KR20190131670A - Implantable photodynamic therapy device - Google Patents

Abstract

The present invention relates to a photodynamic treatment device inserted into a body, and more specifically, to a photodynamic treatment device inserted into a body, which is inserted into a body of a patient and not restricted by time until removed in surgical performance, has a light source inserted into a body, which can be inserted into several lesions, thereby solving a problem of a limited number of lesions to be subjected to surgery, and has a structure of being separated from an endoscope probe and then inserted into a lesion, thereby solving a problem of low light transmission rate caused by the probe and breaking of the probe. According to the present invention, the photodynamic treatment device inserted into a body has a structure of being driven by a thin-film battery, a biofuel battery, and a wireless power transmission hybrid power supply module such that power consumption per a unit area can be increased in a short time to enhance efficiency of light emission; power can be smoothly supplied to allow continuous treatment for a long time; a biocompatible transparent silicon cover is used to protect the device from moisture in vivo and prevent toxic materials constituting the device from being exposed to the inside of the body.

Description

Implantable photodynamic therapy device

The present invention relates to an implantable photodynamic therapy device in the body, and more particularly, without limitation of the procedure time until removal into the implantable body, the implantable light source can be inserted into various lesions to solve the problem of limitation of the procedure variable. In addition, the present invention relates to an implantable photodynamic therapy apparatus capable of solving a problem of degradation of light transmission and breakage of a probe by applying a structure that is separated from an endoscope probe and inserted into a lesion.

Cancer is the number one cause of death in most developed countries, including Korea, and is one of the most important diseases that humanity must overcome. In addition to the three main treatments for cancer treatment, such as surgery, chemotherapy, and radiation therapy, photodynamic therapy (PDT), along with immunotherapy and gene therapy, is also developing as another method for the treatment of various cancers. .

Photodynamic therapy (PDT) is a technology that treats incurable diseases such as cancer without surgery by using photosensitizer, and the photosensitizer produces a chemical reaction caused by light and oxygen. Free radicals are the next generation of therapies that selectively destroy only cancer cells without pain for the patient.

Such photodynamic therapy has been actively researched in the early 20th century, and is currently being used to increase immunity in the diagnosis and treatment of cancer, autologous bone marrow transplantation, antibiotics, AIDS treatment, skin transplant surgery, and arthritis. Its application range is gradually expanding.

In particular, photodynamic therapy used in the treatment of cancer irradiates light with a photosensitive agent, thereby changing oxygen molecules into free radicals, generating new radicals or creating new chemical species to selectively kill only those cells.

As a peripheral technology of such photodynamic therapy, it can be found in Korean Patent Application Publication No. 10-2013-0011162 or Korean Patent Application Publication No. 10-2013-0008575. As a photosensitive agent, porphyrin derivatives, chlorin, Bacteriochlorin, phthalocyanine, and the like are known.

Despite the many advantages of photodynamic therapy, the first generation of photosensitizers exhibits photosensitivity for four to six weeks, during which time the patient must avoid direct sunlight, with tumor cell penetration depths of up to 4-6 mm. Although only cancer can be treated, the second-generation sensitizers (Radachlorin, Npe6; Photolon, chlorin e6) are photosensitive, which is only about two days, which makes them much more convenient than the first generation. There is this.

Recently, a hospital has been successfully applied to the treatment of deep tissues (biliary and pancreas) through ultrasound endoscopy photodynamic therapy using a laser probe. However, the possibility of targeted photodynamic therapy for deep malignancies has been suggested. In the case of epidemiological treatment, procedure complications and repetitive procedures are difficult for about 30 minutes, and only one lesion per procedure can be performed.

In addition, the conventional optical shear probe inserted into the endoscope has a high light transmission loss rate according to the length, the hardness of the probe itself is high, the crack in the probe during the procedure is often cracked or broken during the procedure, the light in the abdominal cavity requiring a high bending rate There are many problems with epidemiology.

Republic of Korea Patent Publication No. 10-2013-0011162 Republic of Korea Patent Publication No. 10-2013-0008575

The present invention is to solve the conventional problems as described above, without being limited to the procedure time until removal in the implantable body, it is possible to solve the problem of limiting the procedure parameters by inserting the implantable light source into various lesions, endoscope It is an object of the present invention to provide an implantable photodynamic therapy apparatus that can solve the problem of lowering the light transmission rate and breakage of the probe by applying a structure separated from the probe and inserted into the lesion.

In addition, the present invention can be combined treatment to resolve the side effects of conventional chemotherapy and radiotherapy for the treatment of existing malignant tumors, and to reduce the extent of the tumor before proceeding to the resection surgery, and to be resected to a minimum as necessary In addition, it is another object of the present invention to increase the light irradiation efficiency with a high power consumption per unit area within a short time by using a micro LED, and to provide an intrabody implantable photodynamic therapy device with a smooth power supply so as to be sustainable for a long time as an implantable body.

Intra-body implantable photodynamic therapy apparatus according to the present invention for achieving the above object is a tube-type biofuel cell unit that is inserted into one side fixed to the lesion site of the body, and generates power using the fuel in the body; A light irradiation unit coupled to the biofuel cell unit and irradiating light to a lesion site in the body using power generated from the biofuel cell unit to activate a photosensitive agent injected into the body; And a cover part formed of a transparent material to surround the light irradiation part to protect the light irradiation part from moisture and body fluid in the body, and to transmit light emitted from the light irradiation part.

The light irradiation unit is a mounting plate coupled to the other end of the biofuel cell unit, a thin film type battery unit installed on the mounting plate to store the power generated by the biofuel cell unit, and disposed above the battery unit And a controller including a light emitting module for irradiating light, a substrate installed on one surface of the battery unit, a controller mounted on the substrate and controlling charge and discharge of the battery unit and operation of the light emitting module; It is provided on the substrate characterized in that it comprises a wireless power receiving unit for receiving the wireless power signal transmitted from the wireless power transmission unit to convert the power.

The biofuel cell unit and the cover unit is characterized in that formed in a diameter within 1.5cm to be inserted into the laparoscopic for peritoneal cancer.

The light irradiation unit is a mounting plate coupled to the other end of the biofuel battery unit, a substrate is installed on one side is installed in the center of the mounting plate and the other side away from the mounting plate, and is mounted on the substrate A control unit including a light emitting module including a plurality of LEDs, a controller provided on the substrate to control an operation of the light emitting module, and a work is installed at an edge of the mounting plate and the other side extends away from the mounting plate. And a wireless power receiver provided on an outer circumferential surface of the support and receiving a wireless power signal transmitted from the wireless power transmitter and converting the power into a power.

The biofuel cell unit and the cover unit is characterized in that formed in a diameter within 1mm to be inserted into the ultrasonic endoscope for digestive cancer.

The biofuel cell part inserted into the lesion part of the body is characterized in that it further comprises an anchoring part connected to the biofuel cell part and the other side is fixed to the lesion part to prevent the biofuel cell part is drawn out from the lesion part.

Intra-body implantable photodynamic therapy apparatus according to the present invention is applied to most malignant tumors (solid cancer) and can be used in parallel or sequentially with existing surgery, anticancer, and radiation therapy, thereby maximizing a therapeutic effect.

In addition, the implantable photodynamic therapy apparatus according to the present invention can increase the power consumption per unit area within a short time to increase the light irradiation efficiency by applying a structure driven by a thin film battery, a biofuel cell, a wireless power transmission hybrid power supply module. In addition, the power supply is smooth, the long-term continuous treatment is an advantage.

In addition, the implantable photodynamic therapy apparatus according to the present invention has the advantage of protecting the device from moisture in the body by applying a biocompatible transparent silicone cover and protecting the toxic substance of the material constituting the device from being exposed to the body.

In addition, the implantable photodynamic therapy apparatus according to the present invention has an advantage of being able to be inserted into the body using a laparoscope and an ultrasound endoscope by having a diameter within 1.5 cm for peritoneal cancer and a diameter within 1 mm for gastrointestinal cancer.

1 is a perspective view of an implantable photodynamic therapy apparatus according to a first embodiment of the present invention.
Figure 2 is an exploded perspective view of the implantable photodynamic therapy apparatus according to the first embodiment of the present invention shown in FIG.
Figure 3 is a perspective view of the implantable photodynamic therapy apparatus according to the second embodiment of the present invention.
Figure 4 is a perspective view of the implantable photodynamic therapy device according to a second embodiment of the present invention.

Hereinafter, an implantable photodynamic therapy apparatus according to a preferred embodiment of the present invention will be described in detail with reference to the accompanying drawings.

1 and 2 illustrate an implantable photodynamic therapy apparatus 1 according to a first embodiment of the present invention. 1 and 2, the body-insertable photodynamic therapy apparatus 1 according to the first embodiment of the present invention is inserted into the laparoscope and inserted into the abdominal cavity, and is fixed to the lesion site of the abdominal cavity to provide light to the lesion site As a treatment for the lesion site by irradiating, the biofuel cell unit 100, the light irradiation unit 200, and the cover unit 300 is provided.

The biofuel cell unit 110 has one side inserted into and fixed to a diseased area where cancer or a tumor develops in the body, and generates power using fuel (glucose) in the body, and the battery unit 110 and the tube. It is configured to include a member 120.

The battery unit 110 generates power by glucose in a living body, and is formed to be wound in a spiral shape. In the center, the battery unit 110 includes a light irradiation unit 200 or a battery unit 220 which describes power generated by the battery unit 110. When the lead wire 130 for transmission is connected, and directly supply the generated power to the light irradiation unit 200 When the lead wire 130 is connected to the light emitting module 230, and supplies the generated power to the battery unit 220 The lead wire 130 is connected to the battery unit 220. Since a specific power generation mechanism of the battery unit 110 is a known structure, detailed description thereof will be omitted.

The tube member 120 is formed to surround the outside of the battery unit 110, made of gold or titanium for biocompatibility, and the tube is formed in the hollow along the longitudinal direction to accommodate the battery unit 110 inside It is formed in a shape, a plurality of through-holes 121 are formed in the outer peripheral surface so that the glucose in the body can contact the outer peripheral surface of the battery unit 110.

In addition, the body-insertable photodynamic therapy apparatus 1 according to the present invention has one side of the biofuel battery unit 100 to prevent the biofuel battery unit 100 inserted into the lesion site in the body from being drawn out from the lesion site and detached from the lesion site. ) And the other side may further include an anchoring portion (not shown) fixed to the lesion site. The anchoring part may be configured to include a wire fixed at one end to the tube member 120 and the other end to a predetermined length, and an anchor member fixed to an end of the wire and inserted into and fixed at the lesion site.

The light irradiation unit 200 is coupled to one side of the biofuel cell unit 100, and uses the power generated from the biofuel cell unit 100 to activate the photosensitive agent injected into the body to light the lesion site in the body. In order to irradiate, it comprises a mounting plate 210, a thin film type battery unit 220, a light emitting module 230, a control unit 240, and a wireless power receiver 250.

The mounting plate 210 is formed on a disc and is fixed to the end of the tube member 120 to close the end side of the tube member 120.

The battery unit 220 is installed on one surface of the mounting plate 210 and stores the power generated by the biofuel battery unit 100 and stores the power received by the wireless power receiver 250 described later.

The battery unit 220 is formed in a thin coin-shaped or thin film type, the bottom and the upper surface is provided with a charging terminal unit 221 for receiving the power generated from the biofuel battery unit 100, respectively, the peripheral side peripheral surface Discharge terminals 222 for supplying power to the light emitting module 230 to be described later are provided to protrude.

The light emitting module 230 is disposed above the battery unit 220 to irradiate light, and one end of the light emitting module 230 is fixed to the mounting plate 210 and the other side of the light emitting module 230 extends to the upper part of the battery unit 220. Dome-shaped support portion 231 formed to surround the upper portion, the flexible PCB 232 disposed in close contact with the outer peripheral surface of the support portion 231, coupled to the flexible PCB 232 for activating or exciting the photosensitive agent A plurality of LEDs 233 for emitting light in the wavelength band is provided.

The LED 233 of the light emitting module 230 may be applied to emit light of 630nm, 660nm wavelength, it can be changed in various ways depending on the type of light sensitizer.

The control unit 240 may charge the battery unit 220 and supply the power stored in the battery unit 220 to the light emitting module 230 so that the power generated in the biofuel cell unit 100 is stored in the battery unit 220. Control the discharge of the battery unit 220 so as to control the operation of the light emitting module 230.

The controller 240 may include a substrate 241 installed on one surface of the battery unit 220 and a controller mounted on the substrate 241 and controlling the operation of the charge / discharge and light emitting module 230 of the battery unit 220 ( 242).

The wireless power receiver 250 is provided in a planar shape on the substrate 241 around the controller 242, and receives and converts the wireless power signal transmitted from an external wireless power transmitter (not shown) to power.

The cover part 300 is formed in a dome shape or a circular shape or a bulb shape that surrounds the light irradiation part 200 to protect the light irradiation part 200 from moisture and body fluid in the body, and the light emitted from the light emitting module 230 transmits the lesion. It is formed of a transparent material to reach the site.

Intra-body implantable photodynamic therapy apparatus 1 according to the first embodiment of the present invention can be inserted into the body and inserted into a lesion by using a laparoscope after insertion into a laparoscope for peritoneal cancer used for diagnosis and treatment of peritoneal cancer. The biofuel cell unit 100 and the cover unit 300 are formed to a diameter within 1.5 cm so as to be.

The implantable photodynamic therapy device 1 according to the first embodiment of the present invention as described above is applied to most malignant tumors (solid cancer) and can be used in parallel or sequentially with existing surgery, chemo, and radiation therapy. There is an advantage that can maximize the therapeutic effect.

In addition, the implantable photodynamic therapy apparatus 1 according to the first embodiment of the present invention applies a structure driven by a thin-film battery, a biofuel cell, and a wireless power transmission hybrid power supply module to reduce power consumption per unit area within a short time. It can increase the light irradiation efficiency, and the power supply is smooth, there is an advantage that long-term continuous treatment.

In addition, the implantable photodynamic therapy apparatus 1 according to the first embodiment of the present invention applies a biocompatible transparent silicone cover to protect the device from moisture in the body and exposes the toxic substance of the material constituting the device to the body. There is an advantage to protect against.

In addition, the implantable photodynamic therapy apparatus 1 according to the first embodiment of the present invention has an advantage of being able to be inserted into the body by using a laparoscope through a minimal excision by having a diameter within 1.5 cm for peritoneal cancer.

On the other hand, Figures and Figures 2 shows the implantable photodynamic therapy device 2 according to the second embodiment of the present invention. Referring to Figures and Figures, the implantable photodynamic therapy apparatus 2 according to the second embodiment of the present invention is inserted into the body is inserted into the ultrasound probe for the diagnosis and treatment of gastrointestinal cancer is inserted into the body, the lesion site of the digestive organs It is fixed and irradiated with light to the lesion site to treat the lesion site, the biofuel cell unit 100, the light irradiation unit 200A and the cover unit 300A is provided.

The biofuel cell unit 100 applies the same structure as that described in the implantable photodynamic therapy apparatus 1 according to the first embodiment of the present invention described with reference to FIGS. 1 and 2.

The light irradiation unit 200A includes a mounting plate 210A, a light emitting module 230A, a control unit 240A, a support 250A, and a wireless power receiver 260A.

The mounting plate is coupled to the other end of the biofuel cell unit 100 and is formed on a flat plate. The mounting plate is provided with a pair of support brackets spaced at intervals corresponding to the width of the substrate so as to be fitted to each side of the width direction of the substrate of the light emitting module to be described later.

The light emitting module 230A includes a substrate 220A extending at a center of the mounting plate 210A and the other side extending away from the mounting plate 210A, and a plurality of LEDs 233 mounted on the substrate 220A. ).

The substrate is inserted into the support bracket provided in the mounting plate and supported by the mounting plate. The portion where the controller is installed is relatively wide, and the portion where the LED is installed is narrowly formed.

The controller is provided on the substrate 220A and includes a controller 242 for controlling the operation of the light emitting module 230A.

The support is installed on the edge of the mounting plate 210A, the other side is extended away from the mounting plate 210A, it is formed in a cylindrical shape cut one side.

The wireless power receiver is provided on the outer circumferential surface of the support 250A and receives the wireless power signal transmitted from the wireless power transmitter to convert the power into power. Both ends of the wireless power receiver are bent and coupled to the cut-out portion of the support.

The cover part 300A surrounds the light irradiation part 200A to protect the light irradiation part 200A from moisture and body fluid in the body, and is formed in a cylindrical structure having an outer diameter corresponding to the outer diameter of the support 250A, but has an end portion rounded. . In addition, the cover part 300A is formed of a transparent material so that the light emitted from the light emitting module 230A can pass and reach the lesion site.

In addition, the body-insertable photodynamic therapy apparatus 2 according to the second embodiment of the present invention has one side living body to prevent the biofuel battery unit 100 inserted into the lesion site in the body from being drawn out from the lesion site and detached from the lesion site. The other side may further include an anchoring part connected to the fuel cell part 100 and fixed to the lesion part.

The implantable photodynamic therapy apparatus 2 according to the second embodiment of the present invention is inserted into an ultrasound endoscope used for diagnosis and treatment of gastrointestinal cancer, and then inserted into the body and fixed to an lesion site using an ultrasound endoscope. It is preferable that the biofuel cell unit 100 and the cover unit 300A are formed to a diameter within 1 mm.

The implantable photodynamic therapy apparatus 2 according to the second embodiment of the present invention as described above can be used in parallel or sequentially with existing surgery, anticancer, and radiation therapy, so that the therapeutic effect can be maximized. have.

In addition, the implantable photodynamic therapy apparatus 2 according to the second embodiment of the present invention increases the power consumption per unit area within a short time by applying a structure driven by a biofuel cell and a wireless power transmission hybrid power supply module. The efficiency can be increased, and the power supply is smooth, so there is an advantage that the long-term continuous treatment can be performed.

In addition, the implantable photodynamic therapy apparatus 2 according to the second embodiment of the present invention applies a biocompatible transparent silicone cover to protect the device from moisture in the body and to expose the toxic substance of the material constituting the device to the body. There is an advantage to protect against.

In addition, the implantable photodynamic therapy apparatus 2 according to the second embodiment of the present invention has an advantage of being able to be inserted into the body by using an ultrasonic endoscope through a minimal ablation by having a diameter within 1 mm for digestive cancer.

The implantable photodynamic therapy apparatus according to the present invention described above has been described with reference to the accompanying drawings, but this is merely exemplary, and those skilled in the art may have various modifications and equivalent embodiments therefrom. I understand that it is possible.

Therefore, the true technical protection scope of the present invention should be defined only by the technical spirit of the appended claims.

1, 2: body implantable photodynamic therapy device
100: biofuel cell part
110: battery unit
120: tube member
200: light irradiation unit
210: mounting plate
220: battery unit
230: light emitting module
240: control unit
250: wireless power receiver
300: cover part

Claims (6)

A tubular biofuel cell unit having one side inserted into and fixed to a diseased part of the body and generating electric power using fuel in the body;
A light irradiation unit coupled to the biofuel cell unit and irradiating light to a lesion site in the body using power generated from the biofuel cell unit to activate a photosensitive agent injected into the body;
An implantable optical dynamics treatment device including a cover part formed of a transparent material to surround the light irradiation part to protect the light irradiation part from moisture and body fluid in the body, and to transmit light emitted from the light irradiation part. .
The method of claim 1,
The light irradiation unit
A mounting plate coupled to the other end of the biofuel cell unit;
A thin film type battery unit installed on the mounting plate and storing power generated from the biofuel cell unit;
A light emitting module disposed on the battery unit and emitting light;
A control unit including a substrate installed on one surface of the battery unit, a controller mounted on the substrate to control charge and discharge of the battery unit and operation of the light emitting module;
And a wireless power receiver configured to receive a wireless power signal transmitted from a wireless power transmitter and convert the power into a power provided on the substrate around the controller.
The method of claim 1,
And the biofuel cell unit and the cover unit are inserted into the laparoscopic for peritoneal cancer.
The method of claim 1,
The light irradiation unit
A mounting plate coupled to the other end of the biofuel cell unit;
A light emitting module including one side installed at a center of the mounting plate and the other side extending away from the mounting plate, and a plurality of LEDs mounted on the substrate;
A control unit provided on the substrate and including a controller to control an operation of the light emitting module;
The work is installed on the edge of the mounting plate and the other side is provided with a support extending away from the mounting plate, the wireless power receiver for receiving the wireless power signal transmitted from the wireless power transmission unit provided on the outer peripheral surface of the support converting into power Intra-body implantable photodynamic therapy device comprising: a.
The method of claim 4, wherein
The biofuel cell unit and the cover unit is inserted into the body type photodynamic therapy device, characterized in that formed in a diameter within 1mm to be inserted into the ultrasound endoscope for digestive cancer.
The method according to any one of claims 1 to 4,
The biofuel cell portion inserted into the lesion site in the body is further provided with an anchoring portion that is connected to the biofuel cell portion and the other side is fixed to the lesion site to prevent being drawn out from the lesion site Implantable photodynamic therapy device.

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