KR20200014114A - A cosmetic composition comprising eutectic mixture - Google Patents

Abstract

A cosmetic composition according to the present invention comprises alpha hydroxy acid (AHA) in a form of a eutectic mixture, thereby being excellent in an exfoliation effect while causing less skin irritation, having a better skin penetration effect than AHA in a form of an aqueous solution, and having an excellent stabilizing effect and improved dispersibility of the eutectic mixture in a formulation by including hydrophobic powder.

Description

A cosmetic composition comprising eutectic mixture

The present invention relates to a cosmetic composition comprising a eutectic mixture, and more particularly to a cosmetic composition excellent in exfoliation effect while having less irritation by including alpha-hydroxy acid in the form of a eutectic mixture.

Alpha-hydroxy acid (AHA) is one of the commonly used ingredients to soften or remove hyperkeratinized skin layers. It promotes turnover of keratin, collagen synthesis and skin moisturization. It exhibits skin improvement effects such as reducing fine lines, treating and preventing acne (Non-Patent Document 1). Most AHAs have low pH and have excellent skin permeation and skin-improving effects, but due to low pH, it is difficult to use high contents due to severe skin irritation such as itching, tingling and burning, and various inflammatory stimuli such as erythema and edema. In addition, AHA has a disadvantage in that it is ionized when dissolved in water, thereby slowing skin absorption. In particular, when AHA is formulated in cosmetics, the pH of the formulation may be lowered, resulting in lower formulation stability and negative effects such as irritation to the skin. In order to compensate for this, increasing the pH of the formulation as a neutralizing agent has a problem in that the effect of AHA is lowered.

On the other hand, eutectic phenomenon is a melting point of the melting of two or more materials are mixed, each component contained in the mixture shows a solid state at room temperature, but when prepared as a mixture van der Waals interaction between each component Or anhydrous solution which is not crystallized due to hydrogen bonding and is present as a liquid at room temperature. Accordingly, when AHA is selected as one of the components included in the mixture, a liquid phase in which water is removed can be obtained. In the anhydrous state, since AHA is not ionized, it does not exhibit acid properties, so it is possible to use AHA with little irritation and is very advantageous for skin penetration because AHA is not charged.

However, there is a problem that such eutectic mixture does not exist stably in the cosmetic. When a protic solvent capable of hydrogen bonding is added to a composition comprising a eutectic mixture, the eutectic is caused by the solvent interacting with each of the components of the eutectic mixture (hydrogen bonds) to prevent bonding between the components of the eutectic mixture. It is difficult to maintain the properties of the mixture. In addition, anhydrous formulations are suitable for cosmetics including eutectic mixtures, but the specific gravity of most eutectic mixtures is greater than water, causing precipitation when mixed with oil, making it difficult to evenly disperse on low viscosity oils. Conventionally, hydrophilic powder was added to the composition to solve this problem. However, the eutectic mixture having hydrophilicity was adsorbed and agglomerated on the surface of the hydrophilic powder, thereby making it difficult to uniformly disperse it.

Accordingly, the present inventors have completed the present invention by researching and developing a cosmetic composition including AHA and improving stimulation problems and formulation stability due to low pH.

Korean Journal of Wellness Vol.10 No. 2, 2015, 161-169

The present inventors have studied to develop a cosmetic composition containing AHAs and improving the problems caused by low pH. As a result, the AHAs were added in the form of eutectic mixtures so that the AHAs in the eutectic mixtures exhibited the effects of AHAs without irritation in the skin and produced hydrophobic powders. Addition confirms that the eutectic mixture can be stably dispersed in the formulation and completes the present invention.

Accordingly, it is an object of the present invention to provide a cosmetic composition having excellent exfoliation effect but low irritation and excellent formulation stability, including AHA in the form of a eutectic mixture.

As a means for solving the above problems, the present invention

Eutectic mixtures comprising alpha-hydroxy acids; And it provides a cosmetic composition comprising a hydrophobic powder.

EMBODIMENT OF THE INVENTION Hereinafter, the structure of this invention is demonstrated in detail.

The cosmetic composition of the present invention comprises a eutectic mixture comprising alpha-hydroxy acid.

In the present invention, the alpha-hydroxy acid (AHA) refers to a compound in which an alcohol group or a hydroxyl group is added to the carbon at the α position of the carboxylic acid. By lowering the ion binding energy of keratinocytes to remove the keratin or promote the formation of new cells to shorten the cycle of keratinization process that is longer as the skin ages to promote the activity of skin cells to improve the skin. In addition, AHA promotes the production of collagen and elastin by fibroblasts to make the skin elastic and soft, and promotes skin moisturization by promoting the production of mucopolysaccharide, an important extracellular matrix component of the dermis. You can. AHAs help to remove the links between keratin in the stratum corneum by the action of acid, and soften the keratin. The AHA is lactic acid contained in capped milk or tomato juice, etc .; Citric acid contained in tangerines, oranges and the like; Malic acid contained in apples and the like; Tartaric acid in wine and the like; It may be one or more selected from the group consisting of glycolic acid (glycolic acid) and mandelic acid contained in sugar cane, but is not limited thereto.

In one embodiment, the AHA can be lactic acid. Since the lactic acid has a smaller molecular weight among the AHAs and thus has faster skin penetration, the lactic acid can quickly realize the effect of the desired AHAs.

In the present invention, the eutectic mixture means a mixture of two or more solid or liquid substances, and two compounds having a high melting point are mixed to form intermolecular hydrogen bonds to have a liquid state at room temperature. In the present invention, the eutectic mixture may be used interchangeably in terms of the same meaning as "eutectic solvent".

The AHA may be included in an amount of 10 to 95 parts by weight based on 100 parts by weight of the total weight of the eutectic mixture. Containing less than 10 parts by weight of the AHA may not exhibit the desired effect, and containing more than 95 parts by weight may cause a problem of irritation to the skin.

In the present invention, the eutectic mixture may be prepared by mixing with the components that can be bonded to the AHA by hydrogen bonding or van der Waals interaction. In this case, the AHA acts as a hydrogen bond donor (HBD), and the component bonded with the AHA may act as a hydrogen bond acceptor (HBA). Components that may be combined with AHA may include, but are not limited to, carbohydrates (sugars), polyols, carbonyl compounds, amino acids, carboxylic acids, or derivatives thereof. For example, the carbohydrate (sugar) includes monosaccharides such as glucose, galactose, or fructose; Disaccharides such as sucrose, lactose, maltose or trehalose; Polysaccharides such as low molecular weight dextrin, soluble starch, amylopectin or amylose; Or derivatives thereof. The polyol may include sorbitol, inositol, mannitol or polyvinylalcohol. Examples of the carbonyl compound include ketones; Or aldehydes such as dihydroxyacetone or erythrulose. The amino acids include alanine, cysteine, aspartic acid, glutamic acid, glutamic acid, phenylalanine, glycine, histidine, isoleucine, and lysine. lysine, leucine, methionine, asparagine, asparagine, pyrrolysine, proline, glutamine, arginine, serine, threonine, threonine, Selenocysteine, valine, tryptophan, tyrosine, or derivatives thereof, and derivatives thereof include trimethylglycine, known as betaine. It may include. Examples of the carboxylic acid include alpha-hydroxy acid (AHA), beta-hydroxy acid (BHA), polyhydroxy acid (PHA), and oxalic acid. acid, malonic acid, succinic acid, mercaptosuccinic acid, or glutaric acid.

In one embodiment, the component that forms a eutectic mixture by hydrogen bonding with AHA may be trimethylglycine (betaine).

The eutectic mixture according to the present invention can be prepared by selecting any method commonly used by those skilled in the art, and an exemplary method of preparing the eutectic mixture is as follows:

i) AHA and a method of hydrogenating the component having the lowest melting point of the hydrogen bonding to AHA to the temperature at which the component is melted to make a liquid phase, the remaining components are dissolved in the molten liquid and the mixture is cooled,

ii) AHA and a method of removing the solvent by lyophilization or an evaporator using a boiling point difference after dissolving the hydrogen bonding component with AHA in one solvent.

The solvent that can be used to prepare the eutectic mixture is not particularly limited as long as it is a solvent in which AHA and a component forming a hydrogen bond with AHA can be dissolved. Further, the solvent may be a non-solvent portion such as an auxiliary solvent such as water, alcohol, polyethylene glycol, ethyl caprylate, propylene glycol laurate, diethyl glycol monoethyl ether, tetraethylene glycol dimethyl ether and triethylene glycol monoethyl ether. May be used, but is not limited thereto.

The eutectic mixture according to the present invention can obtain a liquid phase in which water is removed by selecting one of the components as AHA. In the anhydrous state, AHA is not ionized and thus does not exhibit acid properties, so AHA can be used as a hypoallergenic, and since AHA is not charged, it can have a beneficial effect on skin penetration.

The eutectic mixture may be included as 0.0001 to 10 parts by weight, for example 0.001 to 8 parts by weight, 0.01 to 5 parts by weight, 0.1 to 3 parts by weight, 0.5 to 1 parts by weight relative to the total weight of the cosmetic composition.

However, the eutectic mixture as described above has a specific gravity greater than that of water, so when it is mixed with oil, precipitation occurs and it is difficult to evenly disperse the oil phase. In order to solve this problem, the powder was used to stably exist in the composition including the oil. However, when the powder has hydrophilicity, the eutectic mixture is difficult to be uniformly dispersed by being adsorbed and aggregated on the surface of the hydrophilic powder.

Thus, the cosmetic composition of the present invention contains a hydrophobic powder.

In the present invention, the hydrophobic powder may be included as a dispersion stabilizer for the eutectic mixture to be stably dispersed in the composition. As long as the hydrophobic powder is a powder having a hydrophobic property usable in a cosmetic composition, any of the hydrophobic powder may be used regardless of its shape (sphere, needle, plate), particle size (fine particles, pigment, etc.), and particle structure (porous chamber, nonporous, etc.). Can be used The hydrophobic powder may be a (meth) acrylic polymer, a lactone polymer, a polystyrene, a polyolefin polymer or a copolymer thereof or hydrophobic silica, but is not limited thereto. For example, the hydrophobic powder may be methyl methacrylate crosspolymer, H. di / trimethylolhexyllactone crosspolymer, polystyrene, hydrophobic silica, polyurethane, polyethylene, vinyldimethicone / methicylsesquioxane crosspolymer or diphenyldimeth Powders such as ticone / vinyldiphenyldimethicone / silsesquioxane crosspolymer can be used, but are not limited thereto.

In one embodiment, the hydrophobic powder may be methyl methacrylate crosspolymer, H. di / trimethylolhexyllactone crosspolymer or polystyrene.

In addition, the hydrophobic powder included in the cosmetic composition of the present invention may be one in which no pores are formed on the surface (non-porous), one having pores formed on the surface (porous), or hemispherical. In the present invention, the porous powder or hemispherical powder as described above has a large volume per weight, and thus has an excellent effect of improving dispersion in the formulation, and has an excellent oil absorption ability compared to non-porous, thereby increasing the viscosity of the oil, thereby making the eutectic mixture stable in the composition. An excellent effect can be obtained as a dispersion stabilizer for dispersion.

The powder may be included in an amount of 0.1 to 30 parts by weight, for example, 0.3 to 15 parts by weight, 0.5 to 10 parts by weight, and 1 to 5 parts by weight based on the total weight of the cosmetic composition.

The cosmetic composition according to the present invention may further include an oily component. The oily component is included in the composition to be present in the outer phase of the eutectic mixture to help the eutectic mixture to be stably present in the composition.

The oily component may include one or more of oils or waxes. The oils and waxes can be applied to all commonly used as ingredients of cosmetics in the art. For example, the oil may be silicone oil, ester oil, triglyceride oil, hydrocarbon oil, or vegetable oil, and may be used by combining one or more of these components as necessary.

For example, the silicone oil may be a silicone fluid oil or a silicone crosspolymer dispersed in oil. For example, the silicone fluid oils include cyclopentasiloxane, cyclohexasiloxane, cycloheptasiloxane, cyclomethicone, cyclophenylmethicone, cyclotetrasiloxane, cyclotrisiloxane, dimethicone, capryldimethicone, caprylyl tree Methicone, caprylylmethicone, cetearylmethicone, hexadecylmethicone, hexylmethicone, laurylmethicone, myristylmethicone, phenylmethicone, stearylmethicone, skaryldimethicone, trifluoropropyl Methicone, cetyldimethicone, diphenylsiloxyphenyltrimethicone, dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, methyltrimethicone or phenyltrimethicone can be used. The silicone oil components may be used alone or in combination of two or more oils. Silicone based crosspolymers may include, but are not limited to, dimethicone crosspolymers, dimethicone / vinyldimethicone crosspolymers, dimethicone PEG-10 / 15 crosspolymers or PEG-12 dimethicone / PPG-20 crosspolymers. .

As ester oils, ascorbyl palmitate, ascorbyl oleate, ascorbyl stearate, diisostearyl maleate, benzyl benzoate, benzyllaurate, butylene glycol dicaprylate / dicaprate, butylene glycol diisono Nanoate, butylene glycol laurate, butylene glycol stearate, butyl isostearate, cetealyl isononanoate, cetearyl nonanoate, cetyl caprylate, cetylethylhexanoate, cetyl isononano Eight, ethylhexyl caprylate / caprate, ethylhexyl isononanoate, ethylhexyl isostearate, ethyl hexyl laurate, hexyl laurate, octyldodecyl isostearate, isopropyl isostearate, iso Stearyl isononanoate, isostearyl isostearate, isocetylethylhexanoate, neopentylglycol dicaprate Neopentyl glycol diethyl hexanoate, neopentyl glycol diisononanoate, neopentyl glycol diisostearate, pentaerythritol stearate, pentaerythritol tetraethylhexanoate, dipentaerythritol hexaacid ester, Polyglyceryl-2 diisostearate, polyglyceryl-2 diisostearate, polyglyceryl-2 sesquiisostearate, polyglyceryl-2 isostearate, polyglyceryl-2 isostearate, poly Glyceryl-2 tetraisostearate, polyglyceryl-2 triisostearate, polyglyceryl-3 diisostearate, polyglyceryl-3 isostearate, polyglyceryl-4 diisostearate, polyglycerol Reel-4 isostearate, polyglyceryl-6 diisostearate, polyglyceryl-6 sesquiy butyrate or triethylhexanoin can be used. have.

Triglyceride oils include C8-C12 acid triglycerides, C12-C18 acid triglycerides, caprylic / capric / triglycerides, caprylic / capric / lauric triglycerides, C10-C40 isoalkyl acid triglycerides , C10-C18 triglycerides, glyceryltriacetylhydrostearate, soybeanglycerides, tribehenin, tricaprine, triethylhexanoin, triheptanoin, triisostearin, tripalmitin or tristearin can be used. .

As the hydrocarbon-based oil, liquid paraffin (liquid paraffin, mineral oil), paraffin, petrolatum, microcrystalline wax or squalene may be used.

Vegetable oils include avocado oil, wheat germ oil, rosehip oil, shea butter, almond oil, olive oil, macadamia oil, argan oil, meadowfoam oil, sunflower oil, castor oil, camellia oil, corn oil, safflower oil, soybean oil , Rape oil, macadamia nut oil, jojoba oil, palm oil, palm kernel oil or coconut oil may be used.

As the wax, all waxes such as hydrocarbon waxes, vegetable waxes or silicone waxes, which are generally used in cosmetics, can be used. For example, candela wax, carnauba wax, rice wax, bead wax, lanolin, ozokerite, ceresin wax, paraffin wax, microcrystalline wax, C30-C45 alkyldimethylsilylpolypropylsilsesquioxane, ethylene / Propylene copolymer or polyethylene wax may be included, but is not limited thereto.

The oil phase component is not particularly limited in content, it may be included in the remaining content except the above-described eutectic mixture and hydrophobic powder in the composition.

The cosmetic composition of the present invention may further include all kinds of ingredients usable in conventional cosmetics such as moisturizers, sunscreens, neutralizers, thickeners, perfumes, preservatives, antioxidants or pigments.

The cosmetic composition according to the present invention can be prepared in any formulation conventionally prepared in the art. For example, the cosmetic composition may include a lotion such as a flexible lotion or a nourishing lotion, an emulsion such as a spray type lotion, a facial lotion, a body lotion, a cream such as a nourishing cream, a moisture cream, an eye cream, a stick, an essence, an ointment, Formulations may include sprays, gels, packs, sunscreens, makeup bases, liquid types or foundations such as spray types, powders, cleansing lotions, makeup removers such as cleansing oils, cleansing foams, soaps, cleaners such as body washes, etc. However, the present invention is not limited thereto.

The cosmetic composition of the present invention may be used according to a conventional method of use, and the number of times of use may vary depending on the skin condition or taste of the user.

Advantages and features of the present invention and methods for achieving them will be apparent with reference to the experimental examples and preparation examples described below in detail. However, the present invention is not limited to the experimental examples and preparation examples disclosed below, but will be implemented in a variety of different forms, only to make the disclosure of the present invention complete, and having ordinary skill in the art It is provided to fully inform the person of the scope of the invention.

The cosmetic composition according to the present invention includes alpha-hydroxy acid (AHA) in the form of a eutectic mixture, has a low irritation and excellent exfoliation effect, and has excellent skin penetration effect as well as hydrophobicity as compared to aqueous solution AHA. The powder may be added to provide a cosmetic composition with improved dispersibility of the eutectic mixture in the formulation and excellent stabilizing effect.

1 is a result of observing the dispersion stabilization effect according to the form of the hydrophobic powder included in the formulation through the cut surface of the cosmetic.
2 is a graph comparing the degree of epidermal penetration of a cosmetic comprising lactic acid in the form of an aqueous solution and lactic acid in the form of an eutectic mixture.
Figure 3 is a graph comparing the degree of dermal penetration of the cosmetic comprising a lactic acid in the form of aqueous solution and lactic acid in the form of eutectic mixture.
Figure 4 is a graph comparing the exfoliation effect over time of the cosmetic containing lactic acid in the form of aqueous solution and lactic acid in the form of eutectic mixture.
Figure 5 is a graph comparing the degree of stimulation over time of the cosmetic comprising lactic acid in the form of an aqueous solution and lactate in the eutectic mixture.

Hereinafter, the present invention will be described in detail by the following examples. However, the following examples are merely to illustrate the invention, but the content of the present invention is not limited to the following examples.

Production Example . Lactic acid Eutectic  Preparation of the mixture

The lactic acid eutectic mixture was prepared by the following method.

i) a eutectic mixture of lactic acid and betaine was prepared. Specifically, lactic acid and betaine were prepared by mixing well so that the molar ratio is 2: 1 and then stirring at a constant rate at a temperature of 70 ° C. until it became a clear liquid.

ii) Lactic acid and betaine were mixed well so that the molar ratio was 2: 1, and then a small amount of water was added to dissolve to a completely transparent liquid, followed by lyophilization for at least 12 hours to remove moisture.

Example  1 to 5. Anhydrous Stick Formulation Cosmetics  Produce

Using the eutectic mixture prepared in the preparation example to prepare a cosmetic composition of the anhydrous stick formulation of Examples 1 to 3 according to the composition and content according to Table 1. Specifically, the oil phase component was warmed to a melting point or higher and sufficiently dissolved, and then hydrophobic powder was evenly dispersed in the solution. Thereafter, the eutectic mixture prepared in Preparation Example was added to the solution, dispersed, and cooled to prepare a cosmetic of anhydrous stick formulation. At this time, the methyl methacrylate crosspolymer was used as a hydrophobic powder for each type, and as a comparative example, a cosmetic was prepared without the hydrophobic powder (Comparative Example 1).

Raw material name (content: Parts by weight ) Comparative example  One Example  One Example  2 Example  3 Ceresin 15.00 15.00 15.00 15.00 Synthetic wax 6.40 6.40 6.40 6.40 Ethylene / Propylene Copolymer 1.60 1.60 1.60 1.60 C30-45 Alkyldimethylsilylpolypropylsilsesquioxane 5.00 5.00 5.00 5.00 Butylene Glycol Dicaprylate / Dicaprate 22.00 22.00 22.00 22.00 Triethylhexanoin 23.50 20.50 20.50 20.50 Diphenylsiloxyphenyltrimethicone 14.00 14.00 14.00 14.00 1,2-hexanediol 2.00 2.00 2.00 2.00 Dimethicone, Dimethicone / Vinyl Dimethicone Crosspolymer 5.00 5.00 5.00 5.00 Caprylyl Methicone, Fiji-12 Dimethicone / Fiji-20 Crosspolymer 5.00 5.00 5.00 5.00 Lactic Acid Eutectic Mixtures 0.50 0.50 0.50 0.50 Methyl methacrylate crosspolymer (nonporous) - 3.00 - Methyl methacrylate crosspolymer (porous) - - 3.00 - Methyl Methacrylate Crosspolymer (Hemispherical) - - - 3.00 total 100 100 100 100

In addition, the cosmetics of the anhydrous stick formulations of Examples 4 and 5 were prepared using H. di / trimethylolhexyllactone crosspolymer and polystyrene as hydrophobic powders. Specific manufacturing method was carried out in the same manner except in Examples 1 to 3 and the kind of hydrophobic powder.

Raw material name (content: Parts by weight ) Example  4 Example  5 Ceresin 15.00 15.00 Synthetic wax 6.40 6.40 Ethylene / Propylene Copolymer 1.60 1.60 C30-45 Alkyldimethylsilylpolypropylsilsesquioxane 5.00 5.00 Butylene Glycol Dicaprylate / Dicaprate 22.00 22.00 Triethylhexanoin 20.50 20.50 Diphenylsiloxyphenyltrimethicone 14.00 14.00 1,2-hexanediol 2.00 2.00 Dimethicone, Dimethicone / Vinyl Dimethicone Crosspolymer 5.00 5.00 Caprylyl Methicone, Fiji-12 Dimethicone / Fiji-20 Crosspolymer 5.00 5.00 Lactic Acid Eutectic Mixtures 0.50 0.50 H / D trimethylolhexyllactone crosspolymer 3.00 - polystyrene - 3.00 total 100 100

Experimental Example  1. Dispersion stabilization effect

One) Of methyl methacrylate crosspolymer  Confirmation of dispersion stabilization by shape

In order to visually confirm the precipitation phenomenon according to the form of the powder of the cosmetics of Examples 1 to 3 by dissolving the water-soluble pigment (yellow No. 4) in the eutectic mixture was carried out experiment. After the preparation of the stick formulation, the bottom and the cut surface were first confirmed the effect of improving dispersion, the formulation was re-heated and cooled, and then the precipitation phenomenon was confirmed by confirming the dispersion stabilization effect secondarily.

[Criteria for evaluating dispersion improvement and dispersion stabilization effect]

◎ very effective

○: excellent effect

△: weak improvement effect

Χ no improvement

As a result, as can be seen from the bottom surface and the cut surface of the stick formulation of Table 3, Comparative Example 1, which does not contain the hydrophobic powder, it can be confirmed that the pigment is submerged and the hydrophobic powder is unevenly distributed. On the other hand, in the case of Examples 1 to 3 to which the hydrophobic powder (PMMA) was added, it was confirmed that the formulation was uniform in color and the eutectic mixture was evenly distributed. In particular, it was confirmed that the dispersion stabilization effect is the best in Example 3 including the hemispherical PMMA (Fig. 1).

2) Hydrophobicity other than PMMA In powder  Confirmation of dispersion stabilization effect

In the same manner as in 1), the dispersion stabilization effect of the cosmetics of Examples 4 and 5 was confirmed. The same evaluation criteria as in 1) were applied to the dispersion improvement and dispersion stabilization effects.

As shown in Table 4, it was confirmed that the pigment is evenly distributed and the eutectic mixture is uniformly dispersed in Example 4 and H5 using polystyrene as a hydrophobic powder. The results confirmed that the dispersion improvement and dispersion stabilization effects were excellent even in hydrophobic powders other than PMMA.

Example  6. Anhydrous Cream Formulation Cosmetics  Produce

To the cosmetic composition of the dry cream formulation according to the composition and content of Table 5 below. The cosmetic of the anhydrous cream formulation was prepared in the same manner as in Examples 1 to 5. At this time, Comparative Example 2 was prepared in the same manner as in Example 6 except that the lactic acid was dissolved in an aqueous solution.

Raw material name (content: Parts by weight ) Comparative example  2 Example  6 Caprylic / Capric Triglyceride 26 26 Triethylhexanoin 54.99 54.99 Caprylyl Methicone, Fiji-12 Dimethicone / Fiji-20 Crosspolymer 5 5 Dimethicone, Dimethicone / Pig-10 / 15 Crosspolymer 5 5 Rhodamine b 0.01 0.01 PMMA 3 3 Dextrin palmitate / ethylhexanoate 5 5 Lactic acid solution 1.00 - Lactic acid Eutectic  mixture - 1.00 total 100 100

Experimental Example  2. Check the skin penetration effect

After applying the cosmetic composition of the anhydrous cream formulation prepared in Example 6 to the pig skin, the fluorescent substance permeated to the epidermis and dermis was quantified to compare the skin permeability of lactic acid by time (4 hours and 8 hours) relative to FIGS. 3 is shown.

As shown in FIGS. 2 and 3, the permeability to the epidermis was about 1.1 times the skin permeability increased with time in the case of Comparative Example 2 in which lactic acid was added in the form of an aqueous solution, whereas lactic acid was added in the form of a eutectic mixture. 6 was found to be about 1.3 times more permeable at 4 hours compared to Comparative Example 2 and about 1.9 times more at 8 hours. Skin permeability with time of Example 6 increased about 2.3 times compared to Comparative Example 2 after 8 hours (Fig. 2).

In the case of the dermis, 4 hours after application of Comparative Example 2 and Example 6 did not show a significant difference in the skin permeability, but Example 8 at 8 hours conditions was about 1.85 times more permeate showed a big difference. Skin permeability with time of Example 6 increased about 1.5 times compared to Comparative Example 2 after 8 hours (Fig. 3).

Example  7. Anhydrous Stick Formulation Cosmetics  Produce

In the same manner as in Examples 1 to 5, to prepare a cosmetic of the anhydrous stick formulation in the composition of Table 6 below. At this time, Comparative Example 3 was prepared in the same manner as in Comparative Example 7, except that the lactic acid was dissolved in an aqueous solution.

Raw material name (content: Parts by weight ) Comparative example  3 Example  7 Ceresin 15.00 15.00 Synthetic wax 6.00 6.00 Ethylene / Propylene Copolymer 1.50 1.50 C30-45 alkyldimethylsilylpolypropylsilsesquioxane 4.00 4.00 Butylene Glycol Dicaprylate / Dicaprate 20.00 20.00 Triethylhexanoin 17.60 18.10 Green Wattle / Jojoba / Sunflower Seed Wax Polyglyceryl-3 Ester 1.90 1.90 Diphenylsiloxyphenyltrimethicone 14.00 14.00 1,2-hexanediol 2.00 2.00 Dimethicone 3.75 3.75 Dimethicone / Vinyl Dimethicone Crosspolymer 1.25 1.25 Cetyl Fiji / Fiji-10/1 dimethicone 1.00 1.00 Caprylylmethicone, Fiji-12Dimethicone / Fiji-20 Crosspolymer 5.00 5.00 Methyl Methacrylate Crosspolymer 3.00 3.00 Polymethylsilsesquioxane 1.80 1.80 H-Dimethyl / trimethylolhexyllactone crosspolymer 1.20 1.20 Lactic acid solution 1.00 - Lactic acid Eutectic  mixture - 0.50 total 100 100

Experimental Example  3. Check the exfoliation effect and degree of stimulation

In order to confirm the exfoliation effect and the degree of stimulation according to the form of lactic acid, 5% of DHA (dihydroxy acetone) solution was stained on the inner region of the upper arm (diameter 2 cm) of the test subject (n = 4). Thereafter, a stick formulation containing lactic acid (1%) in the form of an aqueous solution (Comparative Example 3) and lactic acid in the form of an eutectic mixture (0.5%) (Example 7) was rubbed and applied twice or more twice a day for two weeks. Then, the L value (brightness value) change was measured with the chromameter. The untreated group was used as a negative control at this time. The questionnaire was queried on a 5-point scale, and the degree of redness was visually checked to evaluate the degree of stimulation. The exfoliation effect was calculated by the following general formula and shown in the graph.

[general meal]

In the above general formula, L _max is the L value immediately after coloring with DHA; L _d is the L value for each date; L ₀ means the initial L value before coloring with DHA.

As shown in Figure 4, in the case of the cosmetic of Example 7, it can be seen that as time passes, the exfoliation effect is significantly superior to the untreated group and the cosmetic of Comparative Example 3. In addition, lactic acid (Example 7) in the form of eutectic mixture was excellent in exfoliation effect but the lowest irritation (Fig. 5). That is, lactic acid in the form of eutectic mixtures showed a better effect (about 1.3 times on the 13th day) at low concentration at half the concentration of the aqueous solution.

Claims (10)

Eutectic mixtures comprising alpha-hydroxy acids (AHA); And a hydrophobic powder. The method of claim 1,
The alpha-hydroxy acid is at least one selected from the group consisting of lactic acid, citric acid, citric acid, malic acid, tartaric acid, mandelic acid, and glycolic acid. Cosmetic composition. The method of claim 1,
The eutectic mixture is a cosmetic composition comprising an alpha-hydroxy acid and at least one component selected from the group consisting of carbohydrates, polyols, carbonyl compounds, amino acids, carboxylic acids and derivatives thereof. The method of claim 1,
The alpha-hydroxy acid is 10 to 95 parts by weight based on 100 parts by weight of the total eutectic mixture. The method of claim 1,
The eutectic mixture is 0.0001 parts by weight to 10 parts by weight based on the total weight of the composition. The method of claim 1,
The hydrophobic powder may be a (meth) acrylic polymer, a lactone polymer, a polystyrene, a polyolefin polymer or a copolymer thereof; And at least one cosmetic composition selected from the group consisting of hydrophobic silica. The method of claim 1,
The hydrophobic powder is a cosmetic composition having pores formed on the surface or hemispherical (hemispherical) form. The method of claim 1,
The cosmetic composition further comprises an oily component. The method of claim 8,
The cosmetic composition is a cosmetic composition comprising the eutectic mixture as an inner phase and the oil phase component as a trauma. The method of claim 1,
The cosmetic composition is a cosmetic composition of anhydrous formulation.

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