KR20170143103A - Macro-capsule containing ceramide and cosmetic composition comprising the same for moisturizing - Google Patents

Abstract

The present invention relates to macrocapsules containing ceramide, and a moisturizing cosmetic composition comprising the same. Specifically, the present invention relates to macrocapsules which are formed during processes in which ceramide and an oil mixed with a lipid complex containing cholesterols, fatty acids, a higher alcohol, and silicone elastomers are heated and cooled, and the above components are recrystallized; and to a moisturizing cosmetic composition comprising the same. The macrocapsules of the present invention, due to containing silicone elastomers, are convenient to produce in macro sizes; have significantly increased ceramide capture capacity; and do not cause ceramide to precipitate even under severe conditions, thus exhibiting excellent stability.

Description

TECHNICAL FIELD [0001] The present invention relates to a macrocapsule containing a ceramide and a cosmetic composition for moisturizing the same,

TECHNICAL FIELD The present invention relates to a macrocapsule in which ceramide is captured and a cosmetic composition for moisturizing the same, more specifically, to a cosmetic composition for moisturizing comprising a mixture of a lipid comprising a cholesterol, a fatty acid, a higher alcohol and a silicone elastomer, The present invention relates to a macrocapsule produced by recrystallization of the components during cooling, and a cosmetic composition for moisturizing the composition.

Ceramide, known as the most important lipid component in the stratum corneum, is called a skin barrier that protects the skin. Ceramide, which inhibits water evaporation and combines with water to provide moisture to the skin, And provides an environment in which functions can be performed.

Basically, ceramide has a function of lipid barrier which suppresses the evaporation of water and a function to maintain a square structure of the stratum corneum. The skin stratum corneum is composed of brick-shaped multi-layered cells, and these keratinized cells are firmly bound by ceramides, cholesterol, and free fatty acids.

Despite these characteristics, however, ceramide has a problem that it disturbs the structure of emulsified interfacial membrane in the emulsified formulations and hinders the stability of the formulation and causes self-gelling, thereby changing the physical properties of the formulation with time, Has come. Therefore, there has been a problem in that a very small amount is used when prescribing moisturizing cosmetics, or only limited use is required for specific formulations.

Korean Patent No. 10-0837558 is an invention relating to a nanocapsule in which ceramide is captured, but since the size is a nanometer unit, it is difficult to visually confirm the capsule in which the ceramide is captured, and the cost for nanotization is high. Therefore, it is necessary to develop a macrocapsule which can be visually confirmed and has a high collection rate and captured ceramide.

Korean Patent No. 10-0837558

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned problems occurring in the prior art,

It is an object of the present invention to provide a macrocapsule comprising a ceramide, a lipid complex and an oil, wherein the lipid complex comprises cholesterol, a fatty acid, a higher alcohol and a silicone elastomer, and a lipid complex and a ceramide in the oil.

Another object of the present invention is to provide a moisturizing cosmetic composition comprising the lipid complex and the macrocapsule in which the ceramide is captured in the oil.

It is still another object of the present invention to provide a method for producing the aforementioned cosmetic composition for moisturizing.

In order to accomplish the object of the present invention, the present invention provides a lipid complex comprising a ceramide, a lipid complex and an oil, wherein the lipid complex comprises cholesterol, a fatty acid, a higher alcohol and a silicone elastomer, Capsules are provided.

The ceramide, lipid complex and oil may be included in a weight ratio of 1: 1 to 50:10 to 50.

The lipid complex may contain 0.01 to 5.0 parts by weight of cholesterol, 20 to 40 parts by weight of fatty acid, 1 to 10 parts by weight of a higher alcohol and 5 to 15 parts by weight of a silicone elastomer.

The diameter of the macrocapsule may be 100 to 1500.

Wherein the oil is selected from the group consisting of dimethicone, lauryl dimethicone, cyclopentasiloxane, cyclohexasiloxane, trisiloxane, methyltrimethicone, phenylmethicone, dimethicone polyol, dimethicone polyol acetate, silicone glycol copolyol, Dimethicol , At least one silicone oil selected from the group consisting of methylpolysiloxane, methylphenylpolysiloxane, dimethicone polyol methyl ether, methylcyclopolysiloxane, dimethylpolysiloxane, hexamethyldisiloxane and caprylylmethylpolysiloxane; And at least one hydrocarbon oil selected from the group consisting of isododecane, isohexadecane, squalane, hydrogenated polyisobutene, vaseline, paraffin, ceresin, and mineral oil; And combinations thereof.

The silicone elastomer may be selected from the group consisting of dimethicone / vinyl dimethicone crosspolymer, polysilicon-11, dimethicone crosspolymer, dimethicone / phage-10/15 crosspolymer, vinyl dimethicone / methicillosilsesquioxane crosspolymer, dimethicone / Polyglycerin-3 crosspolymer, diphenyl dimethicone / vinyl diphenyl dimethicone / silsesquioxane cross polymer, phage-10 dimethicone / vinyl dimethicone cross polymer, and lauryl dimethicone / polyglycerin- And the like.

The fatty acid may be selected from the group consisting of stearic acid, isostearic acid, oleic acid, palmitic acid, linoleic acid, lauric acid, undecanoic acid, neodecanoic acid, capric acid, caprylic acid, Acid, heptanolic acid, myristic acid, and combinations thereof.

The higher alcohol may be one selected from the group consisting of lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, cetostearyl alcohol, and combinations thereof.

The present invention provides a cosmetic composition for skin moisturizing comprising the macrocapsule.

The present invention relates to a process for the preparation of a cosmetic composition, comprising the steps of: a) uniformly dispersing a water-containing part in a vacuum emulsification tank containing water, a moisturizing agent and a binding agent, followed by heating to 70 to 80; Lipid complexes comprising cholesterol, fatty acids, higher alcohols and silicone elastomers; And c) heating the oil phase of step b) to a temperature of from 70 to 80, c) cooling the water phase of step a) to 30 to 50, d) And e) cooling the vacuum emulsion tank of step d) to 20 to 50. The liposomal composition of claim 1, wherein the lipophilic compound is selected from the group consisting of a lipid, a fatty acid, a higher alcohol and a silicone elastomer, And a macrocapsule in which ceramide is trapped in oil. The present invention also provides a method for producing a cosmetic composition for skin moisturizing of a transparent solubilized formulation.

Since the macrocapsule of the present invention includes a silicone elastomer, it is easy to produce the macrocapsule, the ceramide collection rate is remarkably increased, and the ceramide in the capsule is not precipitated even under severe conditions, so that the stability is excellent.

1 shows a macrocapsule according to the present invention.
Fig. 2 schematically shows a cross-linking point between the molecular chains of the silicone elastomer.

The present invention provides macrocapsules comprising ceramide, a lipid complex and an oil, wherein the lipid complex comprises cholesterol, a fatty acid, a higher alcohol and a silicone elastomer, and a lipid complex and a ceramide in oil.

The ceramide, lipid complex and oil may be contained in a weight ratio of 1: 1 to 50:10 to 50.

If the content of the lipid complex in the weight ratio of the ceramide, the lipid complex and the oil is less than 1 in the above range of 1 to 50, the lipid complex does not sufficiently capture the ceramide, so that the aqueous and oily parts in the cosmetic composition can be separated and the ceramide can be precipitated. If the content of the lipid complex exceeds 50 in the above range of 1 to 50, the content of the lipid complex is excessively large, so that the recrystallized particles aggregate together to form a large lump, so that it may not be possible to uniformly disperse the lipid complex in the water phase. In addition, the content of the lipid complex may range from 1 to 40, from 1 to 30, from 1 to 20, from 1 to 10, or from 1 to 5.

On the other hand, if the content of the oil in the weight ratio of the ceramide, the lipid complex and the oil is less than 10 in the range of 10 to 50, the macrocapsule may hardly be formed due to the low oil content. The formed capsules are not uniform in size, . If the content of ceramides exceeds 50 in the above range of 10 to 50, the content of oil is excessively large, so that ceramides and oils are not properly collected in the lipid composite during the recrystallization process, so that the oils may flocculate and float, It may escape from the capsule and the stabilization of the ceramide may fail.

The lipid complex may contain 0.01 to 5.0 parts by weight of cholesterol, 20 to 40 parts by weight of fatty acid, 1 to 10 parts by weight of a higher alcohol and 5 to 15 parts by weight of a silicone elastomer.

The macrocapsules are prepared using recrystallization properties of ceramides, lipid complexes and oils. The lipid composite includes a silicone elastomer. Since the silicone elastomer has a structure similar to a mesh network due to cross-linking between molecular chains as shown in FIG. 2, it is easy to collect spread ceramides, thereby increasing the amount of ceramide in the capsule , The precipitation of ceramide and fatty acid is prevented, the stability of the capsule itself is increased over time, and the cracking of the capsule during application is improved.

If the content of the silicone elastomer in the lipid composite is less than 5 parts by weight, the ceramide collection rate may decrease, the stability of the macrocapsule may be decreased, and the macro-size capsule production rate may decrease. On the other hand, if the content of the silicone elastomer in the lipid composite exceeds 15 parts by weight, the capsule size may become excessively large or the capsule may be agglomerated.

The diameter of the macrocapsule may be, but is not limited to, 100 to 1500, 200 to 1500, 300 to 1500, 400 to 1500, 500 to 1500, 600 to 1500, 700 to 1500, 800 to 1500, 900 to 1500, 1500.

The oil may be any oil in which the ceramide is soluble, including but not limited to dimethicone, lauryl dimethicone, cyclopentasiloxane, cyclohexasiloxane, trisiloxane, methyltrimethicone, phenylmethicone, dimethicone copolyol , Dimethicone copolyol acetate, silicone glycol copolyol, Dimethicol, Methylpolysiloxane, Methylphenylpolysiloxane, Dimethicone copolyol Methyl ether, Methylcyclopolysiloxane, Dimethylpolysiloxane, Hexamethyldisiloxane and Caprylylmethylpolysiloxane. One or more silicone oils selected from the group consisting of: And at least one hydrocarbon oil selected from the group consisting of isododecane, isohexadecane, squalane, hydrogenated polyisobutene, vaseline, paraffin, ceresin, and mineral oil; And combinations thereof.

The silicone elastomer includes, but is not limited to, dimethicone / vinyl dimethicone crosspolymer, polysilicon-11, dimethicone crosspolymer, dimethicone / phage-10/15 crosspolymer, vinyl dimethicone / methicosylsethquioxane cross Polymer, dimethicone / polyglycerin-3 crosspolymer, diphenyl dimethicone / vinyl diphenyl dimethicone / silsesquioxane cross polymer, phage-10 dimethicone / vinyl dimethicone cross polymer, and lauryl dimethicone / poly Glycerin-3 crosspolymer.

The fatty acid may be selected from the group consisting of stearic acid, isostearic acid, oleic acid, palmitic acid, linoleic acid, lauric acid, undecanoic acid, neodecanoic acid, capric acid, caprylic acid, Acid, heptanolic acid, myristic acid, and combinations thereof.

The higher alcohol may be one selected from the group consisting of lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, cetostearyl alcohol, and combinations thereof.

The present invention provides a cosmetic composition for skin moisturizing comprising the macrocapsule according to the present invention.

The cosmetic composition according to the present invention can be formulated into solutions, suspensions, emulsions, pastes, gels, creams, lotions and the like, and more specifically, it can be formulated into soft cosmetics, nutritional creams, massage creams, essences, .

The cosmetic composition may include, but is not limited to, 1 to 10% by weight of a moisturizer, 0.1 to 0.5% by weight of an increasing agent, 0.03 to 0.7% by weight of ceramide, 0.01 to 5.0 parts by weight of cholesterol, 20 to 40 parts by weight of fatty acid, 0.1 to 5% by weight of a lipid complex comprising 5 to 15 parts by weight of a silicone elastomer, and 0.1 to 5% by weight of an oil.

When the content of the ceramide is less than 0.03% by weight, the moisturizing effect of the ceramide is very small. When the content of the ceramide is more than 0.7% by weight, the dissolution of the ceramide is difficult and the ceramide aggregation phenomenon may occur.

If the content of the acrylate / C-10-30 alkyl acrylate crosspolymer is less than 0.1% by weight in the cosmetic composition, the viscosity is not properly formed and the recrystallization process is performed properly. The ceramide macrocapsule can not be formed and if it is contained in an amount exceeding 0.5% by weight, the viscosity is too high and the ceramide macrocapsule may break due to high shear stress during the cooling process for recrystallization.

The moisturizing agent may be, but is not limited to, a polyol, which is preferably, but not limited to, butylene glycol, dipropylene glycol, propylene glycol, butylene glycol, dipropylene glycol, Propylene glycol, caprylyl glycol, disilene glycol, dipropylene glycol, ethylene glycol, hexylene glycol, polyethylene glycol, glycerin, diglycerin, ethylhexyl glycerin, polyglycerin, 1,6-hexanediol, 1,2-hexanediol, and 1,2-octanediol.

The present invention provides a method for preparing a cosmetic composition for skin moisturization of a transparent solubilized formulation containing macrocapsules in which ceramide is captured, comprising the steps of:

a) uniformly dispersing a water phase containing water, a moisturizing agent and a coupling agent in a vacuum emulsification tank, and then heating the mixture to 70 to 80;

b) Ceramide in another emulsion tank; Lipid complexes comprising cholesterol, fatty acids, higher alcohols and silicone elastomers; And oil, and then heating the mixture to 70 to 80;

c) cooling the water phase of step a) to 30-50;

d) injecting the oily phase of step b) into the vacuum emulsification vessel of step c), stirring and dispersing the oily phase; And

e) cooling the vacuum emulsifier of step d) to 20-50.

The ceramide, the lipid complex and the oil are recrystallized through the cooling process in the step e) to produce the capsules according to the present invention.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention, and it is to be understood by those skilled in the art that the present invention is not limited thereto It will be obvious.

< Example  >

Cosmetic compositions comprising macrocapsules in which ceramide was collected by using the recrystallization properties of ceramides, cholesterol, fatty acids and oils were prepared in the composition shown in Table 1 below.

The supernatant was added to the vacuum emulsification tank and uniformly dispersed and heated to 70 ~ 80. Also, the oil phase material was added to the emulsion tank separately from the water phase, uniformly dispersed, and heated to 75 to 80 ° C.

When the water phase is completely dissolved, the heated water phase is added to the cooled water and the paddle is stirred at a rotation speed of 15 to 30 rpm to uniformly disperse the water phase. The uniformly dispersed cosmetic was cooled to 32 to recrystallize ceramide, cholesterol, fatty acid and oil, neutralized and neutralized by adding a neutralizing agent, and defoamed in vacuo to complete a cosmetic composition.

Composition of cosmetic composition comprising ceramide macrocapsules division Component (% by weight) Example Comparative Example One 2 One 2 3 4 5 6 7 8 9 Water top water Balance Balance Balance Balance Balance Balance Balance Balance Balance Balance Balance Moisturizer 6.6 6.6 6.6 6.6 6.6 6.6 6.6 6.6 6.6 6.6 6.6 Incrementer 0.1 0.5 0.5 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Floating Ceramide 0.05 0.1 0.1 0.1 0.1 0.1 0.1 0.01 0.9 0.1 0.1 Lipid complex 1 0.15 0.2 - 0.05 6 0.15 0.15 0.15 0.15 0.15 0.15 Lipid complex 2 - - 0.2 - - - - - - - - oil 2 2 2 2 2 0.05 6 2 2 2 2 additive corrector 0.16 0.08 0.16 0.16 0.16 0.16 0.16 0.16 0.16 0.06 0.1 antiseptic Compound preservative 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 * Lipid composite 1: 2.5 parts by weight of cholesterol, 30 parts by weight of fatty acid, 5 parts by weight of higher alcohol, 10 parts by weight of silicone elastomer
Lipid complex 2: 2.5 parts by weight of cholesterol, 30 parts by weight of fatty acid, 5 parts by weight of higher alcohol
* Fatty acids: Stearic Acid
* Advanced Alcohol: Behenyl alcohol
* Silicone elastomer: dimethicone / vinyl dimethicone crosspolymer
* Oil: Cyclopentasiloxane, Dimethicone, Hydrogenated Polydecene
* Moisturizing agent: dipropylene glycol, butylene glycol
* Increasing agent: acrylate / C-10-30 alkyl acrylate crosspolymer

Experimental Example  One : Ceramide  Confirm the generation of macro capsules

A photograph of the cosmetic composition prepared in the composition of Example 1 is shown in FIG. In Fig. 1, ceramide can be identified as a macrocapsule which is captured and crystallized in a lipid complex 1 and a moisturizing oil. The mean diameter of the macrocapsules was measured as 100 to 1500.

Experimental Example  2: Formulation stability observation result

As a result of examining the formulations of the cosmetic compositions prepared according to the composition of Table 1, the ceramide macrocapsules were uniformly dispersed in Examples 1 and 2, and the capsules were uniformly dispersed for a long period of time even under severe conditions of 40 to 50. In Comparative Example 1, a part of ceramide was precipitated, the capsules were not uniform in size, microcapsules having a diameter of less than 80 were produced in a large amount, and some of the capsules were broken under the severe conditions.

In Comparative Example 2, the weight of the lipid composite relative to the weight of the ceramide was so small that the lipid complex could not sufficiently capture the ceramide, and the water phase and the oil phase were separated and the ceramide was precipitated. In addition, in Comparative Example 3, since the content of the lipid complex was excessively larger than the content of the ceramide, the recrystallized particles were aggregated with each other to form a large lump.

Further, in Comparative Example 4, the weight of the oil was so small that the ceramide macrocapsules were hardly formed, and the formed capsules were uneven in size and very large in deviation. In Comparative Example 5, the amount of the oil was excessive, so that the ceramide and oil were not properly trapped in the lipid composite during the recrystallization process, and the oil floated and floated, and the ceramides also leaked out of the capsule together with the oil.

The skin moisturizing effect in Comparative Example 6 was insignificant, and in Comparative Example 7, it was difficult to dissolve the ceramide because the ceramide content was excessive, and the ceramide aggregation phenomenon occurred.

In Comparative Example 8, the content of the carbomer neutralized in the entire cosmetic weight was so small that the viscosity was not formed properly, and thus, the recrystallization process was not properly performed, so that the ceramide macrocapsule could not be formed. In Comparative Example 9, the content of the neutralized carbomer was excessively high and the viscosity was too high, so that a high shear stress was applied during the cooling process for recrystallization, resulting in a problem that the ceramide macrocapsule was cracked.

Claims (10)

Wherein the lipid complex comprises cholesterol, fatty acids, higher alcohols and silicone elastomers; and a liposome complex and oil coated with ceramide.
The method according to claim 1,
Wherein the ceramide, the lipid complex and the oil are contained in a weight ratio of 1: 1 to 50:10 to 50, and the ceramide is captured in the oil.
The method according to claim 1,
Wherein the lipid complex comprises 0.01 to 5.0 parts by weight of cholesterol, 20 to 40 parts by weight of fatty acids, 1 to 10 parts by weight of a higher alcohol and 5 to 15 parts by weight of a silicone elastomer.
The method according to claim 1,
Wherein the macrocapsule has a diameter of 100 to 1500, and a lipid composite and a macrocapsule in which ceramide is captured in oil.
The method according to claim 1,
Wherein the oil is selected from the group consisting of dimethicone, lauryl dimethicone, cyclopentasiloxane, cyclohexasiloxane, trisiloxane, methyltrimethicone, phenylmethicone, dimethicone polyol, dimethicone polyol acetate, silicone glycol copolyol, Dimethicol , At least one silicone oil selected from the group consisting of methylpolysiloxane, methylphenylpolysiloxane, dimethicone polyol methyl ether, methylcyclopolysiloxane, dimethylpolysiloxane, hexamethyldisiloxane and caprylylmethylpolysiloxane; And at least one hydrocarbon oil selected from the group consisting of isododecane, isohexadecane, squalane, hydrogenated polyisobutene, vaseline, paraffin, ceresin, and mineral oil; And combinations thereof. &Lt; RTI ID = 0.0 &gt; 11. &lt; / RTI &gt;
The method according to claim 1,
The silicone elastomer may be selected from the group consisting of dimethicone / vinyl dimethicone crosspolymer, polysilicon-11, dimethicone crosspolymer, dimethicone / phage-10/15 crosspolymer, vinyl dimethicone / methicillosilsesquioxane crosspolymer, dimethicone / Polyglycerin-3 crosspolymer, diphenyl dimethicone / vinyl diphenyl dimethicone / silsesquioxane cross polymer, phage-10 dimethicone / vinyl dimethicone cross polymer, and lauryl dimethicone / polyglycerin- A lipid complex, and a macrocapsule in which ceramide is captured in an oil. The method according to claim 1,
The fatty acid may be selected from the group consisting of stearic acid, isostearic acid, oleic acid, palmitic acid, linoleic acid, lauric acid, undecanoic acid, neodecanoic acid, capric acid, caprylic acid, A lipid complex and one selected from the group consisting of an acid, an acid, a heptanolic acid, a myristic acid and a combination thereof.
The method according to claim 1,
Wherein the higher alcohol is one selected from the group consisting of lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, cetostearyl alcohol, and combinations thereof; a lipid complex and a macro capsule.
A cosmetic composition for skin moisturizing comprising the macrocapsule of claim 1.
a) uniformly dispersing a water phase containing water, a moisturizing agent and a coupling agent in a vacuum emulsification tank, and then heating the mixture to 70 to 80;
b) Ceramide in another emulsion tank; Lipid complexes comprising cholesterol, fatty acids, higher alcohols and silicone elastomers; And oil, and then heating the mixture to 70 to 80;
c) cooling the water phase of step a) to 30-50;
d) injecting the oily phase of step b) into the vacuum emulsification vessel of step c), stirring and dispersing the oily phase; And
e) a lipid complex comprising cholesterol, a fatty acid, a higher alcohol and a silicone elastomer, and a step of cooling the vacuum emulsion tank of step d) to 20 to 50, A method for producing a cosmetic composition for moisturizing skin of a solubilized formulation.

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