KR20190122251A - 암의 치료 방법 - Google Patents
암의 치료 방법 Download PDFInfo
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- KR20190122251A KR20190122251A KR1020197029033A KR20197029033A KR20190122251A KR 20190122251 A KR20190122251 A KR 20190122251A KR 1020197029033 A KR1020197029033 A KR 1020197029033A KR 20197029033 A KR20197029033 A KR 20197029033A KR 20190122251 A KR20190122251 A KR 20190122251A
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- compound
- cancer
- hepatocellular carcinoma
- fxr
- pharmaceutically acceptable
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- DVPVGSLIUJPOCJ-XXRQFBABSA-N x1j761618a Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(=O)CN(C)C)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(=O)CN(C)C)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 DVPVGSLIUJPOCJ-XXRQFBABSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201762468259P | 2017-03-07 | 2017-03-07 | |
| US62/468,259 | 2017-03-07 | ||
| PCT/US2017/052663 WO2018164715A1 (en) | 2017-03-07 | 2017-09-21 | Methods of treating cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20190122251A true KR20190122251A (ko) | 2019-10-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| KR1020197029033A Withdrawn KR20190122251A (ko) | 2017-03-07 | 2017-09-21 | 암의 치료 방법 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP3592357A4 (https=) |
| JP (1) | JP7042836B2 (https=) |
| KR (1) | KR20190122251A (https=) |
| CN (1) | CN110430882A (https=) |
| AU (1) | AU2017402623A1 (https=) |
| CA (1) | CA3055308A1 (https=) |
| IL (1) | IL269123A (https=) |
| TW (1) | TW201832768A (https=) |
| WO (1) | WO2018164715A1 (https=) |
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| WO2022011037A2 (en) * | 2020-07-07 | 2022-01-13 | The General Hospital Corporation | Interleukin 33 (il-33) inhibition for treatment of cancer, fibrosis and inflammation |
| EP4402264A4 (en) * | 2021-09-16 | 2025-10-15 | Agency Science Tech & Res | MODULATION OF TJP1 EXPRESSION TO TREAT LIVER DISEASES |
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| WO2003080803A2 (en) * | 2002-03-21 | 2003-10-02 | Smithkline Beecham Corporation | Methods of using farnesoid x receptor (fxr) agonists |
| PT2040713E (pt) | 2006-06-27 | 2014-10-13 | Intercept Pharmaceuticals Inc | Para a prevenção ou o tratamento de doenças ou estados clínicos mediados por fxr |
| WO2013037482A1 (en) * | 2011-09-15 | 2013-03-21 | Phenex Pharmaceuticals Ag | Farnesoid x receptor agonists for cancer treatment and prevention |
| SG11201503697TA (en) * | 2012-11-28 | 2015-06-29 | Intercept Pharmaceuticals Inc | Treatment of pulmonary disease |
| WO2015183794A1 (en) * | 2014-05-27 | 2015-12-03 | City Of Hope | Tgr5 agonist complexes for treating diabetes and cancer |
| US11578097B2 (en) * | 2014-11-26 | 2023-02-14 | Enanta Pharmaceuticals, Inc. | Tetrazole derivatives of bile acids as FXR/TGR5 agonists and methods of use thereof |
| PE20180690A1 (es) | 2015-04-27 | 2018-04-23 | Intercept Pharmaceuticals Inc | Composiciones de acido obeticolico y metodos de uso |
| WO2017180577A1 (en) | 2016-04-13 | 2017-10-19 | Intercept Pharmaceuticals, Inc. | Methods of treating cancer |
-
2017
- 2017-08-11 TW TW106127326A patent/TW201832768A/zh unknown
- 2017-09-21 EP EP17899634.4A patent/EP3592357A4/en not_active Withdrawn
- 2017-09-21 CN CN201780088500.7A patent/CN110430882A/zh active Pending
- 2017-09-21 AU AU2017402623A patent/AU2017402623A1/en not_active Abandoned
- 2017-09-21 CA CA3055308A patent/CA3055308A1/en not_active Abandoned
- 2017-09-21 KR KR1020197029033A patent/KR20190122251A/ko not_active Withdrawn
- 2017-09-21 WO PCT/US2017/052663 patent/WO2018164715A1/en not_active Ceased
- 2017-09-21 JP JP2019548368A patent/JP7042836B2/ja active Active
-
2019
- 2019-09-04 IL IL26912319A patent/IL269123A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3055308A1 (en) | 2018-09-13 |
| JP2020510009A (ja) | 2020-04-02 |
| AU2017402623A1 (en) | 2019-09-26 |
| EP3592357A1 (en) | 2020-01-15 |
| WO2018164715A1 (en) | 2018-09-13 |
| CN110430882A (zh) | 2019-11-08 |
| EP3592357A4 (en) | 2021-01-13 |
| IL269123A (en) | 2019-11-28 |
| JP7042836B2 (ja) | 2022-03-28 |
| TW201832768A (zh) | 2018-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20191002 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination |