KR20170004680A - Iontophoresis device comprising retinol and niacinamide and method for delivering retinol and niacinamide using the same - Google Patents
Iontophoresis device comprising retinol and niacinamide and method for delivering retinol and niacinamide using the same Download PDFInfo
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- KR20170004680A KR20170004680A KR1020150095369A KR20150095369A KR20170004680A KR 20170004680 A KR20170004680 A KR 20170004680A KR 1020150095369 A KR1020150095369 A KR 1020150095369A KR 20150095369 A KR20150095369 A KR 20150095369A KR 20170004680 A KR20170004680 A KR 20170004680A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0444—Membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
Abstract
Description
To an iontophoresis device comprising retinol and niacinamide using reverse electrodialysis and a method for delivering retinol and niacinamide therewith.
Methods for delivering a drug into the body for the purpose of skin cosmetic treatment or treatment include oral administration, topical administration, intravenous administration, intramuscular injection, intracutaneous injection and subcutaneous injection. With the exception of topical administration, where the drug is delivered locally to a particular site of the body, the above-described drug delivery methods generally result in delivery of the drug throughout the body. Such a drug delivery method is not suitable for local delivery of a drug to a specific body tissue.
Therefore, other methods have been developed for drug delivery to specific body tissues such as Natural Orifice Transluminal Endoscopic Surgery (NOTES) and iontophoresis. Iontophoresis is a drug delivery method that allows charged molecules to pass through tissues easily. 1 is a schematic view of a conventional iontophoresis device. Referring to FIG. 1, an iontophoresis device is a technique of penetrating an ion material into a skin using a DC current. In order to utilize a repulsive force acting between ions of the same polarity, ', And the ionic material having a negative characteristic is applied to the' - 'electrode so that the ionic material is easily penetrated into the skin. Unlike traditional transdermal methods where the drug is passively absorbed, iontophoresis devices provide active transport within the electric field.
However, the conventional iontophoresis device has a problem that the oxidation reaction occurs on the surface of the electrode attached to the skin, causing itching, pain, burning, and erythema on the user's skin using the iontophoresis device. Accordingly, it is an object of the present invention to provide an iontophoresis device having an electrode capable of preventing the itching, pain, burning, and erythema that may occur during the process of delivering a drug to the skin, Development of a topressess device is required.
One aspect includes a Reversed Electrodialysis (RED) cell that generates current through a difference in ion concentration between a high-concentration electrolyte solution and a low-concentration electrolyte solution; And a substance containing portion including a substance containing retinol and niacinamide having charge or polarity and connected to one surface of the electrode portion, wherein an electric current generated from the reverse electrodialysis unit flows through the substance containing portion, And to provide an iontophoresis device for delivering a substance containing retinol and niacinamide in a substance-containing portion to a subject.
In another aspect, the present invention provides a method for forming an iontophoresis device, comprising: supplying water to a chamber of the iontophoresis device to form a current between ions in the iontophoresis device; And delivering a substance containing retinol and niacinamide in a substance containing region containing retinol and niacinamide having charge or polarity through the generated electric current to a subject, will be.
One aspect includes a Reversed Electrodialysis (RED) cell that generates current through a difference in ion concentration between a high-concentration electrolyte solution and a low-concentration electrolyte solution; And a substance containing portion including a substance containing retinol and niacinamide having charge or polarity and connected to one surface of the electrode portion, wherein an electric current generated from the reverse electrodialysis unit flows through the substance containing portion, An iontophoresis device for delivering a substance containing retinol and niacinamide in a substance-containing portion to a subject is provided.
Referring to FIG. 2, the reverse
As used herein, the term "retinol" is used interchangeably with "vitamin A" (e.g., vitamin A1), may include a pharmaceutically acceptable salt of retinol, (2E, 4E, 6E, 8E) -3,7-dimethyl-9- (2,6,6-trimethylcyclohex-1-enyl) Can be displayed. In addition, for example, retinol promotes differentiation of cells and promotes biosynthesis of collagen and elastin, thereby suppressing wrinkles and increasing skin elasticity.
Also, the term "niacinamide" is used interchangeably with "nicotinamide or nicotinic amide" and "niancin" and may refer to a component of vitamin B3. The niacinamide may include a pharmaceutically acceptable salt thereof and may be labeled with pyridine-3-carboxyamide according to the IUPAC nomenclature. Also, for example, niacinamide may have a skin whitening effect, an anti-inflammatory effect, and a moisturizing effect. Accordingly, the iontophoresis device comprising retinol and niacinamide according to one embodiment can be applied to the skin to improve the condition of the skin.
The substance containing part may be a hydrogel containing retinol and niacinamide or an aqueous solution containing retinol and niacinamide. For example, the material containing portion may include any material known in the art if it is an ion conductive medium. The substance containing portion may include, for example, an aqueous solution or buffer solution, a hydrogel or a matrix containing or enclosing a substance having charge or polarity. The retinol and niacinamide contained in the substance containing part may be mixed with an enhancer substance having a property of promoting mass transfer. The enhancer can roughly be divided into an enzymatic enhancer and a non-enzymatic enhancer. Enzyme enhancers include proteolytic enzymes such as papain, trypsin, pepsin and bromelain. Non-enzymatic enhancers include lactam compounds, ethyl acetate, ethyl alcohol, dioxolane, nonionic surfactants, , Caprylic acid, capric triglyceride, and n-decyl methyl sulfoxide. These enhancers can be suitably mixed and used depending on the substance to be delivered. Also, the matrix material may include an acrylic or methacrylic resin such as an ester of acrylic acid or methacrylic acid and a polymer of alcohol. The alcohol may include butanol, pentanol, isopentanol, 2-methylbutanol, 3-methylpentanol, 2-ethylbutanol, isooctanol, decanol or dodecanol. In addition, the polymer may contain not only a homopolymer but also an acrylic acid, methacrylic acid, acrylamide, methacrylamide, N-alkoxymethylacrylamide, N-alkoxymethylmethacrylamide, Nt-butyl acrylamide, itaconic acid, N-branched alkylmaleimide glycol diacrylate, or mixtures thereof. ≪ Desc / Clms Page number 5 > Other matrix materials include natural or synthetic rubbers such as styrene butadiene, butyl ether, neoprene, polyisobutylene, polybutadiene and polyisoprene, polyvinyl acetate, urea formaldehyde resins, phenol formaldehyde resins, resorcinol formaldehyde resins Cellulose derivatives such as ethyl cellulose, methyl cellulose, nitrocellulose, cellulose acetate butyrate and carboxymethyl cellulose and natural gums such as guar, acacia, pectin, starch, dextrin, albumin, gelatin, casein and the like. These materials may include adhesives and stabilizers as is well known in the art. Examples of the object to which the substance-containing part is to be delivered in contact with the substance-containing part include humans and other mammals, and specifically, humans, monkeys, mice, rats, rabbits, sheep, Pigs, and the like.
The substance having charge or polarity including the retinol and niacinamide contained in the substance-containing portion may be a substance having charge or polarity by being charged in the ion conductive medium in the substance-containing portion, . The molecular weight (MW) of the material may be, for example, from about 100 to about 2000, from about 200 to about 2000, from about 300 to about 1000, from about 300 to about 800, or from about 400 to about 7000.
In addition, the retinol and niacinamide may be contained in an amount of 0.01 to 50% by weight based on the total weight of the substance in the substance-containing portion.
In one embodiment, the iontophoresis device may be a patch, or patch form, for delivery of retinol and niacinamide through the skin. One side of the substance-containing
As used herein, the term " Reversed Electrodialysis (RED) "may refer to the salinity gradient energy resulting from the difference in salt concentration between the two solutions, and in one embodiment, the iontophoresis device The current flowing through the resistor R may flow. Thus, the reverse electrodialysis cell unit may refer to a device that uses reverse electrodialysis to generate current. For example, in the present specification, the reverse electrodialysis cell unit may generate an electric current by a difference in ion concentration of an electrolyte in a solution between a high-concentration electrolytic solution and a low-concentration electrolytic solution.
In addition, since the iontophoresis device according to one embodiment uses reverse electrodialysis, a separate power source or electrode may not be required, or may have no separate power source or electrode. For example, the battery part may be the only source of current for delivering the material to the object. The iontophoresis device may be a current source for transferring a substance to a target object, and may include only the electrode part, and the battery part may have no separate power source or electrode. The cell portion may use an electrolyte solution to form a current by using the reverse electrodialysis cell portion. As used herein, the term "electrolyte" may mean a material that is dissolved in a solvent such as water to dissociate into ions to flow a current, and the electrolyte solution may mean a solution such as water in which an electrolyte is dissolved. Therefore, the electrolyte may be contained in the electrolyte solution. The reverse electrodialysis cell unit generates a current through a difference between the high concentration electrolyte solution and the low concentration electrolyte solution. The amount of the electrolyte in the chamber containing the high concentration of the electrolyte is higher than the amount of the electrolyte in the chamber containing the low concentration electrolyte. Lt; / RTI > The chamber in which the electrolyte is contained at a low concentration may also include an electrolyte-free chamber. For example, a chamber containing a high concentration of said electrolyte to form a flow of ions may comprise about 0.1 to about 20 mol / L, about 0.5 to about 15 mol / L, about 0.7 to about 10 mol / L, L, about 1.0 to about 2.0 mol / L, or about 1.2 to about 1.8 mol / L, and the chamber containing the electrolyte at a low concentration comprises about 0.1 to about 20 mol / L, about 0.5 to about 15 mol / L, about 0.7 to about 10 mol / L, about 1.0 to about 8.0 mol / L, about 1.0 to about 2.0 mol / L, or about 1.2 to about 1.8 mol / And the ion concentration of the electrolyte solution in the chamber containing the electrolyte at a high concentration may be higher than the ion concentration of the electrolyte solution in the chamber containing the electrolyte at a low concentration. The amount of the electrolyte or the ionic concentration of the electrolyte solution in the chamber containing the high concentration of the electrolyte and the low concentration may be at least about 0.5 volts or more, for example, about 0.5 volt to about 15 volts, May be included at different amounts or concentrations of ions to output a voltage of about 10 volts, about 1.5 volts to about 8.0 volts, about 2.0 volts to about 6.0 volts, about 2.0 volts to about 4.0 volts, or about 2.0 volts to about 3 volts have. About 0.1 mA to about 10 mA, from about 0.2 mA to about 8 mA, from about 0.4 mA to about 6 mA, from about 0.5 mA to about 4 mA, from about 0.5 mA to about 2 mA , Or from about 0.5 mA to about 1 mA. Examples of the electrolyte may include NaCl, MgCl 2, AgCl, CuCl 2, CaCl 2, or in a combination of the two.
As used herein, the term " ion-exchange membrane "may refer to a membrane that is prone to permeate either the cation or the anion. The ion exchange membrane may be a synthetic resin, for example, the synthetic resin may be crosslinked. The cation exchange membrane is negatively charged, so that ions having a negative charge can pass ions having a positive charge without repelling them, and for example, can be a cation exchange membrane having a sulfone group. Conversely, the anion exchange membrane is positively charged, and ions having a positive charge can pass ions having a negative charge without repelling and passing them, and for example, they can be anion exchange membranes having tetravalent ammonium. Examples of the monomer forming the cation exchange membrane include sulfonic acid-type monomers such as 2- (meth) acrylamide-2-methylpropanesulfonic acid, 3- Sulfopropane (meth) acrylate, 10-sulfodecane (meth) acrylate) and salts thereof; For example, 2- (meth) acryloylethylphthalic acid, 2- (meth) acryloylethylsuccinic acid, 2- (meth) acryloylethylsuccinic acid, Acryloylethylmaleic acid, 2- (meth) acryloylethylmaleic acid, 2- (meth) acryloylethyl-2-hydroxyethylphthalic acid ), 11- (meth) acryloyloxydecyl-1,1-dicarboxylic acid, and salts thereof; And a sulfuric acid-type monomer such as 2- (meth) acryloyloxyethyl dihydrogenphosphate, 2- (meth) acryloyloxyethylphenylhydrogenphosphate (2 (meth) acryloyloxyethyl phenyl hydrogenphosphate, 10- (meth) acryloyloxydecyl dihydrogenphosphate, 6- (meth) acryloyloxyhexyl dihydrogenphosphate (6 - (meth) acryloyloxyhexyl dihydrogenphosphate, and salts thereof. Examples of the monomer forming the anion exchange membrane include N, N-dimethylaminoethyl (meth) acrylate, N, N-diethylaminodetyl (meth) N-diethylaminoethyl (meth) acrylate, N, N-dimethylaminoethyl (meth) acrylate / methyl chloride, ) Acrylate / methyl chloride (N, N-diethylaminoethyl (meth) acrylate / methyl chloride). The ion exchange capacity (IEC) of the cation exchange membrane or anion exchange membrane is about 0.5 meg / g or more, or about 1.0 meg / g or more, such as about 0.5 to about 20.0 meg / g, about 1.0 to about 10.0 meg / g, from about 2.0 to about 10.0 meg / g, and from about 5.0 to about 10.0 meg / g. Also, the permeation selectivity of the cation exchange membrane or anion exchange membrane can be about 70% or about 80% or more, such as about 80 to about 100%, about 90 to about 100%, or about 95 to about 100%. In one embodiment, the iontophoresis device may further comprise a spacer for separating the cation and the anion exchange membrane. The spacer may serve to prevent the ion exchange membranes from sticking to each other when the electrolyte solution is housed in the chamber. For example, the spacer may be formed of a polyhedron, a sponge, or a fabric made of polypropylene or polyethelon, .
3, the apparatus includes a second reverse electrodialysis cell 110 'and a second substance containing a substance having charge or polarity and connected to one surface of the second electrode unit 110' Section 120 '. In addition, the second reverse electrodialysis cell unit 110 'includes a cation exchange membrane 111'; An anion exchange membrane 112 'disposed apart from the cation exchange membrane 111'; And a chamber 113 ', 114' disposed between the cation exchange membrane 111 'and the anion exchange membrane 112' and containing an electrolyte, wherein the cation exchange membrane 111 'and the anion exchange membrane 112' And the chambers 113 'and 114' may be alternately arranged in a chamber 113 'containing a high concentration of electrolyte and a chamber 114' containing a low concentration of electrolyte. The
3, the iontophoresis device may further include a
Referring to FIG. 4, a specific example in which the iontophoresis device is activated is shown schematically. In one embodiment, as shown in FIG. 4A, as side walls of the
5, the
Further, in another embodiment, the iontophoresis device may comprise a control for controlling the flow of ions. The control unit may be disposed at a portion connecting the reverse electrodialysis unit and the second reverse electrodialysis unit, or at a portion connecting each of the repeated units. The control unit may include a switch device, a pH sensor, or a salt sensor. For example, the sensor may sense the flow of ions or the output of current in the device to regulate the flow of ions or the output of current through the switch device. The control unit may contain information on the transfer characteristics of the substance (drug) contained in the substance-containing part to the skin. For example, the control unit may include a microprocessor having data on the iontophoresis characteristic for a specific substance (drug) included in the iontophoresis device. The data includes correlations between these conditions and delivery rates when a particular substance (drug) is delivered into the body through the skin by an ionophore system as described above under conditions of flow of a specific current and / or ion . The microprocessor may include a control algorithm according to the transfer characteristics of the substance contained in the substance containing part to the skin. Alternatively, the object or physician may determine the basal administeration level of the substance (drug), i.e., the intensity of the baseline current, according to the data contained in the microprocessor, and administer the substance (drug) . When the necessity of additional administration to the subject occurs during the administration of the substance according to the basic administration rate, for example, when the subject has pain and the substance (drug) administered at the basic rate is an analgesic agent, If the pain is not reduced by the basal administration, additional substance (drug) delivery may be provided. In this case, the condition of the substance (drug) delivery can be determined based on the correlation between the substance (drug) administration condition stored in the microprocessor and the administration rate. The controller may be configured to adjust the intensity of current supplied to the user's skin. The intensity of the current does not necessarily have to be automatically adjusted, but may be such that the intensity of current can be adjusted according to the needs of the patient or the operator. In addition, the controller may be configured to automatically turn on / off the current supplied to the user's skin at predetermined time intervals. The configuration of the electric circuit performing the current control function as described above will be apparent to those skilled in the art and will not be described in further detail herein.
In another embodiment, the iontophoresis device may include a display portion electrically connected to the control portion. The display unit may display an amount of a substance (drug) to be administered under specific conditions, a rate, and a remaining amount of a substance (drug) according to the data included in the control unit. The display portion includes any display device known in the art. For example, it may be an LCD, a PDP, a bank tube, an LED, or the like. In an embodiment of the present invention, a display unit is connected to the control unit, and the display unit displays the amount of the substance (drug) to be delivered, the amount of the substance (drug) The amount of the substance to be delivered (drug), and the amount of the substance to be delivered (drug). The doctor or physician may determine whether to further administer or discontinue the substance (drug) based on the dose of the substance (drug) displayed on the display section, the rate of administration, and the like.
In another aspect, the present invention provides a method for forming an iontophoresis device, comprising: supplying water to a chamber of the iontophoresis device to form an electric current by forming a flow of ions by a cation or an anion exchange membrane between adjacent chambers, Comprising delivering a substance containing retinol and niacinamide in a substance containing section comprising retinol and a substance containing niacinamide to a subject.
In one embodiment, a method of delivering retinol and niacinamide to a subject comprises: generating a flow of ions between adjacent chambers in a chamber containing a high concentration of electrolyte and a low concentration of electrolyte; Generating a current by the flow of ions; And delivering a substance containing retinol and niacinamide in a substance containing section containing a substance containing retinol and niacinamide having charge or polarity by the generated electric current to a subject. The method may further comprise the step of supplying an aqueous solution to the chamber before generating the flow of ions between adjacent chambers to generate a difference in ion concentration of the electrolyte solution in the chamber. Thus, a method according to one embodiment includes generating an electrical current using reverse electrodialysis; And delivering a substance containing retinol and niacinamide in a substance containing section containing a substance containing retinol and niacinamide having charge or polarity by the generated electric current to a subject.
The iontophoresis device and configurations that may be included therein are as described above.
In one embodiment, the method may further comprise the step of contacting the iontophoresis device with the object. The contacting step may be performed before or after the step of generating a difference in the electrolyte ion concentration between the chambers, or the step of generating the current by forming the flow of ions between the adjacent chambers.
The step of generating the current may be generated by the flow of ions formed by the difference in ion concentration of the electrolyte solution in two or more chambers as described above. For example, the reverse electrodialysis as described above may be used Thereby generating an electric current.
The method may be without the step of supplying power to deliver a substance containing retinol and niacinamide to the subject. For example, the method may be such that there is no step of supplying power to deliver the substance to the object, except for the reverse electrodialysis cell part introduced into the iontophoresis device.
According to one aspect, an iontophoresis device and a method of delivering a substance provide improved delivery of retinol and niacinamide containing material through the skin, and an iontophoresis device with electrodes can be used to deliver retinol and niacin It is possible to prevent itching, pain, burning, and erythema that may occur during the process of delivering the amide-containing substance to the skin.
1 is a schematic view of a conventional iontophoresis device.
FIG. 2 is a schematic diagram illustrating a reverse electrodialysis cell and a containing portion of an iontophoresis device according to an embodiment.
FIG. 3 is a schematic diagram illustrating a reverse electrodialysis cell and a containing portion of the iontophoresis device according to one embodiment.
4 is a diagram illustrating the activation principle of the iontophoresis device according to one embodiment.
FIG. 5 is a diagram illustrating a reverse electrodialysis cell and a containing portion of the iontophoresis device according to one embodiment.
Hereinafter, the present invention will be described in more detail with reference to embodiments and drawings. However, these embodiments and drawings are for illustrative purposes only and are not intended to limit the scope of the present invention.
Referring to FIG. 2, the
The reverse
3, the apparatus includes a second reverse electrodialysis cell 110 'and a second substance containing a substance having charge or polarity and connected to one surface of the second electrode unit 110' Section 120 '. In addition, the second reverse electrodialysis cell unit 110 'includes a cation exchange membrane 111'; An anion exchange membrane 112 'disposed apart from the cation exchange membrane 111'; And a chamber 113 ', 114' disposed between the cation exchange membrane 111 'and the anion exchange membrane 112' and containing an electrolyte, wherein the cation exchange membrane 111 'and the anion exchange membrane 112' And the chambers 113 'and 114' may be alternately arranged in a chamber 113 'containing a high concentration of electrolyte and a chamber 114' containing a low concentration of electrolyte. The
3, the iontophoresis device may further include a
Referring to FIG. 4, a specific example in which the iontophoresis device is activated is shown schematically. In one embodiment, as shown in FIG. 4A, as side walls of the
5, the
100: iontophoresis device 110: reverse electrodialysis cell
111: Cation exchange membrane 112: Anion exchange membrane
113, 114: chamber 115: container
120: Adhesive part 130: Water supply part
140: Water permeable membrane
Claims (21)
And a substance containing portion including a substance containing retinol and niacinamide having charge or polarity and connected to one surface of the electrode portion,
And an electric current generated from the reverse electrodialysis cell is allowed to flow through the substance containing portion to transfer a substance containing retinol and niacinamide in the substance containing portion to the object.
Cation exchange membranes;
An anion exchange membrane disposed apart from the cation exchange membrane; And
A chamber defined at least in part for the cation exchange membrane and the anion exchange membrane, the chamber containing an electrolyte,
Wherein the cation exchange membrane and the anion exchange membrane are alternately arranged, and the chamber is alternately arranged in a chamber containing a high concentration of electrolyte and a chamber containing a low concentration of electrolyte.
Wherein the second reverse electrodialysis cell unit comprises:
Cation exchange membranes;
An anion exchange membrane disposed apart from the cation exchange membrane; And
A chamber defined at least in part for the cation exchange membrane and the anion exchange membrane, the chamber containing an electrolyte,
Wherein the cation exchange membrane and the anion exchange membrane are alternately arranged and the chamber is a chamber in which the electrolyte is contained at a high concentration and a chamber in which the electrolyte is contained at a low concentration,
Wherein the reverse electrodialysis cell unit and the second reverse electrodialysis cell unit are connected by a chamber containing a high concentration of salt bridges or electrolytes formed on the uppermost cation or anion exchange membrane of each cell unit, .
And transferring retinol and niacinamide in a substance-containing region containing retinol and niacinamide having charge or polarity through the generated electric current to a subject.
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KR1020150095369A KR20170004680A (en) | 2015-07-03 | 2015-07-03 | Iontophoresis device comprising retinol and niacinamide and method for delivering retinol and niacinamide using the same |
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KR20140137860A (en) | 2013-05-24 | 2014-12-03 | 주식회사 케이헬쓰웨어 | Iontophoresis Drug Delivery Monitoring Device and Method of Iontophoresis Drug Delivery |
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KR20140137860A (en) | 2013-05-24 | 2014-12-03 | 주식회사 케이헬쓰웨어 | Iontophoresis Drug Delivery Monitoring Device and Method of Iontophoresis Drug Delivery |
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