KR20170099607A - Reacting kit for blood coagulation test - Google Patents
Reacting kit for blood coagulation test Download PDFInfo
- Publication number
- KR20170099607A KR20170099607A KR1020160021923A KR20160021923A KR20170099607A KR 20170099607 A KR20170099607 A KR 20170099607A KR 1020160021923 A KR1020160021923 A KR 1020160021923A KR 20160021923 A KR20160021923 A KR 20160021923A KR 20170099607 A KR20170099607 A KR 20170099607A
- Authority
- KR
- South Korea
- Prior art keywords
- reagent
- unit
- tray unit
- reaction
- blood coagulation
- Prior art date
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0429—Sample carriers adapted for special purposes
- G01N2035/0436—Sample carriers adapted for special purposes with pre-packaged reagents, i.e. test-packs
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0443—Rotary sample carriers, i.e. carousels for reagents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0474—Details of actuating means for conveyors or pipettes
- G01N2035/0491—Position sensing, encoding; closed-loop control
Abstract
The sequential reaction type blood coagulation test kit of the present invention comprises a plurality of reagent packages filled with reagents, a reaction part formed as a groove with an opening at the center thereof, a plurality of reagent injection parts And a main body including a pressing member for pressing the reagent package, wherein the rotating plate is provided with a rotation unit for periodically rotating the tray unit, And the pressurizing body sequentially pressurizes the reagent package accommodated in the reagent input portion and injects the reagent into the reaction portion.
Description
The present invention relates to a kit for examining a blood coagulation reaction, and more particularly, to a kit for testing blood coagulation state by measuring the amount of prothrombin in the blood by sequentially reacting blood for sample with another reagent .
Generally, when the blood is exposed to the outside, platelets in the blood are destroyed to produce thromboplastin, which acts together with calcium ions in the blood to convert prothrombin, which is one of plasma proteins, into thrombin.
This thrombin acts on fibrinogen, entangled in a net shape, and with blood cells in it, the fibrin becomes smaller and coagulated as time passes.
Coagulation of blood is an essential function to maintain life. If blood does not coagulate during hemorrhage, it will lead to excessive hemorrhage. On the other hand, if blood coagulates in the body, blood circulation will be inhibited.
The various anticoagulants present in the blood or endothelial cells prevent the blood from clotting in the blood vessels, and the deficiency of these anticoagulants causes thrombosis due to the clotting of blood vessels in the blood vessels.
Therefore, blood coagulation tests for measuring whether blood coagulates or inhibit coagulation within a normal range have been performed variously.
There are methods to measure bleeding time (BT), which is the time until bleeding stops, and to measure the prothrombin time (PT), which is the time to coagulate by reacting certain reagents to the blood. However, There was a limit to collecting data on blood clotting.
Therefore, a method for solving such problems is required.
Disclosure of the Invention The present invention has been conceived to solve the above problems of the prior art, and it is an object of the present invention to provide a method for detecting Ⅱa which can rapidly and accurately quantitively detect Ⅱa which is a blood coagulation factor indicating thrombin as an active form of prothrombin in blood The present invention provides a test kit for measuring the reaction result by sequentially injecting a sample into a blood sample in consideration of the reaction time of the reagents.
The problems of the present invention are not limited to the above-mentioned problems, and other problems not mentioned can be clearly understood by those skilled in the art from the following description.
In order to accomplish the above object, the sequential reaction type blood coagulation test kit of the present invention comprises a plurality of reagent packages filled with reagents, a reaction part formed as a groove opening upward at the center and a reagent package, And a main body including a pressing member for pressing the reagent package, wherein the tray unit is provided with a tray unit having a plurality of reagent injecting units to be connected and a loading port through which a tray unit is inserted, The tray unit is periodically rotated, and the pressurizing body sequentially pressurizes the reagent package accommodated in the reagent input unit and injects the reagent into the reaction unit.
The tray unit is formed in a disc shape having a predetermined thickness and is provided with a plurality of reagent injection parts at radial positions with respect to the reaction part, and the reagent injection part is formed adjacent to the side surface.
Alternatively, the tray unit includes an opening which is opened to penetrate the reagent charging part on the side surface and is provided so that the pressing body can enter the inside of the reagent charging part.
The flow tube includes a protruding portion protruding from an inner space of the reagent input portion, and the protruding portion breaks one side of the reagent package as the pressurizing body enters the opening and presses the reagent package.
Alternatively, the flow tube may include a tubular body inserted in the longitudinal direction inwardly, a channel formed in the inner side thereof, and a sharp tip at one end thereof, the tray unit being formed of an elastic body, the tip of the tubular body being disposed toward the reagent charging portion, As the sieve presses one side of the tray unit, the tip protrudes into the inner space of the reagent injecting unit to crush the reagent package.
A guide rail is formed on the upper surface of the rotary plate so as to protrude by at least one or more lengths. The lower surface of the tray unit is provided with a guide groove recessed in a shape corresponding to the guide rail. Transfer torque to the tray unit.
Alternatively, the main body includes a sensor provided to measure the hue or brightness of the reaction part.
The main body includes a display unit for displaying a value measured by the sensor.
Alternatively, the main body controls the angle at which the rotating body rotates and the time at which the rotating operation is stopped by the predetermined data, and controls the pressing body to press the reagent package through the reciprocating motion in the state where the rotating operation of the rotating body is stopped Module.
In order to solve the above problems, the sequential reaction type blood coagulation test kit of the present invention is a kit for detecting blood coagulation factor IIa present in a blood sample in a rapid and accurate manner, A reagent such as a hydrogen peroxide solution and an ODI solution is injected so as to sequentially react with a blood sample in consideration of each reaction time, thereby improving the accuracy and promptness of the blood coagulation test, and the color or brightness It is possible to obtain an effect of detecting and quantitatively displaying the information.
The effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned can be clearly understood by those skilled in the art from the description of the claims.
1 is a perspective view of a sequential reaction type blood coagulation test kit according to an embodiment of the present invention.
FIG. 2 is a schematic cross-sectional view showing a main body of a sequential reaction type blood coagulation test kit according to an embodiment of the present invention.
3 is a perspective view and a partial cross-sectional view illustrating a tray unit of a sequential reaction type blood coagulation test kit according to an embodiment of the present invention.
FIG. 4 is a diagram illustrating a process of sequentially introducing a reagent into a reaction part from a reagent package of a sequential reaction type blood coagulation test kit according to an embodiment of the present invention.
5 is a cross-sectional view of a tray unit of a sequential reaction type blood coagulation test kit according to another embodiment of the present invention.
FIG. 6 is a state diagram showing a state in which a tray unit of a sequential reaction type blood coagulation test kit receives an external force from a pressurizing member and the reagent package is broken. FIG.
7 is a plan view showing a tray unit of a sequential reaction type blood coagulation test kit according to another embodiment of the present invention.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings. In describing the present embodiment, the same designations and the same reference numerals are used for the same components, and further description thereof will be omitted.
The sequential reaction type blood coagulation test kit according to the present invention can be carried out as follows.
FIG. 1 is a perspective view of a sequential reaction type blood coagulation test kit according to an embodiment of the present invention, FIG. 2 is a schematic cross-sectional view showing a main body of a sequential reaction type blood coagulation test kit according to an embodiment of the present invention, FIG. 4 is a perspective view of a reagent package of a sequential reaction type blood coagulation test kit according to an embodiment of the present invention. FIG. 4 is a cross-sectional view of a reagent package of a sequential reaction type blood coagulation test kit according to an embodiment of the present invention. FIG. 2 is a view showing the process of sequentially injecting the reaction solution into the reaction part. FIG.
1 to 4, the construction of a sequential reaction type blood coagulation test kit according to an embodiment of the present invention includes a plurality of
Each of the above-described configurations will be described in detail below.
The
The
A space for accommodating the
The
2, at least one
2, the
The
This is an exemplary embodiment, and the
The
The sensor 140 may be a chemiluminescence sensor capable of measuring light emission caused by a chemical reaction or a chemiluminescence sensor capable of measuring colors generated in response to a chemical reaction so that the reagent and the blood sample The change in color or brightness generated through the reaction is measured.
1, the
The
The double plum solution, the hemine solution, the Amplex red solution, the hydrogen peroxide solution and the ODI solution can be realized by storing various reagents in the
As shown in FIG. 3, the
The
The reagent injecting
This is because the
The
Each of the
3, the
The
At this time, the
A
The
The
In addition, there is an effect that the
Each of the reagent packages 300 is accommodated in a plurality of
The
A, b, c, d, e (e) stored in the respective
FIG. 5 is a cross-sectional view of a tray unit of a sequential reaction type blood coagulation test kit according to another embodiment of the present invention, FIG. 6 is a cross- FIG. 7 is a plan view showing a tray unit of a sequential reaction type blood coagulation test kit according to another embodiment of the present invention. FIG. 7 is a plan view showing a tray unit of a blood coagulation test kit according to another embodiment of the present invention.
Referring to Figures 5-7, the
5 and 6, the
The
One end of the
The
The
The
The
Each of the reagent packages 300 is filled with the double pressure thermometer solution, hemine solution, Amplex red solution, hydrogen peroxide solution, and ODI solution, and the blood coagulation reaction is checked in order to check the blood coagulation reaction. And the
In the embodiment of the present invention, the
The operation of the sequential reaction type blood coagulation test kit according to one embodiment of the present invention will be described based on the above structure.
A blood sample as a sample to be inspected is injected through the open upper part of the
The
Each
The blood sample of the
It will be apparent to those skilled in the art that the present invention can be embodied in other specific forms without departing from the spirit or scope of the invention as defined in the appended claims. It is obvious to them. Therefore, the above-described embodiments are to be considered as illustrative rather than restrictive, and the present invention is not limited to the above description, but may be modified within the scope of the appended claims and equivalents thereof.
100: main body 110: inlet
120: rotation plate 122: guide rail
130: pressure body 140: sensor
150: Control module 160:
200: tray unit 210:
220: reagent injecting section 230: flow tube
232: acute portion 240: tubular body
242: leading edge 244: fixed end
250: opening 260: guide groove
300: Reagent package
Claims (9)
A reaction unit formed in a groove with an opening at the center thereof, and a plurality of reagent injection units accommodated in the reagent package and connected to the reaction unit through a flow pipe; And
And a main body including a pressing member for pressing the reagent package, the main unit including a rotating plate for rotating the tray unit,
Wherein the rotating plate periodically rotates the tray unit and the pressing body sequentially pressurizes the reagent package accommodated in the reagent injecting unit and injects the reagent package into the reaction unit.
The tray unit includes:
Wherein the reagent injecting unit is formed in a disc shape having a predetermined thickness and has a plurality of reagent injecting units at radial positions with respect to the reaction unit, and the reagent injecting unit is formed adjacent to the side surface.
The tray unit includes:
An opening portion that is opened to penetrate the reagent injecting portion on the side surface and is capable of allowing the pressing body to enter the inside of the reagent injecting portion;
A blood coagulation test kit.
The flow tube may include:
And an acute portion protruding from an inner space of the reagent injecting portion,
Wherein the pointing unit breaks one side of the reagent package as the pressure body enters the opening and presses the reagent package.
The flow tube may include:
And a tubular body inserted into the tubular body in the longitudinal direction and having a flow path formed on the inner side thereof and having a sharp tip at one end thereof,
Wherein the tray unit is formed of an elastic body and the tip of the tubular body is disposed toward the reagent injecting part so that the tip protrudes into the inner space of the reagent injecting part as the pressing body presses one side of the tray unit, A sequential reaction type blood coagulation test kit.
The rotary plate is provided with a guide rail protruding from the upper surface of the tray unit at least one long, and a guide groove formed in a lower surface of the tray unit in a shape corresponding to the guide rail is provided, And the rotational force of the rotating plate is transmitted to the tray unit.
The main body includes:
A sensor provided to measure color or brightness of the reaction part;
A blood coagulation test kit.
The main body includes:
A display unit for displaying a value measured by the sensor;
A blood coagulation test kit.
The main body includes:
A control for controlling the angle at which the rotating body rotates and the time at which the rotating operation is stopped by the preset data and controls the pressing body to press the reagent package through the reciprocating motion in a state where the rotating operation of the rotating body is stopped, module;
A blood coagulation test kit.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020160021923A KR101844748B1 (en) | 2016-02-24 | 2016-02-24 | Reacting kit for blood coagulation test |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020160021923A KR101844748B1 (en) | 2016-02-24 | 2016-02-24 | Reacting kit for blood coagulation test |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20170099607A true KR20170099607A (en) | 2017-09-01 |
KR101844748B1 KR101844748B1 (en) | 2018-05-18 |
Family
ID=59923701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020160021923A KR101844748B1 (en) | 2016-02-24 | 2016-02-24 | Reacting kit for blood coagulation test |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR101844748B1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020228335A1 (en) * | 2019-05-14 | 2020-11-19 | 深圳市亚辉龙生物科技股份有限公司 | Light avoidance structure for detecting optical signal |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006122041A (en) * | 2004-10-01 | 2006-05-18 | Hitachi High-Technologies Corp | Chemical analyzer |
-
2016
- 2016-02-24 KR KR1020160021923A patent/KR101844748B1/en active IP Right Grant
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020228335A1 (en) * | 2019-05-14 | 2020-11-19 | 深圳市亚辉龙生物科技股份有限公司 | Light avoidance structure for detecting optical signal |
Also Published As
Publication number | Publication date |
---|---|
KR101844748B1 (en) | 2018-05-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6770107B2 (en) | system | |
DK2615454T3 (en) | Cartridge device for a measuring system for measuring the viscoelastic characteristics of a sample liquid and its method | |
JP3392871B2 (en) | Apparatus for analyzing viscosity change of fluid sample and analysis method thereof | |
US20130333448A1 (en) | Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method | |
US11691142B2 (en) | Autoplatelet cartridge device | |
US11644476B2 (en) | Analysis device | |
JP2004512501A (en) | Gimbal capsule actuator for use with test specimens | |
JP2008544265A5 (en) | ||
JP6626203B2 (en) | Blood test system and method | |
US11768210B2 (en) | Portable coagulation monitoring devices, systems, and methods | |
KR101844748B1 (en) | Reacting kit for blood coagulation test | |
US10031146B2 (en) | Sample analysis device | |
US20210268497A1 (en) | Microfluidic thromboelastometry instrument | |
KR101790953B1 (en) | Airborne reagent type kit for blood coagulation test | |
CN113906295A (en) | Coagulation test devices, systems, and methods of use | |
CA2928954C (en) | Portable coagulation monitoring devices, systems, and methods | |
US11467175B2 (en) | Analysis device and positioning method | |
US20240069043A1 (en) | Portable coagulation monitoring devices, systems, and methods | |
US20240003920A1 (en) | Portable coagulation monitoring devices, systems, and methods | |
CN219915635U (en) | Blood sampling detects integrative kit | |
KR102076524B1 (en) | Test apparatus of fluidic sample and test method of fluidic sample | |
WO2017096287A1 (en) | Blood testing system and method | |
WO2017096278A1 (en) | Blood testing system and method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right |