KR20170101791A - Functional Egg and Feed Additives for Producing the Same - Google Patents

Abstract

The present invention relates to functional eggs having effective components for preventing Alzheimers (dementia) and a feed additive for poultry for producing the same. According to the present invention, the feed additive comprises choline chloride and taurine. If the feed additive is consistently fed to laying hens over 15 days, choline chloride and taurine are concentrated in eggs produced by laying hens and the numerical values of choline and taurine in the eggs are increased. In addition, a user who takes in the eggs can take in choline and taurine through the eggs, thereby preventing cerebrovascular diseases such as Alzheimers (dementia).

Description

{Functional Egg and Feed Additives for Producing the Same}

The present invention relates to a functional egg having a component effective for preventing cerebrovascular diseases such as Alzheimer's (dementia) and Parkinson's disease, and feed additives for poultry for the production thereof.

Livestock industry is one of the most important economic activities that humanity has done since ancient times. The human food is largely divided into vegetable and animal. Here, the activity of producing vegetable food such as rice, barley and wheat is referred to as agriculture or raising agriculture and the production of animal food such as milk, meat and turtles is referred to as livestock farming . Conventionally, the process of simply producing livestock products has been classified as livestock, but recently, all processes including production, processing, and logistics of livestock products have been expanded and classified as livestock production.

Recently, with the development of livestock technology, studies on feeds for livestock products are actively under way. As a result of these studies, a variety of functional livestock products, which artificially regulate the composition of various ingredients contained in livestock products or enhance specific ingredients necessary for human beings to livestock products through the improvement of feeds for livestock products, have been developed and widely spread.

Among the functional livestock products, functional turbulence, especially functional eggs produced by chickens, is attracting much attention. Eggs are well known as the most complete nutritional food. Eggs are mainly composed of eggshells called egg shells and egg yolks called eggs yolks and egg whites. Moisture (74.7%), protein (12.3%), fat (11.2%) and minerals (0.9% , And other ingredients (0.9%). Vitelline, especially in the egg yolk, is effective in cell production and biosynthesis. Lecithin, especially choline in lecithin, is effective in brain activity and is effective in preventing Alzheimer (dementia) and improving blood circulation Taurine regulates beta amyloid, a substance responsible for Alzheimer's disease, and activates cognitive functioning brain glial cells. Lutein and zeaxanthin prevent aging-induced deterioration of vision, retinal protection, and cataracts And the like.

Mixing appropriate ingredients in the feed for livestock can adjust the composition of the meat obtained from the livestock. Especially for poultry such as chickens, ducks, and turkeys, the main components of the turbulence created by them Can be adjusted. For example, in WO 2009/014497 (Use of Cordyceps species or extract in the egg production), cordycepin extracted from, for example, Millitarian Cordyceps, is fed to chickens and the amount of cholesterol Quot; is lowered. In addition, Patent Publication No. 10-2007-0025342 (Functional Egg to Help Promote Insulin Secretion and Its Production Method), Patent Registration No. 100537368 (Feed for Functional Egg Scattering, Drinking Water, Functional Egg Produced by Feeding the Functional Eggs and Their Production Method) (100%), and a variety of functional eggs such as 100835885 (health-functional eggs that increase the high-density cholesterol content), as well as omega-3 fatty acids and CLA (Conjugated Linoleic Acid) fortified eggs, vitamin fortified eggs, carotenoids, and fortified eggs have been developed and popularized.

The main object of the present invention is to provide a feed additive capable of producing a functional egg having an extremely effective effect for prevention of Alzheimer's disease (dementia) and a functional egg produced through the feed additive to the feed fed to poultry.

It is another object of the present invention to provide a feed additive which is added to feed for poultry to minimize the use of antibiotics against poultry by enhancing the immunity of poultry.

The feed additive according to the first aspect of the present invention for realizing the above object is a feed additive added to a feed for laying poultry, the feed additive comprising choline chloride and weathered cyanophyllum powder, And a control unit.

The feed additive may further comprise taurine.

The feed additive is further characterized by comprising pig blood.

The feed additive is further characterized by comprising a Cordyceps sinensis extract and? -Glucan.

The feed additive may further include Bacillus subtilis.

Further, the feed additive is characterized in that the feed additive further comprises a benefit agent.

The functional egg according to the second aspect of the present invention is characterized in that the functional egg is produced by feeding the feed additive to a laying hens.

When the feed additive according to the present invention is continuously fed to the laying hens for preferably 15 days or more, choline and taurine are concentrated in the eggs produced by the laying hens, thereby increasing the levels of choline and taurine in the eggs. And those who consume these eggs will be able to consume choline and taurine through the egg, so they can enjoy the effective effect of preventing cerebral vascularization such as Alzheimer's.

Hereinafter, embodiments according to the present invention will be described. It should be understood, however, that the embodiments described below are illustrative of one preferred embodiment of the present invention, and the examples of such embodiments are not intended to limit the scope of the present invention. The present invention can be variously modified without departing from the technical idea thereof.

Choline, taurine and carnosine have attracted attention as effective ingredients for Alzheimer's. Here, choline and taurine are contained in egg yolks. As described above, choline is effective for preventing and treating Alzheimer's disease and improving blood circulation by decomposing fat and improving brain function. Taurine regulates beta amyloid, a substance causing Alzheimer's disease, and activates cognitive functioning brain glial cells Is known to provide. We can get the effect of preventing Alzheimer's by eating the eggs continuously.

A derivative of histidine, canosin, is produced from histidine and alanine in the metabolic process of an animal. It exhibits the anti-aging effect and the neuroprotective effect to reduce the stroke mortality, and in particular, the brain such as Alzheimer's disease and Parkinson's disease Has been attracting attention as being effective in the prevention of blood vessel quality.

Studies have shown that histidine and alanine are relatively abundant in pig blood (5.80% and 6.80%, respectively) in animal blood. Table 1 below shows the amino acid analysis results of pig blood.

ingredient content(%) Aspartic acid 10.32 Threonine 3.47 Serine 4.49 Glutamic acid 8.48 Proline 2.96 Glycine 4.08 Alanine 6.80 Balin 6.15 Isoleucine 0.77 Leucine 11.38 Tyrosine 1.87 Phenylalanine 5.80 Histidine 5.80 Lysine 7.73 Arginine 3.95 Cystine 1.41 Methionine 0.68

Considering the above considerations, Patent Registration No. 10-1070236 (titled "Method for enhancing caninoin content in chicken tissue") by adding a blood meal of an animal to a broiler feed to prepare carnosine ) Is increased.

However, according to the study of the present inventors, it has been confirmed that the amount of cannosine produced in the body of the laying hens is very small in the transition to egg accumulation. In order to produce an effective egg for Alzheimer's, it would be desirable to strengthen the choline and taurine contained in the yolk of the egg.

The feed additive according to the first embodiment of the present invention includes choline chloride. Wherein the choline chloride is included in the feed in an amount of about 0.1-0.3 wt%. Also, choline chloride is preferably in the form of a granule in which 60% by weight of choline chloride is adsorbed on an excipient such as corn powder.

In a second embodiment of the present invention, the feed additive comprises taurine. Taurine can preferably be employed with choline chloride. Taurine, like choline chloride, is approximately 0.1 to 0.3% by weight based on the feed.

In another embodiment, the feed additive may include a liver function improving agent such as vitamin C or vitamin E. The liver function improver activates the liver function of the laying hens and improves the transfer rate of choline or taurine to egg yolk.

The feed additive may preferably contain pig blood. Pork blood contains various vitamins and minerals in addition to amino acids such as histidine and alanine described above.

Table 2 below shows the results of mineral and vitamin analysis in pig blood.

ingredient unit Content per Kg General component building % 92.0 Crude protein % 87.6 Crude fat % 1.6 vitamin Vitamin E mg 1.0 Biotin mg 0.08 Choline mg 781 Folic acid mg 0.10 Niacin mg 23 Pantothensin mg 1.0 Riboflavin mg 1.4 Thiamine mg 1.0 Vitamin B6 mg 4.4 Vitamin B12 G 44 Minerals calcium % 0.21 sign % 0.21 Goat % 0.38 magnesium % 0.21 potassium % 0.14 salt % 0.29 sulfur % 0.45 Copper mg 6 iron mg 2,341 manganese mg 10 zinc mg 16

As can be seen in Table 2, the pig's blood contains a large amount of choline and iron in particular. The pig's blood content is about 0.8% by weight in the feed. The addition of pig blood to feed for laying hens results in a high choline and iron content in eggs. Iron is effective for preventing anemia in children and women as well known.

The feed additive according to the present invention is particularly preferably applied to laying hens. If the feed additives according to the present invention are continuously fed to the laying hens for preferably more than 15 days, choline and taurine are concentrated in the eggs produced by the laying hens and the choline and taurine levels in the eggs are increased. Users who consume these eggs will be able to consume choline and taurine through the eggs, so they can enjoy the effective effect of preventing cerebrovascular diseases such as Alzheimer's (dementia).

On the other hand, animal feed such as blood or feather meal is very effective in providing proteins useful for broiler or laying hens, while there is a concern that broiler or laying hens may be exposed to diseases by feeding animal feed, It is required to ensure more reliable stability.

The most effective way to protect livestock, including broilers and laying hens, from the risk of disease is to administer or feed antibiotics to the livestock. However, this method causes a negative problem that the antibiotics fed to the poultry accumulate in the turbulence produced from the poultry and ultimately be absorbed into the human body. The preferred way to protect livestock from disease is to increase the immunity of the livestock so that the livestock is not infected with the disease. However, the enhancement of immunity of livestock is difficult to implement in a simple way and requires much research.

According to the results of a lot of research conducted by the present inventor, it was confirmed that Cordyceps sinensis and [beta] -glucan are very effective for increasing the facial strain of animals, and in particular, when these components are used in combination, a greater synergistic effect is exhibited.

1. Cordyceps

Cordyceps is a type of mushroom named in the form of insects that enter the body of insects during winter and absorb insects to kill insects and make grass-shaped mushrooms from dead insects when it is summer. Typhoong mushroom strains belong to the genus Ascomycota, Pyrenomycetes, Clavicipitaceae and Codyceps. They belong to 300 species of 100 genera, including Korea, China and Japan. It is known.

Currently, edible cordyceps are three kinds: Poecilomyces japonico, Cordyceps militaris, and Cordyceps sinensis. Among them, it is a kind of entomopathogenic fungi which forms larval stem of orange color with larva or pupa of Lepidoptera as a host, and it is more effective than cordycepin It contains a large amount.

In the present invention, as a feed additive, in addition to the above swine blood, cordyceps, preferably Millitarian Cordyceps, is used.

For example, the Cordyceps sinensis extract may be obtained by pulverizing, for example, Millitaris caterpillar fungus to a size of about 180 to 200 meshes to form a pulverized material, mixing the pulverized material with water, heating the mixture at a temperature of 100 to 140 degrees for 2-4 hours And heating.

Table 1 below shows useful components and functions of the Cordyceps mellifera extract produced through the above process.

Useful ingredient function Codisepin
(Cordycepin) Natural antibiotics, immunostimulants Codisepic acid
(Cordycepic acid) Prevention and treatment of vasodilators, cerebral thrombosis, renal vasectomy Codispeptide polysaccharide
(Cordycepic polysaccharides) Improving immunity and improving heart and liver, inhibiting cancer and preventing aging SOD
(Superoxide Dismutase) Prevention of aging and cancer and adult diseases by active enzymes
vitamin
VA Maintain normal function of skin tissue VP Metabolic activity VB12 Brain relationship, intelligence - Nutrients, Improved movement of nerves, Soy protection
microelement
Seren Cancer prevention and anti-aging zinc Cell growth and growth Copper Cell and skin regeneration

The feeding of the Chinese cabbage extract to livestock is carried out in the form of liquid or granular (powder). The liquid form of the Cordyceps cristatus extract is mixed with the feed water for livestock at a ratio of 1/1000 to 1/3000, preferably 1/2000. As the liquid insecticide extract, 10% by weight or more of cordycepin is preferably used. In addition, the granular form of Cordyceps sinensis extract is added to the livestock feed, which is then mixed with 1 kg / l of feed 1 M / T. Of course, the addition ratio of the Cordyceps sinensis extract to the feed is not limited to a specific value but can be appropriately adjusted. In addition, the granular form of the Cordyceps sinensis extract is prepared by a method of adsorbing 10% by weight of a liquid form of Cordyceps sinensis extract, for example, in dextrin.

The Cordyceps sinensis extract greatly activates the immune system of livestock and greatly enhances resistance to various diseases. In particular, the extracts of Cordyceps sinensis were fed to poultry such as chickens. It has been shown to improve resistance to H5N1, Newcastle disease and Marek's disease and to have a significant effect on the prevention of coccidiosis and chicken infectious bronchitis.

It was also found that the content of inosine (IMP) in chickens was increased by feeding the Chinese cabbage extract to broiler chickens. That is, the IMP of the chicken fed with Cordyceps was 2.31 ~ 2.41 mg / g, whereas the IMP of the control group without the Cordyceps was 1.61 mg / g. IMP is a nucleic acid material that enhances the meat's richness, and the amount of IMP is known to have a significant association with meat taste.

Especially, when cod liver oil extract was fed to the laying hens, about 1.0 mg of codisepin was accumulated in the eggs. As described above, cordycepin is a natural antibiotic and immunostimulating substance. Codisepin, which has accumulated eggs, not only increases the circulation period of eggs, but also enhances the immunity of the users who ingest them.

2. β-Glucan

β-glucan was first discovered to participate in a nonspecific immune response on the yeast cell wall. Widely known is β-1,3 glucan in which glucose is composed of β-1,3 bonds. β-Glucan is a member of the cereal epidermis such as barley, oat, rye and the cell wall of S. cerevisiae, mycelium and fruiting body such as mushroom, cloud mushroom, myrtle, and agaricus mushroom, and bacteria of Agrobacterium Cells and polysaccharides.

The feed of the beta -glucan to the livestock is carried out in the form of liquid or granular (powder) like the above-mentioned Cordyceps extract. As the liquid β-glucan, for example, a 3% concentrate of β-glucan is used, and the livestock is mixed with the negative numbers for livestock in a ratio of 1/1000 to 1/3000, preferably 1/2000. In addition, the granular β-glucan is added to livestock feed, and the addition ratio is carried out by mixing 1 kg of feed 1 M / T, for example. Of course, the feed amount of? -Glucan to the livestock can be appropriately adjusted. Here, the granular? -Glucan is produced through a method of adsorbing? -Glucan concentrate, for example, at 5 wt% in soybean meal.

β-glucan promotes the secretion of cytokines, a physiologically active substance secreted by leukocytes, thereby enhancing the immunity of livestock, and enhancing anti-tumor, anti-bacterial and antiviral activity by activating nonspecific immune cells. In particular, when β-glucan is fed to the laying hens, β-glucan inhibits the calcium mobilization of the bones, thereby contributing to a supplementary effect of improving egg shell strength by helping supply of calcium that can be used for forming egg shells in the body.

The feed additive for livestock according to this embodiment is provided in a liquid or granular form. The liquid feed additive comprises a Cordyceps sinensis extract, preferably a liquid insecticidal extract containing 10% by weight of cordycepin and a liquid β-glucan. They are administered to the livestock provided negative water. The feed amount of the liquid insecticide extract and the liquid beta -glucan to the livestock is set to be approximately 1/1000 to 1/3000 of the negative number.

In addition, the feed additives of the granule include a granular form of Cordyceps sinensis extract and granular β-glucan. They are mixed with livestock feed and fed to livestock. The feed amount for the livestock of the granular feed additive is set to approximately 0.1% by weight of the feed amount.

In another embodiment of the present invention, the granular feed additive further comprises Bacillus subtilis powder. At this time, the amount of Bacillus subtilis is set to about 10 ⁸ cfu / g, for example. Bacillus subtilis bacteria has been studied to be very effective for blood pressure, diabetes, blood circulation improvement, thrombolysis, osteoporosis, diet, and key growth. When fed to livestock, it is located in the duodenum and produces natural antibiotics and antibiotics, It is confirmed that it can improve disease prevention and immunity.

Further, in another embodiment of the present invention, fungicide or biotite powder weathered in addition to pig blood is included. The feed amount of weathered celadon rock (biotite) is set to about 2 kg, for example, about 1 M / T for feed. Weathered phyllite, including various minerals, not only meets the trace elements required for the growth of livestock, but also effectively enhances the immunity of the livestock.

Table 2 shows the results of analysis of the weathered ctenoid rocks, which is a result of analysis of ctenoid rocks collected from the Quangryeam mine located at 226-3, Hwanghae-ri, Suan-myeon, Bo-eun, Chungcheongbuk-do.

SiO ₂ Al ₂ O ₃ Fe ₂ O ₃ MgO K ₂ O Ca S Ti 65.9% 10.2% 5.25% 5.58% 1.22% 2.2% 0.06% 0.6% Se Ge Mn P B V Sr Z 1.06 ppm 2.3 ppm 733 ppm 540ppm 338 ppm 88.8 ppm 62 ppm 60.7 ppm  CEC (base displacement capacity 34 mep / 100 g), organic matter 3.6%

Particularly, the weathered cryptomeria contains at least 8.3 x 10 ⁸ cfu / g of Streptomyces belonging to the Actinomyces family. These actinomycetes produce a wide variety of natural antibiotics, thereby enhancing the immunity of livestock.

In the livestock feed additive according to the present invention, the Cordyceps sinensis extract, β-glucan, Bacillus subtilis, and actinomycetes both increase the immunity of domestic animals and prevent diseases. Therefore, feeding these feed additives with choline chloride and taurine to the laying hens can lower the risk of livestock farmers by using animal feeds, and can greatly reduce the use of antibiotics for laying hens by increasing the immunity of the laying hens. As well as minimizing the exposure of the laying hens to disease.

In addition, when the feed additive according to the present invention is continuously fed to the laying hens for 15 days or longer, the beneficial ingredients of the Chinese cabbage extract and the human body contained in? -Glucan in addition to choline chloride and taurine are concentrated in eggs produced by the laying hens do. Cordyceps is effective in improving liver function and hangover, improving blood sugar and blood circulation, anticancer effect, immunity increasing and anti-inflammatory effect, nourishing tonic effect, whitening effect, sexual function improving effect, brain and cardiovascular disease prevention effect, Dissolution effect, and obesity improvement effect. In addition, β-glucan has been shown to be effective in humans in terms of immune strengthening effect, blood pressure and blood sugar enhancing effect, skin regeneration and protection effect, harmful active oxygen elimination effect, anticancer effect, memory recovery effect, cancer prevention effect through lymphocyte activation, And the like.

therefore. When the above-mentioned egg is consumed by a human, it is possible to take various functional ingredients together with the complete nutrient intrinsic to the egg, so that the egg can be effectively utilized as an effective health supplement for human.

In addition, the feed additive according to the present invention lowers the level of low density cholesterol (LDL) contained in the eggs when fed to the laying hens, and improves the eggshell strength of eggs, as well as enhances the antibacterial function of eggs, An additional effect of increasing the period can be obtained.

The embodiments according to the present invention have been described above. However, the present invention is not limited to the above-described embodiments, and various modifications may be made without departing from the technical spirit of the present invention.

For example, a dried red crap shell may be preferably included in the feed additive. Crude protein contains approximately phosphorus (more than 1.8%), crude protein (more than 23.0%), calcium (more than 10.3%), moisture (less than 13.0%) and inquiry (less than 50.0%). Adding eggplant to the diet enhances the color of egg shells, increases flavor, improves freshness, and increases the shelf life of eggs. Especially, crab improves taurine content of eggs. The crab is preferably included at about 0.5% by weight relative to the feed.

Astaxanthin, a carotinoid coloring agent in crabs, accumulates in eggs, which helps prevent skin aging, improve vision, reduce allergic reactions due to immunity enhancement, inhibit cancer cell growth, regulate blood sugar and normalize blood lipid levels And provides a beneficial effect that sharpens egg yolks and yolk color.

Claims (6)

A feed additive to be added to a feed for laying poultry,
Comprising choline chloride or taurine and weathered celestial powder,
Wherein the weathered cedar foliage comprises actinomycetes. The method according to claim 1,
≪ / RTI > wherein the composition further comprises pig blood. The method according to claim 1,
A feed additive characterized by further comprising a Cordyceps sinensis extract and? -Glucan. The method according to claim 1,
A feed additive characterized by further comprising Bacillus subtilis. The method according to claim 1,
≪ / RTI > wherein the feed additive further comprises an additive. A functional egg produced by feeding the feed additive of any one of claims 1 to 5 to a laying hens.