KR20190080794A - A device and method to induce the improvement of blood circulation in brain - Google Patents

Abstract

The present invention relates to an apparatus and a method for inducing enhancement of a brain blood circulation, which can be used for treating or preventing a brain-related disease and improving memory and concentration. The apparatus of the present invention comprises: a light irradiator having a light source and irradiating light; and a light irradiation control apparatus generating a light irradiation control signal and transmitting the same to the light irradiator.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a device and a method for inducing cerebral blood circulation enhancement,

The present invention relates to an apparatus and method for inducing cerebral blood circulation enhancement, and more particularly, to a method and apparatus for inducing cerebral circulation enhancement by using light energy, that is, Photo-innervated Neuro-stimulation (PINS) Apparatus and method for inducing brain blood circulation enhancement by relaxing blood vessels (blood vessel muscles) in the brain by stimulating nerve endings distributed in the epidermis layer or dermis layer below the surface .

Blood can be said to be responsible for the metabolism of the whole body, and it takes charge of all the work necessary to support life by going around every corner of the human body. The blood carries the oxygen from the lungs to each tissue or cell, plays a role in bringing the nutrients from the stomach or intestine to the right place, and sends oxygen and nutrient residue from tissues and cells to the excretory organ It also plays a role. Therefore, healthy blood must flow well for all of these functions. The blood vessels consist of blood vessel muscle cells.

The brain receives blood and oxygen through the carotid artery 71 and the vertebral artery 72 as shown in Fig.

The carotid artery is a branch of the aorta, and the left and right carotid arteries from the aortic arch are raised to the outside of the larynx and into the face and head of the head. The carotid artery is divided into the internal carotid artery near the thyroid gland, the external carotid artery in the head of the head, and the internal carotid artery in the cerebral artery.

The vertebral artery (the vertebral artery) is one of the arteries distributed in the brain. The vertebral artery divides from the base of the subclavian artery (the subclavian artery) on both sides, ascends and enters the transverse pore of the sixth cervical vertebra, (Upper part of the first cervical vertebra) to the lower part of the lower part of the vertebral body, penetrates the dura mater and the subarachnoid space, enters the lower part of the subarachnoid space, It enters the cranium from the ball.

In particular, the brain needs to be supplied with about 20% of the blood from the heart, so that if the oxygen in the blood is insufficient, the brain itself will supply more blood to the brain to fill the deficient oxygen. As a result of the activity, the brain pressure is increased. Suddenly, when the pressure of the brain suddenly increases, the circulation of the blood is not smooth and the oxygen supply is not good, so headache or dizziness is reported to occur.

As the carotid arteries or vertebral arteries supplying the energy and oxygen needed for the brain become narrower, blood circulation becomes less smooth and blood circulation in the brain is often lowered. Decreased memory due to lower blood circulation in the brain and headache when the work efficiency or learning ability is lowered, which causes the stress again, and vicious cycle is repeated. Thus, the problem of cerebral blood circulation is very important because it can cause diseases such as cognitive dysfunction, vascular dementia, Alzheimer's dementia and Parkinson's disease as well as causing headache or dizziness.

Symptoms such as cognitive dysfunction, vascular dementia, Alzheimer's dementia, and Parkinson's disease cause problems in the smooth muscle contraction and relaxation of the blood vessels in the brain. As a result, blood circulation in the brain is not smooth for a long time, It is known to be caused by a lack of oxygen and nutrient supply. In addition, since the blood circulation is not smooth, the neuroglial cells responsible for the cleansing system in the brain are damaged or weakened, and the metabolites such as metabolites of various cells coming out from the daily can not be properly discharged every day, It is known that diseases such as Alzheimer ' s dementia are caused by accumulation of plaque.

Numerous new drug development studies have been conducted to treat or alleviate symptoms such as cognitive dysfunction and dementia, but treatment or symptom improvement has not been as successful as drugs. In addition, there are attempts to mitigate symptoms by using alternatives such as acupuncture, moxibustion, and hyperthermia, or by stimulating brain cells using electric or magnetic fields and far infrared rays, but the effect is almost negligible. And drug treatment is a serious problem of side effects of drugs. Alternative therapies such as acupuncture or moxibustion can cause injuries or burns to the human body, and disinfection can lead to unsanitary problems. In addition, the electric or magnetic field therapy apparatus is inconvenient to use because it is difficult to accurately determine the location of the stimulus or the scale is large, and the effect of improving the symptom is inferior or the effect is relatively good in the case of a nerve stimulator inserted into a part of human body. The cost of surgery and the cost of equipment are high.

On the other hand, it is a light irradiation device that stimulates the brain using low level light therapy (LLLT) technology. However, since rays must penetrate the skull of the brain, the light intensity in the far infrared wavelength region It is necessary to provide a cooling device for preventing the temperature from rising due to the increase of the temperature of the brain due to the light beam or the light output of the light beam irradiator becomes large, It is inconvenient to use because of increased power consumption and increased weight and size of equipment.

Recently, it has been reported that cerebral blood circulation is closely related to improvement of learning, memory and concentration, cognitive dysfunction, Alzheimer's dementia and Parkinson's symptoms. Therefore, it is easier and more convenient to improve cerebral blood circulation The development of new devices and methods for deriving the information is urgently required.

The inventors of the present invention have disclosed patents relating to a ray therapy apparatus as disclosed in Korean Patent Publication No. 10-2012-0131316, Korean Patent No. 10-1225135, Korean Patent Publication No. 0-2016-0049097, Korean Patent Publication No. 10-2016-0054423 Korean Patent No. 10-1225135, and the like.

As a prior art, Korean Patent No. 10-1009462 discloses a near-infrared ray therapy apparatus for irradiating near-infrared rays to the inside of the skull and two base regions for the treatment of dementia and the like. Because it is different, it has to be made customized and is inconvenient to carry.

(Patent Document 1) Korean Patent No. 10-1009462

Disclosure of Invention Technical Problem [8] The present invention has been made to solve the above-mentioned problems, and an object of the present invention is to provide a nerve endings (nerve endings) distributed in the epidermis layer or the dermis layer beneath the surface of the skin, Endings are stimulated for a certain period of time and induced to secrete substances such as nitric oxide from the nerve endings of the stimulated nerve endings and the nitrergic nerve terminals connected to the peripheral nervous system, (Cerebral blood circulation enhancement induction device) and method for inducing cerebral blood circulation enhancement by relaxation of cerebral blood vessels in contact with nitrergic nerve terminals using a substance as a substance.

In order to solve the above problems, an apparatus for inducing cerebral blood circulation enhancement of the present invention comprises a light source, a carotid artery supplying blood and oxygen to the brain, Or a vertebral artery corresponding portion, in accordance with a beam irradiation control signal; And a beam irradiation control device for generating a beam irradiation control signal according to the setting data including the irradiation time and transmitting the beam irradiation control signal to the beam irradiation device.

The light beam irradiator stimulates nerve endings distributed in the skin layer or the dermal layer below the skin surface of the carotid artery corresponding part or the vertebral artery corresponding part by irradiating light for a predetermined light irradiation time, Nitrogenic nerve terminals connected to the distal end of the nervous system induce the secretion of nitric oxide-containing substances, which secrete the brain blood vessels and lymph vessels in contact with the nerve active nerve terminals Relaxation, and induce the promotion of cerebral blood circulation.

The light beam irradiator relaxes the cerebral blood vessels and the lymph vessels in contact with the nitrogen active nerve endings and induces the enhancement of the cerebral blood circulation so that the injured cells functioning as a brain clearance system such as an astrocyte , To increase the oxygen and nutrient supply to slowly restore the function of the damaged brain cleansing system and to suppress the accumulation of amyloid beta plaques by emitting visible light, And is controlled by the light beam irradiation control device so as to automatically terminate the visible light emission when the set light irradiation time is ended.

The beam irradiation control device can wirelessly transmit the beam irradiation control signal to the beam irradiator, wherein the beam irradiator incorporates a battery. Alternatively, the light beam irradiation control device may transmit the light beam irradiation control signal to the light beam irradiator, wherein the light beam irradiator is driven by a power source transmitted from the light beam irradiation control device.

The carotid artery counterpart may be a position of an ankle hemorrhage in the neck of a person or an animal and the vertebral artery counterpart may be a position of a corticosteroid or a hemostatic hemorrhage in the neck of a person or an animal.

The ray irradiator is a straight line distance from the frontal surface of the neck to the vertical line from the earlobe to the midline or laryngeal projection from the left and right sides of the median or the laryngeal projection (Adam's Apple) to the frontal center-earlobber distance From the midline to the midline of the earlobe, from the midline to the midline of the earlobe, from the midline to the midline of the earlobe.

The ray irradiator is a straight line distance from the back of the neck to the vertical line from the earlobe to the vertical line from the mid-point to the mid-point or from the left side to the laryngeal projection (Adam's Apple). It can be mounted from the midpoint to the midpoint of the back midpoint to the earlobe from the midpoint of the back midpoint to the midpoint of the earlobe.

The light source is a combination of one or more of LED, OLED or micro LED, and the light beam irradiator has a peak wavelength of 590 nm to 620 nm and a light intensity of 1 mW / cm 2 to 5 mW / cm 2 To be emitted.

The apparatus further comprises an attaching device for attaching the light beam irradiator to the animal or person so as to irradiate the light beam irradiator carotid artery counterpart or the vertebral artery counterpart with light, wherein the attacher is a double-sided tape, an absorbing tool, a head gear, Lt; / RTI >

The light beam irradiator is configured to emit a light ray for 10 to 20 minutes in order to stimulate the carotid artery counterpart or vertebral artery counterpart once. The light beam irradiation control device is a smart phone, a PDA, a notebook, an Android phone, A watch, and a computer, and the light beam irradiator further includes a light ray filter.

When the periodic treatment mode switch provided in the light beam irradiation control device is selected, the light beam irradiation control device generates a light beam irradiation control signal so that the light beam irradiator emits a light beam for a predetermined light beam irradiation time every predetermined time interval , And transmits it to the beam irradiator.

If the attaching device is one of a headgear, a neckline, and a necklace, a light irradiation control device or a light irradiation device may be incorporated in the attaching device.

The device and method for inducing cerebral blood circulation enhancement of the present invention can be applied to the epidermis layer or the dermis layer beneath the skin surface of a specific region of the neck and the back of a neck using PINS Stimulated nerve endings for a certain period of time and released nitric oxide (NO) from nitrergic nerve terminals connected to the stimulated nerve endings and peripheral nervous system Induced relaxation of the cerebral blood vessels contacting the nitrergic nerve terminals with the secreted substance to induce the cerebral circulation to be promoted, thereby treating or preventing a disease caused by the lack of cerebral blood circulation. Particularly, the present invention does not require a cooling device, is small in size and weight, consumes less power, is inexpensive, and is easy to carry.

The apparatus and method for inducing cerebral blood circulation enhancement of the present invention are useful for treating or preventing various cerebral diseases such as vascular dementia caused by a lack of cerebral blood circulation and Alzheimer's dementia, stroke, migraine, depression, Parkinson's disease, It can be used to improve learning and improve memory and concentration, which can contribute to improving the quality of life of mankind. In addition, it can greatly contribute to the development of the medical device industry used for treating or preventing the above-mentioned diseases.

1 is a schematic view for explaining a carotid artery and vertebral artery;
FIG. 2 is a view showing a use state of an apparatus for inducing cerebral blood circulation enhancement according to an embodiment of the present invention.
3 is a view showing a state of use of an apparatus for inducing cerebral blood circulation enhancement according to another embodiment of the present invention.
FIG. 4 is a view for explaining a position where a light beam irradiator of the present invention is adhered to or close to a human body to be irradiated with visible light. FIG.
5 is a view for explaining a position where a light beam irradiator of the present invention is adhered to or close to a neck portion of an animal to be irradiated with visible light.
6 is an example of the light beam irradiator 200 of the present invention.
7 is a block diagram showing the configuration of an apparatus for inducing cerebral blood circulation enhancement of the present invention.
8 is a graphical example of a result of a cerebral angiogram before and after a light stimulus applied to an animal using an apparatus and a method for inducing cerebral blood circulation enhancement according to the present invention.
FIG. 9 is a graph showing the degree of vascular relaxation according to the diameter of blood vessels before and after light stimulation in an animal using an apparatus and method for inducing cerebral blood circulation enhancement according to the present invention.
10 is a graph showing an experimental protocol in which cerebral blood circulation is induced by relaxation of cerebral blood vessels in a normal person by using an apparatus and a method for inducing cerebral blood circulation enhancement according to the present invention and results of experiments .

Hereinafter, an apparatus and method for inducing cerebral blood circulation enhancement of the present invention will be described in detail with reference to the accompanying drawings.

FIG. 2 is a view showing a state of use of an apparatus for inducing cerebral blood circulation enhancement in an embodiment of the present invention, and FIG. 3 is a diagram showing a use state diagram of an apparatus for inducing cerebral circulation enhancement in another embodiment of the present invention .

The device 100 for inducing cerebral blood circulation enhancement is a device for relaxing the blood vessels, that is, the blood vessel muscles, by irradiating light to specific areas of the neck where blood vessels (carotid or vertebral arteries) (Stimulating and activating) the supply of blood and oxygen to the brain, and includes a light beam irradiator 200, an attaching device 300, and a light beam irradiation control device 500.

The device 100 for inducing cerebral blood circulation enhancement of FIG. 1 shows an example in which a light beam irradiator 200 and a control device 500 are connected by a wire, and the light beam irradiator 200 and the light irradiation control device 500 are connected And further includes a cable 400. That is, the device 100 for inducing cerebral blood circulation enhancement in FIG. 1 is a case where a double-sided tape is used as the attaching device 300, and the light beam irradiator 200 is a device for irradiating the light irradiation control device 500 with the cable 400 Receives the light from the light irradiation control device 500, and receives the light irradiation control signal from the light irradiation control device 500. For example, the light beam irradiator 200 may be attached to the skin surface of a specific area of an animal or human body using a double-sided tape, and the user may carry out the light beam irradiation while the user is carrying the light beam irradiation control device 500 connected by the cable 400 .

2 shows an example in which the light beam irradiator 200 and the light irradiation control device 500 are wirelessly connected to each other and the light beam irradiator 200 and the light beam irradiation control device 500 are connected to the wireless transceiver .

2, if the battery 200 and the wireless transceiver are further incorporated in the light beam irradiator 200, the light irradiator 200 is operated separately from the light beam irradiation control device 500, The light irradiation can be controlled.

The light beam irradiator 200 is a means for emitting light in accordance with the light beam control signal received from the light beam irradiation control device 500, and is mounted on the human or animal body by the attacher 300. The light beam emitted from the light beam irradiator 200 is emitted such that the peak wavelength of the light beam is 590 nm to 620 nm and the intensity of the light beam is 1 mW / cm 2 to 5 mW / cm 2. The light source 270 embedded in the light beam irradiator 200 may be a combination of one or more of LED (Light Emitting Diode) or OLED or micro LED.

The attaching unit 300 is a means for attaching or bringing the light irradiator 200 to the neck or the neck, such as a double-sided tape or a suction tool, a headgear or a necklace Lt; / RTI >

The light irradiation control device 500 includes a display unit 530, an arithmetic processing unit 550 (a microprocessor or a light irradiation control circuit), a wireless transmitting / receiving unit 510, A power supply 590, a key input (such as an on / off switch (start button and end button)), a light irradiation operation indicator (e.g., LED) (not shown), an alarm device (not shown) And the light beam irradiation control device 500 may be a microprocessor, a microcontroller, a computer, or a portable personal terminal (smart communication device). In some cases, the light irradiation control device 500 may be a microprocessor or a microcontroller, and a smart communication device. The portable personal terminal (smart communication device) is a smart communication device such as a smart phone, a PDA, a notebook, an Android phone, an iPhone, or a smart watch and has a predetermined application program installed thereon. The light irradiator 200 can be controlled to receive the light beam treatment.

The light irradiation control device 500 may be manufactured to be large and strong so as to be installed in a hospital, so that it can be manufactured as a hospital for an animal or a patient to visit and receive light irradiation by using the light irradiation device 200.

The light beam irradiation control apparatus 500 may include a microprocessor or a microcontroller when the attachment device 300 is in the form of a headgear or a hairband to which the attachment device 300 is attached to the ear or head and may be built and installed in a part of the body of the headgear or the hairband. have. In this case, the light irradiation control device 500 may be connected to the smart communication device by wired or wireless connection, and the light irradiation device 200 may be controlled by the smart communication device.

The light irradiation control device 500 is built and installed in a part of a necklace when the attachment 300 is in the form of a necklace. In this case, the light irradiation control device 500 may be connected to a smart communication device by wire or wirelessly And control the light irradiation control device 500 to the smart communication device so as to control the light irradiation of the light irradiation device 200.

A light source 200 for emitting a visible light emitted from the light source and a light source for emitting a light beam of a visible light ray in a visible light wavelength band and a light ray filter are mounted on a surface of the light source 200, The nerve endings distributed in the epidermis layer or the dermis layer beneath the skin surface of the area are directly stimulated for a certain period of time, Nerve endings and nitrergic nerve terminals connected to the nervous system induce the secretion of nitric oxide, which secretes nitrergic nerve terminals. The relaxation of the blood vessels and lymphatic vessels that are in contact with the brain leads to the enhancement of circulation and circulation of the brain, resulting in a brain clearance system such as an astrocyte (Ie, the damaged astrocytes that function in the brain's cleansing system) to improve oxygen and nutrients to slowly restore the function of the damaged brain's cleansing system to form amyloid beta plaques ), So that the visible light is emitted during the predetermined light irradiation time and the visible light emission is terminated when the predetermined time is ended.

In general, astrocyte is sometimes called astrocyte, and it is also called 'clean cell'.

The light beam irradiation control apparatus 500 is configured such that the light beam irradiator 200 irradiates the right and left vertebral arteries of the right or left vertebral artery of the animal or the human body or the left and right carotid arteries 1 The nerve endings distributed in the dermis or the epidermis beneath the surface of the skin at the location of the vertebral artery or the carotid artery are exposed to the visible light ray Stimulated for a predetermined period of time to induce secretion of nitric oxide by nNOS in nitrergic nerve terminals around the cerebral blood vessels connected to the nerve endings and peripheral nerves, The cerebral blood circulation and the lymphatic circulation which are in contact with the nitrogen active nerve end are loosened to repeatedly induce cerebral blood circulation and lymphatic circulation enhancement, (Astrocyte) was gradually restore the function of the cleaning system of the damaged brain functions damaged cells that is responsible for the cleaning of the brain (clearance) system, to enhance oxygen and nutrient supply, such as to inhibit the accumulation of beta amyloid plaques.

Fig. 4 is a view for explaining a position where a light beam irradiator of the present invention is adhered to or close to a human neck to be irradiated with visible light. Fig.

4 (a) shows a front view of the subject, showing a state in which the light beam irradiator 200 is attached to the carotid artery corresponding portion of the neck of the examinee. For example, the straight line distance from the midline portion 70 or the laryngeal projection 60 to the line perpendicular to the earlobe, on the left and right sides with respect to the midline portion 70 or the Adam's Apple 60, Is referred to as " front center-earlobber distance " for convenience of explanation in the present invention. The frontal midline-earlobe distance can be approximately one quarter of the neckline. Then, in order to mount the light beam irradiator 200 on the carotid artery corresponding portion, the light beam irradiator 200 is moved from the midpoint portion 70 or the laryngeal projection 60 to the front midplane- It can be mounted up to 2/3 of the earlobe distance.

Alternatively, when the light beam irradiator 200 is mounted on the carotid artery corresponding portion of the neck of a subject, as shown in Fig. 4A, the light beam irradiator 200 is attached to the forehead of the subject's forehead (neck portion front face) Can be mounted. The numbness is the position where the horizontal line and the sternocleidomastoid meet when the horizontal line is drawn along the neckline at the laryngeal projection 60 to a point 6 cm from the laryngeal projection 60 to the side, . Here, Sternocleidomastoid is a muscle that stops at the bulbous proximal origin, originating from the sternum and clavicle.

4 (b) shows the back surface (back surface) of the subject, showing the state in which the ray irradiator 200 is attached to the vertebral artery corresponding portion of the neck of the subject. For example, in the present invention, the straight line distances from the left and right sides with respect to the center portion 70 to the vertical line from the ear tip to the ear canal are referred to as "rear center portion-earlobe distance". Rear midrange-earlobbing distance can be approximately 1/4 length of neckline. Then, in order to mount the light beam irradiator 200 on the vertebral artery corresponding portion, the light beam irradiator 200 is moved from the midpoint 70 to the midpoint of the back midpoint to the earlobe from the midpoint of the back midpoint to the earlobe, It can be installed up to 3 points.

4B, when the light beam irradiator 200 is mounted on the vertebral artery corresponding portion of the subject's neck, the light beam irradiator 200 is placed on the back of the neck of the subject (neck portion back) Can be mounted. Here, the cervical cord blood is a hemorrhagic septum located at the back of the throat, and a hemisphere of about 1 to 3 cm on both sides of the midpoint of the border of the back hair (more specifically, about 1 cm downward from the neck of the neck of the back of the neck) Is located at the outer boundary of the trapezius.

4B, when the light beam irradiator 200 is attached to the vertebral artery corresponding portion of the subject's neck, the light beam irradiator 200 is attached to the wind bleeding of the nape of the subject's neck (back of the neck portion) Can be mounted. Here, air hemostasis refers to two concave depressions 1.5 cm away from the center of the back of the throat, slightly outward of the celiac blood.

In other words, the light beam irradiator 200 is attached to each of the right and left carotid artery corresponding parts of the neck of the examinee, and the light beam irradiator 200 is moved from the medial part 70 or the laryngeal protuberance 60 to the frontal mid- It can be mounted from 2 points to 2/3 of the frontal mid-earlobe distance. The light beam irradiator 200 is attached to each of the right and left vertebral artery corresponding parts of the neck of the examinee so that the light beam irradiator 200 can be moved from the midpoint 70 to half of the rear midpoint- - It can be mounted up to 2/3 of the earlobe distance.

That is, two light beam irradiators 200 can be attached to the carotid artery corresponding portion of the subject's neck, or two light beam irradiators 200 can be attached to the vertebral artery corresponding portions of the subject's neck. It is possible to simultaneously mount two light beam irradiators 200 on the carotid artery corresponding part of the neck part and two light beam irradiators 200 on the vertebral artery corresponding parts of the neck part.

5 is a view for explaining a position where a light beam irradiator of the present invention is adhered to or close to a neck portion of an animal to be irradiated with visible light.

In the case of an animal (for example, a child, a cat, etc.), a light beam irradiator 200 is attached (adhered) to or close to the catheter blood of an animal to mount the light beam irradiator 200 on a part of the vertebral artery.

The cortex blood of an animal (e. G., A child, a cat, etc.) can be about one-half point between the ear starting point (5) above the head of the animal and the median of the animal.

In addition, although not shown, in the case of an animal (for example, a child, a cat, etc.), a light beam irradiator 200 is adhered (mounted) to a porphyrist of an animal to mount a light irradiator 200 on a carotid- Or proximity.

The papules of an animal (e. G., A pussy, a cat, etc.) can be about one-half the distance from the animal's ear end point to the median part of the animal.

The method of relaxing the blood vessels in the brain using the apparatus 100 for inducing cerebral circulation enhancement according to the present invention is a method for relaxing the blood vessels in the cerebral blood circulation by using a carotid artery in each of the left and right vertebral arteries, Two light beam irradiators 200 are attached to the surface of the skin at one site or directly to the surface of the skin using the attacher 300 and then are distributed to the dermis or epidermis beneath the surface of the skin at the position of the vertebral artery or carotid artery Nerve endings are stimulated with visible light emitted from the light irradiator 200 once for 10 minutes to 20 minutes to form nitric oxide radicals in the nitrergic nerve terminals connected to the nerve terminal and the peripheral nerve (nitric oxide) and secretion of such substances to contact with the nitrile nerve terminal (nitrergic nerve terminals) is a way to relax the cerebral blood vessels, It induces enhanced.

6 is an example of the light beam irradiator 200 of the present invention, and is an example of a cylindrical light beam irradiator using one light source 11.

A PCB 10 provided with a light source 11, a body 20 accommodating the PCB 10 and a power jack 40 connected to the body 20 through a wire 30.

The PCB 10 incorporates a light source 11 in the form of one or more of LED (Light Emitting Diode) or OLED or micro LED, and supplies driving power to the light source 11. The driving power may be received from the battery built in the light beam irradiator 200, and may be received from the light irradiation control device 500, as the case may be.

The PCB 10 is made of plastic, glass, quartz, cystal, crystal glass or the like as shown in the enlarged views (a) and (b) And an optical filter 12 for filtering and focusing the light emitted from the light source 12 and emitting the light through the light outlet 21.

 As shown in the enlarged views (a) and (b) of FIG. 1, the light source 11 installed on the PCB 10 is made of a reflector or a reflective film, And a reflector 13 for reflecting the light toward the exit 21 is further provided.

The body 20 accommodates the PCB 10 therein, and a light outlet 21 is formed in a front part of the body 20 for intensively irradiating a treatment light to the treatment area of the body. The body 20 is cylindrical as shown in FIG. 1, but is not limited to the present invention. The body 20 may be formed into various shapes such as patches, hemispheres, urns, ellipses, and hearts. The body 20 can be used in a state where it is attached to the color light therapy site of the body by the double-sided adhesive tape 20a, the hydrogel pad 20b, the air adsorption plate 20c, or the like.

FIG. 6 shows a wired and cylindrical beam irradiator, but it is not intended to limit the present invention. Therefore, it goes without saying that various light beam irradiators such as a wireless type light beam irradiator can be employed. In addition, the present invention is not limited to the above-mentioned Korean Patent Publication No. 10-2012-0131316, Korean Patent No. 10-1225135, Korean Patent Publication No. 0-2016-0049097, Korean Patent Publication No. 10-2016-0054423, It is needless to say that the light beam therapy apparatus described in Korean Patent No. 10-1225135 can also be applied.

 7 is a block diagram showing the configuration of an apparatus for inducing cerebral blood circulation enhancement of the present invention.

The light irradiation control device 500 includes a display unit 530, an operation processing unit 550, a wireless transceiver unit 510, a power supply unit 590, a key input unit 520, a memory unit 560, 590).

It is possible to set the key input unit 520 to start / stop driving the light beam irradiator 200, or to set the setting data treatment time, the treatment intensity, the treatment mode (setting of one treatment or periodic treatment, etc.).

For example, when the light irradiation switch of the key input unit 520 is turned on, the arithmetic processing unit 550 outputs the light irradiation control signal so that the light beam is emitted during the light irradiation time determined by the light irradiation apparatus 200 , The arithmetic processing unit 550 automatically outputs a light beam end signal to stop the light beam from the light beam irradiator 200 after the predetermined light beam irradiation time has elapsed.

For example, if the light irradiation switch of the key input unit 520 is pressed and held for 3 seconds or longer, or if the periodic treatment mode switch is selected (turned on), a predetermined time interval (for example, Every 8 hours or every 6 hours), a light beam is emitted from the light beam irradiator for a predetermined light irradiation time, and a light irradiation end signal is automatically output after a predetermined light irradiation time has passed to cause the light beam to stop emitting light . By doing so, it is possible to automatically and periodically perform phototherapy to a pet or a patient who can not move the body.

The calculation processing unit 550 generates a light beam irradiation control signal in accordance with the setting data (treatment time, treatment intensity, etc.) received from the key input unit 520 and transmits the light beam irradiation control signal to the light beam irradiation control unit 500 through the transmission / And transmits it to the irradiation device 200. Here, the transmitting / receiving unit 510 of the beam irradiation control apparatus 500 and the transmitting / receiving unit 210 of the beam irradiation apparatus 200 may be a wired transmitting / receiving unit comprising a wired transmitting / receiving port or a wireless transmitting / receiving unit.

The calculation processing unit 550 stores the setting data (treatment time, treatment intensity, etc.) in the memory unit 560.

 The power supply unit 590 is a power supply unit for power used in driving the light beam control device 500. The light beam irradiator 200 receives power from the power supply device 590 of the light beam irradiation control device 500 and outputs the light beam to the light beam irradiating control device 500. In the case where the light beam irradiation control device 500 and the light beam irradiator 200 are made of wire, The irradiator 200 can be driven, and in this case, the battery 290 can be omitted.

The light beam irradiator 200 may include a transceiver 210, a controller 250, a light source driver 260, a light source 270, and a battery 290.

The control unit 250 of the light beam irradiator 200 drives the light source driver 260 to the light beam irradiation control signal received from the light beam irradiation control unit 500 through the transceiver unit 210 of the light beam irradiator 200, (270) is turned on or off.

The transmitting and receiving part 210 of the light beam irradiator 200 may be mounted on the attaching device 300 or the transmitting and receiving part 210 and the control part 250 of the light beam irradiating device 200 may be mounted on the attaching device 300. [ have.

In order to confirm the performance of the device for inducing cerebral blood circulation enhancement of the present invention, two experiments were conducted. The following two experiments and the results are described below.

As a first experiment, the present inventors conducted experiments to confirm that brain blood circulation is induced by relaxation of blood vessels of the brain by using an apparatus and method for inducing cerebral blood circulation enhancement according to the present invention. The animals used in the experiment were normal mice (C57BL6 mice, age = 20 weeks, n = 5), the wavelength of light used was 610nm, the intensity of light was 1.4mW / cm2 and the light irradiation time was 20 minutes. In order to confirm the vascular relaxation and blood flow changes in the in vivo animals before and after the light stimulation, an experimental animal was placed on a two-photon laser scanning microscope for animals, and the VA (vertebral artery) A light irradiation probe was attached and given a light stimulus. For the microscopic images, the animals were opened with skulls, covered with a transparent and flexible PDMS film, covered with the cerebral cortex, and placed under the microscope objective lens to perform the angiographic imaging before and after the light stimulation.

FIG. 8 is a graph showing the result of a cerebral angiogram before and after a light stimulus applied to an animal using an apparatus and method for inducing cerebral blood circulation enhancement according to the present invention. In FIG. 8, It's a blood vessel image. The right image is the brain blood vessel image of the animal after the light stimulus experiment.

As shown in FIG. 8, it was confirmed that the cerebral blood vessels relaxed before and after the light-stimulated stimulation to induce the blood circulation enhancement of the brain.

FIG. 9 is a graph showing the degree of vascular relaxation according to the diameter of blood vessels before and after light stimulation in an animal using an apparatus and method for inducing cerebral blood circulation enhancement according to the present invention. That is, FIG. 9 shows blood vessel diameters measured before and after stimulation according to blood vessels (0 to 5 um, 5 to 10 um, and 10 to 20 um) having different thicknesses.

As shown in FIG. It was confirmed that cerebral blood vessels relaxed evenly in vessels of all sizes such as capillary, pre-capillary artery, and arteriole. These results confirmed that the capillary blood vessels were particularly more relaxed.

As a second experiment, the present inventors confirmed SPECT imaging of cerebral blood circulation enhancement induced by relaxation of cerebral blood vessels in a normal person (n = 10) using an apparatus and method for inducing cerebral blood circulation enhancement according to the present invention The test was conducted.

10 is a graph showing an experimental protocol in which cerebral blood circulation is induced by relaxation of cerebral blood vessels in a normal person by using an apparatus and a method for inducing cerebral blood circulation enhancement according to the present invention and results of experiments .

Each subject took a total of 3 SPECT images by this protocol. However, taking the time taken for the contrast agent to be administered for SPECT to be taken out, it was taken again after 24 hours. Three SPECT images were defined as Control, CA, and VA according to the stimulation method. Here, Control is the case without light stimulation, CA is with Carotid Artery stimulation, and VA is with vertebral artery stimulation.

Before SPECT, subjects were stabilized for 10 minutes. The subjects waited on the table while lying on the table and started the light stimulation (0 min). After about 15 minutes, the HMPAO contrast agent was administered for SPECT. SPECT imaging was started 5 minutes after contrast injection. Twenty - four tomographic images were taken for approximately 15 minutes.

   FIG. 10 (a) is a SPECT image obtained by calculating the difference between the CA stimulus image and the control image acquired from the same subject and displayed on a 3D model. There were local changes in blood flow in the frontal lobe and occipital lobe.

FIG. 10 (b) shows that there is a change in the blood flow in the whole brain region as a result of the SPECT experiment in which the difference between the VA stimulated image and the control image is expressed in the 3D model.

The present invention relates to a method for alleviating, treating or preventing diseases such as vascular dementia, Alzheimer's disease, Parkinson's disease, stroke, migraine and depression, which are closely related to cerebral circulation, Can be applied.

The present invention can be applied to mitigate, treat or prevent various diseases closely related to cerebral circulation such as dementia, Parkinson's disease, stroke, migraine and depression.

The apparatus and method for inducing cerebral blood circulation enhancement according to the present invention described above are not limited to the above-described embodiments, and various modifications and changes may be made without departing from the scope of the present invention. There is a technical spirit to the extent that anyone can make various changes.

10: PCB 1 1: Light source
12: optical filter 13: reflector
20: Body 20 (a): Double-sided adhesive tape
20 (b): hydrogel pad 20 (c): air adsorption plate
21: light outlet 30: wire
40: Power jack 60: Laryngeal projection
70: median 71: carotid artery
72: Vertebral artery 100: Device for inducing cerebral blood circulation enhancement
200: Light beam irradiator 210: Transmitting /
250: control unit 260: light source driving unit
270: light source 290: battery
300: Attachment device 400: Cable
500: light irradiation control device 510: transmitting /
520: key input unit 530:
550: Operation processing unit 560:
590: Power supply

Claims (18)

A light source, which irradiates light to the carotid artery counterpart or the vertebral artery counterpart, which is the skin surface of the neck of the neck where the carotid and vertebral arteries supply blood and oxygen to the brain, An irradiator;
A light beam irradiation control device for generating and transmitting a light beam irradiation control signal in accordance with setting data including a light irradiation time;
Wherein the device is adapted to induce cerebral blood circulation enhancement. The method according to claim 1,
The light beam irradiator stimulates nerve endings distributed in the skin layer or the dermal layer below the skin surface of the carotid artery corresponding part or the vertebral artery corresponding part by irradiating light for a predetermined light irradiation time, In nitrergic nerve terminals connected to the terminal and nervous system, it induces secretion of substances containing nitric oxide,
Wherein the secreted material relaxes the cerebral blood vessels and the lymph vessels in contact with the nitrogen active nerve endings to induce the enhancement of cerebral blood circulation. 3. The method of claim 2,
The light beam irradiator,
Nerve Activation of the cerebral blood circulation by relaxation of the cerebral blood vessels and lymph vessels in contact with the active nerve terminals leads to damage to the injured cells functioning as a brain clearance system such as astrocyte, To enhance the supply and slowly restore function of the damaged brain cleansing system to emit visible light to inhibit the accumulation of amyloid beta plaques,
Is controlled by a light beam irradiation control device so as to emit the visible light for a set light exposure time and to automatically terminate visible light emission when the set light exposure time is ended. The method according to claim 1,
The light beam irradiation control device wirelessly transmits the light beam irradiation control signal to the light beam irradiator,
A device for inducing cerebral blood circulation enhancement, characterized in that the light beam irradiator incorporates a battery. The method according to claim 1,
The light beam irradiation control device transmits the light beam irradiation control signal to the light beam irradiator,
Wherein the light beam irradiator is driven by a power source transmitted from the light beam irradiation control device. The method according to claim 1,
Wherein the carotid-artery corresponding portion is a position of an occipital blood in a neck portion of a person or an animal. The method according to claim 1,
Wherein the vertebral artery corresponding portion is a position of the cervical or air haemostasis in the neck of a person or an animal. The apparatus according to claim 1,
When the straight distance from the earlobe to the vertical line from the earlobe to the midline or laryngeal protrusion on the left or right side of the neck or the laryngeal protrusion (Adam's Apple) on the front of the neck is referred to as "frontal midline-earlobber distance".
Wherein the clip is mounted between the midline or laryngeal protuberances from a half of the frontal midline to the earlobe distance to a two third of the frontal midline to the earlobe distance. The apparatus according to claim 1,
When the straight line distance from the back of the neck to the vertical line from the earlobe to the midline to the midline, from the left and right to the midline or Adam's Apple, is referred to as "rear midline-earlobber distance".
And is mounted from the midpoint to the midpoint of the back midpoint to the earlobe, to the midpoint of the back midpoint to the earlobe of the earlobe. The method according to claim 1,
Wherein the light source is a combination of one or more of LEDs or OLED or micro LEDs. The method according to claim 1,
The light beam irradiator is configured to emit a light beam having a peak wavelength of 590 nm to 620 nm and a light intensity of 1 mW / cm 2 to 5 mW / cm 2, . The method according to claim 1,
The apparatus for inducing cerebral blood circulation promotion, further comprising an attaching device for attaching a light beam irradiator to an animal or a person so as to irradiate light to the light beam irradiator carotid corresponding part or the vertebral artery corresponding part. 13. The method of claim 12,
Wherein the attaching device is one of a double-sided tape, an absorbing tool, a head gear, a necklace, and a collar. The method according to claim 1,
Wherein the light beam irradiator is configured to emit a light ray for 10 to 20 minutes in order to stimulate the carotid artery counterpart or vertebral artery counterpart once. The method according to claim 1,
Wherein the light beam irradiation control device is one of a smart phone, a PDA, a notebook, an Android phone, an iPhone, a smart watch, and a computer. The method according to claim 1,
Wherein the light beam irradiator further comprises a light ray filter. The method according to claim 1,
When the periodic treatment mode switch provided in the light beam irradiation control device is selected,
Characterized in that the light beam irradiation control device generates a light beam irradiation control signal so that the light beam irradiator emits a light beam for a predetermined light irradiation time every predetermined time interval and transmits the light beam irradiation control signal to the light beam irradiator / RTI > 14. The method of claim 13,
Wherein the light irradiation control device or the light irradiation device is embedded in the attaching device when the attaching device is one of a headgear, a necklace, and a necklace.

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