KR20180109100A - Sleep Apnea Monitoring System interlocked with guardian cell phone - Google Patents

Abstract

The present invention relates to a sleep apnea status monitoring system interlocked with a protector′s smartphone, which transmits a respiration signal from a continuous positive pressure maintaining device to a apnea detection module wherein the apnea detection module comprises a user′s smartphone, determines whether a sleep apnea or a low respiration is detected from the received respiration signal, determines the risk by using the frequency of occurrence of sleep apnea, and outputs an emergency notification signal to the protector′s smartphone in a dangerous state. According to the present invention, the sleep apnea status monitoring system comprises: a respiration detection unit equipped or mounted on the continuous positive pressure maintaining device, and detecting a nasal airflow of a subject as a respiration signal; and a subject terminal including an arithmetic processing unit for wirelessly receiving the respiration signal detected by the respiration detection unit to detect an apnea interval, a low respiratory interval, and the number of occurrences of the apnea interval from the received respiration signal. The arithmetic processing unit of the subject terminal performs a preprocessing for removing high frequency noise and baseline variation from the respiration signal received from the respiration detection unit; detects, as a peak point, a respiration signal having a maximum value in a respiration signal having a predetermined maximum threshold value or more among the preprocessed respiration signals; detects, as a trough point, a respiration signal having a minimum value in a respiration signal having a predetermined minimum threshold value or less; and then calculates, by the amplitude of a respiration cycle, the difference between the value of the peak point and the value of the trough point at successive peak points and trough points.

Description

[0001] The present invention relates to a sleep apnea monitoring system interlocked with a guardian smartphone,

The apnea detection module transmits the breath signal to the apnea detection module. The apnea detection module is configured by the user's smartphone. The apnea detection module determines sleep apnea and hypoventilation from the received respiration signal, To a sleep apnea monitoring system in which a sleeping apnea occurrence frequency is used to determine a danger and a warning signal is output to a guardian's smartphone when the person is in a dangerous state.

 A positive pressure maintaining device (positive pressure device) is a device that applies positive pressure to the air to narrow the narrowed or occluded airway by partial occlusion of the upper airway during sleeping time. It is mainly used for patients with severe sleep apnea.

 Recently, Meghealthcare developed Mysleep application from domestic M3 development process. That is, sleep data is managed using a smartphone. In case of Mysleep, connect the USB interface that inserted the SD card to the mobile phone and read the SD card by reading the data. Then, the data is automatically loaded in the application. In the application, the pressure setting, usage time, sleep index, pressure, apnea ) Index, hypopnea index, and snoring.

 It is very difficult for the user who is in actual apnea status to recognize the dangerous situation and cope with it.

 Therefore, there is a need for a sleep apnea condition monitoring system that judges the degree of danger and informs the caregiver. Particularly, a sleep apnea monitoring system that accurately and accurately judges a certain frequency, a certain duration, and the like of a dangerous state, an emergency situation, and the like in an instantaneous occurrence of a sleep apnea signal is desired.

Prior art is the apnea monitoring system and method of Korean Patent No. 10-2015-0056301. The present invention relates to a respiration measurement device that transmits a respiration signal of a patient recovering from an anesthesia state after surgery or a procedure as a data packet, and a respiration monitoring application that analyzes a data packet provided by the respiration measurement device, And a smart phone for detecting a change, outputting it in a predetermined format, and providing the medical team with monitoring information.

Korean Patent Laid-Open No. 10-2015- 0056301 discloses a method for analyzing an amplitude of a peak in a respiration signal of a patient to determine apnea and analyzing the amplitude of the peak by period or the amplitude of the peak in the respiration signal of the patient If the respiratory rate per minute or the apnea period is out of the set reference value, it is determined that the patient is in emergency. However, if apnea is judged by considering only the amplitude magnitude of the peak per cycle without considering the maximum value (peak amplitude) and minimum value per cycle, there is a problem in accuracy.

In patients recovering under anesthesia after surgery or surgery, the amplitude of the peaks per cycle or the peak amplitude per cycle is analyzed to determine that the respiratory rate per minute or the apnea period is out of the range of the set reference value. It may be necessary, but if you apply this method to the public, it is often misdiagnosed in spite of its steady state.

Accordingly, in the present invention, the amplitude of a breathing cycle is obtained by obtaining a maximum value and a minimum value using a threshold, and the amplitude of the breathing cycle is divided into an apnea interval and a low breathing interval by a low breathing threshold and an apnea threshold, And apnea threshold are obtained by using the average of normal breathing and the average of normal breathing is calculated as the average of the recent 6 respirations.

SUMMARY OF THE INVENTION The object of the present invention is to transmit a respiratory signal from a sustained positive pressure retainer to an apnea detection module, wherein the apnea detection module is made up of a user's smartphone, and the apnea detection module detects sleep apnea, A sleep apnea status monitoring system in which the sleep apnea occurrence frequency is used to judge whether or not a danger is present and to output an emergency notification signal to the guardian's smartphone when the patient is in a dangerous state, will be.

Another problem to be solved by the present invention is to provide a sleep apnea monitoring system configured to determine a degree of danger by using parameters such as an amplitude of a respiratory cycle, a number of times of apnea and low respiration, and duration of apnea .

Another problem to be solved by the present invention is to obtain the amplitude of a breathing cycle by obtaining a maximum value and a minimum value using a threshold value and divide the amplitude of the breathing cycle into apnea interval and low breath interval by low breath threshold and apnea threshold , The low respiratory threshold and the apnea threshold are obtained using an average of normal breaths and the average of normal breaths is calculated as an average of the recent six breaths.

In order to solve the above problems, the sleep apnea monitoring system of the present invention is equipped with or attached to a persistent positive pressure retainer, and includes a respiratory detection unit that detects the nasal airflow of the subject's nasal cavity as a respiration signal; And an arithmetic processing unit that wirelessly receives the respiration signal detected from the respiration detection unit and detects an apnea interval, a low respiration interval, and an apnea interval occurrence count in the received respiration signal.

The subject terminal is any one of a smart phone, a node book, a mobile phone, and a smart pad.

The arithmetic processing unit of the subject terminal performs a preprocessing for removing high frequency noise and baseline variation from the respiration signal received from the respiration detection unit and outputs a respiration signal having the maximum value in a respiration signal of a predetermined maximum threshold value or more among the preprocessed respiration signals, and a respiration signal having a minimum value in a respiration signal below a predetermined minimum threshold is detected as a trough point and the value of the peak point at the subsequent peak point and trough point is detected. The difference between the values of the rough points is obtained by the amplitude of the breathing cycle.

The subject terminal informs the pre-registered guardian terminal of the emergency situation when the number of times of occurrence of the apnea interval is equal to or greater than the preset threshold value of the apnea number of breathers or the duration of the apnea interval exceeds the preset apnea threshold value.

When the amplitude of the respiratory cycle is lower than the low breath threshold, it is determined that the breath is low and the low breath threshold (H _TH ) is H _TH = AVG _NORMAL X 0.6 (where AVG _NORMAL is the subject's normal breathing average), and if the amplitude of the respiratory cycle is less than the apnea threshold, it is determined to be apnea and the apnea threshold (A _TH ) is A _TH = AVG _NORMAL X 0.1 (where AVG _NORMAL is the subject's normal breathing average).

The arithmetic processing unit of the subject terminal uses a 40 point Moving Average Filter to remove high frequency noise from the respiration signal and uses a 30 point median filter to remove baseline variation in the respiration signal. .

A respiratory air current detecting sensor for detecting air current in the nasal cavity in the respiration detecting portion is mounted on the nasal air providing means of the persistent positive pressure retainer mounted on the nose.

The present invention also provides an arithmetic processing unit for receiving the nasal air current of the subject's nasal cavity from the respiration detecting unit mounted on the sustained positive pressure maintaining device and for detecting the number of times of the apnea interval, the low respiratory interval, and the apnea interval in the received respiration signal Wherein the arithmetic processing unit of the subject terminal performs a pre-processing for removing high-frequency noise and baseline variation from the respiration signal received from the respiration detection unit, and performs a preprocessing of the preprocessed breathing signal A respiration signal having a maximum value is detected as a peak point and a respiration signal having a minimum value in a respiration signal below a predetermined minimum threshold is detected as a trough point in a respiration signal having a predetermined maximum threshold value or more And the difference between the peak point value and the trough point value at successive peak points and trough points is set to be And is obtained by the amplitude.

In addition, the present invention is characterized in that, as a respiration signal, a nasal airflow of a subject is read from a respiration detection unit mounted on a sustained positive pressure retainer, the received respiration signal is temporarily stored in a memory unit, the temporarily stored respiration signal is read, An arithmetic processing unit for setting the low respiratory flag when the amplitude of the respiratory cycle is smaller than the low respiratory threshold value and setting the apnea flag when the amplitude of the respiratory cycle is smaller than the apnea threshold value The method comprising the steps of: receiving a respiration signal from a memory unit of an arithmetic processing unit; The arithmetic processing unit checks whether the respiration signal received in the respiration signal receiving step is a trough point, which is a respiration signal having a minimum value among respiration signals below a minimum threshold value. Trough point check step; Determining whether the amplitude (Amp [k]) of the current breathing cycle, which is the breathing cycle including the current breathing signal, is less than the low breathing threshold, if the breathing signal is a trough point; 1 low breath threshold; If the amplitude (Amp [k]) of the current breathing cycle is smaller than the low breathing threshold in the comparison with the first low breathing threshold, it is determined whether the amplitude (Amp [k]) of the current breathing cycle is smaller than the apnea threshold , A step of comparing with a first apnea threshold; If the amplitude (Amp [k]) of the current breathing cycle is not less than the apnea threshold in the comparison with the first apnea threshold, the amplitude (Amp [k-1] If it is not smaller than the threshold, it is reset to zero and the apnea counter is cleared to zero. If the apnea flag is set to be 1, it is checked if the apnea flag is set to 1, A second apnea threshold value for storing the apnea threshold value TMP _Apnea and the apnea threshold value with the interval data Apnea [i]; If the amplitude (Amp [k]) of the current breathing cycle is not smaller than the apnea threshold in the comparison with the first apnea threshold, it is checked whether the low breathing flag has already been reset to 0, Determining whether to reset the first low respiratory flag to set the low respiration flag to 1 and store the current respiration signal, that is, the time point of the current respiration signal, at the starting point of low respiration (TMP _Hypop ) .

In the driving method of the sleep apnea monitoring system of the present invention, in the step of checking the trough point, if the respiration signal is not a trough point, it is checked whether the low respiration flag has already been set to 1, If the breathing signal is not a trough point, if the breathing signal is not a trough point, a step of ascertaining whether or not the breathing signal is set to 1 And if it is set to 1, increasing the apnea counter and returning to the respiration signal receiving step, a step of checking whether or not the first apnea flag is set.

The driving method of the sleep apnea monitoring system of the present invention is based on the comparing step from the first apnea threshold value, if the amplitude (Amp [k]) is less than the apnea threshold of the current breath cycle, already, hypopnea flag (State _H Confirming whether the second low respiration flag is set to 1, increasing the low respiration counter if it is set to 1, and returning to the respiration signal receiving step; If the amplitude (Amp [k]) of the current breathing cycle is smaller than the apnea threshold in the comparison with the first apnea threshold, it is checked whether the apnea flag has already been reset to zero, and if not, Determining whether or not to reset the first apnea flag if the apnea counter has been reset and has been reset to 0, sets the apnea flag to 1, stores the time of the current breath signal at the apnea start point, ; ≪ / RTI >

The driving method of the sleep apnea monitoring system of the present invention is characterized in that if the amplitude of the current breathing cycle (Amp [k]) in the comparison with the first low breathing threshold is not smaller than the low breathing threshold, Comparing with the second low respiratory threshold to determine whether the amplitude (Amp [k-1]) of the respiratory cycle is less than the low respiratory threshold; If the amplitude (Amp [k-1]) of the breathing cycle before the current breathing cycle is smaller than the low breathing threshold in the comparison with the second low breathing threshold, the breathing cycle of the previous breathing cycle following the current breathing cycle A third low breath threshold to determine if the amplitude Amp [k-2] is less than the low breath threshold; If the amplitude (Amp [k-2]) of the respiratory cycle after the current breathing cycle is smaller than the low breathing threshold in the step of comparing with the third low breathing threshold, the low breathing flag (State _H ) 1, if it is set to 1, increasing the low respiration counter and returning to the respiration signal receiving step; If the amplitude (Amp [k-2]) of the respiratory cycle before the current breathing cycle is smaller than the low breathing threshold in the step of comparing with the third low breathing threshold, if the breathing flag has already been set to 1 Determining whether or not the second apnea flag is set to increase the apnea counters and return to the respiration signal receiving step if it is set to 1;

The driving method of the sleep apnea monitoring system of the present invention is characterized in that, in the comparison with the third low respiratory threshold value, the amplitude (Amp [k-2]) of the respiratory cycle following the current respiration cycle is shorter than the low respiratory threshold If it is not small, it is determined whether the value of the low respiration counter is larger than the low respiration duration threshold value. If it is larger than the low respiration duration threshold, the low respiration start point (TMP _Hypop ) is set to the current ( _i- And a low breathing duration comparing step for storing the low breathing counter value and returning to the breathing signal receiving step; If the amplitude (Amp [k-2]) of the respiratory cycle following the current breathing cycle is not less than the low breathing threshold in the step of comparing with the third low breathing threshold, the value of the apnea counter is set to the apnea duration threshold (TMP _Apnea ) and the apnea counter value (Cnt _Apnea ) with the current (i-th) apnea interval data Apnea [i] And returning to the apnea duration comparison step.

The driving method of the sleep apnea monitoring system of the present invention is characterized in that, in the comparison with the second low respiratory threshold value, the amplitude (Amp [k-1]) of the respiratory cycle before the current respiration cycle is smaller than the low respiratory threshold If it is set to 1, it is determined whether the value of the low breathing counter is larger than the low breathing duration threshold value. If it is larger than the low breathing duration threshold value, A fourth low respiration flag set confirmation step of storing a low respiration start point (TMP _Hypop ) and a low respiration counter value (Cnt _Hypop ) with low respiratory interval data (Hypop [i]) and returning to a respiration signal reception step ; If the amplitude (Amp [k-1]) of the breathing cycle before the current breathing cycle is not less than the low breathing threshold in the step of comparison with the second low breathing threshold, whether the breathing flag has already been set to 1 If it is set to 1, it is determined whether the value of the apnea counter is larger than the apnea duration threshold value. If the value is greater than the apnea threshold value, the apnea threshold value TMP (i) _Apnea ) and an apnea counter value (Cnt _Apnea ), and determining whether or not the third apnea flag is set.

A computer readable recording medium storing a computer program source for a driving method of a sleep apnea monitoring system of the present invention.

In the sleep apnea monitoring system of the present invention, the respiratory signal is transmitted to the apnea detection module from the persistent pressure maintainer, the apnea detection module is made up of the user's smartphone, The sleep apnea occurrence frequency is used to judge whether or not there is a risk of sleep apnea, and if the patient is in a dangerous state, the emergency call notification signal is output to the guardian's smartphone.

The present invention is configured to determine the degree of risk using parameters such as the amplitude of the respiratory cycle, the number of occurrences of apnea and hypopnea, and duration of apnea.

In the present invention, the amplitude of a breathing cycle is obtained by obtaining a maximum value and a minimum value using a threshold value, and the amplitude of the breathing cycle is divided into an apnea interval and a low breathing interval by a low breathing threshold and an apnea threshold, The threshold is obtained by using the mean of normal breathing, and the average of normal breathing is calculated to be the average of the recent 6 respirations, and has higher accuracy.

1 is a schematic diagram illustrating a schematic configuration of a sleep apnea monitoring system of the present invention.
FIG. 2 is a block diagram for explaining the configuration of the sustained positive pressure maintaining device and the subject terminal in the sleep apnea monitoring system of FIG. 1;
FIG. 3 is an explanatory diagram schematically explaining a driving method of the operation processing unit of the subject terminal of FIG. 2;
FIG. 4 is a use state diagram of the sleep apnea monitoring system of FIG. 2. FIG.
5 is an example of a result output from the digital preprocessing step (S20) in the operation processing unit of the subject terminal of FIG.
6 is an example of the result output from the feature extraction step in the operation processing unit of the subject terminal of FIG.
7A is a flowchart for explaining a part of the post-processing step in the operation processing unit of the subject terminal of FIG.
FIG. 7B is a flow chart illustrating another portion of the post-processing step that is subsequently processed in the post-processing step of FIG. 7A.
8 is an example of a result of detecting an apnea and a low breathing event in the arithmetic processing unit of the subject terminal of Fig.
Fig. 9 is an example of a screen showing a state under measurement in the subject terminal of Fig. 2;

Hereinafter, a sleep apnea monitoring system linked to a guardian smartphone of the present invention will be described with reference to the accompanying drawings.

1 is a schematic diagram illustrating a schematic configuration of a sleep apnea monitoring system of the present invention.

The persistent positive pressure retainer 100 is also referred to as a positive pressure maintenance device or a positive pressure device, or a positive pressure respirator, or a CPAP (Continuous Positive Airway Pressure) device, and continuously inflows air into the airway. The sustained positive pressure retainer 100 of the present invention is configured to detect a respiratory signal and wirelessly transmit the signal to the subject terminal 200. The respiratory signal of the present invention is a signal obtained by measuring respiratory air flow or pressure (air pressure) through the nasal cavity.

Generally, the sleep breathing disorder is caused by temporary clogging of the airway, and the persistent positive pressure maintainer 100 is a means for constantly inflating air into the airway so that such airway obstruction does not occur. The positive pressure maintaining device 100 prevents the space of the upper passageway from narrowing by filling the air in the mouth.

The sustain positive pressure maintaining device 100 includes a nasal air providing means 101 and a sustain positive pressure maintaining controller 107. [ The sustain positive pressure maintaining controller 107 is a means for continuously controlling air (airflow) to be output. The nasal air supplying means 101 is means for inserting the air sent from the sustain positive pressure maintaining controller 107 into the nose (nasal cavity), wherein a mask connected to the air tube or the air tube is mounted on the nose, A hair bend for mounting a mask connected to the air tube to the nose, and the like.

The subject terminal 200 performs a preprocessing process for removing noise or the like from the received respiration signal and detects the maximum value as a peak in a respiration signal having a maximum threshold value or more in a respiration cycle, The respiratory signal is detected as trough and the amplitude of one respiratory cycle is calculated as the difference between the peak point and the trough point and the apnea interval and the low respiration interval are determined by the apnea threshold and the low respiration threshold Display them or store them, and in some cases, transmit them to the guardian terminal 300 or a personal computer (not shown), and display or store them. In addition, the examinee terminal 200 determines the risk based on the apnea interval, the low respiratory interval, the number of apneas, the number of low respirations, and transmits the risk to the guardian terminal 300.

The subject terminal 200 can confirm whether or not the subject has a sleeping respiratory disorder in real time and can transmit the subject person's terminal 200 or the guardian's terminal 300 or personal computer .

Also, the subject terminal 200 generates a control signal for the sustained positive pressure retainer 100 based on the set value set by the subject or the like, and the sustained positive pressure retainer 100 receives the control signal, The sustain positive pressure maintaining device 100 can be controlled.

The guardian terminal 300 can store or display information transmitted from the subject terminal 200 to a terminal designated through authentication or the like in the subject terminal 200. When the subject is in a dangerous state, And so on.

In some cases, a main server (not shown) may be further provided. The main server (not shown) provides a predetermined application program and can store and manage data received from the subject terminal 200.

The subject terminal 200 and the guardian terminal 300 may be personal terminal devices, such as a smart phone, a mobile phone, a smart pad, a notebook computer, and a personal computer. The examinee terminal 200 and the guardian terminal 300 are terminals equipped with a predetermined application program (application).

FIG. 2 is a block diagram for explaining the configurations of the sustained positive pressure retainer 100 and the subject terminal 200 in the sleep apnea monitoring system of FIG. 1. FIG. FIG. 4 is a use state diagram of the sleep apnea monitoring system of FIG. 2; FIG.

The sustained positive pressure retainer 100 includes a respiration detection unit 110 and a transceiver unit 150.

The respiration detection unit 110 measures the respiratory air flow or pressure in the nasal cavity and outputs the result as an electrical signal. The respiratory air flow signal or pressure of the nasal cavity thus measured is used as a breathing signal. The preferred respiratory signal is the nasal flow (nasal flow) of the nasal cavity. The respiration detection unit 110 may include a respiratory air current detection sensor (not shown) and an analog preprocessor (not shown).

The respiratory air current detection sensor (not shown) is mounted on the nasal air supply means 101 or the like of the sustained positive pressure retainer 100 and detects an air flow in the nasal cavity, that is, a respiratory air current, as a respiration signal, A pressure sensor can be used as the breathing air flow detection sensor.

An analog preprocessing unit (not shown) performs a preprocess such as removing noise from a breathing signal received from a breathing air flow sensor (not shown) and removing noise.

The transceiver unit 150 is mounted on the sustain positive pressure controller 107 or the like of the sustained positive pressure retainer 100 and converts the respiration signal pre-processed in the analog preprocessor (not shown) into a signal for wireless transmission, 200).

The arithmetic processing unit 250 of the examinee terminal 200 receives the respiratory signal through the transceiver 210 and performs an arithmetic processing process as shown in FIG. 3 from the received respiration signal to generate an apnea interval, a low respiration interval, The number of times of low breathing, and the like are detected and displayed on the display unit 260 or stored in the memory unit 270. The subject or the like can set a set value necessary for driving the sustain positive pressure retainer 100 and the like through the key input unit 280 and the operation processing unit 250 sets the control signal of the sustain positive pressure retainer 100 And the control signal is transmitted to the sustain positive pressure retainer 100 through the transmission / reception unit 210. [ The sustain positive pressure retainer 100 receives the control signal through the transceiver 150 and controls the sustain positive pressure retainer 100 according to the control signal.

3, the operation processing unit 250 of the examinee's terminal 200 includes a respiration signal receiving step (S10), a digital preprocessing step (S20), a feature extraction step (Featurw Extraction) (S30), and a post-processing step (Posr Processing) (S50).

The respiration signal receiving step (S10) receives the respiration signal (that is, the respiratory signal, the nasal airflow signal) through the transceiver 210 by the operation processing unit 250.

In the digital preprocessing step S20, the arithmetic processing unit 250 removes high frequency noise from the respiration signal received in the respiration signal receiving step S10 and eliminates baseline fluctuation. The digital preprocessing step S20 includes a moving average filtering step and an intermediate value filtering step.

In the moving average filtering step, the arithmetic processing unit 250 performs filtering using a moving average filter to remove high frequency noise from a breathing signal (nasal airflow signal). Here, as the moving average filter, a 40-point moving average filter can be used. The 40 point moving average filter calculates the mean value of the previous 40 respiration signals (40 points) including the current point from the past breath signal to the current breath signal (current point) as the current point value . That is, the moving average filter is performed by shifting the 40-point window.

The median filtering process removes baseline variation using a median filter (median filter) in the operation processing unit 250. Here, the median filter may use a 30-point median filter. The 30 point median filter outputs the median value of the previous 30 respiration signals (30 points) including the current point from the past breath signal to the current breath point (current point) as the current point value do. That is, the median filtering is performed by shifting the 30-point window.

The feature extraction step S30 includes a step of detecting a peak point and a trough point, a step of calculating an amplitude of a respiration cycle, and an Aplitude Calculation step.

Peak point and trough point detection step (Peak / Trough Point Detection) detects the respiration signal having the maximum value in the respiration signal exceeding the maximum threshold value as the peak point (maximum point) in the arithmetic processing unit 250 , The respiration signal having the minimum value in the respiration signal below the minimum threshold is detected as a trough point (minimum point). At this time, the value of the peak point (the amplitude of the peak point) is referred to as a peak value, and the value of the trough point (amplitude of the trough point) is referred to as a trough value.

Here, the maximum threshold value and the minimum threshold value may be a value set at the time of factory shipment, and in some cases, the user (the subject, medical professional, etc.) may be a value set through the subject terminal 200 at the beginning of use, (For example, a predetermined percentage value of the average of the user's respiratory flow, etc.) by detecting the respiratory flow of the subject at the beginning of use and automatically set by the detected respiratory flow.

The amplitude calculation step (Applitude Calculation) of the respiratory cycle is performed in the calculation processing unit 250 so that the peak points at the successive peak points and the trough points at the peak points and the trough points obtained at the detection step of the peak points and trough points, Find the difference in the trough value and use it as the amplitude of the current breathing cycle. Here, the successive peak points and trough points may be the case where the peak point is first, followed by the trough point, or the trough point is first and then the peak point is next. In the present invention, the respiratory cycle refers to a time interval between successive peak points and trough points.

In the post-processing step (S50), the apnea interval and the low respiration interval are obtained using the apnea threshold and the low respiration threshold in the respiration signal through the feature extraction step (S30). Details will be described later.

4, the subject mounts the nasal air supplying means 101 of the sustained positive pressure maintaining device (positive pressure sustaining device) 100, interlocks the subject terminal 200 and the sustained positive pressure maintaining device 100, The subject terminal 200 confirms whether or not the subject has a sleep-disordered breathing disorder in real time, informs the subject via an alarm or the like in the case of a dangerous state, and informs the guardian terminal 300 of the dangerous state .

5 is an example of the result output from the digital preprocessing step S20 in the operation processing unit 250 of the subject terminal 200 of FIG.

5A is an example of the respiration signal received in the signal reception step S10. That is, this is an example of a respiration signal (nasal airflow signal) before passing through the digital preprocessing step S20.

5 (b) is a respiration signal receiving step (S10) through a digital preprocessing step S20, in FIG. 5 (a). FIG. 5B shows that noise such as high-frequency noise is removed as compared with FIG. 5A.

6 is an example of the result output from the feature extraction step S30 in the operation processing unit 250 of the subject terminal 200 in FIG.

6A is an example of a result of detecting peak points (blue circles) and trough points (red circles) in the respiration signal (nasal airflow signal) in the detection step of the peak point and trough point .

6B shows a case in which the respiration signal that has undergone the detection step of the peak point and the trough point in FIG. 6A detects the amplitude (pink line) of the respiratory cycle through the amplitude calculation step of the respiratory cycle Output.

In the present invention, the arithmetic processing unit temporarily stores the respiration signal (non-intense airflow signal) received from the positive pressure sustainer in a predetermined size in the memory unit 270, and performs arithmetic processing using the temporarily stored respiration signal data. The memory for temporarily storing the respiration signal may be a buffer or a ring buffer.

7A is a flowchart for explaining a part of the post-processing step (S50) in the calculation processing unit 250 of the subject terminal 200 in FIG. 2, FIG. 7B is a flowchart for explaining a part of the post- And then a further part of the post-treatment step being treated.

In the respiration signal reception step, the operation processing unit 250 reads the respiration signal through the feature extraction step S30 from the memory unit 270 (i.e., the ring buffer) (S105).

Here, X _f (n) is the nth respiration signal among the respiration signals sampled at the sampling frequency f.

It is checked whether or not the respiration signal received in the respiration signal reception step S105 (that is, the nth respiration signal which is the current respiration signal) is a trough point (minimum point) If the respiration signal is not a trough point (minimum point), it is checked whether the first low respiratory flag is set (S120) and whether or not the first apnea flag is set (S130) Point), the process goes to the comparison step (S160) with the first low respiratory threshold value.

If the current breath signal is not a trough point (minimum point) in the trough presence check step (S110), it is determined whether the low breath state flag (State _H ) Respiration counter Cnt _Hypop is set to 1 if it is set to 1, and if it is not set to 1, (Increment) (Cnt _Hypop ++) (S140), and returns to the respiration signal reception step (S105). Here, the low respiration counter (Cnt _Hypop ) is a counter for detecting a time interval in which low breathing is continued.

If the current breath signal is not a trough point (minimum point) in the trough presence check step (S110), it is determined whether or not the first apnea flag flag is set to the apnea state flag (State _A ) It is determined whether or not the apnea counter (Cnt _Apnea ) is set to 1 (S130). If it is not set to 1, it returns to the breathing signal receiving step (S105) (Cnt _Apnea ++) (S150), and returns to the respiration signal receiving step (S105). Here, the apnea counter (Cnt _Apnea ) is a counter for detecting the time interval in which the apnea persists.

That is, if the current breath signal is not the trough point (minimum point), the trough point check step, the first low respiration flag set check step, and the first apnea flag set check step (i.e., S110 to S150) If the breathing cycle is still in progress and the breathing interval is still in progress, the low breathing counter is incremented to count the low breathing duration. If the breathing interval is already in progress, the apnea counter is incremented to count the breathing duration , And goes to the breathing signal receiving step to receive the next breathing signal.

If the current breathing signal is a trough point (minimum point) in the trough point check step (S110), it is determined that one breathing cycle is over and that the current breathing cycle amplitude (Amp [k]) to determine if less than the hypopnea threshold (H _TH) and (S160), not less, the second goes to the comparing step (S310) of the hypopnea threshold value is less, the first apnea threshold and (S170).

Here, Amp [k] refers to the amplitude of the kth (current) breathing cycle.

If the amplitude (Amp [k]) of the current breathing cycle is smaller than the low breathing threshold (H _TH ) in the comparison step S160 with the first low breathing threshold value, It is determined whether the amplitude Amp [k] of the period is smaller than the apnea threshold value A _TH at step S170. If the amplitude is not smaller than the second apnea threshold value At step S230 and the first low respiratory flag reset step S280). If it is determined that the second low respiration flag has been set, the flow goes to step S180 to check whether the second low respiration flag has been set and whether to reset the first apnea flag (step S190).

Claim If two hypopnea flag whether confirmation set of steps is less than the first amplitude (Amp [k]) the apnea threshold (A _TH) in the comparing step (S170) of the apnea threshold, the current breath cycle, already, that check that is set in the breathing flag (State _H) 1 and (S180), if not, it is not set to 1, returns to the breathing signal receiving step (S105), is set to 1 increases the hypopnea counter (Cnt _Hypop) (Cnt _Hypop ++) (S200), and returns to the respiration signal reception step (S105).

In the first apnea flag is reset if confirmation step, the comparing step of the first apnea threshold value (S170), is less than the amplitude (Amp [k]) the apnea threshold (A _TH) of the current breath cycle, already, the apnea flag (Cnt _Apnea ++) (step S220). If the state _A is not reset to 0, that is, if it is set to 1, the apnea counter Cnt _Apnea is increased (Cnt _Apnea ++) , And if it is reset to 0, the apnea flag is set to 1, and the current breathing signal, that is, the current breathing signal, is set as the apnea start point TMP _Apnea (that is, the start point of the temporary apnea, (N).

If the amplitude of the current breathing cycle Amp [k] is not less than the apneic threshold value A _{TH in} the comparison step S170 with the first apnea threshold, the current respiration cycle is compared with the second apnea threshold, It is determined whether the amplitude (Amp [k-1]) of the breathing cycle before the breathing cycle is less than the apnea threshold value A _TH at step S230. If not, the apnea flag state _A is reset to 0 and the apnea counter Cnt _Apnea ) for, if cleared, and (S270), start to zero, the apnea flag (State _a), is to ensure that is set to 1 (S250), if it is not set to 1, returns to the breathing signal receiving step (S105), 1 (TMP _Apnea ) and the apnea counter value (Cnt _Apnea ) with the i-th apnea interval data (Apnea [i]). That is, the apnea start point (TMP _Apnea ) and the apnea counter value (Cnt _Apnea ) are stored in the apnea interval data Apnea [i].

Here, in Apnea [i] = (TMP _Apnea Cnt _Apnea ), i indicates the number of times of apnea interval occurrence, i is the index of apnea. On the other hand, the value of the apnea counter (Cnt _Apnea ) is to count the number of samples in the apnea interval to know the length of one apnea interval.

If the amplitude (Amp [k]) of the current breathing cycle is not smaller than the apneic threshold value (A _TH ) in the comparison step (S170) with the first apnea threshold value, the first low respiration flag reset step (S280) It is checked whether the low breath flag (State _H ) has already been reset to zero (S280). If it is not reset to 0, the process returns to the breath signal reception step (S105) 1 and stores the current breathing signal, that is, the time point (n) of the current breathing signal, with the low breathing start point (TMP _Hypop ) (that is, the candidate of the temporary low breathing start point or the low breathing start point candidate) (S290).

If the amplitude (Amp [k]) of the current breathing cycle is not less than the low breath threshold (H _TH ) in the comparison step (S160) with the first low breath threshold, It is determined whether the amplitude (Amp [k-1]) of the breathing cycle before the breathing cycle is smaller than the low breathing threshold value H _TH (S310) And the third apnea flag set set (S450). If the third apnea threshold is smaller than the third apnea threshold, the process goes to step S320.

The comparison of the third low respiratory threshold value with the second low respiratory threshold value is made by comparing the amplitude (Amp [k-1]) of the respiratory cycle before the current respiration cycle to the low respiration threshold value H _TH ), it is determined whether the amplitude (Amp [k-2]) of the respiratory cycle following the current breathing cycle is smaller than the low breathing threshold value ( _TH ) (S320) The procedure goes to the duration comparison step S370 and the apnea duration comparing step S380. If not, the third low respiration flag setting step S310 and the second apnea flag set confirmation step S350 are performed.

Third hypopnea flag whether or not a verification step sets, in a third comparing step of a hypopnea threshold, the amplitude of the respiratory cycle of the current breathing cycle and a subsequent before last of the (Amp [k-2]) is, hypopnea threshold (H _TH It is checked whether the low breath flag (State _H ) is set to 1 (S330). If it is not set to 1, the flow returns to the breathing signal receiving step (S105) The respiration counter Cnt _Hypop is increased (Cnt _Hypop ++) (S350), and the process returns to the breathing signal receiving step (S105).

The second apnea flag setting whether or not the second apnea flag is set is determined by comparing the amplitude (Amp [k-2]) of the respiratory cycle before the current breathing cycle with the low breathing threshold (H _TH ) It is checked whether the state _A is set to 1 in step S340. If it is not set to 1, the process returns to the breathing signal reception step S105. If it is set to 1, (Cnt _Apnea ++) (Cnt _Apnea ++) (S360), and returns to the breathing signal receiving step (S105).

The low respiration duration comparing step may include comparing the current respiratory cycle with the amplitude of the respiratory cycle Amp [k-2] of the previous respiratory cycle in comparison with the third low respiratory threshold, if not less than the low respiratory threshold _TH It is determined whether the value of the low respiration counter Cnt _Hypop is greater than the low respiratory duration threshold DUR _{H in} step S370. If not, the process returns to step S 105 to receive the respiration signal. (TMP _Hypop ) and a low respiration counter value (Cnt _Hypop ) are stored in the low respiratory interval data (Hypop [i]).

Here, in Hypop [i] = (TMP _Hypop Cnt _Hypop ), i indicates the number of low respiratory intervals, that is, i is an index of low respiration. On the other hand, the value of the low respiration counter (Cnt _Hypop ) is to count the number of samples in the low breath interval to know the length of one low breath interval.

In the comparison step with the third low respiratory threshold, if the amplitude (Amp [k-2]) of the respiratory cycle following the current respiration cycle is not less than the low respiratory threshold ( _{TH TH} ) It is determined whether the value of the apnea counter Cnt _Apnea is greater than the apnea duration threshold DUR _{A in} step S380. If not, the process returns to the respiration signal reception step S105, The apnea start point (TMP _Apnea ) and apnea counter value (Cnt _Apnea ) are stored with apnea interval data (Apnea [i]).

The fourth low respiration flag set confirmation step S410 is a step of comparing the amplitude (Amp [k-1]) of the breathing cycle before the current breathing cycle to the low breathing threshold If it is not smaller than the breathing threshold value (H _TH ), it is confirmed whether the low breathing flag is already set to 1 (S410). If it is not set to 1, the breathing signal receiving step returns to the step S105, It is determined whether the value of the low respiration counter Cnt _Hypop is greater than the low breathing duration threshold DUR _{H in} step S420. If not, the process returns to step S 105 (TMP _Hypop ) and a low respiration counter value (Cnt _Hypop ) are stored in the low respiratory interval data (Hypop [i]).

The third apnea flag set confirmation step S450 may include comparing the amplitude of the respiratory cycle before the current breathing cycle Amp [k-1] with the second low breathing threshold value in step S310, If it is not smaller than the threshold value H _TH , it is confirmed whether the apnea flag has been set to 1 (S450). If it is not set to 1, it returns to the respiration signal receiving step (S105) It is determined whether the value of the counter Cnt _Apnea is greater than the apnea duration threshold DUR _A or not at step S460. If not, the process returns to the respiration signal reception step S105, (TMP _Apnea ) and the apnea counter value (Cnt _Apnea ) with the interval data (Apnea [i]).

In FIGS. 7A and 7B, no branch of the case of No is indicated in some conditional statements (indicated by rhombus), which indicates that the process returns to the breathing signal receiving step (S105). 7A and 7B, the next step of S200, S210, S220, S260, S270, S290, S250, S260, S390, S400, S430 and S470 indicates that the process returns to the breathing signal receiving step S105.

In the present invention, if the amplitude of the respiratory cycle is less than the low respiratory threshold (H _TH ), it is determined to be low respiration, and if the amplitude of the respiratory cycle is less than the apnea threshold value (A _TH ), it is determined to be apnea.

The low breath threshold (H _TH ) is obtained by obtaining the normal breath average of the subject obtained at the beginning of use and a predetermined ratio (for example, 70% to 50%) of the normal breath average. The low respiratory threshold (H _TH ) can be set to 60% of the normal respiration average obtained by obtaining the subject's normal breathing average at the beginning of use. Here, AVG _NORMAL (Average of Normal Breath) is the average respiration signal obtained from the recent 6 breaths (ie, 6 breathing cycles). That is, the hypopnea threshold (H _TH ) is AVG _NORMAL X 60%. In other words, the low breath threshold (H _TH ) = AVG _NORMAL X 0.6.

The apnea threshold value (A _TH ) is obtained by obtaining a normal breathing average of a subject obtained at the beginning of use and a predetermined ratio (for example, 15% to 5%) of the normal breathing average. The apnea threshold (A _TH ) can be set to 10% of the normal breathing average obtained by obtaining the subject's normal breathing average (AVG _NORMAL ) at the beginning of use. That is, the apnea threshold (A _TH ) can be calculated as AVG _NORMAL X 10%. In other words, the apnea threshold (A _TH ) = AVG _NORMAL X 0.1.

In the present invention, than that determine the breathing greater than the duration of hypopnea duration threshold (DUR _H) to and that detects a hypopnea a larger case, also, apnea duration of apnea duration threshold (DUR _A) And it is assumed that apnea is detected when it is larger.

The low respiration duration threshold DUR _H and the apnea duration threshold DUR _A may be values set at the time of shipment from the factory. In some cases, a user (subject, medical professional, etc.) And may be a value set by the user.

In the present invention, the application program installed in the subject terminal 200 can be used in the Android environment and plays an auxiliary role of the positive pressure sustainer for detecting sleep apnea. The user wears a positive pressure sustaining device at sleep and maintains the connection with the Android device. The subject terminal 200 can detect the degree of breathing measured in real time and can detect sleep apnea by the sleep apnea detection algorithm.

The arithmetic processing unit of the examinee terminal 200 determines whether the number of apnea occurrences is greater than or equal to a preset apnea number emergency threshold (for example, 5 to 10) for a predetermined period of time or an apnea duration exceeds a predetermined apnea threshold If you are in an emergency, contact your registered guardian, 119, etc. Preferably, when the sleep apnea occurs continuously for 5 to 6 times or more for a long time (about 2 minutes), the arithmetic processing unit of the examinee terminal 200 contacts the registered guardian 119 do.

Apnea frequency The emergency threshold and the apnea threshold can be set at the factory at the factory or set by the user at the beginning of use.

8 is an example of a result of detecting the apnea and low breathing events (i.e., the apnea and the low respiration intervals) in the calculation processing unit 250 of the subject terminal 200 of FIG.

8A is an example of a result of detecting an apnea event (i.e., an apnea interval), wherein a portion indicated by a red 'C' shape is an apnea event occurrence interval, that is, an apnea interval.

FIG. 9B shows an example of a result of detecting a low breathing event (i.e., a low breathing interval), wherein a portion indicated by a blue color is a low breathing event occurrence period, that is, a low breathing interval.

FIG. 9 is an example of a screen showing a state under measurement in the subject terminal 200 in FIG.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, Modification is possible. Accordingly, the spirit of the present invention should be understood only in accordance with the following claims, and all equivalents or equivalent variations thereof are included in the scope of the present invention.

100: sustained positive pressure maintaining device 101: nasal air providing means
107: sustain positive pressure maintaining controller 110: respiratory detection unit
150, 210: Transmitting / receiving unit 200:
250: operation processing unit 260:
270: memory unit 280: key input unit
300: Parental terminal

Claims (20)

A respiratory detection unit that is equipped or mounted on the sustained positive pressure retainer and detects the airflow of the subject's nasal cavity as a respiration signal;
And an arithmetic processing unit for receiving the respiration signal detected from the respiration detection unit by radio and detecting the number of times of the apnea interval, the low respiration interval, and the apnea interval in the received respiration signal;
And a sleep apnea state monitoring system. The method according to claim 1,
Wherein the subject terminal is any one of a smart phone, a node book, a mobile phone, and a smart pad. The method according to claim 1,
The operation processing unit of the examinee terminal,
Processing for removing high-frequency noise and baseline variation from the respiration signal received from the respiration detection unit,
A respiration signal having a maximum value is detected as a peak point in a respiration signal of a predetermined maximum threshold value or more among the preprocessed respiration signals and a respiration signal having a minimum value in a respiration signal below a predetermined minimum threshold value is detected as a peak trough point,
Wherein the difference between the peak point value and the trough point value at successive peak points and trough points is determined by the amplitude of the breathing cycle. The method according to claim 1,
The patient terminal is notified of the emergency situation to the pre-registered guardian terminal when the number of times of occurrence of the apnea interval is equal to or greater than the preset threshold value of the apnea number of breathers or the duration of the apnea interval exceeds the preset apnea threshold value , A sleep apnea condition monitoring system. The method of claim 3,
The operation processing unit of the examinee terminal,
If the amplitude of the respiratory cycle is less than the low respiratory threshold,
The low breath threshold (H _TH )
H _TH = AVG _NORMAL X 0.6
(However, AVG _NORMAL is the subject's normal breathing average)
And a sleep apnea state monitoring system. The method according to claim 6,
The operation processing unit of the examinee terminal,
If the amplitude of the respiratory cycle is less than the apnea threshold, it is determined to be apnea,
The low breath threshold (A _TH )
A _TH = AVG _NORMAL X 0.1
(However, AVG _NORMAL is the subject's normal breathing average)
And a sleep apnea state monitoring system. The method according to claim 6,
The operation processing unit of the examinee terminal,
Characterized in that a 40 point moving average filter is used to remove high frequency noise in the respiration signal. 8. The method of claim 7,
The operation processing unit of the examinee terminal,
Characterized in that a 30 point median filter is used to remove baseline variations in the respiration signal. The method according to claim 1,
Wherein the breathing air current detection sensor for detecting the nasal airflow in the breath detection portion is mounted on the nasal air providing means of the persistent positive pressure retainer mounted on the nose. And an arithmetic processing unit for receiving the air current of the subject's nasal cavity as a respiration signal from the respiration detecting unit mounted on the sustained positive pressure maintaining unit and detecting the number of times of the apnea interval, the low respiratory interval and the apnea interval in the received respiration signal The sleep apnea state monitoring system according to claim 1,
The operation processing unit of the examinee terminal,
Processing for removing high-frequency noise and baseline variation from the respiration signal received from the respiration detection unit,
A respiration signal having a maximum value is detected as a peak point in a respiration signal of a predetermined maximum threshold value or more among the preprocessed respiration signals and a respiration signal having a minimum value in a respiration signal below a predetermined minimum threshold value is detected as a peak trough point,
Characterized in that the difference between the value of the peak point and the value of the trough point at successive peak points and trough points is determined by the amplitude of the breathing cycle 11. The method of claim 10,
The operation processing unit of the examinee terminal,
If the amplitude of the respiratory cycle is less than the low respiratory threshold,
The low breath threshold (H _TH )
H _TH = AVG _NORMAL X 0.6
(However, AVG _NORMAL is the subject's normal breathing average)
Wherein the sleep apnea state monitoring system comprises: 12. The method of claim 11,
The operation processing unit of the examinee terminal,
If the amplitude of the respiratory cycle is less than the apnea threshold, it is determined to be apnea,
The low breath threshold (A _TH )
A _TH = AVG _NORMAL X 0.1
(However, AVG _NORMAL is the subject's normal breathing average)
Wherein the sleep apnea state monitoring system comprises: The nasal airflow of the subject's nasal cavity is received as a respiration signal from the respiration detection unit mounted on the sustained positive pressure retainer, the received respiration signal is temporarily stored in the memory unit, the temporarily stored respiration signal is read, and the respiration signal is read from the read respiration signal And an arithmetic processing unit for setting the low respiratory flag when the amplitude of the respiratory cycle is smaller than the low respiratory threshold value and setting the apnea flag when the amplitude of the respiratory cycle is smaller than the apnea threshold value The sleep apnea state monitoring system according to claim 1,
A breathing signal receiving step of reading the breathing signal from the memory unit of the arithmetic processing unit;
The arithmetic processing unit checks whether the respiration signal received in the respiration signal receiving step is a trough point, which is a respiration signal having a minimum value among respiration signals below a minimum threshold value. Trough point check step;
Determining whether the amplitude (Amp [k]) of the current breathing cycle, which is the breathing cycle including the current breathing signal, is less than the low breathing threshold, if the breathing signal is a trough point; 1 low breath threshold;
If the amplitude (Amp [k]) of the current breathing cycle is smaller than the low breathing threshold in the comparison with the first low breathing threshold, it is determined whether the amplitude (Amp [k]) of the current breathing cycle is smaller than the apnea threshold , A step of comparing with a first apnea threshold;
If the amplitude (Amp [k]) of the current breathing cycle is not less than the apnea threshold in the comparison with the first apnea threshold, the amplitude (Amp [k-1] If it is not smaller than the threshold, it is reset to zero and the apnea counter is cleared to zero. If the apnea flag is set to be 1, it is checked if the apnea flag is set to 1, A second apnea threshold value for storing the apnea threshold value TMP _Apnea and the apnea threshold value with the interval data Apnea [i];
If the amplitude (Amp [k]) of the current breathing cycle is not smaller than the apnea threshold in the comparison with the first apnea threshold, it is checked whether the low breathing flag has already been reset to 0, A low respiration flag reset step of setting a low respiration flag to 1 and storing a current breathing signal, that is, a time point of a current breathing signal, as a low breathing start point (TMP _Hypop );
Wherein the sleep apnea state monitoring system comprises: 14. The method of claim 13,
If the respiration signal is not a trough point, the arithmetic processing unit checks whether the low breath flag is already set to 1. If it is set to 1, the low-responder counter is incremented, and if it is set to 1, Determining whether the first low respiration flag is set, returning to the step;
If the respiration signal is not a trough point, it is checked whether or not the apnea flag is set to 1, and if it is set to 1, the apnea counter is increased, and the process returns to the respiration signal receiving step. 1 ascertaining whether or not the apnea flag is set;
Wherein the sleep apnea state monitoring system further comprises: 15. The method of claim 14,
If the amplitude (Amp [k]) of the current breathing cycle is smaller than the apnea threshold in the comparison with the first apnea threshold, it is checked whether the low breathing flag (State _H ) is already set to 1, A second low breathing flag set step of increasing the low breathing counter if it is set and returning to the breathing signal receiving step;
If the amplitude (Amp [k]) of the current breathing cycle is smaller than the apnea threshold in the comparison with the first apnea threshold, it is checked whether the apnea flag has already been reset to zero, and if not, Determining whether or not to reset the first apnea flag if the apnea counter has been reset and has been reset to 0, sets the apnea flag to 1, stores the time of the current breath signal at the apnea start point, ;
Wherein the sleep apnea state monitoring system further comprises: 16. The method of claim 15,
If the amplitude (Amp [k]) of the current breathing cycle is not less than the low breathing threshold in the comparison with the first low breathing threshold, the amplitude (Amp [k-1]) of the breathing cycle before the current breathing cycle is A second low respiratory threshold value for determining whether the low respiratory threshold value is less than the low respiratory threshold value;
If the amplitude (Amp [k-1]) of the breathing cycle before the current breathing cycle is smaller than the low breathing threshold in the comparison with the second low breathing threshold, the breathing cycle of the previous breathing cycle following the current breathing cycle A third low breath threshold to determine if the amplitude Amp [k-2] is less than the low breath threshold;
If the amplitude (Amp [k-2]) of the respiratory cycle after the current breathing cycle is smaller than the low breathing threshold in the step of comparing with the third low breathing threshold, the low breathing flag (State _H ) 1, if it is set to 1, increasing the low respiration counter and returning to the respiration signal receiving step;
If the amplitude (Amp [k-2]) of the respiratory cycle before the current breathing cycle is smaller than the low breathing threshold in the step of comparing with the third low breathing threshold, if the breathing flag has already been set to 1 Confirming whether or not the second apnea flag is set, ascertaining the apnea counter if it is set to 1 and returning to the respiration signal receiving step;
Wherein the sleep apnea state monitoring system further comprises: 17. The method of claim 16,
In the comparison with the third low respiratory threshold, if the amplitude (Amp [k-2]) of the respiratory cycle following the current breath cycle is not less than the low breath threshold, the value of the low breath counter (TMP _Hypop ) and the low breathing counter value are stored in the current (i-th) low breathing interval data (Hypop [i]), A low respiration duration comparison step;
If the amplitude (Amp [k-2]) of the respiratory cycle following the current breathing cycle is not less than the low breathing threshold in the step of comparing with the third low breathing threshold, the value of the apnea counter is set to the apnea duration threshold (TMP _Apnea ) and the apnea counter value (Cnt _Apnea ) with the current (i-th) apnea interval data Apnea [i] A returning, apnea duration comparing step;
Wherein the sleep apnea state monitoring system further comprises: 18. The method of claim 17,
If the amplitude (Amp [k-1]) of the breathing cycle before the current breathing cycle is not smaller than the low breathing threshold in the step of comparing with the second low breathing threshold, the low breathing flag is already set to 1 If it is set to 1, it is determined whether the value of the low respiration counter is larger than the low respiration duration threshold value. If it is larger than the low respiration interval threshold value, A fourth low respiration flag set step of storing a starting point of breathing (TMP _Hypop ) and a low breathing counter value (Cnt _Hypop ) and returning to a respiration signal receiving step;
If the amplitude (Amp [k-1]) of the breathing cycle before the current breathing cycle is not less than the low breathing threshold in the step of comparison with the second low breathing threshold, whether the breathing flag has already been set to 1 If it is set to 1, it is determined whether the value of the apnea counter is larger than the apnea duration threshold value. If the value is greater than the apnea threshold value, the apnea threshold value TMP (i) _Apnea ) and an apnea counter value (Cnt _Apnea );
Wherein the sleep apnea state monitoring system further comprises: 19. The method according to any one of claims 13 to 18,
The operation processing unit of the examinee terminal,
A respiration signal having a maximum value is detected as a peak point and a respiration signal having a minimum value in a respiration signal below a predetermined minimum threshold is detected as a trough in a respiration signal having a predetermined maximum threshold value or more, Point,
Characterized in that the difference between the value of the peak point and the value of the trough point at successive peak points and trough points is determined by the amplitude of the breathing cycle A recording medium storing a computer program source for a method of driving a sleep apnea monitoring system according to any one of claims 10 to 18.

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