KR20190054813A - Feed composition for reducing food allergy comprising mealworm and use thereof - Google Patents

Abstract

The present invention relates to a feed composition for preventing or reducing food allergies, comprising mealworms; a method for preventing or reducing food allergies in companion animals using the same; and a method for preparing a feed composition for preventing or reducing food allergies. According to the present invention, food allergies of companion animals can be prevented or reduced only by feed, thereby improving the quality of life of companion animals.

Description

[0001] The present invention relates to dietary allergen reducing feed compositions comprising brown goats and their use,

The present invention relates to a dietary allergy reducing feed composition comprising brown goats and their use. More particularly, the present invention relates to a dietary allergy preventive or abstinence dietary composition comprising brown goats that can reduce dietary allergies of companion animals and uses thereof.

As the number of independent households increased by one or two due to aging, low fertility, and divorce, the domestic dog market has been growing by 15-20% every year since 2000 and the pet population has reached 10 million.

Recently, there have been a lot of people who invest in livestock animals with their pets being changed into 'companion animals', which are family members living together. Therefore, it is expected that the market related to companion animals will continue to expand without being significantly affected by the economy or income. In particular, the pet food market is estimated to reach 340 billion.

Consumption trends of companion animal feeds can be largely divided into natural raw materials and functional pursuits. Natural raw material tendency refers to the tendency of companion animals to find feeds that use healthy raw materials that can be eaten by humans, as well as humans, as they begin to grow companion animals as family members. The pursuit of functionality means pursuing functional products that prevent companion disease in order to keep companion animals healthy for a long time.

Consumption trends of these animal feeds are expected to accelerate.

On the other hand, it is known that inflammatory skin diseases diagnosed in companion animals account for 10 ~ 15% of dietary diseases. Especially in dogs, diarrheal diseases among nonseasonal dermatitis have been reported to occupy 20 ~ 35%. Dietary allergy is a disease caused by dietary factors and has a great impact on the quality of life of companion animals.

Background Art [0002] As a background art of the present invention, Korean Patent Laid-Open No. 10-2013-0079026 (Jul. 10, 2013) describes a first mixing step (S1) in which egg whites are mixed with distilled water at a certain ratio (S1): vitamins, fructooligosaccharides, (S2): aging step for aging the secondary mixed liquid raw material (S3): aging the aged liquid raw material into primary raw materials (1), (2), Primary coating step (S4) for mixed coating of manufactured extruded feeds: Powder raw materials such as phosphorus, calcium, carrot, apple, strawberry, tomato, banana, coconut, (S5): drying the second coated raw material (S6), and a method of manufacturing a dog feed made therefrom.

A number of patent documents are referenced and cited throughout the present invention. The disclosures of the cited patent documents are hereby incorporated by reference into the present invention in its entirety to better illustrate the state of the art to which the present invention pertains and the content of the present invention.

It is an object of the present invention to provide a feed composition for the prevention or alleviation of dietary allergies comprising brown goats.

It is another object of the present invention to provide a method for preventing or reducing dietary allergy in a companion animal using a feed composition comprising a brown goat.

It is still another object of the present invention to provide a method for preparing a feed composition for preventing or reducing dietary allergy of the companion animal.

Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims and drawings.

According to one aspect of the present invention, there is provided a dietary composition for preventing or reducing dietary allergies, which comprises brown gill as an active ingredient.

According to an embodiment of the present invention, the brown gourd may be included in an amount of 20 to 50 parts by weight.

According to one embodiment of the present invention, skin eruption, hyperpigmentation, swelling, or feeling of leaning can be reduced.

According to one embodiment of the present invention, the amount of percutaneous water evaporation can be reduced.

According to one embodiment of the present invention, the brown gourd may be a defatted larva.

According to one embodiment of the present invention, a soybean paste comprising 20 to 50 parts by weight of brown rice, 3 to 5 parts by weight of potato starch, 1 to 3 parts by weight of linseed, 3 to 10 parts by weight of tallow, 1 to 3 parts by weight of soybean oil, And 1 to 3 parts by weight of fructooligosaccharide.

According to one embodiment of the present invention, one or more of vitamins and minerals may be further included.

According to one embodiment of the present invention, it may be for dog or cat feed.

According to one aspect of the present invention, there is provided a method for preventing or reducing dietary allergy in a companion animal, comprising feeding the compost animal with the dietary composition for preventing or reducing allergy.

According to one embodiment of the present invention, a feed composition for preventing or reducing dietary allergy can be fed for 4 weeks or more.

According to one aspect of the present invention, there is provided a method of preparing a dietary allergy prevention or abatement feed composition, comprising mixing 20 to 50 parts by weight of a brown goat with a feed composition.

According to one embodiment of the present invention, the feed composition comprises 20 to 50 parts by weight of brown rice, 3 to 5 parts by weight of potato starch, 1 to 3 parts by weight of linseed, 3 to 10 parts by weight of soybean curd, And 1 to 3 parts by weight of fructooligosaccharide.

According to one embodiment of the present invention, the feed composition may further include at least one of vitamins and minerals.

According to one embodiment of the present invention, dietary allergy of the companion animal can be prevented or reduced.

According to one embodiment of the present invention, dietary allergies of the companion animal can be prevented or reduced only by the feed, and the quality of life of the companion animal can be improved.

According to one embodiment of the present invention, it is possible to economically and easily produce a functional food composition for preventing or reducing dietary allergy of a companion animal having a history of food and feeling of well-being.

FIG. 1A is a graph showing the degree of leaning sensation in evaluation of PVAS of dietary allergy patients. FIG.
FIG. 1B is a view showing 20 body parts (red color) to be evaluated in CADESI-4-scoring.
FIG. 2 is a photograph showing the result of reduction of skin eruption, hyperpigmentation lesion, and edema according to the feeding of dietary composition for preventing or reducing dietary allergy according to one embodiment of the present invention.
FIG. 3 is a graph showing the results of decreasing the amount of percutaneous water evaporation according to the feed composition for prevention or alleviation of dietary allergy according to an embodiment of the present invention.
FIG. 4 is a graph showing the result of the feeding of the feed composition for prevention or reduction of dietary allergy according to one embodiment of the present invention to a subject having dietary allergy, without deteriorating the feeling of well-being.
FIG. 5 is a graph showing the results of not exerting a skin lesion even when dietary allergy-preventing or reducing feed composition according to an embodiment of the present invention is fed to a subject having dietary allergy.
FIG. 6 is a graph showing that there is no need for an increase in the amount of the drug because the dietary allergy preventive or reducing dietary composition according to an embodiment of the present invention is fed to an individual having dietary allergy without aggravating skin symptoms and pruritus.

BRIEF DESCRIPTION OF THE DRAWINGS The present invention is capable of various modifications and various embodiments, and specific embodiments are illustrated in the drawings and described in detail in the detailed description. It is to be understood, however, that the invention is not to be limited to the specific embodiments, but includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in detail with reference to the accompanying drawings. Hereinafter, the present invention will be described in more detail.

According to one aspect of the present invention, there is provided a dietary composition for preventing or reducing dietary allergies, which comprises brown gill as an active ingredient.

In the present invention, " brown dagger " means an insect belonging to arthropod insect beetle's mealworm beetle. The body of the brown duck is dark brown and the length is about 15mm insect called brown rice duck. Adults usually lay eggs in grains, which hatch after 1 to 2 weeks, and the hatched larvae are called mealworms. The larvae are pupae after 9 ~ 20 times of molting, become alienated (adult), are nocturnal and distributed all over the world.

The wheat worms are cultivated in large quantities by feeding on birds and hedgehogs. In addition, protein and fat content is high and cheap, and it is evaluated as high value as food raw material, and it is attracting attention as future food resource.

In the present invention, " dietary allergen " means a disease that causes a pruritus due to ingestion of one or more ingredients in feed or food regardless of season. The antigens responsible for dietary allergens of companion animals are beef, beans, dairy products, and cereals, and cat is known to be beef, milk, and fish.

Dietary allergies are similar to atopic dermatitis, but are distinguished from seasonal atopic dermatitis in that the clinical manifestations are different and non-seasonal. In addition, allergic reactions to anti-inflammatory drugs (corticosteroids) are weak in dietary allergies, while inflammatory skin diseases such as atopy are known to be highly reactive.

Dietary allergies are mainly due to the immunogenicity and permeability of the dietary protein source to the gut, leading to an allergic mechanism. Therefore, it is a disease that can be treated only through the feed. In addition, dietary allergy is a disease that can be diagnosed and treated with difficulty only by a food trial.

However, it is known that the mechanism of the onset of allergic diarrhea is completely unknown, and immediate reaction (Type Ⅰ) or delayed reaction (Type Ⅲ or Ⅳ) occurs for specific ingredients.

In accordance with the present invention, it is possible to prevent or reduce dietary allergies of companion animals by incorporating a brown gourd as a protein source in the feed composition. That is, it is possible to improve the quality of life of companion animals by improving related symptoms such as percutaneous moisture evaporation, cannibalism, and dermatitis of companion animals (see FIGS. 1 to 6).

According to one embodiment of the present invention, the dietary composition for preventing or reducing dietary allergies according to the present invention can reduce skin redness, hyperpigmentation, swelling, or feeling of leaning (see FIG. 2).

According to one embodiment of the present invention, the feed composition for preventing or reducing dietary allergy of the present invention can reduce the amount of percutaneous water evaporation (see FIG. 3).

According to an embodiment of the present invention, the brown gourd may be included in an amount of 20 to 50 parts by weight.

If the brown gourd is contained in less than 20 parts by weight of the feed composition, the dietary allergen may not be prevented or reduced. If the brown gourd is contained in an amount exceeding 50 parts by weight, And the overall nutritional imbalance of the feed composition may occur.

According to one embodiment of the present invention, the brown gourd may be a defatted larva.

However, in the case of defatted larvae, the dietary allergy prevention or reduction effect can be improved and the production cost can be lowered.

According to one embodiment of the present invention, the dietary composition for preventing or reducing dietary allergies according to the present invention comprises 20 to 50 parts by weight of brown rice, 3 to 5 parts by weight of potato starch, 1 to 3 parts by weight of linseed, 10 to 10 parts by weight, 1 to 3 parts by weight of soybean oil, and 1 to 3 parts by weight of fructooligosaccharide.

By way of example, but not by way of limitation, dietary allergies may be prevented or reduced while the nutritional balance of the overall feed composition is met.

According to one embodiment of the present invention, the feed composition for preventing or reducing dietary allergies according to the present invention may further comprise at least one of vitamins and minerals. Although not limited thereto, the vitamins and minerals may be added to the feed composition in an amount of 0.1 to 10 parts by weight.

According to one embodiment of the present invention, the feed composition for preventing or reducing dietary allergy of the present invention may be used for dog or cat feed. But the present invention is not limited thereto. The feed composition for preventing or reducing dietary allergy of the present invention may be applied to various companion animals such as dogs and cats.

The feed composition of the present invention may further comprise a functional material.

The functional material may be selected from the group consisting of DHA, EPA, aloe, squalene, corn beard, Garcinia cambogia, hibiscus, bamboo leaf, chlorella, spirulina, leek, green tea, roundworm, persimmon leaf, mulberry leaf, brown rice, barley, rooibos, Any one or more selected can be used. The functional material may be added in an amount of 0.1 to 10 parts by weight based on the total weight of the feed composition.

The feed composition of the present invention may further comprise ingredients added to conventional feed compositions. Examples of ingredients added to such a feed composition may include cereal powders, meat powders, beans, and the like.

The cereal powder may be at least one selected from rice flour, wheat flour, barley flour, and corn flour. However, the dietary supplement is added in a minimum amount to the extent that it does not cause allergy.

In the above, the meat powder may be meat powder obtained by pulverizing at least one selected from chicken, beef, pork, and ostrich meat. However, the dietary supplement is added in a minimum amount to the extent that it does not cause allergy.

At least one selected from soybean, kidney bean, pea, and black bean can be used. However, the dietary supplement is added in a minimum amount to the extent that it does not cause allergy.

The feed composition of the present invention may be supplemented with at least one selected from nutrients and minerals to increase nutrition of the feed in addition to cereal powder, meat powder, and pulp, which are added to the above-mentioned conventional feed composition, It may contain one or more selected from antifungal agents, antioxidants, anticoagulants, emulsifiers, and binders to prevent deterioration of quality.

The components of the conventional feed composition mentioned above can be selected by a person skilled in the art and are somewhat different from essential constituents in the present invention, and therefore, detailed description thereof will be omitted in the present invention.

According to one aspect of the present invention, there is provided a method for preventing or reducing dietary allergy in a companion animal, comprising feeding the companion animal a dietary composition for preventing or reducing dietary allergy of the present invention.

According to one embodiment of the present invention, the feed composition for preventing or reducing dietary allergy of the present invention can be fed for 4 weeks or more.

According to one embodiment of the present invention, the companion animal may be a companion animal having a history of food or feeling of well-being.

The present invention can effectively improve dietary allergy in a short time even in the case of a companion animal having a previous history of food and feeling of well-being.

The feed composition of the present invention can be fed to companion animals in the same manner as the feeding of a general feed composition.

The feeding condition for feeding the feed composition of the present invention to the companion animal can be selected by a person skilled in the art and is not an essential component in the present invention. .

According to one aspect of the present invention, there is provided a method of preparing a dietary allergy prevention or abatement feed composition, comprising mixing 20 to 50 parts by weight of a brown goat with a feed composition.

The method for preparing a feed composition of the present invention can be formulated into a feed form according to a method such as extrusion molding by additionally mixing the feed composition with ordinary feed ingredients according to a conventional method.

According to one embodiment of the present invention, the feed composition of the present invention comprises 20 to 50 parts by weight of brown rice, 3 to 5 parts by weight of potato starch, 1 to 5 parts by weight of linseed 1 3 to 10 parts by weight of tallow, 1 to 3 parts by weight of soybean oil, and 1 to 3 parts by weight of fructooligosaccharide.

According to one embodiment of the present invention, the feed composition of the present invention may further comprise one or more of vitamins and minerals in the method for preparing a dietary composition for preventing or reducing dietary allergy. Although not limited thereto, the vitamins and minerals may be added to the feed composition in an amount of 0.1 to 10 parts by weight.

Hereinafter, the present invention will be described in detail with reference to examples. It should be understood, however, that these examples are provided for illustrative purposes only and are not to be construed as limiting the scope of the present invention.

Example

Materials and methods

Selection of evaluation subjects

The subjects of this study were dogs who were diagnosed as food allergy among the dogs visited at Chungbuk National University Animal Medical Center due to their skin symptoms including history of food and pruritus.

Manage the evaluation subject

The low-allergenic feeds previously supplied to all subjects were discontinued and feed compositions according to the present invention were fed.

As a comparative example of hypoallergenic feed, a hydrolyzed salmon was used as a main protein source in the case of the test feed A, and in the case of the test feed B, a brown goat larva (defatted) was used.

Oral medicines and medicated shampoos used in existing prescription allergy treatments were used continuously.

The blending ratios of Examples and Comparative Examples according to the present invention are shown in Table 2.

Evaluation index

(One) Transepidermal  water loss ( TEWL , Percutaneous moisture evaporation )

TEWL is an internationally recognized method of assessing the amount of water evaporating through the skin and indirectly indicative of dysfunction due to lack of the outer lipid layer.

The higher the number, the greater the degree of dysfunction of the skin lipid layer.

(2) Pruritus Visual Analogue Scale ( PVAS )

PVAS is an internationally recognized assessment method for evaluating the feelings of a patient.

According to the above-mentioned evaluation method, the degree of leaning felt by the guardian of the dog was evaluated in the range of 0 to 10 points

As shown in Fig. 1A, evaluation was made from not scratching (0 point) to extremely scratching (10 points).

(3) Canine Atopic  Dermatitis Extent and Severity Index ( CADESI ) -04

CADESI is an internationally recognized assessment method for the clinical assessment of skin conditions in dogs with atopic dermatitis.

Atopy can be used to evaluate dietary allergies and dietary allergic skin symptoms.

 The range of 0-180 points was used to quantify the overall condition of the skin including redness, flaccidity, alopecia, and autogenous lesions.

The higher the score, the worse the skin condition.

Specifically, three fields of the 20 area of skin (Fig. 1b) [redness (erythema), lichen Chemistry (lichenification), self-wound (excoriation) / hair loss (alopecia)] 4 rating against asymptomatic (0 points), poor ( 1 point), average (2 points), and severity (3 points).

Give a score ranging from a minimum of 0 points (no symptoms) to a maximum of 180 points (all symptoms are severe).

(4) Medication score

The medication score is a measure of the relative change in the dose of prescription drugs before and after the application of a hypoglycemic diet when the drug is continuously applied to the allergic skin disease during clinical evaluation.

The relative amount of change was measured by setting the basic dose used as the maintenance dose to 1 for allergy treatment.

Prednisolone 0.5 mg / kg sid, Oclacitinib 0.4 mg / kg sid and Cyclosporin 5 mg / kg sid were set as the basal doses.

Results and Discussion

(1) Component analysis results

Table 3 shows the results of analyzing the components of the feed composition including the brown gourd according to the blending ratio shown in Table 2. < tb > < TABLE >

(2) Observation of clinical symptoms

Reduced skin eruptions between the toes, decreased abdominal hyperpigmentation, decreased edema of the auricle (see FIG. 2).

(3) Transepidermal  water loss ( TEWL , Percutaneous moisture evaporation )

Both groups showed an effect of reducing the amount of transdermal water evaporation (see FIG. 3).

This is because the ingredients in the feed supplement the skin's lipid layer or restore the function of the lipid layer with some reduction in skin inflammation and leaning.

(4) Pruritus Visual Analogue Scale ( PVAS )

In the case of allergic feed A group, a decrease in pruning was observed in one out of three, but no change in pruning was observed in all groups in group B.

No worsening of pruritus was observed even though two new feeds were fed from all individuals with dietary allergy (see FIG. 4).

(5) Canine Atopic  Dermatitis Extent and Severity Index ( CADESI ) -04

In the hypoglycemic group A, skin lesions decreased in 2 out of 3 individuals and increased in 1, but in group B, improvement was observed in 1 and in 2.

The change in individuals with increased skin lesions was 6 points for group A, 3 points for group B, and 2 points for worsted score of 180 points.

Therefore, it was judged that neither of the two feeds would exacerbate skin lesions (see FIG. 5).

(6) Medication score

For the hypoglycemic feed A group, a decrease in the drug dose was observed in one and not in the other two.

In group B, there was no change in dose of drug in all subjects.

This indicates that neither of the two feeds caused skin symptom and nuisance deterioration and there was no need for a dose increase (see FIG. 6).

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit of the invention as set forth in the appended claims. The present invention can be variously modified and changed by those skilled in the art, and it is also within the scope of the present invention.

Claims (14)

A dietary composition for preventing or reducing diarrhea allergy, comprising as an active ingredient a brown goat.
The method according to claim 1,
Wherein the brown gourd is contained in an amount of 20 to 50 parts by weight.
The method according to claim 1,
A composition for preventing or reducing dietary allergy, which reduces skin eruption, hyperpigmentation, edema, or pruritus.
The method according to claim 1,
A dietary composition for preventing or reducing dietary allergy, which reduces the amount of transdermal water evaporation.
The method according to claim 1,
The brown gourd is a defatted larva, the feed composition for preventing or reducing dietary allergy.
The method according to claim 1,
20 to 50 parts by weight of brown rice, 3 to 5 parts by weight of potato starch, 1 to 3 parts by weight of linseed, 3 to 10 parts by weight of wax, 1 to 3 parts by weight of soybean oil and 1 to 3 parts by weight of fructooligosaccharide Wherein the dietary allergy preventive or reducing dietary composition is used.
The method according to claim 1,
Wherein the composition further comprises at least one of a vitamin and a mineral.
The method according to claim 1,
A feed composition for the prevention or alleviation of dietary allergies for dog or cat food.
9. A method for preventing or reducing dietary allergy in a companion animal, comprising feeding a companion animal with a dietary composition for preventing or reducing dietary allergy according to any one of claims 1 to 8.
10. The method of claim 9,
A method for preventing or reducing allergic dietary allergies in a dietary allergy preventive or abstinence dietary composition for at least 4 weeks.
10. The method of claim 9,
Wherein said companion animal is a companion animal having a history of food or feeling of well-being.
And 20 to 50 parts by weight of a brown goat in a feed composition. ≪ RTI ID = 0.0 > 21. < / RTI >
13. The method of claim 12,
The feed composition comprises 20 to 50 parts by weight of brown rice, 3 to 5 parts by weight of potato starch, 1 to 3 parts by weight of linseed, 3 to 10 parts by weight of wax, 1 to 3 parts by weight of soybean oil, 3 parts by weight of a composition for preventing or reducing dietary allergies.
13. The method of claim 12,
Wherein the feed composition further comprises one or more of vitamins and minerals.

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