KR20170015316A - Sake-yeast-containing tablets - Google Patents

Abstract

Disclosed is a sake yeast-containing tablet having sufficient refined properties such as hardness and collapsibility even when a large amount of sake yeast is mixed in one sieve. That is, the present invention relates to a tablet containing sake yeast and crystalline cellulose, wherein the sake yeast body is contained in the purified product in an amount of 15 mass% or more and the mass ratio (B) of the crystalline cellulose content to the content of the sake yeast body (A) (B / A) of 1.3 or more.

Description

[0001] SAKE-YEAST-CONTAINING TABLETS [

The present invention relates to a tablet containing cheongju (yeast) yeast.

Cheongju yeast is rich in nutrients such as vitamins, amino acids, plant fiber and minerals. The intake of sake yeast is helpful for nutritional support. In addition, the sake yeast has a relatively large amount of S-adenosylmethionine (SAMe), which is effective for joint pain, liver function improvement, depression (depression), growth hormone secretion promoting action, (Patent Literature 1, 2, etc.), and the ingestion of sake yeast can also be expected to have these effects.

Patent Document 1: International Publication No. 2012/121140 Patent Document 2: International Publication No. 2013/051728

In order to obtain the above effect, it is necessary to take a relatively large amount of sake yeast. Therefore, when sake yeast is purified, when the amount of sake yeast contained in one tablet is low, the amount of purified water to be consumed is increased, and the solubility is deteriorated. In order to reduce the amount of purified water to be consumed, it is conceivable to increase the amount of sake yeast contained in one sieve. However, if the amount of sake yeast contained in one sake is increased, the formability becomes worse and the hardness ), It is necessary to add an appropriate additive. However, if an additive such as an excipient is merely added, the problem of disintegration may occur, or the amount of sake yeast contained in one tablet may be relatively small, resulting in an increase in the amount of purified water to be consumed.

The present invention has been made in view of the above problems, and an object of the present invention is to obtain a tablet containing sake yeast having sufficient refined properties such as hardness and collapsibility even when a large amount of sake yeast is contained in one sieve.

In order to solve the above-mentioned problems and to achieve the object, the inventors of the present invention have extensively studied about the kinds of the additives added to the sake yeast-containing tablets and the amount thereof. As a result, it has been found that the amount of the crystalline cellulose of the sake yeast- It has been found that a tablet having sufficient purification properties can be obtained even when a large amount of sake yeast is mixed in one tablet, thereby completing the present invention.

That is, the present invention provides the following invention.

[1] A tablet containing sake yeast and crystalline cellulose, wherein the sake yeast cell body (A) is contained in the purified product in an amount of 15 mass% or more and the mass of the content of the crystalline cellulose (B) relative to the content of the sake yeast cell body A tablet (tablet) having a ratio (B / A) of 1.3 or more.

[2] The tablet according to [1], further comprising carboxymethylcellulose calcium (C).

[3] The tablet according to [1] or [2], which contains not less than 23% by mass of sake yeast organism strain (A).

[4] The tablet according to any one of [1] to [3], wherein the crystalline cellulose (B) has a bulk density of 0.3 g / cm 3 or less.

[5] The tablet according to any one of [1] to [4], wherein the crystalline cellulose (B) has an average particle diameter of 100 μm or less.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide tablets having good refinement properties such as hardness and collapsibility.

<Cheongju yeast>

The tablet of the present invention contains syrup yeast. Cheongju yeast is a yeast used in brewing sake. The yeast used for sake brewing is mainly classified as S. cerevisiae and Saccharomyces cerevisiae. As the Cheongju yeast, yeast (K-6), K-7 yeast, K-9 yeast, K-601 yeast, K-601 yeast -701), Association No. 901 Yeast (K-901), Association Association No. 1001 Yeast (K-1001), Association Association No. 1501 Yeast (K-1501). Cheongju yeast may be either live cells or dead cells.

Cheongju yeast is usually dried bacterium. A dried cell is a result obtained by drying a part of cells such as a crushed piece of a cell and / or a cell. Examples of the drying treatment include freeze drying, vacuum drying, air drying, and spray drying. The dried cells are usually in powder form.

The content (dry mass) of the sake yeast cell body (A) relative to the mass of the tablet of the present invention is usually 15% by mass or more, preferably 20% by mass or more, more preferably 20% By mass is not less than 23% by mass. As a result, the ingestion constant can be suppressed to an appropriate range, so that the dosage can be improved. The upper limit is preferably 70 mass% or less, more preferably 60 mass% or less, still more preferably 50 mass% or less. Thereby, sufficient hardness and good collapsibility can be obtained as tablets. The content of one tablet per tablet of the sake yeast organism (A) is preferably 15 mass% to 70 mass%, more preferably 20 mass% to 60 mass%, still more preferably 23 mass% to 50 mass% Do.

The sour flavor yeast body (A) in the tablet of the present invention is contained in sake yeast. The syrup yeast and the syrup yeast body (A) may be the same. In addition, components other than sake yeast organism strain (A) may be contained in syrup yeast. Examples of components other than the sake yeast organism (A) include a fermentation broth, a culture supernatant, and the like.

<Crystalline cellulose>

The tablets of the present invention contain crystalline (crystalline) cellulose (B). The crystalline cellulose (B) is a cellulose having a crystal structure and may be microcrystalline cellulose (cellulose having a microcrystalline structure). The conditions for producing the crystalline cellulose are not particularly limited, and may be produced by partially depolymerizing? -Cellulose, or by hydrolyzing raw materials such as pulp to remove the amorphous portion. Crystalline cellulose (B) may also be referred to as microcrystalline cellulose. As the crystalline cellulose (B), for example, SEORAS (registered trademark) of grades such as UF, KG PH and FD manufactured by Asahi Chemical Industry Co., Ltd. may be mentioned. Preferably, Seoras (registered trademark) FD-101, Seoras (registered trademark) UF-F702, Seoras (registered trademark) UF-F711 can be mentioned.

The bulk density of the crystalline cellulose (B) is preferably 0.3 g / cm3 or less, more preferably 0.25 g / cm3 or less, and more preferably 0.1 g / cm3 or more in order to impart sufficient hardness and collapsibility to the tablet of the present invention More preferably 0.15 g / cm &lt; 3 &gt; or more. Similarly, in order to impart sufficient hardness and collapsibility to the tablet of the present invention, the average particle diameter of the crystalline cellulose (B) is preferably 100 占 퐉 or less, more preferably 80 占 퐉 or less, and even more preferably 60 占 퐉 or less , Preferably 1 mu m or more, more preferably 20 mu m or more, and still more preferably 30 mu m or more.

The bulk density can be measured based on the bulk density and tap density measurement method 2 in the General Test Methods of the Japanese Pharmacopeia 16th Edition. Specifically, a sample was uniformly supplied from above the container through a 1.0 mL sieve of JIS standard to a cylindrical container having an inner diameter of 30 mm (actual measurement volume: 25 mm), and the upper surface was cut off ). &Lt; / RTI &gt;

The average particle size was determined by measuring the average particle diameter of the crystalline cellulose (B) dispersed in water (water) and measuring the average particle diameter of the crystalline cellulose (B) by measuring the refractive index when measuring with a laser diffraction particle distribution analyzer (setting of refractive index; standard, dispersion; 1% Tween20 solution, And 50% diameter (median diameter, volume basis) in the volume-based particle size distribution.

The content of the crystalline cellulose (B) is not particularly limited. However, the content of one crystal of the crystalline cellulose (B) is usually 0.5% by mass or more, and preferably 10% by mass or more. The upper limit is 85 mass% or less, preferably 75 mass% or less. Thereby, sufficient tablet hardness and good collapsibility as a tablet can be obtained. The content of the crystalline cellulose is preferably 0.5% by mass to 85% by mass, more preferably 10% by mass to 75% by mass.

<Mass ratio of crystalline cellulose / syrup yeast>

In the tablet of the present invention, the mass ratio (B / A) of the content of the crystalline cellulose (B) to the content of the sake yeast organism body (A) is preferably 1.3 or more and 2.5 or more. As a result, it is possible to obtain tablets excellent in both hardness and collapsing property.

The upper limit of the mass ratio (B / A) is not particularly limited, but it is preferably at most 5.7, and more preferably at most 3.7. This makes it possible to maintain satisfactory tabletability.

&Lt; Carboxymethylcellulose calcium &

The tablet of the present invention preferably further contains carboxymethylcellulose calcium (also known as Carmelous calcium) (C). By blending the carboxymethylcellulose calcium (C), the collapsibility of the tablet can be further improved. The blending amount of carboxymethyl cellulose calcium (C) is preferably 0.5% by mass or more, more preferably 1% by mass or more, and further preferably 1.5% by mass or more. The upper limit is preferably 30 mass% or less, more preferably 20 mass% or less, and further preferably 10 mass% or less. The content of carboxymethylcellulose calcium (C) is preferably 0.5 to 30 mass%, more preferably 1 to 20 mass%, and still more preferably 1.5 to 10 mass%.

Other ingredients used in the production of tablets such as other medicines, quasi-drugs, foods, etc., such as excipients, binders, and the like, in such an amount as not to impair the effects of the present invention unless adversely affecting the effects of the present invention , A disintegrant, an enteric polymer, a water-insoluble polymer, a lubricant, a surfactant, a colorant, a flavoring agent, an adsorbent, an antistatic agent, a collapse extender, and a foaming agent.

Examples of the excipient include starch, corn starch, granulated sugar, mannitol, magnesium carbonate, calcium carbonate, refined white sugar, glucose, glucose, lactose, silicon dioxide (aka silicic acid anhydride, Low-substituted hydroxypropyl cellulose, and the like. The content of the excipient is not particularly limited, but is preferably 0.1% by mass to 80% by mass, more preferably 0.3% by mass to 74% by mass.

Examples of the binder include cellulose derivatives such as sucrose, gelatin, gum arabic, methylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxymethylcellulose sodium, polyvinylpyrrolidone, pullulan, Dextrin, and α-modified starch. The content of the binder is not particularly limited, but is preferably from 0.1 to 10% by mass, more preferably from 1 to 5% by mass.

Examples of the disintegrator include croscarmellose sodium, crosslinked insoluble polyvinylpyrrolidone, partially alpha-starch, crospovidone, carboxymethylstarch sodium, and cornstarch. The content of the disintegrant is not particularly limited, but is preferably 0.1 to 30 mass%, more preferably 1 to 20 mass%, in total.

Examples of the enteric polymer include hydroxypropylmethylcellulose phthalate, cellulose acetate phthalate, and carboxymethylethylcellulose.

Examples of the water-insoluble polymer include aminoalkyl methacrylate copolymers (e.g., Oidolagido E, Oidolagido RS, etc.), methacrylic acid copolymers (e.g., Oidolageto L30-55 Etc.).

Examples of the lubricant include polyethylene glycol, talc, stearic acid or a salt thereof (e.g., calcium stearate), and sucrose fatty acid esters. The content of the lubricant is not particularly limited, but is preferably 0.001 to 5% by mass, more preferably 0.01 to 3% by mass. Examples of the sucrose fatty acid esters include sucrose lauric acid esters, sucrose myristic acid esters, sucrose palmitic acid esters, and sucrose stearic acid esters. Examples of the sucrose lauric acid esters include sucrose monolaurate, sucrose dilaurate and sucrose trilactate. Examples of the sucrose myristic acid esters include sucrose monomyristate, sucrose dimyristate, sucrose triarylate and the like, sucrose palmitic acid Examples of the ester include sucrose monopalmitate, sucrose dimalmitate, and sucrose tripalmitate. Examples of the sucrose stearate ester include sucrose monostearate, sucrose distearate, and sucrose tristearate.

Examples of the surfactant include nonionic surfactants such as anionic surfactants such as sodium alkylsulfate, nonionic surfactants such as polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters and polyoxyethylene castor oil derivatives.

Examples of the coloring agent include a coloring matter such as tar color, caramel, iron oxide, titanium oxide, riboflavin, green tea extract, copper chlorophyllin sodium, edible yellow No. 5, edible red No. 2, edible blue No. 2, And the like.

Examples of the mating agent include sweeteners (e.g., artificial sweeteners such as sodium saccharin, dipotassium glycyrrhizinate, aspartame, stevia, and tautin), fats (such as lemon, lemon lime, orange, Peppermint micron X-8277-T, and dry coat green tea # 421), acidifiers (e.g., citric acid, tartaric acid, malic acid, etc.) and green tea horses.

Examples of the adsorbent include special calcium silicate (flourite) and the like.

Examples of the antistatic agent include light anhydrous silicic acid (eeloid) and the like.

As the foaming agent, for example, sodium bicarbonate and the like can be mentioned.

The preparation method of the tablets is not particularly limited, and may be assembled by wet granulation, dry granulation, or the like in accordance with necessity. Examples of other methods include a direct tableting method in which syrup yeast, crystalline cellulose and the above additives are mixed and tableted, dry granules prepared by compression molding, or a mixed solvent of water is added, ), An indirect tableting method in which wet granules are prepared by dissolving the additives in a solvent such as water, followed by spray drying to form wet granules, followed by compression tableting, and a combination thereof. Of these, the direct method is preferable.

The tablet may be coated with a coating agent. Examples of the coating agent include cellulose such as carmelose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose and ethylcellulose, synthetic polymers such as polyvinyl alcohol and polyvinylpyrrolidone, polyethylene glycol, propylene glycol, glycerin and the like Synthetic esters such as polyhydric alcohol, triacetin, triethyl citrate, and glycerin fatty acid ester, natural materials such as shellac and pullulan, and combinations thereof. In addition, optional components such as pigments such as titanium oxide and iron oxide, mannitol, cetanol, and sodium lauryl sulfate may be added as needed. It is also possible to add carnauba wax or the like as a polish agent after film coating.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide tablets excellent in the solubility and excellent in refinement properties such as hardness and collapsibility.

The hardness of the tablet can be measured using a hardness meter (for example, TH-203CP manufactured by Toyama Kogyo Co., Ltd.). When the hardness is 5 kgf or more, occurrence of problems such as cracking and distortion of tablets can be suppressed. When the tablets are subjected to a treatment such as coating, when the hardness is 6 kgf or more, the workability in the treatment can be improved.

The collapse property can be evaluated by measuring the decay time using the method described in the Japanese Pharmacopoeia General Test Methods. The decay time is preferably less than 60 minutes, more preferably less than 40 minutes. The shorter the disintegration time, the better the immediate effect.

Example

Hereinafter, the present invention will be described in more detail with reference to examples, but the embodiments of the present invention are not limited to these examples.

[Examples 1 to 6 and Comparative Examples 1 to 3]

(Manufactured by Mitsubishi Gas Chemical Co., Ltd., a cell mass of 70% in yeast powder), crystalline cellulose and carboxymethylcellulose calcium (EC G-FA, manufactured by Nichiyu Kagaku Kogyo Co., Ltd.) , Calcium stearate (calcium stearate, manufactured by Taihei Kagaku Kogyo Co., Ltd.) were added and mixed and kneaded at 5 kN by a direct method. SEALAS (registered trademark) FD-101 (manufactured by Asahi Kasei Chemicals Co., Ltd.) was used as the crystalline cellulose.

The hardness and collapse time of each tablets obtained were measured. The hardness was measured by a hardness tester (TH-203CP, manufactured by Toyama Kogyo Co., Ltd.) and was judged according to the following criteria. The disintegration time was measured by a disintegration test according to the disintegration test method of tablets collected in the 16th Japanese Pharmacopoeia, and the disintegration time (minute) was measured. Ion exchange water was used as the test solution for collapse, and the water bath temperature was set at 37 캜. The average of six measurements was calculated and judged according to the following criteria.

[Judgment Criteria of Hardness]

When the hardness was 5 kgf or more, it was judged that it was acceptable.

☆: more than 8㎏f

◎: Less than 6㎏f and less than 8㎏f

○: 5 kgf or more and less than 6 kgf

X: less than 5 kgf

[Decision criteria of collapsibility]

If the collapse time was less than 60 minutes, it was judged to be acceptable.

◎: Less than 40 minutes

○: 40 minutes or more, less than 60 minutes

×: more than 60 minutes

The components and evaluation of each tablet are shown in Tables 1 and 2.

[Table 1]

[Table 2]

[Footnote in the table]

(Amount of sake yeast body (A) = amount of sake yeast * 0.7) [Dry mass] As the amount of sake yeast body (A) in sake yeast,

Unit of content of each component: mg / tablet

In Tables 1 and 2, the hardness and collapsibility were good in Examples 1 to 6, whereas in Comparative Example 1, which did not include crystalline cellulose, the hardness was low and the collapsibility was not even judged. In Comparative Examples 2 and 3 in which the mass ratio (B / A) of the content (B) of crystalline cellulose to A) was less than 1.3, the hardness was low. These results indicate that the tablet of the present invention is excellent in refinement properties such as hardness and collapsibility.

[Examples 7 to 9]

Tablets were prepared in the same manner as in Example 1 except that the crystalline cellulose described in Table 3 was used as the crystalline cellulose and the pressure was changed to 4 kN. The hardness and the collapse time of each of the obtained tablets were measured in the same manner as in Example 1. The components and evaluation of each tablet are shown in Table 3. &lt; tb &gt; &lt; TABLE &gt; As the crystalline cellulose, Seoras (registered trademark) FD-101, UF-F702, and UF-F711 (both manufactured by Asahi Kasei Corporation) were used as the fine particulate silicon oxide, Capurex FPS- Kasei Chemicals Co., Ltd.) was used.

[Table 3]

[Footnote in the table]

(Amount of sake yeast body (A) = amount of sake yeast * 0.7) [Dry mass]

Unit of content of each component: mg / tablet

It is apparent from Table 3 that in Examples 7 to 9, both hardness and collapsibility were good, and in Example 9 using a crystalline cellulose having a bulk density of less than 0.25, tablet hardness and collapsibility were more excellent.

Claims (5)

(B) of the content of the crystalline cellulose (B) relative to the content of the sake yeast cell body (A) in the tablets containing 15% by mass or more of the sake yeast cell body (A) in the tablet in the tablets containing the sake yeast and the crystalline cellulose / A) is 1.3 or more. The method according to claim 1,
Characterized in that it also contains carboxymethylcellulose calcium (C). 3. The method according to claim 1 or 2,
A tablet characterized by containing at least 23 mass% of sake yeast organism strain (A). 4. The method according to any one of claims 1 to 3,
Wherein the bulk density of the crystalline cellulose (B) is 0.3 g / cm 3 or less. 5. The method according to any one of claims 1 to 4,
Wherein the average particle size of the crystalline cellulose (B) is 100 占 퐉 or less.