KR20190001382A - In Vitro Maek-producing System for Pulse Standardization - Google Patents

Abstract

The present invention relates to an in vitro pulsation regeneration system which instrumentally regenerates a pulsation, which is one of medicine diagnosis methods, the system comprising: an artificial blood vessel forming a closed circulation system in which a fluid can circulate; a pulse generation unit installed on one side of the artificial blood vessel to form a specific section of the artificial blood vessel as an artery section in which a pulse exists, and to generating a pulse in the artificial blood vessel; a pulse removal unit installed on an arbitrary position of the artificial blood vessel to form a specific section of the artificial blood vessel other than the artery section as a vein section without a pulse; a pulsation observation unit formed in the artery section of the artificial blood vessel to observe various pulsation waves of a human body regenerated by the pulse generation unit; a blood pressure/body fluid adjusting unit for adjusting blood pressure or a body fluid to adjust blood pressure of a fluid circulating inside the artificial blood vessel by injecting a fluid into the artery section or to observe a change in a pulsation according to a change in a body fluid in blood by exchanging a fluid circulating inside the artificial blood vessel; and a control unit connected to the pulse generation unit to control the size, speed or interval of the pulse by an input of a user. Therefore, the present invention can instrumentally regenerate a pulsation of a human body, secure a standard pulsation system, and help to improve a pulsation diagnosis ability of a learner or an Oriental doctor by using a standardized pulsation, thereby objectifying diagnosis evaluation of an Oriental doctor and enhancing the accuracy of a pulsation diagnosis.

Description

[0002] In Vitro Maek-producing System for Pulse Standardization [

[0001] The present invention relates to an In Vitro (In Vitro) Mac Reproduction System that reproduces a Mac, which is one of the diagnostic methods of Oriental Medicine. More particularly, the present invention relates to a system for reproducing a Mac of a human body, The present invention relates to an in vitro macroreproduction system that helps improve the ability of a learner or a therapist to improve the pulse strength of a lecturer, thereby objectifying the diagnostic evaluation of the lecturer and increasing the accuracy of the laparoscope.

In the oriental medicine, the vein method is a method of diagnosing the patient through the grasping of the artery of the radial artery in the wrist area of the patient, and it is a method of diagnosing the patient by using the characteristics of the veins such as buckets, spikes, And the other is the relative nature of the pulse.

Although this method is a very important diagnostic method in the diagnosis of the oriental medicine such as the determination of the condition of the patient, the nature of the disease, and the treatment method, it depends on the personal finger sense of the oriental medicine doctor, And may lead to other diagnostic results depending on the sense or experience of the Chinese medicine doctor, which may lower the reliability of the diagnosis.

In other words, the base line of Oriental medicine can be different according to the person and the degree of skill of the oriental medicine. Therefore, there is a need to improve the ability of the oriental medicine to improve the accuracy of the results.

However, there are many variables such as age, skin, etc. in vivo. In order to objectify it, more than 100 patients are needed per macroscopically, and when 28 macros are considered, The number of patients should be ensured, which is not feasible when considering a single patient population.

Therefore, although a device for improving the venous capacity has been developed in the prior art, the conventional device is a technique to reproduce a pulse wave by using artificial vibrations, and thus is not substantially helpful to the oriental medicine practitioner.

In addition, although a pulse pulse gauge (a device for diagnosing a pulse wave) for measuring a human body has been developed, conventional pulse gauges have been difficult to objectify because there is no standard pulse wave for verifying accuracy or validity.

That is, if standardization of the macroscopic standard is not standardized in standardizing the pathology of oriental medicine, the standardization of the pathology will be limited. Therefore, the present applicant has repeatedly conducted researches on the development of a device It came to the following.

Korean Patent No. 10-1005372.

SUMMARY OF THE INVENTION The present invention has been made in order to solve the above problems, and it is an object of the present invention to provide a standardized Mac system in Oriental medicine by developing an in vitro Mac reconstruction system capable of reproducing a Mac in vitro, There is a purpose.

In addition, we have developed an in vitro vascular system capable of eliminating many in vivo variations and obtained interrelated basic data by comparing the diagnoses of ultrasonic Doppler, conventional pulse wave, and oriental medicine which can objectify them, The present invention is directed to a method and system for diagnosing a prognosis of a patient.

In addition, the standard of the Mac has been proposed, and it has been suggested that (1) the medical training and medical application of the clinical Chinese doctor, (2) the in vitro test standard of the existing pulse machine, and (3) The purpose is to provide.

In order to achieve the above object, according to the present invention, there is provided an artificial blood vessel which forms a closed circulation system in which a fluid can circulate, and an artificial blood vessel which is installed on one side of the artificial blood vessel so as to form a certain section of the artificial blood vessel, A pulsation generating unit for generating pulses in the artificial blood vessel and pulse eliminators provided at arbitrary positions of the artificial blood vessel so that a certain section of the artificial blood vessel is formed as a vein section without pulses in addition to the arterial section; A vein observation part formed in the artery part of the artificial blood vessel so as to observe various pulse waves of a human body reproduced by the generator part; and a control part for controlling the blood pressure of the fluid circulating in the artificial blood vessel by injecting fluid into the artery part, In order to observe the change of the veins according to the fluid change in the blood by exchanging the circulating fluid, A control unit including a blood pressure / body fluid adjusting unit for adjusting body fluid, and a program for controlling the size, speed, or interval of the pulse by a user's input, connected to the pulse generating unit through a computer interface unit An in-vitro Mac reconstruction system is provided.

In the present invention, a part of the artificial blood vessel may be wound inside the pulse generating unit to form a closed circulatory system, and the pulse may be generated by pressing the artificial blood vessel at a constant cycle in the pulse generating unit.

In this case, since a pulse is generated in the process of drawing the fluid into the pulse generating unit, the artificial blood vessel in the part where the fluid is drawn out from the pulse generating unit forms an artery section, Of the artificial blood vessel forms a vein section.

In addition, the artificial blood vessel may be formed of a silicone tube having a predetermined diameter, artificial blood vessels of biological or non-biological materials.

The pulse eliminator may be formed by providing a capillary between the arterial segment and the vein segment so as to distinguish the arterial segment in which the pulse is present and the non-pulse segment in the artificial blood vessel.

The blood pressure / body fluid regulator may include an injector for injecting a fluid into the arterial section, and an injector installed between the injector and the artificial blood vessel for selectively injecting liquid into the artificial blood vessel to exchange liquid in the artificial blood vessel, Way cock that allows the user to raise and lower the cuff.

In the present invention, the vein observing unit may further include an artificial skin that surrounds the artificial blood vessel and transmits pulses generated from the artificial blood vessel for pulse training.

In addition, an ultrasound device and a pulse generator may be further included to observe a vein in the arterial section of the artificial blood vessel to observe a virtual radial artery blood vessel.

According to the present invention as described above, an in vitro Mac reconstruction system capable of reproducing a Mac in vitro can be provided by standardizing a Mac, thereby providing a standardized Mac system in oriental medicine.

In addition, we have developed an in vitro vascular system capable of eliminating many in vivo variations and obtained interrelated basic data by comparing the diagnoses of ultrasonic Doppler, conventional pulse wave, and oriental medicine which can objectify them, (2) the in vitro test standard of the existing pulse oximeter, (3) the medical examination of the oriental medicine major, It can be applied to students' pulse training.

In addition, the industry will provide a standard to test existing pulse oximeters, significantly reducing the cost of clinical trials, reducing the burden on the enterprise and providing a standard that can be easily validated.

In addition, the in vitro Mac system can be utilized directly in the basic education field of Oriental medicine by objectifying the pulse-based diagnosis technology introduced in oral and apprentice education, and it is possible to utilize pulse-based diagnosis technology for clinical education by implementing a virtual Mac , Virtual patients and patient's pathology can be implemented to be used in various clinical cases of oriental medicine clinical education.

1 is a configuration diagram schematically showing a configuration of an in vitro macro-representation system of the present invention.
FIG. 2 is a perspective view showing a prototype of an in vitro Mac reconstruction system according to an embodiment of the present invention.
3 is an ultrasound image photograph showing that a vein is observed in an artificial blood vessel when the pulse generator is operated according to the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. It is provided to let you know.

FIG. 1 is a schematic diagram showing a configuration of an in-vitro Mac reconstruction system according to the present invention, and FIG. 2 is a perspective view showing a prototype of an in vitro Mac reconstruction system according to an embodiment of the present invention.

The present invention develops an 'in vitro Mac Reproduction System' for standardization of a Mac, and acquires interrelated basic data using a medical diagnosis, an ultrasonic Doppler image, and a commercial pulse generator for representative macroscopically produced macroscopically, And it is the first attempted technique in Oriental medicine field.

1, the present invention includes an artificial blood vessel 10, a pulse generating unit 20, a pulse removing unit 30, a blood pressure / body fluid adjusting unit 40, a control unit 50 ).

The artificial blood vessel 10 is a virtual blood vessel that virtually represents a human radial artery, and is formed so as to form a closed circulation system in which a fluid replacing blood can flow and circulate therein.

In the present invention, the artificial blood vessel 10 may be formed of a synthetic tube of a silicone tube, biological or non-biological material, and has an inner diameter ranging from 1 to 20 mm, and is preferably formed to resemble the radial artery of a human body.

The artificial blood vessel 10 is configured to form an arterial section 12 and a vein section 14 in a closed circulatory system. A certain section of the artificial blood vessel 10 is formed into an arterial section 12 in which pulses are present A pulse generator 20 is installed on one side of the artificial blood vessel 10.

The pulse generator 20 generates pulses in the artificial blood vessel 10 to constitute a certain section of the artificial blood vessel 10 as an artery section 12. In the present invention, A pulse is generated by forming a closed circulation system within the pulse generation unit 20 and by pressing the artificial blood vessel 10 at a predetermined period in the pulse generation unit 20.

Referring to FIG. 1, a structure capable of pressing the artificial blood vessel 10 is installed in the pulse generating unit 20, and the artificial blood vessel 10 is pressed at a constant cycle by the rotation of the structure, . In the drawings, the structure is provided so as to pressurize the artificial blood vessel 10 at three points, but this is merely to illustrate the present invention and is not intended to limit the present invention.

Since the pulse is generated in the process of drawing the fluid into the pulse generator 20, the artificial blood vessel 10 in which the fluid is drawn out from the pulse generator 20 forms the artery section 12 And the artificial blood vessel 10 in the portion where the fluid is introduced into the pulse generating unit 20 forms the vein section 14.

The pulse eliminator 30 is installed at an arbitrary position of the artificial blood vessel 10 so that a certain section of the artificial blood vessel 10 other than the arterial section 12 is formed as a vein section 14 having no pulse do.

The pulsation removing unit 30 is provided between the arterial section 12 and the vein section 14 so as to distinguish the artery section 12 in which the pulse is present from the vein section 14 without the pulse in the artificial blood vessel 10, A capillary tube may be provided. That is, by narrowing the diameter of the artificial blood vessel 10 to form a capillary, the pulse can be removed.

On the other hand, a vein observing section 12a is formed in the artery section 12 of the artificial blood vessel 10 so as to observe various pulse waves of the human body reproduced by the pulse generating section 20.

The vein observation unit 12a may be formed of the artificial blood vessel 10 itself or may be configured to surround the artificial blood vessel 10 so as to observe a vein in the same state as the human body, An artificial skin (not shown) for transmitting a pulse generated from the robot 10 may be further included.

At this time, the artificial skin may be a silicone material having a texture similar to that of an actual skin, or a living body tissue including skin, subcutaneous, and muscular layers so that the pulse feel like a real pulse during exercise.

The blood pressure / body fluid regulator 40 regulates the blood pressure of the fluid circulating in the artificial blood vessel 10 by injecting fluid into the arterial section 12 or exchanges the fluid circulating in the artificial blood vessel 10 (40) for injecting a fluid into the artery section (12), and an injector (40) for injecting a fluid into the artery section (12) And a 3-way cock (42) installed between the blood vessels (10) to selectively inject liquid into the artificial blood vessels to exchange liquid in the artificial blood vessels or to raise and lower blood pressure .

The injector 40 may be in the form of a conventional syringe. In other words, it is possible to inject an appropriate amount of blood according to the need of the experimenter, or to mix components (fat, plasma, sugar, etc.) contained in the blood with fluids at different concentrations depending on the purpose of the experiment, Can be applied.

The 3-way cock 42 is installed between the injector 40 and the artificial blood vessel 10 to inject liquid into the artificial blood vessel 10 from the injector 40, The liquid in the artificial blood vessel 10 can be selectively flowed by the operation of the user so that the fluid can flow in the artificial blood vessel 10.

Due to the injector 40 and the 3-way cock 42, the experimenter injects an appropriate amount of blood into the artificial blood vessel to form hypertension or hypotension, or injects a fluid other than blood Allow the body fluid to change.

For example, physiological saline is replaced by blood to change the body fluid in the artificial blood vessel 10, and blood or artificial blood of an animal treated with an anticoagulant (CPDA1, EDTA, oxalate, heparin, etc.) After the measurement of the cell blood volume (PCV) of the blood, it is possible to replace the blood flowing in the artificial blood vessel by diluting it with a fluid containing physiological saline or fat within a range of 10% to 80% of human blood PCV value.

After observing the veins in the physiological saline solution, the change of cholesterol in the blood of the rats can be observed after the observation of the final pulse due to changes in cholesterol and the like.

The control unit 50 is connected to the pulse generating unit 20 and controls the magnitude, speed, or interval of the pulse according to a user's input.

The control unit 10 may be configured to input pulse wave information generated by a user's input or stored in advance, and may be connected to the pulse generating unit through a normal computer interface unit, , A program for controlling the speed or the interval.

In the present invention, the pulse generation section 20 is provided with a pulse generation section 30 and a pulse removal section 30, which is a section for mimicking capillary blood vessels. Thus, an artery (pulse) section similar to a living body, The capillary and venous (non-pulsed) sections have been completed to complete the in vitro system for pulse studies.

Further, the present invention may further include an ultrasonic device for observing a vein in an artery section of the artificial blood vessel to observe a virtual radial artery blood vessel.

3 is an ultrasound image showing that a vein is observed in the artificial blood vessel 10 when the pulse generating unit 20 is operated in the present invention.

As a result of observing the artificial blood vessel 10, which is a virtual radial artery blood vessel, by using an ultrasonic apparatus in order to observe the vein vein in the in vitro vein recreation system of the present invention, And a pulse was successfully observed as shown in the lower Doppler image when the pulse generator 20 was operated.

It can be confirmed that the Mac system can be implemented using artificial blood vessels in vitro and that the present invention has been successfully accomplished.

In the in vitro pulse generation system of the present invention, when a vein is observed in the vein observation unit 12a using a pulse wave analyzer (Daeyo Medical), the vein is observed but the pump noise signal of the pulse generation unit 20 is caught The program did not get any results for the Mac.

In order to eliminate the pump noise, a method is proposed in which a ground is provided in the pulse generating unit 20 and a shield box is provided to observe a vein after noise is removed. In this case, It can be done.

According to the present invention as described above, a human's vein can be reproduced.

Example  One

Assuming that an average pulse is 72 times per minute, the pulse generator 20 can be adjusted in speed through an interface with a computer to best implement pulse of the radial artery.

After installing the artificial blood vessel 10 on the arm model of the human body using a silicone tube having an inner diameter of 3 mm and setting the speed to 72 per minute and installing the pulse removing unit 30, And confirmed by ultrasonic Doppler.

It was confirmed that pulse detection was possible when the pulse of the pulse was generated 40 times, 72 times, 80 times, 100 times per minute by using the control unit 50 of the computer.

Further, in order to confirm that the vein reconstruction system of the present invention works well when the vein is under the skin and subcutaneous anatomical structure like the radial artery, it is necessary to purchase the pig tissue including the skin, subcutaneous and muscle layer, insert the artificial blood vessel subcutaneously, After setting the pulse generator 20 to 72 times, the pulse was normally detected through Doppler and palpation.

In this case, physiological saline was replaced with blood for the change of body fluid in the artificial blood vessel 10, and the blood of the rat was mixed with CPDA1, which is an anticoagulant, at a ratio of 10% to mimic blood of a human, After measuring the blood volume (PCV), dilute the physiological saline to 10% to 80% of the human blood PCV, and use the blood as the liquid instead. Here, it is most preferable to dilute physiological saline to a blood PCV average value of 50% as a liquid instead of blood.

Through the present invention constructed as above, it was confirmed through ultrasonic Doppler that the following vein among the 28 Macs described in Oriental Medicine was observed.

(1) Veins:

- The pulse rate recorded in the protocol is 1 minute.

- Promotion, observation of ultrasonic Doppler phase.

(2) Arms:

- The pulse rate recorded in the protocol is increased to more than 108 times per 1 minute, 18 breaths, 72 times.

- Promotion, ultrasonic Doppler observation.

(3) Bloat:

- Observe the vein on the tube surface by hand as documented in the protocol, and then adjust the pressure in the occluded vascular syringe so that the vein disappears when the tube is pressed.

- Promotion, ultrasonic Doppler observation.

- Observe whether the Doppler image is observed when the ultrasonic Doppler probe is slowly pressed, and whether the Doppler image disappears when the pressure is applied.

(4) Vaporization

- Adjust the syringe pressure in the closed vein so that the pulse is felt when the tube is pressed with the hand untreated on the tube surface.

Compare the results of stimulation, ultrasound, and pulse.

Example  2

In this embodiment of the present invention, it was confirmed through the ultrasonic Doppler that the following vein was observed among the twenty-eight veins described in Oriental medicine through palpation of the oriental medicine, ultrasound Doppler, and pulse.

In this case, it was verified that the vein was appropriately reflected in the silicon tube, verified that the vein was reproduced in the silicon tube according to the designed contents, and the vein content of the oriental medicine was compared with the vein reproduced in the silicon tube.

(1) rhythm (string)

- Shooting by changing the diameter of the silicon tube

- Silicon tubes with various internal diameters such as 2.4, 3.1, and 4.8 mm

- Verification of the contents of the circulation of the oriental doctor and the vein reproduced in the silicone tube with the ultrasonic Doppler and the pulse.

(2) Blood vessels:

- Check if blood vessels are enlarged according to blood pressure.

At 120, 140, 160, and 180 mmHg pressure, the change of the pulse is accelerated, compared with the ultrasound and pulse.

- Prediction: Ultrasound imaging will take the form of blood vessels will be taken when pressure is measured at the pressure of about a bang, and pressurization will not shoot the mac.

- Verification of the contents of the circulation of the oriental doctor and the vein reproduced in the silicone tube with the ultrasonic Doppler and the pulse.

(3) Weapon:

- I want to make a Mac that is weaker than Mac, and thinner and less powerful than Mac.

- 120 mmHg to 100, 80, 60 mmHg while lowering the appearance of oriental medical herb is observed to facilitate.

- Verification of the contents of the circulation of the oriental doctor and the vein reproduced in the silicone tube with the ultrasonic Doppler and the pulse.

Example  3

Hyperlipidemic conditions were established in the silicone tube through the blood of the model and then compared with those of hypertension. Hyperlipidemia was compared with normal blood vessels (or differences in density) between blood vessels in blood vessels, and the contents of blood circulation in the oriental medicine and silicon vascular tissues were compared with those of ultrasonic Doppler and pulse.

It was confirmed that the change of the lipid component (Glyceryl Trioleate) (Sigma Aldrich) in the artificial blood vessel constituting the closed circulatory system of the present invention was increased to 72, 120 mmHg and 3 mm inner diameter by 5, 10, 15 and 20% .

Example  4

By reducing the model blood in artificial blood vessels constituting the closed circulatory system of the present invention, the blood vessels according to the bleeding symptom were prepared in the silicone tube, and then the vascular expression corresponding to the bleeding was compared.

The blood vessels in the artificial blood vessels were 3%, 6%, 9%, 12% and 15%, respectively. , And 20%, respectively, while comparing the phases of the Chinese medicine doctor, ultrasound, and pulse.

The present invention can improve the pulse rate of learners and oriental medicine practitioners by reproducing various kinds of muscles of the human body mechanically, thereby objectifying the diagnostic evaluation of the oriental medicine doctor and raising the accuracy of the vein.

In addition, by using ultrasonic Doppler images in the Mac, it is an innovative idea different from the existing concept in that it attempts to standardize the pulse by standardizing the Mac by using the results of the monopolar pulse rate, the pulse rate pulse, and the ultrasonic Doppler result.

It is to be understood that the invention is not limited to the disclosed embodiment, but is capable of many modifications and variations within the scope of the appended claims. It is self-evident.

10: artificial blood vessel 12: arterial section
12a: Mac observer 14: Vein section
20: Pulse generator 30: Pulse generator
40: blood pressure / body fluid adjuster 50:

Claims (8)

An artificial blood vessel forming a closed circulation system in which the fluid can circulate;
A pulse generator installed at one side of the artificial blood vessel to generate a pulse in the artificial blood vessel so as to form a certain section of the artificial blood vessel as an artery section in which pulses are present;
A pulse remover installed at an arbitrary position of the artificial blood vessel such that a certain section of the artificial blood vessel is formed as a vein section without a pulse except for the arterial section;
A vein observing part formed in an arterial section of the artificial blood vessel so as to observe various pulse waves of a human body reproduced by the pulse generating part;
The blood pressure or the body fluid control is adjusted so as to adjust the blood pressure of the fluid circulating in the artificial blood vessel by injecting fluid into the arterial section or to exchange the fluid circulating in the artificial blood vessel and observe the change of the vein according to the body fluid change in the blood. A blood pressure / body fluid adjuster for performing blood pressure adjustment; And
A control unit connected to the pulse generating unit through a computer interface unit and including a program for controlling the size, speed or interval of the pulse by a user's input;
Wherein the in vitro macro-representation system comprises:
The method according to claim 1,
Wherein a part of the artificial blood vessel is wound inside the pulse generating unit to form a closed circulatory system and a pulse is generated by pressing the artificial blood vessel at a constant cycle in the pulse generating unit.
The method of claim 2,
Since the pulse is generated in the process of drawing the fluid into the pulse generator, the artificial blood vessel in the portion where the fluid is drawn out from the pulse generator forms the artery section,
Wherein the artificial blood vessel in the portion into which the fluid is introduced into the pulse generating unit forms a vein section.
The method according to claim 1,
Wherein the artificial blood vessel is an artificial blood vessel composed of a silicon tube having a predetermined diameter, biological or non-biological derived material.
The method according to claim 1,
Wherein the pulse eliminator is formed by providing a capillary between the arterial section and the vein section so as to distinguish the artery section in which the pulse is present and the vein section that is not pulsed in the artificial blood vessel.
The method according to claim 1,
Wherein the blood pressure / body fluid regulator comprises an injector for injecting fluid into the arterial section,
And a 3-way cock provided between the injector and the artificial blood vessel for selectively injecting a liquid into the artificial blood vessel to exchange liquid in the artificial blood vessel or increase or decrease the blood pressure. In-beat Mac representation system.
The method according to claim 1,
Wherein the vein observing unit further includes artificial skin that surrounds the artificial blood vessel and transmits pulses generated from the artificial blood vessel for pulse training.
The method according to claim 1,
Further comprising an ultrasound device and a pulse generator for observing a vein in an arterial section of the artificial blood vessel and observing a virtual radial artery blood vessel.

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