9.316488159288118e-07 / 1.3710585742644193e-06 / 2.6082574074268862e-06 / 1.3166677315221278e-06 / 1.7045413888506067e-06 / 3.708237186148934e-05 / 5.818012600528764e06 2.2843722976730473e-05 / 8.803523078622629e-06 / 3.9399829491464125e-06 / 3.3285882689135296e-05 0.014553902 14 49 XG_2 0.0000000005 1.3401582342156554e-08 / 1.7203065067402312e-07 / 1.3942380334535833e-06 / 4.659755401849588e-08 / 5.207246052888057e-07 / 1.892412103400743e-05 / 1.017482106342708e-05 / 4.835640776889601e-06 / 2.349875627851099506-7353 7.359704703027111e-07 / 3.633081984870721e-07 / 2.0535846739106096e-05 1.9199076986833634e-08 / 5.521935167514162e-09 / 3.002088015685159e-08 / 1.1673991664313873e-07 / 2.339150064869274e-07 / 7.850967660487343e-07 / 4.37609121214664e-07 / 4.313448454057681e-06 / 4.476536711400614e-0673013 2.1997972567339213e-06 / 1.1288300480073834e-05 / 7.933567388992601e-06 4.70488E-06 13 50 PCDH17_2 0.0000000072 7.492219023207615e-07 / 1.6974372024295342e-05 / 1.6060512405884523e-05 / 3.680752556412065e-06 / 6.21390552863653e-07 / 6.893999398193879e-07 / 6.419532166056714e-06 / 0.00011541115360842292 / 3.212738000062656e-0584 603 e-05 / 1.030767276264569e-05 6.224247092494593e-07 / 1.908891295970431e-06 / 1.876118975664838e-08 / 6.86071862572385e-07 / 2.666345798254567e-06 / 2.440951781485953e-06 / 1.963413625423467e-06 / 2.0652089761761355e-06 / 1.494707065464428e-0614 8.28372335 7.600283334205516e-05 / 1.3148299792014698e-05 / 1.7938478170268224e-06 4.39826E-05 13 51 FCGRT_4 0.0000000001 1.6626318528356214e-07 / 4.1454120935946585e-08 / 1.2856777469915098e-05 / 2.655269050407992e-06 / 4.4947875774412546e-05 / 0.00076179506295693 / 8.948391869055381e-06 / 2.7424661803535043e-05 / 4.648680805728703e-06 / 1.91632420450747 06 / 2.5267554662269253e-05 / 6.405110910660664e-05 2.1372152215021398e-08 / 2.057088830240376e-08 / 5.269671774798225e-06 / 3.982312076585435e-06 / 2.495582032458844e-06 / 2.870333661857787e-05 / 9.483756578219822e-07 / 1.25762087754457e-05 / 9.76651146667424e-06 / 2.6617 1.3930567108132102e-05 / 1.1400150976360551e-05 / 2.349102225413189e-05 7.35514E-05 13 52 PPAPDC2_5 0.0000000000 4.5169034086855336e-09 / 9.742548139480632e-07 / 5.217506022585185e-05 / 3.5026216529567156e-06 / 2.4673093720667337e-06 / 5.3153783898022636e-05 / 1.3937823180284198e-07 / 7.982877170487641e-08 / 6.508221395478821e800 05 / 3.21116578085472e-05 / 6.01263079824308e-05 1.1212152252396135e-09 / 7.076208121664563e-08 / 4.726350666602277e-08 / 1.0531985708720735e-07 / 2.551343424529328e-06 / 1.7296428659338845e-05 / 2.9345983642597263e-07 / 8.883747046871617e-07 / 7.1695441364551825e9306 905 06 / 2.895020091940764e-06 / 9.487544302661349e-06 0.001561006 13 53 OTUD1_1 0.0000066678 0.0001143785517442608 / 7.116374713072327e-05 / 0.0013570458512569155 / 0.002178697316418811 / 0.0038052297192277813 / 0.0007240451812165356 / 0.0019400441864677392 / 0.0023946671170695885 / 0.011483919297924996 / 0.0019400441864677392 / 0.0011976310136393364 / 8.349404 2.4271728701188334e-07 / 2.716202606694871e-08 / 4.962003898295528e-07 / 1.3066402773912248e-06 / 2.94591397016505e-06 / 7.18702142240598e-07 / 1.4280279163673197e-07 / 7.547674557111806e-06 / 6.26163745905449e-06 / 6.44 5.452589541736924e-06 / 0.00036648972212703103 / 3.720187278061506e-05 0.002701445 13 54 IRS2_2 0.0000000037 7.220251902586713e-08 / 2.140496501618477e-08 / 1.0829140297466289e-09 / 4.1398213999064624e-06 / 1.5415033312027603e-05 / 1.1605014260398891e-06 / 3.934765724180659e-07 / 1.4279427966735553e-05 / 4.864296167501907e08 5.7336006475198166e-05 / 5.9617084438303865e-06 2.2709629567530206e-06 / 2.0247353106423544e-07 / 1.3837713193741096e-07 / 1.0531985708720735e-07 / 1.1721035444282598e-06 / 5.783428499209018e-07 / 1.1344098678195103e-05 / 1.301499532725973e-06 / 8.452688032747793e0606 3.0574198226347985e-06 / 4.1558712164911445e-06 1.02809E-05 12 55 AKAP7_1 0.0000000393 3.2501044823812903e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 1.615375160694009e-05 / 2.0071481202007584e-05 / 5.2109649171464235e-06 / 5.1570472200670454e-05 / 2.408755304649635e77705 1.765676819518555e-07 / 3.972296959609109e-08 / 3.2695301895520668e-06 / 1.5934388217060153e-05 / 3.721417159936691e-06 / 5.5785045280072256e-06 / 4.163536679627491e-06 / 5.719017833567702e-06 / 1.026744929609048e05 2.8764328668118886e-05 / 2.5301330015839306e-05 0.000155783 12 56 PCMTD2_1 0.0000000068 0.0003167991900078877 / 9.289397717877934e-06 / 9.224071980226081e-07 / 3.54688199707126e-05 / 3.2501044823812903e-07 / 2.408755304649635e-05 / 2.0071481202007584e-05 / 0.0006813940301036226 / 6.979794879972793e-06 / 0.0005120 167 905 5.861015607960784e-07 / 3.59230415078595e-07 / 6.529460316458851e-08 / 3.4690122473485e-07 / 8.012676260040657e-08 / 1.8059093721170035e-06 / 8.298018416641704e-07 / 9.470642017366756e-05 / 1.948928228321219e-06 / 2.35716 2.8538696820324185e-07 / 6.729556671438922e-06 0.000295734 12 57 ANXA11_1 0.0000005151 2.408755304649635e-05 / 9.224071980226081e-07 / 3.2501044823812903e-07 / 9.289397717877934e-06 / 0.004410274724633273 / 3.54688199707126e-05 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 0.0019333915490623197 / 4.559947799797 e-05 3.3435882766015197e-08 / 1.9719084534841054e-07 / 7.15064607927488e-08 / 6.417376094706333e-07 / 4.257425478509546e-06 / 1.5694978207696109e-06 / 3.888433936368708e-06 / 5.0965829347694e-07 / 3.057977557175645992-822e 3.6558508721641653e-06 / 2.5076660883555645e-06 0.000545266 12 58 CYP4F22_1 0.0000027180 1.887107728600381e-05 / 0.0001432193232982916 / 0.0003242200414121999 / 0.00011602560329098725 / 0.0001432193232982916 / 0.0010434554869778357 / 0.002087197919276702 / 0.0004963923899259765 / 0.0002441254991542676 / 0.006227948945630897 / 0.00011484315511043709 / 0.00021988598 1.855878357665062e-07 / 4.5205001853266315e-06 / 1.6230646465299277e-07 / 1.9937810791618053e-06 / 2.459173869598607e-06 / 1.418028686271357e-06 / 3.0798872921235664e-06 / 1.4638448696185004e-05 / 4.174632323174143e-06188 8.13226356593833e-06 / 4.0324998931408915e-06 0.000931617 12 59 FAH_1 0.0000000544 9.971939174478468e-05 / 0.0014783442733670397 / 2.051237402337122e-05 / 1.1263759452799203e-06 / 1.7999540459370774e-05 / 0.005398390884784092 / 0.0002944288613709527 / 0.0026702661426604127 / 0.0028963504457353837 / 0.0008619933402586445 1.0046436835312793e-07 / 3.154681248422513e-08 / 5.394104603263994e-07 / 2.7366646890842144e-07 / 5.480720006502052e-08 / 1.6335104962830753e-06 / 1.8420227314596207e-06 / 7.083329258820255e-06 / 2.102391157291273e0606 1.745e 0.00019992317018209673 / 1.9765391249129614e-06 0.001397921 12 60 PRSS35_1 0.0000001503 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 6.979794879972793e-06 / 5.2109649171464235e-06 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 2.408755304649635e-05906 0.011066537502725836 / 0.017443989828652796 2.153587369784463e-08 / 1.0035560526801471e-07 / 1.5112245406129175e-07 / 8.734069561342572e-09 / 6.456193736055655e-07 / 1.1915844331577668e-07 / 1.2496790707220447e-06 / 5.187593428631375e-06 / 7.677479865946060 2.4926729322946157e-05 / 6.095320536599329e-05 0.002384904 12 61 ARID2_1 0.0000000008 3.2501044823812903e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 5.1570472200670454e-05 / 1.3062838211579366e-05 / 2.7109747094287326e-07 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 6.979794879972793 3.54688199707126e-05 1.4085604923353669e-09 / 2.1559634977578997e-08 / 3.073451224470281e-08 / 6.67627891847618e-07 / 9.45287179820993e-07 / 1.6026605078229915e-06 / 2.8723110644674783e-07 / 6.593293352572093e-08 / 1.76044274336364e-06 / 4.083275206575873e-06 1.52054E-05 11 62 GBE1_2 0.0000000002 1.0829140297466289e-09 / 1.1605014260398891e-06 / 2.140496501618477e-08 / 2.4103457859893014e-05 / 1.3483681400210042e-06 / 6.882770012055959e-06 / 3.539399887995572e-05 / 4.926323640851737e-05 / 4.864296167507390706 4.1398213999064624e-06 6.14215099741482e-11 / 8.633691649398072e-08 / 3.1558675335691306e-07 / 6.649001393280087e-07 / 1.5766900825696111e-06 / 4.000342337039938e-06 / 2.5158332022026807e-06 / 1.3914120255170465e-05 / 3.7817976979062494e944 / 1.4262192253107675e-06 1.63761E-05 11 63 FEZF1_2 0.0000000048 2.140496501618477e-08 / 1.0829140297466289e-09 / 1.5415033312027603e-05 / 0.0006617980305097352 / 3.934765724180659e-07 / 4.864296167501907e-07 / 3.539399887995572e-05 / 7.220251902586713e-08 / 1.1605014260398891e14006 05 3.290701334443236e-08 / 5.517282972397794e-07 / 2.461670483939178e-07 / 3.7377331388541626e-05 / 5.142883274641414e-06 / 4.043272115285976e-06 / 2.938617309558263e-05 / 4.8239179614945364e-05 / 7.309372974198873e-06 / 1.0228531 2.3639654167207866e-05 6.72904E-05 11 64 ACACB_2 0.0000000003 2.135362618124217e-07 / 2.2402150648537843e-08 / 3.983245164121986e-08 / 4.136645421698625e-06 / 3.025796797872868e-08 / 0.0005588402339511055 / 8.584401402568793e-06 / 1.471749614726362e-06 / 0.0003892038851689398 / 3.89870447058717e 1.3484124764189522e-08 / 4.706709396786997e-07 / 9.271074896090571e-07 / 5.302698252478667e-06 / 2.0500342574990374e-06 / 1.551726788306523e-06 / 1.781550905952925e-05 / 7.047194494372442e-06 / 1.9709880947249853e-0627 1.1244039336708898e-05 8.83571E-05 11 65 CUX2_1 0.0000000906 0.0001432193232982916 / 1.887107728600381e-05 / 0.0003935478447180597 / 0.00033206653362091303 / 0.00021988598115354305 / 0.0001432193232982916 / 0.0007228851823325908 / 0.00036719870368562404 / 0.00011484315511043709 / 0.00011602560329098725 / 0.0004963923899259765 1.1673991664313873e-07 / 1.284325373822431e-07 / 1.6698077738985942e-06 / 6.902441910511023e-07 / 3.4215164228215663e-07 / 3.007835341834974e-06 / 1.919682119213592e-06 / 1.5381709053459223e-06 / 3.6946271417190457e 6.529025230777642e-06 0.000278923 11 66 H2AFY2_1 0.0000000422 0.0008581803853921776 / 1.1263759452799203e-06 / 2.051237402337122e-05 / 0.0031060111248571412 / 0.0005345324666238675 / 0.0001395680222164631 / 4.369070707050029e-05 / 9.971939174478468e-05 / 0.0003301911422383287 / 0.006072266622156599 / 0.00527944288613 5.135300319990053e-08 / 7.661142091219907e-10 / 7.618409522067726e-07 / 1.0083404706814497e-06 / 8.282189290342112e-07 / 1.147296721987914e-06 / 5.029041750177964e-07 / 2.8221672702900553e-06 / 6.87678977620963866e-06 / 1.681720206 1.5631172248405328e-05 0.001045475 11 67 SCNN1G_1 0.0000000555 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 6.979794879972793e-06 / 0.017443989828652796 / 2.0071481202007584e-05 / 5.2109649171464235e-06 / 0.0006200425273220967 / 9.224071980226081e-07 / 9.206396477 1.613539402686862e-07 / 3.7316428195760516e-08 / 6.371651336534961e-07 / 1.237673510094506e-06 / 6.701672901978117e-05 / 1.972791863813969e-06 / 1.1012098448593559e-06 / 1.967576698919758e-06 / 4.9444208073732495817 3.1007051507707384e-05 0.001646658 11 68 MICAL2_1 0.0000002288 0.00049387566368266 / 8.019236578134864e-05 / 0.004971246918927329 / 0.004078510310946084 / 0.0004290110230937398 / 0.00043106377145357623 / 0.0006315592529035093 / 0.001914379403049941 / 0.0034656404808317003 / 0.0025176594807100345 / 0.00031707617750638764 2.1762204790117787e-09 / 3.2272833090138044e-07 / 7.827762172740352e-08 / 6.06643046842526e-08 / 1.3129367317358875e-07 / 4.830225730426315e-07 / 3.928902637745179e-07 / 3.9101702420209316e-06 / 9.84639797132252e-07 / 6.086407 2.1279294679682064e-06 0.001757292 11 69 SWT1_2 0.0000000170 2.9659818641279015e-06 / 0.00029176699231122706 / 1.5046470240543167e-06 / 0.004644223206500837 / 0.010900569633432996 / 2.7522055206568103e-06 / 0.00013583448483780612 / 0.004741348922243877 / 0.0003486124797281799 / 7.371030323660905e-9559 4.9187331773462e-08 / 2.5012881769902937e-08 / 6.268977803019969e-07 / 1.3528096310298506e-06 / 2.783451231831402e-06 / 2.565078990567409e-07 / 8.86664377274927e-07 / 5.964528017547677e-07 / 6.174004769239488e-07 / 1.0484586327302643e-05 0.001938646 11 70 PDE6B_1 0.0000013889 1.228676574562544e-05 / 0.0011323441860117745 / 8.807499017205126e-05 / 0.002107325343692074 / 0.0014854545690578267 / 0.019751746709410014 / 0.004410274724633273 / 0.005133998810813905 / 0.0020170234515396526 / 0.004410274724633273 / 0.0016232581034909483 5.065661868983875e-07 / 7.17995131525044e-07 / 4.053723016913819e-06 / 8.937583768343871e-07 / 1.1790960971280032e-06 / 4.154079216411671e-06 / 1.726041894379202e-05 / 1.0279309246897823e-05 / 0.0003143462985658605331 05 0.003833824 11 71 FUT11_4 0.0000000000 6.74235053631547e-08 / 4.771768758103407e-07 / 3.1959674906838326e-06 / 1.3575216074689785e-06 / 1.8241579597627434e-05 / 8.479913437625553e-06 / 8.284064752711457e-06 / 0.00018644210000651158 / 5.006828327534464e-05 / 8.236105250 2.4685536420123714e-08 / 4.05022735179046e-08 / 8.733965575196973e-08 / 1.3604574320151334e-07 / 8.805480517015095e-07 / 2.385334687979164e-07 / 4.9124234903367736e-06 / 9.92600195563702e-06 / 3.057977557175645e-06 / 1.118638657 2.8485E-05 10 72 CRMP1_2 0.0000000000 2.0535846739106096e-05 / 1.3401582342156554e-08 / 2.225580423517811e-06 / 1.3942380334535833e-06 / 0.00024560379848655926 / 4.659755401849588e-08 / 2.1627385395830295e-05 / 3.633081984870721e-07 / 3.4192931304829014e-068549787939 7.620811819896486e-06 / 4.382658462880079e-06 / 1.3863143636682347e-05 / 1.3319999198783528e-06 / 1.2152438530817433e-05 / 4.382658462880079e-06 / 8.241971999095359e-06 / 9.923377128421226e-06 / 6.249002717536056e-06 / 5.602505 9.83169E-05 10 73 ATP2B3_2 0.0000000043 0.0003163773097135214 / 7.172518710454511e-06 / 7.245191987655973e-05 / 8.741819060152168e-05 / 5.359794419137135e-05 / 4.430782193013355e-05 / 0.00023847763377654726 / 4.824032561244295e-06 / 4.5251992585881006e-07 / 0.00049496597238 2.4865375915662647e-06 / 1.5062494177669247e-06 / 1.688540465706646e-06 / 1.6196306143315863e-06 / 2.748486185526218e-07 / 2.086193436943505e-05 / 2.6861282329371614e-06 / 5.547613575367754e-06 / 3.303970125073177e-05 / 15238 0.000132005 10 74 KLHL23_2 0.0000000192 6.893999398193879e-07 / 6.419532166056714e-06 / 2.702881264505673e-05 / 6.21390552863653e-07 / 0.0017884623559603927 / 1.6974372024295342e-05 / 0.001013875347197311 / 7.396819433180742e-05 / 0.0005052900676961513 / 7.73108993084 4.968239365259682e-09 / 1.7135370925414656e-07 / 2.932867120091765e-07 / 3.3425571794650135e-07 / 3.0548311202804935e-06 / 3.451257716664588e-06 / 2.1699721245824695e-06 / 4.163536679627491e-06 / 2.920396755301379e657 0.000344106 10 75 PNMAL1_1 0.0000000001 9.224071980226081e-07 / 9.289397717877934e-06 / 3.54688199707126e-05 / 8.058554843717415e-06 / 2.408755304649635e-05 / 2.7109747094287326e-07 / 4.491442887170463e-06 / 3.54688199707126e-05 / 0.003763661611010697 / 2.00714812020084 2.398130659400807e-08 / 3.3728825978612466e-08 / 2.556768800894887e-07 / 1.098753545263955e-07 / 8.352881705441376e-07 / 4.562304305269522e-07 / 1.08096832891062e-06 / 1.1362044976111473e-06 / 3.965156059753076e-06 / 2.5325448 0.000390179 10 76 DPP9_1 0.0000000903 0.0001432193232982916 / 0.009103599585178113 / 0.001710012299865077 / 0.00011602560329098725 / 0.0004963923899259765 / 0.0002441254991542676 / 1.887107728600381e-05 / 0.00021988598115354305 / 0.00033206653362091303 / 0.00011484315511043709 2.8179456082348394e-09 / 2.727075953865357e-06 / 1.168813758935927e-06 / 3.371222633783479e-08 / 4.426276839356633e-07 / 7.736320976296901e-08 / 1.0399111877082387e-07 / 5.1926198984756595e-08 / 2.443030575808895e08 0.001249904 10 77 GPC2_1 0.0000011913 0.00038318838044808375 / 0.0005893191501630695 / 0.00015165886425239433 / 0.0001877376372184388 / 7.79155859315203e-05 / 3.4006794328894204e-05 / 9.771266164691155e-05 / 0.0021345675385303783 / 0.009896861713608592 / 0.00046672125625950257 5.8322357175018814e-08 / 3.819394841783607e-06 / 4.185755315703245e-06 / 8.9047725673033e-06 / 1.688540465706646e-06 / 1.3977429686239098e-06 / 7.632716224230066e-06 / 2.3986226430486996e-06 / 8.321983027984269e0505 0.001401969 10 78 RBM27_1 0.0000328921 0.00019056149396649567 / 1.0762691116666793e-05 / 0.00016655530309410099 / 0.00014532888285824017 / 0.008666672397448167 / 0.0011926586521531122 / 8.547883129077166e-06 / 0.0005615344938163923 / 0.0009516879673421394 / 0.008666672397448167 3.272103105129996e-05 / 6.146543343371357e-05 / 3.6952686083686934e-05 / 1.4957676302550525e-05 / 0.00044169721387816736 / 0.0002538625473566664 / 6.352688846998858e-05 / 0.00045432042455129443 / 0.0011408393624126037 / 4.513400088366357e05 0.002056098 10 79 HOXD13_1 0.0000000916 2.7109747094287326e-07 / 3.2501044823812903e-07 / 3.1219185299958266e-05 / 0.0027465190930067913 / 0.017443989828652796 / 0.016412811603890378 / 9.224071980226081e-07 / 0.0006813940301036226 / 5.2109649171464235e-06 / 9.289397717877934e06 1.1132672619587453e-06 / 2.168405947503928e-06 / 8.632653046332761e-07 / 2.661765393750704e-07 / 2.9706339258865287e-05 / 9.772801528529325e-07 / 6.119157345497534e-06 / 4.403524887759186e-05 / 3.9616874289254276e05 0.003733195 10 80 TFCP2_1 0.0000155106 0.0032558342640986913 / 0.003164163749771866 / 0.007834759439000943 / 0.0006574116836031526 / 0.0004120327968848806 / 0.002547330192150467 / 0.023671720746870278 / 0.01008298563196674 / 0.003825348546364798 / 0.012865293420775923 1.7408199559491215e-08 / 3.662770588769913e-08 / 2.4230602059049713e-09 / 7.057607420139844e-09 / 5.864919427085214e-09 / 4.067269852743229e-09 / 1.2958775867702838e-07 / 2.4061415002001486e-07 / 1.04445857509862e-08 / 8.40682633 0.006831688 10 81 MLC1_2 0.0000000000 2.3317798357459768e-08 / 3.950726068803937e-05 / 7.200240759113992e-08 / 6.485065795284483e-06 / 2.72061163246224e-07 / 1.0914465968113564e-09 / 8.785255275890593e-07 / 2.260908840956264e-06 / 3.4091273206128115e-06 3.821355197181773e-10 / 4.815234643922553e-08 / 4.880618111292151e-07 / 6.535686301472137e-07 / 5.01553847742357e-09 / 9.071527094231567e-07 / 1.561363617000177e-06 / 3.5739771593065375e-08 / 6.799019141310347e-07 5.87882E-06 9 82 NUDT10_1 0.0000000252 5.2109649171464235e-06 / 2.0071481202007584e-05 / 1.3062838211579366e-05 / 5.2109649171464235e-06 / 3.54688199707126e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 6.979794879972793e-06 / 4.559947241482223e05 8.543772901530404e-08 / 3.0560088249163646e-06 / 3.4630204183867344e-06 / 1.75703491771623e-06 / 8.596645616376963e-06 / 6.6659679642121145e-06 / 6.998717296179836e-06 / 6.1225414982440546e-06 / 6.176627272024636e-05 1.57573E-05 9 83 ABHD6_5 0.0000000011 3.358358494818591e-05 / 2.9134927252228483e-07 / 2.9938150702443185e-06 / 2.052332708446901e-06 / 1.4490238008299036e-06 / 3.2017228485917034e-06 / 7.134949223903302e-05 / 9.16995079558899e-05 / 3.381829650307869e05 1.889438601616299e-06 / 1.2766781385500044e-06 / 2.363524198350829e-06 / 3.917011825001329e-06 / 7.303755032082717e-06 / 1.3315374780889495e-05 / 2.4860974232140882e-05 / 1.6960856788042183e-05 / 1.807142776332772e05 2.67155E-05 9 84 NDST4_2 0.0000000040 2.668064610627935e-06 / 6.6526771052306895e-06 / 1.1230314579614556e-05 / 1.8473033200489925e-05 / 6.627915836434039e-07 / 8.256090054064686e-05 / 1.116884259988551e-05 / 5.25757451328789e-05 / 9.075192641901149e-05 9.235058235332018e-08 / 3.739290293217579e-07 / 8.778520319265194e-07 / 4.805213523603749e-07 / 9.024033737327827e-06 / 1.2463662086892492e-06 / 2.593919669520066e-06 / 1.5869215394518834e-05 / 6.9327764685965786e-06 3.07494E-05 9 85 POU3F2_5 0.0000000000 7.323883195296019e-07 / 5.815521557860219e-06 / 1.9482696423142906e-05 / 0.0007454381092335746 / 1.161047392436168e-05 / 1.810779009958944e-06 / 4.647086083767663e-06 / 1.4526839867076841e-05 / 3.820854417705018e-05 4.118783678942697e-07 / 1.9018218973456198e-06 / 5.1834489629063885e-06 / 0.00016912370949213852 / 1.1280051635983909e-05 / 3.251853365907979e-06 / 6.769433778371573e-06 / 2.785132091011529e-05 / 7.035159184655411e-05 9.35858E-05 9 86 RND2_1 0.0000002063 3.2501044823812903e-07 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 2.408755304649635e-05 / 0.0003167991900078877 / 9.289397717877934e-06 / 9.224071980226081e-07 / 0.0006200425273220967 / 0.0019333915490623197 4.692355741850912e-08 / 3.057428987575251e-08 / 1.287838376941801e-06 / 6.249875151319963e-07 / 2.5823199743834396e-06 / 2.0615635366014647e-06 / 1.0191814256901842e-06 / 1.8943189562108068e-06 / 2.0339342639032117e05 0.000325095 9 87 TEKT2_1 0.0000012269 3.2501044823812903e-07 / 0.00299921656722761 / 2.7109747094287326e-07 / 6.979794879972793e-06 / 9.224071980226081e-07 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 9.289397717877934e-06 / 0.0019333915490623197 2.626807545548127e-07 / 8.972858217500653e-07 / 8.188038459526457e-05 / 1.2353713533928581e-05 / 4.657480324879461e-05 / 6.734781530483014e-06 / 3.917368514292802e-05 / 4.398198496660895e-05 / 3.85813042649088e-05 0.000552853 9 88 RCOR1_1 0.0000002629 0.0035374364838401885 / 0.0005794708000429308 / 0.004598611207763406 / 0.00027838639004009185 / 0.00254170936910902 / 0.0007730790428095843 / 0.0008116048904747243 / 0.00028760490535839194 / 0.0006209741142612609 2.12095972377237e-08 / 5.371804546576567e-07 / 1.3631627975922064e-06 / 1.3930567108132102e-05 / 7.320109762709196e-06 / 3.5012227758823163e-06 / 9.972925901562962e-06 / 5.848283608879877e-06 / 1.9939940203933426e-05 0.001558764 9 89 SH3GLB1_1 0.0000001142 1.1263759452799203e-06 / 0.0002944288613709527 / 1.7999540459370774e-05 / 0.009181416163184238 / 0.0001249119186090808 / 0.001133267650419163 / 0.0026702661426604127 / 0.005398390884784092 / 0.00014547367344876742 5.021137237572428e-08 / 1.412114735889678e-07 / 2.6082574074268862e-06 / 2.1694530129992346e-06 / 2.622668544008386e-06 / 1.3863143636682347e-05 / 2.2950455177001124e-05 / 8.882430105407664e-06 / 8.761908558227523e-06 0.002107476 9 90 ZCCHC5_1 0.0000003387 0.0002944288613709527 / 0.004641723683002966 / 0.00036105139567184824 / 0.0036790499750236597 / 0.0005345324666238675 / 0.0021653473543332357 / 0.0067509647795811235 / 0.0033178709219427965 / 0.0001395680222164631 2.1634030409586368e-05 / 1.0447439952129488e-05 / 4.841492876651217e-06 / 8.425020418700623e-06 / 1.7550566576642783e-06 / 1.829374010437789e-05 / 0.00016237480333105512 / 2.4267895369009183e-05 / 1.021655106614923e-05 0.002431615 9 91 EVI2B_1 0.0000000810 0.0005654433700885616 / 0.0021345675385303783 / 0.0010514734188248587 / 0.01706732677471782 / 0.00016882475928990226 / 0.0017046060667733898 / 1.7173658335771082e-06 / 0.0010760707198761224 / 0.01365229997365103 4.967070750533046e-07 / 9.339254057047784e-06 / 2.37004080182631e-05 / 1.7573172310813478e-05 / 4.067330085914587e-07 / 1.0577974069325492e-06 / 9.173510310512699e-06 / 1.887257789753108e-05 / 6.115093766942535e-05 0.004158037 9 92 EPC1_2 0.0000000072 0.0034390541604176214 / 0.0002448208689788285 / 0.01617199881991826 / 0.02211371791626479 / 0.0025035638269418226 / 0.01851025775546256 / 0.006305703578524486 / 0.00515664879236201 / 0.009067920198647179 5.695617165978249e-07 / 1.1672960349256724e-07 / 2.840596912722915e-06 / 6.081404109618168e-06 / 2.4211525355218317e-06 / 1.1016073014221325e-05 / 1.0934695006353887e-05 / 4.4117963688512546e-05 / 2.106616906903645e-05 0.009279298 9 93 VAX1_2 0.0000000005 1.3401582342156554e-08 / 4.659755401849588e-08 / 4.835640776889601e-06 / 7.359704703027111e-07 / 1.096889887353167e-06 / 1.3942380334535833e-06 / 5.207246052888057e-07 / 3.4192931304829014e-06 7.755118664932962e-08 / 9.171116579440387e-08 / 1.1013084399854174e-05 / 4.524910966526263e-06 / 1.529385415217493e-06 / 1.427223677524831e-05 / 1.4066320814267013e-05 / 2.2774582231147903e-05 1.50784E-06 8 94 DLG2_3 0.0000000002 7.813308929582946e-09 / 1.6547061876174137e-09 / 1.3841014381780992e-08 / 3.911794473620475e-08 / 3.925563562928499e-06 / 1.0025262671531361e-05 / 1.4592559377242048e-06 / 7.203525855071736e-08 5.333355940483967e-07 / 2.493514693804668e-05 / 1.3553742801395556e-05 / 2.784723823441103e-05 / 0.00031844709703193725 / 3.540970687955017e-05 / 4.292537092544752e-05 / 4.4176636548796324e-05 1.94307E-06 8 95 PPP1R1A_2 0.0000000058 6.21390552863653e-07 / 6.893999398193879e-07 / 7.492219023207615e-07 / 2.702881264505673e-05 / 3.680752556412065e-06 / 1.6060512405884523e-05 / 7.73108993011784e-06 / 6.419532166056714e-06 2.1597799174876656e-06 / 1.9305294911280603e-06 / 5.352949078223872e-06 / 6.799175330608916e-06 / 8.452688032747793e-06 / 1.5945569790774137e-05 / 3.22477346098806e-05 / 2.984896137178954e-05 7.87259E-06 8 96 EFNB1_1 0.0000000276 2.7109747094287326e-07 / 6.979794879972793e-06 / 9.224071980226081e-07 / 4.0242980256377906e-05 / 3.2501044823812903e-07 / 0.0004073113752386311 / 5.2109649171464235e-06 / 4.559947241482223e-05 2.1957511801277782e-07 / 4.889428996554765e-08 / 2.1248474074975664e-07 / 1.7135370925414656e-07 / 3.884450294793579e-06 / 5.591633483860606e-06 / 1.8857958946421756e-06 / 2.8107942340015973e-05 6.33579E-05 8 97 POU3F1_2 0.0000000002 1.0829140297466289e-09 / 2.140496501618477e-08 / 0.0006617980305097352 / 3.539399887995572e-05 / 1.1605014260398891e-06 / 4.1398213999064624e-06 / 4.864296167501907e-07 / 1.3483681400210042e-06 6.030358521257982e-09 / 1.7387409176294374e-08 / 5.254390767028075e-06 / 2.543218750177778e-06 / 1.6396573544351217e-06 / 8.529464444824402e-07 / 6.695092024209846e-06 / 8.770352824154869e-06 8.80437E-05 8 98 JPH1_2 0.0000000087 5.556780192800504e-08 / 2.0874526624748995e-06 / 0.0012644399858917665 / 4.607960729596523e-06 / 2.1738520362230936e-05 / 1.6503521660931074e-06 / 2.1738520362230936e-05 / 0.00015574282021503215 3.4277179006258406e-08 / 1.490529071824182e-08 / 3.286947652963165e-05 / 8.194195146930721e-06 / 2.1888678883833245e-05 / 2.6787516426543844e-06 / 1.2909385190385643e-05 / 1.5296407537085686e-05 0.000184008 8 99 LGALS3_5 0.0000000000 0.0003565042040229888 / 9.438944028750308e-06 / 9.04485841302387e-07 / 1.6632151970584391e-06 / 3.410158051548764e-05 / 0.0003318801877935931 / 0.0012804486516771864 / 0.00021733046754869307 6.677920897376901e-06 / 2.6764509283677262e-06 / 1.8682268381796687e-06 / 7.156112560189961e-06 / 5.102936564089435e-05 / 1.756292794705785e-05 / 9.025855388190028e-05 / 1.637569955003e-05 0.000279034 8 100 LRRC4B_1 0.0000002709 1.887107728600381e-05 / 0.0005437871552770366 / 0.0001432193232982916 / 0.00011602560329098725 / 0.00021988598115354305 / 0.0007228851823325908 / 0.002087197919276702 / 0.0004963923899259765 5.474742848216316e-08 / 7.540000372679234e-08 / 2.4324836459725464e-07 / 1.1863961735006869e-06 / 1.582805196129757e-06 / 3.4634781029298443e-06 / 3.0574198226347985e-06 / 7.803003903662519e-07 0.000543533 8 101 ARHGAP19_1 0.0000004900 1.1263759452799203e-06 / 0.0002944288613709527 / 2.051237402337122e-05 / 0.00014547367344876742 / 0.0003301911422383287 / 0.0001395680222164631 / 0.0026702661426604127 / 0.006072266622156599 8.088262923201297e-10 / 5.32512126526287e-09 / 8.298236021731966e-08 / 3.5084952233067013e-07 / 2.3265577637109093e-06 / 1.1001720936904985e-06 / 3.6392711556668255e-06 / 1.2562017250662189e-06 0.001209229 8 102 MYL9_1 0.0000000778 9.224071980226081e-07 / 5.2109649171464235e-06 / 2.7109747094287326e-07 / 1.3062838211579366e-05 / 9.289397717877934e-06 / 5.2109649171464235e-06 / 3.2501044823812903e-07 2.459173869598607e-06 / 3.652101302901246e-06 / 1.2972527217084128e-05 / 8.597378090854104e-06 / 5.7833188092788925e-06 / 1.4022276300344631e-05 / 2.145854408813797e-06 4.89895E-06 7 103 TMEM170B_1 0.0000002606 9.289397717877934e-06 / 9.224071980226081e-07 / 3.2501044823812903e-07 / 2.0071481202007584e-05 / 4.559947241482223e-05 / 2.408755304649635e-05 / 5.2109649171464235e-06 1.9697921819906958e-07 / 3.165978824218861e-07 / 2.2816438659720932e-06 / 2.742836199391347e-06 / 6.990510977409468e-05 / 2.9323575212698406e-06 / 8.993575247920803e-05 1.50723E-05 7 104 CSAD_1 0.0000002822 5.2109649171464235e-06 / 3.54688199707126e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 3.54688199707126e-05 / 2.0071481202007584e-05 / 6.979794879972793e-06 6.111203426085803e-07 / 2.171879517260808e-06 / 5.854820901741727e-07 / 7.835058995288738e-07 / 2.7557290434491165e-06 / 6.817652862377265e-07 / 1.2092985656812561e-05 1.62017E-05 7 105 ASGR1_5 0.0000000000 1.1623489088470996e-07 / 3.721066145469274e-07 / 3.333239304736607e-06 / 2.1608013080506192e-07 / 3.230485829869497e-05 / 8.060189282236343e-06 / 8.676969132083257e-05 7.305647078744524e-09 / 5.144455443656822e-07 / 1.4357703259269896e-06 / 1.2509260043210937e-08 / 5.934720152286974e-06 / 2.2212849303091722e-05 / 1.856219255522198e-05 1.87389E-05 7 106 KIAA1958_1 0.0000014113 9.224071980226081e-07 / 3.2501044823812903e-07 / 9.289397717877934e-06 / 2.0071481202007584e-05 / 0.00029640089162746337 / 1.3062838211579366e-05 / 2.408755304649635e-05 1.7837147826607992e-06 / 6.377999497501375e-07 / 6.986597395696305e-07 / 2.0980658004722796e-06 / 1.9921322770288805e-06 / 1.773331235256366e-05 / 5.3250557763788615e-06 5.20228E-05 7 107 NPW_2 0.0000000041 3.24920563754477e-05 / 1.6676618048371524e-06 / 3.349324237754571e-06 / 0.00026033133118006545 / 2.8198901661861037e-07 / 1.3377106429420062e-05 / 0.00015487870247863725 1.1216334102038042e-05 / 3.795870398901593e-05 / 2.789700527592356e-05 / 2.4370350557859375e-05 / 2.383281576252229e-06 / 1.739637519533283e-05 / 4.995051896804675e-05 6.66255E-05 7 108 CAP1_1 0.0000001084 3.2501044823812903e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.408755304649635e-05 / 5.1570472200670454e-05 / 0.0006813940301036226 / 1.615375160694009e-05 2.3269670797546372e-09 / 2.178989287248064e-07 / 1.5690808649462252e-07 / 2.2812382420261574e-07 / 5.003267757352306e-07 / 5.854077230406485e-06 / 3.5713716118086355e-06 0.000111963 7 109 SIAH3_1 0.0000003288 2.7109747094287326e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.408755304649635e-05 / 3.2501044823812903e-07 / 1.615375160694009e-05 / 0.0019333915490623197 6.049342679130285e-07 / 8.815712638887937e-06 / 4.740549194395327e-06 / 9.480468782335477e-06 / 1.5820053502878103e-05 / 6.463404069739772e-06 / 1.6126637325555423e-05 0.000283492 7 110 PALM3_1 0.0000000299 1.1263759452799203e-06 / 0.00014547367344876742 / 0.0002944288613709527 / 6.267778266652492e-05 / 0.00036105139567184824 / 4.369070707050029e-05 / 0.0012393227037226365 1.61127559567575e-08 / 5.017834401276047e-07 / 3.661929862620404e-06 / 1.2173443563611742e-05 / 1.1966193354414176e-05 / 2.4195118600922182e-05 / 1.7243254719929916e-05 0.000306824 7 111 STMN3_1 0.0000000026 7.246316173948605e-05 / 3.547654313435299e-05 / 0.0009373528710364089 / 0.0006480090460888989 / 0.0006480090460888989 / 0.0006480090460888989 / 0.0003279301515605841 7.322406775875832e-06 / 8.942892958849265e-06 / 1.807142776332772e-05 / 2.509219654843992e-05 / 1.8505484636417077e-05 / 3.37731892462157e-05 / 9.285668025091915e-06 0.000473893 7 112 TMEM81_1 0.0000008765 5.273896379563962e-05 / 6.356656086987109e-05 / 0.00043134694416039135 / 0.00013546030217733798 / 0.0004059772887267331 / 0.0023391751758116753 / 0.00032373731095170963 1.0787679920477812e-07 / 2.5789707372412023e-07 / 2.2840059569727543e-06 / 3.5876629179259e-06 / 1.224552952677817e-05 / 1.3699807790719473e-05 / 0.00010021610177229421 0.000536 7 113 SPATA6L_2 0.0000000000 6.561438181488045e-08 / 0.0039060792371246288 / 1.2713340125393577e-06 / 4.9709559427158936e-05 / 2.9984630262222775e-05 / 2.5044323053359897e-05 / 0.0003189222745634422 1.1928730580085498e-07 / 1.6308994378745635e-05 / 7.252465307108788e-07 / 4.675129100784084e-05 / 2.4918595616148034e-05 / 1.2527391630040111e-05 / 0.00035139543234848433 0.000618725 7 114 CSRP2BP_5 0.0000000001 0.0010693215114176687 / 0.0005366621924321155 / 5.114637961482107e-05 / 0.001965268902490897 / 0.0006502221049801445 / 1.6105294963590637e-05 / 0.0010730574005743563 3.1276785123692046e-07 / 9.71112422824034e-07 / 6.485117187559721e-06 / 9.024033737327827e-06 / 2.832326930093088e-06 / 4.687104252350739e-07 / 1.9659786069911358e-05 0.000765969 7 115 MAP2K6_1 0.0000003962 0.00049387566368266 / 0.001914379403049941 / 0.0025176594807100345 / 0.0006315592529035093 / 0.0034656404808317003 / 0.00043106377145357623 / 0.004971246918927329 1.1930754029013138e-06 / 8.239304675009157e-06 / 9.456559403963851e-07 / 1.224552952677817e-05 / 1.1431401687645685e-05 / 4.3734040668837504e-05 / 2.2586038013431965e-05 0.002060775 7 116 HOXB13_1 0.0000005163 3.2501044823812903e-07 / 0.011066537502725836 / 9.289397717877934e-06 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 0.017443989828652796 / 1.615375160694009e-05 2.2857725793381497e-08 / 6.58231193542836e-07 / 9.335221622816497e-07 / 5.9574734192841e-07 / 9.009609250490209e-07 / 6.752637204404786e-06 / 6.717516905544411e-06 0.004079613 7 117 RBM12B_1 0.0000027010 0.04720120118838744 / 0.01326934306028551 / 0.016928162681653376 / 0.031078733529297287 / 0.002048221708938053 / 0.0034110277620841853 / 0.0010661050941684071 2.1680661197087e-06 / 2.9189015908569146e-07 / 1.1699094105987198e-06 / 7.252465307108788e-07 / 7.978099824844419e-07 / 9.884000914674844e-06 / 2.094766018419809e-07 0.016428971 7 118 ADRB3_1 0.0000000110 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 2.0071481202007584e-05 / 9.289397717877934e-06 / 9.224071980226081e-07 4.241171654391019e-07 / 1.460759694934436e-06 / 1.0275041110630902e-05 / 2.951788675228993e-05 / 2.7256307870565235e-06 / 1.7536333634491446e-06 5.3003E-06 6 119 LUC7L_5 0.0000000000 4.893976636572636e-08 / 4.301553480101108e-06 / 1.9454781373606418e-07 / 2.401972521996653e-06 / 2.7416809858149543e-05 / 2.126445195983224e-06 9.243344747900569e-10 / 5.575865427598105e-07 / 7.332853758502689e-07 / 1.804034226196658e-06 / 3.3436666464536245e-05 / 5.494452455047808e-06 6.08171E-06 6 120 ITM2A_1 0.0000000846 2.7109747094287326e-07 / 3.2501044823812903e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 5.2109649171464235e-06 / 4.0242980256377906e-05 9.57143021581257e-08 / 2.3530982511650296e-08 / 9.277238538824435e-08 / 9.772375417317643e-08 / 7.542510909686565e-07 / 5.344419818471506e-07 8.99204E-06 6 121 ICAM4_1 0.0000001503 3.2501044823812903e-07 / 9.289397717877934e-06 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 3.1219185299958266e-05 / 2.7109747094287326e-07 6.095674277276536e-08 / 1.9332727891019487e-07 / 1.5381709053459223e-06 / 2.6680204178603233e-06 / 3.8772692803359075e-06 / 2.7997676176494448e-05 1.03498E-05 6 122 HMCN1_1 0.0000002057 9.224071980226081e-07 / 6.979794879972793e-06 / 3.2501044823812903e-07 / 2.0071481202007584e-05 / 3.54688199707126e-05 / 2.7109747094287326e-07 2.325888657256971e-08 / 7.057956530849985e-08 / 4.408357829435433e-07 / 3.236174072045171e-07 / 2.3836720647269927e-06 / 1.2257808319403609e-05 1.06731E-05 6 123 ZNF397_4 0.0000000000 1.1490697075516314e-07 / 5.267608369882088e-05 / 2.6997110563148354e-05 / 1.1548564870533097e-06 / 2.0333256661723552e-08 / 5.997442187105882e-06 1.209273134002773e-07 / 2.356993671060887e-07 / 1.889438601616299e-06 / 4.5197938838389625e-07 / 1.0616232919691243e-07 / 1.1196923674745125e-06 1.44935E-05 6 124 DRAP1_1 0.0000000328 2.408755304649635e-05 / 9.289397717877934e-06 / 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 5.1570472200670454e-05 1.8161954541326127e-08 / 2.3467711706414707e-08 / 7.39840605537318e-08 / 9.681901028699171e-08 / 6.251568155356543e-07 / 7.07965550831983e-07 1.77111E-05 6 125 DTX3L_1 0.0000000920 2.408755304649635e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 3.2501044823812903e-07 / 3.54688199707126e-05 / 5.1570472200670454e-05 3.2169896739895314e-07 / 6.548683737212715e-07 / 1.9632962963789034e-07 / 8.23683137309925e-07 / 1.3384906301502949e-06 / 3.688500356447034e-06 2.02773E-05 6 126 NUDT11_5 0.0000000000 2.520077460838455e-06 / 0.00019847043212428944 / 9.212731853638905e-06 / 5.327685852957849e-05 / 7.074807022331135e-06 / 5.506319326881712e-06 6.030864046314226e-07 / 5.4148978375789446e-05 / 4.298503068923771e-06 / 4.6387467002391374e-07 / 3.113591613373381e-06 / 2.237597740187554e-06 4.60102E-05 6 127 ADAM19_3 0.0000000000 0.00014925747204187325 / 2.926784989427661e-05 / 3.9436377050004215e-05 / 8.350382499334708e-05 / 9.099838750221392e-06 / 0.00012689846158790022 4.429367557026339e-06 / 3.859292848839367e-07 / 7.371158036631407e-06 / 3.558113101675235e-06 / 1.737907854441337e-05 / 1.0224109644328716e-05 7.29106E-05 6 128 HS3ST4_2 0.0000000267 4.981322036893917e-06 / 2.606975599460185e-05 / 8.565659227788306e-05 / 0.0002754556536102276 / 7.209835341373319e-05 / 3.152964683173717e-05 1.1012098448593559e-06 / 1.1675757440124896e-05 / 1.5407255327564443e-05 / 1.049514284917264e-05 / 1.031858123131195e-05 / 0.0001438654836752122 8.26319E-05 6 129 CRIPAK_4 0.0000000000 0.00015414987039053912 / 0.00011823367623626102 / 0.0009189200604961089 / 0.0007149452063580587 / 0.0006845676304155839 / 0.00041005648424125555 2.245806750816546e-06 / 4.7163754949833893e-07 / 2.309187383213676e-06 / 1.0481115140245655e-05 / 1.5648091897413959e-06 / 2.123855035553147e-06 0.000500145 6 130 OLFM3_1 0.0000002915 1.1263759452799203e-06 / 9.971939174478468e-05 / 2.051237402337122e-05 / 0.0001395680222164631 / 0.0028963504457353837 / 7.924407878618111e-05 2.6837870218219574e-09 / 3.561518617190357e-08 / 1.882754136330223e-07 / 1.470434762035522e-07 / 3.069489887698277e-07 / 4.200340993458125e-06 0.00053942 6 131 LMO2_4 0.0000000000 1.3505056742555753e-05 / 1.1618150079504721e-07 / 0.00013064212236741545 / 4.111357296377365e-06 / 0.0035192650416157674 / 4.781143220313644e-05 2.1639192493163854e-06 / 1.7833831305356847e-07 / 2.620411019163743e-06 / 2.1101434315006795e-06 / 2.7275081013397453e-05 / 1.3040674962690977e-06 0.000619242 6 132 SALL2_1 0.0000003934 1.1263759452799203e-06 / 0.0038265104822853674 / 2.051237402337122e-05 / 0.0002944288613709527 / 0.0008581803853921776 / 0.00014547367344876742 1.6243939304465606e-09 / 9.280889011804578e-07 / 7.466764406748627e-07 / 6.300687009130246e-07 / 1.0493357935620423e-05 / 9.50907155614804e-07 0.000857705 6 133 SLC35F3_1 0.0000002146 0.0008619727380490119 / 0.004410274724633273 / 8.807499017205126e-05 / 0.0007073001228128905 / 1.228676574562544e-05 / 0.002107325343692074 4.661997914978101e-07 / 8.34478701501445e-07 / 8.627333575428783e-07 / 1.0961759232568219e-05 / 1.5605455965805294e-06 / 4.962489165357357e-06 0.001364539 6 134 RHOH_1 0.0000001993 1.887107728600381e-05 / 0.0001432193232982916 / 0.0002441254991542676 / 0.0020865035640383737 / 0.006227948945630897 / 0.00021988598115354305 8.908782275302052e-08 / 1.3002938709565544e-06 / 8.336014361253352e-07 / 1.0527458641807459e-06 / 1.1820153415714242e-05 / 2.4865375915662647e-06 0.001490092 6 135 MED23_1 0.0000009756 0.0007073001228128905 / 0.0011323441860117745 / 0.004410274724633273 / 0.0010325370165401593 / 0.002107325343692074 / 0.0016226906289916678 1.0975653631511024e-07 / 1.045969028083387e-07 / 6.416985820926155e-07 / 1.5558825628623162e-06 / 8.122287757832368e-07 / 1.1607897314120871e-06 0.001835412 6 136 ALS2CR8_2 0.0000000009 0.0006315082871911089 / 0.0005431426189626602 / 0.0021396275484352 / 0.026018702566094058 / 0.001000241728120363 / 0.0003308344387923977 1.2953287867816182e-06 / 3.495208827896601e-06 / 1.6445250431991489e-06 / 2.13746074336515e-05 / 1.4749418379777713e-06 / 1.7906341936525482e-06 0.005110676 6 137 PDS5B_1 0.0000000930 0.009896861713608592 / 0.020827775351599746 / 0.0012471395414138215 / 0.0017014302658606788 / 0.0353590157796084 / 0.0012471395414138215 3.174956286948255e-05 / 2.3820952039675057e-05 / 7.64885082423866e-07 / 5.201073420332339e-07 / 3.138162419750589e-05 / 1.8874782131634276e-06 0.011713227 6 138 POU4F1_1 0.0000343460 0.009505749235636515 / 0.01380503352362386 / 0.006032512595643146 / 0.016514991038692903 / 0.03991486389987273 / 0.023304012767638813 1.736820199971154e-08 / 1.0181132930253954e-06 / 0.00018045749659898887 / 7.716585431260322e-06 / 5.0799933930760124e-06 / 2.2950455177001124e-05 0.018179527 6 139 LINGO1_4 0.0000000000 1.7973910992848286e-09 / 3.2068838263254377e-07 / 5.436354594228244e-06 / 9.44534744977059e-08 / 8.340191540542289e-07 4.250081788501893e-07 / 3.2784019242777824e-06 / 9.246191514674586e-06 / 6.77126904336827e-07 / 1.2203319241697544e-05 1.33746E-06 5 140 EZH2_2 0.0000000004 2.2402150648537843e-08 / 1.471749614726362e-06 / 3.983245164121986e-08 / 8.584401402568793e-06 / 2.135362618124217e-07 7.330469554133431e-08 / 6.45181252176691e-06 / 2.8233957548442e-07 / 1.386977654368529e-06 / 3.4840585402585815e-07 2.06638E-06 5 141 ZNF786_5 0.0000000000 0.00011773904137664178 / 1.3280032513820524e-05 / 9.576463103103271e-05 / 4.4014899917305675e-06 / 8.430577899747024e-06 2.140329000239017e-05 / 7.930355204992489e-07 / 4.145669385412816e-06 / 9.512787508368679e-07 / 2.434604498224823e-06 4.79232E-05 5 142 SLCO5A1_1 0.0000008012 3.2501044823812903e-07 / 9.224071980226081e-07 / 0.0003167991900078877 / 2.408755304649635e-05 / 9.289397717877934e-06 3.0174324318950897e-07 / 9.418668072896726e-07 / 1.6676348515768935e-05 / 3.957834622626353e-06 / 6.700293161768197e-06 7.02847E-05 5 143 DKK2_1 0.0000006927 9.224071980226081e-07 / 2.7109747094287326e-07 / 3.2501044823812903e-07 / 0.0004073113752386311 / 9.289397717877934e-06 6.460209020485614e-08 / 3.59230415078595e-07 / 1.0312698979503442e-06 / 1.4199406561075603e-05 / 5.457198354391937e-06 8.36239E-05 5 144 ATP11C_1 0.0000001503 2.7109747094287326e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 0.0004422271229621968 / 5.2109649171464235e-06 1.9332727891019487e-07 / 1.36409072963545e-08 / 3.1896874375468994e-07 / 4.81561728868056e-06 / 8.990145137526255e-07 9.11223E-05 5 145 KMO_1 0.0000001461 1.887107728600381e-05 / 0.0001432193232982916 / 0.0005437871552770366 / 0.00021988598115354305 / 0.0002441254991542676 2.485807963409032e-07 / 1.1240339046572947e-06 / 3.782902556894412e-07 / 4.67845142282578e-06 / 3.603323688705048e-06 0.000233978 5 146 SPOCD1_1 0.0000000083 3.2501044823812903e-07 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 0.0019333915490623197 / 1.615375160694009e-05 7.818277659920641e-08 / 5.795083345677293e-07 / 4.4221671271015996e-06 / 9.908657729834685e-06 / 1.2284458405143113e-05 0.000394173 5 147 LMO3_1 0.0000005163 2.0071481202007584e-05 / 9.224071980226081e-07 / 0.00029640089162746337 / 6.979794879972793e-06 / 0.005510243055764825 2.8303059659858582e-08 / 1.2770021336022465e-07 / 1.8886612700849868e-06 / 1.5048748666061165e-06 / 9.979708008853078e-07 0.001166924 5 148 SUCLG2_1 0.0000006277 0.0012538224517635887 / 0.00030020193073310375 / 0.001142443802029975 / 0.0015995521116198169 / 0.0025493281320611745 6.010018117118236e-09 / 1.4873864874902438e-08 / 2.812059954690805e-06 / 4.5297727245223865e-07 / 1.0136268892104269e-06 0.00136907 5 149 CDC42EP3_1 0.0000005053 0.00015668136762185704 / 0.0017937623479293012 / 0.00014067446309259184 / 0.0006379488254521119 / 0.0054623966213403945 4.0545605557306084e-07 / 2.0579987707958014e-06 / 6.648866334116203e-06 / 6.110689397168396e-05 / 5.05967411068452e-06 0.001638293 5 150 VIM_2 0.0000150468 0.001194606450859983 / 0.00022458373669886374 / 0.00019944988446973612 / 0.006523673737606515 / 0.0004302878134597533 3.450494605886152e-11 / 2.904281074975244e-11 / 4.5432513762116924e-07 / 4.7610232918156417e-07 / 3.936782111680953e-06 0.00171452 5 151 KIAA1456_5 0.0000000000 3.392135383479947e-09 / 1.6065108187886577e-09 / 9.157017996950809e-07 / 3.6928231492352363e-07 5.371804546576567e-07 / 8.674274096479547e-08 / 5.026970587223131e-06 / 3.9399829491464125e-06 3.22496E-07 4 152 ATP1A1_1 0.0000003288 2.7109747094287326e-07 / 3.2501044823812903e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 4.379090848715678e-06 / 3.77167172557141e-06 / 3.5551496515817035e-06 / 8.53191167142631e-06 2.12458E-06 4 153 EFHD2_3 0.0000000000 2.621657181978166e-09 / 5.054801258373376e-07 / 9.68006271762989e-06 / 1.8365412363165977e-07 8.572257412643892e-07 / 1.794103459804273e-06 / 9.95075608052033e-06 / 1.2610525065949156e-05 2.59295E-06 4 154 NPY1R_1 0.0000000555 3.2501044823812903e-07 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 9.224071980226081e-07 3.314259306506593e-07 / 3.2811589034439775e-06 / 2.0319189662380453e-05 / 4.769447269863606e-06 2.70198E-06 4 155 PTPN13_1 0.0000002820 2.7109747094287326e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 5.2109649171464235e-06 2.6783272230077516e-07 / 1.895295482848707e-08 / 1.8806480924583324e-07 / 9.335221622816497e-07 3.34607E-06 4 156 SOX11_3 0.0000000001 1.2099644991608733e-05 / 2.0089868169610723e-07 / 1.0776466574906309e-07 / 4.755876859816789e-06 7.955105981028123e-06 / 1.0121247355306893e-06 / 3.4448329577362182e-06 / 1.4342875182087443e-05 4.29105E-06 4 157 RAVER2_1 0.0000000192 3.2501044823812903e-07 / 9.289397717877934e-06 / 9.224071980226081e-07 / 1.3062838211579366e-05 3.105760909035132e-07 / 7.687495446941115e-07 / 1.1986592733451634e-06 / 9.900405822480467e-06 5.89991E-06 4 158 CD44_3 0.0000000000 7.172707428277077e-07 / 4.481007438950932e-07 / 8.746535299915613e-07 / 2.5220058311922642e-05 1.7230525778249127e-07 / 2.754399275478179e-07 / 5.399255839823898e-06 / 5.404432984233412e-06 6.81502E-06 4 159 WIPI1_1 0.0000000779 3.2501044823812903e-07 / 4.559947241482223e-05 / 9.224071980226081e-07 / 2.408755304649635e-05 2.847754855927293e-07 / 5.356440974504928e-05 / 3.583982029691469e-06 / 9.40961708804259e-06 1.77336E-05 4 160 MEIG1_1 0.0000021159 2.768256422538597e-05 / 9.531965824595176e-05 / 3.738602753166595e-05 / 7.050646137918624e-07 3.8552589093989376e-07 / 5.403268031058945e-06 / 1.875181574291302e-06 / 3.691562617026471e-06 4.02733E-05 4 161 ITGAV_1 0.0000043137 5.198191671140737e-06 / 2.078130544858706e-05 / 8.173042888768766e-05 / 6.124458953230731e-05 2.675335342140057e-08 / 5.91155167762294e-06 / 3.175137319143903e-07 / 1.4088412652065131e-05 4.22386E-05 4 162 WASF1_2 0.0000000139 1.249810740543092e-06 / 4.033558519530211e-05 / 1.5172365718941338e-06 / 0.00016701924649532873 4.465170531049283e-08 / 7.347798043454918e-07 / 3.12571392342915e-07 / 2.1882250573351623e-06 5.25305E-05 4 163 SEPT5_1 0.0000000779 3.2501044823812903e-07 / 9.224071980226081e-07 / 0.0003167991900078877 / 2.0071481202007584e-05 4.6698972944525575e-06 / 2.50941550434497e-06 / 7.4466622077249586e-06 / 4.094296941956349e-06 8.45295E-05 4 164 ZNF703_4 0.0000000000 2.212311553111884e-06 / 7.684875066256022e-06 / 1.6293260278199978e-05 / 0.0008381727818825804 3.314259306506593e-07 / 7.977471601458215e-07 / 1.8053474935255696e-05 / 2.523320003794371e-06 0.000216091 4 165 RCAN1_1 0.0000004561 2.051237402337122e-05 / 0.0008581803853921776 / 1.1263759452799203e-06 / 0.00014547367344876742 1.151531177459646e-07 / 1.639867245393111e-05 / 1.1127380583214237e-07 / 3.9475777725155106e-07 0.000256323 4 166 MEIS1_1 0.0000004303 0.0001249119186090808 / 0.001757554115983901 / 2.051237402337122e-05 / 0.000326206047495105 2.6783272230077516e-07 / 3.936737849973941e-06 / 1.6694305968259358e-06 / 7.365498385123174e-06 0.000557296 4 167 DOCK9_2 0.0000000000 4.145085061135413e-05 / 3.702123384814164e-05 / 0.0003340879256796464 / 0.001986982649747413 2.7146173079304695e-06 / 2.6989667147770683e-07 / 5.081672826189643e-05 / 3.9279153945945585e-05 0.000599886 4 168 MAP2K1_1 0.0000000599 0.0007934067413946306 / 0.001424661642376461 / 0.0001432193232982916 / 0.0001432193232982916 6.397852510979244e-07 / 1.229050427171932e-05 / 4.600454084913176e-07 / 1.216134119529828e-07 0.000626127 4 169 BAZ2A_1 0.0000087909 0.0006400860846326889 / 0.00019507867134893112 / 0.0005646566395776797 / 0.0011256461353458978 3.4543484518327023e-07 / 2.666805309562172e-06 / 5.506146432831658e-07 / 2.9358775945182435e-06 0.000631367 4 170 TMEM70_2 0.0000000042 0.000803532445292482 / 3.592934798967807e-05 / 2.0485173730412846e-05 / 0.002205124341612829 2.2344846667733606e-07 / 1.07351128025269e-06 / 3.1896874375468994e-07 / 3.0408081748624807e-06 0.000766268 4 171 CSRP3_1 0.0000008027 0.0018449614599039168 / 0.00038686777181974065 / 0.00048368218865146016 / 0.001675382961010776 2.60376611739122e-06 / 2.102391157291273e-06 / 2.004512392075139e-06 / 1.2729780600591483e-06 0.001097724 4 172 MSRB3_1 0.0000003307 2.1638869199653735e-05 / 0.0029815335281472605 / 0.0005737747064104953 / 0.007382285536659921 1.4806435472894142e-06 / 1.0110256424760308e-06 / 3.5361568488813283e-06 / 8.63235449098127e-05 0.002739808 4 173 PTGER2_1 0.0000002152 0.00269524080408226 / 0.007101048391336863 / 0.00668150271306391 / 7.915379277260866e-05 3.584070271555361e-09 / 1.3436997812686243e-07 / 1.3606501871455058e-06 / 1.1858761514818132e-06 0.004139236 4 174 ARHGAP44_2 0.0000005305 0.001389487072786441 / 3.911112061086556e-05 / 0.0072669444150837495 / 0.032560551569980084 1.5851926645157727e-06 / 5.333355940483967e-07 / 4.1196587397566423e-07 / 1.9907111943687763e-05 0.010314024 4 175 TTC7A_2 0.0000431038 0.0034136112166290996 / 0.019663495986739683 / 0.015108389305698126 / 0.023304012767638813 1.9331908145550604e-07 / 2.9725508005745186e-07 / 6.456589638188038e-07 / 1.1620049901469098e-06 0.015372377 4 176 SLC35F1_1 0.0000000393 9.224071980226081e-07 / 3.2501044823812903e-07 / 2.7109747094287326e-07 2.910892954811522e-06 / 2.427468480432927e-06 / 1.497883668566738e-05 5.06172E-07 3 177 KRT25_4 0.0000000910 1.8022657475902624e-06 / 3.876432302949376e-08 / 9.243212121314035e-07 8.698985549478663e-06 / 1.3122203018407308e-05 / 2.3955519604051558e-05 9.21784E-07 3 178 PAX7_1 0.0000004451 3.2501044823812903e-07 / 9.224071980226081e-07 / 5.2109649171464235e-06 2.237597740187554e-06 / 4.6661224912755335e-06 / 6.814494589515358e-05 2.15279E-06 3 179 ENC1_1 0.0000002820 3.2501044823812903e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 1.9120440072426562e-07 / 4.6661224912755335e-06 / 2.0866430814653658e-06 2.7424E-06 3 180 ERO1L_3 0.0000000002 4.539445950022412e-06 / 2.5790650047618876e-07 / 3.931265767356836e-06 8.753743400501336e-05 / 2.307172538255043e-06 / 0.0001811706174672882 2.90954E-06 3 181 KANSL2_2 0.0000000036 5.454092964102538e-06 / 2.0483330180932313e-06 / 1.3610927050562742e-06 1.3993846023737915e-07 / 4.67736331535542e-05 / 3.809175259493249e-06 2.95451E-06 3 182 RPN1_3 0.0000000004 8.225833660011401e-07 / 8.696575941061198e-06 / 2.1691780926743226e-07 2.5845817998249264e-07 / 2.15788202970697e-06 / 7.928931114532352e-06 3.24536E-06 3 183 PTGER3_2 0.0000000653 6.627915836434039e-07 / 2.668064610627935e-06 / 6.6526771052306895e-06 4.987581945086968e-07 / 6.416985820926155e-07 / 1.042398266072424e-06 3.32784E-06 3 184 CACHD1_2 0.0000000001 6.841823795764238e-06 / 1.1611327091078624e-06 / 3.757056495538064e-06 6.036905353459894e-07 / 1.7240231306506295e-06 / 2.495170691986825e-05 3.92E-06 3 185 VPS37D_2 0.0000000001 8.999654334938381e-06 / 3.0621601602130305e-06 / 2.72061163246224e-07 5.620700861394285e-07 / 1.1802005266016428e-06 / 1.1362044976111473e-06 4.11129E-06 3 186 ZDHHC17_1 0.0000000110 1.3062838211579366e-05 / 9.289397717877934e-06 / 3.2501044823812903e-07 1.9472709844203468e-07 / 8.64813860440053e-09 / 4.08973006429415e-08 7.55908E-06 3 187 TMEM9B_2 0.0000000138 1.0001419899907697e-05 / 2.088214452889034e-05 / 3.1085970554200676e-07 7.663345318857788e-08 / 9.904773066152364e-07 / 1.645825440209025e-06 1.03981E-05 3 188 HOXD10_1 0.0000000921 2.7109747094287326e-07 / 3.1219185299958266e-05 / 9.224071980226081e-07 2.565463018954012e-06 / 1.941433683772925e-06 / 4.178051372181341e-06 1.08042E-05 3 189 ITFG2_1 0.0000005163 4.559947241482223e-05 / 2.0071481202007584e-05 / 5.2109649171464235e-06 3.439076468267492e-06 / 5.9260015900657735e-06 / 5.4469810926531135e-05 2.36273E-05 3 190 EGFL7_1 0.0000000299 1.1263759452799203e-06 / 4.369070707050029e-05 / 0.00018252021476464813 1.8700341255096223e-09 / 5.293074654152259e-06 / 1.2852959762944565e-05 7.57791E-05 3 191 PPP2R2A_5 0.0000000000 2.3018920608566846e-05 / 2.515879541149387e-06 / 0.00026563530537353084 2.892554421707878e-06 / 2.79139624836141e-06 / 0.0002549462415116326 9.70567E-05 3 192 BRF2_2 0.0000000001 9.751314166241359e-06 / 0.0003129016625892748 / 0.00016417889880625215 3.759229641754634e-08 / 2.1837529883578724e-05 / 1.5455954512499827e-06 0.000162277 3 193 ATP1B2_1 0.0000007792 8.350565572888588e-05 / 0.0003022930393277112 / 0.00012034822430170891 4.9185008634943495e-06 / 1.749159859965176e-05 / 1.758385056892761e-05 0.000168716 3 194 PTGES3_2 0.0000000002 0.00028889915694293186 / 0.0004343373075467472 / 2.3874708929429098e-06 6.3806928808699615e-06 / 3.6976674058849736e-07 / 2.590931905512812e-06 0.000241875 3 195 NR0B1_2 0.0000000017 0.00095500393558891 / 4.835640776889601e-06 / 1.3401582342156554e-08 0.00012317884029827643 / 9.41313565329906e-05 / 1.946170412794958e-05 0.000319951 3 196 GALNT10_2 0.0000073319 0.001194606450859983 / 0.00022458373669886374 / 0.00019944988446973612 4.2967502063254294e-08 / 2.7580106394921852e-08 / 1.6050811528160658e-07 0.000539547 3 197 TMEM229A_1 0.0000019763 1.1263759452799203e-06 / 0.0017875715263402634 / 2.051237402337122e-05 4.470056894883235e-08 / 3.212400793996756e-05 / 3.0330851096686316e-06 0.00060307 3 198 NCEH1_1 0.0000021880 0.0025176594807100345 / 2.9249667673039124e-05 / 0.00049387566368266 2.9852999237846436e-07 / 3.6664065520662378e-06 / 1.4296784245243089e-06 0.001013595 3 199 C1orf27_1 0.0000005347 2.4400796134349794e-05 / 0.00048683461556788134 / 0.004468346085026116 3.3728825978612466e-08 / 1.7773181504273556e-05 / 1.1552987857913018e-05 0.00165986 3 200 TMEM14C_1 0.0000014171 0.00013494197652300576 / 0.008044269920970437 / 0.00043124882395994033 1.4472691259712559e-07 / 6.268977803019969e-07 / 2.4350896869975287e-07 0.002870154 3 201 DKK3_1 0.0000003462 0.0013248126277991738 / 0.0010602701525608943 / 0.008185982685681903 1.5846200021034092e-07 / 9.094647997910571e-07 / 1.069596462403796e-05 0.003523688 3 202 LRRC4C_1 0.0000000007 0.001612584660708291 / 0.008357898545557461 / 0.004641723683002966 5.839066787020226e-06 / 8.030484942525321e-05 / 2.874321825060119e-06 0.004870736 3 203 HOXD9_1 0.0000001816 0.003521766194763358 / 0.009358203838825317 / 0.006565901152596447 8.908782275302052e-08 / 1.4262192253107675e-06 / 1.1653976873204907e-05 0.006481957 3 204 SLC5A6_2 0.0000083594 0.00329856915210616 / 0.016629670900162985 / 0.003718378687262143 3.9237422990064166e-08 / 2.1675313933802943e-06 / 3.4461744463603383e-07 0.007882206 3 205 LYPD1_1 0.0039884477 0.00561851618326168 / 0.010298037138015295 / 0.011465748499709204 0.00012364715000227235 / 7.610927192464296e-06 / 3.436634759679429e-05 0.009127434 3 206 CIB1_1 0.0000012582 2.4400796134349794e-05 / 0.025949952318682364 / 0.005327800743076973 6.521419935683383e-08 / 0.0001508899394071643 / 2.7037258898085093e-06 0.010434051 3 207 PDSS1_2 0.0000001438 2.087686423298029e-05 / 0.032547979119801014 / 0.0009731125399429332 9.181067152023525e-08 / 1.866363701474153e-07 / 7.882821468850854e-06 0.011180656 3 208 SHC2_1 0.0000043527 0.008666672397448167 / 0.01221055371440681 / 0.023108053632132773 3.5046868808471237e-08 / 1.4152639674778885e-07 / 1.1044438525648634e-06 0.01466176 3 209 ATP6V0B_1 0.0000652113 0.0017008783545293586 / 0.03338582426278086 / 0.022359654779542756 1.8156513888722432e-05 / 0.0006738450240411453 / 0.00015710780312305387 0.019148786 3 210 SEPSECS_1 0.0000880523 0.03187722870624648 / 0.03280798665424235 / 0.039867021959100635 2.337882197149697e-08 / 1.6555950610598878e-06 / 2.8381722284939996e-06 0.034850746 3 211 BHLHE22_2 0.0000000002 1.3401582342156554e-08 / 4.659755401849588e-08 1.3361783713514048e-06 / 9.916119753409963e-07 2.99996E-08 2 212 FOXC1_1 0.0000001081 3.2501044823812903e-07 / 9.224071980226081e-07 2.464261525645891e-06 / 8.614020001816719e-06 6.23709E-07 2 213 DMRTA1_1 0.0000001005 1.0687433356337492e-05 / 7.348784993241683e-08 1.8860719855838867e-06 / 7.505602457021459e-06 5.38046E-06 2 214 CRYBG3_2 0.0000000000 7.842763361037193e-06 / 6.517914638754384e-06 1.266977339256832e-07 / 1.1569843022665961e-05 7.18034E-06 2 215 ANKRD28_1 0.0000001762 3.2501044823812903e-07 / 2.0071481202007584e-05 2.0833362771380855e-07 / 1.1004838243302006e-06 1.01982E-05 2 216 ZNF467_3 0.0000000000 1.6294904067329883e-05 / 1.3870388730546243e-05 7.288715501245973e-07 / 2.038126089530678e-07 1.50826E-05 2 217 MCU_1 0.0000000041 4.559947241482223e-05 / 2.7109747094287326e-07 0.00014805201662727028 / 1.3235442660276658e-05 2.29353E-05 2 218 ALG6_1 0.0000000034 4.559947241482223e-05 / 9.289397717877934e-06 7.757632613398362e-05 / 1.8142742683524817e-06 2.74444E-05 2 219 DST_1 0.0000000354 1.1263759452799203e-06 / 0.00018252021476464813 2.5055687616812065e-08 / 7.501693754343125e-06 9.18233E-05 2 220 CNOT6_1 0.0000000101 1.1263759452799203e-06 / 0.0002944288613709527 1.1075622702926509e-08 / 1.129572691211572e-06 0.000147778 2 221 SLC25A46_1 0.0000002913 0.00036105139567184824 / 0.00014547367344876742 2.5994147109530116e-05 / 4.968741535651153e-06 0.000253263 2 222 STRBP_3 0.0000000000 1.5669300524965997e-07 / 0.0005064725174938412 1.481967113051988e-07 / 1.3155160149040273e-05 0.000253315 2 223 SLFN11_1 0.0000000685 2.4400796134349794e-05 / 0.00048683461556788134 1.0022702721591722e-05 / 9.972925901562962e-06 0.000255618 2 224 IL1R1_1 0.0000016239 0.000617308483698201 / 6.569591094283755e-05 4.5432680388905903e-07 / 9.107588752182431e-08 0.000341502 2 225 PDE9A_2 0.0000000400 0.00041731220668757806 / 0.0005855390414154741 1.221895236718122e-05 / 4.308375284196633e-07 0.000501426 2 226 TXNDC11_1 0.0000008009 0.00037816990481376106 / 0.001675382961010776 3.35563055514752e-05 / 1.6158804956085833e-05 0.001026776 2 227 NRP1_2 0.0000038002 0.0004994794183737504 / 0.002324394606725177 5.465744973286784e-06 / 7.656204640097829e-05 0.001411937 2 228 QSER1_1 0.0000182809 0.0013570458512569155 / 0.002178697316418811 9.58284147411479e-06 / 8.84455021841255e-06 0.001767872 2 229 TNIP1_1 0.0000036678 5.198191671140737e-06 / 0.004144214246475889 6.508715673074529e-09 / 0.00019241774459470402 0.002074706 2 230 LIMS1_1 0.0000029556 0.0018263671837831345 / 0.0029439691339069544 1.6606027203704394e-06 / 2.8416546588022426e-06 0.002385168 2 231 PNISR_1 0.0000015994 0.0010325370165401593 / 0.00423890420622936 1.0714836567004093e-06 / 4.211924899648025e-05 0.002635721 2 232 MOAP1_1 0.0001095279 0.0013957283134908426 / 0.004002216537936575 1.439059920097413e-05 / 4.3262437480883325e-07 0.002698972 2 233 KAT2B_3 0.0000000754 0.00036235601618888415 / 0.0056682839670987315 7.275549292242543e-06 / 6.222503271842437e-05 0.00301532 2 234 NBAS_2 0.0001936498 0.002248148734104571 / 0.003937219671693211 5.238094547402913e-05 / 2.261642163972036e-05 0.003092684 2 235 RPAP3_1 0.0000000959 0.006578021053153416 / 0.0003022930393277112 0.00010709405231539574 / 5.7996012896130105e-05 0.003440157 2 236 PCDH8_1 0.0000003649 0.001612584660708291 / 0.0053998526759721725 6.979705922681422e-07 / 2.352485760414308e-06 0.003506219 2 237 NRTN_1 0.0000000085 0.006576322331343084 / 0.000682440200485821 1.3872766655850854e-09 / 1.1570279948530293e-08 0.003629381 2 238 NFE2L3_3 0.0000025415 0.006071092121717285 / 0.001441190253067779 0.0007954168620537718 / 2.313845386160375e-05 0.003756141 2 239 AXL_2 0.0000082526 0.004702764394990607 / 0.0030062439789624545 1.694397819105341e-07 / 2.938209735715061e-06 0.003854504 2 240 FAM84B_1 0.0000011219 0.00253490211532945 / 0.006638130601347837 9.817330455454356e-07 / 1.8299892086956357e-05 0.004586516 2 241 SERPING1_2 0.0000000003 0.00029302171972017536 / 0.00899955161467775 5.171117305573901e-07 / 3.4719444187468846e-06 0.004646287 2 242 MAN2A2_1 0.0000016596 0.008666656930380014 / 0.0017164152096634118 3.010976905505238e-07 / 1.2681089550233342e-06 0.005191536 2 243 PPP1R1B_2 0.0000081910 0.0007369895164838126 / 0.015544944078315552 4.952255809431967e-06 / 0.0008507571424411441 0.008140967 2 244 LIM2_1 0.0000574583 0.015037462614525989 / 0.0066321488107590094 1.3552898512014677e-07 / 1.5995954452124522e-06 0.010834806 2 245 ENC1_1 0.0000008380 0.019200633106000394 / 0.0072430591690685955 9.369739248583604e-07 / 9.796657658766679e-08 0.013221846 2 246 TXNDC15_1 0.0002035799 0.01560397243862297 / 0.026007387241751754 1.3487999148831977e-05 / 2.383861518054849e-06 0.02080568 2 247 CTGF_1 0.0006621219 0.04284073842146925 / 0.004328209862304807 1.2802249170334234e-06 / 4.161322882701981e-06 0.023584474 2 248 EGFLAM_2 0.0000009904 9.101668425963222e-05 / 0.04959722009227676 2.2688565832705132e-07 / 4.996639973079422e-06 0.024844118 2 249 ARHGAP10_2 0.0000000002 1.0829140297466289e-09 3.358932763107935e-10 1.08291E-09 One 250 EBF3_1 0.0000002820 2.7109747094287326e-07 1.8343370720153953e-05 2.71097E-07 One 251 PLAGL2_1 0.0000000508 3.2501044823812903e-07 1.8455903922148852e-07 3.2501E-07 One 252 XKR4_3 0.0000000000 3.984768315573071e-07 3.1239365009333255e-05 3.98477E-07 One 253 HR_1 0.0000000121 9.224071980226081e-07 1.9179741330821166e-06 9.22407E-07 One 254 GLB1L2_1 0.0000000160 1.1263759452799203e-06 7.033045636092652e-08 1.12638E-06 One 255 GOLIM4_1 0.0000004900 1.1263759452799203e-06 6.007938707379104e-06 1.12638E-06 One 256 TMEM127_1 0.0000000593 1.1263759452799203e-06 4.773025688625418e-08 1.12638E-06 One 257 USP21_1 0.0000003387 1.1263759452799203e-06 9.225028218311642e-07 1.12638E-06 One 258 FAIM_5 0.0000000000 1.1673685534992903e-06 9.826697889420593e-07 1.16737E-06 One 259 COX19_2 0.0000000297 2.674810306988624e-06 6.962982384295879e-06 2.67481E-06 One 260 LRP10_3 0.0000000000 4.146152323500948e-06 2.8381722284939996e-06 4.14615E-06 One 261 ASPH_1 0.0000031107 5.198191671140737e-06 1.24607424448712e-09 5.19819E-06 One 262 CASP4_1 0.0000231527 5.198191671140737e-06 8.920036916236078e-07 5.19819E-06 One 263 PPFIBP1_1 0.0000009218 5.198191671140737e-06 2.822471900981502e-07 5.19819E-06 One 264 PRRX2_1 0.0000102422 5.198191671140737e-06 1.997454040091158e-06 5.19819E-06 One 265 TADA1_1 0.0000011043 5.198191671140737e-06 4.130298014547339e-06 5.19819E-06 One 266 FBXO15_2 0.0000000001 7.752739683840974e-06 1.0459642383728147e-08 7.75274E-06 One 267 RPRD1A_3 0.0000000001 1.0121621258597313e-05 5.117366799673119e-08 1.01216E-05 One 268 HS3ST3B1_2 0.0000000001 1.589621421980893e-05 5.712322089852472e-05 1.58962E-05 One 269 RBM39_1 0.0000000427 1.615375160694009e-05 1.0486585374452342e-06 1.61538E-05 One 270 MRPS34_1 0.0000059445 2.078130544858706e-05 3.007629978522511e-07 2.07813E-05 One 271 PPARD_1 0.0000000391 2.4400796134349794e-05 1.781378071484659e-07 2.44008E-05 One 272 TRIM29_2 0.0000000342 2.5328503789616034e-05 3.171256366090173e-06 2.53285E-05 One 273 SLITRK3_2 0.0000000001 2.606975599460185e-05 1.5642166542934073e-05 2.60698E-05 One 274 AOX1_1 0.0000000161 2.9249667673039124e-05 1.5889876142270276e-06 2.92497E-05 One 275 WDR41_1 0.0000008795 3.490933492066787e-05 0.00031815123884038185 3.49093E-05 One 276 WDR60_1 0.0000000100 3.54688199707126e-05 5.069649573469536e-05 3.54688E-05 One 277 ELOVL1_1 0.0000000046 3.613318380627543e-05 2.329132806551381e-05 3.61332E-05 One 278 ISYNA1_1 0.0000000671 4.335544688590604e-05 1.6739811178590666e-07 4.33554E-05 One 279 BTBD17_1 0.0000001085 4.559947241482223e-05 5.155148635414614e-07 4.55995E-05 One 280 E2F6_1 0.0000000779 4.559947241482223e-05 1.7462091622562324e-05 4.55995E-05 One 281 REEP5_1 0.0000012251 4.559947241482223e-05 4.0559240566408105e-05 4.55995E-05 One 282 HIF3A_2 0.0000001724 5.1802263378395004e-05 7.343981030754773e-06 5.18023E-05 One 283 PLIN3_1 0.0000007202 7.498301012054149e-05 8.715915351978061e-08 7.4983E-05 One 284 SLC25A43_1 0.0000000584 7.498301012054149e-05 1.042304728724042e-06 7.4983E-05 One 285 NINL_2 0.0000000000 8.157777488089495e-05 1.9047854067387114e-06 8.15778E-05 One 286 ZNF232_2 0.0000000005 9.615096996117447e-05 2.7228077881606553e-05 9.6151E-05 One 287 SIRT4_5 0.0000000006 9.759198409764184e-05 0.00022059348443664346 9.7592E-05 One 288 TP53BP2_1 0.0000015006 0.00011602560329098725 1.0705081193459222e-06 0.000116026 One 289 DLGAP1_1 0.0000000768 0.0001432193232982916 3.5620325640614317e-07 0.000143219 One 290 ELL2_1 0.0000001831 0.00014547367344876742 1.8060650315234512e-06 0.000145474 One 291 L3MBTL1_1 0.0000000672 0.00015165886425239433 2.7256307870565235e-06 0.000151659 One 292 VCL_1 0.0000000164 0.00015165886425239433 3.3683533578357084e-06 0.000151659 One 293 FOXN4_1 0.0000000718 0.00018648294090879803 6.71170895523933e-08 0.000186483 One 294 DGKD_2 0.0000000001 0.00021891772305978252 3.0596605696933097e-07 0.000218918 One 295 UHMK1_2 0.0000022832 0.0002538027145357861 1.287838376941801e-06 0.000253803 One 296 ATG10_1 0.0000013709 0.00045105792374135455 1.9817995812370057e-05 0.000451058 One 297 RTN4_1 0.0000004000 0.0005279514394131604 2.4302265052169763e-06 0.000527951 One 298 ZBTB34_2 0.0000000006 0.000905796995991497 2.480782410785219e-06 0.000905797 One 299 TRAPPC1_1 0.0000002410 0.0009321635980700065 5.038494138176741e-08 0.000932164 One 300 MAN1A1_1 0.0000012120 0.0010091155669931342 9.89628655829039e-07 0.001009116 One 301 GPR155_1 0.0000001571 0.0010353911778693099 2.456527177029259e-08 0.001035391 One 302 NUP205_1 0.0000011129 0.0012133361599562802 4.618395361515403e-05 0.001213336 One 303 DFNA5_1 0.0000000842 0.0013248126277991738 1.0306269703522314e-06 0.001324813 One 304 ESYT2_1 0.0000000362 0.0014584828902455792 1.480537378886556e-06 0.001458483 One 305 ARRDC5_1 0.0000004478 0.0016631235717637551 5.470825563951457e-06 0.001663124 One 306 WWOX_1 0.0000000652 0.001710012299865077 3.466057717888151e-05 0.001710012 One 307 TTC12_1 0.0000000828 0.001757554115983901 1.1207466412214644e-06 0.001757554 One 308 PHLDA1_1 0.0000002242 0.0025176594807100345 2.681228774385004e-07 0.002517659 One 309 USP44_2 0.0000000006 0.002828735395322951 7.615307891070635e-07 0.002828735 One 310 PLTP_1 0.0000001423 0.0037115156714849027 6.256739082396771e-06 0.003711516 One 311 FOXK2_2 0.0017280500 0.004268133535531114 1.124004668909467e-06 0.004268134 One 312 ERRFI1_1 0.0000343124 0.004549100059734061 2.615853467480574e-06 0.0045491 One 313 NCAPG2_2 0.0000096301 0.004679455399141524 3.410090272140929e-05 0.004679455 One 314 GNG12_2 0.0000008966 0.004702764394990607 2.448152787066068e-07 0.004702764 One 315 GTF2IRD1_2 0.0000000000 0.005180332874805364 1.0191189286267774e-05 0.005180333 One 316 CDH13_1 0.0000528396 0.008698504315979544 5.505206380486848e-07 0.008698504 One 317 USPL1_1 0.0000887089 0.008919618004927028 2.867060371186775e-05 0.008919618 One 318 C8orf33_2 0.0000000686 0.012040847937930112 6.965053271201718e-06 0.012040848 One 319 LARP4_1 0.0000539238 0.012598829000918008 1.5446384568414948e-07 0.012598829 One 320 WISP2_3 0.0007560493 0.015549504727258205 4.1338081640385414e-05 0.015549505 One 321 ACTR3B_1 0.0000005421 0.01578579910468178 2.8755424998338056e-06 0.015785799 One 322 CACNA1H_1 0.0000005564 0.016412811603890378 2.7000252287495107e-06 0.016412812 One 323 KIT_5 0.0000464952 0.018517123226998455 6.704030752101419e-08 0.018517123 One 324 PFKFB4_1 0.0000652997 0.020508581406833964 3.9540280994682333e-05 0.020508581 One 325 PRKCA_1 0.0000002757 0.022453642395359744 8.550515929117645e-06 0.022453642 One 326 PPIB_1 0.0005395298 0.022633220383071653 1.1620529438552381e-07 0.02263322 One 327 GUK1_1 0.0002165806 0.025889538503308045 0.00027733726642677973 0.025889539 One 328 TOMM20_1 0.0000295101 0.026424697119045135 5.7696335620157635e-06 0.026424697 One 329 MCFD2_1 0.0000296801 0.02889039127169977 5.21788791253075e-06 0.028890391 One 330 ARL2BP_1 0.0009748737 0.03656942798482464 2.769366837708274e-07 0.036569428 One 331 DSTN_2 0.0000209668 0.040590852862758056 0.0002808473162478281 0.040590853 One

Next, the biomarker that affects the reactivity to drugs for each drug type, calculated through GBLscan using the functional subflow type in the present invention, will be described.

Specifically, by type of drug type (Drug Class), 108 biomarkers of ABL (see Table 15), 132 biomarkers of CHROMATIN (see Table 16), 832 biomarkers of EGFR (see Table 17), ERK_MAPK There are 42 biomarkers (see Table 18), 153 biomarkers of IGFR (see Table 19), and 88 biomarkers of MITOSIS (see Table 20).

[Table 15] to [Table 20] below include biomarkers discovered by the present invention for each drug type. Here, the form and expression method of the biomarker are the same as the biomarker classified for each cancer type.

Definition of drug type (DrugClass) targeting specific pathway & signaling division DrugClass Drugs Pathway & signaling (Target gene & function) One ABL Imatinib, GNF-2, Dasatinib, Saracatinib, WH-4-023, Bosutinib, Ponatinib, HG-5-113-01, Nilotinib ABL, SRC, KIT, PDGFR, ABL1, TEC, LOK, LTK, TRCB, 2 CHROMATIN Phenformin, AICA_Ribonucleotide, Daporinad HDAC, RAR, HDAC inhibitor Class I, IIa, IIb, IV; HDAC6, EGFR, G9a (EHMT2), GLP (EHMT1), Q8TEK3 (DOT1L), BRD2, BRD3, BRD4 3 EGFR Gefitinib, Erlotinib, Cetuiximab, Lapatinib, Afatinib, HG-5-88-01, CP724714, Pelitinib ERBB2, EGFR, ADCK4 4 ERK_MAPK Dabrafenib, VX-11e, AZ628, Selumetinib, CI-1040, PD0325901, Selumetinib, Refametinib, Trametinib, TL-2-105, HG6-64-1, PLX-4720, SB590885, SL0101, CMK, FMK, FR = 180204 MAP2K1 (MEK1), MAP2K2 (MEK2), BRAF, ERK, RSK, AURKB, PIM3, CRAF, BRAFV600E, TAK, MAP4K5 5 IGFR CSK1904529A, BMS-536924, BMS-754807, Linsitinib IGF1R 6 MITOSIS Dacinostat, JQ1, SGC0946, VNLG / 124, UNC0638, Belinostat, CUDC-101, Vorinostat, CAY10603, AR-42, I-BET-762, Tubastatin A, PFI-1, Entinostat, JQ12 AURKB, MPS1, KIF11, AURKA, PLK3, AURKC, FLT3, ABL1, JAK2, PLK3

Table 15 shows the biomarkers associated with ABL drugs and the degree of reactivity (P-value) of the drugs.

In Table 15, FRH was expressed in the form of "FRH name_number of markers included", and "Var_Drug (pval)" refers to the value of the correlation (P-vlaue) of the marker on drug reactivity. According to the order of reactivity, the correlation value for each drug is divided into the division factor 『/』, and 『Var_Exp (pval)』 means the correlation (Pvlaue) value that each marker has on the corresponding gene expression. , Also, according to the order of the markers, the values of the reactivity correlation for each drug are classified as the classification factor 『/』.

From these reactivity verification results, it can be determined that the lower the Var_Drug (pval) and Var_Exp (pval), the higher the effectiveness of the corresponding marker as a biomarker for determining drug reactivity.

Meanwhile, in FIG. 37, correlation values (P-vlaue) values of the major biomarkers among the biomarkers described in [Table 15] for ABL drugs are graphically displayed.

Reactive biomarker for ABL drug and verification result of reactivity with drug No. FRH Variants Var_Drug (pval) Var_Exp (Pval) One MEI1_1 22_41743050_G_A 4.85E-06 0.048265101 2 MYO1E_1 15_59223315_G_A 9.45E-06 0.007356789 3 HSPG2_1 1_21855190_T_G 3.11E-05 0.047030976 4 DUS1L_1 17_82060026_C_T 3.91E-05 0.03583129 5 ANXA2_1 15_60382524_A_G 5.75E-05 0.01380595 6 CDA_1 1_20613970_T_C 0.000123749 0.01233326 7 R3HDM1_1 2_135621624_GT_G 0.000150326 0.007933574 8 HMGB1_1 13_30465849_T_C 0.000160907 1.54E-07 9 TRIM35_1 8_27311444_G_A 0.000300142 0.010188344 10 NMT2_1 10_15119275_A_C 0.000338877 0.015194231 11 WWC1_1 5_168453939_T_G 0.000400908 0.007809824 12 EPB41_1 1_28987461_G_A 0.000407874 0.032052572 13 TGS1_1 8_55790504_CT_C 0.000507403 0.000527822 14 CLIP4_1 2_29189528_C_T 0.000680402 0.012550596 15 PPFIBP1_1 12_27671307_G_A 0.000932648 0.043451196 16 GNG12_1 1_67707581_C_T 0.000988807 0.022170841 17 MATN3_1 2_20002159_T_TACAC 0.000997596 0.02071966 18 LAMA5_1 20_62325178_T_C 0.001153135 0.010970602 19 SECISBP2_1 9_89319872_A_G 0.001203729 0.020014055 20 CARD10_1 22_37506170_T_C 0.001543214 0.032625328 21 CELF3_1 1_151714507_T_A 0.001901287 0.026406472 22 RPRD2_1 1_150470594_A_C 0.002054115 0.049994398 23 LONP1_1 19_5707040_C_G 0.002145064 0.014919269 24 CELSR1_1 22_46397746_T_G 0.002174791 0.029193759 25 AVPI1_1 10_97677649_A_G 0.002288252 0.001581419 26 HEATR5A_1 14_31321626_G_C 0.002664426 0.037377577 27 ABCC3_1 17_50687493_T_G 0.002687235 0.008875192 28 BCL9L_1 11_118897861_A_C 0.003330363 0.034238861 29 ATP9A_1 20_51712877_T_C 0.003711948 0.007942465 30 PPL_1 16_4899248_T_G 0.003916476 0.036032874 31 WTIP_1 19_34482571_G_A 0.004231715 0.04930162 32 SEC11C_1 18_59152698_T_C 0.004414812 0.00225746 33 RIN2_1 20_19990244_G_A 0.004460992 0.013004393 34 VPS13C_1 15_61910091_C_T 0.004506626 0.031208891 35 WAS_1 X_48691219_A_C 0.004569497 0.02612273 36 ITGA2_1 5_53062931_TA_T 0.005690843 0.016066848 37 SNX6_1 14_34581380_G_T 0.006210652 0.003379828 38 ITGB5_1 3_124769064_T_G 0.006500498 0.000658854 39 KIF13A_1 6_17796543_CTT_C 0.006766834 0.022643788 40 HNRNPD_1 4_82373387_A_G 0.006955259 0.035424294 41 PDE7A_1 8_65724444_TATAA_T 0.006982791 0.049491005 42 TAB1_1 22_39417620_CA_C 0.007324331 0.041922448 43 TSPAN17_1 5_176657159_A_G 0.009147394 0.031164715 44 MYO1C_1 17_1484178_C_T 0.009858187 0.007802374 45 CDC42BPA_1 1_227318293_C_CG 0.010493359 0.000358115 46 ACTN4_1 19_38728028_T_G 0.011156467 0.005408687 47 MET_1 7_116757685_T_G 0.012677621 5.06E-05 48 GPC1_1 2_240451010_T_G 0.013814172 0.00346274 49 HERC1_1 15_63725445_C_A 0.014048274 0.007901005 50 RAB13_1 1_153982198_T_C 0.015384036 0.007436568 51 UBE2N_1 12_93411182_C_T 0.015885474 1.51E-06 52 STRBP_1 9_123266116_C_G 0.017136074 0.001078377 53 EZH1_1 17_42729015_C_CA 0.018478925 0.00312166 54 RNASEH2B_1 13_50956394_G_T 0.01852788 0.005925233 55 LTBP3_1 11_65547976_T_G 0.019306265 0.001002058 56 EGFR_1 7_55205662_A_C 0.020078083 0.000779757 57 LPIN3_1 20_41358465_C_G 0.020089538 6.89E-05 58 PHF21A_1 11_46079428_CT_C 0.020895851 0.00265565 59 SPR_1 2_72891611_A_C 0.021434042 0.000101783 60 RCHY1_1 4_75509142_T_A 0.022232183 7.00E-06 61 EPHA2_1 1_16148437_A_C 0.023495387 0.003022958 62 GMEB1_1 1_28690201_G_T 0.025608914 0.005247117 63 KRI1_1 19_10565667_A_T 0.026306225 2.71E-07 64 MADD_1 11_47325027_T_C 0.027877784 0.001497343 65 ITGAV_1 2_186622542_G_T 0.027935094 0.000708467 66 FN1_1 2_215384980_GA_G 0.028277863 0.006411138 67 ITGB8_1 7_20404676_A_G 0.03058173 0.00229404 68 MYOF_1 10_93341723_C_T 0.031403296 1.02E-05 69 MICALL1_1 22_37911902_T_C 0.031573614 0.005136303 70 TXNL4A_1 18_80033872_T_C 0.035325542 0.000843174 71 AHR_1 7_17339074_A_C 0.036910472 0.009928124 72 HCFC1_1 X_153963207_T_G 0.040430125 0.001579155 73 TJP1_1 15_29761137_A_C 0.040841908 0.005695684 74 DPF1_1 19_38216453_A_C 0.041618699 0.002769532 75 TUFT1_1 1_151565936_G_A 0.042197322 0.004559558 76 CNN3_1 1_94903018_TA_T 0.044343955 0.002044509 77 CALD1_1 7_134891710_CTT_C 0.044361406 0.006749784 78 DCP1A_1 3_53342054_G_C 0.044944752 0.003471409 79 CNBP_1 3_129183756_G_T 0.045255004 0.001660507 80 CDC42BPB_1 14_102952453_T_G 0.046084899 0.003315245 81 ZNF557_2 19_7083618_A_G / 19_7083750_A_G 0.00011707290070365984 / 6.389914683218769e-05 1.6329734686551152e-07 / 4.640996358288638e-07 82 TSC22D1_2 13_44574373_G_T / 13_44436480_G_A 0.00011795878001107085 / 0.0037018440403040202 0.0064804726533923464 / 0.03180017409101453 83 KDM2B_2 12_121579943_C_CA / 12_121444386_T_G 0.0001937979358872413 / 0.00792596940180308 0.01794421156168876 / 0.019501973878425127 84 TMEM206_3 1_212365230_C_T / 1_212377513_G_A / 1_212377773_C_T 0.00020121681284993422 / 0.0003349904631200686 / 5.8829810838971604e-05 0.015527989364148976 / 0.03220676605475732 / 0.012309846725869236 85 CNOT10_2 3_32727933_TAA_T / 3_32704796_GT_G 0.0004336510041481753 / 0.008993061026214434 0.009535253937430231 / 0.00725632017358903 86 AHNAK2_6 14_104939818_T_C / 14_104947943_T_G / 14_104955559_A_C / 14_104949306_T_C / 14_104950989_T_C / 14_104944923_A_G 0.0013733032135289033 / 9.993054536650758e-05 / 0.0009826292819827367 / 0.008303598761450906 / 0.009151781473220755 / 0.016815570915054142 0.0009255099251631373 / 0.014057846162243957 / 0.00506490504122054 / 0.005256944789299486 / 0.039201386575838416 / 0.004782218518041667 87 HNRNPH1_2 5_179614784_GAAAAA_G / 5_179616992_TA_T 0.0015622332101704927 / 0.013101283499781437 0.009729395921872941 / 0.006282233288170697 88 KCTD11_2 17_7355768_G_A / 17_7353417_T_G 0.0021551269324258863 / 0.011987917410278012 0.042125567363077016 / 0.0012683162409826913 89 DCBLD2_2 3_98800637_G_A / 3_98822022_G_A 0.002171037536345973 / 0.000251692831370466 0.02405283820151249 / 0.02321925017861924 90 MICALL2_6 7_1434706_A_T / 7_1436884_C_A / 7_1436960_A_G / 7_1434574_G_A / 7_1438692_G_A / 7_1438940_G_A 0.0035785281207345704 / 0.005806506395454868 / 0.0023336782590812483 / 0.003953693182824404 / 0.01322256820373324 / 0.01322256820373324 0.03116600791585888 / 0.020144032243767682 / 0.0387968938865376 / 0.018579241850634483 / 0.001706040259270731 / 0.001706040259270731 91 YEATS4_3 12_69360050_G_A / 12_69360067_T_C / 12_69359732_G_C 0.004863813186856697 / 0.017375818716536366 / 0.03137776422130159 0.00020734016607029562 / 9.576513142549652e-05 / 0.00015854860163792644 92 FAM129B_2 9_127505498_C_G / 9_127507507_A_G 0.0058285941972244645 / 0.02690463941303876 0.011307547073529664 / 0.009068416405751362 93 DAZAP1_2 19_1432575_T_C / 19_1434836_G_C 0.007270894232908141 / 0.04710249822900437 0.008783799588482919 / 0.0025498805972486143 94 TRIO_2 5_14390880_CT_C / 5_14489165_TA_T 0.008880626014071066 / 0.01650056581622358 7.026077789590974e-05 / 0.0025442006562780626 95 LTBR_2 12_6385217_T_C / 12_6385074_A_G 0.009079148191429435 / 0.006460458599235777 9.805545850814532e-05 / 0.044833733345219534 96 CRIM1_2 2_36479368_G_C / 2_36441370_A_C 0.009119609813496462 / 0.019906184227680684 0.012444715286562538 / 0.003648330338783967 97 LRRC1_2 6_53795560_C_T / 6_53922469_G_C 0.01198676814286411 / 0.0006843529222630762 0.000908035692517222 / 0.04843244804719673 98 PLEC_3 8_143935900_T_G / 8_143916360_A_G / 8_143919099_A_G 0.014640529544546175 / 0.009983558087568838 / 0.034402276881097434 0.0004960012901022363 / 0.00910116635228719 / 0.0010288222361061275 99 CCAR1_4 10_68737725_A_G / 10_68749117_T_C / 10_68786466_C_T / 10_68747145_CT_C 0.01483460962771855 / 0.019812419206917474 / 0.021724978822350548 / 0.012199365670034771 0.007861846127742463 / 0.007748422295395019 / 0.009002153564015953 / 0.007417608363424872 100 PBRM1_10 3_52550415_T_TCTC / 3_52550699_A_G / 3_52576635_T_A / 3_52603470_C_G / 3_52609291_A_G / 3_52658108_G_A / 3_52658343_C_G / 3_52642048_AC_A / 3_52642050_A_T / 3_526412 0.015475400089384512 / 0.0016628718776702444 / 0.035404535122126136 / 0.013312042665148668 / 0.0242839606361519 / 0.02159841119723304 / 0.03729870903666122 / 0.025323429673084204 / 0.025323429673084204 / 0.0001941847064581337 0.0035430700286634563 / 0.0001926448792301472 / 0.007441673662340349 / 0.002758979013645352 / 0.0010612844220239503 / 0.004958532862731571 / 0.004683945580784586 / 0.00010786476378721626 / 0.00010786476378721626 / 0.04797045127180218 101 EPAS1_2 2_46356096_C_A / 2_46375583_T_C 0.01783131944184612 / 0.0010999393665466503 0.008349664569290316 / 0.024779624499683697 102 MYL12B_2 18_3277079_C_A / 18_3261766_G_T 0.02040887855273308 / 0.006963645724708455 0.0006636499143577351 / 0.002628020597022407 103 ASPH_3 8_61578734_T_G / 8_61642872_G_A / 8_61638365_TA_T 0.02703041744922913 / 0.04217140046834995 / 0.0037026849241301204 0.00027481062695969863 / 9.242250914202104e-05 / 0.0033421074285719613 104 CTTN_2 11_70433765_G_C / 11_70433037_T_G 0.028796315723836858 / 0.0215077683383786 0.008528354106314544 / 0.004388396641544275 105 GBP3_2 1_89009135_A_G / 1_89013185_G_A 0.03712796271516626 / 0.046403726190448136 2.531316619591342e-10 / 0.003766535351837685 106 RBM6_3 3_50077082_C_T / 3_50066484_G_A / 3_50075273_C_A 0.03754138190716002 / 0.009406589543431777 / 0.006286329345703225 4.469564601606787e-06 / 0.014325869585835831 / 0.04790544676634136 107 GULP1_2 2_188589974_C_CT / 2_188569425_C_A 0.04155742757047321 / 0.00797269939608827 0.004507263398919969 / 0.006203700518672077 108 RAI14_2 5_34822821_T_C / 5_34795871_A_G 6.659980942617595e-05 / 0.005987810799744655 0.002995737088482826 / 0.006423617908157835

Table 16 shows the biomarkers associated with the CHROMATIN drug and the degree of reactivity (P-value) of the drug by the table.

In [Table 16], FRH was expressed in the form of "FRH name_number of markers included", and "Var_Drug (pval)" refers to the correlation (P-vlaue) value of the marker on drug reactivity. According to the order of reactivity, the correlation value for each drug is divided into the division factor 『/』, and 『Var_Exp (pval)』 means the correlation (Pvlaue) value that each marker has on the corresponding gene expression. , Also, according to the order of the markers, the values of the reactivity correlation for each drug are classified as the classification factor 『/』.

From these reactivity verification results, it can be determined that the lower the Var_Drug (pval) and Var_Exp (pval), the higher the effectiveness of the corresponding marker as a biomarker for determining drug reactivity.

Meanwhile, in FIG. 38, correlation values (P-vlaue) values of CHROMATIN drugs of major biomarkers among the biomarkers described in [Table 16] are graphically displayed.

Reactivity biomarker for CHROMATIN drug and verification result of reactivity with drug No. FRH Variants Var_Drug (pval) Var_Exp (Pval) One SPR_1 2_72891611_A_C 1.13E-09 0.000101783 2 BCL9L_1 11_118897861_A_C 3.13E-08 0.034238861 3 ZDHHC7_1 16_84981848_T_G 1.25E-07 0.007398316 4 CCDC69_1 5_151185396_T_C 2.83E-07 0.005439839 5 DDX60_1 4_168220820_G_T 4.91E-07 0.047715445 6 RASSF5_1 1_206507640_A_C 6.00E-07 0.042432506 7 C21orf58_1 21_46302477_A_G 5.32E-06 0.028316032 8 KIAA0922_1 4_153466445_G_C 1.35E-05 0.014460739 9 NR2F2_1 15_96331144_C_T 1.41E-05 0.041165877 10 WWC2_1 4_183261395_G_T 2.29E-05 0.017749371 11 ERRFI1_1 1_8013331_A_G 3.34E-05 0.000188249 12 KIAA1191_1 5_176361895_T_C 4.29E-05 0.02279099 13 QSOX1_1 1_180196892_T_G 5.61E-05 0.048904626 14 NTN4_1 12_95683554_A_C 5.86E-05 0.007698614 15 KIFC3_1 16_57765532_T_G 6.78E-05 0.038497261 16 LPP_1 3_188484677_T_G 7.25E-05 0.027828249 17 TUFT1_1 1_151565936_G_A 8.20E-05 0.004559558 18 CDC14B_1 9_96496393_T_TACC 0.000102442 0.034844355 19 DTX1_1 12_113093500_A_T 0.000105094 0.02107386 20 P4HA2_1 5_132227207_C_T 0.000133282 0.048816114 21 ARHGAP25_1 2_68818005_T_G 0.000231771 0.004043302 22 TIMM13_1 19_2425296_G_C 0.000236058 0.025389471 23 CAST_1 5_96741643_A_C 0.000249549 0.007284203 24 PTPN12_1 7_77627576_G_C 0.000317226 0.012844299 25 MED28_1 4_17614675_T_G 0.000322999 0.029816577 26 SLC35F5_1 2_113723196_TA_T 0.000333219 0.009792442 27 TPBG_1 6_82364929_T_C 0.000334942 0.003828919 28 CD79B_1 17_63932334_A_C 0.000528438 0.048052988 29 DIRC2_1 3_122856322_A_G 0.000825084 0.013416691 30 UEVLD_1 11_18558312_C_A 0.000960879 0.026771319 31 LRP10_1 14_22875577_A_C 0.001001744 0.013008771 32 UGDH_1 4_39504307_CA_C 0.001468644 0.048378289 33 VMP1_1 17_59841357_A_C 0.001495454 0.00700708 34 DOT1L_1 19_2190948_TTGG_T 0.001590625 0.039142783 35 OSMR_1 5_38933647_C_T 0.001601244 0.048095084 36 CYR61_1 1_85581605_TA_T 0.001618999 0.000620768 37 EMP1_1 12_13211531_T_G 0.001632317 0.001600571 38 PRDM2_1 1_13781628_C_T 0.001853506 0.028812792 39 UBE2N_1 12_93411182_C_T 0.001919604 1.51E-06 40 PDE7A_1 8_65724444_TATAA_T 0.001930609 0.049491005 41 ZNF775_1 7_150397765_G_A 0.002410672 0.02103353 42 ACSS2_1 20_34920910_T_G 0.002415783 0.038456731 43 TNRC6C_1 17_78049826_A_C 0.002419277 0.037719795 44 OPTN_1 10_13108909_T_C 0.002658339 0.009854403 45 FHL2_1 2_105398737_G_C 0.002849654 0.020214714 46 TSR2_1 X_54440646_T_G 0.003023868 0.016676081 47 PON2_1 7_95406313_A_C 0.003172125 9.37E-06 48 RIN2_1 20_19990244_G_A 0.003495398 0.013004393 49 ACVR1_1 2_157780624_GA_G 0.003989606 0.003394881 50 ARRB2_1 17_4720324_T_G 0.004024916 0.04522165 51 STRBP_1 9_123266116_C_G 0.005108062 0.001078377 52 APLP2_1 11_130110790_G_A 0.006767893 0.002129537 53 PPM1D_1 17_60656555_C_G 0.007483948 0.004279928 54 MICALL2_1 7_1442358_T_G 0.008296918 0.00384944 55 SDC4_1 20_45330303_T_G 0.00885313 0.000496261 56 MAP4K1_1 19_38617327_T_G 0.009035501 0.013203631 57 DDX51_1 12_132144264_G_A 0.00950629 0.039746501 58 CD63_1 12_55725568_A_C 0.010191282 0.006277176 59 TSEN34_1 19_54192354_T_G 0.015320711 0.001848481 60 RND3_1 2_150487464_GA_G 0.016355986 0.009852344 61 DYNC1LI2_1 16_66723584_GTTT_G 0.020987801 0.00547115 62 ATG4D_1 19_10547046_A_G 0.025677384 0.001170719 63 TEAD4_1 12_3019250_C_T 0.025841261 0.001625407 64 SPATS2L_1 2_200329386_C_A 0.025958546 0.003348759 65 TCF3_1 19_1627423_T_C 0.04297822 0.006623288 66 GPX8_1 5_55164338_T_C 0.043500083 0.000150103 67 CHD7_1 8_60781091_A_C 0.049386713 0.009144258 68 IQCB1_1 3_121788568_C_T 0.049430015 1.56E-06 69 CD84_2 1_160549875_A_G / 1_160550877_C_G 0.00011388443370850483 / 0.0007812325110491749 0.011914227680681896 / 0.04088607952168802 70 GSN_2 9_121300011_T_G / 9_121321305_A_C 0.00014939533964484881 / 0.03316947281106813 0.027350252864946387 / 0.0036521684936499576 71 PTPRC_2 1_198703381_A_C / 1_198752063_T_C 0.00016494389721910315 / 0.0013479983597789753 0.02703768662070396 / 0.04525193826667434 72 DAG1_2 3_49531399_T_G / 3_49530812_A_G 0.00020026524182288077 / 0.006009115344867996 0.000829773140052924 / 0.031395065099950874 73 CLEC16A_3 16_11156556_C_A / 16_11060913_G_A / 16_11042191_C_G 0.0002094249249848047 / 6.263351817687237e-07 / 0.000591215275919509 0.00562768771681351 / 0.001657798405900209 / 0.0008509758531100063 74 SEMA3C_2 7_80748927_A_C / 7_80758439_T_G 0.00023588106210457256 / 0.002402247845707725 0.04566908222348532 / 0.022537466343331126 75 MYO1E_3 15_59272288_G_C / 15_59223315_G_A / 15_59138181_A_C 0.0002531868313324391 / 0.017294701356675626 / 0.012353995820357604 0.006181875879725325 / 0.0073567891788311425 / 0.000506485287819266 76 FBRSL1_2 12_132582046_C_T / 12_132490757_A_G 0.0002541174963279791 / 0.0016132414574028821 0.017168862085872382 / 0.014332097218830869 77 PLAUR_2 19_43665377_C_A / 19_43665506_A_C 0.0004816822177162012 / 0.000329711238045009 0.013703989625456308 / 0.02821338934893095 78 UPP1_2 7_48108129_C_G / 7_48108147_T_G 0.0005053096271809359 / 0.032569834532674265 0.0002337913556195707 / 0.0015081620173450355 79 TM4SF1_3 3_149375338_T_G / 3_149375342_T_G / 3_149375345_A_G 0.0006450924297222392 / 0.00041880937510606033 / 0.0045963625050391855 0.00025288036755393063 / 0.005766354533635817 / 0.02993773631668 80 ZNF430_4 19_21020746_C_T / 19_21022725_C_T / 19_21034405_A_G / 19_21022773_T_G 0.0006475458714423392 / 0.0074498992574896375 / 0.001227492240630532 / 0.0008007999312255407 0.0014493947676260713 / 7.931044376997757e-06 / 0.043344266998276815 / 0.024171318376603662 81 CYTIP_2 2_157427544_C_T / 2_157427198_A_G 0.000837855207497095 / 0.004314698497827655 0.016967272956506692 / 0.0066627404504453576 82 FAM129B_3 9_127531490_GA_G / 9_127525143_T_G / 9_127578821_C_G 0.000922821517572468 / 0.0002411893320187629 / 8.276570085958934e-05 0.031013612085774283 / 0.010661251800502545 / 0.0009666899162254512 83 SEC11C_2 18_59152698_T_C / 18_59139887_T_G 0.0009260156067678403 / 0.049013482279269986 0.0022574597582570113 / 0.007830715004334495 84 SERPINB6_3 6_2955641_A_C / 6_2955644_A_C / 6_2959401_A_C 0.001043382693355795 / 0.024971781697072672 / 0.0010045092345408332 0.01355817950847752 / 0.003892754006925403 / 0.039976665559382514 85 HEXB_5 5_74696581_T_G / 5_74696784_G_A / 5_74715459_CT_C / 5_74715716_T_A / 5_74715716_T_TA 0.0011109425360834742 / 0.0004588063308077307 / 0.00032306189000466006 / 0.0012875359612772113 / 0.013801634858228495 0.0076182846696747 / 0.037654298343869685 / 0.0009700644073606587 / 0.0006894634360309071 / 0.008716125756790354 86 CHAF1A_5 19_4431899_C_T / 19_4442339_C_T / 19_4443049_T_C / 19_4422720_A_G / 19_4442532_T_C 0.0013371878989745694 / 4.704638650715319e-06 / 0.002601657035134123 / 0.00848724820837247 / 0.0008277326854784058 1.913287638550038e-06 / 2.142565869765625e-07 / 2.294297809586175e-06 / 0.024620616607439628 / 0.010330162535447171 87 DTNBP1_5 6_15522870_T_C / 6_15662701_T_G / 6_15524467_T_C / 6_15637909_C_A / 6_15651411_GA_G 0.00140727662017035 / 0.0007340285829190258 / 0.000563588210134313 / 0.0015365486679584585 / 0.012631556103580063 0.02838345350893315 / 0.001004314451212422 / 0.0038345211108275156 / 0.02038116210082405 / 0.0014349866138238813 88 NPC1_6 18_23533587_A_G / 18_23531466_TG_T / 18_23543332_G_GA / 18_23556539_A_C / 18_23551637_T_C / 18_23540944_CT_C 0.001437129484746987 / 7.150026947753571e-05 / 0.0029007221429512673 / 0.0002201554381797956 / 0.00283655966462793 / 0.003557570436749789 0.049542946772028126 / 0.03680603821841593 / 0.0011845211365567286 / 0.011218938268584914 / 0.00977392034448968 / 0.040822963170832685 89 DCK_2 4_71023678_G_A / 4_71023683_A_T 0.0025792753639569685 / 0.004519208391207111 0.0495745351142595 / 0.03292890320415958 90 MYOF_5 10_93402739_A_T / 10_93341723_C_T / 10_93456833_C_T / 10_93359764_G_A / 10_93379679_T_C 0.0031553117726987327 / 0.0003251886046767745 / 0.0012115888716542418 / 0.0011033881652818386 / 1.1152022033742226e-05 0.008275987890594253 / 1.0154009952651607e-05 / 4.5730649026336375e-05 / 0.04572104850464974 / 0.0006543495060757152 91 CNOT6L_4 4_77720488_T_G / 4_77819455_A_C / 4_77720486_A_G / 4_77726534_A_C 0.003413275456645043 / 0.004884718330098437 / 1.3017900050261066e-05 / 0.013675885143940456 0.00045440611666765506 / 0.0041059419980858354 / 0.003812687853894012 / 0.002323583718729919 92 SNX24_2 5_122845530_G_A / 5_123023772_TA_T 0.003825812212204896 / 0.005412166991196986 0.032851178784777335 / 0.010215103992736332 93 SQSTM1_4 5_179833153_C_T / 5_179833213_G_A / 5_179822433_T_C / 5_179832842_G_C 0.004089948495769615 / 0.007896407107059047 / 1.0391418374918043e-11 / 5.901642675392869e-07 0.014656854055438881 / 0.015290841042493631 / 0.0024949336391905503 / 0.0024314650981475784 94 CTTN_7 11_70419876_A_C / 11_70419880_T_C / 11_70433755_A_G / 11_70433765_G_C / 11_70407283_C_T / 11_70433037_T_G / 11_70435435_C_T 0.004793877560857165 / 0.0029267237988671235 / 0.0002662301400632249 / 2.1853977605406948e-05 / 5.710606729324503e-07 / 0.00010373335018763256 / 0.002764146814493288 0.00030309409522359497 / 0.003131141961303907 / 0.02047999046614251 / 0.008528354106314544 / 0.005941149857145408 / 0.004388396641544275 / 0.013709818259161087 95 KDM2B_4 12_121580903_A_C / 12_121579943_C_CA / 12_121444386_T_G / 12_121580252_TG_T 0.004804220239616889 / 5.298915204579247e-06 / 7.807472174797022e-08 / 0.024172279934987287 0.04290936139558865 / 0.01794421156168876 / 0.019501973878425127 / 0.004964292850525796 96 CTNNA1_4 5_138812304_T_G / 5_138824633_A_C / 5_138933920_C_T / 5_138812289_C_G 0.005041441550878414 / 0.009914746459480685 / 0.00032076772718977635 / 0.013542487211798218 0.013339032203366944 / 0.004284224604488671 / 0.00010488952235634391 / 0.0010251811268691103 97 TRIOBP_2 22_37751927_A_C / 22_37757383_C_G 0.0053165450762140245 / 0.0016386338499532257 0.008760146502383994 / 8.295724649894844e-05 98 EGR1_2 5_138467153_A_C / 5_138466811_A_C 0.005590395913285018 / 0.00018684738505679937 0.006707694887573882 / 0.00027393305226194143 99 MYCBP2_8 13_77070727_G_A / 13_77165156_A_T / 13_77098982_T_G / 13_77051091_G_A / 13_77051098_A_C / 13_77058230_T_G / 13_77061586_T_C / 13_77267898_T_G 0.008036895878308711 / 0.012181733375411912 / 0.0004449974043640469 / 0.0007742974469162077 / 0.004690941013903492 / 0.022811552981952272 / 0.0002327215378800939 / 0.004205585533754351 0.029852585169277374 / 0.00045980757332588846 / 0.0038229074053839733 / 0.00017518564876142542 / 4.397700485560215e-05 / 0.0032117224925540928 / 0.030373685856290068 / 0.00592396173483849 100 TCF4_6 18_55464257_C_A / 18_55463971_TGTGTGTGA_T / 18_55275657_A_G / 18_55275664_A_G / 18_55403517_A_C / 18_55461237_G_T 0.008090959269238968 / 0.0056178520760126974 / 0.001559758175866868 / 0.012472558742737408 / 0.0011862271176169732 / 0.006912522905586032 0.032420073593804284 / 0.03333184670009802 / 0.0013930308437610063 / 0.00619762753769391 / 1.5397131093463103e-06 / 0.04572000946513434 101 LAMC1_3 1_183132309_A_C / 1_183131203_C_T / 1_183131172_CAA_C 0.008181813089040216 / 3.4320876665108484e-05 / 0.02745630451997897 0.01655294869349123 / 0.03400723316751987 / 0.002417084109353407 102 DCBLD2_2 3_98800637_G_A / 3_98822022_G_A 0.00885632710582371 / 0.003195091628487625 0.02405283820151249 / 0.02321925017861924 103 FAM114A1_2 4_38905545_G_A / 4_38905553_A_G 0.008914101428030875 / 9.057397575383816e-05 0.004385515653682114 / 0.0017226027017899913 104 RXRA_2 9_134379472_C_A / 9_134432274_T_C 0.01212893284996885 / 0.0010613625702847742 0.008306707838893354 / 0.02628295923936911 105 TXNL4A_2 18_80033872_T_C / 18_79988525_A_C 0.013055851849266827 / 0.0007334523399616647 0.0008431735834914795 / 0.0008431735834914795 106 PLOD1_3 1_11957799_T_G / 1_11958607_A_C / 1_11949823_T_G 0.016423562694112787 / 0.0001256608005905079 / 0.00021455234639659347 0.008642421166450967 / 0.04289731210522306 / 0.033198246352540164 107 ZBTB40_2 1_22508509_T_G / 1_22490438_G_C 0.019306644087308318 / 0.0028404969140742 0.007412910007401148 / 0.034427044070664166 108 LAMB1_4 7_107937003_CT_C / 7_107937011_T_C / 7_107932321_G_T / 7_107962914_G_C 0.02001404015878396 / 0.03127808008490267 / 2.518001172595479e-05 / 0.001938778625683203 0.0036685711722291453 / 0.0056496711183904105 / 0.008417008915963444 / 0.03562871053322305 109 ZNF407_2 18_74635526_T_C / 18_74631665_A_C 0.02054827360868693 / 0.0027671214071800644 0.0030145474545959137 / 0.0007578348015755224 110 PLK2_2 5_58457156_TA_T / 5_58459186_CA_C 0.02678606136810066 / 0.011492772698233265 0.0067079016563832035 / 0.009712841903254471 111 ITGAV_6 2_186622542_G_T / 2_186637080_T_G / 2_186637084_A_G / 2_186602110_C_T / 2_186665096_ATTT_A / 2_186665096_ATTT_AT 0.02893229553935201 / 1.7690277512995773e-05 / 5.7650114136378393e-05 / 0.0008794014178128033 / 0.0009612996704148748 / 0.0001992070205841996 0.0007084667177580308 / 0.001139110475330106 / 0.032143834630956734 / 0.02901306245899837 / 0.02901306245899837 / 0.044847327779240435 112 TPP2_4 13_102649187_G_T / 13_102654868_C_T / 13_102663598_G_C / 13_102663763_G_A 0.03448812010250688 / 0.0477208297438401 / 0.019367023504440688 / 0.03879139461694567 0.0003388682906380855 / 0.0002674729630147893 / 5.0196213345567326e-05 / 0.0001694198597404117 113 EGFR_2 7_55205133_G_A / 7_55205662_A_C 0.03713506709789649 / 0.0018125796749231603 0.003745674667154008 / 0.0007797573368817686 114 FAM57A_2 17_733080_T_TCTC / 17_733026_A_AGGGCC 0.039798318296646464 / 0.015321230586696297 0.00016240672631849488 / 4.5958865963508443e-05 115 RBFOX1_2 16_7676807_A_C / 16_7653705_T_G 1.089283918433845e-06 / 0.009933638723622762 0.017746981967786752 / 0.040139058541755146 116 PLEC_10 8_143935900_T_G / 8_143916360_A_G / 8_143917054_T_G / 8_143917234_T_G / 8_143918739_A_C / 8_143919099_A_G / 8_143925385_A_C / 8_143919088_C_G / 8_143927138_G_A / 8_143930 1.2060887811693293e-09 / 0.0045339553290741135 / 0.000104533588224814 / 1.7757593439950334e-05 / 0.00011641011921845986 / 1.9686417676937634e-05 / 0.006102754107095385 / 0.01695040934478527 / 0.039180192965724406 / 0.017591680187249745 0.0004960012901022363 / 0.00910116635228719 / 0.025072704488480143 / 0.013279688389245713 / 2.138708286444241e-05 / 0.0010288222361061275 / 0.0062995698781779215 / 0.009415988048366521 / 0.008162873576760793 / 0.001268625363946227 117 ACTN1_2 14_68904620_A_G / 14_68879945_C_A 2.2790061519900746e-05 / 0.002826959920374089 0.01924890787722053 / 0.03820518094606298 118 YES1_2 18_724697_A_C / 18_732727_A_G 2.3090624801719088e-05 / 0.007129044591559579 0.008883311549914912 / 0.026256278963938562 119 SMARCC1_2 3_47662444_T_G / 3_47735913_C_T 2.3383243293118917e-06 / 0.002421910157609216 0.0017680794934126945 / 0.01814701077813162 120 LMNA_2 1_156139242_AT_A / 1_156138783_A_G 2.3951192128687798e-05 / 0.0022551444971150103 0.04237931129547261 / 0.040758441980734486 121 CCND1_2 11_69650913_A_G / 11_69651969_C_G 2.86821845503723e-06 / 0.0004216841283241181 0.024298615321604846 / 0.021515769887785408 122 SMARCA4_3 19_11025539_C_G / 19_11025639_C_T / 19_11059900_G_C 3.0403566208171576e-05 / 9.60336281664007e-06 / 0.00028978302130045137 0.00029624992802644123 / 0.02706216606857304 / 0.035243495124704975 123 KMT2C_7 7_152273692_G_A / 7_152235860_C_T / 7_152145265_T_G / 7_152152848_C_A / 7_152177504_T_G / 7_152236218_G_A / 7_152152869_A_G 4.1091183934080156e-05 / 0.03814263508657298 / 0.010803753158495692 / 0.018128565763915704 / 0.001183790631102062 / 0.008327722660599219 / 0.017441444102837326 0.02044755694417402 / 0.00015664974968742393 / 0.0030671124260532785 / 0.00028670765106413883 / 0.0007976241891358237 / 0.0009326888762057726 / 0.008191480303636886 124 PXN_2 12_120219856_A_C / 12_120219864_A_C 4.578278108445838e-05 / 0.0074220837424624425 0.0003630643828121584 / 0.0023389819820739933 125 BCOR_2 X_40052275_A_C / X_40074609_T_G 4.939704915952993e-09 / 0.0027449638737320047 0.00020414397606395237 / 0.02744186131378764 126 FLI1_2 11_128810729_A_G / 11_128810736_G_C 5.306393173162265e-05 / 0.004212940238900314 1.6562593178924343e-05 / 1.4658089385344776e-05 127 LAMB2_4 3_49121431_A_C / 3_49126013_T_G / 3_49125146_T_G / 3_49121239_T_G 5.5170807525836925e-05 / 0.03902097870402451 / 7.419230761410297e-05 / 0.003164093062093864 2.9470349723526757e-05 / 0.002569958840604656 / 0.002569958840604656 / 0.028556312248339717 128 HMGA2_2 12_65841991_CT_C / 12_65838525_G_A 5.57550946086e-05 / 0.039914434884169736 0.032926686839147117 / 0.00575414262140414 129 ZNF708_3 19_21294577_C_T / 19_21309149_T_A / 19_21309260_G_A 5.694223127781568e-05 / 9.010844850080123e-06 / 0.0003481251422158083 0.007544201865148675 / 0.008126720123629898 / 4.891895383413758e-05 130 ASPH_2 8_61578734_T_G / 8_61578968_A_C 6.56790692451237e-08 / 0.0009758798617439217 0.00027481062695969863 / 0.0029272870469332557 131 CCAR1_5 10_68737016_C_A / 10_68736998_A_C / 10_68747386_A_C / 10_68749170_A_C / 10_68747145_CT_C 8.229773536774104e-06 / 0.007146867657347806 / 0.0011117731660420908 / 0.0013852137674061765 / 0.003664158474067453 0.003954046326130957 / 0.005283569468845993 / 0.002868590533518923 / 0.044268019704288585 / 0.007417608363424872 132 DOCK1_3 10_127008567_ATAACT_A / 10_127248024_G_T / 10_127414990_T_G 9.077419985352092e-05 / 0.0002745710836507499 / 0.00705137247255559 0.0011610761862802675 / 0.020184142497530616 / 0.047170945666414485

Table 17 shows the biomarkers associated with EGRF drugs and the degree of reactivity (P-value) of the drugs by the tables.

In [Table 17], FRH was expressed in the form of "FRH name_number of markers included", and "Var_Drug (pval)" means the correlation (P-vlaue) value of the corresponding marker on drug reactivity. According to the order of reactivity, the correlation value for each drug is divided into the division factor 『/』, and 『Var_Exp (pval)』 means the correlation (Pvlaue) value that each marker has on the corresponding gene expression. , Also, according to the order of the markers, the values of the reactivity correlation for each drug are classified by the classification factor 『/』.

From these reactivity verification results, it can be determined that the lower the Var_Drug (pval) and Var_Exp (pval), the higher the effectiveness of the corresponding marker as a biomarker for determining drug reactivity.

Meanwhile, in FIG. 39, correlation values (P-vlaue) values of EGRF drugs of major biomarkers among the biomarkers described in [Table 17] are displayed in a graph.

Reactive biomarker for EGRF drug and verification result of reactivity with drug No. FRH Variants Var_Drug (pval) Var_Exp (Pval) One CWC27_1 5_64977191_G_A 2.20E-08 0.002090721 2 RNF217_1 6_125082793_A_C 3.96E-08 0.0374208 3 PTGR1_1 9_111597344_C_A 8.25E-08 2.15E-05 4 NTN4_1 12_95738117_A_G 1.53E-07 0.019702457 5 ZNF276_1 16_89737928_T_C 1.72E-07 0.019670045 6 THBS1_1 15_39587486_A_C 2.59E-07 0.031233094 7 TRIM29_1 11_120115474_C_A 3.52E-07 0.011023929 8 APBB1_1 11_6401118_A_C 7.48E-07 0.04449344 9 RASA3_1 13_113981629_G_A 1.35E-06 0.009453296 10 TMX3_1 18_68700489_TA_T 1.39E-06 0.003224589 11 RRP1_1 21_43791417_C_A 1.65E-06 0.034182877 12 SIT1_1 9_35650461_G_A 1.75E-06 0.019947873 13 FRG1_1 4_189955114_T_C 2.25E-06 0.018901776 14 GTF2IRD1_1 7_74512993_A_G 3.54E-06 0.006481631 15 DCP1A_1 3_53342054_G_C 4.78E-06 0.003471409 16 SNRNP70_1 19_49101556_A_C 5.20E-06 0.016599779 17 DDX20_1 1_111756207_T_C 5.26E-06 0.008003234 18 TJP2_1 9_69237088_T_C 5.58E-06 0.04386431 19 RHOJ_1 14_63269236_T_G 6.18E-06 0.027885215 20 CXCL2_1 4_74098975_A_C 7.13E-06 0.000838562 21 CARD8_1 19_48212012_T_C 9.03E-06 0.00020501 22 TRMT2A_1 22_20117296_A_C 9.03E-06 0.048556634 23 CRIM1_1 2_36479368_G_C 9.53E-06 0.012444715 24 ELF3_1 1_202010991_C_G 9.65E-06 0.017391595 25 UHRF2_1 9_6482002_G_T 1.20E-05 0.007025127 26 HDHD2_1 18_47115026_C_T 1.42E-05 1.48E-06 27 ZBTB17_1 1_15944765_G_A 1.47E-05 0.010171388 28 THRB_1 3_24143504_G_A 1.80E-05 0.026515077 29 DHRS3_1 1_12568430_G_A 1.81E-05 0.043238329 30 AGTPBP1_1 9_85672687_TA_T 1.94E-05 0.017580094 31 DMTF1_1 7_87166631_TAG_T 1.97E-05 0.010040428 32 CTBP2_1 10_124993226_T_G 2.02E-05 0.022707139 33 BLK_1 8_11543171_G_A 2.24E-05 0.01145612 34 EPCAM_1 2_47373742_AT_A 2.57E-05 0.033377716 35 JUN_1 1_58782229_T_C 2.65E-05 0.037758558 36 RBM5_1 3_50114164_G_T 2.77E-05 0.00111984 37 CDKN2AIP_1 4_183445476_T_TGCACA 2.77E-05 0.002734488 38 ZCCHC7_1 9_37302158_C_T 2.93E-05 0.022389727 39 RAB8B_1 15_63262625_GTA_G 2.96E-05 0.020562837 40 ODC1_1 2_10444350_A_C 2.98E-05 0.031377929 41 CLTB_1 5_176397682_T_C 3.11E-05 0.006127908 42 UIMC1_1 5_176906125_C_T 3.66E-05 0.014840456 43 HCST_1 19_35903545_A_C 3.71E-05 0.031562304 44 HSPA1B_1 6_31828722_C_G 3.82E-05 0.018774385 45 MYL12B_1 18_3261766_G_T 4.16E-05 0.002628021 46 RHBDF1_1 16_63885_G_GCC 4.21E-05 0.04101508 47 UBE2N_1 12_93411182_C_T 4.29E-05 1.51E-06 48 SVIL_1 10_29524582_A_G 4.44E-05 0.010981597 49 CCDC28B_1 1_32202026_A_C 4.45E-05 0.031117706 50 ADARB1_1 21_45182568_CT_C 4.48E-05 0.049945862 51 PPP4R1_1 18_9549876_A_G 5.09E-05 0.004893788 52 CHD1L_1 1_147294440_C_G 5.10E-05 0.048656291 53 LRP5_1 11_68424878_T_G 5.20E-05 0.010363624 54 RND3_1 2_150487464_GA_G 5.77E-05 0.009852344 55 LONRF1_1 8_12731670_C_A 5.98E-05 0.001411904 56 BCOR_1 X_40052275_A_C 6.09E-05 0.000204144 57 CCT8_1 21_29070160_C_T 6.54E-05 0.02571665 58 ZNF330_1 4_141232702_CTT_C 8.61E-05 0.012329326 59 CEP128_1 14_80916501_C_A 8.82E-05 0.001156052 60 SH2D3A_1 19_6760997_A_G 9.99E-05 0.028745239 61 IRF6_1 1_209790735_C_T 0.000103095 0.008136801 62 ITGAL_1 16_30484175_C_T 0.000109049 0.037227837 63 UEVLD_1 11_18558312_C_A 0.000112934 0.026771319 64 RNF141_1 11_10530725_T_C 0.000116417 0.011923468 65 THRAP3_1 1_36288866_G_C 0.000117571 0.000131738 66 PIAS4_1 19_4028785_C_T 0.000120052 0.024864531 67 SLC22A5_1 5_132390655_C_A 0.000123083 0.004292176 68 JAG1_1 20_10648877_T_C 0.00012714 0.02148436 69 SPI1_1 11_47358510_A_C 0.000133865 0.03491009 70 TECPR1_1 7_98223587_A_G 0.000136841 0.023100583 71 ZC3HC1_1 7_130023656_C_T 0.000136956 0.010175357 72 PDGFA_1 7_518698_G_C 0.000139135 0.000252407 73 C16orf74_1 16_85741569_G_A 0.000148491 0.001823033 74 DOT1L_1 19_2226677_G_A 0.00015451 0.006191812 75 CD19_1 16_28937656_A_C 0.000155088 0.031114669 76 P2RY2_1 11_73235099_G_C 0.000158117 0.045669577 77 EHF_1 11_34661000_T_C 0.000158117 0.017992198 78 EPS15L1_1 19_16392488_A_C 0.000158117 0.033272384 79 AGTRAP_1 1_11750007_T_G 0.000159275 0.049159238 80 LYRM7_1 5_131199511_CT_C 0.000164473 0.021278948 81 EPAS1_1 2_46346944_T_G 0.000170063 0.018667654 82 SIX4_1 14_60713618_C_T 0.000180476 0.049844478 83 PROM2_1 2_95281185_T_G 0.000190311 0.033838771 84 CAPN1_1 11_65186241_T_G 0.000194914 0.02936405 85 SRRM1_1 1_24669380_C_A 0.000202713 0.019718891 86 KLF3_1 4_38689006_A_C 0.000228896 0.015121455 87 THSD4_1 15_71765130_A_C 0.000239788 1.95E-06 88 GPR107_1 9_130129853_A_G 0.000243505 0.033022802 89 TCERG1_1 5_146471685_A_C 0.000246294 0.042046343 90 ATG4C_1 1_62805167_G_T 0.000259178 0.028589986 91 SHQ1_1 3_72750552_C_T 0.000259737 0.005940284 92 DSG2_1 18_31524751_A_G 0.000261765 0.009944093 93 S100A14_1 1_153615226_C_T 0.000274681 0.01787459 94 CLDN4_1 7_73830773_C_T 0.000293995 0.000682466 95 OVOL2_1 20_18041767_A_G 0.000295117 0.047118131 96 CREB1_1 2_207577759_AT_A 0.00029854 0.000463006 97 BCLAF1_1 6_136278266_T_C 0.000301864 6.60E-05 98 PKP2_1 12_32791480_G_T 0.000343509 0.006486331 99 ADAM9_1 8_39082624_ATTT_A 0.000344695 0.022961 100 POLA1_1 X_24743203_T_G 0.000351661 0.028975018 101 FBXO10_1 9_37537560_G_A 0.000376887 0.024540631 102 CHMP4B_1 20_33811394_C_G 0.000388769 0.00409862 103 NOP56_1 20_2657708_GT_G 0.000405654 0.000313483 104 WIPF1_1 2_174585550_T_G 0.000407518 0.000483959 105 SCNN1A_1 12_6349108_G_C 0.00042455 0.003465155 106 C11orf80_1 11_66828178_C_T 0.000427492 0.010017428 107 ERP27_1 12_14914577_T_TGTGC 0.000433389 0.018734323 108 JAG2_1 14_105151295_T_G 0.000452695 0.00756224 109 SMARCC1_1 3_47693210_A_G 0.00046021 6.92E-05 110 RNF138_1 18_32123591_T_C 0.000469129 0.018606829 111 THYN1_1 11_134248640_G_T 0.000477172 0.042214253 112 CYP24A1_1 20_54164725_T_C 0.000480706 0.013922674 113 SH2D3C_1 9_127766923_A_C 0.000489816 0.042455713 114 TGFA_1 2_70453242_T_G 0.000497539 0.011508647 115 CXCL16_1 17_4738773_T_G 0.000507631 0.000457547 116 AEN_1 15_88629905_A_C 0.000523617 0.014580971 117 SLC37A1_1 21_42534616_T_G 0.00054592 0.025393921 118 EPHA2_1 1_16148437_A_C 0.000564393 0.003022958 119 BCS1L_1 2_218660859_A_G 0.000567546 0.011564609 120 FBXO43_1 8_100137711_G_C 0.000602338 0.026281824 121 ADAM22_1 7_88075657_C_T 0.000632153 0.041287227 122 ADAMTSL1_1 9_18636052_G_T 0.000649915 0.010200615 123 ATXN2L_1 16_28834263_C_T 0.000652099 0.023519932 124 ZCCHC4_1 4_25313024_A_C 0.000669769 0.022993547 125 BCL2_1 18_63318646_T_C 0.000676626 0.021320439 126 EGR1_1 5_138466811_A_C 0.000686817 0.000273933 127 HS3ST1_1 4_11399218_T_C 0.000704542 0.027639734 128 LEF1_1 4_108078210_G_A 0.000716837 0.012727304 129 SRSF7_1 2_38748190_GT_G 0.000734347 0.005863144 130 KHSRP_1 19_6415784_T_C 0.000787917 0.003576751 131 YPEL1_1 22_21704297_T_C 0.000796764 0.006311112 132 TAPT1_1 4_16162866_G_A 0.000802167 0.000763967 133 SNRK_1 3_43348277_C_T 0.000817875 0.00952899 134 UGCG_1 9_111932206_A_G 0.000846657 0.012775358 135 DBF4B_1 17_44709262_G_C 0.000856709 0.025236345 136 HOOK1_1 1_59860373_C_G 0.000856894 0.041888498 137 ITGB3BP_1 1_63572436_G_T 0.000871324 0.023830002 138 DTX4_1 11_59205028_T_C 0.000886385 0.025332013 139 PPP1R13L_1 19_45391868_T_C 0.000894105 0.005877508 140 CBLC_1 19_44790103_A_C 0.000937082 0.025305244 141 B4GALT4_1 3_119212822_G_T 0.000987069 8.97E-06 142 HSBP1_1 16_83809462_C_T 0.000990234 0.008673739 143 DTX1_1 12_113093500_A_T 0.001029524 0.02107386 144 TMEM51_1 1_15219789_A_C 0.001061315 0.004570596 145 ASAP2_1 2_9388476_A_C 0.001065564 0.013740425 146 PPP2R3C_1 14_35096667_C_A 0.001070573 0.008848084 147 WWC2_1 4_183280995_G_T 0.001131955 0.017164588 148 DMKN_1 19_35505819_C_T 0.001187435 0.023762682 149 EPHX1_1 1_225838589_T_G 0.001193048 0.015600736 150 PRPF4B_1 6_4051933_C_A 0.001231599 0.023843897 151 SNRNP40_1 1_31267793_A_G 0.001239539 0.0334327 152 LTBP3_1 11_65543062_T_C 0.00124246 0.027887632 153 BAG3_1 10_119651803_A_C 0.001254787 0.031179453 154 ANKRD2_1 10_97572685_T_G 0.001261251 0.014732168 155 ZNF451_1 6_57147971_C_A 0.001263762 0.000340137 156 ME2_1 18_50920583_C_T 0.00130336 2.53E-06 157 DLG5_1 10_77811963_T_G 0.001305738 0.016910687 158 USP19_1 3_49111457_T_C 0.001383111 0.008511689 159 PDCD11_1 10_103433899_A_G 0.001419074 0.023046171 160 PDE1B_1 12_54577030_T_G 0.0014774 0.000907902 161 LONP1_1 19_5707040_C_G 0.001478061 0.014919269 162 KCNN3_1 1_154733143_A_C 0.001483801 0.012755172 163 FSD1_1 19_4304543_G_C 0.001495716 0.036857163 164 F2RL1_1 5_76832874_T_G 0.001535054 0.000269192 165 XPO4_1 13_20787374_T_C 0.001546207 0.044182604 166 TM4SF1_1 3_149375342_T_G 0.001551483 0.005766355 167 NPAS1_1 19_47035965_T_G 0.001567313 0.037858765 168 FAM78A_1 9_131260861_G_A 0.001574494 0.029873205 169 SYTL2_1 11_85734802_A_C 0.001576085 0.007792297 170 TMEM57_1 1_25431052_T_G 0.001577095 0.001041181 171 TUBA1A_1 12_49186397_T_C 0.001584541 0.019746043 172 ITPR3_1 6_33692820_C_T 0.001625448 0.001333145 173 ATM_1 11_108317650_T_C 0.001633198 0.007926126 174 SGTA_1 19_2769109_A_C 0.001653712 0.041785185 175 LCORL_1 4_17883673_A_AAC 0.001662772 0.000314326 176 MTDH_1 8_97660911_G_GATA 0.001694886 0.048360283 177 IKBKB_1 8_42320656_T_C 0.00170984 2.52E-05 178 HNRNPD_1 4_82355277_C_CA 0.001737277 0.049911299 179 RAX_1 18_59272671_A_C 0.001739655 0.028250861 180 ZNF775_1 7_150397902_A_C 0.001751147 0.01910485 181 ALDH1A3_1 15_100885169_T_G 0.001758148 0.04003907 182 GNAI2_1 3_50252193_A_C 0.001785905 0.005183043 183 ZNF740_1 12_53187645_C_G 0.001788461 0.049202233 184 NTM_1 11_132307846_G_T 0.001796239 0.000193861 185 CHN1_1 2_174801578_A_G 0.001797358 0.038050415 186 PAX5_1 9_36923611_G_A 0.001934236 0.014759026 187 VAMP3_1 1_7781489_A_C 0.00200626 0.040313352 188 STK4_1 20_44995009_C_T 0.002049488 5.24E-05 189 USP24_1 1_55075675_C_A 0.002073268 0.008980628 190 EXOSC10_1 1_11080567_C_A 0.002083377 0.019692529 191 TINAGL1_1 1_31585380_T_G 0.002085646 0.037138102 192 SPTLC3_1 20_13093456_G_T 0.002145546 0.024467108 193 PLEKHA6_1 1_204257921_A_C 0.002162143 0.049362899 194 PLXNC1_1 12_94219931_T_G 0.002163508 0.043558201 195 CAPN2_1 1_223717830_G_A 0.0022465 0.020893773 196 TJP1_1 15_29718124_TA_T 0.002277416 0.026903818 197 ASPHD2_1 22_26442326_G_A 0.002296851 0.029916144 198 IFT43_1 14_76082206_T_G 0.002305612 0.012552105 199 CASK_1 X_41578463_T_G 0.002309184 0.043343775 200 C21orf33_1 21_44144829_C_T 0.002316139 0.047114252 201 AFAP1L2_1 10_114294856_CCTAA_C 0.00232372 0.037962739 202 MEI1_1 22_41699656_A_C 0.002354824 0.019192604 203 HAUS6_1 9_19080551_G_A 0.002357763 0.027262757 204 LRRC8E_1 19_7899842_G_A 0.002381607 0.011668019 205 SMARCB1_1 22_23787366_GGC_G 0.002396307 0.000127894 206 DUT_1 15_48332272_A_C 0.002405318 0.00018263 207 MON1A_1 3_49911902_A_G 0.002439566 0.010543368 208 SASH1_1 6_148440274_CT_C 0.002448515 0.046157021 209 MAP1S_1 19_17726640_A_C 0.002527497 0.022464441 210 TOE1_1 1_45340381_G_A 0.002528538 0.048016234 211 CNOT7_1 8_17242848_C_T 0.002530932 7.40E-11 212 CD244_1 1_160836124_G_A 0.002583957 0.026316972 213 EPM2AIP1_1 3_36992730_A_C 0.002610713 0.00113706 214 PRSS16_1 6_27249457_C_T 0.002649855 0.041003068 215 GPSM3_1 6_32192179_T_C 0.002655487 0.017253689 216 UGDH_1 4_39527132_G_A 0.002672816 0.035973223 217 AIG1_1 6_143060973_T_C 0.002697343 0.001184612 218 PMS1_1 2_189864380_G_A 0.002709035 0.028805775 219 PTGFR_1 1_78497752_G_A 0.002814073 0.008690688 220 AGPAT2_1 9_136674614_A_G 0.002858165 0.022967509 221 CBL_1 11_119278299_T_G 0.002995636 0.015544213 222 RAB37_1 17_74694690_G_A 0.003050869 0.017656336 223 GTPBP3_1 19_17338111_A_C 0.003059974 0.000709713 224 HDAC4_1 2_239053232_A_C 0.003067942 0.036469606 225 MBD3_1 19_1577118_C_T 0.003069952 0.001822739 226 CEP170_1 1_243164906_G_A 0.003157617 0.005533907 227 S100A16_1 1_153607964_A_G 0.003160582 0.026054854 228 DCK_1 4_71022615_CT_C 0.003222902 0.021365647 229 INF2_1 14_104713013_A_C 0.003224544 0.022440089 230 MYO6_1 6_75870526_T_C 0.003249199 0.022167818 231 CDS1_1 4_84635369_T_A 0.003299427 0.032630939 232 CTDSPL_1 3_37980672_C_T 0.003333659 0.043268165 233 EPB41L1_1 20_36187855_G_T 0.003410098 0.042407864 234 FGR_1 1_27617489_T_A 0.003443717 0.014581374 235 CAPRIN1_1 11_34051813_A_G 0.003553009 0.001206062 236 FOXC1_1 6_1612184_TA_T 0.00358795 0.004712911 237 ARHGEF6_1 X_136685627_G_A 0.003598733 0.001837929 238 BCAR3_1 1_93674923_G_C 0.003606528 0.049870881 239 BCL9L_1 11_118897861_A_C 0.003681075 0.034238861 240 TMEM201_1 1_9610425_T_A 0.003707837 0.025977963 241 RPS11_1 19_49496985_C_T 0.003720736 0.048243831 242 GMEB1_1 1_28690201_G_T 0.003734863 0.005247117 243 XRCC5_1 2_216109182_G_C 0.00380529 0.019360584 244 IL13RA1_1 X_118776541_G_T 0.003874528 0.009303333 245 PRR14_1 16_30651924_T_G 0.003882844 0.041861928 246 SH2B3_1 12_111418260_C_G 0.003991404 0.00753988 247 DTNBP1_1 6_15662698_A_G 0.00400197 0.006306033 248 PADI1_1 1_17228910_T_G 0.004006843 0.013302935 249 FAF1_1 1_50787989_A_G 0.004030148 0.030848308 250 RAB11FIP5_1 2_73075763_G_GGCCT 0.004085081 0.024778824 251 ZBTB40_1 1_22508509_T_G 0.004115308 0.00741291 252 BLCAP_1 20_37517746_T_C 0.004121218 0.011965638 253 KIF2A_1 5_62373627_T_G 0.004150384 0.036674489 254 HCFC1_1 X_153963207_T_G 0.004154957 0.001579155 255 HINFP_1 11_119121467_T_C 0.004250524 0.04539997 256 PRDM2_1 1_13823349_T_A 0.004303676 0.011003429 257 EIF4E_1 4_98902074_AT_A 0.004333629 0.008214508 258 PARVG_1 22_44206294_C_G 0.004424 0.028583204 259 COX18_1 4_73064835_G_A 0.004489575 0.009081073 260 WDR33_1 2_127701640_C_G 0.004497758 0.006721664 261 ARHGAP9_1 12_57474460_G_A 0.004523019 0.041357487 262 GGCX_1 2_85550432_A_G 0.004614743 0.015128917 263 ZNF182_1 X_47983350_T_G 0.004661316 0.045101518 264 ANXA6_1 5_151117292_C_T 0.004727288 0.038173193 265 RPL14_1 3_40457950_G_A 0.004955666 0.001218496 266 FCHO2_1 5_73082876_ATT_A 0.004962427 0.029256929 267 RAB28_1 4_13473790_TATC_T 0.004968595 0.040901005 268 RNGTT_1 6_88769645_C_T 0.00502562 0.002545266 269 NNT_1 5_43602611_T_C 0.005081886 0.030151517 270 CLDN1_1 3_190308594_C_T 0.005105908 0.019956392 271 NRN1_1 6_6003752_C_T 0.005133833 0.006175355 272 ZNF423_1 16_49635837_A_C 0.005155281 0.015077717 273 YES1_1 18_732727_A_G 0.00519113 0.026256279 274 RAPGEF6_1 5_131433731_GA_G 0.005213959 0.0053626 275 MGAT4B_1 5_179799918_A_G 0.005262946 0.044186289 276 GATAD2B_1 1_153818250_T_C 0.005279052 0.026743921 277 FCRL5_1 1_157518564_T_C 0.005397526 0.023539142 278 ACSS2_1 20_34925819_A_C 0.00560253 0.016776881 279 CTR9_1 11_10773884_CAAAAA_C 0.005625384 0.03664895 280 INPP5B_1 1_37872885_G_T 0.005738649 0.010365859 281 RPAIN_1 17_5421266_TTC_T 0.005740177 0.041469888 282 RCHY1_1 4_75509142_T_A 0.00575286 7.00E-06 283 RASSF7_1 11_562335_A_C 0.005935904 0.018138357 284 NKX3-2_1 4_13541263_A_G 0.00596504 0.000419444 285 IGFBP3_1 7_45917562_GT_G 0.006141827 0.045400401 286 LTBR_1 12_6385217_T_C 0.006192879 9.81E-05 287 GNG2_1 14_51950694_A_C 0.006226032 0.02637487 288 NAP1L1_1 12_76084896_T_C 0.006264126 0.018182577 289 GULP1_1 2_188589974_C_CT 0.006362476 0.004507263 290 PXDC1_1 6_3727577_C_G 0.006364895 0.027367829 291 WDR12_1 2_202897546_T_A 0.006402216 0.044170968 292 TMBIM6_1 12_49742405_G_A 0.006435087 0.019471463 293 PPM1D_1 17_60656452_CA_C 0.006580355 0.01692061 294 RPA2_1 1_27907061_GA_G 0.006586873 0.02798096 295 PRR3_1 6_30562126_T_G 0.006592704 0.005676599 296 RBM28_1 7_128310614_C_A 0.006924451 0.019795754 297 ENAH_1 1_225519569_GAAAA_G 0.007036997 0.048924277 298 KIAA0922_1 4_153592379_A_G 0.0070597 0.048688528 299 TRIM2_1 4_153276097_A_G 0.007183471 0.011894098 300 ATP8B1_1 18_57731374_T_C 0.007320467 0.035819404 301 QSOX1_1 1_180178802_A_G 0.007420273 0.008203943 302 MB_1 22_35607296_C_G 0.007592955 0.045421658 303 ORAI2_1 7_102433548_G_A 0.007786599 0.035889292 304 WNT7B_1 22_45931386_G_A 0.007831858 0.025701725 305 PIKFYVE_1 2_208330748_GT_G 0.007852983 0.009816454 306 ARHGAP32_1 11_128972609_T_G 0.007895267 0.007875634 307 SH3YL1_1 2_249571_C_T 0.007939764 0.043096755 308 DEPDC5_1 22_31843912_CT_C 0.00801665 0.025230811 309 VSIG10_1 12_118073908_T_G 0.008024404 0.001976122 310 SLX4_1 16_3595722_A_C 0.008031231 0.013087513 311 REEP3_1 10_63621980_A_G 0.008035335 0.03021965 312 FARSB_1 2_222571709_T_C 0.00812224 0.037339824 313 NDUFS3_1 11_47578800_A_G 0.00843631 0.008511324 314 HIBADH_1 7_27538786_G_A 0.008437431 0.025866827 315 SCLT1_1 4_128957191_A_C 0.008485976 0.015508556 316 SLC20A2_1 8_42439475_C_T 0.008560526 0.001296999 317 LMO7_1 13_75855483_C_A 0.008616687 0.000790188 318 SREBF2_1 22_41897136_G_C 0.008665061 0.031235978 319 SPAG1_1 8_100194395_C_A 0.008766072 0.025833604 320 NCAM1_1 11_113270137_A_G 0.008796809 0.040540565 321 ATP1B1_1 1_169111407_C_G 0.008822814 0.015890801 322 PLXNB2_1 22_50281752_C_G 0.008850507 0.048268974 323 PFAS_1 17_8269414_A_G 0.008856682 0.026137416 324 CEP152_1 15_48762574_G_C 0.008866418 0.044026406 325 GNRH1_1 8_25423267_A_G 0.009056061 0.039449902 326 CARD10_1 22_37508612_T_C 0.009110799 0.021324272 327 COL6A3_1 2_237351090_T_G 0.00914922 0.009459532 328 RBM12B_1 8_93733158_G_T 0.009183374 0.012443278 329 ITPKC_1 19_40737666_A_C 0.009205546 0.045257656 330 ARHGAP31_1 3_119390922_C_T 0.009221747 0.042725387 331 GRAMD1A_1 19_35022992_C_T 0.00930255 0.030347265 332 SAE1_1 19_47131056_T_G 0.009443122 0.006083296 333 MICALL1_1 22_37924607_T_G 0.009460572 0.025017274 334 GABRB2_1 5_161336809_G_A 0.009484795 0.019276169 335 SPINT2_1 19_38287977_A_G 0.009500965 0.018521267 336 ATXN7_1 3_63990247_A_C 0.009623217 5.97E-05 337 TATDN2_1 3_10248824_C_CT 0.009659313 0.000116552 338 AP4E1_1 15_50968319_T_G 0.009752147 0.046599506 339 CHST2_1 3_143121243_A_G 0.009892538 0.040099833 340 PRKAG2_1 7_151560579_A_G 0.009896448 0.024618763 341 C16orf45_1 16_15596596_T_G 0.009927037 0.04351851 342 SULT2B1_1 19_48591514_T_G 0.009943382 0.006727275 343 DSTN_1 20_17600864_A_G 0.009947784 0.000427203 344 TPD52L2_1 20_63889961_A_C 0.010191021 0.005896198 345 E2F2_1 1_23521217_C_G 0.010495212 0.008957912 346 TSEN34_1 19_54192354_T_G 0.010854598 0.001848481 347 FOXN3_1 14_89162512_A_C 0.011014558 0.001249668 348 MND1_1 4_153408912_G_GTATATA 0.011263008 0.006400349 349 ZDHHC5_1 11_57696028_T_C 0.01129582 0.000204877 350 ARMCX4_1 X_101488321_C_G 0.011422104 0.008157752 351 P2RY11_1 19_10115376_G_A 0.011466091 0.000105991 352 C1orf198_1 1_230839028_T_C 0.011890625 0.008759206 353 TPTE2_1 13_19425773_G_A 0.011929579 0.00812417 354 TMEM206_1 1_212379769_G_C 0.01195192 0.000739419 355 REEP5_1 5_112891583_T_A 0.012573055 0.001996089 356 CNNM4_1 2_96798981_T_G 0.012933399 0.000393837 357 GPR65_1 14_88011069_C_T 0.013002947 0.005376071 358 ZDHHC7_1 16_84981848_T_G 0.013133304 0.007398316 359 KCNAB3_1 17_7925552_G_A 0.013376003 0.008474756 360 ASNSD1_1 2_189670812_C_T 0.013663903 0.004106264 361 LY9_1 1_160814485_A_C 0.014209114 0.004017681 362 SKIV2L2_1 5_55307994_T_C 0.01489715 0.008290134 363 MADD_1 11_47325027_T_C 0.01504914 0.001497343 364 ITPRIPL1_1 2_96325641_T_G 0.0151793 0.004828474 365 SDC4_1 20_45330303_T_G 0.015973482 0.000496261 366 SLC2A8_1 9_127398490_G_A 0.016168742 0.003968261 367 CSF2RB_1 22_36923285_A_C 0.016450302 0.008060727 368 WWTR1_1 3_149669685_C_T 0.016674011 0.040303211 369 PEX10_1 1_2410431_A_C 0.017756279 7.19E-05 370 SCMH1_1 1_41033845_T_G 0.01786284 0.006455807 371 WNT10A_1 2_218882471_A_C 0.018148757 0.008633339 372 SIRT4_1 12_120303510_G_GAA 0.018478224 0.002426212 373 SLC25A43_1 X_119451980_A_G 0.018546868 0.000927303 374 SLC35F5_1 2_113723196_TA_T 0.019332514 0.009792442 375 PLEKHA5_1 12_19369550_A_AAAAG 0.019740309 0.004535622 376 RASEF_1 9_82982805_CAGAG_C 0.019798987 5.81E-06 377 RASSF2_1 20_4797919_T_G 0.019937429 0.007153311 378 ANKRD44_1 2_197099965_G_A 0.020081182 0.009634061 379 ZFYVE19_1 15_40812591_A_AAG 0.020142634 0.000177529 380 TMEM2_1 9_71704688_T_G 0.02064031 0.00528138 381 TMEM159_1 16_21174063_G_A 0.020994925 0.001734513 382 PEX13_1 2_61045783_A_T 0.021004523 0.005293964 383 BCAR1_1 16_75229126_T_A 0.021029307 0.004775721 384 SLC25A38_1 3_39389590_G_A 0.021402491 5.21E-05 385 ING5_1 2_241711916_A_C 0.021779734 0.000297693 386 AHR_1 7_17339074_A_C 0.021825994 0.009928124 387 ETV1_1 7_13900838_A_C 0.022234699 0.00028392 388 FUS_1 16_31191353_T_G 0.022580325 0.000527105 389 ELMO1_1 7_36986095_A_C 0.022675843 0.000582138 390 FLI1_1 11_128772826_T_G 0.022696029 2.10E-08 391 RBPJ_1 4_26321137_C_A 0.023026755 0.005948758 392 TGM1_1 14_24260894_A_C 0.023877255 4.06E-05 393 MAD2L2_1 1_11680485_C_A 0.024343193 0.005401081 394 CCDC66_1 3_56613771_T_C 0.024734355 0.00694013 395 E2F3_1 6_20402547_A_C 0.024779926 0.001096854 396 TRIM47_1 17_75875198_A_C 0.025043777 0.006990418 397 LACTB2_1 8_70657773_A_C 0.025193805 0.000265188 398 S100A13_1 1_153619154_A_C 0.026872567 0.000285894 399 PRKCZ_1 1_2059508_T_G 0.027355157 0.000553783 400 KIAA0430_1 16_15601202_A_G 0.027767771 0.008344755 401 PARP1_1 1_226377365_T_C 0.028078591 0.000660394 402 VMP1_1 17_59841357_A_C 0.028144116 0.00700708 403 TRPM7_1 15_50619668_AT_A 0.028234282 0.007696192 404 RPL11_1 1_23695353_C_A 0.028842665 0.006999268 405 RHPN2_1 19_33002924_G_A 0.02894401 0.001694408 406 MAST3_1 19_18107675_A_T 0.028979003 0.002887665 407 SACS_1 13_23354711_A_C 0.029483838 0.007436264 408 ZBTB4_1 17_7463332_C_G 0.030579241 0.009123992 409 SSH3_1 11_67309455_A_C 0.031167208 0.006068708 410 STAU1_1 20_49153934_T_C 0.031695969 0.047157357 411 PRSS22_1 16_2853046_G_C 0.032478102 0.003660773 412 SRRD_1 22_26488073_G_A 0.03313164 0.001986837 413 ITGB8_1 7_20399120_C_G 0.033295835 0.000193939 414 FLII_1 17_18245630_C_G 0.033989678 0.00994433 415 TMEM40_1 3_12769284_C_T 0.034416268 0.003842868 416 SLC19A1_1 21_45512453_A_C 0.034642487 0.009916208 417 FBN1_1 15_48425289_G_T 0.035154355 0.007224526 418 TMC4_1 19_54160564_G_A 0.03557474 0.008695606 419 TACC2_1 10_122132454_G_A 0.036645036 7.09E-05 420 HEATR5A_1 14_31315848_T_C 0.037815962 0.000583004 421 SLC25A24_1 1_108161212_C_T 0.038139179 0.001625377 422 TMEM39B_1 1_32091713_A_C 0.038513492 0.008701631 423 ANKRD22_1 10_88831974_A_C 0.039475145 0.00796284 424 SFSWAP_1 12_131753058_C_G 0.039748632 0.004289964 425 C1orf54_1 1_150279750_G_C 0.039956255 0.001281485 426 SEPT10_1 2_109564377_G_T 0.040053757 0.00487648 427 FOS_1 14_75280999_A_C 0.04011469 0.001488063 428 AARS2_1 6_44301927_CAGG_C 0.041166243 0.004966986 429 EMP1_1 12_13211531_T_G 0.041461108 0.001600571 430 FBXO2_1 1_11648995_C_G 0.042445462 0.005932397 431 UBE3A_1 15_25408653_C_A 0.044428109 0.002080316 432 GPC1_1 2_240451007_T_G 0.044965723 0.007919222 433 ACTN4_1 19_38728028_T_G 0.045229843 0.005408687 434 EPB41L4B_1 9_109182980_T_C 0.045378555 0.002429073 435 SERTAD3_1 19_40441466_GGATC_G 0.045415799 0.001465832 436 WHSC1L1_1 8_38315857_G_C 0.046096872 0.004506209 437 QRICH1_1 3_49076524_TAAA_T 0.046339149 0.007356338 438 CAMSAP3_1 19_7618018_A_C 0.046801001 0.000416732 439 TCHP_1 12_109907472_T_G 0.047094137 0.003720466 440 TUFT1_1 1_151565936_G_A 0.048675231 0.004559558 441 CHMP1A_1 16_89649256_C_T 0.048695701 0.003804631 442 LAMB2_1 3_49125146_T_G 0.049754671 0.002569959 443 PNRC2_1 1_23961290_GCTT_G 0.049756672 0.006024417 444 MARVELD2_1 5_69419733_A_C 0.049786079 0.007668831 445 SLC22A18_3 11_2919250_T_G / 11_2903361_G_A / 11_2919268_T_G 0.00010006113410040524 / 0.0011537278855378685 / 0.03948380156101269 0.003253241739951185 / 0.009485355002003664 / 0.004588734004408302 446 SH3D19_3 4_151148254_TACACACACACACACAC_T / 4_151122202_T_C / 4_151148202_G_T 0.00010065962678441032 / 0.015768562077467373 / 0.0009087951468125592 0.016052772944150497 / 0.00026537095134489047 / 0.004030165987762314 447 LARS2_5 3_45474156_T_C / 3_45476267_G_A / 3_45488909_G_A / 3_45500591_T_C / 3_45417241_A_G 0.00010374784857743111 / 3.7424426310272928e-06 / 1.2434210249182578e-07 / 6.432927229497336e-08 / 0.004689576487598519 1.1453239774161183e-13 / 9.671821420877082e-13 / 6.257680298053254e-14 / 4.345853387032865e-14 / 0.022164736928693304 448 SRGAP1_2 12_64142411_T_C / 12_64097222_GTT_G 0.00010959539878441124 / 0.0011886231256692465 0.006505852651723906 / 0.02613509690642953 449 ALDH3A1_3 17_19742310_G_A / 17_19748298_C_T / 17_19740913_C_G 0.00011241479007533596 / 0.0023838380538555946 / 0.026511359318080838 0.016065461057378518 / 0.04852415829065191 / 0.0007153928676742558 450 LPIN3_5 20_41345676_A_G / 20_41358461_T_G / 20_41358465_C_G / 20_41340873_C_A / 20_41350009_T_G 0.00011710984250539265 / 0.000846270947552816 / 0.0063262440202536815 / 7.192100726008128e-05 / 0.033798727519866234 0.001902884670314011 / 5.712471333190794e-05 / 6.891802498643105e-05 / 0.025739865299148755 / 0.0036707505113827256 451 LAMB3_3 1_209626885_C_T / 1_209626996_C_T / 1_209630438_C_T 0.00012286163323842149 / 0.0001560650413956853 / 0.00010264198687506551 0.014463355479842403 / 0.005725629984184445 / 0.0254414675884508 452 RAC1_2 7_6398689_A_C / 7_6401802_T_G 0.00012312607987750062 / 0.022378677686989437 0.0005959472772163739 / 0.003141262984465143 453 CERKL_2 2_181603835_A_C / 2_181678048_T_G 0.00012332912254087272 / 0.00048702996607960313 8.976196985876391e-05 / 0.010552400468127526 454 MTO1_2 6_73492090_C_T / 6_73473277_C_CAGAT 0.0001242869571724915 / 0.027975699490295474 0.0009500421967262693 / 0.0034299441619718607 455 SUMF1_2 3_4419885_G_A / 3_3846683_A_C 0.00013129129316308624 / 0.007888292383663753 0.017506933739797337 / 0.0026519652256760252 456 WDFY4_5 10_48946696_T_C / 10_48774557_A_C / 10_48823427_C_T / 10_48826590_T_A / 10_48709976_C_T 0.00014298234740370438 / 7.877438075749654e-06 / 0.006750199117687904 / 0.008731995024502738 / 0.0057882693531272345 0.03553981554074815 / 0.02592605078891659 / 0.041159506689191376 / 0.03934434383747865 / 0.036092320181802036 457 DSC2_3 18_31091249_T_G / 18_31093490_T_G / 18_31080273_C_T 0.00014328639925920681 / 0.026176748525728964 / 0.004444668756137834 0.002053875263128439 / 3.7895626071773765e-05 / 1.9855794171946574e-05 458 MBD1_4 18_50276088_C_A / 18_50276601_A_G / 18_50275492_T_G / 18_50275430_G_A 0.00014793743904567252 / 0.01877342572270696 / 0.003092273916220477 / 0.0033406482616730533 0.002775832151787685 / 0.0007205116796968372 / 0.027183042271681262 / 0.047488972926164726 459 KIAA1671_2 22_25029373_T_C / 22_25170874_A_C 0.00015698694769979702 / 0.0006020288880688977 0.04147687852552058 / 0.03878706897291035 460 MET_3 7_116740945_T_G / 7_116757685_T_G / 7_116740947_C_G 0.00016797515698396606 / 0.002832945772163542 / 0.002231117554658809 0.00017295700570667475 / 5.0554093231126755e-05 / 0.0012218666498089645 461 RCBTB1_2 13_49585356_T_A / 13_49533768_G_A 0.0001756869709333519 / 0.009455073314037034 0.02533885676009956 / 0.019692263494698818 462 PPL_4 16_4883459_A_G / 16_4894423_G_C / 16_4901058_T_G / 16_4891747_T_G 0.0001758787943382569 / 0.0007098905861696843 / 0.0005647077594982514 / 0.011689794335935037 0.009286392985327631 / 0.04550405331166151 / 0.01682150071796396 / 0.0032410422551606864 463 TMEM63A_3 1_225856800_GC_G / 1_225856891_C_T / 1_225845173_C_T 0.00017631469170194104 / 0.0005047149993335916 / 1.5371108451049484e-05 0.04262290781357216 / 0.031894233309554584 / 0.039853481810337744 464 KDM4B_5 19_5110783_A_G / 19_5047680_G_A / 19_5111856_C_T / 19_5152376_T_C / 19_5114105_T_G 0.00018149502531503815 / 0.0011449297013059851 / 3.0255655048228253e-05 / 0.0056532335440754155 / 0.005029743152006167 0.0038743952075057523 / 0.0010649511420676163 / 0.008640482718151363 / 0.012419815562589162 / 0.0315424322762135 465 TAF4B_2 18_26286027_C_A / 18_26293570_AT_A 0.0001933876544072626 / 0.0006065453361074753 0.005234163638807017 / 0.02416136973363145 466 MAP2K7_3 19_7905750_A_G / 19_7911231_T_C / 19_7910579_A_C 0.00020437876506728577 / 5.172101478935253e-05 / 6.985639899444967e-05 0.026466975715454883 / 0.014436739312155004 / 0.014559538606612087 467 EGFR_5 7_55160480_C_T / 7_55170771_T_G / 7_55205133_G_A / 7_55181370_G_A / 7_55205662_A_C 0.00020841604787297526 / 0.00045465182013688124 / 0.02209047666362801 / 0.00015707737069901731 / 0.0019734565993096485 0.042584839287283 / 0.004588325394927623 / 0.003745674667154008 / 0.030349772078527886 / 0.0007797573368817686 468 MED4_2 13_48079728_CAAA_C / 13_48077399_A_AT 0.00021592440051490123 / 0.00970359638804136 0.028274397927711425 / 0.04285821577494423 469 PSMG1_2 21_39183425_G_C / 21_39175728_T_C 0.00022608775731841645 / 0.012584465994979182 0.00513068025831651 / 0.006708397725563725 470 SYMPK_3 19_45823908_G_A / 19_45835234_G_A / 19_45842628_T_C 0.0002277738548719044 / 7.560389488032653e-05 / 0.007665716537369837 0.03948007686982654 / 0.026714512477614062 / 0.0420060391850977 471 CNKSR1_6 1_26180299_A_G / 1_26181802_G_A / 1_26181989_T_C / 1_26183270_A_C / 1_26184255_A_C / 1_26180691_T_G 0.00022855371657961118 / 0.000553633072814145 / 0.004976293349453925 / 0.0012311577321858017 / 0.00011380023959208459 / 2.366839986118124e-05 0.0031268776228605263 / 0.042309660108738684 / 0.031585176815995236 / 0.007340521806393782 / 0.03620130672603948 / 0.0014019419704167026 472 LGR4_3 11_27373900_C_T / 11_27380156_G_A / 11_27368981_G_A 0.00022889582425503487 / 0.00022889582425503487 / 7.68908468665983e-05 0.02925705779271898 / 0.02925705779271898 / 0.007261247877037425 473 VTCN1_3 1_117157003_C_T / 1_117172345_T_C / 1_117172578_ATTT_A 0.0002510217205927707 / 8.944919469827468e-06 / 0.016016251707355836 0.03055768777478911 / 0.023227355162109414 / 0.001594504991034824 474 CRBN_6 3_3151010_G_T / 3_3152273_A_C / 3_3154589_AT_A / 3_3175444_AT_A / 3_3179746_C_T / 3_3150840_A_ATAAC 0.0002626503373527541 / 0.013274951670738794 / 7.062286693324899e-05 / 0.0004048382754165016 / 0.003012811333138018 / 3.124023410218089e-05 0.0018118056645904023 / 0.00018124433406194467 / 2.1732312542326866e-07 / 7.214198132928058e-05 / 1.1224125713318842e-06 / 3.115850854605648e-06 475 SMCHD1_5 18_2707621_G_A / 18_2724932_A_T / 18_2763699_C_T / 18_2656105_T_G / 18_2795854_A_G 0.00026503656166190905 / 0.009320150621080624 / 0.0042306245640629115 / 0.025865035105419227 / 0.0001080554536414254 7.290016375189198e-05 / 0.03677531412547839 / 0.02250972081801197 / 3.289863234127764e-05 / 0.037011899642268684 476 HDAC11_2 3_13496579_C_G / 3_13496863_T_TG 0.00027757125208069643 / 0.00015267586088891374 0.0271728892750038 / 0.0149184097594151 477 PIK3CD_4 1_9720778_T_G / 1_9721354_C_G / 1_9722498_C_T / 1_9710297_C_T 0.00030314689537509136 / 7.877458405180158e-05 / 2.4181398805762395e-05 / 0.002966501395718009 0.0012148539768169404 / 0.04037203630033394 / 0.011926248274336807 / 0.011351289482054416 478 GCDH_3 19_12891586_G_C / 19_12891749_T_G / 19_12899706_A_G 0.000306793254674835 / 0.0003686903209515677 / 0.009343822168831345 0.0326186066813529 / 0.03376530749875928 / 0.00026130883839357806 479 SEC11C_2 18_59152698_T_C / 18_59158845_T_C 0.00030911539588566946 / 0.00956493460787828 0.0022574597582570113 / 0.029955010760308976 480 SAFB_2 19_5667193_AC_A / 19_5668433_GT_G 0.0003098805881779707 / 0.044739771014985504 0.002063538258127222 / 0.0026106809691974946 481 ATP6V1B2_3 8_20212278_G_C / 8_20218183_C_A / 8_20214681_A_G 0.0003172005709671975 / 1.980177091110716e-06 / 7.277973285376886e-05 0.001539493748390498 / 0.02168738622123026 / 0.025450124159694176 482 PUS3_4 11_125896149_C_A / 11_125896278_A_C / 11_125896309_G_C / 11_125896312_C_T 0.00031902172789162014 / 0.0016768215144890312 / 0.00019026344698916655 / 0.0006367828673033801 0.02249427642441209 / 0.03343255062895107 / 0.0192679955094738 / 0.02546202950317841 483 XDH_2 2_31383804_G_A / 2_31398732_T_C 0.00033628525023115955 / 0.007506095065621764 0.04221528923752448 / 0.006330815240399064 484 WDR7_4 18_56679573_T_G / 18_56781547_G_A / 18_56815915_A_G / 18_57027330_A_ACGGC 0.00034150498667130327 / 3.859660027634848e-06 / 0.002362739963128272 / 0.006245785108127786 1.7583606026050092e-08 / 0.0071713352600959014 / 0.003286339206119661 / 0.04783850584421885 485 GJB2_2 13_20189503_C_T / 13_20189241_T_C 0.00035796332888395017 / 0.008815817126700895 0.005240901157790961 / 0.03930064243744275 486 NFATC1_5 18_79486406_T_G / 18_79486978_G_A / 18_79449015_A_G / 18_79451175_T_C / 18_79467476_A_G 0.0003603073768446487 / 5.049273733042917e-05 / 0.02785434119032008 / 0.02220634088861789 / 0.0002507020345223831 0.018612271205492262 / 0.026732897678207176 / 0.0006549922975230749 / 0.0005874163668026321 / 0.003817175702412812 487 TMEM141_2 9_136791905_T_C / 9_136791680_A_G 0.0004169452454367874 / 3.984588209897019e-05 0.03333885281311693 / 0.020229651998436324 488 GON4L_3 1_155750010_A_G / 1_155813972_C_T / 1_155826993_A_G 0.0004229050700030183 / 0.009903573910672052 / 0.002653632924091959 0.014960076537640884 / 0.0034455240142541605 / 0.03840390796922083 489 THOC1_4 18_218753_C_A / 18_259800_G_GA / 18_264012_G_A / 18_260303_A_C 0.00043864187590166915 / 3.026788938964173e-05 / 6.794818264684467e-06 / 0.0036079810571773866 0.01174777561883113 / 0.04550027828580569 / 0.038030003830584136 / 0.031572528408919984 490 MOCOS_3 18_36268700_A_ATACAT / 18_36195408_G_A / 18_36195416_C_T 0.00045986586717034416 / 0.0014799368107284092 / 0.001731239408871138 3.5975000177046293e-13 / 0.007257645332317387 / 0.011340791435594116 491 TBC1D1_2 4_37920795_A_T / 4_38102880_CA_C 0.000488440493483436 / 0.0003703609091265926 0.005935046245136817 / 0.0040311926239692975 492 MYOF_6 10_93402739_A_T / 10_93335910_A_G / 10_93341723_C_T / 10_93349980_G_A / 10_93456833_C_T / 10_93379679_T_C 0.0005166123667663002 / 0.008644559399569549 / 0.030314897647199957 / 0.007378711399757192 / 0.014254715712501044 / 0.03684609798869681 0.008275987890594253 / 0.013383779511641422 / 1.0154009952651607e-05 / 0.013694532403103154 / 4.5730649026336375e-05 / 0.0006543495060757152 493 RBBP5_4 1_205096605_G_T / 1_205105296_C_T / 1_205121757_C_G / 1_205101436_A_G 0.0005227440198400762 / 0.00526416157273805 / 0.0030657012636972646 / 0.0013099169827028106 0.015139833707904771 / 0.008644227461685475 / 0.012113677398994695 / 0.04046396583686459 494 CLASP2_2 3_33577059_G_GA / 3_33684322_GA_G 0.0005299045117610777 / 0.035952102365944434 0.0005875510468728085 / 0.0001503619637647613 495 PHACTR1_2 6_13206050_C_T / 6_12749854_G_C 0.0005337924756049767 / 0.004317442990912475 0.00039532970764163586 / 0.035334891294853864 496 ANAPC4_3 4_25396670_G_C / 4_25396674_T_G / 4_25405734_A_G 0.0005663311621920986 / 0.0013075373037905336 / 0.0465779350486673 0.000361328058170187 / 0.03220079967613157 / 0.0019550422066677508 497 PSMD5_2 9_120820914_A_G / 9_120824459_T_G 0.0005809565738534683 / 0.0007453253514985393 0.02520354146772891 / 0.030923039758435706 498 ABCC3_4 17_50677651_A_G / 17_50687493_T_G / 17_50677654_A_G / 17_50661130_G_A 0.0006252991041556168 / 0.01577297864138986 / 0.003896335000953405 / 0.0010188260367160796 0.031817085633522264 / 0.0088751921752167 / 0.04421726142800319 / 0.010430910480796323 499 PDS5A_8 4_39826222_A_G / 4_39908552_GA_G / 4_39920322_A_G / 4_39928282_TCA_T / 4_39874433_GT_G / 4_39902522_ATT_A / 4_39922752_TAA_T / 4_39849438_CAA_C 0.0006804734038066716 / 0.0008478404674630213 / 0.0026866381085943365 / 0.00132808107004332 / 0.004772686052629922 / 0.0001500621143076567 / 0.007431666608049384 / 0.000683239660165417 0.013430761436295064 / 0.011566738826207195 / 0.012551712088653194 / 0.04498488242774648 / 0.0069892257136405615 / 0.002775620894064112 / 0.00845393532716467 / 0.015679705858385958 500 ARID1B_3 6_157084627_G_A / 6_157084796_G_A / 6_156779262_G_GCGC 0.0006899056725067633 / 0.00012305812201489173 / 0.003772804433314189 0.002480449952777213 / 0.003319459056638543 / 0.0297382920893214 501 ATP6V1D_2 14_67347484_T_C / 14_67347517_C_T 0.0006971003770886628 / 0.004311412775348075 0.0458931703260112 / 0.04673425843690365 502 TSPAN15_2 10_69506088_T_G / 10_69506076_T_C 0.0007322830521084773 / 0.005306461981362982 0.002401654647845401 / 0.00014212528801531312 503 MLH1_3 3_37007142_A_G / 3_37012077_A_G / 3_37042249_A_G 0.000740971042730754 / 0.00173625605182141 / 0.0001471514352872128 0.0011032555560560838 / 0.0188504234858543 / 0.00278116952700519 504 MCPH1_10 8_6563013_A_G / 8_6414878_G_T / 8_6415022_A_C / 8_6442011_A_G / 8_6444662_G_C / 8_6621439_C_G / 8_6621761_G_T / 8_6643023_C_T / 8_6643230_C_G / 8_6445504_G_ 0.0007930301578494862 / 0.00783515709942311 / 0.0010653421345075958 / 0.01109994940299345 / 0.01748605668447073 / 0.014338437252537204 / 0.004071842491061435 / 0.0006919647053001271 / 0.012376440045340064 / 4.6837103256950894e-05 0.013491192511465546 / 0.00030214631498362885 / 1.4308699249286362e-06 / 0.000801511853950485 / 0.0006599247173344139 / 0.00022140087416861568 / 6.162352636469756e-05 / 4.2830362262517274e-05 / 0.0016916243554951818 / 0.00023822828634849838 505 APLP2_2 11_130110790_G_A / 11_130141602_T_C 0.0008186783504663072 / 0.005144250183511083 0.0021295365540794004 / 0.003817157441436617 506 GDF11_2 12_55743444_T_G / 12_55743453_A_G 0.0008261007388543191 / 0.03983988128537546 0.0038399667498981156 / 0.009308695658692865 507 DHRS1_2 14_24296416_G_A / 14_24296478_G_A 0.0008309168215997886 / 0.0004203355659529219 0.0011625249597744401 / 0.0009759887418146756 508 HMBOX1_2 8_29019076_C_G / 8_29049138_T_G 0.0008669919525569822 / 0.03171806222754735 0.004301459569275475 / 0.002544858829830765 509 FAM129B_3 9_127525147_A_C / 9_127531490_GA_G / 9_127578821_C_G 0.0008771327036108232 / 0.0021288478614580747 / 0.0022519852618096852 0.020053464930431048 / 0.031013612085774283 / 0.0009666899162254512 510 SQRDL_3 15_45676245_C_G / 15_45659211_A_T / 15_45659215_T_A 0.0008907771597097484 / 0.0020094614120517293 / 0.009204846533756823 0.014234174047984662 / 0.023564046281648054 / 0.01334902621156353 511 PAWR_3 12_79621127_A_T / 12_79621127_A_C / 12_79690012_G_C 0.0008953392161992621 / 4.018282599405261e-05 / 0.00946824676498348 0.00916697548400727 / 0.004195646894367022 / 0.04023621560178265 512 ZMYM4_2 1_35386039_A_G / 1_35398970_A_G 0.0009255268514009688 / 0.0010268025209398274 0.047414902378186935 / 0.03220211892803819 513 PNISR_3 6_99400577_G_T / 6_99400380_A_T / 6_99400680_T_C 0.0009649647745143484 / 0.0007159697124499053 / 0.04773876660712681 0.00024058514444646938 / 0.04850971607266792 / 4.045878429706501e-05 514 KCTD1_2 18_26455686_TTTTG_T / 18_26455824_G_A 0.0009651254517760071 / 0.00044897282981570764 0.011878660133524677 / 0.022677959399150814 515 YEATS4_4 12_69360050_G_A / 12_69360067_T_C / 12_69365771_AT_A / 12_69359732_G_C 0.0009657838134951767 / 0.010865427433622845 / 0.00010196861904854136 / 0.004781622790417561 0.00020734016607029562 / 9.576513142549652e-05 / 0.005769237544482665 / 0.00015854860163792644 516 MYH14_4 19_50257459_C_G / 19_50268152_A_C / 19_50223372_A_C / 19_50210705_A_C 0.0009907478792200786 / 0.00031027234534027856 / 0.009603188672713292 / 8.610623849100771e-05 0.003155642857162157 / 0.02679430539669753 / 0.04503905394492344 / 0.01011266806040028 517 TNRC6B_3 22_40246081_G_A / 22_40322746_C_G / 22_40270313_CTT_C 0.0010055560691593062 / 0.007906209412661305 / 0.009164202590452458 0.0005779404176446281 / 0.0047436478866502065 / 0.0364705418337816 518 INTS9_7 8_28780706_C_T / 8_28787754_C_T / 8_28793781_A_C / 8_28793783_A_C / 8_28835266_C_T / 8_28775581_A_C / 8_28775811_A_C 0.0010081741289715016 / 0.004592362992120706 / 0.0005120698884621372 / 0.0002773767656391789 / 0.02714848429874154 / 0.00020236348372473448 / 2.4854306942254155e-05 3.2138156864211546e-07 / 5.188443093736729e-09 / 4.024976616918393e-06 / 2.0930318384840388e-05 / 1.818850464108077e-06 / 3.257318543578891e-07 / 0.018623738854211223 519 SLC9A2_2 2_102708404_T_C / 2_102683152_T_C 0.0010228970665369316 / 0.0005020081620733607 0.009615984790689362 / 0.009480536166577638 520 CABYR_2 18_24159761_T_C / 18_24143046_A_T 0.0010567833091170056 / 0.0014968601112293539 0.005047158957377522 / 0.04396847891686953 521 GTF3A_3 13_27435783_G_C / 13_27434894_G_C / 13_27424632_T_C 0.0011190222584791265 / 0.004681955550098893 / 0.007918207229892667 6.8305505569380366e-06 / 4.651074413645253e-05 / 0.009084963551764854 522 C17orf80_2 17_73243051_A_T / 17_73243095_T_G 0.0011654886198261731 / 0.004494422448579687 0.010085515976883222 / 0.004743723689710052 523 SMU1_3 9_33042147_G_GC / 9_33048282_A_C / 9_33062151_T_C 0.0011669696398791268 / 7.696816352170192e-06 / 0.01499894245869885 0.04706645923394905 / 0.031220105263435657 / 0.0036210535474734524 524 APP_3 21_25881669_T_G / 21_25982373_C_A / 21_26053118_T_G 0.0011674640267523098 / 9.245713138747127e-05 / 0.004308340981093568 0.0009005203285702301 / 0.013334900192842466 / 0.04036723851049838 525 SF3A2_2 19_2247907_A_C / 19_2248684_C_T 0.0012266864812599976 / 0.002990131415570729 0.0030981828107111728 / 0.0468855780292127 526 MCM3AP_14 21_46242985_CA_C / 21_46245202_GAAGA_G / 21_46254361_G_A / 21_46256797_G_A / 21_46257020_T_C / 21_46258860_A_G / 21_46261213_T_C / 21_46265873_T_C / 21_462660 25_A_G / 21_462_ 0.0012527393891514607 / 0.00036535930217642055 / 0.0024609384326425487 / 0.04643229751040803 / 2.118510728826028e-05 / 2.887414182548247e-06 / 1.05276826358399e-07 / 0.00025970635193207507 / 0.0005620952054741439 / 5.716570824504117e-0726 0.0002736694696369044 / 1.7616074069549246e-05 / 1.3003369428929314e-06 / 2.3123117180340123e-05 / 2.0562643179742515e-06 / 8.354163607590267e-05 / 0.00029806921327546384 / 5.3648509797744586e-06 / 1.5227506753175702e-05 / 7.2 511 625 / 1.858126949270524e-05 / 3.8129306546053804e-06 527 CLIP4_2 2_29160508_G_A / 2_29167435_A_G 0.001256177781998004 / 0.0032393618837062445 0.004054702946614456 / 0.02363327883448803 528 TSC22D1_3 13_44574373_G_T / 13_44574380_T_G / 13_44573675_A_G 0.001377124084836583 / 0.015722049040498624 / 0.02470162730235456 0.0064804726533923464 / 0.0020304861527569297 / 5.907708401459935e-06 529 PKP3_3 11_403980_G_A / 11_404317_C_T / 11_397331_G_C 0.0013876622699982295 / 0.016481995505848203 / 3.1228708373215485e-07 0.018674886861837936 / 0.009799627021991927 / 0.04880244320980319 530 CASP8AP2_4 6_89867828_C_A / 6_89846678_CT_C / 6_89854793_T_G / 6_89867387_T_G 0.0013957399418989352 / 0.0012351347166879073 / 0.01485793169450881 / 0.029929799896047743 0.004638447540709211 / 0.00012650141154496166 / 0.0049509957510286366 / 0.007919221858804896 531 SUGP1_3 19_19297181_T_G / 19_19320614_T_G / 19_19321154_G_T 0.001497727430536191 / 0.0019392453885837852 / 1.1604792778575085e-06 0.004713359874536658 / 0.0005015062282813169 / 2.8690586178505662e-05 532 MTMR14_2 3_9701714_TGGAG_T / 3_9688859_C_T 0.0015228522402605245 / 0.0034777774244127892 0.0064175485415249155 / 0.007328897092709648 533 RIOK2_2 5_97167674_T_C / 5_97179013_C_G 0.0015264299232640686 / 0.0009434563320843556 0.018107759921786072 / 0.01839083931192911 534 HCLS1_5 3_121631746_C_A / 3_121642799_G_A / 3_121642940_G_A / 3_121647276_C_T / 3_121647530_A_G 0.001531370286315401 / 0.007140010061027548 / 0.0056491920403494 / 0.0056491920403494 / 0.0033035345652737084 0.008666157872154578 / 0.028236059065420614 / 0.02925717871219745 / 0.02925717871219745 / 0.035251625940568736 535 USP20_2 9_129868385_TGAC_T / 9_129868775_T_C 0.001542609843192008 / 0.006644626432996628 0.028200134219961023 / 0.0362382211673806 536 OGT_3 X_71555839_AT_A / X_71555852_A_G / X_71556880_G_A 0.0015512975406232336 / 0.0006090442157279421 / 3.794330620993244e-05 0.03251106613283236 / 0.03051485289420325 / 0.02757062507023744 537 ILF3_4 19_10677068_C_G / 19_10683073_A_G / 19_10683954_G_T / 19_10689074_T_C 0.0015595887966999382 / 0.0008443307208163777 / 0.0014177004651836508 / 0.006992884477782401 0.02905299869911714 / 0.023662506952371584 / 0.024462171404793464 / 0.04401306590016355 538 AKAP17A_6 X_1593528_G_T / X_1593824_T_C / X_1593829_A_C / X_1593416_T_G / X_1599467_G_A / X_1601004_C_G 0.0016145426205006856 / 0.006626142886833432 / 0.0006549722036186197 / 1.3622821646377586e-09 / 1.4367220837077828e-05 / 0.0013113963664485734 1.7500984806304813e-06 / 0.004424305821371996 / 0.031339887946813465 / 0.0002164120997390045 / 0.0019808227552202268 / 0.022975239267281157 539 HLA-DPB1_25 6_33084838_T_C / 6_33086094_A_G / 6_33086100_G_A / 6_33086430_A_G / 6_33086431_C_T / 6_33086458_T_G / 6_33086503_T_C / 6_33086504_G_A / 6_33086525_T_C / 6_33084940_A_C / 6_33084942_G_A / 6_33084946_C_G / 6_33084959_G_A / 6_33086548_G_C / 6_33086623_T_C / 6_33086627_A_G / 6_33086636_T_G / 6_33086637_T_A / 6_33084934_T_C / 6_33086390_G_A / 6_33086399_T_A / 6_33086400_T_C / 6_33086554_T_C / 6_33086565_T_A / 6_33084918_T_G 0.0016170360777901915 / 0.035517335536449965 / 0.03859616732889496 / 0.0050484605719981115 / 0.006920322099559346 / 0.04723136941351201 / 0.01042058063158112 / 0.01982161136592692 / 0.004676661817713314 / 9.909297446240884e-05 / 0.00013864663028350917 / 0.0002553757712440544 / 0.00010148054048444211 / 0.0005733999890735651 / 0.001447191231242919 / 0.0006504207970493822 / 0.0014159972834331574 / 0.0011151099996242373 / 1.670066308093462e-07 / 0.002181120675090949 / 0.001551134422399547 / 0.001551134422399547 / 0.00018558558739674276 / 0.00027961484945332547 / 0.04098305035004495 .01738899621763897 / .0071970972262367875 / .0015085198751619124 / .009855204235078744 / .009159540445250336 / .0034148006003537623 / .0007725393378843376 / 0.00046914802311591013 / .0002211234236168895 / .01812705600921171 / .02551712776803155 / .02768815887474311 / .01961732896362046 / .00424548612011435 / .03272474670019398 / .034386513937956574 / .03829938821939845 / .02718298788851184 / .0008766728067700178 / .0010412174325617669 / 0.00027430911944352433 / 0.00027430911944352433 / .007068880728833383 / .0015589855961860727 / .0023729962607638784 540 ERBB2_7 17_39723335_A_G / 17_39725167_A_G / 17_39727303_T_G / 17_39723531_A_C / 17_39728154_A_C / 17_39709434_A_C / 17_39728753_A_G 0.0016350878443782172 / 4.136237081824547e-05 / 0.046602377151608726 / 0.0033861558195955052 / 0.0037588249676302338 / 0.03412502593916668 / 0.0037443415073794024 0.030443197190865717 / 0.016249088634527818 / 0.0009745478853255011 / 0.014043142620610086 / 0.002489169967351341 / 0.005151661954164628 / 0.0238332618696792 541 CNOT10_5 3_32773739_A_T / 3_32705030_A_G / 3_32717271_G_A / 3_32727933_TAA_T / 3_32704796_GT_G 0.0016526003311275095 / 0.0001231320148601887 / 0.00017728596732259782 / 0.009536795008099045 / 0.003991838672618705 0.0019461949221222566 / 0.0007110070373588129 / 0.0032142136890770555 / 0.009535253937430231 / 0.00725632017358903 542 BTAF1_3 10_91959744_A_G / 10_91959746_A_G / 10_92024732_G_GTTTTTTTGTT 0.0016639394777511788 / 0.017417232932444852 / 0.002725136934144748 0.0011854132574195902 / 0.002486161819230707 / 0.02294891315626264 543 KDM2B_2 12_121579961_G_A / 12_121444386_T_G 0.0016808767205032673 / 0.0018129427277068664 0.04715734536774355 / 0.019501973878425127 544 OSBPL8_3 12_76371622_A_G / 12_76459031_C_T / 12_76389816_G_A 0.001685976661542144 / 0.0019376612844524102 / 0.00034069060776455845 0.010145024239484482 / 0.023570151478943115 / 0.01081801975958232 545 SPATS2L_4 2_200477598_G_T / 2_200412421_T_G / 2_200477943_T_G / 2_200473083_GAA_G 0.0017077762924250339 / 0.005542406637614594 / 0.008957206491580714 / 0.02371288438579117 0.021972245787165747 / 0.03547678698863923 / 0.016080388811817628 / 0.0009052273948575811 546 KMT2C_2 7_152273692_G_A / 7_152177504_T_G 0.0017215770748878 / 0.0257040166730586 0.02044755694417402 / 0.0007976241891358237 547 C3_8 19_6679370_G_T / 19_6679500_C_T / 19_6679552_T_C / 19_6693625_A_G / 19_6710771_G_T / 19_6713164_G_C / 19_6713251_G_A / 19_6718376_G_C 0.0017242987096359706 / 0.011130009901872313 / 0.01112305118572054 / 0.03308700773309592 / 0.0007547726119911367 / 2.8401856724118085e-05 / 9.337374703033051e-05 / 0.00015757450123976866 0.021139612203482698 / 0.001328408206242609 / 0.0024788445051524576 / 0.009567716450671235 / 0.00949274728217466 / 0.015144191214707904 / 0.01135067374028043 / 0.013151961372936128 548 NFX1_3 9_33290534_A_G / 9_33290690_G_C / 9_33344254_T_A 0.0017340354418381332 / 0.00213071003554307 / 0.0008944872419168263 0.004533123491706767 / 0.03459515757598255 / 0.005356381351212509 549 KATNAL2_4 18_46963135_T_TGC / 18_46969062_T_TGC / 18_47028569_T_TGC / 18_47069438_A_T 0.0017826363249020844 / 0.0002158210829164119 / 0.002959998960433205 / 1.0166082620431142e-06 0.023566439092900897 / 0.042581318341999685 / 0.01792891562738572 / 0.04594422713064072 550 PLRG1_8 4_154538042_A_T / 4_154539961_T_C / 4_154540535_A_C / 4_154540996_A_T / 4_154544383_A_G / 4_154545783_T_C / 4_154546035_A_G / 4_154548807_G_GA 0.0017837327552204187 / 0.0022747756662197635 / 0.013232282684609756 / 0.006089524083842604 / 0.023466965037692716 / 0.011286717487280188 / 0.015766497021373137 / 0.001132424851953552 0.0025156591482322463 / 0.003876861205834139 / 0.008064183834782563 / 0.004736898325652559 / 0.004629934695328492 / 0.00625636632504058 / 0.006403275082048386 / 0.0051675452547446255 551 EDN1_2 6_12295840_T_G / 6_12295843_T_G 0.00181409210724337 / 0.0002763328454078789 0.024241257142762068 / 0.012273310260196891 552 RABEP1_2 17_5381248_TAA_T / 17_5361621_C_T 0.0018150712755665734 / 0.004152920156402154 0.007056745600928623 / 0.01880219353285387 553 RUNX3_2 1_24907301_T_G / 1_24907326_T_G 0.001835528705698884 / 0.0008816631461578386 0.0479402881785652 / 0.03367486268556343 554 ARID3A_2 19_929678_G_A / 19_965056_A_C 0.001844502898018781 / 0.0038221459346221604 0.0024448512910076343 / 0.038475803182823655 555 SETD2_6 3_47037622_G_A / 3_47083895_G_A / 3_47084411_A_C / 3_47084426_CT_C / 3_47101417_TCC_T / 3_47121171_A_G 0.0018886443163515503 / 0.0005724676673950148 / 0.0018507014329319895 / 0.002298087295161151 / 0.0018577181187481573 / 0.000573845912909288 0.000977617083994294 / 0.008205866594339892 / 0.008011204119723829 / 0.009083566444260623 / 0.0015764712914139378 / 0.0002475067417184235 556 MYO1E_4 15_59272288_G_C / 15_59223315_G_A / 15_59178167_C_T / 15_59138181_A_C 0.0019255092745879315 / 0.027929898310990055 / 0.00031389151980896725 / 0.04411515555617615 0.006181875879725325 / 0.0073567891788311425 / 0.014590984354000915 / 0.000506485287819266 557 SUGP2_5 19_19024510_A_G / 19_19025732_C_T / 19_18994964_G_A / 19_19026233_T_A / 19_19010089_T_G 0.001983285518752092 / 0.002941993796204625 / 0.01284029709782453 / 0.0020741831309949127 / 0.0008037924072482433 0.040831519054544435 / 0.008182273259557721 / 0.005749298256034085 / 0.007605074821863024 / 0.027745888328438603 558 KLHL18_3 3_47319581_T_G / 3_47344095_C_A / 3_47322481_G_T 0.0021891626387678365 / 0.0006911454072889093 / 0.0001458644297550943 0.013218876001835087 / 0.0063137500959640856 / 0.018113274866617776 559 TYSND1_2 10_70138599_C_T / 10_70140172_G_A 0.002210990629147794 / 0.0039640911222843436 0.009659099597965872 / 0.027700702531791875 560 EIF1B_5 3_40309993_C_T / 3_40311393_C_T / 3_40311934_CAG_C / 3_40311768_T_G / 3_40309649_C_G 0.0022271726409335488 / 7.503385234156634e-05 / 3.177548305907501e-05 / 2.1365604310883664e-06 / 0.006831469965345718 0.005496962588873379 / 0.0028348307389023737 / 0.0036905138907599726 / 3.949648255514959e-06 / 0.04857611284248277 561 C14orf79_2 14_104991443_T_G / 14_104992803_A_C 0.0022393155386724074 / 0.009479451263550959 1.7720854995940125e-07 / 7.586102006604381e-07 562 SLC52A3_2 20_761203_A_G / 20_763790_T_G 0.002271842149158581 / 0.0019785326127115858 0.0003747217630289052 / 0.003089764091274667 563 HDAC5_2 17_44087216_A_G / 17_44077102_A_G 0.0022775299741103626 / 0.009100177186215046 0.03161998848113075 / 0.021561030479614426 564 TCF7L2_4 10_112951117_C_T / 10_113165703_A_C / 10_113165557_GA_G / 10_113141157_T_G 0.0023062734857754803 / 0.006196689121801137 / 0.00015949311848004983 / 0.01042058063158112 0.01060529288873283 / 0.008309178089758909 / 0.04233413143117931 / 0.004504822920252362 565 DSP_2 6_7577915_A_C / 6_7581379_A_G 0.002345981327408041 / 0.02625851263459552 0.0018316675069518392 / 0.005935959963292785 566 GAS7_3 17_9943314_G_A / 17_9943407_C_A / 17_9940079_A_C 0.0024862474118096554 / 0.02161659825841676 / 0.01209844734945125 0.014304203615809547 / 0.007643530014898026 / 0.02182596122662912 567 ARHGEF5_5 7_144365079_A_C / 7_144371121_T_C / 7_144371117_T_G / 7_144364997_T_C / 7_144365475_T_C 0.0024945926126355923 / 0.02354548207827752 / 0.006211748094610735 / 0.002934715516170928 / 1.727507617843059e-06 0.02343547139067424 / 0.007520412833757487 / 3.130275501973943e-06 / 0.02778730920062768 / 0.003065464879158348 568 PTPRU_3 1_29275579_A_C / 1_29310715_T_G / 1_29255395_A_C 0.002539773248455689 / 0.0077226993558171956 / 0.0009778041944005973 0.007805553893565897 / 0.021084479691732515 / 0.046498222792818684 569 TTC39A_2 1_51288088_T_G / 1_51295930_G_T 0.002570863553329518 / 3.4909921895622464e-05 0.0009000808652072745 / 0.009859747746545187 570 KRT15_3 17_41516910_C_A / 17_41518370_T_G / 17_41518744_A_C 0.002573274763251264 / 0.011567941016623695 / 0.003420135618507444 0.005435309336568784 / 0.004600527769071169 / 0.020891294013713143 571 UBXN8_5 8_30744093_TC_T / 8_30744288_C_T / 8_30751256_A_G / 8_30751544_T_G / 8_30751561_A_T 0.002591192476579632 / 0.0006909486125387932 / 0.02443874890142141 / 0.03582659928743899 / 0.03582659928743899 1.0603773748192244e-05 / 4.865545060608271e-05 / 6.152112049146202e-05 / 3.811929186552625e-05 / 3.811929186552625e-05 572 SMARCA4_3 19_11003321_G_T / 19_11010261_C_T / 19_11026459_T_C 0.002630441388397466 / 0.010463060303081006 / 0.010088756192701873 0.010970724428159849 / 0.007818649393052565 / 0.008366105586796981 573 PSMD6_2 3_64018733_C_CA / 3_64023832_T_C 0.0026976125076584256 / 0.009878175034845338 0.010870617478385693 / 0.0044822108745555264 574 CCDC18_7 1_93226524_AAT_A / 1_93232665_C_G / 1_93180876_T_C / 1_93221838_T_C / 1_93239253_G_A / 1_93226314_TG_T / 1_93180563_T_G 0.0027123682464393244 / 0.0016657739488188466 / 0.0033797977817805816 / 0.0015978624867728733 / 0.002134999320804664 / 0.013590020119742256 / 0.003793743444563949 0.04835531632243841 / 0.0045740699346053185 / 0.00032147121850177287 / 0.0017542576026547778 / 0.0017542576026547778 / 0.003812032810040999 / 0.0440564257256616 575 MKRN2_2 3_12572367_T_C / 3_12576770_C_T 0.0027864675750747985 / 7.698740851570175e-06 0.0004133954800997532 / 0.00023875055451781275 576 POU2F2_2 19_42122415_A_C / 19_42116791_T_G 0.002831354927429977 / 0.00132487414614545 0.0009318465407261826 / 0.03195305321524156 577 CSNK1G2_2 19_1941300_C_CG / 19_1978367_A_C 0.002838297409364801 / 0.002057750736247525 0.0019266812436141687 / 0.04165592627236607 578 NADK_4 1_1754601_G_T / 1_1755504_T_C / 1_1755523_C_T / 1_1757030_C_G 0.0029196774804306136 / 0.0022487075080235863 / 0.0010425578675322944 / 0.004582127513664698 0.031872533533518106 / 0.005752610352558396 / 0.0031781335571060463 / 0.03556781287056178 579 CD151_2 11_837662_TG_T / 11_835877_C_T 0.003028852216804449 / 0.04104019245722205 3.3851264417503082e-06 / 0.005759250847020773 580 ATP5A1_9 18_46098069_T_C / 18_46086016_C_T / 18_46086895_T_C / 18_46086986_C_A / 18_46087562_T_C / 18_46088355_G_T / 18_46090014_T_C / 18_46098295_T_G / 18_46090084_G_T 0.0030434677700528394 / 0.0004952827031339936 / 0.007810554102540824 / 0.000648733348082285 / 0.013897849420604671 / 0.002385765549363269 / 0.0010062790676919331 / 0.005315177457540565 / 0.01959258956571804 0.0003047097440701736 / 0.0142075393191002 / 0.036323160579493724 / 0.013872652612254888 / 0.0036567482317310593 / 0.02085147005163321 / 0.01507674177782532 / 0.03454712220311499 / 0.007087269321528623 581 ACTR8_2 3_53876892_G_GT / 3_53876872_GA_G 0.003050264516832101 / 0.008934315374097621 5.979539416096826e-07 / 0.005988354207232076 582 KDM4C_3 9_7105548_G_C / 9_7170165_G_A / 9_7174813_T_A 0.003056285777006115 / 3.848309807154845e-06 / 0.028252899669062883 0.04853749604959928 / 0.04549941716484139 / 0.006907446061910031 583 AZI2_2 3_28331971_C_CA / 3_28340396_A_T 0.0031048857689516462 / 0.003592307504254993 0.014552320913166257 / 0.004305743220750069 584 SERTAD4_2 1_210241533_TC_T / 1_210241536_T_C 0.003132119859215549 / 0.009639231593611885 0.019963608830813308 / 0.006491338228956634 585 USP15_4 12_62302696_T_G / 12_62383784_G_T / 12_62404146_G_T / 12_62335441_G_C 0.0031338510061822643 / 0.014094139089898441 / 0.0031672583932668176 / 0.002293994252085232 0.00033081922207003954 / 0.0033557619531166464 / 0.00033479875073063453 / 0.039619833047337696 586 DOCK1_3 10_127012556_G_A / 10_127444251_G_A / 10_127248024_G_T 0.0031585127425178675 / 0.027688640963832358 / 0.0004879172723173928 0.004938898221400919 / 0.007801850145866487 / 0.020184142497530616 587 ITGB4_4 17_75736347_G_A / 17_75739839_G_A / 17_75742534_T_C / 17_75754823_A_C 0.003162157220078509 / 0.008328692436238487 / 0.007894779942929558 / 0.009860822677928005 0.01217344559335353 / 0.002457354260511787 / 0.01159864028497844 / 0.005496381411893582 588 ZDHHC17_2 12_76843188_G_A / 12_76815330_A_G 0.0032793703796479517 / 0.0004434027342669209 0.011228793208829205 / 0.0047926477879100746 589 STEAP4_2 7_88282586_G_A / 7_88283906_C_T 0.003287923696320924 / 0.0091566014690908 0.020956268813510096 / 0.020511289316670928 590 SON_2 21_33553093_A_C / 21_33553095_T_C 0.003287986051022628 / 0.0002182856164179604 0.023262781799198717 / 0.04085529307129965 591 SUZ12_2 17_31937449_T_G / 17_31937443_C_G 0.0032919118028606463 / 5.6901277653871055e-05 0.001414433092115542 / 0.02301260051890533 592 ZNF708_5 19_21294577_C_T / 19_21309149_T_A / 19_21309260_G_A / 19_21294601_T_G / 19_21310453_A_T 0.003305225750188495 / 0.0035049021956979373 / 0.004520698246333428 / 0.0002495831365867789 / 0.0067675270617948155 0.007544201865148675 / 0.008126720123629898 / 4.891895383413758e-05 / 0.0371668734968966 / 0.010566885319869566 593 NPAT_3 11_108173261_C_T / 11_108188273_T_C / 11_108222481_A_T 0.003344965508099712 / 0.00917775939993597 / 0.039703241026176714 0.002496786878352684 / 0.04574657942913745 / 0.0037813176541691743 594 HSPG2_4 1_21848107_A_G / 1_21857246_A_G / 1_21854055_T_C / 1_21885485_A_C 0.003347609104205378 / 0.0006068526113653472 / 0.003704007084337551 / 0.00357256954025205 0.02697977272492986 / 0.03734459078034153 / 0.0018455746031783011 / 0.028105372966297285 595 TOP2B_6 3_25618603_G_GT / 3_25620066_T_TA / 3_25630287_C_T / 3_25632344_A_C / 3_25632600_C_A / 3_25638247_T_C 0.0033763968792717173 / 0.008450908635462133 / 0.0012336549489001688 / 0.00024044846753362568 / 0.0010363758807633305 / 0.0007533307901546944 0.009406841430847504 / 0.006029442482514222 / 0.011303133266640238 / 0.01883862996744124 / 0.018119501937010576 / 0.00877690000990295 596 MUC16_3 19_8894929_A_T / 19_8979498_T_G / 19_8957088_C_T 0.0034029575974152395 / 0.00041258558252529193 / 0.001514661605616884 0.03041637790901308 / 0.002432253712629655 / 0.03213344574711092 597 TMEM144_3 4_158244471_A_C / 4_158253356_T_G / 4_158253361_T_G 0.0034876691228988683 / 0.0005647077594982514 / 0.0008326481477321537 8.607739077270522e-05 / 6.799118981257274e-05 / 0.0018072956471693355 598 SDC1_2 2_20204203_T_G / 2_20202279_A_C 0.003538404752618725 / 0.0156379764488537 0.012274967718012342 / 0.005607450656810002 599 RBM6_7 3_50054242_G_T / 3_50054246_C_T / 3_50054250_C_T / 3_50054257_G_T / 3_50054263_T_G / 3_50075177_T_G / 3_50066484_G_A 0.0035570559373772188 / 0.00580221866025999 / 6.528791603289091e-07 / 0.001554315699435568 / 0.0007276852324929738 / 0.008508212434548797 / 0.002518709860742996 0.0124136469122058 / 0.0004024483543288937 / 3.272618868931358e-05 / 5.8729619078742086e-05 / 0.00033057063887385755 / 0.000930075295183941 / 0.014325869585835831 600 FIP1L1_2 4_53377738_T_C / 4_53414538_G_GA 0.003618394551763958 / 0.000808630514933739 0.020612870650917825 / 0.014620279830838013 601 BAZ1A_6 14_34773800_G_A / 14_34761774_C_T / 14_34761902_A_T / 14_34771458_C_G / 14_34780118_A_G / 14_34862082_G_A 0.003674207621815091 / 0.00048794862757524084 / 0.0004529362621637724 / 0.00048794862757524084 / 0.0004529362621637724 / 0.0008633899521319537 0.020819109086183382 / 0.029434275834813995 / 0.038030144241646684 / 0.029434275834813995 / 0.038030144241646684 / 0.029434275834813995 602 ABLIM1_2 10_114468289_G_T / 10_114613516_C_T 0.003679575880821695 / 2.068694569003633e-05 0.013324532381057309 / 0.007365229118612223 603 KCTD11_3 17_7356629_G_T / 17_7356036_T_C / 17_7353417_T_G 0.003754571069046404 / 0.00017366868689943718 / 0.0012390848435611386 0.04600482755406116 / 0.034157938547959045 / 0.0012683162409826913 604 MICALL2_5 7_1442358_T_G / 7_1448634_T_G / 7_1438692_G_A / 7_1438940_G_A / 7_1434765_T_C 0.0037969325863282813 / 0.03384278289950645 / 0.029060946696468106 / 0.029060946696468106 / 0.0032003913710269877 0.003849439864891702 / 0.00957207447144348 / 0.001706040259270731 / 0.001706040259270731 / 0.009156797658911076 605 RFC1_4 4_39304977_A_C / 4_39317086_A_G / 4_39327482_G_A / 4_39366034_T_C 0.003804607068014229 / 0.002653298567768597 / 3.2670263647126826e-05 / 0.042208647376131 0.0020300192179148733 / 0.00027426635734190813 / 0.008638827908989666 / 0.0022061266378501725 606 AP1M2_5 19_10572926_C_T / 19_10579645_C_T / 19_10587097_A_G / 19_10587125_G_T / 19_10579014_TC_T 0.0038087692058226532 / 8.991675208563765e-05 / 1.1792724900645332e-05 / 5.261102684897293e-05 / 0.001877531631940374 0.02140839327697613 / 0.010527568877864577 / 0.0015316982164778213 / 0.023908631854345174 / 0.00821632833656041 607 RPS23_2 5_82278173_C_T / 5_82278363_C_T 0.003957786808705407 / 0.0008315075457503006 7.911328672036997e-05 / 2.402875788954321e-05 608 BARX2_2 11_129436792_A_C / 11_129436677_C_T 0.004015743982394933 / 3.8908364285059496e-05 0.0011297752143511178 / 0.006988734279853065 609 LRRC1_3 6_53913863_T_G / 6_53920478_C_A / 6_53899709_T_G 0.004131339558552957 / 0.0030469251357492584 / 1.3663885062737747e-07 0.02863343366704425 / 0.016849492489466617 / 0.0009777953947081833 610 POGZ_3 1_151423306_T_C / 1_151407350_A_C / 1_151459156_T_C 0.0041738932600083895 / 8.993795886819927e-07 / 0.008612349643764727 0.020015181832936737 / 0.02909488569964382 / 0.009809035888391762 611 PRKCI_2 3_170275187_CTTT_C / 3_170263168_CAAAAA_C 0.00425052374891476 / 0.002760121279997125 0.00012798467543814748 / 0.021989752739530143 612 PGBD1_2 6_28296652_T_G / 6_28298177_A_T 0.004288328285551539 / 0.00932669296817631 0.005702673764439882 / 0.020264770709017343 613 LGALS8_3 1_236537373_GAGC_G / 1_236539197_AGTTT_A / 1_236551447_T_C 0.00435552243438307 / 0.02490692830672263 / 0.005408439057885871 0.0007287918934518675 / 0.002689054589007359 / 0.013132223069499007 614 CYP4F11_7 19_15913852_G_C / 19_15914366_C_T / 19_15924707_G_A / 19_15927524_G_A / 19_15927580_G_T / 19_15929482_A_G / 19_15929663_T_C 0.004494422448579687 / 0.004118655653677505 / 0.009014030424870815 / 0.007737694175519336 / 0.005296914283554929 / 0.006573618747648885 / 0.0045029584577228 0.01037304937937457 / 0.022954596803030098 / 0.0124267741256932 / 0.011141708950444295 / 0.011312909542474079 / 0.016341169913201302 / 0.013422572430360932 615 ZNF24_3 18_35337816_G_GA / 18_35337680_T_C / 18_35344446_G_A 0.004517003572403403 / 0.00020451573869716152 / 0.02552298264953765 0.012709161524744772 / 0.04404021168973007 / 0.008269738810110396 616 ANKS6_2 9_98796162_G_A / 9_98778486_A_C 0.0045700537784898465 / 0.009257993261520582 0.047044500480316616 / 0.03370066145919663 617 POLR2B_6 4_56995192_C_T / 4_57010789_G_A / 4_57015549_G_A / 4_57025073_G_A / 4_57005234_AT_A / 4_57023798_AT_A 0.004738473697291275 / 0.00020500907676743697 / 0.0003428363180097953 / 0.00033030198738810576 / 0.000896266309671023 / 0.010078450270635015 0.00041802227600176717 / 0.03709404459710368 / 0.03851787302536296 / 0.03254648423802934 / 0.03704331970217288 / 0.007472844031288456 618 CDC42BPB_3 14_102939620_T_G / 14_102952453_T_G / 14_102945931_T_C 0.0049774861882444345 / 0.0002680622756333545 / 0.004938189506165365 4.775637628078603e-05 / 0.003315245095495249 / 0.001918499391114136 619 WDR62_3 19_36058788_C_T / 19_36084743_G_A / 19_36094002_C_T 0.005088637492213912 / 0.016915078735087723 / 0.007443859285838674 0.0005331846126391098 / 0.000415677937125236 / 0.0005211199976091131 620 PLCB2_2 15_40298884_T_G / 15_40297623_G_A 0.005308041472208479 / 0.0013941969299030182 0.025458039339188058 / 0.04960868971387879 621 ZEB1_4 10_31461157_A_C / 10_31521191_A_C / 10_31521414_A_T / 10_31461247_AT_A 0.005342806393282525 / 0.01137703502325166 / 0.0014780611664163069 / 5.800757504246017e-05 0.013618649263675358 / 0.006377825075174489 / 0.011119739548999731 / 0.0019400920584000448 622 NDUFAF4_2 6_96891399_CA_C / 6_96896910_G_A 0.005489763925784804 / 0.0005269475943804068 0.01909002509011261 / 0.009369364198285348 623 PHIP_9 6_78947674_G_A / 6_78954723_T_C / 6_78955031_T_C / 6_78955493_T_A / 6_78969860_A_G / 6_78985312_C_T / 6_78998206_C_T / 6_79043075_T_C / 6_78947709_T_C 0.005530164992886238 / 0.00548954353554207 / 0.01455660590235654 / 1.6913729880297845e-05 / 0.0035647193470514853 / 0.005289398736036421 / 0.001837097400913216 / 0.004209432623363282 / 0.02442132743404569 0.0010048550446085317 / 0.00648756713202656 / 0.0009432749408838033 / 0.009594339103514994 / 0.0017203137452171692 / 0.0007527047164367361 / 0.006763071535609179 / 0.0016364259457283912 / 0.0006553233953188175 624 C6orf203_2 6_107044172_C_T / 6_107051038_GTTTTC_G 0.005594780806642859 / 0.010350958813062314 1.8543097341742985e-05 / 4.7416804336943046e-05 625 RIOK1_2 6_7390137_G_T / 6_7410502_GT_G 0.0056620989198510035 / 0.009940460227242327 0.004558417307934729 / 0.0007644747214841657 626 STX2_3 12_130796169_T_C / 12_130821769_C_G / 12_130827084_G_A 0.0057763908603848755 / 0.0026232291323331123 / 0.0017127068028307182 0.03019238327054641 / 0.01065610617547119 / 0.004236660791662807 627 DOCK9_6 13_98797273_A_G / 13_98888796_T_A / 13_98848509_C_T / 13_98902701_G_A / 13_98883901_TA_T / 13_98977850_C_T 0.005927598026328671 / 1.199291147137571e-06 / 0.00025790841294325934 / 0.0030628908663900517 / 0.003688722979152048 / 1.1373148571396284e-05 0.006004783016582045 / 0.01781055671478815 / 0.005840989451706359 / 0.025244747630348088 / 0.020609371467392473 / 0.01526774575825921 628 ADAM15_4 1_155056046_G_A / 1_155058081_A_C / 1_155058900_C_T / 1_155053372_T_G 0.005983172351155387 / 0.003608774130493322 / 0.02011005006826893 / 0.013070176515727179 0.02587883400458268 / 0.038829781369162535 / 0.006114928575864872 / 0.005438593481843924 629 ZNF430_3 19_21020746_C_T / 19_21033730_G_A / 19_21022725_C_T 0.006039060973644978 / 0.0017404412233575466 / 0.0032443389741318627 0.0014493947676260713 / 3.875366882434858e-05 / 7.931044376997757e-06 630 SLC41A2_2 12_104866497_A_G / 12_104805360_A_C 0.006042414055759166 / 0.003878181222682689 0.04584324420776458 / 0.01814258498012539 631 ARHGAP5_2 14_32092970_T_C / 14_32154828_T_C 0.006122997092230283 / 0.00899034241039037 0.000109609141495362 / 0.0028505632724505807 632 CTSB_5 8_11848168_C_G / 8_11853379_G_C / 8_11847933_G_T / 8_11852665_T_C / 8_11848361_G_A 0.006170091093918575 / 0.013883502523880249 / 0.013105854756963943 / 9.23481096080534e-05 / 0.0030280965583678638 0.010885538500044391 / 0.006363373856765906 / 0.00949712914495799 / 0.00465817682934427 / 0.02101769256107376 633 INTS10_7 8_19824136_G_A / 8_19825034_A_G / 8_19825081_A_G / 8_19832122_T_C / 8_19823225_T_C / 8_19823468_C_T / 8_19820404_G_A 0.006249656348718163 / 9.755626466214517e-05 / 0.0032595992956769558 / 1.3994534854585697e-05 / 0.01825573585413804 / 0.0007017951945376175 / 0.0019656324021710553 0.004251571736144285 / 0.006724158153343274 / 0.02600076241538477 / 0.015595096037435119 / 0.0063513471360198154 / 0.004329630966639476 / 0.012844960200188478 634 CHAF1A_3 19_4406163_G_A / 19_4442339_C_T / 19_4422720_A_G 0.0064074940660708 / 3.653207387854824e-06 / 1.4819698101788669e-05 0.0008752119921859383 / 2.142565869765625e-07 / 0.024620616607439628 635 MDC1_2 6_30711769_A_C / 6_30704316_T_G 0.006463206071893797 / 0.0019882207404644673 0.0020262441930086923 / 0.0013599597266763966 636 DYRK1A_3 21_37420484_TGGG_T / 21_37506256_A_C / 21_37505200_T_G 0.006470184695707864 / 0.007166152604563953 / 0.0018009306683812387 0.004141112427822946 / 0.023367448843283026 / 0.006729513952629108 637 SMPDL3B_2 1_27949055_T_G / 1_27956116_T_G 0.00686332660241626 / 0.005864140422713154 0.0015905760666496795 / 0.0137996143213625 638 EVPL_2 17_76023471_A_C / 17_76023459_T_G 0.007000637494837062 / 0.0007672223327735785 0.005291001652021031 / 0.010508474240463184 639 TOM1L1_5 17_54914767_TA_T / 17_54930294_T_G / 17_54936619_A_G / 17_54936871_A_ATTAAG / 17_54949462_TAAAAG_T 0.007038383297527345 / 0.0050109411285773646 / 0.00021710780579647815 / 0.00028231096361921765 / 0.00012667235189768908 0.04878127910267323 / 0.03275406093703293 / 0.014250045450198362 / 0.01731618533169237 / 0.009468652758198769 640 PPP6R2_6 22_50437806_T_C / 22_50444323_CT_C / 22_50438097_C_G / 22_50439767_G_A / 22_50444161_G_A / 22_50435068_C_T 0.007051784222833177 / 0.023269327181446267 / 3.439001444964778e-05 / 7.581666224780631e-05 / 3.643039740627613e-05 / 0.0008291832461198612 0.0008491344323951777 / 6.519259302157606e-08 / 0.02539141451283096 / 0.0453099522882128 / 0.048741469250829166 / 0.04553862958411738 641 DAB2IP_2 9_121772524_T_G / 9_121760326_A_C 0.0070915742180131395 / 0.007778717869708281 0.02191587566106909 / 0.01751891495836218 642 WRN_8 8_31096749_C_T / 8_31124455_G_T / 8_31141606_C_T / 8_31167122_C_T / 8_31068263_T_G / 8_31096728_GT_G / 8_31081188_G_A / 8_31154721_C_G 0.0071839350828315045 / 1.9744778112725726e-06 / 3.7195190403966525e-05 / 0.0005948019596535545 / 1.4689350346055224e-05 / 0.009117602293234885 / 4.455137121499956e-06 / 0.015467137724934844 0.015593392890488516 / 0.0002318154176456728 / 0.000309347551379363 / 0.008293074145156037 / 0.01874901447901884 / 0.0010432049093381938 / 0.02919802325158393 / 0.008229549817641594 643 SEC63_2 6_107876794_A_G / 6_107876670_C_A 0.007209006342709896 / 0.0019416198580565237 0.0015670897229372802 / 0.02957724273333363 644 MAU2_6 19_19336127_G_A / 19_19338794_G_A / 19_19338877_G_T / 19_19342712_T_G / 19_19342751_C_A / 19_19344019_G_A 0.007212671514055286 / 0.000960361991019274 / 0.0009059794395416026 / 0.0008876467494768484 / 0.0008876467494768484 / 0.001002378802893851 3.528738486135461e-07 / 1.9278481053706903e-06 / 3.174590417336852e-07 / 1.942933711490239e-07 / 1.942933711490239e-07 / 3.6691446641905493e-07 645 CDCP1_3 3_45091085_A_T / 3_45091145_T_C / 3_45095296_A_G 0.007224118191596861 / 0.003521903825993761 / 7.820303910973087e-07 0.01528693636083844 / 0.0025128061409562703 / 0.034457598045182634 646 NKTR_2 3_42630618_G_C / 3_42636885_C_A 0.007397151891706983 / 0.004629789663279317 0.0027059941965995107 / 3.766470432445502e-05 647 GSN_3 9_121321305_A_C / 9_121326911_A_C / 9_121282717_C_T 0.00754758939906495 / 9.99197364773904e-05 / 0.008701863324990747 0.0036521684936499576 / 0.014858234163842209 / 0.04144642618836994 648 MTR_3 1_236885200_A_G / 1_236897645_CT_C / 1_236812798_T_G 0.007571674596968512 / 0.00019121697493807043 / 0.006559116282295972 0.013876029031175869 / 0.019195378846888603 / 0.028819324921187783 649 DNAH1_4 3_52395506_T_G / 3_52398167_T_C / 3_52375405_A_G / 3_52394972_C_A 0.007807586400497246 / 5.188940804112937e-07 / 0.028701683809333287 / 0.04830043674512241 0.020152041638368784 / 0.04601002692990365 / 0.006840623405991567 / 0.005200470677837818 650 NDUFS7_6 19_1388539_C_T / 19_1389518_C_A / 19_1390758_C_A / 19_1391101_A_C / 19_1387920_T_G / 19_1387934_A_G 0.007902298175424828 / 0.01802139597834927 / 0.005968824663343653 / 2.816150837753928e-07 / 0.0031818920109542336 / 0.02651542479567508 0.004445598304300863 / 0.004267266689815653 / 0.007929745168935362 / 0.02277060279294577 / 0.0061684138287453226 / 0.0002841985871883526 651 TLN1_4 9_35711809_G_T / 9_35712826_G_A / 9_35700530_A_AGTTT / 9_35707057_C_T 0.008212937465719947 / 4.3027034258145176e-05 / 6.892028990051384e-06 / 1.5583116688212289e-06 0.03705209858981909 / 0.019628446580987526 / 0.03215388610263167 / 0.026823292872806558 652 PARPBP_3 12_102164766_G_C / 12_102165930_A_C / 12_102195841_T_TTAAAAA 0.008239841603573375 / 0.048432585939195916 / 0.009577111829889028 9.259289657162176e-05 / 0.0008692851756599481 / 4.1069065265654646e-06 653 FZD6_2 8_103300204_A_G / 8_103318860_G_C 0.008531191339496548 / 0.00031326302687667253 0.02679919317294273 / 0.01810032651868897 654 ITPR1_10 3_4651972_C_T / 3_4673329_A_C / 3_4712028_A_G / 3_4814550_G_A / 3_4645814_T_A / 3_4652327_G_A / 3_4653996_G_A / 3_4717319_C_T / 3_4652159_T_G / 3_4516699_C_T 0.00859416859519535 / 0.0036591352908788796 / 0.002472562485621646 / 0.0007540687837519184 / 1.174056333280529e-06 / 1.6973582056331476e-05 / 0.00018073915749960563 / 0.025102582779245618 / 0.0060202139881954326 / 0.01485572695651343 0.02221500748211688 / 0.028276024726866744 / 0.031417032356405285 / 0.020003750528966732 / 0.02165052204755015 / 0.04826424992681114 / 0.04219875731949733 / 0.00956347809995603 / 0.032544122080128725 / 0.04748127629652489 655 LAMA5_11 20_62307035_T_C / 20_62308863_T_C / 20_62315711_A_C / 20_62325178_T_C / 20_62327158_G_A / 20_62327540_T_G / 20_62310033_T_G / 20_62327738_A_C / 20_62332572_T_G / 20_62327734_623 0.008632920752406494 / 0.014295751572041776 / 0.02909024968748458 / 3.555862255130917e-08 / 2.9240346346210547e-06 / 0.00712140384613043 / 1.5666190990300454e-05 / 0.019613193736301028 / 0.03355260503997278 / 0.034148373295335904 / 1.07437734215058e 0.008839994985818419 / 0.003401604212977075 / 0.0003409731985327621 / 0.010970601799299722 / 0.037454561614064526 / 0.04839717926265442 / 0.00011553533752570969 / 0.00016041497097470358 / 0.00634985461358608 / 0.00014957483336764524 / 0.02125937044218393 656 MAPRE2_2 18_35132001_G_GT / 18_35070377_A_G 0.008697538540744818 / 0.0008936827603968188 0.027950082818089944 / 0.013874344261478143 657 PCM1_14 8_17938873_A_G / 8_17938874_C_T / 8_17947156_G_A / 8_17957171_G_C / 8_17962063_C_T / 8_17962252_A_G / 8_17972247_C_CAA / 8_17993739_C_A / 8_18010736_C_A / 8_180_180A_C8A_C8A 0.008797381653836422 / 0.008797381653836422 / 8.592105380343799e-09 / 9.956680768337928e-13 / 6.195811157969624e-08 / 1.8937727055349602e-07 / 0.012906783621554044 / 0.00024859599240286334 / 0.0005752822575338514 / 1.5559989504674227-e 0.013270249004941498 0.0286880097933444 / 0.0286880097933444 / 0.005755604603604279 / 0.003664181277087841 / 0.003941798080137453 / 0.000146676782393952 / 0.003377252281952908 / 0.0004892784845984415 / 0.01725609483145887 / 0.00016889400218637822 / 0.0005696202104790463 / 5.94669308647235 658 LAMC2_2 1_183207851_G_T / 1_183207864_G_T 0.0090311817049441 / 0.0010913836051824374 0.02500420336879176 / 0.034260068788679536 659 FAT1_2 4_186706505_TAAAAAA_T / 4_186628213_A_C 0.009108698459398929 / 0.008101657943453211 0.02585265305545377 / 0.01860566173117391 660 SQSTM1_3 5_179833009_G_A / 5_179822433_T_C / 5_179832842_G_C 0.0096926694417795 / 0.004856219591816439 / 0.0277352874184494 0.03979973429187952 / 0.0024949336391905503 / 0.0024314650981475784 661 CCDC25_3 8_27736133_T_C / 8_27740525_GA_G / 8_27740655_A_G 0.009721303652590912 / 0.0012870249285031976 / 0.019736174159448082 0.012214514779241077 / 3.013644227200994e-08 / 0.009242113446549792 662 PTGFRN_2 1_116949272_C_G / 1_116985006_T_C 0.009786238032301352 / 0.0007152254747991232 0.04386987327886 / 0.015007302908998025 663 CUEDC1_2 17_57872703_C_T / 17_57873465_G_A 0.010263213673294223 / 0.0029406902030506186 0.0013582824059236026 / 0.00965828204249475 664 POLR3D_5 8_22247989_T_C / 8_22247116_G_A / 8_22247770_T_C / 8_22250473_A_G / 8_22245170_T_G 0.010361813952662016 / 0.040760845043798406 / 0.010265363996485286 / 0.010265363996485286 / 0.03202227743017228 0.0015081231813274575 / 0.0005996811951877831 / 0.0014851724380103976 / 0.0014851724380103976 / 0.0034846025589736784 665 MDN1_10 6_89661483_G_A / 6_89662267_C_T / 6_89680724_C_A / 6_89712908_G_C / 6_89728912_G_T / 6_89745710_T_C / 6_89819438_A_G / 6_89819440_C_G / 6_89819446_A_G / 6_89656810T 0.011142557737209857 / 0.019733545814518076 / 0.00671054318104286 / 0.009319633314546674 / 0.029067614736169964 / 0.014718502010945343 / 0.03726926768860217 / 4.658109373380921e-05 / 0.00043794075690144836 / 0.001077236984005633 8.702195141061847e-05 / 4.241840867716095e-05 / 3.792323014139115e-05 / 0.002381685713249437 / 0.003051989681616468 / 0.0024784505977437274 / 0.002315253787970113 / 0.00030565312846269634 / 0.0005358395597195241 / 0.045388379703494304 666 ZNF407_5 18_74635526_T_C / 18_74881076_C_G / 18_74881080_A_C / 18_75064165_G_A / 18_74881141_G_A 0.01132130975657727 / 0.03691411059827635 / 0.002564188916256107 / 0.00027018930993972406 / 0.0024107982547803396 0.0030145474545959137 / 0.009890224680183182 / 0.03975077518004473 / 0.0037574487440396095 / 0.018926593122392126 667 C18orf21_2 18_35977490_T_C / 18_35973023_A_G 0.011570265284110644 / 0.04350573719131977 8.814319140246499e-05 / 0.009001638536085271 668 DNHD1_2 11_6566998_G_A / 11_6502909_T_C 0.01157615377505105 / 0.024706472106323003 0.003441011845932656 / 0.0051368432267910715 669 KCNQ5_2 6_72622312_C_G / 6_73194868_A_C 0.011667048329227513 / 0.008556892857902195 0.005821769162034106 / 0.002035847347947271 670 USP7_3 16_8916969_T_TA / 16_8921401_T_C / 16_8919178_A_G 0.011921515809972538 / 0.0007259106255980508 / 0.00985787434616614 0.007935686984078177 / 0.03489258945527392 / 0.01271404693174776 671 KRT19_2 17_41524128_T_G / 17_41524420_C_T 0.012145831162385651 / 0.02329208372328466 0.006794604788851329 / 0.0075159453943370955 672 CHD4_2 12_6598281_A_C / 12_6596093_T_C 0.0122076861217219 / 0.004382346617449564 0.0023450404288739924 / 0.005341196474657028 673 TRIO_5 5_14270972_A_C / 5_14380924_T_A / 5_14287139_AT_A / 5_14485052_GTTTT_G / 5_14304660_GA_G 0.01228372579415868 / 3.324291735916414e-05 / 0.01866091088461598 / 0.0021188750196952637 / 0.001000539371629746 0.0041763005884629285 / 0.009266068007448034 / 4.1269944199248776e-05 / 0.00011802420018250479 / 0.0066869864395857175 674 NR2F6_3 19_17232488_A_G / 19_17240807_T_C / 19_17240813_T_C 0.012426826069594731 / 0.008405600723765323 / 0.0104569397340928 0.0005711072972571918 / 0.006907234943082266 / 1.728226736131038e-05 675 HNRNPH1_2 5_179621204_T_C / 5_179614784_GAAAAA_G 0.012466319116509934 / 0.03611121611218025 0.0008981889773064157 / 0.009729395921872941 676 POLDIP3_2 22_42585672_T_C / 22_42585502_A_C 0.012811765150489051 / 0.04394982419601543 3.6252104008481515e-06 / 0.004353728585767742 677 CASKIN2_4 17_75501358_G_A / 17_75501713_T_C / 17_75503616_T_C / 17_75508335_T_C 0.01313679969802845 / 0.0005650477736965628 / 0.0014275310574789414 / 0.004128633364054907 0.002427426610400476 / 0.00023272703416067725 / 0.00689117538932749 / 0.024705224854909082 678 ZNF557_3 19_7083618_A_G / 19_7083750_A_G / 19_7074861_G_A 0.014332802500416091 / 0.016198364111666076 / 0.009991664044269358 1.6329734686551152e-07 / 4.640996358288638e-07 / 0.019872633283012617 679 BPTF_2 17_67825365_C_T / 17_67911547_C_G 0.01437455334956587 / 0.027807620738219758 2.5754103071800682e-05 / 0.006958200054189394 680 UGGT2_3 13_95833163_A_G / 13_95853698_T_C / 13_95860933_T_C 0.015116310313098947 / 0.037400522782126695 / 0.007496186466991611 0.000224596103770692 / 0.0011686091908779301 / 0.002068524896740717 681 FNDC3B_3 3_172362611_AT_A / 3_172328905_GT_G / 3_172286041_CTTTT_C 0.015509630370521969 / 0.002266663581871069 / 0.0003779941256659541 0.0007669696976411361 / 1.7757436099968484e-05 / 0.031871180713847265 682 CLIP1_3 12_122328152_A_C / 12_122328157_C_T / 12_122328162_C_T 0.01554438347868009 / 0.004768276278894758 / 0.002667521200669866 0.002481037749459045 / 0.041472618812521435 / 0.048511002649469816 683 TNKS_6 8_9680125_G_A / 8_9720284_A_AT / 8_9720294_C_A / 8_9735571_A_C / 8_9751720_A_C / 8_9766458_A_C 0.015553063070783985 / 0.021640953132470588 / 0.009525586921605824 / 0.006640140033620625 / 0.006977786341777385 / 0.032727629530903864 1.1196019412041484e-09 / 6.428366457977679e-07 / 9.234432766615335e-08 / 4.809045747636942e-06 / 0.019396751254115357 / 9.650265166072016e-07 684 NAA15_2 4_139349721_G_A / 4_139349435_AT_A 0.01573160679440035 / 0.003429044586968857 0.0002098904518747522 / 0.002911064627846368 685 RANBP3_5 19_5928023_T_G / 19_5928174_T_C / 19_5915583_A_G / 19_5925847_A_C / 19_5978199_C_T 0.01583040778996785 / 4.474815722770587e-05 / 5.7769976083466666e-05 / 0.0026896515436457035 / 0.007526230369901563 0.009045897483820205 / 0.0004179910655369823 / 0.03657225828634877 / 0.013386174688145538 / 0.043887995871297616 686 CCP110_6 16_19536035_A_G / 16_19536181_C_T / 16_19545945_C_T / 16_19541861_T_C / 16_19536052_C_A / 16_19548016_T_G 0.016159655378318708 / 0.04502177918333454 / 0.008022125809200288 / 4.851993209582035e-06 / 0.0004153878057481152 / 0.025513237898367132 0.00016378049017362915 / 0.0005567133937571787 / 0.0006179187799490345 / 0.015929257083152543 / 0.0007996357401027085 / 0.009536820248258198 687 ANXA11_2 10_80166029_C_T / 10_80161797_T_C 0.016605419991514502 / 0.0051164435438795204 0.007800123858178394 / 0.0013053025194313356 688 PLEC_5 8_143935900_T_G / 8_143916360_A_G / 8_143918739_A_C / 8_143929244_A_C / 8_143934289_T_G 0.01665471808934805 / 0.0034243187807631525 / 0.0018067465091272969 / 0.0008521926558447601 / 0.0001319263889148404 0.0004960012901022363 / 0.00910116635228719 / 2.138708286444241e-05 / 0.04249632659180479 / 0.008202162742211878 689 PDHB_5 3_58429863_C_A / 3_58427942_G_T / 3_58430808_C_T / 3_58431043_T_TTTA / 3_58431689_C_T 0.016694590509161198 / 0.0034915452482365546 / 0.0014468501934601355 / 0.00012132584593612988 / 0.0014468501934601355 1.9636106867401007e-06 / 9.607912469556515e-06 / 1.1215690852590127e-06 / 4.480434017438887e-06 / 1.1215690852590127e-06 690 ABHD12_3 20_25307869_C_T / 20_25297964_G_A / 20_25301097_T_C 0.017594886478281925 / 0.043687457267011516 / 0.004129132243776882 8.56668297363822e-06 / 0.00227969505884927 / 0.0004270759204191932 691 TRAPPC8_10 18_31858057_A_C / 18_31913653_A_G / 18_31900873_G_A / 18_31900876_C_A / 18_31867505_T_G / 18_31907633_T_A / 18_31846589_A_C / 18_31871211_T_A / 18_31901115_GT_G / 18_31858058 0.01811627325789324 / 0.0017149077087971164 / 0.007882909715425471 / 0.0003097530865800165 / 0.0017696529343949547 / 0.003408008625421304 / 0.0025767772792916893 / 0.020052128513604172 / 0.0014872998913138286 / 0.009626844127190594 0.006180390175955454 / 0.009898646981541573 / 3.5402082656175115e-05 / 2.004341589623153e-05 / 0.00036773660587014015 / 0.0008596942505949141 / 0.0019258630221215085 / 0.0005317253240119541 / 0.03754796616685669 / 0.003048367023556882 692 NARF_2 17_82488071_A_G / 17_82485433_G_A 0.018611831902577654 / 0.0032741374426950077 0.0015678226483248074 / 0.03776328708562675 693 RPL9_3 4_39454772_G_A / 4_39458104_T_C / 4_39457622_A_G 0.01872028096022281 / 0.038040018913816906 / 0.013766563241610607 0.004161577416808298 / 0.004570198384291764 / 4.793806278603332e-07 694 SENP7_2 3_101347873_T_A / 3_101513249_C_A 0.01892010828896953 / 0.027162288974149237 4.432034386075619e-05 / 0.00843965290168897 695 HERC1_4 15_63666001_A_C / 15_63666004_T_C / 15_63754569_A_C / 15_63706823_T_C 0.018947416114520832 / 0.012801946597404643 / 0.009094911651776984 / 0.0001905333488051304 0.0009552551098417773 / 0.0050390069990103115 / 0.007343118479360836 / 0.005050957906342418 696 DOCK11_2 X_118627539_A_C / X_118580020_T_G 0.019238892996198773 / 0.002446966159681028 0.00012436903410890539 / 0.02379391735060052 697 KLF5_3 13_73063987_G_T / 13_73062772_A_AGTGT / 13_73063986_TG_T 0.019354403860496208 / 0.037567154465037694 / 0.006314572274949971 0.008502737493358522 / 0.0008455054702052634 / 0.045197394376435635 698 FERMT1_2 20_6119441_A_G / 20_6076305_T_G 0.01953104506649206 / 1.5328575507414378e-05 0.003951008923557318 / 0.005589077504505465 699 CGGBP1_2 3_88056114_A_C / 3_88058700_T_G 0.019690640293771062 / 0.0001488078729312028 0.0013325718879930134 / 7.124415972693971e-06 700 CEP85L_4 6_118511157_T_C / 6_118565452_T_C / 6_118565798_G_T / 6_118652790_A_G 0.019951442705337254 / 3.4006295145334306e-05 / 0.006640489210238536 / 0.005690521125333515 0.0019936945989450267 / 0.031500707148776626 / 0.011376444437361329 / 0.01248838915032558 701 TCF4_7 18_55585157_G_A / 18_55464257_C_A / 18_55463971_TGTGTGTGA_T / 18_55275657_A_G / 18_55403517_A_C / 18_55461237_G_T / 18_55234488_T_G 0.02005132938992895 / 9.139603483849228e-07 / 0.003907248287482544 / 0.04979553061082194 / 0.027277557605803925 / 0.004036463102105114 / 0.0005592100190603741 0.002362550141751555 / 0.032420073593804284 / 0.03333184670009802 / 0.0013930308437610063 / 1.5397131093463103e-06 / 0.04572000946513434 / 0.005926553123167896 702 DQX1_2 2_74518953_C_T / 2_74519195_A_T 0.02016550460713128 / 0.02345411840768387 0.001543466936969916 / 0.0012259823356569838 703 UBR5_3 8_102327653_A_C / 8_102288240_T_C / 8_102311353_A_G 0.02158342295983112 / 0.000182245886028422 / 0.002891650419980013 0.0014448817758050778 / 0.041616237854309936 / 0.00926532742682097 704 UBR7_2 14_93227076_C_T / 14_93227060_C_A 0.021764228343538142 / 0.00036547494521639036 5.580051554471299e-12 / 0.004489348973894868 705 PRDM15_6 21_41804523_A_G / 21_41857170_C_CT / 21_41878737_C_T / 21_41878845_C_CG / 21_41879218_C_A / 21_41860296_C_G 0.022209828018085867 / 0.0016831430872538335 / 0.001963497325920565 / 4.181886700329235e-07 / 0.0008539747138144563 / 0.003762939149636617 0.0024789131706555692 / 0.04559041805735448 / 0.004333100546220035 / 0.0014981405701937028 / 0.007033127481264185 / 0.003918924565748825 706 HPS4_3 22_26464303_G_C / 22_26466187_C_A / 22_26466246_T_C 0.023338960947810374 / 0.0034082024391394804 / 0.008599880725164986 0.00049975228288003 / 0.013660798942983977 / 0.013660798942983977 707 KIF13A_2 6_17759921_G_T / 6_17779691_GA_G 0.02351576585497226 / 0.0016700241845674759 0.005082432403932738 / 0.03874282920193672 708 SLC35B4_8 7_134294793_A_T / 7_134294800_C_T / 7_134294826_A_G / 7_134295043_T_C / 7_134296475_G_A / 7_134299375_A_G / 7_134300126_G_A / 7_134304791_A_G 0.02373113198705864 / 0.01698627709999008 / 0.006372984518535906 / 0.02196618128109366 / 0.0003440877501955943 / 0.006567115319239084 / 3.4006295145334306e-05 / 0.005046500727253695 0.007700956159853255 / 0.0033988992551489622 / 0.003846947305778054 / 0.003846947305778054 / 0.0005322435434420271 / 0.004732359355015072 / 0.00026123770283039777 / 0.0007109966209961128 709 L3MBTL2_6 22_41213686_C_T / 22_41221314_G_C / 22_41217184_C_T / 22_41217299_C_T / 22_41221156_T_TG / 22_41214238_A_G 0.02384699817673188 / 0.036506965435244586 / 0.00046243520821700383 / 0.0014542660494230402 / 0.0048712846790899276 / 0.009223190722677185 0.0010787186334203051 / 0.0001832674707524145 / 0.0038205423576211455 / 0.004209694792725524 / 4.2157738222413464e-06 / 0.04965109007915304 710 RAI14_6 5_34810866_G_A / 5_34811689_T_C / 5_34812303_A_G / 5_34812384_A_G / 5_34814795_A_G / 5_34826376_A_C 0.02398248389974741 / 0.003021738485801497 / 0.03016889098915158 / 0.04699754955019005 / 0.007276272312251042 / 0.03015590631046501 0.005930385895234786 / 0.02067007422009637 / 0.008963944637711066 / 0.0075054618188784596 / 0.002646842318515723 / 0.006485048570616563 711 ARHGEF10L_2 1_17632421_T_G / 1_17581112_C_T 0.02441616386812752 / 0.008405600723765323 0.00740919250255517 / 0.019746113249432044 712 WFS1_2 4_6300580_T_G / 4_6301666_T_G 0.024665242803626187 / 0.008957131401361508 0.0005139212842413073 / 0.005931412638336574 713 TPP2_5 13_102645085_CT_C / 13_102649187_G_T / 13_102629949_C_G / 13_102634223_C_T / 13_102645085_CTT_C 0.024741402723073853 / 0.028415295283801194 / 0.001061432461116305 / 0.03296472481201721 / 0.00032041277623460525 0.0017617933204615989 / 0.0003388682906380855 / 2.491492385425685e-05 / 0.0010859815068279958 / 0.04128722708381896 714 DPY19L3_3 19_32480317_C_T / 19_32482171_C_T / 19_32457979_A_AT 0.02575962131883935 / 0.041529928834727996 / 8.068330723796263e-08 0.00488668851811109 / 0.00656763144792808 / 0.0003669711749463792 715 SYNE1_13 6_152149487_A_G / 6_152310394_A_C / 6_152302141_A_G / 6_152350340_A_C / 6_152350418_A_G / 6_152350784_G_GA / 6_152350840_A_G / 6_152354719_A_G / 6_152373049_T_C / 6_152_C 6_152G_ 0.02589202251594358 / 0.0068225672761204 / 0.018111885168250186 / 0.001534088782688901 / 0.00015349542079229654 / 0.003947934300958396 / 0.009039115199453142 / 0.0032281218393380826 / 0.034085027891066176 / 0.0074217808535962425 / 0.0003084243419514754 / 0.04013949092531816942 0.0022312687521415984 / 0.000300569048618415 / 0.000916091757381376 / 0.04334315784101184 / 0.025133645776259043 / 0.015037738599618973 / 0.049886685026608805 / 0.04777964311542563 / 0.003302156741579197 / 0.012499408296212235 / 0.002950466518563372949 / 0.0028434342 716 BAIAP2L1_2 7_98312162_T_G / 7_98310492_T_G 0.02645273506751201 / 0.017881464475754172 0.002108350377110309 / 3.1631490207583316e-05 717 CXXC1_4 18_50283881_C_G / 18_50283981_A_G / 18_50282775_A_C / 18_50285505_A_G 0.02700492420991353 / 0.00030830634455756233 / 0.00020363998830215009 / 0.024668590953954232 0.0054045514118498715 / 0.0069760254674185035 / 0.00041677651706905364 / 1.2396826716404366e-06 718 ITGB5_3 3_124769064_T_G / 3_124796789_C_T / 3_124809087_T_G 0.027271474201973192 / 0.0030628908663900517 / 0.02459057498205289 0.0006588536356118503 / 0.03655295537599197 / 5.4585187494895796e-05 719 BRD4_2 19_15255220_T_G / 19_15264730_T_G 0.02738257500091704 / 0.0024688743871748233 0.003128882089479218 / 0.012931811845921107 720 TUBGCP6_3 22_50218683_C_T / 22_50226183_A_G / 22_50216669_A_G 0.02873848846989375 / 1.7193787546395546e-05 / 0.001425645880342349 0.0032493001194240914 / 0.004608803965780261 / 0.0053976890998902035 721 SH2D4A_2 8_19373444_G_GTA / 8_19373444_G_A 0.029078590360841292 / 0.0012205889084294006 0.0029847738366696104 / 0.03439931765423256 722 UPP1_3 7_48088999_G_A / 7_48108129_C_G / 7_48108147_T_G 0.029144965782620207 / 0.015833254501378846 / 0.01682115524692246 0.0003765748447247093 / 0.0002337913556195707 / 0.0015081620173450355 723 WDR48_5 3_39068755_C_T / 3_39069649_C_A / 3_39066494_T_A / 3_39077046_G_A / 3_39052175_T_A 0.030420442989910295 / 0.044145461001922535 / 5.492585713676155e-05 / 0.00014207366024108895 / 0.015418219237359813 0.00013091692663621323 / 1.1291180538837308e-09 / 0.030704581537927867 / 0.04365312343408456 / 0.002516254064872987 724 PDS5B_5 13_32741072_A_T / 13_32758091_C_T / 13_32675925_C_A / 13_32710010_G_T / 13_32652145_GT_G 0.030726392282429425 / 0.00123879071402958 / 0.0006856670147522433 / 0.002121608222392312 / 0.0007921211551638221 0.001639201016530517 / 0.0023301391981286807 / 0.004241708828197667 / 0.017388913859398773 / 0.002787725341881676 725 AHNAK2_13 14_104948863_G_C / 14_104950348_C_G / 14_104952007_T_G / 14_104952054_C_T / 14_104954590_A_G / 14_104955559_A_C / 14_104949306_T_C / 14_104950948_C_T / 14_104946565_A_C / 14_104_104_104G_14_10494 0.0308328381135858 / 0.016748316074642184 / 0.03839823545317707 / 0.03874915731384604 / 0.0072096008154851265 / 1.5768275144985015e-05 / 0.006402387188591212 / 0.006209224175079767 / 0.02197650841839336 / 0.005813098445302893 / 0.024214266407806717 / 0.0185888935 0.0037872773041585602 / 0.0010008042001551844 / 4.242877237542688e-05 / 4.758634079373864e-05 / 0.044213954062984784 / 0.00506490504122054 / 0.005256944789299486 / 0.009057439080581924 / 0.006657596405885244 / 0.015474300784924832 / 0.00350031652733231949 726 PSIP1_4 9_15469426_TA_T / 9_15472613_GA_G / 9_15478664_T_C / 9_15473904_C_CA 0.03090002089985741 / 0.010885733995064931 / 0.0036412739882121493 / 0.019522544533840024 0.0021167351616768765 / 0.002781333210996778 / 0.04454350703768868 / 0.047598542315053116 727 ANK3_2 10_60140286_C_G / 10_60140292_G_T 0.031415751059474716 / 0.004915637551152243 0.006334167714527676 / 0.025015110862319518 728 PLEK_3 2_68380987_A_C / 2_68388306_A_G / 2_68380161_C_G 0.0317726416239668 / 0.008640427676032429 / 0.003025481684231003 0.0018651167043750433 / 0.012112306050675708 / 0.004442991541746456 729 HMGB1_2 13_30463652_C_G / 13_30465849_T_C 0.03226480417721332 / 0.0001648093940653516 0.0005823170484383475 / 1.5385023502599213e-07 730 ACTN1_2 14_68890121_A_G / 14_68904620_A_G 0.032894585296185316 / 0.002540635063275344 0.0030504600602986385 / 0.01924890787722053 731 FAM193A_2 4_2662705_A_G / 4_2659865_A_C 0.033419216681695084 / 0.04113816735227994 0.006119225115333783 / 0.002421422710409682 732 ALS2CL_3 3_46688267_C_G / 3_46671861_C_A / 3_46683906_C_A 0.03379224538431711 / 2.315014453759593e-05 / 0.005940717099935289 0.0010458636942191153 / 0.016517080453509674 / 0.048512125386189216 733 SMARCA5_3 4_143521582_C_T / 4_143514027_G_A / 4_143513907_T_G 0.03389913212461259 / 0.0005336701932334038 / 0.00047650766195259835 0.009752627346239709 / 0.0006586181076668231 / 0.004556295949163353 734 TMBIM1_4 2_218278506_G_A / 2_218278604_T_C / 2_218279426_G_A / 2_218282145_T_C 0.03396031249525595 / 0.02844679337110864 / 0.0068961961974542295 / 0.0018492744109954121 0.002273449490648745 / 0.0012042001777173455 / 0.0022480783740468167 / 0.030530266212098117 735 ZNF236_5 18_76959812_T_C / 18_76968158_T_C / 18_76968252_C_T / 18_76936580_G_T / 18_76968514_A_G 0.034863364756142684 / 0.00544264119615534 / 0.007385442293655849 / 1.258127500782992e-05 / 0.001396157570840323 0.004671655781344212 / 3.359123080186937e-06 / 3.816383122507129e-05 / 2.2508576141383803e-05 / 0.00014020410621502926 736 DMAP1_3 1_44213884_A_G / 1_44219323_T_C / 1_44214487_A_C 0.03508585380179657 / 0.0001543183975019544 / 0.000996146741984629 2.797176359518221e-05 / 0.04898236049763705 / 0.041077293102317024 737 GIT2_2 12_109951210_A_C / 12_109952676_A_C 0.038020170939281527 / 0.044654978525331915 0.0015711134341594402 / 0.0073535263645836966 738 PBRM1_4 3_52642049_CA_C / 3_52642048_AC_A / 3_52642050_A_T / 3_52658412_CTT_C 0.03826328245790342 / 0.003417708183485354 / 0.003417708183485354 / 0.004371631368875628 0.0014123627803440367 / 0.00010786476378721626 / 0.00010786476378721626 / 0.04797045127180218 739 SEMA4B_3 15_90230550_C_T / 15_90219735_T_G / 15_90223369_T_C 0.0382907038385724 / 0.00014017436078508742 / 0.003606528003523896 0.003576989974401659 / 0.0196110620734337 / 0.012423711849739305 740 CDH1_2 16_68823310_T_G / 16_68810107_C_G 0.03866739925480673 / 2.3568872507011226e-05 0.0025541666878341144 / 0.0045199561560194616 741 PAK4_3 19_39176740_T_C / 19_39178411_T_C / 19_39178960_A_ATG 0.03964657176847531 / 0.0031968419187330646 / 0.00031366512220605466 0.0005253339462112416 / 0.012050619287225093 / 0.04112372072532399 742 KDM5A_2 12_310904_G_A / 12_323658_C_A 0.040083104628847975 / 0.03485434053230182 8.99232571405919e-08 / 4.775460326696479e-06 743 CHMP7_4 8_23249152_A_G / 8_23260130_T_C / 8_23260642_T_C / 8_23255149_C_T 0.040858161657175214 / 0.0021955959993491484 / 0.001347026932454516 / 0.005979199546716722 0.00985156252549634 / 0.007951126415472621 / 0.005852678740537498 / 2.528028640474925e-05 744 FASTKD1_2 2_169557305_CA_C / 2_169557305_CAA_C 0.04142328785089491 / 0.016746895905411573 0.00016945881737810868 / 0.003864236188058555 745 MRPL39_5 21_25587877_T_G / 21_25588774_T_C / 21_25594005_A_G / 21_25603938_A_G / 21_25607316_G_A 0.04194490101459973 / 0.01937493996228174 / 0.01845646940649424 / 0.02800309093409305 / 0.00630118834188515 5.7418126731545284e-08 / 3.6929628125728576e-08 / 2.5701269842959545e-08 / 1.0577675519010665e-08 / 3.688861166466308e-08 746 PON2_2 7_95406313_A_C / 7_95406317_T_C 0.04295809677939748 / 0.03518057074232925 9.367508145310504e-06 / 9.041805671182428e-07 747 ATP9A_2 20_51608625_A_C / 20_51627544_T_G 0.0453107586125816 / 0.0033064577154371753 0.0016205979394364285 / 0.046011362965187 748 SYNE2_3 14_64189964_AT_A / 14_64022731_CT_C / 14_64122119_G_A 0.04554515566635235 / 0.0259958042872378 / 0.005029743152006167 6.34029580306576e-05 / 0.003556496243260812 / 0.031891035954103614 749 EXD2_2 14_69236592_C_T / 14_69236597_G_T 0.045815872520569866 / 0.007261223228798206 0.006743325380355538 / 0.009984452523516405 750 USP22_9 17_21002832_G_C / 17_21002938_C_T / 17_21002944_A_G / 17_21005012_T_C / 17_21018179_C_T / 17_21021210_G_A / 17_21021307_T_C / 17_21028347_G_T / 17_21043080_T_C 0.04602479247359704 / 0.008276359973551 / 0.0003145539245206166 / 0.00013159988064048868 / 0.00017641068386537028 / 0.00018037842009303046 / 0.002766843921558569 / 0.00965100020152009 / 0.0021915580128042123 5.2405530742318296e-05 / 0.0001522332352001979 / 0.0010200867803667195 / 0.0002608036035294038 / 0.0002258154609608441 / 0.00012857609143244398 / 4.777859944106238e-06 / 0.001140393407840919 / 0.01642994041963463 751 R3HDM1_2 2_135621624_GT_G / 2_135661361_A_C 0.04643229751040803 / 0.01096218490346052 0.007933574405897037 / 0.00075038338644858 752 LAIR1_2 19_54364274_T_C / 19_54364717_T_C 0.04672350230262375 / 0.015465209925053043 0.008257714587898193 / 0.006617848488520711 753 EVL_5 14_100126634_T_G / 14_100132827_G_A / 14_100126622_G_A / 14_100132645_T_G / 14_100135917_A_C 0.047372429474904484 / 0.0016660544745078804 / 0.004134369004838065 / 0.00016640135361204822 / 0.0031029134247096963 4.756430435799507e-06 / 0.00563219201718044 / 0.01997007957497231 / 0.026704266687616097 / 0.006469582595095918 754 RNF123_2 3_49714152_C_T / 3_49700145_G_T 0.047756940070976237 / 1.1366734297895966e-06 0.00816572334990732 / 0.0037608177292696564 755 DNMT1_2 19_10162649_G_A / 19_10143809_G_C 0.04804143143713783 / 0.022663915935835485 0.0013474327860987167 / 0.0054179883970128856 756 BTBD16_4 10_122275013_G_T / 10_122275188_T_C / 10_122285973_C_T / 10_122291060_G_A 0.04876523124872777 / 0.04476796806488366 / 0.00874169822078938 / 0.03049550442980961 0.0003520007001970831 / 0.00020893956494733148 / 0.0013169765604353282 / 0.0026073441109972398 757 FUCA2_2 6_143504166_C_A / 6_143507227_A_G 0.049200639651661375 / 0.029895339238934462 0.00639339868461808 / 0.0054745403112583324 758 PPIP5K2_3 5_103201499_T_G / 5_103201584_A_G / 5_103201656_T_C 0.04957254295359858 / 0.00015517194478671765 / 9.016600091479696e-05 0.00015030812167049831 / 0.020151832289907558 / 0.029631285544831236 759 TIMM44_3 19_7932571_A_G / 19_7932574_T_G / 19_7932577_T_G 1.3167297251695571e-05 / 0.0003422957438462025 / 0.0005904858316322034 0.02845639919448445 / 0.006688970144575634 / 0.006057634937627619 760 MEX3C_2 18_51196847_C_T / 18_51196775_CGCCGCCGCG_C 1.329885109524148e-10 / 0.0022225090338153708 5.249784413332885e-07 / 0.01963887463995091 761 MTUS1_3 8_17754377_G_A / 8_17755366_A_G / 8_17721812_A_C 1.3576985363683765e-05 / 1.972258766974004e-08 / 0.02629101974751153 0.001701316781434502 / 0.026616233857667596 / 0.002181030051469235 762 CTSH_2 15_78922969_A_C / 15_78939184_A_AG 1.4037598311677378e-05 / 0.0001924278188105154 0.010345021977573308 / 0.0344244477250216 763 IL18_3 11_112150193_T_G / 11_112155193_G_C / 11_112155192_T_C 1.461260124702572e-05 / 7.96641505141555e-07 / 0.03134154150698633 0.012472744364369587 / 0.011978242096605442 / 0.007248539214372238 764 ZNF654_2 3_88139270_G_A / 3_88140191_T_C 1.4751691487034687e-06 / 2.0819038805248358e-07 0.0018019171147236148 / 0.0019048877551503765 765 ZNF589_6 3_48241161_TGCGC_T / 3_48241205_A_G / 3_48257949_T_C / 3_48268338_C_G / 3_48286239_T_C / 3_48286261_G_A 1.6889590876869102e-06 / 1.1715920482680521e-06 / 7.920379942105592e-05 / 2.8491798121821795e-05 / 1.5027613326502343e-05 / 7.796162715352446e-06 0.0007986098597650371 / 0.0010457901523321454 / 4.006095509659407e-05 / 0.0020191705610664206 / 0.001627877596998014 / 0.0011919391649323414 766 EPS15_6 1_51361249_T_C / 1_51405766_G_GACTC / 1_51440277_CTGTG_C / 1_51463832_TA_T / 1_51472751_T_G / 1_51461237_G_A 1.6925862398730225e-06 / 4.1443509369940415e-05 / 0.031894015484001656 / 3.0950467922083264e-06 / 0.02951071302033457 / 0.01032478965873057 0.0002615744055786565 / 0.0005725418098281438 / 0.00017362501014406024 / 0.0002615744055786565 / 0.0045422702652321255 / 0.0029577065864897127 767 ZNF266_2 19_9413509_A_G / 19_9420011_TG_T 1.7177250175637761e-06 / 0.04040969628183889 2.6110373221371133e-14 / 0.004948136499581445 768 BCAM_2 19_44820881_G_A / 19_44811510_C_T 1.7938533698319987e-05 / 0.0006276370995178965 0.006588412083819078 / 0.021875016141096045 769 C3orf38_3 3_88150029_T_C / 3_88150035_T_TC / 3_88150148_T_C 1.7996666116084316e-06 / 0.00014178936922186315 / 2.595905755446793e-06 6.57647003118834e-05 / 4.649030455483649e-05 / 7.105213671060247e-05 770 ERICH1_8 8_659132_C_G / 8_657766_C_G / 8_658018_C_T / 8_666590_T_A / 8_673593_G_A / 8_715858_C_T / 8_659879_A_C / 8_659039_G_A 1.8121573621263876e-05 / 0.0010420319235614432 / 0.04660176454698252 / 0.004834244365989843 / 0.007260620745344446 / 0.04859602375702362 / 0.0025352106440479803 / 0.002455544576447661 0.0054140514901705895 / 0.043640948824396286 / 0.0013028832620993098 / 0.018154111038570942 / 0.01865482112843118 / 0.00034437810537597347 / 0.0461414202945825 / 0.014420687330437538 771 LSR_2 19_35267372_G_GGGA / 19_35267177_A_C 1.823380047726112e-06 / 0.03651632235421607 0.0021105674130373147 / 0.0028831204631532326 772 PIK3C3_3 18_41955191_C_G / 18_41955194_A_G / 18_42043978_A_G 1.9440372522869497e-06 / 0.0006320335833085862 / 0.023735103370508225 1.065744821934887e-06 / 0.0001342557450694381 / 0.00031280032152652704 773 TAF3_4 10_7824594_T_C / 10_8013652_G_C / 10_8013913_G_A / 10_8014532_C_T 2.0664435570944493e-05 / 0.004655883072306037 / 0.00943383216960874 / 0.0009463104379838767 0.03748233778862958 / 0.008249411816346357 / 0.004857051949006447 / 0.0014732747867095904 774 FNBP1_2 9_129909080_T_TG / 9_129923982_A_G 2.1184979283245958e-05 / 5.268485267589101e-05 0.013989753243576588 / 0.019443664939858312 775 SACM1L_14 3_45719623_G_C / 3_45722143_A_G / 3_45722754_A_G / 3_45723052_T_C / 3_45731250_T_C / 3_45731280_G_A / 3_45732240_G_A / 3_45737644_A_T / 3_45705344_A_G / 3_45__A_G_3_45_45 2.2026676208492585e-06 / 9.443816831049491e-07 / 0.0022018800476893614 / 3.5837125763699036e-08 / 4.4397997289151143e-07 / 1.2227532248856571e-06 / 1.3468374724431254e-06 / 7.150800554712763e-07 / 0.013551678428059705 / 0.00535 899 2.7990310927885382e-05 / 2.6591646486392756e-05 / 0.006779520290921261 / 3.962907852818685e-05 / 1.1237814806460453e-05 / 4.359294069545172e-05 / 5.1558332133000766e-05 / 3.496973226569382e-05 / 0.0006684767742569695 / 7.3024370058 / 0.03994336344384322 / 5.7399601602553275e-06 776 TXNL1_3 18_56602813_A_T / 18_56626612_C_T / 18_56651278_A_T 2.210469276189849e-06 / 0.022001595468935316 / 0.02149358538709261 4.0417773765221675e-09 / 2.767068005468822e-10 / 1.7102012334179478e-05 777 PTPN3_2 9_109436866_A_G / 9_109406452_T_G 2.248398882883789e-05 / 0.008436388558613016 0.022560149794550868 / 0.025748841495573487 778 LAMA3_9 18_23861753_C_T / 18_23915519_T_C / 18_23946123_C_T / 18_23949758_G_A / 18_23954737_C_A / 18_23954739_C_T / 18_23939340_A_C / 18_23713905_CT_C / 18_23846109_T_G 2.2546401848550504e-07 / 0.0006963202810397933 / 1.582829210028338e-05 / 1.6534066895813288e-06 / 2.6769400746243374e-05 / 1.9933398900670928e-05 / 0.0008881294144847822 / 3.0126882423530804e-05 / 3.5426816292959363e-05 0.033914720695717084 / 0.013114315448110179 / 0.03066224880164858 / 0.025703076793439833 / 0.042551605063568684 / 0.030472466536971138 / 0.013225085724631118 / 0.01613050085470659 / 0.04009682047166014 779 MTMR9_3 8_11284836_T_G / 8_11309724_G_A / 8_11322815_A_C 2.349458678158868e-06 / 0.0004653758499732343 / 0.008022838484344897 2.4088220462781546e-11 / 0.0074905636429132404 / 0.008917788804222488 780 ITGA6_4 2_172427981_A_G / 2_172427985_C_T / 2_172484735_A_G / 2_172490965_G_T 2.55642040821661e-05 / 1.1751587238624405e-05 / 0.002854965230943433 / 0.025550057038402886 0.021886276374067117 / 0.023752544661456654 / 5.351259734935356e-06 / 0.007174810273459709 781 KRI1_8 19_10557707_T_C / 19_10558277_G_A / 19_10560316_C_T / 19_10565667_A_T / 19_10565747_G_A / 19_10561817_C_T / 19_10562664_C_T / 19_10565811_G_GCC 2.6474598014609052e-05 / 9.523794655306364e-05 / 0.00011786607794266038 / 0.0001616270444439651 / 3.4012624242046115e-05 / 1.477271100442178e-06 / 1.0798436673597302e-06 / 6.316959826240111e-06 0.00012897741560140272 / 3.792910022705542e-05 / 2.0569928046658807e-05 / 2.711645177509063e-07 / 3.211054485740389e-07 / 1.8153836897508705e-05 / 0.0002329401807770252 / 0.0008450486067550477 782 GBP3_2 1_89007941_G_A / 1_89011034_A_T 2.713567196210831e-05 / 0.047917709012617486 1.221534419837023e-06 / 2.259902209453749e-08 783 FGFR2_2 10_121487530_T_C / 10_121520352_C_T 2.796050535454376e-05 / 9.346629403777272e-05 0.015364585786772819 / 0.004955596968571121 784 TNRC6C_2 17_78049826_A_C / 17_78067796_A_G 2.865420177578161e-05 / 0.003859622145256892 0.03771979541922566 / 0.03295200627528048 785 PDGFRB_2 5_150135511_G_A / 5_150129967_A_C 2.9565587793102473e-05 / 0.0011142332419287124 0.007951396082365123 / 0.010884978116376998 786 ASPH_2 8_61578734_T_G / 8_61638365_TA_T 3.0349566769525607e-06 / 0.014784455717628972 0.00027481062695969863 / 0.0033421074285719613 787 MRPS25_2 3_15065217_A_C / 3_15065038_A_C 3.231333497421803e-05 / 0.03913000849637771 0.0017607662142123156 / 0.008302391831822605 788 CNIH4_2 1_224356827_A_G / 1_224379302_G_A 3.345540294148141e-05 / 1.3298114540105321e-05 8.270232693194595e-06 / 0.004957072960670954 789 STAT5B_2 17_42212246_T_A / 17_42218217_T_TG 3.457612678303974e-05 / 0.009108698459398929 0.049805612849012526 / 0.041598649064757576 790 NRF1_5 7_129690176_C_G / 7_129709261_G_A / 7_129710330_A_C / 7_129711604_C_G / 7_129717099_T_G 3.514964941916984e-05 / 0.0012574856804500286 / 0.0029569614211133396 / 0.0009106050710647207 / 0.0008333980926761285 0.0008588680251565 / 0.0020358531276104324 / 0.001863531871592876 / 0.00048643171799331433 / 0.006420212881434713 791 C21orf58_2 21_46302477_A_G / 21_46322980_A_AG 3.600317129022087e-06 / 0.000178616399448272 0.028316032350682373 / 0.0464048927112107 792 EBF1_2 5_159099526_TA_T / 5_159099526_T_TA 3.7020844162640586e-06 / 0.0061991425888554795 6.309766911659592e-06 / 0.009920112112628023 793 PCNT_10 21_46438359_T_C / 21_46440304_C_T / 21_46442711_A_G / 21_46444647_CTTT_C / 21_46444900_C_T / 21_46444910_G_C / 21_46355631_G_C / 21_46425893_A_C / 21_46444675_T_G / 21_64G446T 3.8924131898677556e-05 / 0.00010294155569212726 / 0.00442543345514155 / 0.0007255960816556072 / 2.666879695038341e-05 / 2.666879695038341e-05 / 0.045239341586552524 / 0.0052653795831940926 / 0.011583428163992472 / 0.0012373038631552345 0.0007850146452497258 / 0.0011784720417395535 / 0.0010237263069919882 / 0.01824823490083048 / 0.00036147873774628185 / 0.00036147873774628185 / 0.0004512031541319047 / 0.01998375792506145 / 0.009046665740785187 / 0.01284951528238673 794 RFT1_3 3_53104238_T_C / 3_53120116_ATTAACTGCAC_A / 3_53120127_T_G 4.1039519054300644e-05 / 0.010916191776172972 / 0.0009241739865608092 0.019143884189355254 / 0.0012736601162827682 / 0.0003755806923286365 795 NGLY1_4 3_25733865_A_C / 3_25736073_G_T / 3_25764388_T_C / 3_25732334_A_C 4.193690016854428e-05 / 1.0629890346566115e-06 / 0.00018111373229034528 / 0.000337635257557846 0.004048589804059987 / 0.0001003348545752524 / 0.008193558074218642 / 0.0008517116761761035 796 SHPRH_2 6_145955343_T_G / 6_145922945_GT_G 4.197525341776357e-06 / 0.02497921302813516 0.0019437040989644704 / 0.0032085441168495693 797 PSAP_4 10_71817510_G_A / 10_71820222_G_A / 10_71823763_G_C / 10_71825769_A_G 4.253559292570684e-05 / 1.4584188008395623e-05 / 0.0007450217858733059 / 7.15024619363838e-07 0.005989723973244358 / 0.004815444492138627 / 0.005093191498317171 / 0.001137729147313085 798 EPG5_4 18_45907942_A_G / 18_45860332_T_G / 18_45967161_TG_T / 18_45949582_G_A 4.41056482155363e-05 / 0.0325761410753079 / 5.0265150457437094e-08 / 0.0009686733993730644 0.00018099150138285703 / 5.454441871402812e-06 / 0.0031405068156816515 / 0.04928013785599337 799 GRB7_2 17_39746744_A_C / 17_39737973_T_C 4.445333626793725e-06 / 3.7814817628535414e-05 0.015646545098240962 / 0.0275943135807812 800 TBC1D5_5 3_17233681_G_C / 3_17238034_T_C / 3_17258641_A_C / 3_17428395_ATG_A / 3_17238102_T_G 4.500069192335354e-07 / 5.287266410953234e-06 / 1.0934340959097885e-06 / 0.00038136339583758066 / 0.0015374412890621536 0.034850654424783314 / 0.048246561657752436 / 0.034850654424783314 / 9.180133184684152e-05 / 0.00428366923460265 801 TTLL3_5 3_9825941_C_T / 3_9826893_A_G / 3_9829346_T_G / 3_9832986_G_A / 3_9835303_G_A 4.506908857236149e-08 / 9.62440960091469e-07 / 6.721794266994746e-08 / 3.966565971028462e-07 / 0.047234941799100816 0.004512931116648239 / 0.009182452462015591 / 0.0016666988915567758 / 0.005845443747610279 / 0.00549007437147901 802 HAUS1_4 18_46118343_C_T / 18_46123257_C_G / 18_46122767_C_T / 18_46118217_A_T 4.791384820535998e-09 / 9.485176947904584e-06 / 0.0008672645013724843 / 0.00028116915718734436 0.0017369506644946814 / 0.009435638863427392 / 0.00147832294217736 / 0.0031860563996751264 803 FGD4_3 12_32640343_A_C / 12_32640545_A_C / 12_32582270_A_C 4.811506604588182e-07 / 0.027930843946287982 / 0.032681639982183666 0.0008756223675282764 / 0.0092856233481216 / 0.0015384650399147507 804 PPDPF_2 20_63522320_T_G / 20_63521771_A_C 5.287951236043515e-05 / 0.00689972604034751 0.043695255169413805 / 0.0005655672033991309 805 ITGA2_2 5_53091493_C_T / 5_53042183_A_C 5.4531358390517686e-05 / 0.03919199794742103 0.043791975990725485 / 0.0012604443318972665 806 SLC44A3_5 1_94839884_A_G / 1_94865029_A_C / 1_94857210_T_G / 1_94857357_C_G / 1_94892383_G_T 5.602338522082008e-05 / 0.046411065532556 / 0.007150508797521116 / 0.017457449518246654 / 0.009632517735858792 0.038972716080465035 / 0.008550555716824466 / 0.016460335501241437 / 0.008036938687219244 / 0.029740691948763408 807 USP4_5 3_49284594_T_A / 3_49305742_G_A / 3_49324936_C_T / 3_49335612_A_G / 3_49302213_T_A 5.782019897669962e-06 / 7.19205729889027e-06 / 1.709904241092868e-05 / 7.19205729889027e-06 / 5.51522445922424e-05 0.0014702427553570136 / 0.0018428609815186782 / 0.0024991863535684788 / 0.0018428609815186782 / 0.0003850173954240535 808 CCDC12_4 3_46922012_T_C / 3_46923707_C_G / 3_46941247_T_C / 3_46923591_T_G 5.914685515407129e-06 / 0.0018228664081414493 / 0.005309522612383735 / 0.004983454832882268 0.030142804350997518 / 0.03284103078371856 / 0.032410896819240385 / 0.04034475330385405 809 TRIOBP_4 22_37723206_G_A / 22_37734378_A_C / 22_37765828_T_TG / 22_37750578_C_T 5.971478816203375e-05 / 0.00027985715683595134 / 0.00029261375791339014 / 0.0030808446512811693 0.0051569691660451255 / 0.009407307485487609 / 0.022947122514129482 / 0.01009941891139795 810 RAF1_2 3_12603508_C_T / 3_12606048_T_TG 6.128646872671697e-07 / 0.0039523881023646075 0.0022616226810353037 / 8.653379217936721e-05 811 FMNL1_5 17_45241411_G_C / 17_45241412_C_G / 17_45243751_T_G / 17_45232440_T_G / 17_45244864_G_C 6.171874985510183e-05 / 0.00015929956646855425 / 0.003538404752618725 / 0.004784366369409091 / 3.9901595948387376e-05 0.0020906187745857413 / 0.0076474907511281205 / 0.013884774496511404 / 0.006430399709476225 / 0.0024365462048673877 812 RIPK4_2 21_41746606_T_G / 21_41746170_T_C 6.423837221659731e-05 / 0.00010177497615683857 0.014247426375762309 / 0.03297049438127817 813 AGPAT5_2 8_6724964_A_C / 8_6757085_A_G 6.429038885162565e-07 / 0.00364477408851887 1.266950151869815e-06 / 0.001321765776974001 814 USP48_3 1_21703696_T_C / 1_21706077_T_G / 1_21706735_G_A 6.450311033122228e-05 / 0.00028299304853152363 / 0.00012669514216415802 0.007845997236531468 / 0.01309954874203597 / 0.004449445235290158 815 AP1M1_8 19_16206608_T_TG / 19_16226612_T_C / 19_16227721_G_A / 19_16228258_G_A / 19_16228904_C_T / 19_16233717_C_G / 19_16234288_T_C / 19_16228794_T_G 6.528413032668653e-05 / 0.0064557081074910596 / 0.0024361725049911105 / 0.01837918810861549 / 0.025114292331133558 / 6.165054004198194e-05 / 0.002051667150159714 / 0.0008804072022582094 0.0008868669473225051 / 0.01491435109247843 / 0.00492438514382162 / 0.0030213758122107693 / 0.00454785100704076 / 6.396974124132157e-05 / 0.007302514064743812 / 0.008904488847639608 816 DAZAP1_2 19_1432575_T_C / 19_1432578_A_C 6.972933286419396e-09 / 0.00010616832462214354 0.008783799588482919 / 0.004625103934387489 817 PACSIN3_2 11_47180569_G_A / 11_47182508_A_C 7.134768403726839e-05 / 0.04020981298829434 0.021285924311691296 / 0.004000006496631303 818 R3HCC1_4 8_23288582_A_G / 8_23291465_G_T / 8_23293365_T_G / 8_23290051_G_A 7.2991599811489e-05 / 5.994421359171259e-05 / 0.012526023152146196 / 0.010041573920909331 0.02377854438814787 / 0.02377854438814787 / 9.39093538138813e-05 / 0.0033896878620269183 819 SERPINB5_10 18_63486810_T_C / 18_63487155_C_T / 18_63489373_G_C / 18_63493054_T_C / 18_63493152_T_C / 18_63503267_T_C / 18_63503488_T_C / 18_63503549_A_G / 18_63503234_G_A / 18_63504 7.512909343200293e-07 / 1.61367941078967e-12 / 0.0017661748524282887 / 0.00358191163139034 / 1.15283914089761e-08 / 3.707481964958598e-05 / 3.699707858963291e-05 / 1.4974781606492456e-10 / 8.547425345240158e-05 / 0.001617719369677095 0.002310192116365421 / 0.0001900079796436893 / 0.0024982561142762962 / 0.004570527834506507 / 2.6119929305428517e-05 / 0.004811319593060203 / 0.00038813827261946135 / 0.0001894559075360232 / 0.008723212833525323 / 0.023248521588281557 820 U2AF1_2 21_43107500_A_C / 21_43107485_A_C 7.700487442691808e-05 / 0.0006563940756543221 3.5456060624197415e-05 / 0.0031649133811599275 821 LLGL2_4 17_75569181_T_A / 17_75558442_C_G / 17_75573695_C_CCT / 17_75575074_T_C 7.971949158890872e-06 / 3.785506483286314e-07 / 0.0064833437780985005 / 0.00395910816955325 0.018355040177942674 / 0.0004418073280201704 / 0.047670437975331784 / 0.004283559000108913 822 PPFIA1_4 11_70365468_A_G / 11_70375250_G_T / 11_70337631_C_G / 11_70331778_TCAAAAA_T 8.1777600824213e-05 / 2.2154751602898654e-10 / 0.007683460638024795 / 2.733195536548977e-07 0.01601938240153477 / 1.0104020665663723e-05 / 0.008528354106314544 / 0.002219921170959074 823 STAG3_2 7_100197862_A_C / 7_100182660_G_A 8.238419261021031e-05 / 0.008737491145039442 0.0017528283507844654 / 0.035261037489752685 824 MYO5B_13 18_49837561_G_C / 18_49875910_A_C / 18_49937217_A_G / 18_49954290_G_A / 18_49847096_G_A / 18_49849562_C_G / 18_49849733_C_G / 18_49880543_A_G / 18_49880568_T_C / 18_49_49_4949 8.380774951798238e-06 / 0.006905476699523033 / 2.4263131433880795e-10 / 1.7494996128043332e-06 / 5.5387782704635815e-05 / 3.8985071268389133e-07 / 7.81858565470932e-07 / 1.54439656564615e-07 / 2.371423829111085e-08 / 8.182928745989 07 / 2.0981325041460703e-11 / 3.691444258026264e-11 0.03791686668587351 / 0.011592306302894794 / 0.0007689742137758647 / 0.011825548378506088 / 0.024802045476053625 / 0.0005688441791387698 / 0.0007265409595720793 / 0.010189243521059816 / 0.00680321425888459 / 7.83580041933832e-07 / 0.004868666362089778 / 9.442141848 825 ZNF441_2 19_11767280_T_G / 19_11778532_C_T 8.6437303626739e-08 / 3.655373741478951e-07 0.00119501780413069 / 0.007941778018462287 826 FAM83H_3 8_143728128_T_G / 8_143725596_G_C / 8_143730455_T_G 9.215742981089235e-05 / 0.005987749784597274 / 0.0009621524329080232 0.005904909381665708 / 0.003207570177222234 / 0.011128551580065676 827 KCNAB2_4 1_6085319_C_T / 1_6095272_T_C / 1_6085347_G_A / 1_6094357_C_T 9.311243022811629e-05 / 0.0002214464879819671 / 0.007488052354416149 / 0.0004024482530986694 0.04271710391545418 / 0.04289813943359165 / 0.010697792728178102 / 0.030197643178852058 828 MMP15_4 16_58038249_C_T / 16_58042518_A_G / 16_58045261_G_A / 16_58037634_A_C 9.375120301838935e-05 / 1.005487978512005e-05 / 0.00013842386491697844 / 0.035127559966572304 0.006545735139458929 / 0.008269298799745639 / 0.016496855574598585 / 3.732680793190984e-05 829 PKNOX1_3 21_43028653_G_C / 21_43028665_G_A / 21_43029807_G_A 9.45086875135022e-05 / 9.45086875135022e-05 / 0.0028391505331848486 0.02993846952653303 / 0.02993846952653303 / 0.04630035756513505 830 CNOT6L_3 4_77720488_T_G / 4_77720486_A_G / 4_77726534_A_C 9.499774295611595e-07 / 0.0011515987198065605 / 1.5337206523072135e-05 0.00045440611666765506 / 0.003812687853894012 / 0.002323583718729919 831 C1orf109_4 1_37683521_C_T / 1_37689469_G_GGT / 1_37689593_G_C / 1_37684175_A_G 9.499906971175951e-07 / 3.357943291134777e-07 / 2.4786643546299445e-07 / 0.03129818295251388 0.0019238150218027989 / 0.005985910424044681 / 0.004025869106193675 / 0.0047335795687796075 832 MAP7_2 6_136361034_G_A / 6_136411526_G_A 9.631600220201912e-05 / 0.00020915694169969668 0.004233710215813943 / 0.03701019146859175

Table 18 shows the biomarkers associated with the ERK_MAPK drug and the degree of reactivity (P-value) of the drug by the table.

In [Table 18], FRH was expressed in the form of "FRH name_number of markers included", and "Var_Drug (pval)" refers to the value of the correlation (P-vlaue) that the marker has on the reactivity of the drug. According to the order of reactivity, the correlation value for each drug is divided into the division factor 『/』, and 『Var_Exp (pval)』 means the correlation (Pvlaue) value that each marker has on the corresponding gene expression. , Also, according to the order of the markers, the values of the reactivity correlation for each drug are classified as the classification factor 『/』.

From these reactivity verification results, it can be determined that the lower the Var_Drug (pval) and Var_Exp (pval), the higher the effectiveness of the corresponding marker as a biomarker for determining drug reactivity.

Meanwhile, in FIG. 40, correlation values (P-vlaue) values of ERK_MAPK drugs of major biomarkers among the biomarkers described in [Table 18] are graphically displayed.

Reactivity biomarker for ERK_MAPK drug and verification result of reactivity with drug No. FRH Variants Var_Drug (pval) Var_Exp (Pval) One INHBE_1 12_57456335_T_G 5.77E-14 0.023018015 2 SMAP1_1 6_70773272_G_A 1.18E-08 0.029985176 3 SPRY4_1 5_142319698_T_G 6.07E-08 0.000420223 4 THEM4_1 1_151909409_A_C 8.56E-08 0.035981352 5 SERPINB1_1 6_2837820_C_G 1.44E-07 0.008676416 6 EIF2B3_1 1_44926782_G_C 7.36E-06 0.00572911 7 DUSP6_1 12_89350540_G_A 8.18E-06 0.001102792 8 TOLLIP_1 11_1295591_A_C 1.13E-05 0.041990571 9 CDC5L_1 6_44387945_G_A 0.000100417 0.000850114 10 PAPD7_1 5_6746131_C_G 0.000186035 0.046879537 11 ABHD2_1 15_89199849_C_A 0.000373834 0.002565266 12 PLEKHM1_1 17_45436185_C_G 0.002692591 0.035787973 13 SMC6_1 2_17731999_A_C 0.003115924 0.045907596 14 RNF38_1 9_36400965_C_G 0.004214532 0.007012003 15 METTL16_1 17_2415256_G_C 0.007239539 0.043637945 16 PARP2_5 14_20351190_T_A / 14_20354336_G_T / 14_20344985_T_C / 14_20354983_A_C / 14_20354994_T_C 0.0003461397642250317 / 0.008144629651779057 / 1.6511185678613746e-06 / 9.423861936900617e-06 / 4.248961897732616e-05 0.0026213592391782425 / 0.0343587058197046 / 0.0388723494826529 / 0.009448771221863612 / 0.035110640891692815 17 CRYL1_6 13_20439533_A_G / 13_20439514_CA_C / 13_20404113_C_G / 13_20404176_A_C / 13_20489466_A_C / 13_20512438_C_G 0.0007457569282103447 / 0.04490288969730257 / 5.4112288097843236e-05 / 0.0004125161353078136 / 7.340308839823958e-10 / 0.0008144017559447111 0.02254568941445808 / 0.006925654927699 / 0.014412490268573512 / 0.0358490969666835 / 0.0036810252474824734 / 0.0005690585314639865 18 MBD2_2 18_54222304_G_C / 18_54224621_A_C 0.0009174927734817775 / 0.003370522943374522 0.041746449937120685 / 0.0024467066581282037 19 NUCKS1_3 1_205727543_G_A / 1_205720599_G_C / 1_205719615_A_C 0.0019226380117114328 / 5.15182042228384e-07 / 5.169743185885884e-06 0.007966391204853542 / 0.0020116543690140926 / 1.829062095579077e-05 20 TMEM8A_4 16_377516_T_C / 16_374277_G_A / 16_377010_C_T / 16_375326_T_G 0.0022458300017618115 / 0.0004991219763661549 / 0.008152821570691773 / 0.00033905970470333573 0.02280191742379471 / 0.008448241096869875 / 0.02464199505583077 / 0.03164430214292932 21 MCM8_5 20_5950428_T_C / 20_5954739_T_C / 20_5967525_G_A / 20_5963301_T_G / 20_5983067_T_G 0.002650766144390827 / 0.0020883309843753076 / 7.538671246466503e-12 / 0.0005138671174250025 / 0.00032159758644408336 0.02450503355623649 / 0.0030061115573713558 / 0.02006455848870967 / 0.0209284066776318 / 0.012878505995892143 22 COPS3_3 17_17280719_G_T / 17_17249049_GAA_G / 17_17280660_A_C 0.0027601645216709264 / 0.0055818454987667495 / 0.009754104106729505 0.019538058668087298 / 0.04875712280071096 / 0.02319033941785423 23 NEDD1_2 12_96937308_A_C / 12_96936634_A_G 0.004287874507177774 / 0.0016187072229015974 0.019399114812349873 / 0.02229964139566365 24 HDAC6_3 X_48803171_T_G / X_48817284_T_G / X_48817251_CAA_C 0.007173863496387051 / 0.0004972749557463768 / 0.0027277691674834114 0.008701773238861378 / 3.6233113107314475e-06 / 0.00929153924222002 25 MRPL39_6 21_25592759_G_A / 21_25601549_G_T / 21_25603910_C_T / 21_25603925_C_T / 21_25604009_G_A / 21_25599683_T_C 0.007753577611892022 / 0.0015571108862256187 / 0.005054758659783033 / 0.00740873550689033 / 0.005591788896050463 / 0.03750113388472616 0.033844596383331746 / 0.005711821633941189 / 0.043198910460816656 / 0.020407458243495952 / 0.026357543170222462 / 0.002961561939886723 26 ZBTB8OS_2 1_32621836_G_A / 1_32634036_A_G 0.010623328091650126 / 0.005807902867508034 0.00035085154745507385 / 0.001609648081432905 27 SNRPC_3 6_34767901_T_C / 6_34767875_CT_C / 6_34767875_C_CT 0.016258858934554518 / 0.0255807459946655 / 0.008409734593854818 0.0021977163744789038 / 0.005833052025345314 / 0.047890724740450176 28 SH3TC2_5 5_149010200_G_A / 5_149026823_T_C / 5_149040673_A_C / 5_149040676_A_C / 5_149004975_C_T 0.036452606469764885 / 7.993368579087101e-05 / 1.313354358475822e-12 / 1.6742742304793365e-07 / 3.0188094863269486e-08 0.005163368200425915 / 0.02459748424962984 / 0.04603790254373362 / 0.03254802106345967 / 0.01898788013634638 29 NUP188_7 9_128970680_G_T / 9_128981422_CT_C / 9_128999694_A_C / 9_128993243_C_G / 9_129003287_A_C / 9_128952722_CAAAA_C / 9_128981422_CTT_C 0.03889727834709586 / 5.679744903985549e-07 / 0.00015792708806478532 / 0.00011477857081826123 / 0.006528287639189813 / 1.3483326927899365e-05 / 0.001011406252669107 0.006235319995753044 / 0.0026090470755132837 / 0.04562376131737803 / 0.034372383646284414 / 0.006351306341421021 / 0.030396670064505107 / 0.0486576378436576 30 PDCD5_2 19_32581360_T_C / 19_32581212_C_G 1.0613555124907784e-06 / 0.01707686442489131 1.930613826710712e-05 / 0.00963168433129465 31 PCDH1_5 5_141865023_A_C / 5_141864261_A_C / 5_141864335_T_G / 5_141854096_T_G / 5_141864895_A_C 1.146087693284126e-13 / 2.954523514000492e-06 / 1.2399540998886776e-05 / 6.010776449757326e-05 / 1.3125365237964413e-06 0.00022379266342278662 / 0.0017861354200376558 / 0.02539846277902666 / 0.023845011173266668 / 0.014684779508972238 32 ARL6IP6_3 2_152718606_T_G / 2_152718941_T_G / 2_152718947_T_G 2.1444201135699293e-06 / 3.4179740940841686e-10 / 5.150737082224498e-05 1.916382486428584e-05 / 0.0014347496711839814 / 0.0018772601891545288 33 TPP1_3 11_6616021_T_G / 11_6619456_A_C / 11_6616207_T_G 3.898164047661344e-05 / 6.206193500590457e-06 / 7.13357999675385e-06 0.03721832122361987 / 0.0021180587349231865 / 0.022734527785541702 34 SLC35B2_2 6_44253096_A_C / 6_44255584_T_G 4.1264755521968e-08 / 2.206940612751773e-06 0.045514675788588387 / 0.0354190738183241 35 ETV5_6 3_186057145_T_G / 3_186057158_T_G / 3_186105591_G_A / 3_186064432_A_G / 3_186057367_T_G / 3_186057421_A_C 4.28224233645744e-14 / 2.8538105380699127e-12 / 3.537860306738235e-07 / 3.53456731728789e-05 / 8.933112160257351e-07 / 2.0618345030808515e-05 0.000899440048018852 / 5.426858809490545e-05 / 0.008678217049363252 / 0.012387170842740151 / 0.01078700094209001 / 0.04370939373064901 36 DUSP4_2 8_29340229_A_C / 8_29337473_A_C 4.4035389796360024e-07 / 0.0013351841168008725 0.01853773742959819 / 0.013684370845169195 37 ST3GAL4_3 11_126408340_T_G / 11_126406566_A_C / 11_126424657_A_G 4.582342844339244e-12 / 1.1939071093750443e-06 / 6.212889562458534e-09 7.802484819683297e-05 / 0.006286854884921811 / 0.03738872157996522 38 SKP2_3 5_36183922_T_C / 5_36168236_A_G / 5_36168246_T_G 4.974059042110084e-09 / 2.3219549423702208e-12 / 1.6076332463417848e-08 0.008092624659189506 / 0.01597032245832584 / 0.022784487945753537 39 GPBP1_3 5_57230956_G_A / 5_57231420_T_C / 5_57251232_G_A 4.99115882517327e-06 / 1.8819931578981247e-06 / 2.491196233571318e-05 0.038048986044057084 / 0.04556667822911722 / 0.018325268985280727 40 CMTM7_2 3_32441841_T_G / 3_32454197_C_G 5.20316947282785e-11 / 1.865488768400554e-06 0.022587609002975642 / 0.027278626571090647 41 LRP5_2 11_68429633_T_G / 11_68448944_A_C 8.179359573414423e-10 / 2.733681134387847e-06 0.01579807768279053 / 0.024681714140317668 42 ETV4_2 17_43544973_A_C / 17_43533230_T_G 8.216801793356959e-07 / 9.218453009083366e-06 0.025227174262734704 / 0.0007956602344066278

Table 19 shows the biomarkers associated with IGFR drugs and the degree of reactivity (P-value) of the drugs.

In Table 19, FRH was expressed in the form of "FRH name_number of markers included", and "Var_Drug (pval)" refers to the value of the correlation (P-vlaue) that the marker has on the reactivity of the drug. According to the order of reactivity, the correlation value for each drug is divided into the division factor 『/』, and 『Var_Exp (pval)』 means the correlation (Pvlaue) value that each marker has on the corresponding gene expression. , Also, according to the order of the markers, the values of the reactivity correlation for each drug are classified as the classification factor 『/』.

From these reactivity verification results, it can be determined that the lower the Var_Drug (pval) and Var_Exp (pval), the higher the effectiveness of the corresponding marker as a biomarker for determining drug reactivity.

Meanwhile, in FIG. 41, correlation values (P-vlaue) values of IGFR drugs of major biomarkers among the biomarkers described in [Table 19] are displayed in a graph.

Reactivity biomarker for IGFR drug and verification result of reactivity with drug No. FRH Variants Var_Drug (pval) Var_Exp (Pval) One SEPT6_1 X_119618658_T_G 1.08E-09 0.00240717 2 EPHA2_1 1_16148437_A_C 2.39E-08 0.003022958 3 VRK1_1 14_96853031_T_G 3.01E-06 0.034233405 4 ACTR3_1 2_113934245_G_T 4.92E-06 0.01245207 5 FOS_1 14_75280999_A_C 6.24E-06 0.001488063 6 FCHO2_1 5_73082876_ATT_A 1.08E-05 0.029256929 7 RAC1_1 7_6401802_T_G 2.22E-05 0.003141263 8 CXCR5_1 11_118886492_C_G 6.30E-05 0.044645013 9 KCNQ5_1 6_72622312_C_G 8.39E-05 0.005821769 10 ACSS2_1 20_34920910_T_G 8.92E-05 0.038456731 11 CRLF3_1 17_30792416_T_G 0.000107788 0.014789711 12 TSEN34_1 19_54192354_T_G 0.000113175 0.001848481 13 GTF2IRD1_1 7_74512993_A_G 0.000122837 0.006481631 14 CECR1_1 22_17188516_G_C 0.000127223 0.003052868 15 MAP4K1_1 19_38617327_T_G 0.000134054 0.013203631 16 PAPSS2_1 10_87727355_T_G 0.000165034 0.012652487 17 LAMC1_1 1_183131172_CAA_C 0.000221332 0.002417084 18 TBX21_1 17_47742656_A_C 0.000232988 0.004538883 19 PNRC2_1 1_23961703_G_C 0.000287734 0.015853081 20 HSPG2_1 1_21885485_A_C 0.00029294 0.028105373 21 CD72_1 9_35610848_A_C 0.000296281 0.049937736 22 KLF3_1 4_38689006_A_C 0.000348148 0.015121455 23 ZNRF3_1 22_29048501_A_C 0.000348188 0.024970519 24 ASAP2_1 2_9399979_T_G 0.000416146 0.021780475 25 CCDC69_1 5_151185396_T_C 0.000422551 0.005439839 26 EPS15_1 1_51472751_T_G 0.000562256 0.00454227 27 CBR1_1 21_36071267_G_C 0.000703843 0.005777456 28 CST3_1 20_23634133_A_C 0.000813367 0.047435887 29 IGF1R_1 15_98934682_T_G 0.00081535 0.004668174 30 MEI1_1 22_41699656_A_C 0.000847426 0.019192604 31 PTPN6_1 12_6946697_T_C 0.000924277 0.002400753 32 PMEPA1_1 20_57700062_A_G 0.000939285 0.036764657 33 WASL_1 7_123692324_GA_G 0.001014849 0.000396379 34 ARHGAP15_1 2_143228433_T_C 0.001096444 0.039221572 35 CLDN12_1 7_90413108_T_G 0.00113931 0.004520847 36 UACA_1 15_70669470_GA_G 0.001211403 0.03571568 37 TRIM2_1 4_153276097_A_G 0.001260338 0.011894098 38 RCC2_1 1_17413487_C_A 0.001306044 0.02349276 39 CD48_1 1_160711863_GA_G 0.001708644 0.04718285 40 GLCE_1 15_69261053_A_G 0.001722968 0.004293961 41 C21orf91_1 21_17793434_T_G 0.001758128 0.044828498 42 SIGLEC10_1 19_51417063_T_G 0.00177184 0.045299996 43 NCKAP1_1 2_182967372_CA_C 0.001831659 0.004822611 44 CD86_1 3_122103557_A_C 0.001895858 0.046671667 45 ERRFI1_1 1_8013331_A_G 0.001920351 0.000188249 46 PTPRC_1 1_198703381_A_C 0.001955402 0.027037687 47 CTDSPL_1 3_37957127_T_G 0.002306486 0.04933152 48 TAF4B_1 18_26286027_C_A 0.00252716 0.005234164 49 CDC42BPB_1 14_102939620_T_G 0.002756257 4.78E-05 50 CTBP2_1 10_125026073_A_G 0.002878802 0.03391949 51 RASAL3_1 19_15458567_G_C 0.003342618 0.038134018 52 HLA-DOB_1 6_32813293_A_C 0.003408106 0.048853006 53 WAS_1 X_48691219_A_C 0.00381355 0.02612273 54 HBS1L_1 6_134965300_CA_C 0.004012929 0.010966837 55 FCRL5_1 1_157518564_T_C 0.004367637 0.023539142 56 UHRF2_1 9_6482002_G_T 0.004387102 0.007025127 57 SPR_1 2_72891611_A_C 0.005381455 0.000101783 58 DHX32_1 10_125867071_T_C 0.006025442 0.015306739 59 DAG1_1 3_49531399_T_G 0.006122816 0.000829773 60 RAVER2_1 1_64768580_T_G 0.007604338 0.049067483 61 KIAA0922_1 4_153635457_C_T 0.007681106 0.042172485 62 ITGAV_1 2_186637080_T_G 0.0079744 0.00113911 63 MSL3_1 X_11772199_A_C 0.00797531 0.040182738 64 LAPTM5_1 1_30733959_T_C 0.008095451 0.005337526 65 TPBG_1 6_82364929_T_C 0.009219323 0.003828919 66 CD52_1 1_26320120_TAA_T 0.009857578 0.041028395 67 APOBEC3G_1 22_39086265_G_T 0.009915615 0.042244805 68 ZNF107_1 7_64708051_G_A 0.010400777 0.013846694 69 PALLD_1 4_168691310_GT_G 0.011706523 0.009714355 70 WTAP_1 6_159753424_T_G 0.01384856 0.00215073 71 HCLS1_1 3_121634273_T_G 0.019280657 2.45E-06 72 AVPI1_1 10_97677649_A_G 0.021081758 0.001581419 73 FAM129B_1 9_127578987_C_T 0.021421759 0.016089528 74 SH3RF1_1 4_169096709_G_A 0.024084182 0.008799276 75 DR1_1 1_93361899_T_A 0.025156433 4.48E-05 76 CTTNBP2NL_1 1_112457049_C_A 0.028077079 0.00620874 77 PPP3CC_1 8_22539268_TC_T 0.032546359 0.004572653 78 WIPF1_1 2_174585550_T_G 0.037854213 0.000483959 79 RNGTT_1 6_88769645_C_T 0.04013553 0.002545266 80 CUEDC1_1 17_57873465_G_A 0.046175827 0.009658282 81 TMEM106A_2 17_43216747_A_C / 17_43216763_T_C 0.00010599595448116978 / 0.0011257303404920308 0.0005249300563644175 / 0.0005036765332449491 82 ARHGAP9_2 12_57474996_G_A / 12_57474460_G_A 0.00010627135291362362 / 0.0006872861852919692 0.036897912823510064 / 0.04135748735535435 83 ARHGAP25_3 2_68775067_A_G / 2_68818005_T_G / 2_68818023_T_G 0.00011953760418312583 / 1.4150706205617486e-06 / 0.0059084060389890105 0.04538887525617117 / 0.0040433016624282225 / 0.00032630206809361283 84 LMNA_2 1_156134461_T_G / 1_156139242_AT_A 0.00013744315797654898 / 0.021258069595818274 0.029742625031540286 / 0.04237931129547261 85 DAGLA_2 11_61734985_A_C / 11_61728297_A_C 0.00016688573126791192 / 8.09952511657234e-05 0.004132304336839055 / 0.025660366426589504 86 NR2F6_2 19_17240636_T_G / 19_17232479_A_C 0.0002005112664246795 / 0.004658617789678825 0.0007905076911971658 / 0.04560309985715085 87 PLEKHA1_2 10_122406608_C_A / 10_122426897_T_G 0.0002168843436880945 / 0.005333013480801039 0.013835632948640248 / 0.02718721223708819 88 APP_2 21_25881669_T_G / 21_25881706_A_T 0.00025836883792981226 / 0.012490170798802495 0.0009005203285702301 / 0.007363278374314075 89 ATP1B1_2 1_169127312_A_G / 1_169131404_A_C 0.0002769045008439269 / 0.0004647954716516378 0.009381431280957959 / 0.04764456683437238 90 IL10RA_2 11_117999603_A_C / 11_117999569_T_G 0.0003635149788055047 / 0.002791509228208489 0.033136103226175016 / 0.042909053419655285 91 ERICH1_7 8_658279_A_G / 8_659132_C_G / 8_659777_T_G / 8_666991_A_G / 8_673593_G_A / 8_659879_A_C / 8_664843_G_C 0.00036987702944603015 / 5.389836081615414e-05 / 0.042347501906470714 / 0.03423827293146818 / 0.002457155038695027 / 0.005217531740497581 / 0.03193881349739397 0.004174871941240723 / 0.0054140514901705895 / 0.007294372779032101 / 0.0012649483439199085 / 0.01865482112843118 / 0.0461414202945825 / 0.005281332497371782 92 ITGB5_4 3_124769064_T_G / 3_124809087_T_G / 3_124817591_T_G / 3_124859372_A_C 0.0004279586059829587 / 0.0005503781084358106 / 2.8998064871450438e-05 / 0.007293322508081707 0.0006588536356118503 / 5.4585187494895796e-05 / 0.004666117329251896 / 6.144253538463827e-06 93 RFTN1_4 3_16357670_G_A / 3_16369972_C_G / 3_16433938_A_G / 3_16316966_A_C 0.0005124144917873522 / 0.0007740692582134723 / 0.02739900235302105 / 1.3310696006188425e-05 0.014764917085914387 / 4.009218111239421e-08 / 9.30606513108498e-07 / 0.008243705342181723 94 RBFOX2_4 22_35759903_A_G / 22_35746471_A_C / 22_35761128_GA_G / 22_35745982_A_C 0.0005772251529531363 / 0.0026032665751075587 / 0.0005990432899641425 / 0.00370365047461572 0.0021501446732444386 / 0.003606660377686972 / 0.04845122900481105 / 0.009865449869643949 95 VSIG10_3 12_118095590_T_G / 12_118073908_T_G / 12_118095640_G_C 0.0006180518934147943 / 0.000288504312752602 / 0.003668316042902092 0.013058144491121623 / 0.0019761216603789984 / 0.03443934455659579 96 PLEKHG3_2 14_64741663_T_G / 14_64743474_T_G 0.0007814263254356411 / 0.001157048611523175 5.022222887595109e-05 / 0.0004341351157000161 97 ATP11A_7 13_112832759_A_G / 13_112871823_T_C / 13_112860417_A_C / 13_112810736_A_C / 13_112856140_A_C / 13_112832768_A_C / 13_112860332_A_C 0.0007951918344761818 / 0.0005482830943215422 / 0.0008173410245384687 / 0.00028609539850556404 / 0.0005652380914145368 / 0.01755140978606275 / 0.0026211055327575693 0.03593739412008719 / 0.030074291108272512 / 0.013638179892540932 / 0.02325523862538697 / 0.008605914805152383 / 0.0022773790348338983 / 0.006067631423556552 98 RUNX3_2 1_24907301_T_G / 1_24907326_T_G 0.0008468237773895464 / 0.006925491973632575 0.0479402881785652 / 0.03367486268556343 99 CTTN_3 11_70419876_A_C / 11_70419880_T_C / 11_70407283_C_T 0.000966697322875658 / 3.5345921815367516e-05 / 0.005641133258474765 0.00030309409522359497 / 0.003131141961303907 / 0.005941149857145408 100 CCDC28A_2 6_138785343_A_C / 6_138792859_T_C 0.0013622718680866052 / 0.005185054082793079 0.011499421256994664 / 0.046299906365056015 101 CD63_3 12_55725557_A_C / 12_55725568_A_C / 12_55727027_A_C 0.0015370519252913715 / 4.143328592583745e-05 / 0.0004442658715243917 0.006833645667760305 / 0.006277176385590093 / 0.0005016030317793939 102 SCARB2_2 4_76179751_A_C / 4_76179754_T_C 0.0016868597515864868 / 0.0015619118205883007 0.009508010711643462 / 0.003674712454161551 103 TJP1_4 15_29737354_A_C / 15_29761137_A_C / 15_29761418_A_C / 15_29718609_T_G 0.001722668303128766 / 0.001802650233952311 / 0.0039948883415691075 / 0.0004981143114140755 0.03635480241931981 / 0.005695684405240236 / 0.0032087876676378537 / 0.035918560945748516 104 CD84_2 1_160549875_A_G / 1_160550877_C_G 0.0018095916002787247 / 0.0007689474612337844 0.011914227680681896 / 0.04088607952168802 105 IKZF1_3 7_50368194_A_C / 7_50382645_A_C / 7_50387420_G_C 0.0018105241430139086 / 0.014707321465940356 / 0.001698752501804824 0.008403541889994377 / 0.009343110426337882 / 0.005840601801883746 106 LCP1_3 13_46143111_T_C / 13_46143326_T_G / 13_46143333_A_T 0.0018838737568387656 / 0.0030138622548272647 / 0.002533014213361492 0.004087453394348643 / 0.0014213406956657436 / 0.005160539969200112 107 FAM177A1_2 14_35081207_T_C / 14_35081218_T_C 0.0021562993680550448 / 0.0011900365723686852 0.020934419309292008 / 0.02682119468565008 108 WDR91_2 7_135211631_T_C / 7_135187272_A_C 0.0024692334154964657 / 0.032950442555311085 5.806021129546451e-05 / 0.006217596359933296 109 KLHL6_3 3_183492078_A_C / 3_183508233_G_T / 3_183508495_A_C 0.0026331756981726236 / 0.022647868110278375 / 7.774725762863598e-05 0.03828309904439229 / 0.005722620392157443 / 0.025101287121564474 110 ZNF543_2 19_57329179_A_G / 19_57328339_A_C 0.002905904571144909 / 0.0017155256244295665 0.0030296713890405878 / 0.0008395371531401164 111 PLEK_6 2_68380987_A_C / 2_68380990_A_C / 2_68386526_T_G / 2_68388306_A_G / 2_68388311_A_G / 2_68395610_G_T 0.0029347945425916644 / 0.002463266314490245 / 0.0008850637706738338 / 9.333617954680645e-06 / 0.0006950651263355477 / 0.0073361864658662125 0.0018651167043750433 / 0.004434568689990568 / 0.0232360676072928 / 0.012112306050675708 / 0.028732570109628937 / 0.04207168924285536 112 KDM4C_2 9_6990364_G_T / 9_7103596_C_T 0.0029959320396048127 / 0.031190087077651845 0.01165227785409256 / 0.0003043755324224803 113 STAG3_6 7_100197862_A_C / 7_100197337_A_T / 7_100197348_T_C / 7_100201126_G_C / 7_100180467_A_G / 7_100202616_A_T 0.003032352954227882 / 0.0003006428065929603 / 0.0015227072304436168 / 7.395320763427399e-05 / 2.7805601294277643e-05 / 0.0008727651283899594 0.0017528283507844654 / 0.0366941229125814 / 0.023320205307304158 / 0.027602097077102532 / 0.04660308396540184 / 0.020109594472644786 114 WDFY4_2 10_48733932_A_G / 10_48709976_C_T 0.00343399726598083 / 0.014958425459696244 0.04160917875360734 / 0.036092320181802036 115 PEX3_2 6_143462894_AT_A / 6_143468044_A_T 0.0038068988591272368 / 0.004816984657632503 0.01772831437707046 / 0.001265609891969809 116 FERMT3_2 11_64207498_T_G / 11_64220073_T_G 0.004734854868796705 / 0.0003860702269228193 6.601869405274685e-06 / 0.034308160983635066 117 ARHGAP5_3 14_32092970_T_C / 14_32154828_T_C / 14_32092963_G_C 0.00497062236861118 / 0.0024371349542205195 / 0.03352695059876293 0.000109609141495362 / 0.0028505632724505807 / 0.007275592799482284 118 NGLY1_3 3_25733762_T_C / 3_25736073_G_T / 3_25732334_A_C 0.0050051985544428655 / 0.00013354579539043645 / 0.00040433124284776166 0.0004571643127465467 / 0.0001003348545752524 / 0.0008517116761761035 119 NCKAP1L_3 12_54532103_A_T / 12_54509948_A_C / 12_54542688_G_C 0.005115130095563281 / 0.006142923665719964 / 0.003395761947631717 0.006178462220094093 / 0.01506335399115959 / 0.04657402586559346 120 DCK_2 4_71023692_C_A / 4_71022615_CTT_C 0.00551147320732032 / 0.003204858946259472 0.03456399228988244 / 0.04731976901534782 121 CNOT10_2 3_32705030_A_G / 3_32717271_G_A 0.005986207049477181 / 0.010027593265925021 0.0007110070373588129 / 0.0032142136890770555 122 ZNF430_2 19_21033730_G_A / 19_21022773_T_G 0.0060011071152059935 / 0.001269711279469131 3.875366882434858e-05 / 0.024171318376603662 123 DIRC2_2 3_122795117_A_C / 3_122856322_A_G 0.006254194164645703 / 0.003207873756680403 0.006533610459085206 / 0.013416690563532 124 DENND1C_2 19_6469618_A_C / 19_6466439_T_G 0.0067186287718049645 / 0.0016600261620732227 0.03949757317188018 / 0.022653353998851232 125 MRPL39_3 21_25592788_C_A / 21_25601549_G_T / 21_25599683_T_C 0.007244177399862964 / 0.02581153853071456 / 0.006446955687932745 0.0040263096113157286 / 0.005711821633941189 / 0.002961561939886723 126 POLH_2 6_43587207_T_G / 6_43587205_A_G 0.007282790737761695 / 0.004119102235979657 0.002197498680435875 / 0.0001905626583652103 127 LTBP3_4 11_65547976_T_G / 11_65547974_A_G / 11_65541348_A_C / 11_65543270_A_C 0.008230993013661442 / 0.002905381602762654 / 3.41563836791927e-05 / 0.000404704876316852 0.0010020580443514707 / 0.013780067605462305 / 0.02423580877660449 / 0.030868539513201374 128 CCND1_2 11_69650913_A_G / 11_69643258_A_C 0.009099246706999426 / 0.0062885656582625715 0.024298615321604846 / 0.0008578909246964013 129 CTNNA1_4 5_138812304_T_G / 5_138933920_C_T / 5_138932696_A_G / 5_138812295_G_A 0.009367597372283164 / 6.3503870330673816e-06 / 0.025253708380473885 / 0.0007665667912501635 0.013339032203366944 / 0.00010488952235634391 / 0.007557173168109447 / 0.014548265287747147 130 WDR7_2 18_56679573_T_G / 18_56781547_G_A 0.00936770621562205 / 0.0029337854053434692 1.7583606026050092e-08 / 0.0071713352600959014 131 RCL1_5 9_4844704_T_C / 9_4844778_A_C / 9_4849647_T_C / 9_4860917_G_GT / 9_4860980_G_A 0.01015934986765833 / 0.008166765063815772 / 0.013723578341305795 / 0.006228375621470136 / 0.0009546809601140933 0.001687161016128972 / 0.0053342789487147045 / 0.004306767506877943 / 1.3652309819438526e-05 / 0.014590769537426704 132 ZCCHC14_5 16_87414470_A_C / 16_87411666_T_C / 16_87412604_T_G / 16_87412609_T_G / 16_87407905_T_G 0.01093006007749231 / 0.004904074942282202 / 0.0043682847900583565 / 0.00032200703750807235 / 0.00016922609654741882 0.007871655864135534 / 0.012673355773035487 / 0.00292819630706063 / 0.0093411624607831 / 0.04674575207321762 133 TOM1L1_3 17_54937096_G_T / 17_54937101_G_T / 17_54947274_A_C 0.011389249245863157 / 0.02378503173158879 / 6.37493870407225e-05 0.0005351253630963304 / 4.7382046214109506e-05 / 0.0003719570020930906 134 SVIL_2 10_29532000_A_C / 10_29486218_G_T 0.014203541816552456 / 3.6685991514458535e-06 0.005199248570547408 / 0.02127330473082788 135 TEAD4_2 12_3019250_C_T / 12_3022032_A_C 0.02289390603064881 / 0.0001066489771189534 0.0016254072731388984 / 0.0001892435681560084 136 ARHGAP30_2 1_161052161_T_G / 1_161069551_T_G 0.026797750313656932 / 0.0002673414213531623 0.0011705834898046734 / 0.030642225735204174 137 FMNL1_3 17_45232440_T_G / 17_45238511_T_G / 17_45238503_C_G 0.02756877460315332 / 0.0011473580213809565 / 0.0021134470829949274 0.006430399709476225 / 1.3130360508344227e-05 / 0.014111760701313713 138 CD151_3 11_836023_C_T / 11_836227_A_G / 11_835877_C_T 0.031310628277621426 / 0.01189492161114428 / 0.0465236859230004 0.004311678571283407 / 0.001633994415617101 / 0.005759250847020773 139 MBD2_2 18_54204938_G_A / 18_54224621_A_C 0.032527518290623295 / 0.02387217907579878 0.007481293790069707 / 0.0024467066581282037 140 ACAP1_2 17_7350305_C_T / 17_7343627_T_G 0.03440244080220003 / 9.989468867792128e-05 0.009955377908509965 / 0.02484432576482206 141 RHPN2_4 19_33002924_G_A / 19_33044231_A_G / 19_33044540_A_C / 19_33011638_C_G 0.03758598191114063 / 6.498164345874758e-05 / 0.0019234652198936038 / 0.0005607094271426628 0.001694407500706198 / 0.0003445437417821702 / 0.0007353894363862997 / 0.0002119158667786005 142 RASSF2_3 20_4797919_T_G / 20_4784304_T_C / 20_4784247_T_G 0.037902749156553485 / 0.011694257494444695 / 0.00032929741865870437 0.007153311060028534 / 0.0020239510039769416 / 0.0013542591543729706 143 MYO1G_4 7_44965836_A_C / 7_44970706_A_C / 7_44964431_G_T / 7_44979051_A_C 0.04191223689634028 / 0.01979144289427551 / 0.00017645318680118606 / 0.041733273291402466 0.007221347246269528 / 0.002699507313002306 / 0.005180419499391653 / 0.0010403929060933288 144 PIK3CD_4 1_9720778_T_G / 1_9720785_A_G / 1_9719895_T_G / 1_9718938_A_G 1.0253516427976307e-05 / 0.0046476512085552105 / 0.00011802831952668278 / 0.006759908616419049 0.0012148539768169404 / 0.0398063487615097 / 0.0044497374818740715 / 0.04703097613769788 145 PTGR1_2 9_111594107_A_G / 9_111578959_GAA_G 1.5065359948490627e-06 / 0.005936401163136037 0.00764869645742515 / 0.03809849817293055 146 SH3D19_3 4_151122202_T_C / 4_151148202_G_T / 4_151175208_T_G 2.2029420860104835e-05 / 0.0016057485146252267 / 0.0049299501495510155 0.00026537095134489047 / 0.004030165987762314 / 0.036616308047703286 147 DTNBP1_2 6_15662698_A_G / 6_15662701_T_G 2.9366152452741533e-06 / 0.0006517798782510246 0.0063060334020981846 / 0.001004314451212422 148 ZNRD1_3 6_30062280_G_A / 6_30062358_G_A / 6_30062412_T_A 3.654974597084793e-05 / 1.1618445697892011e-05 / 0.0003334426304369216 0.006713962039550535 / 0.011500969330972352 / 0.02821821301850212 149 SPATS2L_7 2_200329386_C_A / 2_200412288_CT_C / 2_200329511_A_C / 2_200412421_T_G / 2_200412425_T_G / 2_200477943_T_G / 2_200473083_GAA_G 4.207550681496029e-05 / 0.0004415561732387749 / 2.0249110903712733e-05 / 6.324482115669083e-05 / 0.00042055460201680485 / 1.4403669192542887e-05 / 0.007061797305907755 0.0033487592228469143 / 0.011019446375268936 / 0.02491924164389806 / 0.03547678698863923 / 0.024316311222524558 / 0.016080388811817628 / 0.0009052273948575811 150 ELOVL5_4 6_53295600_A_G / 6_53295602_T_G / 6_53291875_T_C / 6_53291854_T_G 4.333948606334787e-05 / 9.154580881914281e-06 / 0.002303807174924029 / 0.010895023484809672 0.0008036056664569972 / 0.0007993551420952537 / 0.0030362229822457412 / 0.005396507263205953 151 AGER_6 6_32183680_C_G / 6_32183336_A_C / 6_32180626_G_C / 6_32182537_A_C / 6_32182532_A_C / 6_32180983_T_G 4.3474785520824183e-07 / 0.0008401867950240421 / 0.00012577188862559035 / 7.864018103130946e-05 / 0.0001383347487645318 / 0.0006412069737516832 0.026487158302874552 / 0.0008365781303084246 / 0.018710849801424196 / 0.024237923466307005 / 0.005092878554310726 / 0.028565251544064637 152 KLHL18_3 3_47319581_T_G / 3_47344095_C_A / 3_47319585_T_G 5.8893512793953086e-05 / 0.003560559459732024 / 0.0014314792247920815 0.013218876001835087 / 0.0063137500959640856 / 0.0442868915202707 153 RBM6_6 3_50054242_G_T / 3_50054246_C_T / 3_50054250_C_T / 3_50054257_G_T / 3_50054263_T_G / 3_50066429_G_T 9.610797412978416e-06 / 0.0004692267600390496 / 0.001169115137001947 / 0.016014825049119413 / 0.00038946159538077817 / 6.545113568163317e-06 0.0124136469122058 / 0.0004024483543288937 / 3.272618868931358e-05 / 5.8729619078742086e-05 / 0.00033057063887385755 / 0.0016854676901857401

Table 20 shows the biomarkers associated with the MITOSIS drug and the degree of reactivity (P-value) of the drug by the table.

In Table 20, FRH was expressed in the form of "FRH name_number of markers included", and "Var_Drug (pval)" refers to the correlation value (P-vlaue) value of the corresponding marker on drug reactivity. According to the order of reactivity, the correlation value for each drug is divided into the division factor 『/』, and 『Var_Exp (pval)』 means the correlation (Pvlaue) value that each marker has on the corresponding gene expression. , Also, according to the order of the markers, the values of the reactivity correlation for each drug are classified as the classification factor 『/』.

From these reactivity verification results, it can be determined that the lower the Var_Drug (pval) and Var_Exp (pval), the higher the effectiveness of the corresponding marker as a biomarker for determining drug reactivity.

Meanwhile, in FIG. 42, correlation values (P-vlaue) values of the major biomarkers among the biomarkers described in [Table 20] for MITOSIS drugs are displayed in a graph.

Reactive biomarker for MITOSIS drug and verification result of reactivity with drug No. FRH Variants Var_Drug (pval) Var_Exp (Pval) One CYR61_1 1_85581605_TA_T 5.27E-05 0.000620768 2 MYB_1 6_135201764_A_C 0.000110474 0.008038119 3 MYH9_1 22_36302635_A_C 0.000236116 0.040823397 4 SNX24_1 5_123023772_TA_T 0.00028033 0.010215104 5 CHAF1A_1 19_4442532_T_C 0.000284751 0.010330163 6 CASP8AP2_1 6_89846678_CT_C 0.000313931 0.000126501 7 MTF2_1 1_93137118_TA_T 0.000462823 0.036903175 8 EGFR_1 7_55170771_T_G 0.000668389 0.004588325 9 ACVR1_1 2_157799371_CA_C 0.000905558 0.016548442 10 MED12_1 X_71132797_T_C 0.000941588 0.024279673 11 TRA2B_1 3_185921167_T_C 0.001087771 0.003158761 12 CYB5R3_1 22_42619486_G_T 0.001094814 0.002582708 13 NFX1_1 9_33303208_A_G 0.001100893 0.023431449 14 UACA_1 15_70669470_GA_G 0.001412253 0.03571568 15 MOK_1 14_102304907_T_C 0.001776612 0.001629205 16 RNF138_1 18_32123591_T_C 0.001798779 0.018606829 17 NMT2_1 10_15119275_A_C 0.002227268 0.015194231 18 DLG2_1 11_83980458_A_G 0.002667354 0.014824348 19 RIN2_1 20_19990244_G_A 0.002695061 0.013004393 20 DHX15_1 4_24540080_CT_C 0.003782084 0.012007783 21 CD276_1 15_73702902_T_G 0.00386155 0.020273648 22 HDAC2_1 6_113944423_T_C 0.004344928 0.041935697 23 PIAS4_1 19_4039058_G_C 0.005375712 0.037776153 24 ARHGAP15_1 2_143216291_G_A 0.005719356 0.035966273 25 STRBP_1 9_123266116_C_G 0.006459968 0.001078377 26 MYO1C_1 17_1484178_C_T 0.007569353 0.007802374 27 EPB41_1 1_29015578_GA_G 0.007616579 0.046541231 28 PRDM2_1 1_13823349_T_A 0.00796288 0.011003429 29 MDM4_1 1_204536848_GA_G 0.008010095 0.021420681 30 C1R_1 12_7091679_A_C 0.00873535 0.0246229 31 RGS16_1 1_182600365_T_G 0.009039587 0.036240935 32 KIFC3_1 16_57765532_T_G 0.009062011 0.038497261 33 NOTCH2_1 1_119922384_T_A 0.009876287 0.022769433 34 PRPF38A_1 1_52416794_T_G 0.012365097 0.004382879 35 U2AF1_1 21_43093000_GT_G 0.018718881 0.003527509 36 FNDC3B_1 3_172328905_GT_G 0.019450759 1.78E-05 37 ITPRIPL1_1 2_96325641_T_G 0.024457637 0.004828474 38 PRKCB_1 16_24174494_CT_C 0.029704271 0.000670802 39 GMEB1_1 1_28702335_T_A 0.031116839 0.003887013 40 IL6ST_1 5_55960635_CT_C 0.045023867 0.00567988 41 SRGAP1_1 12_64142411_T_C 0.046097342 0.006505853 42 DNMT1_1 19_10162649_G_A 0.048749303 0.001347433 43 NPC1_2 18_23540944_CT_C / 18_23539283_G_A 0.00011218638512848764 / 6.166244499849825e-05 0.040822963170832685 / 0.020956228007299703 44 KDM2B_2 12_121579943_C_CA / 12_121534367_T_A 0.0002469480356989407 / 0.00024928370737718086 0.01794421156168876 / 0.01671856514998881 45 MET_3 7_116740945_T_G / 7_116757685_T_G / 7_116795676_T_G 0.00037055097855276256 / 0.003772251227706767 / 0.04454843008676103 0.00017295700570667475 / 5.0554093231126755e-05 / 0.0006156874780574698 46 WWTR1_2 3_149669685_C_T / 3_149669894_G_A 0.0006147608436462098 / 0.0050779807840600905 0.040303211258058205 / 0.014886977556994025 47 RPRD2_2 1_150470594_A_C / 1_150473591_C_T 0.0006254084658607492 / 0.029513176305296374 0.04999439760188915 / 0.008299610316019734 48 PHIP_9 6_78946845_A_T / 6_78965984_A_G / 6_78947674_G_A / 6_78954723_T_C / 6_78955493_T_A / 6_78969860_A_G / 6_78985312_C_T / 6_78998206_C_T / 6_79043075_T_C 0.0007025290839441325 / 0.0008446291153155781 / 0.010121938819521418 / 0.017201835088518632 / 0.014930588444064525 / 0.02454094082336056 / 0.009915783788926756 / 0.0023583595976247713 / 0.011026610846676282 0.0325055100647953 / 0.0325055100647953 / 0.0010048550446085317 / 0.00648756713202656 / 0.009594339103514994 / 0.0017203137452171692 / 0.0007527047164367361 / 0.006763071535609179 / 0.0016364259457283912 49 USP37_2 2_218485635_CAAAA_C / 2_218455538_T_G 0.0008931966771009113 / 0.00047307780771944745 0.04869664909579453 / 0.006248282014078397 50 RRAS_3 19_49636811_C_T / 19_49636835_G_A / 19_49636989_C_A 0.0012180086241795427 / 0.0008453114718541902 / 0.00389443225116509 0.011066495702872568 / 0.008806050890865063 / 0.010977696307794636 51 SHPRH_7 6_145910334_C_A / 6_145922445_C_T / 6_145923607_A_G / 6_145947487_T_A / 6_145948270_A_C / 6_145955343_T_G / 6_145922945_GT_G 0.0015751671472739686 / 0.008305307007300559 / 0.003356044877090312 / 0.00413644978183887 / 0.009574107378650136 / 0.0002467850170635296 / 0.0028322412885894953 0.0007641881109242402 / 0.0008695206428685066 / 0.0004025103622500861 / 0.0002754715942379004 / 0.020534325332750382 / 0.0019437040989644704 / 0.0032085441168495693 52 LAMB2_2 3_49132472_A_C / 3_49126013_T_G 0.0017423458459882547 / 0.041025181157896495 0.0019625130257961386 / 0.002569958840604656 53 THRAP3_2 1_36288866_G_C / 1_36282396_ATTT_A 0.0020512788997300887 / 0.0016248690625818355 0.0001317384338547229 / 0.04220913139330165 54 CTNNA1_2 5_138932696_A_G / 5_138932714_T_G 0.002692413567981528 / 0.005472909098268261 0.007557173168109447 / 0.0016091365079487266 55 TAPT1_2 4_16162866_G_A / 4_16202603_GA_G 0.002918386893883101 / 0.000914379509289869 0.000763966557961968 / 0.0004886648390188492 56 SLC35F5_3 2_113717856_GA_G / 2_113742699_CA_C / 2_113723196_TA_T 0.003014076668232333 / 0.005012402765669162 / 0.0170410099009839 0.01701812431912492 / 6.159712513106605e-06 / 0.009792441988171948 57 CCAR1_3 10_68737016_C_A / 10_68747145_CT_C / 10_68760969_CT_C 0.00325467857819848 / 0.025692165325181263 / 0.0016743825966123902 0.003954046326130957 / 0.007417608363424872 / 0.007417608363424872 58 TADA1_2 1_166858437_T_C / 1_166869276_TA_T 0.003257661220538658 / 0.007643004397209361 0.012600985482671512 / 0.00358370659710894 59 SAFB_2 19_5668433_GT_G / 19_5653276_T_G 0.0039066263073592 / 0.0014480393694902619 0.0026106809691974946 / 0.018733735357902476 60 LEPROTL1_2 8_30105682_AT_A / 8_30156243_A_C 0.005708636597504029 / 0.014522072472209685 0.02256500634957293 / 3.3209275234199355e-06 61 SQSTM1_3 5_179833009_G_A / 5_179822433_T_C / 5_179832842_G_C 0.005980563650762417 / 9.139203270628232e-06 / 0.04751023288058377 0.03979973429187952 / 0.0024949336391905503 / 0.0024314650981475784 62 PLEC_10 8_143935900_T_G / 8_143916360_A_G / 8_143917054_T_G / 8_143918739_A_C / 8_143919099_A_G / 8_143975295_A_G / 8_143919088_C_G / 8_143925285_C_T / 8_143927138_G_A / 8_143 0.006797512530240399 / 0.023847093097519808 / 0.003689478164571844 / 0.04007075765894598 / 0.03700251313887589 / 0.004544202282444686 / 0.03720602259473315 / 0.00047050570860322235 / 4.768364655899894e-05 / 0.0001893462141118206 0.0004960012901022363 / 0.00910116635228719 / 0.025072704488480143 / 2.138708286444241e-05 / 0.0010288222361061275 / 0.039226625991533134 / 0.009415988048366521 / 0.005460087145469642 / 0.008162873576760793 / 0.001268625363946227 63 CTSA_2 20_45893486_C_CT / 20_45894873_G_C 0.006806775220314732 / 0.009189197205389115 0.0011092438036515453 / 2.1137755776974608e-05 64 RND3_2 2_150471770_GA_G / 2_150487464_GA_G 0.006850825677580675 / 0.002608896214858801 0.004413096667547799 / 0.009852344084866441 65 DOCK1_3 10_127409601_G_A / 10_127248143_T_C / 10_127248024_G_T 0.0069346786852210966 / 0.001954876992257982 / 0.00010052759289672492 0.021839153568346648 / 0.030500963727912844 / 0.020184142497530616 66 MYOF_2 10_93341723_C_T / 10_93379679_T_C 0.007420864833221702 / 0.007547951219247403 1.0154009952651607e-05 / 0.0006543495060757152 67 PDS5B_2 13_32758091_C_T / 13_32675925_C_A 0.0075589035603876795 / 0.0017607048342993868 0.0023301391981286807 / 0.004241708828197667 68 HEXB_3 5_74696784_G_A / 5_74715459_CT_C / 5_74715716_T_A 0.007745014587458687 / 4.786425040147315e-06 / 8.479985392616748e-06 0.037654298343869685 / 0.0009700644073606587 / 0.0006894634360309071 69 TANC1_2 2_159136061_C_T / 2_159174959_G_C 0.00802472531176929 / 0.006460757964179747 0.017357470848779515 / 0.02749828370491698 70 ASPH_2 8_61642872_G_A / 8_61638365_TA_T 0.009092096160092012 / 2.1941312888430133e-05 9.242250914202104e-05 / 0.0033421074285719613 71 GSN_2 9_121326794_T_G / 9_121318750_T_C 0.009209877230841344 / 0.005427091425517584 0.014858234163842209 / 0.01549301533305157 72 ZNF292_3 6_87258847_A_G / 6_87260583_C_G / 6_87257934_G_C 0.0095880085401273 / 0.002653056510702511 / 0.037301685006945806 0.03664575782437445 / 0.02762172574455939 / 1.3565314335396872e-05 73 DTNBP1_2 6_15662660_G_A / 6_15651411_GA_G 0.016540725603977957 / 0.0034858875216863218 0.005994085134454578 / 0.0014349866138238813 74 SUGP2_2 19_19025732_C_T / 19_19008374_A_C 0.023033529177264773 / 0.0007995182905667767 0.008182273259557721 / 0.003040780848236827 75 ARID1B_5 6_157084627_G_A / 6_157084796_G_A / 6_156935454_GT_G / 6_156779132_C_G / 6_157206255_A_C 0.023572130650620228 / 0.0065953837312734045 / 0.00024483625735866694 / 0.0017474661626312965 / 0.008386743713695547 0.002480449952777213 / 0.003319459056638543 / 0.031030935390966245 / 0.0436791475273224 / 0.02302848816217332 76 DAZAP1_3 19_1432575_T_C / 19_1432578_A_C / 19_1421326_T_G 0.025717426655995912 / 0.012380456372647609 / 0.005697517435006497 0.008783799588482919 / 0.004625103934387489 / 0.03399063425366008 77 FAM76B_2 11_95786079_T_C / 11_95787545_T_C 0.026712661661121014 / 0.007093482411673812 0.008842917440325095 / 0.006738523037696958 78 CNTRL_3 9_121175323_T_C / 9_121167492_C_T / 9_121123912_AT_A 0.02777922136116125 / 0.03429035595633583 / 0.009987376618823514 0.008182636643218607 / 0.0016137010941682265 / 0.04001035208622377 79 IQCB1_4 3_121788384_A_T / 3_121807190_T_G / 3_121781663_A_T / 3_121781662_C_A 0.02873631298848243 / 0.04311975747619515 / 0.0034541658078948746 / 0.0008249500332497977 0.0011523884052119758 / 0.0035712731344638405 / 0.03680371502100786 / 0.031208890653500118 80 RRBP1_2 20_17636886_T_C / 20_17643440_G_A 0.03507251839152679 / 0.01991260739356573 1.9056892828600246e-06 / 0.0037236305333221867 81 ZNF84_2 12_133048690_A_T / 12_133048009_C_G 0.037210990330289934 / 0.040160599243354515 0.0028259388562976405 / 0.008314464537214374 82 MYCBP2_2 13_77098982_T_G / 13_77061586_T_C 0.03744183774757608 / 0.00310540257860121 0.0038229074053839733 / 0.030373685856290068 83 CALD1_3 7_134933124_A_G / 7_134891710_CTT_C / 7_134941283_GAAA_G 1.0681523332046643e-06 / 0.0055155972985149685 / 0.0008159520917689481 0.034156156662500686 / 0.006749784168432884 / 0.007042501841739691 84 RBMX_5 X_136874303_G_C / X_136874308_C_T / X_136876571_C_A / X_136880660_G_A / X_136879426_ATG_A 5.449363562924237e-05 / 3.4887046700057416e-07 / 6.172396284131506e-05 / 0.0054727241117358974 / 0.005573036956662709 0.0383480406291467 / 0.029837740684056712 / 0.015245783387880662 / 0.03540981223032282 / 0.0056729536604581 85 POLR2B_3 4_57005538_CA_C / 4_57023798_AT_A / 4_57024870_CT_C 5.482928793734288e-06 / 0.02167722586394588 / 0.0009543180256774695 0.018564114826717992 / 0.007472844031288456 / 0.0012756499136273938 86 SECISBP2_3 9_89319872_A_G / 9_89325866_A_T / 9_89348180_T_G 6.195560569127674e-05 / 0.0006584940331716795 / 0.0021577193257759702 0.020014055406942226 / 0.00642217291639139 / 0.01739212501206905 87 FBXO41_2 2_73258961_C_G / 2_73264474_A_C 7.08184621839895e-05 / 0.008886058285019023 0.010646018841909207 / 0.014910469893708134 88 TSPAN4_2 11_844057_C_G / 11_865650_C_G 8.251559449584364e-05 / 0.0042898689776822594 0.04166717005266338 / 0.02401170518473186

On the other hand, Fig. 23 shows a method of manufacturing a test chip used for biomarker detection for the co-diagnosis of drugs for 6 cancer types summarized in [Table 1] and 6 drug types summarized in [Table 14]. It is done.

As shown in FIG. 23, in the first step, a diagnostic chip for each biomarker for the cancer type and drug type specified in [Table 1] and [Table 14] is produced, or the cancer type and drug type All the biomarkers for or all of them are made of one chip, and for the FRH marker associated with the drug type or cancer type from the patient, the illustrated example of FIG. 18 (EGFR pathway, one of the drug types of blood cancer) ) Using a set of FRHs that are highly related to drug reactions and total FRHs that are highly related to specific cancers, the drug reactivity can be predicted by generating a linear regression prediction model of FIG. 20. Accordingly, various cancer and cancer drug companion diagnostic chips can be manufactured and utilized as shown in FIG. 23 using FRH biomarkers specific to the six cancer types (CancerClass) and six drug types (DrugClass) summarized in this patent.

Finally, in summary for the biomarker composition for determining the reactivity to the IGFR drug, which is the subject of the present invention, each of the markers disclosed in Table 19 was found to be significant, and among these markers, markers related to SEPT6 gene expression X_119618658_T_G And the marker 1_16148437_A_C associated with EPHA2 gene expression was determined to be the major marker combination.

Of course, the biomarker composition according to the present invention may be configured by various combinations further including additional main biomarkers arranged in [Table 21].

List of additional significance markers related to IGFR drugs No. FRH Variants One VRK1_1 14_96853031_T_G 2 ACTR3_1 2_113934245_G_T 3 FOS_1 14_75280999_A_C 4 FCHO2_1 5_73082876_ATT_A 5 RAC1_1 7_6401802_T_G 6 CXCR5_1 11_118886492_C_G 7 KCNQ5_1 6_72622312_C_G 8 ACSS2_1 20_34920910_T_G 9 CRLF3_1 17_30792416_T_G 10 TSEN34_1 19_54192354_T_G 11 GTF2IRD1_1 7_74512993_A_G 12 CECR1_1 22_17188516_G_C 13 MAP4K1_1 19_38617327_T_G 14 PAPSS2_1 10_87727355_T_G 15 LAMC1_1 1_183131172_CAA_C 16 TBX21_1 17_47742656_A_C 17 PNRC2_1 1_23961703_G_C 18 HSPG2_1 1_21885485_A_C 19 CD72_1 9_35610848_A_C 20 KLF3_1 4_38689006_A_C 21 ZNRF3_1 22_29048501_A_C 22 ASAP2_1 2_9399979_T_G 23 CCDC69_1 5_151185396_T_C 24 EPS15_1 1_51472751_T_G 25 CBR1_1 21_36071267_G_C 26 CST3_1 20_23634133_A_C 27 IGF1R_1 15_98934682_T_G 28 MEI1_1 22_41699656_A_C 29 PTPN6_1 12_6946697_T_C 30 PMEPA1_1 20_57700062_A_G 31 WASL_1 7_123692324_GA_G 32 ARHGAP15_1 2_143228433_T_C 33 CLDN12_1 7_90413108_T_G 34 UACA_1 15_70669470_GA_G 35 TRIM2_1 4_153276097_A_G 36 RCC2_1 1_17413487_C_A 37 CD48_1 1_160711863_GA_G 38 GLCE_1 15_69261053_A_G 39 C21orf91_1 21_17793434_T_G 40 SIGLEC10_1 19_51417063_T_G 41 NCKAP1_1 2_182967372_CA_C 42 CD86_1 3_122103557_A_C 43 ERRFI1_1 1_8013331_A_G 44 PTPRC_1 1_198703381_A_C 45 CTDSPL_1 3_37957127_T_G 46 TAF4B_1 18_26286027_C_A 47 CDC42BPB_1 14_102939620_T_G 48 CTBP2_1 10_125026073_A_G 49 RASAL3_1 19_15458567_G_C 50 HLA-DOB_1 6_32813293_A_C 51 WAS_1 X_48691219_A_C 52 HBS1L_1 6_134965300_CA_C 53 FCRL5_1 1_157518564_T_C 54 UHRF2_1 9_6482002_G_T 55 SPR_1 2_72891611_A_C 56 DHX32_1 10_125867071_T_C 57 DAG1_1 3_49531399_T_G 58 RAVER2_1 1_64768580_T_G 59 KIAA0922_1 4_153635457_C_T 60 ITGAV_1 2_186637080_T_G 61 MSL3_1 X_11772199_A_C 62 LAPTM5_1 1_30733959_T_C 63 TPBG_1 6_82364929_T_C 64 CD52_1 1_26320120_TAA_T 65 APOBEC3G_1 22_39086265_G_T 66 ZNF107_1 7_64708051_G_A 67 PALLD_1 4_168691310_GT_G 68 WTAP_1 6_159753424_T_G 69 HCLS1_1 3_121634273_T_G 70 AVPI1_1 10_97677649_A_G 71 FAM129B_1 9_127578987_C_T 72 SH3RF1_1 4_169096709_G_A 73 DR1_1 1_93361899_T_A 74 CTTNBP2NL_1 1_112457049_C_A 75 PPP3CC_1 8_22539268_TC_T 76 WIPF1_1 2_174585550_T_G 77 RNGTT_1 6_88769645_C_T 78 CUEDC1_1 17_57873465_G_A 79 TMEM106A_2 17_43216747_A_C / 17_43216763_T_C 80 ARHGAP9_2 12_57474996_G_A / 12_57474460_G_A 81 ARHGAP25_3 2_68775067_A_G / 2_68818005_T_G / 2_68818023_T_G 82 LMNA_2 1_156134461_T_G / 1_156139242_AT_A 83 DAGLA_2 11_61734985_A_C / 11_61728297_A_C 84 NR2F6_2 19_17240636_T_G / 19_17232479_A_C 85 PLEKHA1_2 10_122406608_C_A / 10_122426897_T_G 86 APP_2 21_25881669_T_G / 21_25881706_A_T 87 ATP1B1_2 1_169127312_A_G / 1_169131404_A_C 88 IL10RA_2 11_117999603_A_C / 11_117999569_T_G 89 ERICH1_7 8_658279_A_G / 8_659132_C_G / 8_659777_T_G / 8_666991_A_G / 8_673593_G_A / 8_659879_A_C / 8_664843_G_C 90 ITGB5_4 3_124769064_T_G / 3_124809087_T_G / 3_124817591_T_G / 3_124859372_A_C 91 RFTN1_4 3_16357670_G_A / 3_16369972_C_G / 3_16433938_A_G / 3_16316966_A_C 92 RBFOX2_4 22_35759903_A_G / 22_35746471_A_C / 22_35761128_GA_G / 22_35745982_A_C 93 VSIG10_3 12_118095590_T_G / 12_118073908_T_G / 12_118095640_G_C 94 PLEKHG3_2 14_64741663_T_G / 14_64743474_T_G 95 ATP11A_7 13_112832759_A_G / 13_112871823_T_C / 13_112860417_A_C / 13_112810736_A_C / 13_112856140_A_C / 13_112832768_A_C / 13_112860332_A_C 96 RUNX3_2 1_24907301_T_G / 1_24907326_T_G 97 CTTN_3 11_70419876_A_C / 11_70419880_T_C / 11_70407283_C_T 98 CCDC28A_2 6_138785343_A_C / 6_138792859_T_C 99 CD63_3 12_55725557_A_C / 12_55725568_A_C / 12_55727027_A_C 100 SCARB2_2 4_76179751_A_C / 4_76179754_T_C 101 TJP1_4 15_29737354_A_C / 15_29761137_A_C / 15_29761418_A_C / 15_29718609_T_G 102 CD84_2 1_160549875_A_G / 1_160550877_C_G 103 IKZF1_3 7_50368194_A_C / 7_50382645_A_C / 7_50387420_G_C 104 LCP1_3 13_46143111_T_C / 13_46143326_T_G / 13_46143333_A_T 105 FAM177A1_2 14_35081207_T_C / 14_35081218_T_C 106 WDR91_2 7_135211631_T_C / 7_135187272_A_C 107 KLHL6_3 3_183492078_A_C / 3_183508233_G_T / 3_183508495_A_C 108 ZNF543_2 19_57329179_A_G / 19_57328339_A_C 109 PLEK_6 2_68380987_A_C / 2_68380990_A_C / 2_68386526_T_G / 2_68388306_A_G / 2_68388311_A_G / 2_68395610_G_T 110 KDM4C_2 9_6990364_G_T / 9_7103596_C_T 111 STAG3_6 7_100197862_A_C / 7_100197337_A_T / 7_100197348_T_C / 7_100201126_G_C / 7_100180467_A_G / 7_100202616_A_T 112 WDFY4_2 10_48733932_A_G / 10_48709976_C_T 113 PEX3_2 6_143462894_AT_A / 6_143468044_A_T 114 FERMT3_2 11_64207498_T_G / 11_64220073_T_G 115 ARHGAP5_3 14_32092970_T_C / 14_32154828_T_C / 14_32092963_G_C 116 NGLY1_3 3_25733762_T_C / 3_25736073_G_T / 3_25732334_A_C 117 NCKAP1L_3 12_54532103_A_T / 12_54509948_A_C / 12_54542688_G_C 118 DCK_2 4_71023692_C_A / 4_71022615_CTT_C 119 CNOT10_2 3_32705030_A_G / 3_32717271_G_A 120 ZNF430_2 19_21033730_G_A / 19_21022773_T_G 121 DIRC2_2 3_122795117_A_C / 3_122856322_A_G 122 DENND1C_2 19_6469618_A_C / 19_6466439_T_G 123 MRPL39_3 21_25592788_C_A / 21_25601549_G_T / 21_25599683_T_C 124 POLH_2 6_43587207_T_G / 6_43587205_A_G 125 LTBP3_4 11_65547976_T_G / 11_65547974_A_G / 11_65541348_A_C / 11_65543270_A_C 126 CCND1_2 11_69650913_A_G / 11_69643258_A_C 127 CTNNA1_4 5_138812304_T_G / 5_138933920_C_T / 5_138932696_A_G / 5_138812295_G_A 128 WDR7_2 18_56679573_T_G / 18_56781547_G_A 129 RCL1_5 9_4844704_T_C / 9_4844778_A_C / 9_4849647_T_C / 9_4860917_G_GT / 9_4860980_G_A 130 ZCCHC14_5 16_87414470_A_C / 16_87411666_T_C / 16_87412604_T_G / 16_87412609_T_G / 16_87407905_T_G 131 TOM1L1_3 17_54937096_G_T / 17_54937101_G_T / 17_54947274_A_C 132 SVIL_2 10_29532000_A_C / 10_29486218_G_T 133 TEAD4_2 12_3019250_C_T / 12_3022032_A_C 134 ARHGAP30_2 1_161052161_T_G / 1_161069551_T_G 135 FMNL1_3 17_45232440_T_G / 17_45238511_T_G / 17_45238503_C_G 136 CD151_3 11_836023_C_T / 11_836227_A_G / 11_835877_C_T 137 MBD2_2 18_54204938_G_A / 18_54224621_A_C 138 ACAP1_2 17_7350305_C_T / 17_7343627_T_G 139 RHPN2_4 19_33002924_G_A / 19_33044231_A_G / 19_33044540_A_C / 19_33011638_C_G 140 RASSF2_3 20_4797919_T_G / 20_4784304_T_C / 20_4784247_T_G 141 MYO1G_4 7_44965836_A_C / 7_44970706_A_C / 7_44964431_G_T / 7_44979051_A_C 142 PIK3CD_4 1_9720778_T_G / 1_9720785_A_G / 1_9719895_T_G / 1_9718938_A_G 143 PTGR1_2 9_111594107_A_G / 9_111578959_GAA_G 144 SH3D19_3 4_151122202_T_C / 4_151148202_G_T / 4_151175208_T_G 145 DTNBP1_2 6_15662698_A_G / 6_15662701_T_G 146 ZNRD1_3 6_30062280_G_A / 6_30062358_G_A / 6_30062412_T_A 147 SPATS2L_7 2_200329386_C_A / 2_200412288_CT_C / 2_200329511_A_C / 2_200412421_T_G / 2_200412425_T_G / 2_200477943_T_G / 2_200473083_GAA_G 148 ELOVL5_4 6_53295600_A_G / 6_53295602_T_G / 6_53291875_T_C / 6_53291854_T_G 149 AGER_6 6_32183680_C_G / 6_32183336_A_C / 6_32180626_G_C / 6_32182537_A_C / 6_32182532_A_C / 6_32180983_T_G 150 KLHL18_3 3_47319581_T_G / 3_47344095_C_A / 3_47319585_T_G 151 RBM6_6 3_50054242_G_T / 3_50054246_C_T / 3_50054250_C_T / 3_50054257_G_T / 3_50054263_T_G / 3_50066429_G_T

Here, FRH represents the expression gene, and the number added to FRH indicates the number of markers associated with each expression gene.

Explanation of terms

In the present invention, the definition of the drug type (DrugClass) is a type of drug targets and a functionally similar functional type of drug, or a gene group, drug pathway or drug signaling of a category in which the drug is affected. Pathway (drug signaling pathway), etc. are all termed as a generic drug type (DrugClass). FRH is a term for functionally related relative haplotype, eQTL is a term for expression quantitative trait loci for expression, and FRH (Exp | IC50) is over / under ) The term indicates the average value of IC50 for the expressed cluster, FRH (CNV | IC50) is the term indicating the average value of IC50 for the amplification / deletion cluster, and FRH (loci | IC50) is the given loci The term for the average value of IC50 for the type cluster, GDSC is the term for Genomics of Drug Sensitivity in Cancer, CCLP is the term for COSMIC Cell Lines Project, and the web page is http://cancer.sanger.ac.uk/cell_lines As can be seen from, CNV is a term for copy number variation, GBLscan is a term for Cancer Biomarker Labeling Scan, and ISCT stands for In Silico Clinical Trial. It is a term.

The rights of the present invention are not limited to the embodiments described above, but are defined by the claims, and those skilled in the art can make various modifications and adaptations within the scope of the claims. It is self-evident.

The present invention is a novel linear regression model that can reliably predict drug responsiveness by combining analysis of disease-specific specific gene mutation fingerprints including cancer and molecular pharmacological functional groups of drugs, drug indications and response prediction systems, and The method relates to GBLscan (Genetic Biomarker Scan), and according to the present invention, in the present invention, the degree of reactivity of the drug with a genome whose pharmacological effect is not known from the results of drug reactivity to the genome collected from in vitro and in vivo clinical trials There is an effect that can be predicted.

Claims (9)

In order to determine the responsiveness to the IGFR drug, in the biomarker composition consisting of a combination of markers containing mutations that regulate gene expression,
The biomarker composition,
Biomarker composition for IGFR drug reactivity determination, characterized in that it comprises a X_119618658_T_G (marker 1) and 1_16148437_A_C (marker 2).
According to claim 1,
The biomarker composition,
Biomarker composition for determining the IGFR drug responsiveness, characterized in that it further comprises any one or more of the markers listed in Table 21.
The method of claim 1 or 2,
The IGFR drug,
CSK1904529A, BMS-536924, BMS-754807 or Linsitinib, characterized in that it comprises any one or more biomarker composition for the determination of IGFR drug reactivity.
In order to determine the reactivity to the IGFR drug, in a method of determining a reactivity to the IGFR drug by detecting a biomarker composition composed of a combination of markers containing a mutation that modulates gene expression,
The biomarker composition,
X_119618658_T_G (marker 1) and 1_16148437_A_C (marker 2) IGFR drug reactivity determination method using a biomarker composition characterized in that it comprises a.
The method of claim 4,
The biomarker composition,
IGFR drug responsiveness determination method using a biomarker composition characterized in that it further comprises any one or more of the markers listed in Table 21.
The method of claim 4 or 5,
The IGFR drug,
CSK1904529A, BMS-536924, BMS-754807 or Linsitinib, IGFR drug reactivity determination method using a biomarker composition characterized in that it comprises any one or more.
In order to determine the responsiveness to the IGFR drug, in the diagnostic chip for detecting a biomarker composition consisting of a combination of markers containing mutations that regulate gene expression,
The detection target, the biomarker composition,
Diagnostic chip for biomarker composition detection for IGFR drug reactivity determination, characterized in that it comprises X_119618658_T_G (marker 1) and 1_16148437_A_C (marker 2).
The method of claim 7,
The biomarker composition,
Diagnostic chip for detecting a biomarker composition for IGFR drug reactivity determination, characterized in that it further comprises any one or more of the markers listed in Table 21.
The method of claim 7 or 8,
The IGFR drug,
CSK1904529A, BMS-536924, BMS-754807 or Linsitinib diagnostic chip for detecting biomarker composition for IGFR drug reactivity determination, characterized in that it contains any one or more.

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