KR20190127385A - Patient-Specific 3D Printing Hybrid Plates - Google Patents

Abstract

The present invention relates to a patient customized 3D printing hybrid plate. More specifically, the present invention comprises an absorptive mesh-shaped cover plate covering a bone defect portion while inducing synostosis through bone conduction, and a fixing plate fixing the cover plate while providing physical bearing power for fixing and conglutinating bone fragments. The cover plate and the fixing plate are configured such that shapes of portions in contact with bones have complementary shapes to anatomical shapes of the bones as a patient-customized form based on preoperative 3D virtual surgery and 3D printing. Thus, a separate processing process of an operative in an operation room, such as curving or shaping of the plates, can be omitted. Accordingly, an objective, predictable, consistent, and predetermined level or more of an accurate operation result can be expected regardless of operative. Therefore, operation time can be shortened, pain of patients can be reduced, success rate of operation can be increased, recovery period of the patients can be reduced, complications of the operation can be minimized to prevent the complications, and bone fragments and broken bone fragments with bone defects can be stably fixed, supported, and conglutinated at the same time. Ultimately, operating expenses can be reduced.

Description

Patient-Specific 3D Printing Hybrid Plates

The present invention relates to a patient-specific 3D printing hybrid plate, and more particularly, to cover the bone defect and at the same time absorbing the cover plate in the form of an absorbent mesh that can induce bone union through bone conduction, fracture while fixing the cover plate And a securing plate that provides physical support for securing and coalescing the pieces. The cover plate and the fixed plate is configured such that the shape of the portion contacting the bone to the patient customized through the 3D virtual surgery and 3D printing before surgery to have a shape complementary to the anatomical shape of the bone, the surgeon in the operating room As it is possible to omit a separate processing process such as bending or trimming the shape, it is possible to expect more accurate and consistently more accurate surgical results regardless of who the surgeon is. Accordingly, the operation time is reduced, the pain of the patient is reduced, the success rate of the operation is improved, the recovery time of the patient is shortened, and the complications can be prevented by minimizing the complications of the surgery. The present invention relates to a patient-specific 3D printing hybrid plate that can simultaneously secure stable fixation, support and bone union, thereby ultimately lowering the overall cost of surgery.

Facial bones are the bones that form the basis of the face of the skull (skull bone), the tibia (the zygomatic bone, a), the maxilla (the maxilla.b), and the mandible (the lower jaw bone). , Mandible, c), fistula (tearbone, Lacrimal bone, d), fibula (nasal bone, Nasal bone, e), thigh bone (moisture bone, Vomer, f), inferior patella (inferior nasal shelf, Inferior nasal concha, g ). 1 is a view showing the position of each bone constituting the facial bone.

Such facial bones may cause fractures in which continuity of bone tissue is destroyed by trauma or the like. Types of fractures include compound fractures, which may damage and infect surrounding tissues and simple fractures, which may not damage and infect surrounding tissues, depending on the condition of the wound. Depending on the shape, there are complete fractures, incomplete fractures, and comminuted fractures. Depending on the direction of the fracture line, linear fracture, longitudinal fracture, and oblique line Oblique fractures, spiral fractures, and the like. Most of the fractures in the facial bones include compound fractures in which not only bone tissue but also blood vessels, nerves, and muscles around the bones are damaged at the same time, and comminuted fractures in which bones are broken into multiple fractures. many.

2 is a view showing the mandibular bone of the patient in which the fracture fracture occurs. Referring to FIG. 2, when fracture fracture occurs in the facial bone of the patient by any external force, a plurality of fracture lines L are formed on the patient's face bone. . These fracture lines (L) may have an atypical shape and intersect with each other, and the fracture fragments (F) whose outer circumference is surrounded by the fracture lines (L) by the intersecting fracture lines (L) have no point to join with the surrounding bone tissue. It can be pulled away from the surrounding bone tissue. This results in a bone defect (D), which is an empty space created by the fracture fragment (F) that is separated from the bone tissue on the bone tissue of the fractured fracture patient. Hereinafter, the fracture line (L) and bone defects (D) will be described separately by this concept.

There is no cure for bone defects associated with the contact surface at the time of fixation of the osteotomy after cosmetic surgery such as double jaw surgery, cheekbone reduction surgery, and bone defects that may be caused by facial bone fractures. As a method of treating D), a method of covering the porous titanium mesh on the bone defect part (D) or performing an overlay bone graft may be used. But if you're inducing bone growth and healing with a porous titanium mesh,

The facial soft tissue in contact with the fibrous tissue of the bone fusion may cause adhesion, which may result in unnatural facial expression or facial deformation when the facial expression is made. There is a problem that sacrifice of a donor is inevitable, such as surgery and disease occurrence in the donor. Therefore, in recent years, the use of the fixing plate 91 to hold the bones on both sides of the fracture line (L) so as not to be separated or the cover plate 95 to promote autogenous bone growth while covering the bone defects (D) It is increasing.

3 is a view illustrating a conventional fixing plate 91, which is disclosed in Korean Patent Laid-Open Publication No. 10-2016-0019245 (2016.02.19), and FIG. 4 illustrates a fracture line of a patient having a fracture. Figure is a view showing a state where the fixing plate 91 is performed. Referring to Figures 3 and 4, when a fracture occurs on the facial bones of the patient for a variety of causes, conventionally attempted to open around the fracture line (L) through the fixing plate 91 and the fixing means 93 By holding and fixing the fracture fragments (F) on both sides, the joints of the fractured bones were induced. A plurality of fixing holes 911 penetrating the other surface from one surface of the fixing plate 91 may be formed on the fixing plate 91, and the fixing means 93 may be inserted into the fixing hole 911 to provide a It was seated on the bone.

However, this conventional fixing plate 91 has a problem that it is produced and supplied uniformly according to a certain standard. Since the fixing plate 91 is not manufactured to be patient-specific, in order to couple the fixing plate 91 to the affected part of the fractured patient, first of all, the specific surgery which is determined to be the most appropriate among the standardized fixing plates 91 is performed. After the fixing plate 91 is selected, it is subjected to processing such as bending or shaping to fit the affected part of the patient. Eventually, the fixing plate 91 prepared through the rough machining process could not properly reflect the anatomical shape of the patient. When the fixing plate 91 is coupled to the affected part of the patient, as shown in FIG. 5. , The spacing space (S) was generated between the bone (B) and the fixing plate 91 coupled on the bone (B) by the fixing means (93).

Whether the fixing plate 91 could have a shape complementary to the anatomical shape of the patient's bone was entirely dependent on whether the surgeon could process the fixing plate 91 precisely to the patient's bone shape. Therefore, the conventional fixing plate 91 may cause a problem that the operation results vary depending on the skill, experience, and the like of the surgeon, and the operation inevitably generates some errors unlike those previously planned.

In addition, in the operating room, the surgeon roughly bends the fixing plate 91 to fit the shape of the patient's bone, depending on his or her experience and sensations, and brings it back to the patient's bone to reshape it if it still does not fit. Repeatedly, this resulted in a problem that the operation results were different according to the surgeon, which caused the increase of the operation time, and the pain of the patient became greater due to the increase in the operation time. It was higher than ever, resulting in an increase in the costs required to proceed with the surgery and increased the incidence of postoperative complications and reoperation.

6 shows a conventional cover plate 95, which is disclosed in US Patent Publication No. US2005 / 0149032A1. Referring to FIG. 6, when a bone defect part D occurs due to a fracture, a cover plate 95 forming a predetermined surface is provided to cover the bone defect part D. The cover plate 95 is preferably formed of an absorbent material and configured to be decomposed after surgery, and was characterized in that a plurality of through holes 951 are provided to promote bone growth.

However, as shown in FIG. 6, the conventional cover plate 95 is not manufactured to be customized to the patient, but is factory-produced to a certain standard and then implanted onto the affected part of the patient through a cutting process according to the needs of the surgery. The problem caused by the conventional fixing plate 91 is generated as it is.

In particular, the cover plate 95 is to form a surface of a constant size, having a cover plate 95 of the two-dimensional shape, to realize the facial bone of the patient of the three-dimensional shape having a variety of curvature for each part It was more difficult. What the surgeon can do to realize the two-dimensional cover plate 95 in a three-dimensional shape is the degree of bending the plate 95 by making a cutting area 953 or applying an external force as shown in FIG. 6. Because it was.

As a result, in the case of the conventional cover plate 95, the operation result was inevitably dependent on personal and subjective requirements such as the skill and experience of the surgeon, the deviation of the operation result was severe, and in the process of processing the cover plate 95, Increasing the amount of time spent on the operation caused more pain in the patient, increased the risk of surgery, increased cost of surgery, increased incidence of postoperative complications, and reoperation.

In addition, since the existing cover plate has a property to be absorbed after a certain period of time, it has been difficult to be used alone in the area that requires high strength physical support and fixing force between the fracture and the osteotomy. The conventional fixing plate 91 and the cover plate 95 were handled separately and used for the procedure. The surgeon had to store each plate with all the plates and brought them to the operating room and transplanted them after processing individually. This makes the administration and use process very cumbersome.

Accordingly, the patient-specific plate including both the physical fixation force and the support force of the fixing plate 91 and the bone conduction for filling the bone defect of the cover plate 95, and having a shape complementary to the anatomical shape of the patient by 3D printing. By fabricating, it is possible to omit the separate processing process by the surgeon in the operating room, regardless of who the surgeon can be more objectively predictable and consistently expect a certain level of accurate surgical results, and operating time To reduce the pain of the patient, increase the success rate of the operation, shorten the recovery period of the patient, minimize the complications of the operation and prevent the complications, stable fixation of the fracture fragments and osteotomy planes with bone defects, New support for simultaneous support and bone unions, ultimately lowering the overall cost of surgery A situation that the introduction of cloud technologies is required.

Korea Patent Publication No. 10-2016-0019245 (2016.02.19) United States Patent Application Publication US2005 / 0149032A1 (July 2005)

The present invention has been made to solve the above problems,

An object of the present invention includes a cover plate which induces bone conduction of a bone defect and simultaneously covers a bone defect, and a fixing plate which simultaneously fixes the cover plate and the fracture fragment and provides a physical fixation and support force. The plate and the fixed plate are configured by using 3D printing based on 3D virtual surgery such that the shape of the bone contact portion has a shape complementary to the anatomical shape of the bone, thereby bending the plate by the surgeon in the operating room or By eliminating the extra processing such as trimming the shape, it is possible to expect more accurate and consistently more accurate surgical results, shorter operation time, regardless of who the surgeon is. Reduce the patient's pain, increase the success rate of the operation, To minimize the complications of surgery and to prevent complications, and to ensure stable fixation, support, and bone union of the fracture and osteotomy sections with bone defects, which ultimately lowers the overall cost of surgery. It is to provide a 3D printing hybrid plate.

Another object of the present invention, the cover plate is configured so that at least a portion of the cover plate in contact with the fixed plate, so that the cover plate and the fixed plate can be coupled, thereby ensuring stabilization and support between the fracture pieces, It is to provide a patient-specific 3D printing hybrid plate that can promote bone formation of the bone defect site.

Still another object of the present invention, the cover plate and the fixed plate is configured to be integrally manufactured by patient customized by 3D printing, reducing the complexity of manufacturing and combining the cover plate and the fixed plate, respectively, integrally manufactured hybrid plate Osteoconduction can be achieved by drastically shortening the operation time, preventing bone defects from being left unattended, and ensuring continuity and stability of fractured fractures, by ensuring that the patient accurately matches the previously planned lesion of the patient. To provide a patient-specific 3D printing hybrid plate.

Still another object of the present invention is that the cover plate and the fixed plate is configured to be coupled to each of the patient tailored by 3D printing, so that when the cover plate and the fixed plate are integrally manufactured, both can be made of different materials. One problem is to provide a patient-specific 3D printing hybrid plate that allows the cover plate and the stationary plate to be made of different materials by using a method of separately manufacturing and combining each by 3D printing.

Still another object of the present invention is that the cover plate is composed of an absorbent plate, and the fixed plate is composed of a nonabsorbent plate, thereby filling a bone defect by a cover plate composed of an absorbent plate and promoting autogenous bone growth of a patient. It can be absorbed into the body naturally after surgery, eliminating the separate surgical procedure for removing the cover plate, and by the fixing plate composed of non-absorbent plate, the fracture fragments separated from the fracture line can be firmly fixed without being separated from each other. To provide patient-specific 3D printing hybrid plates.

Still another object of the present invention, the cover plate comprises a coupling portion, and the fixing plate is configured to include a fastening portion, when the cover plate and the fixed plate, respectively manufactured by the 3D printing to be customized to combine, It is to provide a patient-specific 3D printing hybrid plate that allows the cover plate and the fixing plate to be strongly, precisely and tightly coupled through the coupling portion and the coupling portion.

Still another object of the present invention is that the cover plate is formed in a shape complementary to the shape of the missing bone, and is configured to be seated on the bone defect, so that the cover plate of the same shape as the shape of the missing bone is bone It is to provide a patient-specific 3D printing hybrid plate that is inserted on the defect to promote bone growth, so that even after surgery, the patient's face shape can resemble the patient's original face shape before the facial bone is fractured.

Still another object of the present invention is that the cover plate, the bone defect and the face support ligament contact surface is composed of a porous material including a plurality of pores, so that the autogenous bone growth of the patient between the pores can be promoted and At the same time, by providing support and fixation forces, a patient-specific 3D printing hybrid plate can be provided that prevents the sacrifice of the donor from which bone is collected as bone grafts are not needed.

Still another object of the present invention, the fixing plate is configured to include a body portion constituting the body, and a fixing hole formed to penetrate the other surface on one surface of the body portion to receive the fixing means, the facial portion nerve and patient customized In order to prevent unexpected damage to the blood vessels, and to contact the face with other bone defects and facial ligaments, the fixation plate combined with the cover plate through non-porous surface treatment is used to prevent adhesions due to unnecessary fibrosis. By fixing to bone, a patient-specific 3D printing hybrid plate is provided that promotes bone conduction while preventing nerve and vascular damage that may occur during surgery, preventing facial deformation that may occur due to unnecessary fibrosis and adhesion after surgery.

The present invention is implemented by the embodiment having the following configuration to achieve the above object.

According to an embodiment of the present invention, the present invention includes a cover plate for covering a bone defect and a fixing plate for fixing the cover plate, wherein the cover plate and the fixing plate, the shape of the portion in contact with the bone It is characterized by having a shape complementary to the anatomical shape of the bone.

According to another embodiment of the present invention, the cover plate is characterized in that at least a portion of the cover plate is in contact with the fixed plate.

According to another embodiment of the present invention, the present invention, the cover plate and the fixed plate, it is characterized in that the 3D printing is made of a patient customized.

According to another embodiment of the present invention, the cover plate and the fixed plate is characterized in that each of the patient tailored by 3D printing and combined.

According to another embodiment of the present invention, the present invention is characterized in that the cover plate is an absorbent plate.

According to another embodiment of the present invention, the present invention, polymers, ceramics and other biocompatible materials, that is, all absorbent biocompatible materials that are currently permitted to be inserted into the human body after completion of biocompatibility evaluation, that is, Calcium phosphate compound biomaterial, Poly-L-lactide (PLLA), Poly-DL-lactide (PLA), PDLLA and Polyglycolic acid (PGA), unsintered Hydroxyapatite particles (uHA) and PLLA, PLLA or It is characterized in that any one of PDLLA and TMC (Trimethylene carbonate) or PGA (Polyglycolic acid) and β-TCP (Beta-tricalcium phosphate).

According to another embodiment of the present invention, the fixed plate is characterized in that the non-absorbent plate.

According to another embodiment of the present invention, the non-absorbent plate is characterized in that the titanium plate.

According to another embodiment of the present invention, the present invention, the cover plate, is formed in a portion in contact with the fixed plate includes a coupling portion for coupling the cover plate to the fixed plate, the fixed plate, the cover plate The cover plate and the fixing plate are coupled to the coupling part by the coupling part and the coupling part, including a coupling part formed on a position corresponding to the coupling part of the coupling part and the coupling part.

According to another embodiment of the present invention, the cover plate is formed in a shape complementary to the shape of the missing bone, characterized in that seated on the bone defect.

According to a further embodiment of the present invention, the cover plate is characterized in that the cover plate is formed of a porous material including a plurality of pores in the bone defect contact surface and the face support ligament contact surface.

According to another embodiment of the present invention, the cover plate is characterized in that the face contact surface other than the bone defect and the face support ligament contact surface is formed of a nonporous material, integral with the porous material depending on the site Or it is characterized in that formed in a stand-alone.

The present invention can obtain the following effects by the configuration, combination, and use relationship described above with the present embodiment.

The present invention includes a cover plate that induces bone conduction of bone defects and simultaneously covers the bone defects, and a fixing plate that simultaneously fixes the cover plate and the fracture pieces and provides physical fixation and support force. The fixed plate is configured by utilizing 3D printing based on 3D virtual surgery so that the shape of the part contacting the bone has a shape complementary to the anatomical shape of the bone, thereby bending the plate by the surgeon in the operating room or changing the shape. By eliminating the extra processing process such as trimming, it is possible to expect more accurate and consistently more accurate surgical results, shorter operation time, and patient's expectation regardless of who the surgeon is. Reducing pain, increasing the success rate of surgery, Complications can be prevented by minimizing the complications of the surgery, and patient-specific 3D printing, which enables stable fixation, support, and union of the bone fragments and osteotomy surfaces with bone defects, ultimately lowering the overall cost of surgery Has the effect of providing a hybrid plate.

According to the present invention, the cover plate is configured such that at least a portion of the cover plate is in contact with the fixing plate, so that the cover plate and the fixing plate can be coupled to each other, thereby securing stabilization and support force between the fracture pieces, and at the same time, a bone defect site. The effect of providing a patient-specific 3D printing hybrid plate, which facilitates bone formation, is derived.

The present invention, the cover plate and the fixed plate is configured to be integrated into the patient-customized by 3D printing, to reduce the complexity of manufacturing and combining the cover plate and the fixed plate, respectively, the integrally manufactured hybrid plate is planned in advance By precisely matching the affected area on the patient, it dramatically shortens the operation time, prevents bone defects from being left unattended, and promotes osteoconduction while ensuring continuity and stability of fractured fractures. It is effective in providing patient-specific 3D printing hybrid plates.

The present invention, the cover plate and the fixed plate is configured to be coupled to each of the patient-customized by 3D printing, so that when the cover plate and the fixed plate are integrally manufactured, the problem that cannot be composed of different materials, By using a method of separately manufacturing and combining each by 3D printing, there is an effect of providing a patient-specific 3D printing hybrid plate, which allows the cover plate and the fixed plate to be made of different materials.

The present invention, the cover plate is composed of an absorbent plate, the fixed plate is composed of a non-absorbent plate, by filling the bone defects by the cover plate composed of the absorbent plate to promote the autogenous bone growth of the patient and natural after surgery By eliminating the separate surgical procedure for removing the cover plate by absorbing into the body by the plate, the fracture plate separated around the fracture line by a fixed plate consisting of a non-absorbent plate to be held firmly and securely fixed without being separated from each other, The effect of providing a custom 3D printed hybrid plate is derived.

The present invention, the cover plate comprises a coupling portion, and the fixing plate is configured to include a fastening portion, when the cover plate and the fixed plate to be manufactured and coupled to the patient-specific customized by 3D printing, the coupling portion and It is effective to provide a patient-specific 3D printed hybrid plate that allows the cover plate and the stationary plate to be tightly, precisely and tightly coupled through the fastening.

According to the present invention, the cover plate is formed in a shape complementary to the shape of the missing bone, and is configured to be seated on the bone defect, so that the cover plate having the same shape as the shape of the missing bone is placed on the bone defect. It has the effect of providing a patient-specific 3D printing hybrid plate that is inserted to promote bone growth, so that even after surgery, the patient's face shape resembles the patient's original face shape before the facial bone is fractured.

The present invention, the cover plate, the bone defects and the face support ligament contact surface is composed of a porous material including a plurality of pores, to facilitate the growth of the patient's autogenous bone growth between the pores and at the same time By ensuring that the bone graft is no longer needed, the effect of providing a patient-specific 3D printing hybrid plate, which can prevent the sacrifice of the donor from which the bone is harvested, is derived.

The present invention, the fixing plate is configured to include a body portion constituting the body, and a fixing hole formed to penetrate the other surface on one surface of the body portion to accommodate the fixing means, the anticipation of facial nerves and blood vessels in the patient customized It prevents unsuccessful damage, and the contact surface with the bone parts other than the bone defect and the face support ligament is fixed so that the fixing plate combined with the cover plate is fixed to the patient's bone through nonporous surface treatment to prevent adhesion due to unnecessary fibrosis. Thereby, there is an effect of providing a patient-specific 3D printing hybrid plate that promotes bone conduction while preventing nerve and vascular damage that may occur during surgery and facial deformation that may occur due to unnecessary fibrosis and adhesion after surgery.

1 is a view showing the position of each bone constituting the facial bone.
Figure 2 is a view showing the mandible bone fractured patients.
3 is a view showing a conventional fixed plate.
Figure 4 is a view showing a state that the fixing plate is performed on the fracture line of the patient in which the fracture occurred.
5 is a view showing that the separation space between the fixed plate and the bone of the patient.
6 is a view showing a conventional cover plate.
7 is a perspective view of a patient-specific 3D printing hybrid plate according to an embodiment of the present invention.
8 is an exploded perspective view of FIG. 7;
9 is a view showing a cover plate according to an embodiment of the present invention.
10 is a view showing an embodiment in which the cover plate covers the bone defects.
11 is a view showing another embodiment in which the cover plate covers the bone defect.
12 is a view showing another embodiment in which the cover plate covers the bone defect.
FIG. 13 shows a facial ligament supporting ligament. FIG.
14 is a view showing an embodiment in which the shape of the contact portion of the cover plate has a shape complementary to the anatomical shape of the bone;
15 is a view showing another embodiment in which the shape of the contact portion of the cover plate has a shape complementary to the anatomical shape of the bone;
16 is a view showing another embodiment in which the shape of the contact portion of the cover plate has a shape complementary to the anatomical shape of the bone;
17 is a view showing a cover plate formed with a coupling portion according to another embodiment of the present invention.
18 is a view showing a cover plate formed with a neuroacceptor according to another embodiment of the present invention.
FIG. 19 is a view of the rear surface of FIG. 18; FIG.
20 is a view showing a cover plate formed with a neuroacceptor according to another embodiment of the present invention.
FIG. 21 is a view of the rear surface of FIG. 20; FIG.
22 is a view showing a fixing plate according to an embodiment of the present invention.
FIG. 23 is a view showing an embodiment in which the shape of a part of the fixing plate in contact with the bone has a shape complementary to the anatomical shape of the bone;
24 is a view showing a fixing plate formed with a fastening portion according to another embodiment of the present invention.
25 is a sectional view taken along the line A-A 'in FIG.
26 is a view showing that the coupling portion of the fastening portion and the cover plate of the fixed plate is coupled.
27 is a use state diagram of the present invention.

Hereinafter, with reference to the accompanying drawings, preferred embodiments of a patient-specific 3D printing hybrid plate according to the present invention will be described in detail. In the following description of the present invention, if it is determined that a detailed description of a known function or configuration may unnecessarily obscure the subject matter of the present invention, the detailed description thereof will be omitted. Unless otherwise defined, all terms in this specification are equivalent to the general meaning of the terms understood by those of ordinary skill in the art to which the present invention pertains, and in case of conflict with the meaning of the terms used herein Follow the definitions used in the specification.

In the present specification, fracture lines (L), fracture fragments (F), and bone defects (D) are repeatedly described, and the fracture lines (L) are lines that separate bones when the facial bones of the patient are broken by trauma. The fracture fragments (F) collectively referred to the bone fragments separated by the fracture line (L), the bone defects (D) fracture fractures (F) due to the intersection of the fracture line (L) and the surrounding bone tissue It refers to the empty space on the bone tissue caused by the fracture fragment (F) separated from the surrounding bone tissue while losing the point to combine with.

7 is a perspective view of a patient-specific 3D printing hybrid plate according to an embodiment of the present invention, Figure 8 is an exploded perspective view of FIG. Referring to FIGS. 7 and 8, the patient-customized 3D printing hybrid plate 1 of the present invention is manufactured to have a shape complementary to the anatomical shape of the patient, so that separate processing by the surgeon in the operating room may be omitted. As a result, no matter who the surgeon is, you can expect more than a certain level of surgical outcomes, shorten the operation time, reduce patient pain, increase the success rate of the surgery, and develop complications and reoperations. It is possible to block in advance and to lower the overall cost of the surgery, and preferably, it can be manufactured by 3D printing.

The surgeon photographs the face of the fractured patient with a medical image such as CT or MRI, implements the patient's facial bone in a three-dimensional shape on a computer based on the photographed data, and uses the patient in the three-dimensional shape. After 3D virtual surgery and modeling to determine the position, size and shape of the customized 3D printing hybrid plate 1, the patient-specific 3D printing hybrid plate 1 may be output through a 3D printer. .

The patient-specific 3D printing hybrid plate 1 includes a cover plate 10 and a fixed plate 30, wherein the cover plate 10 and the fixed plate 30 are made in patient customized by 3D printing. It may be combined with each other to be tailored to each patient by 3D printing. To this end, the cover plate 10 is preferably configured such that at least part of the contact with the fixed plate (30).

9 is a view showing a cover plate according to an embodiment of the present invention, hereinafter will be described with reference to FIG.

The cover plate 10 is configured to induce bone conduction of the bone defect part (D) while covering the bone defect part (D), by covering the portion in which the bone defect occurs due to the fracture with the cover plate (10) , Promotes autogenous bone growth in bone defects (D) to restore bone defects (D). Regarding the meaning of the covering, referring to FIGS. 10 to 12, the cover plate 10 may be formed to cover only a part of the bone defect part D, as shown in FIG. 10. In addition, as shown in FIG. 11, it may be formed to have an area larger than that of the bone defect part D to cover the entire area of the bone defect part D, as shown in FIG. 12. Similarly, the spring is preferable in a broad concept that includes a case complementary to the shape of the missing bone and is also seated on the bone defect part (D). The cover plate 10 includes a contact part 11, a non-contact part 13, a coupling part 15, and a neuroacceptor part 17.

The contact portion 11 refers to a configuration in which the cover plate 10 is formed of a porous material in contact with the bone or the face support ligament. FIG. 13 is a view showing a ligament supporting ligament. Referring to FIG. 13, as shown in FIG. 13, a subcutaneous fat (SF) is distributed for each part on the face as shown, and the facial part between subcutaneous fat (SF) for each part. Supporting ligament (G) for supporting the is positioned as shown. Therefore, the cover plate 10 covering the bone defect part (D) may be in contact with the bone, but may also be in contact with the face support ligament (G). The contact portion 11 of the cover plate 10 which is in contact with the bone or face support ligament should be able to promote bone regeneration through bone conduction and at the same time ensure a supporting force and a fixing force, it is preferably formed of a porous material. The contact portion 11 includes a void 11a.

The void 11a refers to a hole formed on the contact portion 11 of the cover plate 10, and the void 11a may be provided in plural on the cover plate 10. Through the cover plate 10 should be able to promote the growth of new bone in the bone defect (D) empty bone, preferably the contact portion 11 of the cover plate 10 has a plurality of voids ( By constructing a porous material including 11a), a plurality of micropores 11a are formed on the cover plate 10, and a patient's own bone can be rapidly grown between the micropores 11a. .

The non-contact portion 13 refers to a structure formed of a nonporous material in a portion of the cover plate 10 that does not contact the bone or the face support ligament. The non-contact portion 13 on the cover plate 10 that does not contact the bone or facial support ligament G prevents blood vessels and nerve damage and has a relatively smooth surface to prevent unnatural facial deformation after surgery due to unnecessary fibrosis and adhesion. It is preferable to be formed of a nonporous material having.

10 and 11, when the cover plate 10 is formed to cover a part or all of the bone defect part D, the cover plate 10 is formed of the contact part 11. Preferably, the shape is configured to have a shape complementary to the anatomical shape of the bone. FIG. 14 is a view illustrating an embodiment in which the shape of the contact portion 11 of the cover plate 10 has a shape complementary to the anatomical shape of the bone and is formed in a porous structure. Referring to FIG. 14, FIG. When the cover plate 10 is formed to cover the bone defects D, the contact portion 11 is required to allow the cover plate 10 to be positioned on the bone defects D. In this case, if the contact portion 11 is not complementary to the anatomical shape of the outer circumferential surface of the patient's bone B, the contact portion 11 may not form a close space on the patient's bone B and may form unnecessary spaces. In addition, this space may act as a cause of reducing the bone growth efficiency by separating the cover plate 10 from the outer peripheral surface of the bone (B), the cover plate 10 is the shape of the contact portion 11 of the bone anatomy It is preferable to be configured to have a shape complementary to the enemy shape.

More preferably, as shown in FIG. 14, the non-contact portion 13 of the cover plate 10 is also configured to have a complementary shape along the outer circumference of the missing bone, thereby receiving the cover plate 10. Allow the patient to recover close to the original facial shape after surgery.

15 is a view showing another embodiment in which the shape of the junction of the cover plate has a shape complementary to the anatomical shape of the bone. In FIG. 15, it can be seen that the shape of the junction 11 contacting the bone or face support ligament is configured to be different from that of FIG. 14. In the embodiment of FIG. 14, the contact portion 11 is formed only in the form of a simple plate, whereas in the embodiment of FIG. 15, the contact portion 11 has a substantially plate-like shape, giving irregularities to the opposite surface of the bone or face support ligament. There is a difference. That is, the shape of the contact portion 11 of the present invention is not limited to the plate shape as shown in Figure 14, as shown in Figure 15, may be configured in any number of forms.

FIG. 16 is a view showing another embodiment in which the shape of the contact portion of the cover plate has a shape complementary to the anatomical shape of the bone, wherein the cover plate 10 is shown in FIG. 12, the shape of the missing bone. When it is configured in a shape complementary to the bone defect (D), the contact portion 11 of the cover plate 10 is formed of a porous material to promote bone regeneration and to secure the support and fixing force at the same time Preferably, in the embodiment of FIG. 16, since the contact portion 11 is an end of the bone separated along the fracture line L, as shown in FIG. 14, the contact part 11 may have a shape complementary to the end of the bone. In this case, the non-contact portion 13 of the cover plate 10 may be of a non-porous structure to minimize damage to soft tissues such as blood vessels, nerves, muscles, and to prevent postoperative deformation due to unnecessary fibrosis and adhesion. It is desirable to configure the same shape as the outer circumference of the missing bone, so that the patient who receives the cover plate 10 can recover the original facial shape.

The material constituting the cover plate 10 is not limited to any particular concept, but may preferably be composed of an absorbent plate. By manufacturing the cover plate 10 to be patient-customized by 3D printing, the surgeon can omit the process such as bending the cover plate 10 in the operation process, the cover plate 10 is made of an absorbent material By doing so, the additional surgery for removing the cover plate 10 may be omitted.

The absorbent plate means a plate composed of polymer, ceramic, and other biocompatible materials, which are all absorbent biocompatible materials that are currently inserted into the human body after completion of absorbent biocompatibility evaluation. ① Calcium phosphate compound biomaterial, ② PLLA (Poly-L-lactide), ③ PDLLA (Poly-DL-lactide), ④ PDLLA and PGA (polyglycolic acid), ⑤ uHA (unsintered Hydroxyapatite particles) and PLLA, (6) PLLA or PDLLA and trimethylene carbonate (TMC) or (7) polyglycolic acid (PGA) and beta-tricalcium phosphate (β-TCP).

The coupling portion 15 is formed in a portion in contact with the fixed plate 30 refers to a configuration for coupling the cover plate 10 to the fixed plate (30). As described above, the present invention is a hybrid plate that is coupled to the cover plate 10 and the fixed plate 30, in order to include both the cover plate 10 and the fixed plate 30 at least of the cover plate 10 A part needs to be configured to be in contact with the stationary plate 30, and this contact may be made by integrally manufacturing the cover plate 10 and the stationary plate 30 by 3D printing, and the cover plate (3D printing). 10) and the fixed plate 30 may be made by combining the two. The coupling part 15 may be viewed as a configuration that is formed on the cover plate 10 under the purpose of coupling the cover plate 10 and the fixed plate 30 separately manufactured, respectively. 17 is equivalent to one embodiment of the coupling unit 15, and the coupling unit 15 is not limited to such an embodiment, and can be variously used as long as it can perform the aforementioned purpose. Can be configured.

FIG. 18 is a view illustrating a cover plate having a neural accommodating part according to another embodiment of the present invention, FIG. 19 is a view showing the rear surface of FIG. 18, and FIG. FIG. 21 is a view illustrating a cover plate on which a receiving part is formed, and FIG. 21 is a view illustrating the rear surface of FIG. 20.

The neuroacceptor 17 refers to a portion that provides a space in which the face nerve is accommodated on the cover plate 10. Preferably, as shown in FIGS. 18 to 21, the neuroacceptor 17 may apply nerves on the cover plate 10 such that the nerves are not pressed or pressed by the cover plate 10. It points to the part which was recessed to predetermined depth so that it may not interfere. More preferably, as described above, the contact portion 11 of the cover plate 10 may be made of a porous material having a rough surface, in order to prevent the nerve from being damaged by such a rough surface, facing the nerve. The opposing surface of the neuroacceptor 17 which is in contact may be made of a nonporous material. 18 and 19 illustrate an embodiment in which an accommodating space is formed inward in an upper direction of the cover plate 10 so that the orbital nerve can escape, and in the case of FIGS. 20 and 21, the face When the cover plate 10 covers the portion where the nerve travels, the cover plate 10 is recessed upwards on the lower side of the cover plate 10 so as not to be pressed or damaged by the cover plate 10 to form a concave space. The formed embodiment is shown.

22 is a view showing a fixing plate according to an embodiment of the present invention, will be described below with reference to FIG.

The fixing plate 30 refers to a configuration for fixing the cover plate 10. In addition, the fixing plate 30 may hold a separated bone on the basis of the fracture line (L) to function to fix so as not to fall apart. In addition to the cover plate 10, the fixing plate 30 is also configured to be coupled to the bone of the patient, the shape of the contact portion with the bone is preferably configured to have a shape complementary to the anatomical shape of the bone. . According to the contents shown in FIG. 22, the fixing plate 30 has a sharply bent shape. The fixing plate 30 of the present invention secures the fixing force and the supporting force to stably fix and support the fracture fragments that need fixing. Since it should be positioned at a position that can be, it may have a shape as shown in Figure 22 in some cases, the fixing plate 30 is not necessarily limited to this shape.

FIG. 23 is a view illustrating an embodiment in which a shape of a portion of the fixed plate contacting a bone has a shape complementary to an anatomical shape of a bone. Referring to FIG. 23, a bone of a patient forms various curvatures and is irregular. It is configured in the form, by reflecting the anatomical shape as it is by making the fixed plate 30 by 3D printing, bringing the fixed plate 30 prepared by the surgeon in the operating room to the affected part of the patient without additional processing Just by, it is possible to immediately seat the fixed plate 30 on the patient's bone, and can not generate unnecessary space between the patient's bone (B) and the contact surface 30a of the fixed plate (30). Will be.

More preferably, the other surface 30b of the portion 30a in contact with the bone of the fixed plate 30 also has a shape complementary to the anatomical shape of the patient's bone, so that the fixed plate 30 of the patient is implanted. It allows the face to be restored to resemble its original form.

The material of the fixed plate 30 is not limited to any particular concept, but preferably the fixed plate 30 has a function of strongly holding the bones of both sides spaced apart from the fracture line L so as not to fall from each other. In this regard, it may be desirable to configure the fixed plate 30 as a non-absorbent plate so that a predetermined strength can be secured. More preferably, the non-absorbent plate may be a titanium plate.

24 is a view showing a fixing plate formed with a fastening part according to another embodiment of the present invention. Referring to FIG. 24, the fixing plate 30 includes a body part 31 and a fixing hole 33. And a fastening portion 35.

The body portion 31 refers to a configuration constituting the body in the fixed plate (30). As shown in FIG. 24, the body portion 31 may be configured in the form of disc-shaped nodes arranged at arbitrary intervals and connecting them, but this corresponds to an embodiment of the body portion 31. The body portion 31 is not necessarily limited to this concept, and may be variously configured.

The fixing hole 33 is formed so as to penetrate the other surface on one surface of the body portion 31, the fixing plate 30 so that the fixing plate 30 can be firmly fixed on the bone of the patient of the patient Refers to a part into which the fixing means (P) for fastening with the bone is inserted. Therefore, the fixing hole 33 may be formed in plural on the body portion 31, the fixing hole 33 is preferably configured to accommodate the fixing means (P).

The fastening portion 35 is formed on a position corresponding to the coupling portion 15 of the cover plate 10 refers to the configuration coupled to the coupling portion 15. FIG. 25 is a cross-sectional view taken along line A-A 'of FIG. 24. Referring to FIG. 25, the cover plate 10 and the fixed plate 30 are separately manufactured to be customized by 3D printing as described above. The coupling portion 15 may be coupled to the rear portion, and the coupling portion 15 may be configured on the cover plate 10, and the coupling portion 35 may be coupled to the coupling portion 15. 24 shows an embodiment of the fastening part 35, and the fastening part 35 is not necessarily configured as shown, and the coupling part 15 of the cover plate 10 is shown. Anything that can be fastened with can be configured in various ways. Referring to FIG. 26, if the coupling part 15 of the cover plate 10 is configured in the form of a protruding protrusion, the fastening part 35 of the fixing plate 30 may receive the protrusion. It can be configured in such a way that it can. In order to do this, of course, the position of the coupling part 15 of the cover plate 10 and the position of the fastening part 35 of the fixed plate 30 should correspond to each other. In addition, the coupling portion 15 and the coupling portion 35 may be configured to increase the coupling force between the cover plate 10 and the fixed plate 30 is composed of a plurality.

27 is a state diagram used in the present invention. Referring to FIG. 27, when a fracture occurs in the facial bone of the patient due to trauma, the surgeon acquires the facial bone data of the patient using CT, MRI, and the like by implementing it in three dimensions on a computer, It has a three-dimensional shape to design a plate for facial bone surgery. When the modeling of the plate is completed according to the surgical plan, the plate output is performed using a 3D printer, through which the patient-specific 3D printing hybrid plate 1 is made. The surgeon can not only manufacture the patient-specific 3D printing hybrid plate 1 in which the cover plate 10 and the fixed plate 30 are combined with the shape of the patient's bone, but also separately manufactured. It is also possible to combine them. The patient-specific 3D printing hybrid plate (1) made through such a process eliminates the need for processing such as bending the plate depending on the skill or experience of the surgeon in the operating room, thereby providing a more objective level regardless of who the surgeon is. It is possible to expect the above surgical results, shorten the operation time, reduce the pain of patients, increase the success rate of surgery, prevent the occurrence of complications and reoperation in advance, and reduce the overall cost of surgery.

The foregoing detailed description illustrates the present invention. In addition, the above-mentioned content shows and describes preferred embodiment of this invention, and this invention can be used in various other combinations, changes, and environments. That is, changes or modifications may be made within the scope of the concept of the invention disclosed in the present specification, the scope equivalent to the disclosures described above, and / or the skill or knowledge in the art. The described embodiments illustrate the best state for implementing the technical idea of the present invention, and various modifications required in the specific application field and use of the present invention are possible. Thus, the detailed description of the invention is not intended to limit the invention to the disclosed embodiments. Also, the appended claims should be construed to include other embodiments.

1: Patient Custom 3D Printing Hybrid Plate
10: cover plate 11: contact
11a: void 13: non-contact portion
15: coupling unit 17: neuroreceptor unit
30: fixed plate 31: body portion
33: fixing hole 35: fastening portion
L: Fracture line F: Fracture fragment
D: bone defect P: fixation means

Claims (12)

A cover plate for inducing bone conduction of the bone defect while covering the bone defect;
It includes a fixing plate for fixing the cover plate and the fracture pieces,
The cover plate and the fixed plate, the patient-specific 3D printing hybrid plate, characterized in that the shape of the portion in contact with the bone by the 3D printing has a shape complementary to the anatomical shape of the bone. The patient-specific 3D printing hybrid plate of claim 1, wherein the cover plate is in contact with at least a portion of the cover plate in contact with the stationary plate. According to claim 2, The cover plate and the fixed plate, the patient-specific 3D printing hybrid plate, characterized in that the patient-made by 3D printing integrally manufactured. The patient-specific 3D printing hybrid plate according to claim 2, wherein the cover plate and the fixed plate are each manufactured and combined to be patient-specific by 3D printing. The patient-specific 3D printing hybrid plate according to claim 4, wherein the cover plate is an absorbent plate. According to claim 5, The absorbent plate is a polymer compound (Polymer), Ceramic (ceramic) and other biocompatible materials, that is, materials that are currently approved for insertion into the human body after completion of the biocompatibility evaluation (ie, calcium phosphate composite biocompatible material ( Calcium phosphate compound biomaterial (PLLA), Poly-L-lactide (PLLA), Poly-DL-lactide (PDLLA), PDLLA and polyglycolic acid (PDLLA), unsintered Hydroxyapatite particles (uHA) and PLLA, PLLA or PDLLA and TMC (Trimethylene carbonate) Or PGA (Polyglycolic acid) and β-TCP (beta-tricalcium phosphate), characterized in that the patient-specific 3D printing hybrid plate. The patient-specific 3D printing hybrid plate according to claim 5, wherein the fixed plate is a non-absorbent plate. 8. The patient-customized 3D printing hybrid plate of claim 7, wherein the nonabsorbable plate is a titanium plate. The cover plate of claim 4, wherein the cover plate includes a coupling part formed at a portion in contact with the fixing plate to couple the cover plate to the fixing plate, wherein the fixing plate has a position corresponding to the coupling part of the cover plate. And a coupling part formed at the coupling part and coupled to the coupling part, wherein the cover plate and the fixed plate are coupled to each other by the coupling part and the coupling part. The method of claim 1, wherein the cover plate, the contact portion formed of a porous material and the non-contact portion formed of a nonporous material,
The contact portion is formed in a portion of the cover plate in contact with the bone or face support ligament, the non-contact portion is formed in a portion of the cover plate not in contact with the bone or face support ligament, patient-specific 3D printing hybrid plate . 11. The patient-specific 3D printing hybrid plate according to claim 10, wherein the cover plate further comprises a neuroacceptor that provides a space in which the nerve is accommodated. The patient-specific 3D printing hybrid plate according to claim 1, wherein the fixing plate comprises a body portion constituting a body and a fixing hole formed through one surface of the body portion to receive the fixing means. .

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