KR20180053894A - Smart contact lens including stretchable hybrid substrate and manufacturing method of the same - Google Patents

Abstract

According to the present invention, a smart contact lens is manufactured with a hybrid substrate formed with a rigid substrate having a flexible substrate on which an antenna coil and a flexible electrode are put, a rectifier circuit, a light emitting display, and a biosensor thereon. Therefore, the smart contact lens is transparent and flexible to minimize a feeling of irritation to be wearable. Moreover, as the biosensor detects a bio-signal, the light emitting display is turned on and off to easily recognize an operation state of the biosensor.

Description

Technical Field [0001] The present invention relates to a smart contact lens including a stretchable hybrid substrate and a manufacturing method thereof,

The present invention relates to a smart contact lens including a stretchable hybrid substrate and a manufacturing method thereof, and more particularly, to a smart contact lens including a stretchable hybrid substrate provided with a biosensor and a light emitting device, To a contact lens and a method of manufacturing the same.

Generally, electronic devices are equipped with electronic devices on a rigid substrate. Recently, as the application fields of electronic devices are expanded, demands for flexible and stretchable electronic devices are increasing. In addition, there is an increasing interest in the development of next-generation electronic device technology for collecting user's biometric information in real time and visualizing collected information.

However, since conventional wearable biosensors use a lens-shaped plastic substrate, there is a problem that the wearable biosensors can not be actually worn, and a lot of sense of shearing and fatigue occurs when worn. Further, since the sensor and the antenna are made of opaque metal, there is a problem of visibility being obscured.

Also, even if a display device or the like is provided on a conventional stretchable substrate, there is a problem that destruction of functional layers, which occurs when the display device is stretched, leads to destruction of the entire device.

Korean Patent Publication No. 10-2015-0094248

SUMMARY OF THE INVENTION An object of the present invention is to provide a smart contact lens including a stretchable hybrid substrate having both elasticity and rigidity and being excellent in wearing comfort and minimizing the sense of rejection, and a method of manufacturing the same.

A method of manufacturing a smart contact lens including a flexible hybrid substrate according to the present invention includes the steps of: preparing a sacrificial layer including an antenna coil for wirelessly receiving and transmitting power from the outside, and a rectifying circuit for rectifying a voltage transmitted from the antenna coil; And forming a flexible electrode; Wherein the flexible substrate is coated with a rigid material and patterned to form a rigid substrate having the integrated circuit, and then the flexible material is coated and cured to form the rigid substrate, the antenna coil, and the flexible electrode Forming an embedded hybrid substrate; Removing the sacrificial layer; Forming a light emitting device on the rigid substrate exposed by inverting the hybrid substrate; Forming a protective film layer formed of a soft material to protect the antenna coil, the light emitting device, and the integrated circuit exposed in the hybrid substrate; Forming a sensing inlet so that a sensing material can be brought into contact with the biosensor on the protective film layer; Attaching the biosensor to the sensing inlet and connecting the integrated circuit and the light emitting device to complete an electronic circuit provided in the hybrid substrate; The hybrid substrate is placed in a concave lens lower mold, and then the lens material is filled, pressed with an upper mold for a convex lens, and cured to manufacture a smart contact lens embedded with the hybrid substrate.

According to another aspect of the present invention, there is provided a method of manufacturing a smart contact lens including a flexible hybrid substrate including an antenna coil for wirelessly receiving and transmitting power from the outside on a sacrificial layer, and a rectifying circuit for rectifying a voltage transmitted from the antenna coil Forming an electronic circuit including an integrated circuit, an elastic electrode, a biosensor, and a light emitting element; A plurality of rigid substrates each having the integrated circuit, the biosensor, and the light emitting device are formed by coating and patterning a rigid material on the integrated circuit, the biosensor, and the light emitting device, Forming a hybrid substrate having the rigid substrate, the antenna coil, and the flexible electrode embedded in the flexible material; Removing the sacrificial layer to complete an electronic circuit provided in the hybrid substrate; Forming a protective film layer formed of a soft material so as to protect the electronic circuit exposed by inverting the hybrid substrate; Forming a sensing inlet to allow the sensing material to contact the biosensor on the protective layer; Molding the hybrid substrate into a recessed lower mold for lens, filling the lens material, pressing the lens mold with a convexly formed upper mold for lens, and curing the hybrid mold to manufacture a smart contact lens embedded with the hybrid substrate, And a hybrid substrate.

A smart contact lens according to the present invention includes a rigid substrate embedded in a contact lens and patterned by a rigid material in a predetermined pattern and a flexible substrate formed by filling a space between the patterns of the rigid substrate with a flexible material, Claims [1] An antenna coil provided on the flexible substrate and formed in a ring shape having openings spaced from each other at both ends so as to wirelessly receive and transmit power; An integrated circuit including a rectifying circuit provided on the rigid substrate, the rectifying circuit being located in an opening of the antenna coil and rectifying a voltage transmitted from the antenna coil; A biosensor provided on the rigid substrate, the biosensor being exposed to a surface of the substrate to reduce a resistance upon contact with the sensing material, thereby detecting the sensing material; And a light emitting device provided on the rigid substrate and displaying an operation of the biosensor on or off depending on whether the sensing material is in contact with the biosensor.

INDUSTRIAL APPLICABILITY By forming a smart contact lens using a hybrid substrate composed of a flexible substrate on which an antenna coil and an elastic electrode are placed and a rigid substrate on which a rectifier circuit, a light emitting element and a biosensor are placed, the present invention has transparency and stretchability, The feeling of fit can be improved.

Further, since the rectifier circuit, the light emitting element, and the biosensor are integrated and arranged, and the antenna coil is formed of the silver nanofibers, the phenomenon of hiding the field of view is minimized and the application to the contact lens is easier.

Further, by forming the transparent protective film layer, the exposure by the eyeball and the external environment can be minimized and the durability can be improved.

In addition, since the light emitting element is turned on or off according to whether the biosensor detects the biological signal, the operating state of the biosensor can be easily recognized.

1 is a view schematically showing a method of manufacturing a smart contact lens according to a first embodiment of the present invention.
2 is a flowchart schematically showing a method for manufacturing the smart contact lens shown in FIG.
FIG. 3 shows the voltage transmitted through the antenna coil and antenna coil shown in FIG. 1A.
Fig. 4 is a view showing the stretchability of the hybrid substrate shown in Fig. 1F.
5 is a view showing an example of an equivalent circuit for an electronic circuit of a smart contact lens according to the first embodiment of the present invention.
6 is a graph illustrating changes in current applied to the light emitting device of the smart contact lens according to the first embodiment of the present invention.
7 is a view showing another example of an equivalent circuit for an electronic circuit of a smart contact lens according to the first embodiment of the present invention.
8 is a view showing a wearing state of the smart contact lens according to the first embodiment of the present invention.
FIG. 9 shows a test result of the thermal stability test of the smart contact lens according to the first embodiment of the present invention.
10 is a view schematically showing a method of manufacturing a smart contact lens according to a second embodiment of the present invention.
11 is a flowchart schematically showing a method of manufacturing the smart contact lens shown in Fig.
12 is an equivalent circuit diagram of an electronic circuit of a smart contact lens according to a third embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings.

The smart contact lens including the stretchable hybrid substrate according to the embodiment of the present invention is a transparent hybrid substrate having stretchability, which imparts functionality for sensing biomedical signals to a contact lens by integrating transparent and stretchable electronic device technologies.

The smart contact lens is a lens that is manufactured by inserting a hybrid substrate 10 provided with an electronic circuit into a lens mold 90, filling a material for a lens, pressing it, and curing it at high temperature.

The hybrid substrate 10 includes a rigid substrate 11 formed of a rigid material and a flexible substrate 12 formed of a stretchable material.

The rigid substrate 11 is provided with an integrated circuit 40 including a rectifying circuit 30, a biosensor 50, and a light emitting element 60. That is, the rigid substrate 11 is provided with elements for ensuring rigidity.

The rigid substrate 11 is formed of a rigid material and patterned in a predetermined pattern. The rigid material may use at least one of SU-8, Ormocore, polyimide, and glass. The pattern is set to be suitable for the position of the integrated circuit 40, the biosensor 50, and the light emitting element 60 disposed on the rigid substrate 11.

The flexible substrate 12 is provided with an antenna coil 20 and a flexible electrode 70. Flexible elements are disposed on the flexible substrate 12. The antenna coil 20 and the elastic electrode 70 are formed of a metal nano-based material and are made of a transparent and stretchable material.

The soft substrate 12 is coated with a soft material on the surface of the sacrificial layer 2 and the antenna coil 12 while filling a gap formed between the patterns of the rigid substrate 11. The flexible material is a stretchable material, and at least one of PDMS (Polydimethylsiloxane), Ecoflex, hydrogel (hydrogel), Nusil, rubber material, and Parylene can be used.

The antenna coil 20 is a power transmission coil for wirelessly receiving electric power from the outside and transmitting electric power to the rectifying circuit 30. [ The antenna coil 20 is disposed on the flexible substrate 12. The antenna coil 20 is formed in a ring shape having openings 20a at both ends thereof. The antenna coil 20 is formed to include at least one of a metal nanowire, a metal nanofiber, a metal nanotrough, and a metal nano-mesh, and is transparent and stretchable. In the present embodiment, the antenna coil 20 is formed of silver nanofibers, for example.

The integrated circuit (40) is provided on the rigid substrate (11). The integrated circuit 40 includes a rectifying circuit 30 which is located in an opening of the antenna coil 20 and rectifies the voltage transmitted from the antenna coil 20. The rectifying circuit 30 is an electric circuit for converting alternating current into direct current.

The biosensor (50) is provided on the rigid substrate (11). In this embodiment, the biosensor 50 is a glucose sensor including a channel 50a coated with a glucose oxidase (GODox) that reacts with glucose contained in tears. For example, Explain. However, the present invention is not limited thereto, and the biosensor 50 may be a sensor capable of measuring a biological signal such as an intraocular pressure sensor.

The light emitting device 60 is provided on the rigid substrate 11. The light emitting device 60 uses either an OLED or an LED.

The light emitting device 60 is connected to the biosensor 50 in series or in a parallel circuit. When the voltage rectified in the rectifying circuit is higher than a set value, the light emitting diode 60 emits light, And is turned off when it is increased. That is, the light emitting device 60 can be automatically turned on or off according to the current flowing through the rectifying circuit 30 or the biosensor 50, thereby displaying the operating state of the biosensor 50.

1 is a schematic view illustrating a method of manufacturing a smart contact lens according to a first embodiment of the present invention. 2 is a flowchart schematically showing a method for manufacturing the smart contact lens shown in FIG.

Referring to FIGS. 1 and 2, a method of manufacturing a smart contact lens according to a first embodiment of the present invention will be described.

1A, a sacrificial layer 2 is formed on a mother substrate 1 by vacuum deposition, and the antenna coil 20, the elastic electrode 70, and the integrated circuit 40 (not shown) are formed on the sacrificial layer 2, (S1)

The sacrificial layer (2) is made of copper, for example. However, the present invention is not limited to this, and a lift-off resist (LOR), copper (Cu), nickel (Ni), aluminum (Al), polymer for laser lift- Alcohols, germanium (Ge), and polymethyl methacrylate (PMMA).

The antenna coil 20 is formed leaving a mounting portion of the light emitting device 60 and the biosensor 50 added in a subsequent process. The antenna coil 20 is formed in a ring shape having openings 20a at both ends thereof with a predetermined spacing therebetween. Since the antenna coil 20 is formed of silver nanofibers, the antenna coil 20 is manufactured in a transparent and stretchable manner, so that the visual sense is not disturbed, and the sense of foreign body when the smart contact lens 100 is worn can be minimized.

The integrated circuit 40 is disposed on one side of the opening 20a of the antenna coil 20. [ The integrated circuit (40) includes the rectifying circuit (30).

Referring to FIG. 1B, a hybrid substrate 10 based on a rigid material and a soft material is formed (S2)

The rigid substrate 11 is formed by coating a rigid material on the integrated circuit 40 and patterning the same. Also, the rigid substrate 11 is formed at a position where the light emitting device 60 and the biosensor 50 to be added are to be mounted in a subsequent process. That is, in this embodiment, a pattern is formed so as to form three rigid substrates 11, one of which is provided with the integrated circuit 40, and the other of which has the light emitting element 60 And the other one is provided with the biosensor 50 in a subsequent process.

After the rigid substrate 11 is formed, a soft material is applied and cured to form a soft substrate 12. The soft material covers the whole surface of the sacrificial layer 2 and the surface of the antenna coil 20 while filling the space between the patterns of the rigid substrate 11.

The hybrid substrate 10 in which the rigid substrate 11, the antenna coil 20, and the elastic electrodes 70 are all embedded is completed on the flexible substrate 12. That is, an electronic circuit including the antenna coil 20, the elastic electrode 70, and the integrated circuit 40 is embedded in the hybrid substrate 10 to be integrally formed. The hybrid substrate 10 is not a structure in which the flexible substrate 12 and the rigid substrate 11 are simply stacked and the rigid substrate 11 is embedded in the flexible substrate 12, Since the area of the rigid substrate 12 is much larger than the area of the rigid substrate 11, the hybrid substrate 10 itself can have sufficient stretchability.

1C, the sacrificial layer 2 may be removed and the hybrid substrate 10 may be peeled from the mother substrate 1. (S3)

In order to remove the sacrificial layer 2, the sacrificial layer 2 is etched by immersing the hybrid substrate 10 in an etching solution.

The etchant may be at least one of remover PG, photoresist developer, copper etchant, nickel etchant, laser, aluminum etchant, water, and acetone. However, the present invention is not limited thereto, and the etchant may be any material that can selectively remove the sacrificial layer 2. When the sacrificial layer material is copper, Ni etchant and Cu etchant may be used as the etchant. When the sacrificial layer material is nickel, Ni etchant and Cu etchant may be used as the etchant. Al etchant, Cu etchant, Ni etchant can be used as etchant when the sacrificial layer material is aluminum (Al), and laser can be used as etchant when the sacrificial layer material is a laser lift-off polymer. Water can be used as an etchant when the sacrificial layer is PVA (polyvinyl alcohol). Water can be used as an etchant when the sacrificial layer is germanium (Ge). When the sacrificial layer is polymethyl methacrylate (PMMA) Can be used.

When the sacrificial layer 2 is removed, the hybrid substrate 10 provided with the electronic circuit is peeled off. The hybrid substrate 10 has both elasticity and rigidity.

Referring to FIG. 1D, the hybrid substrate 10 is turned over. When the hybrid substrate 10 is turned over, a part of the rigid substrate 11 and the antenna coil 20 are exposed on the upper surface.

The light emitting device 60 is formed on the rigid substrate 11. (S4)

For example, the light emitting device 60 is an OLED. The light emitting device 60 may include a hole transporting layer, a light emitting layer, and an electron transporting layer. However, the present invention is not limited thereto. The light emitting device 60 may be formed through processes such as spin coating, vacuum thermal deposition, and inkjet printing.

The light emitting device 60 is electrically connected to the integrated circuit 30 by the elastic electrode 70.

Referring to FIG. 1E, a protective film layer 80 is formed on the hybrid substrate 10. (S5)

The encapsulation layer 80 is formed by thermal deposition or spin coating of a soft material. In this embodiment, Parylene is used as an example. The protective film layer 80 is a layer for protecting the exposed surfaces of the hybrid substrate 10 to protect the devices. The protective film layer 80 is formed to cover the exposed upper surface of the hybrid substrate 10.

Referring to FIG. 1E, a sensing inlet 80a is formed in the passivation layer 80. (S6)

The sensing inlet 80a is a hole for mounting the biosensor 50 and is a hole opened after the mounting of the biosensor 50 so that the sensing material can contact the biosensor 50. [ The sensing inlet 80a may be formed after the protective film layer 80 is formed or may be formed in the process of forming the protective film layer 80. [

1F, the biosensor 50 is provided at the sensing inlet 80a. (S7)

The biosensor 50 may be formed in the sensing inlet 80a or may be separately manufactured and then mounted. The biosensor 50 is electrically connected to the integrated circuit 40 and the light emitting device 60 through the elastic electrode 70.

The biosensor 50 is, for example, a blood glucose sensor. The biosensor 50 includes a pair of electrodes 50b and a channel 50a formed between the electrodes 50b and coated with a glucose oxidase.

Referring to FIG. 1G, the hybrid substrate 10 provided with the electronic circuit is completed. The hybrid substrate 10 can remove an unnecessary portion. That is, the hybrid substrate 10 may be cut in a circular shape to fit the shape of the contact lens, and the inner peripheral side of the antenna coil 20 may also be cut with a circular opening 16. Therefore, the hybrid substrate 10 provided with the electronic circuit is formed in a ring shape corresponding to the shape of the contact lens, and the area is minimized, so that the foreign object sensation can be minimized when the contact lens is worn.

1H and 1I, the hybrid substrate 10 is inserted into a lens mold 90 to form a smart contact lens. (S8)

The lens mold 90 includes a lower mold 91 for a lens having a concave groove and an upper mold 92 for a lens convexly formed in conformity with the groove of the lens lower mold 91.

After the hybrid substrate 10 is placed in the lens lower mold 91, the material for the lens forming the lens is filled. Thereafter, the hybrid mold is pressurized with the lens mold 92 and is cured at a high temperature, so that the hybrid substrate 10 is embedded and a contact lens having a shape suitable for wearing in the eye is manufactured.

The material for the lens is exemplified by using a hydrogel.

The pressure applied to the lens upper mold 92 is 300 to 350 kPa, the curing temperature may be set to 95 to 105 ° C, and the curing time may be set to 55 to 65 minutes. In this embodiment, the pressure applied by the upper mold 92 for lens is 313 kPa, and the curing is performed at 100 DEG C for about 1 hour, for example.

Referring to FIG. 1I, when the lens mold 90 is detached, the smart contact lens 100 embedded with the hybrid substrate 10 can be manufactured.

3 shows voltages transmitted through the antenna coil and the antenna coil shown in FIG. 1A.

3A, the antenna coil 20 formed on the flexible substrate 12 is shown.

3B shows the difference between the voltage V1 transmitted through the antenna coil 20 and the voltage V2 rectified through the rectifying circuit 30. FIG.

The voltage V1 transmitted via the antenna coil 20 is about 13 V and the voltage rectified through the rectifying circuit 30 is about 10 V. [ The voltage rectified due to the voltage drop due to the resistance inside the circuit is reduced.

Fig. 4 is a view showing the stretchability of the hybrid substrate shown in Fig. 1F.

Referring to FIG. 4, the hybrid substrate 10 is shown stretched in the direction of the arrow. When the hybrid substrate 10 is stretched, only the flexible substrate 12 is stretched without stretching the rigid substrate 11. Since the hybrid substrate 10 is in a state in which the rigid substrate 11 is embedded in the flexible substrate 12, the flexible substrate 12, which is much larger than the rigid substrate 11, It is possible to have elasticity, and cracks do not occur in the element placed on the rigid substrate 11 and the like.

5 is a view showing an example of an equivalent circuit for an electronic circuit of a smart contact lens according to the first embodiment of the present invention. 6 is a graph illustrating changes in current applied to the light emitting device of the smart contact lens according to the first embodiment of the present invention.

Referring to FIG. 5, the light emitting device 60 and the biosensor 50 are configured as a parallel circuit.

And the rectified voltage was 10 V through the rectifying circuit 30.

In the above experiment, the diode resistance Rdiode of the rectifying circuit 30 is 4 k?, The resistance Rdisplay of the light emitting element 60 when the light emitting element 60 is on is 4 k ?, and the sensor resistance Rsensor of the biosensor 50 is 6 k? , And the change width of the sensor resistance (Rsensor) at the time of sensing the sensing material was + 1kΩ.

Referring to FIG. 6, when the voltage rectified by the rectifying circuit 30 is 10 V, a voltage of about 4 V is supplied to the biosensor 50 and the light emitting device 60 due to the resistance of the diode, the voltage drop, .

A current is applied to the light emitting device 60 and the biosensor 50 by a rectified voltage through the rectifying circuit 30 before the sensing material contacts the biosensor 50, (60) is turned on. At this time, the current I1 flowing through the light emitting element 60 is about 70 μA, and the current flowing through the biosensor 50 is about 570 μA.

Meanwhile, when the sensing material contacts the biosensor 50, the sensor resistance is reduced. When the sensor resistance is decreased, the current flowing to the biosensor 50 is increased. As the current flowing through the biosensor 50 increases, the current flowing to the light emitting device 60 decreases. At this time, the current flowing in the biosensor 50 increases to 716 μA, and the current I 2 flowing to the light emitting device 60 decreases to 10 μA.

As the current flowing through the biosensor 50 increases, the current flowing to the light emitting device 60 is reduced, and the light emitting device 60 is turned off.

Therefore, the current flowing to the light emitting element 60 changes depending on whether or not the sensing material contacts the biosensor 50, so that the light emitting element 60 can be turned on or off. Therefore, The presence or absence of detection of the sensing material in the biosensor 50 can be confirmed on / off. That is, the operating state of the biosensor 50 can be known.

7 is a view showing another example of an equivalent circuit for an electronic circuit of a smart contact lens according to the first embodiment of the present invention.

Referring to FIG. 7, in the electronic circuit of the smart contact lens, the biosensor 50 and the light emitting device 60 may be formed of a series circuit.

When the biosensor 50 and the light emitting device 60 are constituted by a series circuit, the resistance of the diode in the rectifying circuit 30 and the resistance of the light emitting device 60, The resistance should be set very large. Therefore, the current can be sensitively changed in response to the change of the sensor resistance in the series circuit.

8 is a view showing a wearing state of the smart contact lens according to the first embodiment of the present invention.

When the smart contact lens 100 is worn, the light emitting element 60 is operated by the power transmitted from the outside wirelessly, so that the operating state of the smart contact lens 100 can be known.

Thereafter, when the sensing material contacts the biosensor 50, the biosensor 50 detects that the sensing material is detected because the light emitting device 60 is turned off.

FIG. 9 shows a test result of the thermal stability test of the smart contact lens according to the first embodiment of the present invention.

Referring to FIG. 9, when the light emitting device 50 operates, a certain amount of heat is generated. However, since the temperature generated by the light emitting device 50 is only about 30-1 ° C., the temperature is significantly lower than the human body temperature It does not affect the human body. In Fig. 9, the wireless display shows the light emitting element 50.

In the smart contact lens 100 manufactured as described above, the antenna coil 20 and the elastic electrode 70 are placed on the flexible substrate 12, and the rectifying circuit 30, the light emitting element 60, An element such as the biosensor 50 is placed on the rigid substrate 11 and an electronic circuit capable of accommodating mechanical deformation such as expansion and contraction by connecting the elements through the elastic electrode 70 Can be implemented.

Furthermore, the hybrid substrate 10 is formed of a transparent and stretchable material, and the feeling of wearing can be improved.

In addition, since the rectifying circuit 30, the light emitting device 60, the biosensor 50, and the like are integrated and arranged, the phenomenon of hiding the visual field is minimized and the application to the contact lens is facilitated.

Further, by forming the transparent protective film layer, the exposure by the eyeball and the external environment can be minimized and the durability can be improved.

In addition, the light emitting device 60 can be turned on or off according to whether a biological signal is detected, thereby easily recognizing the operation state.

In the embodiment of the present invention, the biosensor 60 is a blood sugar sensor, but the present invention is not limited thereto.

10 is a view schematically showing a method of manufacturing a smart contact lens according to a second embodiment of the present invention. 11 is a flowchart schematically showing a method of manufacturing the smart contact lens shown in Fig.

10 and 11, a method for manufacturing a smart contact lens according to a second embodiment of the present invention includes an antenna coil 120, an integrated circuit 140, an elastic electrode 170, Since the formation of both the biosensor 160 and the light emitting device 150 is different from that of the first embodiment, different configurations will be described in detail below.

10A, a sacrificial layer 102 is formed on a mother substrate 101 by vacuum deposition, and the antenna coil 120, the integrated circuit 140, the elastic electrode (not shown) 170, the biosensor 160, and the light emitting device 150 are all formed (S11)

The integrated circuit 140, the biosensor 160, and the light emitting device 150 are disposed at the opening of the antenna coil 120. The integrated circuit 140 includes a rectifying circuit.

10B, a hybrid substrate 10 based on a rigid material and a soft material is formed (S12)

The rigid substrate 111 is formed by coating and patterning a rigid material on the integrated circuit 140, the biosensor 160, and the light emitting device 150. The rigid substrate 111 includes a first rigid portion formed on the integrated circuit 140, a second rigid portion formed on the biosensor 160, and a third rigid portion formed on the light emitting device 150 . The first and second toughening portions are spaced apart from each other and the integrated circuit 140, the biosensor 160 and the light emitting device 150 are electrically connected to each other by the elastic electrode 170.

After the rigid substrate 111 is formed, a flexible substrate is coated and cured to form a flexible substrate 112. The soft material covers the whole surface of the sacrificial layer 102 while filling the space between the patterns of the rigid substrate 111.

Therefore, the hybrid substrate 110 in which the rigid substrate 111, the antenna coil 120, and the elastic electrodes 170 are all embedded in the flexible substrate 112 is completed. That is, an electronic circuit including the antenna coil 120, the elastic electrode 170, and the integrated circuit 140 is embedded in the hybrid substrate 110. The hybrid substrate 110 is not a structure in which the flexible substrate 112 and the rigid substrate 111 are simply stacked but has a structure in which the rigid substrate 111 is embedded in the flexible substrate 112, Since the area of the hybrid substrate 110 is much larger than the area of the rigid substrate 111, the hybrid substrate 110 itself can have sufficient stretchability.

10C, the sacrificial layer 102 may be removed to peel the hybrid substrate 110 from the mother substrate 101. (S13)

When the sacrificial layer 102 is removed, the hybrid substrate 110 provided with the electronic circuit is peeled off. The hybrid substrate 110 has both elasticity and rigidity.

10D, the hybrid substrate 110 is turned over to form a passivation layer 180. (S14)

When the hybrid substrate 110 is turned over, the antenna coil 120, the integrated circuit 140, the elastic electrode 170, the biosensor 160, and the light emitting device 150 are all exposed to the top surface .

The protective layer 180 is a layer for protecting the exposed surfaces of the hybrid substrate 110 to protect the devices. The passivation layer 180 is formed to cover the entire exposed upper surface of the hybrid substrate 110.

A sensing inlet 180a is formed in the protective film layer 180 at a position corresponding to the biosensor 150. (S15)

The sensing inlet 180a is a hole opened to allow the sensing material to contact the biosensor 150. [ The sensing inlet 180a may be formed after the passivation layer 180 is formed, or may be formed in the process of forming the passivation layer 180.

Referring to FIG. 10E, the hybrid substrate 110 provided with the electronic circuit is completed. The hybrid substrate 110 can remove unnecessary portions. That is, the hybrid substrate 110 may be cut in a circular shape to fit the shape of the contact lens, and the inner periphery of the antenna coil 120 may be cut so as to have a circular opening 116. Therefore, the hybrid substrate 110 provided with the electronic circuit is formed in a ring shape corresponding to the shape of the contact lens, and the area is minimized, so that the foreign object sensation can be minimized when the contact lens is worn.

10F and 10G, the hybrid substrate 110 is inserted into a lens mold 190 to form a smart contact lens (S17)

The lens mold 190 includes a lens lower mold 191 having a concave groove and an upper mold 192 for lens formed convexly in conformity with the groove of the lens lower mold 191.

After the hybrid substrate 110 is inserted into the lens lower mold 191, the material for the lenses forming the lens is filled. Thereafter, the lens is pressed by the upper mold for lens 192 and cured at a high temperature.

The pressure applied to the lens upper mold 192 may be set to 300 to 350 kPa, the curing temperature may be set to 95 to 105 ° C, and the curing time may be set to 55 to 65 minutes. In this embodiment, the pressure applied by the lens upper mold 192 is 313 kPa, and the curing is performed at 100 DEG C for about 1 hour, for example.

Referring to FIG. 2G, when the lens mold 190 is detached, the smart contact lens 200 embedded with the hybrid substrate 110 can be manufactured.

12 is an equivalent circuit diagram of an electronic circuit of a smart contact lens according to a third embodiment of the present invention.

12, in the electronic circuit according to the third embodiment of the present invention, the light emitting device 260 and the biosensor 250 constitute a Westone Bridge circuit, Since the light emitting device 260 is turned on when the material is detected, the different configurations will be described in detail, and description of the similar configurations and operations will be omitted.

The Wheatstone bridge circuit is connected in parallel to the rectifier circuit (30).

The first resistor R1 of the first, second, third, and fourth resistors R1, R2, R3, and R4 constituting the Wheatstone bridge circuit is set to the biosensor 250, 4 Resistors (R2, R3, R4) are set to predetermined resistances. The first resistor R1 and the third resistor R3 are connected in series and the second resistor R2 and the fourth resistor R4 are connected in series.

The first, second, third, and fourth resistors are connected in parallel with the light emitting device 260.

The first, second, third, and fourth resistors (R1 = R2 = R3 = R4 = R0) before the sensing material contacts the biosensor 250, V0) is equal to or less than the set value, the light emitting element 26 is in the off state.

After the sensing material contacts the biosensor 250, the resistance of the biosensor 250 decreases, so that the voltage applied to the light-emitting device 260 increases to turn on the light-emitting device 260 have.

When the initial input voltage is rectified to 10V or more, a voltage of at least 2V is applied to both ends of the LED, which is the light emitting device 260, so that the light emitting device 260 can be turned on.

As described above, by constructing the Wheatstone bridge circuit, it is possible not only to measure a minute resistance change but also to allow the light emitting element 260 to be turned on after the biosensor 250 detects the sensing substance, ) Can be intuitively understood.

While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. Accordingly, the true scope of the present invention should be determined by the technical idea of the appended claims.

2: sacrificial layer 10: hybrid substrate
11: Rigid substrate 12: Flexible substrate
20: antenna coil 30: rectifier circuit
40: integrated circuit 50: biosensor
60: light emitting element 70: stretchable electrode
80: Protective layer 100: Smart contact lens

Claims (15)

An integrated circuit including an antenna coil for wirelessly receiving and transmitting power from the outside on a sacrificial layer, and a rectifying circuit for rectifying a voltage transmitted from the antenna coil;
Wherein the flexible substrate is coated with a rigid material and patterned to form a rigid substrate having the integrated circuit, and then the flexible material is coated and cured to form the rigid substrate, the antenna coil, and the flexible electrode Forming an embedded hybrid substrate;
Removing the sacrificial layer;
Forming a light emitting device on the rigid substrate exposed by inverting the hybrid substrate;
Forming a protective film layer formed of a soft material to protect the antenna coil, the light emitting device, and the integrated circuit exposed in the hybrid substrate;
Forming a sensing inlet so that a sensing material can be brought into contact with the biosensor on the protective film layer;
Attaching the biosensor to the sensing inlet and connecting the integrated circuit and the light emitting device to complete an electronic circuit provided in the hybrid substrate;
Molding the hybrid substrate into a recessed lower mold for lens, filling the lens material, pressing with a convexly formed upper mold for the lens, and curing the hybrid mold to manufacture a smart contact lens embedded with the hybrid substrate, A method of manufacturing a smart contact lens including a hybrid substrate. An integrated circuit including an antenna coil for wirelessly receiving and transmitting power from the outside on a sacrificial layer, a rectifying circuit for rectifying a voltage transmitted from the antenna coil, and an electronic circuit including both a flexible electrode and a biosensor and a light- ; ≪ / RTI >
A plurality of rigid substrates each having the integrated circuit, the biosensor, and the light emitting device are formed by coating and patterning a rigid material on the integrated circuit, the biosensor, and the light emitting device, Forming a hybrid substrate having the rigid substrate, the antenna coil, and the flexible electrode embedded in the flexible material;
Removing the sacrificial layer to complete an electronic circuit provided in the hybrid substrate;
Forming a protective film layer formed of a soft material so as to protect the electronic circuit exposed by inverting the hybrid substrate;
Forming a sensing inlet to allow the sensing material to contact the biosensor on the protective layer;
Molding the hybrid substrate into a recessed lower mold for lens, filling the lens material, pressing with a convexly formed upper mold for the lens, and curing the hybrid mold to manufacture a smart contact lens embedded with the hybrid substrate, A method of manufacturing a smart contact lens including a hybrid substrate. The method according to claim 1 or 2,
In the step of manufacturing the smart contact lens,
And cutting the hybrid substrate in a ring shape before inserting the hybrid substrate into the lens lower mold. The method according to claim 1 or 2,
Wherein the light emitting element and the biosensor are constituted by a parallel circuit,
Before the sensing material is brought into contact with the biosensor, the rectified current is supplied to the rectifying circuit,
After the sensing material is brought into contact with the biosensor, the resistance of the biosensor is reduced, so that the current passing through the biosensor decreases due to the increase of the current flowing through the biosensor, A method for manufacturing a smart contact lens. The method according to claim 1 or 2,
Wherein the light emitting element and the biosensor are constituted by a series circuit,
The resistance of the diode of the rectifying circuit and the resistance of the biosensor are set larger than the resistance of the light emitting element,
Before the sensing material is brought into contact with the biosensor, the rectified current is supplied to the rectifying circuit,
After the sensing material is brought into contact with the biosensor, the resistance of the biosensor is reduced, so that the current passing through the biosensor decreases due to the increase of the current flowing through the biosensor, A method for manufacturing a smart contact lens. The method according to claim 1 or 2,
The light emitting device and the biosensor constitute a weststone bridge circuit,
Wherein the first resistor among the first, second, third and fourth resistors constituting the Wheatstone bridge circuit is set to the biosensor, the second, third and fourth resistors are set to predetermined resistances,
The first, second, third, and fourth resistors form a parallel circuit with the light emitting device,
Wherein before the sensing material is brought into contact with the biosensor, the voltage applied to the light emitting device is less than a predetermined value,
Wherein a voltage applied to the light emitting device is increased after the sensing material contacts the biosensor to turn on the light emitting device.

The method according to claim 1 or 2,
The antenna coil
A method for manufacturing a smart contact lens, the smart contact lens being formed in a ring shape having openings at both ends thereof. The method according to claim 1 or 2,
Wherein the biosensor is a blood glucose sensor including a channel for coating a glucose oxidase reacting with a concentration of glucose contained in a tear. The method according to claim 1 or 2,
In the step of manufacturing the smart contact lens,
The pressure applied to the lens upper mold is 300 to 350 kPa,
The curing temperature ranges from 95 < 0 > C to 105 &
And the curing time is set to 55 minutes to 65 minutes. The method according to claim 1 or 2,
Wherein the elastic electrode and the antenna coil are connected to each other,
A method for manufacturing a smart contact lens comprising at least one of a metal nanowire, a metal nanofiber, a metal nanotrough, and a metal nano-mesh. The method according to claim 1 or 2,
The rigid material includes at least one of SU-8, Ormocore, PI (polyimide), and glass,
Wherein the soft material comprises at least one of PDMS (Polydimethylsiloxane), Ecoflex, hydrogel (hydrogel), rubber material, and Parylene. A rigid substrate embedded in a contact lens and patterned by a rigid material in a predetermined pattern; and a flexible substrate formed by filling a space between the patterns of the rigid substrate with a flexible material;
An antenna coil provided on the flexible substrate and formed in a ring shape having openings spaced from each other at both ends so as to wirelessly receive and transmit power;
An integrated circuit including a rectifying circuit provided on the rigid substrate, the rectifying circuit being located in an opening of the antenna coil and rectifying a voltage transmitted from the antenna coil;
A biosensor provided on the rigid substrate, the biosensor being exposed to a surface of the substrate to reduce a resistance upon contact with the sensing material, thereby detecting the sensing material;
And a light emitting element provided on the rigid substrate, the light emitting element being turned on or off according to whether or not the sensing material is in contact with the biosensor to display an operation of the biosensor. The method of claim 12,
Wherein the light emitting device is connected to the biosensor in a parallel circuit,
Wherein the antenna coil is turned on when the voltage is received through the antenna coil and the rectifying circuit,
Wherein the biosensor is in contact with the sensing material to increase the current passing through the biosensor, thereby reducing the current flowing through the biosensor and turning off the biosensor. The method of claim 12,
Wherein the biosensor is a blood glucose sensor including a channel coated with glucose oxidase reacting with a concentration of glucose contained in a tear. The method of claim 12,
Wherein the light emitting element comprises at least one of an OLED and an LED.

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