KR20170088674A - Analyszer of human body component and analysis method thereof - Google Patents

Abstract

The BIA method is a method of obtaining resistance, reactance, and impedance obtained by flowing alternating current of a certain frequency to a human body. Among the properties that interfere with the current flow obtained by the BIA method, the quantity of human body constituents of quantitative body water, fat, and fat can be obtained by using a regression equation using the impedance as the body water. In other words, the BIA method has a principle that can explain not only the indirect process of obtaining the impedance as the body water by the regression equation but also the human body configuration according to the direct values of resistance, reactance, and impedance itself. Therefore, the resistance directly obtained by the BIA method can provide information on the quantitative component of the body water and the size of the human body, and the reactance is a function of the cell mass and the structural integrity of the cell in the human body, And the like. The phase angle, which represents the relationship between the two, is expected to provide information that can be used to diagnose, assess, and track the prognosis of the body's constituent, nutritional status, and disease.

Description

TECHNICAL FIELD [0001] The present invention relates to a human body component analyzing apparatus,

And a method of analyzing the human body component. More particularly, the present invention relates to an apparatus and a method for analyzing and evaluating the state of components constituting the human body using a bioelectrical impedance (BIA) method.

The constituent of the human body can be divided into fat, body water, protein, and mineral. According to the combination of these four components, the differentiation models of the human body are divided into fat and body fat, and fat, body water, and residual amount, which is a three-dimensional model. When the components of the human body are maintained at a constant ratio and are in harmony with each other, the homeostasis is maintained and the human body functions smoothly. Therefore, it is an important means for evaluating the function of the human body to obtain the composition ratio of the human body components. Conventionally, methods such as the underwater weight method, the double method, the DXA method, and the BIA method have been used. Among the methods of evaluating these human body configurations, the most practical, stable, and convenient method of application is the BIA method (Heymsfield, Lohman, Wang, & Going, 2005: Wang, Pierson.

In 1940, Barnett first reported that changes in clinical water status due to disease were related to the resistance and reactance of the human body. In the same year, Nyboer et al. (1940) reported that changes in blood flow to the organs and pulse waveforms of the arteries were related to changes in the impedance of the human body (Nyboer, Banget, & Halsey, 1940) Many researchers have used impedance blood plethysmography to demonstrate changes in blood impedance due to changes in blood flow (Nyoer, 1970: Thomasett, 1962), while changes in blood flow in the arms, legs, and other organs have been demonstrated using Impedance plethysmography .

Thomasett in 1962 and Hoffer in 1969 reported the relationship between body impedance and total body water (TBW), and demonstrated the possibility of body composition and body composition analysis using impedance. However, studies on the analysis of body water by impedance have played a decisive role in the first generation of the BIA analyzer, which has been widely used since 1983 when Nyboer measured human impedance by impedance measurement. At this time, with the help of Nyboer, the BIA analyzer was first commercialized and used by the public. The analysis method was a 50 kHz single body frequency analysis (Whole Body Single Frequency Bioimpedance Analyzer) method. This method is a method that obtains the impedance value of the human body by sending a short frequency of 50kHz by attaching an electrode to the hands and feet while the subject is lying down for examination and is a universally universal model to date. In 1989, Patterson reported that the segmental bioimpedance was sensitive to changes in body composition, and then the whole Body Impedance method and the Segmental Body In 1994, Chumlea and Guo analyzed the balance and change of internal fluid and inner fluid in clinical studies by analyzing human impedance using multi-frequency, and multi-frequency human impedance studies were performed together There is. Currently, the BIA method, which is widely used worldwide, is a single-frequency human impedance method with a frequency of 50 kHz. Currently, studies on validity of segmented human impedance analysis and multifrequency human impedance analysis are underway. In Korea, studies on the BIA method have been actively carried out since the early 1990s. As of 2007, multiphase segment impedance analysis has been developed and the most evolved model in the world has been developed to measure the intracellular moisture, extracellular water, fat , And fat.

A human body component analyzer and an analysis method thereof. Specifically, the present invention provides an apparatus and method for measuring the electrical resistance, reactance, and impedance of a human body using a bioelectrical impedance (BIA) method, and analyzing and evaluating the state of components constituting the human body .

The apparatus for analyzing a human body component according to an embodiment of the present invention includes: a constant current generating circuit unit for supplying a constant current to a specific region of a human body; An alternating-current generating circuit unit for supplying alternating current to a specific portion of the human body separately from the constant current generating circuit unit; And a mixing circuit unit for mixing the generated constant current and alternating current to measure the internal resistance at a specific site of the human body.

In the human body component analyzing apparatus according to an embodiment of the present invention, reactance or impedance is further measured in the mixing circuit section.

In the human body composition analyzing apparatus according to an embodiment of the present invention, the specific region of the human body is a muscle or a skeletal muscle.

In the human body component analyzing apparatus according to an embodiment of the present invention, the mixing circuit unit is composed of a CMOS circuit.

The BIA method is a method of obtaining resistance, reactance, and impedance obtained by flowing alternating current of a certain frequency to a human body. Among the properties that interfere with the current flow obtained by the BIA method, the quantity of human body constituents of quantitative body water, fat, and fat can be obtained by using a regression equation using the impedance as the body water. In other words, the BIA method has a principle that can explain not only the indirect process of obtaining the impedance as the body water by the regression equation but also the human body configuration according to the direct values of resistance, reactance, and impedance itself. Therefore, the resistance directly obtained by the BIA method can provide information on the quantitative component of the body water and the size of the human body, and the reactance is a function of the cell mass and the structural integrity of the cell in the human body, And the like. The phase angle, which represents the relationship between the two, is expected to provide information that can be used to diagnose, assess, and track the prognosis of the body's constituent, nutritional status, and disease.

FIG. 1 is a view showing phase angle by the resistance R and the reactance Xc in the BIA method. FIG.

In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may unnecessarily obscure the subject matter of the present invention. In addition, the terms described below are established in consideration of the functions of the present invention, and these may vary depending on the intention of the manufacturer or custom in the industry, and the definition should be based on the contents throughout the specification.

The BIA method is a method (TWB = ρ × Z index) for measuring the body water by obtaining an impedance index (Z index = Z 2 = Z) obtained by flowing a fine alternating current through the human body. Since body water is present at a ratio of 0.73 (TBW = FFM × 0.73) in the fat, the ratio of 0.73 to body water is applied (FFM = TBW ÷ 0.73) to obtain fat, You can get fat. Currently, the commonly used BIA method is used in the same way as above, because the relationship between the human body's inherent conduction constant (ρ) or the TWB and Z index to the residual is dependent on age, sex, race and disease status. The body water content is obtained by using a regression equation that takes the TWB = p × Z index template and the empirical variables together with the Z index (Azcue, Wesson, Neuman, & Pencharz, 1993: Baumgartner, Chumlea & Roche 1988: Heymsfield, Lohman, Wang, & Going, 2005: Heyward, & Wagner, 2004).

The BIA method assumes that body water accounts for 0.73 of body fat in the process of obtaining body water and fat, and the process of obtaining the regression equation to obtain body water is an inevitable process for obtaining body composition, . For example, the assumption that 0.73 of fat is responsible for body water is not applied collectively to everyone. Although there is no significant difference from 0.73 for general adults, the range of body water increases to 0.80 in the case of young infants, athletes, and patients, and the error of body fat percentage due to this increases to 8% (Heymsfield, Lohman, Wang, & Going, 2005. Ellis, 2000: Heymsfield, Wang, Baumgartner, & Ross, 1997).

In addition, the regression equation for obtaining body water should include age, sex, and race, and therefore, there is a problem that the regression equation for each age, sex, and race has a problem to be solved. . In summary, the ratio of O. 73 to fat in body water used in the BIA method can not be applied to all people constantly, and it is difficult to apply a regression considering the appropriate age, sex, and race in the process of estimating the impedance index as body water The problem is that we have to use expressions. Therefore, estimating the human body composition through the BIA method is accurate for a limited group of healthy adults, and the estimation of body composition for the BIA method is inaccurate if it is outside this range (Barak, Wall-Alonso & 2003: Barbosa Silva, Barros Post, Waitzberg, & Heymfield 2003: Ellis 2000: Heymsfield Lohman Wang, & Going 2005. Heymsfield Wang, Baumgartner & Ross 1997: O'Brien Yung, &Amp; Sawka. MN 2002).

However, the result of the human resistance factors obtained by the BIA method does not obtain only the impedance index. The AC current sent to the human body by the BIA analyzer obtains the resistance value obtained by passing the body water flowing in parallel with the current flow, and the capacity reactance which produces resistance in the plasma membrane of the cell having the structure like the battery (Baumgarner et al. 1988: Barnett and Bagno, 1986), which is the inverse tangent of the impedance versus resistance versus reactance, 1980: VanderJagt, Huang, and Bhatia, 1936: Kyle Gentn, Slosman & Pichard, 2001: Lukaski & Bolonchuk, 1987: Barnett, 1937, Spence, Baliga, Nyboer, Sdftick, & Fleischmann, 1979: Subramanyan Manchanda. Chuang, Bonnet. &Amp; Glew, 2002). These human resistance factors show sensitive changes according to the functional state of the human body. Therefore, the BIA method can not directly estimate the body composition using the resistance value itself, rather than estimating the 0.73 assumption of the fat and the regression equation for body water estimation. Can be measured and evaluated. It is also possible to diagnose the disease state and evaluate the prognosis and nutritional status.

In this patent, the characteristics of human resistance factors obtained by the BIA method, not the body water estimation of BIA, which are currently used universally, are discussed, and the principle of evaluating the constitution state of the human body is discussed.

First, we examine the electrical resistance in the BIA method.

In electric phenomena, the flow of electrons is current, and the property that interrupts the flow of electrons is resistance (R), expressed in ohms (Ω ) . Every object has the property of electric resistance against current, and each object has a unique resistance value (ρ, resistivity) for current. For example, iron is a good conductor with inherent electrical resistance 10 times lower than that of nichrome. Even if the same material has the same resistance, the resistance varies depending on the size (thickness) and length of the cross-sectional area. The larger the cross-sectional area of the resistor, the smaller the resistance. That is, when the length doubles, the resistance doubles. When the cross-sectional area doubles, the resistance decreases to 1/2. Thus, the resistance is proportional to its length and inversely proportional to the cross-sectional area. The above contents are in accordance with Ohm's law, and the expression is like a heart.

The unit of resistance is μΩ, the unit of length is cm, and the unit of cross section is cm 2.

In the above equation, ρ is the resistance value (resistivity) of an object-specific current, and L is the length of the object (height: height of the human body). A is the cross-sectional area of the object (circumference in the case of the human body). When an alternating current is sent to the human body, a current flows through the body water having the electrolyte and a resistance (R) is generated. According to Ohm's law, the resistance is proportional to the length of the body water that serves as the conductor of the current and is inversely related to the cross-sectional area. For example, if the length of the human body containing body water increases from 1 to 2 times, the resistance will double. In addition, if the cross-sectional area of the human body containing body water increases from 1 to 2 times, the resistance decreases inversely from 1 to 0.5 times. Because resistance to current in the human body is due to body water, Ohm's law allows the resistance to reflect the length of body water and the degree of cross-sectional area in the body. The body water is contained in our human body, so the length of the human body (height, height) becomes longer and the length of the body water becomes longer. In other words, when the length of the kidney is lengthened, the length of the body water is also opened, and the resistance value against the current increases proportionally. In addition, as the circumference of the human body becomes larger, the cross-sectional area of body water becomes larger (Bosy-Wstphal, Danielzik, Dorhofer, Piccoli, & Muller 2005: Barbosa Silva, Barros Wang, Heymsfield. & Kim, 2007). Therefore, the resistance value is decreased in inverse proportion. The resistance value obtained by the BIA method can obtain information about the circumference of the body by obtaining a resistance value (R / H: Ω / m) divided by the elongation (unit: m) per unit length. In other words, it can reflect the thinness of the body or the heavy body. For example, an increase in the resistance per unit elongation (Resistance / Height. R / H) means that the cross-sectional area, that is, the body circumference is larger. If the resistance of the muscles increases and the body circumference increases, the resistance value will decrease. Conversely, a reduction in body size through severe weight loss results in a relatively increased resistance per kidney because the kidney is unchanged and the body circumference is reduced. As a result, the resistance R obtained by the BIA method can give information on the volume of the body water and the extension and circumference of the human body. In particular, if the resistance is corrected to the resistance value per extension, it can be used as a factor to obtain information on the size of the human body (Bosy Wstphal., Danielzik, Dorhofer, Piccoli, & Muller, 2005: Barbosa-Silva. Pillon. & Dumler 2002: Kim et al. 2007).

Second, the reactance in the BIA method is examined.

A capacitor (or capacitor) is a device that stores charge. When AC voltage is applied to the capacitor that accumulates the charge, charging and discharging are repeated. At this time, the capacitors generate a force to impede the current, which is the capacitive reactance (Xc), and the unit uses the same ohm (Ω) as the resistance (R). If an electric current flows in an electric circuit having an alternating current, a resistance which interrupts the current occurs in the circuit conductor (conductor), and a reactance which interrupts the current is generated in the capacitor. The BIA method for evaluating the human body component obtains the reactance (Xc) with the resistance of the human body, since the AC current is sent to the human body (Azcue et al., 1993: Baumgartner, Chumlea, & Roche, 1988: Heymsfield. Wang, & Going, 2005: Heyward. & Wagner, 2004). The resistance of the body occurs when the charge flows through the body as a conductor, and the reactance occurs in the plasma membrane of the cell, which is a living constituent unit of the human body. The circular membrane of the cell induces a potential difference around the plasma membrane by the osmotic pressure and the electrolyte concentration difference while bounding the intracellular fluid and the extracellular fluid. This potential difference can be caused and maintained by the structure of the cell's plasma membrane. The plasma membranes of the cells are formed by two layers of lipoproteins that form a lipid layer inside and both outer layers of the lipid layer form a protein layer. At this time, the fat layer serves as an insulator, and both protein layers serve as conductors. Such a structure acts as a capacitor when alternating current flows and has reactance to current (Baumgartner. Chumlea. & Roche 1988: Heymsfield. Lohman. Wang, & Going 2005: Heyward.

The capacitance and reactance of the capacitor to the alternating current in the human body are as follows.

Capacitance capacitor that can collect a charge Pico ferrets _(picofarads, Capactance picofarads) is, 1 × 10 ^{- 12,} the constant value 2 and pi (π, 3.1425) value and the frequency value of 50000Hz (50 kHz) and the reactance value (Xc _parallel ). In this equation, the frequency is fixed at 50 kHz. Therefore, only the reactance value is a variable, and thus the capacitor capacity is determined. The value of the molecule in the equation is a fraction, which causes the reactance value to increase proportionally with the capacitance of the condenser. Conversely, when the capacitance of the capacitor increases, the reactance value increases. The role of the capacitor in the human body is the plasma membrane of the cell, so the capacitance of the capacitor is determined in proportion to the structural integrity of the plasma membrane and the plasma membrane. In other words, as the number of cells increases or as the size of cells increases, the capacity of the capacitor increases. Also, the higher the structural integrity of the plasma membrane, the greater the capacity of the capacitor. For example, an increase in muscle cell size through resistance exercise increases the size of the plasma membrane, thereby increasing the capacity of the condenser. On the other hand, when terminal cancer patients gain severe weight loss, the capacity of the capacitor decreases due to the decrease of somatic cells. The capacitance of the capacitor was obtained by the reactance. In particular, by dividing the reactance by the elongation (unit: m), it is possible to estimate the reactance value per unit of extension (Xc / H, Ω / m) to obtain the density for the cell mass of the human body, which gives information on how much the cell mass per 1 meter (m) of the kidney is, People with cell mass can give information about body weight, especially fat or muscle mass. In addition, the large reactance value per unit of extension indicates the structural completeness of the cell and thus the possibility of its activation. Therefore, by using the reactance (Xc) or the reactance per unit of extension (Xc / H), the density of the cell mass and the cell mass of the human body, the structural integrity of the cell and the development of the function can be grasped (Azcue. Et al., 1993 : Baumgartner, Chumlea. & Roche, 1988: Heymsfield, Lohman, Wang, & Going, 2005: Heyward.

Third, we examine the impedance in the BIA method.

When a human body sends an alternating current, the body generates resistance (R) and reactance (Xc). The resistance R is an action that interrupts when the current flows along the body water, and the reactance Xc is an action that interrupts the current flow in the plasma membrane of the cell as the current flows through the AC. Impedance (Z) is the sum of the resistance and the reactance that impedes the flow of current. Classically, bioelectrical impedance analysis (BIA) is a method of using impedance to obtain body fat. Impedance is the square of the resistance multiplied by the square of the reactance. The formula for this value is as follows, and the unit is impedance, resistance, and reactance in both ohms.

Z ² = R ² + Xc ²

Currently, the BIA method for analyzing human body components uses impedance Z. Impedance is proportional to the length of the conductor with the inherent resistivity (rho) and inversely proportional to the cross-sectional area

Also, in the above equation, the value of the equation does not change even if the length (L) of the molecule and the cross-sectional area (A) of the denominator are multiplied by a unit of length in the same way. The denominator is the product of the length of the denominator and the denominator of the length. The cubic of the length is the unit in which the volume can be obtained. Therefore, when the impedance is obtained, the volume of the conductor through which the current flows can be known, and the impedance of the human body is an impedance to the body water, so that the volume of the body water is obtained

In the above equation, the expression for the volume is changed as follows.

The volume for the body water is determined by L ² / Z with respect to the resistivity (ρ) which is a constant value inherent to the body water. Therefore, if we know the inherent constant value for body water, we can know the volume of body water by finding L ² / Z, L ² can be obtained by squaring the height, and Z can be found by obtaining the impedance value for current. Therefore, the body water of the human body can be obtained by obtaining the elongation and the impedance value. Again, the impedance equation for the body water is obtained as follows.

In the above equation, H ² / Z is called the impedance index. Ultimately, in order to obtain the body composition by the current BIA method, the body water index is obtained by obtaining an impedance index. The body water is assumed to be present in the fat to a ratio of 0.73. When the body water is obtained by using the impedance index, the fat is divided by the ratio of 0.73 of body water. When you get the fat, the body's fat is subtracted from the body fat to become fat. In summary, the impedance index can be obtained by obtaining the body water and recovering the fat. In the present study, the BIA method was used to derive body mass, mass, and fat based on the above theory (Azcue, et al., 1993: Baumgartner, Chumlea, & Roche, 1988: Heymsfield, Lohman, Wang, & Going, 2005: Heyward. &Amp; Wagner, 2004).

However, in order to obtain the body water by the BIA method, it is necessary to determine the constancy value specific to the body water before using the impedance index by the BIA method. Unfortunately, the intrinsic constant for the resistivity (ρ) of body water is not consistent for all people and is affected by empirical variables such as age, weight, sex, and race, so resistivity is obtained using a regression equation that takes into account empirical variables .

(Barak, Wall-Alonso, & Sitrin 2003: Barbosa Silva, Barros Post, Waitzberg, & Heymfield, 2003: Ellis, 2000: Heymsfield, Lohman. Wang, & Going, 2005, Heymsfield, Wang, Baumgartner, & Ross, 1997: O'Brien, Yung, & Sawka, MN 2002). The first problem is that the resistivity (ρ) to be considered together with the impedance index is affected by several empirical variables. As mentioned above, since the resistivity (ρ) is affected by age, race, sex, and weight, a regression formula that solves each empirical variable should be sought. Regression equations for empirical variables have to be obtained from subjects with sufficient number of cases and have problems to be applied to the group considered in the regression equation even when estimating body composition. The second problem is that the impedance index obtained from the BIA method is used for all subjects assuming that body water accounts for 0.73 of body fat when body fat is obtained and body mass is obtained. It accounts for about 0.73 of the province. However, in young children, body water accounts for a high water content of 0.81 to 0.75% of fat. For athletes, bodybuilders with high muscle mass occupy 0.75 of fat. On the other hand, the ratio of 0.73 of body fat to body water does not apply to patients with disease. Therefore, the body water and the body composition can be obtained by applying the BIA method only to a limited number of groups and to be accurate. Estimation of the body water using the impedance index has the advantage of obtaining a quantitative amount. However, it has problems that can be used only for limited groups. Resolving these problems and evaluating the body composition state directly uses the impedance, resistance and reactance obtained from BIA. The resistance obtained by the BIA can predict the state of the body water, and the reactance can obtain the cell body mass and the structural state of the cell, and the impedance can tell the relative position of the resistance and the reactance.

Fourth, we will look at phase angle in BIA method.

When the AC current is sent to the human body using the BIA method, the result directly obtained is the value of the electric resistance R and the reactance Xc that interfere with the current flow. Then, the value of the impedance Z which is the sum of squares is obtained (R ² + Xc ² = Z ² ). The impedance is not only a quantitative value for the electrical resistance and reactance value but also the vector value and the trigonometric relationship (Baumgarner, et al., 1988: Barnett, 1937: Barnett and Bagno, 1936: Kyle 1979: Subramanyan and Bhatia, 1980: VanderJagt, Huang, Chuang, Bonnet, and Glew, 1979: Subramanyan and Bhatia, 1980 , 2002). As shown in Fig. 1, when the elements of the value of the vector form a triangle, the base is the resistance and the upper side is the reactance. The impedance, which is the value of the hypothetical vector, is obtained. The inverse tangent of the reactance divided by the resistance is calculated. The value of the phase angle which is the angle of the hypothetical impedance is obtained (Fig. 1).

The value of the phase angle can have a value from a maximum of 90 ^° to a minimum of 0 ^° . If the phase angle is 0 ^{°, the} reactance value is 0 and only the value of the resistor is shown. On the other hand, when the phase angle is 90 ^{°, the} reactance value is maximum. As a result, the phase angle represents the value of the reactance of the relative resistance. As the reactance increases, the phase angle increases, while the phase angle decreases proportionally as the reactance decreases. Reactance to alternating current is proportional to the integrative function of the cell's plasma membrane and cells in the human body. Therefore, the increase of the plasma membrane proportionally increases the reactance. The increase in the completeness and function of the plasma membrane structure of the cells leads to an increase in the phase angle, while the decrease in the structural damage and function in the plasma membrane of the cell leads to a decrease in the phase angle.

In the related studies reported, the male had a higher phase angle than the female, and the age of the male and female groups was increased from adult to elderly in each age group, Barbosa-Silva, et al., 2005: Kim et al., 2007). The difference in phase angle according to gender is greater in males than females, and therefore the amount of cells is high and the phase angle is high. In addition, the age of both men and women was lower as the aging progressed. The low phase angle is caused by the decrease of the cell mass due to aging and the decrease of the phase angle due to the degradation of the structure and function of the plasma membrane of the cell (Barbosa-Silva, et al., 2005: Kim. et al., 2007).

In another report, athletes in the human body had a higher phase angle than the same general population, whereas patients with anorexia or severe fat loss had significantly lower phase angles (Kim, Kim, Park Park, & Kim, 2007: Piccoli 1998: Toso, Piccoli, Gusella, Menon, Bononi, Crepal0l =, & Ferrazzi 2000). The athlete adapted to the exercise develops organs of the human body due to the development of strength, muscular endurance and heart ablation, and the mass of the developing organs increases at this time. The increased mass of the human body is actually due to an increase in cell mass, which increases the phase angle. Another reason for the increase in phase angle is that the adaptation to muscle development and exercise improves cell function, and the phase angle of cell membrane structural integrity and functional development is high (Kim, Kim, Park, & Kim ). On the other hand, patients with anorexia weight loss (BMI less than 18.5) showed low phase angle due to decrease of cellular mass and decreased function of body. In patients with chronic renal failure, the survival probability within 1 year was lower than the lower limit of phase angle of normal subjects, and the survival rate of patients with chronic renal failure was higher when the phase angle was maintained at normal level (Kim, Piccoli, 1998: Toso, Piccoli, Gusella, Menon, Bononi, Crepaladi, & Ferrazzi, 2000). In addition, the phase angle is related to the level of the cell mass in the body, the functional state, and the quality of the disease. As a measure of the level of education. These information can be easily and easily determined by the BIA in a short time, and can be used to determine the nutritional status of the human body. In particular, it is claimed that it is possible to use it as a practical method for application to diagnosis, evaluation and prognosis of nutritional status and disease of patients. However, until now, sufficient research, research results and achievements have been lacking. The normal distribution of the phase angle varies according to race and gender. Therefore, there is a problem that the normal distribution of the reference group according to the race should be presented. The problem of the reference value and the evaluation method of the nutritional state and the human body constitution state is a problem to be solved It remains.

Therefore, the BIA method is a method of obtaining resistance, reactance, and impedance obtained by flowing alternating current of a constant frequency to a human body. Among the properties that interfere with the current flow obtained by the BIA method classically, impedance was used as the regression equation by the body water, and quantitative body water, fat, and the amount of the constituent components of the fat were obtained. However, the classical BIA method has a principle that can explain not only the indirect process of obtaining the impedance by the regression equation but also the body composition according to the direct values of resistance, reactance and impedance itself. The resistance directly obtained by the BIA method can provide information on the quantitative component of the body water and the size of the human body. Reactance can be obtained by analyzing the structural integrity of the cell mass and the cell structure Provide information to do. It is also expected that the phase angle, which represents the relationship between the two, can provide information to diagnose, evaluate, and track the prognosis of the condition, nutritional status, and condition of the human body.

In recent years, attempts have been made to use the BIA method to assess muscle damage and injury. Lower extremity muscle injuries are common among soccer players, and soft tissue hydration and cell membrane integrity can be analyzed noninvasively using the BIA method. In addition, the BIA method can be used to analyze the effects of muscle injury and recovery on BIA parameters. In order to measure the degree of muscle damage and the changes in the BIA method parameters during recovery, three male soccer players were subjected to a series of four serial tetra-polar trains for the thigh muscles, hamstrings, and calf muscles of the soccer players, polar and phase sensitive 50 kHz. The BIA parameters are resistance (R), reactance (Xc) and phase angle (PA). The resistance (R), the reactance (Xc), and the phase angle (PA) of muscle damage are compared with the resistance (R), reactance (Xc) (23.1%, 45.1% and 27.6%), grade II (20.6%, 31.6% and 13.3%) and grade I (11.9%, 23.5% and 12.1%), respectively. Here, grade III is a group in which the torn part of the muscle is entirely extended and the muscular function is completely lost, and grade II is a degree of damage to a part of the function such as muscle contraction and relaxation, Grade I is a group of weak muscle injuries, with only some of the muscle fibers being torn and having some discomfort with movement.

From this, it can be seen that the decrease in the resistance (R) indicates that lactic acid accumulation has occurred, and the decrease in reactance (Xc) and phase angle (PA) values indicates that the preservation of the cell membrane is collapsed and damaged. Thus, by measuring the BIA parameters for the thigh muscles, hamstring, and calf muscles as described above, the damage and fatigue of the soft tissue can be actually detected and analyzed.

Therefore, according to one embodiment of the present invention, BIA parameters are measured through the BIA method on the thigh muscles, hamstrings, calf muscles, and skeletal muscles that are specific parts of the human body, and the degree of damage, fatigue, Able to know. This can be achieved by using magnetic resonance imaging (MRI) to measure the resistance values (R), reactance (Xc), impedance (Z) and phase angle (PA) of the BIA method and the degree of damage and fatigue Can be known. As a result, it is possible to quantitatively and qualitatively analyze the specific region from the values of the BIA method using the BIA method for a specific region of the human body.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, It will be understood that various modifications and applications are possible. For example, each component specifically shown in the embodiments can be modified and implemented. It is to be understood that all changes and modifications that come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

Claims (4)

An apparatus for analyzing components constituting a human body using a bioelectrical impedance method,
A constant current generating circuit part for supplying a constant current to a specific part of the human body;
An alternating-current generating circuit unit for supplying alternating current to a specific portion of the human body separately from the constant current generating circuit unit; And
And a mixing circuit unit for mixing the generated constant current and alternating current to measure an internal resistance at a specific site of the human body.
The method according to claim 1,
And the reactance or impedance is further measured in the mixing circuit section.
The method according to claim 1,
Wherein the specific region of the human body is muscle or skeletal muscle.
The method according to claim 1,
Wherein the mixing circuit unit comprises a CMOS circuit.

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