KR20180072911A - Apparatus of treating for dry eye syndrome - Google Patents

Abstract

The present invention relates to a dry eye syndrome treatment device comprising a heating patch attachable to the region around an eyeball. To solve the above problem, the dry eye syndrome treatment device according to one embodiment of the present invention comprises a heating patch attachable to the region around an eyeball, wherein the heating patch includes, at least on a part thereof, a heating layer formed by electrospinning an emissive material containing at least one of nanomaterials and polymer materials. According to a heating sheet of the present invention, by comprising a heating patch capable of heating uniformly over the overall area, and by producing a heating patch in an attachable form, a device capable of effectively treating dry eye syndrome can be provided using a device generating heat on the eye or around the eye.

Description

[0001] Apparatus for treating dry eye syndrome [

The present invention relates to an apparatus for treating dry eye syndrome, and more particularly, to a dry eye syndrome treatment apparatus including a feather patch that can be attached to the periphery of an eyeball.

In the meibomian fissure in the conjunctiva of the eye (or eyeball), the fat that forms the fat layer, the outermost layer of the tear, is secreted. At this time, when the temperature of the my spring spring is lower than the normal, the moles of the my spring spring are closed and the fat is not smoothly secreted. As a result, as the amount of fat in the outermost layer of the tear decreases, dry eye syndrome occurs in which the aqueous layer of the tear evaporates faster than normal. Dry eye syndrome, also called dry eye syndrome or eye lid syndrome, is a multifactorial disorder that can be caused by changes in the tear film or corneal surface.

Our eyes, living in modern society, are exposed from various harmful factors. The use of computers, sleep deprivation, and various pollution causes the fatigue of the eyes of modern people to accumulate. When numerous capillaries around the eyes contract and become rigid, blood circulation around the eyes is not properly performed, oxygen supply to the organs of the eye is not smooth, eyes become congested or tears easily, And it becomes dry and stiff, and various uncomfortable symptoms are experienced.

Further, when eye diseases such as dry eye syndrome become worse, secondary pain such as headache may be experienced, which may result in a significant decrease in concentration on work or study.

Conventionally, in order to solve such a problem, eyeglass-shaped dry eye syndrome treatment apparatus as shown in FIG. 1 has been used. 1 is a perspective view schematically showing a conventional apparatus for treating dry eye syndrome.

Conventional dry eye treatment apparatuses are configured in the form of glasses so that the user can wear them on the face, and the magnetic field generating apparatus built in the treatment apparatus operates to indirectly apply a magnetic field to the eyeball (refer to prior art document 1).

According to the method of forming a magnetic field around the eyes, the symptoms of tear film destruction are improved. However, since this method is fundamentally different from the method of raising the temperature around the eyes, the improvement effect of dry eye syndrome is expected There is a limit to the difficulty.

Even if a heating device is incorporated in the treatment device for treating dry eye syndrome as shown in FIG. 1 instead of the magnetic field generating device, the distance between the heating device and the eye is considerably different from each other.

In addition, there is a limit to limit the activity of the user because the device is very inconvenient to use due to the characteristics of a device including a large volume including various structures, and the device is invisible when it is worn.

1. Korean Patent Publication No. 10-2015-0028893 (entitled " Dry eye syndrome treatment apparatus "

SUMMARY OF THE INVENTION It is an object of the present invention to provide an apparatus for treating dry eye syndrome using a device for generating heat in the vicinity of an eye or an eye.

Another object of the present invention is to provide an apparatus for treating dry eye syndrome comprising a heat generating sheet capable of being attached to the eyes or the eyes by forming a flexible heating layer with improved flexibility and preventing disconnection.

The problems of the present invention are not limited to the above-mentioned problems, and other problems not mentioned can be clearly understood by those skilled in the art from the following description.

According to an aspect of the present invention for solving the above problems, there is provided an apparatus for treating dry eye syndromes comprising a heat-generating patch adherable to the periphery of an eye, wherein the heat- And a heat generating layer formed by electrospinning a spinning material containing at least one of the polymer material.

According to another aspect of the present invention, the heating layer may be configured to be electrically connected at a point where a plurality of nano heat generating fibers formed by electrospinning the radiating material intersect with each other to form a network.

According to still another aspect of the present invention, the heating patch may further include an adhesive layer that allows the heating patch to adhere to the eyes or the eyes.

According to another aspect of the present invention, the nanomaterial may be silver nanoparticles.

According to another aspect of the present invention, the density of the nano-exothermic fiber can be determined so that when the voltage is applied to the exothermic layer of 1 to 12 V, the patch generates heat in a temperature range of 10 ° C to 60 ° C.

According to another aspect of the present invention, the nano-exothermic fiber may be formed to occupy 2 to 70% of the area of the patch.

According to still another aspect of the present invention, the heating layer can be co-electrospinning the radiation material.

According to the apparatus for treating dry eye syndrome of the present invention, a heat generating patch capable of performing a uniform heat generating function in an overall area is included, and a device capable of generating heat in the vicinity of the eye or eye is used Thereby providing an apparatus capable of effectively treating dry eye syndrome.

In addition, even if a separate member such as a frame in the form of a spectacle is not provided, it is possible to effectively treat dry eye syndrome and provide a light weight dry eye syndrome treatment apparatus.

Further, the heat generating layer of the heat-generating patch can be provided in a form that improves the flexibility and can prevent disconnection, thereby providing a more stable dry eye treatment apparatus.

1 is a perspective view schematically showing a conventional apparatus for treating dry eye syndrome.
2 is a perspective view schematically showing an apparatus for treating dry eye syndrome of the present invention.
Fig. 3 is a perspective view schematically showing a heat generating patch included in the apparatus of Fig. 2; Fig.
FIG. 4 is a schematic view showing the use of the device for treating dry eye syndrome of FIG. 2; FIG.
5 is a perspective view schematically showing a heat generating layer of the present invention and nano heat generating fibers included therein.
6 is a block diagram schematically showing an electrospinning device for producing nano-calorific fiber and a method for producing nano-calorific fiber using the device.
7 is a cross-sectional view schematically showing the shape of a nozzle that can be used in the electrospinning apparatus of FIG.

BRIEF DESCRIPTION OF THE DRAWINGS The advantages and features of the present invention, and the manner of achieving them, will be apparent from and elucidated with reference to the embodiments described hereinafter in conjunction with the accompanying drawings. The present invention may, however, be embodied in many different forms and should not be construed as being limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. Is provided to fully convey the scope of the invention to those skilled in the art, and the invention is only defined by the scope of the claims.

It is to be understood that elements or layers are referred to as being "on " other elements or layers, including both intervening layers or other elements directly on or in between.

Although the first, second, etc. are used to describe various components, it goes without saying that these components are not limited by these terms. These terms are used only to distinguish one component from another. Therefore, it goes without saying that the first component mentioned below may be the second component within the technical scope of the present invention.

Like reference numerals refer to like elements throughout the specification.

The sizes and thicknesses of the individual components shown in the figures are shown for convenience of explanation and the present invention is not necessarily limited to the size and thickness of the components shown.

It is to be understood that each of the features of the various embodiments of the present invention may be combined or combined with each other partially or entirely and technically various interlocking and driving is possible as will be appreciated by those skilled in the art, It may be possible to cooperate with each other in association.

Hereinafter, an apparatus for treating dry eye syndrome according to the present invention will be described in detail with reference to FIGS. 2 and 3 attached hereto.

1. Composition of dry eye syndrome treatment device

FIG. 2 is a perspective view schematically showing an apparatus for treating dry eye syndrome of the present invention, FIG. 3 is a perspective view schematically showing a heat-generating patch included in the apparatus of FIG. 2, As shown in Fig.

Referring to FIG. 2, an apparatus 1000 for treating dry eye syndrome of the present invention includes a heating device 100 and a power device 200 that supplies power to a heating patch 100.

3 (a) and 3 (b), the heat generating patch 100 includes a sheet 110, a heat generating layer 120 formed on one surface of the sheet 110, a heat generating layer And an adhesive layer 130 formed on a surface opposite to the surface on which the first electrode 120 is formed.

The sheet 110 is formed of a heat-resistant material capable of stably holding heat generated in the heat-generating layer 120 and an insulating material such as glass fiber, synthetic fiber, natural fiber, synthetic leather, natural Leather, synthetic resin, or a combination thereof.

For example, in order to secure the flexibility of the heating patch 100 of the present invention as shown in FIG. 3 (b), the sheet 110 may be made of a cotton, polyester, rayon material It can be formed of a flexible material. However, it is needless to say that the sheet 110 is not limited to the above-mentioned material, and a known sheet material used for forming the heat generating sheet may be used.

The heat generating layer 120 is a layer that generates heat by electrical resistance and is formed on one surface of the sheet 110 including a plurality of nano heat generating fibers 121.

The nano-calorific fibers 121 and the heat generating layer 120 including the nano-calorific fibers 121 can be stably bound to one surface of the sheet 110. [ Therefore, the heat generating sheet 100 of the present invention includes the nano heat generating fibers 121 and the heat generating layer 120 including the nano heat generating fibers 121, thereby having improved flexibility and electrical stability as compared with the case of using the conventional heat generating plate or heat generating coil as a heat generating layer. .

The nano-calorific fiber 121 is formed by electrospinning a spinning material containing at least one of a nanomaterial and a polymer material. Specific details of the nano-heat generating fiber 121 and the heat generating layer 120 will be described later with reference to Figs. 5 to 7.

The adhesive layer 130 is formed on the surface of the sheet 110 opposite to the surface on which the heating layer 120 is formed.

The adhesive layer 130 is a layer that allows the heat generating patch 100 to adhere to the eyes or around the eyes as shown in Fig. 4, in which adhesives attachable to the skin are applied to the sheet 110 Layer. Further, the adhesive layer 130 may be formed by attaching a separate film formed of such a pressure-sensitive adhesive to one surface of the sheet 110.

The adhesive layer 130 may be made of an adhesive material having adhesiveness and heat resistance capable of stably holding heat generated in the heat generating layer 120 and insulating material electrically insulating the heat generating layer 120 from the outside desirable. Further, it is preferable that the adhesive material is selected so that the heating patch 100 of the present invention can be used semi-permanently, even if the adhesive material is repeatedly adhered and detached a plurality of times.

The adhesive layer 130 may be formed of a hot-melt adhesive of a material such as acrylic or silicone. However, since this is an example, the adhesive layer 130 is not limited to the above-described ones, but may be formed of a known adhesive material having adhesiveness, heat resistance, and insulation.

Alternatively, although not shown in the heating patch 100 of FIG. 3, the protective layer 140 may be optionally formed to surround at least a part of the heating patch 100.

The protective layer serves to function as a heat insulating layer to prevent heat generated in the heat generating layer from being lost to the outside and to function as a waterproof layer to prevent moisture permeation to the heat generating layer.

The heat generated by the heat generating layer 120 is prevented from being lost to the outside and the heat generated by the heat generating layer 120 and the sheet 110 It is possible to effectively prevent moisture from permeating. More preferably, the protective layer is formed to be in close contact with the heat generating layer 120 and the entire sheet 110.

Such a protective layer can be formed of a Teflon resin which is resistant to external impact such as friction, as well as incombustibility, water resistance and heat resistance. The protective layer may be formed by applying a liquid Teflon resin so as to cover the heating layer 120 and the sheet 110. The protective layer may be formed by thermally compressing the Teflon resin of the film type by a hot press using an automatic press, Or may be formed by pressing to cover the sheet 110.

Referring again to FIG. 2, the power supply unit 200 is configured to be electrically connected to the heating layer 120 to supply power to the heating layer 120.

The power supply unit 200 includes a power supply unit 210 for supplying power and a power supply 220 connected to one end of the heating layer 120 and the power supply unit 210. The core wire of the uncoated wire 220 is connected to one end of the heating layer 120 and the power supply unit 210 so that power is supplied from the power supply unit 210 to the nano- .

It is needless to say that the power supply device 210 and the electric wire 220 are not specifically limited in the present invention, and a known configuration can be adopted.

Hereinafter, the structure of the nano-exothermic fiber forming the heat-generating layer included in the present invention and the method of producing the nano-exothermic fiber will be described in detail with reference to FIGS. 5 to 7.

2. On the exothermic layer  Composition of nano-exothermic fibers included

5 is a perspective view schematically showing a heat generating layer 120 of the present invention and nano heat generating fibers 121 (hereinafter referred to as 'F') included therein.

Referring to FIG. 5, the heat generating layer is formed by including a plurality of nano heat generating fibers F.

The nano-exothermic fibers 121 are electrically connected to each other at points N intersecting with each other, so that a plurality of nano-calorific fibers F can form a network and current can flow.

The nano-exothermic fibers (F) may be formed to have a diameter ranging from about 50 nm to 1 mu m and a length ranging from several mu m to several hundred mu m.

Due to the nature of such a fine and flexible nano-calorific fiber F, the heat-generating layer formed by including the nano-calorific fiber 121 can be easily damaged by an external force such as folding or bending, thus securing electrical safety.

At this time, the density of the formed nano-calorific fibers 121 may be determined so that the heating layer 120 generates heat in a temperature range of 10 ° C to 60 ° C when a voltage of 1V to 12V is supplied to the heating layer 120. The nano heat generating fibers 121 may be formed to occupy 2 to 70% of the area of the heat generating layer 120 in order to configure the heat generating layer 120 to satisfy the performance condition.

3. Manufacturing method of nanofiber fiber

6 is a block diagram schematically showing an electrospinning device for producing nano-calorific fiber and a method for producing nano-calorific fiber using the device, and Fig. 7 is a cross-sectional view of a nozzle used for the electrospinning device of Fig. 6 Sectional view schematically showing the shape of the semiconductor device.

Electrospinning device

6, the electrospinning device 1 includes a spinning solution tank 10, a spinning nozzle 20, an external power source 30, and a collector substrate 40.

The spinning solution tank 10 stores the spinning solution. The spinning solution tank 10 can pressurize the spinning solution using a built-in pump (not shown) to provide the spinning solution to the spinning nozzle 20.

The spinning nozzle 20 receives the spinning solution from the spinning solution tank 10 and emits the spinning solution. The spinning nozzle 20 emits the spinning solution by the voltage applied by the external power source 30 after the spinning solution is pressurized by the pump to fill the nozzle tube therein.

Here, as the spinning nozzle 20, a single nozzle 20a as shown in FIG. 7 (a) may be used, or a double nozzle 20b as shown in FIG. 7 (b) may be used.

Two types of spinning nozzles can be selectively used depending on the structure of the nano-exothermic fibers (F) included in the heat generating layer of the present invention. The manufacturing process of the nano-exothermic fiber (F) using the single nozzle (20a) or the double nozzle (20b) and the structure of the produced nano-calorific fiber (F) will be described later.

The external power supply 30 provides a voltage such that the spinning solution is radiated to the spinning nozzle 20. The voltage may vary depending on the type of spinning solution and the amount of spinning. For example from about 100 V to about 30000 V, and can be DC or alternating current. The voltage applied by the external power supply 30 can radiate the spinning solution filled in the spinning nozzle 20. [

The collector substrate 40 is located below the spinneret and accommodates the spinning solution to be emitted. Collector substrate 40 may be grounded to have a voltage of 0V, which is the ground voltage, or collector substrate 40 may have a voltage opposite to spinneret 20. Since the spinning nozzle 20 is charged to a positive voltage or a negative voltage by the external power source 30 and thus the spinning solution is also charged, a voltage difference occurs with the collector substrate 40 having a grounded or opposite voltage do.

When a voltage is applied to the spinning nozzle 20 by the external power source 30, the spinning solution at the end of the spinning nozzle 20 is formed into a conical shape like a Taylor cone. At this time, an electric field in the range of about 50000 V / m to about 150000 V / m may be formed between the spinning nozzle 20 and the spinning solution. Due to the voltage difference, the spinning solution can be radiated to the collector substrate 40 and received.

By controlling the flow rate of the spinning solution and the difference in voltage between the spinneret 20 and the collector substrate 40, the diameter and length of the nano-calorific fiber structure 50 accommodated in the collector substrate 40 Can be controlled. For example, the nano-calorific fiber structure 50 emitted from the electrospinning device 1 described above may have a diameter in the range of about 50 nm to 1 μm and a length in the range of about several μm to several hundred μm.

Meanwhile, the positional relationship between the spinneret 20 and the collector substrate 40 in FIG. 6 is exemplary, and the technical idea of the present invention is not limited thereto.

For example, the collector substrate 40 may be positioned above the spinneret 20 and spinning solution may be radiated upwardly from the spinneret 20, and the collector substrate 40 may be spin- And the spinning solution radiated from the spinning nozzle 20 may be radiated in the horizontal direction. The electrospinning method according to various arranging methods of the spinning nozzle 20 and the collector substrate 40 can be included in the technical idea of the present invention. The collector substrate 40 is not limited to the planar substrate. However, it is needless to say that a drum-type collector that rotates about the center axis of the collector substrate 40 may be used.

Further, the spinning nozzle 20 can spin the spinning solution in a linear form, for example, in a wire form or a rod form (i.e., a spinning mode). On the other hand, the spinning nozzle 20 can spin the spinning solution in the form of a spray (i.e., a spray mode). The spinning solution has a viscosity of the solution, a weight ratio of the solute in the solution, And the molecular weight of the solvent, and may be radiated in different forms depending on the magnitude of the applied voltage. For example, if the spinning solution has a relatively high viscosity or a relative The electrospinning process can be performed by the spinning mode and the electrospinning process is performed by the spray mode when the spinning solution has a relatively low viscosity or a relatively high voltage is applied .

The spinning mode and the spraying mode can be performed in combination in the production of the nano-calorific fiber (F), and will be described in more detail in the following description of a method of manufacturing a heating layer according to a single spinning coating process.

Electrospun material

The nano-exothermic fibers forming the heat-generating layer included in the present invention are made of nanomaterials and high-molecular materials.

The nanomaterial may comprise a conductive material, for example, including a metal nanomaterial or may comprise a carbon nanomaterial.

Specifically, the nanomaterial may be at least one selected from the group consisting of Ag, Cu, Co, Sc, Ti, Cr, Mn, (Cu), zinc (Zn), yttrium (Y), zirconium (Zr), niobium (Nb), molybdenum (Mo), technenium (Tc), ruthenium (Ru) , Cadmium (Cd), hafnium (Hf), tantalum (Ta), tungsten (W), rhenium (Re), osmium (Os), iridium (Ir), platinum , Lanthanide, actinoid, silicon, germanium, tin, arsenic, antimony, bismuth, gallium, And indium (In).

Nanomaterials can be composed of materials having a variety of nanoscopic shapes and include, for example, nanoparticles, nanowires, nanotubes, nanorods, nanowalls, (nanobelt), and nanorring (nanoring).

These nanomaterials can be composed of solutions of nanomaterials dissolved in a soluble solvent. The soluble solvent may be selected from the group consisting of water, alcohols and mixtures thereof, and examples thereof include water, methanol, ethanol, propanol, isopropanol, butanol, acetone, tetrahydrofuran, toluene or dimethylformamide, dimethylsulfoxide, N, N-dimethylformamide, 1-methyl-2-pyrrolidone, trimethylphosphate, and mixtures thereof.

However, the nanomaterial and the nanomaterial solution described above are illustrative, and the technical idea of the present invention is not limited thereto.

The polymer nanofibers formed from the polymer material and the polymer material may include various high molecular materials.

For example, the polymeric material may be selected from the group consisting of polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), polymethyl methacrylate (PMMA), polydimethylsiloxane (PDMS), polyurethane, polyether urethane, cellulose acetate, cellulose (PA), polyacrylonitrile (PAN), polyperfuryl alcohol (PPFA), polystyrene, polyethylene oxide (PEO), poly (methyl methacrylate) And may include at least one selected from the group consisting of propylene oxide (PPO), polycarbonate (PC), polyvinyl chloride (PVC), polycaprolactone, polyvinyl fluoride and polyamide. The polymer material and the polymer nanofibers may include a copolymer of the above-mentioned materials, and examples thereof include polyurethane copolymers, polyacrylic copolymers, polyvinyl acetate copolymers, polystyrene copolymers, polyethylene oxide copolymers, poly Propylene oxide copolymers, and polyvinylidene fluoride copolymers. [0033] The term " copolymer "

Such a polymer substance may be composed of a solution of a polymer substance dissolved in a soluble solvent. The soluble solvent may be selected from the group consisting of water, alcohols and mixtures thereof, and examples thereof include water, methanol, ethanol, propanol, isopropanol, butanol, acetone, tetrahydrofuran, toluene or dimethylformamide, dimethylsulfoxide, N, N-dimethylformamide, 1-methyl-2-pyrrolidone, trimethylphosphate, and mixtures thereof.

However, the above-mentioned polymer material and polymer material solution are illustrative, and the technical idea of the present invention is not limited thereto.

Manufacturing process of nanofiber fibers by single spinning process

The specific process in which single emission is performed using the single nozzle 20a of Fig. 7 (a) is as follows.

First, a substrate for collecting the nano-calorific fiber structure 50 radiated from the single nozzle 20a is disposed. The substrate may be the collector substrate 40 of FIG. 6 or a separate substrate disposed on the collector substrate 40. In the case of a substrate separate from the collector substrate 40, the substrate may include the conductive material and have the same voltage state as the collector substrate.

The spinning solution supplied from the spinning solution tank 10 is electrospun onto the substrate.

The spinning solution used in the single spinning process may be the above-described nanomaterial solution or a mixed solution in which the solution of the polymer material is mixed with the nanomaterial solution described above. The spinning solution may be in a gel state.

The voltage applied during electrospinning may vary depending on, for example, the type of the nanomaterial, the type of the polymer material, the type of the substrate, the process environment, and the like, and may range, for example, from about 100 V to about 30,000 V.

The nano-calorific fiber structure 50 formed by electrospinning can be arranged to form a one-dimensional, two-dimensional or three-dimensional network structure that is formed on the substrate and overlapped and connected to each other. For example, the nano-calorific fiber structure 50 may form a one-dimensional network structure in which a plurality of linear-shaped structures are connected in parallel to each other and connected in a linear shape, and a plurality of linear- Dimensional network structure in which a plurality of linear structures are overlapped and connected to each other with a predetermined angle so as to form a three dimensional network A structure can be formed. Further, the nano-calorific fiber structure 50 may have a shape having a predetermined pattern, for example, a mesh shape, or may be arranged to have a web shape.

Next, an annealing process may be selectively performed to fix the deformation of the inside of the nano-calorific fiber structure 50 arranged on the substrate and to uniformly arrange the materials. The annealing can be performed by appropriately heating the nano-calorific fiber structure 50 in a predetermined temperature range by a heat treatment method in which the material is heated to a predetermined temperature and slowly cooled.

By increasing the bonding force between the nanomaterials included in the nano-calorific fiber structure 50 by the annealing process, the nano-calorific fiber structure 50 can be formed of the nano-calorific fiber F shown in Fig.

The annealing may be performed in an atmospheric air atmosphere, an inert atmosphere containing argon gas or nitrogen gas, or a reducing atmosphere containing hydrogen gas. The annealing process may be omitted as an option or may be performed stepwise several times.

Fabrication of nano-exothermic fiber by single spinning coating process

A specific process in which a single spin coating is performed using the single nozzle 20a of Fig. 7 (a) is as follows.

First, a substrate for collecting the nano-calorific fiber structure 50 radiated from the single nozzle 20a is disposed. The step of disposing the substrate is the same as in the above-described " method for manufacturing a nano-exothermic fiber according to a single spinning process "

The spinning solution supplied from the spinning solution tank 10 is electrospun onto the substrate.

The spinning solution used in the single spinning coating process may be a solution of a selected one of the nanomaterial solution and the polymer solution described above. The spinning solution may be in a gel gel state.

As described above in the 'method of manufacturing a nano-exothermic fiber according to a single spinning process,' the voltage applied during electrospinning can be changed according to the type of the nanomaterial, the type of the polymer material, the type of the substrate, Such as from about 100 V to about 30,000 V, for example.

Next, a coating layer is formed on the radiated nanofibers so as to surround at least a part of the radiated nanofibers by spray-spinning the nanofibers solution and another solution in the solution of the polymer solution and the electrospun solution.

As described above, since the spinning mode or the spray mode can be performed according to the magnitude of the voltage to be applied, depending on the viscosity of the spinning solution, the physical properties such as the solute and the kind of solution using the electrospinning device, By forming the coating layer in spray mode on the spun nanofibers, a dual nano-calorific fiber structure 50 configured to form different layers of nanomaterials and polymeric materials can be produced.

For example, the polymer fiber including the polymer material may be located on the inner side and the coating layer including the nanomaterial may be located on the outer side of the polymer fiber. Alternatively, the nanofiber including the nanomaterial may be located on the inner side A coating layer containing a polymer material may be formed in a double structure in which the coating layer is surrounded and surrounded by the nanofibers. Here, the coating layer may be formed to completely surround the radiated nanofibers, or may be formed so as to surround a part of the nanofibers emitted so that a part of the radiated nanofibers is exposed to the outside.

The nano-emissive fibrous structure 50 formed by the single spinning coating may be arranged to form a one-dimensional, two-dimensional or three-dimensional network structure formed by overlapping and connecting to each other on the substrate. By the annealing process described above, The exothermic fiber structure 50 may be formed of a nano-exothermic fiber F having a length in the range of about several micrometers to several hundreds of micrometers.

On the other hand, a sintering process may be performed to selectively remove the polymer material in the nano-calorific fiber structure 50 of the double layer. When the polymer material is removed by the sintering process, rod-type or hollow-type nano-calorific fibers can be produced.

That is, when the nano-calorific fiber structure 50 is formed to have a double-layer structure such that the polymer material surrounds the nanomaterial, when the polymer material is sintered and removed, finally the nano-calorific fibers F are formed do. On the other hand, when the nano-calorific fiber structure 50 is formed in a bilayer structure such that the nanomaterial is surrounded by the polymer material, when the polymer material is removed under sintering, the nano-calorific fiber F is finally formed in a rod shape.

The sintering method for removing the polymer material may be chemical sintering, light sintering and heat sintering.

The chemical sintering means sintering in such a manner that the polymer material is melted by impregnating a nano-exothermic fiber structure (50) in which a polymer material and a nanomaterial form a double layer in an organic solvent capable of melting a polymer material.

Here, the organic solvent may include all kinds of solvents capable of dissolving the polymer material. The organic solvent may be an alkane such as hexane, an aromatic such as toluene, an ether such as diethyl ether, an alkyl halide such as chloroform, an ester, an aldehyde, a ketone, an amine, an alcohol, an amide, And water. The organic solvent is, for example, acetone, fluoroalkane, pentane, hexane, 2,2,4-tricetylpentane, decane, cyclohexane, cyclopentane, diisobutylene, 1-pentene, carbon disulfide, carbon tetrachloride Chlorobutane, diisopropyl ether, 1-chloropropane, 2-chloropropane, toluene, trichlorobenzene, benzene, bromoethane, diethyl ether, diethyl sulfide, chloroform, But are not limited to, dichloromethane, 4-methyl-2-propanone, tetrahydrofuran, 1,2-dichloroethane, , At least one selected from the group consisting of dimethylsulfoxide, aniline, diethylamine, nitromethane, acetonitrile, pyridine, 2-butoxyethanol, 1-propanol, 2-propanol, ethanol, methanol, ethylene glycol and acetic acid One can be included.

The light sintering is performed by irradiating the light of a desired wavelength range (or the entire area) with a constant energy for 1 second to several seconds by using a xenon lamp or the like, thereby removing the polymer material for a short time using light and forming a network of nanomaterials .

In the photo-sintering process, light pulse, on-time, turn-off time, voltage and wavelength range are important control variables.

The light sintering may be performed within a few seconds, and thus may be repeatedly performed as needed.

The heat sintering means sintering in such a way that the polymer material is melted by heating the nano-exothermic fiber to a temperature range above the melting point of the polymer material.

For example, it is possible to heat-sinter at a high temperature of 500 ° C or higher to melt the polymer material and allow the nanomaterials to form networking with each other. However, when a general glass substrate or a plastic substrate having a low melting point is used, a process of heat sintering at a high temperature can not be used. Therefore, it is necessary to pay attention to the selection of the substrate when employing the heat sintering method.

Fabrication of nano-exothermic fibers by dual spinning process

The specific process in which the double spinning is performed using the double nozzle 20b of FIG. 7 (b) is as follows.

The dual nozzle 20b may include a first nozzle 21 for emitting a first radiation material and a second nozzle 22 for emitting a second radiation material. The first nozzle 21 is connected to a first tank 11 containing a first radiation material and the second nozzle 22 is connected to a second tank 12 containing a second radiation material. The double nozzles 20b allow the first and second radiation materials to be radiated simultaneously without mixing.

The double nozzle 20b includes a first nozzle 21 and a second nozzle 22 formed so as to surround the first nozzle 21 so that the distance between the first nozzle 21 and the second nozzle 22 Axis are coaxial double structure nozzles configured to coincide with each other. The double nozzle 20b of the present invention is not limited to the coaxial double nozzle but may be a double nozzle 20b in which the first nozzle 21 and the second nozzle 22 are arranged in parallel, It is needless to say that the nozzle can be changed into a double nozzle of the type.

First, a substrate for collecting the nano-calorific fiber structure 50 radiated from the double nozzle 20b is disposed. The step of disposing the substrate is the same as in the above-described " method for manufacturing a nano-exothermic fiber according to a single spinning process "

The first and second spinning solutions supplied from the first tank 11 and the second tank 12 are doubly electrospun on the substrate.

The first spinning solution can be simultaneously spinning the second spinning solution and have the same spinning length. Also, the second spinning solution may be radiated by surrounding the outer side of the first spinning solution, and the first spinning solution may be located inside the second spinning solution. Accordingly, the nano-calorific fiber structure 50 accommodated in the substrate may have a bilayer structure in which the first spinning solution is located inside and the second spinning solution surrounds the outer side of the first spinning solution.

Here, the first spinning solution may be a nanomaterial solution, the second spinning solution may be a polymer material solution, or the second spinning solution may be a polymer material solution and the second spinning solution may be a nanomaterial solution. As described above, the types of the first spinning solution and the second spinning solution may be selected depending on whether the nano-exothermic fiber to be manufactured according to the electrospinning process of the present invention is a rod type or a hollow type. .

In order to easily form the coaxial double layer nano-calorific fiber structure 50, it is preferable that the first spinning solution and the second spinning solution should not be mixed with each other, so that spinning is performed under the following conditions.

The injection and spinning speed of the second spinning solution on the outside may be equal to or larger than the injection and spinning speed of the first spinning solution on the inside. At least one of the first spinning solution and the second spinning solution needs to have conductivity, and the vapor pressures of the first spinning solution and the second spinning solution should be the same or similar. In addition, the viscosity of the first spinning solution must be equal to or greater than the viscosity of the second spinning solution.

For example, in the double spinning process of the present invention, the injection and spinning rate of the first spinning solution is in the range of 0.1 ml / hour to 1.5 ml / hour, the injection and spinning rate of the second spinning solution is in the range of 1.5 ml / hour to 3.5 ml / hour Lt; / RTI > However, such an injection rate is an exemplary one, and the technical idea of the present invention is not limited thereto.

According to the above-described 'method for producing a nano-exothermic fiber according to the double spinning process, the nano-calorific fiber structure 50 is formed in a double layer structure so that the polymer material surrounds the nanomaterial or the nanomaterial surrounds the polymer material. The nano-heat-generating fiber structure 50 may be arranged so as to form a one-dimensional, two-dimensional or three-dimensional network structure formed by being overlapped and connected to each other on the substrate. By the annealing process, (50) may be formed of nano-exothermic fibers (F) having a length in the range of about several micrometers to several hundreds of micrometers.

The thus formed double-layered nano-calorific fiber structure 50 may be formed of a rod-type or hollow-type nano-calorific fiber F by selectively sintering the polymer material. The sintering process is the same as the sintering process according to the 'method for manufacturing nano-exothermic fiber according to the single spinning coating process' described above, so a duplicated description will be omitted.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, You will understand. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.

1000 ... Dry eye syndrome treatment device
100 ... Fever patch
110 ... Sheet
120 ... Heating layer
121 ... Nano-thermal fibers
130 ... Adhesive layer
200 ... Power supply
210 ... Power supply
220 ... wire
One … Electrospinning device
10 ... Spinning solution tank
11 ... The first tank
12 ... The second tank
20 ... Spinning nozzle
20a ... Single nozzle
20b ... Double nozzle
21 ... The first nozzle
22 ... The second nozzle
30 ... External Power
40 ... Collector substrate
50 ... Nano-heating fiber structure

Claims (7)

A dry eye syndrome treatment device comprising a feather patch adherable to an eye or an eye,
Wherein the heating patch comprises a heating layer formed by electrospinning a radiation material containing at least one of a nanomaterial and a polymer material in at least a part of the region. The method according to claim 1,
Wherein the heating layer is configured to be electrically connected to a network at a point where a plurality of nano-calorific fibers formed by electrospinning the radiating material intersect with each other to form a network. The method according to claim 1,
Wherein the heat generating patch further comprises an adhesive layer for allowing the heat generating patch to adhere to the eyes or the eyes. The method according to claim 1,
Characterized in that the nanomaterial is silver nanoparticles. The method according to claim 1,
Wherein the density of the nano-exothermic fibers is determined so that the patch generates heat in a temperature range of 10 to 60 占 폚 when a voltage of 1 to 12 V is supplied to the heat generating layer. 6. The method of claim 5,
Wherein the nano-exothermic fiber is formed to occupy 2 to 70% of the area of the heat-generating patch. The method according to claim 1,
Wherein the heating layer is formed by co-electrospinning the radiation material.

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