KR20170048040A - Flexible and human implantable probe apparatus - Google Patents

Flexible and human implantable probe apparatus Download PDF

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Publication number
KR20170048040A
KR20170048040A KR1020150148907A KR20150148907A KR20170048040A KR 20170048040 A KR20170048040 A KR 20170048040A KR 1020150148907 A KR1020150148907 A KR 1020150148907A KR 20150148907 A KR20150148907 A KR 20150148907A KR 20170048040 A KR20170048040 A KR 20170048040A
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KR
South Korea
Prior art keywords
flexible
probe device
nanostructure
human body
body insertion
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KR1020150148907A
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Korean (ko)
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KR101762675B1 (en
Inventor
장재은
이윤구
류민규
안유미
Original Assignee
재단법인대구경북과학기술원
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Priority to KR1020150148907A priority Critical patent/KR101762675B1/en
Publication of KR20170048040A publication Critical patent/KR20170048040A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • B82B1/001—Devices without movable or flexible elements
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
    • H01B5/00—Non-insulated conductors or conductive bodies characterised by their form

Abstract

The present invention relates to a flexible probe device implantable in a human body. The flexible probe device implantable in a human body according to one aspect of the present invention comprises: a flat composite electrode which supplies power from the outside, has a flexible structure, is bent and disposed on a flexible substrate; a nanostructure protruding upward from the substrate to form a bundle; and a metal thin film coated on the structure and a conductive organic structure.

Description

[0001] FLEXIBLE AND HUMAN IMPLANTABLE PROBE APPARATUS [0002]

The present invention relates to a human insertion type probe apparatus.

Surface Electrode has advantages of being universally used and easily handled due to its non-invasive characteristics. However, the simple metal surface electrode according to the prior art has a high impedance in sensing or stimulating a biological signal, There is a problem in that it is difficult to make a meaningful sense since the rain does not become large.

In addition, the simple metal surface electrode according to the related art has a problem that power consumption at the time of stimulation increases, and damage to the brain or body organs may occur.

In addition, the simple metal surface electrode according to the prior art has a problem in that the flexibility is poor, and the electrodes are disconnected at the time of surgery, and the external connection portion is disconnected after inserting into the human body.

SUMMARY OF THE INVENTION It is an object of the present invention to provide a flexible human insertion type probe device which enhances the surface area and the adhesive force and secures biostability and operational reliability.

The flexible human body-inserted probe device according to one aspect of the present invention includes a nano-structure including a planar composite electrode which is supplied with power from the outside and is manufactured and bent in a flexible structure, .

The flexible human implantable probe device according to the present invention has the effect of enhancing the surface area and the adhesive force by using the nanowire or nanotube structure.

In addition, the nanostructure has an effect of enhancing biostability by surface-treating the surface of the nanostructure using a biocompatible conductive organic material.

In addition, the drug which increases the wound stability between the nanostructures is stored, and the drug stored by using the capillary phenomenon is secreted little by little, thereby increasing the biostability.

In addition, it is possible to secure flexibility and high conductivity by using a flexible nano material, a conductive 2D material and a metal film, and it is possible to prevent a disconnection when the electrode is bent, thereby securing operational reliability.

In addition, since the nanostructure ultimately coats the conductive organic material on the surface thereof, it maximizes the surface electrode and facilitates the ion transfer, thereby ensuring low impedance and increasing the ratio of signal to noise, thereby securing the sensing reliability.

The effects of the present invention are not limited to those mentioned above, and other effects not mentioned can be clearly understood by those skilled in the art from the following description.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an exemplary view showing a flexible human-inserted probe device according to an embodiment of the present invention; FIG.
2 is an enlarged view of a nanostructure according to an embodiment of the present invention.
3 is an exemplary view showing a process sequence of a flexible human insertion type probe apparatus according to an embodiment of the present invention.
FIG. 4 is a view showing a feature of storing and discharging a drug between nanostructures according to the present embodiment.

BRIEF DESCRIPTION OF THE DRAWINGS The advantages and features of the present invention, and the manner of achieving them, will be apparent from and elucidated with reference to the embodiments described hereinafter in conjunction with the accompanying drawings. The present invention may, however, be embodied in many different forms and should not be construed as being limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. And is intended to enable a person skilled in the art to readily understand the scope of the invention, and the invention is defined by the claims. It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. In the present specification, the singular form includes plural forms unless otherwise specified in the specification. It is noted that " comprises, " or "comprising," as used herein, means the presence or absence of one or more other components, steps, operations, and / Do not exclude the addition.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the drawings.

FIG. 1 is an exemplary view showing a flexible human insertion type probe device according to an embodiment of the present invention, and FIG. 2 is an enlarged view showing a nanostructure according to an embodiment of the present invention.

The flexible human implantable probe apparatus according to an embodiment of the present invention includes a plurality of structures shown in FIG. 1 and is disposed on a flexible substrate. Hereinafter, in order to facilitate the understanding of those skilled in the art, do.

The flexible human insertion type probe device according to an embodiment of the present invention includes a planar composite electrode 100 that is supplied with power from the outside and is manufactured and bent in a flexible structure, And a nano structure 200 protruding in a direction opposite to a plane where the planar composite electrode 100 and the substrate abut (upper direction with reference to Fig. 1) are formed as a bundle.

The nanostructure 200 according to an embodiment of the present invention is different from the conventional nerve probe in that the nanostructure 200 is formed as a bundle and has a probe shape. (Upward direction with reference to Fig. 1), and protrudes in the vertical direction.

The nanostructure 200 according to an embodiment of the present invention includes a nanowire or nanotube 210, a metal thin film 220 deposited thereon, and a conductive organic material 230, as shown in an enlarged view of FIG. .

According to the embodiment of the present invention, it is possible to maximize the surface area by using the planar composite electrode 100 and the vertically grown nanostructure 200, and the conductive organic material 230 is finally coated on the surface to increase the surface area It is possible to reduce ion transfer energy at the same time.

The conductive organic material may be PEDOT or the like, and a metal thin film 220 is formed between the nanostructure 200 and the conductive organic material 230 to improve the electrical bonding property.

The nanostructure 200 according to the embodiment of the present invention is preferably formed to have a predetermined diameter (tens to hundreds of nanometers) and a length (several micrometers to millimeters).

The nanostructure 200 may be formed of any one of a ZnO wire, a CNT tube, an Al 2 O 3 (alumina) tube, a TiO 2 tube, and a metal wire. , And a capillary phenomenon is used between the respective structures to store and secrete a drug (wound-stabilizing drug) that increases the stability of the wound.

That is, the wound stabilization drug 300 is stored as a capillary phenomenon between the nanostructures 200, and is secreted little by little, so that it has an effect of enhancing biostability in applying the insertion method of the human body.

A planar composite electrode according to an embodiment of the present invention is formed by using a composite material of a flexible nano material and a metal thin film. The flexible nano material may be a 2D material such as Graphene, NbS, MoS, NBs, NbSe2, And an oxide conductive thin film such as ITO other than Au, Ag, Ti, Al, Cr, Mo, and Nb may be used as the metal thin film.

Such a flat composite electrode can prevent a disconnection when the electrode is bent, and it is possible to secure operational reliability.

FIG. 3 is a view showing a process sequence for a flexible human insertion type probe apparatus according to an embodiment of the present invention, wherein (a) shows a planar composite electrode 100, (b) shows a nanowire / 210 are formed.

Next, (c) shows the deposition of a metal. In this case, the metal thin film 220 is not limited to the kind but various metals can be used.

(D) is a diagram showing deposition of the conductive organic material 230 finally. As shown in the figure, by coating the conductive organic material 230 on the final surface, the flexible human insertion type probe apparatus according to the embodiment of the present invention It is possible to maximize the surface area and facilitate the ion transfer, thereby further lowering the impedance.

The embodiments of the present invention have been described above. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the disclosed embodiments should be considered in an illustrative rather than a restrictive sense. The scope of the present invention is defined by the appended claims rather than by the foregoing description, and all differences within the scope of equivalents thereof should be construed as being included in the present invention.

100: plane electrode 200: nanostructure
210: nanowire, nanotube 220: metal thin film
230: conductive organic material 300: drug

Claims (8)

A planar composite electrode that is supplied with power from the outside, is made of a flexible structure and is bent, and is disposed on a flexible substrate,
A nanostructure protruding upward from the substrate to form a bundle; a metal thin film coated on the nanostructure and a conductive organic material
A flexible body insertion type probe device.
The method according to claim 1,
The planar composite electrode is formed using a composite material of a flexible nano material and a metal thin film, and the flexible nano material is formed using a nanowire electrode having a 2D material and a network
Flexible human body insertion probe device.
3. The method of claim 2,
The 2D material is any one of graphene, NbS, MoS, NBs, and NbSe2
Flexible human body insertion probe device.
3. The method of claim 2,
Wherein the metal thin film is an oxide conductive thin film of Au, Ag, Ti, Al, Cr, Mo, Nb or ITO
Flexible human body insertion probe device.
The method according to claim 1,
Wherein the nanostructure protrudes in a vertical direction with respect to the substrate and is a nanowire or a nanotube and is coated with the metal thin film to improve electrical bonding between the conductive organic material and the nanostructure, Coated with organic matter
Flexible human body insertion probe device.
6. The method of claim 5,
The nanostructure may be formed of any one of ZnO wire, CNT tube, Al2O3 tube, TiO2 tube and metal nanowire
Flexible human body insertion probe device.
The method according to claim 1,
The bundle of nanostructures is formed by storing a drug which increases the stability of the wound using capillary phenomenon between the respective structures and secretes the drug
Flexible human body insertion probe device.
The method according to claim 1,
Wherein the nanostructure is formed to correspond to a predetermined diameter and length
Flexible human body insertion probe device.
KR1020150148907A 2015-10-26 2015-10-26 Flexible and human implantable probe apparatus KR101762675B1 (en)

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KR1020150148907A KR101762675B1 (en) 2015-10-26 2015-10-26 Flexible and human implantable probe apparatus

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KR101762675B1 KR101762675B1 (en) 2017-07-28

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8333874B2 (en) * 2005-12-09 2012-12-18 Flexible Medical Systems, Llc Flexible apparatus and method for monitoring and delivery
KR20110057989A (en) 2009-11-25 2011-06-01 삼성전자주식회사 Composite structure of graphene and nanostructure and method of manufacturing the same

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